diff --git "a/task49_biolord_summarization.json" "b/task49_biolord_summarization.json" new file mode 100644--- /dev/null +++ "b/task49_biolord_summarization.json" @@ -0,0 +1,36034 @@ +{ + "Contributors": [ + "BioLORD" + ], + "Source": [ + "BioLORD" + ], + "URL": [ + "https://huggingface.co/datasets/FremyCompany/BioLORD-Dataset" + ], + "Categories": [ + "Text Summarization" + ], + "Definition": [ + "Given a long definition, generate the concept of a few words of the definition." + ], + "Reasoning": [], + "Input_language": [ + "English" + ], + "Output_language": [ + "English" + ], + "Instruction_language": [ + "English" + ], + "Domains": [ + "Medical Knowledge" + ], + "Positive Examples": [], + "Negative Examples": [], + "Instances": [ + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of anoikis.", + "output": "regulation of anoikis (Cell Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.", + "output": "PMO AVI-4126 (Pharmacologic Substance)" + }, + { + "input": "Definition: Skeletal described as a metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003", + "output": "malacia; bone (Metabolic Bone Disorder)" + }, + { + "input": "Definition: something described as an order of BIRDS including over 300 species that primarily inhabit coastal waters, beaches, and marshes. They are comprised of shorebirds, gulls, and terns.", + "output": "950-95F ORDER CHARADRIIFORMES (Aves)" + }, + { + "input": "Definition: ethylene glycol described as hypnotic and sedative used in the treatment of insomnia; the safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments; chemical formula CCL3CH(OH)2.", + "output": "Hydrate, Chloral (Halogenated alcohol)" + }, + { + "input": "Definition: something described as past history of artificial enlargement of breast due to choice.", + "output": "History of elective breast augmentation (Finding)" + }, + { + "input": "Definition: something described as agents that promote the production and release of interferons; they include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C; viruses, bacteria, and protozoa have been also known to induce interferons.", + "output": "interferon inducers (Immunologic Factors)" + }, + { + "input": "Definition: something described as a bundle of nerve fibers that originates in the arcuate nuclei, traverses the floor of the fourth ventricle, and terminates in the inferior cerebellar peduncle.", + "output": "Stria medullaris of fourth ventricle (Fourth ventricle structure)" + }, + { + "input": "Definition: something described as situated, occurring, or performed below a fascia.", + "output": "Subfacial (Spatial Concept)" + }, + { + "input": "Definition: regulation of endocrine process described as any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.", + "output": "regulation of adrenotropin secretion (Cell Function)" + }, + { + "input": "Definition: Cell Component described as a macromolecular complex that contains a tube of lipid surrounded by a protein coat.", + "output": "lipid tube (protein-lipid complex)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits.", + "output": "Voltage-Gated Sodium Channel Type 8 (Voltage-Gated Sodium Channels)" + }, + { + "input": "Definition: something described as a fusion gene that results from a chromosomal translocation t(4;19)(q35;q13) which fuses exon 20 of the CIC gene to exon 1 of the DUX4 gene. This fusion is associated with soft tissue sarcoma.", + "output": "t(4;19)/CIC-DUX4 Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Company described as owned by the federal government and receives federal government funding.", + "output": "Federal Non-Military Ownership (Conceptual Entity)" + }, + { + "input": "Definition: Disorder of eye described as invasion and growth of microorganisms in the eye; may be clinically inapparent or result in local cellular injury; occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.", + "output": "eye infections (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Aids or devices that you usually use for any of these activities: Other (for hygiene, reach, grip and activities).", + "output": "HAQ0240 (HAQ-DI Without VAS Questionnaire Question)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid single-dose preparation consisting of a medicated insert to be placed within the tooth socket/periodontal membrane. The biodegradable insert is a sheet which slowly releases active substance(s).", + "output": "Periodontal insert (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as a multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.", + "output": "Gamma-Tubulin Ring Complex (Cell Component)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Toddler Parent Report - In the past one month, how much of a problem has this been for your child: My child wakes up tired.", + "output": "PQL0907 (Intellectual Product)" + }, + { + "input": "Definition: Uterine Corpus Cancer described as uterine corpus carcinoma that is resistant to treatment.", + "output": "Refractory Uterine Corpus Carcinoma (Refractory Female Reproductive System Carcinoma)" + }, + { + "input": "Definition: drug design/synthesis/production described as rare diseases and the drugs and other products related to them, so called because development is not profitable; note that this term has nothing to do with orphan children.", + "output": "orphan disease/drug (Intellectual Product)" + }, + { + "input": "Definition: Disease Clinical Qualifier described as a disease characteristic falling between acute and chronic, but predominantly acute.", + "output": "subacute (Course)" + }, + { + "input": "Definition: Medical Device described as prepackaged collections (either custom or standard) of reusable devices and supplies needed to surgically remove the foreskin of the penis (i.e., perform a circumcision). Items in these kits usually include reusable instruments (e.g., tweezers, probes, hemostats, scissors, scalpels/knives, circumcision clamp, scissors) and supplies such as dressings, skin prep solutions (e.g., disinfectant), anesthetics (e.g., lidocaine), and antibiotics. The kits may be supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Reusable circumcision kits and trays are used in hospitals and in other healthcare facilities.", + "output": "Procedure Kit/Trays, Circumcision, Reusable (Procedure Kit/Trays, Circumcision)" + }, + { + "input": "Definition: CHART-SF Interview Version Questionnaire Question described as craig Handicap Assessment and Reporting Technique-Short Form Interview Version - How many hours per week do you spend in active homemaking including parenting, housekeeping, and food preparation?", + "output": "CHART-SF Interview Version - Hours of Homemaking per Week (Intellectual Product)" + }, + { + "input": "Definition: Software, Physiologic Monitoring described as physiologic monitoring software designed to operate electroencephalography (EEG) monitors, control/monitor a limited number of their functions, and/or process data obtained while monitoring. This software is intended to work only with one or a few models of EEG monitors, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements performed while monitoring the EEG parameters and/or while processing and/or transmitting/receiving patient information from workstations, and/or hospital information systems. EEG monitoring software is not usually available separate from the monitor but may be updated (i.e., through the release of modified versions) during the life of the equipment; the software is mainly used by bedside and telemetric monitors. Dedicated software is available according to the parameters that the equipment can measure (e.g., spectral array, bispectral analysis, level-of-consciousness).", + "output": "Electroencephalography Monitoring Software (Intellectual Product)" + }, + { + "input": "Definition: Virus described as any viral organism that can be assigned to the Influenza A species subtype H5N1.", + "output": "HPAI H5N1 Virus (Influenza A virus subtype H1)" + }, + { + "input": "Definition: cytokine-mediated signaling pathway described as a series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.", + "output": "granulocyte-macrophage colony-stimulating factor receptor signaling pathway (cytokine-mediated signaling pathway)" + }, + { + "input": "Definition: Country described as lands in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand.", + "output": "WF (Country)" + }, + { + "input": "Definition: something described as codanin-1 (1227 aa, ~134 kDa) is encoded by the human CDAN1 gene. This protein may be involved in nuclear membrane integrity.", + "output": "Codanin-1 (Regulatory Protein)" + }, + { + "input": "Definition: Organism Function described as the process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.", + "output": "regulation of systemic arterial blood pressure by endothelin (regulation of systemic arterial blood pressure by hormone)" + }, + { + "input": "Definition: something described as a unit of concentration or mass density equal to one gram of substance per milliliter of solution or one kilogram of substance per liter of solution.", + "output": "kg/L (Mass concentration)" + }, + { + "input": "Definition: Subcellular structure described as an intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins.", + "output": "Mesosome (cellular anatomical entity)" + }, + { + "input": "Definition: something described as increased spaces (diastemata) between most of the teeth in the same dental arch.", + "output": "Multiple diastemata (Tooth structure)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of an external carotid artery.", + "output": "Abnormality of external carotid artery (Anatomical Abnormality)" + }, + { + "input": "Definition: Enzyme described as an enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.", + "output": "immunophilin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Metabolic Problems described as a rare autosomal recessive inherited disorder caused by mutations in the ATP7B gene. It is characterized by copper accumulation in the tissues, particularly brain and liver. It results in liver failure, neurologic, and psychotic manifestations.", + "output": "HEPATONEUROLOGIC WILSON DIS (Congenital and peripartum cerebral disorders)" + }, + { + "input": "Definition: Conceptual Entity described as an indication as to whether the clinical trial has an appointed data monitoring committee.", + "output": "dataMonitoringCommitteeIndicator (Indicator)" + }, + { + "input": "Definition: Drug allergens described as synthetic sex hormone", + "output": "6-alpha-Methyl-17alpha-hydroxyprogesterone Acetate (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays a role in keeping the vessels open via vasodilation and prevention of platelet aggregation. It also plays an important role in regulating the force and rate of contraction. In vivo NO is released by shear stress of ligands that increase intracellular Ca2+ in endothelial cells. The increased intracellular Ca2+ activates nitric oxide synthase III (NOSIII) by promoting the binding of Ca/Calmodulin to the enzyme. NOSIII, which is resident in the Golgi complex, is transported together with caveolin-1 to the caveolae at the plasma membrane via vesicles. Shear stress signals via a potassium channel and the cytoskeleton, which results in tyrosine phosphorylation of specific proteins, activation of phosphatidylinositol 3-kinase, and subsequently in activation of Akt kinase. Akt activation by shear stress, but also by VEGF, activates NOSIII by serine phosphorylation, which increases the affinity of NOSIII for calmodulin. After agonist binding at the plasma membrane, NOSIII-activating receptors translocate to caveolae. VEGF receptor signals via its tyrosine kinase domain. Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate. This calcium flux induces binding of calmodulin to NOSIII, whereas the NOSIII-caveolin-1 interaction is disrupted. At the same time, NOSIII is translocated into the cytosol. On binding of calmodulin, NOSIII generates NO, is enhanced by the interaction with Hsp90. Once activated, NOSIII catabolizes L-arginine to NO, which diffuses out of the cell. NO stimulates guanylate (G-) cyclase and increases cGMP levels. cGMP activates cGMP-dependent protein kinase (PKG), cGMP-inhibited phosphodiesterase (PDEIII), and cGMP-stimulated phosphodiesterase (PDEII). PKG may reduce the force and rate of contraction, possibly by phosphorylating troponin I or by phosphorylating phospholamban. PDEIII is inhibited by the increases in cGMP brought about by NO. This may result in an increase in cAMP and cAMP-dependent protein kinase (PKA). PKA in turn activates Ca2+ channels, countering the effects of PKG. In contrast, cGMP may stimulate PDEII, reduce cAMP levels and PKA activity, and thereby reduce Ca2+ channel activity.", + "output": "Nitric Oxide Pathway (Molecular Function)" + }, + { + "input": "Definition: Antibiotics described as a group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.", + "output": "Antibiotic, Cephalosporin (beta-Lactams)" + }, + { + "input": "Definition: something described as a microscopy staining method that utilizes an orange phthalic indicator dye, which emits green fluorescence in the presence of alkaline solutions.", + "output": "fluorescein stain (Ophthalmological test)" + }, + { + "input": "Definition: Finding described as extraocular tumor clinically evident with proptosis and/or an orbital mass.", + "output": "Retinoblastoma cT4b TNM Finding v8 (Retinoblastoma cT4 TNM Finding v8)" + }, + { + "input": "Definition: Thiazide Diuretics described as a sulphonamide-derivative with thiazide-like diuretic activity. Meticrane acts in a similar manner as the thiazide diuretics.", + "output": "METICRANE (Thiazide Diuretics)" + }, + { + "input": "Definition: something described as a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.", + "output": "axoglial septate junction (Intercellular Junctions)" + }, + { + "input": "Definition: Spatial Concept described as physical location of CDKN2A_Gene", + "output": "9: 21984490-21957752 (Chromosome 9 Physical Location)" + }, + { + "input": "Definition: something described as various NMR methods that can be used to determine 3D structures of macromolecules.", + "output": "Multidimensional NMR Techniques (Magnetic Resonance Imaging)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the methionine in a biological specimen.", + "output": "Methionine Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Malignant tumor of lymphoid hemopoietic and related tissue described as a rare porphyria characterized by a pre-existing myeloid disorder, skin fragility and blistering on the exposed areas, and hemorrhagic bullae typically on the back of the hands. Urine, plasma and fecal porphyrins are increased.", + "output": "Erythropoietic uroporphyria associated with myeloid malignancy (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a quinoline-3-carboxamide linomide analogue with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74080\" active clinical trials using this agent.", + "output": "tasquinimod (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: Pharmacologic Substance described as a long-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to other sulfonylureas, chlorpropamide has an increased risk of prolonged hypoglycemia because of its long half-life. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/775373\" active clinical trials using this agent.", + "output": "Product containing chlorpropamide (Organic Chemical)" + }, + { + "input": "Definition: Mental Process described as directing or governing one's own or another's emotions. Not to be confused with EMOTIONAL MATURITY which involves the exhibition of emotional behavior appropriate to one's age.", + "output": "Emotional Control (Emotional Adjustment)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Encephalopathy, Leukoencephalopathy described as molecular assay reagents intended to identify gene variants associated with megalencephalic leukoencephalopathy with subcortical cysts, a leukodystrophy associated with early-onset megacephaly and delayed-onset neurologic deterioration. Genetic variants at multiple loci have been associated with megalencephalic leukoencephalopathy with subcortical cysts. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple megalencephalic leukoencephalopathy with subcortical cysts-associated loci simultaneously.", + "output": "Vacuolating Megalencephalic Leukoencephalopathy with Subcortical Cysts Gene Panel Reagents (IVD Panels, Human Genetics, Encephalopathy, Leukoencephalopathy)" + }, + { + "input": "Definition: Cell Component described as any HOPS complex that is part of a multivesicular body membrane.", + "output": "multivesicular body membrane HOPS complex location (Cell Component)" + }, + { + "input": "Definition: Congenital Hypothyroidism described as syndrome with characteristics of precocious obesity, congenital hypothyroidism, neonatal colitis, cardiac hypertrophy, craniosynostosis and developmental delay. It has been described in two brothers, one of who died within the first month of life. The parents of the two children were nonconsanguineous and in good health however the pregnancies were complicated by maternal HELLP syndrome (Hemolysis, Elevated Liver enzymes and Low Platelets). The mode of inheritance has not yet been clearly established.", + "output": "Obesity, colitis, hypothyroidism, cardiac hypertrophy, developmental delay syndrome (Congenital anomaly of large intestine)" + }, + { + "input": "Definition: something described as human SLC7A5 wild-type allele is located in the vicinity of 16q24.3 and is approximately 39 kb in length. This allele, which encodes large neutral amino acids transporter small subunit 1 protein, is involved in cellular uptake of large neutral amino acids.", + "output": "MPE16 (Gene or Genome)" + }, + { + "input": "Definition: something described as catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+.", + "output": "versiconal reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: something described as appendiceal carcinoma with tumor invading muscularis propria.", + "output": "Appendiceal Carcinoma pT2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of eosinophil chemotaxis.", + "output": "regulation of eosinophil chemotaxis (Cell Function)" + }, + { + "input": "Definition: something described as lymphoma that occurs in a pig.", + "output": "Porcine Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as performance of the Upper Limb Module for DMD Version 2.0 - Push on light.", + "output": "PUL0218 (PUL 2.0 Functional Test Question)" + }, + { + "input": "Definition: negative regulation of cytokine production described as any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production.", + "output": "downregulation of interleukin-25 production (Organism Function)" + }, + { + "input": "Definition: Vulva, labia, clitoris and Bartholin's gland described as the external genital organs of the female", + "output": "VULVA: GENERAL TERMS (Structure of female anogenital region)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Hearing Loss, Nonsyndromic described as molecular assay reagents intended to identify deletions and duplications in genes associated with nonsyndromic hearing loss/deafness, a collection of genetic hearing loss/deafness diseases that are not associated with signs and symptoms affecting other parts of the body. Genetic variants at multiple loci have been associated with nonsyndromic hearing loss/deafness. These reagents are intended to detect deletions and duplications in multiple nonsyndromic hearing loss/deafness-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Hearing Loss, Nonsyndromic, Del/Dup (IVD Panels, Human Genetics, Hearing Loss, Nonsyndromic)" + }, + { + "input": "Definition: Aneurysm described as abnormal outpouching or sac-like dilatation in an artery that originates from he abdominal aorta.", + "output": "Dilatation of an abdominal artery (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as bacteria culture media that are available either as liquid or semisolids in ready-to-use tubes. Some of these media may need supplementation with other reagents before use.", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Tube (IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media)" + }, + { + "input": "Definition: Sternum part described as the smallest and most inferior triangular protrusion of the STERNUM or breastbone that extends into the center of the RIBCAGE.", + "output": "sternum xiphoid process (Zone of sternum)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.", + "output": "neuroendocrine cell differentiation (neuroepithelial cell differentiation)" + }, + { + "input": "Definition: HealthcareProviderTaxonomyHIPAA - CodeSystem described as nurses who are specially trained to assume an expanded role in providing medical care under the supervision of a physician.", + "output": "Physician Assistants & Advanced Practice Nursing Providers; Nurse Practitioner (Nurses)" + }, + { + "input": "Definition: chromosome localization described as any process in which a telomere is transported to, and/or maintained in, a specific location.", + "output": "telomere localisation (chromosome localization)" + }, + { + "input": "Definition: Health Care Related Organization described as a funding project supporting research towards measuring the quality of cancer care in the United States. It is to be a five-year project (starting which will support prospective cohort studies on 10,000 patients with newly diagnosed lung or colorectal cancers. The project is designed to increase the knowledge of the relationship between cancer care practices in the general population and patient outcomes including survival and quality of life.", + "output": "Cancer Care Outcomes Research and Surveillance Consortium (Cancer Surveillance Project)" + }, + { + "input": "Definition: something described as the coexistence of two or more disease processes.", + "output": "comorbidities (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Physical Regulation Component described as change in or modification of somatic control", + "output": "Physical Regulation Alteration (Finding)" + }, + { + "input": "Definition: Medical Device described as clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluid (typically blood) samples to determine the level of glucose-6-phosphate dehydrogenase activity. Glucose-6-phosphate dehydrogenase deficiency may dispose patients to developing hemolytic anemia when exposed to certain drugs (e.g., primaquine, thiazide diuretics), foods (e.g., fava beans), or stress.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Enzyme, Glucose-6-PhosphateDehydrogenase (Medical Device)" + }, + { + "input": "Definition: something described as a dimpled condition of the skin of the breast, resembling the skin of an orange, sometimes found in inflammatory breast cancer.", + "output": "breast appearance peau d'orange (Appearance of breast)" + }, + { + "input": "Definition: Multiple malformation syndrome with facial-limb defects as major feature described as an extremely rare multiple congenital abnormality syndrome that has characteristics of microcephaly, malar hypoplasia with downslanting palpebral fissures, highly arched palate, apparently low-set and protruding ears, micrognathia, short stature, bilateral hearing loss, and learning disability. Occasionally, additional features have been observed such as bilateral cryptorchidism, cardiac valvular lesions, body asymmetry, and pectus excavatum.", + "output": "Branchial Arch Syndrome, X-Linked (Multiple malformation syndrome with facial-limb defects as major feature)" + }, + { + "input": "Definition: Perinatal anemia described as anemia, the cause of which is present at birth.", + "output": "Congenital anaemia NOS (Congenital hematological disorder)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Functional Assessment of Cancer Therapy-Taxane Version 4 (FACT-Taxane Version 4) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "CDISC Questionnaire FACT-Taxane Version 4 Test Name Terminology (Intellectual Product)" + }, + { + "input": "Definition: Limb structure described as multiple exostoses originating in long bones.", + "output": "Multiple long-bone exostoses (Finding)" + }, + { + "input": "Definition: Syringes, Plunger, Protective described as hypodermic syringes designed to provide needlestick protection (safety). These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, to lessen the possibility of contact of the healthcare provider with a sharp needle.", + "output": "Syringes, Plunger, Hypodermic, Protective (Hypodermic Syringes)" + }, + { + "input": "Definition: regulation of glial cell-derived neurotrophic factor secretion described as any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor secretion.", + "output": "negative regulation of glial cell line-derived neurotrophic factor secretion (negative regulation of cytokine secretion)" + }, + { + "input": "Definition: Metallopeptidase Gene described as this gene is involved in the catabolism of insulin and other bioactive peptides.", + "output": "IDE Gene (Metallopeptidase Gene)" + }, + { + "input": "Definition: Spiritual nursing care described as assisting in processing the discharge of a patient from a facility consistent with his or her religious beliefs. Service is billed in 15-minute increments.", + "output": "sprtlnrse DC fsilt asistnce (Health Care Activity)" + }, + { + "input": "Definition: Syndrome described as progressive ascending motor neuron paralysis of unknown etiology, frequently following an enteric or respiratory infection.", + "output": "Landry's paralysis (Immune-mediated neuropathy)" + }, + { + "input": "Definition: Intellectual Product described as pain Intensity (PI v1) Least pain intensity for various time periods of evaluation.", + "output": "PI01-Least Pain Intensity (PI Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin.", + "output": "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: inborn lipid/lipoprotein disorder described as an autosomal recessive syndrome caused by mutations in the DHCR7 gene, encoding 7-dehydrocholesterol reductase, the enzyme responsible for the first step of cholesterol synthesis. The enzyme deficiency results in reduced production of steroid hormones and underdevelopment of male genitalia due to androgen deficiency. This condition may also be associated with microcephaly, developmental delay, characteristic facial anomalies, and syndactyly.", + "output": "smith-lemli-opitz syndrome (disorder of bile acid and cholesterol metabolism)" + }, + { + "input": "Definition: protein domain specific binding described as interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT.", + "output": "Rel homology domain binding (Molecular Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 1 (FGF-1. Because of the mitogenic and angiogenetic effects of FGF-1 on fibroblasts and endothelial cells, therapeutic FGF-1 has a potential role in wound healing; because FGF-1 has been shown to induce neurogenesis, therapeutic FGF-1 may have a role in nerve regeneration.", + "output": "Recombinant Fibroblast Growth Factor 1 (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as the estimated average blood pressure.", + "output": "Mean Blood Pressure, Estimated (Blood pressure finding)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a cortical area defined on the basis of internal structure and located in the hilus of the dentate gyrus in the human ( Duvernoy-2005 ) and the macaque ( Rosene-1987 ). It is not clearly distinguishable in the rat and is often designated as part of the polymorphic layer of the dentate gyrus ( Amaral-1978 ).\\r\\nCA4 borders the CA3 field where the pyramidal cell layer of the CA fields enters the hilus of the dentate gyrus and spreads out to occupy most of the hilus ( de No-1934 ). The polymorphic layer of the dentate gyrus is clearly distinct from CA4 and serves as its border with the dentate gyrus ( Rosene-1987 ). The internal structure of CA4 is not uniform, the neuronal cell bodies are ovoid, large, few in number and scattered among intertwined myelinated fibers.", + "output": "sub-field CA4 (Segment of hippocampus proper)" + }, + { + "input": "Definition: Curved 5th toe phalanx described as a deviation from the normal straight form of the distal phalanx of the fifth toe.", + "output": "Curved outermost bone of the pinkie toe (Abnormality of the distal phalanx of the 5th toe)" + }, + { + "input": "Definition: Cyclooxygenase Inhibitors described as prototypical analgesic used in the treatment of mild to moderate pain; has antiinflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins; aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.", + "output": "Acetylsalicylic acid (Platelet aggregation inhibitors excl. heparin)" + }, + { + "input": "Definition: Patient Reported Outcome Measures described as patient-reported measure of outcome in sino-nasal disorders such as rhinosinusitis and nasal polyposis.", + "output": "Sino-Nasal Outcome Test (Patient Reported Outcome Measures)" + }, + { + "input": "Definition: something described as catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.", + "output": "ubiquitin-like modifier activating enzyme activity (ligase activity, forming carbon-sulfur bonds)" + }, + { + "input": "Definition: General anatomical term described as a thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures.", + "output": "Membrane (Body tissue)" + }, + { + "input": "Definition: Structure of ligament of distal tibiofibular joint described as skeletal ligament, each instance of which is a fibrous band that passes diagonally, inferiorly, and laterally from the posterior part of the distal end of some tibia to the adjacent posterior part of the distal end of some fibula.", + "output": "Posterior tibiofibular ligament (Skeletal ligament)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transcriptional initiation.", + "output": "TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD (Gene or Genome)" + }, + { + "input": "Definition: Bacterium described as a species of facultatively anaerobic, Gram-positive, Gram-negative or Gram-variable, rod shaped bacteria assigned to the phylum Firmicutes. This species is motile, catalase positive, indole negative, reduces nitrate, hydrolyzes casein and gelatin, but not starch or urea and forms spores with a distinct canoe shaped body that is attached to the side of the spore in a lateral position within the sporangium. B laterosporus is found in soil, water, insects and their larvae, and may be pathogenic in humans.", + "output": "Bacillus latersporus (Genus Bacillus)" + }, + { + "input": "Definition: Cytochromes described as cytochromes (electron-transporting proteins) with protoheme (HEME B) as the prosthetic group.", + "output": "b Cytochromes, Heme (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the paired immunoglobulin fragments composed of the variable domains of the heavy and light chains.", + "output": "Immunoglobulin Fv Fragments (Immunologic Factor)" + }, + { + "input": "Definition: Mammal described as twenty-two species of new world monkeys in the genera Callithrix, Cebuella, Callibella, and Mico.", + "output": "Marmoset (Cebidae)" + }, + { + "input": "Definition: Functional Concept described as administration within the gingivae.", + "output": "Intragingival (Parenteral Route of Drug Administration)" + }, + { + "input": "Definition: modulation of programmed cell death in other organism involved in symbiotic interaction described as any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction.", + "output": "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction (positive regulation of killing of cells of other organism)" + }, + { + "input": "Definition: something described as a hip joint femoral (hemi-hip) metallic resurfacing prosthesis is a device intended to be implanted to replace a portion of the hip joint. This generic type of device includes prostheses that have a femoral resurfacing component made of alloys, such as cobalt-chromium-molybdenum.", + "output": "Prostheses, Hip, Femoral, Resurfacing (Medical Device)" + }, + { + "input": "Definition: something described as human ANG wild-type allele is located within 14q11.1-q11.2 and is approximately 10 kb in length. This allele, which encodes angiogenin protein, plays a role in the inhibition of protein synthesis via hydrolysis of cellular tRNAs.", + "output": "RNASE4 (Gene or Genome)" + }, + { + "input": "Definition: Malvaceae described as a plant genus of the family BOMBACACEAE. The fine silky hairs covering the seeds have been used for floatation, stuffing, and insulation.", + "output": "Ceiba Mill. (Bombacoideae)" + }, + { + "input": "Definition: Transport Pathway described as phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsinization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.", + "output": "Fc Gamma Receptor-Mediated Phagocytosis Pathway (Immune Response Regulation Pathway)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic hydroxamate with potential antineoplastic activity. Batimastat binds covalently to the zinc ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.", + "output": "(4-(N-hydroxyamino)-2-isobutyl-3-(thiophen-2-ylthiomethyl)succinyl)phenylalanine-N-methylamide (Matrix Metalloproteinase Inhibitors)" + }, + { + "input": "Definition: something described as a portion of the nucleus of ansa lenticularis located medial to the posterior limb of the internal capsule, along the course of the ansa lenticularis and the inferior thalamic peduncle or as a separate nucleus within the internal capsule adjacent to the medial GLOBUS PALLIDUS (NeuroNames, http://rprcsgi.rprc. washington.edu/neuronames/ (September 28, 1998)). In non-primates, the entopeduncular nucleus is analogous to both the medial globus pallidus and the entopeduncular nucleus of human.", + "output": "Entopeduncularis, Nucleus (Nucleus of brain)" + }, + { + "input": "Definition: Meperidine analog-containing product described as the hydrochloride salt of a synthetic piperidine ester with opioid analgesic activity. Meperidine mimics the actions of endogenous neuropeptides via opioid receptors such as the mu-opiiod receptor, thereby producing characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C635\" active clinical trials using this agent.", + "output": "Pethidine hydrochlor [anaesth] (Opioid Receptor Agonist)" + }, + { + "input": "Definition: Laboratory or Test Result described as a measurement of the blue-staining characteristic of newly generated erythrocytes.", + "output": "Polychromatophilic stain reaction (Hematology)" + }, + { + "input": "Definition: organelle membrane fusion described as the joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.", + "output": "endoplasmic reticulum membrane fusion (Cell Function)" + }, + { + "input": "Definition: something described as a state of uncertainty regarding the therapeutic advantages of one treatment over another.", + "output": "Clinical Equipoise (Functional Concept)" + }, + { + "input": "Definition: Biologically Active Substance described as a nanoparticle-based prodrug formulation consisting of polymeric micelles incorporating the inorganic platinum agent cisplatin with potential antineoplastic activity. In micellar nanoparticle-encapsulated cisplatin NC-6004, cisplatin forms a polymer-metal complex with hydrophilic polyethylene glycol poly(glutamic acid) block copolymers by attaching to the micelle inner core consisting of the hydrophobic polymer polyamino acid. Upon cell entry and release from the polymer-metal complex, cisplatin forms highly reactive, charged platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-linking, DNA-protein cross-linking and, subsequently, tumor cell apoptosis and growth inhibition. Due to the hydrophilic nature of polyethylene glycol, this formulation increases the water-solubility of cisplatin and decreases the nephrotoxicity and neurotoxicity associated with the administration of cisplatin alone. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85476\" active clinical trials using this agent.", + "output": "micellar nanoparticle-encapsulated cisplatin NC-6004 (Biologically Active Substance)" + }, + { + "input": "Definition: Software, Workstation Management described as software designed to operate radiotherapy record and verify workstations, control/monitor a limited number of their functions, and/or process data obtained during the radiotherapy procedure. The software may interrupt the radiotherapy procedure if the parameters (e.g., radiation intensity, target area) are outside pre-established values. This software usually interacts with devices used in the procedure, such as the radiotherapy unit (e.g., linear accelerator, cobalt unit), recorders, and monitors; it may also run a variety of algorithms to facilitate the analysis of the measurements performed during the radiotherapy procedure. Radiotherapy record and verify workstation management software is intended to work only with one or a few models of workstations and related devices, usually supplied by the same manufacturer, facilitating also the processing and/or sending data from the workstation to and from hospital information systems. The software is not usually available separate from the workstation but may be updated (i.e., through the release of modified versions) during the life of the equipment.", + "output": "Radiotherapy Record/Verify Workstation Management Software (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of cardiac ventricle development.", + "output": "regulation of cardiac ventricle development (Organ or Tissue Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare syndrome caused by the deletion of the distal band on the short arm of chromosome 1. It is characterized by a distinctive facial appearance (microcephaly, deep set eyes, flat nose, and pointed chin), developmental abnormalities, mental retardation, seizures, hypotonia, hearing loss, and heart defects.", + "output": "1p Telomere Deletion Syndrome (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: something described as a private institution charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive. This process, called Conformity Assessment, has EU-wide validity once completed by the NB.", + "output": "NB (Population Group)" + }, + { + "input": "Definition: Staphylococcus aureus described as a subgroup of S. aureus bacteria that lack the enzymatic function of beta-lactamase and are therefore sensitive to beta-lactam (penicillin) antibiotics.", + "output": "Beta-Lactamase Negative Staphylococcus Aureus (Bacterium)" + }, + { + "input": "Definition: something described as the sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.", + "output": "visual cascade (Vision)" + }, + { + "input": "Definition: Medical procedure on respiratory tract described as actions performed to support breathing treatments", + "output": "breath treatment (Care plan)" + }, + { + "input": "Definition: something described as virus diseases caused by CALICIVIRIDAE. They include HEPATITIS E; VESICULAR EXANTHEMA OF SWINE; acute respiratory infections in felines, rabbit hemorrhagic disease, and some cases of gastroenteritis in humans.", + "output": "Infection, Caliciviridae (Disease or Syndrome)" + }, + { + "input": "Definition: something described as clinical chemistry reagents intended for semiquantitative determination of ketones in in a sample of whole blood in a short period of time, typically several minutes (i.e., rapid tests). Increased blood concentration of ketones (ketonemia) is associated with diabetes mellitus, alcohol comsumption, frequent vomiting, and/or starvation. Semi-quantitative determination of ketones in blood is more accurate than their determination in urine.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Whole Blood, Ketone (Medical Device)" + }, + { + "input": "Definition: Lumbosacral plexus neuropathy described as disease involving the femoral nerve. The femoral nerve may be injured by ISCHEMIA (e.g., in association with DIABETIC NEUROPATHIES), nerve compression, trauma, COLLAGEN DISEASES, and other disease processes. Clinical features include MUSCLE WEAKNESS or PARALYSIS of hip flexion and knee extension, ATROPHY of the QUADRICEPS MUSCLE, reduced or absent patellar reflex, and impaired sensation over the anterior and medial thigh.", + "output": "Lesion of femoral nerve, unspecified lower limb (Lumbosacral plexus neuropathy)" + }, + { + "input": "Definition: Molecular Function described as any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.", + "output": "negative regulation of cGMP-mediated signaling (regulation of cGMP-mediated signaling)" + }, + { + "input": "Definition: Congenital heart valve disorder described as a congenital disorder of the aortic valve in which the orifice of the valve fails to develop.", + "output": "aortic atresia (Aortic valve disorder)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.", + "output": "nucleoside diphosphate anabolism (nucleoside diphosphate metabolic process)" + }, + { + "input": "Definition: SKIN, NAILS, HAIR described as the process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.", + "output": "aged skin (Skin Physiological Phenomena)" + }, + { + "input": "Definition: Metaplasia described as conversion of a mature, normal cell or groups of mature cells to other forms of mature cells.", + "output": "Metaplasia, NOS (Metaplasia)" + }, + { + "input": "Definition: Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma described as ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma).", + "output": "Precursor T-Lymphoblastic Lymphoma/Leukemia Stage I (Neoplastic Process)" + }, + { + "input": "Definition: something described as a superficial feature of the frontal lobe. It is a short horizontal groove found in 30% of human brains. Parallel to the longitudinal fissure, it is located within the superior frontal gyrus just anterior to the central sulcus and dorsal to the superior precentral sulcus ( Ono-1990 ). Equivalent features are not found in the macaque or in the smooth cerebral cortex of the rat or mouse ( NeuroNames ).", + "output": "marginal precentral sulcus (Body Space or Junction)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally available inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family, is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression and in tumor cell growth and survival.", + "output": "INCB059872 (Pharmacologic Substance)" + }, + { + "input": "Definition: Organizational Innovation described as processes, tools, and techniques involved in the management of ORGANIZATIONAL INNOVATION, the purpose of which is to help individuals and work groups make successful personal transitions which ensure overall successful outcomes.", + "output": "Change Managements, Organizational (Occupational Activity)" + }, + { + "input": "Definition: Uterine Corpus Sarcoma described as a term that refers to the staging of uterine corpus sarcoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas of the uterine corpus. It does not apply to carcinosarcomas which are staged according to the carcinomas and carcinosarcomas of the uterine corpus.", + "output": "Uterine Corpus Sarcoma by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.", + "output": "catalytic activity, acting on a glycoprotein (Molecular Function)" + }, + { + "input": "Definition: Wisterieae described as a plant genus of the family FABACEAE. Members contain wistarin, wisteria lectin and wistariasaponin.", + "output": "Wisterias (Plant)" + }, + { + "input": "Definition: something described as an abnormality of the functioning of the vestibular apparatus.", + "output": "Impaired vestibular function (Central Nervous System)" + }, + { + "input": "Definition: Genome Components described as a functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function.", + "output": "Genes (PDQ)" + }, + { + "input": "Definition: Elopement Propensity Risk described as meandering, aimless, or repetitive locomotion that exposes the individual to harm; frequently incongruent with boundaries, limits, or obstacles.", + "output": "Aimless walking (Disorientated in place)" + }, + { + "input": "Definition: Action described as the act of gathering an item.", + "output": "COLLECTING (Functional Concept)" + }, + { + "input": "Definition: something described as any elsewhere undefined thermography, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "Undefined thermography (thermography)" + }, + { + "input": "Definition: Histone antibody Assay described as the determination of the amount of histone 4 antibody present in a sample.", + "output": "Histone 4 Antibody Measurement (Histone antibody Assay)" + }, + { + "input": "Definition: Bone marrow or hematopoietic stem cell transplant described as the transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.", + "output": "Grafting of bone marrow NOS (Transplantation and Donation)" + }, + { + "input": "Definition: Organic Chemical described as a class of thiocarbamate derivatives whose salts possess fungicidal activity.", + "output": "Ethylenebis(dithiocarbamates) (Thiocarbamates)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid.", + "output": "(+)-beta-barbatene synthase activity (carbon-oxygen lyase activity, acting on phosphates)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Clinical Chemistry, Buffer described as clinical chemistry reagents used as buffers in assays performed to determine the electrolyte (e.g., sodium, potassium, chloride) content in body fluids, usually keeping the pH of the solution as constant as possible.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Buffer, Electrolyte Test (IVD Test Reagent/Kits, Clinical Chemistry, Buffer)" + }, + { + "input": "Definition: DNA-Cytosine Methylases described as enzymes that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the 5-position of CYTOSINE residues in DNA.", + "output": "Deoxyribonucleic acid (cytosine-5)-methyltransferase (Enzyme)" + }, + { + "input": "Definition: Oligonucleotides described as an antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of phosphates. Morpholinos are used to inhibit translation or splicing of specific, complementary mRNAs.", + "output": "Morpholino Oligomer, Phosphorodiamidate (Oligonucleotides)" + }, + { + "input": "Definition: Comamonadaceae described as a genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.", + "output": "DELFTIA (Comamonadaceae)" + }, + { + "input": "Definition: Finding described as an abnormality of divalent inorganic cation homeostasis.", + "output": "Abnormal blood inorganic cation concentration (Finding)" + }, + { + "input": "Definition: positive regulation of TOR signaling described as any process that activates or increases the frequency, rate or extent of TORC2 signaling.", + "output": "up-regulation of TORC2 signal transduction (Molecular Function)" + }, + { + "input": "Definition: Refractory Aggressive Non-Hodgkin Lymphoma described as angioimmunoblastic T-cell lymphoma resistant to treatment.", + "output": "Angioimmunoblastic T-Cell Lymphoma Refractory (Angioimmunoblastic Lymphadenopathy)" + }, + { + "input": "Definition: Laboratory Procedure described as a technique used to measure the rate of physiological activity plotted against wavelength of light. An action spectrum depicts the most effective wavelength of light (also known as spectral sensitivity) that is required for each specific process.", + "output": "Spectrum, Action (Laboratory Procedure)" + }, + { + "input": "Definition: Nail plate described as the cutaneous plate on the dorsal surface of the distal end of a finger or toe.", + "output": "nail structure (epidermal derivative)" + }, + { + "input": "Definition: Abnormality of the antitragus described as absence of the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.", + "output": "Absent antitragus (Abnormality of the antitragus)" + }, + { + "input": "Definition: something described as any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.", + "output": "negative regulation of gene silencing (negative regulation of cellular process)" + }, + { + "input": "Definition: Conceptual Entity described as an object representing a structure that is capable of measuring the absolute or relative amount of a given compound.", + "output": "Expression Measurement (UML Entity)" + }, + { + "input": "Definition: Report described as documentation that contains routine trial status progress.", + "output": "Trial Stas Rept (Report)" + }, + { + "input": "Definition: something described as a regimen consisting of abiraterone acetate that may be used in the treatment of metastatic prostate cancer.", + "output": "Abiraterone Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as g protein coupled surface receptor that mediates acetylcholine action on smooth and cardiac muscle and in CNS; may be linked to a potassium channel (membrane polarization) or second messenger systems.", + "output": "Muscarinic Receptor (Synaptic Receptors)" + }, + { + "input": "Definition: T-cell/histiocyte rich large B-cell lymphoma described as t-cell/histiocyte-rich large B-cell lymphoma that is resistant to treatment.", + "output": "Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (T-cell/histiocyte rich large B-cell lymphoma)" + }, + { + "input": "Definition: Adrenal Cortical Adenoma described as a rare adenoma of the adrenal cortex that produces estrogens. Male patients may develop gynecomastia and impotence.", + "output": "Estrogen-Producing Adrenal Cortex Adenoma (Adrenal Cortical Adenoma)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila Species described as molecular assay reagents intended to identify Chlamydophila pneumoniae, a bacterium of the family Chlamydiaceae, by detecting specific genetic information of the ribosomal ribonucleic acid (rRNA) of the target bacteria. These bacteria may cause respiratory infections and mild atypical pneumonia.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila pneumoniae, RRNA (Medical Device)" + }, + { + "input": "Definition: something described as the benzathine salt form of a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis.", + "output": "Cloxacillin benzathine (Organic Chemical)" + }, + { + "input": "Definition: Plant described as perennial herb Symphytum officinale, in the family Boraginaceae, used topically for wound healing. It contains ALLANTOIN, carotene, essential oils (OILS, VOLATILE); GLYCOSIDES; mucilage, resin, SAPONINS; TANNINS; triterpenoids, VITAMIN B12, and ZINC. Comfrey also contains PYRROLIZIDINE ALKALOIDS and is hepatotoxic if ingested.", + "output": "Comfrey (Boraginaceae)" + }, + { + "input": "Definition: Cardiac Glycoside [EPC] described as cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin; digoxin has positive inotropic and negative chronotropic activity; used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation; its use in congestive heart failure and sinus rhythm is less certain; the margin between toxic and therapeutic doses is small.", + "output": "Product containing digoxin (Digitalis Glycosides)" + }, + { + "input": "Definition: Abnormality of the elbow described as an anomaly of the joint between the trochlear notch of ulna and the trochlea of humerus, which is part of the elbow joint.", + "output": "Abnormality of the humeroulnar joint (Abnormality of the elbow)" + }, + { + "input": "Definition: something described as an electrocardiographic finding of a normal QRS complex followed by a premature ventricular complex for 3 or more consecutive cycles; a regularly irregular rhythm of normal and abnormal QRS complexes in a 1-1 ratio.", + "output": "Ventricular Bigeminy (Ventricular Arrhythmia by ECG Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as family of transcription factors involved in cytokine-induced activation of gene expression by binding to the enhancer; essential for HIV expression.", + "output": "Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (Protein or Riboprotein Complex)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar.", + "output": "purine nucleoside bisphosphate metabolism (nucleoside bisphosphate metabolic process)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate.", + "output": "obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity (carbon-oxygen lyase activity)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Level 2b Failure to Thrive is defined by either of two criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a spring balance scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following three requirements must be present: a) Weight is measured using an electronic scale or beam balance scale; b) Length is documented using infantometer; c) Weight for length ratio less than or equal to the third centile on an appropriate growth chart.", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 2b Failure to Thrive (Intellectual Product)" + }, + { + "input": "Definition: Pelvis Cancer Pathologic Primary Tumor TNM Finding v8 described as pelvis cancer with tumor confined to one pelvic segment with extraosseous extension or two segments without extraosseous extension.", + "output": "Pelvis Cancer pT2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as the determination of the ratio of macrophages compared to leukocytes in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "MCPHGLE (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Fallopian Tube Anastomotic Leak, CTCAE described as severe symptoms; invasive intervention indicated", + "output": "Grade 3 Fallopian tube anastomotic leak (Finding)" + }, + { + "input": "Definition: Teeth and Tooth Structures described as the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected.", + "output": "dentin (dental structure)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.", + "output": "hypoxanthine metabolic process (purine nucleobase metabolic process)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as terminology relevant to the classification of the genetic region under study.", + "output": "CDISC SDTM Genetic Region of Interest Type Terminology (Intellectual Product)" + }, + { + "input": "Definition: Finding described as distal bile duct cancer with metastasis in one to three regional lymph nodes.", + "output": "Distal Bile Duct Cancer pN1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.", + "output": "tau protein binding (Molecular Function)" + }, + { + "input": "Definition: FDA Stability Data Standards Terminology described as terminology developed to support Pause Descriptions within the Stability Data Standards.", + "output": "Stability Study Pause Description Terminology (Intellectual Product)" + }, + { + "input": "Definition: regulation of RNA binding transcription factor activity described as any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity.", + "output": "positive regulation of RNA binding transcription factor activity (regulation of RNA binding transcription factor activity)" + }, + { + "input": "Definition: something described as multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54) In general, would you say your health is:", + "output": "MSQL1-Would You Say Your Health Is (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as enclosed pass-throughs designed to pass samples from the patient area into the clinical laboratory. These cabinets consist of a wall-mounted, stainless-steel, or, less frequently, plastic structure; they may include either doors on opposite sides or a revolving plate by which the samples are moved into the laboratory.", + "output": "Clinical Laboratory Pass-Through Cabinets (Pass-Throughs, Enclosed)" + }, + { + "input": "Definition: Medical Device Operates Differently Than Expected described as problem with visual messages which continue to be displayed on/by the device after the appropriate action has been taken.", + "output": "Visual Prompts will not Clear (Medical Device Operates Differently Than Expected)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate.", + "output": "phosphotagatokinase activity (Molecular Function)" + }, + { + "input": "Definition: Manufactured Object described as a device designed to detect light.", + "output": "Photodetector (Manufactured Object)" + }, + { + "input": "Definition: Antibiotics, ophthalmologic described as a broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.", + "output": "Amikacinum (Antibiotics, Aminoglycoside)" + }, + { + "input": "Definition: something described as a measurement of Norovirus genogroup II.4 IgM antibody present in a sample.", + "output": "Norovirus GII.4 IgM antibody (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as a population of plasma cells which display atypical morphological features, an abnormal immunophenotypic profile, and molecular genetic characteristics of clonality (monoclonality).", + "output": "Aberrant Clonal Plasma Cells (Finding)" + }, + { + "input": "Definition: amino-acid betaine metabolic process described as the chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.", + "output": "betaine breakdown (cellular nitrogen compound catabolic process)" + }, + { + "input": "Definition: something described as a mitosporic fungal genus. P. brasiliensis (previously Blastomyces brasiliensis) is the etiologic agent of PARACOCCIDIOIDOMYCOSIS.", + "output": "Genus Paracoccidioides (Form family Moniliaceae)" + }, + { + "input": "Definition: something described as components of the biliary tract that are referenced in topographic category C24 of ICD-O-3.", + "output": "Other and Unspecified Parts of Biliary Tract (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as life Events Checklist for DSM-5, Standard Version - Any other very stressful event or experience: Learned about it.", + "output": "LEC-5 Standard Version - Other Stressful Event: Learned (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.", + "output": "cytokinin metabolism (Molecular Function)" + }, + { + "input": "Definition: spore wall biogenesis described as a cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall.", + "output": "ascospore wall biogenesis (Cell Function)" + }, + { + "input": "Definition: something described as short-Form McGill Pain Questionnaire-2 (Short Form MPQ) Throbbing pain.", + "output": "SFMP201 (Short-Form MPQ-2 Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the anatomic location that is the focus of the observation.", + "output": "Performed Observation Target Anatomic Site Code (Target Anatomic Site Code)" + }, + { + "input": "Definition: B [Preparations] described as an orally bioavailable recombinant human immunoglobulin G1 monoclonal antibody directed against human fibroblast growth factor 23 (FGF23), that can be used to increase serum phosphate levels. Upon subcutaneous administration, burosumab binds to and inhibits FGF23, thereby interfering with FGF23 signaling. This increases tubular phosphate reabsorption, decreases excretion of phosphate, and increases serum phosphate levels, resulting in enhanced bone mineralization. FGF23, a member of the fibroblast growth factor (FGF) family produced by osteocytes, plays a key role in hypophosphatemic rickets/osteomalacia, such as X-linked hypophosphatemia (XLH) and tumor-induced rickets/osteomalacia. Increased FGF23 levels lead to decreased expression of the sodium-phosphate co-transporters in the proximal tubules, reduced renal phosphate reabsorption, increased excretion by the kidneys, and low serum phosphate concentration.", + "output": "BUROSUMAB (B [Preparations])" + }, + { + "input": "Definition: something described as systems that combine radiographic and fluoroscopic capabilities. These systems produce instantaneous (i.e., real-time) visual images (fluoroscopies), permanent x-ray film images (radiographs), and/or digital images for later detailed study and for archiving.", + "output": "Radiographic/Fluoroscopic Table Systems (Medical Device)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the gap junction protein beta 2 (GJB2) gene, located at chromosome 13q11-q12, which encodes the gap junction beta-2 protein. Genetic variants at this locus have been associated with deafness, hystrix-like ichthyosis with deafness, keratitis-ichthyosis-deafness syndrome, keratoderma palmoplantar deafness, Bart-Pumphrey syndrome, and mutilating keratoderma.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, GJB2 (Medical Device)" + }, + { + "input": "Definition: Finding described as the presence of macroscopically visible residual tumor at the edge of a surgically excised specimen.", + "output": "Macroscopically Positive Surgical Margin (Finding)" + }, + { + "input": "Definition: Left side of trunk described as the testis on the left side of the body.", + "output": "Testis.left (Testis)" + }, + { + "input": "Definition: something described as ambiguous genitalia, lax skin, hyperextensible joints, hernias, craniosynostosis, retarded psychomotor development, and osseous and facial abnormalities.", + "output": "SCARF (skeletal abnormalities, cutis laxa, craniostenosis, psychomotor retardation, facial abnormalities) syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: vasoactive intestinal polypeptide receptor binding described as interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor.", + "output": "type 2 PACAP receptor binding (vasoactive intestinal polypeptide receptor binding)" + }, + { + "input": "Definition: something described as treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.", + "output": "Third-Line Therapy (Procedure by intent)" + }, + { + "input": "Definition: Health Care Activity described as addition or change in provision of plant sterol esters (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)", + "output": "Management of plant sterol ester intake (Health Care Activity)" + }, + { + "input": "Definition: Central Nervous System described as a herniation of meninges through a congenital bone defect in the skull in the occipital region.", + "output": "Meningocele, occipital (Congenital Disorders)" + }, + { + "input": "Definition: Intestinal disorders congenital described as a congenital malformation characterized by the absence of a normal opening in a part of the ileum.", + "output": "Atresia of ileum (Atresia of small intestine)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as this syndrome is characterised by epilepsy, learning difficulties, macrocephaly, and aggressive behaviour. It has been described in males from a four-generation kindred. It is transmitted as an X-linked recessive trait and is likely to be caused by mutations in the gene encoding synapsin I (Xp11.3-q12).", + "output": "X-linked epilepsy with learning disability and behavior disorder syndrome (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Transcription Factors, General described as factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.", + "output": "Pol1 Transcription Initiation Complex Proteins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: With configuration described as a serial arrangement in which things follow in logical order or a recurrent pattern.", + "output": "Sequence (Functional Concept)" + }, + { + "input": "Definition: something described as a subscale of the Pediatric Quality of Life Brain Tumor Module designed to assess issues associated with pain and hurting.", + "output": "Pain and Hurt (Pediatric Quality of Life Brain Tumor Module Version 1.0)" + }, + { + "input": "Definition: something described as anatomical conduit between two adjacent vertebrae.", + "output": "Foramenina intervertebralia (Anatomical conduit)" + }, + { + "input": "Definition: Body Location or Region described as the most caudoventral of three parts of the dysgranular insula in the human. The others are insular dysgranular area 2 and insular dysgranular area 3 ( Zilles-2012 ).", + "output": "insular dysgranular area 1 (Body Location or Region)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as the combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system.", + "output": "Technique, Optogenetic (Molecular Biology Research Technique)" + }, + { + "input": "Definition: something described as the time at which the patient was transferred into the recovery area.", + "output": "Time of patient arrival in post anaesthesia care location (Timing milestone)" + }, + { + "input": "Definition: something described as the process in which the structure of a heart valve is generated and organized.", + "output": "heart valve morphogenesis (Morphogenesis)" + }, + { + "input": "Definition: Clinical Attribute described as a circumferential measurement of the largest part of the forearm.", + "output": "FARMCIR (Clinical Attribute)" + }, + { + "input": "Definition: Cell Function described as the migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.", + "output": "hindbrain tangential cell migration (Cell Function)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Control described as reagents consisting of substances of known concentrations that are assayed by the usual clinical laboratory methods and that resemble the unknown specimen; they are used for quality control of serologic tests performed for the determination of antigens and/or antibodies in human specimens due to infection by pathogenic bacteria that cause infectious diseases.", + "output": "IVD Test Reagent/Kits, Serology, Control, Bacteria (Medical Device)" + }, + { + "input": "Definition: something described as the process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.", + "output": "olfactory bulb axon guidance (Cell Function)" + }, + { + "input": "Definition: Non-human infectious disorder described as a transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.", + "output": "Marek disease (Hematologic neoplasm of uncertain behavior)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the monocytoid cells to leukocytes in a biological specimen.", + "output": "MOCYCELE (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Biologically Active Substance described as f-box/LRR-repeat protein 18 (805 aa, ~88 kDa) is encoded by the human FBXL18 gene. This protein is involved in the modulation of protein ubiquitination.", + "output": "F-Box/LRR-Repeat Protein 18, human (Ubiquitination Regulation Protein)" + }, + { + "input": "Definition: something described as a state in the northern midwest United States. Its capital is Bismarck.", + "output": "north dakota (Midwestern United States)" + }, + { + "input": "Definition: Professional Organization or Group described as an alliance of 19 leading US cancer centers, an authoritative source of information to help patients and health professionals make informed decisions about cancer care. Through the collective expertise of its member institutions, the NCCN develops, updates, and disseminates a complete library of clinical practice guidelines. These guidelines are the standard for clinical policy in oncology.", + "output": "National Comprehensive Cancer Network (Health Care Related Organization)" + }, + { + "input": "Definition: ObservationMethod - CodeSystem described as an analytical technique wherein gas chromatography is coupled to mass spectrometry in order to separate, identify, and quantify substances in a sample.", + "output": "SPECTROMETRY MASS GAS CHROMATOGR (Mass Spectrometry)" + }, + { + "input": "Definition: Cell Component described as the component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.", + "output": "anchored component of presynaptic active zone membrane (Cell Component)" + }, + { + "input": "Definition: Physicians; Physician/Osteopath described as a surgeon with expertise in the management of surgical conditions in premature and newborn infants, children and adolescents.", + "output": "pediatric surgeons (Physicians; Physician/Osteopath)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Testicular hemorrhage (Finding)" + }, + { + "input": "Definition: Finding described as the length of time since the birth of the imaging subject in completed units. [Adapted from: Google and caDSR Public ID 2423393] EXAMPLE(S): 17 years (years completed) OTHER NAME(S): NOTE(S): This value is derived from the path: Subject > PerformedObservation > PerformedObservationResult.value (ANY=>PQ.TIME) WHERE PerformedObservation > DefinedObservation.nameCode = \"age\"", + "output": "PerformedImagingStudy.subjectAge (Subject Age)" + }, + { + "input": "Definition: Neoplasms, Glandular and Epithelial described as type of cancer", + "output": "Other Carcinoma (Neoplasms, Glandular and Epithelial)" + }, + { + "input": "Definition: Other diseases due to viruses and Chlamydiae described as a contagious infection that is caused by the mumps virus; it is characterized by swollen and tender parotid glands.", + "output": "MUMPS (Viral infection of the digestive tract)" + }, + { + "input": "Definition: FACT-COG Version 3 Questionnaire Question described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 (FACT-COG Version 3) Perceived Cognitive Impairments: I have had trouble remembering where I put things, like my keys or my wallet.", + "output": "FAC07505 (Intellectual Product)" + }, + { + "input": "Definition: Balance, device described as general purpose laboratory equipment labeled or promoted for a specific medical use is a device that is intended to prepare or examine specimens from the human body and that is labeled or promoted for a specific medical use.", + "output": "Analytical Balances (Balance, device)" + }, + { + "input": "Definition: Health Care Activity described as the process by which information about the health status of an individual is obtained after a study has officially closed; an activity that continues something that has already begun or that repeats something that has already been done.", + "output": "CLSFUP (Health Care Activity)" + }, + { + "input": "Definition: Cell Component described as a spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.", + "output": "U12-type precatalytic spliceosome (Cell Component)" + }, + { + "input": "Definition: something described as characterized by the presence of multiple extrahepatic and intrahepatic cysts.", + "output": "Choledochal Cyst, Type IV (Congenital Abnormality)" + }, + { + "input": "Definition: Steroids described as a glucuronosyltransferase-modified, alcohol-conjugated metabolite of the steroid androsterone and metabolite of the steroid dihydrotestosterone produced in visceral adipose tissue, with weak androgenic activity. Androstane-3,17-diol glucuronide may be used as a marker for peripheral androgen activity.", + "output": "5-alpha-androstane-3 alpha,17 beta-diol glucuronide (Organic Chemical)" + }, + { + "input": "Definition: Telangiectasis described as presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions.", + "output": "Telangiectasia of the skin (Telangiectasis)" + }, + { + "input": "Definition: Reticular formation of pons described as the part of the medial reticulospinal tract in the pons ( NeuroNames ).", + "output": "Reticulospinal tract of pons (extrapyramidal tract)" + }, + { + "input": "Definition: something described as the determination of the ratio of immunoglobulin G to creatinine in a biological specimen.", + "output": "Immunoglobulin G to Creatinine Ratio Measurement (Urine protein test)" + }, + { + "input": "Definition: something described as 60S ribosomal protein L22 (128 aa, ~15 kDa) is encoded by the human RPL22 gene. This protein is involved in the mediation of translation.", + "output": "Heparin-Binding Protein HBp15 (Biologically Active Substance)" + }, + { + "input": "Definition: cullin-RING ubiquitin ligase complex described as a ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).", + "output": "SCF ubiquitin ligase complex location (Cell Component)" + }, + { + "input": "Definition: Cancer Vaccines described as a peptide cancer vaccine comprised of a peptide derived from Wilms tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, WT1 peptide vaccine OCV-501 may stimulate a CD4-positive helper T-lymphocyte-mediated immune response against WT1 expressing cells. WT1 protein, a zinc finger DNA-binding protein, is overexpressed in leukemic cells and in some solid tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C106257\" active clinical trials using this agent.", + "output": "WT1 peptide vaccine OCV-501 (Pharmacologic Substance)" + }, + { + "input": "Definition: Leukemia recurrent described as the reemergence of chronic leukemia after a period of remission.", + "output": "Recurrent Chronic Leukemia (Neoplastic Process)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius.", + "output": "cellular response to freezing (Cell Function)" + }, + { + "input": "Definition: something described as emotion Recognition Test (ERT) Total number of stimuli (face images) for which the participant's response was incorrect.", + "output": "EMO103B (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a character or string that represents a tumor results group.", + "output": "Tumor Results Group Identifier (Group ID)" + }, + { + "input": "Definition: Congenital anomaly of finger described as a very rare congenital cranial dysinnervation disorder with characteristics of complete or incomplete facial paralysis in association with bilateral palsy of the abducens nerve causing impairment of ocular abduction. The syndrome also includes various other congenital anomalies.", + "output": "M\u00f6bius Syndrome (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: something described as a chronic, relapsing, pustular eruption that is localized to the palms and soles.", + "output": "Pustulosis of palms and soles (Dermatitis)" + }, + { + "input": "Definition: Platelet precursor described as the precursor of a megakaryocyte.", + "output": "Basophilic megakaryoblast (Thrombocytopoietic cell)" + }, + { + "input": "Definition: Rheumatic illness with extraarticular and/or constitutional features (fever, rash, pleurisy,etc) OR Systemic illness with rheumatic manifestation described as having to do with the lungs.", + "output": "Pulmono- (Respiratory site descriptor)" + }, + { + "input": "Definition: something described as a characterization of the tumor tissue site based on whether disease has spread (e.g., primary or metastatic site).", + "output": "Tumor Tissue Origin (Conceptual Entity)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Additional Concerns: I have diarrhea (diarrhoea).", + "output": "FAC015-I Have Diarrhea (FACT-HEP Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Aeromonas described as a species of gram-negative bacteria, in the family Aeromonadaceae. It is strictly parasitic and often pathogenic causing FURUNCULOSIS in SALMONIDS and ulcer disease in GOLDFISH.", + "output": "Bacterium salmonicida (Bacterium)" + }, + { + "input": "Definition: something described as any individual related biologically or legally to another individual and considered immediate family as in the case of a spouse, parent, sibling or child.", + "output": "First Degree Relative (Family Group)" + }, + { + "input": "Definition: something described as a rare X-linked intellectual disability syndrome characterised by onset in infancy of delayed motor and speech milestones, generalised tonic-clonic seizures and drop attacks and mild to moderate intellectual disability. Additional less common manifestations include scoliosis, ataxia (resulting in progressive gait disturbance) and bilateral pes planovalgus. Physical appearance is normal with no dysmorphic features reported.", + "output": "X-linked intellectual disability Hedera type (Mental Retardation)" + }, + { + "input": "Definition: Therapeutic procedure described as application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease.", + "output": "Gene therapy (Medical therapy)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Mycobacterium tuberculosis IgA antibodies in a biological specimen.", + "output": "Mycobacterium tuberculosis IgA Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: Fusion Proteins, bcr-abl described as a fusion protein encoded by the BCR/ABL1 fusion gene with ABL1 NM_005157.4:c.758A>T mutation. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein where the tyrosine at position 253 of the ABL1 protein has been replaced by phenylalanine.", + "output": "BCR/ABL Tyr253Phe Mutation (Fusion Proteins, bcr-abl)" + }, + { + "input": "Definition: 5-HT>3< receptor antagonist described as an extended-release (ER), polymer-based injectable formulation containing the indazole derivative granisetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor type 3 (5-HT3) antagonist, with anti-emetic activity. Upon subcutaneous administration, granisetron is released from the polymer in a sustained manner, which is based upon the controlled hydrolysis of the polymers, and selectively binds to and inhibits the activity of the 5-HT3 receptors located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema. By preventing stimulation of 5-HT3 receptors, granisetron is able to suppress chemotherapy-induced nausea and vomiting (CINV). Compared to the injection of granisetron alone, injection of the polymer-based formulation allows for therapeutic levels of granisetron over an extended period of time.", + "output": "Granisetron Extended-release Injection (5-HT>3< receptor antagonist)" + }, + { + "input": "Definition: something described as an ion channel with selective permeability for sodium.", + "output": "ION CHANNEL NA (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a phenylalanine derivative of the meglitinide class of agents with hypoglycemic activity. Nateglinide, compared to repaglitinide, binds with a higher affinity to the SUR1 subunit and with a faster onset of action and a shorter duration of action. This agent is metabolized by the cytochrome P450 isoenzyme CYP2C9, and, to a lesser extent, by CYP3A4. The parent drug and metabolites are mainly excreted in the urine and its half-life is about 1.5 hours.", + "output": "Product containing nateglinide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.", + "output": "C3-C5 Convertase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as penile prostheses in the form of one or more rods implanted in the penis to provide penile tumescence and permit sexual contact. These prostheses typically consist of rigid or semirigid polymeric or silicone elastomer rods; some include metallic reinforcements. Rod penile prostheses are intended for patients who suffer from erectile dysfunction.", + "output": "Penile Prostheses, Rod (Medical Device)" + }, + { + "input": "Definition: regulation of establishment of planar polarity involved in neural tube closure described as the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.", + "output": "planar cell polarity pathway involved in neural tube closure (Wnt signaling pathway, planar cell polarity pathway)" + }, + { + "input": "Definition: Organic Chemical described as term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.", + "output": "Hexouronic Acids (Uronic Acids)" + }, + { + "input": "Definition: Receptor described as cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.", + "output": "Biogenic Amines Receptors (Receptors, Cell Surface)" + }, + { + "input": "Definition: Dosage Form and Package Type described as medicinal product consisting of prolonged-release granules for oral suspension presented in a sachet.", + "output": "Prolonged-Release Granules for Oral Suspension in Sachet (Dosage Form and Package Type)" + }, + { + "input": "Definition: Professional Organization or Group described as a group or agency that gives legal help to people with low incomes. Health legal aid workers help people with issues related to getting good healthcare, and getting insurance to cover certain patients and conditions.", + "output": "Legal Aid Organization (Professional or Occupational Group)" + }, + { + "input": "Definition: Neoplastic Process described as an aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by significant cytologic atypia, increased mitotic activity, and necrosis. The prognosis is usually poor.", + "output": "Undifferentiated Ovarian Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Biologic Function described as the process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.", + "output": "female genital development (Biologic Function)" + }, + { + "input": "Definition: Stage III Colon Cancer AJCC v7 described as stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. M0: No distant metastasis.", + "output": "Stage IIIA Colon Cancer AJCC v7 (Neoplastic Process)" + }, + { + "input": "Definition: Reticular activating system described as the midbrain portion of the reticular formation located in the MIDBRAIN TEGMENTUM.", + "output": "Midbrain Reticular Formations (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Gene or Genome described as human PSMC2 wild-type allele is located within 7q22.1-q22.3 and is approximately 25 kb in length. This allele, which encodes 26S protease regulatory subunit 7 protein, plays a role in both ATP hydrolysis and the modulation of proteasomal activity.", + "output": "Mammalian Suppressor of sgv-1 of Yeast Gene (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 2 on an anxiety scale that ranges from 0: No Anxiety to 10: Worst Possible Anxiety.", + "output": "Anxiety Score 2 (Intellectual Product)" + }, + { + "input": "Definition: drug paraphernalia described as a device for smoking herbal substances that filters and cools the smoke by passing it through water.", + "output": "pipe water (drug paraphernalia)" + }, + { + "input": "Definition: Finding described as a morphologic finding indicating the transformation of non-smooth muscle cells to smooth muscle cells.", + "output": "Smooth Muscle Metaplasia (Mesenchymal Metaplasia)" + }, + { + "input": "Definition: Orthotic Devices described as orthoses designed for external modification of the structural and/or functional characteristics of the anterior thoracic muscular and bone structures, providing immobilization and support or supplementing and/or augmenting the chest functions and/or structure. These orthoses typically consist of flexible or semi-rigid structures with elastic fabric bands and have appropriate physical characteristics (e.g., shape, consistency) to encircle the chest totally or at a particular area. Thoracic orthoses are typically made of fabrics, plastics, malleable metals or a combination of these. Dedicated prefabricated or, less frequently, custom-made orthoses intended for a particular region of the anterior chest (e.g., sternum, ribs) are available.", + "output": "ORTHOSIS, THORACIC (Orthotic Devices)" + }, + { + "input": "Definition: something described as personal actions to administer oral and topical medications to meet therapeutic goals independently with or without assistive device", + "output": "Self-care: non-parenteral medication (Self Care outcome)" + }, + { + "input": "Definition: something described as a semi-quantitative microscopic finding indicating that 5 percent or less of the nucleated cells in a bone marrow sample are immature mononuclear cells.", + "output": "Blasts Less than or Equal to 5 Percent of Bone Marrow Nucleated Cells (Laboratory or Test Result)" + }, + { + "input": "Definition: Branch of middle cerebral artery described as arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.", + "output": "arteris temporal (Branch of sphenoid part of middle cerebral artery)" + }, + { + "input": "Definition: Small Intestinal Perforation, CTCAE 5.0 described as life-threatening consequences; urgent operative intervention indicated", + "output": "Grade 4 Small intestinal perforation (Small Intestinal Perforation, CTCAE 5.0)" + }, + { + "input": "Definition: something described as catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.", + "output": "17beta-HSD (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Organic Chemical described as salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.", + "output": "Tetradecanoates (Organic Chemical)" + }, + { + "input": "Definition: Helicobacter described as any bacterial organism that can be assigned to the species Helicobacter rappini.", + "output": "Helicobacter rappini (Helicobacter)" + }, + { + "input": "Definition: something described as social effort most active in the 19th and early 20th centuries dedicated to promoting moderation or complete abstinence in the use of ALCOHOLIC BEVERAGES.", + "output": "anti-alcohol movement (Human Activities)" + }, + { + "input": "Definition: Patchy sclerosis of finger phalanx described as uneven increase in bone density of one or more of the phalanges of the 5th finger.", + "output": "Uneven increase in bone density in pinkie finger bone (Anatomical Abnormality)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.", + "output": "deoxyribodipyrimidine photo-lyase activity (DNA photolyase activity)" + }, + { + "input": "Definition: R Wave Abnormality by ECG Finding described as the occurrence of a premature ventricular complex near the peak of the T wave in electrocardiography; it may lead to ventricular tachycardia or fibrillation.", + "output": "R on T phenomenon (Finding)" + }, + { + "input": "Definition: Finding described as problem associated with the complete inability to provide suction.", + "output": "Suction Failure Associated with Medical Device (Suction Issue Associated with Medical Device)" + }, + { + "input": "Definition: Syringes, Plunger, Prefilled, Catheter Flush described as prefilled syringes supplied with a specific catheter-flush solution (e.g., saline, heparin) and that end in a blunt cannula. These syringes are intended to avoid the use of needles, thus providing needlestick prevention, as well as to minimize errors and contamination by supplying premeasured unit doses of the solutions.", + "output": "Syringes, Plunger, Prefilled, Catheter Flush, Blunt Cannula (Syringes, Plunger, Protective)" + }, + { + "input": "Definition: Intellectual Product described as negative Symptom Assessment-16 - Reduced social drive.", + "output": "NSA01-Reduced Social Drive (NSA-16 Clinical Classification Question)" + }, + { + "input": "Definition: Abnormal branching pattern of the aortic arch described as a congenital anomaly in which the aorta is displaced to the right and passes behind the esophagus, thus forming a vascular ring that may cause compression of the trachea and esophagus.", + "output": "Right-sided aortic arch (Disorder of aortic arch and descending aorta)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult - In the past one month, how much of a problem has this been for you: It is hard for me to ask the doctors and nurses questions.", + "output": "PQL01-Hard Ask Doctors/Nurses Questions (Intellectual Product)" + }, + { + "input": "Definition: Gastrointestinal Disorders - Other, Specify, CTCAE described as moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL", + "output": "Grade 2 Gastrointestinal disorders - Other, specify (Finding)" + }, + { + "input": "Definition: something described as human NYNRIN wild-type allele is located in the vicinity of 14q12 and is approximately 21 kb in length. This allele, which encodes protein NYNRIN, may play a role in DNA integration.", + "output": "FLJ11811 (Gene or Genome)" + }, + { + "input": "Definition: Expiration, function described as distinct from cell or tissue respiration, Respiration is the act of breathing with the lungs and consists of inspiration, or taking ambient air into the lungs, and expiration, or expelling modified air that contains more carbon dioxide than the air taken in.", + "output": "Breathing (RESPIRATORY FUNCTIONS: GENERAL TERMS)" + }, + { + "input": "Definition: Verrucous carcinoma described as a highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border.", + "output": "Vulvar Verrucous Carcinoma (Verrucous carcinoma)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose.", + "output": "cellotetraose binding (oligosaccharide binding)" + }, + { + "input": "Definition: something described as the approximate intake of total fat in grams per day derived from parenteral nutrition infusion.", + "output": "Estimated parenteral intake of fat and oil in 24 hours (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as other important events that occur during a trial but are not driven by protocol requirements.", + "output": "Non-Protocol Disposition Event (Intellectual Product)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the inferoseptal portion of the mid-cavity division of the left ventricular myocardium as determined using the AHA 17-Segment Model (Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002 Jan 29;105(4):539-42.).", + "output": "Left Ventricular Mid Inferoseptal Segment (Heart part)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of vasculature development.", + "output": "regulation of vasculature development (regulation of multicellular organismal development)" + }, + { + "input": "Definition: Behavioral Responses: Patient and Family - Knowledge/Psychosocial described as lack of information, understanding, or comprehension", + "output": "Knowledge deficit (Cognition)" + }, + { + "input": "Definition: Pharmacologic Substance described as an injectable radiopharmaceutical formulation containing human serum albumin (HSA) microspheres labeled with technetium-99m (Tc-99m) with diagnostic imaging activity. Technetium Tc 99m-labeled albumin microspheres contain the gamma-emitting Tc99m, a metastable nuclide of molybdenum-99. Upon injection into the hepatic artery, the radionuclide portion allows for SPECT (single photon emission computed tomography) imaging of distribution patterns of the albumin microspheres. This may possibly predict the distribution of other agents with similar particle sizes within the liver and may give a prediction of the tumor response upon administration of such agents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C92580\" active clinical trials using this agent.", + "output": "(99m)Tc-labeled albumin microspheres (Radioconjugate)" + }, + { + "input": "Definition: Intellectual Product described as diabetes Distress Scale for Partners of Adults with Type 1 Diabetes (PARTNER-DDS) Diabetes and me: Moderate distress or greater? (mean score > 2).", + "output": "DDS03-Diabetes and Me: Moderate (PARTNER-DDS Questionnaire Question)" + }, + { + "input": "Definition: something described as a circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide.", + "output": "hexameric IgM antibody (Cell Component)" + }, + { + "input": "Definition: pigment granule organization described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.", + "output": "eye pigment granule organization and biogenesis (Cell Function)" + }, + { + "input": "Definition: something described as scarlet monkeyflower.", + "output": "mimulus cardinalis/scarlet m (Flower Essences)" + }, + { + "input": "Definition: hematopoietic or lymphoid organ development described as a process of blood formation and more specifically formation of blood cells that are all derived from hematopoietic stem cells.", + "output": "hematogenesis (HEMATOPOIETIC SYSTEM: GENERAL TERMS)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of glutamine transport.", + "output": "positive regulation of glutamine transport (positive regulation of amino acid transport)" + }, + { + "input": "Definition: Metabolic disorders NEC described as reduced or absent secretion of mineralocorticoids, primarily aldosterone.", + "output": "Adrenocortical insufficiency NOS (Hormone abnormality)" + }, + { + "input": "Definition: Psychology described as conceptually broad term referring to the affective aspects of human consciousness. Use a more specific term if possible. Use ANIMAL EMOTIONALITY for nonhuman subjects.", + "output": "Emotion, NOS (Mental Processes)" + }, + { + "input": "Definition: Antiparkinson Agents described as an orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, preladenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.", + "output": "7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)- (Organic Chemical)" + }, + { + "input": "Definition: Morphogenesis described as the process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).", + "output": "forebrain morphogenesis (Morphogenesis)" + }, + { + "input": "Definition: Layer of dermis described as the lower portion of the dermis beneath the papillary dermis. It is composed of thick collagen fibers.", + "output": "reticular layer (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Disease or Syndrome described as excessive, increased hair growth located in the region of the forehead and temple. []", + "output": "Frontotemporal hypertrichosis (Disease or Syndrome)" + }, + { + "input": "Definition: Quantitative Concept described as a dosing unit equal to the amount of active ingredient(s) contained in an intravenous bag.", + "output": "Intravenous Bag Dosing Unit (Bag Dosing Unit)" + }, + { + "input": "Definition: Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v7 described as major salivary gland cancer with no metastasis to regional lymph nodes.", + "output": "Major Salivary Gland Cancer pN0 TNM Finding v6 and v7 (Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v6)" + }, + { + "input": "Definition: Research Activity described as RESEARCH activity focused on PHARMACY.", + "output": "Research, Pharmacy (Research Activity)" + }, + { + "input": "Definition: Dietary Supplements described as an eicosapentaenoic acid derivative with potential antineoplastic activities. Upon oral administration, eicosapentaenoic acid monoacylglyceride (MAG-EPA) may inhibit epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR) and serine/threonine protein kinase AKT (protein kinase B)-mediated signaling pathways and reduce vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF1-alpha) expression levels in tumor cells. This may promote apoptosis and inhibit tumor cell growth in cells expressing EGFR, AKT, and VEGFR. MAG-EPA may also inhibit androgen-stimulated tumor cell growth and repress androgenic induction of prostate-specific antigen (PSA) expression. PSA, a tumor associated antigen (TAA), is expressed by prostate epithelial cells and is overexpressed in prostate cancer. The AKT signaling pathway is often dysregulated in cancer and is associated with tumor cell proliferation, survival and migration. EGFR and VGFR are receptor tyrosine kinases that are mutated or upregulated in many tumor cell types and play a key role in tumor cell proliferation and tumor vascularization.", + "output": "Monoglyceride Eicosapentaenoic Acid (Dietary Supplements)" + }, + { + "input": "Definition: Finding described as vulvar cancer with three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi.", + "output": "Vulvar Carcinoma pN2a TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as an electrocardiographic finding in which there are variations in the shape, amplitude, or direction of the T wave from one beat to the next.", + "output": "T wave alternans (Electrical alternation of heart)" + }, + { + "input": "Definition: HL7PublishingDomain described as a part of a thing, or of several things, taken to demonstrate or to determine the character of the whole, e.g. a substance, or portion of material obtained for use in testing, examination, or study; particularly, a preparation of tissue or bodily fluid taken for examination or diagnosis.", + "output": "^Specimen (Materials)" + }, + { + "input": "Definition: protein kinase regulator activity described as modulation of the activity of the enzyme phosphorylase kinase.", + "output": "phosphorylase kinase regulator activity (Molecular Function)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated; intubation", + "output": "Grade 4 Guillain-Barre Syndrome, CTCAE (Finding)" + }, + { + "input": "Definition: Abnormal salivary gland morphology described as any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands.", + "output": "Abnormality of the sublingual glands (Abnormal salivary gland morphology)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult Parent Report - In the past one month, how much of a problem has this been for your child: I think money is a problem in our family.", + "output": "PQL02-Money Problem in Our Family (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences loosely conserved in eukaryotes. Telomerase is a ribonucleoprotein complex which in vitro recognizes a single-stranded G-rich telomere primer and adds multiple telomeric repeats to its 3-prime end by using an RNA template. Telomerase may also have a role in de novo formation of telomeres. Telomerase has been identified in many cultured cell lines and actively dividing cell types. The active reverse transcriptase component has been identified as the TERT protein. The presence of this factor determines the availability of the telomerase function. The TERT protein has a high turnover rate and its expression is regulated by factors that promote growth (c-MYC, v-k-ras, Bcl-2, and E6) and inhibiting factors (RB and p53) that promote cell death or that block cell division. It appears that the regulation of active telomerase has many levels and can be inhibited by TEP1 not releasing TERT or by TRF1 which binds the end repeats and prevents access to the chromosome ends. Additional modulation is due to phosphorylation by PKC and AKT or dephosphorylation by PP2A. Human telomeres consist of many kilobases of (TTAGGG)n together with various associated proteins. Small amounts of these terminal sequences are lost from the tips of the chromosomes during each S phase because of incomplete DNA replication, but de novo addition of TTAGGG repeats by the enzyme telomerase compensates for this loss. Many human cells progressively lose terminal bases with each cell division, a loss that correlates with the apparent absence of telomerase in these cells. There has been considerable interest in the possible relationship between human telomeres and cellular senescence and immortalization. This interest includes the question of a role in the malignant process and the question of the use of telomerase inhibitors as anti-tumor drugs.", + "output": "Telomere Pathway (Genetic Information Processing Pathway)" + }, + { + "input": "Definition: Major Salivary Gland Cancer Pathologic Primary Tumor TNM Finding v8 described as major salivary gland cancer with no evidence of a primary tumor.", + "output": "Major Salivary Gland Cancer pT0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Antipseudomonal penicillin described as a semisynthetic, narrow-spectrum, beta-lactamase-resistant penicillin with antibacterial activity. Temocillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.", + "output": "temocillina (T [Preparations])" + }, + { + "input": "Definition: something described as a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.", + "output": "Dolasetron Mesylate (dolasetron)" + }, + { + "input": "Definition: something described as storage cabinets designed to accommodate one or more bedpans and/or urinals. These cabinets are typically made from metal (e.g., stainless steel, aluminum) to avoid corrosion and permit ease of cleaning and sterilization, usually providing enough internal open space to allow air circulation. Bedpan/urinal cabinets are typically mounted on the wall and are either recessed or surface mounted. Each bedpan or urinal is usually stored in an individual compartment inside the cabinet.", + "output": "Urinal Storage Cabinets (Cabinets, Storage)" + }, + { + "input": "Definition: IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question described as international Physical Activity Questionnaire (November 2002) - Long Last 7 Days Telephone Format - How much time did you usually spend on one of those days walking as part of your work?: Hours per day.", + "output": "IPAQ Long Last 7 Days Telephone Format Version - Walking Work Hours per Day (Intellectual Product)" + }, + { + "input": "Definition: Embryonic Structure described as any one of six primary lymph sacs located at the root of the intestinal mesentery on the posterior abdominal wall in the developing fetus.", + "output": "Retroperitoneal Lymph Sac (Embryonic Structure)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions or duplications of the breast cancer 1 (BRCA1) gene, located at chromosome 17q21, which encodes breast cancer type 1 susceptibility protein. Genetic variants at this locus have been associated with pancreatic cancer, hereditary breast and ovarian cancer syndrome, and familial breast cancer.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, BRCA1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Fracture of proximal end of ulna described as fracture in the proximal half of the shaft of the ulna, with dislocation of the head of the radius.", + "output": "Fracture, Monteggia's (Fracture dislocation of joint of upper limb)" + }, + { + "input": "Definition: Students, Health Occupations described as individuals enrolled in a preparatory course for medical school.", + "output": "Premedical Students (Students, Health Occupations)" + }, + { + "input": "Definition: Characteristic of psychosocial functioning described as the process of successfully managing difficult or challenging situations.", + "output": "coping behavior: (Psychological adjustment)" + }, + { + "input": "Definition: vacuolar transmembrane transport described as the directed movement of basic amino acids out of the vacuole, across the vacuolar membrane.", + "output": "basic amino acid transmembrane export from vacuole (basic amino acid transmembrane transport)" + }, + { + "input": "Definition: something described as a crystalline, inorganic compound composed of beryllium and aluminum in which beryllium increases the alloys thermal and electrical conductivity and emits toxic fumes of beryllium oxides upon heating. Beryllium-aluminum alloy is mainly used in light aircraft construction. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer.", + "output": "Beryllium-Aluminium Alloy (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Sign or Symptom described as a cough that does not produce phlegm or mucus. []", + "output": "cough nonproductive (Lung)" + }, + { + "input": "Definition: something described as an adriamycin-resistant cell line established by Batist, et al., in 1986, intended to be derived from the breast cancer cell line MCF-7. Recent single nucleotide polymorphism array analysis confirmed that the NCI/ADR-RES cell line is not derived from the MCF-7 cell line, but from the ovarian cancer cell line OVCAR-8.", + "output": "NCI/ADR-RES (Experimental Model of Disease)" + }, + { + "input": "Definition: something described as the determination of the amount of CD22 expressing cells per unit present in a sample.", + "output": "CD22 Expressing Cell Count (Laboratory Procedure)" + }, + { + "input": "Definition: Needles, Aspiration/Injection described as needles designed for percutaneous transhepatic injection of fluids and/or percutaneous drainage of the biliary ducts. These devices typically consist of very fine, long, flexible needles that can reach the biliary tree and the common bile duct. These needles are mostly used for percutaneous drainage of bile; they may also be used to inject contrast media.", + "output": "Biliary Duct Aspiration/Injection Needles (Needles, Aspiration/Injection)" + }, + { + "input": "Definition: Zinc-containing product in oral dose form described as a zinc salt of acetic acid essential for the synthesis of cholesterol, protein, and fats. Zinc plays an important role in the proper functioning of the immune system. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing as well as the release of vitamin A from the liver. It plays a role in the acuity of the senses of smell and taste and is required to maintain prostate reproductive health and insulin function. Zinc is also involved in the metabolism of carbohydrates. Zinc acetate is administered orally or parenterally as a nutritional supplement.", + "output": "Dicarbomethoxyzinc (acetic acid)" + }, + { + "input": "Definition: Eimeriorina described as a family of parasitic organisms in the order EIMERIIDA. CRYPTOSPORIDIUM is the most important genus.", + "output": "Family cryptosporiidae (Eukaryote)" + }, + { + "input": "Definition: Occupation or Discipline described as a grouping of sciences including those concerned with the description, prediction, and understanding of natural phenomena, based on empirical evidence from observation and experimentation, as well as those focused on the use of scientific processes and knowledge as the means to achieve a particular practical or useful result.", + "output": "Basic and Applied Science (Occupation or Discipline)" + }, + { + "input": "Definition: Pharmacologic Substance described as an antibody-drug conjugate (ADC) composed of HT-19, a monoclonal antibody directed against the human epidermal growth factor receptor 2 (ERBB2; HER2), conjugated, via a proprietary biodegradable, hydrophilic polymer backbone and various linkers, to proprietary auristatin-derived payload molecules (about 15 per antibody), with potential antineoplastic activity. Upon administration of anti-HER2/auristatin payload ADC XMT-1522, the antibody moiety targets and binds to a unique epitope in the extracellular domain (ECD) of HER2. Upon internalization, cleavage and release of the cytotoxic molecules, the auristatin-derived molecules bind to tubulin and inhibit its polymerization, which results in G2/M phase arrest and induces apoptosis of HER2-expressing tumor cells. The attachment of multiple auristatin molecules to the backbone enables XMT-1522 to effectively kill tumors that express relatively low amounts of the HER2 protein; therefore, this agent shows increased therapeutic potential in tumors with low HER2 expression compared to other anti-HER2 antibody-based therapies. The polymer-based proprietary platform optimizes delivery of the cytotoxic drug payload and improves drug solubility.", + "output": "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522 (Anti-HER2 Antibody-drug Conjugate)" + }, + { + "input": "Definition: Subdivision of lung described as lobular segment, each instance of which is some smaller subdivision of some lung, separated by some connective tissue septum and supplied by a branch of some lobar bronchus.", + "output": "lung segments (Anatomical set)" + }, + { + "input": "Definition: Functional Concept described as the Study Conduct sub-domain is intended for those involved in the execution of a research study. The majority of business requirements have come from those involved in clinical trials. It focuses on the activities of conducting the study as well as the results from those activities.", + "output": "Study Conduct Sub-Domain (Domain)" + }, + { + "input": "Definition: phenylpropanoid biosynthetic process described as the chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids.", + "output": "isoflavonoid biosynthesis (Molecular Function)" + }, + { + "input": "Definition: Pelvis described as permanent fixation of the hip in primary positions, with limited passive or active motion at the hip joint. Locomotion is difficult and pain is sometimes present when the hip is in motion. It may be caused by trauma, infection, or poliomyelitis.", + "output": "hip; contracture (Anatomical Abnormality)" + }, + { + "input": "Definition: S [Preparations] described as an oil obtained from the seed of Butyrospermum parkii. Sheanut oil is used as an ingredient in skincare products.", + "output": "Sheanut oil (S [Preparations])" + }, + { + "input": "Definition: White blood cell analyses described as a measurement of the total plasma cells in a biological specimen.", + "output": "Plasma cell count procedure (Laboratory Procedure)" + }, + { + "input": "Definition: Infant Sedation, Adverse Event described as an adverse event in a newborn characterized by life-threatening sedation with cardiorespiratory instability; requiring urgent care change.", + "output": "Grade 4 Infant Sedation, AE (Infant Sedation, Adverse Event)" + }, + { + "input": "Definition: Anti-PD-L1 Monoclonal Antibody described as a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-L1 monoclonal antibody TG-1501 specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells.", + "output": "TG 1501 (Antineoplastic Antibody)" + }, + { + "input": "Definition: Numbers described as a natural number greater than twenty-nine and less than thirty-one and the quantity that it denotes.", + "output": "Thirty (Natural Number)" + }, + { + "input": "Definition: something described as the approximate intake in one day of niacin.", + "output": "Estimated intake of niacin in 24 hours (Nutrient Intake)" + }, + { + "input": "Definition: something described as any process that increases the frequency, rate, or extent of B cell tolerance induction.", + "output": "positive regulation of macrophage tolerance induction (regulation of macrophage tolerance induction)" + }, + { + "input": "Definition: plastid organization described as the partitioning of plastids between daughter cells at cell division.", + "output": "plastid inheritance (Cell Function)" + }, + { + "input": "Definition: something described as the aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.", + "output": "spindle assembly involved in male meiosis (spindle assembly involved in meiosis)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a procedure in which water or a medicated solution is used to clean the vagina and cervix.", + "output": "douche (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Manufactured Object described as metal closures used on packages where the pressure inside the package is less than atmospheric.", + "output": "Vacuum, Metal (Manufactured Object)" + }, + { + "input": "Definition: Reference ID described as a character or string used to name, or characterize a morphology reference.", + "output": "MOREFID (Reference ID)" + }, + { + "input": "Definition: Functional Concept described as relating to, or performed by, both hands.", + "output": "Bimanual (Functional Concept)" + }, + { + "input": "Definition: Intellectual Product described as the literal identifier of the mononucleotide markers present in an assay kit.", + "output": "Mononucleotide Marker Name (Name)" + }, + { + "input": "Definition: something described as one of two parts of the subparafascicular nucleus of the thalamus identified by internal structure in the macaque ( Paxinos-2009a ), the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ). The other is the magnocellular part of the subparafascicular nucleus.", + "output": "parvicellular part of the subparafascicular nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as care that supports psychosocial functioning and facilitates life style changes", + "output": "Behavioral (Nursing Interventions Classification)" + }, + { + "input": "Definition: Polyesters described as an absorbable suture material used also as ligating clips, as pins for internal fixation of broken bones, and as ligament reinforcement for surgically managed ligament injuries. Its promising characteristics are elasticity, complete biodegradability, and lack of side effects such as infections.", + "output": "Poly(oxy(1-oxo-1,2-ethanediyl)oxy-1,2-ethanediyl) (Biomedical or Dental Material)" + }, + { + "input": "Definition: Ophthalmic viscoelastic preparation described as a semisynthetic, inert, viscoelastic polymer. It is used as an ophthalmic lubricant and as an excipient in oral medications.", + "output": "hydroxypropyl methylcellulose ophthalmic (Ophthalmic viscoelastic agent)" + }, + { + "input": "Definition: suppression by virus of host gene expression described as any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors.", + "output": "suppression by virus of host transcription (suppression by virus of host gene expression)" + }, + { + "input": "Definition: Pathologic Function described as breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.", + "output": "anastomotic leaks (Complication of surgical and medical care, unspecified)" + }, + { + "input": "Definition: something described as the determination of the amount of cystine crystals present in a sample.", + "output": "CYCYSTIN (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as problems that result from storing the device in an uncontrolled or improper environment (e.g. moisture sensitive devices stored in a humid environment).", + "output": "Storage Problem Identified (Device Evaluation Result)" + }, + { + "input": "Definition: oxidoreductase complex described as an enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN).", + "output": "glycolate oxidase complex location (Cell Component)" + }, + { + "input": "Definition: regulation of antigen processing and presentation of peptide antigen via MHC class Ib described as any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.", + "output": "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib (regulation of antigen processing and presentation of peptide antigen via MHC class Ib)" + }, + { + "input": "Definition: Mental Retardation described as a chromosomal disorder with distinctive clinical findings characterised by early central hypotonia, developmental delay and intellectual deficit, epilepsy, and autistic behaviour. Facial dysmorphism is absent or subtle and major malformations are rare. The syndrome is usually sporadic and not inherited and results from an abnormal extra chromosome in each cell containing mirror-image segments of genetic material. The isodicentric chromosome is made up of two extra copies of a segment of genetic material from chromosome 15, which is attached end-to-end. Typically this copied genetic material includes a region of the chromosome called 15q11-q13.", + "output": "Isodicentric 15 chromosome (Seizures and seizure disorders NEC)" + }, + { + "input": "Definition: SIQ-JR Questionnaire Question described as suicidal Ideation Questionnaire-JR - I wished I were dead.", + "output": "SIQ0211 (Intellectual Product)" + }, + { + "input": "Definition: Clostridiales described as a genus of anaerobic, gram-positive bacteria in the family Peptostreptococcacea and the order CLOSTRIDIALES. It is a known cause of DIARRHEA in its most common form Clostridioides difficile, which used to be known as CLOSTRIDIUM DIFFICILE.", + "output": "Clostridioides Lawson et al. 2016 (Clostridiales)" + }, + { + "input": "Definition: Thyroid Gland Papillary Carcinoma by AJCC v8 Stage described as stage III includes: 55 years and older: T4a, Any N, M0. T4a: Gross extrathyroidal extension invading subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve from a tumor of any size. M0: No distant metastasis.", + "output": "Stage III Thyroid Gland Papillary Cancer (Thyroid Gland Papillary Carcinoma by AJCC v8 Stage)" + }, + { + "input": "Definition: something described as insufficient Evidence for Gestational Hypertension is defined by two criteria: first, a pregnancy with gestational age greater than or equal to 20 weeks; second, one or more of the following requirements: a) The inability to measure blood pressure; b) The inability to evaluate for proteinuria.", + "output": "GAIA Insufficient Evidence for Diagnosis of Gestational Hypertension (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.", + "output": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity (amidine-lyase activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as interleukin-27 subunit alpha (243 aa, ~27 kDa) is encoded by the human IL27 gene. This protein is involved in the modulation of angiogenesis, inflammation and tumorigenesis.", + "output": "IL-27-A (Interleukins)" + }, + { + "input": "Definition: Plant described as sandalwood.", + "output": "santalum album (Santalum)" + }, + { + "input": "Definition: Respiratory and cerebral stimulant, NOS described as a substance found in the leaves and beans of the coffee tree, in tea, yerba mate, guarana berries, and in small amounts in cocoa. It can also be made in the laboratory, and is added to some soft drinks, foods, and medicines. Caffeine increases brain activity, alertness, attention, and energy. It may also increase blood pressure, heart rate, breathing rate, and the loss of water from the body in urine.", + "output": "Theine (Food and Nutrition)" + }, + { + "input": "Definition: endocrine laboratory tests nonspecific abnormal findings described as a laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood.", + "output": "endocrine nonspecific abnormal findings blood gonadotropin abnormal (endocrine laboratory tests nonspecific abnormal findings)" + }, + { + "input": "Definition: Finding described as moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL", + "output": "Grade 2 General disorders and administration site conditions - Other, specify (Finding)" + }, + { + "input": "Definition: GAIA Neonatal Infections Level of Diagnostic Certainty described as level 3 Neonatal Invasive Blood Stream Infection is defined by two criteria: first, the criteria does not meet the requirements for level 1 or 2 diagnostic certainty; second, two or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or severe chest indrawing or grunting or cyanosis; c) Change in level of activity; d) History of feeding difficulty; e) History of convulsions.", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 3 Neonatal Invasive Blood Stream Infection (Intellectual Product)" + }, + { + "input": "Definition: something described as a FIGO stage term that applies to gynecologic cancers. For cervical cancer, it refers to invasive cancer that is diagnosed microscopically only. The stromal invasion has a maximum depth of 3.00 mm and a horizontal spread of 7.00 mm or less; there is no FIGO stage IA1 for endometrial cancer.", + "output": "FIGO Stage IA1 (Intellectual Product)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of bite cells (erythrocytes with the appearance of a bite having been removed, due to oxidative hemolysis) to all erythrocytes in a biological specimen.", + "output": "BTECERBC (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Organism Function described as a process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.", + "output": "vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure (Organism Function)" + }, + { + "input": "Definition: Disease or Syndrome described as sparse and small myenteric ganglia []", + "output": "Hypoganglionosis (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a radioconjugate consisting of the octreotide derivative edotreotide labeled with yttrium 90 (Y-90) with potential radiotherapeutic uses. Similar to octreotide, yttrium Y 90-edotreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells, delivering tissue-specific, beta-emitting nuclide Y-90-mediated cytotoxicity to SSTR-positive cells. Yttrium Y 90-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide and chelating the substituted octreotide to Y-90 via dodecanetetraacetic acid (DOTA). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2601\" active clinical trials using this agent.", + "output": "(90Y-DTPA(0), Tyr(3))octreotide (Radioconjugate)" + }, + { + "input": "Definition: Intellectual Product described as inventory of Depressive Symptomatology - Clinician-Rated - Please circle one response to each item that best describes the patient for the last seven days: Concentration/decision making.", + "output": "IDSC1-Concentration/Decision Making (IDS-C Clinical Classification Question)" + }, + { + "input": "Definition: something described as endocardium of ventricle which is continuous with mitral valve , aortic valve, atrioventricular septum and the tunica intima of the aorta.", + "output": "Endocardium of left ventricle (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Finding described as a microscopic finding indicating that more than 5 percent of the nucleated cells in a peripheral leukocyte sample are neoplastic plasma cells.", + "output": "Neoplastic Plasma Cells More than 5 Percent of Peripheral Blood White Cells (Finding)" + }, + { + "input": "Definition: Abnormal Blood Chemistry and Hematology Test Result described as abnormally high level of prolactin in the blood.", + "output": "Increased circulating prolactin concentration (Hyperpituitarism)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective answer of very mild agreement regarding the importance of something.", + "output": "A little important (Intellectual Product)" + }, + { + "input": "Definition: Chromosome 12 Physical Location described as physical location of FRS2_Gene", + "output": "12: 68150453-68255011 (Chromosome 12 Physical Location)" + }, + { + "input": "Definition: Induced Hyperthermia described as therapy of sitting in a hot steamy room followed by a cool bath or shower.", + "output": "steam bath (Induced Hyperthermia)" + }, + { + "input": "Definition: Stroma described as stroma between glomerular capillaries or between glomerular capillaries and macula densa.", + "output": "Glomerular mesangium (Body tissue)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had an unsatisfactory diet due to problems with teeth, denture or mouth.", + "output": "Because of problems with your teeth, denture or mouth have you had an unsatisfactory diet (Findings-Based Question)" + }, + { + "input": "Definition: Finding described as choroidal and ciliary body melanoma, tumor size category 4 with ciliary body involvement.", + "output": "Choroidal and Ciliary Body Melanoma pT4b TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as a question about whether others are irritated by an individual's eating problem.", + "output": "Others Irritated by My Eating Problem (Findings-Based Question)" + }, + { + "input": "Definition: Phenoxyacetates described as an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.", + "output": "Centrophenoxine (Pharmacologic Substance)" + }, + { + "input": "Definition: General signs and symptoms NEC described as an increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).", + "output": "Increased fat tissue (Increased connective tissue)" + }, + { + "input": "Definition: Abnormal neuron morphology described as any structural anomaly that affects the motor neuron. []", + "output": "Abnormal shape of motor neuron (Abnormal neuron morphology)" + }, + { + "input": "Definition: Cell described as a preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) were ex vivo manipulated, using a technique involving membrane disruption to get the HPV16 E6 and E7 proteins into the cells; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner. Upon administration of the APCs-expressing HPV16 E6/E7 SQZ-PBMC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7. HPV16 E6 and E7 play an important role in the development of certain types of cancer.", + "output": "SQZ PBMC HPV (Cancer Vaccines)" + }, + { + "input": "Definition: Design, construction and building products and technology of buildings for private use described as indoor and outdoor products and technology for private use to assure safety, such as guardrails, emergency signals and secure storage of hazardous objects (e.g. weapons) or materials (e.g. solvents, insecticides).", + "output": "Design, construction and building products and technology for physical safety of persons in buildings for private use (Manufactured Object)" + }, + { + "input": "Definition: Immunology analyte described as factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.", + "output": "Macrophage Activating Factors (Immunology analyte)" + }, + { + "input": "Definition: Books, Illustrated described as works about book-length narratives told using a combination of words and sequential art, often presented in comic book style.", + "output": "Manga as Topic (Intellectual Product)" + }, + { + "input": "Definition: something described as this syndrome is characterized by mild to borderline intellectual deficit associated with cleft lip/palate. Preaxial polydactyly, large hands and cryptorchidism are sometimes present. The syndrome has been described in seven boys from two families. Transmission is X-linked and the syndrome is caused by mutations in the PHF8 gene, localized to the p11.21 region of the X chromosome.", + "output": "X-linked intellectual disability Siderius type (Gene mutations and other alterations NEC)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part I. Over the past 7 days, how short of breath did you get with each of these activities?: Sweeping or mopping.", + "output": "FAC08411 (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)" + }, + { + "input": "Definition: something described as human CYP3A7*2 allele is located within 7q21-q22.1 and is approximately 30 kb in length. This allele, a variant form of the human CYP3A7 wild-type allele, encodes cytochrome P450 3A7*2 protein. This allele exhibits a clinically-relevant SNP (c.1226C>G) in exon 11 that results in a T409R coding change. This alteration in protein sequence increases the enzymatic activity of the cytochrome P450 3A7*2 protein.", + "output": "Cytochrome P450, Family 3, Subfamily A, Polypeptide7*2 Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as bedside scales designed to weigh the patient by lifting him or her from the bed. These scales consist of a slablike padded board that the patient is rolled onto. The board is suspended by metal brackets from a cart that includes the lift mechanism (e.g., hydraulic, electrical), weighing unit, controls, and a display. Activating the lift mechanism raises the board and patient slightly off the bed, weighing nonambulatory patients with minimum discomfort.", + "output": "Slab Scales (Medical Device)" + }, + { + "input": "Definition: Natural Phenomenon or Process described as physical resistance to motion between dental surfaces.", + "output": "Orthodontic Friction (Biomechanical Phenomena)" + }, + { + "input": "Definition: something described as this gene plays a role in transcriptional regulation of genes which are required for development of ectodermal tissues.", + "output": "AP2-GAMMA (Transcription factor genes)" + }, + { + "input": "Definition: something described as surgical replacement and/or repair of a cardiac valve, by any approach. This includes percutaneous valve procedures and valvuloplasty.", + "output": "Cardiac Valve Procedure (Cardiac therapeutic procedures)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle.", + "output": "metanephric descending thin limb development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as the coronary sinus / left ventricular lead was not implanted because the operator was unable to obtain satisfactory vascular access.", + "output": "UNABLE TO OBTAIN SATISFACTORY VASCULAR ACCESS (Finding)" + }, + { + "input": "Definition: Qualitative abnormality of granulocyte described as a congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.", + "output": "Histiocytosis, Sea-Blue (Abnormal macrophage morphology)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum) to determine prolactin (PRL), a hormone secreted by the anterior lobe of the pituitary gland that stimulates and sustains lactation. High levels of prolactin (also known as lactogen) are found in pregnant women and also in women with minor alterations of fertility, such as absence of ovulation with or without menstrual irregularity or abnormal secretion of milk (galactorrhea). The level of prolactin also increases in some diseases, including pituitary adenoma, and after the administration of some drugs (e.g., tricyclic antidepressants).", + "output": "IVD Test Reagent/Kits, Immunoassay, Fertility Hormone, Prolactin (Medical Device)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the thrombin time in a subject's specimen when compared to a control specimen.", + "output": "Thrombin Time Actual to Control Ratio Measurement (Thrombin Time Assay)" + }, + { + "input": "Definition: something described as a lymph node at the ileocecocolic junction.", + "output": "LYMPH NODE, ILEOCECOCOLIC (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: epidemiologic described as used with diseases for ethnic, cultural, or anthropological aspects, and with geographic headings to indicate the place of origin of a group of people.", + "output": "ETHNOL (epidemiologic)" + }, + { + "input": "Definition: HAQ-DI Questionnaire Question described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale - Aids or devices that you usually use for any of these activities: Long-handled appliances in bathroom.", + "output": "HAQ-DI With VAS - Aids or Devices - Long-Handled Appliances in Bathroom (HAQ-DI Questionnaire Question)" + }, + { + "input": "Definition: Receptor described as t-cell surface antigen CD2 (351 aa, ~39 kDa) is encoded by the human CD2 gene. This protein plays a role in both T-cell activation and T-cell adhesion to other cells.", + "output": "LFA-3 Receptor (Specific antigen)" + }, + { + "input": "Definition: Short 2nd finger described as hypoplasia (congenital reduction in size) of the proximal phalanx of the second finger.", + "output": "Short proximal phalanx of the 2nd finger (Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger)" + }, + { + "input": "Definition: Surgical sutures described as small forceps with scissorlike handles, used to grasp, hold, and exert traction or compression on a specimen during dissection. Their blades are typically finely pointed and serrated. They are generally used in surgery and oncology.", + "output": "Forceps, Dissecting (Forceps)" + }, + { + "input": "Definition: Abnormal hemoglobin, delta-chain variant described as hemoglobin subunit zeta (142 aa, ~16 kDa) is encoded by the human HBZ gene. This protein plays a role in the transport of oxygen to tissues of the embryo.", + "output": "Zeta-chain haemoglobin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as group of polysaccharides composed of repeating glucose units; they can consist of branched or unbranched chains in any linkages.", + "output": "glucose polymers (hexosan)" + }, + { + "input": "Definition: something described as removal or sampling of lymph nodes in the supraclavicular area.", + "output": "Supraclavicular lymph node biopsy (Biopsy of lymph node)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure for the area under an effect curve (AUEC) defined as hours times percent.", + "output": "Hour Times Percent (Miscellaneous Unit)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Summary score for commands.", + "output": "Commands (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: Negative Regulation of Lymphocyte Activation described as any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.", + "output": "down regulation of T cell activation (Negative Regulation of Lymphocyte Activation)" + }, + { + "input": "Definition: Physical shape described as an accumulation of cell fragments.", + "output": "Cellular Debris (Finding)" + }, + { + "input": "Definition: Germ-Line Mutation described as a molecular finding indicating that the immunoglobulin heavy chain variable region has an unmutated germline configuration.", + "output": "Unmutated Immunoglobulin Heavy Chain Variable Region Gene (Germ-Line Mutation)" + }, + { + "input": "Definition: T1-DDS Questionnaire Question described as diabetes Distress Scale for Adults with Type 1 Diabetes (T1-DDS) Over the past month, please indicate the degree to which each of the following may have been a problem for you: Feeling that I don't notice the warning signs of hypoglycemia as well as I used to.", + "output": "T1-DDS - Don't Notice Signs of Hypoglycemia (Intellectual Product)" + }, + { + "input": "Definition: cellular developmental process described as the process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex.", + "output": "stomatal lineage progression (cellular developmental process)" + }, + { + "input": "Definition: something described as gastrointestinal Secretory Induction involves stimulation of oral, gastric, or intestinal fluid release from cells into the lumen of the gastrointestinal (GI) tract. Stimulation aids digestion and absorption of nutrients as well as protection and lubrication of the GI tract.", + "output": "Gastrointestinal Secretory Induction (Gastrointestinal Process)" + }, + { + "input": "Definition: Governmental or Regulatory Activity described as governmental bodies that have the power to pass and enforce laws. EXAMPLE(S): Medicines and Healthcare Products Regulatory Agency (MHRA) in the UK, Food and Drug Administration (FDA) in the USA OTHER NAME(S): NOTE(S):", + "output": "RegulatoryAuthority (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Croatian translation of the Medical Subject Headings described as the organs that take in food and turn it into products that the body can use to stay healthy. Waste products the body cannot use leave the body through bowel movements. The digestive system includes the salivary glands, mouth, esophagus, stomach, liver, pancreas, gallbladder, small and large intestines, and rectum.", + "output": "gastrointestinal system (International Classification of Primary Care)" + }, + { + "input": "Definition: Intellectual Product described as a coded value that represents a special handling requirement for the labeled material or object.", + "output": "handlingCode (Code)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cyclin-A2 (432 aa, ~49 kDa) is encoded by the human CCNA2 gene. This protein is involved in the regulation of both the cell cycle and mitosis.", + "output": "Cyclin-A2 (Biologically Active Substance)" + }, + { + "input": "Definition: Plant described as a plant genus of the family APOCYNACEAE. It is a very poisonous plant that contains cardioactive agents.", + "output": "Nerium, NOS (Apocynaceae)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was always able to express concerns to their doctor and get the needed information or advice.", + "output": "Always Able to Express Concerns to Doctor and Get Needed Information or Advice (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Anesthesia/Respiratory Equipment and Supplies described as devices intended to be used with nebulizers or metered-dose inhalers (MDIs) for the purpose of minimizing the delivery of large aerosolized particles, thereby increasing the percentage of inhaled medication that reaches the lower airways. Inhalation spacers typically consist of a tube-shaped reservoir that connects to the outlet of the nebulizer/MDI at its distal end and to the patient's mouth at the proximal end. Some inhalation spacers, termed valved holding chambers, incorporate a one-way valve that aids in regulating inspiratory flow and prevents patients from exhaling into the device.", + "output": "Inhalation Spacer (Medical Device)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT Version 4) I am content with the quality of my life right now.", + "output": "FACT-BMT Version 4 - Content With Quality of My Life (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Gene or Genome described as human PSMC2 wild-type allele is located within 7q22.1-q22.3 and is approximately 25 kb in length. This allele, which encodes 26S protease regulatory subunit 7 protein, plays a role in both ATP hydrolysis and the modulation of proteasomal activity.", + "output": "PSMC2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as a synthetic, gray-white crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect). It is one of the most abundant heterocyclic amines in a typical Western diet. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen.", + "output": "2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (Organic Chemical)" + }, + { + "input": "Definition: something described as an operating body of the UNITED NATIONS, responsible for coordinating international cooperation in education, science, culture and communication.", + "output": "United Nations Educational, Scientific and Cultural Organization (Organization)" + }, + { + "input": "Definition: Central Nervous System Stimulants described as a synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury.", + "output": "TALAMPANEL (Organic Chemical)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene plays a role in the replication of mitochondrial DNA.", + "output": "POLG, CATALYTIC SUBUNIT (Gene or Genome)" + }, + { + "input": "Definition: beta-glucan catabolic process described as the chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans.", + "output": "1,3-beta-glucan catabolism (Molecular Function)" + }, + { + "input": "Definition: Eicosanoid Production described as leukotriene Production consists of synthesis of a family of oxidative derivatives of arachidonic acid (5-lipoxygenase pathway) (leukotrienes) having potent regulatory effects on the activity of cardiovascular, pulmonary, central neural, gastrointestinal, and immune system cells involved in host defense, immediate hypersensitivity, and inflammation.", + "output": "Leukotriene Production (Eicosanoid Production)" + }, + { + "input": "Definition: Pharmacologic Substance described as one of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine.", + "output": "IFN beta 2 (Pharmacologic Substance)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a tri-Fab bispecific monoclonal antibody (BiMoAb) divalent for the carcinoembryonic antigen (CEA) and monovalent for histamine-succinyl-glycine (HSG) peptide-hapten. Anti-CEA/anti-HSG bispecific monoclonal antibody TF2 binds to the tumor associated antigen (TAA) CEA on CEA-expressing tumor cells. Subsequently, an HSG peptide-hapten carrying a radionuclide is administered, binding to the anti-HSG binding fragment on the BiMoAb. Depending on the characteristics of the radionuclide used, CEA-expressing tumor cells may then be radioimaged and/or treated radioimmunotherapeutically.", + "output": "TF2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as patient positioning aids designed to keep patients lying on one side while sleeping to help in the treatment of positional obstructive sleep apnea and/or snoring. These devices typically consist of a soft material (e.g., foam) cushion covered with one or more layers of plastics or fabrics. The device is worn on the back of the patient using appropriate belts or straps to secure it to the body. Side-sleeping positioning aids allow patients to sleep on one side but prevent sleeping on the supine position.", + "output": "Patient Positioning Aids, Obstructive Sleep Apnea/Anti-Snoring, Side-Sleeping (Medical Device)" + }, + { + "input": "Definition: Therapeutic radiology and nuclear medicine described as a type of radiation therapy that uses x-rays or gamma rays that come from a special machine called a linear accelerator (linac). The radiation dose is delivered at the surface of the body and goes into the tumor and through the body. Photon beam radiation therapy is different from proton beam therapy.", + "output": "electron beam therapy (Therapeutic radiology and nuclear medicine)" + }, + { + "input": "Definition: Functional Concept described as an interruption in clinical trial activity by the sponsor that is not in the clinical protocol, with an intention to resume the study.", + "output": "temporary halt (Functional Concept)" + }, + { + "input": "Definition: Venous malformation described as total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium.", + "output": "TAPVR (Total anomalous pulmonary venous return)" + }, + { + "input": "Definition: methanol metabolic process described as the chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.", + "output": "methanol formation (primary alcohol biosynthetic process)" + }, + { + "input": "Definition: Parental state described as a female full sibling that developed from a separately fertilized ova during the same pregnancy.", + "output": "fraternal twin sister (Twins, Dizygotic)" + }, + { + "input": "Definition: Immunotoxins described as an immunoconjugate consisting of a humanized monoclonal antibody against the tumor-associated sialoglycotope CA6 (huDS6) conjugated to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-CA6 monoclonal antibody moiety of SAR566658 targets and binds to the cell surface antigen CA6. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CA6-expressing tumor cells. The CA6 epitope is found on a variety of solid tumors, including breast, ovarian, cervical, lung and pancreatic tumors.", + "output": "SAR566658 (Immunotoxins)" + }, + { + "input": "Definition: Enzyme described as a ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.", + "output": "Branched Chain Oxo Acid Dehydrogenase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a surgical technique that uses a specially designed robotic system to aid removal of pelvic lymph nodes after failure of initial surgery or other treatment modalities.", + "output": "Robot-assisted Salvage Pelvic Lymph Node Dissection (Salvage Surgery)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of normal cells compared to total cells present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "NORMCECE (Cell Count)" + }, + { + "input": "Definition: Lower Urinary Tract Symptoms described as frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).", + "output": "Nocturnal frequency (Genitourinary Signs and Symptoms)" + }, + { + "input": "Definition: Unit of volume described as a traditional unit of liquid volume equal in the US customary system to 1/16 pint, or 1.804 687 cubic inches or 29.573 531 milliliters.", + "output": "FO (Non-SI unit of volume)" + }, + { + "input": "Definition: something described as a fusion protein encoded by the TCF3/PBX1 fusion gene. This protein is comprised of the N-terminal transactivation domains of the transcription factor E2-alpha protein fused to the C-terminal DNA binding homeodomain of the pre-B-cell leukemia transcription factor 1 protein.", + "output": "E2A-Pbx1 oncogene protein, fusion (Fusion protein)" + }, + { + "input": "Definition: Biologically Active Substance described as chlorophyll-containing membrane protein which mediates photosynthetic light capture and electron transfer in the cyanobacteria, green sulfur bacteria, purple bacteria, and chloroplasts of plants and green algae; the purple bacteria RC is an integral membrane protein whose X-ray structure is known.", + "output": "Reaction Centers, Photosynthetic (Biologically Active Substance)" + }, + { + "input": "Definition: something described as the result or product of multiplying dimensions (2 or 3) of a site or specimen. EXAMPLE(S): OTHER NAME(S): NOTE(S): Derived from multiplying at least two (2) of the following: PerformedLesionDescription.xDimension, PerformedLesionDescription.yDimension, PerformedLesionDescription.zDimension.", + "output": "Performed Lesion Description Dimension Product (Dimension Product)" + }, + { + "input": "Definition: something described as the patient will be admitted into a medical center and receive a type of hospital bed that will be paid for my Medicare.", + "output": "HOSPITAL-BASED MEDICARE-APPROVED SWING BED (Health care facility)" + }, + { + "input": "Definition: Binding Proteins described as PDZ and LIM domain protein 4 (330 aa, ~35 kDa) is encoded by the human PDLIM4 gene. This protein may play a role in bone development.", + "output": "LIM Domain Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Abnormality of the head described as an abnormality of a blood vessel of the head, including branches of the arterial and venous systems of the head.", + "output": "Abnormality of vasculature of head (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as a delayed response interval occurring when two stimuli are presented in close succession.", + "output": "Refractory Periods, Psychological (Mental Process)" + }, + { + "input": "Definition: High monounsaturated fat diet described as increase in monounsaturated fat content of the diet compared to the assessed baseline intake of monounsaturated fat for the individual.", + "output": "High monounsaturated fat diet (Diet, High-Fat)" + }, + { + "input": "Definition: Moraceae described as a plant genus of the family MORACEAE. Members contain maclurin, antifungal chalcones, and other compounds.", + "output": "Maclura, NOS (Plant)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.", + "output": "nucleoside kinase activity (Molecular Function)" + }, + { + "input": "Definition: cellular anatomical entity described as the polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes.", + "output": "lysosomal glycocalyx (Cell Component)" + }, + { + "input": "Definition: Organic Chemical described as a complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.", + "output": "AGAR, UNSPECIFIED (A [Preparations])" + }, + { + "input": "Definition: Genetic Function described as a triplet codon-amino acid adaptor activity that recognizes an AGU codon.", + "output": "AGT codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: Nucleotide Sequence described as an inherited single base change at a donor splice site in a genomic DNA sequence that results in an allelic variant of the wild-type gene. Donor splice sites are located at exon to intron junctions at the 5' end of the intron.", + "output": "Intronic, Donor Splice Site SNP (Nucleotide Sequence)" + }, + { + "input": "Definition: Concept model rule strength described as MRCM reference set attribute value which indicates that the given rule is mandatory, and not obeying this rule should result in an error.", + "output": "Mandatory concept model rule (Concept model rule strength)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as beclin-2 (431 aa, ~48 kDa) is encoded by the human BECN2 gene. This protein is involved in both autophagy and the catabolism of G protein-coupled receptors.", + "output": "Beclin-1-Like Protein 1 (Biologically Active Substance)" + }, + { + "input": "Definition: Lamiaceae described as a plant genus of the LAMIACEAE family that contains marrubiin (a labdane diterpene). It is known as a traditional medicinal for sore throat.", + "output": "Horehound (Marrubieae)" + }, + { + "input": "Definition: Eye described as a morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination.", + "output": "Abnormality of the optic disc (Abnormality of the optic nerve)" + }, + { + "input": "Definition: something described as catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone.", + "output": "AcuC (histone deacetylase activity)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.", + "output": "negative regulation of immune response to tumor cell (regulation of immune response to tumor cell)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Escherichia albertii.", + "output": "Escherichia albertii Huys et al. 2003 (Bacterium)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).", + "output": "inositol 1,3,4-trisphosphate 6-kinase activity (inositol trisphosphate kinase activity)" + }, + { + "input": "Definition: Watercraft described as large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.", + "output": "Ships (Watercraft)" + }, + { + "input": "Definition: electrode described as a non-sterile electrical conductor designed to be applied to an adult patient for automatic or manual defibrillation, external pacing, cardioversion, and electrocardiographic monitoring through transmission of cardiac bioelectric signals (typically from the thoracic surface) to devices that record/process the signals and potentially return electrical impulses [e.g. electrocardiograph, electrocardiographic monitor(s), defibrillator]. It is a disk-like electrode that is affixed to the skin with a special adhesive and a conductive gel (pre-gelled). It may be made of x-ray translucent materials and may include permanently attached lead wires.", + "output": "External cardiac electrode (Medical Device)" + }, + { + "input": "Definition: Melanocytic nevus of skin described as a congenital vascular malformation consisting of superficial and deep dilated capillaries in the skin which produce a reddish to purplish discolouration of the skin.", + "output": "portwine stain (Cutaneous capillary malformation)" + }, + { + "input": "Definition: Laboratory or Test Result described as an indication that the expression of a fusion involving ALK has not been detected in a sample.", + "output": "Anaplastic Lymphoma Kinase Receptor Fusion Negative (Laboratory or Test Result)" + }, + { + "input": "Definition: regulation of Wnt signaling pathway, calcium modulating pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).", + "output": "downregulation of frizzled-2 signaling pathway (negative regulation of non-canonical Wnt signaling pathway)" + }, + { + "input": "Definition: Samydeae described as a plant genus of the family SALICACEAE. Members contain casearins which are clerodane-type DITERPENES.", + "output": "Casearia (Plant)" + }, + { + "input": "Definition: something described as a microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease.", + "output": "GRAM NEGATIVE IDENTIFICATION PANEL (Medical Device)" + }, + { + "input": "Definition: something described as analyzing a client/patient's blood, hair, urine and/or other sample to assess his or her environmental chemical levels using an ELISA/ACT(R) Screening Environmental Chemical Block 30. Service is billed per test.", + "output": "ELISA/ACT(R) Screening Environmental Chemical Block 30 each test (Chemical analysis)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported - If you answered \"no\" to Question 50 above, was your activity limited by: Activity not in season?", + "output": "PODCI356 (Intellectual Product)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the PARP2 gene.", + "output": "Poly(ADP-Ribose) Polymerase 2 Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Eukaryotic Initiation Factors described as a protein complex comprised of 13 nonidentical subunits (EIF3A-M) that is involved in translation initiation and the disassembly and recycling of post-termination ribosomal complexes.", + "output": "PEPTIDE INITIATION FACTOR EIF 03 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Organic Chemical described as a second-generation sulfonylurea with antihyperglycemic activity. Glypinamide, also called azepinamide, is a chlorinated analogue of tolazamide.", + "output": "Glypinamide (Pharmacologic Substance)" + }, + { + "input": "Definition: UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Rigidity-arms, right.", + "output": "UHDR1-Rigidity: Arms: Right (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: T [Preparations] described as antibacterial used in combination with a sulfonamide to treat some urinary tract infections and pneumocystis pneumonia, and alone as an antimalarial.", + "output": "Trimethoprimum (Antibiotic)" + }, + { + "input": "Definition: Finding described as limited ability to straighten the arm at the elbow joint.", + "output": "Limited elbow extension (Finding)" + }, + { + "input": "Definition: Long-term exploratory psychotherapy described as psychotherapeutic study of thoughts, emotions, and behavior using free association to reveal unconscious conflicts, symbolism, or motivation.", + "output": "Psychoanalysis, NOS (Psychiatric therapeutic procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody against a tumor-associated antigen (TAA) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration of tamrintamab pamozirine, the monoclonal antibody moiety of SC-003 targets and binds to the TAA expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the TAA-expressing cancer cells, through an as of yet unknown mechanism of action.", + "output": "Immunoglobulin G1(226-serine), Anti-(Human Dipeptidase 3)(Human-mus musculus Monoclonal sc34.28SS1 Gamma1-chain), Compd. with Human-mus musculus Monoclonal sc34.28SS1 Kappa-chain, Dimer, Bis(thioether) with N-(6-(3-mercapto-2, 5-dioxo-1-pyrrolidinyl)-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Finding of body region described as an autosomal dominant form of dysplasia that is characterized by progressive thickening of diaphyseal cortex of long bones. Mutations in the gene that encodes TRANSFORMING GROWTH FACTOR BETA1 are one cause of this disorder.", + "output": "Osteopathia hyperostotica scleroticans multiplex infantis (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Biologically Active Substance described as virulence factors of pathogenic plant bacteria, such as XANTHOMONAS species, that bind to specific sequences in the PROMOTER REGIONS of host DNA to induce transcription of specific host genes. Variations in the DNA binding domain of TALE family members account for the variations in DNA specificity. The TALE DNA-binding domains are used in various GENETIC TECHNIQUES by fusing them with various DNA modifying enzymes to detect and manipulate sequence-specific targeted DNA sites.", + "output": "TAL Effectors (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Abnormality of the upper limb described as amniotic constriction rings affecting the arms.", + "output": "Amniotic constriction rings of arms (Congenital Abnormality)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify gene variants associated with susceptibility to periodontal disease (i.e., gum disease), a chronic infection of the tissues surrounding the teeth. Genetic variants at multiple loci have been associated with susceptibility to periodontal disease. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple periodontal disease susceptibility loci simultaneously.", + "output": "Periodontal Disease Susceptibility Gene Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Hematology described as anemia featuring pale erythrocytes smaller than 6 microns in diameter; typically due to iron deficiency or abnormalities in hememetabolism.", + "output": "hypochromic microcytic anemia (Hypochromic anemia)" + }, + { + "input": "Definition: Medical History described as a record of a patient's medical background regarding the occurrence of cancer and cancer-related problems.", + "output": "Individual Cancer History (Finding)" + }, + { + "input": "Definition: something described as testicular cancer in which the primary tumor cannot be assessed.", + "output": "Testicular Cancer pTX TNM Finding v8 (Testicular Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of mexiletine (an antiarrhythmia agent similar in structure and action to lidocaine that is typically used in the treatment of ventricular arrhythmias, such as life-threatening ventricular tachycardias) present in the sample. These reagents are used in tests intended to monitor mexiletine drug levels in patients undergoing treatment to determine the adequacy of therapy or to diagnose a drug-overdose or drug-related toxicity.", + "output": "IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Mexiletine (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular)" + }, + { + "input": "Definition: Nasopharynx described as a collection of lymphoid nodules on the posterior wall and roof of the NASOPHARYNX.", + "output": "Pharyngeal Tonsils (Healthcare Issues for Children and Teenagers)" + }, + { + "input": "Definition: something described as an arbitrary unit of substance rate expressed in unit(s) per square meter per period of time equal to sixty minutes.", + "output": "{U}/m2/h (Quantitative Concept)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify species of Chlamydophila, a genus of intracellular bacteria of the family Chlamydiaceae, by detecting specific genetic information of the ribonucleic acid of the target bacteria. Chlamydophila may cause respiratory infections, mild atypical pneumonia, and/or psittacosis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila Species (Medical Device)" + }, + { + "input": "Definition: something described as an abnormality of an inferior rectus extraocular muscle.", + "output": "Abnormality of inferior rectus extraocular muscle (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Dining out.", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Limit: Dining Out (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Negative Regulation of Cell Differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation.", + "output": "negative regulation of antipodal cell differentiation (Negative Regulation of Cell Differentiation)" + }, + { + "input": "Definition: Finding described as an indication that a the surfaces of cells in sample have detectable amounts of a glycosylated mucin-1 protein (MUC1) that includes a cancer-specific truncated O-glycan modification.", + "output": "Tumor Antigen TnMUC1 Positive Neoplastic Cells Present (MUC1 Positive)" + }, + { + "input": "Definition: something described as an abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles", + "output": "Friction rub, pleural (Respiratory signs and symptoms NEC)" + }, + { + "input": "Definition: something described as harm or hurt to the ankle or ankle joint usually inflicted by an external source.", + "output": "ankle injury (Injury of lower leg)" + }, + { + "input": "Definition: something described as elastic cartilage of the pharyngotympanic tube from isthmus to pharyngeal orifice; together with the isthmus segment of cartilage of pharyngotympanic tube, it constitutes cartilage of pharyngotympanic tube.", + "output": "Cartilage proper of pharyngotympanic tube (Tissue)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus.", + "output": "cellular response to prostaglandin F stimulus (Cell Function)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.", + "output": "Peyer's patch development (Organ or Tissue Function)" + }, + { + "input": "Definition: channel activity described as enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive.", + "output": "channel-forming ionophore activity (Molecular Function)" + }, + { + "input": "Definition: nitrogen compound metabolic process described as the chemical reactions and pathways involving a reactive nitrogen species.", + "output": "RNS metabolic process (Physiologic Function)" + }, + { + "input": "Definition: tumor necrosis factor superfamily cytokine production described as the appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "tumor necrosis factor (ligand) superfamily member 11 production (tumor necrosis factor superfamily cytokine production)" + }, + { + "input": "Definition: something described as stage II includes: IIA (T1, N1, M0) and IIB (T2, N1, M0) or (T3, N0, M0). T1: Tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus. T2: Tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung. T3: Tumor (of any size) directly invades any of the following: chest wall (including superior sulcus tumors), diaphragm, mediastinal pleura, parietal pericardium; or tumor in the main bronchus less than 2 cm distal to the carina but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung. N0: No regional lymph node metastasis. N1: Metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, and intrapulmonary nodes including involvement by direct extension of the primary tumor. M0: No distant metastasis.", + "output": "Stage II Carcinoma of Lung AJCC v6 (Lung Cancer by AJCC v6 Stage)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide.", + "output": "linear malto-oligosaccharide phosphorylase activity (Molecular Function)" + }, + { + "input": "Definition: Area Under Curve described as the area under the curve (AUC) extrapolated to infinity, calculated using the observed value of the last non-zero concentration, divided by the body mass index.", + "output": "AUC Infinity Observed Normalized by Body Mass Index (Quantitative Concept)" + }, + { + "input": "Definition: Reduced visual acuity described as diminished clarity of vision despite optimal optical correction (glasses and/or contacts).", + "output": "Decreased best corrected visual acuity (Eye)" + }, + { + "input": "Definition: something described as a relative measurement (ratio) of the albumin to the creatinine in a biological specimen.", + "output": "albumin creatinine (Laboratory Procedure)" + }, + { + "input": "Definition: Body Location or Region described as the aspect of the nasopharyngeal wall that is located on the side. It contains the pharyngeal opening of the auditory tube.", + "output": "lateral wall of nasopharynx (Nasopharyngeal wall)" + }, + { + "input": "Definition: Health Care Activity described as assessing the health status of a new massage therapy client in a detailed, 30-minute, in-office meeting to develop a treatment plan for somatic education, massage therapy and/or bodywork.", + "output": "new30min inofc msg therp nta (New client in-office without ICD diagnosis)" + }, + { + "input": "Definition: Disease or Syndrome described as chronic nonsuppurative inflammation of periapical tissue resulting from irritation following pulp disease or endodontic treatment.", + "output": "Periapical Granulomas (Periapical Periodontitis)" + }, + { + "input": "Definition: Research Activity described as to take or register the number of votes or opinions.", + "output": "demographic study (Research Activity)" + }, + { + "input": "Definition: regulation of nuclear migration during mitotic telophase described as any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase.", + "output": "down-regulation of nuclear migration during mitotic telophase (negative regulation of nuclear migration along microtubule)" + }, + { + "input": "Definition: Abnormality of the palm described as for children from birth to 4 years of age, the palm width is more than 2 SD below the mean; for children from 4 to 16 years of age the palm width is below the 5th centile; or, the width of the palm appears disproportionately narrow for its length.", + "output": "Narrow palm (Finding)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 3 Months Version - These are questions about what activities usually make you feel short of breath these days: Walking up a flight of stairs.", + "output": "SGRQ0116 (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in the negative regulation of gene transcription.", + "output": "GON4 (Transcription Regulation Gene)" + }, + { + "input": "Definition: something described as reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).", + "output": "Reduced factor X activity (Abnormality of the common coagulation pathway)" + }, + { + "input": "Definition: regulation of cold-induced thermogenesis described as any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.", + "output": "positive regulation of cold-induced thermogenesis (regulation of cold-induced thermogenesis)" + }, + { + "input": "Definition: Bodily secretions described as thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins; consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.", + "output": "Col (Body Substance)" + }, + { + "input": "Definition: Carcinogenesis described as the process by which normal skin cells are transformed into cancer cells.", + "output": "Skin Carcinogenesis (Neoplastic Process)" + }, + { + "input": "Definition: something described as human FCGR2A wild-type allele is located within 1q23 and is approximately 14 kb in length. This allele, which encodes low affinity immunoglobulin gamma Fc region receptor II-a protein, plays a role in receptor signal transduction and may be involved in collagen-mediated platelet activation.", + "output": "FCG2 (FCGR2A gene)" + }, + { + "input": "Definition: Disease or Syndrome described as a type of multiple sclerosis characterized by intermittent flare-ups with a return to few or no symptoms.", + "output": "Relapsing-remitting multiple sclerosis (Multiple Sclerosis)" + }, + { + "input": "Definition: Enterobacteriaceae described as any bacterial organism that can be assigned to the species Salmonella enterica subspecies arizonae.", + "output": "Paracolobactrum arizonae (Enterobacteriaceae)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the monocytoid cells to total cells in a biological specimen.", + "output": "Monocytoid Cells/Total Cells (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: modulation by symbiont of host immune response described as the process in which a virus effects a change in the host immune response.", + "output": "modulation by virus of host immune response (modulation by virus of host cellular process)" + }, + { + "input": "Definition: something described as a question associated with the FOSI questionnaire.", + "output": "FOSI Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Reusable Devices described as an orthopedic manual surgical instrument is a nonpowered hand-held device intended for medical purposes to manipulate tissue, or for use with other devices in orthopedic surgery. This generic type of device includes the cerclage applier, awl, bender, drill brace, broach, burr, corkscrew, countersink, pin crimper, wire cutter, prosthesis driver, extractor, file, fork, needle holder, impactor, bending or contouring instrument, compression instrument, passer, socket positioner, probe, femoral neck punch, socket pusher, reamer, rongeur, scissors, screwdriver, bone skid, staple driver, bone screw starter, surgical stripper, tamp, bone tap, trephine, wire twister, and wrench.", + "output": "TREPHINE (Reusable Devices)" + }, + { + "input": "Definition: Organic Chemical described as a substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.", + "output": "CEDIRANIB MALEATE (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as viruses whose nucleic acid is DNA.", + "output": "DNA viruses (Vertebrates--Viruses)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis.", + "output": "labial disc metamorphosis (Organ or Tissue Function)" + }, + { + "input": "Definition: Ketones described as a dietary supplement isolated from soybeans containing phytoestrogen isoflavones. Although the mechanism of action is unclear, soy isoflavones mimic estrogen action mediated through estrogen receptors. In addition, this agent also modulates estrogen metabolism. As a result, soy isoflavones have been shown to reduce tumor cell proliferation and induce tumor cell apoptosis, as well as to be able to regulate hormone balance and reduce the risks of breast cancer, heart disease, and osteoporosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65152\" active clinical trials using this agent.", + "output": "Soybean Isoflavone Mixture (Soybeans)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in degradation of proteoglycans and fibronectin.", + "output": "SL2 (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 - Do you need to stay in bed or a chair during the day?", + "output": "EORTC QLQ-C30 Version 3 - Stay in Bed or Chair During the Day (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: Cirrhosis described as a type of cirrhosis characterized by the presence of large regenerative nodules.", + "output": "Postnecrotic cirrhosis (Liver Cirrhosis)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as a dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.", + "output": "titanium metallicum/titanium (T [Preparations])" + }, + { + "input": "Definition: Pharmacologic Substance described as an agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134;TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40 antibody PF-04518600 selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121927\" active clinical trials using this agent.", + "output": "PF04518600 (Anti-OX40 Monoclonal Antibody)" + }, + { + "input": "Definition: Form family Cryptococcaceae described as mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium.", + "output": "Filobasidiella (Subphylum Basidiomycotina)" + }, + { + "input": "Definition: Findings-Based Question described as a question about how satisfied or dissatisfied an individual is with the way a medication relieves symptoms.", + "output": "How satisfied or dissatisfied are you with the way the medication relieves your symptoms (Findings-Based Question)" + }, + { + "input": "Definition: Conceptual Entity described as immunity from an obligation or duty.", + "output": "Exemption (Conceptual Entity)" + }, + { + "input": "Definition: something described as the newly described syndrome includes severe intellectual deficit with pronounced speech delay, behavioral abnormalities including hyperactivity and inappropriate laughter, short stature and seizures. To date, fifteen patients have been reported. Dysmorphic features include microcephaly, wide and open mouth, a tented upper lip, and prominent incisors. The majority of cases present with stereotypic repetitive behavior, disturbed sleep pattern and a broad-based gait. Skeletal abnormalities include generalized brachydactyly with small hands and feet. The size of the deletions is variable the critical region includes a single gene, MBD5.", + "output": "Monosomy 2q23.1 (Deletion of part of long arm of chromosome 2)" + }, + { + "input": "Definition: IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - How much time did you usually spend on one of those days doing moderate physical activities as part of your work?: hours per day.", + "output": "IPA0305A (Intellectual Product)" + }, + { + "input": "Definition: regulation of morphogenesis of a branching structure described as any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.", + "output": "regulation of prostatic bud formation (regulation of morphogenesis of a branching structure)" + }, + { + "input": "Definition: Intellectual Product described as a document that authorizes a person to operate a motor vehicle on public roads.", + "output": "driver license (Intellectual Product)" + }, + { + "input": "Definition: Pregnancy Complications described as damages to the EMBRYO, MAMMALIAN or the FETUS before BIRTH. Damages can be caused by any factors including biological, chemical, or physical.", + "output": "Prenatal Injury (Pregnancy Complications)" + }, + { + "input": "Definition: Protein, Organized by Location described as protein within the interior of the cell; excludes membrane, mitochondrial, and nuclear proteins.", + "output": "Cytoplasmic Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Cell Component described as a specific pair of GROUP E CHROMOSOMES of the human chromosome classification.", + "output": "Chromosome 16 (Chromosomes, Human, 16-18)" + }, + { + "input": "Definition: Bacterium described as a species of nonpathogenic fluorescent bacteria found in feces, sewage, soil, and water, and which liquefy gelatin.", + "output": "Liquidomonas fluorescens (Bacterium)" + }, + { + "input": "Definition: Finding described as a microscopic finding indicating that a tumor exhibits more than one line of histologic differentiation.", + "output": "Divergent Differentiation (Tissue Differentiation)" + }, + { + "input": "Definition: Intellectual Product described as slight limitation of ordinary activity. Angina occurs on walking or climbing stairs rapidly, walking uphill, walking or climbing stairs after meals, or in cold, in wind, or under emotional stress, or only during the few hours after awakening. Angina occurs on walking more than 2 blocks on the level and climbing more than 1 flight of ordinary stairs at a normal pace and in normal conditions.", + "output": "Angina with moderate exertion (Canadian Cardiovascular Society Grading Scale Class)" + }, + { + "input": "Definition: Bone structure of lumbar vertebra described as the fifth lumbar vertebra counting from the top down.", + "output": "l5 vertebra (BONES OF VERTEBRAL COLUMN)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.", + "output": "tetrapyrrole degradation (cellular nitrogen compound catabolic process)" + }, + { + "input": "Definition: something described as asymptomatic, intervention not indicated", + "output": "Grade 1 Ventricular arrhythmia (Ventricular Arrhythmia, CTCAE 5.0)" + }, + { + "input": "Definition: Transcription Regulation Gene described as this gene plays a role in both signal transduction and transcriptional regulation.", + "output": "YORKIE, DROSOPHILA, HOMOLOG OF (Signaling Pathway Gene)" + }, + { + "input": "Definition: Biomedical or Dental Material described as medicinal product consisting of an intravitreal implant presented in an applicator.", + "output": "Intravitreal Implant in Applicator (Dosage Form and Package Type)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as protein Wnt-2 (360 aa, ~40 kDa) is encoded by the human WNT2 gene. This protein plays a role in frizzled signaling pathways.", + "output": "IRP protein, human (WNT Family Protein)" + }, + { + "input": "Definition: something described as a semiquantitative finding indicating that the amount of immature mononuclear cells in a subject's sample of nucleated cells from bone marrow has decreased by 50 percent or more over the value recorded for a pretreatment sample from that subject.", + "output": "Decrease of Pretreatment Bone Marrow Blast Percentage by at Least 50 Percent (Finding)" + }, + { + "input": "Definition: Untreated Hematopoietic and Lymphoid Cell Neoplasm described as a finding of small lymphocytic lymphoma that has not been treated.", + "output": "Untreated Small Lymphocytic Lymphoma (Untreated Hematopoietic and Lymphoid Cell Neoplasm)" + }, + { + "input": "Definition: Axon Fasciculation described as the collection of motor neuron axons into a bundle of rods, known as a fascicle.", + "output": "fasciculation of motor neuron axon (Cell Function)" + }, + { + "input": "Definition: positive regulation of stress-activated protein kinase signaling cascade described as any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.", + "output": "positive regulation of p38 MAPK signalling (positive regulation of stress-activated protein kinase signaling cascade)" + }, + { + "input": "Definition: something described as partial resection of injured organ/structure indicated", + "output": "Grade 2 Intraoperative ocular injury (Intraoperative Ocular Injury, CTCAE)" + }, + { + "input": "Definition: Colorectal Neuroendocrine Tumor Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.", + "output": "Colorectal Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Primary malignant neoplasm of skin described as a sarcoma of the deep layers of the skin. The tumors are locally aggressive tends to recur but rarely metastatic. It can be classified into variants depending on the cell type tumors are derived from or by its characteristics: Pigmented variant from MELANIN-containing DERMAL DENDRITIC CELLS; Myxoid variant, myxoid STROMAL CELLS; Giant cell variant characterized by GIANT CELLS in the tumors; and Fibrosarcomatous variant chracterized by tumor areas histologically indistinguishable from FIBROSARCOMA.", + "output": "dermatofibrosarcoma (Dermatofibrosarcoma Protuberans)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Malabsorption (Finding)" + }, + { + "input": "Definition: Other nervous and musculoskeletal symptoms described as for cerebral dominance, the presence of right dominance or preference for some functions (eye dominance, foot preference, hand preference), and left dominance or preference for others", + "output": "Crossed laterality (Other nervous and musculoskeletal symptoms)" + }, + { + "input": "Definition: positive regulation of nucleic acid-templated transcription described as any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity.", + "output": "upregulation of RNA replicase activity (positive regulation of transferase activity)" + }, + { + "input": "Definition: Ocular Physiological Phenomena described as the discharge of substances into the TEARS.", + "output": "Elimination, Lacrimal (Drug Elimination Routes)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a group of structurally related scavenger receptors expressed predominately by ENDOTHELIAL CELLS. They-contain repeats of EPIDERMAL GROWTH FACTOR-like cysteine-rich motifs in their extracellular domains.", + "output": "Scavenger Receptors, Class F (scavenger receptor)" + }, + { + "input": "Definition: something described as a question about an individual getting child care or babysitting help for their ill child.", + "output": "Get Child Care or Babysitting Help for Your Ill Child (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVA includes: (Any T, N1, M0); (Any T, N0,1, M1a). N0: No regional lymph node metastasis. N1: Metastasis in anterior (perithymic) lymph nodes. M0: No distant metastasis. M1a: Separate pleural or pericardial nodule(s).", + "output": "Stage IVA Thymic Epithelial Neoplasm AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Recurrent Malignant Neoplasm described as the reemergence of a metastatic malignant neoplasm after a period of remission.", + "output": "Recurrent Metastatic Malignant Neoplasm (Recurrent Malignant Neoplasm)" + }, + { + "input": "Definition: Other immunostimulants in ATC described as a cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP.", + "output": "SIPULEUCEL-T (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or has experienced something and that they are quite concerned.", + "output": "Yes, and I am quite concerned (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: C-SSRS Children's Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Children's Since Last Visit - Description of non-specific active suicidal thoughts.", + "output": "CSS08-Non-Specific Suicid Thought, Descr (Intellectual Product)" + }, + { + "input": "Definition: Central Nervous System described as an abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG) and being identified at multiple locations (foci).", + "output": "Multifocal epileptiform discharges (Central Nervous System)" + }, + { + "input": "Definition: something described as present", + "output": "Grade 1 Glucosuria (Glucosuria, CTCAE)" + }, + { + "input": "Definition: Vaccines, Peptide described as a cancer vaccine containing two HLA-A*0201-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from: vascular endothelial growth factor receptors (VEGFR) 1 and 2. Upon administration, HLA-A*0201-restricted VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing VEGFR 1 and 2 peptides, resulting in tumor cell lysis and decreased tumor growth. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity.", + "output": "HLA-A*0201-Restricted VEGFR1-VEGFR2 Multipeptide Vaccine (Vaccines, Peptide)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a RIP serine-theonine kinase that contains a C-terminal caspase activation and recruitment domain. It can signal by associating with other CARD-signaling adaptor proteins and INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.", + "output": "cardiak (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as human POLD3 wild-type allele is located in the vicinity of 11q14 and is approximately 175 kb in length. This allele, which encodes DNA polymerase delta subunit 3 protein, is involved in the positive regulation of DNA replication. Somatic mutation of the gene may be associated with renal cell carcinoma.", + "output": "POLD3 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Organism Function described as the series of events in which a stimulus from a yeast is received and converted into a molecular signal.", + "output": "detection of yeast (response to yeast)" + }, + { + "input": "Definition: something described as a blood concentration of prostate specific antigen that is greater than 0.1 ng/mL.", + "output": "PSA Level Greater than 0.1 (Finding)" + }, + { + "input": "Definition: something described as terminology related to result values that are considered normal or within normal limits.", + "output": "Within Normal Limits Results (Intellectual Product)" + }, + { + "input": "Definition: something described as an individual educated in the discipline of midwifery, who possesses evidence of certification according to the requirements of ACNM.", + "output": "Certified Midwife (Medical Occupation)" + }, + { + "input": "Definition: Intellectual Product described as software designed to operate digital radiography systems and control/monitor a limited number of the radiographic system functions. This software usually interacts with the x-ray subsystem, detectors, and monitors. It may also perform a variety of algorithms to facilitate the operation and analysis of the data and images obtained during the radiographic procedure. Digital radiographic system software is intended to work only with one or a few models of radiographic systems and related devices, usually supplied by the same manufacturer. This also facilitates the processing and/or sending of data from the digital radiographic system to and from picture archiving and communication systems (PACS) and/or other hospital information systems. The software is not usually available separate from the radiographic system but may be updated (i.e., through the release of modified versions) during the life of the equipment. Dedicated digital radiography system software intended for chest, dental, mammographic, and other radiographic procedures is also available.", + "output": "Software, Digital Radiographic System (Computer software)" + }, + { + "input": "Definition: Finding described as a disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.", + "output": "Guillain-Barre syndrome (Nervous System Disorders, CTCAE)" + }, + { + "input": "Definition: Diagnostic, Therapeutic, and Research Equipment described as equipment designed to remove moisture, either in liquid or vapor state, from devices, films, fabrics, objects, and/or gases using a physical procedure (e.g., heat, centrifugal force, refrigeration, forced air, filtration), and/or natural convection or with the exclusive use of chemical desiccating products. Dedicated dryers are used in healthcare facilities to dry labware, laboratory slides and gels, laundry, small devices and/or utensils, forensic evidence, and x-ray films; they are also used to dry the air in medical air systems.", + "output": "dryer (Diagnostic, Therapeutic, and Research Equipment)" + }, + { + "input": "Definition: something described as the covalent attachment of a UDP-glucose residue to a substrate molecule.", + "output": "UDP-glucosylation (Molecular Function)" + }, + { + "input": "Definition: something described as serologic assay that detects antibodies to Treponema pallidum, the etiologic agent of syphilis. After diluting the patient's serum to remove non-specific antibodies, the serum is mixed on a glass slide with Nichol's strain of Treponema pallidum. An antigen-antibody reaction occurs if the test is positive and the bound antibodies are detected with fluoresceinated antihuman gamma-globulin antibody.", + "output": "FTA-ABS Tests (LABORATORY IMMUNOLOGIC PROCEDURES)" + }, + { + "input": "Definition: Biologic Function described as the process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes.", + "output": "zygosporangium development (Biologic Function)" + }, + { + "input": "Definition: General anatomical term described as a reproductive organ that produces gametes.", + "output": "gonada (Genitourinary system)" + }, + { + "input": "Definition: Indicator described as specifies whether a person has authorized the use and disclosure of their private and/or confidential information.", + "output": "Confidentiality Indicator (Qualitative Concept)" + }, + { + "input": "Definition: Powder for Solution Dosage Form described as solid preparation for veterinary use consisting of one or more powder intended to be dissolved in the animal drinking water.", + "output": "Powder for Use in Drinking Water Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Transcaucasia described as a country in southwestern Asia, east of Turkey and south of Georgia.", + "output": "Armenian SSR (Country)" + }, + { + "input": "Definition: Neurological lesion described as increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.", + "output": "Glaucoma NOS (Optic Disk Disorders)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a mitochondrial fatty acid oxidation disorder characterised by hyperinsulinaemic hypoglycaemia with seizures, and in one case fulminant hepatic failure. Less than 10 cases have been reported to date. The disease can present in infancy or early childhood. It presents with the manifestations of hyperinsulinaemic hypoglycaemia with vomiting, lethargy and seizures. Complications include coma and sudden death. It has responded well to diazoxide. It is caused by a mutation in the HADH gene (4q22-q26) encoding the SCHAD protein that has a dual function both as an enzyme and an inhibitor of glutamate dehydrogenase. The mode of inheritance is autosomal recessive.", + "output": "Hyperinsulinism due to short chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (Hyperinsulinism)" + }, + { + "input": "Definition: Body Location or Region described as subsegment of liver demarcated by intrahepatic distribution of hepatic artery and biliary ducts.", + "output": "Portal triad subsegment (Subsegment of liver)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine.", + "output": "choloylglycine hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as roland Morris Disability Questionnaire (RDQ) I have trouble putting on my socks (or stockings) because of the pain in my back.", + "output": "RDQ0116 (RDQ Questionnaire Question)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.", + "output": "negative regulation of enamel mineralization (negative regulation of odontogenesis of dentin-containing tooth)" + }, + { + "input": "Definition: Rearrangement Detected described as indicates that the expression of a ROS1 fusion has been detected in a sample.", + "output": "c-Ros-1 Fusion Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: Serine/Threonine Protein Kinase Gene described as this gene plays a role in diacylglycerol-dependent signaling.", + "output": "Protein Kinase C, Epsilon Gene (Serine/Threonine Protein Kinase Gene)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as in traditional Chinese medicine, a type of heat therapy in which an herb is burned on or above the skin to warm and stimulate an acupuncture point or affected area.", + "output": "moxibustion (Acupuncture and allied techniques)" + }, + { + "input": "Definition: Occupation or Discipline described as a branch of knowledge that records and explains past events regarding a branch of science (ie biology, medicine, anthropology, or sociology) that deals with living organisms and life processes.", + "output": "history of life science (Occupation or Discipline)" + }, + { + "input": "Definition: Debaryomyces described as a species of commensal yeast in the family Trichocomaca that are found in cheese, dairy products and the environment. It is rarely recovered from clinical specimens, usually associated with skin. C. famata is negative for fermentation on lactose and galactose.", + "output": "Pichia hansenii (Candida)" + }, + { + "input": "Definition: Postnatal anatomical structure described as postnatal anatomical structure, each instance of which has as it direct parts a heterogeneous collection of some instances of two or more subclasses of anatomcial structure, which are spatially related to one another; the collections as a whole does not satisfy the definition of any other subclass of anatomical structure. Eaxmples: root of lung, back, anatomical snuffbox, motor unit, juxtaglomerular complex.", + "output": "Anatomical cluster (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Finding described as hypopharyngeal cancer with tumor limited to one subsite of the hypopharynx and with tumor size 2 centimeters or less in greatest dimension.", + "output": "Hypopharyngeal Cancer pT1 TNM Finding v6 (Finding)" + }, + { + "input": "Definition: something described as a skull punch is a device used to punch holes through a patient's skull to allow fixation of cranioplasty plates or bone flaps by wire or other means.", + "output": "Skull punch (Surgical punch)" + }, + { + "input": "Definition: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Primary Tumor TNM Finding v8 described as uterine corpus leiomyosarcoma or endometrial stromal sarcoma with tumor infiltrating abdominal tissues.", + "output": "Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pT3 TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Clinical Attribute described as functions related to the general level of tolerance of physical exercise or stamina.", + "output": "General physical endurance (Clinical Attribute)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine metanephrines, both normetanephrine and metanephrine, products from the metabolization of the hormones norepinephrine and epinephrine, respectively. Increased levels of urinary metanephrines are found in patients with catecholamine-secreting tumors.", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Hormone Metabolite, Metanephrine (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Hormone Metabolite)" + }, + { + "input": "Definition: Medical Device described as surgical instrument motors and accessories are AC-powered, battery-powered, or air-powered devices intended for use during surgical procedures to provide power to operate various accessories or attachments to cut hard tissue or bone and soft tissue. Accessories or attachments may include a bur, chisel (osteotome), dermabrasion brush, dermatome, drill bit, hammerhead, pin driver, and saw blade.", + "output": "BIT, SURGICAL (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as a score of -3 on a comparative scale that ranges from 3+: Very much better to -3: Very much worse.", + "output": "Comparative Score -3 (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the EF-hand domain containing 1 (EFHC1) gene, located at chromosome 6p12.3, which encodes EF-hand domain-containing protein 1. Genetic variants at this locus have been associated with juvenile myoclonic epilepsy and juvenile absence epilepsy.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, EFHC1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: something described as this gene is involved in mineralocorticoid metabolism.", + "output": "CYP11B2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Radiating Chest Pain Along Sternal Border described as the location of the radiating chest pain is along the left upper sternal border.", + "output": "Radiating Chest Pain Along Left Upper Sternal Border (Radiating Chest Pain Along Sternal Border)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.", + "output": "nucleoside diphosphate metabolism (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as peripheral myelin protein 22 (160 aa, ~18 kDa) is encoded by the human PMP22 gene. This protein is involved in the determination of the structure and deposition of myelin.", + "output": "Growth Arrest-Specific Protein 3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Peritonitis and retroperitoneal infections described as inflammation of the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen). Peritonitis can result from infection, injury, or certain diseases. Symptoms may include swelling of the abdomen, severe pain, and weight loss.", + "output": "PERITONITIS (Disorder of soft tissue of body cavity)" + }, + { + "input": "Definition: something described as a clot detection method that uses a mechanical means (electromagnetic mechanical or electromechanical) to detect the presence of or quantify the formation of a thrombus in a specimen.", + "output": "MECHANICAL CLOT DETECTION (Clot Detection)" + }, + { + "input": "Definition: Duplication of the middle phalanx of the 3rd toe described as complete duplication of middle phalanx of third toe.", + "output": "Complete duplication of the middle bone of the 3rd toe (Duplication of the middle phalanx of the 3rd toe)" + }, + { + "input": "Definition: Pulmonary function tests described as the elasticity of the pulmonary walls.", + "output": "PULMCOMP (Finding)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial.", + "output": "beta-carotene oxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)" + }, + { + "input": "Definition: Injection and Infusion described as delivery of substances through VENIPUNCTURE into the VEINS.", + "output": "Administrations, Intravenous (Drug Administration Routes)" + }, + { + "input": "Definition: Ranked categories described as any number of entities (members) considered as a unit.", + "output": "Panel (Ranked categories)" + }, + { + "input": "Definition: orthopedic disorders described as partial or incomplete displacement of an articulation.", + "output": "subluxations (Injury or Poisoning)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the CDX2 antigen in a biological specimen.", + "output": "CDK-2 Antigen Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - Since returning: I play an important role in my family.", + "output": "DRRI1-P: Play Important Role in Family (Intellectual Product)" + }, + { + "input": "Definition: HLA-DRB3 & HLA-DRB4 & HLA DRB5 described as a subtype of HLA-DRB beta chains that includes over 50 allelic variants. The HLA-DRB3 beta-chain subtype is associated with HLA-DR52 serological subtype.", + "output": "HLA-DRB3 Antigen (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a nonsteroidal anti-inflammatory drug (NSAID) belonging to the salicylate family. Choline magnesium trisalicylate inhibits inflammation-related prostaglandin synthesis. This agent's analgesic effect is mediated through peripheral and central pathways, resulting in a decrease in pain perception; its antipyretic effect is mediated via the hypothalamic heat regulation center.", + "output": "CHOLINE MAGNESIUM TRISALICYLATE (magnesium salicylate)" + }, + { + "input": "Definition: something described as human IGLC1 wild-type allele is located in the vicinity of 22q11.22 and is approximately 0.5 kb in length. This allele, which encodes Ig lambda-1 chain C regions, is involved in innate immunity.", + "output": "Immunoglobulin Lambda Constant 1 (Mcg Marker) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Respiratory tract evaluation described as a procedure on the respiratory tract that observes pulmonary function", + "output": "Test, Respiratory Function (Measurement)" + }, + { + "input": "Definition: Population Group described as a group of individuals who share a common exposure, experience or characteristic or a group of individuals followed-up or traced over time in a cohort study. [AMA Manual of Style] See also cohort study.", + "output": "cohorting (Population Group)" + }, + { + "input": "Definition: Carbapenems described as beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.", + "output": "Antibiotics, Thienamycin (Antibiotic)" + }, + { + "input": "Definition: something described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the trial summary domain.", + "output": "Trial Summary Supplemental Qualifiers Dataset (Intellectual Product)" + }, + { + "input": "Definition: Intermediate Filament Proteins described as keratin, type II cytoskeletal 7 (469 aa, ~51 kDa) is encoded by the human KRT7 gene. This protein plays a role in DNA replication and cytoskeleton modeling.", + "output": "Type-II Keratin Kb7 (Intermediate Filament Proteins)" + }, + { + "input": "Definition: organic hydroxy compound metabolic process described as the chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities.", + "output": "flavonol metabolic process (organic hydroxy compound metabolic process)" + }, + { + "input": "Definition: Extended Release Patch Dosage Form described as a patch that composed of active and/or inert ingredient(s) whose release is controlled by electronic impulses that release ingredients at a controlled, prolonged rate so as to reduce dosing frequency.", + "output": "Electrically Controlled Extended Release Patch Dosage Form (Extended Release Patch Dosage Form)" + }, + { + "input": "Definition: ERT Functional Test Question described as emotion Recognition - Number of happiness stimuli responded to as anger.", + "output": "EMO110A (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as the aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.", + "output": "mitochondrial respiratory chain complex assembly (Molecular Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a hemipelvectomy with the resection confined to ilium.", + "output": "Hemipelvectomy Type I (Hemipelvectomy)" + }, + { + "input": "Definition: something described as a question about how many visits an individual has had with other doctors at a specific medical office.", + "output": "Number of Visits to Other Doctors in This Office (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Molecular Function described as the appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "M-CSF production (cytokine production)" + }, + { + "input": "Definition: Nonproliferative diabetic retinopathy described as microaneurysms only", + "output": "Mild nonproliferative diabetic retinopathy (Diabetic Retinopathy)" + }, + { + "input": "Definition: Disorder of the genitourinary system described as a non-neoplastic disorder that affects the genitourinary system.", + "output": "Non-Neoplastic Genitourinary System Disorder (Disorder of the genitourinary system)" + }, + { + "input": "Definition: intramolecular oxidoreductase activity, interconverting aldoses and ketoses described as catalysis of the reaction: L-rhamnose = L-rhamnulose.", + "output": "L-rhamnose aldose-ketose-isomerase activity (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)" + }, + { + "input": "Definition: Gene or Genome described as human PLK4 wild-type allele is located in the vicinity of 4q28 and is approximately 18 kb in length. This allele, which encodes serine/threonine-protein kinase PLK4 protein, is involved in centriole duplication.", + "output": "PLK4 wt Allele (PLK4 gene)" + }, + { + "input": "Definition: Simple organic compound described as synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.", + "output": "Hydroxymethoxyphenylglycol (Biologically Active Substance)" + }, + { + "input": "Definition: something described as chronic myelomonocytic leukemia not growing; responding to treatment.", + "output": "Chronic myelomonocytic leukaemia (MYELODYSPLASTIC SYNDROME)" + }, + { + "input": "Definition: something described as the directed movement of nitrate into a cell or organelle.", + "output": "nitrate influx (nitrate transport)" + }, + { + "input": "Definition: Deformity of lower limb described as an outward slant of the thigh in which the knees are wide apart and the ankles close together. Genu varum can develop due to skeletal and joint dysplasia (e.g., OSTEOARTHRITIS; Blount's disease); and malnutrition (e.g., RICKETS; FLUORIDE POISONING).", + "output": "Lower limb bowing (Deformity of lower limb)" + }, + { + "input": "Definition: Suppository described as a suppository intended for administration to children.", + "output": "Pediatric Suppository Dose Form (Suppository)" + }, + { + "input": "Definition: Antineoplastic Biological Agent described as a fusion protein consisting of an anti-single-chain variable fragment (scFv) peptide sequence targeting the extracellular domain of human CD133 (prominin-1) (anti-CD133scFV) and a deimmunized truncated form of Pseudomonas exotoxin A (38-kDa derivative of PE; PE38) where the five C-terminal amino acid residues have been replaced with the endoplasmic reticulum (ER) retention signal, KDEL, with potential antineoplastic activity. Upon administration of the anti-CD133-PE38-KDEL fusion protein, the anti-CD133 scFV moiety targets and binds to CD133, which is expressed on a variety of tumor cells. Upon internalization of the receptor-fusion protein complex, the KDEL sequence targets the fusion protein to the ER, where the PE38 exotoxin portion then inhibits protein synthesis, which results in a reduction of proliferation of CD133-expressing tumor cells. CD133, a glycoprotein expressed by a variety of cancers and especially by cancer stem cells (CSCs), plays a key role in tumor initiation, proliferation and progression. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C131828\" active clinical trials using this agent.", + "output": "CD133KDEL (Antineoplastic Biological Agent)" + }, + { + "input": "Definition: something described as amount paid to purchase individual volumes or set from a bookseller.", + "output": "Books--Prices (Quantitative Concept)" + }, + { + "input": "Definition: Supplemental Qualifiers Tabulation Dataset described as a dataset used to represent non-standard variables and their association to parent records in the Concomitant/Prior Medications domain.", + "output": "Supplemental Qualifiers for Concomitant/Prior Medications (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: Regimen Used to Treat Central Nervous System Neoplasm described as a chemotherapy regimen consisting of intra-cerebrospinal fluid (CSF) interferon (IFN) alfa-2b that may be used in the treatment of leptomeningeal metastases.", + "output": "Intra-cerebrospinal Fluid Interferon alfa-2b Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: phloem transport described as the process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues.", + "output": "phloem unloading (phloem transport)" + }, + { + "input": "Definition: something described as suture needles with a tip that is not as sharp (i.e., more blunt) as the tip of a conventional tapered suture needle; they can still penetrate tissues for suturing, but the blunt needle does not easily penetrate tough tissues, such as the skin. These needles are typically used for suturing kidney and liver tissues; they are also used in general surgery as a substitute for tapered-point needles to lessen the possibility that accidental contact with the needle tip will result in a needlestick injury. The use of blunt suture needles for some procedures requires changes in the surgical technique for suturing; they are not appropriate for skin-closure applications.", + "output": "Needles, Suture, Surgical, Blunt Point (Needles, Suture, Surgical)" + }, + { + "input": "Definition: Gastric Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v7 described as gastric neuroendocrine tumor without evidence of distant metastasis.", + "output": "Gastric Neuroendocrine Tumor cM0 TNM Finding v7 (Gastric Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: mesonephric nephron tubule morphogenesis described as the process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule.", + "output": "mesonephric proximal tubule morphogenesis (proximal tubule morphogenesis)" + }, + { + "input": "Definition: Acanthosis described as a type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis.", + "output": "Sawtooth acanthosis (Acanthosis)" + }, + { + "input": "Definition: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances described as catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA.", + "output": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a question about an individual's ability to walk up stairs.", + "output": "climb stairs (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Finding described as a subjective response indicating that something is definitely true.", + "output": "Definitely true (How True)" + }, + { + "input": "Definition: Chronic nephritic syndrome described as characterized histologically by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane; clinically similar to chronic glomerulonephritis, occasionally with transient nephrotic syndrome.", + "output": "GLOMERULOPATHY, MEMBRANOUS (Autoimmune Diseases)" + }, + { + "input": "Definition: Molecular Function described as the trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine.", + "output": "N-terminal peptidyl-alanine trimethylation (Molecular Function)" + }, + { + "input": "Definition: Manufactured Object described as a set of electrical conductors designed to route data from multiple locations in a computer.", + "output": "Bus (Manufactured Object)" + }, + { + "input": "Definition: something described as a blood concentration of prostate specific antigen less than 10 ng/mL.", + "output": "PSA Level Less than Ten (PSA Level Finding)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a solution intended for administration either on the outer ear or into the auditory canal.", + "output": "Otic Solution (Solution Dosage Form)" + }, + { + "input": "Definition: Cytochrome P450 Family 26 described as a cytochrome P450 enzyme that resides in the ENDOPLASMIC RETICULUM. It catalyzes the conversion of trans-RETINOIC ACID to 4-hydroxyretinoic acid.", + "output": "RA-4-Hydroxylase (Cytochrome P450 Family 26)" + }, + { + "input": "Definition: something described as a sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.", + "output": "Tonelessness Syndromes (Neuromuscular Diseases)" + }, + { + "input": "Definition: something described as uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.", + "output": "Class 1b Uveal Melanoma (Class 1 Uveal Melanoma)" + }, + { + "input": "Definition: P4HA2 gene described as human P4HA2 wild-type allele is located in the vicinity of 5q31 and is approximately 103 kb in length. This allele, which encodes prolyl 4-hydroxylase subunit alpha-2 protein, plays a role in procollagen processing.", + "output": "Collagen Prolyl 4-Hydroxylase Alpha(II)Gene (P4HA2 gene)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as multisubunit protein complexes of adaptor proteins.", + "output": "Vesicular Transport Adaptor Protein Complex (Biologically Active Substance)" + }, + { + "input": "Definition: New client home-visit with ICD diagnosis described as evaluating and managing a new client in a simple, 10-minute home-visit. This code may be used by providers of services who are able to diagnose.", + "output": "new hmvst 10min (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: regulation of biological quality described as any process that modulates the rate or extent of heat dissipation.", + "output": "regulation of heat dissipation (regulation of multicellular organismal process)" + }, + { + "input": "Definition: something described as a question about how often a person thought about resolving problems in their living situation.", + "output": "Resolving problems in your living situation (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2).", + "output": "L-lysine carboxy-lyase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the determination of the amount of sertraline present in a sample.", + "output": "SERTRAL (Laboratory Procedure)" + }, + { + "input": "Definition: St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) These are more questions about your cough and shortness of breath these days: Coughing hurts.", + "output": "SGRQ0119 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of five midline nuclei of the thalamus as defined in Olszewski-1952. The other nuclei in the group are the Nucleus centralis latocellularis, the Nucleus centralis inferior thalami, the Nucleus centralis superior thalami, and the Nucleus centralis intermedialis. Together they constitute the central medial nucleus and the rhomboidal nucleus.", + "output": "Nucleus centralis densocellularis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as clinical manifestations of cardiac syncope, ventricular tachycardia, ventricular fibrillation, or sudden death in conjunction with a genetic mutation associated with Brugada Syndrome and/or a Brugada pattern ECG (spontaneous or provoked).", + "output": "brugada syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus.", + "output": "response to chromate (Cell Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the regulation of the inflammatory response.", + "output": "phospholipase A2 group IVA (Gene or Genome)" + }, + { + "input": "Definition: Organism Function described as behavior that is dependent upon the sensation of a mechanical stimulus.", + "output": "mechanosensory behaviour (Behavior)" + }, + { + "input": "Definition: PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) During the last week, has it been easy or hard for your child to: Bicycle or tricycle?", + "output": "PODCI1-Bicycle or Tricycle (PODCI Pediatric Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Surgery and Rehabilitation described as use of instruments for visual examination of interior structures of the body; there are rigid endoscopes and flexible fiberoptic endoscopes for various types of viewing for disease diagnosis and treatment; involves passing an optical instrument along either natural body pathways such as the digestive tract, or through keyhole incisions to examine the interior parts of the body; with advances in imaging, endoscopes, and miniaturization of endosurgical equipment, surgery can be performed during endoscopy.", + "output": "endoscopic procedure (Physical Examination)" + }, + { + "input": "Definition: Congenital sensorineural hearing loss described as a rare demyelinating hereditary motor and sensory neuropathy characterized by early-onset, slowly progressive, distal muscular weakness and atrophy with no sensory impairment, congenital sensorineural deafness and mild intellectual disability (with absence of normal speech development). The absence of large myelinated fibers on sural nerve biopsy is equally characteristic of the disease.", + "output": "Charcot-Marie-Tooth disease, deafness, intellectual disability syndrome (Intellectual Disability)" + }, + { + "input": "Definition: something described as a data type comprised of a physical quantity divided by another physical quantity.", + "output": "RTO (Intellectual Product)" + }, + { + "input": "Definition: Situation with explicit context described as information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins. []", + "output": "Health Histories, Family (Finding)" + }, + { + "input": "Definition: Nutritional Physiological Phenomena described as the process or act of converting food into chemical substances that can be absorbed and assimilated.", + "output": "digestions (Gastrointestinal Process)" + }, + { + "input": "Definition: Anatomical Abnormality described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 5th finger.", + "output": "Speckled calcifications in end part of the middle bone of the pinky finger (Abnormality of the epiphysis of the middle phalanx of the 5th finger)" + }, + { + "input": "Definition: Reproductive hormone analyses described as a measurement of the estrone hormone in a biological specimen.", + "output": "Measurement of estrone (17-Ketosteroids measurement)" + }, + { + "input": "Definition: something described as tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.", + "output": "adenomatosis polyposis coli (Genes)" + }, + { + "input": "Definition: Mammal described as dogs that are trained to perform practical tasks, as opposed to PETS or companion dogs.", + "output": "Dog, Working (Mammal)" + }, + { + "input": "Definition: Finding described as absence of information e.g. labeling, instruction for use.", + "output": "Missing Information (Device Markings/Labeling Problem)" + }, + { + "input": "Definition: Medical Device described as amplatz right modified", + "output": "AR mod (Medical Device)" + }, + { + "input": "Definition: Cell Function described as the process by which a phagocyte (a type of white blood cell) surrounds and destroys foreign substances (such as bacteria) and removes dead cells.", + "output": "phagocytosis (IMMUNOLOGIC MECHANISMS AND PHENOMENA)" + }, + { + "input": "Definition: Finding described as a response that concurrent chemotherapy was the curative therapy.", + "output": "Concurrent Chemotherapy was Curative Therapy (CPTAC Responses)" + }, + { + "input": "Definition: something described as bacteria culture media that include a solidifying agent derived from red seaweeds (i.e., agar) and that are available in ready-to-use bottles. These media may need supplementation with other reagents before use.", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Bottle, Agar (Medical Device)" + }, + { + "input": "Definition: Medicine described as the branch of medicine that involves the laboratory growth of functional tissues and organs and their use to regenerate or replace tissues and organs in the body that are damaged by diseases or cannot be healed. Examples include the transplantation of in vitro developed tissues, cell therapies, and stimulation of regeneration by biological substances.", + "output": "Regenerative Medicines (Medical Specialities)" + }, + { + "input": "Definition: something described as any elsewhere undefined general laboratory test, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "Undefined general laboratory test narrative required (Laboratory Procedure)" + }, + { + "input": "Definition: Neoplasm of lower respiratory tract described as stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b). M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion. M1b: Distant metastasis.", + "output": "Large cell lung cancer stage IV (Metastatic non-small cell lung cancer)" + }, + { + "input": "Definition: Digestive system hereditary disorder described as a rare congenital isolated hyperinsulinism disorder with characteristics of neonatal presentation of severe refractory hypoglycemia in the first two days of life with limited response to medical management sometimes requiring pancreatic resection. Newborns are often large for gestational age with mild to moderate hepatomegaly and diffuse form of hyperinsulinism due to Kir6.2 deficiency. Persistent hypoglycemia, hyperglycemia and type 1 diabetes mellitus may develop later in life. Life-threatening hypoglycemic coma or status epilepticus have also been associated. Caused by mutation in the gene encoding the Kir6.2 subunit of the inwardly rectifying potassium channel (KCNJ11).", + "output": "Autosomal recessive hyperinsulinemic hypoglycemia due to Kir6.2 deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: something described as terminology codelist used with Trial Summary Parameter within the Clinical Data Interchange Standards Consortium Study Data Tabulation Model.", + "output": "CDISC SDTM Trial Summary Parameter Short Name Terminology (Intellectual Product)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as inventory of Depressive Symptomatology Self-Report Version test code.", + "output": "CDISC Questionnaire IDS-SR Test Code Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as moderate; persistent; psychosocial sequelae", + "output": "Grade 2 Flatulence (Finding)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum.", + "output": "response to molybdenum starvation (response to starvation)" + }, + { + "input": "Definition: Anatomical Abnormality described as an anatomic abnormality of the thyroid gland.", + "output": "Thyroid malformation (Congenital Abnormality)" + }, + { + "input": "Definition: Caring for household objects described as repairing and taking care of assistive devices, such as prostheses, orthoses and specialized tools and aids for housekeeping and personal care; maintaining and repairing aids for personal mobility such as canes, walkers, wheelchairs and scooters; and maintaining communication and recreational aids.", + "output": "Maintaining assistive devices (Caring for household objects)" + }, + { + "input": "Definition: Finding described as suspected seizures with life-threatening consequences (e.g. need for ventilation); suspected status epilepticus* despite multiple anti-seizure drugs. Note: *>30min of convulsions within any 60-minute period.", + "output": "Grade 4 Neonatal Convulsion, Adverse Event (Finding)" + }, + { + "input": "Definition: Stage I Testicular Cancer AJCC v6 and v7 described as stage IS includes: Any pT/TX, N0, M0, S1-3. pTX: Primary tumor cannot be assessed. N0: No regional lymph node metastasis. M0: No distant metastasis. S1: LDH less than 1.5 x N (N indicates the upper limit of normal for the LDH assay) and hCG less than 5,000 and AFP less than 1,000. S2: LDH 1.5-10 x N or hCG 5,000-50,000 or AFP 1,000-10,000. S3: LDH more than 10 x N or hCG more than 50,000 or AFP more than 10,000. (AJCC 6th and 7th eds.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6363\" active clinical trials using this agent.", + "output": "Stage IS Cancer of Testis (Stage I Testicular Cancer AJCC v6 and v7)" + }, + { + "input": "Definition: Count described as the number of sequencing reaction results that were pooled to assemble a sequence for a genomic region of interest.", + "output": "Read Count (Count)" + }, + { + "input": "Definition: Food described as food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).", + "output": "genetically modified foods (Food)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate.", + "output": "nucleobase-containing compound kinase activity (Molecular Function)" + }, + { + "input": "Definition: Measurement finding below reference range described as an abnormal reduction below the normal number of red blood cells per volume in the circulation. []", + "output": "Red blood cell count decreased (Abnormality of red blood cells)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Streptococcus pneumoniae serotype 9V IgG antibody in a biological specimen.", + "output": "Streptococcus pneumoniae Serotype 9V IgG Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: something described as compunds that bind to and activate GUANYLYL CYCLASE-C RECEPTORS.", + "output": "Guanylate Cyclase C Agonists (Gastrointestinal Agents)" + }, + { + "input": "Definition: Stage IV Uterine Corpus Cancer described as stage IVA includes: T4, any N, M0. T4: tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: no distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6309\" active clinical trials using this agent.", + "output": "stage IVA endometrial carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Regulatory Protein described as endosialin (757 aa, ~81 kDa) is encoded by the human CD248 gene. This protein may play a role in angiogenesis.", + "output": "CD248 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as zi cao gen", + "output": "lithospermum/zi cao gen (Plant)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual has or had trouble taking a long walk.", + "output": "Do you have any trouble taking a long walk (Intellectual Product)" + }, + { + "input": "Definition: Conceptual Entity described as a property indicating that a food component must be taken into the body preformed and in sufficient quantity to meet the body's needs for growth, reproduction and/or maintenance of health.", + "output": "Nutrient (Conceptual Entity)" + }, + { + "input": "Definition: Introduction procedure described as transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.", + "output": "Transplant Procedure (Therapeutic procedures NEC)" + }, + { + "input": "Definition: Pharmacologic Substance described as a substance that is being studied as a treatment for cancer. It belongs to a family of drugs called antiestrogens.", + "output": "Pipendoxifene (Organic Chemical)" + }, + { + "input": "Definition: Immunologic Factor described as a family of CC-motif cytokines that are produced by macrophages in response to endotoxin exposure. This family has two members C-C motif chemokine 3 and C-C motif chemokine 4. These chemokines promote the inflammatory response through the activation of human granulocytes and induction of the synthesis and release of other pro-inflammatory cytokines.", + "output": "mip-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a chromosome band present on 12p", + "output": "12p13.1-p12.3 (Chromosome band)" + }, + { + "input": "Definition: Pulmonary veins described as anterior segmental vein, each instance of which is vein draining the apicoposterior segment of the superior lobe of some left lung and emptying into some left superior pulmonary vein.", + "output": "Structure of apicoposterior branch of superior left pulmonary vein (Tributary of superior left pulmonary vein)" + }, + { + "input": "Definition: Amino Acid Sequence described as typically found in proteins involved in signaling pathways, the SH3-Binding Motif is a peptide sequence that mediates regulated high-affinity physical interaction (binding) with the SH3 (SRC Homology 3) domain in target protein partners. The SH3-binding motif often share proline-rich stretches containing a common PXXP motif.", + "output": "SH3-Binding Motif (Amino Acid Sequence)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as instructing and/or training a client to properly apply, care for and use an artificial body part. Service is billed in 15-minute increments.", + "output": "Prosthetic movement training individual each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as devices that are affixed to a patient's skull to allow precise localization of an area within the brain targeted for a neurosurgical or radiosurgical procedure. These units typically consist of a head ring assembly with fixation screws or pins, an arc system for setting target coordinates and localizer frames and adapters for CT, MRI and other imaging systems.", + "output": "Frames, Stereotactic (Stereotactic Systems)" + }, + { + "input": "Definition: something described as a cationic lipid DNA complex (CLDC) consisting of DOTIM/cholesterol liposomes and plasmid DNA, containing immunostimulatory CpG and non-CpG motifs, with potential immunostimulating and antineoplastic activities. Upon systemic administration, TLR-directed cationic lipid-DNA complex JVRS-100 enters dendritic cells (DCs) and macrophages; immunostimulatory DNA binds to and activates Toll-like receptors (TLRs), which may result in the generation of anti-tumor natural killer (NK) cell and T-cell responses by the innate immune system. In addition, as a vaccine adjuvant, this agent may induce a strong cytotoxic T-lymphocyte (CTL) response to co-administered antigen. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82353\" active clinical trials using this agent.", + "output": "TLR-Directed Cationic Lipid-DNA Complex JVRS-100 (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Molecular Function described as the bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine.", + "output": "peptidyl-phenylalanine bromination to L-3'-bromophenylalanine (Molecular Function)" + }, + { + "input": "Definition: Public Relations described as interactions between hospital staff or administrators and patients. Includes guest relations programs designed to improve the image of the hospital and attract patients.", + "output": "HOSP PATIENT RELAT (Health Care Activity)" + }, + { + "input": "Definition: Temporal Concept described as the duration of pregnancy from conception to childbirth.", + "output": "Pregnancy Time Period (Period)" + }, + { + "input": "Definition: something described as branch of psychology that deals with paranormal behavior and events such as telepathy, precognition, and clairvoyance, which are not explicable by present day \"natural laws\".", + "output": "parapsychology (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Risk Evaluation and Mitigation Strategies Requirement described as the dispenser must dispense only a limited days supply of the drug.", + "output": "Dispense limited days' supply (Health Care Activity)" + }, + { + "input": "Definition: Qualitative Concept described as characterized by minimal protrusion of the mandible or minimal prognathism.", + "output": "Orthognathous (Qualitative Concept)" + }, + { + "input": "Definition: Laboratory Procedure described as analyzing a client/patient's blood, hair, urine and/or other sample to assess his or her electrolyte levels and/or evaluate acid-base balance. Service is billed per test.", + "output": "electrolyte panl ea.tst (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.", + "output": "Reduced factor VII activity (Finding)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 34 of the coding sequence of the NRAS gene where guanine has been mutated to cytosine.", + "output": "N-ras c.34G>C (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: plant-type cell wall organization described as the aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall.", + "output": "plant-type cell wall assembly (Cell Function)" + }, + { + "input": "Definition: Functional Concept described as specifies whether different lines in k-space are collected for a single frame. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "MRImagingAcquisitionProtocolElement.multipleSpinEchoIndicator (Functional Concept)" + }, + { + "input": "Definition: Neoplastic Process described as a morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present.", + "output": "Pleomorphic Hepatocellular Cancer (Liver carcinoma)" + }, + { + "input": "Definition: Cystatins described as a group of closely-related cystatins found in SALIVA.", + "output": "Cystatins, Salivary (Biologically Active Substance)" + }, + { + "input": "Definition: Extended Release Dosage Form described as a solid, semi-solid, solution or suspension composed of active and/or inert ingredient(s) covered with or contained within a polymeric matrix such that dissolution is determined by the solubility rate of the given polymer. It is designed to release ingredients at a controlled, prolonged rate so as to reduce dosing frequency.", + "output": "Dissolution Controlled Extended Release (Biomedical or Dental Material)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as modified Fatigue Impact Scale (MFIS) (1997 by the National Multiple Sclerosis Society. All rights reserved).", + "output": "MFIS (Intellectual Product)" + }, + { + "input": "Definition: phosphate-containing compound metabolic process described as the chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.", + "output": "parathion metabolic process (organophosphate metabolic process)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Multiple Sclerosis - General Contentment: I am frustrated by my condition.", + "output": "FAMS0126 (FAMS Questionnaire Question)" + }, + { + "input": "Definition: Finding described as an increased amount of subcutaneous fat tissue in the face.", + "output": "Increased amount of facial adipose tissue (Abnormality of facial adipose tissue)" + }, + { + "input": "Definition: PIK3CA NP 006209.2:p.H1047X described as a change in the amino acid residue at position 1047 in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein where histidine has been replaced by arginine.", + "output": "Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide H1047R (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: embryonic morphogenesis described as the spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.", + "output": "germ-band retraction (embryonic morphogenesis)" + }, + { + "input": "Definition: regulation of cell adhesion mediated by integrin described as any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin.", + "output": "regulation of cell-cell adhesion mediated by integrin complex (regulation of cell adhesion mediated by integrin)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses in tissue preparations to determine the presence of a cellular regulatory protein that binds progesterone hormones (i.e., cytoplasmic progesterone receptors). These receptors are especially found in progesterone-sensitive tissues (e.g., breast, uterus, pituitary gland). The assays are usually performed in surgically removed samples; determination of the level of progesterone receptors is used in the prognosis of the response to endocrine therapy (i.e., it is a marker) in diseases such as breast cancer.", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Receptor Assay, Progesterone (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Receptor Assay)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Colorectal Version 4 - Physical Well-Being: I am forced to spend time in bed.", + "output": "FAC00807 (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+).", + "output": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Dietary Sugars described as sucrose present in the diet. It is added to food and drinks as a sweetener.", + "output": "Table Sugars (Nutritive Sweeteners)" + }, + { + "input": "Definition: something described as an indication as to whether the XML copy of the EudraCT application requires secure E-mail delivery.", + "output": "Requires Secure Email Delivery of XML Indicator (Indicator)" + }, + { + "input": "Definition: Cardiovascular neoplasms malignant and unspecified described as a malignant neoplasm originating from vascular pericytes (cells in the periphery of vessels).", + "output": "Malignant Hemangiopericytoma (Primary malignant neoplasm of blood vessel)" + }, + { + "input": "Definition: Finding described as a subjective score of 0 on a visual analogue scale that ranges from 0: No Pain to 10: Excruciating.", + "output": "0 = No Pain (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual's office staff made time for their concerns.", + "output": "Made time for your concerns (Intellectual Product)" + }, + { + "input": "Definition: Eye described as a small break in the retina.", + "output": "retinal hole (Retinal Perforations)" + }, + { + "input": "Definition: something described as clinical chemistry reagents intended to perform semiquantitative chemical analysis of body fluids (typically urine) to determine albumin levels greater than normal, but less that the levels than can be detected in routine screening tests. Urinary albumin excretion is a marker of microvascular disease, and it precedes and is highly predictive of diabetic nephropathy and end-stage renal disease.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Protein, Albumin, Microalbuminaria (Medical Device)" + }, + { + "input": "Definition: FACT-LYM Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Lymphoma Version 4 - Social/Family Well-Being: I get emotional support from my family.", + "output": "FACT-LYM Version 4 - Get Emotional Support From Family (Intellectual Product)" + }, + { + "input": "Definition: Welts described as a skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP.", + "output": "Darier's sign (Sign or Symptom)" + }, + { + "input": "Definition: Medical Device described as an endoscope and accessories is a device used to provide access, illumination, and allow observation or manipulation of body cavities, hollow organs, and canals. The device consists of various rigid or flexible instruments that are inserted into body spaces and may include an optical system for conveying an image to the user's eye and their accessories may assist in gaining access or increase the versatility and augment the capabilities of the devices. Examples of devices that are within this generic type of device include cleaning accessories for endoscopes, photographic accessories for endoscopes, nonpowered anoscopes, binolcular attachments for endoscopes, pocket battery boxes, flexible or rigid choledochoscopes, colonoscopes, diagnostic cystoscopes, cystourethroscopes, enteroscopes, esophagogastroduodenoscopes, rigid esophagoscopes, fiberoptic illuminators for endoscopes, incandescent endoscope lamps, biliary pancreatoscopes, proctoscopes, resectoscopes, nephroscopes, sigmoidoscopes, ureteroscopes, urethroscopes, endomagnetic retrievers, cytology brushes for endoscopes, and lubricating jelly for transurethral surgical instruments. This section does not apply to endoscopes that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.", + "output": "Endoscope Cleaning Brushes (Medical Device)" + }, + { + "input": "Definition: something described as bone Resorption Inhibition involves interference with, or restraint of, absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.", + "output": "Bone Resorption Inhibition (Musculoskeletal Process)" + }, + { + "input": "Definition: Quantitative Concept described as the area under the curve of a plot that graphs a discrete distribution of data calculated from a set of concentration-time data.", + "output": "Area Under First Moment Curve (Quantitative Concept)" + }, + { + "input": "Definition: Gas analyzer described as laboratory monitors designed for continuous measuring and display of the carbon dioxide concentration in a closed or semi-closed environment, usually inside of a laboratory device (e.g. incubator, hood). These monitors typically consist of a central unit including electronic circuitry and a digital display, and carbon dioxide sensors located in the interior of the laboratory device.", + "output": "Monitors, Laboratory, Carbon Dioxide (Laboratory instruments and equipment)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).", + "output": "Ala-tRNA synthetase activity (Genetic Function)" + }, + { + "input": "Definition: Finding described as a genetic finding indicating an excess of DNA methylation in the promoter region of the RASSF1 gene.", + "output": "123F2 Gene Promoter Hypermethylation (Finding)" + }, + { + "input": "Definition: ANTINEOPLASTIC RADIOPHARMACEUTICALS described as a radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.", + "output": "90Y-DOTA-biotin (ANTINEOPLASTIC RADIOPHARMACEUTICALS)" + }, + { + "input": "Definition: Intellectual Disability described as a rare multiple developmental anomalies syndrome with characteristics of the triad of ectodermal dysplasia (mostly hypohidrotic with dry skin and reduced sweating and sparse, fair scalp hair, eyebrows and eyelashes), severe intellectual disability and variable central nervous system anomalies (cerebellar hypoplasia, dilatation of ventricles, corpus callosum agenesis, Dandy-Walker malformation). Distinct craniofacial dysmorphism with macrocephaly, frontal bossing, midfacial hypoplasia and high arched or cleft palate as well as cryptorchidism, feeding difficulties and hypotonia is associated. There have been no further descriptions in the literature since 1998.", + "output": "Ectodermal dysplasia, intellectual disability, central nervous system malformation syndrome (Mental Retardation)" + }, + { + "input": "Definition: Intellectual Product described as neuropsychiatric Inventory (NPI) Does the patient do any other activities over and over?", + "output": "NPI1-Other Repetitive Activities (Intellectual Product)" + }, + { + "input": "Definition: Ichthyoses described as precancerous thick and scaly patches of skin", + "output": "Keratosis (Skin Neoplasms)" + }, + { + "input": "Definition: something described as a question about the extent to which an individual has or had to hurry to get to the toilet when they feel or felt the urge to pass urine.", + "output": "When Feel Urge to Pass Urine Have to Hurry to Get to Toilet (Intellectual Product)" + }, + { + "input": "Definition: something described as a malignant mesothelioma that has not spread beyond its original site of growth.", + "output": "Mesothelioma malignant localized (Neoplastic Process)" + }, + { + "input": "Definition: Mixed Category Laboratory Procedure described as a measurement of the volume of a biological specimen.", + "output": "Volume Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Hepatobiliary Disorder described as enlarged liver.", + "output": "LIVER ENLARGEMENT (Hepatomegaly)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the angiotensin I hormone in a biological specimen.", + "output": "Angiotensin I Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Anatomical Abnormality described as extreme cant to the condylar head beyond the usual normal range.", + "output": "Atypical condylar angulation of mandible (Deformity of mandibular condyle)" + }, + { + "input": "Definition: something described as terminology relevant to the test cnames that describe findings about a Duchenne muscular dystrophy event or intervention.", + "output": "Duchenne Muscular Dystrophy Findings About Test Name (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Drowsiness Visual Analogue Scale described as a subjective score of 9 on a drowsiness scale that ranges from 0: No Drowsiness to 10: Worst Possible Drowsiness.", + "output": "Drowsiness Score 9 (Drowsiness Visual Analogue Scale)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity.", + "output": "downregulation of beta1-adrenergic receptor activity (negative regulation of G protein-coupled receptor signaling pathway)" + }, + { + "input": "Definition: Virus Diseases described as infection by a member of the Herpesviridae family, a family of enveloped, linear, double-stranded DNA viruses; occurs in a wide variety of animals.", + "output": "E-320-327 DISEASES DUE TO HERPESVIRIDAE (Immunology)" + }, + { + "input": "Definition: Pharmacologic Substance described as possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.", + "output": "allylamine (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: proton-transporting two-sector ATPase complex, proton-transporting domain described as a protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.", + "output": "proton-transporting V-type ATPase, V0 domain (proton-transporting two-sector ATPase complex, proton-transporting domain)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Multiple Sclerosis (FAMS) Family/Social Well-Being: My family has trouble understanding when my condition gets worse.", + "output": "FAMS01-Trouble Understanding Worsening (FAMS Questionnaire Question)" + }, + { + "input": "Definition: something described as to cause a high-priority signal (or warning) to be transmitted to the relevant stakeholder by way of the local system or another system (usually according to an established set of rules). For example, the system may transmit an alert to a patient's cardiologist that the patient has experienced another heart attack. another example is that the pharmacy system may transmit an alert to the prescribing physician that a potentially dangerous drug-drug interaction may occur based on the current list of medications. another example is that the system may notify a patient's physician that laboratory results (that are not within normal limits) are available.", + "output": "alert (Signal)" + }, + { + "input": "Definition: something described as a regimen consisting of cyclophosphamide, mitoxantrone, vincristine and prednisone used to treat both indolent and aggressive forms of non-Hodgkin lymphoma.", + "output": "Cytoxan-Novantrone-Oncovin-Prednisone Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: follicular fluid formation in ovarian follicle antrum described as the menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.", + "output": "follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol.", + "output": "negative regulation of response to butan-1-ol (negative regulation of response to alcohol)" + }, + { + "input": "Definition: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway described as any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.", + "output": "positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)" + }, + { + "input": "Definition: Body part described as the hollow tube inside the neck that starts behind the nose and ends at the top of the trachea (windpipe) and esophagus (the tube that goes to the stomach). The pharynx is about 5 inches long, depending on body size.", + "output": "Pharynx, NOS (Upper digestive tract structure)" + }, + { + "input": "Definition: Classification described as the classification of a living space.", + "output": "Housing Type (Classification)" + }, + { + "input": "Definition: Journalism described as the collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.", + "output": "MED JOURNALISM (Journalism)" + }, + { + "input": "Definition: something described as an indication that it is not known what tests were performed during the study.", + "output": "Not Known if Testing Was Performed (Finding)" + }, + { + "input": "Definition: Medical Device described as a pliable length of fabric, plastic, paper or some composite that is has incremental lengths imprinted on the surface.", + "output": "Measuring tape, device (Medical Devices)" + }, + { + "input": "Definition: regionalization described as the regionalization process that divides the spatial regions of an embryo into serially repeated regions.", + "output": "periodic partitioning (regionalization)" + }, + { + "input": "Definition: something described as pathogenic", + "output": "nuc ish(13q14x1)[60]/(13q14x2)[40] (Finding)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of reviewable unit. EXAMPLE(S): toxicology, safety, manufacturing, administrative OTHER NAME(S): NOTE(S):", + "output": "Reviewable Unit Type Code (Intellectual Product)" + }, + { + "input": "Definition: something described as the process in which the left cardiac ventricle is generated and organized.", + "output": "cardiac left ventricle morphogenesis (Organism Function)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter G described as tian ma", + "output": "gastrodiae/tian ma (Plant)" + }, + { + "input": "Definition: something described as the assessed level of knowledge of a community, subpopulation, or population.", + "output": "Nutrition knowledge of community (Finding)" + }, + { + "input": "Definition: Umbelliferones described as a coumarin compound found in several plants including those in the genus Scopolia and the genus Brunfelsia, as well as chicory (Cichorium), redstem wormwood (Artemisia scoparia), stinging nettle (Urtica dioica), passion flower (Passiflora), noni (Morinda citrifolia fruit) and European black nightshade (Solanum nigrum) that is comprised of umbelliferone with a methoxy group substituent at position 6. Scopoletin is used to standardize and establish pharmacokinetic properties for products derived from the plants that produce it, such as noni extract. Although the mechanism(s) of action have not yet been established, this agent has potential antineoplastic, antidopaminergic, antioxidant, anti-inflammatory and anticholinesterase effects.", + "output": "Gelseminic Acid (Organic Chemical)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in transcriptional regulation.", + "output": "NOCA-LIKE ZINC FINGER 1 (Transcription Regulation Gene)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as enzymes that catalyze the shifting of a carbon-carbon double bond from one position to another within the same molecule. EC 5.3.3.", + "output": "C-C Double Bond Isomerases (Enzyme)" + }, + { + "input": "Definition: something described as a tricolor rugged and determined mover of cattle with a short, soft coat. The average height is 21 inches and the average weight range is 40-65 pounds.", + "output": "Entlebucher Mountain Dog (Mammal)" + }, + { + "input": "Definition: Body position described as the posture of an individual supported by the knees and chest resting on a table.", + "output": "Knee-Chest Position (MUSCULOSKELETAL FUNCTIONS: GENERAL TERMS)" + }, + { + "input": "Definition: Autoimmune antibody positivity described as the presence in the serum of autoantibodies directed against thrombocytes.", + "output": "Platelet antibody (Laboratory or Test Result)" + }, + { + "input": "Definition: Telecommunication Address described as a sequence of digits or characters used to identify a particular telephone, fax, or email of the service delivery location.", + "output": "ServiceDeliveryLocation.telecomAddress (Intellectual Product)" + }, + { + "input": "Definition: Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC v8 described as stage IA includes: (T1a, N0, M0, G1, Tumor location: Any); (T1a, N0, M0, GX, Tumor location: Any). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed.", + "output": "Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving syringal lignin.", + "output": "S-lignin metabolic process (lignin metabolic process)" + }, + { + "input": "Definition: something described as synthetic polymer tubing made of silicone, an elastomer also known as silicone rubber. Silicone tubing is typically a small-diameter, hollow, flexible or semirigid cylinder designed for the transfer of fluids, either liquids or gases; it can be made with different structures (e.g., reinforced) according to the intended use. Silicone tubing is usually available in standardized lengths and in a variety of diameters and wall thicknesses (i.e., gauges) that permit the use of segments of different sizes appropriate for a given application in the healthcare facility, especially when high resistance to oils and chemicals is needed.", + "output": "silicone tube (Medical Device)" + }, + { + "input": "Definition: Inotropic agent described as group of substances obtained from species of Digitalis, Strophanthus, and other plants that contain specific steroid glycosides or their semisynthetic derivatives and used in congestive heart failure; they increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses; their mechanism of action usually involves inhibition of the Na(+)-K(+)-exchanging ATPase and they are often used in cell biological studies for that purpose.", + "output": "Glycosides, Cardiac (Allergen class)" + }, + { + "input": "Definition: Finding described as kidney cancer with metastasis in regional lymph node(s).", + "output": "Kidney Cancer pN1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Disease due to Betaretrovirus described as a contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.", + "output": "Pulmonary Carcinomas, Ovine (Adenoma of lung)" + }, + { + "input": "Definition: Time described as the time for a fixed reference time point.", + "output": "Time of Reference Time Point (Time)" + }, + { + "input": "Definition: Injury by mechanism described as the pathologic wearing away of the tooth substance by brushing, bruxism, clenching, and other mechanical causes. It is differentiated from TOOTH ATTRITION in that this type of wearing away is the result of tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces. It differs also from TOOTH EROSION, the progressive loss of the hard substance of a tooth by chemical processes not involving bacterial action.", + "output": "abrasion of teeth (Tooth Abrasion)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a liquid dose form consisting of active substance(s) in an alcohol.", + "output": "Spirit (Biomedical or Dental Material)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium.", + "output": "Abnormality of the sacroiliac notch (Anatomical Abnormality)" + }, + { + "input": "Definition: MPP2 gene described as human MPP2 wild-type allele is located within 17q12-q21 and is approximately 32 kb in length. This allele, which encodes MAGUK p55 subfamily member 2 protein, plays a role in coupling the cytoskeleton to the cell membrane and is putatively involved in signal transduction.", + "output": "Membrane Palmitoylated Protein 2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Disease or Syndrome described as infestation with larvae of the genus Hypoderma, the warble fly.", + "output": "Hypodermyiases (Disease or Syndrome)" + }, + { + "input": "Definition: Multiple malformation syndrome with early overgrowth described as congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.", + "output": "soto syndrome (Musculoskeletal disorders congenital NEC)" + }, + { + "input": "Definition: Organism Function described as heat production in the body by muscular activity (e.g. shivering), food intake, or increased metabolic rate, frequently hormonally regulated.", + "output": "Thermogenesis (Physiologic Thermoregulation)" + }, + { + "input": "Definition: something described as a population of autologous cytotoxic T lymphocytes (CTLs) with potential immunomodulating and antitumor activities. White blood cells are grown ex-vivo and are exposed to dendritic cells (DCs) loaded with lymphoma tumor associated antigens (TAAs); the TAA-specific CTLs are further expanded ex-vivo before being introduced into the patient. Upon infusion with TAA-specific CTLs, these CTLs may help activate tumor-specific CTL responses in the patient, thereby specifically killing TAA-expressing cancer cells and eventually inhibiting tumor cell proliferation.", + "output": "Lymphoma TAA-specific Cytotoxic T Lymphocytes (Cell)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the polychromatophilic normoblasts in a biological specimen taken from a non-human organism.", + "output": "Polychromatophilic Normoblast Count (Laboratory Procedure)" + }, + { + "input": "Definition: Renal hypocalciuria described as an inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.", + "output": "Familial Hypokalemia-Hypomagnesemia (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Gene or Genome described as human FURIN wild-type allele is located in the vicinity of 15q26.1 and is approximately 15 kb in length. This allele, which encodes furin protein, plays a role in the cleavage of proteins containing paired basic amino-acid residues to release mature proteins from their precursor proteins.", + "output": "FUR (Gene or Genome)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 1634 of the coding sequence of the PIK3CA gene where adenine has been mutated to thymine.", + "output": "NM 006218.1:c.1634A>T (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as an abnormally increased sensitivity to the effects of ionizing radiation.", + "output": "Increased sensitivity to ionizing radiation (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question associated with the NHPT functional test.", + "output": "NHPT Functional Test Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a copper test system is a device intended to measure copper levels in plasma, serum, and urine. Measurements of copper are used in the diagnosis and treatment of anemia, infections, inflammations, and Wilson's disease (a hereditary disease primarily of the liver and nervous system). Test results are also used in monitoring patients with Hodgkin's disease (a disease primarily of the lymph system).", + "output": "OXALYDIHYDRAZIDE (SPECTROSCOPIC), COPPER (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Complement System Proteins described as a subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.", + "output": "Complement Component 1q (Immunologic Factor)" + }, + { + "input": "Definition: Biologically Active Substance described as cullin-3 (768 aa, ~89 kDa) is encoded by the human CUL3 gene. This protein plays a role in protein ubiquitination and cell cycle arrest.", + "output": "CUL-3 (Ubiquitination Regulation Protein)" + }, + { + "input": "Definition: something described as a kind of depression treatment drug", + "output": "TRAZODONE (Organic Chemical)" + }, + { + "input": "Definition: Granulomatous disorder described as an excessive number of histiocytes (tissue macrophages).", + "output": "Histiocytic Syndrome (Histiocytosis)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.", + "output": "scavenger receptor binding (Molecular Function)" + }, + { + "input": "Definition: cytosine nucleoside described as a drug that protects healthy tissues from the toxic effects of anticancer drugs.", + "output": "1-(2-deoxy-.beta.-d-ribofuranosyl)cytosine (pyrimidine analog)" + }, + { + "input": "Definition: something described as any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.", + "output": "positive regulation of inclusion body assembly (positive regulation of cellular component organization)" + }, + { + "input": "Definition: something described as a data storage device for which the order of access to different locations does not affect the speed of access. RAM can be both read from and written to by the computer, but its contents are lost when the power is switched off.", + "output": "Random Access Memory (Memory Device)" + }, + { + "input": "Definition: Disease or Syndrome described as a closed funnel detachment of the retina with generally traction in all four quadrants.", + "output": "ROP stage 5b (Disease or Syndrome)" + }, + { + "input": "Definition: Pharmacologic Substance described as a dual peroxisome proliferator-activated receptor (PPAR) agonist, with hypoglycemic activity. Muraglitazar causes an increase in HDL-C levels, and a decrease in total cholesterol, apolipoprotein B, triglycerides and HbA1c. This agent is associated with an increased risk of adverse cardiovascular events and heart failure.", + "output": "MURAGLITAZAR (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as poison, usually protein, produced by or accumulating in marine organisms that is toxic to other living organisms.", + "output": "marine toxin (Neurotoxins)" + }, + { + "input": "Definition: something described as the process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.", + "output": "oxidised LDL particle clearance (Cell Function)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+.", + "output": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity (hexosyltransferase activity)" + }, + { + "input": "Definition: something described as administration by injection through the membrane covering the muscles and nerves at the back of the eyeball.", + "output": "Subtenon Route of Administration (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as prostate cancer which is organ confined.", + "output": "Prostate Cancer pT2 TNM Finding v8 (Prostate Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a form of combined androgen blockade consisting of flutamide and leuprolide used to treat metastatic prostate cancer. This approach has been widely replaced by the use of either surgical (orchiectomy) or medical (LHRH agonist) castration.", + "output": "Flutamide/Leuprolide Regimen (Regimen Used to Treat Prostate Carcinoma)" + }, + { + "input": "Definition: Abnormality of urine homeostasis described as any deviation of the concentration of one or more proteins in the urine. []", + "output": "Abnormal urine protein level (Finding)" + }, + { + "input": "Definition: Reference Period described as an abstraction belonging to or characteristic of a point or period to something that refers or points to an interval of time characterized by the occurrence of a certain condition, event, or phenomenon.", + "output": "Relation to Reference Period (Reference Period)" + }, + { + "input": "Definition: Immunologic Deficiency Syndromes described as a condition of decreased or absent presence or activity of V(D)J recombination-activating protein 1. Deficiency of this protein is associated with Omenn syndrome, severe combined immunodeficiency, b cell-negative, combined cellular and humoral immune defects with granulomas, and alpha/beta T-cell lymphopenia with gamma/delta T-cell expansion, severe cytomegalovirus infection, and autoimmunity.", + "output": "Hypomorphic Rag1 deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: Animal described as a non-human living organism that has membranous cell walls, requires oxygen and organic foods, and is capable of voluntary movement, as distinguished from a plant or mineral. EXAMPLE(S): dog, cat, mouse, microorganism OTHER NAME(S): NOTE(S):", + "output": "Animal, NOS (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: something described as a measure of the range of values in a set of values that describe the diameter of an entity.", + "output": "Standard Deviation of Diameter (Standard deviation)" + }, + { + "input": "Definition: Thorax excision described as the removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out.", + "output": "Mastectomies, Limited Resection (Thorax excision)" + }, + { + "input": "Definition: Enzyme Inhibitor Drugs described as an orally bioavailable oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity. Upon administration of the OxPhos inhibitor IACS-010759, this agent binds to and inhibits complex I of the electron transport chain (NADH ubiquinone oxidoreductase), thereby selectively depriving tumor cells of nutrients, and energy, and inhibiting nucleotide and amino acid production, which induces autophagy, causes tumor cell death and inhibits cell proliferation. Mitochondrial complex I, which is hyperactivated in cancer cells to meet their increased demands for energy, plays a key role in the promotion of cancer cell proliferation.", + "output": "OXPHOS inhibitor IACS-010759 (Enzyme Inhibitor Drugs)" + }, + { + "input": "Definition: response to testosterone described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.", + "output": "cellular response to testosterone stimulus (Cell Function)" + }, + { + "input": "Definition: Finding described as device and/or fragments of device are embedded in patient's vessel and/or plaque.", + "output": "Vessel Or Plaque, Device Embedded In (Finding)" + }, + { + "input": "Definition: Malignant neoplasm of genitourinary organ described as a primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas.", + "output": "Cancer, Urinary Tract (Cancer of Urinary Tract)" + }, + { + "input": "Definition: something described as an orally active and small molecule inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins.", + "output": "Hsp90 inhibitor DS-2248 (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as a reduction in the strength of the muscles in the left side of the body.", + "output": "Muscle Weakness Left-Sided (Finding)" + }, + { + "input": "Definition: Qualitative Concept described as a description of the quantity or quality of the hair or fur covering a mass.", + "output": "Mass Hair Cover (Qualitative Concept)" + }, + { + "input": "Definition: something described as a chemotherapy combination consisting of bleomycin, cyclophosphamide, doxorubicin, prednisolone, and vindesine that can be used for the treatment of lymphoma.", + "output": "LNH-84 Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual lacks sitting balance and is unable to sit or transfer.", + "output": "unable, no sitting balance (Ability to transfer location)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that a person emotionally dislikes their extremity.", + "output": "Dislikes (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib sodium is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90541\" active clinical trials using this agent.", + "output": "Phenol, 2-Methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(Dihydrogen Phosphate), Sodium Salt (Organic Chemical)" + }, + { + "input": "Definition: Gene or Genome described as human TSGA10 wild-type allele is located in the vicinity of 2q11.2 and is approximately 158 kb in length. This allele, which encodes testis-specific gene 10 protein, may be involved in the formation of the fibrous sheath of the sperm tail.", + "output": "CEP4L (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Naming task for object 1.", + "output": "Naming Objects and Fingers: 1 (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as substances capable of increasing BODY TEMPERATURE and cause FEVER and may be used for FEVER THERAPY. They may be of microbial origin, often POLYSACCHARIDES, and may contaminate distilled water.", + "output": "pyrogens (Pharmaceutical Preparations)" + }, + { + "input": "Definition: something described as significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; limiting self care ADL", + "output": "Grade 3 Musculoskeletal deformity (Finding)" + }, + { + "input": "Definition: IDUA gene described as human IDUA wild-type allele is located in the vicinity of 4p16.3 and is approximately 18 kb in length. This allele, which encodes alpha-L-iduronidase protein, is involved in the metabolism of glycosaminoglycans. Mutation of the gene is associated with mucopolysaccharidosis type 1.", + "output": "MPS1 (IDUA gene)" + }, + { + "input": "Definition: gastrointestinal circulation disorder described as abnormally dilated veins of the esophagus.", + "output": "OV - Esophageal varices (Gastrointestinal Diseases)" + }, + { + "input": "Definition: Esters described as a family of benzene derivatives that are formed by esterification of phthalic acid. Phthalates are added to increase the flexibility and softness of commercial plastics, which are incorporated into a wide variety of consumer goods. Ingested phthalates may exhibit estrogenic or antiandrogenic effects or they may act as endocrine disruptors. Exposure to phthalate may increase the risk of certain cancers.", + "output": "Phthalate (PLASTICS AND RELATED COMPOUNDS)" + }, + { + "input": "Definition: something described as an arrhythmia detector and alarm is a system that monitors the electrocardiogram and is designed to produce a visible or audible signal or alarm when an atrial or ventricular arrhythmia, such as a premature contraction or ventricular fibrillation, exists.", + "output": "MONITOR, ST SEGMENT WITH ALARM (Medical Device)" + }, + { + "input": "Definition: Physiologic Responses described as observes for manifestations of tissue reaction due to pathogenic microorganism invasion of the body and communicates hospital-acquired infections to the infection control representative and collaborates in the revised plan of care.", + "output": "Evaluates for hospital-acquired infections following the perioperative procedure (Physiologic Responses)" + }, + { + "input": "Definition: Intellectual Product described as disability Rating Scale (DRS) Level of functioning (physical, mental, emotional or social function).", + "output": "DRS0107 (DRS Questionnaire Question)" + }, + { + "input": "Definition: Magnocellular hypothalamic nuclei described as one of the magnocellular hypothalamic nuclei, an elongated plate of large, deeply staining cells located close to the third ventricle in the anterior hypothalamic area; major source of oxytocin and to a lesser extent, of antidiuretic hormone, neurohormones, which are carried to the neurohypophysis along the paraventriculohypophysial tract.", + "output": "subcommissural nucleus (Hypothalamic structure)" + }, + { + "input": "Definition: Medical Device described as an electronic noise generator for audiometric testing is a device that consists of a swept frequency generator, an amplifier, and an earphone. It is intended to introduce a masking noise into the non-test ear during an audiometric evaluation. The device minimizes the non-test ear's sensing of test tones and signals being generated for the ear being tested.", + "output": "GENERATOR, ELECTRONIC NOISE (Medical Device)" + }, + { + "input": "Definition: Pill Counters described as equipment designed for counting and verifying of the quantity of pills included in a given container following a pre-established program. These machines consist of a computerized unit that includes conveyors, input and output ports for the pill containers, barcode readers, cameras, and a processor that follows a dedicated software. The machines make it possible to count the quantity of pills in unit-dose or multi-dose containers, compare with the expected quantity, and keep record of the pills in each container. New types of pills to be introduced in the systems should be programmed prior to the process of counting and verification. Pill counting/verification units may be used as stand-alone units or as components of pill distribution systems in healthcare facilities (e.g., pharmacies, hospitals).", + "output": "Pill Packing Units, Counting/Verification (Manufactured Object)" + }, + { + "input": "Definition: Neoplastic Process described as a hepatoblastoma composed of cells resembling fetal epithelial cells and small round cells resembling blastema cells.", + "output": "Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation (Hepatoblastoma)" + }, + { + "input": "Definition: something described as inflammation of the alveoli of the lung.", + "output": "Pulmonary Alveolitis (Disease or Syndrome)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as brand name of imidacloprid insecticide", + "output": "Advantage (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "output": "regulation of pigmentation during development (Regulation of biological process)" + }, + { + "input": "Definition: Medical Device described as video cameras designed for attachment as an integral component at the distal end of a flexible or rigid video endoscope. These cameras usually include appropriate semiconductor sensors (e.g., CCD, C-MOS) located at the distal tip of the endoscope; the captured signal is delivered through fiber optics to the proximal end of the endoscope and then sent to a video processor. Endoscope tip video cameras are intended for picture documentation of the endoscopic findings and/or for instantaneous display of the images; facilitating diagnoses and/or making possible the performance of real-time therapy and/or surgical procedures through the endoscope.", + "output": "Cameras, Video, Endoscope Tip (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 4 Weeks Version - These are questions about what activities usually make you feel short of breath these days: Walking up hills.", + "output": "SGRQ Past 4 Weeks Version - Walking Up Hills (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)" + }, + { + "input": "Definition: something described as the single family of PRIMATES in the infraorder TARSII, suborder HAPLORHINI. It is comprised of one genus, Tarsius, that inhabits southern Sumatra, Borneo, Sulawesi, and the Philippines.", + "output": "Tarsier, NOS (Tarsiidae)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as a type of digital polymerase chain reaction technique in which the sample is fractionated into thousands of tiny droplets using a water-oil emulsion droplet technology, within which individual PCR reactions occur in each droplet.", + "output": "Droplet Digital PCR (Digital Array)" + }, + { + "input": "Definition: neoplasm of soft tissue of types described as a benign, intermediate, or malignant mesenchymal neoplasm composed of adipose (fatty) tissue.", + "output": "neoplasm of adipose tissue (Lipomatous neoplasm)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Virus, Respiratory Syncytial Virus, Antibody described as serology reagents intended to detect immunoglobulin M (IgM) antibodies to respiratory syncytial virus (RSV), an enveloped RNA species of the genus Pneumovirus, family Paramyxovirus. Several types of RSV are etiologic agents of lower respiratory tract infections; they are the most common cause of bronchiolitis and pneumonia among infants.", + "output": "IVD Test Reagent/Kits, Serology, Virus, Respiratory Syncytial Virus, IgM Antibody (IVD Test Reagent/Kits, Serology, Virus, Respiratory Syncytial Virus, Antibody)" + }, + { + "input": "Definition: something described as a rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells. The cells display hyperchromic nuclei and well-defined cytoplasmic borders.", + "output": "Gallbladder Clear Cell Adenocarcinoma (Malignant neoplasm of gallbladder)" + }, + { + "input": "Definition: V [Preparations] described as does not occur in nature, propagated in the laboratory for use as an active vaccine against smallpox; possibly a derivative or recombinant of cowpox or smallpox viruses; used experimentally as a vector for genes expressing foreign protein antigens.", + "output": "vaccinia virus VV (Pox Viruses Subgenus A)" + }, + { + "input": "Definition: Operation on fallopian tube described as combined surgical resection of the fallopian tube and the ovary.", + "output": "Salpingo-Oophorectomy (Fallopian tube therapeutic procedures)" + }, + { + "input": "Definition: Allogeneic Lymphocyte described as a preparation of allogeneic, genetically engineered T-lymphocytes transduced with a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR), with potential antineoplastic activity. The TCR especially recognizes and binds with high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing T-cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16 E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation. E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface of HPV-16 positive, HLA-A*02:01-positive tumor cells.", + "output": "human papillomavirus type 16 E7 TCR expressing T cells (T-cell Receptor-engineered T-cells)" + }, + { + "input": "Definition: something described as a finding of cerebellar astrocytoma in childhood that has not been treated.", + "output": "untreated pediatric cerebellar astrocytoma (Childhood Cerebellar Astrocytoma)" + }, + { + "input": "Definition: Steroid measurement described as a measurement of the androgen status in a biological specimen. This is calculated by a mathematical formula that takes into account the total testosterone level, sex hormone binding globulin, and a constant.", + "output": "Free androgen index (Reproductive hormone analyses)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.", + "output": "inositol diphosphate tetrakisphosphate kinase activity (Molecular Function)" + }, + { + "input": "Definition: Neoplastic Process described as stage II includes: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis.", + "output": "Stage II Differentiated Thyroid Gland Cancer 55 Years and Older (Stage II Differentiated Thyroid Gland Carcinoma AJCC v8)" + }, + { + "input": "Definition: regulation of protein localization to cell cortex described as any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.", + "output": "up-regulation of protein localization to cell cortex (positive regulation of protein localization to cell periphery)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate.", + "output": "D-lactate dehydrogenase (cytochrome c-553) activity (Molecular Function)" + }, + { + "input": "Definition: Spectrometers described as a mass spectrometer for clinical use is a device intended to identify inorganic or organic compounds (e.g., lead, mercury, and drugs) in human specimens by ionizing the compound under investigation and separating the resulting ions by means of an electrical and megnetic field according to their mass.", + "output": "Spectrometers, Mass (Spectrometers)" + }, + { + "input": "Definition: something described as an instrument for counting the number of steps taken while walking. This information can be used to estimate the distance traveled or calories used.", + "output": "Pedometers (Instrument - device)" + }, + { + "input": "Definition: Interphase described as progression from G2 phase to M phase of the standard mitotic cell cycle.", + "output": "G2 to M Transition Process (Molecular Function)" + }, + { + "input": "Definition: Vulval cancer stage III described as stage IIIB includes: (T1/T2, N2a/N2b, M0). T1: Invasive vulvar cancer confined to the vulva or perineum. T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement). N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less. N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater. M0: No distant metastasis. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C89448\" active clinical trials using this agent.", + "output": "Stage IIIB Vulvar Cancer (Vulval cancer stage III)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter Y described as any elsewhere undefined Oriental herb and natural substance, letter Y, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "undef.Orntl hrb&ntrl subst l (Oriental herbs and natural substances letter Y)" + }, + { + "input": "Definition: Enzyme Inhibitor Drugs described as an orally bioavailable inhibitor of glutaminase, with potential antineoplastic and immunostimulating activities. Upon oral administration, IPN60090 selectively targets, binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate. Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.", + "output": "IPN 60090 (Organic Chemical)" + }, + { + "input": "Definition: something described as human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for NY-ESO-1:157-165.", + "output": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as an orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.", + "output": "peretinoin (Retinoids)" + }, + { + "input": "Definition: something described as a plant with seeds that are used as a mild laxative. The outer layer of the seeds swells when wet. This increases the size of stool and helps it pass more easily through the intestines (lower part of the digestive tract). Psyllium is a type of bulk laxative.", + "output": "Psyllium Husk (Laxatives)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a percutaneous coronary intervention is necessary for a myocardial infarction that presents with ST segment elevation and the subject has recurrent or persistent symptoms, symptoms of heart failure or ventricular arrhythmia. The presentation is past twelve hours since onset of symptoms.", + "output": "Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction-Unstable-Over 12 Hours From Symptom Onset (Cardiovascular Surgical Procedures)" + }, + { + "input": "Definition: Oxidoreductase Gene described as this gene plays a role in the oxidative metabolism of purines.", + "output": "xanthene dehydrogenase (Oxidoreductase Gene)" + }, + { + "input": "Definition: Radiology Specialty described as special field of radiology dealing with diagnostic, therapeutic and investigative use of radioisotopes and radioactive compounds.", + "output": "Medicine, Atomic (Medical Specialities)" + }, + { + "input": "Definition: Canis familiaris described as a heavily wrinkled dog with a large head, though dogs with smaller heads and tighter looking skins do occur in this breed. Puppies have more wrinkles than adults. Shar-Peis slowly loose their wrinkles as they get older. There are three coat varieties: horse-coat, brush-coat, and a rare bear-coat. The unusual horse-coat is rough to the touch, prickly, and off-standing. The brush-coated variety has longer hair and a smoother feel. The coat on either variety can be up to one inch in length. Coat colors include all solid colors and sables. The average height range is 18-20 inches and the average weight range is 40-55 pounds.", + "output": "Shar-Pei (Non-Sporting Breed)" + }, + { + "input": "Definition: Ventilation or Perfusion Signs and Symptoms described as abnormal breath sounds caused by the accumulation of fluid in the lungs.", + "output": "Crepitation;chest (Abnormal breath sounds)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of macropinocytosis.", + "output": "regulation of macropinocytosis (Cell Function)" + }, + { + "input": "Definition: something described as named or selected to an assignment.", + "output": "Designated (General Qualifier)" + }, + { + "input": "Definition: cation binding described as reference to a chemical group or moiety that can complex or chelate a metal ion.", + "output": "Metal Ion Binding (Chelating Activity)" + }, + { + "input": "Definition: Tobacco described as flavored tobacco whose vapor or smoke is passed through a water basin before inhalation.", + "output": "Water Pipe Tobacco (Tobacco)" + }, + { + "input": "Definition: Coccidiostats described as a coccidiostat for poultry.", + "output": "3-Quinolinecarboxylic acid, 6-(decyloxy)-7-ethoxy-4-hydroxy-, ethyl ester (Organic Chemical)" + }, + { + "input": "Definition: Classification described as the status of central nervous system leukemia at diagnosis, where there are 10 or more red blood cells and 5 or more white blood cells per microliter on a cerebral spinal fluid cytospin preparation that is considered positive by Steinherz/Bleyer algorithm.", + "output": "CNS3b (Classification)" + }, + { + "input": "Definition: Disease described as a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.", + "output": "Autoimmune disease, NOS (Disease)" + }, + { + "input": "Definition: something described as a radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with indium In 111 (In-111). Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. In 111-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.", + "output": "In 111-DOTA-Biotin (Organic Chemical)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure.", + "output": "embryonic meristem development (meristem development)" + }, + { + "input": "Definition: something described as a pathway containing fibers from nuclei of the hypothalamus that project to the dorsal tegmental nucleus and other regions of the midbrain and the pons, as well as fibers originating in the pontine reticular formation and the medullary reticular formation that project to the thalamus and other regions of the forebrain ( Carpenter-1983 ). In NeuroNames, it is a composite structure consisting of the dorsal longitudinal fasciculus of the hypothalamus, the dorsal longitudinal fasciculus of the midbrain, the dorsal longitudinal fasciculus of the pons and the dorsal longitudinal fasciculus of the medulla.", + "output": "Fasciculus periaquaeductalis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: S [Preparations] described as a dietary protein isolated from soybeans that contains isoflavone phytoestrogens. Soy protein isolate has been shown to reduce tumor incidence and growth in some animal studies, possibly by modulating estrogen metabolism, reducing tumor cell proliferation, and inducing tumor cell apoptosis. Soy protein isolate may also inhibit endothelial cell proliferation. Isoflavone phytoestrogens display mild estrogen-like activities which may regulate hormone balance and reduce the risks of breast cancer, heart disease, and osteoporosis.", + "output": "soy protein isolate (Pharmacologic Substance)" + }, + { + "input": "Definition: Mycosis Fungoides described as histologic transformation of mycosis fungoides to an aggressive non-Hodgkin lymphoma.", + "output": "Transformed Mycosis Fungoides (Neoplastic Process)" + }, + { + "input": "Definition: alpha-Thalassemia described as a condition in which a person has reduced protein production from one of the four alpha-globin alleles.", + "output": "Alpha Thalassemia Silent Carrier (Hemoglobin Trait)" + }, + { + "input": "Definition: Encounter due to specified procedures and aftercare described as vital information about a donor at the time of donation.", + "output": "Donor status (Status)" + }, + { + "input": "Definition: something described as a method to determine microbial susceptibility to antibiotics in which an agar plate, which has a concentration gradient of the drug within the agar, is streaked with the microorganism of interest. Microbial susceptibility as well as minimum inhibitory concentration of antibiotic is assessed.", + "output": "Gradient Diffusion Method (Microbial susceptibility tests)" + }, + { + "input": "Definition: Clinical actions H - O described as a construction of a pouch, achieved by resecting the anterior wall of a cyst or other enclosed cavity and suturing the cut edges of the remaining wall to adjacent edges of skin", + "output": "marsupialisation (Structural modification)" + }, + { + "input": "Definition: Kaposi Sarcoma described as a syndrome that occurs in a proportion of patients with HIV infection and Kaposi sarcoma after initiation of highly active antiretroviral therapy. It is characterized by a deterioration in their clinical status, despite control of virologic and immunologic parameters.", + "output": "Kaposi Sarcoma Immune Reconstitution Syndrome (Retroviridae Infections)" + }, + { + "input": "Definition: something described as a measurement of the N-terminal proB-type natriuretic peptide in a biological specimen.", + "output": "N-terminal pro-Brain Natriuretic Peptide (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Diaphyses described as the prismatic, elongated bony body of the ulna.", + "output": "Ulnar Shaft (Ulna Part)" + }, + { + "input": "Definition: Medical Devices described as a device used to deliver drugs directly to the cervix (the lower, narrow end of the uterus that forms a canal between the uterus and vagina). The CerviPrep covers the cervix and protects surrounding tissue. Drugs may be injected into the inner part of the cervix through a syringe attached to the device.", + "output": "CerviPrep (Medical Devices)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - If you answered \"no\" to Question 36 above, was your child's activity limited by: Pain?", + "output": "PODCI Pediatric Parent-Reported Version - Outdoor Limited by: Pain (Intellectual Product)" + }, + { + "input": "Definition: sulfotransferase activity described as catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.", + "output": "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as an undifferentiated pleomorphic sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.", + "output": "Locally Advanced Undifferentiated Pleomorphic Sarcoma (Locally Advanced Soft Tissue Sarcoma)" + }, + { + "input": "Definition: Midbrain part described as ventral portion of the mesencephalon including the MIDBRAIN TEGMENTUM; CRUS CEREBRI; and the PRETECTUM. It does not include tectum mesencephali and TROCHLEAR NERVE.", + "output": "Basis pedunculi (Brain part)" + }, + { + "input": "Definition: something described as the in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.", + "output": "Gene Fusions, Artificial (Cloning, Molecular)" + }, + { + "input": "Definition: B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities described as a precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein. It has a favorable clinical outcome.", + "output": "B lymphoblastic leukemia lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) (Acute lymphocytic leukemia)" + }, + { + "input": "Definition: Pulmonary Valve Disorder described as a congenital heart defect characterized by complete atresia of the pulmonary valve. It is manifested during infancy with cyanosis, dyspnea, and tachypnea.", + "output": "Atresia of pulmonary valve (Pulmonary Valve Disorder)" + }, + { + "input": "Definition: something described as a complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides.", + "output": "virus terminase complex (Cell Component)" + }, + { + "input": "Definition: Ultrasonic Therapy described as a form of treatment that uses very high frequency sound waves for the purpose of treating an injury or illness.", + "output": "Ultrasonic Therapy (Procedures and interventions, Not Elsewhere Classified)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of tissue plasminogen activator antigen present in a sample.", + "output": "Tissue Plasminogen Activator Antigen (Laboratory Procedure)" + }, + { + "input": "Definition: Archaeon described as a genus of aerobic, chemolithotrophic, coccoid ARCHAEA whose organisms are thermoacidophilic. Its cells are highly irregular in shape, often lobed, but occasionally spherical. It has worldwide distribution with organisms isolated from hot acidic soils and water. Sulfur is used as an energy source.", + "output": "Sulfolobus Brock et al. 1972 (Archaeon)" + }, + { + "input": "Definition: something described as a tremor transducer is a device used to measure the degree of tremor caused by certain diseases.", + "output": "Tremor transducer (Medical Device)" + }, + { + "input": "Definition: Tiredness Visual Analogue Scale described as a subjective score of 3 on a tiredness scale that ranges from 0: No Tiredness to 10: Worst Possible Tiredness.", + "output": "Tiredness Score 3 (Intellectual Product)" + }, + { + "input": "Definition: Diagnostic, Therapeutic, and Research Equipment described as bars that are attached either to the walls and floor surrounding the commode or to the commode itself. They are used to aid infirm and disabled patients in sitting and standing. They are typically made of stainless steel.", + "output": "Rails, Commode (Medical Device)" + }, + { + "input": "Definition: something described as a shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point.", + "output": "Almond-shaped palpebral fissure (inspection of palpebral fissures)" + }, + { + "input": "Definition: something described as divalent group C=O occurring in compounds such as aldehydes, ketones, carboxylic acids and esters.", + "output": "carbonyl group (chemical group)" + }, + { + "input": "Definition: Turkic language described as a Turkic language spoken by the Yakut people in the Sakha Republic in the Russian Federation.", + "output": "SAH (Turkic language)" + }, + { + "input": "Definition: Intellectual Product described as the Oswestry Disability Index Version 2.1a - Section 6 - Standing.", + "output": "ODI0106 (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a neoplasm composed of basal cells that metastasizes to other anatomic sites.", + "output": "Malignant Basal Cell Neoplasm (Basal Cell Neoplasm)" + }, + { + "input": "Definition: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation described as an allogeneic hematopoietic stem cell transplantation (HSCT) in a recipient that was not pre-treated with a conditioning regimen of high doses of chemotherapy or radiation, using cells depleted of T-cell receptors (TCR) alpha and beta as Graft-versus-Host Disease (GvHD) prophylaxis, from a related donor who is a partial human leukocyte antigen (HLA) tissue type match.", + "output": "Non-myeloablative TCR alpha/beta-depleted Haploidentical Hematopoietic Stem Cell Transplantation (Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation)" + }, + { + "input": "Definition: Substance categorized by structure described as a fine powdery material such as dry earth or pollen that can be blown about in the air.", + "output": "Dust (Substance)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with macular dystrophy, a collection of hereditary diseases involving progressive damage to a region of the retina responsible for central vision known as the macula. Genetic variants at multiple loci have been associated with macular dystrophy. These reagents are intended to detect mutations in the majority of macular dystrophy-associated loci simultaneously.", + "output": "Comprehensive Macular Dystrophy Gene Mutation Panel Reagents (Medical Device)" + }, + { + "input": "Definition: regulation of retinal cell programmed cell death described as any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.", + "output": "downregulation of retinal programmed cell death (negative regulation of programmed cell death)" + }, + { + "input": "Definition: Heterocyclic Compounds, 1-Ring described as a class of insecticides that are structurally similar to NICOTINE and have physiologically similar effects as agonists of NICOTINIC ACETYLCHOLINE RECEPTORS, but are less toxic to vertebrates. They are widely used in agriculture.", + "output": "Neonicotinoids (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the FPSR questionnaire.", + "output": "FPSR Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Streptococcus viridans group described as a gram-positive organism found in dental plaque, in blood, on heart valves in subacute endocarditis, and infrequently in saliva and throat specimens. L-forms are associated with recurrent aphthous stomatitis.", + "output": "Streptococcus sanguinis corrig. White and Niven 1946 (Approved Lists 1980) emend. Kilian et al. 1989 (Streptococcus sanguinis group)" + }, + { + "input": "Definition: Pharmacologic Substance described as a multi-organ, animal-based dietary supplement used to help strengthen, support and improve the function of the male reproductive system.", + "output": "C.L.F.sxul suprt ma mult-org (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as chaperone Protein Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction by cellular proteins that mediate assembly/disassembly, stabilization, and transmembrane translocation of other polypeptides or complexes, but which are not components of those final structures.", + "output": "Chaperone Protein Interaction (Molecular Function)" + }, + { + "input": "Definition: pseudocleavage described as formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.", + "output": "pseudocleavage involved in syncytial blastoderm formation (Organism Function)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Children's Since Last Visit (C-SSRS Children's Since Last Visit) Most severe ideation.", + "output": "CSS08-Most Severe Ideation (C-SSRS Children's Since Last Visit Questionnaire Question)" + }, + { + "input": "Definition: Disorder of bone and articular cartilage described as osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).", + "output": "Osteoporosis (Bone Diseases)" + }, + { + "input": "Definition: Signaling Protein described as protein sprouty homolog 4 (299 aa, ~33 kDa) is encoded by the human SPRY4 gene. This protein plays a role in the inhibition of receptor-mediated signaling pathways.", + "output": "Spry-4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Bruising, ecchymosis and purpura described as appearance of skin bruises following perceived minimal contact or injury.", + "output": "easy bruisability (Skin, Human)" + }, + { + "input": "Definition: Streptococcal Infections described as group B Streptococcus, also known as Streptococcus agalactiae, colonizes the vaginal and gastrointestinal tracts of up to 45% of healthy women and may infect neonates in utero or during delivery, causing neonatal sepsis in 1-2% of colonized neonates. GBS infection may also occur in nonpregnant (particularly elderly) adults with underlying medical conditions, presenting as urinary tract infection, pneumonia, or soft-tissue infection.", + "output": "STREP GROUP B INFECTION (Disease or Syndrome)" + }, + { + "input": "Definition: Medical & Physical Treatment described as removal of a limb or other appendage or outgrowth of the body.", + "output": "amputation procedure (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a thin band of cells along the medial margin of the posterior gray column and the dorsal gray commissure of the spinal cord; it lies over the thoracic column ( Carpenter-1983 ).", + "output": "posterior cornucommissural nucleus (Nucleus of spinal cord)" + }, + { + "input": "Definition: Baseline Nausea and Vomiting Scale described as a subjective score of 7 on a scale that ranges from 0: No nausea at all to 10: Nausea as bad as it can be.", + "output": "Nausea Score 7 (Baseline Nausea and Vomiting Scale)" + }, + { + "input": "Definition: something described as borg CR10 scale test code.", + "output": "Borg CR10 Scale Questionnaire Test Code (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as a group of individuals that approves, monitors and reviews biomedical research to protect the rights, safety and welfare of the study participants, by providing critical scientific, ethical, and/or regulatory oversight functions.", + "output": "Study Oversight Authority (Professional Organization or Group)" + }, + { + "input": "Definition: something described as a monoclonal antibody directed against the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN6 monoclonal antibody ASP1650 binds to CLDN-6 and may stimulate the immune system to exert both an antibody-dependent cellular cytotoxicity (ADCC) and a complement-dependent cytotoxicity (CDC) mediated immune response against CLDN-6-expressing tumor cells. This may inhibit tumor cell growth. CLDN-6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.", + "output": "ASP 1650 (Pharmacologic Substance)" + }, + { + "input": "Definition: Oral cavity finding described as a lesion as a result of galvanic current in the oral cavity due to the presence of two or more dissimilar metals in dental restorations that are bathed in saliva, or a single metal restoration and two electrolytes, saliva and pulp tissue fluid, thus producing an electrolytic cell and an electric current. When such restorations touch each other, the current may be high enough to irritate the dental pulp and cause sharp pain. The anodic restoration or areas of a restoration are subject to electrolytic corrosion.", + "output": "Galvanic lesion of oral cavity (Oral cavity finding)" + }, + { + "input": "Definition: something described as the spatial arrangement of something as distinct from its substance.", + "output": "shaped (Calculus analysis)" + }, + { + "input": "Definition: something described as emotion Recognition Test (ERT) Number of stimuli defined as portraying happiness.", + "output": "EMO110 (ERT Functional Test Question)" + }, + { + "input": "Definition: sulfotransferase activity described as catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.", + "output": "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity (Molecular Function)" + }, + { + "input": "Definition: Measuring Instruments described as instruments designed to measure the quantity of energy per unit of time (i.e., power), usually in watts. Power meters typically include detectors, electronic circuitry, and displays with characteristics appropriate to measure a particular type of energy (e.g., direct-current, alternating-current, and/or radio-frequency electric power; ultrasonic power) within a range of power values. Power meters are typically used to measure the power output of medical devices (e.g., diathermy units, warmers, ultrasonic physiotherapy units) or to determine the strength of radiation at a given point.", + "output": "Power Meters (Medical Device)" + }, + { + "input": "Definition: something described as the techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.", + "output": "Evolution, Molecular, Directed (Genetic Engineering)" + }, + { + "input": "Definition: Psychology, Educational described as systematic efforts to assist individuals in selecting an occupation or suitable employment on the basis of aptitude, education, etc.", + "output": "Counselling;vocational (Personnel Management & Professional Personnel Issues)" + }, + { + "input": "Definition: something described as a NADP transhydrogenase subtype found in certain types of BACTERIA. This transhydrogenase uses a mechanism that transfers hydrogen to the B side of the NAD(+) or NADP(+) ring structure.", + "output": "Pyridine Nucleotide Transhydrogenase, B Specific (NADP Transhydrogenase)" + }, + { + "input": "Definition: something described as human LINC00598 wild-type allele is located in the vicinity of 13q14.11 and is approximately 457 kb in length. This allele, which encodes long intergenic non-protein coding RNA 598, may play a role in tumorigenesis. A translocation t(12;13)(p13;q14) involving this gene and the ETV6 gene is associated with B-cell acute lymphoblastic leukemia.", + "output": "TTL-T (LINC00598 gene)" + }, + { + "input": "Definition: something described as an ependymal tumor arising from the thoracic region of spinal cord.", + "output": "Thoracic Spinal Cord Ependymal Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Neoplastic Process described as leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.", + "output": "Acute myeloid leukemia (acute myeloid leukemia and related precursor neoplams)" + }, + { + "input": "Definition: regulation of cellular amino acid biosynthetic process described as any process that modulates the frequency, rate or extent of histidine biosynthetic process.", + "output": "regulation of histidine formation (Molecular Function)" + }, + { + "input": "Definition: something described as intrahepatic bile duct cancer with a finding of carcinoma in situ (intraductal tumor).", + "output": "Intrahepatic Bile Duct Cancer pTis TNM Finding v7 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.", + "output": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity (alpha-1,3-mannosyltransferase activity)" + }, + { + "input": "Definition: Sharp instrument described as an orthopedic manual surgical instrument is a nonpowered hand-held device intended for medical purposes to manipulate tissue, or for use with other devices in orthopedic surgery. This generic type of device includes the cerclage applier, awl, bender, drill brace, broach, burr, corkscrew, countersink, pin crimper, wire cutter, prosthesis driver, extractor, file, fork, needle holder, impactor, bending or contouring instrument, compression instrument, passer, socket positioner, probe, femoral neck punch, socket pusher, reamer, rongeur, scissors, screwdriver, bone skid, staple driver, bone screw starter, surgical stripper, tamp, bone tap, trephine, wire twister, and wrench.", + "output": "CUTTER, WIRE (Orthopedic Equipment)" + }, + { + "input": "Definition: something described as the only fungal genus in the Syncephalastraceae family within the Mucorales order. Sporangiospores are produced asexually through the development of cylindrical merosporangia; however, syncephalastrum also undergoes a sexual cycle that produces zygospores. It is primarily isolated from animal excrement, plant material, and soil in tropical or subtropical regions.", + "output": "Syncephalastrum (Fungus)" + }, + { + "input": "Definition: DNA Helicases described as nonEC; ATP-driven topoisomerase which unwinds duplex DNA immediately prior to replication or transcription.", + "output": "Helicases (Enzyme)" + }, + { + "input": "Definition: Unique Identifier described as a unique identifier for a series of DICOM SOP instances.", + "output": "Series Instance UID (Unique Identifier)" + }, + { + "input": "Definition: Inflammation of specific body organs described as inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.", + "output": "epididymitis (Inflammatory disorder of male genital organ)" + }, + { + "input": "Definition: Abnormal auditory perception described as a condition in which a person loses the ability to hear high frequency sounds. It is typically associated with impairment of the inner ear.", + "output": "High-frequency hearing impairment (Diseases of inner ear)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3.", + "output": "monomethylamine:corrinoid methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: regulation of organelle organization described as any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.", + "output": "regulation of vacuole organisation (Cell Function)" + }, + { + "input": "Definition: something described as the set of CDISC data standards (including ODM and LAB) used to capture and archive data from clinical trials.", + "output": "Operational Model (Intellectual Product)" + }, + { + "input": "Definition: Potency Unit described as a dosing measurement based on the box unit.", + "output": "Box (Quantitative Concept)" + }, + { + "input": "Definition: Chromosomes, Human described as a specific pair of GROUP E CHROMOSOMES of the human chromosome classification.", + "output": "Chromosome 17 (NUCLEUS AND ASSOCIATED STRUCTURES)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.", + "output": "SURG CLAMPS (Medical Device)" + }, + { + "input": "Definition: something described as moderate pain; limiting instrumental ADL", + "output": "Grade 2 Oral Pain, CTCAE (Oral Pain, CTCAE 5.0)" + }, + { + "input": "Definition: Naevi, hamartomas and developmental anomalies described as multiple abnormalities with a variable expression consisting mainly of asymmetry of the face, trunk, and extremities; atrophy, telangiectasia, pigmentation disorders, and localized fat deposits in the skin; multiple mucous and perioral papillomas; and skeletal abnormalities involving the extremities. Mild mental deficiency occurs in about 15%.", + "output": "focal dermal hypoplasia syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as c-C motif chemokine 3-like 1 (93 aa, ~10 kDa) is encoded by the human CCL3L1 gene. This protein plays a role in both the inhibition of HIV infection and chemotaxis of lymphocytes and monocytes.", + "output": "CCL3L1 protein, human (beta-Chemokines)" + }, + { + "input": "Definition: stage, chronic lymphocytic leukemia described as risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95.", + "output": "Stage I Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)" + }, + { + "input": "Definition: Penile therapeutic procedures described as surgical removal of part or all of the penis.", + "output": "Amputation of penis NOS (Amputation)" + }, + { + "input": "Definition: Cell described as an undifferentiated cell which can undergo division and can give rise to any of the early stage myeloid cells.", + "output": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation (Cell)" + }, + { + "input": "Definition: Regulatory Protein described as nicastrin (709 aa, ~78 kDa) is encoded by the human NCSTN gene. This protein is involved in the regulation of intramembrane cleavage catalyzed by the gamma-secretase complex.", + "output": "Nicastrin (Biologically Active Substance)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) Initial/first attempt potential lethality.", + "output": "CSS09-First Attempt Potential (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.", + "output": "3-oxopropanoate:NAD(P)+ oxidoreductase (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Mitomycins described as a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1820\" active clinical trials using this agent.", + "output": "chemotherapeutics mitomycin (M [Preparations])" + }, + { + "input": "Definition: Immunologic Factor described as bladder tumor associated antigen is a human complement factor H-related protein (hCFHrp), a glycoprotein produced by cancer cells and macrophages but not by normal epithelia. In cell culture, hCFHrp was shown to be produced by several human bladder cancer cell lines, but not by normal epithelial cell lines. By interaction with complement factor C3b, hCFH serves to inhibit the formation of a membrane attack complex, thereby preventing cell lysis. Production of bladder tumor associated antigen may confer a selective growth advantage to cancer cells in vivo by allowing the cells to evade the host immune system. Approved by FDA as a tumor marker for screening test for transitional cell carcinoma.", + "output": "Bladder Tumor-Associated Antigen (Immunologic Factor)" + }, + { + "input": "Definition: Organic Chemical described as a quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity.", + "output": "bruceanol H (Organic Chemical)" + }, + { + "input": "Definition: CD Antigens described as an interleukin-13 receptor subunit that is closely-related to the INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT. The receptor is found as a monomeric protein and has been considered to be a decoy receptor for interleukin-13 due the fact that it lacks cytoplasmic signaling domains.", + "output": "Interleukin-13 Receptor alpha2 Chain (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Physical Phenomena described as was previously included under PHYSICAL PROPERTIES.", + "output": "Process, Physical (Natural Phenomenon or Process)" + }, + { + "input": "Definition: something described as a cancer finding in the TNM system that is relevant to the diagnosis of cancer.", + "output": "Cancer TNM Finding (Signs and Symptoms)" + }, + { + "input": "Definition: Specimen described as any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products.", + "output": "BIOSPECIMEN (Body Substance)" + }, + { + "input": "Definition: Clinical Drug described as an oral suspension containing diphenydramine hydrochloride, dexamethasone and nystatin, with anithistaminic, antiinflammatory, and antifungal activities. Diphenhydramine hydrochloride/dexamethasone/nystatin magic mouthwash inhibits the cytokine-mediated inflammation and yeast colonization of the oral mucosa associated with chemotherapy and radiation therapy.", + "output": "Diphenhydramine Hydrochloride/Dexamethasone/Nystatin Magic Mouthwash (Clinical Drug)" + }, + { + "input": "Definition: something described as a lipid bilayer enclosing the part of the endoplasmic reticulum that has ribosomes located on the cytoplasmic-facing membrane.", + "output": "Membrane of rough endoplasmic reticulum (Intracellular Membranes)" + }, + { + "input": "Definition: Antibiotic described as the sodium salt form of carumonam, an N-sulfo monocyclic beta-lactam antibiotic derived from sulfazecin. Carumonam has high resistance to beta-lactamases and activity against aerobic gram-negative bacteria. It reaches high urinary concentrations and may be used in the treatment of urinary tract infections.", + "output": "Carumonam Sodium (Antibiotic)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as the phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.", + "output": "1,4,5,6, 8-Pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)- (Amidophosphoribosyltransferase Inhibitor)" + }, + { + "input": "Definition: PDGFRA Gene Mutation described as a molecular genetic abnormality indicating the presence of a mutation in exon 12 of the PDGFRA gene located within 4q11-q13.", + "output": "PDGFR-2 Exon 12 Mutation (PDGFRA Gene Mutation)" + }, + { + "input": "Definition: CPTAC Responses described as additional surgery for the new tumor event was not performed.", + "output": "Additional Surgery for New Tumor Event Absent (Finding)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as trichinella spiralis serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Trichinella spiralis in serum. The identification aids in the diagnosis of trichinosis caused by parasitic roundworms belonging to the genus Trichinella and provides epidemiological information on trichinosis. Trichinosis is caused by ingestion of undercooked, infested meat, especially pork, and characterized by fever, muscle weakness, and diarrhea.", + "output": "ANTIGEN, BENTONITE FLOCCULATION, TRICHINELLA SPIRALIS (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Oils, Volatile described as linden blossom.", + "output": "Tilia vulgaris (Oils, Volatile)" + }, + { + "input": "Definition: something described as negative elongation factor A (528 aa, ~57 kDa) is encoded by the human NELFA gene. This protein plays a role in transcriptional pausing.", + "output": "NELFA (Biologically Active Substance)" + }, + { + "input": "Definition: regulation of ossification described as any process that modulates the frequency, rate or extent of osteoblast differentiation.", + "output": "regulation of osteoblast differentiation (regulation of cell differentiation)" + }, + { + "input": "Definition: Cell Function described as a process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere.", + "output": "maintenance of granzyme B localization in T cell secretory granule (Cell Function)" + }, + { + "input": "Definition: Social Behavior described as an attitude that is accepting or tolerant of behaviors that may disregard traditional social mores.", + "output": "Permissivenesses (Individual Behavior)" + }, + { + "input": "Definition: something described as the smooth muscle tissue present in the tunica media which is the middle layer of the wall of the arterial system.", + "output": "Arterial System Smooth Muscle Tissue (Tunica Media)" + }, + { + "input": "Definition: Propionates described as salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.", + "output": "lactates (Propionates)" + }, + { + "input": "Definition: Injection procedure described as infusing a substance(s) into a client/patient through the pleura using the force of gravity. Service is billed per infusion.", + "output": "Intrapleural infusion each infusion (Injection procedure)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder of the skin characterized by loss or reduction of the skin color. It is caused by loss of melanocytes or abnormalities in melanin production.", + "output": "disorder pigmentation skin (SKIN, NAILS, HAIR)" + }, + { + "input": "Definition: Abdominal bloating described as distention of the abdomen associated with a feeling of fullness.", + "output": "ABDOMEN BLOATING (Flatulence, eructation, and gas pain)" + }, + { + "input": "Definition: Chromosome 17 Physical Location described as physical location of NOS2A_Gene", + "output": "17: 23151682-23107920 (Spatial Concept)" + }, + { + "input": "Definition: epinephrine described as sympathomimetic, vasoconstrictor agent.", + "output": "Deoxyepinephrine (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.", + "output": "small molecular sensor activity (molecular function)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual is or was uncomfortable in certain positions.", + "output": "Uncomfortable in Certain Positions (Intellectual Product)" + }, + { + "input": "Definition: Descriptors described as a description about the firmness or make-up of an entity.", + "output": "Consistencies (Qualitative Concept)" + }, + { + "input": "Definition: acetate described as an anabolic steroid used mainly as an anabolic agent in veterinary practice.", + "output": "Trenbolone acetate (Estrenes)" + }, + { + "input": "Definition: something described as specifies the link between a study site and a version of the study protocol used or available for use at that site.", + "output": "StudySiteProtocolVersionRelationship (Relationships)" + }, + { + "input": "Definition: Cytokine Measurement described as a measurement of the interleukin 28 in a biological specimen.", + "output": "Interleukin 28 Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Immunologic Factor described as a proprietary conjugate of rituximab, a recombinant chimeric murine/human antibody directed against the CD20 antigen, with potential antineoplastic activity. Upon administration of the rituximab conjugate CON-4619, the rituximab moiety targets and binds to CD20, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells.", + "output": "rituximab conjugate CON-4619 (Anti-CD20 Monoclonal Antibody)" + }, + { + "input": "Definition: something described as a functional anomaly of the mouth (which is also known as the oral cavity). []", + "output": "Abnormal oral physiology (Mouth Abnormalities)" + }, + { + "input": "Definition: Finding described as a necrotizing enterocolitis adverse event in a newborn which results in death.", + "output": "Grade 5 Necrotizing Enterocolitis, Adverse Event (Necrotizing Enterocolitis, Adverse Event)" + }, + { + "input": "Definition: Medical Device described as reagents consisting of substances of known concentrations intended for quality control in a diverse range of sensitive and specific radioimmunoassay tests. Reagents used for radioimmunoassay quality control may be specific for a substance or, more frequently, appropriate for quality control for a whole set of similar substances (e.g., proteins, lipids) that are found in human specimens.", + "output": "IVD Test Reagent/Kits, Immunoassay, Control, Radioimmunoassay (IVD Test Reagent/Kits, Immunoassay, Control)" + }, + { + "input": "Definition: something described as this gene is involved in mitochondrial RNA translation.", + "output": "MRPL45 (Ribosome Subunit Gene)" + }, + { + "input": "Definition: something described as absence or underdevelopment of the tarsal bones.", + "output": "Aplastic/hypoplastic tarsals (Abnormality of the tarsal bones)" + }, + { + "input": "Definition: Functional Concept described as an activity defined at a global library level that is an action of processing a material.", + "output": "Defined Material Process Step (Functional Concept)" + }, + { + "input": "Definition: Pituitary Gland described as the intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).", + "output": "intermediate lobe (Pituitary Gland)" + }, + { + "input": "Definition: something described as non-inflatable extremity splint; see product code FYH.", + "output": "SPLINT, EXTERMITY, NON-INFLATABLE, EXTERNAL, NON-STERILE (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 - Comments From Others: Other people have told me I seemed to have trouble remembering information.", + "output": "FAC07521 (Intellectual Product)" + }, + { + "input": "Definition: Diagnostic Procedure described as obtaining material for pathological examination and analysis, from bodily fluids. Material retrieved includes CELL-FREE NUCLEIC ACIDS; CELL-DERIVED MICROPARTICLES; EXOSOMES; CIRCULATING NEOPLASM CELLS; and other circulating cells and CELLULAR STRUCTURES.", + "output": "Biopsy, Liquid (Biopsy)" + }, + { + "input": "Definition: Chromosomes, Human, 13-15 described as the designation for each member of the fifteenth largest human autosomal chromosome pair. Chromosome 15 spans about 106 million base pairs and represents between 3 and 3.5% of the total DNA in normal diploid cells.", + "output": "chromosome 15 (Chromosomes, Human, 13-15)" + }, + { + "input": "Definition: Ligase described as long-chain-fatty-acid-CoA ligase 6 (697 aa, ~78 kDa) is encoded by the human ACSL6 gene. This protein is involved in fatty acid acylation.", + "output": "FACL6 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Finding described as psychospiritual ease related to self-concept, emotional well-being, source of inspiration, and meaning and purpose in one's life", + "output": "Comfort Status: Psychospiritual (health & life quality)" + }, + { + "input": "Definition: Disease Qualifier described as a term referring to the lack of definitive clinical or pathologic criteria for a tumor to predict its clinical course or classify it as benign or malignant.", + "output": "Undetermined (Findings values)" + }, + { + "input": "Definition: Right bundle branch block with left bundle branch block described as abnormal conduction in all three divisions of the intraventricular conducting tissue.", + "output": "Trifascicular Bundle Branch Block (Conduction disorder of the heart)" + }, + { + "input": "Definition: Health Services described as delivery of health or mental health services over a prolonged or extended period. Care can be in an institutional setting or in the community, e.g., at home, and delivered by health care professionals, family, or friends.", + "output": "Long-Term Care (Aftercare)" + }, + { + "input": "Definition: Organism Attribute described as a relative measurement (ratio) of the waist circumference to the hip circumference.", + "output": "Waist to hip ratio (Personal Attribute)" + }, + { + "input": "Definition: something described as a condition in which there is hypotension because of inadequate pumping function of the heart.", + "output": "Hypotension due to cardiac dysfunction (Hypotension)" + }, + { + "input": "Definition: Molecular Function described as the aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.", + "output": "MHC protein complex assembly (Molecular Function)" + }, + { + "input": "Definition: Sacral Movement Axis described as a hypothetical functional axis from the superior area of a sacroiliac articulation to the contralateral inferior sacroiliac articulation. It is designated as right or left relevant to its superior point of origin. 2. A term described by Fred Mitchell, Sr, DO.", + "output": "Oblique Axis (Anatomical reference line)" + }, + { + "input": "Definition: something described as the process by which the form or structure of an organism or a bioactive molecule is modified to survive or have activity in a low temperature environment.", + "output": "Cold Adaptation (Physical Phenomenon or Property)" + }, + { + "input": "Definition: something described as a nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules.", + "output": "nuclear membrane microtubule tethering complex location (Cell Component)" + }, + { + "input": "Definition: Poisons described as poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.", + "output": "Venom (Pharmaceutical Preparations)" + }, + { + "input": "Definition: Menstrual cycle described as menstruation", + "output": "Menstrual period (Symptom severity level: perimenopause)" + }, + { + "input": "Definition: Intellectual Product described as the classification of systemic lupus erythematosus based on eleven criteria. Intended to be used as inclusion criteria for clinical studies, a person is defined as having systemic lupus erythematosus if any four or more of the eleven criteria are present, serially or simultaneously, during any interval of observation.", + "output": "ACR Classification Criteria for SLE (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as a subdivision of the thalamus. It, the Nucleus dorsooralis externus (Hassler) and the Nucleus dorsooralis internus (Hassler) constitute the parvicellular part of the ventral anterior nucleus ( Macchi-1997 ).", + "output": "Nucleus dorsooralis internus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as human IGF2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 15 kb in length. This allele, which encodes insulin-like growth factor II protein, plays a role in cellular growth, development, and mitogenesis.", + "output": "Chromosome 11 Open Reading Frame 43 Gene (IGF2 gene)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.", + "output": "transposase activity (catalytic activity, acting on DNA)" + }, + { + "input": "Definition: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains described as any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.", + "output": "upregulation of T-helper 1 type immune response (regulation of T-helper 1 type immune response)" + }, + { + "input": "Definition: Congenital anomaly of esophagus described as congenital tracheoesophageal fistula without esophageal atresia.", + "output": "H-type congenital tracheesophageal fistula (Congenital esophagotracheal fistula)" + }, + { + "input": "Definition: Potency Unit described as the amount of a substance required to achieve a specified, measurable physiological change in a controlled environment.", + "output": "CLINICAL UNITS (Potency Unit)" + }, + { + "input": "Definition: Locally Advanced Carcinoma described as digestive system carcinoma that has spread to nearby tissues or lymph nodes.", + "output": "Locally Advanced Digestive System Carcinoma (Metastatic Digestive System Carcinoma)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an adenosine triphosphate release assay is a device that measures the release of adenosine triphosphate (ATP) from platelets following aggregation. This measurement is made on platelet-rich plasma using a photometer and a luminescent firefly extract. Simultaneous measurements of platelet aggregation and ATP release are used to evaluate platelet function disorders.", + "output": "ADENINE NUCLEOTIDE QUANTITATION (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Very advanced local disease. Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures. N3: Tumor with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE(+). M0: No distant metastasis.", + "output": "Stage IVB Hypopharyngeal Carcinoma AJCC v8 (Stage IVB Pharyngeal Carcinoma)" + }, + { + "input": "Definition: Instrument - device described as a proprietary high-throughput chemiluminescent immunoassay system manufactured by Siemens.", + "output": "ADVIA Centaur (Manufactured Object)" + }, + { + "input": "Definition: something described as serology reagents used in tests intended to detect antigens that permit the identification of strains of Legionella pneumophila bacteria. These bacteria cause a pneumonia-like disease in humans (legionellosis).", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species, Antigen (IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species)" + }, + { + "input": "Definition: Immune system excision described as surgical excision of one or more lymph nodes. Its most common use is in cancer surgery.", + "output": "Lymph Nodes: Excision (Procedure on lymph node)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) Because of your health condition, in the past 30 days how much difficulty did you have in: Getting your work done as quickly as needed?", + "output": "WD5D5 8 (Intellectual Product)" + }, + { + "input": "Definition: racemase and epimerase activity, acting on carbohydrates and derivatives described as catalysis of the reaction: alpha-maltose = beta-maltose.", + "output": "maltose 1-epimerase activity (Molecular Function)" + }, + { + "input": "Definition: Blinded Clinical Study described as a study method in which neither the subjects nor the investigators are permitted to know which subject is receiving which treatment.", + "output": "double-blind studies (Research Design)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.", + "output": "STAT Transcription Factors (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Ocular infections, inflammations and associated manifestations described as infection caused by the protozoan parasite Toxoplasma in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear; chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis; the severe ocular lesions in infants may lead to blindness.", + "output": "Ocular toxoplasmosis (Toxoplasmosis)" + }, + { + "input": "Definition: something described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.", + "output": "bones hooks (Surgical Hooks)" + }, + { + "input": "Definition: Virus described as a species of PARAPOXVIRUS causing a pox-like disease on udders of cows that may spread to milkers.", + "output": "Virus, Paravaccinia (Pox Viruses Subgenus B)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant hemangiopericytoma occurring in childhood. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8090\" active clinical trials using this agent.", + "output": "malignant hemangiopericytoma, childhood (cellular diagnosis, childhood soft tissue sarcoma)" + }, + { + "input": "Definition: Organic Chemical described as an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.", + "output": "Streptomycin (antibiotics, intestinal)" + }, + { + "input": "Definition: something described as an autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of factor VII activity in the blood.", + "output": "Hereditary hypoproconvertinaemia (Disease or Syndrome)" + }, + { + "input": "Definition: Nose described as chronic rhinitis accompanied by pus formation. []", + "output": "Purulent nasal discharge (Rhinitis)" + }, + { + "input": "Definition: Pharmacologic Substance described as a controlled-release, intratumoral paclitaxel formulation in which paclitaxel is incorporated into a thermosensitive, biodegradable triblock copolymer consisting of poly(lactide-co-glycolide) (PLGA) and polyethylene glycol (PEG). Upon intratumoral injection, paclitaxel is released slowly and continuously into tumor tissues from the gelled thermosensitive triblock copolymer over a period of 4 to 6 weeks; in tumor cells, paclitaxel binds to tubulin and inhibits the disassembly-assembly dynamics of microtubules, resulting in cell cycle arrest and cell death. The thermosensitive triblock copolymer component of this formulation transforms from a water-soluble polymer at room temperature to a water-insoluble, biodegradable gel depot at body temperature; intratumoral controlled-release of paclitaxel from the gel minimizes systemic exposure to paclitaxel and the paclitaxel toxicity profile. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71692\" active clinical trials using this agent.", + "output": "PGLA/PEG copolymer-based paclitaxel (paclitaxel)" + }, + { + "input": "Definition: Delivery finding described as a measured weight of a newborn obtained immediately or shortly after birth.", + "output": "Birth weight finding (Body weight characteristic)" + }, + { + "input": "Definition: something described as a non-invasive, papillary epithelial neoplasm that arises from the epithelium of the extrahepatic bile ducts.", + "output": "papillomatosis of extrahepatic bile duct (Neoplastic Process)" + }, + { + "input": "Definition: something described as the Expanded Prostate Cancer Index Composite Short Form - Overall, how big a problem has your sexual function or lack of sexual function been for you during the last 4 weeks?", + "output": "EPIC1-Overall Problem Sexual Function (EPIC-26 Questionnaire Question)" + }, + { + "input": "Definition: Cell Component described as a ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins.", + "output": "U11/U12 snRNP (spliceosomal snRNP complex)" + }, + { + "input": "Definition: Alkylsulfonate Compound described as an alkyl sulfonate with potential antineoplastic activity. Piposulfan alkylates DNA, thereby producing DNA interstrand crosslinks and DNA strand breaks and inhibiting DNA replication. This agent has been shown to exhibit antitumor activity in an animal model of prostate cancer.", + "output": "PIPOSULFAN (Alkylsulfonate Compound)" + }, + { + "input": "Definition: something described as prepackaged collections of the devices and supplies (either custom or standard kits) needed for visualizing the arteries during special radiography procedures (i.e., special procedure angiography). Items in these kits usually include drapes, gowns, plastic syringes, connecting tubing, gauge needles, scalpels, gauze, towels and bowls; kits may also include a povidone-iodine packet, swab sticks and puncture site bandages. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Special procedure angiography procedure kits and trays are intended for use during interventions such as stent placements, discography, placement of permanent vascular access ports and peripherally inserted central catheters (PICCs), and placement of devices/grafts for dialysis access.", + "output": "Procedure Kit/Trays, Angiography, Special Procedure (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as a benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C37899\" active clinical trials using this agent.", + "output": "((4E,6E,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate (Organic Chemical)" + }, + { + "input": "Definition: Neoplastic Process described as stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: \"flat tumor\". N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage 0 Transitional Cell Carcinoma of Urinary Bladder (Malignant neoplasm of urinary bladder)" + }, + { + "input": "Definition: Intraocular melanoma, non-spindle cell described as a uveal melanoma characterized by the presence of tumor cell necrosis.", + "output": "necrotic intraocular melanoma (Neoplastic Process)" + }, + { + "input": "Definition: Finding described as an abnormality of the function of the inner ear.", + "output": "Functional abnormality of the inner ear (Abnormality of the inner ear)" + }, + { + "input": "Definition: Streptococcus pneumoniae IgG Antibody Measurement described as the determination of the amount of Streptococcus pneumoniae serotype 22F IgG antibody present in a sample.", + "output": "S. pneumonia Sero 22F IgG AB (Streptococcus pneumoniae IgG Antibody Measurement)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the UNC13D gene.", + "output": "FHL3 Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Finding described as an increased concentration of dicarboxylic acid in the urine.", + "output": "Dicarboxylic aciduria (Finding)" + }, + { + "input": "Definition: something described as diacylglycerol kinase eta (1220 aa, ~135 kDa) is encoded by the human DGKH gene. This protein plays a role in the phosphorylation of diacylglycerol.", + "output": "Diacylglycerol Kinase Eta, human (Enzyme)" + }, + { + "input": "Definition: something described as JFK Coma Recovery Scale-Revised - Communication scale.", + "output": "CRS-R - Communication Scale (CRS-R Clinical Classification Question)" + }, + { + "input": "Definition: Quantitative Concept described as a measure of volume concentration expressed as the number of milliters of a dissolved substance per deciliter of solution.", + "output": "mls/dl (Unit of Volume Fraction)" + }, + { + "input": "Definition: Immunologic Factor described as a fully human, second-generation, nonfucosylated monoclonal antibody directed against the cell surface receptor CD30 with potential immunomodulating and antineoplastic activities. Anti-CD30 monoclonal antibody MDX-1401 specifically binds to the CD30 antigen, which may result in a cytotoxic T lymphocyte (CTL) response against CD30-expressing tumor cells. CD30, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on activated lymphocytes transiently and is constitutively expressed in hematologic malignancies including Hodgkin's disease and some T-cell non-Hodgkin's lymphomas. Compared to conventional antibodies, deletion of fucose molecules on the antibody backbone, as is done in MDX-1401, may result in an increased affinity for Fc receptors and an enhanced antibody-dependent cellular cytotoxicity (ADCC). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77886\" active clinical trials using this agent.", + "output": "anti-CD30 monoclonal antibody MDX-1401 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as double-bladder cuffs intended for reuse including two inflatable bladders and a contoured cuff that has a smaller diameter distally than proximally when wrapped; the cuffs are designed to exert a pressure on the circumference of an extremity by means of a compressed gas delivered by a pneumatic tourniquet. These devices usually include two bladders within the cuff that are inflated through tubes (e.g., hoses) that run from the bladder connectors to the source of compressed air located in the control unit of the tourniquet. The cuff is fastened to the extremity using contact mechanisms (e.g., clips) and frequently secured with an external ribbon. Contoured cuffs have an arced design to give them the smaller distal diameter when wrapped; some cuffs include pivoting fastening straps to allow adjustment of both distal and proximal diameters to suit the limb providing also more comfort to patients. They are used mainly during surgical procedures in the extremities using general anesthesia. Reusable contoured double-bladder cuffs are intended for use in specific extremity areas (e.g., arm, thigh) are available.", + "output": "Cuffs, Pneumatic Tourniquet, Double Bladder, Contoured, Reusable (Medical Device)" + }, + { + "input": "Definition: Biologically Active Substance described as a substance made by cells that stimulates new blood vessel formation.", + "output": "VEGF-A protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as an individual biologic entity connected/linked to another biologic entity. EXAMPLE(S): family member, roommate, nursing home attendant OTHER NAME(S): NOTE(S):", + "output": "Associated Biologic Entity (Entity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a group of nerve cells in the midline of the thalamus ( Crosby-1962 ).", + "output": "Nucleus interanteroventralis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Pseudomonas otitidis.", + "output": "PSEUDOMONAS OTITIDIS (Pseudomonas)" + }, + { + "input": "Definition: Nerve Sheath Tumors described as a tumor that arises in nerve cells.", + "output": "NEUROMA (Benign Neoplasm)" + }, + { + "input": "Definition: Adverse Event by Type described as any adverse event associated with a medical product or procedure that has not been previously observed, whether or not the event was anticipated because of the pharmacologic properties of the study agent or the nature of the medical procedure. This includes events that are more serious than expected or occur more frequently than expected, particularly, any adverse experience, the nature, severity or frequency of which is not consistent with the product label, or with the current investigator brochure for investigational agent; or with the risk information described in the investigational plan or protocol or consent form.", + "output": "unexpected adverse event (Adverse Event by Type)" + }, + { + "input": "Definition: Heart described as a thin, crescent-shaped fold of the endocardium at the orifice of the coronary sinus into the right atrium.", + "output": "Coronary valve (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: regulation of receptor localization to synapse described as any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.", + "output": "regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane (regulation of receptor localization to synapse)" + }, + { + "input": "Definition: Type of drug preparation described as an intimate mixture of dry, finely divided drugs and/or chemicals that may be intended for internal or external use.", + "output": "Drug powder (Biomedical or Dental Material)" + }, + { + "input": "Definition: Laboratory or Test Result described as an indication that expression of CD86 has been detected in a sample.", + "output": "B7.2 Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: Pathologic Function described as muscular atrophy involving the quadriceps muscle.", + "output": "Wasting of quad muscles (Proximal lower limb amyotrophy)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of medical record that provided the best information when abstracting the relevant healthcare data. EXAMPLE(S): 1 = Hospital inpatient; Managed health plans with comprehensive, unified medical records (new code definition effective with diagnosis on or after 1/1/2006) 2 = Radiation Treatment Centers or Medical Oncology Centers (hospital affiliated or independent) (effective with diagnosis on or after 1/1/2006) 3 = Laboratory Only (hospital affiliated or independent) 4 = Physician's Office/Private Medical Practitioner (LMD) 5 = Nursing/Convalescent Home / Hospice 6 = Autopsy Only 7 = Death Certificate Only 8 = Other hospital outpatient units/surgery centers (effective with diagnosis on or after 1/1/2006) OTHER NAME(S): Type of Reporting Source (NCI SEER) NOTE(S): This is not necessarily the original document that identified the case; rather, it is the source that provided the best information.", + "output": "PerformedMedicalRecordAbstraction.reportingSourceTypeCode (Reporting Source Type Code)" + }, + { + "input": "Definition: Dietary Supplements described as fluorine ion requiring removal of one electron to return to its elemental state.", + "output": "Fluoride product (Anions)" + }, + { + "input": "Definition: Anti-Infective Agents described as group of antibiotics containing beta lactam rings which are cleaved by the beta lactamases produced by almost all gram negative bacteria.", + "output": "Monobactams (Lactams)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid.", + "output": "L-galactonate catabolism (L-galactonate metabolic process)" + }, + { + "input": "Definition: Fertilization described as movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.", + "output": "Motilities, Sperm (Male reproductive function)" + }, + { + "input": "Definition: something described as a developmental deformity in which the metaphysis of the FEMUR moves proximally and anteriorly away from FEMUR HEAD (epiphysis) at the upper GROWTH PLATE. It is most common in male adolescents and is associated with a greater risk of early OSTEOARTHRITIS of the hip.", + "output": "SCFE (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.", + "output": "Ascending aortic dissection (Abnormal ascending aorta morphology)" + }, + { + "input": "Definition: something described as something submitted for the judgment or consideration of others.", + "output": "Submission (Document type)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as olfactory bulb which is continuous with the right set of olfactory nerves and the right olfactory tract.", + "output": "Right olfactory bulb (Structure of olfactory bulb)" + }, + { + "input": "Definition: Finding described as lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.", + "output": "Lung Cancer pT1a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Hereditary disturbances in tooth structure described as a congenital tooth development disorder caused by mutations in the DSPP gene. The teeth are weak, discolored, and translucent.", + "output": "Imperfecta, Dentinogenesis (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Immunoproliferative morphology described as an angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells. Incidence is higher among adult males; patients with a history of immunodeficiency are at increased risk. The most common site of involvement is the lung; other common sites include brain, kidney, liver, and skin. Morphologically, three grades are recognized: grade I, II, and III. Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.", + "output": "Granulomatoses, Lymphomatoid (Viral cardiovascular infection)" + }, + { + "input": "Definition: Biologic Function described as the process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure.", + "output": "shoot apical meristem development (Biologic Function)" + }, + { + "input": "Definition: something described as a chromosome band present on 8q", + "output": "8q22.3-q23 (Cell Component)" + }, + { + "input": "Definition: something described as any neuron projection extension that is involved in neuron projection guidance.", + "output": "neuron projection extension involved in neuron projection guidance (neuron projection extension)" + }, + { + "input": "Definition: Health Care Related Organization described as the Translational Research Shared Resource supports Cancer Center clinical trials by providing infrastructure for laboratory correlate studies. The resource collects, tracks, processes and distributes samples to collaborating laboratories and shared resources, maintains database on samples information, and acts as a resource for investigators during protocol planning by providing information about all aspects of specimen handling.", + "output": "Translational Research Shared Resource (Clinical or Research Facility)" + }, + { + "input": "Definition: Homeopathic remedies letter B described as borate of sodium.", + "output": "Borax / sodium borate (Homeopathic remedies letter B)" + }, + { + "input": "Definition: something described as solid single-dose preparation consisting of a tablet coated with one or more layers of mixtures of various substances such as sugars and waxes. To the coating colouring matter, flavouring substances and active substance(s) may be added. The thickness of the coating is greater than that of a film-coated tablet. Coated tablets have a smooth surface. They are intended for oral use. When the coating dissolves or disintegrates the active substance(s) is (are) released into the gastrointestinal fluid at a rate depending essentially on its intrinsic properties (conventional release).", + "output": "coated tablet (Biomedical or Dental Material)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the ratio of monoclonal protein spike compared to total protein present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "MSPIKEPT (Laboratory Procedure)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+).", + "output": "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)" + }, + { + "input": "Definition: Esophagus and Esophagogastric Junction Cancer Pathologic Regional Lymph Nodes TNM Finding v8 described as esophagus and esophagogastric junction cancer with metastasis in seven or more regional lymph nodes.", + "output": "Esophagus and Esophagogastric Junction Cancer (Squamous Cell Carcinoma and Adenocarcinoma) pN3 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Coronary vasodialator described as a carboline derivative and PHOSPHODIESTERASE 5 INHIBITOR that is used primarily to treat ERECTILE DYSFUNCTION; BENIGN PROSTATIC HYPERPLASIA and PRIMARY PULMONARY HYPERTENSION.", + "output": "tadalafil (Phosphodiesterase 5 inhibitor)" + }, + { + "input": "Definition: Pharmacologic Substance described as hormones made from cholesterol and protein produced by the adrenal glands and regulate electrolyte balance, blood pressure, inflammation, blood sugar balance, and immune system control.", + "output": "Adrenal hormone, NOS (Adrenal hormone preparation)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity.", + "output": "ribonucleinicum acidum/ribon (Biological macromolecule)" + }, + { + "input": "Definition: Pharmacologic Substance described as tobacco.", + "output": "Nicotania tabacum (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as symptomatic, invasive intervention not indicated", + "output": "Grade 2 Pharynx GI fistula (Finding)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Proxy-administered (WHODAS 2.0 36-item Version Proxy-administered) In the past 30 days, not counting the days that your relative was totally unable, for how many days did your relative cut back or reduce his or her usual activities or work because of any health condition?", + "output": "WHODAS 2.0 36-item Version Proxy-administered - How Many Days Reduce Activities (Intellectual Product)" + }, + { + "input": "Definition: apoptotic mitochondrial changes described as any regulation of mitochondrial membrane permeability that is involved in apoptotic process.", + "output": "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis (regulation of mitochondrial membrane permeability)" + }, + { + "input": "Definition: MMP10 gene described as human MMP10 wild-type allele is located in the vicinity of 11q22.3 and is approximately 10 kb in length. This allele, which encodes stromelysin-2 protein, is involved in proteolysis of components of the extracellular matrix.", + "output": "MMP10 wt Allele (MMP10 gene)" + }, + { + "input": "Definition: Heligmosomatoidea described as a genus of nematodes found mainly in mice. Its organisms are used in biomedical research.", + "output": "Nematospiroides (Heligmosomatoidea)" + }, + { + "input": "Definition: Dog family described as a small spaniel with a short, broad face, and a soft, feathered coat. A thick ruff covers the neck and chest. The nose is wide and the nostrils open. The upside-down, v-shaped ears are well covered with hair. The coat may be white with colored patches, most often black, but is sometimes red, yellow, orange, sable, or brindle. The average height range is 7-11 inches and the weight is up to 9 pounds.", + "output": "Japanese chin dog (Toy Breed)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of ibrutinib that may be used in the treatment of mantle cell lymphoma, Waldenstrom's macroglobulinemia (WM), lymphoplasmacytic lymphoma (LPL), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL).", + "output": "Ibrutinib Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Spinal cord, roots and ganglia structure described as an area of grey matter containing motor neurons that projects anteriorly from either side of the center of the spinal cord.", + "output": "ventral gray column (Spinal cord, roots and ganglia structure)" + }, + { + "input": "Definition: something described as an X-linked form of Charcot-Marie-Tooth syndrome (sensory and motor neuropathy with atrophy of the peroneal muscle advancing to involve other distal muscles of the leg and arm) associated with deafness and mental retardation and onset in infancy with distal weakness and sensory loss in late childhood or adolescence leading to moderate disability in adulthood.", + "output": "Cowchock syndrome (X-linked hereditary motor and sensory neuropathy)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 13q", + "output": "13q14-q21 (Cell Component)" + }, + { + "input": "Definition: Finding described as a persons ability to walk between locations in a room.", + "output": "Ability to walk in room (Finding)" + }, + { + "input": "Definition: something described as any intervention or procedure performed by a caregiver during the course of their duties.", + "output": "caregiver-related intervention or procedure (Health Care Activity)" + }, + { + "input": "Definition: Asians described as a person having origins in any of the original peoples of the South Asia.", + "output": "South Asian (Population Group)" + }, + { + "input": "Definition: View box described as view boxes designed for visual examination of a process and/or its results using ultraviolet (UV) light. These view boxes typically include UV lamps of one or more frequencies (254, 312, and 366 nm are typical), a translucent diffusing screen, and filters. UV view boxes are used mainly in clinical laboratories for visual examination of a process and/or its results (e.g., for assessing thin layer chromatographs, electrophoresis gels); they are also used in photo documentation processes that include a photographic camera with appropriate filters and adapters.", + "output": "View Boxes, Ultraviolet (Medical Device)" + }, + { + "input": "Definition: Enterococcus described as any bacterial organism that can be assigned to the species Tetragenococcus solitarius.", + "output": "Tetragenococcus solitarius (Bacterium)" + }, + { + "input": "Definition: Pyrimidines described as pyrimidine bases attached to a ribose or deoxyribose.", + "output": "Pyrimidine Nucleosides (Nucleosides)" + }, + { + "input": "Definition: something described as any substance or agent which suppresses, prevents or opposes the action of the hydrolase class of enzymes that are phosphoric monoester hydrolases which catalyzing the release of inorganic phosphate from phosphoric esters.", + "output": "phosphatase inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: Medical Device described as scissors designed to cut and excise foreign material and/or damaged or contaminated tissue from or around a wound. These scissors are typically handheld, manual instruments with two metallic (e.g., stainless steel) sharp or serrated blades with fine tips that slide past each other (i.e., shearing action). The blades are attached to long, straight, or curved shanks finished in handles at the proximal end conformed as a ring to facilitate holding and operating with the fingers; both parts are joined by a swivel pin in the center.", + "output": "Scissors, Wound Debridement (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as chronic, progressive, debilitating and non-reversible fibrosis of the submucosal tissues of the mouth. It is associated with chewing betel quid, a habit practiced in Southeast Asia and India. It is a precancerous condition and results in rigidity of the jaws and inability of the affected individual to open the mouth.", + "output": "Oral submucous fibrosis, incl of tongue (Oral Cavity and Lip Precancerous Condition)" + }, + { + "input": "Definition: Perfusion finding described as lack of blood supply to a part of the body. Ischemia may cause tissue damage due to the lack of oxygen and nutrients.", + "output": "Ischemias (Pathologic Processes)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 12 + 24-Item Interviewer - In the past 30 days: How much has your health been a drain on the financial resources of you or your family?", + "output": "WHODAS 2.0 12+24-item Version Interviewer-administered - Drain on Financial Resources (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of homoserine biosynthetic process.", + "output": "regulation of homoserine biosynthesis (regulation of cellular amino acid biosynthetic process)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a nitrogen (amino-nitrogen) test system is a device intended to measure amino acid nitrogen levels in serum, plasma, and urine. Nitrogen (amino-nitrogen) measurements are used in the diagnosis and treatment of certain forms of severe liver disease and renal disorders.", + "output": "NINHYDRIN, NITROGEN (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as barnes Akathisia Rating Scale (BARS) Global clinical assessment of akathisia.", + "output": "BARS0104 (BARS Questionnaire Question)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as administering prescribed intravenous fluids rapidly", + "output": "Rapid intravenous fluid resuscitation each infusion (Intravenous infusion procedures)" + }, + { + "input": "Definition: something described as a device designed to monitor a specific function of a system.", + "output": "Function Indicator Device (Manufactured Object)" + }, + { + "input": "Definition: Corynebacterium described as a species of gram-positive, asporogenous bacteria that was originally isolated from necrotic areas in the kidney of a sheep. It may cause ulcerative lymphangitis, abscesses, and other chronic purulent infections in sheep, horses, and other warm-blooded animals. Human disease may form from contact with infected animals.", + "output": "CORYNEBACTERIUM PSEUDOTUBERCULOSIS (Bacterium)" + }, + { + "input": "Definition: Nematodes described as a genus of trichuroid nematodes parasitic in the liver and intestines of many mammals and birds. Two species, C. hepatica and C. philippinensis, produce often fatal infections in man.", + "output": "Capillaria, NOS (Nematodes)" + }, + { + "input": "Definition: Plant described as a plant genus of the family MARANTACEAE that is the source of arrowroot starch.", + "output": "Arrowroots (Marantaceae)" + }, + { + "input": "Definition: Organism Function described as cardiopulmonary mechanisms that support activity/rest", + "output": "Cardiovascular/pulmonary responses (Activity/rest)" + }, + { + "input": "Definition: Medical Device described as thoracic-lumbosacral spine orthoses designed for maximum restriction of movements and/or total immobilization (i.e., motion control) of the thoracic, lumbar, and sacral segments of the spine. They may restrict spine segment movements (flexion and/or extension) in one or more of the sagittal, coronal, and/or transverse planes. These orthoses usually consist of rigid (custom-made and prefabricated orthoses are available) structures typically made of malleable radiolucent aluminum alloys in a variety of shapes and sizes. The orthoses usually include thoracic and/or inter-scapular bands and paraspinal and/or lateral bars. Immobilizer thoracic-lumbosacral orthoses are intended for long-term care of spinal deformities and for rehabilitation after trauma. Dedicated orthoses for movement control in the sagittal (e.g., Taylor), sagittal/coronal (e.g., Knight-Taylor) planes and triplanar control are available.", + "output": "Thoracic-Lumbosacral Immobilizers (Orthoses, Spine, Thoracic-Lumbosacral)" + }, + { + "input": "Definition: Feeding and dietary regimes described as providing and promoting a balanced intake of nutrients", + "output": "nutrition management (Nutrition Therapy)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O.", + "output": "pipecolic acid N-hydroxylase (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of the prostaglandin D2 synthase in a sample.", + "output": "Prostaglandin D2 Synthase Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: something described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to Parainfluenza type 3 virus, a single-stranded RNA virus of the genus Paramyxovirus, family Paramyxoviridae. This virus is an etiologic agent of parainfluenza and several upper respiratory tract infections (e.g., bronchitis, pneumonia) of varying severity.", + "output": "IVD Test Reagent/Kits, Serology, Virus, Parainfluenza 3, IgG Antibody (IVD Test Reagent/Kits, Serology, Virus, Parainfluenza, Antibody)" + }, + { + "input": "Definition: Biologically Active Substance described as acrosin-binding protein (543 aa, ~61 kDa) is encoded by the human ACRBP gene. This protein plays a role in sperm capacitation.", + "output": "Cancer/Testis Antigen 23 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Anastomosis of artery with bypass graft described as surgical creation of a connection between an artery and a vein, often done for the purpose of hemodialysis.", + "output": "Surgical construction of arteriovenous shunt, NOS (Vascular Grafting)" + }, + { + "input": "Definition: something described as protein kinase A regulatory subunit RII-alpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP350 (also known as AKAP450 and CGNAP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the onset of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kinase, having a catalytic domain homologous to the PKC family in the C-terminal region and a unique regulatory region in the N-terminal region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kinases and phosphatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott).", + "output": "Centrosome Pathway (Regulatory Pathway)" + }, + { + "input": "Definition: CARDIOVASCULAR FUNCTIONS: GENERAL TERMS described as internal resistance of the blood to shear forces; an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as sickle cell anemia and polycythemia.", + "output": "Viscosity, Blood (Cardiovascular Physiological Phenomena)" + }, + { + "input": "Definition: Disease Response described as the disappearance of all cells with morphologic characteristics of cancer, accompanied by incomplete bone marrow recovery, as evidenced by persistent anemia, thrombocytopenia or neutropenia.", + "output": "Morphologic CRi (Disease Response)" + }, + { + "input": "Definition: Measuring Instruments, Dimension described as a caliper for clinical use is a compass-like device intended for use in measuring the thickness or diameter of a part of the body or the distance between two body surfaces, such as for measuring an excised skeletal specimen to determine the proper replacement size of a prosthesis.", + "output": "CALIPER (Therapeutic Device)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 4 Weeks Version - These are questions about other effects that your respiratory problems may have on you these days: Everything seems too much of an effort.", + "output": "SGRQ Past 4 Weeks Version - Everything Too Much Effort (Intellectual Product)" + }, + { + "input": "Definition: Manufactured Object described as a conductor that is designed to make contact with part of a circuit or system.", + "output": "Electrode (Miscellaneous Supplies)" + }, + { + "input": "Definition: Breast Cancer Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor. Lobular carcinoma in situ (LCIS) is a benign entity and is removed from TNM staging in the AJCC Cancer Staging Manual, 8th Edition.", + "output": "Breast Carcinoma Pathologic Primary Tumor TNM Finding v8 (Breast Cancer Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Neoplastic Process described as a kidney neoplasm of the pronephric cell type that occurs in a frog.", + "output": "Frog Pronephric Kidney Tumor (Experimental Organism Neoplasm by Organism)" + }, + { + "input": "Definition: something described as the Short Form 36 Health Survey Acute, Version 1.0 (SF36 v1.0 Acute) Question 5b.", + "output": "SF-36 v1.0 Acute - Question 5b (SF36 v1 0 Acute Questionnaire Question)" + }, + { + "input": "Definition: Manufactured Object described as lower-limb muscle strength exercisers designed to provide resistance to muscular contraction when the user performs hip rotations using a mechanism based on a system of levers. These exercisers are usually a stand-alone machine with weights stacked on top of each other, a system to transmit the force (i.e., to convey the resistance), and lever bars on which the user exerts force to counteract the exerciser resistance. Typically, the user puts one thigh in the bar pad and performs rotary movements of the hips. Hip rotation exercisers are intended to improve muscle strength in the hips, increase muscle size, enhance muscle endurance and power, and improve bone density.", + "output": "Exercisers, Muscle Strength, Lever/Pulley-Cable, Lower Limb, Hip Rotation (Manufactured Object)" + }, + { + "input": "Definition: Organic Chemical described as an orally active 2-phenylaminopyrimidine derivative with potential antineoplastic activity. INNO-406 specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). Furthermore, this agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. The inhibitory effect of INNO-406 on these specific tyrosine kinases decreases cellular proliferation and induces apoptosis. A high percentage of CML patients are refractory to imatinib, which sometimes results from point mutations occurring in the kinase domain of the Bcr/Abl fusion product. Due to its dual inhibitory activity, INNO-406 has been shown to overcome this particular drug resistance and to be a potent and effective agent in the treatment of imatinib-resistant CML.", + "output": "bafetinib (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Hydrolase described as enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.", + "output": "Type II Site Specific Deoxyribonucleases (Enzyme)" + }, + { + "input": "Definition: something described as an assessment of the disease response to therapy within the spleen.", + "output": "SPLNRESP (Disease Response)" + }, + { + "input": "Definition: Chromosomes, Human, 1-3 described as a specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.", + "output": "CHROMOSOME 03 (NUCLEUS AND ASSOCIATED STRUCTURES)" + }, + { + "input": "Definition: something described as any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage.", + "output": "Abnormal liver morphology (Abnormality of the liver)" + }, + { + "input": "Definition: Mansonella described as a species of parasitic nematodes in the family Onchocercidae. The lifecycle of M. streptocerca involves biting midges and humans. Infestation causes streptocerciasis.", + "output": "MANSONELLA STREPTOCERCA (Eukaryote)" + }, + { + "input": "Definition: something described as this gene may be involved in cell shape and cell motility.", + "output": "LPP (Gene or Genome)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the islet cell 512 antigen in a biological specimen.", + "output": "Islet Cell 512 Antigen Measurement (Immunologic Tests)" + }, + { + "input": "Definition: Cell Component described as a SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.", + "output": "GBAF complex location (Cell Component)" + }, + { + "input": "Definition: Germicide described as germicides intended for use in liquid-phase for killing and/or total inactivation of many microorganisms (e.g., viruses, bacteria, fungi). These germicides typically consist of a non-corrosive chemical solution used in disinfecting or sterilizing units that include a closed chamber in which the time, temperature, and/or concentration of the germicide during the sterilization (typically by immersion) process are controlled. Liquid germicides usually require high concentrations, elevated temperatures, and several hours of exposure time for sterilization purposes. Therefore, they are mainly used for disinfection rather than for sterilization purposes. Liquid germicides are used mainly to disinfect medical devices and supplies that cannot be heat-sterilized due to their sensitivity to high temperatures (e.g., devices including plastic and/or rubber components). The most frequently used liquid germicides are glutaraldehyde, hydrogen peroxide, and ortho-phthalaldehyde.", + "output": "Liquid Germicides (Germicide)" + }, + { + "input": "Definition: Propylpiperazine derivative of phenothiazine described as a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.", + "output": "Etaperazin (Phenothiazine derivatives)" + }, + { + "input": "Definition: Organic Chemical described as a fungal toxin isolated from Arachniotus aureus with activity against RNA viruses such as poliovirus, coxsackie virus, and rhino- and parainfluenza viruses. Aranotin inhibits viral RNA synthesis by impeding the activity of RNA-dependent RNA polymerase.", + "output": "ARANOTIN (RNA Polymerase Inhibitor)" + }, + { + "input": "Definition: Biochemistry described as the branch of biochemistry that is specifically concerned with the structure, synthesis, maintenance and biological pathways that involve nucleotides.", + "output": "Nucleotide Biochemistry (Occupation or Discipline)" + }, + { + "input": "Definition: Phenoxypropanolamines described as an adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.", + "output": "2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-((1,1-dimethylethyl)amino)-, hydrochloride, (+-)- (Adrenergic beta-Antagonists)" + }, + { + "input": "Definition: Hypoalbuminemia, CTCAE 5 described as <2 g/dL; <20 g/L", + "output": "Grade 3 Hypoalbuminemia (Hypoalbuminemia, CTCAE 5)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the unnamed portion of the basal nucleus of the amygdala in atlases in which the basal nucleus of the amygdala is not fully segmented. The structure is not necessarily the same in different atlases.", + "output": "BA-n (basolateral nucleus of the amygdala)" + }, + { + "input": "Definition: Treponemal Infections described as an endemic bacterial infection caused by Treponema carateum. It is manifested with chronic cutaneous lesions. The early lesions consist of papules and erythematous plaques. The late lesions consist of hypochromic, achromic, hyperpigmented and atrophic lesions. The late skin lesions may cause destruction of bones and cartilage and produce disfiguring changes.", + "output": "Pinta (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a surgically created external opening into the renal pelvis.", + "output": "Nephrostomy site (Finding)" + }, + { + "input": "Definition: Apoptosis Regulation Pathway described as vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB.", + "output": "T-Cell Antiapoptosis Pathway (Immune Response Regulation Pathway)" + }, + { + "input": "Definition: Conceptual Entity described as any state or process known through the senses rather than by intuition or reasoning.", + "output": "Phenomena (Phenomenon or Process)" + }, + { + "input": "Definition: Enjoyment of life - finding described as inability to experience pleasure activities usually found enjoyable.", + "output": "anhedonia (Neurobehavioral Manifestations)" + }, + { + "input": "Definition: Inorganic Chemical described as inorganic compounds that contain bromine as an integral part of the molecule.", + "output": "Bromine Compounds (Inorganic Chemicals)" + }, + { + "input": "Definition: Biologically Active Substance described as syndecan-4 (198 aa, ~22 kDa) is encoded by the human SDC4 gene. This protein is involved in cell surface localization of heparan sulfate.", + "output": "syndecan 4 protein, human (Cell Adhesion Molecules)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as flotillin-2 (379 aa, ~42 kDa) is encoded by the human FLOT2 gene. This protein plays a role in neuronal signaling and caveolar membrane structure.", + "output": "Epidermal Surface Antigen (Biologically Active Substance)" + }, + { + "input": "Definition: Microbiology procedure described as the determination of the amount of the Clostridium difficile toxin in a sample.", + "output": "Clostridium difficile Toxin Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Laboratory test result abnormal described as an increase in the ratio of cells expressing the immunoglobulin light chain (Ig LC) kappa versus those expressing Ig LC lambda in a sample.", + "output": "Kappa Light Chain-Restriction (Finding)" + }, + { + "input": "Definition: regulation of erythrocyte clearance described as any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance.", + "output": "negative regulation of RBC clearance (negative regulation of immune system process)" + }, + { + "input": "Definition: something described as CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins.", + "output": "CTCF: First Multivalent Nuclear Factor (Molecular Function)" + }, + { + "input": "Definition: something described as blood sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (Argasidae) and hardbacked ticks (Ixodidae); ticks are larger than their relatives, the mites; they penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood; ticks attack all groups of terrestrial vertebrates; in humans they are responsible for many diseases, including the transmission of Rocky Mountain spotted fever, tularemia, babesiosis, African swine fever and relapsing fever.", + "output": "tick (Order Acarina)" + }, + { + "input": "Definition: protein-containing complex described as a protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved.", + "output": "SMC loading complex location (protein-containing complex)" + }, + { + "input": "Definition: Clinical Trial Type described as a type of trial designed to evaluate the effect of body position during and/or after administration of the investigational product.", + "output": "Position Effect Trial (Research Activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.", + "output": "leukocyte adhesion molecule (Endogenous Substances Receptors)" + }, + { + "input": "Definition: something described as abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds.", + "output": "Rhonchus (Finding)" + }, + { + "input": "Definition: Spatial Concept described as physical location of EXT2_Gene", + "output": "11: 44073675-44223556 (Chromosome 11 Physical Location)" + }, + { + "input": "Definition: Aerococcaceae described as any bacteria that is not assigned to the species level but can be assigned to the Globicatella genus level.", + "output": "Genus Globicatella (Bacterium)" + }, + { + "input": "Definition: Medical Device described as cryptococcus neoformans serological reagents are devices that consist of antigens used in serological tests to identify antibodies to Cryptococcus neoformans in serum. Additionally, some of these reagents consist of antisera conjugated with a fluorescent dye (immunofluorescent reagents) and are used to identify Cryptococcus neoformans directly from clinical specimens or from cultured isolates derived from clinical specimens. The identification aids in the diagnosis of cryptococcosis and provides epidemiological information on this type of disease. Cryptococcosis infections are found most often as chronic meningitis (inflammation of brain membranes) and, if not treated, are usually fatal.", + "output": "CANDIDA SPP., DIRECT ANTIGEN, ID (Medical Device)" + }, + { + "input": "Definition: Enzyme described as a subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an amino-terminal FERM domain, an intervening region containing one or more PDZ domains, and a carboxyl-terminal phosphatase domain. The subtype was originally identified in a cell line derived from MEGAKARYOCYTES.", + "output": "protein tyrosine phosphatase, non-receptor type 4 (Enzyme)" + }, + { + "input": "Definition: Intellectual Product described as a bibliographical reference in a format acceptable to the publisher of the reference material.", + "output": "Study Reference Citation Description (Citation Description)" + }, + { + "input": "Definition: something described as a rare glial neoplasm more commonly found in young adults. It is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly. The cells have broad, non-tapering processes radiating towards a central blood vessel. The biologic behavior of astroblastomas is variable, so no WHO grade has been established, yet.", + "output": "Astroblastoma (Neuroepithelial tumor morphology of uncertain origin)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as interferon regulatory factor 4 (451 aa, ~52 kDa) is encoded by the human IRF4 gene. This protein is involved in the mediation of both T-cell activation and interferon-stimulated response element promoter-dependent gene expression.", + "output": "LSIRF (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: CDRS-R Clinical Classification Question described as children's Depression Rating Scale, Revised - Impaired schoolwork.", + "output": "CDRS101 (Intellectual Product)" + }, + { + "input": "Definition: Dentistry described as investigation or experimentation aimed at the discovery and interpretation of facts, revision of accepted theories or laws in the light of new facts, or practical application of such new or revised theories or laws in relation to dental science and dental care.", + "output": "Research, Dental (Dentistry)" + }, + { + "input": "Definition: something described as a drug used to control pain and to cause a temporary loss of feeling in one part of the body, during and after surgery. It is also being studied for pain control after cancer surgery. It is a type of local anesthetic.", + "output": "Ropivacaine Monohydrochloride (Anesthetics)" + }, + { + "input": "Definition: transferase activity, transferring phosphorus-containing groups described as catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).", + "output": "phosphotransferase activity, for other substituted phosphate groups (Molecular Function)" + }, + { + "input": "Definition: something described as a quantitative value that is the compilation of assessed size and densities of calcium deposits throughout the coronary tree.", + "output": "Coronary Artery Calcium Scoring (Quantitative Concept)" + }, + { + "input": "Definition: Neonatal Rash, Adverse Event described as an adverse event in a newborn characterized by diffuse rash or target lesions.", + "output": "Grade 2 Rash Neonatal (Neonatal Rash, Adverse Event)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.", + "output": "Valve, Aortic (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Organism Function described as determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis.", + "output": "determination of dorsoventral asymmetry (determination of bilateral symmetry)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as all components of paleocortex except the piriform area, which is different in origin phylogenetically and ontogenetically ( Stephan-1975 ).", + "output": "semicortex (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of protein localization to cell tip.", + "output": "up regulation of protein localisation to cell tip (positive regulation of cellular protein localization)" + }, + { + "input": "Definition: Organic Chemical described as kalara, oriya.", + "output": "momordica charantia/kalara/o (Organic Chemical)" + }, + { + "input": "Definition: Solid Dose Form described as a substance intended for administration in or on a wound.", + "output": "Dressing Dosage Form (Solid Dose Form)" + }, + { + "input": "Definition: something described as a rare cancer that forms in the part of the bile duct that is outside the liver. The bile duct is the tube that collects bile from the liver and joins a duct from the gallbladder to form the common bile duct, which carries bile into the small intestine when food is being digested.", + "output": "Carcinoma of extrahepatic bile duct (Malignant tumor of extrahepatic bile duct)" + }, + { + "input": "Definition: Genital Diseases, Male described as a problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity", + "output": "sexual dysfunction male (Abnormal male reproductive system physiology)" + }, + { + "input": "Definition: Intellectual Disability described as the 19q13.11 microdeletion has characteristics of several major features including pre and postnatal growth retardation, slender habitus, severe postnatal feeding difficulties, microcephaly, intellectual deficit with speech disturbance, hypospadias and ectodermal dysplasia presented by scalp aplasia, thin and sparse hair, eyebrows and eyelashes, thin and dry skin and dysplastic nails. To date, the syndrome has been identified in five patients. Haploinsufficiency of one or more genes in the 19q13.11 region could cause this microdeletion syndrome.", + "output": "19q13.11 microdeletion syndrome (Anomaly of chromosome pair 19)" + }, + { + "input": "Definition: stage, adult acute lymphoblastic leukemia described as precursor lymphoblastic leukemia in adults which is not growing and responds to treatment. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7937\" active clinical trials using this agent.", + "output": "Adult Acute Lymphoblastic Leukemia in Remission (Neoplastic Process)" + }, + { + "input": "Definition: Abnormality of skin adnexa morphology described as any structural anomaly of the sebaceous glands.", + "output": "Abnormal sebaceous gland morphology (Abnormality of skin adnexa morphology)" + }, + { + "input": "Definition: something described as this gene is involved in transcriptional regulation.", + "output": "FORKHEAD BOX D3 (Transcription factor genes)" + }, + { + "input": "Definition: Finding described as absence of clonal plasma cells by next-generation sequencing on bone marrow aspirate in which presence of a clone is defined as less than two identical sequencing reads obtained after DNA sequencing of bone marrow aspirates using the LymphoSIGHT platform (or validated equivalent method) with a minimum sensitivity of 1 in 10^5 nucleated cells or higher.", + "output": "IMWG Sequencing MRD-negative (Finding)" + }, + { + "input": "Definition: Scanning laser ophthalmoscopy described as a technique of diagnostic imaging of RETINA or CORNEA of the human eye involving the measurement and interpretation of polarizing ELECTROMAGNETIC WAVES such as radio or light waves. It is helpful in the diagnosis of GLAUCOMA; MACULAR DEGENERATION; and other retinal disorders.", + "output": "Laser Polarimetries, Scanning (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as a measurement of the sum of durations of wakefulness episodes throughout the night, not including the wakefulness before sleep onset.", + "output": "Wake After Sleep Onset (Polysomnography)" + }, + { + "input": "Definition: Neoplastic Cell Transformation described as malignant transformation and proliferation of B lymphocytes.", + "output": "B-Lymphoma Development (Neoplastic Process)" + }, + { + "input": "Definition: Deafness described as hearing loss in the absence of auditory system pathology.", + "output": "Hearing Loss, Functional (Ear Diseases)" + }, + { + "input": "Definition: Failure of differentiation of bones of forearm described as an abnormal osseous union (fusion) between the ulna and the humerus.", + "output": "Humeral ulnar synostosis (Disorder of upper arm)" + }, + { + "input": "Definition: Central Nervous System described as incomplete development of the pituitary gland.", + "output": "Pituitary gland hypoplasia (Non-Neoplastic Pituitary Gland Disorder)" + }, + { + "input": "Definition: Rongeur described as an ear, nose, and throat manual surgical instrument is one of a variety of devices intended for use in surgical procedures to examine or treat the bronchus, esophagus, trachea, larynx, pharynx, nasal and paranasal sinus, or ear. This generic type of device includes the esophageal dilator; tracheal bistour (a long, narrow surgical knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tub; tonsil suturing hook; antom reforator; ethmoid curette; frontal sinus-rasp; nasal curette; nasal rasp; nasal rongeur; nasal saw; nasal scissors; nasal snare; sinus irrigator; sinus trephine; ear curette; ear excavator; ear rasp; ear scissor, ear snare; ear spoon; ear suction tub; malleous ripper; mastoid gauge; microsurgical ear chisel; myringotomy tube inserter; ossici holding clamp; sacculotomy tack inserter; vein press; wire ear loop; microrule; mirror; mobilizer; ear, nose, and throat punch; ear, nose and throat knife; and ear, nose, and throat trocar.", + "output": "Nasal rongeur (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as human CYP3A5*3 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*3 protein. The CYP3A5*3 allele exhibits a clinically-relevant SNP (g.6986A>G) in intron 3 that results in a splicing defect and premature stop at 102 amino acids. This alteration severely decreases the enzymatic activity of the cytochrome P450 3A5*3 protein.", + "output": "CYP3A5, g.6986A>G (Gene or Genome)" + }, + { + "input": "Definition: Cell Function described as the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase.", + "output": "mitotic spindle elongation during mitotic prophase (Cell Function)" + }, + { + "input": "Definition: Structure of choroid and/or retina of right eye described as layer of wall of right eyeball which is continuous with right optic nerve.", + "output": "Structure of retina of right eye (Right eye)" + }, + { + "input": "Definition: Anatomical Abnormality described as irregularity of the normally smooth surface of the metaphysis of the ulna.", + "output": "Ulnar metaphyseal irregularity (Upper-limb metaphyseal irregularity)" + }, + { + "input": "Definition: Primary malignant neoplasm of body of uterus described as a rare subtype of mixed epithelial-mesenchymal tumour, often presenting as a large, exophytic polypoid lesion, which may extend through the cervix, composed of benign or atypical epithelium and low-grade malignant stroma. It usually presents with dysfunctional bleeding or vaginal discharge and less frequently abdominal pain. Association with long-term unopposed oestrogen therapy, tamoxifen therapy and a history of pelvic radiation has been reported.", + "output": "Adenosarcoma of corpus uteri (Primary malignant neoplasm of body of uterus)" + }, + { + "input": "Definition: Hospitalization & Institutionalization described as visiting a patient or convict in an institution (e.g., hospital, prison, or nursing home) by someone from outside the institution (e.g., friends or family).", + "output": "Institution Visitation (Hospitalization & Institutionalization)" + }, + { + "input": "Definition: Unit of mass described as a unit of mass derived from the weight of a grain and equal to one seven-thousandth of a pound, or 1/480 troy ounce, or 64.79891 milligrams. The original English grain unit based on the mass of a ripe grain barleycorn was larger the corresponding grain units of France and other European nations which were based on the weight of the smaller wheat grain.", + "output": "gr (Unit of mass)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of a methane from a formic acid.", + "output": "methane biosynthetic process from formic acid (formate metabolic process)" + }, + { + "input": "Definition: Pharmacologic Substance described as nicotiana.", + "output": "Nicotiana alata / nicotiana (Pharmacologic Substance)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Blood Disorder, Hemolytic Anemia, Thalassemia described as molecular assay reagents intended to identify mutations in genes associated with thalassemia, a form of hemolytic anemia caused by defective hemoglobin. Genetic variants at multiple loci have been associated with various forms of thalassemia. These reagents are intended to detect mutations in the majority of thalassemia-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Blood Disorder, Hemolytic Anemia, Thalassemia, Comprehensive, Mutation (IVD Panels, Human Genetics, Blood Disorder, Hemolytic Anemia, Thalassemia)" + }, + { + "input": "Definition: Forensic Sciences described as branch of medicine that interprets or establishes the medical facts in civil or criminal law cases.", + "output": "MED FORENSIC (Medical Specialities)" + }, + { + "input": "Definition: something described as a keratoscope is a battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device includes the photokeratoscope which records corneal curvature by taking photographs of the cornea.", + "output": "Corneal Topographers (Device system)" + }, + { + "input": "Definition: Finding described as the patient was unwell at the time the chief complaint was manifested.", + "output": "Yes (Other Finding)" + }, + { + "input": "Definition: St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 4 Weeks Version - These are questions about what activities usually make you feel short of breath these days: Walking outside on level ground.", + "output": "SGRQ02-Walking Outside on Level Ground (Intellectual Product)" + }, + { + "input": "Definition: Devices described as device for the administration of a measured quantity of a product. Only to be used when other terms are not applicable.", + "output": "Measurement Device (Devices)" + }, + { + "input": "Definition: Finding described as supranormal concentration of prolactin.", + "output": "Increased circulating prolactin concentration (Hyperpituitarism)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as subdivision of fibrous skeleton of heart which attaches the right posterior cusp of aortic valve to the wall of heart.", + "output": "Right posterior semilunar fibrous scallop of aortic valve anulus (Subdivision of fibrous skeleton of heart)" + }, + { + "input": "Definition: Molecular Function described as any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.", + "output": "positive regulation of long-chain fatty acid import across plasma membrane (positive regulation of anion transmembrane transport)" + }, + { + "input": "Definition: Multipolar neuron described as neurons which activate MUSCLE CELLS.", + "output": "motor cell (Sensory-Somatic Nervous System)" + }, + { + "input": "Definition: Non-Autonomic Spinal Nerves described as denotes the 31 pairs of nerves that exit the spinal cord. They include 8 cervical, 12 thoracic, 5 lumbar, 5 sacral and 1 coccygeal nerve pairs. As substructures of the peripheral nervous system, they are not in the NeuroNames hierarchy ( Carpenter-1983 ).", + "output": "Nerves (Peripheral Nerves)" + }, + { + "input": "Definition: Transcription factor genes described as this gene plays a role in transcriptional activation.", + "output": "EBF (Transcription factor genes)" + }, + { + "input": "Definition: Intellectual Product described as emotion Recognition Test (ERT) Number of sadness stimuli responded to as fear.", + "output": "EMO1-Sadness Responded as Fear (ERT Functional Test Question)" + }, + { + "input": "Definition: CENTRAL NERVOUS SYSTEM AGENTS: CONVENIENCE TERMS described as substances that reduce or suppress INFLAMMATION.", + "output": "Anti-inflammatory Agent [TC] (anti-inflammatory, anti-infective, and antineoplastic agents)" + }, + { + "input": "Definition: Homeopathic remedies letter P described as parthenium root.", + "output": "parthenium integrifolia/part (Pharmacologic Substance)" + }, + { + "input": "Definition: ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) Regarding eating: which best describes the subject's usual performance during the past 4 weeks?", + "output": "ADL01-Usual Eating Performance (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as a chimeric monoclonal antibody directed against human CD20, with potential antineoplastic activity. Anti-CD20 monoclonal antibody SCT400 binds to the B-cell-specific cell surface antigen CD20, which triggers an immune response against CD20-positive B-cells, leading to apoptosis. CD20, a non-glycosylated cell surface phosphoprotein, is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies.", + "output": "anti-CD20 monoclonal antibody SCT400 (Immunologic Factor)" + }, + { + "input": "Definition: Hepatocellular Carcinoma Clinical Distant Metastasis TNM Finding v8 described as hepatocellular carcinoma without evidence of distant metastasis.", + "output": "Liver Cell Carcinoma cM0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human NPPB wild-type allele is located in the vicinity of 1p36.2 and is approximately 1 kb in length. This allele, which encodes natriuretic peptides B, plays a role in diuresis, vasorelaxation and regulation of renin and aldosterone secretion.", + "output": "NPPB wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Neoplastic Process described as the most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival.", + "output": "Urinary Bladder Urothelial Carcinoma (cellular diagnosis, bladder cancer)" + }, + { + "input": "Definition: something described as brief Pain Inventory (BPI) I believe my pain is due to a medical condition unrelated to my primary disease.", + "output": "BPI1213 (Intellectual Product)" + }, + { + "input": "Definition: Genus: Hymenolepis described as a species of tapeworm in the family Hymenolepididae with a long cylindrical body, 4 suckers, and an apical organ at its scolex with no rostellar hooks. The lifecycle of H. diminuta involves beetles as the intermediate host and rodents as the definitive host. This tapeworm is prevalent in tropical zones worldwide but only rarely infects humans.", + "output": "Rat tapeworm (Genus: Hymenolepis)" + }, + { + "input": "Definition: Brazilian State described as a state in the North Region of Brazil. Its capital is Boa Vista.", + "output": "Roraima (Brazilian State)" + }, + { + "input": "Definition: Chromatin described as the inactive, condensed X chromosome in a female somatic cell.", + "output": "Barr bodies (X Chromosome)" + }, + { + "input": "Definition: Immunoglobulin measurement described as a measurement of the English plantain (Plantago lanceolata) pollen IgG4 in a biological specimen.", + "output": "English Plantain Pollen IgG4 (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a benign tumor consisting of vascular and smooth muscle elements.", + "output": "Angiomyomas (Benign Neoplasm)" + }, + { + "input": "Definition: Gene Feature described as the sequences on a gene or messenger RNA that are translated into protein.", + "output": "Coding Region (Gene or Genome)" + }, + { + "input": "Definition: something described as struggle or disagreement between parents, parent and child or other members of a family.", + "output": "conflict; family (Family dynamics)" + }, + { + "input": "Definition: something described as functional Assessment of Multiple Sclerosis (FAMS) Symptoms: I have pain in my joints.", + "output": "FAMS - I Have Pain in My Joints (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a physical location used by a person or organization for the purpose of receiving postal mail deliveries.", + "output": "Mailing (Address)" + }, + { + "input": "Definition: regulation of transcription from RNA polymerase II promoter by glucose described as any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.", + "output": "positive regulation of transcription from RNA polymerase II promoter by glucose (regulation of transcription from RNA polymerase II promoter by glucose)" + }, + { + "input": "Definition: M [Preparations] described as a methyl ester of methacrylic acid. Methyl methacrylate is a reactive resin, and the polymerized form is used as cement in dentistry, orthopaedic surgery and ophthalmology. The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response.", + "output": "methacrylate methyl (M [Preparations])" + }, + { + "input": "Definition: Curricula described as used for educational and noneducational settings.", + "output": "Environmental Education (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: structural molecule activity described as the action of a molecule that contributes to the structural integrity of bone.", + "output": "structural constituent of bone (structural molecule activity)" + }, + { + "input": "Definition: something described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) The number of words recalled from List A, second attempt.", + "output": "AVL01-List A Recall 2 Total (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with the SNAP receptor syntaxin-3.", + "output": "syntaxin-3 binding (syntaxin binding)" + }, + { + "input": "Definition: Pharmacologic Substance described as an inhibitor of the Bromodomain and Extra-Terminal (BET) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor INCB054329 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular growth.", + "output": "BET inhibitor INCB054329 (Organic Chemical)" + }, + { + "input": "Definition: Genes, Regulator described as this gene may play a role in transcriptional regulation.", + "output": "ZNF678 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as an amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.", + "output": "ISOPROPYL IODOAMPHETAMINE N P (Organic Chemical)" + }, + { + "input": "Definition: Cell Component described as the myosin part of any complex of actin, myosin, and accessory proteins.", + "output": "actomyosin, myosin complex part (Cell Component)" + }, + { + "input": "Definition: Neoplastic Process described as a meningioma that is transmitted from the parents to an offspring.", + "output": "Familial Meningioma (Meningioma)" + }, + { + "input": "Definition: Plant agent product described as oil extracted from fruit of the OLIVE TREE (genus Olea).", + "output": "Oils, Olive (Organic Chemical)" + }, + { + "input": "Definition: Esotropia described as esotropia in a patient who has previously had exotropia or exophoria; may be constant or intermittent and usually follows surgical overcorrection.", + "output": "Consecutive esotropia (Esotropia)" + }, + { + "input": "Definition: something described as the highly vascularized outer layer of the endometrium facing the uterine cavity which develops over the course of the proliferative and secretory phases then degenerates and sloughs off during menstruation.", + "output": "Functional layer of endometrium (Female Reproductive System Part)" + }, + { + "input": "Definition: something described as a measurement to determine human leukocyte antigens (HLA) histocompatibility between the recipient and the donor by examining the presence or absence of the recipient's anti-HLA antibody reactivity towards HLA antigens expressed on the donor B-lymphocytes.", + "output": "BLYMXM (Panel-reactive antibody)" + }, + { + "input": "Definition: Geographic Area described as a country in the Pacific, comprising a group of islands in the North Pacific Ocean, southeast of the Philippines.", + "output": "PLW (Geographic Area)" + }, + { + "input": "Definition: AOD substance or product described as a tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.", + "output": "Coke (Ester type local anesthetic, NOS)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure.", + "output": "mesonephric smooth muscle tissue development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a question about an individual's ability to run or jog 1/4 mile.", + "output": "Running or jogging 1/4 mile (Intellectual Product)" + }, + { + "input": "Definition: Immunologic Factor described as antineoplastic vaccine being developed against liver cancer.", + "output": "GV-1301 (Cancer Vaccines)" + }, + { + "input": "Definition: Intellectual Product described as a list of four factors to assess how an individual with peripheral T-cell lymphoma might respond to treatment and predict the risk of disease recurrence. The factors are: patient's age, LDH levels: serum levels often correlate with the amount of tumor in the body, performance status, and bone marrow involvement.", + "output": "Prognostic Index Score for Peripheral T-cell Lymphoma (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as an identifier that describes the relative position of procedures within a series.", + "output": "Procedure Sequence Number (Sequence Number)" + }, + { + "input": "Definition: something described as congenital hydrocephalus with cerebellar hypoplasia and agenesis of the foramina of Luschka and Magendie. It may occur in association with the otopalatodigital syndrome II.", + "output": "hydrocephalus-cerebellar agenesis syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Membrane Proteins described as rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.", + "output": "Bacteriorhodopsin -RETIRED- (bacterial pigment)" + }, + { + "input": "Definition: Thyroid Cancer Pathologic Distant Metastasis TNM Finding v6 described as thyroid cancer with no evidence of distant metastasis.", + "output": "pM0 Thyroid Cancer (Finding)" + }, + { + "input": "Definition: something described as the determination of the amount of copper present in a sample.", + "output": "Copper (Heavy metals measurement)" + }, + { + "input": "Definition: Existing client in-office without ICD diagnosis described as assessing the health status of an existing massage therapy client in a simple, subsequent, 10-minute, in-office meeting to reevaluate and/or develop a treatment plan for somatic education, massage therapy and/or bodywork.", + "output": "Simple subsequent 10 minutes in-office massage therapy intake (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Fat-soluble vitamin described as a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.", + "output": "(+/-)-alpha-Tocopherol (tocopherol)" + }, + { + "input": "Definition: plant organ morphogenesis described as morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "output": "post-embryonic plant organ morphogenesis (plant organ morphogenesis)" + }, + { + "input": "Definition: Finding described as a disorder characterized by non-neoplastic overgrowth of bone.", + "output": "Exostosis (Musculoskeletal and Connective Tissue Disorders, CTCAE)" + }, + { + "input": "Definition: Finding described as oropharyngeal (p16-negative) cancer with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-).", + "output": "Oropharyngeal (p16-Negative) Carcinoma cN3a TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Spinal Cord Diseases described as inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.", + "output": "Inflammations, Spinal Cord (Inflammatory disorder of head)" + }, + { + "input": "Definition: something described as a minor branch of the sciatic nerve that includes the lateral and caudal sural nerves, which innervates the skin of the crus, tarsus and metatarsus.", + "output": "nerve sural (Spinal nerve structure)" + }, + { + "input": "Definition: something described as a radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123) with potential radioimmunolocalization applications. The antibody moiety of iodine I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively delivering I-123 upon cellular internalization and allowing the scintigraphic imaging of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution, and a lower potential for eliciting an immune response.", + "output": "Iodine I 123 Anti-CEA Recombinant Diabody T84.66 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as placement of intracoronary devices across the coronary stenosis is troublesome or formidable.", + "output": "Difficulty Crossing Culprit Lesion During Percutaneous Coronary Intervention (Finding)" + }, + { + "input": "Definition: something described as the first treatment regimen.", + "output": "Treatment Regimen #1 (Enumerated Treatment Regimens)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling.", + "output": "regulation of gibberellic acid mediated signaling pathway (regulation of signal transduction)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of a large-volume aqueous solution intended for irrigation of body cavities, wounds and surfaces, for example during surgical procedures. Irrigation solutions are either solutions of active substance(s), electrolytes or osmotically active substances in water for injections, or they consist of water for injections as such.", + "output": "irrigation solution (Biomedical or Dental Material)" + }, + { + "input": "Definition: Physical examination procedures and organ system status described as an anomalous (adventitious) sound produced by the breathing process.", + "output": "Respiratory sounds, abnormal (RESPIRATORY SOUNDS, SIGNS AND MECHANISMS OF SOUND PRODUCTION)" + }, + { + "input": "Definition: Intellectual Product described as the National Protocol, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a multi-institutional trial in which the Cancer Center provides leadership or is a participant. The concept includes trials conducted by National Cooperative Groups.", + "output": "National Protocol Standard Cancer Center Information Summary (Document type)" + }, + { + "input": "Definition: something described as problem associated with device markings/labeling, instructions for use, training and maintenance documentation or guidelines.", + "output": "Instructions, Inadequate (Human Factors Issue Associated with Medical Device)" + }, + { + "input": "Definition: Health Care described as the measurement of the size of a tumor mass either clinically or in a surgically resected specimen.", + "output": "Tumor Size Measurement (Health Care)" + }, + { + "input": "Definition: Colloid brain cyst described as colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.", + "output": "Neuroepithelial cysts of third ventricle (Colloid brain cyst)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in immune responses and cell death.", + "output": "CARD15 (Apoptosis Regulation Gene)" + }, + { + "input": "Definition: negative regulation of maintenance of mitotic sister chromatid cohesion described as any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.", + "output": "downregulation of maintenance of mitotic sister chromatin cohesion at telomere (regulation of maintenance of mitotic sister chromatid cohesion, telomeric)" + }, + { + "input": "Definition: something described as the process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.", + "output": "membranous septum morphogenesis (Morphogenesis)" + }, + { + "input": "Definition: something described as a method to purify phosphoproteins or phosphopeptides from a mixture that leverages their affinity to ferric ion-charged NTA-agarose beads. The mixture is loaded on the column at low pH and the phosphorylated proteins or peptides are eluted using alkaline buffers containing edetate at a pH range of 10-11 or phosphate-containing buffers.", + "output": "Immobilized Metal Affinity Chromatography with Phosphopeptide Enrichment (Immobilized Metal Affinity Chromatography)" + }, + { + "input": "Definition: Head and Neck Cancer Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v8 classification system.", + "output": "Major Salivary Gland Cancer Pathologic TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as this gene plays a putative role in apoptosis and the negative regulation of cell growth.", + "output": "tumor suppressor 2, mitochondrial calcium regulator (Tumor Suppressor Genes)" + }, + { + "input": "Definition: Substance described as any of various proprietary tobacco products that deliver nicotine as they dissolve or melt in the user's mouth.", + "output": "Dissolvable Tobacco (Smokeless Tobacco)" + }, + { + "input": "Definition: Regimen Used to Treat Acute Lymphoblastic Leukemia described as a regimen consisting of cyclophosphamide, vincristine, doxorubicin and dexamethasone, administered on a hyperfractionated schedule, alternating with high-dose cytarabine and methotrexate, that can be used in the treatment of acute lymphoblastic leukemia (ALL) and certain types of non-Hodgkin lymphoma (NHL), including Burkitt lymphoma.", + "output": "HyperCVAD-HD MTX AraC Regimen (Regimen Used to Treat Acute Lymphoblastic Leukemia)" + }, + { + "input": "Definition: something described as (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.", + "output": "pge (Prostaglandins)" + }, + { + "input": "Definition: WPPSI-IV subtests described as a subtest of the Wechsler Preschool and Primary Scale of Intelligence, 4th Edition. Depending on the age of the child, this subtest measures either receptive vocabulary or verbal comprehension.", + "output": "WPPSI-IV Vocabulary (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the NSD1/NUP98 fusion gene. This protein is comprised of the N-terminus of the Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific protein, including the nuclear receptor interacting domain, followed by the C-terminus of the nuclear pore complex protein Nup98-Nup96 protein, including the RNA-binding domain.", + "output": "Histone-Lysine N-Methyltransferase, H3 Lysine-36 and H4 Lysine-20 Specific/Nuclear Pore Complex Protein Nup98-Nup96 Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Anatomical Abnormality described as fusion of the middle phalanx of the 3rd finger with another bone.", + "output": "Fused middle bone of middle finger (Abnormality of the middle phalanx of the 3rd finger)" + }, + { + "input": "Definition: something described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to the violation of trial inclusion and exclusion criteria of a subject.", + "output": "Inclusion Exclusion Criteria Not Met Domain (Domain)" + }, + { + "input": "Definition: regulation of cell fate specification described as any process that mediates the specification of a cell into a retinal cone cell.", + "output": "regulation of retinal cone cell fate specification (Cell Function)" + }, + { + "input": "Definition: something described as the value in which the outcome of the pharmacokinetic concentration assessment observation was originally reported.", + "output": "Pharmacokinetic Concentration Original Result (Original Result or Finding)" + }, + { + "input": "Definition: something described as a plant genus of the family RUTACEAE. Members contain BERBERINE, indolopyridoquinazoline and other ALKALOIDS and limonoids.", + "output": "Phellodendrons (Amyridoideae)" + }, + { + "input": "Definition: Disease or Syndrome described as a form of focal dystonia affecting the face and especially the jaw that is induced by the act of speaking. It is an involuntary contraction of the masticatory muscles, resulting in dysarthria or dysphagia.", + "output": "Abnormal craniofacial muscle tone (Focal Dystonia)" + }, + { + "input": "Definition: Chromosome 10 Physical Location described as physical location of FGF8_Gene", + "output": "10: 103525817-103519877 (Chromosome 10 Physical Location)" + }, + { + "input": "Definition: Bladder Cancer pT2 TNM Finding v8 described as bladder cancer with tumor invading deep muscularis propria (outer half).", + "output": "Bladder Carcinoma pT2b TNM Finding v8 (Bladder Cancer pT2 TNM Finding v8)" + }, + { + "input": "Definition: Childhood T Lymphoblastic Leukemia/Lymphoma described as an acute T-lymphoblastic leukemia occurring during childhood.", + "output": "T-cell childhood acute lymphoblastic leukemia (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma)" + }, + { + "input": "Definition: Mental Process described as mental functions of decoding spoken messages to obtain their meaning.", + "output": "Reception of spoken language (Reception of language)" + }, + { + "input": "Definition: Code described as a coded value specifying the roles of individuals who are masked for blinded studies.", + "output": "Blinded Role Code (Code)" + }, + { + "input": "Definition: Immunologic Factor described as a cancer boosting vaccine consisting of tumor-specific shared neoantigens, which are immunogenic and unique across a subset of patients, with potential immunostimulating and antineoplastic activities. Upon administration of the neoantigen-based therapeutic cancer vaccine GRT-R904, which is administered after the initial administration of the priming vaccine GRT-C903, the peptides stimulate the host immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against the shared neoantigens expressed on tumor cells, which results in tumor cell lysis.", + "output": "Shared Neoantigen Cancer Vaccine Boost GRT-R904 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as document that certifies that an audit has taken place (at an investigative site, CRO, or clinical research department of a pharmaceutical company).", + "output": "Audit Cert (Intellectual Product)" + }, + { + "input": "Definition: something described as a synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26661\" active clinical trials using this agent.", + "output": "modafinil (M [Preparations])" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a composite structure that consists of the median raphe nucleuss and the inferior central nucleus of the pontine reticular formation ( Carpenter-1983 ).", + "output": "Raphe Nucleus, Medial (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Atrophic scar described as thin (atrophic) and wide scars.", + "output": "'cigarette paper scarring' (Finding)" + }, + { + "input": "Definition: Triglyceride Metabolism described as the chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.", + "output": "triglyceride catabolism (acylglycerol catabolic process)" + }, + { + "input": "Definition: Loop Diuretic [EPC] described as sulfamyl saluretic and diuretic; has a fast onset and short duration of action and is used in edema and chronic renal insufficiency.", + "output": "Furosemide-containing product (Saluretic agent)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Malignant Hyperthermia described as molecular assay reagents intended to identify deletions and duplications in genes associated with susceptibility to malignant hyperthermia, a severe reaction to certain pharmaceuticals that leads to a rapid rise in body temperature and uncontrolled muscle contractions. Genetic variants at multiple loci have been associated with susceptibility to malignant hyperthermia. These reagents are intended to detect deletions and duplications in multiple malignant hyperthermia-susceptibility loci simultaneously.", + "output": "Malignant Hyperthermia Susceptibility Gene Deletion/Duplication Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Anatomical Abnormality described as individuals with anomalous trichromacy possess three types of cones, but one of the three types of cones has an abnormal spectral sensitivity compared to normal cones.", + "output": "Anomalous trichromacy (Anatomical Abnormality)" + }, + { + "input": "Definition: Antineoplastic Antibody-Drug Conjugate described as an immunoconjugate consisting of a monoclonal antibody directed against a highly-expressed myeloma cell surface antigen covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Anti-myeloma cell surface antigen immunoconjugate BT-062 binds to an unspecified cell surface antigen highly expressed on myeloma cells; upon internalization the DM4 moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of myeloma tumor cells.", + "output": "Maytansinoid-Conjugated Anti-Myeloma Monoclonal Antibody BT062 (Antineoplastic Antibody-Drug Conjugate)" + }, + { + "input": "Definition: Immaterial anatomical entity described as non-material physical anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface. Examples: Apex of lung, vertex of head.", + "output": "Anatomical point (Anatomical boundary entity)" + }, + { + "input": "Definition: Nervous System Disorders - Other, Specify, CTCAE described as asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated", + "output": "Grade 1 Nervous system disorders - Other, specify (Nervous System Disorders - Other, Specify, CTCAE)" + }, + { + "input": "Definition: Chemical procedure described as physiological activity and functions of the liver, including production of bile, removal of glucose from blood, destruction or transformation of toxic compounds, and production of various blood proteins.", + "output": "hepatic function (Physiology)" + }, + { + "input": "Definition: Food described as a chemically heterogeneous group of organic compounds found in food that are insoluble in water but soluble in nonpolar solvents.", + "output": "Dietary fat (Food)" + }, + { + "input": "Definition: something described as constructed around symptoms frequently attributed to drugs, (e.g., nausea, vomiting, dyspepsia, gastroesophageal reflux disease, diarrhea and constipation). Applies to gastrointestinal tract from esophagus to rectum. For this SMQ, \"nonspecific\" means conditions are possible manifestations of multiple diseases. Included: Any non-specific functional condition of the whole gastrointestinal tract; non-specific inflammatory manifestations of the whole gastrointestinal tract; non-specific dysfunctional manifestations of the whole gastrointestinal tract; disorders relative to mucosal erosions; terms from SOC Investigations; terms from SOC Surgical and medical procedures. Excluded: Any dysfunction or inflammation in oropharyngeal cavity; inflammatory or dysfunctional conditions which are independent, well defined nosologic entities (e.g., PT Crohn's disease and PT Colitis ulcerative); infective gastroenteritis. SMQ Gastrointestinal nonspecific dysfunction is for gastrointestinal non-specific conditions that lack a morphological alteration substrate, and that are frequently due to a motility alteration of normal gastrointestinal function.", + "output": "Gastrointestinal nonspecific inflammation and dysfunctional conditions (Classification)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the degree to which an individual feels full of pep right now.", + "output": "Full of pep (Intellectual Product)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a scale developed by Smith, et al, designed to assess an individual's ability to recover from stressful circumstances.", + "output": "Brief Resilience Scale (Intellectual Product)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Prostate Symptom Index 17 Version 2 (NCCN-FACT-FPSI 17 Version 2) I am satisfied with my sex life.", + "output": "NCCN-FACT-FPSI 17 Version 2 - I Am Satisfied With My Sex Life (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: something described as biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.", + "output": "Surface Coated Materials (Biomedical or Dental Material)" + }, + { + "input": "Definition: Gene or Genome described as human FGF20 wild-type allele is located within 8p22-p21.3 and is approximately 9 kb in length. This allele, which encodes fibroblast growth factor 20 protein, is involved in the survival of dopaminergic cells. Allelic variants are associated with Parkinson disease pathology.", + "output": "FGF-20 (FGF20 gene)" + }, + { + "input": "Definition: something described as a route that begins on the surface of a localised lesion.", + "output": "Epilesional route (Functional Concept)" + }, + { + "input": "Definition: Diagnostic procedures on skull, brain, and cerebral meninges described as measurement and interpretation of patient data to regulate intracranial pressure", + "output": "Intracran pressure monitoring (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O.", + "output": "diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity (tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity)" + }, + { + "input": "Definition: Brain described as a cleft-like opening in the wall of the lateral ventricle that appears when the choroid plexus is dissected away. It extends from the interventricular foramen to the end of the temporal horn of the lateral ventricle. The part nearest the interventricular foramen is between the lateral edge of the fornix and the upper surface of the thalamus; in the inferior horn it is between the fimbria and the stria terminalis ( Gray-1918a ).", + "output": "Fissura choroidea (Brain)" + }, + { + "input": "Definition: Neoplastic Process described as neoplasm or cancer representing the collective effects of environmental, external forces, including microorganisms, rather than organic or physiologic dysfunction; use narrower terms where applicable.", + "output": "environment related neoplasm/cancer (Malignant Neoplasms)" + }, + { + "input": "Definition: something described as any process that modulates the quantity of fibrinogen circulating in the bloodstream.", + "output": "regulation of circulating fibrinogen levels (regulation of biological quality)" + }, + { + "input": "Definition: Viral Components described as the lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.", + "output": "viral outside membrane (viral membrane)" + }, + { + "input": "Definition: negative regulation of immune response described as any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.", + "output": "negative regulation of natural killer cell differentiation involved in immune response (regulation of natural killer cell differentiation involved in immune response)" + }, + { + "input": "Definition: something described as acute Physiology and Chronic Health Evaluation II - Heart rate (ventricular response).", + "output": "APCH103 (Intellectual Product)" + }, + { + "input": "Definition: regulation of biological quality described as any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.", + "output": "regulation of heart rate (Physiologic Function)" + }, + { + "input": "Definition: something described as pain in the jaw or ear induced by chewing or otherwise moving the jaw.", + "output": "jaw muscle pain only while chewing (Craniofacial Pain)" + }, + { + "input": "Definition: Clarke's Nucleus described as one of two parts of the thoracic column in the rat. The other is the rostral part of the thoracic column ( Swanson-2004 ).", + "output": "caudal part of the thoracic column (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as an integer specifying the relative preference for considering this relationship before other similar relationships having the same source activity.", + "output": "Defined Criterion Group Option Relationship Priority Number (Intellectual Product)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a 17-ketosteroids test system is a device intended to measure 17-ketosteroids in urine. Measurements of 17-ketosteroids are used in the diagnosis and treatment of disorders of the adrenal cortex and gonads and of other endocrine disorders, including hypertension, diabetes, and hypothyroidism.", + "output": "ZIMMERMAN (SPECTROPHOTOMETRIC), 17-KETOSTEROIDS (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: General Qualifier described as the uppermost part, side, or surface of something.", + "output": "Top (General Qualifier)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a tachykinin receptor.", + "output": "tachykinin receptor binding (Molecular Function)" + }, + { + "input": "Definition: Immunologic Factor described as receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.", + "output": "INTERLEUKIN 2 RECEPT (Interleukin 1+2)" + }, + { + "input": "Definition: Pain by Anatomic Descriptor, CTCAE described as unintended facial pain associated with a medical procedure or administration of a drug.", + "output": "Face pain (Finding)" + }, + { + "input": "Definition: negative regulation of cellular response to vascular endothelial growth factor stimulus described as any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.", + "output": "negative regulation of VEGF-activated signaling pathway (Molecular Function)" + }, + { + "input": "Definition: Enzyme described as exostosin-like 1 (676 aa, ~75 kDa) is encoded by the human EXTL1 gene. This protein is involved in protein glycosylation.", + "output": "Exostosin-Like 1 (Enzyme)" + }, + { + "input": "Definition: Bacterial Structures described as envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria; some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium; most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.", + "output": "Bacterial capsule (Polysaccharides, Bacterial)" + }, + { + "input": "Definition: something described as a rationale for excluding a particular data point or subject from the organ measurement results statistical analysis.", + "output": "Organ Measurements Reason For Exclusion From Statistics (Reason for Exclusion from Statistics)" + }, + { + "input": "Definition: Pituitary Adenoma described as a hormone producing pituitary gland adenoma, associated with a hormonal syndrome.", + "output": "Functioning Adenoma of the Pituitary Gland (Hormone secreting pituitary neoplasms)" + }, + { + "input": "Definition: Alcohol-induced organic mental disorder described as processes and symptomatic effects resulting from abstinence from alcohol. Used for both human and animal populations.", + "output": "Alcohol withdrawal syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.", + "output": "Dynamics, Population (Quantitative Concept)" + }, + { + "input": "Definition: Medical Device described as spinal surgery scissors designed to cut spinal (e.g., spinal disc) tissues during microsurgical procedures. These scissors are typically handheld, manual instruments with two small metallic (e.g., stainless steel) blades with straight sharp tips that slide past each other (i.e., shearing action). The blades are attached by a turnable (e.g., 360 degrees) long shank to handles, with the proximal end conformed as a ring (e.g., ribbon style) to facilitate holding and operating; with the fingers both parts are joined by a swivel pin in the center.", + "output": "Spinal Scissors, Microsurgery (Medical Device)" + }, + { + "input": "Definition: something described as an obstetrician/gynecologist who is capable of managing complex problems relating to reproductive endocrinology and infertility.", + "output": "Allopathic & Osteopathic Physicians; Obstetrics & Gynecology, Reproductive Endocrinology (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as a disorder characterized by an increase in sexual desire.", + "output": "Libido Increased (Psychiatric Disorders, CTCAE)" + }, + { + "input": "Definition: something described as a region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation.", + "output": "dynamic polarity patch at the cell cortex (Cell Component)" + }, + { + "input": "Definition: Diagnostic Procedure described as protocols aimed at reducing the cost of breast MRI to improve access to it as a supplemental screening method. Shorter protocols and shorter acquisition times can be achieved with maintenance of diagnostic accuracy comparable to that obtained with conventional MRI protocols. Use of these abbreviated MRI protocols could result in lower cost and faster throughput, thus increasing availability.", + "output": "Abbreviated Breast MRI Protocol (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as oligodontia is a rare developmental dental anomaly with clinical features that include six or more missing teeth, lack of development of maxillary and mandibular alveolar bone height and reduced lower facial height. Variation in tooth morphology is also observed along with problems in tooth development, eruption and exfoliation. Possible causes of oligodontia include viral disease during pregnancy, genetic predisposition, metabolic imbalances, developmental abnormalities and environmental factors. Autosomal dominant mutations in PAX9 and MSX1 have been found in patients with molar non-syndromic oligodontia.", + "output": "Congenital absence of numerous teeth (Tooth structure)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) CD33 fused to one that is directed against the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-CD33/CD3 BiTE antibody AMG 673, this bispecific antibody binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor cells. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on a variety of cancer cell types, including acute myeloid leukemia (AML). It plays a key role in tumor initiation, proliferation and progression.", + "output": "anti-CD33/CD3 BiTE antibody AMG 673 (Immunologic Factor)" + }, + { + "input": "Definition: Lincosamide Antibiotic described as the monohydrate hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin.", + "output": "Clindamycin hydrochloride monohydrate (Lincosamide Antibiotic)" + }, + { + "input": "Definition: Femoral vein part described as a vein that accompanies the common femoral artery and originates at the confluence of the femoral vein and the deep femoral vein.", + "output": "Common femoral vein (Zone of trunk of femoral vein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-.", + "output": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as roland Morris Disability Questionnaire (RDQ) Because of my back, I try not to bend or kneel down.", + "output": "RDQ - Try Not to Bend or Kneel (RDQ Questionnaire Question)" + }, + { + "input": "Definition: something described as a fusion and stereoscopic target is a device intended for use as a viewing object with a stereoscope (Sec. 886.1870).", + "output": "TARGET, FUSION AND STEREOSCOPIC (Medical Device)" + }, + { + "input": "Definition: something described as this gene may be involved in cytoskeletal rearrangement.", + "output": "PDLIM3 (Cytoskeletal Gene)" + }, + { + "input": "Definition: something described as department of Defense (DOD). According to the FY2004 Defense Appropriations Act, DOD is responsible for funding of several cancer research programs such as studies on breast, ovarian, and prostate cancer, leukemia, and myeloproliferative disease.", + "output": "Department of Defense (Organization)" + }, + { + "input": "Definition: Abnormality of the proximal phalanx of the 3rd finger described as presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger.", + "output": "Hypersegmentation of proximal phalanx of third finger (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as this gene plays a role in chromatin remodeling and regulation of transcription.", + "output": "SMARCD1 Gene (Protein Complex Subunit Gene)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the modulation of cell cycle progression.", + "output": "FBX5 (Gene or Genome)" + }, + { + "input": "Definition: Design, Analysis & Interpretation described as a statistical approach in psychological measurement. Also known as item characteristic curve theory.", + "output": "Item Response Theory (Intellectual Product)" + }, + { + "input": "Definition: Chromosome 17 Physical Location described as physical location of MAFG_Gene", + "output": "17: 77474382-77469438 (Spatial Concept)" + }, + { + "input": "Definition: Social Problems described as the employment of youth.", + "output": "child labor (Employment)" + }, + { + "input": "Definition: Other cytotoxic antibiotics in ATC described as a tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.", + "output": "Plicamycin-containing product (Antibiotic)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the largest muscle in the quadriceps femoris that is responsible for extending and stabilizing the knee.", + "output": "lateralis vastus (Muscle of anterior compartment of thigh)" + }, + { + "input": "Definition: Laboratory or Test Result described as the presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor.", + "output": "Insulin receptor antibody positivity (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v6 classification system. TNM pathologic findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.", + "output": "Breast Cancer Pathologic TNM Finding v6 (Breast Cancer TNM Finding v6)" + }, + { + "input": "Definition: something described as a dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived peptides, with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide (LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration, HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C114293\" active clinical trials using this agent.", + "output": "HER-2 pulsed DC1 Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as human CCN1 wild-type allele is located in the vicinity of 1p22.3 and is approximately 3 kb in length. This allele, which encodes CCN family member 1 protein, is involved in heart morphogenesis, angiogenesis, cell proliferation, cell adhesion and the positive regulation of apoptosis.", + "output": "CYR61 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Neoplasm by Special Category described as the original tumor.", + "output": "primary (Neoplasm by Special Category)" + }, + { + "input": "Definition: something described as a gluten-free, calorie-dense, milkshake-like nutritional supplement drink containing all essential vitamins, minerals, and trace elements, as well as protein, fat and carbohydrates. Upon oral intake, gluten-free compact nutritional supplement drink may aid in the prevention of malnutrition and weight loss. The drink is provided in a reduced volume (125 ml) but with the same complete nutrition as the standard drink (200 ml); the reduced volume may increase patient compliance. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120033\" active clinical trials using this agent.", + "output": "gluten-free compact nutritional supplement drink (Food)" + }, + { + "input": "Definition: Receptor Tyrosine Kinase Gene Amplification described as a molecular genetic abnormality indicating the presence of multiple copies of the FLT4 gene.", + "output": "VEGFR3 Amplification (Receptor Tyrosine Kinase Gene Amplification)" + }, + { + "input": "Definition: Organic Chemical described as a nicotinic acid derivative with antilipidemic activity.", + "output": "2,6-pyridinediyldimethylene bis(3,4,5-trimethoxybenzoate) (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as king crab.", + "output": "Limulus cyclops / king crab (Pharmacologic Substance)" + }, + { + "input": "Definition: Nutrition Disorders described as any disorder caused by an insufficient amount or availability of potassium, which generally manifests with myalgia, tetany, hypotension, polyuria, and polydipsia.", + "output": "Potassium Deficiency Disorder (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body.", + "output": "anterograde dendritic transport of mitochondrion (dendritic transport of mitochondrion)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as teaching a parent and/or parents and/or guardian how to assess and monitor his or her dependent child's or adult-child's consciousness to determine when professional assistance is required. Service is billed in 15-minute increments.", + "output": "Consciousness assessment education individual each 15 minutes (Parenting education and/or skills training)" + }, + { + "input": "Definition: Mass Spectrometry described as a mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample- matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.", + "output": "MALDI MS (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.", + "output": "Uterine Infection, CTCAE (Infections and Infestations, CTCAE)" + }, + { + "input": "Definition: Professional or Occupational Group described as a registered nurse with an advanced degree in nursing who specializes in the care of children.", + "output": "Clinical Specialist in Pediatric Nursing (Professional or Occupational Group)" + }, + { + "input": "Definition: Intellectual Product described as a questionnaire designed to assess a patient's perceptions of the degree to which their specific doctor supports the patient's autonomy.", + "output": "The Health Care Climate Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as geriatric Depression Scale (GDS) Do you enjoy getting up in the morning?", + "output": "GDS - Enjoy Getting Up in the Morning (GDS Questionnaire Question)" + }, + { + "input": "Definition: Indoleacetic Acids described as a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.", + "output": "Acid, 5-Hydroxyindolamine Acetic (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Qualitative Concept described as modified by personal feeling or bias.", + "output": "Subjective (Qualitative Concept)" + }, + { + "input": "Definition: Growth Factor Gene described as this gene plays a role in angiogenesis, lymphangiogenesis, and endothelial cell growth.", + "output": "FIGF (Growth Factor Gene)" + }, + { + "input": "Definition: Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8 described as stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm.", + "output": "Lugano Classification Stage IIE Childhood Hodgkin Lymphoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as a finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).", + "output": "Rectal anastomotic leak (Finding)" + }, + { + "input": "Definition: UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Independence scale score.", + "output": "UHDR191 (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: Identifier described as a unique symbol that establishes identity of the product within the context of another product. EXAMPLE(S): OTHER NAME(S): NOTE(S): There are multiple ways in which an identifier can be associated to a product; inherited from MaterialIdentifier.identifier, the association to ProcessedProduct.identifier, and the association to ProductRelationship.identifier. If there is no context associated with the identifier, then MaterialIdentifier.identifier should be used. However, if the identifier for a product would be different in different context, one of the other identifiers should be used. If a kind of product is produced by different processors, and each processor assigns the product a different identifier, then ProcessedProduct.identifier should be used. If the product is used in multiple assemblies, and in each assembly it would be assigned a different identifier, then ProductRelationship.identifier should be used.", + "output": "Product Relationship Identifier (Intellectual Product)" + }, + { + "input": "Definition: Diagnostic Equipment, Ophthalmological described as ophthalmic instruments designed to measure the central (usually 30 degrees) visual field by presenting stimuli on the screen. These instruments usually consist of a white screen, which provides one or multiple static or mobile targets to hold the patient's fixation, and one or more static or mobile test stimuli. The patient focuses on the fixation targets and the perception of his or her response to the test stimuli is assessed. Campimeters can be manually or automatically operated using a camera to monitor the patients' fixation and computerized components to present different stimuli and to measure, analyze, and plot the visual field; they are used mainly to detect glaucoma and other eye disorders.", + "output": "Campimeters (Medical Device)" + }, + { + "input": "Definition: Organ or Tissue Function described as the pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.", + "output": "left/right pattern formation (regionalization)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in mitochondrial fusion.", + "output": "CPRP1 (Gene Mutation)" + }, + { + "input": "Definition: Cross Infection described as pneumonia acquired during a hospital stay.", + "output": "nosocomial pneumonias (Infective pneumonia)" + }, + { + "input": "Definition: Intellectual Product described as body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index - BODE score.", + "output": "BODE01-BODE Score (Intellectual Product)" + }, + { + "input": "Definition: P [Preparations] described as a pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis.", + "output": "Praziquantel (isoquinoline)" + }, + { + "input": "Definition: Social Behavior described as physical or psychological sexual threats or attempts to willfully subject a person to involuntary sexual activity usually for the purpose of social control.", + "output": "Harrassments, Sexual (Sexually abusive behavior)" + }, + { + "input": "Definition: Organic Chemical described as a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1340\" active clinical trials using this agent.", + "output": "N-trifluoroacetyladriamycin 14-valerate (Organic Chemical)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in cell cycle regulation. It is also putatively involved in glucose production.", + "output": "SERINE/THREONINE PROTEIN KINASE 11 (Gene Mutation)" + }, + { + "input": "Definition: something described as a protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.", + "output": "alpha4-beta1 integrin-CD53 complex location (plasma membrane protein complex)" + }, + { + "input": "Definition: Congenital Abnormality described as a cyst that develops from the remnants of the urachus. Since urachal cysts are non-communicating, they are usually asymptomatic unless infected.", + "output": "urachal cyst (Congenital Abnormality)" + }, + { + "input": "Definition: CTHRC1 gene described as human CTHRC1 wild-type allele is located in the vicinity of 8q22.3 and is approximately 11 kb in length. This allele, which encodes collagen triple helix repeat-containing protein 1, plays a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations in this gene are associated with Barrett esophagus/esophageal adenocarcinoma.", + "output": "UNQ762/PRO1550 (CTHRC1 gene)" + }, + { + "input": "Definition: something described as autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 CD8alpha T-cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells.", + "output": "Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells (Cell)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion.", + "output": "downregulation of calcitonin secretion (Cell Function)" + }, + { + "input": "Definition: something described as perceptible especially by the eye; open to easy view.", + "output": "visible (General Qualifier)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a component of the nuclei of stria terminalis defined on the basis of topology, connectivity and multiple stains in the rat. It is one of nine components of the anterior nuclei of stria terminalis in the Functional CNS Model - Rat ( Swanson-2004 ).", + "output": "magnocellular nucleus of stria terminalis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Neonatal Administration Site Complication, AE described as erythema with associated symptoms (e.g., edema, pain, induration, phlebitis).", + "output": "Grade 2 Neonatal Administration Site Complication, Adverse Event (Neonatal Administration Site Complication, AE)" + }, + { + "input": "Definition: something described as an adverse event (e.g. patient harm) appears to have occurred, but there does not appear to have been a problem with the device or the way it was used.", + "output": "Adverse Event Without Identified Device or Use Problem (Finding)" + }, + { + "input": "Definition: Digitalis Glycosides described as alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.", + "output": "Desglucolanatosides C (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in mRNA polyadenylation.", + "output": "PAPD5 (Polymerase Gene)" + }, + { + "input": "Definition: Alkylating Agents described as the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.", + "output": "Dihydroxyanthracenedione Dihydrochloride (Immunotherapeutic agent)" + }, + { + "input": "Definition: Social Processes described as change in social status by an individual or a group.", + "output": "Mobility (Social Class)" + }, + { + "input": "Definition: something described as programmer/testers designed for noninvasively testing and/or changing the electrical characteristics (i.e., programming) of implanted vagus nerve stimulators. These devices typically consist of a computerized unit with programming, testing, and recording capabilities and a handheld telemetric wand capable of wirelessly sending and/or receiving data from the stimulator. Implantable vagus nerve stimulator programmer/testers are used to test and/or change the stimulation conditions (i.e., intensity or frequency of electrical stimulus) during patient checkup. These programmer/testers are usually appropriate only for a particular set of implantable vagus nerve stimulators.", + "output": "Programmer/Testers, Implantable Vagus Nerve Stimulator (Medical Device)" + }, + { + "input": "Definition: something described as human SFRP4 wild type allele is located in the vicinity of 7p14.1 and is approximately 11 kb in length. This allele, which encodes secreted frizzled-related protein 4, is involved in both the initiation of the Wnt protein-mediated signaling pathway, and the regulation of apoptotic gene expression.", + "output": "FRPHE (Gene or Genome)" + }, + { + "input": "Definition: Conceptual Entity described as the completed action for a product transportation event.", + "output": "PerformedProductTransport (Conceptual Entity)" + }, + { + "input": "Definition: Luo language described as a Southern Luo dialect spoken by the Acoli people in the districts of Gulu, Kitgum and Pader in northern Uganda. It is also spoken in southern Sudan in Magwi County of Eastern Equatoria state.", + "output": "Acoli (Luo language)" + }, + { + "input": "Definition: MMSE-2 Standard Version Functional Test Question described as mini-Mental State Examination 2 Standard Version (MMSE-2 Standard Version) Where are we now? What is the state (or province)?", + "output": "MMSE-2 Standard Version - What Is the State (Intellectual Product)" + }, + { + "input": "Definition: catabolism by symbiont of host carbohydrate described as the chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "catabolism by organism of host cell wall cellulose (catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "QS-EORTC QLQ-C30 Version 3 TEST (Intellectual Product)" + }, + { + "input": "Definition: something described as metalloreductase STEAP1 (339 aa, ~40 kDa) is encoded by the human STEAP1 gene. This protein plays a role at cell-cell junctions.", + "output": "Metalloreductase STEAP1 (Oxidoreductase)" + }, + { + "input": "Definition: Intellectual Product described as rivermead Post-Concussion Symptoms Questionnaire (RPQ) Compared with before the accident, do you now suffer from: Light sensitivity, easily upset by bright light.", + "output": "RPQ0114 (RPQ Questionnaire Question)" + }, + { + "input": "Definition: Inorganic Chemical described as lime water.", + "output": "Calcarea caustica, homeopathic preparation (Homeopathic remedies letter C)" + }, + { + "input": "Definition: Virus described as causes hantavirus pulmonary syndrome; transmitted by inhaling aerosolized rodent secretions; carried by Peromyscus species.", + "output": "Four Corners hantavirus (Virus)" + }, + { + "input": "Definition: something described as a molecular genetic abnormality indicating the presence of a mutation in exon 17 of the KIT gene located within 4q11-q12.", + "output": "c-KIT Exon 17 Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: organic substance metabolic process described as the chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.", + "output": "Lipid Metabolism (Molecular Function)" + }, + { + "input": "Definition: something described as atrophy of the superior cerebellar peduncle.", + "output": "Atrophic superior cerebellar peduncle (Finding)" + }, + { + "input": "Definition: Immunologic Tests described as methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.", + "output": "Mappings, Epitope (Immunologic Techniques)" + }, + { + "input": "Definition: Monophasic Synovial Sarcoma described as a synovial sarcoma characterized by the presence of an epithelial cell component only. The epithelial cells are arranged in glandular or papillary structures.", + "output": "synovial epithelioid cell sarcoma (Primary malignant neoplasm)" + }, + { + "input": "Definition: Name described as a non-unique textual identifier for the pathway. EXAMPLE(S): Notch signaling pathway OTHER NAME(S): NOTE(S):", + "output": "Pathway Name (Name)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions and duplications in genes associated with Walker-Warburg syndrome, a form of muscular dystrophy that also affects development of the brain and eyes. Genetic variants at multiple loci have been associated with Walker-Warburg syndrome. These reagents are intended to detect deletions and duplications in multiple Walker-Warburg syndrome-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy, Walker-Warburg Syndrome, Del/Dup (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as it is caused by mutations of gene encoding 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2).", + "output": "LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 1 (Disease or Syndrome)" + }, + { + "input": "Definition: Clinical Classification described as a standardized rating scale developed by Woodward et al and the Scottish Intercollegiate Guidelines Network (SIGN) in 2007, which is a classification system used to predict 10-year risk of cardiovascular disease.", + "output": "ASSIGN CVD 10-YEAR RISK (Clinical Classification)" + }, + { + "input": "Definition: Judaism described as a member of the Jewish faith whose ancestors lived in North Africa, the Middle East, Portugal or Spain.", + "output": "Sefardi Jewish religion (Religious Group)" + }, + { + "input": "Definition: stage, melanoma described as stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0). T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration. T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration. T2a: Melanoma 1.01-2.0 mm in thickness, no ulceration. N0: No regional lymph node metastasis. M0: No distant metastasis.-2003", + "output": "Stage I Cutaneous (Skin) Melanoma (stage, melanoma)" + }, + { + "input": "Definition: Cytokine Receptor Binding described as interacting selectively and non-covalently with the interleukin-3 receptor.", + "output": "interleukin-3 receptor binding (Molecular Function)" + }, + { + "input": "Definition: Disorder of abdomen described as downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.", + "output": "Descensus uteri (Pelvic prolapse conditions)" + }, + { + "input": "Definition: Stage II Testicular Cancer AJCC v8 described as stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay.", + "output": "Stage IIA Testicular Cancer (Neoplastic Process)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.", + "output": "ATP:pantothenate 4'-phosphotransferase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.", + "output": "negative regulation of RANKL production (negative regulation of tumor necrosis factor superfamily cytokine production)" + }, + { + "input": "Definition: Immunologic Factor described as a radioimmunoconjugate comprised of daclizumab, a recombinant humanized monoclonal antibody directed against the alpha subunit of the interleukin-2 (IL-2) receptor (IL-2RA, TAC antigen, CD25), which is labeled with the gamma-emitting isotope indium 111 (In 111; 111In), with potential radioimaging application. Upon administration, indium In 111 daclizumab targets and binds to IL-2RA and inhibits the binding of IL-2, thereby blocking IL-2-mediated activation of lymphocytes. IL-2RA is not expressed by normal resting lymphoid cells, with the exception of regulatory T-cells (Tregs), but it is expressed on a minority of Reed-Sternberg cells and, is overexpressed on T-cells rosetting around Reed-Sternberg cells in certain lymphomas. The use of gamma scintigraphy permits the immunodetection of IL-2RA expressing cells.", + "output": "Indium In 111 Daclizumab (Pharmacologic Substance)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the neutrophilic myelocytes in a biological specimen.", + "output": "Neutrophilic Myelocytes (Laboratory Procedure)" + }, + { + "input": "Definition: something described as suicidal Ideation Questionnaire-Junior (SIQ-JR) Critical item 5.", + "output": "SIQ-JR - Critical Item 5 (Intellectual Product)" + }, + { + "input": "Definition: something described as the modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone.", + "output": "histone H3 K37 methylation (histone lysine methylation)" + }, + { + "input": "Definition: Virus described as any viral organism that can be assigned to the genus Norovirus.", + "output": "Norwalk-like virus (Virus)" + }, + { + "input": "Definition: something described as a congenital heart malformation characterized by abnormalities in the anatomic structures that relate to the endocardial cushions. These abnormalities can include defects in the lower part of the atrial septum and the ventricular septum and lack of separation of the mitral and tricuspid valves.", + "output": "defect; septum, atrioventricular (Heart)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's doctor made it clear that a decision needs to be made.", + "output": "Doctor Made Clear that a Decision Needs to be Made (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as transducin-like enhancer protein 4 (773 aa, ~84 kDa) is encoded by the human TLE4 gene. This protein plays a role in the repression of both transcription and signal transduction.", + "output": "Enhancer of Split Groucho 4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.", + "output": "protein retention in ER lumen (maintenance of protein localization in endoplasmic reticulum)" + }, + { + "input": "Definition: Oral Route of Drug administration described as administration of a soluble dosage form by placement under the tongue.", + "output": "ADMIN SUBLINGUAL (Oromucosal Route of Drug Administration)" + }, + { + "input": "Definition: Intellectual Product described as a standardized interviewer-administered or computer-adaptive testing (CAT) questionnaire that utilizes a 5-point rating scale to assess an individual's ability to perform activities in six domains of functioning over the 30 days prior to evaluation in order to calculate a global disability score. The questionnaire is initially administered as 12 items to screen for problematic domains of functioning. Up to 24 items are then added based on the initial responses. The questionnaire was developed in 2010 by the World Health Organization (WHO) Classification, Terminology and Standards team, within the framework of the WHO/National Institutes of Health (NIH) Joint Project on Assessment and Classification of Disability.", + "output": "WHODAS 2.0 - 12 + 24-ITEM INTERVIEWER (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Platelet clotting factor described as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).", + "output": "Thromboxane A>2< (Organic Chemical)" + }, + { + "input": "Definition: something described as the determination of the ability of urine to conduct an electrical current. This test is a non-linear function of the electrolyte concentration in the urine.", + "output": "CONDUCTU (Laboratory Procedure)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as the modes that may be applied to an entity as it passes through various phases of a life cycle or business process.", + "output": "SDTM-BRDGMOOD (Intellectual Product)" + }, + { + "input": "Definition: Endocrine System Diseases described as a benign or malignant neoplasm composed of cells of neuroendocrine origin. Representative examples include paraganglioma, carcinoid tumor, and neuroendocrine carcinoma.", + "output": "Neuroendocrine tumor NOS (Endocrine neoplasms malignant and unspecified NEC)" + }, + { + "input": "Definition: Stimulators, Electrical, Neuromuscular described as neuromuscular electrical stimulators that apply stimuli to the bladder wall or the pelvic floor to maintain urinary and/or fecal continence.", + "output": "Incontinence Control Units (Medical Device)" + }, + { + "input": "Definition: something described as heart sounds are auscultated on the precordial location corresponding to the blunt extremity of the heart formed by the left ventricle.", + "output": "Heart Sound Auscultation at Apex (Finding)" + }, + { + "input": "Definition: something described as perihilar bile duct cancer in which the regional lymph nodes cannot be assessed.", + "output": "Perihilar Bile Duct Cancer pNX TNM Finding v7 (Perihilar Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG described as molecular assay reagents intended to identify CAG repeats in the protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform (PPP2R2B) gene, located at chromosome 5q31-q33. Normal alleles have from 7 to 28 CAG trinucleotide repeats.A variation from the expected number of normal CAG trinucleotide repeat copies may produce altered DNA and improper gene functioning, resulting in full mutation. Alleles with from 66 to 78 CAG trinucleotide repeats have been associated with spinocerebellar ataxia type 12 (SCA12).", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, PPP2R2B Gene (Medical Device)" + }, + { + "input": "Definition: something described as an abnormally decreased amount of catalase level.", + "output": "Reduced catalase level (Finding)" + }, + { + "input": "Definition: something described as an indication as to whether consent requirements no longer need to be followed.", + "output": "Consents Waived Indicator (Functional Concept)" + }, + { + "input": "Definition: phosphoric diester hydrolase described as nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.", + "output": "Phosphodiesterases, 2',3'-Cyclic-Nucleotide (Enzyme)" + }, + { + "input": "Definition: Chimeric Antigen Receptor T-cells described as a preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a human monoclonal antibody specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused, via an as of yet unknown linker, to the co-stimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA CAR transduced T-cells KITE-585 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. The CD28 co-stimulatory domain optimizes T-cell expansion and function.", + "output": "autologous genetically-modified anti-BCMA CAR-T cells KITE-585 (Cell)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Dining out.", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Limit: Dining Out (Intellectual Product)" + }, + { + "input": "Definition: Abnormality of ocular abduction described as an impaired ability of the eye to move in the outward direction (towards the side of the head).", + "output": "Impaired ocular abduction (Eye)" + }, + { + "input": "Definition: Biologically Active Substance described as small proline-rich protein 2A (72 aa, ~8 kDa) is encoded by the human SPRR2A gene. This protein plays a role in keratinocyte differentiation.", + "output": "Small Proline-Rich Protein 2A (Structural protein)" + }, + { + "input": "Definition: photograph described as a digital photograph taken of a study participant for use in a clinical trial.", + "output": "Study Subj DigPic (Manufactured Object)" + }, + { + "input": "Definition: Intellectual Product described as a dataset used to represent non-standard variables and their association to parent records in the Subject Disease Milestones domain.", + "output": "Subject Disease Milestones Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: Finding described as problem associated with the device which has been used for an unapproved indication or for an unapproved intended use.", + "output": "Product, Incorrect (Device use issue)" + }, + { + "input": "Definition: something described as the development of the ear during the fourth week of gestation, with contributions from all three germ layers.", + "output": "Embryonic Ear (Subdivision of head of embryo)" + }, + { + "input": "Definition: Regimen Used to Treat Breast Carcinoma described as a chemotherapy regimen consisting of cyclophosphamide, fluorouracil, and prednisone that may be used in the treatment of advanced breast cancer.", + "output": "cyclophosphamide/fluorouracil/prednisone (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Finding described as endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms", + "output": "Grade 1 Tracheal Mucositis, CTCAE (Finding)" + }, + { + "input": "Definition: FACT-LEU Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Functional Well-Being: My work (include work at home) is fulfilling.", + "output": "FACT-LEU Version 4 - My Work Is Fulfilling (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine.", + "output": "choline formation via N-monomethylethanolamine (choline biosynthetic process)" + }, + { + "input": "Definition: Neoplastic Process described as stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage II Vulvar Carcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Laboratory Procedure described as applying a layer by condensing a vaporized coating material onto a cooled substrate within an evacuated chamber.", + "output": "Coating, Vapor Disposition (Laboratory Procedure)" + }, + { + "input": "Definition: Serine/Threonine Kinase Inhibitor described as an orally bioavailable inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, M 3541 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, M 3541 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.", + "output": "ATM Inhibitor M 3541 (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV includes: IVA (T4, N0-1, M0); IVB (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes. M0: No distant metastasis. M1: Distant metastasis.", + "output": "Stage IV Gallbladder Cancer AJCC v7 (Gallbladder Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: White blood cell count laboratory result described as abnormally high level of basophils in the blood.", + "output": "Circulating basophils increased above normal range (White blood cell analyses)" + }, + { + "input": "Definition: Virus described as a genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where the virions of most members have hemagglutinin but not neuraminidase activity. All members produce both cytoplasmic and intranuclear inclusion bodies. MEASLES VIRUS is the type species.", + "output": "morbilli virus (Morbillivirus)" + }, + { + "input": "Definition: Cell described as a preparation of Epstein-Barr virus (EBV) reactive cytotoxic T lymphocytes (CTLs) in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene is deleted, with potential immunomodulating activity. Upon administration of the PD-1 knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive cancer cells. This results in cell lysis and inhibition of cancer cell proliferation. Expression of PD-1, an inhibitory receptor expressed on activated T cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous human herpesvirus, is associated with various cancer cell types.", + "output": "PD-1 knockout Epstein-Barr Virus-Cytotoxic T-lymphocytes (Cell)" + }, + { + "input": "Definition: Panic attacks and disorders described as a state of extreme acute, intense anxiety and unreasoning fear accompanied by disorganization of personality function.", + "output": "panic; state (Anxiety)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format (IPAQ Long Last 7 Days Telephone Format Version) How much time did you usually spend on one of those days traveling in a car, bus, train or other kind of motor vehicle?: Hours per day.", + "output": "IPAQ Long Last 7 Days Telephone Format Version - Traveling Hours per Day (Intellectual Product)" + }, + { + "input": "Definition: Ectopic calcification described as deposition of calcium salts in gonadal tissue.", + "output": "Gonadal calcification (Ectopic calcification)" + }, + { + "input": "Definition: Health Care Activity described as actions performed to promote conception of the infertile client of an offspring/child", + "output": "Infertility Care (Health Care Activity)" + }, + { + "input": "Definition: something described as a protozoan parasite from Southeast Asia that causes monkey malaria. It is naturally acquired by man in Malaysia and can also be transmitted experimentally to humans.", + "output": "Plasmodium knowlesus (Eukaryote)" + }, + { + "input": "Definition: something described as invasive intervention indicated", + "output": "Grade 3 Pharyngeal fistula (Finding)" + }, + { + "input": "Definition: something described as records of communications related to a centralized test.", + "output": "Relevant Communications (Document type)" + }, + { + "input": "Definition: Finding described as increased level of IgE antibody against seafood, including fish, shrimp, lobster, crab, squid and abalone.", + "output": "Increased level of anti-seafood IgE antibody (Finding)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus.", + "output": "cellular response to nicotinamide (Cell Function)" + }, + { + "input": "Definition: Alveolata described as flagellate EUKARYOTES, found mainly in the oceans. They are characterized by the presence of transverse and longitudinal flagella which propel the organisms in a rotating manner through the water. Dinoflagellida were formerly members of the class Phytomastigophorea under the old five kingdom paradigm.", + "output": "dinophytes (Eukaryote)" + }, + { + "input": "Definition: transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA.", + "output": "caffeoyl-CoA: alcohol caffeoyl transferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: Squamous cell carcinoma of tongue described as sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation.", + "output": "spindle cell carcinoma of tongue (Neoplastic Process)" + }, + { + "input": "Definition: something described as any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.", + "output": "positive regulation of epithelial cell proliferation involved in prostate gland development (positive regulation of reproductive process)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 418 of the coding sequence of the IDH2 gene where cytosine has been mutated to guanine.", + "output": "Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial c.418C>G (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of CD161 expressing cells to all lymphocytes in a biological specimen.", + "output": "CD161/Lymphocytes (Laboratory Procedure)" + }, + { + "input": "Definition: cytokine binding described as interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.", + "output": "IFN binding (Molecular Function)" + }, + { + "input": "Definition: Reexploration procedure described as surgery performed after cancer treatment to assess the results of prior treatment and to plan possible future treatment.", + "output": "Incision and re-exploration, second look (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Gene or Genome described as human FGF9 wild-type allele is located within 13q11-q12 and is approximately 30 kb in length. This allele, which encodes fibroblast growth factor 9 protein, is involved in cellular growth, proliferation, glial cell development, and the negative regulation of apoptosis.", + "output": "SYNS3 (FGF9 gene)" + }, + { + "input": "Definition: something described as this gene is involved in both telomere maintenance and ribosomal RNA (rRNA) stability.", + "output": "NOLA2 (Telomere Maintenance Gene)" + }, + { + "input": "Definition: Serum, Urine and Miscellaneous Proteins described as a thyroid hormone transport protein found in serum. It binds about 75% of circulating THYROXINE and 70% of circulating TRIIODOTHYRONINE.", + "output": "Thyropexin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Solanaceae described as a plant genus of the family SOLANACEAE. Members contain steroidal glycosides.", + "output": "Petunia Juss. (Plant)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant hemangiopericytoma with well-differentiated morphological features.", + "output": "Well Differentiated Malignant Hemangiopericytoma (Neoplastic Process)" + }, + { + "input": "Definition: MUSCLE SOFT, TISSUE described as fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches.", + "output": "Fibre splitting (Finding)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of secretory granule organization.", + "output": "regulation of secretory granule organization (regulation of organelle organization)" + }, + { + "input": "Definition: Pharmacologic Substance described as an ethacrynic acid derivative with diuretic activity.", + "output": "Brocrinat (Organic Chemical)" + }, + { + "input": "Definition: Serine/Threonine Protein Kinase Gene described as this gene is involved in the regulation of mitosis.", + "output": "PLK3 gene (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as terminology related to the non-clinical respiratory test code codelist.", + "output": "SEND Respiratory Test Code (CDISC SEND Terminology)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein encoded by the NRXN2 gene.", + "output": "NRXN2 Gene Product (Biologically Active Substance)" + }, + { + "input": "Definition: Device Component or Accessory described as instruments designed to access, examine, diagnose, and/or treat internal tissues and/or organs of the human body otherwise inaccessible through natural canals or body cavities. These instruments usually consist of an outer sheath, a lighting system (e.g., fiberoptic), and a working channel to introduce catheters and operative devices. Endoscopes may be flexible or rigid, using plastic or metallic (e.g. stainless steel) outer sheaths; some include a video camera to display images from the tip of the endoscope. Most endoscopes are specialized for the area where they operate and/or the procedure to be performed; they are named accordingly.", + "output": "Endoscope Device (Imaging Device)" + }, + { + "input": "Definition: Subcellular structure described as it is the aggregated products of microtubules during mitosis where chromosomes line up prior to the segregation process. Many antineoplastic agents cause cytotoxicity by inducing microtubular bundle formation irreversibly.", + "output": "microtubule bundle (Subcellular structure)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized 7-item patient-reported outcome instrument, created by McCarrier et al. in 2016, that utilizes a 7-day recall period and a five-point verbal rating scale to assess symptoms of non-small cell lung cancer.", + "output": "NSCLC-SAQ V1.0 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Pharmacologic Substance described as a derivative of lovastatin and inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG coA reductase), a rate limiting enzyme in the biosynthesis of cholesterol.", + "output": "[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate (Chemical categorised functionally)" + }, + { + "input": "Definition: Ventricular and Brain Stem Ependymal Tumor described as an ependymal tumor affecting the fourth ventricle and the brain stem.", + "output": "Fourth Ventricle and Brain Stem Ependymal Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in sterol-mediated transcription.", + "output": "CNBP1 (Transcription factor genes)" + }, + { + "input": "Definition: Cell Function described as any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus.", + "output": "oxidative stress-induced neuron death (cell death in response to oxidative stress)" + }, + { + "input": "Definition: something described as serology reagents intended to detect antibody titers or antigens of Borrelia burgdorferi, a species of intracellular bacterium of the family Spirochaetaceae. These bacteria cause Lyme disease (i.e., Lyme borreliosis), acrodermatitis chronica atrophicans, and erythema chronicum migrans; they are typically transmitted by a parasitic tick of the genus Ixodes.", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Borrelia burgdorferi (Medical Device)" + }, + { + "input": "Definition: negative regulation of post-embryonic development described as any process that stops, prevents or reduces the frequency, rate or extent of seed maturation.", + "output": "negative regulation of seed maturation (regulation of seed maturation)" + }, + { + "input": "Definition: Pharmacologic Substance described as a derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most common use is as a general anesthetic in animal experiments.", + "output": "alpha-Chloralose (Organic Chemical)" + }, + { + "input": "Definition: Unit of volume described as a unit of volume equal to one trillionth of a liter (10E-12 liter).", + "output": "pL (SI-derived unit of volume)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the cells containing Pappenheimer Bodies (violet or blue staining ferritin granules usually found along the periphery of the red blood cells) in a biological specimen.", + "output": "Pappenheimer Body Count (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a rare developmental defect during embryogenesis with the specific association of glandular hypospadias and lumbo-sacral spina bifida. Affected individuals may or may not present additional congenital anomalies, such as hydrocephaly, microstomia, patent ductus arteriosus, cryptorchidism, intestinal malrotation, rocker-bottom feet and hypertrichosis.", + "output": "Spina bifida and hypospadias syndrome (Hypospadias, balanic)" + }, + { + "input": "Definition: Proteins described as albumin found in milk.", + "output": "lactalbumin (Milk Proteins)" + }, + { + "input": "Definition: Gallbladder Biliary Intraepithelial Neoplasia described as biliary intraepithelial neoplasia that affects the gallbladder epithelium. It is characterized by the presence of intraluminal micropapillary projections.", + "output": "Gallbladder Papillary Intraepithelial Neoplasia (Neoplastic Process)" + }, + { + "input": "Definition: Cell Function described as the process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away.", + "output": "zygospore formation (sexual sporulation resulting in formation of a cellular spore)" + }, + { + "input": "Definition: Reference Date Time described as the date and time of a laboratory test reference point.", + "output": "Laboratory Test Date Time of Reference Timepoint (Temporal Concept)" + }, + { + "input": "Definition: something described as terminology that represents methods of evaluation used by the CDRH with respect to reporting Medical Device events.", + "output": "FDA Manufacturer Evaluation Method Code Hierarchy (Intellectual Product)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH.", + "output": "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: something described as a protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase.", + "output": "alphaV-beta3 integrin-tissue transglutaminase complex (Cell Component)" + }, + { + "input": "Definition: Anti-Bacterial Agents described as a broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, particularly PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and eventually lysis of the bacterial cell wall. This agent is two- to 16-fold more potent than imipenem and comparable to ertapenem and meropenem.", + "output": "DORIPENEM (D [Preparations])" + }, + { + "input": "Definition: something described as DDB1- and CUL4-associated factor 12-like protein 2 (463 aa, ~51 kDa) is encoded by the human DCAF12L2 gene. This protein plays a role in the modulation of protein-protein interactions.", + "output": "DCAF12L2 (Binding Proteins)" + }, + { + "input": "Definition: Molecular Function described as the methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine.", + "output": "N-terminal peptidyl-phenylalanine methylation (peptidyl-phenylalanine modification)" + }, + { + "input": "Definition: Count described as an administrative activity defined at a global library level that represents the action of producing a set of quantitative information (counts of objects), and which, when gathered and recorded over a period of time, reflects the progress of a goal.", + "output": "DefinedProgressCount (Quantitative Concept)" + }, + { + "input": "Definition: Qualitative Concept described as not as a direct effect or consequence; having intervening factors or persons or influences.", + "output": "Indirect (Relationships)" + }, + { + "input": "Definition: something described as a fusion protein encoded by the BCR/ABL1 fusion gene with ABL1 NM_005157.4:c.827A>G mutation. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein where the aspartic acid at position 276 of the ABL1 protein has been replaced by glycine.", + "output": "D276G (Fusion Proteins, bcr-abl)" + }, + { + "input": "Definition: something described as the stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc.", + "output": "O-glycan processing, core 7 (O-glycan processing)" + }, + { + "input": "Definition: regulation of glucose transmembrane transport described as any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.", + "output": "regulation of glucose uptake (regulation of glucose transmembrane transport)" + }, + { + "input": "Definition: something described as a germ cell tumor that arises from the ovary and is composed of tissues that originate from two or three of the following germ layers, endoderm, ectoderm, or mesoderm.", + "output": "Ovarian Biphasic or Triphasic Teratoma (Ovarian Teratoma)" + }, + { + "input": "Definition: Organic Chemical described as common houseleek.", + "output": "sempervivum tectorum/common (Organic Chemical)" + }, + { + "input": "Definition: General site descriptor described as in human anatomy, has to do with the back of a structure, or a structure found toward the back of the body.", + "output": "Back of (Topographical modifier)" + }, + { + "input": "Definition: something described as a complex that possesses protein histidine kinase activity.", + "output": "protein histidine kinase complex location (protein kinase complex)" + }, + { + "input": "Definition: Intellectual Product described as symptoms of Major Depressive Disorder Scale v1.0 - Over the past 7 days, how much of the time did you blame yourself when bad things happened?", + "output": "SMDDS Version 1.0 - How Much Blame Yourself Bad Thing (SMDDS Version 1.0 Questionnaire Question)" + }, + { + "input": "Definition: Finding related to use of protection for sex described as sexual intercourse without the use of precautions to prevent conception or the transmission of sexually transmitted diseases.", + "output": "Unprotected Intercourse (Use of protection for sex)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation.", + "output": "cellular response to bacteriocin (cellular response to antibiotic)" + }, + { + "input": "Definition: something described as type C is a rare form. Its genetic defect is not clear; appears to be a heterogeneous group. OMIM suggests that Type C should not be used anymore.", + "output": "Cockayne Syndrome, Type III (Cockayne Syndrome)" + }, + { + "input": "Definition: something described as a European Norm (EN) that has been accepted by all Member States and has been published in the Official Journal of the European Communities (OJEC).", + "output": "harmonized standard (Standard)" + }, + { + "input": "Definition: extrinsic component of vacuolar membrane described as the component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", + "output": "extrinsic to lysosomal membrane (extrinsic component of vacuolar membrane)" + }, + { + "input": "Definition: something described as an adverse event in a newborn characterized by local irritation or a complication at the administration site of a drug.", + "output": "Administration site reaction neonatal (Finding)" + }, + { + "input": "Definition: T-Cell Lymphoma described as a group of mature T-cell and NK-cell non-Hodgkin lymphomas that includes enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, and intestinal T-cell lymphoma, not otherwise specified. Most of these lymphomas arise from the small intestine and a minority from the large intestine or stomach.", + "output": "Intestinal T-cell lymphomas (Lymphoma, Non-Hodgkin)" + }, + { + "input": "Definition: Cerebral cortex myoclonus described as a rare genetic movement disorder with characteristics of autosomal dominant, adult-onset, slowly progressive, multifocal, cortical myoclonus. Patients present somatosensory-evoked, brief, jerky, involuntary movements in the face, arms and legs, associated in most of cases with sustained, multiple, sudden falls without loss of consciousness. Seizures or other neurological deficits, aside from mild cerebellar ataxia late in the course of the illness, are absent. The disease is caused by heterozygous mutation in the NOL3 gene on chromosome 16q22.", + "output": "MYOCLONUS, FAMILIAL CORTICAL (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as the process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.", + "output": "serine phosphorylation of STAT protein (Molecular Function)" + }, + { + "input": "Definition: Homeopathic remedies letter H described as lobster digestive fluid.", + "output": "Homarus americanus / lobster digestive fluid (Organic Chemical)" + }, + { + "input": "Definition: something described as a group of TETRAHYDRONAPHTHALENES containing a keto oxygen.", + "output": "Tetralones (Tetrahydronaphthalenes)" + }, + { + "input": "Definition: FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 (FACT-P Version 4) Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family.", + "output": "FAC02303 (Intellectual Product)" + }, + { + "input": "Definition: Plasmablastic Lymphoma of the Oral Mucosa described as a plasmablastic oral mucosa lymphoma in a patient with acquired immunodeficiency syndrome.", + "output": "AIDS-Related Plasmablastic Lymphoma of Oral Mucosa (AIDS-Related Plasmablastic Lymphoma of Mucosa Site)" + }, + { + "input": "Definition: Triangular shaped phalanges of the hand described as abnormality of the phalanges of the 2nd (index) finger.", + "output": "Abnormality of 2nd finger phalanges (Anatomical Abnormality)" + }, + { + "input": "Definition: Qualitative Concept described as specifies whether this is the main or principal subject identifier.", + "output": "Subject Identifier Primary Indicator (Primary Indicator)" + }, + { + "input": "Definition: Anomaly of chromosome pair 7 described as a rare chromosomal anomaly syndrome with a highly variable phenotype. Principle characteristics are growth failure, short stature, intellectual disability, dermatological abnormalities (nevus flammeus, dark pigmented nevi, cafe au lait spots), microcephaly and facial dysmorphism (including facial asymmetry, small ears, abnormal palpebral fissures, ptosis, epicanthic folds, hyper/hypotelorism). Additional reported features include convulsions, cleft lip and palate, clinodactyly, kyphoscoliosis and genital anomalies (cryptorchidism, hypospadias, micropenis).", + "output": "chromosome 7 ring syndrome (Chromosome replaced with ring or dicentric)" + }, + { + "input": "Definition: female testing described as providing a basic analysis of a female client/patient's saliva sample to assess her post-menopausal estradiol, estrone, estriol, progesterone and/or testosterone levels. Service is billed per test.", + "output": "Basic post-menopause profile each test (female testing)" + }, + { + "input": "Definition: Hormones described as a type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone can also be made in the laboratory. It may be used as a type of birth control and to treat menstrual disorders, infertility, symptoms of menopause, and other conditions.", + "output": "17alpha-Progesterone (Therapeutic Steroid Hormone)" + }, + { + "input": "Definition: Cleft Palate described as a rare genetic developmental defect during embryogenesis syndrome with characteristics of the association of complete, partial or submucous cleft palate and ankyloglossia. Patients may also present abnormal uvula (for example absent, bifid, shortened or laterally deviated), short lingual frenulum and dental anomalies (for example buccal crossbite, absent and/or misshapen teeth). Digital abnormalities, such as mild clinodactyly and/or syndactyly, have also been reported.", + "output": "X-linked cleft palate and ankyloglossia (Ankyloglossia)" + }, + { + "input": "Definition: Fungus described as any fungal organism that is not assigned to the species level but can be assigned to the Curvularia genus level.", + "output": "Curvularia (Form family Dematiaceae)" + }, + { + "input": "Definition: Pharmacologic Substance described as a sterol derivative of cholesterol with two nitrogen atoms replacing two carbon atoms that acts as a hypocholesteremic agent by blocking delta-24-reductase. Azacosterol has the unintended side effect of causing myotonia.", + "output": "IMD 760 (Antilipidemic Agent)" + }, + { + "input": "Definition: Structure of intercostal space described as intercostal compartment space between first and second ribs.", + "output": "Structure of first intercostal space (Structure of intercostal space)" + }, + { + "input": "Definition: something described as a plant genus of the family SAPOTACEAE. Members contain triterpenes. Some species in this genus are called mamey which is also a common name for MAMMEA.", + "output": "Pouteria Aubl., 1775 (Chrysophylloideae)" + }, + { + "input": "Definition: pre-mRNA binding described as interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence.", + "output": "pre-mRNA 3'-splice site binding (Genetic Function)" + }, + { + "input": "Definition: Spatial Concept described as one of the four primary cardinal directions. South is at 180 degree on a compass card. It is the direction to the right of sunrise.", + "output": "South (Spatial Concept)" + }, + { + "input": "Definition: eye circulation described as vessels, supply, and flow of blood through the vascular system of the retina.", + "output": "retina circulation (eye circulation)" + }, + { + "input": "Definition: Carrier Proteins described as neutral and basic amino acid transport protein rBAT (685 aa, ~79 kDa) is encoded by the human SLC3A1 gene. This protein is involved in the mediation of amino acid transport.", + "output": "RBAT protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Cell Function described as the process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.", + "output": "ensheathment of neurons (cellular process)" + }, + { + "input": "Definition: Family Caregiver Performance described as adaptive response of family caregiver when the care recipient is moved to an institution", + "output": "Caregiver adaptative behavior: patient institutionalisation (Finding)" + }, + { + "input": "Definition: stage, Merkel cell carcinoma described as stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0). T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension. T3: Primary tumor over 5 cm in maximum dimension. T4: Primary tumor invades bone, muscle, fascia, or cartilage. pN0: No regional lymph node metastasis by pathologic examination. cN0: No regional lymph node metastasis by clinical examination. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "stage II neuroendocrine carcinoma of the skin (stage, Merkel cell carcinoma)" + }, + { + "input": "Definition: something described as a neoplasm of the choroid plexus occurring in adults.", + "output": "tumor, adult choroid plexus (Choroid Plexus Neoplasms)" + }, + { + "input": "Definition: T [Preparations] described as an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity. Upon oral administration, E7438 selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in EZH2 mutated cancer cells. EZH2, which belongs to the class of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of cancer cells and plays a key role in tumor cell proliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C107506\" active clinical trials using this agent.", + "output": "Product containing tazemetostat (Antineoplastic Agents)" + }, + { + "input": "Definition: Organic Chemical described as estrogen supplement drug used to relieve menopausal symptoms", + "output": "Climopax (Pharmacologic Substance)" + }, + { + "input": "Definition: Genetic Function described as a mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage.", + "output": "mitotic DNA damage checkpoint (Genetic Function)" + }, + { + "input": "Definition: Neoplastic Process described as a well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells.", + "output": "GANGLIONEUROFIBROMA (Neoplasms)" + }, + { + "input": "Definition: Neoplasm by Morphology described as a neoplasm which, on morphologic grounds, can not be classified with certainty as benign or malignant.", + "output": "Neoplasm, ?benign or malig (Neoplasms)" + }, + { + "input": "Definition: Person Role Title described as a courtesy title of respect applied or prefixed to the name of a member of the clergy or a religious order.", + "output": "Reverend (Professional or Occupational Group)" + }, + { + "input": "Definition: Motor Cortex described as anterodorsal areas of the cerebral cortex that are defined on the basis of internal structure, connectivity and function. It is one of two parts of the motor cortex; the other is the primary motor cortex ( Matelli-2004 ). In the human it is located in caudal parts of the superior frontal gyrus and middle frontal gyrus and in the rostral part of the precentral gyrus not occupied by the primary motor cortex; it is identified with area 6 of Brodmann (human). In the macaque it is located entirely in the precentral gyrus and, dorsally, in the caudal part of the superior frontal gyrus; it also identified with area 6 of Brodmann (guenon). In both it is subdivided into three parts: the mesial premotor cortex, dorsal premotor cortex, and ventral premotor cortex. In the rat ( Swanson-2004 ) and the mouse ( Hof-2000 ) the premotor cortex defined by absence of granular layers is not subdivided. It is the more medial of the two parts of the motor cortex located dorsolaterally in the anterior half of the cerebral cortex; at the frontal pole it occupies the entire dorsal aspect of the cortex; from there it gradually narrows to its caudal extreme, where it occupies a narrow band on the dorsal surface along the midline. The premotor cortex is not ordinarily subdivided in brain atlases of rodents.", + "output": "Premotor Area (Inferior frontal gyrus)" + }, + { + "input": "Definition: Entire artery of upper extremity described as the continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.", + "output": "arteries axillary (Artery of upper extremity)" + }, + { + "input": "Definition: ECG Measurement described as a QT single beat interval that is corrected for heart rate using Bazett's formula, based on a QT interval measured on a single beat utilizing one or more ECG leads.", + "output": "Single Beat QTCB Interval (Quantitative Concept)" + }, + { + "input": "Definition: high energy compound described as glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety.", + "output": "nucleoside triphosphate (high energy compound)" + }, + { + "input": "Definition: psychopharmacologic agent described as chemical agent that arouses or accelerates learning.", + "output": "learning stimulant (psychopharmacologic agent)" + }, + { + "input": "Definition: Isomerase Gene described as this gene is involved in the regulation of both DNA topology and transcription.", + "output": "TOPOISOMERASE, DNA, I (Isomerase Gene)" + }, + { + "input": "Definition: Cranial nerve diseases described as a non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve).", + "output": "Second cranial nerve disorder (Disorder of the optic nerve)" + }, + { + "input": "Definition: something described as a sterile ophthalmic solution containing 0.03% of a synthetic prostaglandin analog bimatoprost with hair-growing and anti-glaucoma activities. Applied once daily to the upper eyelid margin at the base of the eyelashes and, optionally, to the eyebrows, bimatoprost penetrates into the hair follicle and may, through a mechanism that has yet to be fully understood, stimulate the transition of hair follicles from the telogen phase into the anagen phase and may increase the duration of the time follicles spend in anagen. By increasing the numbers of hair follicles in and duration of anagen phase, bimatoprost may help increase eyebrow and eyelash growth and appearance, including their length, thickness and darkness. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88294\" active clinical trials using this agent.", + "output": "bimatoprost ophthalmic solution (Clinical Drug)" + }, + { + "input": "Definition: something described as breast cancer with micrometastases (approximately 200 cells, larger than 0.2 mm, but none larger than 2.0 mm).", + "output": "Breast Cancer pN1mi TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as the use of a laser to break apart the ink in a tattoo, which is then reabsorbed and the tattoo dissolves.", + "output": "Laser Tattoo Removal (Cosmetic surgery)" + }, + { + "input": "Definition: Biopsy of retroperitoneum described as removal of tissue from the pancreas for microscopic examination.", + "output": "Biopsy of pancreas, NOS (Diagnostic procedure by site)" + }, + { + "input": "Definition: Professional or Occupational Group described as employees who have direct contact with the public; generally nonprofessional and nonsales personnel. Includes hotel, airline, and restaurant personnel, but does not include health care personnel.", + "output": "SERVICE PERSONNEL (Occupational Groups)" + }, + { + "input": "Definition: regulation of renal output by angiotensin described as the process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney.", + "output": "negative regulation of renal output by angiotensin (regulation of renal output by angiotensin)" + }, + { + "input": "Definition: Intellectual Product described as melanoma is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology.", + "output": "Melanoma (Intellectual Product)" + }, + { + "input": "Definition: something described as a genetic marker that distinguishes regulatory T-cells (Tregs) from other T-lymphocytes. This marker is comprised of a demethylated CpG motif that is within the 5' untranslated region of the FOXP3 gene, which is only found in Tregs. This CpG motif is methylated in other T-cell lineages. The methylation status of this region of the FOXP3 gene may influence the expression of the transcription factor, forkhead box protein P3.", + "output": "FOXP3 Treg-Specific Demethylated Region (T-Cell Marker)" + }, + { + "input": "Definition: Cell Growth Processes described as the complex series of phenomena occurring after cell division and before cell death.", + "output": "growth of cell (Growth)" + }, + { + "input": "Definition: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor described as catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+).", + "output": "hydroxybenzoquinone reductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the observed volume of distribution associated with the terminal slope following intravascular administration divided by the body mass index.", + "output": "VZOB (Observed Volume of Distribution)" + }, + { + "input": "Definition: something described as stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). M1b: Metastases in more than one organ/site or the peritoneum.", + "output": "Stage IV Colorectal Cancer AJCC v7 (Colorectal Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: Embryonic Structure described as the outer of the three germ layers of an embryo.", + "output": "Ectoderms (Histogenic layer)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of lipoprotein oxidation.", + "output": "regulation of lipoprotein oxidation (regulation of lipoprotein metabolic process)" + }, + { + "input": "Definition: something described as coagulant substances inhibiting the anticoagulant action of heparin.", + "output": "heparin antagonist (Coagulants)" + }, + { + "input": "Definition: Narcotic Analgesics described as a narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.", + "output": "LEVORPHANOL (Opioid Receptor Agonist)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the IgM antibody from any member of the genus Coccidioides in a biological specimen.", + "output": "Coccidioides IgM Antibody Measurement (Immunoglobulin M measurement)" + }, + { + "input": "Definition: LITHIUM SALTS described as a lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.", + "output": "Carbonic acid, dilithium salt (Lithium Compounds)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.", + "output": "response to dithiothreitol (response to oxygen-containing compound)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the PIK3CA gene that that results in constitutive activation of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and its downstream signaling pathways.", + "output": "PIK3CA Activation Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Sequence described as a serially recurrent arrangement of radiofrequency pulses that are applied to the sample.", + "output": "PULSSEQ (Sequence)" + }, + { + "input": "Definition: Medical Device described as this is an external ultrasound device that will be used simultaneously with IV tPA to recanalize eschemic stroke patients. The idea is that by combining ultrasound with the tPA you will achieve earlier recanalization and possibly improvve clinical outcomes.", + "output": "ULTRASOUND, THROMBOLYSIS SYSTEM (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as a bioactive sphingolipid comprised of a sphingosine with a phosphate group attached to the carbon at position 1. Sphingosine 1-phosphate (S1P) binds to G protein-coupled S1P receptors (S1PRs) and initiates signaling pathways involved in the regulation of angiogenesis, the proliferation of skin cells, vascular stability and permeability, and T- and B-cell trafficking.", + "output": "(2S,3R,4E)-2-Amino-3-Hydroxyoctadec-4-En-1-Yl Dihydrogen Phosphate (Organic Chemical)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a murine monoclonal antibody (MoAb) with application in Immunotherapy and radioimmunodetection in T-cell malignancies. MoAb T101 recognizes a 65kD glycoprotein, CD5 antigen, on the surface of T-cells. When radiolabeled, this MoAb has potential use in the radioimaging or may induce a cytotoxic T-cell response against CD5+ T cells.", + "output": "T101 monoclonal antibody (Monoclonal Antibodies)" + }, + { + "input": "Definition: Lipid cell tumor of ovary described as a steroid cell tumor that arises from the ovary and is defined by morphologic features that do not fit into the categories of Leydig cell tumor and stromal luteoma. These features include solid proliferations of polygonal neoplastic cells with eosinophilic and granular cytoplasm. Grossly, these tumors usually present as large and well circumscribed masses and are usually associated with androgenic manifestations. Approximately one third of the cases have a malignant clinical course.", + "output": "Ovarian Steroid Cell Tumor, Not Otherwise Specified (Lipid cell tumor of ovary)" + }, + { + "input": "Definition: Chronic leukemia described as a disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. Chronic eosinophilic leukemia may stay the same for many years, or it may progress quickly to acute leukemia.", + "output": "Eosinophilic Leukemia (Myeloid Leukemia, Chronic)" + }, + { + "input": "Definition: New England described as a state in the northeast United States. Its capital is Boston.", + "output": "MA (US State)" + }, + { + "input": "Definition: Medical Device described as laryngoscopes designed with a nonflexible (i.e., rigid) structure that can only follow a straight path through the airway. They are constructed of metal and contain straight or curved blades for manipulation of the tongue and pharynx during the procedures. Rigid endoscopes are frequently used for insertion of endotracheal tubes.", + "output": "Laryngoscopes, Rigid (Laryngoscopes)" + }, + { + "input": "Definition: Myxotrichaceae described as a genus of soil fungi in the family Myxotrichaceae with dark, erect conidiophores that terminate in an irregular system of tree-like branches . Species within the genus are commonly isolated from wood, wood pulp, and soil. They are not known to pose a health hazard to humans.", + "output": "Oidiodendron, NOS (Fungus)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as treatment with chemotherapy drugs at levels that will also destroy the bone marrow, followed by infusion of stem cells to reconstitute the immune system.", + "output": "High-Dose Chemotherapy with Autologous Stem Cell Transplant (Stem cell therapy)" + }, + { + "input": "Definition: Hepatobiliary Disorder described as cancer that forms in a bile duct. A bile duct is a tube that carries bile (fluid made by the liver that helps digest fat) between the liver and gallbladder and the intestine. Bile ducts include the common hepatic, cystic, and common bile ducts. Bile duct cancer may be found inside the liver (intrahepatic) or outside the liver (extrahepatic).", + "output": "Bile Duct Cancer (Hepatobiliary Disorder)" + }, + { + "input": "Definition: Injury, Poisoning and Procedural Complications, CTCAE described as a finding of sudden movement downward, usually resulting in injury.", + "output": "Fall, CTCAE (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: Medical Device described as surgical forceps designed to grasp and manipulate during laparoscopic procedures. These forceps are typically handheld instruments with scissor-like handles that may include a ratchet mechanism; a long slender shaft, and a single- or double-action distal tip, and rotating jaws (e.g., duck-bill, alligator) controlled by a knob on the handle. Laparoscopic forceps are introduced through a laparoscope in the abdominal or pelvic cavities to grasp internal structures to facilitate observation, excision, or biopsy procedures.", + "output": "Forceps, Laparoscopic (Medical Device)" + }, + { + "input": "Definition: regulation of post-embryonic development described as any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification.", + "output": "regulation of imaginal disc-derived wing vein specification (regulation of animal organ morphogenesis)" + }, + { + "input": "Definition: something described as terminology associated with the schizophrenia findings about test code codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "CDISC SDTM Schizophrenia Findings About Test Code Terminology (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Regimen Used to Treat Non-Hodgkin Lymphoma described as a chemotherapy regimen consisting of chlorambucil that may be used in the treatment of chronic lymphocytic leukemia (CLL), small lymphocytic leukemia (SLL),and follicular lymphoma (grade 1-2).", + "output": "Leukeran Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as chronic myelomonocytic leukemia not growing; responding to treatment.", + "output": "Chronic Myelomonocytic Leukemia in Remission (Leukemia, Myelomonocytic, Chronic)" + }, + { + "input": "Definition: Substance with tetracycline structure described as a drug used to treat bacterial infections. It stops the growth of bacteria by keeping them from making proteins. Tetracycline also binds to new bone tissue and is being studied as a way to detect bone growth. Tetracycline is a type of antibiotic and a type of bone-labeling agent.", + "output": "TCN (skin antibiotic)" + }, + { + "input": "Definition: Proteins described as a 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.", + "output": "B2GP1 (Glycoproteins)" + }, + { + "input": "Definition: Cells described as a cell in a resting state. Individual chromosomes are not visible. The cell performs all biochemical and physiologic functions and replication of chromatin occurs.", + "output": "Interphase Cell (Cells)" + }, + { + "input": "Definition: something described as teachers and instructors not specifically identified elsewhere.", + "output": "Other teachers/instructors (Education profession)" + }, + { + "input": "Definition: Ear structure described as partial or complete loss of hearing following ingestion of aminoglycoside antibiotics.", + "output": "Hearing loss, aminoglycoside-induced (Ear structure)" + }, + { + "input": "Definition: Delirium, Dementia, Amnestic, Cognitive Disorders described as the organic and psychogenic disturbances observed after closed head injuries (HEAD INJURIES, CLOSED). Post-concussion syndrome includes subjective physical complaints (i.e. headache, dizziness), cognitive, emotional, and behavioral changes. These disturbances can be chronic, permanent, or late emerging.", + "output": "Postconcussional syndrome (Neurological signs and symptoms NEC)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine.", + "output": "Stage IV Ovarian Cancer (Ovarian Cancer by AJCC v8 Stage)" + }, + { + "input": "Definition: Intellectual Product described as extended Glasgow Outcome Scale (GOSE) Are they able to travel locally without assistance?", + "output": "GOSE104A (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Additional Concerns: I have diarrhea (diarrhoea).", + "output": "FACT-HEP Version 4 - I Have Diarrhea (Intellectual Product)" + }, + { + "input": "Definition: something described as any part of the anatomy, other than the incision, which was opened or manipulated during an operation.", + "output": "Surgical Organ or Space (Anatomic Site)" + }, + { + "input": "Definition: Ego Development described as the experience of the self as a recognizable entity resulting from one's ego ideal, behavior and social roles, and adjustments to reality.", + "output": "ego identity (Mental Process)" + }, + { + "input": "Definition: something described as a large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.", + "output": "Mediator Transcription Complex (Nuclear Proteins)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in serine/threonine phosphorylation of protein substrates.", + "output": "LIMK2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Receptor described as frizzled-6 (706 aa, ~79 kDa) is encoded by the human FZD6 gene. This protein plays a role in G protein-coupled receptor signaling and Wnt binding.", + "output": "Frizzled Homolog 6 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Infant length described as a measurement from the high prominence of the head to the low prominence of the buttocks of a fetus or embryo during ultrasound. This measurement is useful in determining gestational age.", + "output": "CRL (Clinical Attribute)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the segment of the right hepatic duct located in the hilum of the liver.", + "output": "Hilar Portion of the Right Hepatic Duct (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Chromosome X Physical Location described as physical location of CDR1_Gene", + "output": "X: 139592243-139591945 (Chromosome X Physical Location)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 17q", + "output": "17q11.1 (Cell Component)" + }, + { + "input": "Definition: Completion Status described as a term used to describe the state or condition of the completeness of the morphology data.", + "output": "MOSTAT (Qualitative Concept)" + }, + { + "input": "Definition: something described as the process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "output": "midbrain-hindbrain boundary structural organization (Morphogenesis)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a monoclonal antibody directed against human CD20 with potential antineoplastic activity. Anti-CD20 monoclonal antibody TL011 specifically binds to the B cell-specific cell surface antigen CD20 antigen (MS4A1; membrane-spanning 4-domains, subfamily A, member 1), thereby potentially triggering an immune response against CD20-positive B cells, leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C94206\" active clinical trials using this agent.", + "output": "TL011 (Immunologic Factor)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as macrophage-capping protein (348 aa, ~39 kDa) is encoded by the human CAPG gene. This protein is involved in actin-based motility in non-muscle cells.", + "output": "Macrophage Capping Protein (Regulatory Protein)" + }, + { + "input": "Definition: Inorganic Chemical described as inorganic compounds that contain calcium as an integral part of the molecule.", + "output": "Calcium Compounds (Inorganic Chemicals)" + }, + { + "input": "Definition: Intellectual Product described as a document describing the batch retesting and analyses of the investigational product (IP).", + "output": "Investigational Product Retest and Expiry Document (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as the hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine.", + "output": "peptidyl-histidine hydroxylation (Molecular Function)" + }, + { + "input": "Definition: Nursing procedure described as actions performed to document condition by nurse", + "output": "rn status report (Act of Documentation)" + }, + { + "input": "Definition: Complete duplication of phalanx of hand described as a complete duplication affecting one or more of the phalanges of the 2nd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.", + "output": "Complete duplication of the phalanges of the 2nd finger (Congenital Abnormality)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the paired immunoglobulin fragments composed of the variable domains of the heavy and light chains.", + "output": "Fragment, Fv (Immunologic Factor)" + }, + { + "input": "Definition: something described as a multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.", + "output": "ribosome quality control complex location (Cell Component)" + }, + { + "input": "Definition: Finding described as up and around, but minimal active play; keeps busy with quieter activities.", + "output": "Lansky Performance Status 60 (Finding)" + }, + { + "input": "Definition: something described as a neuro-ophthalmologist is a subspecialist of ophthalmology. This physician evaluates, treats, and studies disorders of the eye, orbit and nervous system having to do with interactions of the visual motor and visual sensory systems with the central nervous system. Neuro-ophthalmologists manage patients with complex and severe neuro-ophthalmological disorders.", + "output": "Allopathic & Osteopathic Physicians; Ophthalmology, Neuro-ophthalmology (Professional or Occupational Group)" + }, + { + "input": "Definition: C-SSRS Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Since Last Visit - Most lethal attempt date.", + "output": "C-SSRS Since Last Visit - Most Lethal Attempt Date (Intellectual Product)" + }, + { + "input": "Definition: something described as a chromosome band present on 10q", + "output": "10q25.3 (Chromosome band)" + }, + { + "input": "Definition: cell surface receptor signaling pathway involved in heart development described as the series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.", + "output": "Wnt signaling pathway involved in heart development (Wnt Signaling Pathway)" + }, + { + "input": "Definition: Thermoactinomycetes described as a genus of high GC content ACTINOBACTERIA in the family Thermomonosporaceae. Species of this genus, Thermomonospora fusca and Thermomonospora curvata, are known for their roles in the industrial production of enzymes including CELLULASE.", + "output": "Thermomonospora species (Thermomonospora Related Organisms)" + }, + { + "input": "Definition: something described as a deviation from the normal straight form of the distal phalanx of the 2nd toe.", + "output": "Curved outermost bone of the 2nd toe (Abnormality of the distal phalanx of the 2nd toe)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as very low-density lipoprotein receptor (873 aa, ~96 kDa) is encoded by the human VLDLR gene. This protein plays a role in the modulation of both reeling signaling and lipoprotein endocytosis.", + "output": "VLDLR protein, human (receptor)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the World Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "CDISC Questionnaire WHODAS 2.0 36-item Version Interviewer-administered Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Antisense Oligonucleotides described as a synthetic antisense oligonucleotide against Bcl-2 messenger RNA with potential antitumor activity. Oligonucleotide SPC2996 binds to and inactivates Bcl-2 mRNA, thereby inhibiting the expression of Bcl-2 protein, promoting tumor cell apoptosis, and potentially enhancing the efficacy of standard cytotoxic chemotherapy. Linked to tumor drug resistance, the antiapoptotic protein Bcl-2 is upregulated in several types of cancers.", + "output": "SPC2996 oligonucleotide (Pharmacologic Substance)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a surgical procedure that uses a laparoscope to guide the removal of the uterus and/or Fallopian tubes and ovaries through the vagina.", + "output": "Laparoscopically Assisted Vaginal Hysterectomy (Vaginal hysterectomy)" + }, + { + "input": "Definition: Heparin group antithrombotic drugs described as a low molecular weight heparin (LMWH) composed of a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Nadroparin binds to antithrombin III (ATIII) and inhibits the activity of activated factor X (factor Xa), thereby inhibiting the final common pathway of the coagulation cascade and preventing the formation of a cross-linked fibrin clot.", + "output": "nadroparin calcium (Heparin group antithrombotic drugs)" + }, + { + "input": "Definition: Drug Administration Routes described as applying a substance topically to a client/patient's skin using an ultrasound device to transfer ions into his or her tissue. Service is billed per treatment.", + "output": "therapy phonophoresis (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Pectoral girdle structure described as one of a pair of bones linking the scapula and the sternum. The clavicle is part of the pectoral girdle.", + "output": "bone of clavicle (Skeletal bone)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a molecular abnormality indicating rearrangement of the ROS1 gene.", + "output": "ROS1 Gene Rearrangement (Receptor Tyrosine Kinase Gene Rearrangement)" + }, + { + "input": "Definition: Elevated tissue non-specific alkaline phosphatase described as an abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.", + "output": "Elevated ALP of hepatic origin (Elevated tissue non-specific alkaline phosphatase)" + }, + { + "input": "Definition: CONGENITAL ANOMALIES OF THE BILIARY TRACT, GALLBLADDER AND LIVER described as the presence of a hypoplastic gallbladder.", + "output": "Congenital small gallbladder (Gallbladder, Agenesis Of)" + }, + { + "input": "Definition: ADCS-ADL Severe Dementia Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia (ADCS-ADL Severe Dementia) Regarding bathing, in the past 4 weeks, which best describes subject's usual performance?", + "output": "ADCS-ADL Severe Dementia - Description of Usual Performance of Bathing (ADCS-ADL Severe Dementia Questionnaire Question)" + }, + { + "input": "Definition: Animal bacterin described as suspensions of bacteria, attenuated or killed bacteria, or their antigenic derivatives administered to induce an immune response for the prevention or treatment of bacterial disease.", + "output": "VACCINES BACT (Pharmacologic Substance)" + }, + { + "input": "Definition: Plethysmographs, Lower Limb described as plethysmographs designed for non-invasive measuring and recording of data and graphics (i.e., a plethysmogram) of the volume and variations in the volume of the lower limbs due to the presence and flow of blood in the peripheral vascular system of the legs. This is based on the measurement of the changes of the values of the impedance (i.e., impedance plethysmography also known as impedance phlebography). These devices typically consist of a unit that includes an impedance meter, controls, and a recorder of the changes of electrical impedance. Two or four electrodes are typically attached to the main unit with electrodes at the distal tips that are placed on the calf. Pressure cuffs placed around the thighs are inflated at a pressure enough to cut off venous flow but not arterial flow. The venous blood pressure rises until it equals the pressure under the cuff; when the cuff is released there is a rapid venous runoff and a prompt return to the resting blood volume. The impedance changes follow a characteristic pattern when a venous obstruction is present that is displayed and/or printed as a graphic. Lower-limb impedance plethysmographs are used to assess peripheral circulation and to assist in diagnosing diseases/disorders related to venous blood flow (e.g., peripheral vascular disease, thrombosis) in the extremities, including deep venous thrombosis as a cause of pulmonary thrombosis.", + "output": "Plethysmographs, Impedance, Lower Limb (Medical Device)" + }, + { + "input": "Definition: Finding described as a finding about one or more characteristics of exocrine or endocrine pancreatic cancer, following the rules of the TNM AJCC v7 classification system. Pancreatic neuroendocrine tumors (including carcinoid tumors) are now staged by a single pancreatic staging system.", + "output": "Exocrine and Endocrine Pancreatic Cancer TNM Finding v7 (Digestive System Cancer TNM Finding v7)" + }, + { + "input": "Definition: Non-human disorder described as any of a group of infections of fowl caused by protozoa of the genera PLASMODIUM, Leucocytozoon, and Haemoproteus. The life cycles of these parasites and the disease produced bears strong resemblance to those observed in human malaria.", + "output": "Malaria, Avian (Parasitic Diseases)" + }, + { + "input": "Definition: something described as occurrence or induction of release of more ova than are normally released at the same time in a given species. The term applies to both animals and humans.", + "output": "Superovulations (Finding of ovulation)" + }, + { + "input": "Definition: Gene or Genome described as human HES3 wild-type allele is located in the vicinity of 1p36.31 and is approximately 1 kb in length. This allele, which encodes transcription factor HES-3 protein, is involved in the negative regulation of transcription.", + "output": "bHLHb43 (Gene or Genome)" + }, + { + "input": "Definition: something described as nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.", + "output": "Quantum dots (Manufactured Object)" + }, + { + "input": "Definition: Lesion described as skin lesion, greater than 2 cm, flat, colored; differs from a macule only in size", + "output": "Skin Plaque (Lesion of skin and/or skin-associated mucous membrane)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with any enzyme.", + "output": "enzyme binding (Molecular Function)" + }, + { + "input": "Definition: Portal Venous System described as short thick vein formed by union of the superior mesenteric vein and the splenic vein; enters the liver at the hepatic portal.", + "output": "VEIN, PORTAL (OTHER ABDOMINAL VEINS)" + }, + { + "input": "Definition: Vaccine Adjuvant described as a lipophilic disaccharide derivative of muramyl dipeptide (MDP) with strong immunostimulating activity and used as a vaccine adjuvant. MDP, a component of bacterial cell wall, is the minimum chemical structure required for macrophage activation. Due to MDP's toxicity and short duration of action, theramide was developed with improved stability, and can be administered without a liposome carrier. Theramide stimulates macrophage activity, which in turn potentiates other immune responses, including the release of proinflammatory interleukins and tumor necrosis factor alpha (TNF alpha). The release of these cytokines further augments the activation of cellular and humoral immune system.", + "output": "N-acetylglucsamnmyl-N-acetylmuramyl-L-Al-D-isoglu-L-Ala-dipalmitoxy propylamide (Immunologic Adjuvants)" + }, + { + "input": "Definition: Face described as the sulcus (furrow) below the lower eyelid", + "output": "Sulcus infrapalpebralis (Body Location or Region)" + }, + { + "input": "Definition: Evaluation described as studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.", + "output": "evaluation programs (Health Care Evaluation Mechanisms)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation described as molecular assay reagents intended for use in identifying exchanges (i.e., translocations) between chromosome 5 band q33 and chromosome 12 band p13, usually involving genes PDGFRB and ETV6, respectively. This translocation is characteristic of myeloproliferative/myelodysplastic syndromes with eosinophilia. Its detection may be used as a tumor marker.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(5;12)(q33;p13) (Medical Device)" + }, + { + "input": "Definition: something described as lower limb prostheses designed for partial functional (primarily flexion) replacement of the distal portion of a missing limb amputated at the ankle articulation, in which the tibial component of the articulation is preserved. These prostheses typically consist of external or partially implantable devices with a mechanism that provides flexion (i.e., acting as a hinge) and some degree of internal and external rotation and locking positions at the distal end of the foot component of the prosthesis; they are usually attached at the proximal end with a socket that allows direct load transfer (i.e., end-bearing) making intimate socket fit less crucial than in through-bone amputations. Disarticulation ankle prostheses are available in a great variety of configurations and sizes; they may be passive, mechanical, or patient-actuated. The prostheses are used mainly in patients who have congenital abnormalities or who suffered amputations due to illness (e.g., diabetes) or traumatic accidents.", + "output": "Prostheses, Lower Limb, Ankle Disarticulation (Lower Limb Prostheses)" + }, + { + "input": "Definition: polyol metabolic process described as the chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms.", + "output": "polyol formation (polyol metabolic process)" + }, + { + "input": "Definition: Genetic Function described as any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.", + "output": "down regulation of t-circle formation (Genetic Function)" + }, + { + "input": "Definition: Descriptors described as the space or interval separating two things.", + "output": "Intermediate (Spatial Qualifier)" + }, + { + "input": "Definition: something described as the general personal and health characteristics that have a bearing on the course of a disease and its eventual outcome.", + "output": "Prognostic Factor (Clinical Attribute)" + }, + { + "input": "Definition: Follicle center lymphoma, follicular grade I, II, III stage IV described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.", + "output": "metastatic follicular large cell lymphoma (Follicle center lymphoma, follicular grade I, II, III stage IV)" + }, + { + "input": "Definition: something described as the part of the lateral spinothalamic tract in the medulla ( NeuroNames ).", + "output": "lateral spinothalamic tract of the medulla (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Drug allergens described as a drug that is being studied in the treatment of cancer", + "output": "eflornithine (Allergen class)" + }, + { + "input": "Definition: Disease or Syndrome described as acute hepatic injury resulting from inflammation typically accompanied by increased serum alanine transaminase activity. Etiologies include viral hepatitis, drugs, toxins, and autoimmune disorders. []", + "output": "Acute hepatitis, NOS (Liver)" + }, + { + "input": "Definition: Western Europe described as a country in southwestern Europe, bordering the Bay of Biscay, Mediterranean Sea, and North Atlantic Ocean, southwest of France.", + "output": "spain (Affiliate Realms)" + }, + { + "input": "Definition: something described as a colorless, crystalline compound that emits toxic fumes of nitrogen oxides when heated to decomposition. Hydrazobenzene has been used primarily in the dye manufacturing industry as the precursor of the dye intermediate benzidine and is also used as an intermediate in the manufacture of pharmaceuticals. Exposure to this substance irritates the skin, nose, throat and lungs and can eventually lead to liver, kidney and brain damage. Hydrazobenzene is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals.", + "output": "1,2-diphenylhydrazine (Epichlorohydrin)" + }, + { + "input": "Definition: Metals described as an element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.", + "output": "cerium (Metals)" + }, + { + "input": "Definition: Professional or Occupational Group described as an individual who has knowledge of specific techniques, instruments, and equipment required in performing specific cardiovascular/peripheral vascular diagnostic procedures.", + "output": "Cardiology Technician (Professional or Occupational Group)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as innermost layer of the leptomeninges, which adheres to the brain and spinal cord and conforms to all the irregularities on their surfaces.", + "output": "pia (Leptomeninges)" + }, + { + "input": "Definition: Indicator described as an indication as to whether the Individual Case Safety Report (ICSR) contains at least one suspected medical product that is a combination product.", + "output": "Combination Product Report Indicator (Indicator)" + }, + { + "input": "Definition: Q-LES-Q-SF Questionnaire Question described as quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) Taking everything into consideration, during the past week how satisfied have you been with your: economic status?", + "output": "QLES210 (Q-LES-Q-SF Questionnaire Question)" + }, + { + "input": "Definition: something described as relating to epithelium which is Membranous tissue composed of one or more layers of cells", + "output": "Epithelial (Qualitative Concept)" + }, + { + "input": "Definition: acute lymphocytic leukemia in relapse described as a myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis. Microscopically, there is interstitial infiltration of the testis by leukemic cells. Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys. Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia. --03", + "output": "leukemia lymphocytic acute (all) in relapse testicular leukemia (Malignant neoplasm of testis)" + }, + { + "input": "Definition: something described as a cytochemical staining technique used to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias blasts stain when the butyrate substrate is used. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques.", + "output": "Butyrate esterase stain (Hematology staining procedure)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a XCR1 chemokine receptor.", + "output": "XCR1 chemokine receptor binding (chemokine receptor binding)" + }, + { + "input": "Definition: adenosine monophosphate described as adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.", + "output": "Adenosine 5'-Pyrophosphate (Ribonucleotides)" + }, + { + "input": "Definition: Unit of Arbitrary Substance Concentration described as a unit of concentration (biologic activity) equal to one micro-international unit of substance per liter of solution.", + "output": "u[IU]/L (Quantitative Concept)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the epidermal growth factor receptor (EGFR) gene, located at chromosome 7p12.3-p12.1. Mutations at this locus have been identified in most patients with non-small-cell lung cancer and adenocarcinoma of the lung and may be associated with other carcinomas (e.g., glioblastoma).", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, EGFR (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: therapeutic autologous lymphocytes described as a preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD22 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD22-4SCAR-expressing T-cells 4SCAR22 are directed to and induce selective toxicity in CD22-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity.", + "output": "CD22-4SCAR-expressing T Lymphocytes (Chimeric Antigen Receptor T-cells)" + }, + { + "input": "Definition: Finding described as an intended site for a dose form that is for administration to the respiratory tract.", + "output": "Pulmonary (Dose form intended site)" + }, + { + "input": "Definition: Cell described as human COLORECTAL CARCINOMA cell line.", + "output": "HCT-116 Cell (Cell)" + }, + { + "input": "Definition: ENDOCRINE FEATURES described as a rare hormonal disease that occurs when the body produces too much of the hormone cortisol", + "output": "Cushing Syndrome (Endocrine and metabolic secondary hypertension)" + }, + { + "input": "Definition: something described as surgery to treat a glioma, glioblastoma or astrocytoma.", + "output": "Glioma, Glioblastoma & Astrocytoma Surgery (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as injections into the cerebral ventricles.", + "output": "Intraventricular Injections (Injection Route of Drug Administration)" + }, + { + "input": "Definition: something described as an electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, and upright T wave, which is suggestive of myocardial infarction of the posterior wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present.", + "output": "Posterior Myocardial Infarction by EKG Finding (Electrocardiogram: myocardial infarction)" + }, + { + "input": "Definition: Cell Count described as the determination of the amount of basophilic normoblasts present in a sample from an experimental organism.", + "output": "NORMBASO (Cell Count)" + }, + { + "input": "Definition: metanephric glomerular epithelial cell fate commitment described as the process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.", + "output": "metanephric podocyte cell fate commitment (glomerular visceral epithelial cell fate commitment)" + }, + { + "input": "Definition: Pharmacologic Substance described as pancreatic enzymes are comprised primarily of proteases, lipase and amylase that catalyze the breakdown of fats, carbohydrates and proteins during the digestion of food. However, the pancreas also produces many other digestive enzymes such as ribonuclease, deoxyribonuclease, gelatinase and elastase.", + "output": "Pancreatic enzyme product (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) During the last week, was it easy or hard for you to: Use a fork and spoon?", + "output": "PODCI Adolescent Self-Reported Version - Use a Fork and Spoon (PODCI Adolescent Self-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as a radioisotope with an atomic number of 75 and a half life of 90 hours that emits beta particles and gamma rays and is used in cancer treatment and diagnostic imaging technique.", + "output": "Rhenium-186 (Radioisotopes)" + }, + { + "input": "Definition: Tricuspid valve feature described as the time interval from the closure of the 1st Doppler spectral taken from the tricuspid valve to the opening of the 2nd Doppler spectral of the tricuspid valve.", + "output": "Tricuspid valve closure to opening time (Clinical Attribute)" + }, + { + "input": "Definition: Functional Concept described as a person who has physical possession or legal rights to something.", + "output": "holder - ParticipationType (Persons)" + }, + { + "input": "Definition: something described as olated from mosquitoes in the Semliki Forest, Uganda; pathogenic for laboratory animals and man.", + "output": "SFV - Semliki Forest virus (Non human viruses)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of metalloproteases that are related to the DROSOPHILA protein tolloid, which is a gene product necessary for dorsal-ventral patterning in early Drosophila embryogenesis. Many members of the group may play a significant role in intercellular signaling.", + "output": "Tolloid-Like Metalloproteinases (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell described as in semen analysis, leukocytes and immature germ cells are collectively referred to as round cells.", + "output": "Population of all round cells in portion of fluid (Population of cells in portion of fluid)" + }, + { + "input": "Definition: PTEN gene mutation described as a nucleotide substitution at position 389 of the coding sequence of the PTEN gene where guanine has been mutated to thymine.", + "output": "PTEN c.389G>T (PTEN gene mutation)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT Version 4) I am bothered by skin problems.", + "output": "FACT-BMT Version 4 - I Am Bothered by Skin Problems (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene (~4.4 kb) that results from a chromosomal translocation t(17;19)(q22;p13) which fuses intron 13 of the TCF3 gene with intron 3 of the HLF gene. This rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.", + "output": "TCF3/HLF Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.", + "output": "Polygalactin 910 (Biomedical or Dental Material)" + }, + { + "input": "Definition: Stage IA Lung Non-Small Cell Carcinoma AJCC v7 described as stage IA3 includes: T1c, N0, M0. T1c: Tumor measuring more than 2 cm but 3 cm or less in greatest dimension. N0: No regional lymph node metastases. M0: No distant metastasis.", + "output": "Stage IA3 Lung Cancer (Stage IA Lung Non-Small Cell Carcinoma AJCC v7)" + }, + { + "input": "Definition: something described as a subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.", + "output": "Transforming Growth Factor-beta1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as licensed facilities permitted to prepare animal food with added medications.", + "output": "MEDICATED ANIMAL FEED MANUFACTURE (Manufacture)" + }, + { + "input": "Definition: Immunoproteins described as c-type lectin domain family 7 member A (247 aa, ~28 kDa) is encoded by the human CLEC7A gene. This protein plays a role in the innate immune response against pathogenic bacteria and fungi.", + "output": "Dendritic Cell-Associated C-Type Lectin 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: other analgesics described as a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.", + "output": "Hyaluronic acid product (Organic Chemical)" + }, + { + "input": "Definition: Population Group described as a kind of physical entity which is intended to be the primary unit of operational and/or administrative interest in a study. EXAMPLE(S): 10 Adult males, 20 female 6-month old chickens OTHER NAME(S): NOTE(S): Some studies may specify multiple kinds of subjects, each with their own quantity.", + "output": "Planned Study Subject (Population Group)" + }, + { + "input": "Definition: MISCELLANEOUS SPECIFIC ANTIBODIES described as proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.", + "output": "Opsonin Protein (Functional Immunologic Units)" + }, + { + "input": "Definition: something described as a prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin. This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin. Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland. Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1853\" active clinical trials using this agent.", + "output": "L-377202 (Pharmacologic Substance)" + }, + { + "input": "Definition: Cell Function described as the dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network.", + "output": "contractile vacuole detethering from plasma membrane (Cell Function)" + }, + { + "input": "Definition: Neurosurgical Procedures described as cutting off the afferent nerve supply. Often performed to relieve pain. (Taber's).", + "output": "Deafferentation procedure (Neurosurgical Procedures)" + }, + { + "input": "Definition: something described as a massive dog with a powerful body. Muscular and athletic, it has a broad head and rounded forehead. The coat is short, hard, and thick. It is black with brown markings on the cheeks and muzzle, paws and legs. A red color with brown markings also exists. The average height range is 22-27 inches and the average weight range is 85-130 pounds.", + "output": "Rottweiler (Canis familiaris)" + }, + { + "input": "Definition: something described as adapted or specially designed equipment, products and technologies that assist people to send and receive information, such as specialized vision devices, electro-optical devices, specialized writing devices, drawing or handwriting devices, signalling systems and special computer software and hardware, cochlear implants, hearing aids, FM auditory trainers, voice prostheses, communication boards, glasses and contact lenses.", + "output": "Assistive products and technology for communication (Manufactured Object)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Abdominal Infection, CTCAE (Abdominal Infection, CTCAE)" + }, + { + "input": "Definition: Body Location or Region described as a subdivision of the cerebral cortex of the guenon defined on the basis of cytoarchitecture and myeloarchitecture. It is composed of two divisions, area 19a of Vogts and area 19b of Vogts ( Vogts-1919 ).", + "output": "19 (cortical areas of the Vogts)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the plasmacytoid lymphocytes (lymphocytes with peripherally clumped chromatin and often deep blue cytoplasm, and that appear similar to plasma cells) in a biological specimen.", + "output": "plasmacytoid lymphocytes by count (Atypical lymphocyte observed)" + }, + { + "input": "Definition: Clinical Observation described as the year that something was first noted.", + "output": "First Reported Year (Temporal Concept)" + }, + { + "input": "Definition: Diagnostic Procedure described as the absolute volume of air contained in the thoracic cavity at any given point in time and at any level of alveolar pressure.", + "output": "Thoracic Gas Volume Test (Diagnostic Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a benign neoplasm containing two or more cell types arising from the mesenchymal and epithelial components.", + "output": "EPITHELIAL-STROMAL TUMOR, BENIGN (Neoplastic Process)" + }, + { + "input": "Definition: Idea or Concept described as formal relationships established between otherwise independent organizations. These include affiliation agreements, interlocking boards, common controls, hospital medical school affiliations, etc.", + "output": "AFFILIATION ORGAN (Organization and Administration)" + }, + { + "input": "Definition: something described as segment of forearm between elbow and wrist.", + "output": "Forearm proper (Region of forearm)" + }, + { + "input": "Definition: beta-Chemokines described as chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.", + "output": "Monocyte Chemotactic Proteins (beta-Chemokines)" + }, + { + "input": "Definition: something described as the process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.", + "output": "Leydig cell differentiation (Cell Function)" + }, + { + "input": "Definition: something described as CD2-associated protein (639 aa, ~71 kDa) is encoded by the human CD2AP gene. This protein plays a role in both cell division and protein-protein binding.", + "output": "CD2-Associated Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.", + "output": "Tolerance, Central (Self Tolerance)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as subdivision of skull which surrounds the orbit of eye.", + "output": "Wall of orbit (Ocular orbit)" + }, + { + "input": "Definition: Neoplastic Process described as reemergence of verrucous carcinoma of the oral cavity after a period of remission.", + "output": "Recurrent Mouth Verrucous Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Gastrointestinal Fistula, CTCAE 5.0 described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Gastrointestinal fistula (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any therapy that consists of the administration of a variable number of chemotherapeutic agents intrathecally.", + "output": "Variable Intrathecal Chemotherapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a question about how often an individual worries or worried.", + "output": "Worry Frequency (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as a derivative of bromoacrylic acid with cytostatic and antineoplastic activity. Bromebric acid appears to inhibit purine synthesis, oxidative phosphorylation and DNA synthesis. This agent inhibits tumor cell growth and causes cell cycle arrest. This agent may also have some use in the phrophylaxis of migraine.", + "output": "Bromebric Acid (Antimetabolites)" + }, + { + "input": "Definition: something described as a form of limb-girdle muscular dystrophy most often with characteristics of an adult onset (but ranging from 11 to 51 years) of mainly proximal lower limb weakness, with difficulties standing on tiptoes being one of the initial signs. Proximal upper limb and distal lower limb weakness is also common as well as atrophy of the quadriceps (most commonly), biceps brachii, and lower leg muscles. However, calf hypertrophy has also been reported in some cases. LGMD2L progresses slowly, with most patients remaining ambulatory until late adulthood.", + "output": "Autosomal recessive limb girdle muscular dystrophy type 2L (Disease or Syndrome)" + }, + { + "input": "Definition: Data Compression described as a data compression algorithm that reduces the amount of information in the data, rather than just the number of bits used to represent that information.", + "output": "Lossy Compression (Data Compression)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 - I have a good appetite.", + "output": "FAC03022 (Intellectual Product)" + }, + { + "input": "Definition: something described as an increase in the level of ribose in the cerebrospinal fluid.", + "output": "Increased level of ribose in CSF (Finding)" + }, + { + "input": "Definition: Injury by mechanism described as injury to a joint due to flexion of a joint beyond its normal range of movement.", + "output": "Hyperflexion injury (Injury or Poisoning)" + }, + { + "input": "Definition: something described as a class of water-soluble polyelectrolytes with pi-delocalized structure and functional ionic properties used for fluorescent staining of cells and as semi-conducting materials in electronic devices.", + "output": "Conjugated Polyelectrolyte (Chemical Viewed Structurally)" + }, + { + "input": "Definition: something described as a response indicating that an individual wishes to get out more, but is not up to it.", + "output": "Many Times Wish to Go Out More But Not Up to It (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Primary Peritoneal Cancer by AJCC v8 Stage described as stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine.", + "output": "Stage IV Primary Peritoneal Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Organic Chemical described as an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74043\" active clinical trials using this agent.", + "output": "Dual IGF-1R/InsR Inhibitor BMS-754807 (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Child Report (PedsQL Neuromuscular Module Version 3.0 Young Child Report) Think about how you have been doing for the last few weeks. Please listen carefully to each sentence and tell me how much of a problem this is for you: It is hard to use my hands.", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Child Report - Hard to Use Hands (Intellectual Product)" + }, + { + "input": "Definition: Morphological central nervous system abnormality described as an abnormality of the glia cell.", + "output": "Abnormality of the glial cells (Morphological central nervous system abnormality)" + }, + { + "input": "Definition: regulation of cytokine biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14.", + "output": "regulation of interleukin-14 biosynthesis (Cell Function)" + }, + { + "input": "Definition: 11-deoxy-17-ketosteroid described as a 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation.", + "output": "3 alpha Hydroxy 5 beta Androstan 17 One (11-deoxy-17-ketosteroid)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a question about whether an individual has or had trouble doing all of their regular leisure activities with others.", + "output": "Trouble Doing Regular Leisure Activities with Others (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether anyone has expressed concern about an individual's drinking.", + "output": "Has anyone expressed concern about your drinking (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Nucleic acid sequencing described as the determination of the sequence of purines and pyrimidines in deoxyribonucleic acid (DNA).", + "output": "DNA SEQ DETERMINATIONS (Molecular Biology Research Technique)" + }, + { + "input": "Definition: Nitrogen and nitrogen compound described as an alpha- and beta-adrenergic receptor agonist with sympathomimetic activity. Phenylpropanolamine (PPA) binds to and activates alpha- and beta-adrenergic receptors in the mucosa of the respiratory tract resulting in vasoconstriction and reduction in swelling of nasal mucous membranes and reduction in tissue hyperemia, edema, and nasal congestion. This agent also stimulates the release of norepinephrine from its storage sites resulting in the effects already described. Finally, PPA indirectly stimulates beta-receptors producing tachycardia and a positive inotropic effect.", + "output": "norephedrine (Decongestants)" + }, + { + "input": "Definition: Inorganic Chemical described as golden sulphuret of antimony.", + "output": "antimonium sulphuratum/golde (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as a sequence of characters used as a linkage between related exposure records.", + "output": "EXLNKID (Intellectual Product)" + }, + { + "input": "Definition: Special Histology Staining Method described as a microscopy staining method that utilizes Iodine, an element belonging to the halogen group, which specifically stains polysaccharides such as cellulose, chitin, glycogen, and starch a blue color.", + "output": "IODINE STAIN (Special Histology Staining Method)" + }, + { + "input": "Definition: Males described as breast which has as its parts simple lactiferous duct.", + "output": "Male mammary gland (Breast)" + }, + { + "input": "Definition: Czech translation of the Medical Subject Headings described as an organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).", + "output": "Tumor (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Hungarian Edition)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual has or had severe shortness of breath.", + "output": "Severely Short of Breath (Intellectual Product)" + }, + { + "input": "Definition: something described as a nasopharyngeal airway is a device used to aid breathing by means of a tube inserted into a patient's pharynx through the nose to provide a patent airway.", + "output": "airways nasal (Artificial Airways)" + }, + { + "input": "Definition: carbohydrate derivative transport described as the process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol.", + "output": "glycerol-3-phosphate transmembrane transport (Cell Function)" + }, + { + "input": "Definition: Other antiseptics and disinfectants in ATC described as an isomer of propyl alcohol with antibacterial properties. Although the exact mechanism of isopropanol's disinfecting action is not known, it might kill cells by denaturing cell proteins and DNA, interfering with cellular metabolism, and dissolving cell lipo-protein membranes. Isopropanol is used in soaps and lotions as an antiseptic.", + "output": "Isopropyl alcohol (Other antiseptics and disinfectants in ATC)" + }, + { + "input": "Definition: Immunology described as an abnormal decreased number of leukocytes in the blood.", + "output": "Disorder characterized by neutropenia (Disease or Syndrome)" + }, + { + "input": "Definition: Office of Communications described as the Office of Cancer Communications supports a nationwide network of offices known as the Cancer Information Service (CIS). The CIS serves as the NCI's primary mechanism to disseminate accurate up-to-date information to the American public at the communit", + "output": "OCICE (Office of Communications)" + }, + { + "input": "Definition: examination of gait and stance described as a type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall.", + "output": "Ataxic gait (Peripheral Nervous System)" + }, + { + "input": "Definition: cancer-related problem/condition described as an individual who has survived a cancer, and is in a disease free, chronic, or relatively stable stage. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C18673\" active clinical trials using this agent.", + "output": "cancer survivor (cancer-related problem/condition)" + }, + { + "input": "Definition: something described as a 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.", + "output": "Trinitrotoluene, device (Munition)" + }, + { + "input": "Definition: catalytic activity, acting on a protein described as catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)].", + "output": "adenylyl(glutamine synthetase) hydrolase activity (phosphoric diester hydrolase activity)" + }, + { + "input": "Definition: hematopoietic stem cell migration described as the orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.", + "output": "hematopoietic stem cell migration to bone marrow (Cell Function)" + }, + { + "input": "Definition: General clinical state described as any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.", + "output": "Adverse Effect (Pathologic Function)" + }, + { + "input": "Definition: something described as underdevelopment of the trapezium.", + "output": "Small trapezium (Abnormality of the trapezium)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Not playing because he or she was depressed.", + "output": "TSCYC188 (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIA includes: T2a, N0, M0. T2a: Tumor invading paravaginal tissues but not to pelvic wall, measuring 2.0 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IIA Vaginal Cancer AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Fetal Diseases described as a cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. Typically, this presents without facies or other growth abnormalities.", + "output": "ARND (Disease or Syndrome)" + }, + { + "input": "Definition: Medical Device described as guide wires designed to provide percutaneous access to, and facilitate passage/placement of catheters and other diagnostic/interventional devices within coronary vessels and cardiac structures. They are typically utilized to access target vessels, cross lesions and deliver interventional therapy. They are available in a variety of configurations that include different sizes (lengths and diameters), core materials, tip designs, covers and coatings (e.g., polymer or plastic covers, hydrophobic or hydrophilic coatings), and stiffness.", + "output": "Guide Wires, Cardiovascular, Coronary (Medical Device)" + }, + { + "input": "Definition: maintenance of protein location in cell described as the retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.", + "output": "protein retention in Golgi apparatus (maintenance of protein location in cell)" + }, + { + "input": "Definition: Cutaneous Melanoma pN3 TNM Finding v8 described as cutaneous melanoma with four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.", + "output": "Melanoma of the Skin pN3a TNM Finding v8 (Cutaneous Melanoma pN3 TNM Finding v8)" + }, + { + "input": "Definition: something described as an anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.", + "output": "Abnormal erythroid lineage cell morphology (Abnormal myeloid cell morphology)" + }, + { + "input": "Definition: Signaling Protein described as protein MRVI1 (885 aa, ~96 kDa) is encoded by the human MRVI1 gene. This protein is involved in the regulation of inositol trisphosphate-dependent calcium mobilization.", + "output": "Protein MRVI1 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a route that begins within a ureter.", + "output": "Ureteral route (Intraabdominal Route of Drug Administration)" + }, + { + "input": "Definition: Pathologic Function described as inability to clear secretions or obstructions from the respiratory tract to maintain a clear airway.", + "output": "Ineffective airway clearance (Physical injury)" + }, + { + "input": "Definition: Body Composition described as using a caliper to measure the thickness of a client's skin at 9 specific sites on his or her body to determine body composition. Service is billed in 15-minute increments.", + "output": "Caliper testing 9 sites each 15 minutes (Health Care Activity)" + }, + { + "input": "Definition: Knowledge acquisition described as introductory courses leading to an advance study in medicine.", + "output": "Propedeutic, Medical (Educational Activity)" + }, + { + "input": "Definition: Type Code described as a coded value specifying the kind of biologic entity identifier. EXAMPLE(S): hospital record number, medical record number", + "output": "Biologic Entity Identifier Type Code (Intellectual Product)" + }, + { + "input": "Definition: Plant Viruses described as a family of icosahedral, non-enveloped, RNA plant viruses comprised of three genera: TYMOVIRUS, Marafivirus and Maculavirus.", + "output": "Tymoviridae (RNA Viruses)" + }, + { + "input": "Definition: NUCLEUS AND ASSOCIATED STRUCTURES described as the designation for each member of the fifth largest human autosomal chromosome pair. Chromosome 5 spans about 181 million base pairs and represents almost 6% of the total DNA in normal diploid cells.", + "output": "CHROMOSOME 05 (Cell Component)" + }, + { + "input": "Definition: something described as the study and treatment of cancers with chemicals, biological products or immunotherapy.", + "output": "medical oncology (oncology field)" + }, + { + "input": "Definition: Medical Devices described as the smallest concentration of an analyte that can be determined with a stated precision or confidence.", + "output": "LOD (Quantitative Concept)" + }, + { + "input": "Definition: Intervention regimes described as prevention of wound complications and promotion of wound healing", + "output": "Wound care (Physiologic Responses)" + }, + { + "input": "Definition: Spatial Concept described as line through and in the direction of an object's characteristic feature that is longer than any other feature.", + "output": "Long Axis (Ultrasound scan - obstetric)" + }, + { + "input": "Definition: Leads described as an electrode cable is a device composed of strands of insulated electrical conductors laid together around a central core and intended for medical purposes to connect an electrode from a patient to a diagnostic machine.", + "output": "EGLEAD (Medical Device)" + }, + { + "input": "Definition: Medical Device described as an ophthalmic sponge is a device that is an absorbant sponge, pad, or spear made of folded gauze, cotton, cellulose, or other material intended to absorb fluids from the operative field in ophthalmic surgery.", + "output": "SPONGE, OPHTHALMIC (Sponges)" + }, + { + "input": "Definition: regulation of DNA-templated transcription, initiation described as any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.", + "output": "negative regulation of DNA-templated transcription, initiation (Genetic Function)" + }, + { + "input": "Definition: Lung mass described as a granuloma that is located in lung tissue.", + "output": "lung; granuloma (Lower respiratory tract inflammatory and immunologic conditions)" + }, + { + "input": "Definition: Multiple malformation syndrome with facial defects as major feature described as german syndrome is an autosomal recessive arthrogryposis syndrome, described in 5 cases. Three of the four known families with affected children were Ashkenazi Jews. German syndrome is characterized by arthrogryposis, hypotonia-hypokinesia sequence, and lymphedema. Patients present distinct craniofacial appearance (tall forehead and ''carp'' shaped mouth, cleft palate), contractures, and severe hypotonia manifesting as motor delay and swallowing difficulties. The disease has a severe morbidity and mortality rate and survivors present a small stature, hypotonia, frequent upper respiratory infections and psychomotor delay. There have been no further descriptions in the literature since 1987.", + "output": "GERMAN SYNDROME (Milroy Disease)" + }, + { + "input": "Definition: G Protein-Coupled Receptor Genes described as this gene plays a role in G protein-coupled receptor signal transduction, and may play a role in the regulation of cyclic AMP levels.", + "output": "cholinergic receptor muscarinic 5 (Gene or Genome)" + }, + { + "input": "Definition: Recurrent Ovarian Adenocarcinoma described as the reemergence of ovarian cystadenocarcinoma after a period of remission.", + "output": "Recurrent Ovarian Cystadenocarcinoma (Recurrent Ovarian Adenocarcinoma)" + }, + { + "input": "Definition: Locking Mechanism Device described as the type of locking device used to securely fasten the electrical leads to the device.", + "output": "Electrical Lead Locking Type (Functional Concept)" + }, + { + "input": "Definition: dopamine neurotransmitter receptor activity described as combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.", + "output": "dopamine neurotransmitter receptor activity, coupled via Gi/Go (Molecular Function)" + }, + { + "input": "Definition: Cytokine Measurement described as the determination of the amount of chemokine present in a sample.", + "output": "Chemokine Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Cardiopulmonary described as transmission of an infectious disease by direct contact with an affected individual, the individual's discharges or by indirect means such as by a vector.", + "output": "Transmitted (Pathologic Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as any elsewhere undefined homeopathic remedy letter O, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "Undefined homeopathic remedy letter O narrative required (Homeopathic remedies letter O)" + }, + { + "input": "Definition: Projectors, Photographic/Microscope Slide described as photo slide projectors designed for projection on a screen one slide from a set of positive images mounted on transparent film (i.e., eye charts) that are intended for visual function assessment. These projectors usually consist of electric powered equipment that includes a power supply, lights (e.g., halogen), lenses, electronic circuitry, controls (e.g., focus, brightness), screens, and sealed slide holders (e.g., discs) and/or carrousels carrying a set of multiple eye charts; the projector may include other attachments that permit the projection of the eye chart's images with the appropriate size, definition, and brightness adequate for visual assessment. Some projectors may include as a component the screen intended for projection of the images. Eye chart projectors are used for screening and evaluation of a patient's visual function in doctors' offices and other areas of healthcare facilities.", + "output": "Chart Projectors, Eye (Medical Device)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of gastrointestinal stromal tumor, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.", + "output": "Gastrointestinal Stromal Tumor Clinical Distant Metastasis TNM Finding v7 (Gastrointestinal Stromal Tumor Clinical TNM Finding v7)" + }, + { + "input": "Definition: something described as an adenocarcinoma that arises from the maxillary sinus.", + "output": "Adenocarcinoma of Maxillary Sinus (Maxillary Sinus Carcinoma)" + }, + { + "input": "Definition: something described as a thick, protein-rich substance secreted by the breasts during the second half of pregnancy and for a few days after birth before the breast milk comes in. It contains antibodies which serve to give the baby protection from disease and also has a laxative effect on the colon which helps to expel the plug of meconium and facilitate the establishment of normal bowel movements.", + "output": "Human Colostrum (Organic Chemical)" + }, + { + "input": "Definition: Bacterium described as a species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is endochitinase positive, mesophilic, hydrolyzes starch, reduces nitrate and is indole positive. C. paraputrificum is pathogenic in humans but not in rabbits or guinea pigs.", + "output": "Bacillus diaphthirus (Clostridium species g-p)" + }, + { + "input": "Definition: Finding described as event in which the device software results in errors of medication preparation or administration.", + "output": "Medication Error due to Application Program Problem (Incorrect Programming Calculation Associated with Medical Device)" + }, + { + "input": "Definition: Laboratory Procedure described as a diagnostic tool used to view tissues at high magnification, which allows for identification of cellular structures.", + "output": "Diagnostic Microscopy (Laboratory Procedure)" + }, + { + "input": "Definition: SI-derived unit of area described as a unit of area measurement equal to a square measuring one centimeter on each side. One square centimeter is equal to 1E-4 square meter.", + "output": "sq. cm (SI-derived unit of area)" + }, + { + "input": "Definition: Anatomic pathology procedure described as any form of microscopy in which the interactions of electrons with the specimens are used to provide information about the final structure of that specimen.", + "output": "EM (ObservationMethod - CodeSystem)" + }, + { + "input": "Definition: Newborn States described as multiple fetuses birthed live or dead in a single pregnancy regardless of gestational age, and regardless of whether the fetuses were birthed on different dates.", + "output": "BIRTH MULTIPLE (Prenatal AND/OR neonatal state)" + }, + { + "input": "Definition: something described as a histidine test system is a device intended to measure free histidine (an amino acid) in plasma and urine. Histidine measurements are used in the diagnosis and treatment of hereditary histidinemia characterized by excess histidine in the blood and urine often resulting in mental retardation and disordered speech development.", + "output": "MICROBIOLOGICAL, HISTIDINE (Medical Device)" + }, + { + "input": "Definition: DNA strand elongation involved in DNA replication described as any DNA strand elongation that is involved in cell cycle DNA replication.", + "output": "DNA replication elongation involved in cell cycle DNA replication (cell cycle process)" + }, + { + "input": "Definition: Statistics as Topic described as the use of statistical and mathematical methods to analyze biological observations and phenomena.", + "output": "statistics/biometry (Mathematics)" + }, + { + "input": "Definition: something described as a genus of ASTROVIRIDAE infecting avian species and often involving extra-intestinal manifestations. The type species is Turkey astrovirus.", + "output": "Avastrovirus (Virus)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of synapse pruning.", + "output": "regulation of synapse removal (regulation of synapse organization)" + }, + { + "input": "Definition: educational programs described as u.S. Government educational program for disadvantaged elementary school students to supplement Project Head Start and encourage academic and psychosocial growth.", + "output": "Project Follow Through (Educational Activity)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 9p", + "output": "9p13 (Cell Component)" + }, + { + "input": "Definition: Disease or Syndrome described as degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.", + "output": "Disc Degenerations (Spinal Degenerative Disorder)" + }, + { + "input": "Definition: something described as a user environment where a curator may explore curation techniques or illustrate options without making the work products available for general use.", + "output": "Test Context (Conceptual Entity)" + }, + { + "input": "Definition: Finding described as a condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.", + "output": "Thrombocytopenic Disorder (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Intellectual Product described as emotion Recognition Test (ERT) Number of surprise stimuli responded to as fear.", + "output": "EMO113C (Intellectual Product)" + }, + { + "input": "Definition: something described as an Indo-European language of the Indo-Aryan branch that is the native language of the Sinhalese people, who make up the largest ethnic group in Sri Lanka.", + "output": "Sinhala language (Indo-Aryan Language)" + }, + { + "input": "Definition: Diplococci described as any bacteria appearing as paired spheres that contains low levels of peptidoglycan in its cell wall and stains pink with the Gram staining technique.", + "output": "Gram-Negative Diplococcus (Gram-negative coccus)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare non-progressive form of cone photoreceptor dysfunction characterised by reduced visual acuity, normal retinal appearance and absent or reduce cone responses on electroretinography but normal colour vision. The syndrome is very rare with only 14 cases reported in the literature so far. The causative gene has not been identified. The reason for the presence of normal colour vision despite the reduced visual acuity and electrophysiological evidence of severe cone dysfunction is uncertain. It has been proposed that patients may have reduced numbers of normal functioning cones with preservation of the three cone types in normal proportions thereby enabling normal colour vision.", + "output": "Oligocone syndrome (Hereditary retinal dystrophy)" + }, + { + "input": "Definition: Imidazole described as 1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal.", + "output": "Ketoconazole-containing product (Piperazines)" + }, + { + "input": "Definition: Physiologic Function described as any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation.", + "output": "regulation of convergent extension involved in gastrulation (regulation of gastrulation)" + }, + { + "input": "Definition: something described as the patient's musculoskeletal system is composed of the muscular and skeletal systems. The skeletal system includes the bones, muscles, ligaments, tendons, and cartilage that support and connect the bones. The musculoskeletal system provides the framework for the body, enables motion, and provides protection for internal organs. The musculoskeletal system is maintained at or improved from baseline status as monitored throughout the perioperative period.", + "output": "Musculoskeletal status is maintained at or improved from baseline levels (Physiologic Responses)" + }, + { + "input": "Definition: African race described as denotes the inhabitants of Ethiopia, a person from there, or their descendants elsewhere.", + "output": "ETHIOPIAN (Population Group)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of desmoglein 1 antibody in a biological specimen.", + "output": "Desmoglein 1 Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a term that refers to the staging of hilar cholangiocarcinoma according to the American Joint Committee on Cancer, 8th edition. Hilar well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system.", + "output": "Hilar Cholangiocarcinoma by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Medical Device described as units designed to cool and/or rewarm a patient by circulating liquid (e.g., saline) through an intravascular catheter, controlling the patient's core temperature (typically from 32 to 37 degrees Celsius [90 to 99 degrees Fahrenheit]) by heat exchange between the blood and the saline solution through the wall of a balloon, without perfusion of fluids into the body or drawing blood. These devices typically consist of a central console that includes a cooling and heating system; pumps, coils, and/or tubes for circulation and delivery of the liquid to intravascular catheters; and electronic controls with a display to monitor and show patient and equipment data (e.g., patient core and saline temperature, rate of change of core temperature). The units typically provide automatic adjustment of the circulating solution temperature to keep the patient's core temperature at the desired level according to the temperature sensor included in the catheter. Dedicated intravascular catheters with appropriate closed-loop liquid circulation, heat-exchange balloons, and temperature sensors are available for short-term (e.g., a few hours) or longer-term (e.g., a week) patient temperature control; some catheters include several lumens and can be used also as standard central venous catheters. Intravascular patient warming/cooling units are intended to induce hypothermia, maintain normothermia, and rewarm patients; they may be used during surgery and recovery, to preserve cerebral function in patients with brain injuries, after cardiac arrest, in the care of patients with septicemia, and in other intensive care procedures.", + "output": "Warming/Cooling Units, Patient, Circulating-Fluid, Intravascular (Warming/Cooling Units, Patient, Circulating-Liquid)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Child Parent Report - In the past one month, how much of a problem has this been for your child: My child gets sick easily.", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent Report for Child - Get Sick Easily (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as a process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.", + "output": "protein localization to endoplasmic reticulum exit site (protein localization to endoplasmic reticulum)" + }, + { + "input": "Definition: something described as for publications noted as supported by US Government.", + "output": "Research Support, U.S. Government (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: metaphase/anaphase transition of meiotic cell cycle described as the cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II.", + "output": "meiosis II metaphase/anaphase transition (meiosis II cell cycle process)" + }, + { + "input": "Definition: Conceptual Entity described as an Invivo Result captures the results of anti-tumor drug screening.", + "output": "In Vivo Result (Conceptual Entity)" + }, + { + "input": "Definition: Cell Function described as the directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "2-aminoethylphosphonate transport (nitrogen compound transport)" + }, + { + "input": "Definition: Poisoning / injury described as damage to the muscles, bones and their supportive structural attachments.", + "output": "Injury of musculoskeletal system (Traumatic injury by site)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor MPC-3100 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this agent may inhibit the growth and survival of a wide variety of cancer cell types. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability, and degradation of many oncogenic signaling proteins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84836\" active clinical trials using this agent.", + "output": "Hsp90 Inhibitor MPC-3100 (Pharmacologic Substance)" + }, + { + "input": "Definition: Injury by mechanism described as injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.", + "output": "Burn Wound (THERMAL, COLD AND IRRADIATION INJURIES)" + }, + { + "input": "Definition: Deletion of part of chromosome 18 described as a condition in which some or all of the cells of the body contain extra genetic material from chromosome 18. Clinical features of this condition may include the following: spina bifida, hearing loss, cleft lip, cleft palate, undescended testes, rocker bottom feet, micrognathia, low set ears, cardiac anomalies (ventricular septal defect, atrial septal defect, patent ductus arteriosus, tetralogy of Fallot), intellectual disability, holoprosencephaly, pituitary dysplasia, seizures, autoimmune disorders, hip dysplasia, and/or congenital cataracts.", + "output": "del(18q) syndrome (Deletion of part of autosome)" + }, + { + "input": "Definition: Carbonic Anhydrase Inhibitors described as the sodium salt of acetazolamide, a nonbacteriostatic sulfonamide derivative with diuretic and anticonvulsant properties. Acetazolamide is a potent inhibitor of carbonic anhydrase that plays an important role in the control of fluid secretion. Inhibition of this enzyme in the kidney results in a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen, thereby leading to increased bicarbonate and cation excretion, and increased urinary volume. Reduced bicarbonate level in circulation induces reduction of intraocular pressure via osmotic mechanism. The anticonvulsant activity of acetazolamide may contribute to inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61622\" active clinical trials using this agent.", + "output": "N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide Monosodium (Carbonic Anhydrase Inhibitors)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein (1318, ~150 kDa) encoded by the RABEP1/PDGFRB fusion gene. This protein is comprised of 85% of the Rab GTPase-binding effector protein 1, including 3 and a half of the coiled coil domains, fused to the C-terminal transmembrane and cytoplasmic domains of the beta-type platelet-derived growth factor receptor protein, including the protein kinase domain.", + "output": "RABPT5/PDGFRB Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Global Response in Blood described as greater than 50 percent decrease in quantitative measurements of blood tumor burden in baseline from those with high tumor burden at baseline (B2).", + "output": "Partial Response (Global Partial Response)" + }, + { + "input": "Definition: Temporal Concept described as an indication that something has lasted, occurred during, or totalled less than one hour.", + "output": "Less than 1 hour (Temporal Concept)" + }, + { + "input": "Definition: Cardiovascular pressure described as the blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.", + "output": "Venous Pressures, Central (Venous Blood Pressure)" + }, + { + "input": "Definition: something described as moderate pain; limiting instrumental ADL", + "output": "Grade 2 Anal Pain, CTCAE (Finding)" + }, + { + "input": "Definition: something described as human FGF14 wild-type allele is located in the vicinity of 13q33.1 and is approximately 692 kb in length. This allele, which encodes fibroblast growth factor 14 protein, plays a role in nervous system development. Mutation of the gene is associated with spinocerebellar ataxia 27.", + "output": "FGF14 wt Allele (FGF14 gene)" + }, + { + "input": "Definition: Genetic Variation Analysis described as a procedure to test for the presence of mutations in BRCA family genes.", + "output": "BRCA Mutation Analysis (Laboratory Procedure)" + }, + { + "input": "Definition: Biologically Active Substance described as a signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.", + "output": "crk Oncogene Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Hydrolase described as hydrolysis of ATP is coupled with the exchange of hydrogen and potassium ions.", + "output": "Hydrogen Potassium Exchanging ATPase (Hydrolase)" + }, + { + "input": "Definition: something described as a standardized rating scale developed by Giacino et al in 1991, and modified and further characterized by Giacino et al in 2004, which is a classification system used to assist with differential diagnosis, prognostic assessment and treatment planning in patients with disorders of consciousness. This instrument contains 6 subscales addressing auditory, visual, motor, oromotor, communication, and arousal processes.", + "output": "CRSR01 (Intellectual Product)" + }, + { + "input": "Definition: Enzyme Inhibitors described as a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.", + "output": "Pazopanib product (PDGFR Inhibitor)" + }, + { + "input": "Definition: Intellectual Product described as environmental monitoring software designed to operate carbon dioxide monitors, control/monitor a limited number of their functions, and/or process data obtained while monitoring. This software is intended to work only with one or a few models of carbon dioxide monitors, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements performed while monitoring carbon dioxide (e.g., graphical display of concentration in a period of time) in enclosed environments such as anaerobic chambers, glove boxes, and laboratory hoods.", + "output": "Software, Environmental Monitoring, Carbon Dioxide (Software, Environmental Monitoring)" + }, + { + "input": "Definition: Organism Attribute described as associated with men; befitting or characteristic of a man.", + "output": "Masculine (Organism Attribute)" + }, + { + "input": "Definition: Terminology Extensions for Classification described as dietary proteins from POULTRY.", + "output": "Poultry Proteins [EXT] (Immunologic Factor)" + }, + { + "input": "Definition: Occupational Activity described as discarding or destroying garbage, sewage, or other waste matter.", + "output": "refuse disposals (Occupational Activity)" + }, + { + "input": "Definition: something described as one of the smallest of the terriers, this is a sturdy, short legged, little dog with a rough-textured, weatherproof coat that is about 2-3 inches in length. The coat can be solid red, sandy, or dark or silvery blue, with tan markings on the head and legs. The average height range is 9-11 inches and the average weight range is 9-14 pounds.", + "output": "Australian terrier (Dog family)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare thrombophilia disorder characterized by deficiency of protein C. It results in venous thromboembolism.", + "output": "c protein deficiency (ANTICOAGULANT DISORDERS)" + }, + { + "input": "Definition: Planned described as a proposed method to document the recall process for an investigational product.", + "output": "IP Recall Plan (Intellectual Product)" + }, + { + "input": "Definition: Dextrans described as a colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation.", + "output": "dextran iron (Coordination Complexes)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cladribine, cytarabine and filgrastim that may be used in the treatment of childhood acute myeloid leukemia (AML).", + "output": "Cladarabine/Ara-C/G-CSF (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a non-invasive serous neoplasm that arises from the ovary and shows greater cellular proliferation and cytologic atypia as compared to benign ovarian serous tumors, but less as compared to low-grade ovarian serous carcinoma.", + "output": "SBT/APST (Neoplastic Process)" + }, + { + "input": "Definition: negative regulation of cell proliferation involved in kidney development described as any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development.", + "output": "negative regulation of cell proliferation involved in mesonephros development (regulation of cell proliferation involved in mesonephros development)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as neurexin-2 (1712 aa, ~185 kDa) is encoded by the human NRXN2 gene. This protein may play a role in adhesion and signaling in neuronal cells.", + "output": "Neurexin-2 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as cabinets designed for storage of flammable liquids (e.g., alcohol, gasoline, paint). These cabinets typically consist of a welded-steel double wall that acts as a thermal barrier and include vents with flame arrestors to provide external exhaust; some cabinets are made of wood. Flammable-liquid storage cabinets are available in stand-alone, wall-mounted, under-the-counter, and stackable configurations. Some cabinets include automated self-closing degrees capabilities when the temperature reaches a preestablished value (e.g., 70 degrees Celsius/160 degrees Fahrenheit).", + "output": "Cabinets, Storage, Flammable Liquid (Manufactured Object)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how often an individual feels or felt irritable.", + "output": "Feeling irritable (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+.", + "output": "NADPH:CoA-glutathione oxidoreductase activity (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)" + }, + { + "input": "Definition: Blood Cell Count Ratio Measurement described as a relative measurement (ratio or percentage) of the lymphocytes to non-squamous epithelial cells in a biological specimen.", + "output": "Lymphocytes/Non-Squam Epi Cells (Laboratory Procedure)" + }, + { + "input": "Definition: something described as acute lymphoblastic leukemia occurring in children less than one year of age. The majority of the cases are associated with t(11q23)/MLL (Mixed Lineage Leukemia) gene rearrangements.", + "output": "Infant ALL (Childhood Acute Lymphoblastic Leukemia)" + }, + { + "input": "Definition: Disease susceptibility described as factors that affect the probability or predisposition of an individual to the development of cardiovascular disease and its associated complications.", + "output": "cardiovascular disorder risk (Disease susceptibility)" + }, + { + "input": "Definition: something described as branch of biology that deals with living organisms that inhabit the sea.", + "output": "Marine Biology (Occupation or Discipline)" + }, + { + "input": "Definition: File described as a formalized system of organizing and storing digital content in an electronic record system.", + "output": "electronic Trial Master File (Intellectual Product)" + }, + { + "input": "Definition: Neoplasm of cerebrum described as a primary or metastatic neoplasm that affects the hypothalamus.", + "output": "Tumors, Hypothalamus (Neoplastic Process)" + }, + { + "input": "Definition: Protease inhibitor protein described as a vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.", + "output": "Protein C (Indirect acting anticoagulant)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(11;12)(q23;q13) which fuses exon 9 of the MLL gene to most of the SARNP gene. This rearrangement is associated with acute myelomonocytic leukemia.", + "output": "MLL/SARNP Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the ornithine carbamoyltransferase (OTC) gene, located at chromosome Xp21.1, which encodes for the enzyme ornithine transcarbamylase that participates in the urea cycle. Mutations at this locus have been identified in male patients with ornithine transcarbamylase deficiency (OTCD); carrier females may suffer vomiting, lethargy, and seizures.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, OTC (Medical Device)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective score of 10 on a perceived exertion scale that ranges from 6: No exertion at all to 20: Maximal exertion.", + "output": "Between very light and light (Intellectual Product)" + }, + { + "input": "Definition: Hypophysitis described as a rare acquired pituitary hormone deficiency a type of primary hypophysitis with characteristics of inflammation of anterior pituitary. Clinical presentation is variable and includes headaches, visual disturbances, and symptoms of adrenal insufficiency, hyperprolactinemia, hypothyroidism and hypogonadism. It most commonly affects young women during pregnancy or postpartum period.", + "output": "Adenohypophysitis (Hypophysitis)" + }, + { + "input": "Definition: Biologic Function described as any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.", + "output": "establishment and maintenance of substance location (Biologic Function)" + }, + { + "input": "Definition: protein demethylation described as the modification of histones by removal of methyl groups.", + "output": "histone demethylation (Molecular Function)" + }, + { + "input": "Definition: Esophageal Stenosis, CTCAE described as asymptomatic; clinical or diagnostic observations only; intervention not indicated", + "output": "Grade 1 Esophageal stenosis (Esophageal Stenosis, CTCAE)" + }, + { + "input": "Definition: Organic Chemical described as dietary fiber source, extracted from rind of citrus fruits, and used as a gelling agent.", + "output": "citrus pectin (Organic Chemical)" + }, + { + "input": "Definition: 6-sulfoquinovose(1-) metabolic process described as the chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-).", + "output": "6-sulfoquinovose(1-) breakdown (organic acid catabolic process)" + }, + { + "input": "Definition: Manufactured Object described as a device consisting of a narrow loop of material moving over shafts or pulleys.", + "output": "Belt, NOS (Fastening)" + }, + { + "input": "Definition: something described as the fluid (noncellular) portion of the circulating blood, as distinguished from the serum that is the fluid portion of the blood.", + "output": "Plasma Product (Blood product)" + }, + { + "input": "Definition: something described as a neurosurgical chair is an operating room chair used to position and support a patient during neurosurgery.", + "output": "Neurosurgical chair (Medical Device)" + }, + { + "input": "Definition: Neoplasm of upper respiratory tract described as the reemergence of nasopharyngeal cancer after a period of remission. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9240\" active clinical trials using this agent.", + "output": "Relapsed Nasopharyngeal Cancer (stage, nasopharyngeal cancer)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Young Children - Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Not sleeping for two or more days.", + "output": "TSCYC1-Not Sleeping for Two or More Days (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: something described as a plant family of the order Hydrocharitales, subclass ALISMATIDAE, class Liliopsida (monocotyledons).", + "output": "Najadaceae Juss., 1789 (Plant)" + }, + { + "input": "Definition: Cardiac function described as a state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and HYPOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.", + "output": "Cardiac Output, High (Signs and Symptoms)" + }, + { + "input": "Definition: Health behavior described as extent to which the patient follows prescribed treatment such as keeping APPOINTMENTS AND SCHEDULES and MEDICATION ADHERENCE for desired therapeutic outcome. It implies active responsibility shared by patient and health care providers.", + "output": "Therapeutic Adherence and Compliance (Individual Behavior)" + }, + { + "input": "Definition: Structure of subtalar joint region described as the plane synovial joint between the talus and calcaneus bones of the foot.", + "output": "Subtalar joint structure (Intertarsal joint structure)" + }, + { + "input": "Definition: something described as an esophageal carcinoma characterized by the presence of distinguishable squamous and glandular carcinomatous components.", + "output": "Oesophageal adenosquamous carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Functional Concept described as the completed activity within the context of a given study that represents the storage of some material.", + "output": "PerformedMaterialStorage (Material Storage)" + }, + { + "input": "Definition: something described as the uppermost, flat surface of a table.", + "output": "Table Top (Manufactured Object)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid.", + "output": "dihydroxyphenylalanine dioxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Bacterium described as a species of anaerobic, Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria. This species is nonmotile, non-hemolytic and cannot reduce sulfate in the presence of acetate alone. D. piger has mostly been isolated from human clinical specimens and may be associated with inflammatory bowel disease.", + "output": "Desulfomonas pigra Moore et al. 1976 (Bacterium)" + }, + { + "input": "Definition: something described as endocrine gland, usually in close proximity to the thyroid gland, that produces parathyroid hormone.", + "output": "PARATHYROID GLANDS (Homogeneous organ)" + }, + { + "input": "Definition: NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases described as a light-activated enzyme that catalyzes the oxidation of (S)-malate to OXALOACETATE. It is involved in PYRUVATE metabolism and CARBON fixation.", + "output": "malate dehydrogenase (Enzyme)" + }, + { + "input": "Definition: Enzyme described as an enzyme which catalyzes the catabolism of S-ADENOSYLHOMOCYSTEINE to ADENOSINE and HOMOCYSTEINE. It may play a role in regulating the concentration of intracellular adenosylhomocysteine.", + "output": "S adenosylhomocysteine Hydrolase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Occupational Activity described as text editing and storage functions using computer software.", + "output": "Word Processing (Machine Activity)" + }, + { + "input": "Definition: Sedatives described as synthetic narcotic analgesic used where a relatively short duration of analgesia is desired; abuse of this drug may lead to dependence.", + "output": "Meperidine (Narcotic Drugs)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the transmembrane protein 43 (TMEM43) gene, located at chromosome 3p25.1, which encodes the protein transmembrane protein 43. Genetic variants at this locus have been associated with Emery-Dreifuss muscular dystrophy and arrhythmogenic right ventricular cardiomyopathy.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TMEM43 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Lactobacillus paracasei.", + "output": "LACTOBACILLUS PARACASEI (L [Preparations])" + }, + { + "input": "Definition: Aerobic Gram Negative Bacillus described as a genus of gram-negative, chemoorganotrophic bacteria in the family Sphingobacteriaceae. They lack FLAGELLA but some species exhibit sliding motility.", + "output": "246 SPHINGOBACTERIUM (Bacteroidetes)" + }, + { + "input": "Definition: Sphingolipid and sphingolipid derivative described as a class of dietary lipids containing a long-chained sphingosine group (unsaturated amino alcohol with formula C18H37NO2), fatty acids bound to the NH2 group as an amide, and either sugars or phosphoric acid and alcohols bound to the primary hydroxy group .", + "output": "Sphingolipids (Membrane Lipids)" + }, + { + "input": "Definition: something described as an incision that involves deep soft tissues.", + "output": "deep incision (Finding)" + }, + { + "input": "Definition: something described as widespread and intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL", + "output": "Grade 2 Pruritus/itching (Pruritus, CTCAE)" + }, + { + "input": "Definition: Procedure by method described as the stimulation of uterine contractions using pharmacologic methods or artificial rupture of membranes (AROM) to increase their frequency and/or strength following the onset of spontaneous labor or contractions following spontaneous rupture of membranes. Does not apply if induction of labor is performed.", + "output": "augmentation of labor (Medical procedure on genitourinary system, NOS)" + }, + { + "input": "Definition: Language commonly spoken in Europe described as a Western Romance language native to parts of Andorra, France, Italy, and Spain.", + "output": "Catalan language (Language commonly spoken in Europe)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Child Parent Report - In the past 7 days, how much of a problem has this been for your child: My child gets sick easily.", + "output": "PQL17-Get Sick Easily (Intellectual Product)" + }, + { + "input": "Definition: something described as the capability of bearing live young (rather than eggs) in nonmammalian species. Some species of REPTILES and FISHES exhibit this.", + "output": "Viviparity, Nonmammalian (Reproduction)" + }, + { + "input": "Definition: Focal aware emotional seizure described as focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is retained throughout.", + "output": "Focal aware emotional seizure with fear/anxiety/panic (Focal emotional seizure with fear/anxiety/panic)" + }, + { + "input": "Definition: Mammals described as a diverse taxonomic order of placental mammals that includes bears, dogs, cats, and ferrets. Carnivora are primarily meat eaters, however bears are omnivorous and herbivorous pandas may consume fish and insects.", + "output": "carnivore (Duplicate concept)" + }, + { + "input": "Definition: Salivary gland carcinoma described as an adenocarcinoma arising from the salivary gland. It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified.", + "output": "Adenocarcinoma of salivary gland (High Grade Salivary Gland Carcinoma)" + }, + { + "input": "Definition: something described as performance of the Upper Limb Module for DMD Version 1.2 - Tearing paper.", + "output": "PUL01N (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as poison nut.", + "output": "Nux vomica homeopathic preparation (Organic Chemical)" + }, + { + "input": "Definition: Molecular Function described as catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A .", + "output": "tetraketide alpha-pyrone synthase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: something described as the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.", + "output": "sperm mitochondrial sheath (Cell Component)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally available small molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK), with potential antineoplastic activity. Upon administration, MEK inhibitor SHR 7390 selectively binds to and inhibits the activity of MEK. This prevents the activation of MEK-dependent effector proteins, which results in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual-specificity threonine/tyrosine kinase family that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types.", + "output": "MEK Inhibitor SHR 7390 (Pharmacologic Substance)" + }, + { + "input": "Definition: plasma membrane protein complex described as a protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.", + "output": "flotillin complex (Cell Component)" + }, + { + "input": "Definition: something described as a human plasma-derived, polyclonal, intravenous immunoglobulin G (IgG) formulation containing high levels of antibodies against hepatitis C virus (HCV), a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, with potential immunomodulating and antiviral activities. The hepatitis C IgG is isolated from donors expressing high amounts of HCV antibodies. Upon intravenous administration, the anti-HCV antibodies bind to the virus and provide passive immunization against HCV. This may prevent both infection by HCV in immunocompromised patients and hepatitis C-related liver disease. The polyclonal anti-HCV antibodies are able to target various viral epitopes.", + "output": "HCIG (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Pharmaceutical Preparations described as an anticancer drug that belongs to the family of drugs called alkylating agents.", + "output": "SZN (Anti-Bacterial Agents)" + }, + { + "input": "Definition: Vaccine Adjuvant described as a guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process.", + "output": "7-allyl-8-oxoguanosine (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: something described as combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity.", + "output": "C2H4 receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as middling or intermediate in degree, quality or extent.", + "output": "Moderately (General Qualifier)" + }, + { + "input": "Definition: something described as a protein encoded by the EGFR gene.", + "output": "EGFR Gene Product (ErbB Receptors)" + }, + { + "input": "Definition: catalytic activity, acting on a protein described as catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2.", + "output": "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Gene Mutation described as this gene plays a role in the generation of superoxide in phagocytes.", + "output": "CYBB (Oxidoreductase Gene)" + }, + { + "input": "Definition: Burkholderia described as a group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.", + "output": "Burkholderia cepacia complex (Bacterium)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate.", + "output": "dUMP catabolic process (pyrimidine deoxyribonucleotide catabolic process)" + }, + { + "input": "Definition: Maleae described as a plant genus of the family ROSACEAE.", + "output": "Ashs, Mountain (Rosaceae)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) AIDS or DEVICES that you usually use for any of these activities - Wheelchair.", + "output": "HAQ-DI With VAS - Aids or Devices - Wheelchair (HAQ-DI Questionnaire Question)" + }, + { + "input": "Definition: Gene or Genome described as human CTRC wild-type allele is located in the vicinity of 1p36.21 and is approximately 11 kb in length. This allele, which encodes chymotrypsin-C protein, is involved in the proteolytic activation of other serine proteinases. Mutation of the gene is associated with hereditary pancreatitis.", + "output": "Chymotrypsin C (Caldecrin) wt Allele (CTRC gene)" + }, + { + "input": "Definition: Cell Component described as either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus.", + "output": "polar nucleus (Cell Component)" + }, + { + "input": "Definition: Food described as the oil extracted from the seeds of Brassica napus. Rapeseed oil was traditionally used as an industrial lubricant but newer varieties are used for animal feed, vegetable oil for human consumption, and biodiesel.", + "output": "rapeseed oil (Organic Chemical)" + }, + { + "input": "Definition: Health Care Related Organization described as a group formed in 1993 by four academic groups on a collaborative basis after informal discussions led to a common vision of how to achieve an important goal in the study of the human genome: the Integrated Molecular Analysis of Genomes and their Expression. They share high-quality, arrayed cDNA libraries and place sequence, map, and expression data on the clones in these arrays into the public domain. The human and mouse genomes were the first to be studied, and the collection now contains clones from rat, zebrafish, Fugu, Xenopus and rhesus macaque. They anticipate arraying (and sharing) cDNA libraries from additional species over time. A majority of their clones are publicly available, free of any royalties, and may be used by anyone agreeing with their guidelines.", + "output": "IMAGE Consortium (Professional Organization or Group)" + }, + { + "input": "Definition: Layer of plasma membrane described as part of plasma membrane which consists of an outer and inner layer of lipid molecules.", + "output": "Lipid bilayer of plasma membrane (Plasma membrane)" + }, + { + "input": "Definition: something described as the observed volume of distribution of the absorbed fraction associated with the terminal slope following extravascular administration, where F equals the fraction of dose absorbed, divided by the surface area.", + "output": "Volume of Distribution of Fraction Dose Observed Normalized by Surface Area (Observed Volume of Distribution of Absorbed Fraction)" + }, + { + "input": "Definition: Mechanical Ventilation Weaning Response: Adult described as collapse of part of a lung associated with absence of inflation (air) of that part.", + "output": "Atelectasis, NOS (Other disorders of lung)" + }, + { + "input": "Definition: Subfamily lentivirinae described as a non-taxonomic grouping of lentivuruses that infect cattle.", + "output": "Bovine Lentivirus Group (Genus: Lentivirus group)" + }, + { + "input": "Definition: something described as a subjective score of 7 on a severity scale that ranges from 0: Not at all severe to 10: most severe.", + "output": "Severity Score 7 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Corymbia described as lemon eucalyptus.", + "output": "Corymbia citriodora (Oils, Volatile)" + }, + { + "input": "Definition: Medicinal product categorized by structure described as manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat.", + "output": "Maneb product (Industrial fungicide)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Exposure to toxic substance (for example, dangerous chemicals, radiation): Part of my job.", + "output": "LEC0105D (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Unapproved attribute described as able to exist in combination.", + "output": "CW (Qualitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as extra data embedded in a document or metadata linked to a document which identifies and authenticates the signer of a document using public-key encryption.", + "output": "Digital Signature (Data Integrity)" + }, + { + "input": "Definition: NUP107 gene described as human NUP107 wild-type allele is located in the vicinity of 12q15 and is approximately 56 kb in length. This allele, which encodes nuclear pore complex protein Nup107, plays a role in nuclear transport.", + "output": "Nucleoporin 107kDa wt Allele (Gene or Genome)" + }, + { + "input": "Definition: ARF1 gene described as human ARF1 wild-type allele is located in the vicinity of 1q42.13 and is approximately 17 kb in length. This allele, which encodes ADP-ribosylation factor 1 protein, plays a role in intracellular protein trafficking.", + "output": "ARF1 wt Allele (ARF1 gene)" + }, + { + "input": "Definition: Serine/Threonine Protein Kinase Gene described as this gene is involved in diverse cell processes such as apoptosis, B cell activation and endothelial cell proliferation.", + "output": "protein kinase C beta (Gene or Genome)" + }, + { + "input": "Definition: Scleroderma and associated disorders described as an autoimmune disorder characterized by the association of primary biliary cirrhosis with limited cutaneous systemic sclerosis. Onset occurs between 30-65 years. Occurs sporadically, but rare familial cases with an unknown inheritance pattern have been observed. There is no cure and management is mainly supportive.", + "output": "REYNOLDS SYNDROME (Scleroderma and associated disorders)" + }, + { + "input": "Definition: Organic Chemical described as a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.", + "output": "Pixantrona (Organic Chemical)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of GUANINE NUCLEOTIDE EXCHANGE FACTORS that are specific for RAS PROTEINS.", + "output": "ras GEF (Biologically Active Substance)" + }, + { + "input": "Definition: Second generation cephalosporin described as the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28915\" active clinical trials using this agent.", + "output": "Cefoxitin Sodium (Second generation cephalosporin)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the spectrin beta, non-erythrocytic 2 (SPTBN2) gene, located at chromosome 11q13.2, which encodes the protein spectrin beta chain, non-erythrocytic 2. Genetic variants at this locus have been associated with spinocerebellar ataxia.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SPTBN2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Hypereosinophilic syndrome described as a rare myeloproliferative neoplasm characterized by a clonal proliferation of eosinophilic precursors resulting in persistently increased numbers of eosinophils in the blood, marrow and peripheral tissues. Since acute eosinophilic leukemia is at best exceedingly rare, the term eosinophilic leukemia is normally used as a synonym for chronic eosinophilic leukemia. In cases in which it is impossible to prove clonality and there is no increase in blast cells, the diagnosis of \"idiopathic hypereosinophilic syndrome\" is preferred.", + "output": "Chronic Eosinophilic Leukemia, NOS (Chronic leukemia)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in retroviral core structure.", + "output": "GAg gene, function (Gene or Genome)" + }, + { + "input": "Definition: something described as a country in Western Africa, bordering the North Atlantic Ocean, between Cote d'Ivoire and Sierra Leone.", + "output": "LR (Africa, Western)" + }, + { + "input": "Definition: Pharmaceutical Preparations described as any compound capable of activating the cannabinoid receptor CB1 and/or CB2. Cannabinoids include phytocannabinoids, endocannabinoids and (semi-)synthetic cannabinoids. They exert a wide variety of biological activities including anti-inflammatory, anti-emetic, anticonvulsant, antiglaucoma, analgesic and neuroprotective effects; while some exert psychoactive effects, including euphoria.", + "output": "cannabinoids (Medicinal product categorized by structure)" + }, + { + "input": "Definition: Sleep related movement disorder described as excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle.", + "output": "Myoclonus Syndrome, Nocturnal (Sleep related movement disorder)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 1660 of the coding sequence of the SDHA gene where cytosine has been mutated to thymine.", + "output": "Succinate Dehydrogenase Complex Flavoprotein Subunit A c.1660C>T (SDHA Gene Mutation)" + }, + { + "input": "Definition: neurofibroma described as a plexiform or diffuse neurofibroma arising from the bladder.", + "output": "Bladder Neurofibroma (Neoplastic Process)" + }, + { + "input": "Definition: something described as malignant tumor of bones which always arises in medullary tissue, occurring more often in cylindrical bones, with pain, fever, and leukocytosis.", + "output": "Ewing tumor (Sarcoma - category)" + }, + { + "input": "Definition: Health Care Activity described as acquires, interprets, and synthesizes patient cardiac data to detect and prevent potential adverse cardiac related clinical events.", + "output": "Manages changes in cardiac status (Physiologic Responses)" + }, + { + "input": "Definition: Leukoencephalopathy described as a rare genetic neurological disease characterised by the presence of fragile small-vessel intracerebral vasculature in various members of a single family. Clinical manifestations are single or recurrent haemorrhagic and/or ischaemic stroke and frequently ocular and renal involvement. Neuroimaging reveals diffuse periventricular leukoencephalopathy associated with dilated perivascular spaces, lacunar infarction and microhaemorrhages. There is evidence the disease is caused by heterozygous mutation in the COL4A1 gene on chromosome 13q34.", + "output": "Collagen type IV alpha 1 chain related familial vascular leucoencephalopathy (Vascular Diseases)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with any protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.", + "output": "splicing factor binding (Protein Binding)" + }, + { + "input": "Definition: something described as the date and/or date and time when the final participant in a clinical trial is enrolled.", + "output": "last subject in - date, time (Temporal Concept)" + }, + { + "input": "Definition: Analgoidea described as family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.", + "output": "Mite, Housedust (Analgoidea)" + }, + { + "input": "Definition: Musculoskeletal disorders congenital NEC described as a syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.", + "output": "turner kieser syndrome (Nail finding)" + }, + { + "input": "Definition: Finding described as greater than or equal to 10 percent decrease in the sum of longest diameters of target lesions but not a partial response.", + "output": "Minor Response (Finding)" + }, + { + "input": "Definition: Neoplastic Process described as grade III lymphomatoid granulomatosis that occurs in adulthood.", + "output": "adult grade III lymphomatoid granulomatosis (Adult Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: something described as a metered dose inhaler formulation of fluticasone-salmeterol drug combination.", + "output": "Advair HFA (Organic Chemical)" + }, + { + "input": "Definition: something described as the process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana.", + "output": "cellularization of the embryo sac (cellularization)" + }, + { + "input": "Definition: Plant described as a plant genus of the family ZINGIBERACEAE, order Zingiberales, subclass Zingiberidae. Elettaria cardamomum (L.) Maton is the source of Cardamom used in SPICES.", + "output": "Elettarias (Zingiberaceae)" + }, + { + "input": "Definition: Chimeric Antigen Receptor T-cells described as allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells.", + "output": "FMC63-28Z CAR-transduced Allogeneic T-lymphocytes (Cell)" + }, + { + "input": "Definition: Blood described as blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.", + "output": "fetal blood (Body Substance)" + }, + { + "input": "Definition: Pathologic Function described as in medicine, the change that a normal cell undergoes as it becomes malignant.", + "output": "Cell Transformation (Pathologic Function)" + }, + { + "input": "Definition: Diagnostic Accuracy Assessment Criterion described as the probability that an individual is not affected with the condition when a negative test result is observed. This measure of accuracy should only be used if the data on the prevalence of condition of interest in given population is available. NPVDT can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false negative results.", + "output": "Negative Predictive Values (Quantitative Concept)" + }, + { + "input": "Definition: something described as casework designed for use in clinical pharmacies. This furniture usually includes cabinets and shelves that are made of materials that protect against corrosion and strong chemicals; they are intended to store chemicals, medicines, glassware, and small instruments; some include sinks. Pharmacy casework is used in hospitals, nursing homes, and other healthcare facilities.", + "output": "Casework, Pharmacy (Medical Device)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, 30 Minute Delay Recall, Word 10.", + "output": "AVL01-List A 30 Min Delay Recall Word 10 (Intellectual Product)" + }, + { + "input": "Definition: Chronic disease of respiratory system described as a chronic form of sinusitis.", + "output": "Sinusitis, chronic (Other and unspecified diseases of upper respiratory tract)" + }, + { + "input": "Definition: Occupation or Discipline described as tree section heading for chemistry, physics, and related terms.", + "output": "physical sciences (Occupation or Discipline)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein encoded by the RET gene.", + "output": "RET Gene Product (Receptor Protein-Tyrosine Kinases)" + }, + { + "input": "Definition: Alopecia described as a rare multisystemic autoimmune disease mainly characterized by intermittent painful muscle spasms, alopecia (totalis or universalis in most cases) and long-lasting diarrhea that could lead to malnutrition, growth retardation, and amenorrhea. Secondary bone deformities and various endocrine anomalies may also be associated. Antinuclear antibodies are reported in many cases.", + "output": "Muscle spasms, intermittent with alopecia, diarrhea, and skeletal abnormalities (Alopecia)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days: How much has your health been a drain on the financial resources of you or your family?", + "output": "WHODAS 2.0 36-item Version Self-administered - Drain on Financial Resources (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: Flow Cytometry described as selection and deposition of individual cells of a particular phenotype from a mixed population into a separate tube or tissue culture plate by the use of a fluorescence-activated cell sorter (FACS) and fluorescently-labeled antibodies specific for surface molecules on the cells to be sorted. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C17353\" active clinical trials using this agent.", + "output": "Cell Sortings, Fluorescence-Activated (Cell Separation)" + }, + { + "input": "Definition: Standard Result Unit described as the standard unit of measure for body weight results.", + "output": "BWSTRESU (Standard Result Unit)" + }, + { + "input": "Definition: endonuclease described as specific phosphoric ester hydrolase (EC 3.1.30.1, EC 3.1.30.2, and EC 3.1.31.1) which restricts both RNA and DNA; for family of nucleic acid hydrolases, see the following see-term for \"nuclease (general).\"", + "output": "nuclease (endonuclease)" + }, + { + "input": "Definition: something described as the seventh rib counting from the top of the rib cage down.", + "output": "RIB 7 (Bone structure of rib)" + }, + { + "input": "Definition: Acute leukemia described as an aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow.", + "output": "ACUTE LYMPHOBLASTIC LEUKEMIA (Neoplasm by body site)" + }, + { + "input": "Definition: Eukaryote described as an order of ciliate protozoa. Characteristics include a dorsoventrally flattened, highly mobile body with a unique cursorial type of locomotion.", + "output": "Hypotrichia (Spirotrichea)" + }, + { + "input": "Definition: something described as this gene plays a role in proteolysis.", + "output": "HSRNASPH (Gene or Genome)" + }, + { + "input": "Definition: Mapped ICD-O Terminology described as the set of terms that have been mapped to terms with equivalent meaning in the International Classification of Disease for Oncology third edition first revision (ICD-O-3.1).", + "output": "Mapped ICD-O-3.1 Terminology (Mapped ICD-O Terminology)" + }, + { + "input": "Definition: Reagents described as an organic derivative of the unsaturated hydrocarbon stilbene, an aromatic alkene that is the nucleus of diethylstilbestrol and related compounds. Stilbene aldehyde is used in the chemical synthesis of estrogenic agents as well as for the manufacture of research reagents such as trans-stilbene oxide, a substrate for glutathione S-transferase. Estrogenic compounds containing the stilbene nucleus are known to be carcinogenic in humans and animals.", + "output": "Stilbene Aldehyde (Reagents)" + }, + { + "input": "Definition: Bone and Bones described as any short, irregular bone that is embedded in a tendon, and which functions to alter the direction of muscle pull, diminish friction, and modify pressure; sesamoid bones are found in various locations in the body, the largest of which is the patella.", + "output": "Sesamoid bone (Structure of short bone)" + }, + { + "input": "Definition: Pause Quantity described as a quantity of time that should elapse between when an activity is ready for execution and the actual beginning of the execution. EXAMPLE(S): Take a blood sample 15 minutes after administration of study drug or measure blood glucose 2 hours after each meal, the pauseQuantity would be 15 minutes and 2 hours respectively. For the more complex examples of doing activity A 5 minutes after the start of B or 5 minutes after the end of B, use pauseQuantity in combination with completionRequiredBeforeStartingIndicator where the pauseQuantity in both cases would be 5 minutes and \"after the start of\" would be completionRequiredBeforeStartingIndicator = \"N\" and \"after the end of\" = \"Y\". NOTE(S): The pauseQuantity defines the amount of time between two points in time: (1) the point when all preceding steps (in sequence) and preconditions of an activity have been completed, and (2) the actual start of the activity. The completion of all pre-conditions and preceding steps (based on sequence number) indicates that an activity is \"ready for execution\" according to the definition above. The pauseQuantity counter or timeclock starts then, and when the full amount of time is reached, the activity begins. A pauseQuantity with a negative value means that the activity starts some amount of time prior to the estimated time that the activity is \"ready for execution\", i.e. prior to the estimated time that the pre-conditions and preceding steps will be completed.", + "output": "Defined Contingent On Relationship Pause Quantity (Pause Quantity)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had problems learning about their medical condition because of difficulty understanding written information.", + "output": "How often do you have problems learning about your medical condition because of difficulty understanding written information (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Finding described as a numeric value corresponding to the degree of severity of an adverse event.", + "output": "Adverse Event Severity Grade (Adverse Event by Outcome and Action Criteria or Severity)" + }, + { + "input": "Definition: Disease or Syndrome described as a general class of thrombocytopenia due to immune destruction of platelets.", + "output": "immune thrombocytopenia (Thrombocytopenia)" + }, + { + "input": "Definition: Temporal Concept described as relating to or occurring during the period immediately before a surgical operation.", + "output": "Preoperative (Temporal Qualifier)" + }, + { + "input": "Definition: Medical Device described as susceptibility microbiological analyzers that perform the analysis with minimal involvement from the technician, using automation in most steps of the test procedure, including automated reading of the test, reduction of test data, and generation of an interpretation of the test results; most analyzers include integral incubators, and some also automate the culture preparation process. Most of these analyzers use photometric, fluorimetric or video-image analysis methods and include sample containers (e.g., vials, trays), a reader module to scan the containers, and a computer module for control and data processing.", + "output": "Analyzers, Laboratory, Microbiology, Susceptibility, Automated (Analyzers, Laboratory, Microbiology, Susceptibility)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as prostate cancer associated transcript 1 (~2 kb) is encoded by the human PCAT1 gene. This non-coding RNA may play a role in tumorigenesis.", + "output": "Prostate Cancer Associated Transcript 1 (Long Intergenic Non-Protein Coding RNA)" + }, + { + "input": "Definition: Neoplastic Process described as the tumor is found in one or both ovaries and has spread to other parts of the abdomen. Stage III is divided into stage IIIA, stage IIIB, and stage IIIC. In stage IIIA, the tumor is found only in the pelvis, but tumor cells have spread to the surface of the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen). In stage IIIB, the tumor has spread to the peritoneum but is 2 centimeters or smaller in diameter. In stage IIIC, the tumor has spread to the peritoneum and is larger than 2 centimeters in diameter and/or has spread to lymph nodes in the abdomen. The spread of tumor cells to the surface of the liver is considered stage III disease.", + "output": "ovarian tumors of low malignant potential, stage III (Neoplastic Process)" + }, + { + "input": "Definition: Finding of biliary tract described as impairment of bile flow due to obstruction in large bile ducts outside the liver.", + "output": "Extrahepatic Cholestasis (Finding of biliary tract)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.", + "output": "response to prostaglandin E stimulus (response to ketone)" + }, + { + "input": "Definition: Biotechnology described as methods of implanting a CELL NUCLEUS from a donor cell into an enucleated acceptor cell.", + "output": "nuclear transplantation (Research Techniques)" + }, + { + "input": "Definition: something described as a cytoarchitecurally defined area of cortex located most rostrally in the frontal lobe of the macaque ( Paxinos-2000 ). It has three subdivisions: area 10M of Paxinos, area 10D of Paxinos and area 10V of Paxinos. As with most parcellations of this area since the publication of Walker-1940, area 10 of Paxinos is topologically equivalent to area 10 of Walker, not to area 10 of Brodmann (guenon). The latter is different cytoarchitecturally and is more caudal, lateral and ventral in location. Walker renamed several areas of the macaque prefrontal cortex to coincide with the names Brodmann had given to cytoarchitecturally equivalent areas in the human ( Brodmann-1909 ).", + "output": "10 (Body Location or Region)" + }, + { + "input": "Definition: something described as data, facts or figures about an individual; the set of relevant items would depend on the use case.", + "output": "Personal Information (Information)" + }, + { + "input": "Definition: something described as a chromosome band present on 9q", + "output": "9q22.31 (Chromosome band)" + }, + { + "input": "Definition: something described as rivermead Post Concussion Symptoms Questionnaire - Compared with before the accident, do you now suffer from: Feeling frustrated or impatient.", + "output": "RPQ01-Feeling Frustrated or Impatient (Intellectual Product)" + }, + { + "input": "Definition: skeletal muscle relaxants described as the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.", + "output": "5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole hydrochloride (Antispasticity Agents)" + }, + { + "input": "Definition: Organ or Tissue Function described as the progression of the septum primum over time, from its formation to the mature structure.", + "output": "septum primum development (atrial septum development)" + }, + { + "input": "Definition: something described as an intracellular signaling adaptor protein that plays a role in TOLL-LIKE RECEPTOR and INTERLEUKIN 1 RECEPTORS signal transduction. It forms a signaling complex with the activated cell surface receptors and members of the IRAK KINASES.", + "output": "Toll Like Receptor Signal Adaptor Protein MyD88 (Immunologic Factor)" + }, + { + "input": "Definition: Date in time described as a date which indicates any data collected by this date will be used for analysis.", + "output": "Data Cutoff Date (Temporal Concept)" + }, + { + "input": "Definition: Hypophyseal diverticulum described as the slender tubular part of the hypophysial diverticulum; the stalk of Rathke's pocket.", + "output": "Hypophyseal duct (Pituitary Gland)" + }, + { + "input": "Definition: Tonsillar therapeutic procedures described as surgical removal of the pharyngeal tonsils (adenoids).", + "output": "Adenoid excision (Head and Neck Surgery)" + }, + { + "input": "Definition: Finding described as urothelial (transitional cell) carcinoma of the prostate with tumor invading other adjacent organs (invasion of the bladder).", + "output": "Urothelial (Transitional Cell) Carcinoma of the Prostate pT4 TNM Finding v7 (Urothelial (Transitional Cell) Carcinoma of the Prostate Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Pharmacologic Substance described as a neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.", + "output": "Oxidopamine (Hydroxydopamines)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of renal pelvis and ureter cancer, following the rules of the TNM AJCC v8 classification system.", + "output": "Renal Pelvis and Ureter Urothelial Carcinoma Clinical TNM Finding v8 (Finding)" + }, + { + "input": "Definition: carbon-oxygen lyase activity, acting on phosphates described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene.", + "output": "beta-curcumene synthase activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as environmental, occupational or consumer-based exposure to airborne gases and particulates produced by direct or nearby use of a vaporized or combusted product made from the leaves and flowers of the cannabis plant.", + "output": "Marijuana smoke (Finding)" + }, + { + "input": "Definition: Neoplastic Process described as a term that refers to the staging of hilar cholangiocarcinoma according to the American Joint Committee on Cancer, 8th edition. Hilar well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system.", + "output": "Hilar Cholangiocarcinoma by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Abnormality of the glabella described as posterior positioning of the glabella, i.e., of the midline forehead between the supraorbital ridges.", + "output": "Flat area between the eyebrows (Anatomical Abnormality)" + }, + { + "input": "Definition: Racks, Storage described as storage racks designed for temporarily holding and storing canes and/or crutches. These racks typically consist of an open heavy metal, wooden, and/or plastic framework with rails, bars, or hangers on which canes and/or crutches are hung; they may be wall-mounted or freestanding. Cane and/or crutch storage racks are used in hospitals, other healthcare facilities, and at home.", + "output": "Cane/Crutch Storage Racks (Medical Device)" + }, + { + "input": "Definition: Electrocardiogram finding described as an electrocardiographic finding of a compensatory supraventricular complex that occurs following a prolonged RR interval.", + "output": "SUPRAVENTRICULAR ESCAPE BEAT (Electrocardiogram finding)" + }, + { + "input": "Definition: Bayer Classification for Corneal Epitheliopathy described as epithelial opacities; micro-cysts; micro-deposits; corneal erosion; non-central stromal opacity.", + "output": "Bayer Corneal Epitheliopathy Grade 2 (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as forceps used to seize, cut, and collect biopsy specimens from tumors or other diseased tissue during surgical and diagnostic procedures. They typically are comprised of two joined handles, each attached to a sampling jaw (with smooth, serrated, or toothed-jaw cutting edges), and a stabilizing needle or spike between the sampling jaws to seize and stabilize the specimen. They can be reusable or single use.", + "output": "Biopsy forceps, device (Forceps)" + }, + { + "input": "Definition: Neoplastic Process described as a renal cell carcinoma with constitutional chromosome 3 translocations.", + "output": "Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations (Neoplastic Process)" + }, + { + "input": "Definition: Inflammatory disorder of head described as inflammation and enlargement of the lacrimal gland.", + "output": "Dacryoadenitides (Lacrimal Apparatus Diseases)" + }, + { + "input": "Definition: something described as brand name of quetiapine, a drug used to treat schizophrenia and bipolar disorder", + "output": "quetiapine (Branded drug names S to Sk)" + }, + { + "input": "Definition: negative regulation of nitrogen compound metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process.", + "output": "negative regulation of nitrogen cycle metabolic process (regulation of nitrogen cycle metabolic process)" + }, + { + "input": "Definition: Entity described as a named component of a data element. Usually the smallest component [ANSI]. See also data model, data element.", + "output": "data item (Entity)" + }, + { + "input": "Definition: something described as the negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells.", + "output": "maintenance of imaginal histoblast diploidy (Negative Regulation of Cell Differentiation)" + }, + { + "input": "Definition: ADP Ribose Transferases described as an enzyme that catalyzes the hydrolysis of nicotinamide adenine dinucleotide (NAD) to NICOTINAMIDE and ADENOSINE DIPHOSPHATE RIBOSE. Some are extracellular (ectoenzymes).The enzyme from some sources also catalyses the hydrolysis of nicotinamide adenine dinucleotide phosphate (NADP).", + "output": "NAD glycohydrolase (Hydrolase)" + }, + { + "input": "Definition: Bifurcation of trachea described as a ridge at the base of the trachea (windpipe) that separates the openings of the right and left main bronchi", + "output": "Structure of carina (Region of organ component)" + }, + { + "input": "Definition: Organic Chemical described as the chemical group =SO.", + "output": "Sulfoxide (Organic sulfur compound)" + }, + { + "input": "Definition: something described as human DKK1 wild-type allele is located in the vicinity of 10q11.2 and is approximately 4 kb in length. This allele, which encodes dickkopf-related protein 1, plays a role in the mediation of cell-cell signaling.", + "output": "DKK-1 (DKK1 gene)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as endoscopic surgical procedures performed with visualization via video transmission. When real-time video is combined interactively with prior CT scans or MRI images, this is called image-guided surgery (see SURGERY, COMPUTER-ASSISTED).", + "output": "video-assisted surgery (Endoscopy)" + }, + { + "input": "Definition: Finding described as a type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule.", + "output": "Age-related posterior subcapsular cataract (Senile cataract)" + }, + { + "input": "Definition: Immunoglobulin G measurement described as a classification of the amount of Betula verrucosa pollen IgG antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen.", + "output": "Betula verricosa Pollen IgG Antibody RAST Score Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as severe nail curvature, causing the tip of the nail to point downwards with respect to the axis of the finger. Beaked nails are caused by resorption of the distal digit.", + "output": "Beaked nails (Finding)" + }, + { + "input": "Definition: Medical Device described as supporting media consisting of gels (e.g., agarose gel) that are used in electrophoresis for supporting the migration of the charged particles.", + "output": "IVD Test Reagent/Kits, Electrophoresis, Supporting Media, Gel (Medical Device)" + }, + { + "input": "Definition: Reptile described as a subfamily of marine elapid snakes comprising about 50 species with flattened oar-like tails used as sculls. They are found mostly in the coastal waters of south Asia and Australia. The largest reach a length of almost 9 feet but most species are only about a third as long. They are all venomous.", + "output": "Sea Snake (Colubroidea)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.", + "output": "ribonuclease M5 activity (endoribonuclease activity, producing 5'-phosphomonoesters)" + }, + { + "input": "Definition: non-membrane-bounded organelle described as organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.", + "output": "intracellular non-membrane-enclosed organelle (intracellular organelle)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus.", + "output": "cellular response to differentiation-inducing factor 2 (Cell Function)" + }, + { + "input": "Definition: Hematopoietic system finding described as a laboratory test result that indicates the presence of abnormal peripheral blood and/or bone marrow values.", + "output": "Abnormal Hematology Test Result (Hematopoietic system finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase, thereby disrupting the regulation of cell proliferation and differentiation in a number of cells. This agent is also a selective human adenosine A3 receptor antagonist. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1335\" active clinical trials using this agent.", + "output": "1,3,4-Thiadiazole, 2-amino (Organic Chemical)" + }, + { + "input": "Definition: Dosage described as the highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by testing increasing doses on different groups of people until the highest dose with acceptable side effects is found.", + "output": "Dose, Maximally Tolerated (Dosage)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the Chlamydia trachomatis IgM antibody in a biological specimen.", + "output": "CTRIGMAB (Measurement of Chlamydia trachomatis antibody)" + }, + { + "input": "Definition: Neoplasms, Ductal, Lobular, and Medullary described as a small, often impalpable benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple.", + "output": "Papillomas, Intraductal (Neoplastic Process)" + }, + { + "input": "Definition: something described as porcupine tree.", + "output": "Sphingurus martini / porcupine tree (Homeopathic remedies letter S)" + }, + { + "input": "Definition: Cardiovascular system subdivision described as subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava.", + "output": "Systemic venous circulatory system (Cardiovascular system)" + }, + { + "input": "Definition: Finding described as suicide attempt or gesture without intent to die", + "output": "Grade 3 Suicide Attempt, CTCAE (Suicide Attempt, CTCAE)" + }, + { + "input": "Definition: Age Group described as age comparisons of behavioral, developmental, and cognitive variations between individuals or groups. Used for human or animal subjects.", + "output": "Age Differences (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Qualitative Concept described as any of the small, non-capital alphabetic letters.", + "output": "Lower Case Letter (Qualitative Concept)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with any androgen, male sex hormones.", + "output": "androgen binding (hormone binding)" + }, + { + "input": "Definition: something described as a Chinese person from the Ewenki ethnic group.", + "output": "EWENKI (Population Group)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a rare haemorrhagic disorder caused by congenital deficiency of alpha2 antiplasmin, leading to dysregulated fibrinolysis and is characterised by a haemorrhagic tendency presenting from childhood with prolonged bleeding and ecchymoses following minor trauma and spontaneous bleeding episodes. Inherited in an autosomal recessive manner.", + "output": "Congenital alpha2-antiplasmin deficiency (Congenital Disorders)" + }, + { + "input": "Definition: Neoplastic Process described as a benign or malignant neoplasm that affects the anal canal or anal margin.", + "output": "anus neoplasms (Digestive System Neoplasms)" + }, + { + "input": "Definition: Head described as frontal hairline with bilateral arcs to a low point in the midline of the forehead.", + "output": "Pointed frontal hairline (Hair)" + }, + { + "input": "Definition: Biologically Active Substance described as proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.", + "output": "heat-shock protein (Protein Family)" + }, + { + "input": "Definition: Chaperone Gene described as this gene is involved in the prevention of protein aggregation.", + "output": "heat shock protein family A (Hsp70) member 4 like (Gene or Genome)" + }, + { + "input": "Definition: Indo-Aryan Language described as an Indo-Aryan language spoken in the Northern-Eastern part of India and the Terai region of Nepal.", + "output": "Bhojpuri Language (Indo-Aryan Language)" + }, + { + "input": "Definition: Disorder of abdomen described as a primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas.", + "output": "Ovarian Ca (Woman)" + }, + { + "input": "Definition: other laboratory tests described as methods used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer.", + "output": "Enzymatic Assays (other laboratory tests)" + }, + { + "input": "Definition: something described as a blind-ending, epithelial-lined tract that is located less than 5 mm from the anal verge.", + "output": "Coccygeal Sinus (Sinus - general anatomical term)" + }, + { + "input": "Definition: Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 described as gastric neuroendocrine tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa.", + "output": "Gastric Neuroendocrine Tumor pT3 TNM Finding v8 (Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Organ or Tissue Function described as the surge of arterial blood felt by the finger or measured and recorded graphically; an indicator of heart rate and systolic force.", + "output": "pulse pressure wave (vasomotion)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of five subdivisions of the preoptic area defined on the basis of Nissl stain. It is a predominantly cellular structure located in the human adjacent to the third ventricle, rostral to the anterior commissure. There it is bounded dorsally by the dorsal subdivision of the preoptic periventricular nucleus and ventrally by the paraventricular nucleus of the hypothalamus ( Mai-2004 ); and it is located in the midline dorsal to the organum vasculosum ( Saper-2004 ). In the macaque ( Martin-2000; Paxinos-2009a ), the rat ( Swanson-1998 ) and the mouse ( Hof-2000 ) it is a narrow midline structure that wraps around the dorsal, rostral and ventral surfaces of the decussation of the anterior commissure.", + "output": "periventricular nucleus, preventricular portion (Preoptic Areas)" + }, + { + "input": "Definition: Connective Tissue Diseases described as disease of skin in someone with Lupus erythematosus, though not necessarily systemic or subacute.", + "output": "cutaneous lupus erythematosus (Noninfectious, erythematous, papular AND/OR squamous disease)" + }, + { + "input": "Definition: Plant Roots described as an enlarged portion of an underground stem (e.g., potato tubers, tulip bulbs, and iris rhizomes) that store food for the plant.", + "output": "Tuber, Plant (Plant Roots)" + }, + { + "input": "Definition: Health Care Activity described as verifies the exchange of patient information to ensure the coordination of appropriate and timely care, services and treatment and the prevention of patient harm throughout the perioperative phases of care. \"", + "output": "Evaluates continuity of care (Behavioral Responses: Patient and Family - Knowledge/Psychosocial)" + }, + { + "input": "Definition: something described as stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1a: Distant metastasis to lung. M1b: Metastasis to other distant sites.", + "output": "Stage IV Osteogenic Sarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Inflammatory disorder of breast described as a rare, benign, inflammatory breast disease occurring in premenopausal women shortly after a recent pregnancy. The origin is unknown but it is commonly mistaken for malignancy and sometimes associated with BREAST FEEDING and the use of ORAL CONTRACEPTIVES.", + "output": "Granulomatous mastitis (Mastitis)" + }, + { + "input": "Definition: Medical Device described as a flexible tube used to deliver fluids into or withdraw fluids from the body.", + "output": "CATHETER (Intracavitary Interventional Devices)" + }, + { + "input": "Definition: something described as anal cancer with distant metastasis.", + "output": "Anal Canal and Perianal (Anal Margin) Carcinoma cM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine antimyelin-associated glycoprotein antibodies (anti-MAG antibodies) in which activity is directed against peripheral nerve antigens. These antibodies are mostly found in chronic demyelinating or inflammatory neuropathies.", + "output": "IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antimyelin Antibody, MAG (Medical Device)" + }, + { + "input": "Definition: something described as a plant genus of the family POACEAE. The common name of wheatgrass is also used for other plants in the family.", + "output": "Agropyrons (Poaceae)" + }, + { + "input": "Definition: CD46 gene described as human CD46 wild-type allele is located in the vicinity of 1q32 and is approximately 43 kb in length. This allele, which encodes membrane cofactor protein, plays a role in the stimulation of T-regulatory cell differentiation, oocyte fertilization, the classical complement pathway and pathogen binding. Mutation of the gene is associated with increased susceptibility to hemolytic uremic syndrome.", + "output": "AHUS2 (CD46 gene)" + }, + { + "input": "Definition: Immunologic Factor described as autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.", + "output": "Neutrophil cytoplasmic antibody (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week, how often have you: taken care of work by yourself when it was necessary?", + "output": "QLES1-Taken Care of Work by Yourself (Intellectual Product)" + }, + { + "input": "Definition: Hypertensive emergency described as a condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.", + "output": "accelerated hypertension (Hypertensive emergency)" + }, + { + "input": "Definition: something described as a chromosome band present on 1p", + "output": "1p22-p21 (Cell Component)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - During the last 7 days, on how many days did you bicycle for at least 10 minutes at a time to go from place to place?: No bicycling from place to place.", + "output": "IPA03-No Bicycling From Place to Place (Intellectual Product)" + }, + { + "input": "Definition: Receptor described as specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.", + "output": "AVPR (Neuropeptide Receptor)" + }, + { + "input": "Definition: Ampulla of Vater Neuroendocrine Tumor described as a well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region. It produces somatostatin.", + "output": "Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor (Somatostatinoma)" + }, + { + "input": "Definition: Angiogenesis Inhibitors described as a proprietary preparation of mycobacterial DNA oligonucleotides embedded in mycobacterial cell wall fragments derived from cultures of Mycobacterium phlei, with potential immunomodulatory and antineoplastic activities. DNA oligonucleotides in the mycobacterial cell wall-DNA complex (MCC) are capable of inducing apoptosis by increasing BAX protein levels, releasing cytochrome C from mitochondria, and activating caspase-3 and -7. This leads to the cleavage of poly (ADP-ribose) polymerase and the release of nuclear matrix proteins (NuMA). In addition to its pro-apoptotic effect, MCC activates monocytes and macrophages to produce various cytokines, including interleukin 6 (IL-6), IL-8, IL-12, IL-18, and tumor necrosis factor alpha (TNF-a). This leads to an activation of natural killer cells and cytotoxic T lymphocytes and to interferon gamma (INF-g) synthesis, thereby attaining an anti-angiogenic effect.", + "output": "mycobacterial cell wall-DNA complex (Immunologic Adjuvants)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of cyclophosphamide vincristine, doxorubicin and dexamethasone, used as induction treatment for plasma cell myeloma.", + "output": "CVAD (Regimen Used to Treat Plasma Cell Myeloma)" + }, + { + "input": "Definition: something described as living in or surrounded by water with no significant amount of dissolved salt or minerals.", + "output": "fresh water environment (water environment)" + }, + { + "input": "Definition: Musculoskeletal System Part described as subdivision of head, each instance of which has as its constitutional part some viscerocranium (facial skeleton). Examples: There is only one face.", + "output": "Faces (Body part)" + }, + { + "input": "Definition: Intellectual Product described as a subtest of the Wechsler Adult Intelligence Scale, 4th Edition that measures processing speed, short-term visual memory, visual-motor coordination, cognitive flexibility, visual discrimination, psychomotor speed, and speed of mental operation. The subject scans a search group and indicates whether one of the symbols in the target group matches.", + "output": "WAIS-IV Symbol Search (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Epiphysis of bone described as the head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.", + "output": "Epiphysis, NOS (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a unit of concentration equal to femtogram per milliliter, divided by meters squared.", + "output": "Femtogram per Milliliter per Meter Squared (Quantitative Concept)" + }, + { + "input": "Definition: something described as a measurement of the broad casts in a biological specimen.", + "output": "Broad Casts (Laboratory Procedure)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5) gene, located at chromosome 3q27, which encodes for a subunit of EIF2B. EIF2B catalyzes the exchange of eukaryotic initiation factor 2-bound guanosine diphosphate (GDP) for guanosine triphosphate (GTP). Mutations at this locus have been identified in patients with leukoencephalopathy and ovarioleukodystrophy (vanishing white matter leukodystrophy with ovarian failure) and Cree leukoencephalopathy.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, EIF2B5 (Medical Device)" + }, + { + "input": "Definition: physical and chemical analysis and measurement described as image where signals are identified and separated according to their frequencies, e.g., to identify individual chemicals, or individual nuclei in a chemical compound.", + "output": "Spectrum Analysis (physical and chemical analysis and measurement)" + }, + { + "input": "Definition: Lobar bronchial tree described as a part the bronchial tree, arising from the primary bronchi, with each one serving as the airway to a specific lobe of the lung.", + "output": "Bronchi, Secondary (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure.", + "output": "cardiac jelly development (Organ or Tissue Function)" + }, + { + "input": "Definition: positive regulation of protein secretion described as any process that activates or increases the frequency, rate or extent of prolactin secretion.", + "output": "up regulation of prolactin secretion (positive regulation of protein secretion)" + }, + { + "input": "Definition: Finding described as no steatosis", + "output": "S0 (Finding)" + }, + { + "input": "Definition: Large neuron described as large branching neurons of the middle layer of cerebellar cortex, characterized by vast arrays of dendrites; involved in controlling complex movements.", + "output": "Purkinje neuron (Axonic neuron)" + }, + { + "input": "Definition: Endometrioid carcinoma of prostate described as a prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.", + "output": "Prostate Ductal Adenocarcinoma, Papillary Pattern (Infiltrating papillary adenocarcinoma)" + }, + { + "input": "Definition: BPRS-A Clinical Classification Question described as brief Psychiatric Rating Scale-A (BPRS-A) Uncooperativeness.", + "output": "BPRS-A - Uncooperativeness (Intellectual Product)" + }, + { + "input": "Definition: Molecular Chaperones described as membrane anchored lectin involved in the control of protein traficking through the endoplasmic reticulum and promotes correct folding of glycoproteins.", + "output": "CLN (Calcium-Binding Proteins)" + }, + { + "input": "Definition: Peritoneal and retroperitoneal disorders described as this entity represents the fibrotic stage of MESENTERY inflammation.", + "output": "Retractile mesenteritis (Peritoneal and retroperitoneal disorders)" + }, + { + "input": "Definition: Neuralgia described as a syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms.", + "output": "Trifacial Neuralgia (Fifth cranial nerve finding)" + }, + { + "input": "Definition: Genetic Function described as any process that modulates the frequency, rate or extent of mRNA metabolic process.", + "output": "regulation of mRNA metabolism (Genetic Function)" + }, + { + "input": "Definition: Lymphoid system structure described as segment of lymphoid system which has as its direct parts right lymphatic tree organ and thoracic duct tree. Examples: There is only one lymphatic system.", + "output": "Structure of lymphatic system (Hematopoietic and Lymphatic System Part)" + }, + { + "input": "Definition: negative regulation of mRNA metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process.", + "output": "downregulation of mRNA degradation (regulation of mRNA catabolic process)" + }, + { + "input": "Definition: Organic Chemical described as a polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.", + "output": "Nigericin (Antibiotic)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - The side effects of treatment are worse than I had imagined.", + "output": "FAC06131 (Intellectual Product)" + }, + { + "input": "Definition: Population Group described as the concept covering the physical and mental conditions of women.", + "output": "Womens health (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: something described as spine orthoses designed for external modification of the structural and/or functional characteristics of the lumbar and sacral segments of the spine, providing immobilization and support. These orthoses consist of a structure that encircles the lumbosacral part of the trunk to keep that segment of the spine constrained. Lumbosacral spine orthoses are intended mainly to alleviate low-back pain by providing immobilization (i.e., motion control) and/or support to the lumbar spine; they may consist of fabric and/or plastic either elastic, semi-rigid, or rigid devices. These orthoses may be used also as spinal supports for daily activities (i.e., functional) use.", + "output": "Lumbosacral Orthoses (Orthoses, Spine)" + }, + { + "input": "Definition: Antibiotic described as a very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.", + "output": "CMM (Antibiotic)" + }, + { + "input": "Definition: something described as ozone in the troposphere. It is considered a secondary air pollutant because it is produced by the reaction of solar ULTRAVIOLET RAYS with other AIR POLLUTANTS and because of its harmful effects on the respiratory system and the environment.", + "output": "Tropospheric Ozone (Chemical)" + }, + { + "input": "Definition: something described as a general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers.", + "output": "SOLUTION, CLARKE'S (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the ESR1 gene.", + "output": "ESR Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) Global functioning scale.", + "output": "PODCI1-Global Functioning Scale (PODCI Pediatric Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Health Services described as care of children in the home or institution; for the raising of one's own children or parenting use CHILD REARING", + "output": "puericulture (Health Services)" + }, + { + "input": "Definition: Finding described as cutaneous melanoma with two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No.", + "output": "Melanoma of the Skin cN2b TNM Finding v8 (Cutaneous Melanoma cN2 TNM Finding v8)" + }, + { + "input": "Definition: Abnormality of the distal phalanx of the 5th finger described as patchy increase in bone density of the distal phalanx of the 5th finger.", + "output": "Uneven increase in bone density in the outermost bone of pinkie finger (Patchy sclerosis of distal phalanx of finger)" + }, + { + "input": "Definition: lutein metabolic process described as the chemical reactions and pathways resulting in the breakdown of lutein.", + "output": "lutein catabolic process (xanthophyll catabolic process)" + }, + { + "input": "Definition: Regimen Used to Treat Hodgkin Lymphoma described as a non-cross resistant regimen in which half of the MOPP regimen is administered with half of the ABV regimen and is used for the initial treatment of Hodgkin lymphoma (HL). The regimen contains mechlorethamine, vincristine, procarbazine and prednisone (MOPP) and doxorubicin, bleomycin, vinblastine (ABV).", + "output": "MOPP-ABV hybrid protocol (Regimen Used to Treat Hodgkin Lymphoma)" + }, + { + "input": "Definition: Apolipoproteins A described as the most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.", + "output": "apo a-i (Apolipoproteins A)" + }, + { + "input": "Definition: Canis familiaris described as a small spaniel with a short, broad face, and a soft, feathered coat. A thick ruff covers the neck and chest. The nose is wide and the nostrils open. The upside-down, v-shaped ears are well covered with hair. The coat may be white with colored patches, most often black, but is sometimes red, yellow, orange, sable, or brindle. The average height range is 7-11 inches and the weight is up to 9 pounds.", + "output": "Japanese Chin (Mammal)" + }, + { + "input": "Definition: Hand deformities described as divergence of the longitudinal axis of the hand at the wrist in a posterior (ulnar) direction (i.e., towards the little finger).", + "output": "Ulnar deviation of hands (Finding)" + }, + { + "input": "Definition: Flower Essences described as california wild rose.", + "output": "rosa californica/california (Flower Essences)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the anterior portion of the mid-cavity division of the left ventricular myocardium as determined using the AHA 17-Segment Model (Cerqueira et al., 2002).", + "output": "LEFT VENTRICULAR MID ANTERIOR SEGMENT (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a synthetic bis-ethyl analogue of spermine with potential antineoplastic activity. N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT). Polyamines, an integral part of the DNA helix structure, play a critical role in cell division, differentiation and membrane function. Disruption of normal polyamine concentrations by DENSPM may lead to cell growth inhibition.", + "output": "BENSpm (Pharmacologic Substance)" + }, + { + "input": "Definition: C4 complement assay described as the determination of the amount of complement C4d present in a sample.", + "output": "Complement C4d Measurement (C4 complement assay)" + }, + { + "input": "Definition: something described as a term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system.", + "output": "Liver Cell Carcinoma by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Criminal Rehabilitation described as an institution where persons are confined for punishment and to protect the public.", + "output": "Penitentiary (Criminal Rehabilitation)" + }, + { + "input": "Definition: Proteins described as naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue, differs from chondroitin sulfate A by containing iduronic acid in place of glucuronic acid, its epimer, at carbon atom 5.", + "output": "Sulfate B, Chondroitin (Other antithrombotic agents in ATC)" + }, + { + "input": "Definition: Added heart sounds described as a sharp, high-pitched click heart sound that indicates heart valve disease", + "output": "opening snap (auscultation of heart sounds)" + }, + { + "input": "Definition: Liver and Intrahepatic Biliary Tract Carcinoma described as a rare carcinoma that arises from the intrahepatic bile ducts and is composed of malignant glandular cells and malignant squamous cells.", + "output": "Liver Adenosquamous Carcinoma (Liver and Intrahepatic Biliary Tract Carcinoma)" + }, + { + "input": "Definition: something described as a kappa-opioid receptor agonist with edema relieving activity. Niravoline inhibits the scretion of the antiduretic hormone vasopressin thereby causing a diuretic effect.", + "output": "NIRAVOLINE (Pharmacologic Substance)" + }, + { + "input": "Definition: Regulation or Law described as the fundamental principles and laws adopted by an organization for the regulation and governing of its affairs.", + "output": "CONSTITUTION BYLAWS (Regulation or Law)" + }, + { + "input": "Definition: something described as a specimen derived from a tumor-adjacent normal tissue specimen that was collected from the subject after treatment with a neoadjuvant therapeutic.", + "output": "Tumor Adjacent Normal - Post Neo-adjuvant Therapy (Post Neoadjuvant Therapy Sample)" + }, + { + "input": "Definition: Laboratory instruments and equipment described as sinks designed for cleaning and manipulation of laboratory devices, instruments, and supplies. These sinks typically consist of one or more non-absorbent and resistant to acids, salts, and solvents bowls (e.g., made of epoxy resin or stainless steel) with a seamless, without crevices, and rounded corner construction that includes several faucets, cold, hot, and deionized water supply, soap dispensers, and appropriate tubing for drainage. The sinks may also include exhaust ducts for connection to the building ventilation system and a waste bin. They are usually operated using hand and/or foot pedals. Clinical laboratory sinks are available as stand alone units or more frequently to be mounted on standard laboratory cabinets. Stand-alone bigger, deeper, and wider laboratory sinks intended to wash glassware are also available.", + "output": "Laboratory Sinks (Medical Device)" + }, + { + "input": "Definition: Manufactured Object described as facilities which provide care for infants.", + "output": "nurseries (Manufactured Object)" + }, + { + "input": "Definition: something described as none of the choices above are suitable.", + "output": "None of the Above (Finding)" + }, + { + "input": "Definition: 17-alpha-hydroxyprogesterone described as a synthetic progestational agent similar to the endogenous progesterone used in hormone therapy or as a female contraceptive. Mimicking the action of progesterone, hydroxyprogesterone caporate binds to and activates nuclear progesterone receptors in the reproductive system and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. Due to the negative feedback mechanism seen with progesterone, this agent also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impeding the growth of estrogen-sensitive tumor cells.", + "output": "Oxyprogesterone Caproate (generic drug products begining with the letter H)" + }, + { + "input": "Definition: Qualitative Concept described as WHO Technical Report Series, No.953, 2009. Stability testing of active pharmaceutical ingredients and finished pharmaceutical products.", + "output": "WHO Temperature/Humidity Storage Condition (Storage Condition)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene plays a role in cellular homeostasis by transcription modulation. The gene is also involved in V(D)J recombination.", + "output": "HYRC1 (Gene or Genome)" + }, + { + "input": "Definition: Acereae described as a plant genus of the family SAPINDACEAE, best known for trees with palmately lobed leaves.", + "output": "Genus Acer (Plant)" + }, + { + "input": "Definition: Biological Response Modifiers described as a topical cellular cytokine solution containing a distinct combination of growth factors and cytokines secreted by and released from amnion-derived multipotent progenitor (AMP) cells, with potential immunomodulating and skin healing activities. The amnion-derived cellular cytokine solution (ACCS) contains near physiological levels of transforming growth factor beta, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2, as well as the angiogenesis factors platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and angiogenin that are normally found in healing wounds. Upon spraying the solution onto affected areas, the cytokines and growth factors in ACCS appear to increase the migration, proliferation and differentiation of both keratinocytes and fibroblasts; enhance the migration and phagocytosis of macrophages in wounds; and increase epithelialization. Together these processes may accelerate skin healing and tissue repair. Also, ACCS may be beneficial in the treatment of radiation burns of the skin. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C103921\" active clinical trials using this agent.", + "output": "ACCS (Pharmacologic Substance)" + }, + { + "input": "Definition: Stage I Testicular Cancer AJCC v6 and v7 described as stage IB includes: (pT2, N0, M0, S0); (pT3, N0, M0, S0); (pT4, N0, M0, S0). pT2: Tumor limited to the testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis. pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion. pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. S0: Marker study levels within normal limits.", + "output": "Stage IB Testicular Cancer (Neoplastic Process)" + }, + { + "input": "Definition: something described as this gene plays a role in cell-cell and cell-extracellular matrix interactions.", + "output": "CD11d (Cell Adhesion Molecule Gene)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla.", + "output": "renal outer medulla development (anatomical structure development)" + }, + { + "input": "Definition: Zoonoses described as viral infections that may be transmitted between non-human animals and HUMANS.", + "output": "Viral Zoonotic Infection (Zoonoses)" + }, + { + "input": "Definition: Intellectual Product described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Severe human suffering: Not sure.", + "output": "LEC0113E (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+).", + "output": "leukotriene-E4 omega-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Social/Family Well-Being: I get emotional support from my family.", + "output": "FAC015-Get Emotional Support From Family (Intellectual Product)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the RAND Social Support Survey Instrument (RAND Social Support Survey) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "CDISC Questionnaire RAND Social Support Survey Test Name Terminology (Intellectual Product)" + }, + { + "input": "Definition: plastic property described as resistance and recovery from distortion of shape.", + "output": "Elasticity (Characteristics)" + }, + { + "input": "Definition: Regulatory Protein described as tomoregulin-2 (374 aa, ~41 kDa) is encoded by the human TMEFF2 gene. This protein may play a role in the positive regulation of cell growth and cell survival.", + "output": "TMEFF2 (Regulatory Protein)" + }, + { + "input": "Definition: Episodic Ataxia described as an extremely rare form of hereditary episodic ataxia with characteristics of recurrent episodes of vertigo and ataxia lasting several hours.", + "output": "Episodic ataxia type 5 (Disease or Syndrome)" + }, + { + "input": "Definition: something described as any substance that inhibits serine/threonine protein kinase, an enzyme that phosphorylates the hydroxyl group of serine or threonine on various proteins in various signaling cascades. Inhibition of serine/threonine protein kinase can inhibit cell proliferation and induce apoptosis.", + "output": "Serine/Threonine Kinase Inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+.", + "output": "2-aminobenzoyl-CoA monooxygenase/reductase activity (Molecular Function)" + }, + { + "input": "Definition: Lobule described as a triangular-shaped unit of hepatic tissue, containing portions of three adjacent hepatic lobules with the portal canal in the center. The portal canal is composed of the portal vein, hepatic artery, bile ductile, and lymph vessel. There is a central vein at the apex of each peripheral corner. Blood flows from the portal vein and hepatic artery towards the central vein. Bile flows in the opposite direction, towards the portal canal.", + "output": "Portal Lobule (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Medical Device described as prepackaged collections of the devices and supplies (either custom or standard) needed for performing a soft tissue biopsy procedure. Items in these kits usually include Luer lock syringes, needles, anesthetics, scalpel, specimen tubes with caps, microscope slides, and a ruler; kits may also include gauze pads, towels, a fenestrated drape, and adhesive bandages. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Soft tissue biopsy procedure kits and trays are intended for use during the removal of a small sample of soft tissue (e.g., skin, fat, muscle, tendon) for microscopic (in-vitro) laboratory examination.", + "output": "Procedure Kit/Trays, Biopsy, Soft Tissue (Procedure Kit/Trays, Biopsy)" + }, + { + "input": "Definition: something described as a unit of allergenic product potency expressed as the number of standardized quality units per one milliliter of formulation.", + "output": "{SQU}/mL (Quantitative Concept)" + }, + { + "input": "Definition: Toxoplasmosis described as acquired as an adult.", + "output": "Adult Acquired Toxoplasmosis (Toxoplasmosis)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of paromomycin.", + "output": "paromomycin biosynthesis (paromomycin metabolic process)" + }, + { + "input": "Definition: Transcription Factors, General described as transcription initiation factor TFIID subunit 2 (1199 aa, ~136 kDa) is encoded by the human TAF2 gene. This protein plays a role in the initiation of transcription.", + "output": "TAFII-150 (Transcription Factors, General)" + }, + { + "input": "Definition: Finding described as t2a (patch only).", + "output": "Mycosis Fungoides and Sezary Syndrome T2a TNM Finding v8 (Mycosis Fungoides and Sezary Syndrome T2 TNM Finding v8)" + }, + { + "input": "Definition: something described as the production of antigen and antibody detection components.", + "output": "Production of Immunoassay Detection Reagent (Laboratory Procedure)" + }, + { + "input": "Definition: Set of lobular organs of head described as accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.", + "output": "Minor salivary glands set (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a fusion protein encoded by the ZMYM2/FGFR1 fusion gene. This protein is comprised of the 10 zinc finger protein dimerization motifs from the zinc finger MYM-type protein 2 followed by the tyrosine kinase domains of the basic fibroblast growth factor receptor 1.", + "output": "ZMYM2-FGFR1 Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: something described as the determination of the number of hypersegmented neutrophils present in a sample.", + "output": "HYPSEGCE (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a capsule containing a fermented soymilk extract and oligomeric proanthocyanidins (OPCs), green tea, spirullina, curcumin and antrodia camphorate powder, with potential antioxidant, immunomodulating, anti-infective and anti-cancer activities. OPCs/green tea/spirullina/curcumin/antrodia camphorate/fermented soymilk extract capsule may boost the immune system and may alleviate fatigue and poor appetite in cancer chemotherapy patients.", + "output": "OPCs/Green Tea/Spirullina/Curcumin/Antrodia Camphorate/Fermented Soymilk Extract Capsule (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a person or organization that receives or is intended to receive a report.", + "output": "ReportReceiver (Organization)" + }, + { + "input": "Definition: Protein Complex Subunit Gene described as this gene is plays a role in subcellular protein targeting and the post-translational modification of certain proteins.", + "output": "GGTI (Protein Complex Subunit Gene)" + }, + { + "input": "Definition: something described as a chemoimmunotherapy regimen consisting of cisplatin and cetuximab used for the treatment of unresectable squamous cell head and neck cancer.", + "output": "Cisplatin-Cetuximab Regimen (Regimen Used to Treat Malignant Head and Neck Neoplasm)" + }, + { + "input": "Definition: something described as a method of ultrasound imaging that uses a linear pattern of beams to produce a standard, two dimensional image.", + "output": "2-Dimensional Single Plane Ultrasound Mode (Functional Concept)" + }, + { + "input": "Definition: Oxidoreductase described as thioredoxin (105 aa, ~12 kDa) is encoded by the human TXN gene. This protein plays a role in redox reactions, signaling and immunity.", + "output": "TRX protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Finger joint structure described as a ginglymoid (hinge) synovial joint between the phalanges of the fourth digit of the hand.", + "output": "Interphalangeal Joint 4 of the Hand (Finger joint structure)" + }, + { + "input": "Definition: something described as a disorder characterized by an infectious process involving a joint.", + "output": "Joint Infection, CTCAE (Finding)" + }, + { + "input": "Definition: H3C7 gene described as human H3C7 wild-type allele is located in the vicinity of 6p22.2 and is approximately 1 kb in length. This allele, which encodes histone H3.1 protein, is involved in DNA compartmentalization.", + "output": "H3f (H3C7 gene)" + }, + { + "input": "Definition: something described as a question associated with the PDDS questionnaire.", + "output": "PDDS Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as enzyme preparations are products that are used in the histopathology laboratory for the following purposes: (1) To disaggregate tissues and cells already in established cultures for preparation into subsequent cultures (e.g., trypsin); (2) To disaggregate fluid specimens for cytological examination (e.g., papain for gastric lavage or trypsin for sputum liquefaction); (3) To aid in the selective staining of tissue specimens (e.g., diastase for glycogen determination).", + "output": "Neuraminidase (Hydrolase)" + }, + { + "input": "Definition: Bone neoplasms described as new abnormal growth of tissue in the SPINE.", + "output": "neoplasm of vertebra (Central Nervous System)" + }, + { + "input": "Definition: Adrenal Gland Composite Pheochromocytoma described as a composite pheochromocytoma that is confined to the adrenal gland and does not have any metastatic potential.", + "output": "Benign Adrenal Gland Composite Pheochromocytoma (Benign pheochromocytoma of adrenal gland)" + }, + { + "input": "Definition: Pre-Eclampsia described as toxemia occurring in women in the second half of their pregnancy, characterized by hypertension, and usually by edema and proteinuria, but without the convulsions and coma associated with eclampsia.", + "output": "Pre-eclampsia, NOS (Diagnosis/Diseases Component)" + }, + { + "input": "Definition: Hound described as a sweet, mellow, sociable, and lean hound with a broad head, a domed skull, soft low-hung ears, and dark-brown eyes. This dog is a hunter with a loud, ringing bark. The average height range is 23-26 inches and the average weight range is 45-65 pounds.", + "output": "American English Coonhound (Mammal)" + }, + { + "input": "Definition: Integrity described as a condition of data reflecting the degree to which the data are complete, consistent, accurate, trustworthy, and reliable at any given time as well as consistently so maintained throughout the data life cycle. NOTE: The data should be collected and maintained in a secure manner, so that they are Attributable, Legible, Contemporaneously recorded, Original (or a true copy) and Accurate (ALCOA). Assuring data integrity requires appropriate quality and risk management systems, including adherence to sound scientific principles and good documentation practices. (After MHRA Guidance on \"GxP data integrity\") See also ALCOA, ALCOA+, traceability (data). Compare to data quality.", + "output": "Data Integrity (security integrity)" + }, + { + "input": "Definition: Attitude described as individual's experience of a sense of fulfillment of a need or want.", + "output": "Fulfillment (Attitude)" + }, + { + "input": "Definition: positive regulation of molecular function described as any process that activates or increases the frequency, rate or extent of signaling receptor activity.", + "output": "positive regulation of signaling receptor activity (positive regulation of molecular function)" + }, + { + "input": "Definition: Manufactured Object described as supporting structures (i.e., docks) designed to provide connectivity to laptop portable computers and/or for automated charging of their internal rechargeable batteries. These docks (also known as docking stations) typically consist of a structure made of metal, hard plastic, or a combination of these that is usually placed on a tabletop. The docks hold and provide appropriate connectors to plug in the laptop computer, facilitating their connectivity and/or providing means to recharge their internal batteries. The docks may also include wired or wireless connection to other devices such as peripheral equipment (e.g., monitors, printers) and information systems facilitating the download of data, a power converter (e.g., 120 VAC to 12 VDC), and a line cord for connection to the mains.", + "output": "Laptop Computers Dock/Battery Chargers (Manufactured Object)" + }, + { + "input": "Definition: regulation of postsynaptic density organization described as any process that activates or increases the frequency, rate or extent of postsynaptic density organization.", + "output": "up regulation of PSD organization (Cell Function)" + }, + { + "input": "Definition: something described as total vessel occlusion. (Gibson, C. M., de Lemos, J. A., Murphy, S. A., Marble, S. J., McCabe, C. H., Cannon, C. P., Antman, E. M., Braunwald, E. Combination therapy with abciximab reduces angiographically evident thrombus in acute myocardial infarction: a TIMI 14 substudy Circulation. 2001;103(21):2550-4.)", + "output": "CORONARY THROMBUS TIMI GRADE 5 (TIMI Coronary Thrombus Grade)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.", + "output": "methylglyoxal metabolic process (cellular ketone metabolic process)" + }, + { + "input": "Definition: Chromosome 19 Physical Location described as physical location of AZU1_Gene", + "output": "19: 778831-783017 (Chromosome 19 Physical Location)" + }, + { + "input": "Definition: Metabolic Pathways of Other Amino Acids described as the chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.", + "output": "glutathione metabolic process (Sulfur Metabolism Pathway)" + }, + { + "input": "Definition: Aminoaciduria described as increased amount of argininosuccinate in the urine.", + "output": "Deficiencies, Arginino Succinase (Amino Acid Metabolism, Inborn Errors)" + }, + { + "input": "Definition: Cell described as a preparation of allogeneic, donor-derived T-lymphocytes that are specific for a unique set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface of malignant cells, with potential immunomodulating and antineoplastic activities. T-lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT) donor. Ex vivo, these T-cells are exposed to and primed against a select set of host-specific hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T-lymphocytes, these cells target and bind to MiHA antigens expressed on the host's leukemia cells, thereby killing these cancer cells. MiHA are small, cell-surface peptides that are associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells.", + "output": "anti-MiHA donor T lymphocytes (Cell)" + }, + { + "input": "Definition: carbohydrate derivative metabolic process described as the cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.", + "output": "nucleotide-sugar metabolism (carbohydrate derivative metabolic process)" + }, + { + "input": "Definition: cellular component assembly described as the formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.", + "output": "tonofilament assembly (intermediate filament organization)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6).", + "output": "L-cysteine catabolic process via cystine, using cystine reductase (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual feels or felt misunderstood by their spouse or significant other.", + "output": "Feeling misunderstood by spouse/significant other (Intellectual Product)" + }, + { + "input": "Definition: Structure of inferior pancreaticoduodenal lymph node described as inferior pancreaticoduodenal lymph node located on the posterior aspect of inferior region of head of pancreas.", + "output": "No. 13b pancreaticoduodenal lymph node (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as an inherited disorder in which there is a lower-than-normal number of neutrophils (a type of white blood cell that is important in fighting infections). Infants with the disorder get infections caused by bacteria, and are at an increased risk of acute myelogenous leukemia (AML) or myelodysplasia (a bone marrow disorder).", + "output": "Low blood neutrophil level since birth (Quantitative abnormality of granulocytes)" + }, + { + "input": "Definition: Medical Device described as immunohistochemistry test systems (IHC's) are in vitro diagnostic devices consisting of polyclonal or monoclonal antibodies labeled with directions for use and performance claims, which may be packaged with ancillary reagents in kits. Their intended use is to identify, by immunological techniques, antigens in tissues or cytologic specimens. Similar devices intended for use with flow cytometry devices are not considered IHC's.", + "output": "KIT, ASSAY, ESTROGEN RECEPTOR (Medical Device)" + }, + { + "input": "Definition: positive regulation of proteasomal protein catabolic process described as any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.", + "output": "upregulation of proteasomal ubiquitin-dependent protein catabolic process (positive regulation of proteasomal protein catabolic process)" + }, + { + "input": "Definition: Protein-Serine-Threonine Kinases described as serine/threonine-protein kinase MARK2 (788 aa, ~88 kDa) is encoded by the human MARK2 gene. This protein plays a role in both microtubule dynamics and serine/threonine phosphorylation.", + "output": "ELKL Motif Kinase (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Anatomy Qualifier described as a term that refers to the biliary tract structures.", + "output": "biliary (Anatomy Qualifier)" + }, + { + "input": "Definition: something described as symptoms of Major Depressive Disorder Scale v1.0 test code.", + "output": "QS-SMDDS Version 1.0 TESTCD (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: 4 Stair Ascend Functional Test Question described as four Stair Ascend Test (4 Stair Ascend) Did subject wear orthoses?", + "output": "A4STR103 (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as an inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.", + "output": "Nonerosive Arthritis (Disease or Syndrome)" + }, + { + "input": "Definition: something described as increase in the chance of developing a disease, due to hormonal factors.", + "output": "Hormonal Risk Factor (risk factors)" + }, + { + "input": "Definition: Calbindins described as a calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.", + "output": "Calbindin 2 (Calbindins)" + }, + { + "input": "Definition: Surgical sutures described as sutures made of synthetic polymer fiber threads. These sutures may be made of absorbable (i.e., biodegradable) or nonabsorbable (i.e., non biodegradable) materials; typically, absorbable sutures are made of polyglycolic acid and derivatives, lactic acid, or caprolactone, while nonabsorbable sutures are made of more common polymers (e.g., polypropylene, polyester, nylon). The type of synthetic suture used depends on the size and location of the wound, the strength and period of use required, cosmetic effect desired, and/or other clinical or physical needs. Synthetic sutures usually have a smooth surface but some sutures are made of barbed threads. Barbed thread sutures are mainly used to suture without using knots (also known as knotless sutures); they can also be used for cosmetic procedures (e.g., face-lifting, cosmetic breast lifting). Synthetic sutures are typically available in sterile sections (e.g., 18, 30 inches/45, 76 cm long) attached to a single-use needle as an integral device; they are frequently colored for easy identification during surgery.", + "output": "Synthetic Sutures (Medical Device)" + }, + { + "input": "Definition: Chemical Modifier described as products containing allergenic substances used for allergy diagnosis or treatment.", + "output": "allergen (Antigens)" + }, + { + "input": "Definition: FACIT-Fatigue 13-Item Version 4 Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Fatigue 13-Item Scale Version 4 - I need to sleep during the day.", + "output": "FACIT-Fatigue 13-Item Version 4 - I Need to Sleep During the Day (Intellectual Product)" + }, + { + "input": "Definition: Protein Translocation Systems described as universally conserved multiprotein complexes that form the protein transport channel of the general secretory (SEC) pathway. The SEC translocase is present in all bacteria, archaea, and eukaryotes. It is in the ENDOPLASMIC RETICULUM membrane of eukaryotic cells, in the THYLAKOID MEMBRANE in CHLOROPLASTS and in some protozoa in the INNER MITOCHONDRIAL MEMBRANE.", + "output": "Translocon, SEC (Protein Translocation Systems)" + }, + { + "input": "Definition: something described as the lead has been left in situ but is not in use.", + "output": "ABANDONED (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a group of closely related heterogeneous-nuclear ribonucleoproteins of approximately 41-43 kDa in size found in the cell nucleus. Members of this class have been implicated in a variety of processes including splicing, polyadenylation, and nuclear retention of RNA.", + "output": "C-Type Protein HnRNP (Heterogeneous-Nuclear Ribonucleoproteins)" + }, + { + "input": "Definition: Streptococcus mutans group described as any bacterial organism that can be assigned to the species Streptococcus mutans.", + "output": "mutans streptococcus (Streptococcus viridans group)" + }, + { + "input": "Definition: something described as a chromosome band present on 6p", + "output": "6p21.1-p12.2 (Chromosome band)" + }, + { + "input": "Definition: US State described as state bounded on the north by Oklahoma, on the east by Arkansas and Louisiana, on the south by Mexico, and on the west by New Mexico.", + "output": "TX (Region of United States of America)" + }, + { + "input": "Definition: Name described as the name of a medical product, practice, or application reported in a clinical trial.", + "output": "Procedure Agent Reported Name (Intellectual Product)" + }, + { + "input": "Definition: Bacteriophages described as viruses whose host is Bacillus. Frequently encountered Bacillus phages include bacteriophage phi 29 and bacteriophage phi 105.", + "output": "Bacteriophage, Bacillus (Virus)" + }, + { + "input": "Definition: something described as the different gene transcripts generated from a single gene by RNA EDITING or ALTERNATIVE SPLICING of RNA PRECURSORS.", + "output": "RNA Isoforms (RNA)" + }, + { + "input": "Definition: Enzyme described as aminopeptidase N (967 aa, ~110 kDa) is encoded by the human ANPEP gene. This protein plays a role in the mediation both of peptide hydrolysis and infection by certain viruses.", + "output": "Antigen CD13 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Component described as the region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.", + "output": "nucleoid (Cell Component)" + }, + { + "input": "Definition: phosphoric diester hydrolase activity described as catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+.", + "output": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity (phosphoric diester hydrolase activity)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as the biotoxin alpha-conotoxin GIA.", + "output": "Alpha-Conotoxin GIA (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO.", + "output": "aldehyde decarbonylase activity (carbon-carbon lyase activity)" + }, + { + "input": "Definition: del(10q23) described as a cytogenetic abnormality that refers to the deletion of the chromosomal band 10q23, which also results in the deletion of the PTEN gene.", + "output": "10q23/PTEN Locus Deletion (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Pharmacologic Substance described as the sodium salt of the dextro isomer of lactic acid with alkalinizing and electrolyte replenishing property. Upon metabolism, sodium lactate D is converted to bicarbonate, thereby increasing plasma bicarbonate, which facilitates removal of hydrogen ion and lactate from blood stream and leads to raised blood pH.", + "output": "Sodium Lactate, D- (Electrolyte Replacement Agent)" + }, + { + "input": "Definition: something described as the lower one third of the esophagus in which the muscle layer is composed of muscle cells predominantly of the smooth type.", + "output": "Lower third of oesophagus (Esophagus)" + }, + { + "input": "Definition: something described as cx9C motif-containing protein 4 (68 aa, ~8 kDa) is encoded by the human CMC4 gene. This protein plays a role in cellular proliferation.", + "output": "MTCP1 (Cell Cycle Proteins)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Has there been a time when you started to do something to try to end your life but someone or something stopped you before you actually did anything? (Prior to Study Entry).", + "output": "CSS05-Interrupted Attempt-Prior (C-SSRS Already Enrolled Subjects Questionnaire Question)" + }, + { + "input": "Definition: something described as this gene is involved in the function of natural killer cells.", + "output": "UL16-BINDING PROTEIN 3 (Genes, Regulator)" + }, + { + "input": "Definition: Finding described as personal actions to prepare and ingest food and fluid independently with or without assistive device", + "output": "the ability to eat with out any help (Finding)" + }, + { + "input": "Definition: Serratia described as a species of facultatively anaerobic, Gram negative, rod shaped bacteria in the phylum Proteobacteria. This species is motile, peritrichous, decarboxylase positive, citrase negative and can support growth on and produce acid from adonitol, arabinose, arabitol, melibiose, a methylglucoside, rhamnose, sorbitol and xylose. S. ficaria is associated with figs and fig wasps, and is a cause of gallbladder empyemas and sepsis in areas that cultivate fig trees.", + "output": "Serratia vespertilionis Garcia-Fraile et al. 2015 (Bacterium)" + }, + { + "input": "Definition: Acute Erythroblastic Leukemia described as cancer of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.", + "output": "erythroleukemia (Neoplastic Process)" + }, + { + "input": "Definition: Ability to produce voice described as a term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).", + "output": "aphonia (Voice production finding)" + }, + { + "input": "Definition: Magnetic resonance imaging contrast media described as an injectable, intravascular, amphiphilic gadolinium-based contrast agent (GBCA) used with magnetic resonance angiography (MRA) imaging. Gadofosveset is a stable gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) chelate derivative with a diphenylcyclohexylphosphate group. Upon injection, gadofosveset binds reversibly to endogenous serum albumin which increases its intravascular retention time compared to non-protein binding contrast agents. The serum albumin binding also increases T1-relaxivity of gadofosveset. This produces an increase in signal intensity of blood, thereby enhancing the visualization of blood vessels upon MRA and may aid in the diagnosis of certain blood vessels and heart disorders.", + "output": "Product containing gadofosveset (Gadolinium compound)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) These are more questions about your cough and shortness of breath these days: I am short of breath when I talk.", + "output": "SGRQ01-Short of Breath When I Talk (Intellectual Product)" + }, + { + "input": "Definition: Plant Roots described as an enlarged underground root or stem of some plants. It is usually rich in carbohydrates. Some, such as POTATOES, are important human FOOD. They may reproduce vegetatively from buds.", + "output": "Tubers (Plant Part)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.", + "output": "mitochondrial protein-transporting ATPase activity (Molecular Function)" + }, + { + "input": "Definition: Research Personnel described as a researcher at a study site who oversees multiple aspects of the study at a site, including protocol submission for IRB approval, participant recruitment, informed consent, data collection, and analysis. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Study Site Investigator (Research Personnel)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare complex type of hereditary spastic paraplegia with characteristics of the onset in childhood/adolescence (ages 2-19) of progressive spastic paraplegia associated mainly with mild to moderate cognitive impairment and developmental delay, cerebellar ataxia, dysarthria, and peripheral neuropathy. Less commonly reported manifestations include skeletal abnormalities (i.e. pes cavus, scoliosis), dyskinesia, dystonia, cataracts, cerebellar signs (i.e. saccadic dysfunction, nystagmus, dysmetria) and bladder disturbances. SPG26 is caused by mutations in the B4GALNT1 gene (12q13.3), encoding Beta-1, 4 N-acetylgalactosaminyltransferase 1.", + "output": "familial spastic paraplegia autosomal recessive type 26 (Complicated hereditary spastic paraplegia)" + }, + { + "input": "Definition: Protein translocation described as the process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system.", + "output": "protein secretion by the type VII secretion system (Protein translocation)" + }, + { + "input": "Definition: Hemopoietic stem cell transplant described as a procedure in which a patient receives blood-forming stem cells (cells from which all blood cells develop) donated by his or her healthy identical twin.", + "output": "syngeneic stem cell transplantation (Hemopoietic stem cell transplant)" + }, + { + "input": "Definition: something described as a chromosome band present on 1p", + "output": "1p22.1 (Chromosome band)" + }, + { + "input": "Definition: Mammal described as a tiny dog with a big personality and an apple-shaped head and a short pointed muzzle. It has round, large, very dark eyes and trademark large ears. The body is cobby (stout) and is longer than it is tall. The coat is short, soft and glossy; colors include fawn, sand, chestnut, silver and steel blue, black, tan, and parti-color. The average height range is 6-9 inches and the average weight range is 2-6 pounds.", + "output": "Smooth Chihuahua (Chihuahua superbreed)" + }, + { + "input": "Definition: Radioconjugate described as a radiotracer composed of a bone targeting agent P15-041 linked to the radioisotope gallium Ga 68, with potential imaging activity upon positron emission tomography (PET)/computed tomography (CT). Upon administration, the P15-041 moiety targets, through an as of yet unknown mechanism of action, a certain target expressed by bone and, upon PET/CT, bone metastases can be imaged. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C129713\" active clinical trials using this agent.", + "output": "gallium Ga 68 P15-041 (Pharmacologic Substance)" + }, + { + "input": "Definition: Means described as written instructions for doing a specific task in a certain way. In clinical trials, SOPs are set up to store records, collect data, screen and enroll subjects, and submit Institutional Review Board (IRB) applications and renewals.", + "output": "SOP (Means)" + }, + { + "input": "Definition: Central Nervous System described as loss of previously present mental and motor abilities.", + "output": "Psychomotor degeneration (Mental deterioration)" + }, + { + "input": "Definition: Conjunctival Melanoma cT2 TNM Finding v8 described as conjunctival melanoma with caruncular tumor, and 1 or less quadrant of the nonbulbar conjunctiva involved.", + "output": "Conjunctival Melanoma cT2c TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as decrease in threonine content of the diet compared to the assessed baseline intake of threonine for the individual.", + "output": "Decrease in threonine content of the diet compared to the assessed baseline intake of threonine for the individual. (Threonine modified diet)" + }, + { + "input": "Definition: Histamine H2 receptor antagonists for peptic ulcer and GORD described as a competitive and reversible histamine H2-receptor antagonist with antacid activity. Nizatidine inhibits the histamine H2-receptors located on the basolateral membrane of the gastric parietal cell, thereby reducing basal and nocturnal gastric acid secretion, resulting in a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli.", + "output": "Nizatidine-containing product (N [Preparations])" + }, + { + "input": "Definition: Congenital anomaly of bone and joint described as asymmetric head shape, which is usually a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape.", + "output": "Asymmetric head (Disorder of skull)" + }, + { + "input": "Definition: Cytokine Measurement described as the determination of the amount of interleukin 32 present in a sample.", + "output": "INTLK32 (Laboratory Procedure)" + }, + { + "input": "Definition: something described as this group is composed predominantly of the lymph nodes located along the lower half of the spinal accessory nerve and the transverse cervical artery. The supraclavicular nodes also are included in the posterior triangle group. The superior boundary is the apex formed by the convergence of the sternocleidomastoid and trapezius muscles; the inferior boundary is the clavicle; the anterior (medial) boundary is the posterior border of the sternocleidomastoid muscle; and the posterior (lateral) boundary is the anterior border of the trapezius muscle. Thus, sublevel VA includes the spinal accessory nodes, whereas sublevel VB includes the nodes following the transverse cervical vessels and the supraclavicular nodes, with the exception of the Virchow node, which is located in level IV. The posterior triangle nodes are at greatest risk for harboring metastases from cancers arising from the nasopharynx, oropharynx, and cutaneous structures of the posterior scalp and neck.", + "output": "Posterior Triangle Lymph Node Group (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Genes described as genes that determine the fate of a cell or CELLS in a region of the embryo during EMBRYONIC DEVELOPMENT.", + "output": "Gene, Developmental (Genes)" + }, + { + "input": "Definition: something described as the reemergence of a malignant neoplasm of the stomach after a period of remission.", + "output": "Malignant neoplasm of stomach recurrent (Recurrent Malignant Neoplasm)" + }, + { + "input": "Definition: Subdivision of gut described as section of the alimentary canal from the stomach to the anus; includes the large and small intestines.", + "output": "Intestinal tract (DIGESTIVE SYSTEM: GENERAL TERMS)" + }, + { + "input": "Definition: Other Finding described as a finding referring to a medical device that has been removed from the body, usually during a surgical procedure.", + "output": "Inactive (Other Finding)" + }, + { + "input": "Definition: Enterobacteriaceae described as a species of facultatively anaerobic, Gram-negative, rod shaped bacteria in the phylum Proteobacteria. This species is motile using peritrichous flagella, non-spore forming, indole and urease negative, noncapsulated, produces a yellow pigment, liquefies gelatin, reduces nitrate, hydrolyzes esculin, and is Voges-Proskauer reaction positive. P. agglomerans is found on plant surfaces, seeds, and water and is pathogenic in humans and some strains can be pathogenic to plants.", + "output": "Enterobacter agglomerans (Pantoea)" + }, + { + "input": "Definition: something described as very severe edema (skin shiny and tight with or without skin cracking).", + "output": "Stern's Edema Rating 4 (Stern's Rating Scale for Edema)" + }, + { + "input": "Definition: HAMD 24 Clinical Classification Question described as hamilton Depression Rating Scale 24 Item - Psychomotor agitation.", + "output": "HAMD3-Psychomotor Agitation (Intellectual Product)" + }, + { + "input": "Definition: Stage IIIC Cervical Cancer FIGO 2018 described as cervical carcinoma with para-aortic lymph node metastasis.", + "output": "Stage IIIC2 Cervical Cancer FIGO 2018 (Neoplastic Process)" + }, + { + "input": "Definition: Echocardiography described as a procedure that uses sound waves to measure characteristics of disturbed bood flow, such as direction, velocity and turbulence. This enables the examiner to differentiate between normal and abnormal flow patterns and, in some cases, to quantitate those characteristics that are helpful in determining the severity of abnormal flow states.", + "output": "ECHOCARDIOGR DOPPLER (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as a group of Uralic languages spoken by the Sami people in Northern Europe.", + "output": "Sami Language (Uralic language)" + }, + { + "input": "Definition: something described as a benign or malignant neoplasm that affects the structures of the mediastinum. Representative examples include mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma.", + "output": "Tumour of mediastinum (Mediastinal Diseases)" + }, + { + "input": "Definition: Curettage procedure described as a surgical scraping and removal of the inner lining of the uterus through direct dilation of the uterine cervix.", + "output": "Dilation and curettage of uterus, NOS (Operation on cervix)" + }, + { + "input": "Definition: Domestic mammal described as the domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago.", + "output": "Feline, NOS (Felis catus)" + }, + { + "input": "Definition: Prostate Cancer Clinical Distant Metastasis TNM Finding v7 described as prostate cancer without evidence of distant metastasis.", + "output": "Prostate Cancer cM0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as the tissue that lines the wall of the abdominal cavity, intestine, mesentery, and pelvic organs. It consists of the parietal peritoneum and the visceral peritoneum.", + "output": "Peritoneal (Serous Membrane)" + }, + { + "input": "Definition: something described as a cytogenetic abnormality that refers to a translocation involving the TFEB gene.", + "output": "TFEB Translocation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how often an individual has experienced sharp pains in their breast area.", + "output": "How Often Experienced Sharp Pains in Your Breast Area (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Genetic Function described as the process whereby a guanine in a tRNA is methylated at the N2 position of guanine.", + "output": "tRNA N2-guanine methylation (Genetic Function)" + }, + { + "input": "Definition: Murine-human monoclonal immunoglobulin G antibody described as a drug used to treat autoimmune disorders", + "output": "MAb cA2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: BACTERIA AND RICKETTSIAE described as a genus of aerobic, helical spirochetes, some species of which are pathogenic, others free-living or saprophytic.", + "output": "Leptospira (SUBCLASS SPIROCHETES)" + }, + { + "input": "Definition: Lipase Increased, CTCAE described as >2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic", + "output": "Grade 3 Lipase Increased, CTCAE (Finding)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.", + "output": "enterobacter ribonuclease activity (Genetic Function)" + }, + { + "input": "Definition: Hypolipidemic Agents described as a hydrochloride salt form of colestipol, a positively charged, non-digestible, triamine and epoxypropane copolymer anion-exchange resin that binds to bile acids in the intestine to form an insoluble complex, which is excreted in the feces.", + "output": "Colestipol hydrochloride [dup] (Polyamines)" + }, + { + "input": "Definition: Spatial Concept described as physical location of GTF2B_Gene", + "output": "1: 89069241-89030638 (Chromosome 1 Physical Location)" + }, + { + "input": "Definition: Neoplastic Process described as a non-invasive adenocarcinoma arising from a tubulovillous adenoma.", + "output": "Adenocarcinoma In Situ in Tubulovillous Adenoma (In situ neoplasm)" + }, + { + "input": "Definition: PTH gene described as human PTH wild-type allele is located within 11p15.3-p15.1 and is approximately 4 kb in length. This allele, which encodes parathyroid hormone protein, plays a role in calcium homeostasis. Mutation or aberrant expression of this gene can result in hypoparathyroidism.", + "output": "PTH wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Telomere Maintenance described as the process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.", + "output": "T loop biosynthesis (Genetic Function)" + }, + { + "input": "Definition: Clinical Trial Objective described as the exploratory purpose of the trial.", + "output": "OBJEXP (Idea or Concept)" + }, + { + "input": "Definition: Finding described as major salivary gland cancer with tumor 2 cm or less in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.", + "output": "Major Salivary Gland Cancer pT1 TNM Finding v8 (Major Salivary Gland Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Gene Amplification Abnormality described as a molecular genetic abnormality indicating the presence of multiple copies of the KRAS gene.", + "output": "c-K-ras Gene Amplification (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: pT category finding described as a pathologic primary tumor TNM stage finding. The definition of pT2 stage finding depends on the particular type of cancer that it refers to; for example, for breast cancer, pT2 stage finding is defined as follows: cancer with tumor size more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for colorectal cancer, pT2 stage finding is defined as follows: cancer with invasion into the muscularis propria.", + "output": "Tumor Stage pT2 (Finding)" + }, + { + "input": "Definition: St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) Best describe how your respiratory problems affect you.", + "output": "SGRQ0251 (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)" + }, + { + "input": "Definition: Nitroso Compounds described as nitrosylated derivatives of guanidine. They are used as MUTAGENS in MOLECULAR BIOLOGY research.", + "output": "Nitrosoguanidines (Organic Chemical)" + }, + { + "input": "Definition: stem cell fate determination described as the cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.", + "output": "neuroblast fate determination (Cell Function)" + }, + { + "input": "Definition: Bacteroides described as a non-taxonomic grouping of bacteria that belongs to the fragilis group of the genus Bacteroides.", + "output": "Bacteroides fragilis Group (Bacteroides)" + }, + { + "input": "Definition: something described as prostate cancer with metastasis to bone(s).", + "output": "Prostate Cancer pM1b TNM Finding v7 (Prostate Cancer pM1 TNM Finding v6 and v7)" + }, + { + "input": "Definition: Finding described as ENA (Extractable Nuclear Antigen): a complex antigen mixture extracted from calf thymus nuclei by isotonic buffer, containing primarily ribonucleoprotein (RNP) and Sm antigen.", + "output": "ENA +, titer 1: (ENA: extractable nuclear antigen antibody)" + }, + { + "input": "Definition: Gastroscopes described as gastroscopes with a nonflexible (i.e., rigid) structure that can only follow a straight path through the upper gastrointestinal tract. They include illumination and imaging systems that enable the examination of the esophagus and stomach. The sheath is usually made of stainless steel.", + "output": "Gastroscopes, Rigid (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the MLL/CBL fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal proline-rich region and ubiquitin-binding leucine zipper domain of the E3 ubiquitin-protein ligase CBL protein.", + "output": "MLL-CBL Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Postoperative Period described as the period of emergence from general anesthesia, where different elements of consciousness return at different rates.", + "output": "Recovery Period, Anesthesia (Anesthesia and Analgesia)" + }, + { + "input": "Definition: Neoplastic Corticotroph Cell described as a neoplastic faintly basophilic or chromophobic PAS-positive and weakly ACTH-positive cell with scant and small secretory granules seen at the ultrastructural level.", + "output": "Neoplastic Corticotroph Cell with Scarce Secretory Granules (Cell)" + }, + { + "input": "Definition: FGFR Family Alteration Positive described as an indication that mutation, overexpression, fusion or rearrangement involving the FGFR1 gene has been detected in a sample.", + "output": "FGFR1 Gene Alteration (Laboratory or Test Result)" + }, + { + "input": "Definition: Medical Device described as automated brachytherapy applicators designed to deliver therapeutic radioactive sources to, retrieve them from, and/or hold them in (natural or surgically created) interstices or cavities of the body. These applicators typically include hollow needles, catheters, and/or cannulae and are frequently configured for use according to the treatment site within the body (e.g., brain, bladder, biliary ducts, breast). Some applicators include a catheter with a balloon at the tip that is left in a surgical cavity (e.g., after extraction of a breast lump); several treatments are performed after surgery by introducing a radioactive source (i.e., seed) into the balloon through a catheter for a predetermined period of time. The radioactive source is delivered by a remote afterloading brachytherapy system. Interstitial/intracavitary automated brachytherapy applicators are typically used to treat malignant tumors in internal tissue (e.g., sarcoma) and/or organs.", + "output": "Interstitial Brachytherapy Automated Applicators (Medical Device)" + }, + { + "input": "Definition: something described as human IHH wild-type allele is located within 2q33-q35 and is approximately 6 kb in length. This allele, which encodes indian hedgehog protein, plays a role in both bone growth and differentiation. Mutations in this gene are associated with acrocapitofemoral dysplasia and brachydactyly, type A1.", + "output": "HHG2 (IHH gene)" + }, + { + "input": "Definition: meclofenamate described as the sodium salt form of meclofenamate, an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Meclofenamate sodium inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of meclofenamate sodium. Meclofenamate sodium also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47597\" active clinical trials using this agent.", + "output": "Meclonax (Pharmacologic Substance)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.", + "output": "cell junction organisation (Cell Function)" + }, + { + "input": "Definition: Finding described as a finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.", + "output": "Lymphocyte Count Decreased (Investigations, CTCAE)" + }, + { + "input": "Definition: Manufactured Object described as testers designed to measure and assess the electrical and/or mechanical characteristics of electrical power supply receptacles. These testers are used to assess the safety of receptacles used as outlets for electric power lines in healthcare facilities.", + "output": "Testers, Power, Outlet (Tester device)" + }, + { + "input": "Definition: child in-law described as the wife of your son.", + "output": "Daughter-in-law (In-law)" + }, + { + "input": "Definition: something described as an enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. This enzyme exists in two forms: an active phosphorylated form ( PHOSPHORYLASE A) and an inactive un-phosphorylated form (PHOSPHORYLASE B). Both a and b forms of phosphorylase exist as homodimers. In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue.", + "output": "Glycogen Phosphorylase (Phosphorylases)" + }, + { + "input": "Definition: regulation of transport described as any process that modulates the frequency, rate or extent of galactotriose transport.", + "output": "regulation of galactotriose transport (regulation of transport)" + }, + { + "input": "Definition: RouteBySite described as a route that begins within the abdomen.", + "output": "Intraabdominal Route of Administration (RouteBySite)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was able to think clearly and solve day to day problems.", + "output": "Able to think clearly and solve day to day problems (Finding)" + }, + { + "input": "Definition: regulation of glycogen biosynthetic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "output": "negative regulation of glycogen biosynthesis (negative regulation of glycogen metabolic process)" + }, + { + "input": "Definition: something described as a mesenchymal neoplasm arising from the pilar sheath of the hair follicle.", + "output": "Pilar-Associated Mesenchyme Neoplasm (Hair Follicle Neoplasm)" + }, + { + "input": "Definition: Physical & Psychosomatic Disorders described as a cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.", + "output": "cataracts (Acquired Abnormality)" + }, + { + "input": "Definition: something described as a combination agent composed of the benzo-poly-carbonic-acid polymer BP-Cx1 chelated to platinum with potential antineoplastic activity. Upon intramuscular injection, the polymer moiety of BP-Cx1-Platinum Complex BP-C1 (BP-C1) alters the permeability of the cell membranes, which allows for increased penetration of platinum into tumor cells. In turn, platinum binds to nucleophilic groups such as GC-rich sites in DNA and induces intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. In addition, the BP-Cx1 ligand is able to stimulate the innate immune system and upregulates a variety of cytokines including interferon, tumor necrosis factor-alpha (TNF-alpha), granulocyte macrophage-colony stimulating factor (GM-CSF), and various interleukins (ILs) such as IL-6 and IL-25. In comparison to cisplatin and other platinum-based compounds, treatment with BP-C1 allows for less platinum administration, which reduces platinum-associated systemic toxicity and side effects, and enhances the safety profile while maintaining or improving its efficacy.", + "output": "BP-C1 (Pharmacologic Substance)" + }, + { + "input": "Definition: penicillins described as a semisynthetic penicillin with antibacterial activity. Pirbenicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.", + "output": "6-(D-2-phenyl-2-(N-4-pyridylformimidyl aminoacetamido)acetamido)penicillanic acid (penicillins)" + }, + { + "input": "Definition: something described as a categorization of breeds by ICDC.", + "output": "Breed Group (ICDC Terminology)" + }, + { + "input": "Definition: something described as laboratory clinical chemistry analyzers that require the manual insertion of reagents and/or samples into the instrument for each test. Most of these chemical analyzers are used to determine concentrations of analytes (e.g., cholesterol, glucose, electrolytes), to provide certain hematology values (e.g., hemoglobin concentrations), and to assay some therapeutic drugs (e.g., theophylline). Manual clinical chemistry analyzers are used as primary instrumentation, for small volume tests, or as backup for automated analyzers.", + "output": "Clinical Chemistry Analyzers, Manual (Clinical chemistry analyzer)" + }, + { + "input": "Definition: Limb structure described as underdevelopment of the proximal epiphysis of the femur.", + "output": "Underdevelopment of the innermost thighbone end part (Finding)" + }, + { + "input": "Definition: Medical procedure on respiratory tract described as administering an inhalant(s) into a client/patient's nose, trachea and/or respiratory system. Service is billed per treatment.", + "output": "ADMIN INHALATION (drug management)" + }, + { + "input": "Definition: Genetic Function described as the encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full.", + "output": "viral DNA genome packaging, headful (Genetic Function)" + }, + { + "input": "Definition: CDISC Functional Test Terminology described as test names of functional test questions associated with the mini-mental state examination (MMSE) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).", + "output": "MMS1TN (CDISC Functional Test Terminology)" + }, + { + "input": "Definition: something described as a solution or suspension composed of active and/or inert ingredient(s) with increased strength in a reduced volume, which is usually diluted prior to administration.", + "output": "Conc (Dosage Forms)" + }, + { + "input": "Definition: Gene or Genome described as human BCL5 gene is located in the vicinity of 17q22 and is approximately 2 kb in length. This phenotype-only gene has not been linked to a known protein product. This locus may play a role in hematopoiesis. Chromosomal rearrangements involving this gene locus may be associated with both aberrant expression of the MYC gene and leukemia.", + "output": "B-Cell CLL/Lymphoma 5 Gene (Genes, Regulator)" + }, + { + "input": "Definition: Molecular Function described as combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH.", + "output": "lactoferrin receptor activity (cargo receptor activity)" + }, + { + "input": "Definition: Energy work described as using a combination of energy medicine and talk therapy with a client to concurrently identify and clear physical, emotional, psychological and/or spiritual imbalances. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.", + "output": "Integral practice therapy each 15 minutes (Energy work)" + }, + { + "input": "Definition: Sclerosis of finger phalanx described as an elevation in bone density in one or more phalanges of the fifth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.", + "output": "Increased bone density in pinkie finger bone (Sclerosis of finger phalanx)" + }, + { + "input": "Definition: something described as anatomic structures forming the upper respiratory tract and upper part of the digestive tract. They include the oral cavity, sinonasal tract, pharynx, pyriform sinus, larynx, trachea, and esophagus.", + "output": "Upper aerodigestive tract structure (Head and neck structure)" + }, + { + "input": "Definition: something described as a period in a clinical study during which information about the health status of an individual is obtained after study procedures and treatments have concluded.", + "output": "FOLLOW-UP (follow-up)" + }, + { + "input": "Definition: something described as a transforming growth factor beta2 (TGF-beta2) antisense gene-modified allogeneic tumor cell vaccine with potential immunostimulatory and antineoplastic activities. Belagenpumatucel-L is prepared by transfecting allogeneic non-small cell lung cancer (NSCLC) cells with a plasmid containing a TGF-beta2 antisense transgene, expanding the cells, and then irradiating and freezing them. Upon administration, this agent may elicit a cytotoxic T lymphocyte (CTL) response against host NSCLC cells, resulting in decreased tumor cell proliferation; vaccine immunogenicity may be potentiated by suppression of tumor TGF-beta2 production by antisense RNA expressed by the vaccine plasmid TGF-beta2 antisense transgene. Elevated levels of TGF-beta2 are frequently linked to immunosuppression in cancer patients and may be inversely correlated with prognosis in patients with NSCLC. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73438\" active clinical trials using this agent.", + "output": "lucanix (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus.", + "output": "Secondarily generalized tonic-clonic status epilepticus (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes.", + "output": "geranyldiphosphate metabolic process (Phospholipid Metabolism)" + }, + { + "input": "Definition: nit remover described as a reagent comprised of the organic chemical formic acid that cleaves proteins into peptides at the C- or N-terminal side of an aspartate residue.", + "output": "formic acid (F [Preparations])" + }, + { + "input": "Definition: NCI Thesaurus Role described as a role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively.", + "output": "Chemical Or Drug Affects Cell Type Or Tissue (NCI Thesaurus Role)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cardiotrophin-like cytokine factor 1 (225 aa, ~25 kDa) is encoded by the human CLCF1 gene. This protein is involved in cytokine signaling.", + "output": "Cardiotrophin-Like Cytokine Factor 1 (Immunologic Factor)" + }, + { + "input": "Definition: Qualitative Concept described as the type of a material sample taken from a biological entity for microbiological testing.", + "output": "MBSPEC (Qualitative Concept)" + }, + { + "input": "Definition: Lesion of testis described as inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation.", + "output": "Testicular inflammation (Testicular and epididymal infections and inflammations)" + }, + { + "input": "Definition: Medicinal product categorized by structure described as a topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect.", + "output": "5-Aminolevulinic acid (Sensitizers used in photodynamic/radiation therapy)" + }, + { + "input": "Definition: Biologically Active Substance described as granulin from the sixth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin D or epithelin 4.", + "output": "Epithelin 4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.", + "output": "positive regulation of triglyceride biosynthetic process (regulation of triglyceride biosynthetic process)" + }, + { + "input": "Definition: something described as a rare benign neoplasm that arises from the intrahepatic bile ducts. It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma.", + "output": "Biliary Adenofibroma (Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm)" + }, + { + "input": "Definition: Structured Product Labeling Marketing Category described as a category specifying that a product is marketed as unapproved vitamin product.", + "output": "Marketed as Unapproved Vitamin Product (Structured Product Labeling Marketing Category)" + }, + { + "input": "Definition: Organism Function described as the process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form.", + "output": "dorsal motor nucleus of vagus nerve morphogenesis (Organism Function)" + }, + { + "input": "Definition: something described as surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.", + "output": "choledochostomies (Construction of external stoma)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid preparation, usually multidose, consisting of an emulsion in a pressurised container with a spray valve or in a container equipped with a spray pump, intended for cutaneous use.", + "output": "Cutaneous spray, emulsion (Biomedical or Dental Material)" + }, + { + "input": "Definition: Molecular Function described as the process of introducing a phosphate group into dCDP to produce a dCTP.", + "output": "dCDP phosphorylation (Molecular Function)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as an extremely rare metabolic disorder characterized clinically by skin discoloration, elevated levels of carotene and low levels of vitamin A described in fewer than 5 patients to date. There is evidence that the disease is caused by heterozygous mutation in the BCMO1 gene on chromosome 16q23.", + "output": "Hereditary hypercarotenemia and vitamin A deficiency (Inborn Errors of Metabolism)" + }, + { + "input": "Definition: Purine analog-containing product described as the active ingredient in a drug that is used to treat chronic lymphocytic leukemia (CLL), to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs, and is being studied in the treatment of other types of cancer. Bendamustine may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite.", + "output": "Bendamustina (Alkylating Agents)" + }, + { + "input": "Definition: something described as catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.", + "output": "prolylprotocollagen hydroxylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a loss of the ability to move the vocal fold on one side.", + "output": "unilateral paralysis vocal cord (Larynx)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to swallow food.", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Hard to Swallow Food (Intellectual Product)" + }, + { + "input": "Definition: something described as a terminology codelist relevant to the type of primary outcome or endpoint that the protocol is designed to evaluate.", + "output": "CDISC SDTM Trial Type Terminology (CDISC SDTM Terminology)" + }, + { + "input": "Definition: response to peptide described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.", + "output": "response to polypeptide hormone stimulus (Cell Function)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane.", + "output": "positive regulation of membrane permeability (regulation of membrane permeability)" + }, + { + "input": "Definition: Wounds and Injuries described as an injury sustained while practicing or competing in a sport.", + "output": "INJ ATHLETIC (GENERAL INJURIES)" + }, + { + "input": "Definition: Thyroid Function Tests described as a measurement of the thyroxine binding globulin protein in a biological specimen.", + "output": "Assay of thyroid activity (Hormone measurement)" + }, + { + "input": "Definition: Genetic Diseases, X-Linked described as a rare genetic primary bone dysplasia with decreased bone density disorder with characteristics of childhood-onset osteoporosis associated with recurrent, multiple, osteoporotic, long bone fractures and/or vertebral compression fractures, significant height loss in adulthood, low bone mineral density scores and otherwise no other abnormalities. Heterozygote females may be unaffected or have a milder phenotype. There is evidence the disease can be caused by mutation in the PLS3 gene on chromosome Xq23.", + "output": "X-linked osteoporosis with fractures (Dysplasia with decreased bone density)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the least plentiful of all 22 amino acids and an essential amino acid in humans (provided by food), Tryptophan is found in most proteins and a precursor of serotonin. Tryptophan is converted to 5-hydroxy-tryptophan (5-HTP), converted in turn to serotonin, a neurotransmitter essential in regulating appetite, sleep, mood, and pain. Tryptophan is a natural sedative and present in dairy products, meats, brown rice, fish, and soybeans.", + "output": "Tryptophan product (Amino Acids)" + }, + { + "input": "Definition: Language described as collective term for a combination of tags and options, style sheets, and programming that allows users to create web pages in hypertext Mark-up language (HTML) that are more responsive to user interaction than previous versions of HTML.", + "output": "dynamic HTML (Hypertext Markup Language)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare chromosomal disorder in which the tip of the short arm (p arm) of chromosome 10 is deleted resulting in a variable phenotype depending on the size of the deletion. The deletion may involve only the terminal 10p15 band, or extend towards the centromere to bands 10p14 or 10p13. Around 50 cases of pure distal monosomy 10p have been reported. The phenotype remains unclear: low birth weight, persistent growth delay, mild psychomotor retardation and hypotonia have been reported, together with single reports of ventricular septal defect, hydrocephalus and hypogenitalia. Distal monosomy 10p generally occurs de novo or may be associated with a parental translocation.", + "output": "Distal 10p deletion (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the taxonomic order of mammals which include hares, rabbits and pikas.", + "output": "Order Lagomorpha (Eutheria)" + }, + { + "input": "Definition: amphetamine described as a kind of hallucinogenic drug", + "output": "MDA (Central Nervous System Stimulants)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the performance of cardiac catheterization with the intent of making a modification to the structures of the heart or surrounding vessels.", + "output": "Interventional Cardiac Catheterization (Cardiac Catheterization Procedures)" + }, + { + "input": "Definition: Mother described as a female parent in the parent-child relationship established by a legal adoption proceeding.", + "output": "Adoptive Mother (Adoptive parent)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the Roland Morris disability questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).", + "output": "CDISC Questionnaire RDQ Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Medical Devices described as a medical device placed on or inserted in an anatomic site for accurate visualization of a particular area, prior to radiation treatment or surgery. Examples include markers inserted in the prostate gland for visualization of the site affected by cancer, prior to radiation therapy; markers taped to the scalp prior to imaging in frameless stereotactic brain surgery; and femoral and tibial pins used for spatial orientation in total knee replacement.", + "output": "Fiducial Markers (Medical Devices)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the platelet clumps in a biological specimen.", + "output": "PLT Clumps (Laboratory Procedure)" + }, + { + "input": "Definition: Increased circulating IgG level described as an increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains.", + "output": "Polyclonal elevation of circulating IgG (Increased circulating IgG level)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+.", + "output": "CoA-disulfide reductase activity (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)" + }, + { + "input": "Definition: Demyelinating Diseases described as diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.", + "output": "Demyelinating Disorder (Neuromuscular Diseases)" + }, + { + "input": "Definition: something described as specializes in the prospective procurement, preservation and distribution of human tissues for research. Trained personnel coordinate the retrieval, preservation and delivery of specimens obtained from surgical resections and from autopsies.This resource provides normal, benign, pre-cancerous and cancerous human tissue to the scientific community for basic and developmental studies in many areas of cancer research.", + "output": "CHTN (Consortium or Network)" + }, + { + "input": "Definition: Mental Process described as specific mental functions related to the feeling and affective components of the processes of the mind.", + "output": "Emotional functions, unspecified (Emotional state observations)" + }, + { + "input": "Definition: something described as abuse or neglect of elderly persons in a family, institutional, or other setting.", + "output": "Senior Abuses (Victim of abuse finding)" + }, + { + "input": "Definition: Inflammatory disorder of lower respiratory tract described as a type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.", + "output": "pneumonia aspiration (Disease or Syndrome)" + }, + { + "input": "Definition: something described as stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space. N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. M0: No distant metastasis. M1: Distant metastasis.", + "output": "Stage IV Keratinizing Epidermoid Carcinoma of the Nasopharynx (Stage IV Nasopharyngeal Carcinoma AJCC v7)" + }, + { + "input": "Definition: Pharmacologic Substance described as a long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.", + "output": "Amlodipino (A [Preparations])" + }, + { + "input": "Definition: something described as the process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "output": "Bergmann glial cell differentiation (astrocyte differentiation)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child) In the past one month, how much of a problem has this been for your child: My child gets sores and/or rashes.", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child - Get Sores and/or Rashes (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)" + }, + { + "input": "Definition: Body Location or Region described as the most caudal and ventral of two or three parts of area 29 defined by Nissl stain in the rat ( Swanson-2004; Paxinos-2009b ) and mouse ( Franklin-2008 ). The other parts are zone b of the retrosplenial granular area and zone c of the retrosplenial granular area ( Paxinos-2009b ) or zone b-c of the retrosplenial granular area ( Swanson-2004 ).\\r\\n", + "output": "zone a of the retrosplenial granular area (Body Location or Region)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification.", + "output": "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification (negative regulation of multicellular organismal process)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transcriptional regulation and in vitamin D3 metabolism.", + "output": "VITAMIN D HORMONE RECEPTOR (Gene or Genome)" + }, + { + "input": "Definition: PSMB5 gene described as human PSMB5 wild-type allele is located in the vicinity of 14q11.2 and is approximately 19 kb in length. This allele, which encodes proteasome subunit beta type-5 protein, is involved in protein catabolism.", + "output": "LMPX (PSMB5 gene)" + }, + { + "input": "Definition: Quantitative Concept described as the percentage of people in a study or treatment group who are alive for a certain period of time after they were diagnosed with or treated for a disease, such as cancer. The survival rate is often stated as a five-year survival rate, which is the percentage of people in a study or treatment group who are alive five years after diagnosis or treatment.", + "output": "overall survival rate (Quantitative Concept)" + }, + { + "input": "Definition: something described as a question about whether a person would prefer not to hear a lot of details.", + "output": "Prefer Not to Hear a Lot of Details (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the formation of pancreatic juice and bile.", + "output": "SCT Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as perihilar bile duct cancer with tumor invading adjacent hepatic parenchyma.", + "output": "Hilar Cholangiocarcinoma pT2b TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated", + "output": "Grade 1 Acoustic nerve disorder NOS (Acoustic Nerve Disorder NOS, CTCAE)" + }, + { + "input": "Definition: something described as any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.", + "output": "positive regulation of inositol-polyphosphate 5-phosphatase activity (regulation of inositol-polyphosphate 5-phosphatase activity)" + }, + { + "input": "Definition: Skin, Human described as the pores are generally fine with a papery thin texture that feels dry to the touch. Usually flaky and dull looking.", + "output": "Anhydrotic skin (quality of skin symptoms)" + }, + { + "input": "Definition: Administrative Activity described as placing a patient in a room.", + "output": "Rooming (Administrative Activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2).", + "output": "ethylbenzene:(acceptor) oxidoreductase activity (oxidoreductase activity, acting on CH or CH2 groups)" + }, + { + "input": "Definition: Leukoviruses - Subgenus D described as causes mammary adenocarcinomas in mice of a certain genotype and is influenced by estrogenic stimulation; transmitted from mother to offspring via the milk.", + "output": "Mammary Cancer Virus (Retroviridae)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of ATP biosynthetic process.", + "output": "regulation of ATP anabolism (regulation of ATP metabolic process)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as terminology associated with the specimen condition codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "Specimen Condition (CDISC SDTM Terminology)" + }, + { + "input": "Definition: something described as a document that points out the location of people, places, or objects.", + "output": "Directory (Publication Formats)" + }, + { + "input": "Definition: something described as increased length of the uvula.", + "output": "Elongated uvula (Abnormality of the uvula)" + }, + { + "input": "Definition: Insecticides described as the organophosphorus agent dimethoate.", + "output": "phosphamide (Insecticides)" + }, + { + "input": "Definition: something described as a genus of long filamentous gram-negative anaerobic rod bacteria in the Fusobacteriaceae family; sometimes associated with oral or urogenital infections.", + "output": "207 LEPTOTRICHIA (unclassified Leptotrichia)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Enterobacter cloacae.", + "output": "Bacillus cloacae (Enterobacteriaceae)" + }, + { + "input": "Definition: Exercisers, Muscle Strength, Pneumatic, Upper Limb/Trunk described as muscle strength exercisers designed to provide resistance to muscular contraction using a pneumatic mechanism when the user performs pull down exercises of the trunk and upper limb muscles. These exercisers usually consist of a stand-alone machine with a pneumatic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars on which the user exerts force to counteract the exerciser resistance. Typically users grasp the lever bar and pull it down toward their chest. Pulldown strength exercisers are intended to improve strength in the back (latissimus dorsi), chest, and arm muscles; increase muscle size; enhance muscle endurance; and improve power and bone density.", + "output": "Exercisers, Muscle Strength, Pneumatic, Upper Limb/Trunk, Pulldown (Manufactured Object)" + }, + { + "input": "Definition: Retinoblastoma cT3 TNM Finding v8 described as phthisis or pre-phthisis bulbi.", + "output": "Retinoblastoma cT3a TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Finding described as the reemergence of a disorder as diagnosed by clinical and/or laboratory evidence following four documented periods of remission.", + "output": "Fourth Relapse (Subsequent Relapse)" + }, + { + "input": "Definition: something described as a prominence on the sphenoid bone, which separates the sella turcica from the chiasmatic sulcus.", + "output": "Tuberculum sellae (Skeletal System Part)" + }, + { + "input": "Definition: something described as a federally-funded non-profit organization that acts as a liaison between tissue and organ donors and the scientific community.", + "output": "National Disease Research Interchange (Professional or Occupational Group)" + }, + { + "input": "Definition: Dispensers, Medication, Pill, Unit-Dose described as unit dose medication pill dispensers designed to store and deliver controlled narcotics in the correct single dose needed for an individual patient. These dispensers usually consist of a container with medication compartments to store each unit-dose of pills. Narcotic control unit-dose dispensers may be manually operated including a tamper-proof security slide or power operated managing access, control and tracking of unit-dose controlled substances. They are commonly used in healthcare facilities.", + "output": "Dispensers, Medication, Pill, Unit-Dose, Narcotic Control (Medical Device)" + }, + { + "input": "Definition: something described as a domain utilized for the submission of biospecimen records related to persons associated with the study subject.", + "output": "Associated Persons Biospecimen (Intellectual Product)" + }, + { + "input": "Definition: Family Member Health Status described as evidence that the victim is no longer hurt or exploited", + "output": "Abuse Cessation (Family Member Health Status)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as an area of cerebral cortex defined on the basis of multiple criteria including function and connectivity. In the human it has been defined by meta-analysis of data from studies involving noninvasive measures of neural activation associated with interoceptive sensations, such as visceral sensations, hunger, thirst, sexual arousal, change in body temperature, listening to one's own heart beat, and resisting the urge to void. A study of the insula showed primary activation of the central part of the structure ( Kurth-2010b ). If the internal structure of the central part of the human insula is comparable to that of the macaque, it is predominantly dysgranular insular cortex (Roberts) ( Mesulam-1984 ) with some involvement of agranular insular cortex (Roberts) ( Paxinos-2009a ). Most authors regard the topological equivalent of the visceral cortex of the rat ( Swanson-2004 ) and the mouse ( Hof-2000 ) to be granular insula.", + "output": "visceral cortex (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a triplet codon-amino acid adaptor activity that recognizes a GAU codon.", + "output": "GAU codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: something described as systemic lupus erythematosus nephritis that appears normal under light microscopy, but with evidence of immune deposits by immunofluorescence. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.)", + "output": "Minimal Mesangial Lupus Nephritis (Lupus Nephritis)" + }, + { + "input": "Definition: Imaging Device described as imaging Phantoms are used for the assessment of image quality. Within these functional categories phantoms can be further defined. (1) Body Phantoms: have the shape and composition of the human body or part of it. They are also referred to as anthropomorphic phantoms. (2) Phantoms that are used for standardization and inter-comparison of various radiation conditions are often referred to as Standards. (3) Reference Phantoms include phantoms used to derive radiation dose calculations, mineral density equivalences or other similar type measurements. They can further be defined by their intended modality such as Ultrasound, Mammography, Computed Tomography (CT), etc.", + "output": "Phantoms, Imaging (Radiographic unit)" + }, + { + "input": "Definition: Hereditary Connective Tissue Disorder described as a rare genetic disease with characteristics of hypertelorism with facial features that can closely resemble craniofrontonasal dysplasia, such as prominent forehead, widow's peak, heavy and broad eyebrows, long palpebral fissures, ptosis, high and broad nasal bridge, short nose, low-set ears, natal teeth, thin upper lip and a grooved chin. Limb features include fifth-finger clinodactyly, pes adductus, mild interdigital webbing. Urogenital features include bilateral cryptorchidism and shawl scrotum in males. Other manifestations include umbilical hernia/omphalocele and cardiac defects. Psychomotor development is normal.", + "output": "Teebi syndrome (Sphenoidal dysostosis)" + }, + { + "input": "Definition: Idea or Concept described as a role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.", + "output": "Disease Has Normal Tissue Origin (NCI Thesaurus Role)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter C described as any elsewhere undefined Oriental herb and natural substance, letter C, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "ltr C undef.Orntl hrb&ntrl s (Classification)" + }, + { + "input": "Definition: DNA metabolic process described as the chemical reactions and pathways involving plastid DNA.", + "output": "plastid DNA metabolic process (Genetic Function)" + }, + { + "input": "Definition: acetate described as a synthetic carboxylic acid with antibacterial and antifungal properties. Although its mechanism of action is not fully known, undissociated acetic acid may enhance lipid solubility allowing increased fatty acid accumulation on the cell membrane or in other cell wall structures. Acetic acid, as a weak acid, can inhibit carbohydrate metabolism resulting in subsequent death of the organism.", + "output": "ACETIC ACID,GLACIAL (A [Preparations])" + }, + { + "input": "Definition: Finding described as patients with cardiac disease resulting in marked limitation of physical activity. They are comfortable at rest. Less than ordinary activity causes fatigue, palpitation, dyspnea, or anginal pain.", + "output": "Angina with mild exertion (Finding)" + }, + { + "input": "Definition: Medical Device described as electric saws designed to cut tissue during autopsy and dissection (i.e., postmortem) procedures using a serrated blade that rotates at a very high speed. These saws are waterproof (doubled-insulated), heavy-duty, handheld instruments with an electric motor; a mechanism to drive the blade; a detachable, toothed, circular flat blade; and an electric cable. Saws using a mechanism that operates two parallel rotating blades are also available. Rotary electric postmortem saws are used to cut tissue and/or bones not intended for subsequent examination or test; saws are frequently provided with an extraction unit and a container for collecting bone/tissue debris.", + "output": "Saws, Postmortem, Electric, Rotary (Medical Device)" + }, + { + "input": "Definition: something described as the presence of multiple serrated polyps in the colon. The polyps are predominantly sessile serrated adenomas/polyps. A minority of the polyps are microvesicular variants of hyperplastic polyps. According to some authors, the polyps are proximal to the sigmoid colon. According to others, the polyps are distributed throughout the entire colon.", + "output": "Colon Serrated Polyposis (Disease or Syndrome)" + }, + { + "input": "Definition: Pharmacologic Substance described as abrotanum, southernwood, old man.", + "output": "Artemisia abrotanum (Homeopathic remedies letter A)" + }, + { + "input": "Definition: Measurement Unit Description described as days times picograms per milliliter (area under the curve), divided by milligrams per gram (dose normalized by body weight).", + "output": "d.pg/ml/(mg/g) (Quantitative Concept)" + }, + { + "input": "Definition: Diagnostic procedure on female genital system described as providing an analysis of a female client/patient's cervical smear to detect viral infection and/or assess her estrogen and progesterone levels. Service is billed per test.", + "output": "Cervical smear (histological diagnosis)" + }, + { + "input": "Definition: something described as a hematocrit measuring device is a system consisting of instruments, tubes, racks, and a sealer and a holder. The device is used to measure the packed red cell volume in blood to determine whether the patient's total red cell volume is normal or abnormal. Abnormal states include anemia (an abnormally low total red cell volume) and erythrocytosis (an abnormally high total red cell mass). The packed red cell volume is produced by centrifuging a given volume of blood.", + "output": "hematocrit centrifuge (Medical Device)" + }, + { + "input": "Definition: kinase activity described as catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate.", + "output": "phosphatidylinositol monophosphate kinase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: Cancer Vaccines described as an individualized peptide-based cancer vaccine comprised of three to five human leukocyte antigen (HLA) binding tumor-specific peptides obtained from the autologous mutated proteins from the tumor cells of patients with acute lymphoblastic leukemia (ALL), with potential immunomodulating and antineoplastic activity. Upon intradermal administration of the personalized multi-HLA-binding peptide vaccine, the peptides may induce a tumor-specific cytotoxic T-lymphocyte (CTL) response against the peptides that are expressed by the tumor cells.", + "output": "Personalized Multi-HLA-binding Peptide Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: Skin and Subcutaneous Tissue Disorders, CTCAE described as a disorder characterized by a change in the color of the nail plate.", + "output": "Nail Discoloration, CTCAE (Skin and Subcutaneous Tissue Disorders, CTCAE)" + }, + { + "input": "Definition: something described as a benzothiadiazine-sulfonamide derivative belonging to the class of the thiazide diuretics.", + "output": "Product containing methyclothiazide (Saluretic agent)" + }, + { + "input": "Definition: Antithrombin Proteins described as a plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.", + "output": "Antithrombin III-containing product (Proteins)" + }, + { + "input": "Definition: adhesion receptor-mediated virion attachment to host cell described as process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection.", + "output": "reversible bacteriophage attachment, binding of host cell surface receptor (adhesion receptor-mediated virion attachment to host cell)" + }, + { + "input": "Definition: something described as the removal of the ubiquitin group from a monoubiquitinated histone protein.", + "output": "monoubiquitinated histone deubiquitinylation (Molecular Function)" + }, + { + "input": "Definition: something described as a variable domain fragment from the ancestral IMMUNOGLOBULIN (termed 'novel antigen receptor' or IG-NAR) of cartilaginous fish such as SHARKS.", + "output": "VNAR Immunoglobulin Fragments (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Oils, Volatile described as lemongrass.", + "output": "Cymbopogon citratus (DC.) Stapf (Plant)" + }, + { + "input": "Definition: negative regulation of transcription, DNA-templated described as any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.", + "output": "negative regulation of DNA-dependent transcription, elongation (regulation of DNA-templated transcription, elongation)" + }, + { + "input": "Definition: Enterococcus described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is catalase negative, requires folic acid for growth in culture, ferments arabinose and melibiose, does not ferment citrate, does not reduce tetrazolium and is a lactic acid bacteria. E. faecium is a leading agent of nosocomial infections in humans.", + "output": "Streptococcus faecium (Enterococcus, group II)" + }, + { + "input": "Definition: Connective Tissue Cells described as a cell arising from mesenchymal stem cells that produces and is surrounded by the extracellular matrix of cartilage.", + "output": "Cartilage cell, NOS (Connective Tissue Cells)" + }, + { + "input": "Definition: Finding described as philadelphia chromosome abnormality; t(9;22)(q34;q11) was not found; bcr/abl gene rearrangement was not tested; therefore it is not known if present or not.", + "output": "Ph-/BCR Unknown (Genetic finding)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of a solvent containing no active substances, intended for use in the preparation of a solution for infusion.", + "output": "Solvent for solution for infusion (Biomedical or Dental Material)" + }, + { + "input": "Definition: multi-organism reproductive process described as the process of giving birth to one or more offspring.", + "output": "childbirth (LABOR AND PARTURITION)" + }, + { + "input": "Definition: Radionuclide Imaging described as radionuclide imaging of the liver, gallbladder, and bile ducts using the radioactive tracer 99mTc-hepatic iminodiacetic acid.", + "output": "cholescintigraphy (Radionuclide Imaging)" + }, + { + "input": "Definition: Sperm Motility described as any process involved in the controlled movement of a flagellated sperm cell.", + "output": "flagellated sperm movement (Sperm Motility)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measurement of a plane or solid angle.", + "output": "Unit of Angle (Quantitative Concept)" + }, + { + "input": "Definition: Multisystem disorder C-D described as a combination of symptoms caused by the release of serotonin and other substances from carcinoid tumors of the gastrointestinal tract. Symptoms may include flushing of the face, flat angiomas (small collections of dilated blood vessels) of the skin, diarrhea, bronchial spasms, rapid pulse, and sudden drops in blood pressure.", + "output": "secretion; carcinoid tumor, hormone (Malignant Carcinoid Syndrome)" + }, + { + "input": "Definition: Amino Acid Sequence described as the (EXternal proTEIN) sequences flanking INTEINS, which are internal fragments of precursor proteins removed by PROTEIN SPLICING. Concomitantly, as the inteins are excised, the exteins are ligated to form mature proteins.", + "output": "Exteins (Amino Acid Sequence)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the Clostridium tetani toxin antibody in a biological specimen.", + "output": "Clostridium tetani Toxin Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: Immunologic Factor described as a recombinant form of the monoclonal IgM antibody M12 isolated from a Waldenstrom macroglobulinaemia patient (rHIgM12) with potential immunomodulating activity. B7-DC cross-linking antibody rHIgM12B7 binds and crosslinks the B7 co-stimulatory family member B7-DC (PD-L2) on dendritic cells (DCs), antigen presenting cells (APCs) that play a crucial role in the human immune response. This results in enhanced activation of DCs; enhanced antigen-presenting activity; and increased production of immunomodulatory cytokines (especially interleukin 12); and may potentiate a specific cytotoxic T lymphocyte (CTL) response against Waldenstrom macroglobulinaemia B cells.", + "output": "rHIgM12B7 (Immunologic Factor)" + }, + { + "input": "Definition: something described as a unique symbol that establishes the identity of the processed product.", + "output": "ProcessedProduct.identifier (Intellectual Product)" + }, + { + "input": "Definition: Positive Laboratory Test Result described as an indication that hepatitis C RNA has been detected in a sample.", + "output": "Hepatitis C Virus RNA Positive (Positive Laboratory Test Result)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as iron ion requiring two electrons to return to its elemental state.", + "output": "Iron(2+) (Dietary Iron)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the sodium-dependent phosphate transport protein 2B (NaPi2b), and covalently linked to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of DNIB0600A binds to NaPi2b-expressing tumor cells and is internalized, thereby delivering MMAE intracellularly. Proteolytic cleavage releases MMAE, which then binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. NaPi2b, a tumor-associated antigen (TAA), overexpressed in a variety of cancer cell types, plays a key role in transport of inorganic phosphate and the maintenance of phosphate homeostasis.", + "output": "Lifastuzumab Vedotin (Immunologic Factor)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "output": "medulla oblongata development (Organ or Tissue Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a thyroid autoantibody immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the thyroid autoantibodies (antibodies produced against the body's own tissues). Measurement of thyroid autoantibodies may aid in the diagnosis of certain thyroid disorders, such as Hashimoto's disease (chronic lymphocytic thyroiditis), nontoxic goiter (enlargement of thyroid gland), Grave's disease (enlargement of the thyroid gland with protrusion of the eyeballs), and cancer of the thyroid.", + "output": "SYSTEM, TEST, THYROID AUTOANTIBODY (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a rare genetic syndromic intellectual disability disorder characterised by moderate to severe intellectual disability and esotropia. Other associated features may include growth failure (underweight, failure to thrive, short stature), microcephaly, tone abnormalities (hypotonia, spasticity), epilepsy, behavioural problems (hyperactivity, aggressiveness), and/or abnormal brain morphology, including arachnoid cyst, cerebral atrophy, mild ventriculomegaly, and abnormal central nervous system myelination or corpus callosum agenesis. There is evidence the disease is caused by homozygous mutation in the ADAT3 gene on chromosome 19p13.", + "output": "Intellectual disability with strabismus syndrome (Esotropia)" + }, + { + "input": "Definition: something described as percutaneous stricturoplasty biliary catheters that include a balloon that can be inflated with air, water or contrast media at or near their distal tip. The procedure is generally started with a small-caliber balloon (e.g., 4 to 6 mm in diameter) and progresses up to an 8 to 12 mm ballon, depending on the bile duct diameter. These catheters are mostly used for dilation of benign strictures of the biliary tree; their use is frequently followed by placing of stents.", + "output": "Catheters, Biliary, Stricturoplasty, Percutaneous, Balloon (Catheters, Biliary, Stricturoplasty, Percutaneous)" + }, + { + "input": "Definition: Finding described as an abnormality in perception of contrast as measured by the Vistech wall chart sine wave grating test.", + "output": "Abnormal Vistech contrast sensitivity test (Abnormal contrast sensitivity)" + }, + { + "input": "Definition: Geographic Area described as the planned country within which the investigation, trial or study is taking place.", + "output": "Planned Country of Investigational Sites (Geographic Locations)" + }, + { + "input": "Definition: regulation of intracellular sterol transport described as any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells.", + "output": "regulation of intracellular cholesterol transport (Cell Function)" + }, + { + "input": "Definition: Cardiovascular neoplasms malignant and unspecified described as a teratoma within the heart. Most commonly, these tumors are detected in the pericardial cavity attached to the pulmonary artery and aorta. The tumour size within the heart varies from 2 to 9 cm in diameter, and intrapericardial tumors as large as 15 cm have been reported. Intracardiac tumors arise from the atrial or ventricular wall as nodular masses protruding into the cardiac chambers. Cardiac and pericardial teratomas are easily detected in the fetus and neonate by two-dimensional echocardiography as heterogeneous and encapsulated cystic masses. Histologically, cardiac teratomas contain multiple immature elements including epithelium, neuroglial tissue, thyroid, pancreas, smooth and skeletal muscle, cartilage and bone.", + "output": "Cardiac teratoma (Cardiac neoplasms NEC)" + }, + { + "input": "Definition: Glucuronidase Inhibitor described as the orally bioavailable calcium salt of glucaric acid, a natural substance found in many fruits and vegetables, with potential chemopreventive activity. After absorption, glucaric acid is converted to d-glucaro-1,4-lactone which inhibits beta-glucuronidase, an enzyme found in certain bacteria that reside in the human gut. The detoxification of various toxin and sex hormone metabolites depends upon their conjugation to glucuronic acid in the liver and subsequent excretion of glucuronic acid conjugated metabolites in the bile. Bacterial beta-glucuronidase may catalyze the deconjugation of glucuronic acid conjugated metabolites of toxins and sex hormones, thus prolonging exposure to unconjugated and unexcreted toxin and sex hormone metabolites. Accordingly, calcium glucarate supplementation may indirectly inhibit sex hormone-mediated and toxin-mediated tumorigenesis by inhibiting bacterial beta-glucuronidase activity. Elevated bacterial beta-glucuronidase activity may be associated with an increased risk for sex hormone-mediated and toxin-mediated cancers such as breast, prostate, and colon cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C335\" active clinical trials using this agent.", + "output": "2,3,4,5-tetrahydroxy-1,6- dioxido-hexane-1,6-dione, Calcium (Glucuronidase Inhibitor)" + }, + { + "input": "Definition: Receptor status described as an indication that EGFR expression has been detected in a sample.", + "output": "EGFR Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+).", + "output": "hydroxyglutarate synthase activity (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)" + }, + { + "input": "Definition: Overseas Departments of France described as a French overseas department on the northeast coast of South America. Its capital is Cayenne. It was first settled by the French in 1604. Early development was hindered because of the presence of a penal colony. The name of the country and the capital are variants of Guyana, possibly from the native Indian Guarani guai (born) + ana (kin), implying a united and interrelated race of people.", + "output": "French Guiana (Geographic Area)" + }, + { + "input": "Definition: General Qualifier described as this term applies to a family member who is diagnosed with the same condition as the individual who is the primary focus of investigation (the proband). []", + "output": "Affected (General adjectival modifier)" + }, + { + "input": "Definition: Crotalinae described as a genus of snakes of the subfamily Crotalinae, having a hollowed out pit in the maxillary bone between the eye and nostril. Most of the recognized species are found in the southwestern United States and northern Mexico. Several species are found as far north as Canada and east of the Mississippi, including southern Appalachia. They are named for the jointed rattle (Greek krotalon) at the tip of their tail. (Goin, Goin, and Zug: Introduction to Herpetology, 3d ed; Moore: Poisonous Snakes of the World, 1980, p335).", + "output": "Rattlesnakes (Chordata)" + }, + { + "input": "Definition: something described as catalysis of the transfer of an acyl group from one position to another within a single molecule.", + "output": "intramolecular transferase activity, transferring acyl groups (intramolecular transferase activity)" + }, + { + "input": "Definition: Potency Unit described as a dosing measurement based on the capful unit.", + "output": "Capful Dosing Unit (Quantitative Concept)" + }, + { + "input": "Definition: something described as a response indicating that something is or was not difficult.", + "output": "Not Difficult (Finding)" + }, + { + "input": "Definition: something described as money available in the public sector, including the local, city, county, state and federal government.", + "output": "Public Funds (Funding Source for Product)" + }, + { + "input": "Definition: Anatomical Abnormality described as uneven radiographic opacity of the epiphysis of the distal phalanx of the thumb.", + "output": "Irregular end part of thumb outermost bone (Irregular thumb epiphysis)" + }, + { + "input": "Definition: Non-Neoplastic Paranasal Sinus Disorder described as inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.", + "output": "sinus; inflammation (Inflammatory disorder of the respiratory tract)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.", + "output": "1-phosphatidylinositol binding (phosphatidylinositol binding)" + }, + { + "input": "Definition: Disease or Syndrome described as split-hand/foot malformation mapped to chromosome 10q24.", + "output": "CHROMOSOME 10q24 DUPLICATION SYNDROME (Split-Hand/Foot Malformation)" + }, + { + "input": "Definition: Traditional Chinese Medicine Formulation described as a traditional Chinese medicine (TCM)-based formulation that may benefit Qi, and boost Yin.", + "output": "Yi Qi Yang Yin Fang (Traditional Chinese Medicine Formulation)" + }, + { + "input": "Definition: something described as stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension. T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension. T2b: Tumor with parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Cervical carcinoma stage II AJCC v7 (Cervical Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: RECTUM AND ANUS: EXCISIONS described as a therapeutic surgical procedure in which the anus, rectum, part of the sigmoid colon, and the regional lymph nodes are removed through abdominal and perineal incisions.", + "output": "Abdominal Perineal Resection (Operations by approach)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.", + "output": "Colorectal Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Diffusion Magnetic Resonance Imaging described as a high angular resolution diffusion MRI technique that maps complex tissue structures at the scale of single MRI voxels.", + "output": "Diffusion Spectrum Imaging (Diffusion Magnetic Resonance Imaging)" + }, + { + "input": "Definition: Appendiceal Carcinoma pT4 TNM Finding v7 described as appendiceal carcinoma with tumor directly invading other organs or structures.", + "output": "Appendiceal Carcinoma pT4b TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Abnormal degeneration described as vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.", + "output": "proliferative vitreoretinopathy (Soft tissue lesion)" + }, + { + "input": "Definition: Tipravirus described as species in the genus OKAVIRUS, found in prawns off Australia.", + "output": "Gill-associated viruses (Tipravirus)" + }, + { + "input": "Definition: Neoplastic Processes described as a morphologic finding indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample.", + "output": "anaplasia (Neoplastic Processes)" + }, + { + "input": "Definition: Mammal described as anterior pituitary tumors nearly 100% in females over 18 months of age, pheochromocytomas or preneoplastic nodules in adrenal medulla about 40% in males, granulocytic leukemia 14% in animals over 18 months of age. Rarely show hyperplastic cortical nodules or adrenal cortical adenomas. High incidence of severe chronic nephritis. (Snell 1967). High 10-week body weight in males (19/23), and high relative heart weight in 10-week old males (19/23) (Tanase et al 1982).", + "output": "WN (Common Rattus Norvegicus Strains)" + }, + { + "input": "Definition: GCS NINDS Version Clinical Classification Question described as glasgow Coma Scale-NINDS Version (GCS NINDS Version) Best eye response.", + "output": "GCS01-Best Eye Response (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as hepatitis A virus cellular receptor 1 (359 aa, ~39 kDa) is encoded by the human HAVCR1 gene. This protein is involved in the modulation of asthma and allergic reactions.", + "output": "HAVcr-1 (Immunologic Factor)" + }, + { + "input": "Definition: something described as the determination of the amount of classic neutrophil cytoplasmic antibody present in a sample.", + "output": "ANCCLSAB (Laboratory Procedure)" + }, + { + "input": "Definition: Experimental Organism Neoplasm described as a benign neoplasm that arises from the mesenchymal and epithelial components and contains two or more cell types.", + "output": "EPITHELIAL-STROMAL TUMOR, BENIGN (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity.", + "output": "insulin receptor activity (protein-hormone receptor activity)" + }, + { + "input": "Definition: something described as a question about how an individual would rate their overall sleep quality.", + "output": "Overall Sleep Quality Rating (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as inflammation of the mucous membranes lining the gastrointestinal tract.", + "output": "Gastrointestinal mucositis (Inflammatory disease of mucous membrane)" + }, + { + "input": "Definition: something described as the identification and quantification of oxidized polyunsaturated fatty acids (oxylipins) in a biospecimen. In humans, the oxidized products are usually eicosanoids and the enzymes that produce specific eicosanoids are well characterized. Therefore, the oxylipin profile can indirectly identify the fatty acid oxidizing enzymes that are active in the sample.", + "output": "Oxylipin Metabolomic Profile (Metabolic marker)" + }, + { + "input": "Definition: something described as reduction of particle size to a coarse or fine dry powder by applying mechanical force involving grinding, attrition, or impact, where screening may be integral to size reduction; usually performed to de-agglomerate purified powders without changing the crystal size.", + "output": "Size Reduction Particle Sizing (Particle Size)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(8;13)(p11;q12) which fuses exon 17 of the ZMYM2 gene to exon 9 of the FGFR1 gene. This rearrangement is associated with 8p11 myeloproliferative syndrome.", + "output": "FGFR1/ZMYM2 Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: cellular aromatic compound metabolic process described as the chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.", + "output": "isoquinoline alkaloid metabolic process (organic cyclic compound metabolic process)" + }, + { + "input": "Definition: something described as airborne radioactive particles that fall to the ground during and after an atomic bombing, nuclear weapons test, or nuclear plant accident.", + "output": "Fallout, Radioactive (Radiologic Health)" + }, + { + "input": "Definition: something described as a relationship between a planned criterion group and an option that can satisfy it, either a planned activity, a planned observation result or another planned criterion group, i.e. a relationship between a logical set of parenthesis and one of the options inside the parentheses.", + "output": "Planned Criterion Group Option Relationship (Relationships)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a dosage form designed to release active and/or inert ingredient(s) slowly so as to achieve a constant circulating concentration of the ingredient over a period of time.", + "output": "Sustained Release Dosage Form (Modified Release Dosage Form)" + }, + { + "input": "Definition: Phytotoxin described as a chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.", + "output": "(E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide (Alkylamide)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 9 on a scale that ranges from 0: Health problems had no effect on my daily activities to 10: Health problems completely prevented me from doing my daily activities.", + "output": "Health Problems Effect on Daily Activities Score 9 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Therapeutic heat application described as abnormally high temperature intentionally induced in tumors or cancerous regions; most often induced by radiation (heat waves, infrared), ultrasound, or drugs.", + "output": "neoplasm/cancer thermotherapy (neoplasm/cancer therapy)" + }, + { + "input": "Definition: Cell Component described as an SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae.", + "output": "SCF-Skp2 ubiquitin ligase complex (SCF ubiquitin ligase complex)" + }, + { + "input": "Definition: Infection by Ascomycetes described as a fungal infection caused by Coccidioides immitis. Affected individuals usually have mild flu-like symptoms. However, pneumonia and systemic involvement with the formation of abscesses may develop as complications of the disease.", + "output": "POSADAS-WERNICKE DISEASE (Korean Standard Classification of Disease Version 5)" + }, + { + "input": "Definition: Basal transcription factor genes described as for transcription initiation, the nonphosphorylated RNA polymerase II is recruited by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ to form a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation and TFIIH contains a kinase activity for phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD. A 52-kD subunit has also been identified as a component of the TFIIH core, along with p89, p62, p44, and p34.", + "output": "TFIIH Subunit Gene (Gene or Genome)" + }, + { + "input": "Definition: Critical Care Nursing discipline described as nursing care of the surgical patient before, during, and after surgery.", + "output": "NURS PERIOP (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: SIQ-JR Questionnaire Question described as suicidal Ideation Questionnaire-Junior (SIQ-JR) Specific standardization %: Sample 1.", + "output": "SIQ02-Specific %: Standard Sample 1 (Intellectual Product)" + }, + { + "input": "Definition: Electromechanical Devices described as electromechanical surgical units designed for electrically powered mechanical ablation (resection) of abnormal soft tissue (i.e., tumors) in the central nervous system. This equipment typically consist of (1) a central unit (a console) that provides power and may also provide suction to a cutting handpiece that includes controls (e.g., to choose from cutting and/or aspiration mode), (2) a detachable cutting handpiece, and (3) a switch, that may consist of a foot switch and control pedal. The central unit also provides appropriate connections to the electric power supply, handpiece, aspiration line, and disposable material canister. Neurologic electromechanical surgical units are mostly intended for cutting and disposing intracranial (i.e., brain) and/or spinal soft tissue tumors during minimally invasive surgical procedures (e.g., image guided stereotactic surgery) or open surgery procedures.", + "output": "Electromechanical Surgical Units, Neurology (Medical Device)" + }, + { + "input": "Definition: something described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 1, Word 1.", + "output": "AVL01-List A Recall 1 Word 1 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: New client in-office with nursing diagnosis described as assessing and/or managing a new client using nursing diagnoses in a comprehensive, prolonged, 120-minute, in-office meeting. Use this code to describe advanced nursing care without physician oversight. The client may or may not have a medical diagnosis.", + "output": "nrse new inofc 120min (Health Care Activity)" + }, + { + "input": "Definition: something described as the term describes the situation in which a constant drug dose elicits increasing effects. The condition is opposite to drug tolerance since less dose of the substance is required to reinstate the initial effect (reverse-tolerance). The concept does not refer to cumulative drug effect.", + "output": "Sensitization drug (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with interleukin-33.", + "output": "IL-33 binding (Molecular Function)" + }, + { + "input": "Definition: something described as a dose-dense chemotherapy regimen consisting of methotrexate, vinblastine, doxorubicin, cisplatin (DDMVAC) and the addition of a selected growth factor to support the (neo)adjuvant treatment of bladder cancer.", + "output": "DDMVAC-GF (Regimen Used to Treat Bladder Carcinoma)" + }, + { + "input": "Definition: Dermal and epidermal conditions NEC described as the presence of multiple xanthomas (xanthomata) in the skin. Xanthomas are yellowish, firm, lipid-laden nodules in the skin.", + "output": "Xanthomatosis, NOS (Lipid Metabolism Disorders)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - During deployment: I could count on my family members or friends at home for good advice.", + "output": "DRRI-2 - I: Could Count on Family Advice (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: something described as a transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.", + "output": "regulation of transcription from RNA polymerase II promoter by carbon catabolites (Genetic Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a recently described syndrome associated with variable developmental delay, facial dysmorphism, seizures and autistic spectrum disorder. This syndrome is caused by an interstitial deletion encompassing 16q24.3. They vary in size the common region of overlap is only 90 kb and comprises two candidates genes, ANKRD11 (Ankyrin Repeat Domain 11) and ZNF778 (Zinc Finger 778).", + "output": "Monosomy 16q24.3 (16q partial monosomy syndrome)" + }, + { + "input": "Definition: something described as a type of anticancer drug.", + "output": "Derivative, Anthraquinone (anthracene)" + }, + { + "input": "Definition: Genes, Homeobox described as this gene is involved in the regulation of genes associated with pituitary development.", + "output": "pituitary transcript factor 1 (Genes, Homeobox)" + }, + { + "input": "Definition: Biological Response Modifiers described as a mouth rinse containing 0.25% East Indian sandalwood oil, which is derived from the heartwood of Santalum album, a tree native to southern Asia, with potential anti-inflammatory, anti-infective and anti-mucositis activities. East Indian sandalwood oil (EISO) is primarily comprised of the sesquiterpene alcohols alpha- and beta-santalol. Although the exact mechanisms of action through which EISO exerts its effects have yet to be fully elucidated, upon rinsing the oral cavity with the EISO mouth rinse, the active ingredients in the oil may inhibit the production of pro-inflammatory cytokines and chemokines, most likely through the inhibition of the activity of key inflammatory enzymes, including the cyclooxygenases. This prevents inflammation of the mucosal membranes and may prevent or decrease chemotherapy- and/or radiation-induced oral mucositis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121509\" active clinical trials using this agent.", + "output": "East Indian Sandalwood Oil Mouth Rinse (Biological Response Modifiers)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare ectodermal dysplasia syndrome with characteristics of dysplastic abnormalities of the hair and teeth (including hypodontia, abnormally shaped teeth, scalp hypotrichosis and pili annulati), follicular hyperkeratosis on the trunk and limbs, and hyperopia. Intensified delineation, reticular hyperpigmentation of the nape and astigmatism have also been reported. There have been no further descriptions in the literature since 1985.", + "output": "Pilodental dysplasia with refractive errors (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: modified amino acid transport described as the directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "S-methylmethionine transport (modified amino acid transport)" + }, + { + "input": "Definition: Membrane Glycoproteins described as large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.", + "output": "Antigen, I-A (Immunologic Factor)" + }, + { + "input": "Definition: Classification described as potentially cancer-causing compound containing carbon and hydrogen in the form of an unsaturated, usually hexagonal, ring structure with one or more nitro-group(s), -NO2, attached to one or more aromatic ring(s). The compounds can be single ring, or double, triple, or multiple fused rings. These compounds are normally found in particulate emissions from many combustion sources, like diesel exhaust.", + "output": "Nitroarene Carcinogen (Classification)" + }, + { + "input": "Definition: zinc supplement described as a salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1280\" active clinical trials using this agent.", + "output": "zinc sulphate (Zinc Supplements)" + }, + { + "input": "Definition: Surgical Drapes described as patient surgical drapes intended for multiple uses to provide a barrier between the unsterile skin of the patient and the sterile surgical field. These patient surgical drapes provide liquid-proof protection while allowing sweat to escape, promoting increased comfort for patients. Reusable patient surgical drapes are used once and then disinfected; they are available in many materials such as cotton, polyester, or a blend of both.", + "output": "Surgical Drapes, Patient, Reusable (Medical Device)" + }, + { + "input": "Definition: Biologically Active Substance described as short transient receptor potential channel 4-associated protein (797 aa, ~91 kDa) is encoded by the human TRPC4AP gene. This protein may play a role in both ion channel-dependent transport and protein ubiquitination.", + "output": "Trp4-Associated Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Agenesis of permanent molar described as agenesis of either maxillary first permanent molar or mandibular first permanent molar or both.", + "output": "Agenesis of six year molar (Anatomical Abnormality)" + }, + { + "input": "Definition: Fifth cranial nerve finding described as diseases of the trigeminal nerve or its nuclei, which are located in the pons and medulla. The nerve is composed of three divisions: ophthalmic, maxillary, and mandibular, which provide sensory innervation to structures of the face, sinuses, and portions of the cranial vault. The mandibular nerve also innervates muscles of mastication. Clinical features include loss of facial and intra-oral sensation and weakness of jaw closure. Common conditions affecting the nerve include brain stem ischemia, INFRATENTORIAL NEOPLASMS, and TRIGEMINAL NEURALGIA.", + "output": "Trigeminal nerve disorder, NOS (Facial Neuralgia)" + }, + { + "input": "Definition: Macrocephaly described as a rare syndrome with features of multiple congenital anomalies with macrocephaly (of post-natal onset), large anterior fontanelle, progressive complex spastic paraplegia, coarse facial features (broad and high forehead, deeply set eyes, short philtrum with thin upper lip, large mouth and prominent incisors), seizures, and intellectual deficit of varying severity. Inheritance appears to be autosomal recessive.", + "output": "MACROCEPHALY WITH SPASTIC PARAPLEGIA AND DISTINCTIVE CRANIOFACIAL APPEARANCE (Multiple malformation syndrome with facial defects as major feature)" + }, + { + "input": "Definition: Poaceae described as formerly known as Rhynchelytrum repens, a member of the perennial grass family native to South Africa, widely distributed and known by different common names. It is used as a diabetes cure in folk medicine and actively studied for its hypoglycemic properties.", + "output": "Melinis repen (Plant)" + }, + { + "input": "Definition: something described as air pollutants which affect environmental conditions.", + "output": "AIR POLLUTANTS ENVIR (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as a superordinate descriptor for one or more Medical Dictionary for Regulatory Activities (MedDRA) preferred terms (PTs) for the adverse event.", + "output": "Adverse Event MedDRA High Level Term (Intellectual Product)" + }, + { + "input": "Definition: Regimen Used to Treat Hodgkin Lymphoma described as a chemotherapy regimen consisting of mechlorethamine, vincristine, vinblastine, procarbazine, and prednisone that may be used in the treatment of advanced Hodgkin lymphoma (HL).", + "output": "Mechlorethamine/Vincristine/Vinblastine/Procarbazine/Prednisone (Regimen Used to Treat Hodgkin Lymphoma)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.", + "output": "up-regulation of pseudopodium formation (Cell Function)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Child - Think about how you have been doing for the past 7 days. Please listen carefully to each sentence and tell me how much of a problem this is for you: It takes me a long time to bathe or shower.", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Young Child Report - Long Time to Bathe or Shower (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as ball luffa.", + "output": "luffa operculata/ball luffa (Homeopathic remedies letter L)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues.", + "output": "mesendoderm development (Organ or Tissue Function)" + }, + { + "input": "Definition: Disease or Syndrome described as recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.", + "output": "CHRONIC MUCOCUTANEOUS CANDIDIASIS (Chronic infectious disease)" + }, + { + "input": "Definition: something described as the removal of an amino group from the side chain of an N-terminal asparagine residue of a protein.", + "output": "N-terminal peptidyl-asparagine deamination (Molecular Function)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane.", + "output": "regulation of sodium ion export across plasma membrane (regulation of sodium ion transmembrane transport)" + }, + { + "input": "Definition: Hereditary Autoinflammatory Diseases described as a family of autoinflammatory diseases caused by gain of function mutations in NLRP3, which encodes cryopyrin, resulting in inflammasome activation and enhanced IL-1 beta and IL-18 production. This results in clinical signs and symptoms of inflammation in the form of rash, fever, joint, neurologic and eye symptoms, with increased acute phase reactants.", + "output": "Cryopyrin-associated periodic syndromes (Musculoskeletal and connective tissue disorders of limbs congenital)" + }, + { + "input": "Definition: something described as a device usually dome-shaped, worn during copulation over the cervical mouth for prevention of conception or infection.", + "output": "Vag Diaphragm (Solid Dose Form)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.", + "output": "CCK(1) Receptor (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.", + "output": "farnesyl diphosphate metabolic process (terpenoid metabolic process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the biotoxin botulinum neurotoxin E12.", + "output": "BOTULINUM NEUROTOXIN E12 (botulinum toxin type E)" + }, + { + "input": "Definition: Tetradecapeptide described as tetradecapeptide; endogenous neurotransmitter in many animals including mammals; affects vascular and other smooth muscle, gastric secretion, and renal circulation and function; originally obtained from the skins of toads of the genus Bombina.", + "output": "Bombesin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Disorder of pelvis described as a traumatic break in one or more of the bones that compose the bony structure of the pelvis.", + "output": "PELVIS FRACTURE (Pelvic injury)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment, the people I worked with: physically forced me to have sex.", + "output": "DRRI-2 - K: Physically Forced to Have Sex (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as an ear, nose, and throat manual surgical instrument is one of a variety of devices intended for use in surgical procedures to examine or treat the bronchus, esophagus, trachea, larynx, pharynx, nasal and paranasal sinus, or ear. This generic type of device includes the esophageal dilator; tracheal bistour (a long, narrow surgical knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tub; tonsil suturing hook; antom reforator; ethmoid curette; frontal sinus-rasp; nasal curette; nasal rasp; nasal rongeur; nasal saw; nasal scissors; nasal snare; sinus irrigator; sinus trephine; ear curette; ear excavator; ear rasp; ear scissor, ear snare; ear spoon; ear suction tub; malleous ripper; mastoid gauge; microsurgical ear chisel; myringotomy tube inserter; ossici holding clamp; sacculotomy tack inserter; vein press; wire ear loop; microrule; mirror; mobilizer; ear, nose, and throat punch; ear, nose and throat knife; and ear, nose, and throat trocar.", + "output": "Tracheotome (scalpel)" + }, + { + "input": "Definition: something described as many people with chronic cancer-related pain experience intermittent flares of pain that can occur even though a person is taking analgesic medications on a fixed schedule for pain control. These severe flares of pain are called breakthrough pain because the pain \"breaks through\" the regular pain medication.", + "output": "Pains, Breakthrough (Sign or Symptom)" + }, + { + "input": "Definition: Certification described as organizations which certify physicians and dentists as specialists in various fields of medical and dental practice.", + "output": "Specialty Boards (health care professions review organization)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate.", + "output": "streptomycin 3''-kinase activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated", + "output": "Grade 3 Pleural Infection, CTCAE (Pleural Infection, CTCAE)" + }, + { + "input": "Definition: Body Location or Region described as a functionally defined ( unit activity correlated with speed of motion ) cortical area located in the anterior bank of the superior temporal sulcus near the supramarginal gyrus in the macaque ( Duffy-1997 ). In the human it is located near the boundary between the temporal lobe and the occipital lobe ( Glasser-2016 ). In humans it is distinguished by multiple criteria, including dense myelination, functional connectivity, and involvement in perception of motion. It is part of the MT+ complex. Other authors have referred to the same topological area as overlapping area MSTv, hOC5, or hOC5v ( Glasser-2016 ).", + "output": "MST (Body Location or Region)" + }, + { + "input": "Definition: Plant described as a plant species of the family FABACEAE.", + "output": "Chinese Licorice (Glycyrrhiza)" + }, + { + "input": "Definition: something described as a change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "output": "follicular dendritic cell activation (Cell Function)" + }, + { + "input": "Definition: Finding described as head and neck cancer with metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+).", + "output": "Head and Neck Cancer pN3b TNM Finding v8 (Head and Neck Cancer pN3 TNM Finding v8)" + }, + { + "input": "Definition: cell-cell junction maintenance described as the maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.", + "output": "adherens junction maintenance (Cell Function)" + }, + { + "input": "Definition: Carcinoma, Large Cell described as a usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6875\" active clinical trials using this agent.", + "output": "large-cell neuroendocrine carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Software, Physiologic Recording described as physiologic recording software designed for later processing of respiratory data obtained while recording. This software is intended to work only with one or a few models of respiratory recorders, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the analysis of measurements performed during recording; it may also be used to send and/or receive patient information from and to hospital information systems. Respiratory recording software is mainly intended for use with the recorders and/or recorded data processors.", + "output": "Software, Physiologic Recording, Respiration (Intellectual Product)" + }, + { + "input": "Definition: Information Resources described as the Cancer Information Service is the National Cancer Institute's link to the public, interpreting and explaining research findings in a clear and understandable manner, and providing personalized responses to specific questions about cancer. Access the CIS by calling 1-800-4-CANCER (1-800-422-6237), or by using the LiveHelp instant-messaging service at https://cissecure.nci.nih.gov/livehelp/welcome.asp.", + "output": "CIS (Intellectual Product)" + }, + { + "input": "Definition: something described as a substructure of the thalamus. It, the Nucleus pulvinaris ventralis (Hassler) and the Nucleus pulvinaris suprabrachialis (Hassler) constitute the inferior pulvinar nucleus ( Mai-1997 ).", + "output": "Nucleus pulvinaris intergeniculatus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: serotonin described as compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups; members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains; they are possibly involved in the etiology of schizophrenia.", + "output": "Meksamine (serotonin)" + }, + { + "input": "Definition: Longitudinal Studies described as investigation in which a group of subjects is recruited and monitored, and from whom data are collected, in accordance with criteria described in the protocol.", + "output": "Study, Prospective (Statistical Theory & Experimentation)" + }, + { + "input": "Definition: Antibiotic described as an antimicrobial lock solution (ALS) containing the nitrate nitroglycerin, sodium citrate and ethanol, with potential antimicrobial and anticoagulant activities. Upon application to the catheter as an ALS, the nitroglycerin is converted into nitric oxide (NO), which exerts antimicrobial activity. The citrate exerts anticoagulant activity, thereby preventing blood clotting and occlusion and maintaining the fluidity of the administered solution. In addition, both citrate and ethanol exert antimicrobial activity. This may prevent bacterial colonization on the surface of the catheter, biofilm formation, and catheter-associated infections. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C124659\" active clinical trials using this agent.", + "output": "GTN-Citrate-Ethanol (Anticoagulants)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.", + "output": "cellular response to caffeine (cellular response to alkaloid)" + }, + { + "input": "Definition: something described as an identifier that describes the relative position of organ measurement data within a series.", + "output": "OMSEQ (Sequence Number)" + }, + { + "input": "Definition: Gene or Genome described as human PROS1 wild-type allele is located in the vicinity of 3q11.2 and is approximately 101 kb in length. This allele, which encodes vitamin K-dependent protein S, is involved in the regulation of coagulation. Mutations in this gene are associated with both autosomal dominant and autosomal recessive thrombophilia due to protein S deficiency.", + "output": "PS22 (Gene or Genome)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: liquiritigenin + NADPH + O2 + H+ <=> 2,4',7-trihydroxyisoflavanone + NADP(3-) + H2O.", + "output": "liquiritigenin,NADPH:oxygen oxidoreductase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: something described as destruction of an epithelial surface extending into or beyond the basement membrane.", + "output": "Ulcerated (Signs and Symptoms)" + }, + { + "input": "Definition: regulation of blood vessel endothelial cell differentiation described as any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment.", + "output": "regulation of venous endothelial cell fate commitment (Cell Function)" + }, + { + "input": "Definition: Applicator - device described as an absorbent tipped applicator is a device intended for medical purposes that consists of an absorbent swab on a wooden, paper, or plastic stick. The device is used to apply medications to, or to take specimens from, a patient.", + "output": "Absorbent tipped applicator, non-sterile (Sponges)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with retinitis pigmentosa, a collection of eye disorders affecting the retina that lead to progressive vision loss. Genetic variants at multiple loci have been associated with retinitis pigmentosa. These reagents are intended to detect mutations in the majority of retinitis pigmentosa-associated loci simultaneously.", + "output": "Comprehensive Retinitis Pigmentosa Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Eye Disorder, Retinopathy, Retinitis Pigmentosa, Comprehensive)" + }, + { + "input": "Definition: pre-miRNA described as MIR10A pre-miRNA is an oligoribonucleotide that is encoded by the human MIR10A gene and has a role in the regulation of gene expression.", + "output": "MIR10A Pre-miRNA (pre-miRNA)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate.", + "output": "cysteine-conjugate alpha-ketoglutarate transaminase (aminotransferase activity)" + }, + { + "input": "Definition: beta Lactamase Inhibitor [EPC] described as a penicillanic acid sulfone derivative and beta-lactamase inhibitor with antibacterial activity. Tazobactam contains a beta-lactam ring and irreversibly binds to beta-lactamase at or near its active site. This protects other beta-lactam antibiotics from beta-lactamase catalysis. This drug is used in conjunction with beta-lactamase susceptible penicillins to treat infections caused by beta-lactamase producing organisms.", + "output": "TAZOBACTAM (Sulfones)" + }, + { + "input": "Definition: Neoplastic Process described as melanoma that occurs in a fish.", + "output": "Fish Melanoma (Neoplastic Process)" + }, + { + "input": "Definition: Recurrent Rhabdoid Tumor described as the reemergence of an atypical teratoid/rhabdoid tumor after a period of remission.", + "output": "Recurrent Atypical Teratoid/Rhabdoid Tumor (Neoplastic Process)" + }, + { + "input": "Definition: something described as a question about what is the other performance status scale about timing.", + "output": "What is the Other Performance Status Scale: Timing (Intellectual Product)" + }, + { + "input": "Definition: Ophthalmological Equipment and Supplies described as an ophthalmic camera is an AC-powered device intended to take photographs of the eye and the surrounding area.", + "output": "Refractors, Ophthalmic (Medical Device)" + }, + { + "input": "Definition: molting cycle process described as attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster.", + "output": "chitin-based cuticle attachment to epithelium (Organ or Tissue Function)" + }, + { + "input": "Definition: Cell Component described as a T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.", + "output": "gamma-delta T lymphocyte receptor complex (T-cell receptor complex location)" + }, + { + "input": "Definition: Special Population described as a group of people characterized by the practice of a common religion.", + "output": "religious denomination (Population Group)" + }, + { + "input": "Definition: regulation of intracellular cholesterol transport described as any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells.", + "output": "negative regulation of intracellular cholesterol transport (negative regulation of cholesterol transport)" + }, + { + "input": "Definition: something described as dilatation of the lumen of the mammary ducts without evidence of epithelial atypia.", + "output": "breast; ectasia (Female breast disorders)" + }, + { + "input": "Definition: Congenital Abnormality described as alveolar cleft is a tornado-shaped bone defect in the maxillary arch. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine. []", + "output": "Alveolar cleft (Congenital Abnormality)" + }, + { + "input": "Definition: something described as any nematode parasite that can be assigned to the species Mansonella streptocerca.", + "output": "MANSONELLA STREPTOCERCA (Eukaryote)" + }, + { + "input": "Definition: something described as abnormally diminished amount of cholesterol in the blood.", + "output": "Cholesterol Serum Decreased (Disorder of lipoprotein AND/OR lipid metabolism)" + }, + { + "input": "Definition: Quantitative Concept described as hours times nanograms per milliliter (area under the curve), divided by milligrams per gram (dose normalized by body weight).", + "output": "h*ng/mL/(mg/g) (Quantitative Concept)" + }, + { + "input": "Definition: Finding described as susceptible to an inability to prepare for a set of actions fixed in time and under certain conditions, which may compromise health.", + "output": "Risk for ineffective activity planning (Finding)" + }, + { + "input": "Definition: Monitors, Physiologic described as bedside monitors designed to continuously measure and display the partial pressure (concentration) of carbon dioxide (PCO2) and/or oxygen (PO2) gases in blood; some monitors can also measure pH. These monitors include electronic circuits that are capable of acquiring and processing signals from one or more sensors, one or more visual displays (e.g., graphic, numeric), and audible/visual alarms. Bedside blood gas monitors may use several mechanisms to acquire data regarding the blood gas concentrations and/or blood pH, including (1) a transcutaneous method, which uses electrode sensors located on the patient's skin surface; (2) an extracorporeal method, which uses a sensor cassette that is inserted in series with the arterial catheter tubing system (these devices typically include a bundle of three detectors that combine an optical fiber with a fluorescent dye [i.e., fluorescent optodes] at their distal tip); and (3) an intravascular method, which uses a vascular catheter equipped with three detectors that combine an optical fiber with a fluorescent dye (i.e., fluorescent optodes) at their distal tip. Blood gas bedside monitors are used in a wide range of applications intended to assess patients' respiratory and metabolic status.", + "output": "Monitors, Bedside, Blood Gas (Medical Device)" + }, + { + "input": "Definition: positive regulation of protein metabolic process described as any process that activates or increases the frequency, rate or extent of amyloid fibril formation.", + "output": "up regulation of amyloid fibril formation (regulation of amyloid fibril formation)" + }, + { + "input": "Definition: Special Histology Staining Method described as immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.", + "output": "Immunohistochemistry technique (Histology Procedure)" + }, + { + "input": "Definition: Complication of procedure described as a subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with radiation. The neoplastic cells typically harbour unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. Patients frequently present with multilineage dysplasia and cytopenias 5-10 years after exposure.", + "output": "acute therapy related myeloid leuk & myelodysplas syn related to radiation (Disorder following clinical procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.", + "output": "GTP diphosphate-lyase (cyclizing) activity (cyclase activity)" + }, + { + "input": "Definition: Alveolar Epithelial Cells described as cuboidal epithelial cells that line the PULMONARY ALVEOLI and produce and secret PULMONARY SURFACTANTS.", + "output": "Pneumocyte, Type-II (Alveolar Epithelial Cells)" + }, + { + "input": "Definition: something described as a clinical geneticist demonstrates competence in providing comprehensive diagnostic, management and counseling services for genetic disorders.", + "output": "Clinical Genetics Physician (Physicians; Physician/Osteopath)" + }, + { + "input": "Definition: Quantitative Concept described as the standard character or string for representation and reporting of subject status data.", + "output": "Subject Status Character Result in Standard Format (Character Result or Finding in Standard Format)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the usual severity of an individual's itching.", + "output": "Usual Severity Itching (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as an indication that MAGEA12 expression has been detected in a sample.", + "output": "Melanoma-Associated Antigen 12 Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: Disease Laboratory Finding Qualifier described as taken from an individual's own tumor tissue; may be used in the development of a vaccine that enhances the body's ability to build an immune response to the tumor.", + "output": "Tumor-Derived (Functional Concept)" + }, + { + "input": "Definition: something described as purchasers are provided information on the quality of health care, including patient outcomes and health status, with data on the dollar outlays going towards health. The focus is on managing the use of the health care system to reduce inappropriate care and to identify and reward the best-performing providers.", + "output": "Purchasings, Value-Based (Health Insurance)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) Because of your health condition, in the past 30 days how much difficulty did you have in: Doing your most important work/school tasks well?", + "output": "WD5-Doing Important Work/School Tasks (Intellectual Product)" + }, + { + "input": "Definition: Spondylolysis described as spondylolysis, the cause of which is present from birth.", + "output": "congenital; spondylolysis (Congenital Abnormality)" + }, + { + "input": "Definition: Medical Device described as a calibrator for red cell and white cell counting is a device that resembles red or white blood cells and that is used to set instruments intended to count red cells, white cells, or both. It is a suspension of particles or cells whose size, shape, concentration, and other characteristics have been precisely and accurately determined.", + "output": "CALIBRATOR FOR RED-CELL AND WHITE-CELL COUNTING (Medical Device)" + }, + { + "input": "Definition: something described as a plant genus of the family RANUNCULACEAE.", + "output": "Nigella (Plant)" + }, + { + "input": "Definition: Estrogens, Synthetic described as a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.", + "output": "17-ethinyl-3,17-estradiol (estrogens)" + }, + { + "input": "Definition: Assessment scales described as a list of five factors that help doctors assess how a non-Hodgkin lymphoma patient might respond to a certain treatment or predict the risk of disease recurrence and survival following therapy. The factors are: 1) patient's age, 2) stage of disease: an indication of how localized or widespread is the disease, 3) LDH levels: serum levels often correlate with the amount of tumor in the body, 4) the number of extranodal, non-lymphatic sites found, 5) the patient's overall health. (from Lymphoma Research Foundation of America glossary (www.lymphoma.org))", + "output": "IPI (Assessment scales)" + }, + { + "input": "Definition: something described as an decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.", + "output": "hypomethylation of CpG island (Hypomethylation)" + }, + { + "input": "Definition: something described as a ribosome contained within a plastid.", + "output": "plastid ribosome (organellar ribosome)" + }, + { + "input": "Definition: something described as the process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.", + "output": "neuroblast fate specification (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the organizational units within the National Cancer Insitute (NCI) (divisions, programs and offices) that provide funding. EXAMPLE(S): CTEP (Cancer Therapy Evaluation Program) DTP (Developmental Therapeutics Program) CDP (Cancer Diagnosis Program) OTHER NAME(S): NOTE(S):", + "output": "Government Funding NCI Program Code (Intellectual Product)" + }, + { + "input": "Definition: something described as zinc-binding, DNA-binding motifs in proteins contain amino acids that are folded into a single DNA-binding structural unit around a zinc atom.", + "output": "Zinc Finger Domain (Metal Binding Site)" + }, + { + "input": "Definition: Organic Chemical described as the resinous oil tapped from the trunks of Copaifera reticulata. Copaiba oil is used medicinally for its ability to modulate the inflammatory process.", + "output": "Oil of copaiba (Organic Chemical)" + }, + { + "input": "Definition: Tracheophyta described as a class of vascular plants which produce flowers and seeds. They include monocotyledons, dicotyledons, and about 80% of all known plant species.", + "output": "Hamamelididae (ANGIOSPERMS - FLOWER-BEARING PLANTS)" + }, + { + "input": "Definition: Immunologic Factor described as a cell-based vaccine composed of irradiated tumor cells transduced with granulocyte-macrophage colony-stimulating factor (GM-CSF) and CD40-ligand (CD40L) genes. Upon administration, this vaccine may stimulate an anti-tumoral dendritic cell-mediated host immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48391\" active clinical trials using this agent.", + "output": "GM.CD40L (Immunologic Factor)" + }, + { + "input": "Definition: something described as the overall rationale, reason, or intention of the clinical study.", + "output": "Study Purpose (Research Methodology)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen) In the past 7 days, how much of a problem has this been for your teen: I think our family has a lot of problems.", + "output": "PQL13-Family Has Lot of Problems (Intellectual Product)" + }, + { + "input": "Definition: something described as drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2E1.", + "output": "Inducers, P450 CYP2E1 (Cytochrome P-450 Enzyme Inducers)" + }, + { + "input": "Definition: Anatomical Abnormality described as increased width of the radius.", + "output": "Wide radius (Broad forearm bones)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate.", + "output": "sulfite oxidase activity (Molecular Function)" + }, + { + "input": "Definition: Listeria described as any bacterial organism that can be assigned to the species Listeria welshimeri.", + "output": "LISTERIA WELSHIMERI (Bacterium)" + }, + { + "input": "Definition: Problem described as any problem that remains unresolved regarding proper documentation of the Administered Item.", + "output": "Unresolved Issue (Idea or Concept)" + }, + { + "input": "Definition: Intellectual Product described as michigan Neuropathy Screening Instrument - History: Are your feet too sensitive to touch?", + "output": "MNSI1-Are Feet Too Sensitive to Touch (Intellectual Product)" + }, + { + "input": "Definition: Western herbs and natural substances letter O described as a plant species, of the genus OENOTHERA, family ONAGRACEAE, that is the source of evening primrose oil.", + "output": "Primrose, Evening (Western herbs and natural substances letter O)" + }, + { + "input": "Definition: Laboratory or Test Result described as an indication that CDKN2A-p16 expression has been detected in a sample using immunohistochemical techniques.", + "output": "CDKN2A-p16 Positive by Immunohistochemistry (CDKN2A-p16 Positive)" + }, + { + "input": "Definition: Unit of volume per unit area described as liters per minute (flow rate), divided by meters squared (surface area).", + "output": "Liters per Minute per Square Meter (Volume per unit time per unit area)" + }, + { + "input": "Definition: something described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I felt valued by the leaders of my unit.", + "output": "DRRI-2 - J: Felt Valued by Leaders of Unit (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: intracellular signal transduction described as any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.", + "output": "small GTPase mediated signal transduction (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as patient Health Questionnaire Screener Version (PHQ Screener Version) During the last 4 weeks, how much have you been bothered by nausea, gas, indigestion?", + "output": "PHQ03-Nausea/Gas/Indigestion (PHQ Screener Version Questionnaire Question)" + }, + { + "input": "Definition: something described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated", + "output": "Grade 3 Appendicitis, CTCAE (Appendicitis, CTCAE)" + }, + { + "input": "Definition: something described as a coded value specifying the domestic partnership status of a person.", + "output": "Person.maritalStatusCode (Marital Status Code)" + }, + { + "input": "Definition: Respiratory Tract Infections described as gram negative bacterial infection by any species of Legionella including Legionnaire's disease, which is characterized by high fever, malaise, muscle aches, respiratory disorders and headache.", + "output": "Legionella infection NOS (Gram-Negative Bacterial Infections)" + }, + { + "input": "Definition: U12-type spliceosomal complex described as a spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs.", + "output": "U12-type activated spliceosome (catalytic step 1 spliceosome)" + }, + { + "input": "Definition: Cell Component described as a multisubunit protein complex that plays a central role in chromosome condensation.", + "output": "condensin complex (Cell Component)" + }, + { + "input": "Definition: Metabolism described as sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of neurotransmitters; the buildup and breakdown of neurotransmitters for utilization by the organism.", + "output": "neurotransmitter metabolism (Cell Function)" + }, + { + "input": "Definition: Medical Device described as image digitization systems designed to use fluoroscopic detection and imaging processing techniques to provide real-time images in the verification of radiation treatment. Digital portal imaging systems typically incorporate a detector assembly (usually mounted on the linear accelerator gantry), a computer system for image processing, and peripherals for hard-copy printing and/or image storage. These systems provide an alternative to the traditional method of processing port films.", + "output": "Image Digitization Systems, Portal (Image Digitization Systems)" + }, + { + "input": "Definition: Neoplastic Process described as stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage II Colorectal Cancer (Colorectal Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: FACT-B Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Breast Version 4 - Physical Well-Being: I have nausea.", + "output": "FACT-B Version 4 - I Have Nausea (FACT-B Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Disease or Syndrome described as the most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum.", + "output": "Multiple Sclerosis, Relapsing-Remitting (Multiple Sclerosis)" + }, + { + "input": "Definition: Intellectual Product described as terminology associated with the analysis purpose codelist of the Clinical Data Interchange Standards Consortium (CDISC) Define-XML standard.", + "output": "ANLPURP (CDISC Define-XML Terminology)" + }, + { + "input": "Definition: Retractors, Surgical described as surgical retractors designed to temporarily separate and hold back segments of the vasculature, exposing and providing access to other anatomical structures. These retractors consist of handheld, manual instruments in a variety of shapes and sizes, including double-ended instrument with perpendicular blunt blades and retractors including angulated shaft ended in a blade perpendicular to the shaft at the distal end. Vascular retractors are used in a great variety of surgical procedures, including thoracic, abdominal, brain, and peripheral surgery procedures. Dedicated vessel retractors intended to hold the aorta and the peripheral vessels are also available.", + "output": "Retractors, Vessel (Medical Device)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores.", + "output": "microspore development (Organ or Tissue Function)" + }, + { + "input": "Definition: Organism Function described as positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.", + "output": "helper T cell enhancement of T cell mediated immune response (positive regulation of T cell mediated immunity)" + }, + { + "input": "Definition: Panniculitis described as a very rare autosomal recessive metabolic disorder affecting lipid metabolism. It is caused by mutations in the ASAH1 gene and is characterized by fatty accumulation in the body tissues. Patients develop lipogranulomas in the skin and internal organs, edema and pain in the joints and a hoarse voice. It may be associated with intellectual disability.", + "output": "CERAMIDASE DEFICIENCY (Lipid Metabolism Disorders)" + }, + { + "input": "Definition: something described as a non-metastasizing neoplasm arising from the gallbladder wall.", + "output": "Benign tumour of gallbladder (Benign neoplasm of intra-abdominal organs)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about how your activities might be affected by your respiratory problems: My breathing makes it difficult to do things such as carry heavy loads, dig in the garden or shovel snow, jog or walk briskly (5 miles per hour), play tennis or swim.", + "output": "SGRQ0244 (Intellectual Product)" + }, + { + "input": "Definition: Congenital Heart Defects described as a condition characterized by a combination of OSTIUM SECUNDUM ATRIAL SEPTAL DEFECT and an acquired MITRAL VALVE STENOSIS.", + "output": "Lutembacher Syndrome (Congenital abnormality of cardiac connection)" + }, + { + "input": "Definition: something described as the highest federal court in the United States, consisting of nine justices and having jurisdiction over all other courts in the nation.", + "output": "US Supreme Court (Organization)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as core histone macro-H2A.2 (372 aa, ~40 kDa) is encoded by the human MACROH2A2 gene. This protein plays a role in nucleosome formation and transcriptional repression.", + "output": "MACROH2A2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Body Location or Region described as the forepart of the foot including the metatarsals and the TOES.", + "output": "Forefoot, Human (Body Location or Region)" + }, + { + "input": "Definition: Hereditary disorder of the integument described as a rare form of genetic lipodystrophy with loss of subcutaneous adipose tissue from the trunk, buttocks and limbs; fat accumulation in the neck, face, axillary and pelvic regions; muscular hypertrophy; and usually associated with metabolic complications such as insulin resistance. Inherited in an autosomal dominant manner.", + "output": "LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2 (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Eyelid Carcinoma by AJCC v7 Stage described as stage IIIC includes: T4, Any N, M0. T4: Tumor is not resectable due to extensive invasion of ocular, orbital, craniofacial structures, or brain. M0: No distant metastasis.", + "output": "Stage IIIC Eyelid Carcinoma AJCC v7 (Eyelid Carcinoma by AJCC v7 Stage)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers.", + "output": "neuromelanin anabolism (Molecular Function)" + }, + { + "input": "Definition: SOAPP-R Questionnaire Question described as screener and Opioid Assessment for Patients with Pain - Revised (SOAPP-R) How often is there tension in the home?", + "output": "SOAPR105 (SOAPP-R Questionnaire Question)" + }, + { + "input": "Definition: catheter device described as a catheter designed for drug administration through a rectal route of delivery. It is specifically designed for rectal administration of liquid medication, especially when a patient is unable to take medications orally.", + "output": "Macy Catheter (Medical Device)" + }, + { + "input": "Definition: something described as the determination of the amount of interferon-induced protein 44 present in a sample.", + "output": "IFI44 Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Batrachia described as an order of the Amphibia class which includes salamanders and newts. They are characterized by usually having slim bodies and tails, four limbs of about equal size (except in Sirenidae), and a reduction in skull bones.", + "output": "ORDER CAUDATA - SALAMANDERS (Batrachia)" + }, + { + "input": "Definition: Kidney described as the presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria.", + "output": "Light negative GN (Glomerulonephritis and nephrotic syndrome)" + }, + { + "input": "Definition: Cell Function described as the directed movement of arginine across a membrane.", + "output": "arginine transmembrane transport (Cell Function)" + }, + { + "input": "Definition: Medical Device described as central venous infusion catheters designed for direct insertion into the selected vein (typically, the subclavian or internal jugular veins are used). The distal tip is usually advanced to the superior vena cava. The length of these catheters is typically 20 cm (8 inches) for adult use, but may be 15 cm (6 inches) for smaller adults and even smaller for pediatric use. Some 30 cm (12 inch) versions are used for left subclavian insertions and for larger adults. The Seldinger over-the-wire technique is the most common insertion method used. These catheters are used for short-term periods and acute-care needs.", + "output": "Catheters, Vascular, Infusion, Central Venous, Percutaneous (Central venous catheter, device)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+.", + "output": "citronellyl-CoA dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: something described as an increase in matrix, without an increase in cell numbers, between the endothelium and the internal elastic lamina.", + "output": "PIT (Finding)" + }, + { + "input": "Definition: something described as the region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.", + "output": "nucleoid (cellular anatomical entity)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Additional Concerns: I have a good appetite.", + "output": "FAC01633 (Intellectual Product)" + }, + { + "input": "Definition: something described as the area under the first moment curve (AUMC) extrapolated to infinity, based on the last predicted concentration divided by the surface area.", + "output": "AUMCIFPS (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as a 10-item scale for the subjective scoring of a person's self esteem, developed by Dr. Morris Rosenberg, that ranges from strongly agree to strongly disagree. Five of the items have positively worded statements and five have negatively worded statements.", + "output": "Rosenberg (Intellectual Product)" + }, + { + "input": "Definition: Cell Component described as a protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides.", + "output": "methanophenazine reducing hydrogenase complex (Cell Component)" + }, + { + "input": "Definition: something described as a triplet codon-amino acid adaptor activity that recognizes an ACG codon.", + "output": "ACG codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: divalent metal ion transport described as the directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "cadmium transport (divalent metal ion transport)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Teen - In the past one month, how much of a problem has this been for you: I take a long time to eat.", + "output": "PedsQL Neuromuscular Module Version 3.0 Teen Report - Take Long Time to Eat (Intellectual Product)" + }, + { + "input": "Definition: Carcinogenicity Tests described as this in vitro invasion assay utilizes matrigel, a reconstituted basement membrane, to assess the ability of cells to degrade and cross tissue barriers. This \"in-vitro angiogenesis assay\" can be used to screen potential anti-angiogenic compounds as well as to study angiogenic pathways underlying neoplasia.", + "output": "Matrigel Invasion Assay (Carcinogenicity Tests)" + }, + { + "input": "Definition: Medical Device described as linear-accelerator-based radiotherapy systems designed to deliver radiation combining computer-controlled beam-shaping (known as intensity modulated radiation therapy [IMRT]) and spiral scanning to deliver the radiation slice by slice rather than all the volume at once. These systems provide image guidance before and during (i.e., in real-time) the radiation treatment. These systems deliver radiation following the three-dimensional image of the tumor, adjusting the intensity of the radiation across the treatment area by using the properties of a spiral scanning accelerator and dedicated software. Spiral scanning linear accelerator radiotherapy systems are intended to deliver more accurate and higher doses of radiation to the tumors in order to spare adjacent tissues. The systems may also be used for single-dose (radiosurgical) treatments, especially in the treatment of cancers of the brain, as well as head and neck tumors.", + "output": "Spiral Tomotherapy Systems (Radiotherapy Systems, Linear Accelerator)" + }, + { + "input": "Definition: Geographic Area described as a census division of the United States consisting of Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, and West Virginia.", + "output": "Census Division 5 (Geographic Area)" + }, + { + "input": "Definition: CNS inflammation or infection described as diffuse disease of the brain that alters function and/or structure of the brain and is characterized by an altered mental state.", + "output": "encephalopathy nos (encephalopathies and hydrocephalies)" + }, + { + "input": "Definition: Homologous Recombination Repair Gene described as this gene plays a role in cell cycle control, regulation of transcription and the maintenance of genomic stability. It is also involved in the inhibition of mammary cell growth.", + "output": "Gene, BRCA1 (Gene or Genome)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O.", + "output": "2-hydroxylaminobenzoate reductase activity (oxidoreductase activity, acting on the CH-NH2 group of donors)" + }, + { + "input": "Definition: paclitaxel described as a paclitaxel formulation containing paclitaxel incorporated in biodegradable polyphosphoester (PPE) polymer form with potential antineoplastic activity. Upon intraperitoneal delivery, paclitaxel PPE microspheres slowly and continuously dissolve and deliver paclitaxel to the tumor site, where it binds to tubulin and inhibits the dynamics of disassembly-assembly of microtubules. As a result, this formulation induces cell cycle arrest and leads to cell death.", + "output": "Paclitaxel PPE Microspheres (paclitaxel)" + }, + { + "input": "Definition: something described as a preparation of human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20, CD22 and CD30, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22/CD30 CAR-T cells target and bind to CD19, CD20, CD22 and CD30 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies.", + "output": "anti-CD19/CD20/CD22/CD30 chimeric antigen receptor-T cells (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as syndrome that is characterised by total colour blindness caused by progressive cone dystrophy, degenerative liver disease, and endocrine dysfunction (hypothyroidism, diabetes, repeated abortions or infertility). It has been described in six females from two sibships with a high degree of consanguinity, and in a male from another family.", + "output": "Retinohepatoendocrinologic Syndrome (Liver diseases)" + }, + { + "input": "Definition: Mental Process described as ability to interpret the feelings and emotions of another individual based on their vocal expressions.", + "output": "Voice Emotion Recognitions (Mental Process)" + }, + { + "input": "Definition: Central African country described as a country in Central Africa, north of Democratic Republic of the Congo.", + "output": "CENTRAL AFRICAN REPUBLIC (Central African country)" + }, + { + "input": "Definition: something described as a genus of fungi in the family Pleosporaceae. Species within this genus are commonly found on dead leaves and stems.", + "output": "PITHOMYCES (Fungus)" + }, + { + "input": "Definition: something described as a pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2416\" active clinical trials using this agent.", + "output": "5-Chloro-2,4-dihydroxypyridine (Organic Chemical)" + }, + { + "input": "Definition: something described as a group of iron-binding proteins that tightly bind two ferrate ions along with two carbonate ions. They are found in the bodily fluids of vertebrates where they act as transport and storage molecules for iron.", + "output": "Transferrins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Symphalangism, Distal described as the term distal symphalangism refers to a bony fusion of the distal and middle phalanges of the digits of the hand, in other words the distal interphalangeal joint (DIJ) is missing which can be seen either on x-rays or as an absence of the distal interphalangeal finger creases.", + "output": "Terminal symphalangism (Abnormal distal phalanx morphology of finger)" + }, + { + "input": "Definition: something described as a nuclear flood source phantom is a device that consists of a radiolucent container filled with a uniformly distributed solution of a desired radionuclide. It is intended to calibrate a medical gamma camera-collimator system for uniformity of response.", + "output": "PHANTOM, FLOOD SOURCE, NUCLEAR (Medical Device)" + }, + { + "input": "Definition: transcription regulator complex described as a dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.", + "output": "ModE dimer (Cell Component)" + }, + { + "input": "Definition: Personality described as complex of personality characteristics expressed as antidemocratic social attitudes, rigid attachment to traditional values, uncritical acceptance of authority, and intolerance of opposing views.", + "output": "Authoritarianism (Personality Traits)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - Confusion is defined as intermittent or persistent disorganized thinking, perceptual disturbances or disorientation to time, place, or person. Does the examiner believe the subject is confused?", + "output": "UDHR1-Examiner Believe Subject Confused (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as a branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care.", + "output": "Ethics, Biomedical (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: something described as increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.", + "output": "protein phosphatase activator activity (protein phosphatase regulator activity)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Baseline (C-SSRS Baseline) Description of aborted attempt.", + "output": "CSS01-Aborted Attempt, Describe (C-SSRS Baseline Questionnaire Question)" + }, + { + "input": "Definition: Clinical Trials described as phase 3. Studies are expanded controlled and uncontrolled trials. They are performed after preliminary evidence suggesting effectiveness of the drug has been obtained, and are intended to gather the additional information about effectiveness and safety that is needed to confirm efficacy and evaluate the overall benefit-risk relationship of the drug and to provide an adequate basis for physician labeling. NOTE: Phase 3 studies usually include from several hundred to several thousand subjects. [After FDA CDER Handbook, ICH E8]", + "output": "Clinical Trials, Phase III (Clinical Trials)" + }, + { + "input": "Definition: Adenovirus antibody described as an antibody produced in response to exposure to adenovirus serotype 5.", + "output": "Adenovirus Serotype 5 Antibody (Immunologic Factor)" + }, + { + "input": "Definition: something described as eliminating danger and protection from the occurrence or risk of injury or loss in diagnostic procedures; optimal precautions in the procedure, as well as the safety of equipment used.", + "output": "diagnosis procedure safety (Qualitative Concept)" + }, + { + "input": "Definition: Abnormal proportion of transitional B cells described as an elevation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells.", + "output": "Increased proportion of CD19+CD38+IgM+ cells (Finding)" + }, + { + "input": "Definition: Medical Device described as prepackaged collections of the devices and supplies (either custom or standard) needed for the insertion of a catheter whose tip will reach the central venous system. The catheters are usually inserted into a large vein in the neck (internal or external jugular vein), chest (subclavian vein), or groin (femoral vein). Items in these kits may include gauge needles, sterile gloves, appropriate intravenous (IV) catheters, alcohol swabs, gauze pads, IV bags with solution, and tubing. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Central intravenous catheterization procedure kits and trays are intended for use during a variety of procedures, including the administration of fluids (e.g., medication, parenteral feeding), to perform central venous pressure measurements, and/or for other blood tests. They are used in hospitals (e.g., intensive and emergency care) and other healthcare facilities.", + "output": "Procedure Kit/Trays, Catheterization, Intravenous, Central Vein (Procedure Kit/Trays, Catheterization, Intravenous)" + }, + { + "input": "Definition: Abnormality of binocular vision described as diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.", + "output": "seeing double (Abnormality of binocular vision)" + }, + { + "input": "Definition: phosphoric monoester hydrolase activity described as catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.", + "output": "alkaline phosphatase activity (Molecular Function)" + }, + { + "input": "Definition: Neoplastic Process described as a non-metastasizing neoplasm that arises from the nasal cavity. Representative examples include Schneiderian papilloma and salivary gland-type adenoma.", + "output": "Benign Tumor of the Nasal Cavity (Neoplasm of nasal cavity)" + }, + { + "input": "Definition: something described as region of myocardium which has as its parts the cardiac muscle tissue, posterior division of left branch of atrioventricular bundle, the cardiac muscle of left ventricle and the fibrocollagenous sheath of cardiac muscle tisuue that is located on the posterior part of the apex zone of myocardium of left ventricle.", + "output": "Myocardium of zone 20 of left ventricle (Body Location or Region)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.", + "output": "glycogen phosphorylase activity (Molecular Function)" + }, + { + "input": "Definition: distal convoluted tubule development described as the process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter.", + "output": "metanephric distal convoluted tubule development (metanephric nephron tubule development)" + }, + { + "input": "Definition: Medical Device described as multianalyte point-of-care analyzers designed to determine the concentration of analytes in the blood and urine that is appropriate for diabetes disease management. The most frequently measured analytes are glycated hemoglobin (GHB), also known as glycohemoglobin, in whole blood, and urine creatinine and albumin. The amount of GHB in blood represents the integrated values for glucose for the previous three months; the value of the albumin/creatinine ratio may be an indicator of microalbuminuria. These devices typically consist of a portable analyzer that includes a reagent cartridge to collect and assess the samples; they may use several measuring techniques, including photometry and immunoassay. Point-of-care analyzers for diabetes management are used in clinics and physician's offices to obtain criteria in assessing glucose control and/or to find early signs of possible diabetes-related nephropathy.", + "output": "Analyzers, Point-of-Care, Whole Blood/Urine, Multianalyte, Diabetes (Medical Device)" + }, + { + "input": "Definition: Finding described as the response to a defined eligibility criterion question.", + "output": "DefinedEligibilityCriterionAnswer (Finding)" + }, + { + "input": "Definition: Homeopathic remedies letter S described as soap root.", + "output": "Saponaria officinalis / soap root (Pharmacologic Substance)" + }, + { + "input": "Definition: JUN Proto-oncogene Family described as this gene plays a role in transcriptional regulation and myelopoiesis.", + "output": "ONCOGENE JUN-B (Gene or Genome)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate.", + "output": "soyasapogenol B glucuronosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).", + "output": "cAMP response element binding protein binding activity (DNA-binding transcription factor binding)" + }, + { + "input": "Definition: something described as severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL", + "output": "Grade 3 Fibrosis deep connective tissue (Finding)" + }, + { + "input": "Definition: Enzyme described as receptor-interacting serine/threonine-protein kinase 3 (518 aa, ~57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the induction of necrosis.", + "output": "EC 2.7.11.1 (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) How often in the last week did your child get together and do things with friends?", + "output": "PODCI Pediatric Parent-Reported Version - Get Together With Friends (Intellectual Product)" + }, + { + "input": "Definition: Wellness and Lifestyle described as condition of the mouth, teeth, gums, and tongue", + "output": "Health, Oral (PHYSIOLOGICAL DOMAIN)" + }, + { + "input": "Definition: Quantitative Concept described as a measurement of the distance between the rectal tumor and the anal margin.", + "output": "RTAVDIST (Distance)" + }, + { + "input": "Definition: Intellectual Product described as an alphabetical list of technical terms in some specialized field of knowledge; usually published as an appendix to a text on that field.", + "output": "Glossaries (vocabulary list)" + }, + { + "input": "Definition: C [Preparations] described as the hemihydrate form of cefadroxil, a semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil hemihydrate binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.", + "output": "cefadroxil hemihydrate (Antibiotic)" + }, + { + "input": "Definition: something described as the biotoxin botulinum neurotoxin F6.", + "output": "Botulinum Toxin Type F6 (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as the date and time of a questionnaire reference point.", + "output": "Questionnaire Date Time of Reference Timepoint (Temporal Concept)" + }, + { + "input": "Definition: something described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray.", + "output": "SYSTEM, HEMODIALYSIS, ACCESS RECIRCULATION MONITORING (Medical Device)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes.", + "output": "acetylene metabolism (cellular alkyne metabolic process)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "output": "regulation of myeloid dendritic cell cytokine production (regulation of myeloid leukocyte mediated immunity)" + }, + { + "input": "Definition: Hyperlipidemia described as an abnormal increase in the level of lipoprotein cholesterol in the blood.", + "output": "Hyperlipoproteinemia, NOS (Hyperlipoproteinemias)" + }, + { + "input": "Definition: Ovarian Failure, Premature described as absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.", + "output": "Primary Ovarian Insufficiency (ENDOCRINE FEATURES)" + }, + { + "input": "Definition: something described as lung cancer with distant metastasis.", + "output": "pM1 Lung Cancer v6 (Finding)" + }, + { + "input": "Definition: something described as an evaluation of the soft tissue response of the disease to the therapy.", + "output": "SFTSRESP (Finding)" + }, + { + "input": "Definition: respiratory obstructive disorders described as an abnormal passage or communication between a bronchus and another part of the body.", + "output": "bronchial fistula (respiratory obstructive disorders)" + }, + { + "input": "Definition: polyol metabolic process described as the chemical reactions and pathways involving neomycin.", + "output": "neomycin metabolism (aminoglycoside antibiotic metabolic process)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an acid phosphatase (total or prostatic) test system is a device intended to measure the activity of the acid phosphatase enzyme in plasma and serum.", + "output": "ACID PHOSPHATASE, NITROPHENYLPHOSPHATE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a grammatically functional change in the pitch or loudness of the voice. Also, the syntactic change in words to designate such factors as case, gender, or tense.", + "output": "Inflection (Prosody)" + }, + { + "input": "Definition: Chromosome 17 Physical Location described as physical location of CCL14_Gene", + "output": "17: 31337852-31334805 (Chromosome 17 Physical Location)" + }, + { + "input": "Definition: Congenital Abnormality described as ovotesticular differences of sex development in individuals with 46,XX karyotype.", + "output": "46,XX Ovotesticular Difference of Sex Development (Sex Differentiation Disorders)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "catabolism by symbiont of host cell wall chitin (Organism Function)" + }, + { + "input": "Definition: Steroid Sulfatase Deficiency Disease described as sex linked inherited disease characterized by excessive scaling", + "output": "Deficiency, Steroid Sulfatase (Reproductive system hereditary disorder)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as the Oswestry Disability Index Version 2.1a test name.", + "output": "The Oswestry Disability Index Version 2.1a Questionnaire Test Name (Intellectual Product)" + }, + { + "input": "Definition: Thiazin dye described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.", + "output": "Azure C stain (Thiazin dye)" + }, + { + "input": "Definition: Stage I Indolent Adult Non-Hodgkin Lymphoma described as ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8070\" active clinical trials using this agent.", + "output": "Small Lymphocytic Lymphoma Stage I (Small Lymphocytic Lymphoma by Ann Arbor Stage)" + }, + { + "input": "Definition: Receptor Mediated Endocytosis described as any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.", + "output": "receptor-mediated endocytosis of virus by host cell (viral entry into host cell via endocytosis)" + }, + { + "input": "Definition: Abnormal middle phalanx morphology of the hand described as an abnormally round shape of the middle phalanx of the finger.", + "output": "Rounded middle bone of finger (Abnormal middle phalanx morphology of the hand)" + }, + { + "input": "Definition: something described as catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine.", + "output": "D-methionine-pyruvate aminotransferase activity (aminotransferase activity)" + }, + { + "input": "Definition: Neoplastic Process described as a usually aggressive malignant neoplasm arising from the heart. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.", + "output": "Heart Fibrosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Relocation Adaptation described as feeling of distress or apprehension whose source is unknown", + "output": "angst (Pain: Adverse Psychological Response)" + }, + { + "input": "Definition: P [Preparations] described as a nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pyridoxine helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly. Pyridoxine is a group of related compounds (pyridoxine, pyridoxal, and pyridoxamine) found in cereals, beans, peas, nuts, meat, poultry, fish, eggs, and bananas. It is water-soluble (can dissolve in water). Not enough pyridoxine can cause mouth and tongue sores and nervous disorders. Pyridoxine is being studied in the prevention of hand-foot syndrome (a disorder caused by certain anticancer drugs and marked by pain, swelling, numbness, tingling, or redness of the hands or feet).", + "output": "3,4-Pyridinedimethanol, 5-hydroxy-6-methyl- (Pharmacologic Substance)" + }, + { + "input": "Definition: Unit of Specific Radioactivity described as a unit of specific radioactivity (massic activity) equal to activity of one Curie of the sample with total mass of one gram.", + "output": "uCi/ug (Unit of Specific Radioactivity)" + }, + { + "input": "Definition: permeabilization of host organelle membrane involved in viral entry into host cell described as induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm.", + "output": "macropinosomal membrane permeabilization involved in viral entry into host cell (permeabilization of host organelle membrane involved in viral entry into host cell)" + }, + { + "input": "Definition: anatomical structure development described as the developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "output": "embryonic heart tube elongation (anatomical structure development)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to get in or out of a car without assistance.", + "output": "Getting in or out of a car (Intellectual Product)" + }, + { + "input": "Definition: something described as physical location of GAS2_Gene", + "output": "11: 22646230-22791123 (Spatial Concept)" + }, + { + "input": "Definition: something described as an indication of the organizational role of a human observer.", + "output": "Person Observer Role in Organization (Intellectual Product)" + }, + { + "input": "Definition: Eucommia described as du zhong", + "output": "Eucommia / du zhong (Plant)" + }, + { + "input": "Definition: Embryonic Structure described as the third and final stage of mammalian kidney (pro-, meso-, meta-) development, which takes place within the intermediate mesoderm.", + "output": "Primordium of Permanent Kidney (Embryonic Structures)" + }, + { + "input": "Definition: AIDS Treatment Research described as AIDS related research with a minimum of 20% (or $100,000) relevance to individuals with hemophilia, a sex-linked hereditary blood defect that occurs almost exclusively in males and is characterized by delayed clotting of the blood and consequent difficulty in controlling hemorrhage even after minor injuries.", + "output": "AIDS in Hemophiliac Population (AIDS Treatment Research)" + }, + { + "input": "Definition: Finding described as sperm cells lacking flagella.", + "output": "Absent sperm flagella (Finding)" + }, + { + "input": "Definition: Africa, Western described as a republic in western Africa, southwest of ALGERIA and west of MALI. Its capital is Nouakchott.", + "output": "Mauritania (Country)" + }, + { + "input": "Definition: nephron tubule morphogenesis described as the process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.", + "output": "proximal tubule morphogenesis (nephron tubule morphogenesis)" + }, + { + "input": "Definition: Neoplastic Process described as a pilomyxoid astrocytoma that occurs during childhood.", + "output": "Pilomyxoid Astrocytoma (Pilomyxoid astrocytoma)" + }, + { + "input": "Definition: something described as the determination of the number of nucleated red blood cells present in a sample.", + "output": "Nucleated Erythrocytes (Red Blood Cell Count measurement)" + }, + { + "input": "Definition: something described as problem associated with a cloud of vapor or gas generated from the device, generally associated after a fire or a burn.", + "output": "Medical Device Emits Smoke (Finding)" + }, + { + "input": "Definition: Moraxella catarrhalis described as any bacterial organism that can be assigned to the species Moraxella catarrhalis and is beta-lactamase positive.", + "output": "MORAXELLA CATARRHALIS, BETA-LACTAMASE POSITIVE (Moraxella catarrhalis)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Tracheal mucositis (Tracheal Mucositis, CTCAE)" + }, + { + "input": "Definition: something described as compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.", + "output": "Compounds, Diphenylmethyl (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as information collected from a subject and presented on a case report form.", + "output": "Case Report Form Data (Data)" + }, + { + "input": "Definition: CDISC Protocol Terminology described as a terminology value set relevant to the attributes of the clinical trial entity.", + "output": "CDISC Protocol Entities Clinical Trial Attribute Terminology (Intellectual Product)" + }, + { + "input": "Definition: metabolism of substance in other organism involved in symbiotic interaction described as the chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.", + "output": "metabolism by host of substance in symbiont (Organism Function)" + }, + { + "input": "Definition: something described as subsequent to; after.", + "output": "Since (Temporal Concept)" + }, + { + "input": "Definition: something described as human KATNAL2 wild-type allele is located in the vicinity of 18q21.1 and is approximately 102 kb in length. This allele, which encodes katanin p60 ATPase-containing subunit A-like 2 protein, is involved in both ATP hydrolysis and microtubule depolymerization.", + "output": "Katanin p60 Subunit A-Like 2 Gene (KATNAL2 gene)" + }, + { + "input": "Definition: something described as a data type comprised of a collection of a discrete set of coded string values that are distinct.", + "output": "DSET (DataType)" + }, + { + "input": "Definition: Intellectual Product described as a terminology codelist for the test code of the test or examination used to obtain the measurement or finding of the device in use.", + "output": "Device-In-Use Test Code (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Zinc Compounds described as a salt produced by the reaction of zinc oxide with acetic acid and used as an astringent, styptic, and emetic.", + "output": "Dicarbomethoxyzinc (Dietary Supplements)" + }, + { + "input": "Definition: Gene or Genome described as regulatory genes which encode a cyclic AMP receptor protein required for L-arabinose utilization in E. coli. It is an example of positive control or regulation of gene expression in the bacterial operon.", + "output": "araC Gene (Gene or Genome)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable aqueous solution containing the chloride salt of the radioisotope calcium-46 (46Ca) with phosphate-binding and radioisotopic activities. Upon administration of calcium-46 chloride aqueous solution, calcium-46 is preferentially taken up by osteoblasts, which generate mineralized osteoid containing calcium. Calcium-46 accumulation and turnover in bone can be measured with bone scintigraphy and urinary isotope excretion testing.", + "output": "calcium-46 chloride aqueous solution (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of dacarbazine that may be used in the treatment of cutaneous melanoma; pancreatic neuroendocrine tumors (NETs); and soft tissue and uterine sarcomas.", + "output": "DTIC Regimen (Regimen Used to Treat Malignant Neuroendocrine and Adrenal Neoplasm)" + }, + { + "input": "Definition: Terminology Entity described as the terminology entities that represent the elements that form and define the NCI Thesaurus.", + "output": "NCI Thesaurus Entity (Idea or Concept)" + }, + { + "input": "Definition: something described as any organism, such as a virus, parasite, or bacterium, that is capable of invading body tissues and multiplying.", + "output": "infectious agent (General Etiologic Associations)" + }, + { + "input": "Definition: something described as a part of the pontine reticular formation and medullary reticular formation of the mouse ( Paxinos-2001, Hof-2000 ).", + "output": "Intermediate reticular nucleus (Nucleus of brain)" + }, + { + "input": "Definition: Physiologic Function described as any physiologic process which occurs in response to ligation of a colony stimulating factor receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell. This process is involved in regulating the extent of the response to receptor binding, and in regulating active populations of macrophages, granulocytes and myeloid cells.", + "output": "Negative Regulation of Colony Stimulating Factor Signaling (Physiologic Function)" + }, + { + "input": "Definition: something described as a drug used to treat depression and anxiety", + "output": "Lexapro (Pharmacologic Substance)" + }, + { + "input": "Definition: Chemical categorised functionally described as a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.", + "output": "N-Methylacetazolamide (Chemical categorised functionally)" + }, + { + "input": "Definition: Classification described as cancer that is localized in its original site of growth, or involves adjacent lymph nodes but has not spread to other anatomic sites.", + "output": "Limited stage (Classification)" + }, + { + "input": "Definition: Anatomy Qualifier described as situated outside of a capsule, esp. outside the capsular ligament of a joint.", + "output": "Extracapsular (Anatomy Qualifier)" + }, + { + "input": "Definition: something described as a space equiped and dedicated to the care of dental patients.", + "output": "Dental Operatory (Health care facility)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Naming task for fingers of the dominant hand, little finger or pinky.", + "output": "Naming Objects and Fingers: Pinky (Intellectual Product)" + }, + { + "input": "Definition: Psychosocial intervention strategy described as methods or procedures used to cope with excessive levels of stress.", + "output": "Stress Control (Behavior Modification & Therapy)" + }, + { + "input": "Definition: ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Constructional praxis task for copying a cube.", + "output": "Constructional Praxis: Cube (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: Hormone abnormality described as insufficient production of growth hormone.", + "output": "Somatotropin Deficiency (Hormone abnormality)" + }, + { + "input": "Definition: something described as SAM pointed domain-containing Ets transcription factor (335 aa, ~38 kDa) is encoded by the human SPDEF gene. This protein is involved in transcriptional regulation and may modulate both prostate development and prostate cancer progression.", + "output": "Prostate-Specific Ets (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as any viral organism that can be assigned to the Human Parainfluenza virus 3 serotype.", + "output": "Parainfluenza Virus 3, Human (Respirovirus)" + }, + { + "input": "Definition: something described as a microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease.", + "output": "KIT, IDENTIFICATION, YEAST (Medical Device)" + }, + { + "input": "Definition: Structure of teeth, gums, and supporting structures described as any of the teeth of the first dentition, which are usually shed and replaced by the permanent teeth.", + "output": "Dentition, Primary (Tooth structure)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion.", + "output": "negative regulation of interleukin-13 secretion (Cell Function)" + }, + { + "input": "Definition: something described as a province in the east of Canada, composed of Newfoundland Island and Labrador. Its capital is St. John's", + "output": "Newfoundland and Labrador (Province)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) (SGCA) gene, located at chromosome 17q21, which encodes for a member of a multisubunit protein complex necessary for the stability of muscle fiber membranes and to link the actin cytoskeleton to the extracellular matrix. This genetic mutation has been identified in patients with Duchenne-like muscular dystrophy type 2.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SGCA (Medical Device)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane.", + "output": "positive regulation of leucine import into cell (positive regulation of amino acid transport)" + }, + { + "input": "Definition: something described as a superficial landmark identified by dissection in the human insula. It represents the surfaces of the accessory insular gyrus and the transverse insular gyrus located at the most anteroinferior aspect of the anterior insula where it meets the frontal lobe ( Ture-1999 ). It is not found in the macaque or the rodent ( NeuroNames ).", + "output": "insular pole (Body Location or Region)" + }, + { + "input": "Definition: IL1RN gene described as human IL1RN wild-type allele is located in the vicinity of 2q14.2 and is approximately 27 kb in length. This allele, which encodes interleukin-1 receptor antagonist protein, plays a role in the regulation of interleukin-1-mediated signal transduction. Mutation or polymorphism of the gene is associated with susceptibility to microvascular complications of diabetes type 4, interleukin 1 receptor antagonist deficiency, increased risk of osteoporotic fractures and gastric cancer", + "output": "IRAP (IL1RN gene)" + }, + { + "input": "Definition: something described as forceps used to grasp, firmly hold, and exert traction or compression on the gallbladder during gallstone removal surgery.", + "output": "Forceps, Gallbladder (Forceps)" + }, + { + "input": "Definition: something described as a question about an individual's certainty that they can avoid smoking after a meal.", + "output": "Refrain from Smoking After a Meal (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as diseases involving the MAXILLA.", + "output": "Maxillary Disorders (Jaw Diseases)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.", + "output": "keratan sulfate catabolism (keratan sulfate metabolic process)" + }, + { + "input": "Definition: Oxygenators described as apparatus that provides mechanical circulatory support during open-heart surgery, by passing the heart to facilitate surgery on the organ. The basic function of the machine is to oxygenate the body's venous supply of blood and then pump it back into the arterial system. The machine also provides intracardiac suction, filtration, and temperature control. Some of the more important components of these machines include pumps, oxygenators, temperature regulators, and filters.", + "output": "heart lung machine (Oxygenators)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as toxicogenomics is a new scientific field that elucidates how the entire genome is involved in biological responses of organisms exposed to environmental toxicants/stressors. Toxicogenomics combines information from studies of genomic-scale mRNA profiling (by microarray analysis), cell-wide or tissue-wide protein profiling (proteomics), genetic susceptibility, and computational models to understand the roles of gene-environment interactions in disease.", + "output": "Toxicogenomics (Bio-Informatics)" + }, + { + "input": "Definition: Vital Statistics described as in epidemiology, a rating scale for comorbidity.", + "output": "Comorbidity Index (Quantitative Concept)" + }, + { + "input": "Definition: Plasmodium described as a protozoan parasite in the family Plasmodiidae. P. falciparum is transmitted by the female Anopheles mosquito and is a causative agent of malaria in humans. The malaria caused by this species is the most dangerous form of malaria.", + "output": "falciparums, Plasmodium (Plasmodium)" + }, + { + "input": "Definition: something described as using an automated device to measure and/or evaluate a client's ability to contract his or her muscle(s) and exert force at a controlled speed in a particular region of his or her body. Service is billed per test.", + "output": "isokntc tstng 1 rgn ea.tst (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Quantitative Concept described as deployed stent length, as marked on the packaging.", + "output": "Nominal Stent Length (Quantitative Concept)" + }, + { + "input": "Definition: Organic Chemical described as pine agaric.", + "output": "Polyporus pinicola / pine agaric (Organic Chemical)" + }, + { + "input": "Definition: Lymphoma, Non-Hodgkin described as non-Hodgkin lymphoma occuring in childhood. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7706\" active clinical trials using this agent.", + "output": "Non-Hodgkin Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O.", + "output": "17(E)-cheilanthenediol synthase activity (Molecular Function)" + }, + { + "input": "Definition: Functional Concept described as used with organs, animals, and higher plants and with diseases for microbiologic studies. For parasites, \"parasitology\" is used; for viruses, \"virology\" is used.", + "output": "MI (Functional Concept)" + }, + { + "input": "Definition: Internal medicine specialty described as branch of medicine dealing with the study of disorders affecting the stomach, intestines, and associated organs", + "output": "GASTROENTEROL (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Digestive System Disorders described as allergic reaction to peanuts that is triggered by the immune system.", + "output": "peanut allergies (Infectious disease due to plant)" + }, + { + "input": "Definition: Tissue integrity status described as wide in width, extent or cross-section.", + "output": "Thickness (General adjectival modifier)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had difficulty breathing when exposed to cold temperatures", + "output": "Have Difficulty Breathing When Exposed to Cold Temperatures (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 protein (336 aa, ~38 kDa) is encoded by the human ST6GALNAC5 gene. This protein plays a role in regulation of extracellular matrix biosynthesis.", + "output": "Sialyltransferase 7E (glycosyltransferase)" + }, + { + "input": "Definition: Lipids measurement described as a description of the low density lipoprotein particle pattern (an interpretation of the amounts of LDL particles based on size and density) in a sample.", + "output": "LDLPATT (Laboratory Procedure)" + }, + { + "input": "Definition: positive regulation of kidney development described as any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.", + "output": "positive regulation of glomerulus development (positive regulation of kidney development)" + }, + { + "input": "Definition: Central Nervous System described as accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.", + "output": "Plaque, Amyloid (Pathological Conditions, Anatomical)" + }, + { + "input": "Definition: Molecular Function described as a photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP.", + "output": "photosynthetic electron transport in photosystem I (Molecular Function)" + }, + { + "input": "Definition: Extent of removal described as the degree to which the lesion has been cut out, or resected.", + "output": "Extent of resection (Extent of removal)" + }, + { + "input": "Definition: something described as anabolic formation of blood lipoproteins.", + "output": "blood lipoprotein biosynthesis (Anabolism)" + }, + { + "input": "Definition: Lowered biochemistry finding described as an abnormally reduced amount of creatinine in the blood.", + "output": "Decreased serum creatinine (Serum creatinine abnormal)" + }, + { + "input": "Definition: something described as this class establishes the relationship between protection group and roles and becomes a member for a user and a group.", + "output": "Protection Group Role Context (UML Entity)" + }, + { + "input": "Definition: Argon and argon compound described as noble gas element with the atomic symbol Ar, atomic number 18, and atomic weight 39.948; used in fluorescent tubes and in other situations where an inert atmosphere is desired.", + "output": "Ar element (Noble Gases)" + }, + { + "input": "Definition: Male Reproductive System Finding described as a finding indicating the involvement of the testis by a malignant neoplasm.", + "output": "Testicular Involvement (Male Reproductive System Finding)" + }, + { + "input": "Definition: Chromosome 16 Physical Location described as physical location of ITGAL_Gene", + "output": "16: 30391572-30442007 (Spatial Concept)" + }, + { + "input": "Definition: Remote location new client without ICD diagnosis described as using homeopathic assessment methods in a comprehensive, 60-minute, out-of-office meeting to assess the health status of a new homeopathy client to develop a homeopathic treatment plan.", + "output": "new xofc 60min homeo ntak (Remote location new client without ICD diagnosis)" + }, + { + "input": "Definition: HER2/Neu Positive by Immunohistochemistry described as an immunohistochemical staining finding indicating that 61-70 percent of the cells in a tissue sample are expressing receptor tyrosine-protein kinase erbB-2.", + "output": "HER2/Neu Positive by Immunohistochemistry 61-70 Percent (HER2/Neu Positive by Immunohistochemistry)" + }, + { + "input": "Definition: anatomical structure formation involved in morphogenesis described as the process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "output": "medulla oblongata formation (Organism Function)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine.", + "output": "downregulation of methane biosynthetic process from dimethylamine (Molecular Function)" + }, + { + "input": "Definition: something described as ASSIGN Cardiovascular Disease 10-Year Risk Score (ASSIGN Score) Risk score.", + "output": "ASSG0101 (ASSIGN Score Clinical Classification Question)" + }, + { + "input": "Definition: something described as a stage during labor and childbirth that starts with the delivery of the placenta and lasts about two hours after delivering the baby.", + "output": "Fourth Stage of Labor (labor stage)" + }, + { + "input": "Definition: Organism Attribute described as any genetically determined characteristic.", + "output": "traits (Organism Attribute)" + }, + { + "input": "Definition: Sulfoxide described as a 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.", + "output": "Product containing lansoprazole (Proton Pump Inhibitors)" + }, + { + "input": "Definition: Urethral Cancer Pathologic TNM Finding v7 described as a pathologic finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.", + "output": "Urethral Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)" + }, + { + "input": "Definition: PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - During the last week, how happy has your child been with: His/her ability to do the same things his/her friends do?", + "output": "PODCI113 (PODCI Pediatric Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: something described as a primary or metastatic malignant neoplasm affecting the brain.", + "output": "Brain--Cancer (Korean Standard Classification of Disease Version 5)" + }, + { + "input": "Definition: something described as a species of zoophilic fungi in the phylum Ascomycota that causes ringworm in horses, but rare infections in humans.", + "output": "Trichophyton equinum (Trichophyton)" + }, + { + "input": "Definition: regulation of alpha-beta T cell activation described as any process that modulates the frequency, rate or extent of natural killer T cell activation.", + "output": "regulation of NK T cell activation (regulation of alpha-beta T cell activation)" + }, + { + "input": "Definition: Plant Physiological Processes described as the loss of water vapor by plants to the atmosphere. It occurs mainly from the leaves through pores (stomata) whose primary function is gas exchange. The water is replaced by a continuous column of water moving upwards from the roots within the xylem vessels.", + "output": "Plant Transpiration (Plant Physiological Processes)" + }, + { + "input": "Definition: Disease Treatment Qualifier described as unable to be removed with surgery.", + "output": "Non-Resectable (Disease Treatment Qualifier)" + }, + { + "input": "Definition: something described as interleukin-21 receptor protein (538 aa, ~59 kDa) is encoded by the human IL21R gene. This protein plays a role in both the cellular binding and the signaling cascade of interleukin-21.", + "output": "IL21R (Receptors, Cytokine)" + }, + { + "input": "Definition: Oils, Volatile described as a species of CITRUS that is much used as a tough rootstock for other CITRUS species. The fruit inhibits CYTOCHROME P-450 isoform 3A4 much like grapefruit (CITRUS PARADISI).", + "output": "Orange Trees, Bitter (Citrus plant)" + }, + { + "input": "Definition: something described as viral infections that may be transmitted between non-human animals and HUMANS.", + "output": "Zoonotic Viral Infection (Zoonoses)" + }, + { + "input": "Definition: something described as an abnormal form or location of a pulmonary fissure. []", + "output": "Abnormal pulmonary fissure architecture (Abnormal pulmonary fissure morphology)" + }, + { + "input": "Definition: steroid hormone receptor binding described as interacting selectively and non-covalently with an estrogen receptor.", + "output": "estrogen receptor binding (Molecular Function)" + }, + { + "input": "Definition: Congenital blepharophimosis described as an ophthalmic disorder characterised by blepharophimosis, ptosis, epicanthus inversus, and telecanthus that can appear associated with or without premature ovarian failure. The disorder is congenital. Additional features include lacrimal duct anomalies, broad nasal bridge, low-set ears, and a short philtrum. Occurs either sporadically (de novo) or, for the eyelid phenotype, is inherited in an autosomal dominant manner with complete penetrance.", + "output": "Blepharophimosis, ptosis, and epicanthus inversus syndrome (Female gonadal function disorders)" + }, + { + "input": "Definition: something described as CD83 antigen (205 aa, ~23 kDa) is encoded by the human CD83 gene. This protein may play a role in antigen presentation.", + "output": "CD83 Antigen (Immunologic Factor)" + }, + { + "input": "Definition: Angiokeratoma of Fordyce described as an angiokeratoma that is located on the scrotum.", + "output": "Fordyce angiokeratoma of scrotum (Scrotal disorders NEC)" + }, + { + "input": "Definition: Neoplastic Process described as primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment.", + "output": "Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma (Refractory Primary Vitreoretinal Lymphoma)" + }, + { + "input": "Definition: Xenopodinae described as aquatic amphibian genus of the family Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.", + "output": "Xenopus (Amphibian)" + }, + { + "input": "Definition: something described as the date and time span for when the study country personnel is active. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Study Country Personnel Effective Date Range (Temporal Concept)" + }, + { + "input": "Definition: suppression by symbiont of host signal transduction pathway described as any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway (suppression of host defenses by symbiont)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 (NCCN-FACT FBRSI-24 V2) (Copyright 1987, 1997 David Cella, Ph.D. All Rights Reserved; Questionnaires and all related subscales, translations, and adaptations ('FACIT System') are owned and copyrighted by David Cella, Ph.D. The ownership and copyright of the FACIT System resides strictly with Dr. Cella. Dr. Cella has granted FACIT.org the right to license usage of the FACIT System to other parties).", + "output": "National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 Questionnaire (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the side of the body (or a paired organ) that is a target site for an observation. EXAMPLE(S): bilateral, left, right", + "output": "Defined Observation Target Anatomic Site Laterality Code (Target Anatomic Site Laterality Code)" + }, + { + "input": "Definition: something described as the determination of the number of malignant cells present in a sample.", + "output": "Malignant Cell Count (Cell Count)" + }, + { + "input": "Definition: Ventricular arrhythmias and cardiac arrest described as an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate less than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology.", + "output": "idioventricular rhythms (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human KRIT1 wild-type allele is located within 7q21-q22 and is approximately 102 kb in length. This allele, which encodes Krev interaction trapped protein 1, may play a role in integrin signaling modulation. Mutations in the gene, which encode for products that terminate prematurely, are a factor in familial cerebral cavernous malformations.", + "output": "CAM (Gene or Genome)" + }, + { + "input": "Definition: Genes, Homeobox described as this gene is involved in transcriptional regulation and development.", + "output": "NK2, DROSOPHILA, HOMOLOG OF, 8 (Genes, Homeobox)" + }, + { + "input": "Definition: Intellectual Product described as a standardized rating scale developed by Rappaport et al in 1982, which is used to track recovery of an individual from coma to community and to capture functional changes over the course of recovery for individuals with moderate to severe TBI. The survivor version of this instrument has 26 items.", + "output": "EXPANDED DRS-PI SURVIVOR VERSION (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Speculum described as specula designed to expand the anal canal, rectum, and/or sigmoid colon. These specula typically consist of either a hollow, funnel-like device or a mechanical instrument that frequently includes two pivoted arms. The portions closer to the pivot point are usually the handle, while the distal portions are inserted through the anal canal into the rectum. Specula may be used directly to perform examinations and manual procedures or as part of an anoscope, proctoscope, or sigmoidoscope for examination or surgery (e.g., hemorrhoid treatment). Both disposable (e.g., plastic) and reusable rectal specula are available in different sizes and shapes; some include a lighting system.", + "output": "Specula, Rectal (Speculum)" + }, + { + "input": "Definition: Finding described as reduction in growth velocity of >=50% ideally measured over the period of a year", + "output": "Grade 3 Growth Suppression, CTCAE (Finding)" + }, + { + "input": "Definition: Fetal heart finding described as the sequence of a fetal heart rhythm and rate.", + "output": "Fetal Heart Rate Pattern (Fetal heart finding)" + }, + { + "input": "Definition: biomedical tube device described as a tube with a narrow diameter designed to hold a liquid by capillary action.", + "output": "Capillary Tube Device (biomedical tube device)" + }, + { + "input": "Definition: CDISC Functional Test Terminology described as test names of functional test questions associated with the Timed 25-Foot Walk Test (T25FW) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).", + "output": "FT- T25FW TEST (Intellectual Product)" + }, + { + "input": "Definition: something described as medicinal product consisting of prolonged-release granules presented in a sachet.", + "output": "Prolonged-Release Granules in Sachet (Biomedical or Dental Material)" + }, + { + "input": "Definition: Procedure categorized by device involved described as a form of therapy consisting in the local or general use of cold. The selective destruction of tissue by extreme cold or freezing is CRYOSURGERY.", + "output": "Cryotherapies (Clinical actions A - G)" + }, + { + "input": "Definition: Cell Component described as any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.", + "output": "Mitochondrial crista (MITOCHONDRION AND ASSOCIATED STRUCTURES)" + }, + { + "input": "Definition: something described as the known quantity of intake in one day of a polyunsaturated, omega 3 fatty acid with a 20-carbon chain and five cis double bonds.", + "output": "Measured intake of eicosapentaenoic acid in 24 hours (Quantitative Concept)" + }, + { + "input": "Definition: Renal Colic, CTCAE described as mild pain not interfering with activity; nonprescription medication indicated", + "output": "Grade 1 Renal colic (Renal Colic, CTCAE)" + }, + { + "input": "Definition: neutral amino acid transport described as the directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "homoserine transport (neutral amino acid transport)" + }, + { + "input": "Definition: something described as tumor protein 63 isoform 2 (586 aa, ~66 kDa) is encoded by the human TP63 gene. This protein plays a role in the mediation of both transcription and skin development.", + "output": "Delta-N p63-Alpha (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Finding described as shortening of the middle parts of the arm in relation to the upper and terminal segments.", + "output": "Upper limb brachymesomelia (Mesomelia)" + }, + { + "input": "Definition: Finding described as problem with image display leading to corrupted images or readouts/measurement indications.", + "output": "Image Display Error/Artifact (Display or Visual Feedback Problem)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an enzyme that catalyzes the demethylation of L-homocysteine to L-METHIONINE.", + "output": "S Methylmethionine Homocysteine Methyltransferase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Neoplastic Process described as stage II Merkel cell carcinoma is divided into stages IIA, IIB, and IIC. In stage IIA, the tumor is larger than 2 centimeters and no cancer is found when the lymph nodes are checked under a microscope. In stage IIB, the tumor is larger than 2 centimeters and no swollen lymph nodes are found by a physical exam or imaging tests. In stage IIC, the tumor may be any size and has spread to nearby bone, muscle, connective tissue, or cartilage. It is has not spread to lymph nodes or distant parts of the body.", + "output": "Stage II Merkel Cell Cancer (Merkel Cell Carcinoma by AJCC v7 Stage)" + }, + { + "input": "Definition: Ovarian Dermoid Cyst with Secondary Tumor described as a secondary carcinoma that has developed in an ovarian dermoid cyst. In the majority of cases, the secondary carcinoma is a squamous cell carcinoma.", + "output": "Ovarian Dermoid Cyst with Secondary Carcinoma (Ovarian Dermoid Cyst with Secondary Tumor)" + }, + { + "input": "Definition: Diagnostic Procedure described as an assessment of the internal soft tissue structures.", + "output": "VISCEXAM (Diagnostic Procedure)" + }, + { + "input": "Definition: Molecular Genetics described as any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.", + "output": "DNA Recombination (DNA metabolic process)" + }, + { + "input": "Definition: Finding described as a way to indicate that the infant has had no feeds of any kind", + "output": "None (Finding)" + }, + { + "input": "Definition: something described as a preparation of autologous CD8-positive T-lymphocytes that have been genetically modified via transient mRNA transfection to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-mRNA transfected CD8+ T-lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.", + "output": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-cells (Cell)" + }, + { + "input": "Definition: something described as a sinus bradycardia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.", + "output": "Grade 4 Neonatal Sinus Bradycardia, Adverse Event (Neonatal Sinus Bradycardia, Adverse Event)" + }, + { + "input": "Definition: something described as hours times milligrams per milliliter, divided by meters squared.", + "output": "h*mg/mL/m2 (Quantitative Concept)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - I feel close to my partner (or the person who is my main support).", + "output": "FACT-BMT Version 4 - I Feel Close to My Partner (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as a fetal ultrasonic monitor is a device designed to transmit and receive ultrasonic energy into and from the pregnant woman, usually by means of continuous wave (doppler) echoscopy. The device is used to represent some physiological condition or characteristic in a measured value over a period of time (e.g., perinatal monitoring during labor) or in an immediately perceptible form (e.g., use of the ultrasonic stethoscope). This generic type of device may include the following accessories: signal analysis and display equipment, electronic interfaces for other equipment, patient and equipment supports, and component parts. This generic type of device does not include devices used to image some relatively unchanging physiological structure or interpret a physiological condition, but does include devices which may be set to alarm automatically at a predetermined threshold value.", + "output": "Ultrasonic Blood-Flow Detectors (Detectors, Blood Flow)" + }, + { + "input": "Definition: Proteinase inhibitors, antifibrinolytic described as a multivalent Kunitz-type serine protease inhibitor derived from human urine, with potential protective, anti-fibrinolytic and anticoagulant activities. Upon administration, ulinastatin (or urinary trypsinogen inhibitor) inhibits the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. In addition, ulinastatin inhibits the excessive release of proinflammatory mediators, such as tumor necrosis factor-alpha, interleukin-6 and -8, and chemokines. Altogether, this agent may improve the microcirculation, perfusion and function of tissues and may protect organ injury. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102851\" active clinical trials using this agent.", + "output": "urinary trypsin inhibitor-like inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: Neoplastic Process described as primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.", + "output": "Tumors, Supratentorial (Neoplastic Process)" + }, + { + "input": "Definition: something described as a score of 18 on the COXEN Sensitivity Scale.", + "output": "COXEN Score 18 (Finding)" + }, + { + "input": "Definition: 2-methylbutanoyl-CoA(4-) metabolic process described as the chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-).", + "output": "2-methylbutanoyl-CoA(4-) breakdown (fatty-acyl-CoA catabolic process)" + }, + { + "input": "Definition: something described as a question about the degree to which an individual feels forgetful right now.", + "output": "How Forgetful at Present (Intellectual Product)" + }, + { + "input": "Definition: MYC Family Genes described as this gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.", + "output": "MYC-RELATED GENE FROM LUNG CANCER (MYC Family Genes)" + }, + { + "input": "Definition: Finding described as retinoblastoma with tumor superficially invading optic nerve head but not extending past lamina cribrosa or tumor exhibiting focal choroidal invasion.", + "output": "Retinoblastoma pT2a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Keratoderma, Palmoplantar, Diffuse described as a hereditary syndrome this is characterized by palmoplantar keratoderma accompanied by leukoplakia and may be associated with a high lifetime risk of esophageal cancer, as seen in Howel-Evans Syndrome.", + "output": "Palmoplan keratoderm+leukoplak (Keratoderma, Palmoplantar, Diffuse)" + }, + { + "input": "Definition: Gastrointestinal Disorders, CTCAE described as a disorder characterized by a rupture in the stomach wall.", + "output": "Gastric Perforation (Gastrointestinal Disorders, CTCAE)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as autosomal recessive spastic paraplegia type 66 is a rare, complex hereditary spastic paraplegia disorder with characteristics of infantile onset of progressive lower limb spasticity, severe gait disturbances leading to a non-ambulatory state, absent deep tendon reflexes and amyotrophy. Additional signs include severe sensorimotor neuropathy, pes equinovarus and mild intellectual disability. Cerebellar and corpus callosum hypoplasia, as well as colpocephaly, are observed on neuroimaging.", + "output": "Autosomal recessive spastic paraplegia type 66 (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in DNA transposition.", + "output": "CGIN1 (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: Heart valve disease described as downward displacement of any one of the HEART VALVES from its normal position. This usually results in failed valve closure.", + "output": "Heart Valve Prolapses (Disease or Syndrome)" + }, + { + "input": "Definition: Human Activities described as group activities directed against VACCINATION.", + "output": "Anti-Vaccination Movement (Human Activities)" + }, + { + "input": "Definition: something described as test codes of questionnaire questions associated with the Patient Health Questionnaire - 2 Item (PHQ-2) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "PHQ04TC (Intellectual Product)" + }, + { + "input": "Definition: steroid hormone receptor binding described as interacting selectively and non-covalently with an androgen receptor.", + "output": "AR binding (Molecular Function)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a mutation occurring within the start codon of a gene that results in a sequence that no longer encodes a start codon. This can result in a gene deletion or gene transcription may start from an alternative start site.", + "output": "Start Lost (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Child developmental detail described as use of activities by a child to foster age-appropriate social and physical skills that are enjoyable and entertaining", + "output": "Play behavior (Child developmental detail)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid preparation consisting of one or more powders intended to be dispersed in the specified liquid to obtain an oral drops suspension.", + "output": "Oral Drops, Powder for Suspension Dosage Form (Oral Dosage Form)" + }, + { + "input": "Definition: Regulatory Protein described as sperm protein associated with the nucleus on the X chromosome N3 (141 aa, ~16 kDa) is encoded by the human SPANXN3 gene. This protein may be involved in spermatid development.", + "output": "SPANX Family Member N3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the disposition to develop an allergic or pseudoallergic reaction.", + "output": "Hypersensitivity disposition (Pathologic Function)" + }, + { + "input": "Definition: Intellectual Product described as paced Tapping Test (Paced Tapping) The median intertap interval within the tone-tapping phase of Trial n (in milliseconds).", + "output": "Paced Tapping - Median Interval Tone Trial (Paced Tapping Functional Test Question)" + }, + { + "input": "Definition: camera-type eye photoreceptor cell fate commitment described as the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye.", + "output": "retinal rod cell fate commitment (camera-type eye photoreceptor cell fate commitment)" + }, + { + "input": "Definition: Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7 described as stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).", + "output": "stage IIIA mycosis fungoides/Sezary syndrome (Neoplastic Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cancer vaccine containing an HLA-A*0201-restricted vascular endothelial growth factor receptor 1 (VEGFR1) peptide (sequence: TLFWLLLTL) with potential immunostimulatory and antitumor activities. Upon administration, HLA-A*0201-restricted VEGFR1-derived peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing VEGFR1, resulting in tumor cell lysis and decreased tumor growth. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity.", + "output": "HLA-A*0201-Restricted VEGFR1 Peptide Vaccine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a proprietary orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Aminopeptidase inhibitor CHR-2797 is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death. Noxa is a member of the BH3 (Bcl-2 homology 3)-only subgroup of the proapoptotic Bcl-2 (B-cell CLL/lymphoma 2) protein family.", + "output": "Cyclopentyl (2S)-2-{(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4- methylpentanamido}-2-phenylacetate (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Skin AND/OR mucosa finding described as formation of an epidermal layer which lacks nuclei during normal keratinisation.", + "output": "Orthokeratosis (Keratosis)" + }, + { + "input": "Definition: regulation of sulfur metabolic process described as any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly.", + "output": "regulation of iron-sulfur cluster assembly (Molecular Function)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the lipocalin-2 to creatinine present in a sample.", + "output": "LCN2CREA (Urine protein test)" + }, + { + "input": "Definition: something described as analgesic delivery into the spinal axis.", + "output": "Neuraxial Opioid Analgesia (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: negative regulation of developmental process described as any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.", + "output": "negative regulation of vasculature development (regulation of vasculature development)" + }, + { + "input": "Definition: something described as positive and Negative Syndrome Scale (PANSS) Temperature - Anxiety.", + "output": "PANSS1-Anxiety (PANSS Clinical Classification Question)" + }, + { + "input": "Definition: Lipid Metabolism Pathway described as phosphoglycerides are lipids that contain glycerol with a phosphate ester on one end and two fatty acid ester side chains. Phosphoglycerides such as phosphatidylethanolamine and phosphatidylserine are the major component of lipid bilayer membranes in which their detergent-like properties help to provide membranes the quality of self-assembly. Phosphatidylglycerol is a phospholipid in which the phosphate ester on glycerol is joined to another glycerol. Phosphatidylglycerol is a precursor in the synthesis of both cardiolipin and phosphatidylinositol. In cardiolipin, two phosphatidylglycerol units are joined together. Cardiolipin was first identified in the heart, thus its name, and is abundant in the heart. Antibodies against cardiolipin have been observed in the blood of individuals with autoimmune disorders such as lupus. In mammals, cardiolipin is localized in mitochondria and may play a role in oxidative phosphorylation. Changes in cardiolipin levels with age might alter mitochondrial function and contribute to the aging process. Another derivative of phosphatidylglycerol is phosphatidylinositol in which the sugar inositol forms the phosphate ester. Inositol is an important intermediary in intracellular signaling pathways. Esterification of inositol with phosphates at various positions alters its interaction with different signaling proteins. Phosphatidylinositol can be phosphorylated at two positions to create PIP2. Hydrolysis of PIP2 by phospholipase C in response to GPCR activation releases IP3, which acts as a cytoplasmic second messenger to stimulate calcium release.", + "output": "Synthesis of Cardiolipin and Phosphatidylinositol Pathway (Lipid Metabolism Pathway)" + }, + { + "input": "Definition: something described as a medical image hardcopy device is a device that produces a visible printed record of a medical image and associated identification information. Examples include multiformat cameras and laser printers.", + "output": "Cameras, Photographic, Multi-Image (Diagnostic imaging equipment)" + }, + { + "input": "Definition: General Disorders and Administration Site Conditions, CTCAE described as an unexpected death that cannot be attributed to a CTCAE term associated with Grade 5.", + "output": "Sudden death NOS (General Disorders and Administration Site Conditions, CTCAE)" + }, + { + "input": "Definition: Multiple system malformation syndrome described as syndrome that may be classified among the neurocutaneous syndromes, associates abnormalities of the cerebellum (rhombencephalosynapsis), cranial nerves (trigeminal anaesthesia), and scalp (alopecia). It has been reported in 11 individuals so far. Other features observed in patients were craniosynostosis, midfacial hypoplasia, bilateral corneal opacities, low-set ears, short stature, moderate intellectual impairment and ataxia. Hyperactivity, depression, self-injurious behaviour and bipolar disorder have also been reported.", + "output": "Gomez Lopez Hernandez syndrome (Neurocutaneous Syndromes)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of radioactivity equal to one millionth of a Curie or 37 kilobecquerels, and corresponding to a radioactivity of 37 000 atomic disintegrations per second.", + "output": "uCi (Non-SI unit of radionuclide source activity)" + }, + { + "input": "Definition: something described as a mid-to-late diastolic murmur heard best at the cardiac apex, heard in cases of aortic insufficiency", + "output": "Austin-Flint murmur (Conduction disorder of the heart)" + }, + { + "input": "Definition: Armadillo Domain Proteins described as members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.", + "output": "Plakophilins (Biologically Active Substance)" + }, + { + "input": "Definition: Organic Chemical described as an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.", + "output": "OLOPATADINE HYDROCHLORIDE (Histamine H1 Antagonists)" + }, + { + "input": "Definition: something described as the study of the similarities and differences between different living organisms of the process by which normal cells are transformed into cancer cells.", + "output": "Comparative Carcinogenesis (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: positive regulation of antimicrobial peptide secretion described as any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion.", + "output": "upregulation of antibacterial peptide secretion (Cell Function)" + }, + { + "input": "Definition: Mononegavirales Infections described as an encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.", + "output": "Near eastern equine encephalomyelitis (DISEASES DUE TO UNCLASSIFIED VIRUSES)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Suicidal behavior was present during the assessment period? (Prior to Study Entry).", + "output": "C-SSRS Already Enrolled Subjects - Suicidal Behavior (Intellectual Product)" + }, + { + "input": "Definition: Hypermagnesemia Severity described as cessation of cardiac function.", + "output": "Cardiac standstill (Cardiac Arrest)" + }, + { + "input": "Definition: Enzyme described as the class of all enzymes catalyzing oxidoreduction reactions (EC class 1). The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor: acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor.", + "output": "EC 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: artery morphogenesis described as the process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.", + "output": "pharyngeal arch artery morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: Organic Chemical described as a small molecule and prodrug of CWP232204 targeting Src associated in mitosis, of 68 kDa (Sam68 or KHDRBS1), with potential antineoplastic activity. CWP232291 is converted in serum into its active form CWP232204 which binds to Sam68, thereby resulting in the induction of apoptosis in selective cancer cells. Due to the multimodular structure of Sam68, the apoptosis mediated by CWP232204-Sam68 interaction can be attributed to 1) activation of transcription factor NF-kB induced by tumor necrosis factor alpha signaling, 2) alternative splicing of BCL-2 apoptosis gene, driving the balance towards pro-apoptotic as opposed to anti-apoptotic isoforms, 3) down-regulation of the anti-apoptotic protein survivin via Want signaling. Sam68, a KH domain RNA-binding protein belonging to the signal transduction and activation of RNA (STAR) family, plays a key role in various cellular processes including cell cycle progression and apoptosis; it is upregulated in many types of cancer cells and its expression is associated with increased cell proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97663\" active clinical trials using this agent.", + "output": "CWP232291 (Pharmacologic Substance)" + }, + { + "input": "Definition: Transcription Regulatory Protein described as elongin-C (112 aa, ~12 kDa) is encoded by the human ELOC gene. This protein plays a role in the positive regulation of transcriptional elongation.", + "output": "Elongin 15 kDa Subunit (Biologically Active Substance)" + }, + { + "input": "Definition: something described as antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.", + "output": "isoantigen (Immunologic Factor)" + }, + { + "input": "Definition: Medical Device described as multimodal assay reagents intended to assess variation in chromosomal anomalies (e.g., copy number variants) and gene anomalies (e.g., mutations) in specific genes by DNA sequence analysis. These multimodal assays incorporate the results of these separate tests into a predetermined algorithm that produces a score intended to aid clinicians in determining disease diagnosis, prognosis, and/or treatment options.", + "output": "IVD Test Reagent/Kits, Multimodal Assay, Chromosome Anomaly/Gene Anomaly (IVD Test Reagent/Kits, Multimodal Assay)" + }, + { + "input": "Definition: Chondrogenic Neoplasm described as multiple formation of chondromas.", + "output": "chondromatosis (Chondrogenic Neoplasm)" + }, + { + "input": "Definition: Congenital hemolytic uremic syndrome described as haemolytic uraemic syndrome with either a family history of haemolytic uraemic syndrome or a genetic mutation known to cause haemolytic uraemic syndrome, or both.", + "output": "Familial haemolytic uraemic syndrome (Familial disease)" + }, + { + "input": "Definition: something described as the eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.", + "output": "eIF-4F (protein-containing complex)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation.", + "output": "regulation of T-helper 17 cell extravasation (Cell Function)" + }, + { + "input": "Definition: something described as uptake of substances by the body, tissues, or cells. The uptake may occur by various forms of BIOLOGICAL TRANSPORT or by simple DIFFUSION.", + "output": "Absorption, Physiological (Organism Attribute)" + }, + { + "input": "Definition: Adenocarcinoma described as an adenocarcinoma arising from the stomach glandular epithelium. Gastric adenocarcinoma is primarily a disease of older individuals, most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter Pylori infection. The lack of early symptoms often delays the diagnosis of gastric cancer. The majority of patients present with advanced tumors which have poor rates of curability. Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type. The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a \"curative\" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4004\" active clinical trials using this agent.", + "output": "GASTRIC CANCER ADENOCARCINOMA (Gastric neoplasms malignant)" + }, + { + "input": "Definition: something described as the exposure to potentially harmful chemical, physical, or biological agents by inhaling them.", + "output": "Exposures, Inhalation (Environmental Exposure)" + }, + { + "input": "Definition: something described as ras-related protein Rab-44 (1021 aa, ~111 kDa) is encoded by the human RAB44 gene. This protein is involved in signaling and neutrophil degranulation.", + "output": "RAB44 (Enzyme)" + }, + { + "input": "Definition: something described as a friendly, inquisitive, lovable, compact exterminator breed. The coat is smooth and short, and may be a variety of pied colors. The average height range is 10-18 inches and the average weight range is 10-25 pounds.", + "output": "Rat Terrier (Non-Sporting Breed)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.", + "output": "positive regulation of ovulation (Biologic Function)" + }, + { + "input": "Definition: Reproductive System and Breast Disorders, CTCAE described as a disorder characterized by the abnormal absence of menses for at least three consecutive menstrual cycles", + "output": "Amenorrhea (Reproductive System and Breast Disorders, CTCAE)" + }, + { + "input": "Definition: something described as a substance being studied in the treatment of cancer. It blocks signals between growing cells and may kill cancer cells. It is a type of signal transduction inhibitor.", + "output": "Notch signaling pathway inhibitor MK0752 (Pharmacologic Substance)" + }, + { + "input": "Definition: Primary malignant neoplasm of palate described as a Kaposi sarcoma arising from the palate.", + "output": "ORAL KAPOSI SARCOMA (sarcoma of oral cavity)" + }, + { + "input": "Definition: Gene or Genome described as human HRAS wild-type allele is located in the vicinity of 11p15.5 and is approximately 3 kb in length. This allele, which encodes GTPase HRas protein, is involved in cellular mitogenesis. Mutations of HRAS are implicated in Costello syndrome, bladder cancer and oral squamous cell carcinoma.", + "output": "RAS Gene (Gene or Genome)" + }, + { + "input": "Definition: Biospecimen Type described as the type of a material sample taken from a biological entity for pharmacokinetic parameter testing.", + "output": "Pharmacokinetic Parameter Specimen Type (Qualitative Concept)" + }, + { + "input": "Definition: Organism Forms described as organisms whose GENOME has been changed by a GENETIC ENGINEERING technique.", + "output": "GMO (Organism)" + }, + { + "input": "Definition: something described as the maximum excretion rate divided by the surface area.", + "output": "Max Excretion Rate Norm by SA (Maximum Observed Excretion Rate)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Defactinib inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation, survival, and tumor angiogenesis. The tyrosine kinase FAK, a signal transducer for integrins, is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C79809\" active clinical trials using this agent.", + "output": "defactinib (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a creole language spoken as an official language of the Central African Republic.", + "output": "SAG (Language spoken)" + }, + { + "input": "Definition: Tooth finding described as the failure to retain teeth as a result of disease or injury.", + "output": "Tooth loss (Tooth finding)" + }, + { + "input": "Definition: Neuroanatomy described as the long ascending sensory pathways located lateral to the reticular formation of the brainstem. They include the medial lemniscus of the midbrain, the medial lemniscus of the pons, the medial lemniscus of the medulla, the lateral lemniscus, the spinothalamic tract, the dorsal trigeminal tract, the ventral trigeminal tract and the spinal trigeminal tract ( Carpenter-1983 ).", + "output": "lemniscal system (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Trichostrongylus described as any nematode parasite that can be assigned to the species Trichostrongylus vitrinus.", + "output": "Trichostrongylus vitrinus (Trichostrongylus)" + }, + { + "input": "Definition: something described as a tangent screen (campimeter) is a battery-powered device that is a large square cloth chart with a central mark of fixation intended to map on a flat surface the central thirty degrees of a patient's visual field. This generic type of device includes projection tangent screens, target tangent screens and targets, felt tangent screens, and battery-powered stereo campimeters.", + "output": "SCREEN, TANGENT, FELT (Medical Device)" + }, + { + "input": "Definition: Cathepsins described as a carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.", + "output": "Serine Carboxypeptidase I (Cathepsins)" + }, + { + "input": "Definition: Pseudomonadales described as genus of gram negative, aerobic, rod shaped bacteria widely distributed in nature; some species are pathogenic for humans, animals, and plants.", + "output": "Chryseomonas Holmes et al. 1986 (Pseudomonas)" + }, + { + "input": "Definition: White matter of medulla oblongata described as a neural tract which connects the TECTUM MESENCEPHALI and the SPINAL CORD and is involved in head and eye movement coordination.", + "output": "Fiber, Tectospinal (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Skin Physiological Phenomena described as the degree to which the skin can conduct electricity.", + "output": "skin conductance (Skin Physiological Phenomena)" + }, + { + "input": "Definition: Peptoniphilaceae described as a genus of anaerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Clostridiales XI.", + "output": "Peptoniphilus (Bacterium)" + }, + { + "input": "Definition: something described as liquid, usually multidose preparation consisting of a suspension intended for application to the external auditory meatus by spraying to obtain a local effect. Ear sprays are presented in containers with a spray pump or in pressurised containers fitted with a spray valve.", + "output": "Otic spray suspension (Biomedical or Dental Material)" + }, + { + "input": "Definition: Vaginal Dosage Form described as a ring composed of active and/or inert ingredient(s), intended for administration in or around the vagina.", + "output": "vaginal rings (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as the growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule.", + "output": "cell growth involved in Malpighian tubule morphogenesis (Cell Function)" + }, + { + "input": "Definition: Organism Function described as any process that activates or increases the frequency, rate, or extent of interleukin-25 production.", + "output": "positive regulation of interleukin-25 production (Organism Function)" + }, + { + "input": "Definition: something described as a preparation of allogeneic, organ donor-derived CD34-positive hematopoietic stem and progenitor cells (HPCs) and CD3-positive T-cells that can be used after organ transplantation to potentially prevent organ rejection. Upon infusion of the organ donor-derived CD34+ HPCs plus CD3+ T-cells MDR-101 after organ transplantation, these cells mix and co-exist with the recipient's blood and immune cells, thereby inducing hematologic mixed chimerism and enabling the recipient's immune system to become immune tolerant to the donor cells. This increases acceptance of the transplanted organ, decreases the risk of organ transplant rejection, increases organ survival and may decrease the need for additional immunosuppressive agents. The cells in MDR-101 are ex vivo processed in a specific and unique way which has yet to be fully elucidated. Cell doses are dependent on the degree of human leukocyte antigen (HLA)-match/HLA-mismatch between the recipient and donor.", + "output": "donor-derived CD34+ HPCs/CD3+ T cells MDR-101 (Cell)" + }, + { + "input": "Definition: Population Group described as subgroups of AIDS patients.", + "output": "AIDS Population (Population Group)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.", + "output": "pyrimidine nucleoside diphosphate biosynthetic process (nucleoside diphosphate biosynthetic process)" + }, + { + "input": "Definition: Abnormality of the middle phalanx of the 5th finger described as triangular shaped middle phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.", + "output": "Triangular shaped middle pinkie finger bone (Anatomical Abnormality)" + }, + { + "input": "Definition: Testicular hypogonadism described as an abnormality of XY sexual development characterized by the absence of both testes at birth.", + "output": "Congenital anorchia syndrome (Male gonadal function disorders)" + }, + { + "input": "Definition: Persons described as someone from whom tissue is removed for transplantation or other purpose.", + "output": "tissue donor (Population Group)" + }, + { + "input": "Definition: something described as general purpose laboratory equipment labeled or promoted for a specific medical use is a device that is intended to prepare or examine specimens from the human body and that is labeled or promoted for a specific medical use.", + "output": "Dialyzer, each (dialysis supplies)" + }, + { + "input": "Definition: something described as a cell or tissue processing facility that is located within a hospital.", + "output": "Hospital Based Cell or Tissue Processing Facility (Health care facility)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of Human Immunodeficiency Virus present in a sample.", + "output": "Human Immunodeficiency Virus (Laboratory Procedure)" + }, + { + "input": "Definition: Quantitative Concept described as a measurement of the amount of chloride being excreted in a biological specimen over a defined period of time (e.g. one hour).", + "output": "Chloride Excretion Rate (Excretion Rate)" + }, + { + "input": "Definition: something described as a state in the Southeast Region of Brazil. Its capital is Vitoria.", + "output": "Espirito Santo (Geographic Area)" + }, + { + "input": "Definition: Aplasia Cutis Congenita described as an extremely rare association syndrome, described in only two brothers to date (one of which died at 2 months of age), characterized by aplasia cutis congenita of the vertex and generalized edema (as well as hypoproteinemia and lymphopenia) due to intestinal lymphangiectasia. There have been no further descriptions in the literature since 1985.", + "output": "Aplasia cutis congenita with intestinal lymphangiectasia syndrome (Lymphatic Abnormalities)" + }, + { + "input": "Definition: Sick Sinus Syndrome, CTCAE described as symptomatic, intervention not indicated; change in medication initiated", + "output": "Grade 2 Sick Sinus Syndrome (Sick Sinus Syndrome, CTCAE)" + }, + { + "input": "Definition: Finding described as changes from the previous physical examination that are noted during the current physical examination.", + "output": "Change Since Last Physical Examination (Changing)" + }, + { + "input": "Definition: Intrahepatic Cholangiocarcinoma described as a mucinous cystic neoplasm that arises from the intrahepatic bile ducts and it is associated with an invasive carcinomatous component.", + "output": "cystadenocarcinoma of intrahepatic bile duct (Intrahepatic Cholangiocarcinoma)" + }, + { + "input": "Definition: Bacterium described as a taxonomic family of Gram negative, generally motile bacterium in the phylum Proteobacteria that includes the genera Pseudomonas and Rhizobacter, among others.", + "output": "FAMILY PSEUDOMONADACEAE (Bacteria)" + }, + { + "input": "Definition: Ileal Obstruction, CTCAE described as hospitalization indicated; invasive intervention indicated; limiting self care ADL; long intestinal tube indicated", + "output": "Grade 3 Ileum obstruction (Ileal Obstruction, CTCAE)" + }, + { + "input": "Definition: FACT-Taxane Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Taxane Version 4 (FACT-Taxane Version 4) Additional Concerns: I feel discomfort in my hands.", + "output": "FAC063-I Feel Discomfort in My Hands (FACT-Taxane Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Epilepsy described as a group of genetically-determined conditions characterized by a wide spectrum of seizure types occurring in otherwise healthy newborn infants that start during the first week of life and spontaneously disappear between the first and twelfth months of life.", + "output": "Benign Familial Convulsion (Epilepsy)" + }, + { + "input": "Definition: Pharmacologic Substance described as camomile.", + "output": "camomile (Flower Essences)" + }, + { + "input": "Definition: Carbohydrate Dehydrogenases described as d-Galactose:NAD(P)+ 1-oxidoreductases. Catalyzes the oxidation of D-galactose in the presence of NAD+ or NADP+ to D-galactono-gamma-lactone and NADH or NADPH. Includes EC 1.1.1.48 and EC 1.1.1.120.", + "output": "Galactose Dehydrogenases (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.", + "output": "T-tubule organisation (Cell Function)" + }, + { + "input": "Definition: Mass of upper limb described as an abnormal growth in the axilla.", + "output": "axillary lump (Mass of upper limb)" + }, + { + "input": "Definition: something described as a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES).", + "output": "MEPOLIZUMAB (Interleukin-5 Antagonist)" + }, + { + "input": "Definition: something described as a technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.", + "output": "THER BORON NEUTRON CAPTURE (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as putting something to a special use or purpose.", + "output": "Apply (Action)" + }, + { + "input": "Definition: regulation of ergot alkaloid biosynthetic process described as any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process.", + "output": "regulation of fumigaclavine C formation (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a 30-item questionnaire about patient ability to function, symptoms related to the cancer and its treatment, overall health and quality of life, and perceived financial impact of cancer and its treatment.", + "output": "The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (Intellectual Product)" + }, + { + "input": "Definition: something described as a process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism.", + "output": "envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism (Biologic Function)" + }, + { + "input": "Definition: something described as allogeneic tri-viral specific, adenovirus, cytomegalovirus and Epstein-Barr virus (Adv, CMV and EBV or ACE), cytotoxic T-lymphocytes (CTLs) with potential antiviral activity. Donor-derived T-cells were exposed to dendritic cells nucelofected with DNA plasmids encoding Hexon and Penton (Adv), pp65 and IE1 (CMV), and LMP2, EBNA1 and BZLF1 (EBV), all are critical proteins for the proliferation of these viruses, and subsequently maintained in the presence of interleukins 4 and 7 with a novel culture device to expand and sustain the repertoire of CTLs. After an allogeneic hematopoietic stem cell transplant (HSCT), infusion of these CTLs primed towards Adv, CMV and EBV may prevent viral infection by these pathogens.", + "output": "adenovirus/cytomegalovirus/Epstein-Barr virus-specific allogeneic cytotoxic T lymphocytes (Allogeneic Lymphocyte)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol.", + "output": "cis-zeatin anabolism (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Taking a shower.", + "output": "FAC100-Sev: Taking a Shower (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of cellular response to drug.", + "output": "regulation of cellular response to drug (Cell Function)" + }, + { + "input": "Definition: something described as an integer falling within minimum and maximum bounds that specifies how many times the activity occurs. EXAMPLE(S): OTHER NAME(S): NOTE(S): If the frequency is more than once a day, this is still interpreted per time, e.g. BID for 5 days = 10 repeats.", + "output": "Defined Activity Repeat Quantity Range (Repeat Quantity Range)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose.", + "output": "UDP-D-glucose-4,6-hydrolyase activity (Molecular Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+.", + "output": "menthone dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: Pathologic Function described as medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections.", + "output": "Medial degeneration, NOS (Vascular wall degeneration)" + }, + { + "input": "Definition: Antibiotics described as a semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits bacterial septum and cell wall synthesis formation.", + "output": "(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Cephalosporins)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as proteasome subunit alpha type-5 (241 aa, ~26 kDa) is encoded by the human PSMA5 gene. This protein is involved in ATP-dependent protein catabolism.", + "output": "proteasome alpha subunit type 5, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: V [Preparations] described as the hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C76318\" active clinical trials using this agent.", + "output": "Anhydrous, Vardenafil Hydrochloride (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as the directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.", + "output": "Golgi to plasma membrane transport (Cell Function)" + }, + { + "input": "Definition: bradykinin receptor binding described as interacting selectively and non-covalently with a B1 bradykinin receptor.", + "output": "B1 bradykinin receptor binding (Molecular Function)" + }, + { + "input": "Definition: CDISC CDASH Terminology described as a terminology subset of the CDISC Study Data Tabulation Model (SDTM) Frequency codelist created for Clinical Data Acquisition Standards Harmonization (CDASH) Concomitant Medication Dosing Frequency per Interval Terminology.", + "output": "CDASH-CMDOSFRQ (CDISC CDASH Terminology)" + }, + { + "input": "Definition: Intravenous Drip Route of Administration described as a route of administration of a fluid drug form into a vein or veins, over a time duration of equal to or more than 24 hours. Method allows to maintain steady state plasma/serum medication levels, a smaller total daily dose of drug to achieve the same pharmacodynamic endpoint in comparison with intermittent or bolus infusion, and may result in lower toxicity. The method has a positive impact on health-care costs.", + "output": "CIV (Intravenous Drip Route of Administration)" + }, + { + "input": "Definition: Strabismus and other disorders of binocular eye movements described as pathologic process affecting the voluntary or reflex-controlled movements of the eye.", + "output": "disordered eye movements (Cranial nerve diseases)" + }, + { + "input": "Definition: something described as a clinical-stage biotechnology company using gene therapy, cancer immunotherapy, and gene editing to treat and cure genetic diseases and cancer.", + "output": "Bluebird Bio (Company)" + }, + { + "input": "Definition: Transposition of Great Vessels described as an acyanotic congenital cardiovascular abnormality characterized by the transposition of the aorta and the pulmonary artery.", + "output": "L-Transposition of the Great Vessels (Transposition of Great Vessels)" + }, + { + "input": "Definition: Sedatives described as an adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.", + "output": "xylaxine (Adrenergic alpha-2 Receptor Agonists)" + }, + { + "input": "Definition: Plant described as a plant genus of the family FABACEAE that contains LECTINS. Many members have been reclassified into other genera of the FABACEAE family.", + "output": "Dolichos, NOS (Fabaceae)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant neoplasm that affects the bulbomembranous part of the urethra.", + "output": "Bulbomembranous Urethral Malignant Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: something described as human VASH1 wild-type allele is located in the vicinity of 14q24.3 and is approximately 21 kb in length. This allele, which encodes vasohibin-1 protein, plays a role in the regulation of the proliferation and migration of endothelial cells and vascular branch formation.", + "output": "KIAA1036 (Gene or Genome)" + }, + { + "input": "Definition: generation of precursor metabolites and energy described as the light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I.", + "output": "photosynthesis, light reaction (Molecular Function)" + }, + { + "input": "Definition: Chloride Channel Binding described as a process that involves the binding of glycine to a glycine receptor. These interactions are involved in various activities, including synaptic plasticity, learning, memory and inhibition of neurotransmission.", + "output": "Glycine Receptor Binding (Molecular Function)" + }, + { + "input": "Definition: P [Preparations] described as any bacterial organism that can be assigned to the species Providencia rettgeri.", + "output": "Providencia rettgeri (Providencia)" + }, + { + "input": "Definition: Cytoplasmic antibody described as antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.", + "output": "Anti-cardiolipin antibody (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: LABORATORY ABNORMALITIES described as a decreased concentration of free (unbound) carnitine in the blood.", + "output": "Decreased plasma free carnitine (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Intellectual Product described as a question about how often an individual has or had itching.", + "output": "Itching Frequency (Intellectual Product)" + }, + { + "input": "Definition: disease transmission described as the amount time between exposure to an infectious agent and becoming symptomatic.", + "output": "Incubation Period Infectious Disease (Temporal Concept)" + }, + { + "input": "Definition: Chemistry Techniques, Analytical described as a methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for MOLECULARLY IMPRINTED POLYMERS (MIPs) include separations, assays and biosensors, and catalysis.", + "output": "Molecular imprinting (Chemistry, Analytic)" + }, + { + "input": "Definition: Domestic Sheep described as domestic sheep species", + "output": "Ovis aries Linnaeus, 1758 (Domestic mammal)" + }, + { + "input": "Definition: Biliary Tract Infection, CTCAE described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Biliary tract infection (Biliary Tract Infection, CTCAE)" + }, + { + "input": "Definition: MUSCLE SOFT, TISSUE described as a condition in which extra lymph fluid builds up in tissues and causes swelling. It may occur in an arm or leg if lymph vessels are blocked, damaged, or removed by surgery.", + "output": "Lymphatic edema (Pathologic Function)" + }, + { + "input": "Definition: Cancer Vaccines described as a synthetic peptide-based, personalized cancer vaccine consisting of multiple patient-specific tumor peptides, which are immunogenic and unique to the patient's tumor, combined with the immunostimulant polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC), with potential immunomodulating and antineoplastic activities. Upon vaccination with the personalized genomic vaccine 001 (PGV001), the peptides stimulate the host immune system to mount a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. The adjuvant Poly-ICLC is added to boost the immune response to the peptides and together will expand immune cells to target cancer. The adjuvant poly-ICLC is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which may help to boost the immune response against the selected neoantigens.", + "output": "multi-peptide therapeutic vaccine 001 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as low-density lipoprotein receptor (860 aa, ~95 kDa) is encoded by the human LDLR gene. This protein is involved in the endocytosis of cholesterol.", + "output": "LDLCQ2 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Protein Analysis described as the process of determining the sequence of amino acids within a protein molecule.", + "output": "Protein Sequence Determination (Molecular Biology Research Technique)" + }, + { + "input": "Definition: something described as eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis.", + "output": "Regulation of eif-4e and p70s6 Kinase (Regulatory Pathway)" + }, + { + "input": "Definition: something described as a water soluble analogue of the antineoplastic agent brefeldin A (BFA).", + "output": "13-(N,N-Dimethylglycyl)brefeldin A (Pharmacologic Substance)" + }, + { + "input": "Definition: Strongylida described as a superfamily of nematodes of the order STRONGYLIDA. Characteristics include a fluid-filled outer layer of cuticle and a reduced mouth and bursa.", + "output": "Superfamily metastrongyloidea (Strongylida)" + }, + { + "input": "Definition: Invasive Ductal Breast Carcinoma described as an invasive breast carcinoma characterized by the presence of a predominant squamous cell component that is admixed with the ductal carcinomatous component.", + "output": "Ductal Carcinoma of the Breast with Squamous Metaplasia (Neoplastic Process)" + }, + { + "input": "Definition: something described as a non-unique textual identifier specifying the source of the publication identifier.", + "output": "ReferenceToStudyResults.publicationName (Intellectual Product)" + }, + { + "input": "Definition: Finding described as susceptible to unpredicted death of an infant.", + "output": "At risk for sudden infant death syndrome (Finding)" + }, + { + "input": "Definition: Orthoses, Lower Limb, Foot described as foot orthoses designed to support the foot arch by providing some degree of movement control and pressure redistribution. These orthoses typically consist of a semi-rigid prefabricated device that is inserted inside the shoe. The orthoses are made of several layers of different materials (e.g., fabrics, hard plastics) with a shape and size appropriate for the user. Prefabricated foot arch flexible or semi-rigid supports intended for a rigid flatfoot are used for cushioning and pain relief. More rigid orthoses intended for flexible flat foot (i.e., a foot that becomes flat only when standing) and that may be part of a therapy to correct the deformity in children are also available.", + "output": "arch support (Healthcare supplies)" + }, + { + "input": "Definition: Biologically Active Substance described as histone H2B type 2-F (126 aa, ~14 kDa) is encoded by the human H2BC18 gene. This protein plays a role in cellular processes that are modulated by the histone code.", + "output": "H2BC18 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as the various filaments, granules, tubules or other inclusions within mitochondria.", + "output": "Particle, Submitochondrial (Cell Component)" + }, + { + "input": "Definition: something described as an individual component of a clustering. May contain other nodes.", + "output": "Cluster Node (Conceptual Entity)" + }, + { + "input": "Definition: C [Preparations] described as one of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.", + "output": "6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-(((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, (1S,9S)- (Medicinal product categorized by structure)" + }, + { + "input": "Definition: something described as any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.", + "output": "positive regulation of calcium ion import (Cell Function)" + }, + { + "input": "Definition: something described as sodium- and chloride-dependent creatine transporter 1 (635 aa, ~71 kDa) is encoded by the human SLC6A8 gene. This protein plays a role in sodium and chloride ion-dependent transmembrane transport of creatine and phosphocreatine.", + "output": "Creatine Transporter (Biologically Active Substance)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) During the last week, has it been easy or hard for your child to: Walk more than a mile?", + "output": "PODCI1-Walk More Than a Mile (Intellectual Product)" + }, + { + "input": "Definition: formation of extrachromosomal circular DNA described as a telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).", + "output": "telomeric circle formation (Genetic Function)" + }, + { + "input": "Definition: Thymic Carcinoma described as a rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm.", + "output": "Clear Cell Carcinoma of Thymus (Thymic Carcinoma)" + }, + { + "input": "Definition: Fixation of vagina described as vaginopexy according to Williams and Richardson is an abdominal colposuspension by strips from external oblique", + "output": "Harrison-Richardson operation on vagina (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a character or string that represents the full name of the ECG assessment.", + "output": "EGTEST (Intellectual Product)" + }, + { + "input": "Definition: Plant described as a plant genus of the family NYMPHAEACEAE. Members contain sesquiterpene thioalkaloids.", + "output": "Lily, Yellow Pond (Plant)" + }, + { + "input": "Definition: Malignant Leptomeningeal Neoplasm described as a malignant mesenchymal neoplasm arising from the leptomeninges.", + "output": "Leptomeningeal sarcoma (Malignant Leptomeningeal Neoplasm)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (percentage) of the N1 sleep time to total sleep time.", + "output": "N1 Sleep/Total Sleep Time (Laboratory Procedure)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.", + "output": "negative regulation of stress-activated protein kinase signaling pathway (negative regulation of intracellular signal transduction)" + }, + { + "input": "Definition: AVLT-REY Functional Test Question described as auditory Verbal Learning Test - List B, Word 9.", + "output": "AVL0226 (AVLT-REY Functional Test Question)" + }, + { + "input": "Definition: Gene or Genome described as human STAMBP wild-type allele is located in the vicinity of 2p13.1 and is approximately 44 kb in length. This allele, which encodes STAM-binding protein, plays a role in both Myc signaling pathway initiation and cell cycle progression.", + "output": "AMSH (STAMBP gene)" + }, + { + "input": "Definition: Finding described as a wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy.", + "output": "Fold in retina (Retinal defect)" + }, + { + "input": "Definition: Area Under First Moment Curve described as the area under the first moment curve (AUMC) extrapolated to infinity, based on the last predicted concentration divided by the surface area.", + "output": "AUMCIFPS (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child) In the past 7 days, how much of a problem has this been for your child: My child feels tired.", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child - Feel Tired (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)" + }, + { + "input": "Definition: DNA Viruses described as family of archaeal viruses with a single genus: Sulfolobus SNDV-like Viruses.", + "output": "Family Guttaviridae (Virus)" + }, + { + "input": "Definition: something described as jellyfish.", + "output": "Medusa (Homeopathic remedies letter M)" + }, + { + "input": "Definition: Bone structure of upper limb described as one of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist.", + "output": "Ulna (Structure of long bone of upper limb)" + }, + { + "input": "Definition: something described as an insertion of six nucleotides, cytosine-cytosine-cytosine-adenine-cytosine-guanine, between position 2320 and 2321 of the coding sequence of the EGFR gene.", + "output": "NM 005228.4(EGFR):c.2315 2320dupCCCACG (EGFR Exon 20 Insertion Mutation)" + }, + { + "input": "Definition: Pharmacologic Substance described as a cancer vaccine consisting of a recombinant form of human melanoma antigen A3 (MAGE-A3) combined with a proprietary adjuvant with potential immunostimulatory and antineoplastic activities. Upon administration, astuprotimut-R may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the MAGE-A3 antigen, resulting in tumor cell death. MAGE-A3, a tumor-associated antigen (TAA) originally discovered in melanoma cells, is expressed by various tumor types. The proprietary immunostimulating adjuvant in this agent is composed of a specific combination of immunostimulating compounds selected to increase the anti-tumor immune response to MAGE-A3.", + "output": "astuprotimut-R (Cancer Vaccines)" + }, + { + "input": "Definition: something described as a measurement of the circulating endothelial cells in a biological specimen.", + "output": "Circulating Endothelial Cell Count (Laboratory Procedure)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria.", + "output": "bacterial cellulose biosynthesis (Molecular Function)" + }, + { + "input": "Definition: something described as a viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA.", + "output": "double stranded viral RNA replication (Genetic Function)" + }, + { + "input": "Definition: Classification described as a plasma cell myeloma stage defined according to the Revised International Staging System (RISS) criteria.", + "output": "RISS Stage (Disease Stage Qualifier)" + }, + { + "input": "Definition: Cell Function described as the aggregation, arrangement and bonding together of a set of components to form a chloroplast ribulose bisphosphate carboxylase complex.", + "output": "chloroplast ribulose bisphosphate carboxylase complex assembly (Cell Function)" + }, + { + "input": "Definition: Pathologic Processes described as a compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.", + "output": "Epithelioid granuloma (Granuloma)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a human IgG2kappa monoclonal antibody specific for the epidermal growth factor receptor (EGFR). Monoclonal antibody E7.6.3 binds to the EGFR, blocking the binding of epidermal growth factor and transforming growth factor alpha to EGFR-expressing cancer cells and ultimately inhibiting EGFR-dependent cell activation and proliferation.", + "output": "Human IgG2K Monoclonal Antibody (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a character or string used to name or characterize the reference identifier for a returned treatment label.", + "output": "Returned Treatment Label Identifier Reference (Reference ID)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of uterine corpus cancer, following the rules of the TNM AJCC v6 classification system. TNM clinical findings are based on information obtained prior to the first definitive treatment through physical examination, diagnostic imaging, biopsy and laboratory testing.", + "output": "Uterine Corpus Cancer Clinical TNM Finding v6 (Finding)" + }, + { + "input": "Definition: Finding described as a reduced concentration of vitamin K. []", + "output": "Low levels of vitamin K (Abnormality of vitamin K metabolism)" + }, + { + "input": "Definition: Poly C described as interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.", + "output": "polyinosinic-polycytidylic acid (Polynucleotides)" + }, + { + "input": "Definition: Paraclostridium described as a species of gram-positive bacteria in the family Clostridiaceae that ferments both CARBOHYDRATES and AMINO ACIDS.", + "output": "Martellillus bifermentans (Clostridium)" + }, + { + "input": "Definition: something described as a form of lactic acidemia that occurs in relation to stress or infection.", + "output": "Stress/infection-induced lactic acidosis (Acidosis, Lactic)" + }, + { + "input": "Definition: ACC-AHA Measure described as the sequelae of treatment given for Kawasaki disease.", + "output": "Intervention for Kawasaki Disease, Sequelae (ACC-AHA Measure)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Throwing things at friends or family members.", + "output": "TSCYC - Throwing Things at Friends/Family (Intellectual Product)" + }, + { + "input": "Definition: Geographic Area described as an independent state, an archipelago in the western Persian Gulf, northwest of Qatar. It comprises low-lying islands of Bahrain (the largest), Muharraq, Sitra, and several islets. It has extensive oil fields. The name comes from the Arabic al-bahrayn, \"the two seas\", with reference to its lying in the middle of a bay with its \"two seas\" east and west of it.", + "output": "BAHRAIN (Middle East)" + }, + { + "input": "Definition: LABORATORY ABNORMALITIES described as an abnormal increased concentration of parathyroid hormone.", + "output": "Elevated circulating parathyroid hormone level (Abnormal calcium-phosphate regulating hormone level)" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs that make tumor cells more sensitive to radiation therapy.", + "output": "Radiation-Sensitizing Agents (Therapeutic Uses)" + }, + { + "input": "Definition: Study Activity described as a candidate's agreement to carry out investigations or trials that are not required by any legal provision.", + "output": "postmarketing commitment (Study Activity)" + }, + { + "input": "Definition: Generalized glycogen storage disease of infants described as glycogen storage disease due to acid maltase deficiency, late onset (AMDL), a form of Glycogen storage disease due to acid maltase deficiency (AMD), a degenerative metabolic myopathy particularly affecting respiratory and skeletal muscles, is characterized by an accumulation of glycogen in lysosomes.", + "output": "Lysosomal alpha-1,4-glucosidase deficiency - adult onset (Generalized glycogen storage disease of infants)" + }, + { + "input": "Definition: cell cycle process described as the alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.", + "output": "metaphase plate congression (cell cycle process)" + }, + { + "input": "Definition: Genetic Function described as any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid.", + "output": "nucleoid DNA packaging (Genetic Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.", + "output": "Tetramethylazoformamide (Azo Compounds)" + }, + { + "input": "Definition: Abnormal epiphysis morphology of the phalanges of the hand described as bracket epiphysis refers to an abnormality in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.", + "output": "Bracket shaped end part of finger bones (Bracket epiphyses)" + }, + { + "input": "Definition: Penile Infection, CTCAE described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Penile Infection, CTCAE (Finding)" + }, + { + "input": "Definition: Dispensers, Medication described as a liquid medication dispenser is a device intended for medical purposes that is used to issue a measured amount of liquid medication.", + "output": "Liquid Dispensers, Medication (Medical Device)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure.", + "output": "anterior midgut development (Organ or Tissue Function)" + }, + { + "input": "Definition: Multiple malformation syndrome due to environmental agent described as a teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems.", + "output": "Foetal alcohol syndrome (Congenital malformation syndromes due to known exogenous causes, not elsewhere classified)" + }, + { + "input": "Definition: something described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 3, Word 13.", + "output": "ADNI AVLT - List A Recall 3 Word 13 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as north Star Ambulatory Assessment - Can you walk from A to B (state to and where from) for me.", + "output": "NSAA - Walk (NSAA Clinical Classification Question)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as process in which a patient is induced into a trance-like state in order to relieve anxiety during a dental procedure.", + "output": "Dental Hypnoses (Hypnosis, Anesthetic)" + }, + { + "input": "Definition: Congenital malformation of uterus and cervix described as a uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn.", + "output": "Uterus unicornis (Congenital Abnormality)" + }, + { + "input": "Definition: Organ or Tissue Function described as the hemodynamic and electrophysiological action of the RIGHT ATRIUM.", + "output": "Functions, Right Atrial (Organ or Tissue Function)" + }, + { + "input": "Definition: cell migration involved in gastrulation described as the directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.", + "output": "dorsal convergence (Cell Function)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of interleukin 2 receptor present in a sample.", + "output": "Interleukin 2 Receptor Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.", + "output": "DNA Molecular Biology (Biochemistry)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated from peripheral blood leukocytes pulsed with mRNA encoding for a fusion protein comprised of the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused with the lysosome-associated membrane protein (pp65-LAMP) and radiolabeled with the isotope indium In 111, with potential ability to track DC migration upon single-photon emission computed tomography (SPECT)/ computed tomography (CT). Upon intradermal injection of the indium In 111-autologous CMV pp65-LAMP mRNA loaded DCs into the groin area, the DCs migrate in vivo to the inguinal lymph nodes. Upon SPECT/CT imaging, DC in vivo migration to the lymph nodes can be assessed.", + "output": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells (Radioimmunoconjugates)" + }, + { + "input": "Definition: Influenza A virus subtype H9 described as a subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 9 and neuraminidase 2. The H9N2 subtype usually infects domestic birds (POULTRY) but there have been some human infections reported.", + "output": "Viruses, H9N2 (Influenza A virus subtype N2)" + }, + { + "input": "Definition: Sequence Analysis, DNA described as a procedure that can determine the DNA sequence for nearly the entire genome of an individual.", + "output": "Sequencing, Complete Genome (Sequence Analysis, DNA)" + }, + { + "input": "Definition: Balance exerciser described as balance exercisers designed to improve the user's ability to maintain proper posture when walking or running by partially suspending the user. These exercisers usually consist of a suspension system; patient handrails that support the user in standing positions; walking slings for partially lifting and supporting the user, which are suspended by the hanger overhead; and attached locking casters that can be used to move the device from one place to another. These exercisers are battery-powered, although the weights to be offloaded may be manually adjusted; they are capable of lifting patients from wheelchairs and may also be used with a treadmill to allow users to exercise. Patient lifting balance exercisers are used in physical therapy and rehabilitation to improve balance, coordination; muscle strength, and muacle tone in the lower limbs.", + "output": "Exercisers, Balance, Patient Lifting (Balance exerciser)" + }, + { + "input": "Definition: Congenital Abnormality described as absence of a region of the retina, retinal pigment epithelium, and choroid.", + "output": "Choroidoretinal coloboma (Congenital Abnormality)" + }, + { + "input": "Definition: cellular diagnosis, thymoma and thymic carcinoma described as an epithelial neoplasm arising from the thymus. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It includes thymoma type B1 which is a thymoma of low grade malignant potential, thymoma type B2 which is a thymoma of moderate malignancy, and thymoma type B3 which is also known as well differentiated thymic carcinoma.", + "output": "type B thymoma (Neoplastic Process)" + }, + { + "input": "Definition: response to organic cyclic compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus.", + "output": "response to polycyclic arene (drug response)" + }, + { + "input": "Definition: Quantitative Concept described as predicted accumulation ratio for area under the curve (AUC) calculated using the Lambda z estimated from single dose data.", + "output": "Accumulation Index using Lambda z (Area Under Curve)" + }, + { + "input": "Definition: Lymphadenopathy described as enlargement of the cervical lymph nodes usually due to infections or involvement by malignant neoplasms.", + "output": "CERVICAL LYMPH NODE ENLARGEMENT (Disease or Syndrome)" + }, + { + "input": "Definition: Functional Concept described as a description of the functional change at the level of the intended target of the pharmacologic intervention.", + "output": "Planned Pharm Target Mode of Action (Mode of Action)" + }, + { + "input": "Definition: something described as a census division of the United States consisting of Alaska, California, Hawaii, Oregon, and Washington.", + "output": "Census Division 9 (Geographic Area)" + }, + { + "input": "Definition: Surgical Drapes, Operating Table described as operating table surgical drapes intended for multiple uses that provide a barrier between the unsterile surface of the operating table they cover and the sterile surgical field. These operating table surgical drapes consist of a broad rectangular piece of fabric. They are made of woven materials that also provide liquid-proof protection. Reusable operating table surgical drapes are used in the operating room for one procedure and can then be disinfected and used again. They are available in many different materials such as cotton, polyester, or a blend of both.", + "output": "Surgical Drapes, Operating Table, Reusable (Medical Device)" + }, + { + "input": "Definition: Neoplastic Process described as advanced hepatocellular carcinoma. Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)", + "output": "Barcelona Clinic Liver Cancer Stage C Hepatocellular Carcinoma (Hepatocellular Carcinoma by BCLC Stage)" + }, + { + "input": "Definition: Web Site described as a Web-based resource that provides patients, their family members, health care professionals, researchers, and the public with access to information on publicly and privately supported clinical studies. A service of the National Institutes of Health (NIH), ClinicalTrials.gov is both a registry and a results database.", + "output": "ClinicalTrials.gov (Web Site)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.", + "output": "down regulation of DNA endoreduplication (negative regulation of DNA-dependent DNA replication)" + }, + { + "input": "Definition: Antibiotics described as a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms.", + "output": "7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid (Organic Chemical)" + }, + { + "input": "Definition: Disease or Syndrome described as diseases caused by DNA VIRUSES.", + "output": "DNA Virus Infections (Virus Diseases)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "output": "embryonic heart tube morphogenesis (epithelial tube morphogenesis)" + }, + { + "input": "Definition: CPTAC Responses described as a response that tumor progression was present after initial treatment.", + "output": "Tumor Progression Present After Initial Treatment (Finding)" + }, + { + "input": "Definition: Ascending aorta structure described as any one of the naturally occurring sinuses of the aortic root distal to the semilunar valve.", + "output": "sinus of valsalva (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Image-Guided Therapy described as a procedure that uses radioactive substances to locate tumors so that they can be removed by surgery.", + "output": "Radioguided Surgery (Surgical Procedure by Method)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of seed maturation.", + "output": "positive regulation of seed maturation (positive regulation of post-embryonic development)" + }, + { + "input": "Definition: something described as autonomic status epilepticus is a type of non-convulsive status epilepticus without coma with prominent autonomic features regardless of whether it is electrographically generalized or focal.", + "output": "Autonomic status epilepticus (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a phyllodes tumor of the breast characterized by the presence of intermediate features and a stroma which usually resembles low grade fibrosarcoma.", + "output": "Borderline Breast Phyllodes Tumor (Borderline phyllodes tumor)" + }, + { + "input": "Definition: Salmonella paratyphi described as a serotype of SALMONELLA ENTERICA which is an agent of PARATYPHOID FEVER in Asia, Africa, and southern Europe.", + "output": "Salmonella hirschfeldii (Enterobacteriaceae)" + }, + { + "input": "Definition: something described as the statistical manipulation of hierarchically and non-hierarchically nested data. It includes clustered data, such as a sample of subjects within a group of schools. Prevalent in the social, behavioral sciences, and biomedical sciences, both linear and nonlinear regression models are applied.", + "output": "Multilevel Analyses (Multivariate Analysis)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoma that arises from the lip and has metastasized to another anatomic site.", + "output": "Metastatic Lip Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose.", + "output": "trihexosylceramide alpha-galactosidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as animal disease whose pathologic mechanisms are sufficiently similar to those of a human disease for the animal disease to serve as a model.", + "output": "Animal Disease Model (Animal Model)" + }, + { + "input": "Definition: Pharmacologic Substance described as an ointment that can potentially be used to treat vascular endothelial growth factor receptor (VEGFR) inhibitor (VEGFRi)-associated hand-foot skin reaction (HFSR).", + "output": "OQL011 (Topical Preparation)" + }, + { + "input": "Definition: Anesthesia procedures described as state characterized by loss of feeling or sensation caused by anesthetics; depression of nerve function is induced to decrease pain during labor and childbirth.", + "output": "anesthesia obstetric (Anesthesia procedures)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder caused by the presence of an extra chromosome 21 and characterized by mental retardation and distinguishing physical features.", + "output": "Syndrome, Down's (Down Syndrome)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as infusing a substance into a client/patient through a peripheral vein for therapeutic effect(s). For each additional substance, use DDBDM. Service is billed per infusion.", + "output": "IV THERAP.inf nshl inf (Injection procedure)" + }, + { + "input": "Definition: Immunology described as a clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.", + "output": "Chronic mucocutan candidiasis (Candidiasis)" + }, + { + "input": "Definition: SIQ Questionnaire Question described as suicidal Ideation Questionnaire (SIQ) I thought about how I would kill myself.", + "output": "SIQ0103 (SIQ Questionnaire Question)" + }, + { + "input": "Definition: Coal described as a high-grade metamorphic coal having a semimetallic luster, high content of fixed carbon, and high density, and burning with a short blue flame and little smoke or odor.", + "output": "Anthracite (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in ATP-dependent chromatin remodeling.", + "output": "INO80D (Genes, Regulator)" + }, + { + "input": "Definition: something described as a non-taxonomic grouping of bacterial species that are phenotypically or genetically similar to the Citrobacter freundii species.", + "output": "CITROBACTER FREUNDII COMPLEX (Bacterium)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine cortisol metabolites, including 17-hydroxycorticosteroids (17-OHCS) and 17-ketosteroid glucoronides (17-KS-G). Other cortisol metabolites include tetrahydro metabolites (e.g. tetrahydrocortisone), hexahydro metabolites (e.g., alpha and beta cortols, cortolones), and 11-oxygenated ketosteroids (e.g., 11-ketoandrosterone). Determination of cortisol metabolites in urine are used in tests of adrenal diseases such as nodular adrenocortical diseases and secondary adrenal insufficiency. The assays for determination of cortisol, both in urine and blood, have decreased the use of tests for cortisol metabolites in urine.", + "output": "IVD Test Reagent/Kits, Immunoassay, Neuroendocrine, Cortisol Metabolite (Medical Device)" + }, + { + "input": "Definition: something described as applying an electrical current to acupuncture needles in situ on a client's body part, region or full body to facilitate a transdermal current between two or more acupoints. Service is billed in 15-minute increments.", + "output": "Electrical acupuncture each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as abnormal Involuntary Movement Scale - Facial and Oral Movements, Lips and perioral area, e.g., puckering, pouting, smacking.", + "output": "AIMS - Lips and Perioral Area (Intellectual Product)" + }, + { + "input": "Definition: something described as a population of cytotoxic T-lymphocytes (CTLs) that are therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species.", + "output": "therapeutic allogeneic cytotoxic T lymphocytes (Allogeneic Lymphocyte)" + }, + { + "input": "Definition: Programming Languages described as a specification of the W3C that provides markup of documents for display in a web browser. [HL7] Contrast to XML.", + "output": "HTML (Programming Languages)" + }, + { + "input": "Definition: something described as the Overactive Bladder Questionnaire (OAB-q) Waking up at night because you had to urinate?", + "output": "OABQ0106 (OAB-q Questionnaire Question)" + }, + { + "input": "Definition: Finding described as a bending or abnormal curvature of the tibia.", + "output": "Bowed shinbone (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the banded granulocytes to total cells in a biological specimen.", + "output": "GRANBCE (Laboratory Procedure)" + }, + { + "input": "Definition: Drug Administration Routes described as a route that begins within the interstices of a tissue.", + "output": "Interstitial route (RouteBySite)" + }, + { + "input": "Definition: proteolysis associated with antigen processing and presentation described as the hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.", + "output": "endosomal proteolysis associated with antigen processing and presentation (proteolysis associated with antigen processing and presentation)" + }, + { + "input": "Definition: Cell described as a population of T cells that have been sensitized to vaccine tumor antigen(s) in vivo; collected from the patient; co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo; and then infused into the same patient. CD3, part of the T cell receptor complex, and CD28, a T-cell surface-associated co-stimulatory molecule, are both required for full T-cell activation. Adoptive transfer of CD3/CD28 costimulated vaccine-primed autologous T-cells may induce the production of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and associated antitumor effects and a graft-versus-tumor (GVT) response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74017\" active clinical trials using this agent.", + "output": "CD3/CD28 costimulated vaccine-primed autologous T-cells (Cell)" + }, + { + "input": "Definition: something described as mapping the practitioner type or specialty to a radiosurgery code. Use associated HCPCS II codes to bill for radiosurgery service(s). This code is used for scope-of-practice mapping, not for billing.", + "output": "Nnspcfd HCPCS radiosurgery (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: Uterine Non-Neoplastic Disorder described as a non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.", + "output": "Cervical Non-Neoplastic Disorder (Uterine Non-Neoplastic Disorder)" + }, + { + "input": "Definition: ESS Questionnaire Question described as epworth Sleepiness Scale - As a passenger in a car for an hour without a break.", + "output": "ESS01-Passenger for Hour Without Break (ESS Questionnaire Question)" + }, + { + "input": "Definition: Embryonic Structures described as early stage in the development of a plant or an animal. In vertebrate animals (have a backbone or spinal column), this stage lasts from shortly after fertilization until all major body parts appear. In particular, in humans, this stage lasts from about 2 weeks after fertilization until the end of the seventh or eighth week of pregnancy.", + "output": "Embryo (Embryonic Structures)" + }, + { + "input": "Definition: something described as a question about whether an individual walked leisurely for exercise or pleasure.", + "output": "Did you walk leisurely for exercise or pleasure (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Exhaustion described as a condition in which a person is so tired or weak that he or she is unable to do anything.", + "output": "PROSTRATION (Sign or Symptom)" + }, + { + "input": "Definition: Solid Dose Form described as a small circular object with a vacant circular center that is usually intended to be placed in the body by special inserters, where the medication is released, generally for localized effects.", + "output": "RING (Biomedical or Dental Material)" + }, + { + "input": "Definition: Myeloid Leukemia in Remission described as chronic myeloid leukemia not growing; responding to treatment.", + "output": "CML (chronic myelogenous leukemia) in remission (Myeloid Leukemia, Chronic)" + }, + { + "input": "Definition: Nutritional Study described as epidemiology studies looking at the role of dietary patterns, foods, and nutrients or other dietary components in cancer incidence and prevention.", + "output": "Diet and nutrition (Nutritional Study)" + }, + { + "input": "Definition: Protein Tyrosine Kinase described as megakaryocyte-associated tyrosine-protein kinase (507 aa, ~56 kDa) is encoded by the human MATK gene. This protein is involved in cell proliferation and tyrosine phosphorylation.", + "output": "megakaryocyte-associated tyrosine kinase, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: regulation of heat generation described as any process that modulates the rate or extent of fever generation.", + "output": "regulation of pyrexia (regulation of heat generation)" + }, + { + "input": "Definition: Neoplastic Process described as metastatic gestational trophoblastic tumor in which risk factors are absent.", + "output": "trophoblastic tumor, metastatic, good prognosis (stage, gestational trophoblastic tumor)" + }, + { + "input": "Definition: Finding described as an adverse event in a newborn characterized by a single, self-limited electroencephalogram (EEG)-proven seizure requiring no treatment.", + "output": "Grade 1 Neonatal Epileptic Seizure, AE (Neonatal Epileptic Seizure, Adverse Event)" + }, + { + "input": "Definition: Ataxia, Spinocerebellar described as a group of dominantly inherited, predominatly late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)", + "output": "OPCA with Retinal Degeneration (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: something described as neuropsychiatric Inventory (NPI) Is the patient cranky and irritable?", + "output": "NPI - Cranky and Irritable (Intellectual Product)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as the response of the central nervous system to treatment", + "output": "CNS Response (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as rapidly developing osteoporosis characterised primarily by bone marrow oedema of a self-limiting nature.", + "output": "osteoporosis transient (Acute disease of bone)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin.", + "output": "p-hydroxyphenyl lignin degradation (p-hydroxyphenyl lignin metabolic process)" + }, + { + "input": "Definition: Cardiovascular Diseases described as presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.", + "output": "NEAR SYNCOPE (Abnormal cardiovascular system physiology)" + }, + { + "input": "Definition: something described as a composite substructure of the cerebellar cortex based on an alternate mode of grouping the lobes and lobules thereof ( Crosby-1962 ).", + "output": "middle lobe of Elliot Smith (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Tic disorder described as a neurological disorder presenting in childhood that is characterized by motor and/or phonic tics that occur daily or nearly daily for one to twelve months and are not attributed to an identifiable cause.", + "output": "Benign Tic Disorder of Childhood (other psychiatric disorders)" + }, + { + "input": "Definition: Intellectual Product described as brief Pain Inventory - I take my pain medicine (in a 24 hour period).", + "output": "BPI1-Take my Pain Medicine (BPI Questionnaire Question)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.", + "output": "positive regulation of skeletal muscle hypertrophy (positive regulation of muscle adaptation)" + }, + { + "input": "Definition: Pharmacologic Substance described as an electrolyte-free emulsion for infusion consisting of a three chamber bag system containing glucose, amino acids and lipids that can be used to provide parenteral nutritional supplementation. The lipid emulsion portion contains soybean oil, medium-chain triglycerides, olive oil and fish oil; the amino acid solution contains alanine, arginine, glycine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, and valine. The electrolyte-free parenteral nutrition emulsion contains no electrolytes, trace elements and vitamins. The three separate bags containing glucose, amino acids and lipids are mixed together before infusion. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97255\" active clinical trials using this agent.", + "output": "electrolyte-free parenteral nutrition emulsion (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as a disorder characterized by blockage of the urostomy.", + "output": "Urostomy obstruction (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: something described as a powder intended for injection following reconstitution to form a suspension that is designed to release active and/or inert ingredient(s) at a controlled, prolonged rate so as to reduce dosing frequency.", + "output": "Powder for Prolonged-release Suspension for Injection Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Tobacco abuse prevention described as instruction or training that encourages behaviors most likely to optimize health potentials through information about tobacco abuse; facilitates the prevention of tobacco abuse, frequently for those who are at risk; also includes instruction or training that increases the awareness and favorably influences the attitudes and knowledge about tobacco abuse on a personal or community basis; it also includes the training of medical personnel about tobacco abuse for prevention or treatment programs, for this type of tobacco abuse education postcoordinate with the appropriate health professional education term; this concept may overlap with TOBACCO ABUSE PREVENTION.", + "output": "tobacco abuse education (Educational Activity)" + }, + { + "input": "Definition: Severities described as a prominent or noticeable characteristic.", + "output": "Marked (General Qualifier)" + }, + { + "input": "Definition: something described as a yolk sac tumor that arises from the testis and is characterized by the presence of myxomatous tissue that contains collections of malignant cells with prominent nucleoli.", + "output": "Testicular Yolk Sac Tumor, Myxomatous Pattern (Neoplastic Process)" + }, + { + "input": "Definition: something described as aligning caretaking practices with the preterm infant's individual developmental and physiological needs to support growth and development", + "output": "care infant preterm (nursing care of newborn)" + }, + { + "input": "Definition: Cancer Vaccines described as autologous tumor cells transfected with a plasmid expressing recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) and bifunctional short hairpin RNA (bi-shRNA) against furin, with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination of bi-shRNA-furin/GM-CSF-expressing autologous tumor cell vaccine, expressed GM-CSF protein, a potent stimulator of the immune system, recruits immune effectors to the site of injection and promotes antigen presentation. The furin bifunctional shRNA blocks furin protein production. Decreased levels of furin lead to a reduction in the conversion of transforming growth factor (TGF) beta into TGF beta1 and beta2 protein isoforms. In turn, as part of the negative feedback mechanism, reduced furin protein levels inhibit TGFbeta1 and TGFbeta2 gene expression, thereby further decreasing TGF levels. As TGFs are potent immunosuppressive cytokines, reducing their levels may activate the immune system locally and this may eventually cause a cytotoxic T-lymphocyte (CTL) response against the tumor cells.", + "output": "bi-shRNA-Furin and Granulocyte Macrophage Colony Stimulating Factor Augmented Autologous Tumor Cell Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: Aspirator described as aspirators designed to provide suction for evacuation of gas, body fluids, or foreign materials that may accumulate between the lung and chest wall (i.e., pleural space). These aspirators typically consist of a powered low-vacuum (> 50 mm Hg) and high-volume (> 20 liter/min) pump; collection canisters; plastic tubes connecting the components each other; an overflow protection and/or bacteria filter; and suction tubing (e.g., tubes, catheters, cannulae). The devices can be line-or battery-powered, mobile or portable. Thoracic aspirators are intended to evacuate gas and body fluids after thoracic surgery, trauma in the chest, or after cardiac bypass surgery. They are used mainly when suction from a central vacuum system is not available or appropriate.", + "output": "Thoracic Aspirators (Medical Device)" + }, + { + "input": "Definition: Laboratory Procedure described as a modification of the standard polymerase chain reaction that increases the ability to preferentially amplify mutant alleles in the presence of an excess of wild-type molecules. Wild-type molecules are rendered inactive for amplification by binding of a peptide nucleic acid (PNA) probe that hybridizes to wild-type sequence with greater affinity and under less stringent conditions.", + "output": "PCR Clamp (Laboratory Procedure)" + }, + { + "input": "Definition: something described as >5.0 x ULN and with signs or symptoms", + "output": "Grade 4 Lipase Increased, CTCAE (Finding)" + }, + { + "input": "Definition: something described as ambulatory and capable of all self-care but unable to carry out any work activities. Up and about more than 50% of waking hours", + "output": "PS2 (Quantitative Concept)" + }, + { + "input": "Definition: Gonadal neoplasm described as tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.", + "output": "Tumor of ovary (Mass of ovary)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as couinaud segment III, corresponding to the lateral segment of the left lobe of the liver, located to the left of the inferior portion of the falciform ligament, anteriorly overlapping the stomach.", + "output": "Couinaud Segment III (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: ESR2 Status described as an indication that expression of ESR2 has been detected in a sample.", + "output": "ESR2 Positive (Positive Laboratory Test Result)" + }, + { + "input": "Definition: non-person living subject described as a non-human living organism that has membranous cell walls, requires oxygen and organic foods, and is capable of voluntary movement, as distinguished from a plant or mineral. EXAMPLE(S): dog, cat, mouse, microorganism OTHER NAME(S): NOTE(S):", + "output": "Kingdom Animalia (Chordata)" + }, + { + "input": "Definition: Intercalated Duct described as the tiny tubules with a very thin epithelial layer in the salivary glands running from the salivary acini into the striated duct.", + "output": "Intercalated Duct of the Salivary Gland System (Anatomical Structure)" + }, + { + "input": "Definition: Physical Phenomenon or Property described as union of opposing surfaces.", + "output": "Process of adhesion (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Body Space or Junction described as a region of cell-cell contact between adjacent cells in an epithelial layer.", + "output": "Epithelial Cell Junction (Intercellular Junctions)" + }, + { + "input": "Definition: something described as ultrasonic scanning software designed to operate intracardiac scanning systems and control/monitor a limited number of their functions. This software is intended to work only with one or a few models of ultrasonic scanning systems, usually supplied by the same manufacturer. The software performs a variety of algorithms to facilitate the analysis of measurements performed during the scanning procedure and the sending/receiving of patient data from and to information systems. Intracardiac ultrasonic scanning system software is usually not available separate from the ultrasonic system but may be updated (i.e., through the release of modified versions) during the life of the system.", + "output": "Intracardiac Ultrasonic Scanning Software (Software, Ultrasonic Scanning)" + }, + { + "input": "Definition: Autonomic plexus described as autonomic plexus that runs through the capsule of the prostate and is derived from the inferior hypogastric plexus, and supplies the cavernous nerves of the erectile tissue of penis", + "output": "Prostatic sympathetic plexus (Autonomic plexus)" + }, + { + "input": "Definition: response to organic cyclic compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus.", + "output": "response to cobalamin (drug response)" + }, + { + "input": "Definition: something described as a species of non-enveloped and spherical viruses with a capsid with T=3 icosahedral symmetry in the Caliciviridae family and Norovirus genus. The genome is composed of single-stranded, positive-sense RNA. Norwalk viruses are found in humans and causes acute viral gastroenteritis. Norwalk viruses are transmitted via oral ingestion or fecal-oral contamination.", + "output": "Norwalk agent (Virus)" + }, + { + "input": "Definition: White blood cell count laboratory result described as a measurement of the myelocytes in a biological specimen.", + "output": "Myelocytes (Laboratory Procedure)" + }, + { + "input": "Definition: Pharmacologic Substance described as phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.", + "output": "Calixarenes (Pharmacologic Substance)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Pregnancy Hormone, Estriol described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine the steroid hormone estriol (E3), produced mostly by the placenta in pregnant women, before it is metabolized (i.e., conjugated) by the liver as glucoronides and sulfates. Maternal serum concentrations of unconjugated estriol are probably a better indicator of fetoplacental function than total estriol.", + "output": "IVD Test Reagent/Kits, Immunoassay, Pregnancy Hormone, Estriol, Unconjugated (Medical Device)" + }, + { + "input": "Definition: Obstetric Delivery described as death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.", + "output": "FETAL DEATH (Other complications of birth; puerperium affecting management of mother)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5, Standard Version - Exposure to toxic substance (for example, dangerous chemicals, radiation): Happened to me.", + "output": "LEC0105A (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Protein-Serine-Threonine Kinases described as serine/threonine-protein kinase mTOR (2549 aa, ~289 kDa) is encoded by the human MTOR gene. This protein is involved in protein phosphorylation, signaling and cell growth.", + "output": "mTOR (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Disease or Syndrome described as antley-Bixler Syndrome phenotype with normal genitalia and normal steroidogenesis, and associated with autosomal dominant mutations in FGFR2, the gene for FIBROBLAST GROWTH FACTOR RECEPTOR 2.", + "output": "Osteodysgenesis, Multisynostotic, With Fractures (Disease or Syndrome)" + }, + { + "input": "Definition: Genetic Function described as any gene mutation that occurs in the sequences upstream from a coding region of interest.", + "output": "5' Flank Mutation (Gene Mutation)" + }, + { + "input": "Definition: Work described as labor support for research. EXAMPLE(S): protocol management, registration management, data management, and statistical management.", + "output": "services (Work)" + }, + { + "input": "Definition: Follicular thyroid carcinoma described as a term that refers to the staging of follicular thyroid gland carcinoma, following the rules of the TNM AJCC v8 classification system.", + "output": "Thyroid Gland Follicular Carcinoma by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Cell Component described as a protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.", + "output": "alphaPDGFR-SHP-2 complex location (plasma membrane protein complex)" + }, + { + "input": "Definition: Molecular Function described as enables the directed movement of oxygen into, out of or within a cell, or between cells.", + "output": "globin (Molecular Function)" + }, + { + "input": "Definition: Organic Chemical described as a parenteral antibiotic preparation containing imipenem and cilastatin sodium with bactericidal activity. Imipenem, a broad spectrum beta-lactam antibiotic, binds to penicillin-binding proteins (PBP) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium is added to reduce breakdown of imipenem by kidney dehydropeptidase. This agent is effective against both gram positive and negative bacteria and is often used in treating severe infections caused by multiresistant organisms.", + "output": "Imipenem/ Cilastatin Sodium (Monobactams)" + }, + { + "input": "Definition: Health behavior described as adherence by a patient or client to professional advice or a systematic plan of treatment.", + "output": "Client Adherence (Individual Behavior)" + }, + { + "input": "Definition: Intellectual Product described as systems designed for communication between staff members or staff and patients, as well as for the general public, in a healthcare facility. These systems consist of a central communication station with a power supply and switching capabilities and means to interconnect individual devices (e.g., telephones, pagers, loudspeakers) for transmission and/or reception of voice, messages, and/or pictures. Hospital communication systems may transmit signals using wires or may transmit signals using electromagnetism (e.g., radiofrequency, microwaves) through the air (i.e., wireless). Dedicated systems used for patient/staff communication (e.g., nurse call systems, pagers), interstaff communication (e.g., telephonic, message, paging), and/or general public announcements (e.g., loudspeaker systems) are available.", + "output": "System, Hospital Communication (Diagnostic, Therapeutic, and Research Equipment)" + }, + { + "input": "Definition: something described as a profound hemodynamic and metabolic disturbance characterized by the failure of the circulatory system to maintain adequate perfusion of vital organs; causes inadequate delivery of nutrients and insufficient removal of cellular waste products to and from the tissues.", + "output": "shock syndrome (Cardiovascular System Disorders, General and NEC)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a splicing isoform of CD45 antigen that includes exon B.", + "output": "Cluster of differentiation antigen 45 RB (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: physical trauma type described as dislocation of a given joint repeated times. []", + "output": "Recurr.joint disloc.-site unsp (physical trauma type)" + }, + { + "input": "Definition: intrinsic component of presynaptic endosome membrane described as the component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.", + "output": "integral component of presynaptic endosome membrane (Cell Component)" + }, + { + "input": "Definition: Ophthalmological equipment described as ophthalmic diagnostic instruments designed for examining the eye (mostly the back of the eye, the fundus) The instruments usually consist of a light source incorporated into a wheel of lenses of varying strength (direct ophthalmoscopes) or a light source attached to a headband and a converging lens put in front of the eye of the patient (indirect ophthalmoscopes). They provide a magnified image of the eye, especially the fundus. Ophthalmoscopes are used mainly to detect eye conditions or eye diseases.", + "output": "Funduscope (Clinical diagnostic instrument)" + }, + { + "input": "Definition: MSQOL-54 Questionnaire Question described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Did you feel rested on waking in the morning?", + "output": "MSQOL-54 - Feel Rested Waking in the Morning (MSQOL-54 Questionnaire Question)" + }, + { + "input": "Definition: something described as upper limb prostheses designed for partial functional (e.g., rotation, flexion) and/or cosmetic replacement of the distal portion of a limb at the wrist articulation, in which the radial component of the articulation is preserved. These prostheses are typically external or partially implantable devices that include a mechanism to provide rotational and flexion movements and locking positions at the distal end to the terminal device; they are usually attached at the proximal end with a socket that preserves pronation and supination. The prosthesis includes a terminal device (e.g., hand, hook) at the distal end; the use of a \"screwdriver\" type socket provides stability at the distal portion and transmits rotation. The prostheses may be mechanically operated (e.g., using cables and springs), electrically powered (e.g., using external motors and switches), or triggered by electrical signals produced by normal muscle contractions (i.e., myoelectric). Disarticulation wrist prostheses are available in a great variety of configurations and sizes; they are used mainly in patients who have congenital abnormalities or who suffered amputations due to illness (e.g., diabetes) or traumatic accidents.", + "output": "Wrist Disarticulation Prostheses (Upper Limb Prostheses)" + }, + { + "input": "Definition: Narcotic Antagonists described as a prolonged-release tablet formulation composed of the hydrochloride salt form of the opioid receptor agonist oxycodone and the hydrochloride salt form of the opioid receptor antagonist naloxone which may produce analgesia while relieving opioid-mediated gastrointestinal (GI) side effects. Upon oral administration, oxycodone binds to opioid receptors, thereby mimicking the effects of endogenous opiates to provide analgesia. As naloxone is very poorly absorbed, this agent binds locally to opiate receptors in the GI tract, thereby preventing oxycodone from binding to these receptors. This relieves the opioid-related side effects on the GI tract, including opioid-induced constipation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C103824\" active clinical trials using this agent.", + "output": "oxycodone hydrochloride/naloxone hydrochloride prolonged-release tablet (Opioid Receptor Agonist)" + }, + { + "input": "Definition: Finding described as an indication that a subject is still undergoing therapy to prevent, mitigate or cure a disease.", + "output": "Ongoing Treatment (Event Occurrence Indicator)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as immersing a client's body part or region in alternating extremes of hot and cold water to create a vascular reaction. Service is billed per bath.", + "output": "bathing contrast (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Medical Device described as containers that are typically round or kidney shaped, concave, and wider than they are deep. These containers are used for holding, mixing, and/or storing foods, liquids, bodily fluids, and/or devices/supplies. These containers may be reusable (e.g., made of metal or ceramics that can be cleaned/autoclaved) or disposable (e.g., made of plastic or cardboard).", + "output": "Bowls (Device associated with bowls)" + }, + { + "input": "Definition: Finding described as a response indicating that an individual feels or felt quite a bit of urinary frequency or urgency, making it necessary to be near a bathroom most of the time.", + "output": "Quite a Bit of Urinary Frequency or Urgency; Need to be Near Bathroom Most of the Time (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk & Resilience Inventory-2 - During childhood: I got along well with my family members.", + "output": "DRRI1B01 (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: RNA 2'-O-methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.", + "output": "rRNA (guanosine-2'-O-)-methyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Perinatal cardiovascular disorders described as a syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).", + "output": "Persistent Fetal Circulation (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: regulation of programmed cell death described as any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "modulation of host PCD (Organism Function)" + }, + { + "input": "Definition: something described as stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1). T4a: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T4b: Very advanced local disease. Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension. M0: No distant metastasis. M1: Distant metastasis.", + "output": "Stage IV Nasal Cavity Cancer (Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v7)" + }, + { + "input": "Definition: Neurobehavioral Manifestations described as a state of elevated excitement with over-activity sometimes accompanied with psychotic symptoms (e.g., PSYCHOMOTOR AGITATION, inflated SELF ESTEEM and flight of ideas). It is often associated with mental disorders (e.g., CYCLOTHYMIC DISORDER; and BIPOLAR DISEASES).", + "output": "Manic states (Mood alterations with manic symptoms)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had joint pain or muscle cramps.", + "output": "Have Joint Pain or Muscle Cramps (Intellectual Product)" + }, + { + "input": "Definition: Manufactured form described as a legally binding accord between two or more people that details any and all arrangements regarding a specific situation(s).", + "output": "Transaction counts and value totals - contract (ActInvoiceAdjudicationPaymentSummaryCode)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 11q", + "output": "11q14-q21 (Chromosome band)" + }, + { + "input": "Definition: Diagnostic Techniques, Endocrine described as tests that evaluate the adrenal glands controlled by pituitary hormones.", + "output": "Function Tests, Pituitary-Adrenal (Laboratory Procedure)" + }, + { + "input": "Definition: organonitrogen compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of interleukin-10.", + "output": "interleukin-10 biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: mitochondrion-derived vesicle mediated transport described as transport from the mitochondrion to the peroxisome, mediated by mitochondrion-derived vesicles.", + "output": "mitochondrion to peroxisome transport (mitochondrion-derived vesicle mediated transport)" + }, + { + "input": "Definition: Transportation of Patients described as an emergency vehicle used for transporting patients to a health care facility after injury or illness. Types of ambulances used in the United States include ground (surface) ambulance, rotor-wing (helicopter), and fixed-wing aircraft (airplane).", + "output": "Ambulance, NOS (Motor Vehicles)" + }, + { + "input": "Definition: Cell Function described as the process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana.", + "output": "embryo sac egg cell differentiation (Cell Function)" + }, + { + "input": "Definition: something described as an image of reduced quality resulting from the application of a mask in the wrong way.", + "output": "Inappropriate Manual Collimation (Collimation Error)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13.", + "output": "negative regulation of interleukin-13 biosynthetic process (regulation of interleukin-13 biosynthetic process)" + }, + { + "input": "Definition: Finding described as a supernumerary tissue in addition to normal tissues.", + "output": "Accessory Tissue (Other Finding)" + }, + { + "input": "Definition: Skin, Human described as a melanocytic nevus that contains a variable number of darkly pigmented macules and papules.", + "output": "Nevus Spilus (Benign melanocytic nevus)" + }, + { + "input": "Definition: Professional or Occupational Group described as the head of a body of persons who takes part in an activity.", + "output": "Participant Chief (Professional or Occupational Group)" + }, + { + "input": "Definition: Geographic Area described as an inland sea between Europe and Asia. It is connected with the Aegean Sea by the Bosporus, the Sea of Marmara, and the Dardanelles.", + "output": "Black Sea (Oceans and Seas)" + }, + { + "input": "Definition: something described as the process in which an organic acid is transported across a membrane.", + "output": "organic acid transmembrane transport (Cell Function)" + }, + { + "input": "Definition: Hand deformities described as an abnormal position of the hand in which the wrist is bent toward the radius (i.e., toward the thumb).", + "output": "Radial deviation deform hand (Finding)" + }, + { + "input": "Definition: transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule.", + "output": "C-acyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure.", + "output": "kidney vasculature development (Organ or Tissue Function)" + }, + { + "input": "Definition: Genital and reproductive functions described as mental and physical functions related to the sexual act, including the arousal, preparatory, orgasmic and resolution stages.", + "output": "Sexual Function (Urinary Tract Physiology)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as n-(1-Oxobutyl)-cyclic 3',5'-(hydrogen phosphate)-2'-butanoate guanosine. A derivative of cyclic GMP. It has a higher resistance to extracellular and intracellular phosphodiesterase than cyclic GMP.", + "output": "Cyclic GMP, Dibutyryl (Cyclic GMP)" + }, + { + "input": "Definition: Physical Examination described as a medical inspection, qualified according to the methods employed, as physical examination, radiologic examination, diagnostic imaging examination, etc., performed under conditions of patient's complete or partial local or general insensibility to pain with or without the loss of consciousness, induced by an anesthetic agent or by non-pharmacological anesthesia technique.", + "output": "Examination under anesthesia (Health Care Activity)" + }, + { + "input": "Definition: Intellectual Product described as a standardized 90-item caretaker-report questionnaire developed by Briere et al. in 1999, that utilizes a four-point Likert rating scale to evaluate severity of posttraumatic stress and related symptoms in children ages 3-12 years who have experienced traumatic events.", + "output": "TSCYC (Intellectual Product)" + }, + { + "input": "Definition: cellular polysaccharide biosynthetic process described as the chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides.", + "output": "Lewis a epitope biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: something described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.", + "output": "Stage IV Grade 1 Follicular Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Malignant neoplasm of anal canal described as a very rare tumor of the intestine, originating from the epithelium of the anal canal (including the mucosal surface, anal glands, and lining of fistulous tracts), macroscopically appearing as a nodular, often ulcerated, invasive mass located in the anal canal. Patients often present with rectal bleeding, as well as difficulty and pain during defecation. Inguinal lymphadenopathy, if present, usually indicates metastatic spread.", + "output": "Adenocarcinoma Arising in the Anal Mucosa (Digestive System Neoplasms)" + }, + { + "input": "Definition: General Qualifier described as expressing entrance, or a passing from the outside of a thing to its interior parts.", + "output": "into (Unapproved attribute)" + }, + { + "input": "Definition: Retroviridae described as type C retroviruses that cause leukemia in mice. Includes the Abelson, AKR, Friend, Moloney, Gross, and other leukemia viruses.", + "output": "MURINE LEUKEMIA VIRUS (Gammaretrovirus)" + }, + { + "input": "Definition: something described as a unique, 2-character domain code used in the regulatory submission process. The domain abbreviation is used consistently throughout the submission, i.e. in the dataset name, as the value of the domain variable within the dataset, and as a prefix for most variable names in the dataset.", + "output": "Submission Domain Abbreviation (Idea or Concept)" + }, + { + "input": "Definition: something described as a character or string that represents the short code name of the palpable masses assessment.", + "output": "Palpable Masses Assessment Test Code (Test Code)" + }, + { + "input": "Definition: Globus Pallidus described as the representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.", + "output": "Nucleus pallidus (Basal ganglia and capsules)" + }, + { + "input": "Definition: something described as the part of France situated in Western Europe, including Corsica, as opposed to the overseas departments and territories of the French Republic. Metropolitan France extends from the Mediterranean Sea to the North Sea and from the Rhine River to the Atlantic Ocean.", + "output": "FX (Geographic Area)" + }, + { + "input": "Definition: something described as a non-neoplastic or neoplastic disorder that affects the soft tissue.", + "output": "Soft tissue disorders NOS (Disorder by body site)" + }, + { + "input": "Definition: Merkel Cell Carcinoma pM1 TNM Finding v7 described as merkel cell carcinoma with metastasis to skin, subcutaneous tissues or distant lymph nodes.", + "output": "Merkel Cell Carcinoma pM1a TNM Finding v7 (Merkel Cell Carcinoma pM1 TNM Finding v7)" + }, + { + "input": "Definition: something described as human PKD1 wild-type allele is located in the vicinity of 16p13.3 and is approximately 47 kb in length. This allele, which encodes polycystin-1 protein, is involved in the development of the kidney. Mutations in the gene are associated with polycystic kidney disease autosomal dominant type 1.", + "output": "Polycystin 1 Gene (Gene or Genome)" + }, + { + "input": "Definition: Rare Non-Neoplastic Disorder described as a rare autosomal recessive neurodegenerative disorder caused by mutations in the PLA2G6 gene. It is characterized by the development of swellings called spehroids along the axons of the central nervous system. Signs and symptoms appear early in life and include movement difficulties, muscle hypotonia and spasticity, and dementia.", + "output": "NEUROAXONAL DYSTROPHY, INFANTILE (Cerebral degeneration in childhood)" + }, + { + "input": "Definition: Intellectual Product described as the atomic unit of data transferred between systems. It comprises a group of segments in a defined sequence, each message has a message type that defines its purpose.", + "output": "Data Message (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as cartridge syringes designed to inject dental anesthetics from a changeable, prefilled, disposable, sealed cartridge that includes a needle attached to one end. These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, to lessen the possibility of contact of the healthcare provider with the sharp needle.", + "output": "Syringes, Cartridge, Dental, Anesthetic, Protective (Medical Device)" + }, + { + "input": "Definition: Lesion of neck described as narrowing of the carotid arteries.", + "output": "arteries carotid stenosis (Central nervous system vascular disorders NEC)" + }, + { + "input": "Definition: Pharmacologic Substance described as an antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody against the stem cell factor receptor c-Kit (SCFR) and conjugated, via a non-cleavable linker, to the cytotoxic agent maytansine, with potential antineoplastic activity. The monoclonal antibody moiety of anti c-KIT ADC LOP628 targets and binds to the cell surface antigen c-Kit. After antibody-antigen interaction followed by internalization, the maytansine moiety binds to tubulin, inhibits microtubule assembly, and induces microtubule disassembly. This leads to a disruption of mitosis and the inhibition of cell proliferation in cancer cells expressing c-Kit. c-Kit, a transmembrane protein and receptor tyrosine kinase, is overexpressed in solid tumors and hematological malignancies; it plays a key role in the regulation of cell differentiation and proliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C117735\" active clinical trials using this agent.", + "output": "Anti c-KIT ADC LOP628 (Pharmacologic Substance)" + }, + { + "input": "Definition: Relationships described as specifies the link between a study site and a version of the study protocol used or available for use at that site. NOTE(S): Even if a study site's IRB has not reviewed the study protocol version, if there is a new version for the study protocol, then there is the potential for a relationship between the site and the version. The dateRange is specified only if the version is approved for this site by the IRB and activated at the site. Retroactive approval means that the dateRange does not have to be on or after the IRB approval date.", + "output": "Study Site Protocol Version Relationship (Qualitative Concept)" + }, + { + "input": "Definition: Vascular Endothelial Growth Factor Receptor Measurement described as the determination of the amount of soluble vascular endothelial growth factor receptor 3 present in a sample.", + "output": "Soluble Vascular Endothelial Growth Factor Receptor 3 (Laboratory Procedure)" + }, + { + "input": "Definition: Receptor described as transmembrane sensor receptor proteins that are central components of the chemotactic systems of a number of motile bacterial species which include ESCHERICHIA COLI and SALMONELLA TYPHIMURIUM. Methyl-accepting chemotaxis proteins derive their name from a sensory adaptation process which involves methylation at several glutamyl residues in their cytoplasmic domain. Methyl-accepting chemotaxis proteins trigger chemotactic responses across spatial chemical gradients, causing organisms to move either toward favorable stimuli or away from toxic ones.", + "output": "Chemotaxis Proteins, Methyl-Accepting (Bacterial Proteins)" + }, + { + "input": "Definition: something described as specifies whether a result is considered a biomarker. NOTE(S): This attribute is based on a result as stated in the NCI Thesaurus for Biomarker: A variation in cellular or biochemical components or processes, structures, or functions that is objectively measurable in a biological system and that characterizes normal biologic processes, pathogenic processes, an organism's state of health or disease, likelihood of developing a disease, prognosis, or response to a particular therapeutic intervention. Biomarkers include but not limited to such phenotypic parameters as specific enzyme or hormone concentration, specific gene phenotype, presence or absence of biological substances.", + "output": "Performed Clinical Result Biomarker Indicator (Qualitative Concept)" + }, + { + "input": "Definition: something described as cutaneous mastocytosis, short stature, deafness, microtia, psychomotor retardation, and minor dysmorphic features.", + "output": "skin mastocytosis-hearing loss-mental retardation syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as serology reagents intended to detect and/or identify antigens or serum antibody titers to epidemic parotitis (mumps) virus, an RNA virus of the genus Paramyxovirus, family Paramyxoviridae. This virus is the etiologic agent of epidemic parotitis (also known as mumps), an infection characterized by swelling of one or both parotid glands that may also affect the pancreas, cause inflammation of the testes (orchitis), and affect the ovaries.", + "output": "IVD Test Reagent/Kits, Serology, Virus, Epidemic Parotitis (Medical Device)" + }, + { + "input": "Definition: Blood Physiological Processes described as functions related to the production of blood and all its constituents.", + "output": "hematogenesis (Red blood cell disorder)" + }, + { + "input": "Definition: something described as needles designed for withdrawal and reinfusion of blood from the peripheral circulatory system after processing in an external hemodialysis machine. These devices typically consist of thin-walled needles of appropriate diameter (typically 14 to 19 gauge) and length to be introduced in arteries and veins and connected to the blood line of a dialysis machine. Hemodialysis needles are available either with a single lumen for alternating flow procedures or with two coaxial lumens for simultaneous withdrawal/infusion procedures; they may be used for periodical long-term treatments or for one-time emergency procedures.", + "output": "Hemodialysis Needles (Device associated with haemodialysis systems)" + }, + { + "input": "Definition: Molecular Function described as increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.", + "output": "ubiquitin-protein transferase activator activity (ubiquitin-protein transferase regulator activity)" + }, + { + "input": "Definition: Vitamin described as a family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.", + "output": "vitamin K 1 (Vitamin K [EPC])" + }, + { + "input": "Definition: Regimen Used to Treat Endometrial Carcinoma described as a regimen consisting of everolimus and letrozole that can be used for the treatment of endometrial cancer.", + "output": "Everolimus/Letrozole Regimen (Regimen Used to Treat Endometrial Carcinoma)" + }, + { + "input": "Definition: Immunology procedure described as the determination of the amount of cyclic citrullinated peptide antibody present in a sample.", + "output": "Cyclic Citrullinated Peptide Antibody Measurement (Immunology procedure)" + }, + { + "input": "Definition: Cocaine Dependence described as physical and psychological dependence on the drug cocaine, which is associated with a pattern of episodic use.", + "output": "Cocaine depend-episodic (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Congenital malformation of the urinary system described as remaining collapsed and obliterated urachal tissue between the bladder dome and umbilicus.", + "output": "Urachal remnant (Congenital Abnormality)" + }, + { + "input": "Definition: Cessation described as discontinuation of the use of tobacco in any form.", + "output": "Cessation, Tobacco (Behavior)" + }, + { + "input": "Definition: Organic Chemical described as a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity. Dibenzothiophene is a component of petroleum oils.", + "output": "Dibenzothiophene (Organic Chemical)" + }, + { + "input": "Definition: algorithm described as a time varying function providing causal changes to a system it acts upon.", + "output": "Input Function (algorithm)" + }, + { + "input": "Definition: organic cyclic compound metabolic process described as the chemical reactions and pathways involving aromatic primary alcohol.", + "output": "aromatic primary alcohol metabolic process (cellular aromatic compound metabolic process)" + }, + { + "input": "Definition: Enterocloster described as a species of gram-positive, obligate anaerobic bacteria in the family Clostridiaceae. C. aldenense is indole positive and produces acid from glucose, maltose, mannose, rhamnose, sucrose, trehalose, and xylose but not from cellobiose, esculin, lactose, mannitol, melezitose, raffinose, salicin, sorbitol, or starch. This species does not hydrolyze urea, esculin, starch, or gelatin or reduce nitrate.", + "output": "Enterocloster citroniae (Bacterium)" + }, + { + "input": "Definition: Adaptor Proteins, Signal Transducing described as a nuclear protein, characterized by multiple LXXLL motifs, that modulates activation of gene transcription by STEROID RECEPTORS, and transcriptional repression by NUCLEAR HORMONE RECEPTORS. It positively regulates gene expression of CIRCADIAN CLOCK PROTEINS AND PEPTIDES, including ARNTL TRANSCRIPTION FACTORS and CRYPTOCHROMES.", + "output": "Receptor Interacting Protein, 140 kDa (Nuclear Proteins)" + }, + { + "input": "Definition: Small Intestinal Lymphoma described as a B-cell or T-cell non-Hodgkin lymphoma that arises from the small intestine. Representative examples of B-cell non-Hodgkin lymphoma include diffuse large B-cell lymphoma, MALT lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma. The T-cell non-Hodgkin lymphomas are the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.", + "output": "Primary Small Intestinal Non-Hodgkin's Lymphoma (Small Intestinal Lymphoma)" + }, + { + "input": "Definition: Childhood Cerebral Astrocytoma described as a glioblastoma that occurs during childhood.", + "output": "pediatric glioblastoma multiforme (Neoplastic Process)" + }, + { + "input": "Definition: Organism Function described as the process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.", + "output": "post-embryonic pectoral fin morphogenesis (Organism Function)" + }, + { + "input": "Definition: Protein Metabolism Process described as the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.", + "output": "thymidylate synthase biosynthesis (organonitrogen compound biosynthetic process)" + }, + { + "input": "Definition: Fertilization described as rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis.", + "output": "double fertilization forming two zygotes (Cell Function)" + }, + { + "input": "Definition: something described as turkey rhubarb.", + "output": "turkey rhubarb (Organic Chemical)" + }, + { + "input": "Definition: FACT-BL Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Bladder Version 4 - Emotional Well-Being: I feel sad.", + "output": "FACT-BL Version 4 - I Feel Sad (Intellectual Product)" + }, + { + "input": "Definition: Housing described as a temporary, often makeshift shelter for persons displaced by war, political oppression, or for religious beliefs.", + "output": "Refugee Camps (Sites of Care Delivery)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that modulates the frequency, rate or extent of animal organ morphogenesis.", + "output": "regulation of animal organ morphogenesis (regulation of multicellular organismal development)" + }, + { + "input": "Definition: something described as a capsule designed to be bitten to release the active and/or inert ingredient(s).", + "output": "Biting Cap (capsule)" + }, + { + "input": "Definition: History described as figures or symbols identifying or representing organizations or societies.", + "output": "EMBLEMS INSIGNIA (History)" + }, + { + "input": "Definition: peptidyl-tyrosine modification described as the cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue.", + "output": "peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone (peptide cross-linking)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Most severe Ideation. (Lifetime).", + "output": "C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent - Most Severe Ideation (Intellectual Product)" + }, + { + "input": "Definition: something described as an abnormal concentration or amount of a mineral in the urine. Medically relevant minerals include calcium, phosphorus, potassium, sodium, chloride, magnesium, iron, zinc, iodine, chromium, copper, fluoride, molybdenum, manganese, and selenium. []", + "output": "Abnormal urinary mineral level (Finding)" + }, + { + "input": "Definition: something described as the determination of the number of band eosinophils in a blood sample.", + "output": "Eosinophils Band Form (Eosinophil count procedure)" + }, + { + "input": "Definition: Procedures for reproductive medicine described as the quality of SEMEN, an indicator of male fertility, can be determined by semen volume, pH, sperm concentration (SPERM COUNT), total sperm number, sperm viability, sperm vigor (SPERM MOTILITY), normal sperm morphology, ACROSOME integrity, and the concentration of WHITE BLOOD CELLS.", + "output": "Semen Analyses (Infertility study)" + }, + { + "input": "Definition: Carcinoma in situ of biliary tract described as stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional metastasis. M0: No distant metastasis.", + "output": "Carcinoma in situ of Extrahepatic Bile Ducts (Extrahepatic Bile Duct Neoplasm)" + }, + { + "input": "Definition: Cell Function described as any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.", + "output": "up regulation of cell cycle G1/S phase transition (Cell Function)" + }, + { + "input": "Definition: something described as stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination.", + "output": "Pathologic Stage II Neuroendocrine Carcinoma of the Skin AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as an aggregate QT value based on the measurement of QT intervals from multiple beats within a single ECG. The method of aggregation, which can vary, is typically a measure of central tendency such as the mean.", + "output": "QT Interval, Aggregate (Quantitative Concept)" + }, + { + "input": "Definition: something described as this gene plays a role in the negative regulation of gene transcription.", + "output": "BMZF-2 (Gene or Genome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a peptide derived from cytomegalovirus (CMV) internal matrix protein pp65. CMV pp65 peptide antigen is used in recombinant vaccinia virus as an HLA-A-restricted epitope to produce vaccines and specific CD8+ and CD4+ cell responses against CMV infection, a serious complication of allogeneic bone marrow transplantation (BMT). In BMT, CMV infection may be prevented by passive immunization with donor-derived CMV-pp65-specific T-cell clones if provided early post-BMT. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26640\" active clinical trials using this agent.", + "output": "CMV pp65 Peptide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Opioid screening described as a measurement of the Oxymorphone in a biological specimen.", + "output": "Oxymorphone measurement (Opioid screening)" + }, + { + "input": "Definition: Dynamic lung volume described as the extra volume of air that can be expired with maximum effort beyond the level reached at the end of a normal, quiet expiration. Common abbreviation is ERV.", + "output": "Volumes, Expiratory Reserve (Pulmonary function tests)" + }, + { + "input": "Definition: Chronic disease of immune system described as a blistering disorder characterized by linear deposition of IgA at the dermoepidermal junction.", + "output": "Ben chr bull derm of childhood (Non-Neoplastic Skin Disorder)" + }, + { + "input": "Definition: something described as a cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide. Vaccination with mutant p53 peptide pulsed dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. Many tumor cells overexpress mutant p53 proteins, resulting in the loss of apoptosis regulation and abnormal cell proliferation.", + "output": "dendritic cell vaccine, mutant p53 peptide pulsed (Organic Chemical)" + }, + { + "input": "Definition: something described as o-benzene dicarboxylate.", + "output": "phthalates (Benzoates)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as reflection on and return to past life experiences in order to think about and reintegrate them into present life circumstances. Usually performed in a treatment or intervention setting. Not limited to elderly populations.", + "output": "life review (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Vertebral column described as a habitual positioning of the body with the head and upper back bent forward. []", + "output": "Stooped posture (Movement Disorders)" + }, + { + "input": "Definition: Enzyme described as trypsin-1 (247 aa, ~27 kDa) is encoded by the human PRSS1 gene. This protein is involved in proteolysis.", + "output": "trypsinogen 1 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.", + "output": "down regulation of cytokine secretion (Cell Function)" + }, + { + "input": "Definition: Physiologic Function described as the series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field.", + "output": "magnetoreception, sensory detection of electrical stimulus (detection of electrical stimulus involved in sensory perception)" + }, + { + "input": "Definition: Guide device described as devices designed to simultaneously direct the placement of the drill hole and protect the surrounding tissue.", + "output": "Guides, Drill (Medical Device)" + }, + { + "input": "Definition: something described as infant death due to AIDS", + "output": "Infant Mortality, AIDS (Research Activity)" + }, + { + "input": "Definition: something described as a parameter used for calculations involving mechanical properties. The parameter is measured by using dynamic light scattering to obtain the intensity weighted mean hydrodynamic size of a collection of particles.", + "output": "Z-Average Value (Parameter Value)" + }, + { + "input": "Definition: Orientation described as chirality axis based stereochemistry where, using the Cahn-Ingold-Prelog (CIP) priority rules, the priorities (from highest to lowest) of the substituent atoms exist in a counterclockwise direction.", + "output": "Axial S (Orientation)" + }, + { + "input": "Definition: B7 Antigens described as a costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.", + "output": "Early T Cell Costimulatory Molecule 1 (Lymphocyte antigen)" + }, + { + "input": "Definition: Degenerative disorder described as breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.", + "output": "Skeletal muscle necrosis (pathologic cytolysis)" + }, + { + "input": "Definition: something described as stage I includes: T1, N0, M0. T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. N0: No regional lymph node metastasis. M0: No evidence of distant metastasis.", + "output": "Stage I Differentiated Thyroid Gland Carcinoma 45 Years and Older AJCC v7 (Stage I Differentiated Thyroid Gland Carcinoma AJCC v7)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 AV Block-Second degree Mobitz Type I (Mobitz Type I, CTCAE)" + }, + { + "input": "Definition: response to organic cyclic compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n.", + "output": "response to cycloalkane (Cell Function)" + }, + { + "input": "Definition: Infectious Disease Pathway described as cells have many defenses against viral infection, including intracellular proteins that interfere with viral replication. Just as mammals have evolved defenses against viruses, viruses have evolved countermeasures to defeat cellular defenses. Vif is a viral gene produced by the HIV virus whose molecular function has remained unclear, but many aspects of its behavior have been revealed. Vif proteins are required for the production of infectious viral particles in many cells, acting to repress an intracellular T cell antiviral defense. Vif interacts with viral RNA and may help package viral genomic RNA to form mature virus. Some Vif is also found packaged in virion particles and multimerization of Vif appears to play a role in its activity. CEM15 is a cellular protein that provides an intracellular defense against HIV replication in T cells by acting against Vif. Viruses lacking the Vif gene are only able to replicate in cells lacking CEM15 and expressing CEM15 in cells is sufficient to prevent HIV infection. Although this research partially clarifies the function of Vif in HIV replication, many questions remain to be answered. CEM15 may or may not interact directly with Vif to block its function. Vif has been shown to bind to HIV genomic RNA and CEM15 has homology to cytidine deaminases, enzymes that edit RNA. This homology suggests that CEM15 may itself have an enzyme activity that modifies HIV RNA to render virus non-infectious.", + "output": "HIV-1 Infection Pathway (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of aspyridone B.", + "output": "aspyridone B breakdown (polyketide catabolic process)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.", + "output": "Dosimetry Calculations, Computer-Assisted (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Colorectal Cancer by AJCC v8 Stage described as stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage II Colorectal Cancer AJCC v8 (Colorectal Cancer by AJCC v8 Stage)" + }, + { + "input": "Definition: Raf Kinase Inhibitor described as an orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.", + "output": "B-Raf/VEGFR-2 Inhibitor RAF265 (Pharmacologic Substance)" + }, + { + "input": "Definition: Sixth cranial nerve finding described as an idiopathic syndrome characterized by the formation of granulation tissue in the anterior cavernous sinus or superior orbital fissure, producing a painful ophthalmoplegia.", + "output": "tolosa hunt syndrome (Fourth cranial nerve finding)" + }, + { + "input": "Definition: something described as a severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia.", + "output": "lupus headache (Headache)" + }, + { + "input": "Definition: something described as a radiolabeled antibody-targeted antineoplastic antibiotic consisting of the enediyne antibiotic calicheamicin conjugated with anti-Lewis Y antibody and labeled with indium In 111. In 111 CMD-193 binds to Lewis Y antigen-expressing tumor cells via its antibody moiety and is internalized; subsequently, the calicheamicin moiety binds to the minor groove of tumor cell DNA, causing double-strand DNA breaks, the inhibition of DNA synthesis, and apoptosis. The indium In 111 radiolabel allows the detection of CMD-193 distribution and tumor localization using gamma scintigraphy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62481\" active clinical trials using this agent.", + "output": "Indium In 111-CMD-193 (Pharmacologic Substance)" + }, + { + "input": "Definition: Antineoplastic Antibody-Drug Conjugate described as an antibody-drug conjugate, consisting of the fully human monoclonal antibody CR011 directed against glycoprotein NMB (GPNMB) and conjugated via a cathepsin B-sensitive valine-citrulline (vc) linkage to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, the monoclonal antibody CR011 moiety binds to glycoprotein nmb (GPNMB), expressed on the surfaces of a variety of cancer cell types; upon endocytosis, the synthetic dolastin analogue MMAE is released via enzymatic cleavage into the tumor cell cytosol, where it binds to tubulin and inhibits tubulin polymerization, which may result in G2/M phase arrest and apoptosis. The vc linkage system is highly stable in serum, rendering the cytotoxicity of glembatumumab vedotin specific for GPNMB-positive cells. GPNMB is a transmembrane protein overexpressed on the surfaces of various cancer cell types, including melanoma, breast, and prostate cancer cells.", + "output": "GLEMBATUMUMAB VEDOTIN (Immunologic Factor)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; embolus requiring urgent intervention", + "output": "Grade 4 Atrial fibrillation (Atrial Fibrillation, CTCAE)" + }, + { + "input": "Definition: HL7 Vocabulary Version 2.5 described as a particular category of events regarded as having particular characteristics, qualities, and/or defined similarities.", + "output": "TYPE OF EVENT (Type - attribute)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as nutrition counseling that focuses client on two issues--changing the environment and modifying the client's response to stress to manage nutrition-related behaviors. (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3) strategy", + "output": "Counselling about nutrition using stress management strategy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Mobility as a finding described as a pattern or manner of running, walking, or moving on foot.", + "output": "Gait (Finding)" + }, + { + "input": "Definition: something described as microscopes and accessories are optical instruments used to enlarge images of specimens, preparations, and cultures for medical purposes. Variations of microscopes and accessories (through a change in the light source) used for medical purposes include the following: (1) Phase contrast microscopes, which permit visualization of unstained preparations by altering the phase relationship of light that passes around the object and through the object. (2) Fluorescense microscopes, which permit examination of specimens stained with fluorochromes that fluoresce under ultraviolet light. (3) Inverted stage microscopes, which permit examination of tissue cultures or other biological specimens contained in bottles or tubes with the light source mounted above the specimen.", + "output": "MICROSCOPE, INVERTED STAGE, TISSUE CULTURE (Medical Device)" + }, + { + "input": "Definition: Cardiology information system described as cardiology data management information systems designed to record, process, and display information related to the clinical and administrative management of a patient's hemodynamic status. These systems include hardware and software to collect information from cardiac output units, monitors, and fluid administration devices. Hemodynamic data management systems help physicians establish baseline hemodynamics and manage the prognosis and treatment of patients with abnormal hemodynamic conditions, such as chronic congestive heart failure, hypertension, and during critical care, surgical, or dialysis procedures. The systems may function as stand-alone systems or may be integrated in a hospitalwide data management information system network.", + "output": "Hemodynamic Data Management Systems (Cardiology information system)" + }, + { + "input": "Definition: Methyltransferase inhibitor described as a drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer.", + "output": "Thymidylate Synthetase Inhibitors (Methyltransferase inhibitor)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling.", + "output": "upregulation of abscisic acid mediated signaling (regulation of abscisic acid-activated signaling pathway)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as enzymes acting on peptide bonds. EC 3.4.-", + "output": "Proteinase (Enzyme)" + }, + { + "input": "Definition: Organic Chemical described as alder buckthorn.", + "output": "Rhamnus frangula / alder buckthorn (Homeopathic remedies letter R)" + }, + { + "input": "Definition: Epilepsy, Generalized described as a syndrome characterized by frequent episodes of epilepsy during childhood. The epileptic episodes may be tonic, atonic, myoclonic, or absence seizures. It may be accompanied by mental retardation and behavioral problems.", + "output": "gastaut syndrome (Epilepsy)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism.", + "output": "negative regulation of complement activation, lectin pathway in other organism (Biologic Function)" + }, + { + "input": "Definition: something described as this gene plays a role in both protein catabolism and antigen processing.", + "output": "proteasome subunit \u03b25i (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as a configurable hub for exchanging clinical trial information between applications and systems across the caGRID.", + "output": "caXchange (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in protein phosphorylation and mitosis.", + "output": "AURKC gene (Gene or Genome)" + }, + { + "input": "Definition: Anatomical Abnormality described as any structural anomaly of the tricuspid valve.", + "output": "Abnormality of the tricuspid valve (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as a molecular abnormality indicating rearrangement of the NFKB2 gene.", + "output": "NFKB2 Gene Rearrangement (Gene Rearrangement Abnormality)" + }, + { + "input": "Definition: something described as a substructure of the thalamus. It, the intergeniculate pulvinar and the Nucleus pulvinaris ventralis (Hassler) constitute the inferior pulvinar nucleus ( Jones-1990 ).", + "output": "Nucleus pulvinaris suprabrachialis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Diagnostic, Therapeutic, and Research Equipment described as containers designed to provide an enclosure during the various steps of the sterilization cycle and subsequent storage and transport of sterilized devices. Most of these containers consist of a box with silicone rubber gaskets to seal their lids. The lid and base are held together by latches (some include locks with keys) and are perforated to permit the sterilant to enter; bacterial filters cover the perforations to maintain the sterility of the contents during storage. Surgical instruments are secured in an instrument tray with pegs or dividers and placed, unwrapped, into the sterilization container. Sterilization containers may be also used to return soiled instruments and supplies to the central sterilization service.", + "output": "Sterilisation container (Containers)" + }, + { + "input": "Definition: Tongue part described as an oval body that is located in a tongue papilla and occupies the entire thickness of the epithelium. It is composed of neuroepithelial (sensory) cells, supporting cells, and basal cells. The opening at the apex of the taste bud is called taste pore.", + "output": "Caliculus gustatorius (Chemoreceptor Cells)" + }, + { + "input": "Definition: Finding described as higher intake of caffeine compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)", + "output": "Excessive caffeine intake (Excessive bioactive substance intake)" + }, + { + "input": "Definition: Remote location new client without ICD diagnosis described as using Oriental diagnostic methods in a simple, 10-minute, out-of-office meeting to assess the health status of a new Oriental medicine client and develop an Oriental medicine treatment plan. Use for client/patient assessment and/or history.", + "output": "Simple new 10 minutes in-office Oriental medicine intake (Remote location new client without ICD diagnosis)" + }, + { + "input": "Definition: Gene or Genome described as human KDM7A wild-type allele is located in the vicinity of 7q34 and is approximately 92 kb in length. This allele, which encodes lysine-specific demethylase 7A protein, plays a role in brain development and histone modification.", + "output": "KIAA1718 (KDM7A gene)" + }, + { + "input": "Definition: Abnormal amniotic fluid described as a lower than normal quantity of amniotic fluid in the amniotic sac. Typically associated with an amniotic fluid index (AFI) of less than 5 cm or a single maximum vertical pocket (MVP) of less than 2 cm.", + "output": "oligohydramnios (Amniotic cavity and membrane problem)" + }, + { + "input": "Definition: CDISC SEND Terminology described as a term that is used to indicate a question with permissible values of yes/no/unknown/not applicable.", + "output": "CDISC SDTM Yes No Unknown or Not Applicable Response Terminology (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane.", + "output": "negative regulation of iron ion import across plasma membrane (regulation of iron ion import across plasma membrane)" + }, + { + "input": "Definition: something described as the approximate intake in one day of a polyunsaturated, omega 3 fatty acid with a 22-carbon chain and six cis double bonds.", + "output": "Docosahexaenoic acid estimated intake in 24 hours (Total fat estimated intake in 24 hours)" + }, + { + "input": "Definition: congenital conditions described as abnormal smallness of the lens.", + "output": "Small lens (congenital conditions)" + }, + { + "input": "Definition: Trophoblastic Neoplasms described as a placental disorder characterized by the presence of two populations of chorionic villi: one population which is of unremarkable development and a second one which shows hydropic changes.", + "output": "Hydatidiform Mole, Partial (Hydatidiform Mole)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Aggregatibacter aphrophilus and is beta-lactamase negative.", + "output": "Aggregatibacter aphrophilus, Beta-lactamase Negative (Aggregatibacter aphrophilus)" + }, + { + "input": "Definition: something described as benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit.", + "output": "Supraauricular pit (Periauricular skin pits)" + }, + { + "input": "Definition: something described as molecular assay reagent intended to identify gene variants associated with hereditary pancreatitis, a disorder characterized by recurrent episodes of pancreatic inflammation. Genetic variants at multiple loci have been associated with hereditary pancreatitis. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in hereditary pancreatitis-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Pancreatic Disorder, Pancreatitis (IVD Panels, Human Genetics)" + }, + { + "input": "Definition: Organic Chemical described as an extract of the whole plant Viscum album (mistletoe) with potential biological response modifier (BRM) activity. Mistletoe extract may both stimulate the antitumoral functions of the immune system and have a direct toxic effect on tumor cells.", + "output": "MISTLETOE EXTRACT (Plant or Plant Part Extract)" + }, + { + "input": "Definition: Aminoacidemia described as an increased concentration of leucine in the blood.", + "output": "Leucinosis (Aminoacidemia)" + }, + { + "input": "Definition: something described as the appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "IL-12 production (cytokine production)" + }, + { + "input": "Definition: TRPM3 gene described as human TRPM3 wild-type allele is located in the vicinity of 9q21.12 and is approximately 918 kb in length. This allele, which encodes transient receptor potential cation channel subfamily M member 3 protein, plays a role in calcium transport.", + "output": "Transient Receptor Potential Cation Channel, Subfamily M, Member 3 wt Allele (TRPM3 gene)" + }, + { + "input": "Definition: Organic Chemical described as red root.", + "output": "red root (Organic Chemical)" + }, + { + "input": "Definition: Pulmonary function tests described as the amount of time it takes for exhalation of air to occur.", + "output": "EXPTIME (Finding)" + }, + { + "input": "Definition: something described as the application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.", + "output": "Ischemic Post Conditioning (Therapeutic procedure)" + }, + { + "input": "Definition: DNA Repair described as the repair of DOUBLE-STRAND DNA BREAKS by rejoining the broken ends of DNA to each other directly.", + "output": "End-Joining Repair, DNA (DNA Repair)" + }, + { + "input": "Definition: Finding described as exocrine pancreatic cancer with no evidence of primary tumor.", + "output": "Exocrine Pancreatic Carcinoma pT0 TNM Finding v8 (Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: something described as identifies the patient's risk for apnea using an appropriate sleep apnea risk tool.", + "output": "Assesses risk factors for apnea (Health Care Activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.", + "output": "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as human TTR wild-type allele is located in the vicinity of 18q12.1 and is approximately 7 kb in length. This allele, which encodes transthyretin protein, plays a role in the stabilization and transport of thyroxine and retinol. Mutations in the gene are associated with hyperthyroxinemia and amyloidosis types 1 and 7.", + "output": "CTS1 (Gene or Genome)" + }, + { + "input": "Definition: something described as an indication that BRAF mutation analysis was performed during the study.", + "output": "BRAF Mutation Analysis Was Performed (Finding)" + }, + { + "input": "Definition: something described as calcium-responsive transactivator (396 aa, ~43 kDa) is encoded by the human SS18L1 gene. This protein plays a role in transcriptional activation.", + "output": "SS18-Like Protein 1 (Transcription Regulatory Protein)" + }, + { + "input": "Definition: Gastrointestinal neoplasms NEC described as a benign condition characterized by the presence of peritoneal implants composed of mature glial tissue. It is usually accompanied by an ovarian teratoma.", + "output": "Gliomatosis Peritonei (Gastrointestinal neoplasms malignancy unspecified NEC)" + }, + { + "input": "Definition: Finding described as the presence of xanthine-containing calculi (stones) in the kidneys.", + "output": "Xanthine stones (Finding)" + }, + { + "input": "Definition: something described as proteins prepared by recombinant DNA technology.", + "output": "Recombinant proteins (genetic manipulation)" + }, + { + "input": "Definition: something described as a Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.", + "output": "Advanced Merkel Cell Carcinoma (Advanced Neuroendocrine Carcinoma)" + }, + { + "input": "Definition: Finding described as bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet) []", + "output": "Acral blistering (Finding)" + }, + { + "input": "Definition: something described as quality Of Life Enjoyment And Satisfaction Questionnaire - Taking everything into consideration, during the past week how satisfied have you been with your: Family relationships?", + "output": "QLES1-Family Relationships (Intellectual Product)" + }, + { + "input": "Definition: something described as an involuntary response in the neonate to the feeling of falling or a loud noise characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and flexion of the fingers and toes, that disappears by 4-6 months of age.", + "output": "Reflex, Moro (Primitive reflex)" + }, + { + "input": "Definition: Tumor Necrosis Factor Receptor described as a tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.", + "output": "CD267 Antigen (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as international Physical Activity Questionnaire (August 2002) Short Last 7 Days Self-Administered Format (IPAQ Short Last 7 Days Self-administered Format Version) During the last 7 days, how much time did you spend sitting on a weekday?: minutes per day.", + "output": "IPA0407B (IPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question)" + }, + { + "input": "Definition: Master Protocol described as a type of master protocol designed to evaluate multiple investigational drugs administered as single drugs or as drug combinations in a single disease population. [After FDA DRAFT Guidance: Master Protocols: Efficient Clinical Trial Design Strategies to Expedite Development of Oncology Drugs and Biologics. September 2018 and Woodcock J, LaVange LM. Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both. N Engl J Med. 2017 Jul 6;377(1):62-70.] See also master protocol.", + "output": "Umbrella Protocol (Master Protocol)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.", + "output": "negative regulation of asexual sporulation resulting in formation of a cellular spore (Cell Function)" + }, + { + "input": "Definition: something described as the determination of the amount of the Clostridium difficile species that is considered toxigenic in a biological sample.", + "output": "TOXCDF (Clostridium difficile Measurement)" + }, + { + "input": "Definition: something described as infections caused by bacteria and fungi, general, specified, or unspecified.", + "output": "BACT INFECT MYCOSES (Croatian translation of the Medical Subject Headings)" + }, + { + "input": "Definition: Gene or Genome described as this gene is thought to be involved in transport; however, a function has yet to be elucidated.", + "output": "R-Spondin 3 Gene (Signaling Pathway Gene)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.", + "output": "interstitial cell of Cajal differentiation (intestinal epithelial cell differentiation)" + }, + { + "input": "Definition: Medical Device described as vascular clip appliers designed for application of small atraumatic clips for blood vessel ligature to stop and/or prevent bleeding (i.e., hemostasis). These appliers may include a mechanism for single or multiple insertions of clips; they can be reloaded with new clips to perform more than one surgical procedure. Dedicated reusable clip appliers are used in open surgery on particular anatomic sites (e.g., arteries, scalp vessels); the applied clips may be intended for temporary use during the surgical procedure or as permanent implants.", + "output": "Clip Appliers, Vascular, Reusable (Clip Appliers, Vascular)" + }, + { + "input": "Definition: Endocrine finding described as a finding indicating decreased tissue sensitivity to a hormone.", + "output": "Hormone Resistance (HORMONES, VITAMINS AND RECEPTOR SITES)" + }, + { + "input": "Definition: Musculoskeletal System Finding described as an increase in the amount of osteoblastic surface as compared to a standard or norm.", + "output": "Increased Osteoblastic Surface (Finding)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as a rare partial autosomal monosomy characterised by global development delay, intellectual disability, behavioural abnormalities (hyperactivity, attention deficit and autistic behaviours), brachycephaly and variable facial dysmorphism. Other associated features may include vertebral fusions, mild contractures of knees and elbows, and feeding difficulties during infancy.", + "output": "2p13.2 microdeletion syndrome (Deletion of part of short arm of chromosome 2)" + }, + { + "input": "Definition: L-aspartate transmembrane transport described as the directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.", + "output": "L-aspartate import across plasma membrane (Cell Function)" + }, + { + "input": "Definition: something described as a measurement of the amount of phosphorus being excreted in a biological specimen over a defined amount of time (e.g. one hour).", + "output": "PHOSEXR (Quantitative Concept)" + }, + { + "input": "Definition: Professional Practice described as any group of three or more full-time physicians organized in a legally recognized entity for the provision of health care services, sharing space, equipment, personnel and records for both patient care and business management, and who have a predetermined arrangement for the distribution of income.", + "output": "Group Practice (Health Care Related Organization)" + }, + { + "input": "Definition: Abdominal Neoplasms described as an insidious poorly circumscribed neoplasm arising from the deep soft tissues of the abdomen. It is characterized by the presence of elongated spindle-shaped fibroblasts, collagenous stroma formation, and an infiltrative growth pattern.", + "output": "mesenteric fibromatosis (Neoplastic disease of uncertain behavior)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of three parts of the dorsomedial nucleus of the hypothalamus in the rat as subdivided on the basis of multiple criteria. The others are the anterior part of the dorsomedial hypothalamic nucleus and the ventral part of the dorsomedial hypothalamic nucleus. Functionally the dorsomedial nucleus is part of the hypothalamic periventricular region of the subcortical motor system ( Swanson-2004 ). In the rat and mouse the nucleus is subdivided differently by different authors; see dorsomedial nucleus of the hypothalamus.", + "output": "ventral part of the dorsomedial hypothalamic nucleus (Structure of dorsomedial hypothalamic nucleus)" + }, + { + "input": "Definition: C [Preparations] described as the sodium salt form of cefonicid, a semisynthetic second-generation cephalosporin with antibacterial activity. Cefonicid binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.", + "output": "Cefonicid Monosodium (C [Preparations])" + }, + { + "input": "Definition: Patients described as a child who is receiving long-term in-patient services or who resides in an institutional setting.", + "output": "Children, Institutionalized (Patient or Disabled Group)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as an exotoxin and superantigen, primarily produced by Staphylococcus aureus, that has been documented in some cases of food poisoning. Staphylococcal enterotoxin E activates T cell cytokine production by sequentially binding to antigens on the beta chain of major histocompatibility complex class II molecules outside the peptide-binding groove and the variable region of the T cell receptor beta chain.", + "output": "Staphylococcal enterotoxin E (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: hydro-lyase activity described as catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA.", + "output": "4-methyloct-2-enoyl-CoA hydratase activity (Molecular Function)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version (C-SSRS Lifetime/Recent Version) Have you been thinking about how you might do this? (Past 1 Month).", + "output": "CSS1103B (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: Amino Acid Metabolism, Inborn Errors described as excess of ornithine in the plasma, such as occurs in the genetic disorders gyrate atrophy of choroid and retina and hyperornithinemia-hyperamonemia-homocitrullinuria syndrome.", + "output": "Ornithine-oxo-acid amino acid transferase deficiency (Disorder of ornithine metabolism)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.", + "output": "alpha5beta1, Integrin (Laminin Receptor)" + }, + { + "input": "Definition: something described as a malignant tumor of the liver occurring during childhood.", + "output": "Liver cancer, child primary (Primary Malignant Liver Neoplasm)" + }, + { + "input": "Definition: Intellectual Product described as terminology relevant to the additional descriptions of the test being performed to produce the microscopic result.", + "output": "Microscopic Findings Test Details (CDISC SDTM Terminology)" + }, + { + "input": "Definition: something described as a bourdon gauge flowmeter is a device intended for medical purposes that is used in conjunction with respiratory equipment to sense gas pressure. The device is calibrated to indicate gas flow rate when the outflow is open to the atmosphere.", + "output": "FLOWMETER, NONBACK-PRESSURE COMPENSATED, BOURDON GAUGE (Medical Device)" + }, + { + "input": "Definition: GasLiquidMixture described as a liquid dose form usually presented in a pressurised multi-dose container equipped with an applicator suitable for delivery of a foam consisting of large volumes of gas dispersed in a liquid containing active substance(s).", + "output": "Foam drug form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Eye described as organ with organ cavity, each instance of which is connected to some optic nerve. Examples: There are only two eyeballs, the right and the left eyeballs.", + "output": "EYE (Face)" + }, + { + "input": "Definition: Complete Blood Count described as the number of phagocytes (neutrophils and monocytes-macrophages) in a cubic millimeter of blood. The APC is the sum of the neutrophils (segs and bands), monocytes, and macrophages times one hundredth (1/100) of the white blood cell count.", + "output": "Absolute Phagocyte Count (Complete Blood Count)" + }, + { + "input": "Definition: Bacterium described as a bacterium that is assigned to the genus Streptococcus that is able to facilitate the complete rupturing of red blood cells, thus producing wide, clear, zones around colonies on blood agar plates.", + "output": "Streptococcus.beta-hemolytic (Bacterium)" + }, + { + "input": "Definition: Veins described as the venous trunk which returns blood from the head, neck, upper extremities and chest.", + "output": "Superior vena cava (Vena cava structure)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen described as catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol.", + "output": "4-nitrocatechol 4-monooxygenase activity (monooxygenase activity)" + }, + { + "input": "Definition: Parasitic infection described as infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.", + "output": "cruzi infection trypanosoma (Infection)" + }, + { + "input": "Definition: Radiation-Sensitizing Agents described as a substance used in a type of radiation therapy called boron neutron capture therapy. BPA-F is injected into a vein, and becomes concentrated in tumor cells. The patient then receives radiation treatment with atomic particles called neutrons. The neutrons react with the boron in BPA-F, producing radioactive particles that kill the tumor cells without harming normal cells.", + "output": "Boronophenylalanine-Fructose Complex (Radiation-Sensitizing Agents)" + }, + { + "input": "Definition: Disease or Syndrome described as a viral disorder characterized by SARS (Severe Acute Respiratory Syndrome)-like symptoms caused by MERS-CoV (MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS).", + "output": "Middle East respiratory syndrome (Disorder characterized by fever)" + }, + { + "input": "Definition: Spatial Concept described as physical location of ICAM3_Gene", + "output": "19: 10311307-10305452 (Chromosome 19 Physical Location)" + }, + { + "input": "Definition: Nucleic Acids described as one of two types of nucleic acid made by cells. Ribonucleic acid contains information that has been copied from DNA (the other type of nucleic acid). Cells make several different forms of ribonucleic acid, and each form has a specific job in the cell. Many forms of ribonucleic acid have functions related to making proteins. Ribonucleic acid is also the genetic material of some viruses instead of DNA. Ribonucleic acid can be made in the laboratory and used in research studies.", + "output": "rnas (Nucleic Acids)" + }, + { + "input": "Definition: something described as bearded iris.", + "output": "iris germanica var florentin (Homeopathic remedies letter I)" + }, + { + "input": "Definition: C [Preparations] described as the oil extracted from the root tuber of Curcuma xanthorrhiza. Curcuma xanthorrhiza oil is used primarily in skincare preparations.", + "output": "CURCUMA ZANTHORRHIZA OIL (Natural Products)" + }, + { + "input": "Definition: something described as the minimum deviation (distance from baseline, positive or negative, usually measured in mm) of the ST segment, obtained from a set of measurements of the deviation of the ST segment.", + "output": "Summary (Min) ST Deviation (Quantitative Concept)" + }, + { + "input": "Definition: Mammal described as new World marsupials of the family Didelphidae. Opossums are omnivorous, largely nocturnal and arboreal MAMMALS, grow to about three feet in length, including the scaly prehensile tail, and have an abdominal pouch in which the young are carried at birth.", + "output": "FAMILY DIDELPHIDAE (Didelphimorphia)" + }, + { + "input": "Definition: something described as advises the Director, National Cancer Institute (NCI), and the Director, Division of Extramural Activities, regarding research grant and cooperative agreement applications, contract proposals and concept review relating to basic and clinical sciences, and applied research and development programs of special relevance to the National Cancer Institute. Members and Chairs will be selected on an \"as needed\" basis in response to specific applications, proposals or proposed solicitations to be reviewed. Established by the Director, NCI, September 29, 1995. Currently authorized under 42 U.S. Code 284 (c)(3), Section 405(c)(3) of the Public Health Service Act, as amended. The Panel is governed by the provisions of Public Law 92-463, as amended (5 U.S.C. Appendix 2).", + "output": "NCI Special Emphasis Panel (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as high grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements that is resistant to treatment.", + "output": "Refractory High-Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements (Neoplastic Process)" + }, + { + "input": "Definition: Inflammation Mediators described as chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection. Chemokines act primarily as chemoattractants and activators of specific types of leukocytes. Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system.", + "output": "Cytokines, Chemotactic (Inflammation Mediators)" + }, + { + "input": "Definition: Steroids described as a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures.", + "output": "Pipecurium (Pharmacologic Substance)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 8q", + "output": "8q22 (Chromosome band)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Functional Well-Being: I am enjoying the things I usually do for fun.", + "output": "FAC01526 (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+.", + "output": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity (pentosyltransferase activity)" + }, + { + "input": "Definition: Varicellovirus described as a genus of enveloped, spherical or pleomorphic viruses with a capsid with T=16 icosahedral symmetry and surrounded by amorphous tegument, in the family Herpesviridae. The genome is composed of monopartite, linear double-stranded DNA. Varicelloviruses are found in mammals and cause chickenpox and shingles in humans.", + "output": "Varicellavirus, NOS (Alphaherpesvirinae)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE.", + "output": "chylomicron binding (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized rating scale originally developed by Yellen et al in 1997 and modified by Cella et al in 2002, which includes a 13-item fatigue scale, as well as 13 items from the original FACT-G of the emotional and functional well-being sections. This instrument measures fatigue/tiredness and its impact on daily activities and functioning in a number of chronic diseases.", + "output": "Functional assessment of chronic illness therapy - fatigue questionnaire - version 4 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Pharmacologic Substance described as a nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Riboflavin helps make red blood cells, helps some enzymes work properly, and keeps skin, nails, and hair healthy. It is found in milk, eggs, malted barley, organ meats, yeast, and leafy vegetables. Riboflavin is water-soluble (can dissolve in water) and must be taken in every day. Not enough riboflavin can cause anemia (a low number of red blood cells), mouth sores, and skin problems. Amounts of riboflavin may be higher in the blood of patients with some types of cancer.", + "output": "7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine (OTHER OPHTHALMOLOGICALS IN ATC)" + }, + { + "input": "Definition: Pharmacologic Substance described as an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells.", + "output": "mTOR1/2 Kinase Inhibitor ME-344 (Organic Chemical)" + }, + { + "input": "Definition: Growth Factor Gene described as this gene is involved in cellular differentiation, growth and proliferation.", + "output": "HRG2 (Gene or Genome)" + }, + { + "input": "Definition: something described as a lipophilic copper(II)bis(thiosemicarbazone) labeled with the positron-emitting isotope (61)Cu with hypoxia-selective and radioisotopic activities. With a high membrane permeability and redox potential, (61)Cu-ATSM easily enters and selectively resides in hypoxic cells. The extent of (61)Cu-ATSM retention in tissue is inversely related to the state of tissue oxygenation allowing the quantitation of tissue hypoxia with positron emission tomography (PET).", + "output": "Copper Cu 61-ATSM (Radioconjugate)" + }, + { + "input": "Definition: Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8035\" active clinical trials using this agent.", + "output": "Lip and Oral Cavity Carcinoma Stage III (Neoplastic Process)" + }, + { + "input": "Definition: Quantitative Concept described as minutes times picomoles per liter (area under the curve), divided by milligrams per gram per day (daily dose normalized by body weight).", + "output": "min.pmol/L/(mg/g/d) (Quantitative Concept)" + }, + { + "input": "Definition: Growth hormone receptor antagonist-containing product described as a pegylated, recombinant, human growth hormone (GH) structural analog with GH receptor antagonist activity. As a GH analog, the structure of pegvisomant is similar to that of native GH with the exception of 9 amino acid substitutions. Pegvisomant selectively binds to GH receptors on cell surfaces, interfering with endogenous GH receptor binding and so GH signal transduction. Inhibition of GH signal transduction results in decreased serum concentrations of insulin-like growthfactor-I (IGF-I), and other GH-responsive serum proteins, including IGF bindingprotein-3 (IGFBP-3) and the acid-labile subunit (ALS), and may inhibit the growth of cancers in which IGF-1 is upregulated. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61881\" active clinical trials using this agent.", + "output": "Pegvisomant (Peptides)" + }, + { + "input": "Definition: something described as gastric cancer with tumor invading serosa (visceral peritoneum).", + "output": "Gastric Cancer pT4a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Diagnostic Factor described as comparison of the BLOOD PRESSURE between the BRACHIAL ARTERY and the POSTERIOR TIBIAL ARTERY. It is a predictor of PERIPHERAL ARTERIAL DISEASE.", + "output": "Brachial Index, Ankle (Vascular measure)" + }, + { + "input": "Definition: Organic Chemical described as a radioconjugate composed of the radionuclide fluorine F 18 conjugated to the L-glutamate derivative, (S)-4-(3-fluoropropyl)-L-glutamic acid (FSPG), targeting the cystine/glutamate transporter protein (xCT or SLC7A11), which is a subunit of the transport system xc(-), with potential imaging activity upon positron emission tomography (PET). Upon intravenous administration, the FSPG moiety of BAY94-9392 specifically binds to xCT and BAY94-9392 is subsequently taken up by the cell via xc(-). Upon uptake, xc(-) activity can be assessed and tumor cells can be detected and imaged by PET. System xc(-), a sodium-independent, heterodimeric transporter, mediates the cellular uptake of cystine in exchange for intracellular glutamate at the plasma membrane; although, it will take up glutamate as well. Xc(-) shows increased activity in certain tumor cells compared to normal, healthy cells due to increased metabolic activity in tumor cells; it plays a key role in tumor cell proliferation, progression and chemoresistance as well as in the management of oxidative stress.", + "output": "fluorine F 18 L-glutamate derivative BAY94-9392 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Combined immunodeficiency described as a rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.", + "output": "Eczema+thromb'paenia+imundefic (Hereditary thrombocytopenic disorder)" + }, + { + "input": "Definition: ESRS-A Clinical Classification Question described as extrapyramidal Symptom Rating Scale-Abbreviated - Parkinsonism-Tremor: Lower limbs/feet.", + "output": "ESRSA106 (Intellectual Product)" + }, + { + "input": "Definition: Papillary and Squamous Cell Neoplasms described as a benign epithelial neoplasm characterized by a papillary growth pattern, lack of significant cytologic atypia, and a wart-like appearance.", + "output": "Verrucous papilloma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a congenital abnormality characterized by round or oval shaped defects in the membranous skull vault resulting in non-ossified, honey comb-like areas in the calvaria.", + "output": "CRANIOFENESTRIA (Congenital Abnormality)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual thinks that, without treatment, cancer will spread in one of three patients within ten years.", + "output": "Without treatment, cancer will spread in one of three patients within 10 years (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.", + "output": "negative regulation of turning behavior involved in mating (regulation of turning behavior involved in mating)" + }, + { + "input": "Definition: something described as the aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans.", + "output": "dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome (Genetic Function)" + }, + { + "input": "Definition: Receptor described as tumor necrosis factor receptor superfamily member 13B (293 aa, ~32 kDa) is encoded by the human TNFRSF13B gene. This protein plays a role in cytokine binding and lymphocyte activation.", + "output": "TNFRSF13B (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Kidney Function Tests described as the volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.", + "output": "Rates, Glomerular Filtration (Kidney Function Tests)" + }, + { + "input": "Definition: C-SSRS Baseline/Screening Version Questionnaire Question described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Have you had these thoughts and had some intention of acting on them? (Lifetime).", + "output": "C-SSRS Baseline/Screening Version - Active Suicidal Ideation with Some Intent to Act, without Specific Plan (Intellectual Product)" + }, + { + "input": "Definition: Monitoring, Intraoperative described as the systematic checking of the condition and function of a patient's CENTRAL NERVOUS SYSTEM during the course of a surgical operation.", + "output": "Intraoperative neurophysiologic monitoring (Neurophysiological Monitoring)" + }, + { + "input": "Definition: Conceptual Entity described as insulin resistance is strongly associated with type II diabetes. \"Diabetogenic\" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.", + "output": "Type II Diabetes Mellitus Pathway (Disease Pathway)" + }, + { + "input": "Definition: Cell Function described as any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "positive regulation of fibroblast growth factor production (Cell Function)" + }, + { + "input": "Definition: something described as a cytogenic abnormality that refers to loss of all or part of chromosome 12.", + "output": "Loss of Chromosome 12 (Chromosomal Loss)" + }, + { + "input": "Definition: Finding described as inspection of the region of the anterior surface of the chest and epigastrium reveals a highly or excessively active or hyperkinetic apical impulse.", + "output": "Hyperactive Thoracic Appearance (Chest Pain)" + }, + { + "input": "Definition: BONES OF VERTEBRAL COLUMN described as bones of the spinal column.", + "output": "Set of vertebrae (Bone structure of spine and/or pelvis)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective answer of complete agreement.", + "output": "Completely (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Intima described as innermost layer of the heart, comprised of endothelial cells.", + "output": "ENDOCARDIUM (Body part)" + }, + { + "input": "Definition: something described as any substance that inhibits ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleotide diphosphate precursors for de novo DNA synthesis. Inhibition of ribonucleotide reductase can cause inhibition of DNA synthesis and cell growth.", + "output": "Ribonucleotide Reductase Inhibitor (Enzyme Inhibitor Drugs)" + }, + { + "input": "Definition: Research Techniques described as systematic procedures which are utilized for the manipulation of materials at the nanoscale (i.e., less than 100 nanometers).", + "output": "Nanotechnology Techniques (Laboratory Procedure)" + }, + { + "input": "Definition: Snare instrument described as respiratory tract snares designed to position and tighten fine-gauge, flexible or semirigid, adjustable wire loops around a region of tissue through an endoscope for mechanical or electrosurgical resection and hemostasis. These devices typically consist of a hollow tubular structure (e.g., a cannula), with one or more adjustable wire loops that protrude at the working end. The snare is introduced into the respiratory tract through the working channel of a bronchoscope (or directly through the nose); a mechanism at the proximal end (handle) controls how much wire extends out of the channel and the movement of the sliding cutting loop as the loop is withdrawn into the cannula. The snare loops (e.g., 0.5 and 1 inch/13 and 23 mm size) are made of monofilament or braided wires that are attached at the proximal end to an electrosurgical (usually monopolar) unit that provides circulation of radio-frequency electric current between the isolated metal loop (i.e., acting as an active electrode) and an external neutral electrode to heat the tissues and facilitate resection and cauterization. Endoscopic respiratory tract snares are used mainly for electrosurgical removal of polyps, tumors, and other abnormal tissue from the respiratory tract, but mechanical (cold) resection may be used for small polyps.", + "output": "Snares, Respiratory Tract, Endoscopic (Snare instrument)" + }, + { + "input": "Definition: Carcinogenic Nitrosamine described as a nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.", + "output": "N-ethyl-N-nitroso-ethanamine (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as a type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles.", + "output": "Anterior blepharitis (Disease or Syndrome)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual bruises or bruised easily.", + "output": "I bruise easily (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: cardiac muscle tissue development described as the process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.", + "output": "cardiac impulse conducting system development (Organ or Tissue Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic persistent combined dystonia disorder characterised by slowly progressive severe caudo-rostrally spreading generalised dystonia with prominent facial and oro-mandibular involvement leading to severe anarthria and/or aphonia, swallowing difficulties and gait disturbances. Additional manifestations include slowed horizontal saccades, subclinical epilepsy, photic myoclonus, oral hypertrophic changes (for example gingival or lingual hyperplasia) as well as delayed milestones and cognitive impairment.", + "output": "Dystonia aphonia syndrome (Generalized dystonia)" + }, + { + "input": "Definition: Hematinics described as iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.", + "output": "ferritin (Biologically Active Substance)" + }, + { + "input": "Definition: AVLT-REY Functional Test Question described as the Rey Auditory Verbal Learning TEST (AVLT-REY) List A, Word 11.", + "output": "AVLT-REY - List A Word 11 (AVLT-REY Functional Test Question)" + }, + { + "input": "Definition: something described as ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).", + "output": "Stage III Childhood Hodgkin Lymphoma (Childhood Hodgkin Lymphoma by Ann Arbor Stage)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.", + "output": "Amputation Knives (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 - Physical Well-Being: I have pain.", + "output": "FAC062-I Have Pain (FACT-BRM Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.", + "output": "G protein coupled serotonin receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as the use of a hand-held vibrating device to apply vibration therapy to a specific location of the body.", + "output": "Localized Vibration Therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Plant described as a plant genus of the family LAURACEAE. Members contain cryptofolione, caryachine, grandisin and other compounds. Some PEUMUS species have been reclassified as CRYPTOCARYA.", + "output": "Cryptocarya R.Br. (Lauraceae)" + }, + { + "input": "Definition: Surgical Instruments described as plier-like, handheld, manual instruments with jaws conformed to hold and cut pins or wires. They are typically used during orthopedic surgery to cut wires and/or pins to the needed length as they are being implanted in the patient. Some pin/wire cutters have silicon tips to grip the cut end of the pin or wire so that it does not fly off and can be disposed of safely.", + "output": "Cutters, Pin/Wire (Medical Device)" + }, + { + "input": "Definition: something described as using counseling techniques to assist a client in identifying and managing compulsive religious behavior and to initiate religious balance in his or her life. Service is billed in 15-minute increments.", + "output": "Religious Addiction Prevention (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Domain described as a domain of the Quality of Life in Neurological Disorders that assesses the status of an adult individual's mental health.", + "output": "Neuro-QoL Adult Self-Reported Mental Health Domain (Domain)" + }, + { + "input": "Definition: something described as cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation.", + "output": "CD 106 ANTIGENS (Immunologic Factor)" + }, + { + "input": "Definition: something described as the tumor extends across the midline and the regional lymph nodes may or may not be involved by tumor; or the tumor is unilateral and the contralateral lymph nodes are involved by tumor; or the tumor is in midline and there is bilateral lymph node involvement by tumor.", + "output": "Stage 3 (International Neuroblastoma Staging System)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an insertion of six nucleotides, thymine-guanine-cytosine-guanine-thymine-guanine, between position 2307 and 2308 of the coding sequence of the EGFR gene.", + "output": "ERBB1 c.2307 2308insTGCGTG (EGFR Exon 20 Insertion Mutation)" + }, + { + "input": "Definition: something described as malignant mesothelioma that is amenable to surgical resection.", + "output": "Resectable Malignant Mesothelioma (Resectable Malignant Neoplasm)" + }, + { + "input": "Definition: something described as a chromosome band present on 11q", + "output": "11q13-q14 (Cell Component)" + }, + { + "input": "Definition: Laboratory Procedure described as a system of (usually) epifluorescence light microscopy in which a fine laser beam of light is scanned over the object through the objective lens. This technique is particularly good at rejecting light from outside the plane of focus and so produces higher effective resolution than other microscopy techniques.", + "output": "CONFOCAL MICROSCOPY (Laboratory Procedure)" + }, + { + "input": "Definition: Diagnostic Procedure described as an imaging modality that transforms an x-ray beam's phase shift, caused by the passage of the beam through the object, into variations in intensity which are then used to create images.", + "output": "Phase-Sensitive X-Ray Imaging (Diagnostic Imaging)" + }, + { + "input": "Definition: something described as rivermead Post Concussion Symptoms Questionnaire - Compared with before the accident, do you now suffer from: Forgetfulness, poor memory.", + "output": "RPQ - Forgetfulness, Poor Memory (RPQ Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported - During the last week, has it been easy or hard for you to: Walk more than a mile?", + "output": "PODCI322 (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "output": "regulation of locomotion involved in locomotory behavior (regulation of locomotion)" + }, + { + "input": "Definition: Helicobacter Infections described as infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.", + "output": "Infection, Helicobacter (Helicobacter Infections)" + }, + { + "input": "Definition: something described as invasive intervention indicated", + "output": "Grade 3 Rectal fissure (Rectal Fissure, CTCAE)" + }, + { + "input": "Definition: something described as geriatric Depression Scale Short Form - Do you often get bored?", + "output": "GDS-SF - Often Get Bored (Intellectual Product)" + }, + { + "input": "Definition: Abnormality of systemic vein described as the formation of a thrombus in the renal vein.", + "output": "renal vein thrombosis (Renal vascular and ischaemic conditions)" + }, + { + "input": "Definition: Liver carcinoma described as a term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 7th edition.", + "output": "Hepatocellular Carcinoma by AJCC v7 Stage (Liver carcinoma)" + }, + { + "input": "Definition: Heterocyclic Compounds, 1-Ring described as any of the toxic or carcinogenic chlorinated hydrocarbons that occur as impurities in herbicides.", + "output": "Dioxin (category) (Heterocyclic Compounds)" + }, + { + "input": "Definition: Large Intestinal Wall Tissue described as the layer of areolar tissue situated beneath the mucous membrane in the distal portion of the digestive tract from the small intestine to the anus.", + "output": "Submucosa of large intestine (Organ component of large intestine)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual feels their breast is or was heavy.", + "output": "Does your breast feel heavy (Intellectual Product)" + }, + { + "input": "Definition: Hereditary disorder of the visual system described as syndrome with characteristics of cortical blindness, intellectual deficit and polydactyly. This combination was found in three children of first-cousin parents. The facial features included prominent forehead, short nose, long philtrum and microretrognathia. Two of the three children died of acute gastroenteritis. Growth and psychomotor development were severely delayed.", + "output": "Cortical blindness, intellectual disability, polydactyly syndrome (Polydactyly)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a type of operant conditioning that uses real-time displays of EEG to illustrate brain activity and allow a subject to self-regulate brain EEG activity. The use of low resolution electromagnetic tomography allows neurofeedback directly on deep brain areas and functions.", + "output": "LORETA-EEG-NFB (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as human IL33 wild-type allele is located in the vicinity of 9p24.1 and is approximately 42 kb in length. This allele, which encodes interleukin-33 protein, is involved in cytokine-mediated activation of inflammation.", + "output": "Interleukin 33 wt Allele (IL33 gene)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a sterile freeze dried preparation intended for reconstitution for parenteral use which has been formulated in a manner that would allow liposomes (a lipid bilayer vesicle usually composed of phospholipids which is used to encapsulate an active drug substance, either within a lipid bilayer or in an aqueous space) to be formed upon reconstitution.", + "output": "Lyophilized powder for injectable liposomal suspension (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as the carbamate agent bendiocarb.", + "output": "Bendiocarb (Pesticides)" + }, + { + "input": "Definition: something described as the process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium.", + "output": "protoperithecium formation (reproductive fruiting body development)" + }, + { + "input": "Definition: something described as any cellular process that decreases the frequency, rate or extent of cell death by apoptosis.", + "output": "negative regulation of apoptosis (negative regulation of programmed cell death)" + }, + { + "input": "Definition: Cold Injury described as an injury to the skin and/or its underlying tissues that results from exposure of the affected area to extreme cold.", + "output": "Frostbite, NOS (Cold Injury)" + }, + { + "input": "Definition: Manufactured Object described as specialized hospital facilities which provide intensive care for burn patients.", + "output": "unit burns (Location within hospital premises)" + }, + { + "input": "Definition: OTHER PLAIN VITAMIN PREPARATIONS in ATC described as the 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).", + "output": "pyridoxin (Organic Chemical)" + }, + { + "input": "Definition: Gene Knock-Out Model described as conditional (or inducible) gene knock-out. A transgenic technique. A transgenic animal is constructed such that a gene of interest, or chromosome region, is flanked by recombination-signal sites (eg, loxP). The animal is then crossed to one which carries the specific recombinase (eg, cre) under the control of a conditional, or tissue specific, promoter. Upon treatment of an inducer the recombinase is expressed, promoting recombination between the signal sites and the loss of the intervening gene or chromosome region.", + "output": "Transient Gene Knock-Out Model (Experimental Model of Disease)" + }, + { + "input": "Definition: Cell Wall described as a mucoprotein found in the cell wall of various types of bacteria. It has adjuvant and antitumor activities and has been used to augment the production of lymphokine-activated killer (LAK) cells.", + "output": "Cell Wall Skeleton (Cell Component)" + }, + { + "input": "Definition: Plant described as a genus (formerly part of Rhus genus) of shrubs, vines, or trees that yields a highly allergenic oleoresin which causes a severe contact dermatitis (DERMATITIS, TOXICODENDRON). The most toxic species are Toxicodendron vernix (poison sumac), T. diversilobum (poison oak), and T. radicans (poison ivy). T. vernicifera yields a useful varnish from which certain enzymes (laccases) are obtained.", + "output": "Toxicodendron, NOS (Anacardiaceae)" + }, + { + "input": "Definition: convergent extension involved in organogenesis described as any convergent extension that is involved in notochord morphogenesis.", + "output": "convergent extension involved in notochord morphogenesis (convergent extension involved in gastrulation)" + }, + { + "input": "Definition: THORAX AND CHEST WALL: INCISIONS described as a surgical procedure in which an large incision is made into the chest wall, for the purpose of accessing organs inside the thoracic cavity.", + "output": "thoracotomy (Surgical Procedure by Site or System)" + }, + { + "input": "Definition: Intellectual Product described as the fourth part of the California Verbal Learning Test for Children. After a 20-minute non-verbal task, the child is asked to recall as many words as he or she can from List A.", + "output": "cvlt-c long delay free recall (california verbal learning test, children's version)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the negative regulation of protein synthesis.", + "output": "PROTEIN KINASE, INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-ACTIVATED (Serine/Threonine Protein Kinase Gene)" + }, + { + "input": "Definition: Hepatocyte described as a morphologic finding indicating the presence of Mallory bodies in the liver parenchyma. Mallory bodies are eosinophilic cytoplasmic inclusions in the hepatocytes. They contain filaments and are present in the liver parenchyma of patients with various liver disorders including alcoholic liver disease, Wilson disease, and primary biliary cirrhosis.", + "output": "Mallory's hyalin (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as determining the force a client can exert with his or her full body by applying manual resistance to a body part, region and/or full body to determine the existence of and/or extent of his or her muscle imbalance(s). Service is billed in 15-minute increments.", + "output": "flbdy manl mscl tst ea.15min (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: inward rectifier potassium channel activity described as enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.", + "output": "ATP-activated inward rectifier potassium channel activity (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as a microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease.", + "output": "INSTRUMENT FOR AUTO READER OF OVERNIGHT MICROORGANISM IDENTIFICATION SYSTEM (Medical Device)" + }, + { + "input": "Definition: Muscular Dystrophies, Limb-Girdle described as limb girdle muscular dystrophies due to mutations in the gene for the ALPHA-SARCOGLYCAN or deficiencies in alpha-sarcoglycan due to a mutation in another gene (secondary alpha-sarcoglycanopathy).", + "output": "Limb Girdle Muscular Dystrophy, Type 2D (Disease or Syndrome)" + }, + { + "input": "Definition: disease transmission described as the transmission of a disease from one individual to another.", + "output": "Horizontal Disease Transmission (Pathologic Function)" + }, + { + "input": "Definition: positive regulation of cellular carbohydrate metabolic process described as any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process.", + "output": "positive regulation of plant-type cell wall polysaccharide breakdown (Molecular Function)" + }, + { + "input": "Definition: ticlopidine described as a ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.", + "output": "Clopidogrelum (Platelet aggregation inhibitors excl. heparin)" + }, + { + "input": "Definition: Laboratory Procedure described as an assay technique that uses enzymes, which when bound to the substrate transform into a fluorescent product, to detect the presence of a substance, usually an antigen.", + "output": "FLUORESCENT ENZYME IMMUNOASSAY (Enzyme Immunoassay)" + }, + { + "input": "Definition: something described as a hematocrit measuring device is a system consisting of instruments, tubes, racks, and a sealer and a holder. The device is used to measure the packed red cell volume in blood to determine whether the patient's total red cell volume is normal or abnormal. Abnormal states include anemia (an abnormally low total red cell volume) and erythrocytosis (an abnormally high total red cell mass). The packed red cell volume is produced by centrifuging a given volume of blood.", + "output": "DEVICE, HEMATOCRIT MEASURING (Medical Device)" + }, + { + "input": "Definition: Finding described as decreased concentration of biopterin in the cerebrospinal fluid (CSF). []", + "output": "Low CSF BH4 (Abnormal CSF biopterin level)" + }, + { + "input": "Definition: something described as human NPM1 wild-type allele is located in the vicinity of 5q35 and is approximately 24 kb in length. This allele, which encodes nucleophosmin protein, may be involved in the maintenance of ribosomal structure. Mutation of the gene is associated with acute myelogenous leukemia. This gene can be involved in at least three translocations, t(2;5)(p23;q35) with the ALK gene is associated with non-Hodgkin lymphoma, t(5;17)(q32;q11) with the RARA gene is linked to acute promyelocytic leukemia and t(3;5)(q25.1;q34) with the MLF1 gene is a factor in myelodysplastic syndrome.", + "output": "NPM1 (Gene or Genome)" + }, + { + "input": "Definition: Coronary artery described as the right coronary artery and all of its branches, including the right posterior descending, right posterolateral and acute marginal branches.", + "output": "RIGHT CORONARY ARTERY, RIGHT POSTERIOR DESCENDING, RIGHT POSTERIOLATERAL AND ACUTE MARGINAL BRANCHES (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Finding described as age of subject (in days) at the start of the adjuvant therapy.", + "output": "Age in Days at Adjuvant Therapy Start (Finding)" + }, + { + "input": "Definition: Immunologic Factor described as an immunoglobulin blood product given to the pregnant mother that helps to prevent the Rh negative mother from developing an antibody response to the Rh positive blood cells of the fetus.", + "output": "Human Rho(D) immune globulin (Immunoglobulins)" + }, + { + "input": "Definition: something described as indicates a body mass index of 30 or higher.", + "output": "Body Mass Index Greater than or Equal to 30 (Finding)" + }, + { + "input": "Definition: Disease or Syndrome described as an adenovirus infection that does not respond to treatment.", + "output": "Refractory Adenovirus Infection (Disease or Syndrome)" + }, + { + "input": "Definition: MDM2 Inhibitor described as the tosylate form of milademetan, an orally available MDM2 (murine double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, milademetan binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it has been implicated in cancer cell proliferation and survival.", + "output": "MILADEMETAN TOSYLATE (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a group of cells in the posterior gray column of the spinal cord; it is found only in the cervical segments ( Carpenter-1983 ) lateral to the proper sensory nucleus ( Swanson-2004 ) in lamina V ( Jastrow-2007 ). In the functional model of central nervous system organization it is classified as part of the subcortical somatosensory system ( Swanson-2004 ) (see Models Where It Appears below).", + "output": "reticular nucleus of the spinal cord (subcortical somatosensory system)" + }, + { + "input": "Definition: Finding described as fever with or without constitutional symptoms", + "output": "Grade 1 Cytokine release syndrome (Finding)" + }, + { + "input": "Definition: Hematoma, Subdural described as accumulation of blood in the SUBDURAL SPACE with acute onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.", + "output": "Acute subdural haematoma (Pathologic Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective score of 17 on a perceived exertion scale that ranges from 6: No exertion at all to 20: Maximal exertion.", + "output": "Borg Scale Rating of Perceived Exertion Score 17 (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as devices, usually small, compressed sponges or gauze typically made of cotton or cellulose, that are inserted into the ear canal. They are compressed for ease of insertion; they expand once in place and after the addition of medicated ear drops that can be instilled into the ear canal through the ear wicks. They are used to hold medicine, such as antibiotics or antifungals, within the ear canal for patients with otitis externa. They can also be used to help reduce ear canal swelling or to prevent stenosis of the external ear canal following otic surgery. The wicks are single use and disposal and are intended to be changed frequently.", + "output": "Ear Wicks (Medical Device)" + }, + { + "input": "Definition: Musculoskeletal chest pain described as a condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs.", + "output": "Musculoskeletal chest pain due to rib injury (Musculoskeletal chest pain)" + }, + { + "input": "Definition: Childhood Central Nervous System Teratoma described as an immature teratoma that arises from the central nervous system during childhood.", + "output": "Childhood Central Nervous System Immature Teratoma (Childhood Immature Teratoma)" + }, + { + "input": "Definition: Monimiaceae described as a plant genus of the family MONIMIACEAE. Members contain boldine ALKALOIDS. Some PEUMUS species have been reclassified as CRYPTOCARYA.", + "output": "Peumus (Plant)" + }, + { + "input": "Definition: Nutritional status described as an imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement.", + "output": "undernutrition (Food and Nutrition)" + }, + { + "input": "Definition: Reference Start Time Point described as a point in time that indicates the beginning of a clinical event.", + "output": "Clinical Events Start Timepoint (Temporal Concept)" + }, + { + "input": "Definition: Physiologic Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus.", + "output": "stress response to nickel (stress response to metal ion)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in transcriptional initiation and regulation.", + "output": "General Transcription Factor IIB Gene (Basal transcription factor genes)" + }, + { + "input": "Definition: something described as a measurement of the shellfish mix antigen IgE antibody in a biological specimen.", + "output": "Shellfish Mix Antigen IgE Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: Benign tumor of seminal vesicle described as a leiomyoma that arises from the seminal vesicle.", + "output": "Seminal Vesicle Leiomyoma (Paratesticular Leiomyoma)" + }, + { + "input": "Definition: embryonic axis specification described as the establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo.", + "output": "oral/aboral axis determination (embryonic axis specification)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week how often have you: been interested in the problems of other people?", + "output": "Q-LES-Q - Interested in Problems of People (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: something described as a large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.", + "output": "Locally Advanced Large Cell Neuroendocrine Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy.", + "output": "Suberoyl-3-aminopyridineamide Hydroxamic Acid (Organic Chemical)" + }, + { + "input": "Definition: Muscle of pelvic diaphragm described as a broad, thin muscle originating form the posterior side of the pubis body, spine of the ischium, and pelvic fascia between the pubis and ischium on either side of the pelvis. Both muscles unite and insert at the apex of the coccyx to form the pelvic floor supporting the pelvic viscera and aiding in defecation.", + "output": "Levator Ani (Skeletal muscle structure of pelvis)" + }, + { + "input": "Definition: C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Description of preparatory acts or behaviors.", + "output": "C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent - Description of Preparatory Acts or Behaviors Toward Suicide Attempt (Intellectual Product)" + }, + { + "input": "Definition: Soft tissue sarcomas histology unspecified described as the reemergence of synovial sarcoma after a period of remission", + "output": "Recurrent Synovial Sarcoma (Neoplastic Process)" + }, + { + "input": "Definition: COMPLEMENT COMPONENTS AND FACTORS described as c5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.", + "output": "C5 - Complement component 5 (Complement System Proteins)" + }, + { + "input": "Definition: General chemical forms described as a basic part of a whole. In chemistry, refers to a simple substance that cannot be broken down into smaller parts or changed into another substance. The basic part of an element is an atom, which contains protons, neutrons, and electrons. All atoms of an element have the same number of protons. Examples of elements are hydrogen, carbon, oxygen, nitrogen, and calcium.", + "output": "elements (Chemical categorized by structure)" + }, + { + "input": "Definition: Intellectual Product described as fatigue Severity Scale (FSS) My fatigue prevents sustained physical functioning.", + "output": "FSS - Fatigue Prevents Sustained Physical Functioning (FSS Questionnaire Question)" + }, + { + "input": "Definition: something described as a carcinoma that arises from neuroepithelial tissues of the olfactory epithelium.", + "output": "Experimental Organism Malignant Neuroepithelial Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a chromosome band present on 21q", + "output": "21q21.3 (Cell Component)" + }, + { + "input": "Definition: Virus described as a species of double-stranded, retro-transcribing viruses in the genus Orthohepadnavirus that is naturally capable of infecting the woodchuck Marmota monax.", + "output": "Woodchuck Hepatitis Virus (Hepatitis Viruses)" + }, + { + "input": "Definition: Neurofibromatoses described as a type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)", + "output": "Plexiform Neuromas (Skin, Human)" + }, + { + "input": "Definition: regulation of phosphatidylethanolamine metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process.", + "output": "negative regulation of phosphatidylethanolamine metabolic process (regulation of phosphatidylethanolamine metabolic process)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.", + "output": "physiological response to wounding (biological adaptation to stress)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues.", + "output": "glucuronoxylan formation (glucuronoxylan metabolic process)" + }, + { + "input": "Definition: Disease or Syndrome described as a developmental disorder of the kidney characterized by cystic dilatation of the medullary collecting ducts, resulting in a spongy gross appearance of the kidney. It may be asymptomatic or complicated by hematuria, infections, or renal stones.", + "output": "kidney sponge (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had a problem with urination.", + "output": "Problem with Urination Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a finding about one or more characteristics of nasal cavity and ethmoid sinus cancer, following the rules of the TNM AJCC v7 classification system.", + "output": "Nasal Cavity and Ethmoid Sinus Cancer TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Intellectual Product described as any clinically documented infection not requiring inpatient management.", + "output": "Grade 1 Clinically Documented Infection not Requiring Inpatient Management (Cordonnier Nonmicrobially-Defined Infection)" + }, + { + "input": "Definition: Neoplastic Process described as a benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures.", + "output": "arteriovenous malformations (Soft tissue lesion)" + }, + { + "input": "Definition: Body Mass Index Greater Than or Equal to 23 described as indicates a body mass index measurement greater than 25.", + "output": "Body Mass Index Greater Than 25 (Body Mass Index Greater Than or Equal to 23)" + }, + { + "input": "Definition: Cell Function described as the cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.", + "output": "signaling receptor ligand precursor processing (cellular process)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as cell biology concerned with structure and function of erythrocytes.", + "output": "Red Blood Cell Structure/Function/Metabolism (Cell physiology)" + }, + { + "input": "Definition: Abnormal atrioventricular connection described as anomalous insertion of the chordae tendinae or papillary muscles into the contralateral ventricle in the presence of a ventricular septum defect.", + "output": "Straddling atrioventricular valve (Abnormal atrioventricular connection)" + }, + { + "input": "Definition: something described as a diagrammatic method to test visual acuity, which uses a chart containing 11 lines of Sloan optotypes in varying sizes with the largest located at the top of the chart and decreasing in size toward the bottom of the chart.", + "output": "CHART, VISUAL ACUITY (Visual acuity test equipment)" + }, + { + "input": "Definition: Receptor Gene described as this gene is involved in both endocytosis and protein sorting.", + "output": "LDLR relative with 11 ligand-binding repeats (Receptor Gene)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 3 Months Version - Please check one box to show how you describe your current health.", + "output": "SGRQ0101 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.", + "output": "N-acetylneuraminic lyase activity (oxo-acid-lyase activity)" + }, + { + "input": "Definition: something described as physiologic analyzers designed to determine the area of contact and evaluate the pressure exerted by the whole body or part of it when lying or sitting on a surface. These analyzers typically include sensors to determine the contour of the area of contact and the pressure existing at each point of the interface between the body and the resting surface (e.g., chair, table, bed), an electronic unit to process the information, and a display typically showing in a colored map the areas of contact and the pressure values for each contact point. Body pressure distribution analyzers are used to determine high-pressure areas, determine abnormal positioning of the body while resting on a surface, facilitate selection of appropriate support surfaces and/or cushions, and help in the treatment and prevention of decubitus ulcers. Dedicated analyzers intended to measure the pressure on the body surface while sitting are also available.", + "output": "Body Pressure Distribution Analyzers (Analyzers, Physiologic)" + }, + { + "input": "Definition: Lipids measurement described as the determination of the ratio of total cholesterol compared to high-density lipoprotein type cholesterol present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "Cholesterol to HDL-Cholesterol Ratio Measurement (Lipids measurement)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the hypothenar eminence, i.e., of the muscles on the ulnar side of the palm of the hand (i.e., on the side of the little finger).", + "output": "Abnormality of the hypothenar eminence (Anatomical Abnormality)" + }, + { + "input": "Definition: Primary malignant neoplasm described as an uncommon variant of rhabdomyosarcoma characterized by the presence of whorls of spindle cells forming a storiform pattern. In children it usually arises in the paratesticular region. In adults it usually arises from the deep soft tissues in the head and neck.", + "output": "malignant neoplasm myosarcoma rhabdomyosarcoma spindle cell (Neoplastic Process)" + }, + { + "input": "Definition: Organic Chemical described as one of the two major active isomeric components of the neomycin complex. Neomycin C is approximately half as active as neomycin B.", + "output": "neomycin C (SKIN AND MUCOUS MEMBRANE ANTIBIOTICS)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue.", + "output": "germ cell repulsion (negative chemotaxis)" + }, + { + "input": "Definition: something described as the subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.", + "output": "Myosin Type II (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Rubivirus described as any viral organism that can be assigned to the genus Rubivirus.", + "output": "325 RUBIVIRUS (Rubivirus)" + }, + { + "input": "Definition: something described as imaging plane with transducer at subcostal space (inferior to sternum) oriented along long axis of left ventricle, which includes left ventricle and left atrium, right ventricle and right atrium, ventricular septum, and atrial septum.", + "output": "Subcostal long axis view (Cardiac imaging views)" + }, + { + "input": "Definition: Pharmacologic Substance described as a commercial combination preparation containing guaifenesin and phenylephrine hydrochloride with expectorant and decongestant activities. Guaifenesin works by drawing water into respiratory tracts, thereby reducing adhesiveness and surface tension of mucus as well as increasing hydration of mucus. This reduces the viscosity of mucus and makes the cough more productive. Phenylephrine hydrochloride, a direct-acting sympathicomimetic amine, activates alpha-adrenergic receptors in the nasal mucosa thereby causing vasoconstriction, reduces swelling of nasal mucous membranes and decreases nasal and sinus congestion.", + "output": "Entex (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as devices designed to measure the rate of change of an object's velocity. These devices typically consist of a sensor and transducer, an amplifier, and extension cables for connection to an electronic measuring unit. They work on the principle of seismic mass: this mass is restrained by a spring, and when the transducer case is accelerated, the mass moves relative to the case and exerts a force on the spring. The acceleration is calculated by measuring mass displacement or the mass' force on the spring, converted to an electrical signal. Acceleration transducers are available using strain gauges (e.g., metallic foil, piezoresistive), capacitive elements, and piezoelectric elements. Clinical accelerometers are intended for several purposes, including measuring the acceleration of body parts to assess a patient's mobility and/or activity (alone or as a component of activity monitors and gait analyzers respectively); assess tremor (e.g., in patients with Parkinson's disease); and activate pacemakers according to the patient's position (e.g., upright).", + "output": "accelerometers (Electromechanical Devices)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the DROSHA gene.", + "output": "RNase III Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: establishment or maintenance of apical/basal cell polarity described as any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.", + "output": "establishment or maintenance of epithelial cell apical/basal polarity (Cell Function)" + }, + { + "input": "Definition: Corynebacterium diphtheriae described as any bacterial organism that can be assigned to the species Corynebacterium diphtheriae subspecies intermedius.", + "output": "Corynebac diphtheriae intermed (Corynebacterium diphtheriae)" + }, + { + "input": "Definition: Epithelioid hemangioendothelioma described as a low grade malignant blood vessel neoplasm characterized by the presence of epithelioid endothelial cells, hylanized and myxoid stroma formation, and angiocentricity. It may present as a painful mass. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C114926\" active clinical trials using this agent.", + "output": "Childhood Epithelioid Hemangioendothelioma (Neoplastic Process)" + }, + { + "input": "Definition: Post-Procedure Recovery described as the regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.", + "output": "Passing water (Bladder function)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the practice of nursing in military environments.", + "output": "Nursing, Military (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Health Care Activity described as the completed activity within the context of a given study that represents the abstraction of a medical record.", + "output": "Performed Medical Record Abstraction (Health Care Activity)" + }, + { + "input": "Definition: Electrocardiogram finding described as a finding of stenosis of less than 70 percent reduction in diameter (or 50 percent reduction in cross-sectional area) in a major epicardial vessel, without stenosis of greater than or equal to 70 percent reduction in diameter (or 50 percent reduction in cross-sectional area) in any major epicardial vessel.", + "output": "Insignificant Disease by ECG Finding (Finding)" + }, + { + "input": "Definition: Body Space or Junction described as the four gaps in the skull of a neonate or fetus where the sutures converge. The bulging or depression of the membranous soft spots can be indicative of intracranial fluid buildup or systemic dehydration.", + "output": "fontanelles (Other Embryologic Structure)" + }, + { + "input": "Definition: Patients' organisations and support groups described as groups, organizations, or institutions providing social and emotional support to an individual. Compare SOCIAL NETWORKS and SELF HELP TECHNIQUES.", + "output": "self-help group (Patients' organisations and support groups)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate.", + "output": "iprodione amidohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: something described as this gene plays a role in co-repression and is a molecular marker for a range of malignancies.", + "output": "AT rich interactive domain 4B (Gene or Genome)" + }, + { + "input": "Definition: something described as a provider of service/function that assists participating individuals to make informed decisions about what will work best for them is consistent with their needs and reflects their individual circumstances. Serving as the agent of the individual, the service is available to assist in identifying immediate and long-term needs, developing options to meet those needs and accessing identified supports and services and may include assistance with recruiting, screening, hiring, and training in-home support providers. A family or person-centered planning approach is used. Supports Brokerage offers practical skills training to enable families and individuals to remain independent. Examples of skills training include providing information on recruiting and hiring personal care workers, managing personal care workers and providing information on effective communication and problem solving. The service/function provides sufficient information to assure that individuals understand the responsibilities involved with self-direction and assist in the development of an effective back-up and emergency plan. Plans may elect to fulfill the requirement of this service/function using a self-directed case manager or creating a distinct service. The Supports Brokerage documents the need for assistive services, planning for and documenting the use of excess funds and locating and maintaining services.", + "output": "Agencies; Supports Brokerage (Health Care Related Organization)" + }, + { + "input": "Definition: phosphorus-oxygen lyase activity described as catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.", + "output": "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (phosphorus-oxygen lyase activity)" + }, + { + "input": "Definition: Laboratory Procedure described as the amount of three dimensional space occupied by the effusion fluid.", + "output": "Effusion Volume Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Measuring Instruments, Electric described as measuring instruments designed to measure electric resistivity; a measure of the opposition of a substance to conduct electric charges when a voltage is applied. This parameter is frequently represented by a lowercase rho and typically measured in ohm per meter. Resistivity meters typically consist of electromechanical or more frequently electronic instruments with appropriate leads. Practical instruments usually measure in multiples of ohms (e.g., kilo- or mega-ohm) per meter. Dedicated resistivity meters are used to measure solid materials (either surface or volumetric resistivity) and less frequently liquid resistivity; some are incorporated in testers used in the inspection and/or maintenance of medical devices and other healthcare facility equipment. Combined electronic instruments measuring high electric resistance, resistivity, and/or its inverse, conductivity, are also available.", + "output": "Electrical Resistivity Meters (Measuring Instruments, Electric)" + }, + { + "input": "Definition: something described as a carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor.", + "output": "Non-Small-Cell Type Neuroendocrine Carcinoma of the Ovary (Neoplastic Process)" + }, + { + "input": "Definition: Mobile Health Unit described as mobile medical facilities designed for decontamination of people from chemical agents, including mustard (H agent), nerve agents such as VX and the G series (including tabun [GA] and sarin [GB]), toxic industrial materials, and some biological agents. These facilities typically include separate areas for disposal of contaminated clothes, washing, and redressing; they may include several showerheads, water-heating capacity, decontamination-solution injectors, and a climate-controlled environment. Mobile medical facilities for decontamination provide a rapid solution in the event of massive emergency situations (e.g., chemical or other biohazardous spills) involving individuals potentially contaminated with bloodborne pathogens, chemicals, or other biohazardous substances.", + "output": "Modular Medical Facilities, Mobile, Personnel Shower/Decontamination (Medical Device)" + }, + { + "input": "Definition: CDISC Functional Test Terminology described as test codes of functional test questions associated with the Huntington's Disease Cognitive Assessment Battery (HD-CAB) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "Huntington's Disease Cognitive Assessment Battery Functional Test Test Code (CDISC Functional Test Terminology)" + }, + { + "input": "Definition: something described as the inability of two or more devices to work together.", + "output": "Device-Device Incompatibility (Phenomenon or Process)" + }, + { + "input": "Definition: benzene-containing compound metabolic process described as the chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.", + "output": "para-aminobenzoic acid metabolic process (benzene-containing compound metabolic process)" + }, + { + "input": "Definition: Intellectual Product described as an optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.", + "output": "CD ROM (Compact discs)" + }, + { + "input": "Definition: Infusion or Flow Problem described as problem associated with a delivery overdose of therapeutic agents, such as drugs or fluids being delivered into a device or a patient.", + "output": "Excess Flow or Over-Infusion (Finding)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's swallowing difficulties result in or have resulted in lost income.", + "output": "Swallowing Difficulty Causes Lost Income (Intellectual Product)" + }, + { + "input": "Definition: Finding described as hypopharyngeal cancer with distant metastasis.", + "output": "Hypopharyngeal Carcinoma pM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as human SETX wild-type allele is located in the vicinity of 9q34.13 and is approximately 95 kb in length. This allele, which encodes probable helicase senataxin protein, plays a role in the metabolism of both DNA and RNA. Mutation of the gene is associated with juvenile amyotrophic lateral sclerosis 4 and autosomal recessive spinocerebellar ataxia 1.", + "output": "SETX wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Scanning laser ophthalmoscopy described as a technique of diagnostic imaging of RETINA or CORNEA of the human eye involving the measurement and interpretation of polarizing ELECTROMAGNETIC WAVES such as radio or light waves. It is helpful in the diagnosis of GLAUCOMA; MACULAR DEGENERATION; and other retinal disorders.", + "output": "Polarimetries, Scanning Laser (Scanning laser ophthalmoscopy)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a vessel graft comprised of an artery whose origin remains in place.", + "output": "In Situ Arterial Graft (Transplanted tissue)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with retinopathies, a collection of conditions that involve damage to the retina. Genetic variants at multiple loci have been associated with retinopathy. These reagents are intended to detect mutations in the majority of retinopathy-associated loci simultaneously.", + "output": "Comprehensive Retinopathy Gene Mutation Panel Reagents (Medical Device)" + }, + { + "input": "Definition: something described as a T-regulatory (Treg) cell donor graft that has been partially engineered by depleting all the T-cells and then enriching the graft with infusions of conventional T-cells and Tregs with potential immunomodulating activity. Upon administration of the partially engineered T-regulatory cell donor graft TRGFT-201 following myeloablation, the allograft may induce tolerance in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT) as treatment for hematologic malignancies.", + "output": "TRGFT-201 (Cell)" + }, + { + "input": "Definition: Immunoconjugates described as an immunocytokine of the human monoclonal antibody fragment F16 (scFv) against the extra-domain A1 of tenascin-C fused, via a short 5-amino acid linker, to a recombinant form of the human cytokine interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. The monoclonal antibody portion of the F16-IL2 fusion protein binds to tumor cells expressing the tumor associated antigen (TAA) tenascin-C. In turn, the IL-2 moiety of the fusion protein stimulates natural killer (NK) cells, macrophages and neutrophils and induces T-cell antitumor cellular immune responses thereby selectively killing tenascin-C-expressing tumor cells. In addition, F16-IL2 may potentiate the cytotoxicity of other chemotherapeutic agents. Tenascin-C, a glycoprotein of the extracellular matrix, is expressed in many cancer cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91395\" active clinical trials using this agent.", + "output": "F16-IL2 fusion protein (Pharmacologic Substance)" + }, + { + "input": "Definition: Histamine Antagonists described as the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.", + "output": "buclizine hydrochloride (ANTIVERTIGO PREPARATIONS)" + }, + { + "input": "Definition: General anatomical term described as the part of the rostral portion of the solitary nucleus of the medulla that is involved in taste percetion. It is identified on the basis of connectivity and responsivity to stimulation of taste receptors of the tongue and soft palate. In the human and the macaque it includes the gustatory nucleus, which is located laterally in the rostral portion of the solitary nucleus, and in the prefacial extension of the solitary nucleus. It receives taste afferents from the glossopharyngeal nerve and the intermediate nerve ( Pritchard-2012 ). In the rat it is located in the rostromedial zone of the solitary nucleus ( Swanson-2004 ).", + "output": "sensory system, gustatory (subcortical sensory systems)" + }, + { + "input": "Definition: something described as an enzyme catalyzing the endonucleolytic cleavage of RNA at the 3'-position of a guanylate residue. EC 3.1.27.3.", + "output": "Guanyloribonuclease (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as an immunohistochemical technique used to detect the presence of caspase-3 in a tissue sample.", + "output": "CASP-3 Staining Method (Laboratory Procedure)" + }, + { + "input": "Definition: something described as suture needles designed with appropriate shape and size to thread sutures through the eye tissues to close surgical or traumatic wounds. These devices typically consist of high-quality, stainless steel, curved needles with an eye in one extreme for insertion of the suture and a sharp tip at the other end. Ophthalmic suture needles may have opposite cutting edges that cut tissue (i.e., cutting needles) or tapered tips that pierce tissue without cutting (i.e., tapered needles).", + "output": "Needles, Suture, Ophthalmic (Ophthalmic device)" + }, + { + "input": "Definition: Pathologic Processes described as physical or mental disease that affects or limits the activities of daily living.", + "output": "disabling disease (Pathologic Processes)" + }, + { + "input": "Definition: something described as the person who is designated by the Investigator to order investigational agents on his/her behalf.", + "output": "Ordering Designee (Research Personnel)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Adult Report (PedsQL Neuromuscular Module Version 3.0 Young Adult Report) In the past one month, how much of a problem has this been for you: It is hard to breathe.", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard to Breathe (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as the process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane.", + "output": "postsynaptic neurotransmitter receptor cycle (neurotransmitter receptor cycle)" + }, + { + "input": "Definition: oxygen delivery equipment described as a peak-flow meter for spirometry is a device used to measure a patient's maximum ventilatory flow rate.", + "output": "flow meters peak (oxygen delivery equipment)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a non-specified metabolic screening procedure code. Use associated HCPCS II codes to bill for screening service(s). This code is used for scope-of-practice mapping, not for billing.", + "output": "Non-specified HCPCS II metabolic procedure reference code no charge (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Lung Version 4 - Social/Family Well-Being: I get support from my friends.", + "output": "FAC01610 (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of DNA replication origin binding.", + "output": "upregulation of DNA replication origin binding (Molecular Function)" + }, + { + "input": "Definition: Neoplastic Process described as stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Local and/or regional spread as defined below. T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings. T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes. M0: No distant metastasis.", + "output": "Stage III Endometrial Cancer AJCC v6 (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.", + "output": "ubiquitin-dependent protein catabolic process (modification-dependent protein catabolic process)" + }, + { + "input": "Definition: Cell Function described as the establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.", + "output": "oocyte axis specification (Cell Function)" + }, + { + "input": "Definition: Shoulder described as a major peripheral nerve of the upper limb; it originates as the medial cord of the brachial plexus, and contains fibers from the C8-T1 nerve roots. It functions to supply both sensory and motor innervation to parts of the forearm and hand.", + "output": "N. ulnaris (Structure of posterior cubital region)" + }, + { + "input": "Definition: Anatomy Qualifier described as of or pertaining to a node, any bulge or swelling of an anatomical structure or part.", + "output": "nodal (Anatomy Qualifier)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual has or had taken any nutritional supplements (excluding vitamins).", + "output": "Have Taken Nutritional Supplements Other Than Vitamins (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as an entity that records and enrolls donors of transplantation materials.", + "output": "Transplant Donor Registry (Intellectual Product)" + }, + { + "input": "Definition: ubiquitin-like protein binding described as interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.", + "output": "ubiquitin binding (Molecular Function)" + }, + { + "input": "Definition: negative regulation of cellular amino acid biosynthetic process described as any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process.", + "output": "negative regulation of leucine formation (regulation of leucine biosynthetic process)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of immunoblasts compared to all lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "Lymphocytes, Immunoblastic/Lymphocytes (Laboratory Procedure)" + }, + { + "input": "Definition: ID4 gene described as human ID4 wild-type allele is located in the vicinity of 6p22.3 and is approximately 5 kb in length. This allele, which encodes DNA-binding protein inhibitor ID-4 protein, is involved in the inhibition of basic helix-loop-helix transcription factors.", + "output": "IDB4 (Gene or Genome)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a transferrin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the transferrin (an iron-binding and transporting serum protein) in serum, plasma, and other body fluids. Measurement of transferrin levels aids in the diagnosis of malnutrition, acute inflammation, infection, and red blood cell disorders, such as iron deficiency anemia.", + "output": "TRANSFERRIN, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Gene or Genome described as human COL4A5 wild-type allele is located in the vicinity of Xq22 and is approximately 258 kb in length. This allele, which encodes collagen alpha-5(IV) chain protein, plays a role in the modulation of the conformation of the extracellular matrix. Mutation or deletion of the gene is associated with Alport syndrome.", + "output": "MGC42377 (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as a high pressure liquid chromatography system for clinical use is a device intended to separate one or more drugs or compounds from a solution by processing the mixture of compounds (solutes) through a column packed with materials of uniform size (stationary phase) under the influence of a high pressure liquid (mobile phase). Separation of the solutes occurs either by absorption, sieving, partition, or selective affinity.", + "output": "Detectors, Chromatography, Liquid, Electrochemical (Medical Device)" + }, + { + "input": "Definition: Embryonic Structure described as neural plate (neuroectoderm) is the region of embryonic ectodermal cells, that lies directly above the notochord; during neurulation, it changes shape, so as to produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube from which the brain and spinal cord develops in vertebrate embryos.", + "output": "neural plate/tube (Embryonic Structure)" + }, + { + "input": "Definition: something described as a recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b.", + "output": "Beta Interferon (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Actual Effective Body Tissue Integrity described as extent of regeneration of cells and tissues in an open wound", + "output": "Wound healing status: secondary intention (Actual Effective Body Tissue Integrity)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.", + "output": "upregulation of Golgi to plasma membrane CFTR protein transport (positive regulation of Golgi to plasma membrane protein transport)" + }, + { + "input": "Definition: something described as a melanoma that occurs during childhood.", + "output": "Childhood Melanoma (melanoma)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as a study population that is defined for the purpose of comparison to the treatment group in a controlled trial. In an epidemiological study, a study population that does not have the outcome of interest.", + "output": "Control (Research Design)" + }, + { + "input": "Definition: Intellectual Product described as a question about how often an individual feels sexually attractive in their clothes.", + "output": "Sexually attractive in your clothes (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as subcategory name for the eTMF domain containing a collection site management documents, including communications, tracking, and documents not otherwise specified.", + "output": "Site Mgmt Comm Track (Intellectual Product)" + }, + { + "input": "Definition: antibiotic biosynthetic process described as the chemical reactions and pathways resulting in the formation of monensin A.", + "output": "monensin formation (heterocycle biosynthetic process)" + }, + { + "input": "Definition: Finding described as state of a particular method of treatment, regimen, procedure, medication, etc. of being unsuitable and inadvisable, often because of a likely adverse reaction.", + "output": "Contra-indicated (General Qualifier)" + }, + { + "input": "Definition: Immunologic Factor described as a fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102877\" active clinical trials using this agent.", + "output": "tanibirumab (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Behavior, Animal described as behavior associated with the intake of food.", + "output": "Feeding-Related Behaviors (Organism Function)" + }, + { + "input": "Definition: Polysaccharides, Bacterial described as envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria; some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium; most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.", + "output": "Capsule, Bacterial (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Approval Date described as date protocol that was finalized or approved internally by the sponsor.", + "output": "Protocol Approval Date (Approval Date)" + }, + { + "input": "Definition: Life-cycle form described as the infectious unit of a virus.", + "output": "Virus Particles (Viral Structures)" + }, + { + "input": "Definition: Foot described as the back (or posterior) of the foot in PRIMATES, found behind the ankle and distal to the toes.", + "output": "Heel structure (Heel)" + }, + { + "input": "Definition: hindbrain described as a neural tract which connects the TECTUM MESENCEPHALI and the SPINAL CORD and is involved in head and eye movement coordination.", + "output": "Predorsal bundle of Edinger (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.", + "output": "NAD+ synthetase activity (acid-ammonia (or amide) ligase activity)" + }, + { + "input": "Definition: Disorder of the genitourinary system described as the presence of a fistula affecting the genitourinary system.", + "output": "genitourinary fistula (Urologic Diseases)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of cspyrone B1.", + "output": "cspyrone B1 biosynthesis (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as adjustable-height tables designed to test for syncope by moving the patient through various positions while the patient is strapped to the table (i.e., tilt test). These tables move by electric motors (usually with battery back-up) and are operated by electronically-controlled hand units. The patient is placed on the examination/tilt table in a head up position with the head elevated higher than the feet and legs in a reverse Trendelenburg position. The table is then moved so that the patient is in the head-down position where the head is lower than the feet and legs in the standard Trendelenburg position. Typically, the tables can travel from 70 degrees head up reverse Trendelenburg to 15 degrees head down Trendelenburg in 13 seconds. Adjustable tilt test tables have straps to secure the patient to the table, a foot-board support for when the patient is in the head-up position and removable drop sections to allow for the introduction of imaging and cardiovascular equipment for syncope testing. Sections of the table may also fold-up to offer back support to the patient when the patient is lying on his/her side. Tilt test adjustable examination/treatment tables are used in cardiovascular and neurological diagnostic settings to test patients that experience syncope.", + "output": "Tilt Test Adjustable Examination/Treatment Tables (Medical Device)" + }, + { + "input": "Definition: Recurrent Carcinoma described as the reemergence of carcinoma in any part of the digestive system after a period of remission.", + "output": "Recurrent Gastrointestinal System Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as TAR DNA-binding protein 43 (414 aa, ~45 kDa) is encoded by the human TARDBP gene. This protein is involved in the regulation of both transcription and mRNA splicing.", + "output": "protein TDP-43 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Miscellaneous Molecular Biology Terms described as a gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function.", + "output": "Homologous (Gene or Genome)" + }, + { + "input": "Definition: Molecular Function described as any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.", + "output": "negative regulation of protein desumoylation (negative regulation of proteolysis)" + }, + { + "input": "Definition: ECG Measurement described as an aggregate JT value based on the measurement of JT intervals from multiple beats within a single ECG. The method of aggregation, which can vary, is typically a measure of central tendency such as the mean.", + "output": "JTAG (Quantitative Concept)" + }, + { + "input": "Definition: Finding described as asymptomatic; mild symptoms with no intervention indicated", + "output": "Grade 1 Testosterone deficiency (Finding)" + }, + { + "input": "Definition: positive regulation of fatty acid beta-oxidation described as a serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation.", + "output": "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway (positive regulation of fatty acid beta-oxidation)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91727\" active clinical trials using this agent.", + "output": "Tabalumab (Pharmacologic Substance)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the patient, equipment, and environment are preoperatively prepared to ensure safety during operative or other invasive procedure.", + "output": "Implements protective measures prior to operative or invasive procedure (Safety)" + }, + { + "input": "Definition: Fatigue, CTCAE 3.0 described as fatigue not relieved by rest; limiting instrumental ADL", + "output": "Grade 2 Fatigue (Fatigue, CTCAE 5.0)" + }, + { + "input": "Definition: Organic Chemical described as a water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.", + "output": "Irish moss gelose (Plant Extracts)" + }, + { + "input": "Definition: Personal assessment described as systematic identification of needs of an individual or a group.", + "output": "assessments need (risk and needs assessment)" + }, + { + "input": "Definition: Cell Component described as a leucoplast in which protein is stored.", + "output": "proteinoplast (Cell Component)" + }, + { + "input": "Definition: Infusion Pumps, Multitherapy described as infusion pumps small enough to be worn or carried by patients that are designed to deliver relatively small volumes of liquid medications and other solutions through intravenous (IV), epidural, or subcutaneous routes at pre-established accurate flow rates. These pumps usually consist of a pumping (e.g., peristaltic, syringe-driven) mechanism to move fluid from an internal solution container to the patient; they also include flow controls to select the dose or volume to be infused. The pumps may also include a display showing prompts and/or audible or visual alarms to indicate abnormal conditions. Multitherapy ambulatory pumps are mainly used to administer therapeutic drugs either continuously or intermittently; dedicated ambulatory pumps (both reusable and single-use) intended for administration of particular medications (e.g., analgesics, insulin) are also available.", + "output": "Ambulatory Multitherapy Infusion Pumps (Medical Device)" + }, + { + "input": "Definition: Nucleoside Analog Antiviral [EPC] described as a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Ribavirin is incorporated into viral RNA, thereby inhibiting viral RNA synthesis, inducing viral genome mutations, and inhibiting normal viral replication.", + "output": "Ribavirina (Triazole derivative)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.", + "output": "Chest>Sternum (Body part)" + }, + { + "input": "Definition: HLA Class I Histocompatibility Antigen, A-0201 Alpha Chain Positive described as a laboratory test result indicating the presence of HLA-A*0201 positive cells in a tissue sample.", + "output": "HLA-A*02:01 Positive Cells Present (HLA-A2 Positive Cells Present)" + }, + { + "input": "Definition: program planning, implementation, and evaluation described as assessment of programs in any setting.", + "output": "program evaluation (Evaluation)" + }, + { + "input": "Definition: regulation of transdifferentiation described as any process that activates or increases the frequency, rate or extent of transdifferentiation.", + "output": "upregulation of transdifferentiation (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as the name and version of the CDISC therapeutic area user guide that is being used in the study submission.", + "output": "CTAUG (Name and Version)" + }, + { + "input": "Definition: Lesion of gingivae described as a loss of gum tissue resulting in an exposure of the roots of the teeth.", + "output": "Receding gums (Gingival Recession)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a type of crystallin that has been found in the lens (LENS, CRYSTALLINE) of certain species of MOLLUSCA such as SQUID and OCTOPUS. It is an inactivated form of aldehyde dehydrogenase.", + "output": "omega Crystallin (Crystallins)" + }, + { + "input": "Definition: Professional Organization or Group described as the National Childhood Cancer Foundation is a non-profit organization that serves as the fund-raising foundation, grantee organization, and the fiscal agent for the Children Oncology Group. The Foundation conducts its fundraising and advocacy efforts on behalf of 90% of the children with cancer in North America, receiving federal and non-federal grants and awards to distribute to the member-institutions. Advocacy and public awareness are also parts of the mission of the Foundation.", + "output": "National Childhood Cancer Foundation (Professional Organization or Group)" + }, + { + "input": "Definition: Neoplastic Process described as a hemangioma arising from the skin. It is characterized by the presence of epithelioid endothelial cells.", + "output": "Angiolymphoid hyperplasia with eosinophilia (Benign Neoplasm)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of fulvestrant and ribociclib that may be used in the treatment of hormone receptor (HR)-positive advanced or metastatic breast cancer.", + "output": "Fulvestrant/Ribociclib Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as health hazard arising from exposure to ionizing radiation.", + "output": "radiation hazard (environmental radiation)" + }, + { + "input": "Definition: something described as a plant genus in the ASTERACEAE family.", + "output": "Hawks Beard (Asteraceae)" + }, + { + "input": "Definition: something described as abnormally rapid thoughts with or without abrupt changes from one topic to another.", + "output": "racing thoughts were demonstrated (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: DNA Methylation Regulation described as any process that activates or increases the frequency, rate or extent of DNA methylation.", + "output": "up-regulation of DNA methylation (DNA Methylation Regulation)" + }, + { + "input": "Definition: Akathisia described as a condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.", + "output": "Akathisia, Drug-Induced (Neurotoxicity Syndromes)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 19q", + "output": "19q13.3 (Chromosome band)" + }, + { + "input": "Definition: something described as the formation of a thrombus in the artery as a direct result of an activity associated with vascular access.", + "output": "Acquired Secondary Arterial Thrombosis due to Catheter Complication (Pathologic Function)" + }, + { + "input": "Definition: Code described as a coded value that represents a special handling requirement for the labeled material or object.", + "output": "handlingCode (Intellectual Product)" + }, + { + "input": "Definition: Finding described as life-threatening consequences", + "output": "Grade 4 Burn, CTCAE (Burn, CTCAE)" + }, + { + "input": "Definition: something described as an assessment of the response to the therapy of the non-target enhancing disease.", + "output": "NTERESP (Disease Response)" + }, + { + "input": "Definition: Surgically-Created Structures described as surgically created body opening", + "output": "Stoma site (Operative site)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in spermatogenesis.", + "output": "SPANXN5 (Gene or Genome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cofilin-1 (166 aa, ~19 kDa) is encoded by the human CFL1 gene. This protein plays a role in the modulation of actin polymerization.", + "output": "Cofilin-1 (Actin Depolymerizing Factors)" + }, + { + "input": "Definition: Medical Device described as an endoscope and accessories is a device used to provide access, illumination, and allow observation or manipulation of body cavities, hollow organs, and canals. The device consists of various rigid or flexible instruments that are inserted into body spaces and may include an optical system for conveying an image to the user's eye and their accessories may assist in gaining access or increase the versatility and augment the capabilities of the devices. Examples of devices that are within this generic type of device include cleaning accessories for endoscopes, photographic accessories for endoscopes, nonpowered anoscopes, binolcular attachments for endoscopes, pocket battery boxes, flexible or rigid choledochoscopes, colonoscopes, diagnostic cystoscopes, cystourethroscopes, enteroscopes, esophagogastroduodenoscopes, rigid esophagoscopes, fiberoptic illuminators for endoscopes, incandescent endoscope lamps, biliary pancreatoscopes, proctoscopes, resectoscopes, nephroscopes, sigmoidoscopes, ureteroscopes, urethroscopes, endomagnetic retrievers, cytology brushes for endoscopes, and lubricating jelly for transurethral surgical instruments. This section does not apply to endoscopes that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.", + "output": "Enteroscope (Endoscopes)" + }, + { + "input": "Definition: Cell Adhesion Molecules described as paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.", + "output": "Paxillin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: SKIN, NAILS, HAIR described as nail plate is the horny translucent plate of nail unit.", + "output": "Nail plate (Nail unit structure)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis.", + "output": "positive regulation of primary cell septum biogenesis (Cell Function)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure expressed in gram(s) per gram per period of time equal to twenty-four hours.", + "output": "Kilogram per Kilogram per Day (Quantitative Concept)" + }, + { + "input": "Definition: something described as a species of the family Ranidae (true frogs). The only anuran properly referred to by the common name \"bullfrog\", it is the largest native anuran in North America.", + "output": "Bullfrogs (Amphibian)" + }, + { + "input": "Definition: something described as infusion pumps that are small enough to be worn or carried by patients (i.e., ambulatory) including electronic-controlled mechanisms that are designed to deliver liquids to a patient through intravenous, epidural, or subcutaneous routes from internal reservoirs at pre-established accurate flow rates. Electronic ambulatory infusion pumps typically include a disposable syringe or a disposable, collapsible bag reservoir; a mechanism for propelling the infusate; an electronic flow-control mechanism; and means of displaying alarm conditions and/or user prompts. Pumps using peristaltic mechanisms successively squeeze and release the IV delivery tubing, moving the fluid into the patient catheter. Syringe pumps use a syringe as a drug reservoir, propelling the fluid by forcing the plunger, or piston, into the syringe barrel. Multitherapy electronic ambulatory infusion pumps are usually microprocessor controlled; some models can be programmed to deliver complex infusion regimens. Some pumps (known as \"smart pumps\") include software capable of detecting medication administration errors (i.e., dose error reduction systems) are also available. Many electronic, battery-powered pumps have alarms to indicate high pressure (usually signifying occlusion), near end of infusion, empty reservoir, air in line, system malfunction, unlocked reservoir, and low battery. Most pumps can detect flow errors and electronic malfunctions. Alarm conditions are typically identified on a display integral to the pump and/or by an audible signal. Electronic ambulatory pumps are used mainly by ambulatory patients in hospitals, other healthcare facilities, and at home.", + "output": "Ambulatory Multitherapy Infusion Pumps, Electronic (Medical Device)" + }, + { + "input": "Definition: something described as hyperthermia microwave therapy systems designed for localized heating of malignant tumors up to a few (e.g., three) centimeters deep. These systems typically include a microwave generator (e.g., 430 MHz frequency) and lens applicators.", + "output": "Microwave Therapy Systems, Hyperthermia, Superficial (Microwave Therapy Systems, Hyperthermia)" + }, + { + "input": "Definition: positive regulation of actin filament polymerization described as the initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.", + "output": "actin nucleation (Molecular Function)" + }, + { + "input": "Definition: Protein Sequence Abnormality described as translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein.", + "output": "Truncation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine.", + "output": "single thymine insertion binding (single base insertion or deletion binding)" + }, + { + "input": "Definition: something described as in a lump; as a whole; used to refer to autopsy techniques in which visceral organs are removed in large blocks allowing the prosector to retain a continuity in organ architecture during the subsequent dissection.", + "output": "En Bloc (Functional Concept)" + }, + { + "input": "Definition: something described as the nerve cells in a network that controls the firing patterns (timing, phasing, and intensity) of MOTOR NEURONS resulting in a coordinated activation of muscle cells that produces rhythmic movements such as MASTICATION; LOCOMOTION; RESPIRATION; and PERISTALSIS.", + "output": "Central Pattern Generator Neurons (Cell)" + }, + { + "input": "Definition: Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8 described as stage IVA includes: (T4a, N2, M0, Any G, Tumor location: Any); (T4b, N0-2, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis.", + "output": "Stage IVA Esophageal Squamous Cell Cancer (Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8)" + }, + { + "input": "Definition: Bacterium described as a strain of the VIBRIO CHOLERAE bacteria belonging to serogroup non-O1, infecting humans and other PRIMATES. It is related to VIBRIO CHOLERAE O1, but causes a disease less severe than CHOLERA. Eating raw shellfish contaminated with the bacteria results in GASTROENTERITIS.", + "output": "Nonagglutinating vibrio (Bacterium)" + }, + { + "input": "Definition: Acyltransferase described as an enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride phosphates. It acts only with CoA derivatives of fatty acids of chain length above C-10. Also forms diglyceride phosphates. EC 2.3.1.15.", + "output": "Acyltransferase, Glycerophosphate (Enzyme)" + }, + { + "input": "Definition: something described as increase in eosinophilic cytoplasmic droplets of alpha 2u-globulin in the S2 segment of the proximal tubules in the cortex with exfoliation of cells, an increase in mitotic figures in affected portions of the proximal tubules, tubular basophilia in some cases, and formation of granular casts at the junction of the inner and outer stripes of the medulla.", + "output": "Alpha 2u-Globulin Nephropathy (Experimental Organism Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Common nursing interventions described as managing, preventing and/or treating a patient's hyperglycemic or hypoglycemic condition. Use NAAOS in conjunction with NAAOR. Service is billed in 15-minute increments.", + "output": "Blood sugar management each additional 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as the covalent attachment of a lipid group to the amino terminus of a protein.", + "output": "N-terminal protein lipidation (Molecular Function)" + }, + { + "input": "Definition: something described as using therapeutic infrared light at a depth of up to 10 mm on a client's body part or region to create a heating effect. Service is billed in 15-minute increments.", + "output": "Infrared light therapy each 15 minutes (Phototherapy)" + }, + { + "input": "Definition: something described as the determination of the ratio of leukocytes compared to total cells present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "Leukocytes/Total Cells (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine one or more of a group enzymes that are secreted in the gastrointestinal tract, including a group of aspartate proteinases (i.e., the pepsinogens) and two other aspartate proteinases, cathepsin D and E. These enzymes can be determined using isotopic and nonisotopic immunoassays.", + "output": "IVD Test Reagent/Kits, Immunoassay, Gastrointestinal Enzyme (IVD Test Reagent/Kits, Immunoassay)" + }, + { + "input": "Definition: Gene or Genome described as human TYR wild-type allele is located within 11q14-q21 and is approximately 118 kb in length. This allele, which encodes tyrosinase protein, plays a role in the multi-step biosynthesis of melanin from tyrosine. Allelic variants of the TYR gene cause three different types of oculocutaneous albinism.", + "output": "Tyrosinase (Oculocutaneous Albinism IA) wt Allele (TYR gene)" + }, + { + "input": "Definition: Human Rights described as the theory of the political, economic, and social equality of the sexes and organized activity on behalf of women's rights and interests.", + "output": "Feminism (Human Rights)" + }, + { + "input": "Definition: ribose phosphate metabolic process described as the chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.", + "output": "PRPP metabolic process (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as hemoglobin in the urine that is due to hemolysis from an external cause.", + "output": "Hemolysis Hb-uria,extern,NOS (Abnormal Hematology Test Result)" + }, + { + "input": "Definition: Mobitz Type I, CTCAE described as asymptomatic, intervention not indicated", + "output": "CTCAE Grade 1 AV Block Second Degree M\u00f6bitz Type I (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as st. Ignatius bean.", + "output": "Ignatia amara / strychnos ignatii / Saint Ignatius bean (Homeopathic remedies letter I)" + }, + { + "input": "Definition: Lyase described as enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1.", + "output": "Ammonia Lyase (Carbon-Nitrogen Lyases)" + }, + { + "input": "Definition: Cell Component described as a protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor).", + "output": "iron-sulfur cluster transfer complex location (Cell Component)" + }, + { + "input": "Definition: Physiologic Function described as any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis.", + "output": "response to oscillatory fluid shear stress (Physiologic Function)" + }, + { + "input": "Definition: something described as the set of characteristics by which a thing or person is recognized or known and that constitutes it's individuality or set inclusion.", + "output": "identities (Psychology)" + }, + { + "input": "Definition: MUSCULOSKELETAL FUNCTIONS: GENERAL TERMS described as a person who has had one or more limbs removed by amputation.", + "output": "amputees (Musculoskeletal System Finding)" + }, + { + "input": "Definition: Bacteroides described as any bacterial organism that can be assigned to the species Bacteroides capillosus.", + "output": "Bacteroides capillosus (Genus Pseudoflavonifractor)" + }, + { + "input": "Definition: something described as tumor limited to the uterus.", + "output": "Adenosarcoma pT1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Peripheral nerve of head and neck described as the largest and uppermost of the paravertebral sympathetic ganglia.", + "output": "Superior cervical sympathetic ganglion (Cervical sympathetic ganglion)" + }, + { + "input": "Definition: Target Anatomic Site Portion Code described as a coded value specifying the arrangement or apportionment of the body (or a paired organ) that is a target site for a substance administration. EXAMPLE(S): entire, single, segment, many OTHER NAME(S): NOTE(S):", + "output": "Defined Substance Administration Target Anatomic Site Portion Code (Intellectual Product)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 17p", + "output": "17p13.3 (Cell Component)" + }, + { + "input": "Definition: Neoplastic Process described as an intermediate grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.", + "output": "Non-Functional Pancreatic Neuroendocrine Tumor G2 (Pancreatic Neuroendocrine Tumor G2)" + }, + { + "input": "Definition: Synapses described as a synapse that uses serotonin as a neurotransmitter.", + "output": "serotonergic synapse (Cell Component)" + }, + { + "input": "Definition: Intellectual Product described as inventory of Depressive Symptomatology Clinician-Rated Version (IDS-C) Please circle one response to each item that best describes the patient for the last seven days: Weight (increase) within the last two weeks.", + "output": "IDSC1-Weight (IDS-C Clinical Classification Question)" + }, + { + "input": "Definition: Excretion Rate described as a determination of the amount of albumin being excreted in urine over a defined period of time.", + "output": "Albumin Urine Excretion Rate (Finding)" + }, + { + "input": "Definition: Unmarried person described as indicates a person who has never been married or whose marriages have been annulled.", + "output": "Single, never married (marital history)" + }, + { + "input": "Definition: something described as USP lists as an antineoplastic and an \"adrenocortical suppressant.\"", + "output": "Aminoglutethimid (corticosteroid inhibitor)" + }, + { + "input": "Definition: Cranial Nerves described as the nerve that carries messages from the retina to the brain.", + "output": "optic nerves (Nerve trunk)" + }, + { + "input": "Definition: Endocardium described as endocardium which is continuous with the tunica intima of the superior vena cava, inferior vena cava and the trunk of pulmonary vein.", + "output": "Endocardium of biatrial part of heart (Endocardium)" + }, + { + "input": "Definition: QIDS-C Clinical Classification Question described as quick Inventory of Depressive Symptomatology Clinician-Rated Version (QIDS-C) Please circle one response to each item that best describes the patient for the last seven days: Outlook (self).", + "output": "QIDSC111 (Intellectual Product)" + }, + { + "input": "Definition: regulation of nuclear migration along microtubule described as any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase.", + "output": "regulation of nuclear migration during mitotic telophase (Cell Function)" + }, + { + "input": "Definition: postsynaptic cytoskeleton described as the portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling.", + "output": "cytoskeleton of dendritic spine (postsynaptic cytoskeleton)" + }, + { + "input": "Definition: Disease or Syndrome described as a term that refers to a group of polypoid lesions in the colon and rectum that are characterized by the presence of serrated architecture of the epithelial component. This group includes hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas/polyps.", + "output": "Colorectal Sporadic Serrated Polyp (Polyp of large intestine)" + }, + { + "input": "Definition: Systemic Scleroderma described as a condition in which there are visceral manifestations of systemic sclerosis without any cutaneous findings.", + "output": "Systemic Sclerosis without Skin Involvement (Systemic Scleroderma)" + }, + { + "input": "Definition: Imidazole described as the hydrochloride salt of imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.", + "output": "IMIDAPRIL HYDROCHLORIDE (Pharmacologic Substance)" + }, + { + "input": "Definition: organelle membrane described as the lipid bilayer surrounding a rhoptry.", + "output": "rhoptry membrane (Cell Component)" + }, + { + "input": "Definition: Anaplastic Hemispheric Astrocytoma described as an anaplastic astrocytoma occurring in the temporal lobe.", + "output": "Temporal Lobe Anaplastic Astrocytoma (Neoplastic Process)" + }, + { + "input": "Definition: Skull structure observable described as a measurement of the occlusal plane to the Frankfort horizontal plane.", + "output": "Cant of occlusal plane (Skull structure observable)" + }, + { + "input": "Definition: negative regulation of mRNA metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage.", + "output": "negative regulation of mRNA cleavage (negative regulation of mRNA metabolic process)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify Chlamydophila pneumoniae and/or Chlamydophila psittaci, both bacteria of the family Chlamydiaceae, by detecting specific genetic information of the DNA of one of the target bacteria. These bacteria may cause respiratory infections, mild atypical pneumonia, and/or psittacosis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila pneumoniae/Chlamydophila psittaci, DNA (Medical Device)" + }, + { + "input": "Definition: Reusable Devices described as powered, usually hydraulically operated tools (e.g., spreaders, saws, chisels, cutters) that are used to facilitate access to and removal of entrapped victims of automobile accidents.", + "output": "extrication devices (Reusable Devices)" + }, + { + "input": "Definition: Disease or Syndrome described as a severe acute inflammatory response affecting the hands and feet of individuals with with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course.", + "output": "hand foot syndrome (Dactylitis)" + }, + { + "input": "Definition: Varicella Zoster Virus Infection described as a condition, whose clinical manifestations include intrauterine growth restriction, scarring cicatricial lesion of the limbs, abnormalities of the limbs, microcephaly, chorioretinitis, microphthalmia, cataracts, cortical atrophy, seizures, and evidence of damage to the autonomic nervous system, that is caused by fetal exposure to the varicella zoster virus during the first trimester of pregnancy.", + "output": "Congenital varicella syndrome (Perinatal varicella)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as thyrohyoid ligament, each instance of which is a round elastic cord that forms the posterior margin of some thyrohyoid membrane; it extends from the tip of the superior horn of some thyroid cartilage upward to the tip of the greater horn of some hyoid bone.", + "output": "Ligamentum thyrohyoideum laterale (Structure of thyrohyoid ligament)" + }, + { + "input": "Definition: Operative Surgical Procedures described as an operation to create an opening (a stoma) from an area inside the body to the outside. Colostomy and urostomy are types of ostomies.", + "output": "-ostomy (Kidneys and Urinary System)" + }, + { + "input": "Definition: Body Location or Region described as clusters of neurons in the cerebrospinal trunk grouped on the basis of function. Belonging to motoneuron groups of the subcortical motor system, they are of two types: sympathetic preganglionic pools and parasympathetic preganglionic pools ( Swanson-2004 ).", + "output": "preganglionic autonomic pools (Body Location or Region)" + }, + { + "input": "Definition: Qualitative Concept described as the degree to which data are protected from the risk of accidental or malicious alteration or destruction and from unauthorized access or disclosure.", + "output": "data security (Security - service)" + }, + { + "input": "Definition: something described as the person is not presently married. The marital history is not known or stated", + "output": "unmarried (Marital Status)" + }, + { + "input": "Definition: Finding described as describes a tumor border that is invading the adjacent tissue.", + "output": "Infiltrative Tumor Margin (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as c-1-tetrahydrofolate synthase, cytoplasmic (935 aa, ~102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism.", + "output": "MTHFD1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Gene or Genome described as human CD24 wild-type allele is located in the vicinity of 6q21 and is approximately 2 kb in length. This allele, which encodes signal transducer CD24 protein, is involved in B-cell functional modulation. Elevated expression levels of the wild type allele may indicate early stage cancer.", + "output": "CD24 wt Allele (CD24 gene)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the lysozyme present in a sample.", + "output": "Lysozyme Measurement (White blood cell enzyme activity measurement)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as glutathione S-transferase Mu 1 (218 aa, ~26 kDa) is encoded by the human GSTM1 gene. This protein is involved in the metabolism of small molecules and xenobiotics.", + "output": "GSTM1b-1b (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Health Care Activity described as teaching a parent and/or parents and/or guardian proper preparation and administration techniques for bottle-feeding his or her newborn. Service is billed in 15-minute increments.", + "output": "nwbrn btl-fdng educ.ea.15min (Parenting education and/or skills training)" + }, + { + "input": "Definition: Developmental malformation of branchial arch described as a hereditary disorder caused by mutations in the EYA1 gene, which is characterized by hearing loss, structural defects of the ear, branchial fistulas or cysts, and early, progressive chronic renal failure.", + "output": "Melnick Fraser Syndrome (Ear disorders congenital NEC)" + }, + { + "input": "Definition: peptidyl-diphthamide metabolic process described as the chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue.", + "output": "peptidyl-diphthamide breakdown (cellular catabolic process)" + }, + { + "input": "Definition: Qualitative Concept described as presence of female gonadal tissue or external phenotype.", + "output": "FEMALE (Qualitative Concept)" + }, + { + "input": "Definition: something described as a unit used for measuring substance concentration or/and activity as defined in the literature reference standard for the particular assay method.", + "output": "Assay Unit (Unit of biological and biochemical measurement)" + }, + { + "input": "Definition: something described as an enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis.", + "output": "Alpha DNA polymerase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Pseudomonadaceae described as genus of gram-negative, aerobic bacteria found in soil and water; its organisms occur singly, in pairs or irregular clumps, and sometimes in chains of varying lengths.", + "output": "Azotobacter Beijerinck 1901 (Bacterium)" + }, + { + "input": "Definition: Intellectual Product described as a unique symbol that establishes identity of the product within the context of another product. There are multiple ways in which an identifier can be associated to a product; inherited from MaterilaIdentifier.identifier, the association to ProcessedProduct.identifier, and the association to ProductRelationship.identifier. If there is no context associated with the identifier, then MaterialIdentifier.identifier should be used. However, if the identifier for a product would be different in different context, one of the other identifiers should be used. If the product is used in multiple assemblies, and in each assembly it would be assigned a different identifier, then ProductRelationship.identifier should be used. If a kind of product is produced by different processors, and each processor assigns the product a different identifier, then ProcessedProduct.identifier should be used.", + "output": "ProductRelationship.identifier (Identifier)" + }, + { + "input": "Definition: something described as serology reagents intended to detect antibodies to Borrelia burgdorferi, a species of intracellular bacterium of the family Spirochaetaceae. These bacteria cause Lyme disease (i.e., Lyme borreliosis), acrodermatitis chronica atrophicans, and erythema chronicum migrans; they are typically transmitted by a parasitic tick of the genus Ixodes.", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Borrelia burgdorferi, Antibody (IVD Test Reagent/Kits, Serology, Bacteria, Borrelia burgdorferi)" + }, + { + "input": "Definition: Organic Chemical described as nosode of glanders.", + "output": "Hippozaeninum / glanders nosode (Homeopathic remedies letter H)" + }, + { + "input": "Definition: RAND-36 Questionnaire Question described as RAND 36-Item Health Survey 1.0 (RAND-36) During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health: Had difficulty performing the work or other activities.", + "output": "R3601-Phys Health: Difficulty Performing (Intellectual Product)" + }, + { + "input": "Definition: Uveal Melanoma Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of uveal melanoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.", + "output": "Uveal Melanoma Pathologic Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Health Care Related Organization described as a facility that performs blood collections or apheresis.", + "output": "Blood Products Collection Facility (Clinical Services)" + }, + { + "input": "Definition: something described as a genetic finding indicating that rearrangement of the FGFR3 gene has not been detected in a sample.", + "output": "JKT4 Gene Rearrangement Negative (Rearrangement Negative)" + }, + { + "input": "Definition: Abdominal Infection described as infection of the vulva and the vagina caused by herpes simplex virus.", + "output": "herpetic vulvovaginitis (Herpes NOS)" + }, + { + "input": "Definition: Neoplastic Process described as adenocarcinomas that arise from the nasal cavity and paranasal sinuses and do not resemble salivary gland adenocarcinomas. This category includes intestinal-type and non-intestinal type adenocarcinomas.", + "output": "Sinonasal Adenocarcinoma, Non-Salivary-Type (Sinonasal Adenocarcinoma)" + }, + { + "input": "Definition: Peripheral B-Lymphocyte described as a mature lymphocyte that has entered the peripheral blood system and has been activated into one of several mature B-cell subtypes.", + "output": "Transformed Peripheral B-Lymphocyte (Cell)" + }, + { + "input": "Definition: negative regulation of TOR signaling described as any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.", + "output": "downregulation of TORC1 signaling (negative regulation of TOR signaling)" + }, + { + "input": "Definition: Pharmacologic Substance described as a potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.", + "output": "DENAGLIPTIN (Pharmacologic Substance)" + }, + { + "input": "Definition: Gastritis described as gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.", + "output": "Reactive gastritis (Disease or Syndrome)" + }, + { + "input": "Definition: Disorder of steroid metabolism described as a genetic disorder associated with a mutation in the AR gene, resulting in partial resistance to androgenic hormones.", + "output": "lubs syndrome (Reproductive system hereditary disorder)" + }, + { + "input": "Definition: purine deoxyribonucleotide metabolic process described as the chemical reactions and pathways involving dGTP, guanosine triphosphate.", + "output": "dGTP metabolism (purine deoxyribonucleoside triphosphate metabolic process)" + }, + { + "input": "Definition: something described as abnormally big lacrimal glands.", + "output": "Enlarged lacrimal glands (examination of lacrimal gland)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions in the nuclear receptor binding SET domain protein 1 (NSD1) gene, located in 5q35.2-q35.3, which encodes for a protein whose exact function is unknown. Inherited genetic deletions are present in most patients with Sotos and Weaver syndromes.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion, NSD1 (Medical Device)" + }, + { + "input": "Definition: Occupational Activity described as the process by which an image is acquired by recording light emissions on radiation-sensitive paper.", + "output": "Photographies (Diagnostic Imaging)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Most lethal attempt date.", + "output": "CSS11-Most Lethal Attempt Date (Intellectual Product)" + }, + { + "input": "Definition: biochemical test described as the determination of the amount of beta-hydroxybutyrate present in a sample.", + "output": "BHYXBTR (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: Advanced Adenocarcinoma described as renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.", + "output": "Advanced Renal Cell Carcinoma (Advanced Adenocarcinoma)" + }, + { + "input": "Definition: Intellectual Product described as data management information systems designed to process, organize, and store clinical and administrative information related to radiology departments and imaging centers. These systems can be used for patient registration, result reporting, film library management, order entry, patient tracking, patient scheduling, and other administrative tasks, such as billing and accounting procedures.", + "output": "Information System, Radiologic (Device associated with nuclear medicine systems)" + }, + { + "input": "Definition: EGFR Protein Variant described as an insertion of the amino acid sequence serine-valine-aspartic acid between the aspartic acid at position 770 and the asparagine at position 771 of the epidermal growth factor receptor protein.", + "output": "Receptor Tyrosine-Protein Kinase erbB-1 D770 N771insSVD (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: H4 histone acetyltransferase activity described as catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).", + "output": "histone acetyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether the sexual relationship between an individual and their partner has been satisfying.", + "output": "Have Satisfying Sexual Relationship with Partner (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as a wheelchair component is a device intended for medical purposes that is generally sold as an integral part of a wheelchair, but may also be sold separately as a replacement part. Examples of wheelchair components are the following: Armrest, narrowing attachment, belt, extension brake, curb climber, cushion, antitip device, footrest, handrim, hill holder, leg rest, heel loops, and toe loops.", + "output": "Hillholders, Wheelchair (Medical Device)" + }, + { + "input": "Definition: Immune Response Regulation Pathway described as sequential activation of complement, initiated by antigen-antibody complex and the binding of complement factor C1q to the Fc region of the antibody.", + "output": "Complement Activation Pathway, Classical (Molecular Function)" + }, + { + "input": "Definition: Urine protein test described as a relative measurement (ratio or percentage) of the type I collagen cross-linked C-telopeptides to creatinine in a biological specimen.", + "output": "Type I Collagen X-Linked C-Telopeptides/Creatinine (Urine protein test)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as instructing and training a client to prepare and/or use a Western herb(s) and/or natural substance(s) for therapeutic purposes. Service is billed in 15-minute increments.", + "output": "Western herb and/or natural substance preparation training individual each 15 minutes (Preparing and/or dispensing and/or training services with or without ICD diagnosis)" + }, + { + "input": "Definition: something described as genus of the family Bunyaviridae causing diseases such as hemorrhagic fever, nephropathia epidemica, and Hantavirus Pulmonary Syndrome; first identified during the Korean war; infection is found primarily in rodents and humans; includes the species Hantaan virus.", + "output": "344 HANTANVIRUS (Virus)" + }, + { + "input": "Definition: something described as king crab.", + "output": "Limulus cyclops / king crab (Organic Chemical)" + }, + { + "input": "Definition: something described as clinical chemistry reagents intended to determine the level of lactate in a sample of whole blood in a short period of time, typically several minutes (i.e., rapid tests). Increased levels of lactate in serum are found in hypoxic states (associated with decreased tissue oxygenation), as in shock, hypovolemia, and cardiac failure, and in metabolic states, usually in diseases such as neoplasias and diabetes mellitus.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Whole Blood, Lactate (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as disability Assessment for Dementia - Stay safely at home by himself/herself when needed?", + "output": "DAD01-Stay Safely at Home When Needed (Intellectual Product)" + }, + { + "input": "Definition: Musculoskeletal and connective tissue disorders described as a non-neoplastic or neoplastic disorder that affects muscles and bones.", + "output": "musculoskeletal system disease (other orthopedic disorders)" + }, + { + "input": "Definition: protein-containing complex assembly described as the aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex.", + "output": "NALP1 inflammasome complex formation (protein-containing complex assembly)" + }, + { + "input": "Definition: Amidine-Lyases described as an enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.", + "output": "Lyase, Argininosuccinate (Enzymes)" + }, + { + "input": "Definition: something described as a quinazoline derivative with potential dual antineoplastic activities. Verubulin hydrochloride binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C64782\" active clinical trials using this agent.", + "output": "N-(4-methoxyphenyl)-n,2-dimethylquinazolin-4-amine Hydrochloride (Organic Chemical)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 4 Weeks Version - Over the past 4 weeks, I have had shortness of breath.", + "output": "SGRQ02-I Have Had Shortness of Breath (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)" + }, + { + "input": "Definition: Lobular organ described as one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body.", + "output": "lung structure (Viscera)" + }, + { + "input": "Definition: Classification described as malignancies (SMQ) includes terms for: all types of malignant or unspecified tumors; malignancy related conditions; malignancy related therapeutic and diagnostic procedures; and tumour markers. [Note: Premalignant disorders are in a separate SMQ]. There are ten sub-SMQs which can be used separately or in combination. Malignancies (SMQ) is subdivided into four sub-SMQs: Malignant or unspecified tumours (SMQ); Malignancy related conditions (SMQ); Malignancy related therapeutic and diagnostic procedures (SMQ); and Tumour markers (SMQ). Malignant or unspecified tumours (SMQ) contains all MedDRA terms for malignant or unspecified tumors, which is further subdivided into two separate sub-SMQs: Malignant tumours (SMQ); and Tumours of unspecified malignancy (SMQ). Malignant tumours (SMQ) is subordinated by Haematological malignant tumours (SMQ); and Non-haematological malignant tumours (SMQ). Tumours of unspecified malignancy (SMQ) is subordinated by Haematological tumours of unspecified malignancy (SMQ); and Non-haematological tumours of unspecified malignancy (SMQ).", + "output": "Malignant tumours (Classification)" + }, + { + "input": "Definition: Urogenital system investigation described as endoscopic examination, therapy or surgery of the ureter.", + "output": "Ureteroscopies (Pelvis endoscopy)" + }, + { + "input": "Definition: disorders of peripheral nerve, neuromuscular junction and muscle described as a motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)", + "output": "Bulbar palsy (Disease or Syndrome)" + }, + { + "input": "Definition: positive regulation of biological process described as any process that activates or increases the frequency, rate or extent of asexual reproduction.", + "output": "up-regulation of asexual reproduction (Physiologic Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual pays someone for full-time help.", + "output": "Pay For Full-time Help (Finding)" + }, + { + "input": "Definition: IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question described as international Physical Activity Questionnaire (August 2002) Long Last 7 Days Self-Administered Format (IPAQ Long Last 7 Days Self-Administered Format Version) How much time did you usually spend on one of those days doing vigorous physical activities in your leisure time?: minutes per day.", + "output": "IPA0323B (Intellectual Product)" + }, + { + "input": "Definition: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation described as the process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.", + "output": "monopolar attachment (Cell Function)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as a rare genetic hematologic disorder characterized by bone marrow failure which manifests with aplastic anemia and/or myelodysplasia, associated with hearing/ear abnormalities (such as deafness, labyrinthitis), inherited in an autosomal dominant manner. Caused by heterozygous mutation in the SRP72 gene on chromosome 4q12.", + "output": "Autosomal dominant aplastic anaemia and myelodysplasia (Congenital abnormal shape of inner ear)" + }, + { + "input": "Definition: Advance Directives described as a type of advance directive that gives a person the authority to make decisions for another individual. It becomes active when that person loses the ability to make decisions for him- or herself.", + "output": "PROXY (Advance Directives)" + }, + { + "input": "Definition: Other peripheral vascular disease described as intermittent bilateral attacks of ischemia of the fingers or toes and sometimes of the ears or nose, marked by severe pallor, and often accompanied by paresthesia and pain.", + "output": "phenomenon raynaud's (Joint or joint related complaint)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - During the last 7 days, on how many days did you travel in a motor vehicle like a train, bus, car or tram?: days per week.", + "output": "IPA03-Days Travel in a Motor Vehicle (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as a recombinant, chimeric, human-murine monoclonal antibody directed against the alpha subunit of the interleukin-2 receptor (IL-2R alpha) with immunosuppressant activity. Basiliximab selectively binds to and blocks IL-2R alpha, expressed on the surface of activated T-lymphocytes, thereby preventing interleukin-2 binding and inhibiting the interleukin-2-mediated activation of lymphocytes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52186\" active clinical trials using this agent.", + "output": "Basiliximab-containing product (Immunomodulators)" + }, + { + "input": "Definition: Biologic Function described as any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor.", + "output": "positive regulation of response to macrophage colony-stimulating factor (Biologic Function)" + }, + { + "input": "Definition: something described as clinical usefulness of AJCC response criteria for neoadjuvant chemotherapy in breast cancer. (Keam B, Im SA, Lim Y, Han SW, Moon HG, Oh DY, Cho N, Lee SH, Han W, Moon WK, Kim DW, Kim TY, Park IA, Noh DY. Clinical usefulness of AJCC response criteria for neoadjuvant chemotherapy in breast cancer. Ann Surg Oncol. 2013 Jul;20(7):2242-9.)", + "output": "Keam Breast Cancer 2013 Oncology Response Criteria (Tumor Response Criterion)" + }, + { + "input": "Definition: DNA Viruses described as DNA viruses that have genomes up to several megabases in length and infect primarily single-celled EUKARYOTES.", + "output": "Giruses (DNA Viruses)" + }, + { + "input": "Definition: transcription elongation factor complex described as a transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.", + "output": "cyclin/CDK positive transcription elongation factor complex (Cell Component)" + }, + { + "input": "Definition: Cystic, mucinous AND/OR serous neoplasm described as an adenocarcinoma usually arising from the ovary. It is characterized by the presence of complex micropapillary structures covered by round and cuboidal cells with a high nuclear to cytoplasmic ratio.", + "output": "Micropapillary Serous Carcinoma (Cystadenocarcinoma, Papillary)" + }, + { + "input": "Definition: something described as the area under the moment curve (AUMC) extrapolated to infinity, calculated using the observed value of the last non-zero concentration, divided by the weight.", + "output": "AUMC Infinity Observed Normalized by Weight (Area Under First Moment Curve)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an iron-binding capacity test system is a device intended to measure iron-binding capacity in serum. Iron-binding capacity measurements are used in the diagnosis and treatment of anemia.", + "output": "FERROZINE (COLORIMETRIC) IRON BINDING CAPACITY (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Mechanoreceptors described as rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin. Pacinian corpuscles contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers. They have large receptive fields and are most sensitive to high-frequency stimuli, such as vibration.", + "output": "Pacini's corpuscle (Mechanoreceptors)" + }, + { + "input": "Definition: something described as a measurement of the prolymphocytes in a biological specimen.", + "output": "prolymphocyte count (Laboratory Procedure)" + }, + { + "input": "Definition: Adenosine Triphosphatases described as DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.", + "output": "MutL Proteins (DNA Repair Enzymes)" + }, + { + "input": "Definition: something described as small forceps with scissorlike handles, used to grasp, hold, and exert traction or compression on a specimen during dissection. Their blades are typically finely pointed and serrated. They are generally used in surgery and oncology.", + "output": "Dissection forceps (Medical Device)" + }, + { + "input": "Definition: something described as a very rare secondary neonatal autoimmune disease characterized by onset of hemolytic anemia in the neonatal period associated with a positive direct antiglobulin test. Hepatosplenomegaly may be associated.", + "output": "Neonatal autoimmune haemolytic anaemia (Autoimmune hemolytic anemia)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the number of mismatch between the study subject and his or her donor for the human leukocyte antigen, class I, group A (HLA-A).", + "output": "HLAAMSC (HLA Mismatch Count)" + }, + { + "input": "Definition: something described as penile cancer with a finding of noninvasive verrucous carcinoma. Note: Broad pushing penetration (invasion) is permitted; destructive invasion is against this diagnosis.", + "output": "Penile Cancer pTa TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as cervical cancer confined to uterus (extension to corpus should be disregarded).", + "output": "Cervical Cancer cT1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as a rare genetic non-acquired combined pituitary hormone deficiency disorder with characteristics of panhypopituitarism (with or without adrenocorticotropic hormone deficiency) associated with spine abnormalities, including frequent rigid cervical spine and short neck with limited rotation and variable degrees of sensorineural hearing loss. The anterior pituitary gland is usually abnormal (typically hypoplastic) and rarely a mild developmental delay or intellectual disability may be associated. There is evidence this disease is caused by homozygous mutation in the LHX3 gene on chromosome 9q34.", + "output": "Non-acquired combined pituitary hormone deficiency, sensorineural hearing loss, spine abnormalities syndrome (Panhypopituitarism)" + }, + { + "input": "Definition: Amyloidosis, Familial described as a group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease.", + "output": "familial Mediterranean fever (Familial non-neuropathic amyloidosis)" + }, + { + "input": "Definition: CPTAC Questions described as a question about whether tumor regression is present.", + "output": "Is Tumor Regression Present (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (71 aa, ~8 kDa) is encoded by the human GNG2 gene. This protein plays a role in G protein GTPase activity.", + "output": "G Gamma-I (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Gene or Genome described as human CXCL16 wild-type allele is located in the vicinity of 17p13 and is approximately 6 kb in length. This allele, which encodes C-X-C motif chemokine 16 protein, may play a role in lymphocyte chemotaxis and scavenger receptor for oxidized low density lipoprotein.", + "output": "CXCL16 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's certainty that they can avoid smoking when they are feeling depressed.", + "output": "Refrain from Smoking when Depressed (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as acetate of potash.", + "output": "kali aceticum/potasssium ace (Homeopathic remedies letter K)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire - During the past week, how often have you: Made repairs or taken care of household maintenance as needed?", + "output": "Q-LES-Q - Made Repairs or Household Maintenance (Intellectual Product)" + }, + { + "input": "Definition: something described as a region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin.", + "output": "C zone (Cell Component)" + }, + { + "input": "Definition: Medical Device described as a gas liquid chromatography system for clinical use is a device intended to separate one or more drugs or compounds from a mixture. Each of the constituents in a vaporized mixture of compounds is separated according to its vapor pressure. The device may include accessories such as columns, gases, column supports, and liquid coating.", + "output": "COLUMNS, GLC (Medical Device)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the amino acid residue at position 250 in the fibroblast growth factor receptor 3 protein where lysine has been replaced by glutamic acid.", + "output": "Tyrosine Kinase JKT4 Lys650Glu (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the megakaryocytes to total cells in a biological specimen (for example a bone marrow specimen).", + "output": "Megakaryocyte to Total Cell Ratio Measurement (Bone Marrow Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Malignant neoplasm of gallbladder described as cancer that forms in tissues of the gallbladder. The gallbladder is a pear-shaped organ below the liver that collects and stores bile (a fluid made by the liver to digest fat). Gallbladder cancer begins in the innermost layer of tissue and spreads through the outer layers as it grows.", + "output": "GALLBLADDER CARCINOMA (Infrequent Neoplasm)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any regimen that can be used for the treatment of mastocytosis.", + "output": "Regimen Used to Treat Mastocytosis (Chemo/immuno/hormone Therapy Regimen)" + }, + { + "input": "Definition: Neoplastic Process described as an invasive adenocarcinoma characterized by cystic changes and the presence of malignant glandular cells which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, appendix, and lung.", + "output": "Pseudomucinous Adenocarcinoma (Cystadenocarcinoma, Mucinous)" + }, + { + "input": "Definition: Supranuclear gaze palsy described as a rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson's syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease.", + "output": "Steele-Richardson-Olszew syndr (Degenerative Diseases, Central Nervous System)" + }, + { + "input": "Definition: Finding described as any line of sutures that deviates from its normal anatomical location.", + "output": "ABNORMAL SUTURE (Abnormal Finding)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Calibration described as reagents intended to establish points of reference (i.e., calibrate) in immunoassay tests performed to determine either one or more of a group of gastrointestinal hormones (e.g., vasoactive intestinal polypeptide). These reagents may be either specific for calibration of a gastrointestinal hormone or, more frequently, appropriate to calibrate a whole set of similar gastrointestinal hormones.", + "output": "IVD Test Reagent/Kits, Immunoassay, Calibration, Gastrointestinal Hormone (Medical Device)" + }, + { + "input": "Definition: Finding described as asymptomatic, intervention not indicated", + "output": "Grade 1 Vasculitis, CTCAE (Finding)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a type 2 angiotensin receptor.", + "output": "AT2 receptor binding (Angiotensin II Receptor Binding)" + }, + { + "input": "Definition: something described as the sudden cessation of cardiac activity in an individual who becomes unresponsive, without normal breathing and no signs of circulation. Cardiac arrest may be reversed by CPR, and/or defibrillation, cardioversion or cardiac pacing.", + "output": "SCA (Hypermagnesemia Severity)" + }, + { + "input": "Definition: Medical Device described as rectum tubes designed to deliver water and sterile or therapeutic solutions (i.e., enemas) into the rectum. These devices typically consist of a single-lumen rubber or plastic (e.g., silicon) tube of 14 to 30 French diameter, about 10 cm (4 inches) long that is inserted through the anus into the rectum. Enema rectum tubes are connected to an enema tip attached to external tubing that runs from an external reservoir (i.e., enema bag) using gravity; dedicated enema tubes for barium delivery are also available.", + "output": "Tubes, Rectal, Enema (Flatus tube)" + }, + { + "input": "Definition: Puberty and gonadal disorders described as an early onset of puberty, in this case early does not refer to precocious.", + "output": "Early onset of sexual maturation (Finding)" + }, + { + "input": "Definition: something described as the region between the inner and outer lipid bilayers of a chloroplast envelope.", + "output": "chloroplast envelope lumen (plastid intermembrane space)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a beta-3 adrenergic receptor.", + "output": "beta-3 adrenergic receptor binding (adrenergic receptor binding)" + }, + { + "input": "Definition: albuterol described as a combination of albuterol and ipratropium with a bronchodilatory effect. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'- adenosine monophosphate (cAMP). This results in the relaxation of bronchial smooth muscle, relieve of bronchospasms, and reduction of inflammatory cell mediator release. Ipratropium is a synthetic quaternary ammonium compound and a competitive muscarinic acetylcholine (Ach) receptor antagonist. This agent inhibits vagally mediated reflexes by antagonizing the action of Ach and consequently, prevents the increase in intracellular cyclic guanosine monophosphate, which is a result of ACh interacting with the muscarinic receptor on bronchial smooth muscle.", + "output": "salbutamol+ipratropium (Asthma Preparation)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate, or extent of glial cell apoptotic process.", + "output": "regulation of glial cell apoptotic process (Cell Function)" + }, + { + "input": "Definition: Functional Concept described as any intended, protocol-defined activity involving data collection from a study subject.", + "output": "Planned Trial Subject Contact (Event)" + }, + { + "input": "Definition: polyol transmembrane transporter activity described as enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol.", + "output": "glucosylglycerol transmembrane transporter activity (carbohydrate transmembrane transporter activity)" + }, + { + "input": "Definition: Cercopithecidae described as a pale brown macaque, Macaca mulatta.", + "output": "Rhesus Macaques (Mammal)" + }, + { + "input": "Definition: Surface Antigens described as a group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.", + "output": "TRANSPL ANTIGENS (GENERAL ANTIGENS AND ANTIGENIC PHENOMENA)" + }, + { + "input": "Definition: something described as abnormality of the nail.", + "output": "Nail abnormality NOS (Anatomical Abnormality)" + }, + { + "input": "Definition: Epithelial Differentiation described as a microscopic finding indicating the presence of cells with glandular differentiation in a tumor sample.", + "output": "Glandular differentiation (Pathology procedure)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual feels or felt unusual fatigue.", + "output": "Have you felt unusually tired or fatigued in the last week (Findings-Based Question)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in cell cycle control.", + "output": "CDK11 (Cyclin-Dependent Kinase Gene)" + }, + { + "input": "Definition: Bowel/Gastric Component described as actions performed to control changes in the stomach or intestines", + "output": "rnax provide gastric care (rnax actions concerning bowel/gastric elimination)" + }, + { + "input": "Definition: something described as a gene change in the body's reproductive cells (egg or sperm) that becomes incorporated into the DNA of every cell in the body of offspring; germline mutations are passed on from parents to offspring.", + "output": "germ-line mutation (Mutation Abnormality)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Lymphoma Version 4 (FACT-LYM Version 4) Additional Concerns: I have emotional ups and downs.", + "output": "FAC01841 (Intellectual Product)" + }, + { + "input": "Definition: Hematology staining procedure described as a cytochemical staining technique using the alpha-naphthyl esterase staining method or a nonspecific esterase staining method to identify and quantify monoblasts and monocytes and to detect esterase activity. The esterase enzyme contained within monocytes and macrophages reacts strongly with the substrate alpha-naphthyl butyrate. The test is useful in diagnosis of acute leukemias. It marks immature monocytes, and thus is useful in the diagnosis of acute myelogenous leukemia of monocytic type.", + "output": "Alpha Naphthyl Esterase Stain (Special Histology Staining Method)" + }, + { + "input": "Definition: something described as RAND Social Support Survey Instrument - How often is each of the following kinds of support available to you if you need it: Someone who shows you love and affection.", + "output": "RSSS01-Shows You Love and Affection (RAND Social Support Survey Questionnaire Question)" + }, + { + "input": "Definition: Chest Pain in Sternum described as the location of the chest pain is in the middle of the sternum.", + "output": "Chest Pain in Mid Sternum (Chest Pain in Sternum)" + }, + { + "input": "Definition: Skin and subcutaneous tissue ulcerations described as a circumscribed inflammatory lesion associated with underlying ischemic disease.", + "output": "Vasculitic ulcer (Skin and subcutaneous tissue ulcerations)" + }, + { + "input": "Definition: something described as an examination that is performed to determine the extent of the spread of cancer based on histopathologic examination of one or more pathology specimens. Pathologic staging uses evidence acquired during the process of clinical staging, supplemented by histopathologic examination of surgical specimens.", + "output": "Pathological staging (With staging)" + }, + { + "input": "Definition: regulation of inner ear receptor cell differentiation described as any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation.", + "output": "positive regulation of inner ear receptor cell differentiation (positive regulation of mechanoreceptor differentiation)" + }, + { + "input": "Definition: Natural Phenomenon or Process described as electromagnetic waves with frequencies between about 3 kilohertz (very low frequency - VLF) and 300,000 megahertz (extremely high frequency - EHF). They are used in television and radio broadcasting, land and satellite communications systems, radionavigation, radiolocation, and DIATHERMY. The highest frequency radio waves are MICROWAVES.", + "output": "Radiowaves (Radiation)" + }, + { + "input": "Definition: Neoplastic Process described as a neoplasm that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. These adenomas may become malignant (cancerous).", + "output": "Tubulovillous adenoma, NOS (Benign Neoplasm)" + }, + { + "input": "Definition: Mental Processes described as temporal duration of concentration or amount of material grasped during exposure to stimuli or information. Compare ATTENTION.", + "output": "Attention Span (Sustained attention)" + }, + { + "input": "Definition: Medical Device described as self-expanding vascular stents designed with the appropriate size and configuration for deployment in the iliac arteries. These stents typically consist of compressed metallic stents that open by themselves as soon as they are released. Iliac self-expanding stents are used mainly in stenotic lesions of the common or external iliac arteries, frequently after suboptimal angioplastic procedures.", + "output": "Iliac Artery Stents (Medical Device)" + }, + { + "input": "Definition: biology described as the branch of biology dealing with the study of animals.", + "output": "zoology (biology)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Head & Neck Symptom Index-22 Version 2 - I feel ill.", + "output": "NCCN-FACT FHNSI-22 Version 2 - I Feel Ill (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: something described as a question about whether it is not important that a doctor know a patient's culture and background in order to treat the person's illness.", + "output": "Not Important to Know Patient's Culture and Background to Treat their Illness (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Country described as a country in Southeastern Asia, northwest of Australia in the Lesser Sunda Islands at the eastern end of the Indonesian archipelago. East Timor includes the eastern half of the island of Timor, the Oecussi (Ambeno) region on the northwest portion of the island of Timor, and the islands of Pulau Atauro and Pulau Jaco.", + "output": "TIMOR-LESTE (Asia, Southeastern)" + }, + { + "input": "Definition: Streptococcus described as any bacterial organism that can be assigned to the species Streptococcus anginosus.", + "output": "Streptococcus anginosus (Andrewes and Horder 1906) Smith and Sherman 1938 (Approved Lists 1980) emend. Whiley and Beighton 1991 (Streptococcus)" + }, + { + "input": "Definition: Hyperkeratosis, CTCAE described as limiting self-care ADLs", + "output": "Grade 3 Hyperkeratosis (Hyperkeratosis, CTCAE)" + }, + { + "input": "Definition: something described as stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.", + "output": "Stage IVA Oropharynx Epidermoid Carcinoma (Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7)" + }, + { + "input": "Definition: something described as a measurement of the CCR5, chemokine (C-C motif) receptor type 5, in a biological specimen.", + "output": "C-C Chemokine Receptor Type 5 (Laboratory Procedure)" + }, + { + "input": "Definition: chemokine (C-C motif) ligand 2 signaling pathway described as a series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.", + "output": "CCL2/CCR4 signaling pathway (Cell Function)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as consent given by a subject, or in the case of an individual that can only give assent, by a parent or legal guardian, for the participation in a clinical study only after having achieved an understanding of both the relevant medical facts and the relevant risks involved.", + "output": "Consent, Informed (Legal Issues)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how hard it was for an individual to know where a person was if they couldn't see them speaking.", + "output": "When in Group of People and Could Not See Speaker, How Hard to Know Where That Person Was (Intellectual Product)" + }, + { + "input": "Definition: Randomization described as see randomization.", + "output": "unequal randomization (Randomization)" + }, + { + "input": "Definition: Cell Function described as the process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.", + "output": "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment (T cell lineage commitment)" + }, + { + "input": "Definition: something described as surgical clamps designed to provide a firm grip on the bronchi. These clamps are typically handheld, manual instruments including two parts pivoted at the center; they usually have atraumatic curved, right-angled, or obtuse-angled distal ends with longitudinal serrations. Bronchus clamps are mainly used during thoracic surgery.", + "output": "Bronchus clamp (Medical Device)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify genetic variants associated with Zellweger syndrome, a genetic disease in the Zellweger spectrum characterized by muscle weakness, feeding problems, hearing/vision loss, seizures, and other symptoms. Genetic variants at multiple loci have been associated with Zellweger syndrome. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple Zellweger syndrome-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Metabolic Disorder, Peroxisomal Disorder, Zellweger Spectrum, Zellweger Syndrome (IVD Panels, Human Genetics, Metabolic Disorder, Peroxisomal Disorder, Zellweger Spectrum)" + }, + { + "input": "Definition: Seminal vesicle fluid described as part of the ejaculated fluid. It contains secretions from the seminal vesicles, Cowper's gland, and prostate gland.", + "output": "semen (Body part)" + }, + { + "input": "Definition: Medical Device described as a pacemaker lead adaptor is a device used to adapt a pacemaker lead so that it can be connected to a pacemaker pulse generator produced by a different manufacturer.", + "output": "Pacemaker Lead Adapters, Implantable (Active Implantable Devices)" + }, + { + "input": "Definition: Peripheral Nervous System Neoplasms described as a rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.", + "output": "Intraneural Perineurioma (Tumor of spinal nerve and sheath)" + }, + { + "input": "Definition: something described as this gene may be involved in translation and protein acetylation.", + "output": "KINASE/PHOSPHATASE INHIBITOR 2 (Serine/Threonine Protein Kinase Gene)" + }, + { + "input": "Definition: Translation Process Protein described as aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (320 aa, ~35 kDa) is encoded by the human AIMP2 gene. This protein plays a role in the modulation of both translation and ubiquitination.", + "output": "Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as a measurement of iohexol in a biological specimen.", + "output": "Iohexol Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Gene or Genome described as human REV1 wild-type allele is located within 2q11.1-q11.2 and is approximately 90 kb in length. This allele, which encodes DNA repair protein REV1, is involved in the repair of replicating DNA.", + "output": "REV1, Polymerase (DNA Directed) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as uterine corpus cancer with tumor invasion of less than one-half of the myometrium.", + "output": "pT1b Carcinoma of the Uterus TNM Finding v6 (Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine.", + "output": "protein-(glutamine-N5) methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Most lethal attempt potential lethality.", + "output": "CSS10-Most Lethal Attempt Potential (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)" + }, + { + "input": "Definition: Organic Chemical described as a nutritional supplement containing the zinc salt form of gluconic acid for the purpose of providing zinc. As an essential trace element, zinc is of key importance in many biological processes, acts as an antioxidant and strengthens the immune system. Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84248\" active clinical trials using this agent.", + "output": "zinc gluconate (Zinc and zinc compound)" + }, + { + "input": "Definition: Mechanical cardiac valve prosthesis described as artificial cardiac valve prostheses designed with a circular disc as the active component. These prostheses consist of a circular ring covered by a plastic fabric (usually expanded polytetrafluoroethylene [ePTFE], a synthetic polymer made of carbon and fluorine) that holds a disc sometimes divided into two parts and is typically made of pyrolytic carbon. Heart contractions (i.e., pumping) open and close the disc acting as a valve. Tilting-disc artificial cardiac valves are frequently used to replace the mitral and/or aortic valve.", + "output": "Prostheses, Cardiac Valve, Artificial, Tilting-Disc (Medical Device)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the treatments used to prepare a patient for stem cell transplantation (a procedure in which a person receives blood stem cells, which make any type of blood cell). A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire body. It helps make room in the patient's bone marrow for new blood stem cells to grow, helps prevent the patient's body from rejecting the transplanted cells, and helps kill any cancer cells that are in the body.", + "output": "TRANSPL CONDITIONING (Chemotherapy)" + }, + { + "input": "Definition: Finding described as an abnormally increased number of myelocytes in the peripheral blood circulation. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and seconday granules, and a nucleus:cytoplasm ratio of 2:1.", + "output": "Increased circulating myelocyte count (Finding)" + }, + { + "input": "Definition: something described as a small, compact, muscular dog with square proportions and well-chiseled lines. It has a short coat that may be red, but may also be black and tan or chocolate. The dog has an unusual high stepping gait. The average height range is 10-12 inches and the average weight range is 8-10 pounds.", + "output": "Miniature Pinscher (Dog family)" + }, + { + "input": "Definition: Blaberoidea described as a family of insects in the order Dictyoptera (COCKROACHES), including genera Blattella, Parcoblatta, and Symploce.", + "output": "Ectobiidae (Dictyoptera )" + }, + { + "input": "Definition: Biomedical or Dental Material described as lyophilisate (freeze-dried powder) and solvent intended for the preparation of a nasal spray, suspension, for veterinary use, by dispersing the lyophilisate in the solvent.", + "output": "Nasal Spray, Lyophilisate and Solvent for Suspension Dosage Form (Combined Dosage Form)" + }, + { + "input": "Definition: something described as children's Depression Rating Scale, Revised - Subtotal 2 - sum of questions 7 to 14.", + "output": "CDRS1-Subtotal 2 (CDRS-R Clinical Classification Question)" + }, + { + "input": "Definition: Neoplastic Process described as when the disease process is confined to a mass lesion with no or minimal evidence of blood and less than 25% marrow involvement, the diagnosis is lymphoblastic lymphoma; with blood and greater than 25% marrow involvement, ALL is the appropriate term.", + "output": "Pediatric Acute Lymphoblastic Leukemia (Neoplastic Process)" + }, + { + "input": "Definition: amine-lyase activity described as catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin.", + "output": "deacetylisoipecoside synthase activity (amine-lyase activity)" + }, + { + "input": "Definition: QIDS-SR Questionnaire Question described as quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Please circle the one response to each item that best describes you for the past seven days: Sleeping too much.", + "output": "QIDSR1-Sleeping Too Much (QIDS-SR Questionnaire Question)" + }, + { + "input": "Definition: Finding described as an individual who stopped smoking more than 15 years prior.", + "output": "Current Reformed Smoker, More than 15 Years (Former smoker)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus.", + "output": "response to papulacandin B (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP.", + "output": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein (609 aa, ~66 kDa) encoded by the EWSR1/PATZ1 fusion gene long B isoform. This protein is comprised of the transactivation domain of the RNA-binding protein EWS fused to the C-terminus of POZ-, AT hook-, and zinc finger-containing protein 1 containing two C2H2 zinc-finger DNA binding domains.", + "output": "EWS/ZSG Fusion Protein Long B Isoform (EWSR1/PATZ1 Fusion Protein)" + }, + { + "input": "Definition: Z-phenylacetaldoxime metabolic process described as the chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds.", + "output": "Z-phenylacetaldoxime formation (Z-phenylacetaldoxime metabolic process)" + }, + { + "input": "Definition: Sign or Symptom described as a neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).", + "output": "Extrapyramidal tract signs (MOTOR FUNCTIONS AND DYSFUNCTIONS)" + }, + { + "input": "Definition: FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 - Additional Concerns: I have aches and pains that bother me.", + "output": "FACT-P Version 4 - Have Aches and Pains That Bother Me (FACT-P Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Sulfonylurea Antidiabetic Agent described as a second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, glisoxepide exerts greater binding affinity than the first-generation compounds. Glisoxepide shows peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity, has a short half-life and is excreted in both the bile and urine. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C72801\" active clinical trials using this agent.", + "output": "glisoxepid (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a rule or order issued by an authority stating what may or may not be done or how something must be done. In clinical trials, includes rules issued by, but not limited to, FDA, EMA, ICH and other regulatory agencies.", + "output": "regulation (Document type)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a rare genetic primary bone dysplasia with characteristics of disproportionate short stature with short, stiff neck and trunk and relatively long limbs, fingers and toes (which may present flexion contractures), severe vertebral body ossification delay, markedly enlarged round epiphyses of the long bones, absent ossification of pubic bones and multiple pseudoepiphyses of the short tubular bones in hands and feet. Neurological manifestations resulting from cervical spine instability may be observed. There is evidence the disease is caused by homozygous inactivating mutations in the NKX3-2 gene on chromosome 4p15.", + "output": "SMMD (Disease or Syndrome)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as any component of the filamentous outgrowth of the epidermis.", + "output": "Hair Part (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Malignant neoplasm of large intestine described as cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus).", + "output": "Carcinoma;intestine;large (Gastrointestinal carcinoma)" + }, + { + "input": "Definition: something described as reduced convexity of the occiput (posterior part of skull).", + "output": "Flat posterior cranium (Finding)" + }, + { + "input": "Definition: something described as a regimen consisting of docetaxel and goserelin that can be used for the treatment of prostate cancer.", + "output": "Docetaxel/Goserelin Regimen (Regimen Used to Treat Prostate Carcinoma)" + }, + { + "input": "Definition: Protease Inhibitors described as a family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.", + "output": "Tissue Inhibitor of Metalloproteinases (Protease Inhibitors)" + }, + { + "input": "Definition: Europe described as an overseas territory of the United Kingdom in southwestern Europe, bordering the Strait of Gibraltar.", + "output": "Gibraltar (Country)" + }, + { + "input": "Definition: Solution Dosage Form described as a solution composed of a clear, sweetened hydroalcoholic liquid in which active and/or inert ingredient(s) are dissolved.", + "output": "Elixir (Biomedical or Dental Material)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 9q", + "output": "9q21-q22 (Cell Component)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine.", + "output": "1,2-dihydrovomilenine:NADP+ oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Bridged Bicyclo Compounds, Heterocyclic described as a drug that is used to treat infection. It belongs to the family of drugs called antibiotics.", + "output": "PENICILLIN (Monobactams)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a humanized monoclonal antibody directed against the human immunosuppressive molecule CD200 (OX-2) with potential immunomodulating and antineoplastic activities. Samalizumab binds to CD200, blocking the binding of CD200 to its receptor, CD200R, present on cells of the macrophage lineage. Inhibition of CD200 may augment the cytotoxic T-lymphocyte (CTL) mediated immune response against CD200-expressing tumor cells. CD200 is a type 1a transmembrane protein, related to the B7 family of co-stimulatory receptors, and is upregulated on the surface of multiple hematologic malignant cells; this transmembrane protein appears to be involved in the downregulation of a Th1 (helper T cell) immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77891\" active clinical trials using this agent.", + "output": "Samalizumab (Monoclonal Antibodies)" + }, + { + "input": "Definition: something described as debulking surgery that is performed after neoadjuvant chemotherapy or induction chemotherapy and is followed by additional adjuvant chemotherapy of the same type.", + "output": "IDS (Tumor Debulking)" + }, + { + "input": "Definition: Chemical synapse described as synapse between a neuron and a muscle.", + "output": "Myoneural junction (Nerve part)" + }, + { + "input": "Definition: Organic Chemical described as PHENOTHIAZINES with an amino group at the 3-position that are green crystals or powder. They are used as biological stains.", + "output": "Azure Stains (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: medical specialty by disease group described as the study or science of neoplastic growth; for thorough searching see RTs.", + "output": "Cancer, Oncology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: something described as an increase in the level of ribose in the urine.", + "output": "Increased level of ribose in urine (Finding)" + }, + { + "input": "Definition: smooth muscle contraction described as a process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.", + "output": "colon smooth muscle contraction (smooth muscle contraction)" + }, + { + "input": "Definition: Pathology described as the branch of pathology concerned with diseases and disorders of the blood and blood-forming organs.", + "output": "Hematopathology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as an assessment of the Adaptive Behavior Assessment System, where leisure skills such as planning recreational activities, playing with others, and following rules of games are evaluated.", + "output": "Leisure Skills (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as an isoform of fibroblast growth factor receptor 2 where alternative splicing leads to the expression of the IIIb exon encoding the second half of the third immunoglobulin-like domain, which is located in the extracellular domain of these receptors. This variant is expressed in epithelial lineage cells and has differential ligand binding activity when compared to the IIIa and IIIc forms.", + "output": "FGFR2IIIb (Receptor)" + }, + { + "input": "Definition: something described as the type of response noted after treatment was given for Kawasaki disease.", + "output": "Intervention for Kawasaki Disease, Type of Response (Classification)" + }, + { + "input": "Definition: Implantation - action described as transference of a tissue or organ within an individual, between individuals of the same species, or between individuals of different species.", + "output": "Transplant Procedure (Therapeutic procedure)" + }, + { + "input": "Definition: Professional or Occupational Group described as a pediatrician or neurologist who specializes in the diagnosis and management of chronic conditions that affect the developing and mature nervous system such as cerebral palsy, mental retardation and chronic behavioral syndromes, or neurologic conditions.", + "output": "Allopathic & Osteopathic Physicians; Psychiatry & Neurology, Neurodevelopmental Disabilities (Professional or Occupational Group)" + }, + { + "input": "Definition: COSTART described as the abnormal mechanisms and forms involved in the dysfunctions of tissues and organs.", + "output": "pathological processes (Concept model attribute)" + }, + { + "input": "Definition: positive regulation of neutrophil mediated killing of bacterium described as any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil.", + "output": "upregulation of neutrophil mediated killing of gram-positive bacterium (regulation of neutrophil mediated killing of gram-positive bacterium)" + }, + { + "input": "Definition: something described as the determination of the amount of ammonia present in a sample.", + "output": "Ammonia Measurement (Intermediary products of metabolism measurement)" + }, + { + "input": "Definition: something described as separation of powders or granules into fractions differentiated by a characteristic size range (e.g., mesh size) by movement of the particles through a series of fixed screens, or the removal of oversized agglomerates without milling, generally with the aid of mechanical vibration or shaking.", + "output": "Particle Sizing, Screening (Laboratory Procedure)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Home Assay, Urine described as reagents available as home-test kits that permit the determination of nitrates in a sample of urine. Nitrate determination kits for home use permit patients to check the levels of nitrates in their urine. They are used during some medical treatments.", + "output": "IVD Test Reagent/Kits, Home Assay, Urine, Nitrate (Medical Device)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 1406 of the coding sequence of the BRAF gene where guanine has been mutated to cytosine.", + "output": "v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1406G>C (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: rRNA transcription described as the synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template.", + "output": "rRNA transcription from mitochondrial promoter (rRNA transcription)" + }, + { + "input": "Definition: Qualitative Concept described as indicates a biomedical image that is of acceptable quality, with some technical defect but still adequate for diagnostic purposes.", + "output": "Limited Quality (Image Quality)" + }, + { + "input": "Definition: Esophageal carcinoma described as a carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.", + "output": "Esophageal Squamous Cell Cancer (Disease of mucous membrane)" + }, + { + "input": "Definition: something described as solitary lesion measuring less than 5 cm.", + "output": "Primary Cutaneous Lymphoma Other Than Mycosis Fungoides and S\u00e9zary Syndrome T1a TNM Finding v8 (Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma T1 TNM Finding v8)" + }, + { + "input": "Definition: Duplication of phalanx of 3rd finger described as a complete duplication affecting one or more of the phalanges of the 3rd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.", + "output": "Complete duplication of middle finger bones (Anatomical Abnormality)" + }, + { + "input": "Definition: Finding described as a elevation in the rate of apoptosis in lymphocytes. []", + "output": "Increased lymphocyte apoptosis (Finding)" + }, + { + "input": "Definition: Adult Hodgkin Lymphoma described as an anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.", + "output": "Adult Hodgkin Lymphoma by Ann Arbor Stage (Hodgkin Lymphoma by Ann Arbor Stage)" + }, + { + "input": "Definition: Finding described as severe symptoms; limiting self care ADL; oxygen indicated", + "output": "Grade 3 Pneumonitis, CTCAE (Finding)" + }, + { + "input": "Definition: tRNA aminoacylation for mitochondrial protein translation described as the process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.", + "output": "mitochondrial alanyl-tRNA aminoacylation (alanyl-tRNA aminoacylation)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a peripheral neural block of the medial and lateral pectoral nerves.", + "output": "PECS 1 (Nerve Block)" + }, + { + "input": "Definition: something described as a symptom complex characterized by nervousness, chest pain, back pain, palpations, pruritus, and other usually mild symptoms occurring minutes following the initiation of dialysis with a new dialyzer.", + "output": "First use syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: DNA dependent adenosinetriphosphatase activity described as catalysis of the reaction: ATP + H2O = ADP + phosphate, coupled to the topological linking or unlinking of a cohesin ring complex around homologous chromosomes.", + "output": "cohesin ATPase activity (Molecular Function)" + }, + { + "input": "Definition: Awl described as awls designed for piercing small holes in cartilage. They are typically handheld, manual instruments with a slender, straight or curved, and frequently grooved working blade with a very sharp point and a handle that is an integral part or attached to the working blade. Cartilage awls are usually smaller and more slender than bone awls. These awls are used in plastic surgery (e.g., facial reconstruction) and oral surgery procedures; dedicated cartilage awls are also available for a variety of procedures (e.g., to fix nasal deformities, for lip augmentation).", + "output": "Awls, Cartilage (Awl)" + }, + { + "input": "Definition: Laboratory Procedure described as the measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by scintillation counting.", + "output": "radioassay (Techniques)" + }, + { + "input": "Definition: something described as an astrocytoma that arises from the cerebral hemispheres.", + "output": "Astrocytoma of the Cerebrum (Astrocytoma of brain)" + }, + { + "input": "Definition: Finding described as a response indicating unknown Tamoxifen use.", + "output": "Unknown Tamoxifen Use (Finding)" + }, + { + "input": "Definition: Urea Cycle Disorders, Inborn described as a genetic inherited disorder caused by mutations in the ASL gene. It is characterized by accumulation of ammonia in the blood. It presents with lethargy in the first few days of life, accompanied by developmental delay and mental retardation.", + "output": "ASL deficiency (Enzyme Deficiency)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) Activities: are you able to get in and out of a car?", + "output": "HAQ0132 (Intellectual Product)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with the beta subunit of the catenin complex.", + "output": "beta-catenin binding (Molecular Function)" + }, + { + "input": "Definition: negative regulation of branch elongation involved in ureteric bud branching described as a series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis.", + "output": "negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway (negative regulation of branch elongation involved in ureteric bud branching)" + }, + { + "input": "Definition: Immune System Diseases described as a disorder caused by the presence of autoantibodies directed against phospholipids, causing a hypercoaguable state, which may result in blood clots, stroke, heart attack, and in women, significant pregnancy-related complications, including miscarriage and still birth. The syndrome is often associated with other autoimmune disorders, most commonly lupus erythematosus, and infections, including syphilis and Lyme disease.", + "output": "Antiphospholipid syndrome (Autoimmune Diseases)" + }, + { + "input": "Definition: L-alanine transport described as the directed movement of L-alanine across a membrane.", + "output": "L-alanine transmembrane transport (cation transmembrane transport)" + }, + { + "input": "Definition: Quantitative Concept described as the current value minus the lowest value previously recorded.", + "output": "Absolute Change From Nadir (Changing)" + }, + { + "input": "Definition: Organism Function described as production of offspring by selective mating in animals.", + "output": "animal breeding (Organism Function)" + }, + { + "input": "Definition: Biologically Active Substance described as the beta subunit of mitochondrial trifunctional protein that contains acetyl-CoA C-acyltransferase activity. There are four of these beta subunits in each trifunctional protein complex.", + "output": "Mitochondrial Trifunctional Protein, beta Subunit (Mitochondrial Trifunctional Protein)" + }, + { + "input": "Definition: something described as catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate.", + "output": "hexaprenyl diphosphate synthase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)" + }, + { + "input": "Definition: branchiomotor neuron axon guidance in neural tube described as the process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.", + "output": "chemoattraction of branchiomotor neuron axon in neural tube (chemoattraction of branchiomotor axon)" + }, + { + "input": "Definition: something described as any fungal organism that can be assigned to the species Aspergillus niger.", + "output": "Aspergillus lacticoffeatus Frisvad & Samson, 2004 (Aspergillus)" + }, + { + "input": "Definition: Space of compartment of neck described as space of compartment of head between the esophagus and the prevertebral fascia.", + "output": "Retrovisceral space of neck (Body Space or Junction)" + }, + { + "input": "Definition: Finding described as problem associated with the violent bursting due to the sudden expansion of air, gas or fluid.", + "output": "Medical Device Explosion Issue (Finding)" + }, + { + "input": "Definition: phenol beta-glucosyltransferase activity described as catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP.", + "output": "UDPglucose:phosphopolyprenol D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)" + }, + { + "input": "Definition: Arteriography described as a procedure in which the catheter is passed into the aortic root or other great vessels for the purpose of angiography of the native coronary arteries or bypass grafts supplying native coronary arteries.", + "output": "Angiography of coronary arteries (Exploration of coronary artery)" + }, + { + "input": "Definition: something described as a double-stranded DNA virus that infects bacteria such as E. coli.", + "output": "Enterobacteria Phage T4 (T-Phages)" + }, + { + "input": "Definition: Finding described as a tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.", + "output": "Balance impairment (Finding)" + }, + { + "input": "Definition: Personnel Management described as prejudiced and differential treatment of employees or job applicants based on factors other than performance or qualifications.", + "output": "Employment Discrimination (Social Discrimination)" + }, + { + "input": "Definition: Quantitative Concept described as a population for a geographic area, such as the U.S. or the world, represented as a table giving the proportions of the population falling into different age groups.", + "output": "Standard Population (Population Group)" + }, + { + "input": "Definition: something described as a rare developmental defect during embryogenesis with characteristics of mild to moderate intellectual disability and psychomotor delay, Robin sequence (including severe micrognathia and soft palate cleft) and distinct dysmorphic facial features (e.g. synophrys, short palpebral fissures, hypertelorism, small, low-set and posteriorly angulated ears, bulbous nose, long/flat philtrum and bow-shaped upper lip). Skeletal anomalies such as brachydactyly, clinodactyly, small hands and feet, and oral manifestations (e.g. bifid, short tongue, oligodontia) are also associated. Additional features reported include microcephaly, capillary haemangiomas on face and scalp, ventricular septal defect, corneal clouding, nystagmus and profound sensorineural deafness.", + "output": "Intellectual disability, brachydactyly, Pierre Robin syndrome (Multiple malformation syndrome with facial-limb defects as major feature)" + }, + { + "input": "Definition: Infections and Infestations, CTCAE described as a disorder characterized by an infectious process involving the cornea.", + "output": "Corneal Infection (Finding)" + }, + { + "input": "Definition: something described as development of diabetes after transplant, usually associated with calcineurin inhibitor use.", + "output": "New Onset Diabetes After Transplant (Disease or Syndrome)" + }, + { + "input": "Definition: Squamous cell breast carcinoma described as a squamous cell carcinoma that arises from the breast parenchyma and has metastasized to other anatomic sites.", + "output": "Metastatic Squamous Cell Carcinoma of the Breast (Neoplastic Process)" + }, + { + "input": "Definition: something described as CASP8 and FADD-like apoptosis regulator isoform 2 (221 aa, ~25 kDa) is encoded by the human CFLAR gene. This protein is involved in the regulation of caspase-dependent apoptosis.", + "output": "apoptosis-inducer Casper, human (Enzyme)" + }, + { + "input": "Definition: Finding described as the longest measured width of the umbilical cord.", + "output": "Umbilical Cord Diameter (Finding)" + }, + { + "input": "Definition: congenital malformation syndromes affecting multiple systems described as a hereditary disorder associated with impaired DNA double-strand break repair mechanisms with characteristics of microcephaly, unusual facial features, growth and developmental delay, skin anomalies, and pancytopenia, which is associated with combined immunodeficiency. Caused by mutations in the LIG4 gene (13q22-q34). The resulting defect of DNA ligase IV, a component of the classical non-homologous end-joining (NHEJ) pathway, affects the major mechanism of DNA double-strand break repair. Transmission is autosomal recessive.", + "output": "LIG4 syndrome (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Idea or Concept described as indicates the person, group, or institution who performed the collection act.", + "output": "Obtained By (General Qualifier)" + }, + { + "input": "Definition: regulation of cellular carbohydrate catabolic process described as any process that modulates the frequency, rate or extent of cellobiose catabolic process.", + "output": "regulation of cellobiose catabolic process (regulation of cellular carbohydrate catabolic process)" + }, + { + "input": "Definition: Manufactured Object described as a structural device part that supports or aligns other parts.", + "output": "Post Device (Manufactured Object)" + }, + { + "input": "Definition: Intellectual Product described as neuropsychiatric Inventory - Does the patient describe any other unusual sensory experiences?", + "output": "NPI1-Other Unusual Sensory Experience (Intellectual Product)" + }, + { + "input": "Definition: rndx respiratory described as inability to tolerate decreased levels of ventilator support", + "output": "Ventilatory Weaning Impairment (rndx respiratory)" + }, + { + "input": "Definition: something described as an osteoma that develops on the surface of the bone.", + "output": "Ivory Exostosis (Osteoma)" + }, + { + "input": "Definition: Protein Binding described as interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.", + "output": "scaffold protein binding (Molecular Function)" + }, + { + "input": "Definition: Allergies to foods, food additives, drugs and other chemicals described as a potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs.", + "output": "Drug Reaction with Eosinophilia and Systemic Symptoms (Eosinophilia)" + }, + { + "input": "Definition: IPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Self-Administered Format - During the last 7 days, on how many days did you walk for at least 10 minutes at a time?: days per week.", + "output": "IPAQ Short Last 7 Days Self-administered Format Version - Days Walk at Least 10 Minutes (Intellectual Product)" + }, + { + "input": "Definition: Health Care Related Organization described as the National Institute of General Medical Sciences (NIGMS) primarily supports basic biomedical research that is not targeted to specific diseases or disorders.", + "output": "NIGMS (Health Care Related Organization)" + }, + { + "input": "Definition: Pain and Sensation Related to the Thoracic Organs described as the sensation of chest pain described as a mild or blunted discomfort.", + "output": "CHEST PRESSURE SENSATION (CHEST PAIN AND SENSATIONS RELATED TO THORACIC ORGANS)" + }, + { + "input": "Definition: something described as major organ of equilibrium which acts as a sensory receptor that detects the position and changes in the position of the head in space.", + "output": "Vestibules, Labyrinth (Membranous labyrinth structure)" + }, + { + "input": "Definition: Cancer TNM Finding by Site described as a finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system.", + "output": "Breast Cancer TNM Finding v7 (Cancer TNM Finding by Site)" + }, + { + "input": "Definition: Intranuclear Space described as the region within a cell nucleus where ribosomal DNA is clustered, ribosomal RNA is synthesized and ribosomes are assembled.", + "output": "Cell Nucleoli (Cell Nucleus Structures)" + }, + { + "input": "Definition: Medicinal product categorized by structure described as an orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81934\" active clinical trials using this agent.", + "output": "Ibrutinib (Pharmacologic Substance)" + }, + { + "input": "Definition: Symptom Specific Assessment Tool described as a global index that evaluates disease activity and includes twenty-four items collecting specific manifestations in nine organ systems: neurological, musculoskeletal, renal, mucocutaneous, general, heart, respiratory, vascular, and hematological. These items are scored based on whether these manifestations are present or absent in a specified time period. Several versions of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) are available.", + "output": "disease activity index systemic lupus erythematosus (Intellectual Product)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Taxane Version 4 test code.", + "output": "Functional Assessment of Cancer Therapy-Taxane Version 4 Questionnaire Test Code (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as a NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.", + "output": "Caspase Recruitment Domain Protein 15 (CARD Signaling Adaptor Proteins)" + }, + { + "input": "Definition: Cardiovascular Diseases described as origin of aorta from right ventricle and pulmonary trunk from left ventricle. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)", + "output": "TRANSPOSITION GREAT VESSEL (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: positive regulation of glycogen metabolic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "output": "positive regulation of glycogenolysis (regulation of glycogen catabolic process)" + }, + { + "input": "Definition: Pharmacologic Substance described as basil.", + "output": "ocimum basilicum/basil (Organic Chemical)" + }, + { + "input": "Definition: something described as reagents intended to establish points of reference (i.e., calibrate) in immunoassay tests performed to determine one or more of a group of lipid-protein complexes in which lipids are transported in the blood. These reagents may be either specific for calibration of a lipoprotein or, more frequently, appropriate to calibrate a whole set of similar lipoproteins.", + "output": "IVD Test Reagent/Kits, Immunoassay, Calibration, Lipoprotein (IVD Test Reagent/Kits, Immunoassay, Calibration)" + }, + { + "input": "Definition: something described as mini-Mental State Examination (MMSE) What were those three words I asked you to remember: Word 1?", + "output": "MMS1-Recall Word 1 (MMSE Functional Test Question)" + }, + { + "input": "Definition: something described as the essential oil of Cymbopogon schoenanthus. Cymbopogon schoenanthus oil is used for its aromatic properties.", + "output": "CYMBOPOGON SCHOENANTHUS OIL (Natural Products)" + }, + { + "input": "Definition: something described as the process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter.", + "output": "ureter epithelial cell differentiation (Cell Function)" + }, + { + "input": "Definition: Global mental functions described as general mental functions of constitutional disposition of the individual to react in a particular way to situations, including the set of mental characteristics that makes the individual distinct from others.", + "output": "Temperament and personality functions (Global mental functions)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (1634 aa, ~185 kDa) is encoded by the human PIK3C2B gene. This protein is involved in both second messenger signaling and the phosphorylation of phosphoinositol.", + "output": "C2-PI3K (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as auditory Verbal Learning Test Version A - List A, Recall 4, Word 6.", + "output": "ADNI AVLT - List A Recall 4 Word 6 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: something described as a vaccine consisting of a recombinant, attenuated, replication-incompetent form of the Semliki Forest Virus (SFV) vector encoding the viral oncoproteins E6 and E7 derived from the human papillomavirus (HPV), with potential immunomodulating and antineoplastic activities. Upon intramuscular administration, HPV E6/E7-encoding SFV vaccine Vvax001 induces expression of the E6/E7 proteins and stimulates both the innate and the adaptive immune system, resulting in a potent cytotoxic T-lymphocyte (CTL) response against and lysis of tumor cells expressing HPV E6 and E7. Oncoproteins E6 and E7 play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.", + "output": "HVP E6/E7-encoding Semliki Forest virus vaccine Vvax001 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation.", + "output": "trans-translation-dependent protein tagging (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein encoded by the KISS1 gene.", + "output": "KISS1 Gene Product (Biologically Active Substance)" + }, + { + "input": "Definition: ROBO1 gene described as human ROBO1 wild-type allele is located in the vicinity of 3p12 and is approximately 1170 kb in length. This allele, which encodes roundabout homolog 1 protein, plays a role in both axon guidance and neuroblast migration.", + "output": "Roundabout, Drosophila, Homolog of, 1 Gene (Gene or Genome)" + }, + { + "input": "Definition: Congenital anomaly of the kidney described as a genetic disorder with autosomal recessive inheritance, characterized by multiple CYSTS in both KIDNEYS and associated LIVER lesions. Serious manifestations are usually present at BIRTH with high PERINATAL MORTALITY.", + "output": "Polycystic Kidney and Hepatic Disease 1 (Polycystic Kidney Diseases)" + }, + { + "input": "Definition: something described as an aliphatic analogue of busulfan with potential antineoplastic activity. As an alkylating agent, dimethylbusulfan induces neutropenia and has been shown to exhibit antitumor effects in some animal models. Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1073\" active clinical trials using this agent.", + "output": "DMM (Pharmacologic Substance)" + }, + { + "input": "Definition: gastrointestinal described as a pouch or sac opening from the COLON.", + "output": "Diverticula, Colonic (Diverticulum)" + }, + { + "input": "Definition: Quantitative Concept described as a product containing six individual units.", + "output": "Six Pack (Package Dosing Unit)" + }, + { + "input": "Definition: Finding described as the assessment of the severity of doming of a cardiac valve cusp.", + "output": "Cusp Doming Severity (Cardiovascular finding)" + }, + { + "input": "Definition: something described as a chromosome band present on 12q", + "output": "12q22-q23 (Chromosome band)" + }, + { + "input": "Definition: Pesticides described as the organophosphorus agent isazophos.", + "output": "ISAZOPHOS (Organic Chemical)" + }, + { + "input": "Definition: something described as a device that is designed as a removable and replaceable part of another device.", + "output": "Cell (Medical Device)" + }, + { + "input": "Definition: Quantitative Concept described as the numeric value to indicate an increase in voxel signal over time for an MRI, expressed as signal intensity units per second.", + "output": "enhancementRateValue (Quantitative Concept)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport.", + "output": "regulation of mitochondrial ATP synthesis coupled proton transport (regulation of proton transport)" + }, + { + "input": "Definition: Rare Non-Neoplastic Disorder described as a rare autosomal recessive inherited syndrome characterized by situs inversus, bronchiectasis, and chronic sinusitis. There is a defect in the function of the cilia that line the respiratory tract.", + "output": "KARTAGENER SYNDROME (Disease or Syndrome)" + }, + { + "input": "Definition: Biomedical Cement described as adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.", + "output": "BONE CEMENT (Biomedical or Dental Material)" + }, + { + "input": "Definition: dendritic spine organization described as the organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.", + "output": "dendritic spine maintenance (Cell Function)" + }, + { + "input": "Definition: something described as death in utero; failure of the product of conception to show evidence of respiration, heart beat, or definite movement of a voluntary muscle after expulsion from the uterus, with no possibility of resuscitation.", + "output": "Foetal death (BODY AS A WHOLE - GENERAL DISORDERS)" + }, + { + "input": "Definition: something described as a blood concentration of prostate specific antigen greater than or equal to 5 ng/mL.", + "output": "PSA Level Greater than or Equal to 5 (PSA Level Finding)" + }, + { + "input": "Definition: Abnormality of the thyroid gland described as an abnormal functionality of the thyroid gland.", + "output": "Thyroid function abnormal (Finding)" + }, + { + "input": "Definition: something described as a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.", + "output": "Product containing aprepitant (Emetogenic Therapy Adjuncts)" + }, + { + "input": "Definition: Organic Chemical described as ACETIC ACID or acetic acid esters substituted with one or more CHLORINE atoms.", + "output": "Chloroacetates (Hydrocarbons, Chlorinated)" + }, + { + "input": "Definition: something described as a question about the extent to which an individual has or had pain in their jaw.", + "output": "Extent Have Pain in Jaw (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in binding to tyrosine-protein kinase HCK.", + "output": "C2ORF44 (Gene or Genome)" + }, + { + "input": "Definition: Pilar disorders NEC described as an inherited defect of intestinal copper absorption in males It is characterized by sparse, stubby, twisted, and friable, and colorless hair and irregular eyebrows associated with retarded mental and physical development, focal cerebral and cerebellar degeneration, cherubic expressionless facies, and micrognathia. The course is usually progressively fatal.", + "output": "Diseases, Steely Hair (Brain Diseases, Metabolic, Inborn)" + }, + { + "input": "Definition: Neoplastic Process described as a plasma cell neoplasm arising at an extraosseous site. There is no involvement of the bone marrow. It most frequently involves the oropharynx, nasopharynx, sinuses, and larynx. Other sites of involvement include the gastrointestinal tract, central nervous system, breast, skin, lymph nodes, and bladder. A minority of patients have a monoclonal gammopathy. Treatment includes radiation therapy. Progression to plasma cell myeloma occurs in a minority of patients. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4002\" active clinical trials using this agent.", + "output": "Malignant plasma cell neoplasm, extramedullary plasmacytoma (stage, plasma cell neoplasm)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.", + "output": "Uterine Carcinosarcoma, Homologous Type (Neoplastic Process)" + }, + { + "input": "Definition: Disorder of soft tissue of upper limb described as an abnormal accumulation of fluid beneath the skin of the arms.", + "output": "Fluid accumulation in upper limbs (Peripheral edema)" + }, + { + "input": "Definition: N-terminal protein palmitoylation described as the covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine.", + "output": "N-terminal peptidyl-glycine N-palmitoylation (N-terminal protein palmitoylation)" + }, + { + "input": "Definition: Unit of Content described as a unit of amount of substance content measured as the number of moles of a solute substance (component) per mass of the solvent.", + "output": "Molality Unit (Quantitative Concept)" + }, + { + "input": "Definition: Chewable Tablet described as solid single-dose preparation consisting of an uncoated tablet intended either to be chewed before being swallowed, or to be dispersed in the specified liquid before being swallowed.", + "output": "Chewable-Dispersible Tablet Dosage Form (Chewable Tablet)" + }, + { + "input": "Definition: G Protein-Coupled Receptor Genes described as this gene may be involved in G protein-coupled receptor signaling.", + "output": "GPR160 gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a tall and elegant sighthound with a short, fine coat that can be red, clear sand to fawn, brindled, parti-colored, blue black, or brown. This dog excels as a companion, guardian, and lure courser. The average height range is 23.5-29 inches and the average weight range is 33-55 pounds.", + "output": "Azawakh (Mammal)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as n-cym protein (109 aa, ~12 kDa) is encoded by the human MYCNOS gene. This protein may play a role in embryonic development.", + "output": "MYCNOS (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation.", + "output": "down-regulation of metabolic activity during hibernation (Organism Function)" + }, + { + "input": "Definition: Colorectal and anal neoplasms malignancy unspecified described as tumors or cancer of the RECTUM.", + "output": "Tumor of rectum (oncologic disorders)" + }, + { + "input": "Definition: Finding described as retinoblastoma with no lymph node involvement.", + "output": "Retinoblastoma pN0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Organic Chemical described as a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1464\" active clinical trials using this agent.", + "output": "1,2,4-Benzotriazin-3-amine, 1,4-dioxide (Antineoplastic Agents)" + }, + { + "input": "Definition: protein-containing complex described as the proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.", + "output": "proteasome core complex, alpha-subunit complex location (protein-containing complex)" + }, + { + "input": "Definition: Secondary malignant neoplasm of male genital organ described as a malignant neoplasm that has metastasized to the epididymis from another anatomic site.", + "output": "Metastatic Malignant Neoplasm to the Epididymis (Secondary Neoplasm)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of ratio of the spherical area to the square of the radius. The spherical area is a rectilinear projection of the object of any shape onto a plane normal to the unit vector, and the solid angle is the surface area of that projection.", + "output": "Solid Angle Unit (Quantitative Concept)" + }, + { + "input": "Definition: something described as experimental condition created by disrupting cells with homogenization, sonication, detergents, or other treatment, leaving intracellular components exposed to controlled manipulation of the medium.", + "output": "Cellfree System (In Vitro Assay)" + }, + { + "input": "Definition: something described as the science concerned with the normal processes of hearing", + "output": "Auditory Physiology (Sensory Physiology)" + }, + { + "input": "Definition: Physical & Psychosomatic Disorders described as pain which has persisted over a long period of time; also use NTs for specific types of pain if appropriate.", + "output": "Chronic Pains (Symptomatology)" + }, + { + "input": "Definition: Bacterium described as a species of Gram positive, cocci shaped bacteria assigned to the phylum Firmicutes. This species is catalase negative, nonsporulating, and ferments lactose, maltose, starch, glucose and trehalose. H. kunzii is a nonvirulent member of the skin flora, but may become an opportunistic pathogen in immunocompromised patients and has been isolated from wounds and breast masses.", + "output": "Helcococcus kunzii Collins et al. 1993 (Helcococcus)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the retinoschisin 1 (RS1) gene, located at chromosome Xp22.2-p22.1, which encodes for a secreted protein crucial to the cellular organization of the retina. This genetic mutation has been identified in patients with X-linked inherited juvenile retinoschisis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RS1 (Medical Device)" + }, + { + "input": "Definition: Manufactured Object described as combinations of devices (units), ancillary devices, and accessories designed to provide low temperatures above the freezing point of water (i.e., 0 degrees Celsius [32 degrees Fahrenheit]), typically from 2 to 10 degrees Celsius (35 to 50 degrees Fahrenheit), to a walk-in enclosure (i.e., a chamber) especially designed for this purpose or conditioned from an existing healthcare facility room. This equipment typically consists of compressors, fans, evaporators, ducted-air distribution systems, thermometers, temperature controls, and warming systems to balance the temperature; it may also include a recording temperature chart and alarms for dependable long-term storage. The characteristics of the equipment depend on the size, location, and intended use of the chamber (e.g., food storage, laboratory, morgue).", + "output": "Refrigeration System Equipment (Electromechanical Devices)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.", + "output": "glycolytic process from sucrose through glucose and fructose (glycolytic process from sucrose)" + }, + { + "input": "Definition: Finding described as a disorder characterized by inability to control the flow of urine from the bladder.", + "output": "Urinary Incontinence, CTCAE 5 (Renal and Urinary Disorders, CTCAE)" + }, + { + "input": "Definition: Injury or Poisoning described as injury to the eye secondary to a chemical substance.", + "output": "burn chemical eye (Chemical injury)" + }, + { + "input": "Definition: Endocrine system described as a course of food intake prescribed for patients, that limits the amount of foods with a high GLYCEMIC INDEX.", + "output": "Diabetic Diets (Disease-related diet)" + }, + { + "input": "Definition: something described as zinc Finger Protein ZFPM1 (1004 aa, ~105 kDa) is encoded by the human ZFPM1 gene. This protein is involved in the regulation of transcription.", + "output": "Friend of GATA-1 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as an indication that something has lasted, or occurred during, 20 years or more.", + "output": "Greater than or Equal to 20 Years (Period)" + }, + { + "input": "Definition: something described as devices designed to collect stones (i.e., calculi) from the urine during normal micturation. These strainers usually consist of a sieve with handles (e.g., built-in ridges) for easy manipulation; they are frequently attached to specimen containers. Each sample is sent to the clinical laboratory after stone collection for a pre-determined time period (usually 24 hours). Urine strainers are used every time the patient urinates during several days or weeks, typically until there are no stone fragments in the urine for several days. Determination of the chemical composition (e.g., calcium, cystine, uric acid) of calculi facilitates diagnosis and/or therapeutic treatment of the patient.", + "output": "Kidney Stone Strainers (Device Labeled for Single Use)" + }, + { + "input": "Definition: Metals, Heavy described as element of the rare earth family of metals, atomic symbol Y, atomic number 39; used a phosphor in television receivers and as a component of the yttrium aluminum garnet (YAG) lasers.", + "output": "Yttrium, NOS (Yttrium and yttrium compound)" + }, + { + "input": "Definition: IVIS Questionnaire Question described as impact of Visual Impairment Scale - During the past 4 weeks, how difficult did you find it to watch television or identify faces from a distance?", + "output": "IVIS - Watch TV or Identify Faces From Distance (Intellectual Product)" + }, + { + "input": "Definition: something described as high urine potassium in the presence of hypokalemia.", + "output": "Renal K wasting (Finding)" + }, + { + "input": "Definition: Classification described as characteristics include length >2 cm, extensive tortuosity of proximal segment, extremely angulated segments, and total occlusion >3 months old", + "output": "Type C (Classification)" + }, + { + "input": "Definition: Metallopeptidase Gene described as this gene is involved in the catabolism of insulin and other bioactive peptides.", + "output": "INSULIN-DEGRADING ENZYME (Gene or Genome)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as assessing possible postmaturity of a client/patient's pregnancy to identify maternal and/or fetal risk factor(s) and the level of care required. Service is billed in 15-minute increments.", + "output": "Surveillance: late pregnancy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: File described as a formalized system of organizing and storing digital content such as documents, images and other digital content items in an electronic record management system for clinical trials. The term TMF encompasses documents related to strategies, methods, tools and personnel engaged throughout the lifecycle of the clinical trial regulated content. Items in a TMF may be required for compliance with government regulatory agencies.", + "output": "eTMF (File)" + }, + { + "input": "Definition: Renal Pelvis and Ureter Cancer by AJCC v8 Stage described as a term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes.", + "output": "Ureter Cancer by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as auditory Verbal Learning Test Version A - List A, Recall 2, Word 12.", + "output": "AVL01-List A Recall 2 Word 12 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a document which has been approved by the Institutional Review Board (IRB) or Independent Ethics Committee (IEC) to capture Subject data away from the Site.", + "output": "IRB-IEC Approved Subject Diary (Document type)" + }, + { + "input": "Definition: something described as a clinical trial registry that serves as a publicly available database of clinical trial results.", + "output": "clinical trial results registry (Clinical Trial Registry)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Fatigue 13-Item Scale Version 4 (FACIT-Fatigue 13-Item Version 4) I feel listless (\"washed out\").", + "output": "FAC07003 (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the mitochondrially encoded NADH dehydrogenase 5 (MT-ND5) gene, located in the mitochondria, which encodes for NADH dehydrogenase subunit 5 protein that complex 1, is part of a large enzyme complex active in mitochondria. Mutations at this locus have been identified in patients with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MT-ND5 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Finding described as problem associated with inaccuracies in any written, printed, or graphic matter that is affixed to the device or its packaging with any matter that accompanies the device including verbal instructions related to identification, technical description and use of the device provided by the device manufacturers that is intended for healthcare professionals.", + "output": "Inadequate Instructions for Healthcare Professional (Finding)" + }, + { + "input": "Definition: Chromosome 12 Physical Location described as physical location of ERBB3_Gene", + "output": "12: 54760154-54782854 (Spatial Concept)" + }, + { + "input": "Definition: hydrogen-transporting ATP synthase, F1 sector location described as the catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.", + "output": "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1) (hydrogen-transporting ATP synthase, F1 sector location)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; severe decompensated liver function", + "output": "Grade 4 Hepatitis viral (Finding)" + }, + { + "input": "Definition: Manufactured Object described as containers resembling a sliding box that can be push in and pull out from a structure that are intended for handling money. These drawers typically consist of a metallic box with several compartments that includes a lock, ball bearings, an ejection mechanism, and hold downs to secure the bills. Some cabinets include slots for bills, cards, or other documents and a cable for interfacing with cash register systems. Money handling drawers are available in a variety of sizes, configurations, and colors; they are mainly used as a component of cash registers (e.g., at point of sales).", + "output": "Money Handling Drawers (Casework and Furniture)" + }, + { + "input": "Definition: something described as medical intervention indicated", + "output": "Grade 2 Thromboembolic Event, CTCAE (Thromboembolic Event, CTCAE)" + }, + { + "input": "Definition: something described as human HES5 wild-type allele is located in the vicinity of 1p36.32 and is approximately 2 kb in length. This allele, which encodes transcription factor HES-5 protein, may be involved in the modulation of transcription.", + "output": "Hairy and Enhancer of Split 5, (Drosophila) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Note described as a record detailing decisions and/or clarification of any information relating to the Safety Reporting category.", + "output": "Safe Flnote (Intellectual Product)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the receptor accessory protein 1 (REEP1) gene, located at chromosome 2p11.2, which encodes the protein receptor expression-enhancing protein 1. Genetic variants at this locus have been associated with distal hereditary motor neuronopathy and spastic paraplegia.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, REEP1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Assembly Version described as the source-specific version of the genome assembly. EXAMPLE(S): (Human Genome) Build 35 OTHER NAME(S): NOTE(S):", + "output": "Genome Assembly Version (Assembly Version)" + }, + { + "input": "Definition: Name described as a non-unique textual identifier for the arm. EXAMPLE(S): Treatment A", + "output": "Arm.name (Intellectual Product)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling.", + "output": "downregulation of pulmonary blood vessel remodeling (negative regulation of blood vessel remodeling)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is or was unhappy with their appearance.", + "output": "Unhappy With Appearance (Findings-Based Question)" + }, + { + "input": "Definition: something described as a subdivision of area 9 of Brodmann (guenon) in the guenon based on cytoarchitecture and myeloarchitecture. It is one of four parts of area 9. The others are area 9a of Vogts, area 9b of Vogts and area 9c of Vogts ( Vogts-1919 ).", + "output": "9d (Body Location or Region)" + }, + { + "input": "Definition: Gram Negative Bacteria described as family of gram negative, coccoid microorganisms, in the order Chlamydiales, pathogenic for vertebrates; genera include Chlamydia and Chlamydophila.", + "output": "Family Chlamydiaceae (Phylum Chlamydiae)" + }, + { + "input": "Definition: Organic Chemistry Processes described as the creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.", + "output": "Amination (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Chloral derivative described as a colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics.", + "output": "Product containing chlorobutanol (Industrial Aid)" + }, + { + "input": "Definition: something described as the determination of the amount of levetiracetam present in a sample.", + "output": "DRUG SCRN QUAN LEVETIRACETAM (therapeutic drug assays)" + }, + { + "input": "Definition: something described as the average (mean) duration (time) of the QRS interval, obtained from a set of measurements of the QRS interval. The QRS interval is defined as the time from the beginning of the QRS complex to the end of the QRS complex, representing the time it takes for the ventricles to depolarize.", + "output": "Summary (Mean) QRS Duration (ECG Measurement)" + }, + { + "input": "Definition: negative regulation of animal organ morphogenesis described as any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification.", + "output": "negative regulation of imaginal disc-derived wing vein specification (negative regulation of post-embryonic development)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as mesentery, each instance of which is a fold in some greater omentum that connects some diaphragm with the concave surface of some spleen.", + "output": "Ligamentum lienorenale (Mesentery)" + }, + { + "input": "Definition: Ureterocele described as a ureterocele with a small, obstructive orifice.", + "output": "Obstructive Ureterocele (Ureterocele)" + }, + { + "input": "Definition: Medical Device described as (a) A low-energy DC-defibrillator is a device that delivers into a 50 ohm test load an electrical shock of a maximum of 360 joules of energy used for defibrillating (restoring normal heart rhythm) the atria or ventricles of the heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy defibrillators with a maximum electrical output of less than 360 joules of energy that are used in pediatric defibrillation or in cardiac surgery. The device may either synchronize the shock with the proper phase of the electrocardiogram or may operate asynchronously. The device delivers the electrical shock through paddles placed either directly across the heart or on the surface of the body. (b) A high-energy DC-defibrillator is a device that delivers into a 50 ohm test load an electrical shock of greater than 360 joules of energy used for defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device may either synchronize the shock with the proper phase of the electrocardiogram or may operate asynchronously. The device delivers the electrical shock through paddles placed either directly across the heart or on the surface of the body.", + "output": "Defibrillators, Line-Powered (Manual external defibrillator)" + }, + { + "input": "Definition: Subcellular Fractions described as vesicular fragments of endoplasmic reticulum formed when cells are disrupted.", + "output": "microsome (Subcellular Fractions)" + }, + { + "input": "Definition: something described as ataxia associated with chaotic multidirectional conjugate eye movements secondary to metastatic tumors to cerebellum. The most common malignant tumor associated with this paraneoplastic syndrome is lung carcinoma.", + "output": "Paraneoplastic Opsoclonus-Ataxia (Paraneoplastic Syndromes)" + }, + { + "input": "Definition: Abnormal circulating long-chain fatty-acid concentration described as any deviation from the normal concentration of phytanic acid in the blood circulation.", + "output": "Abnormal circulating phytanic acid level (Finding)" + }, + { + "input": "Definition: filamentous growth of a population of unicellular organisms described as a filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions.", + "output": "growth of unicellular organism as a thread of attached cells (Cell Function)" + }, + { + "input": "Definition: something described as sarcoma that is amenable to surgical resection.", + "output": "Resectable Sarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Food described as a food or dietary supplement that is believed to provide health benefits.", + "output": "Nutriceuticals (Food)" + }, + { + "input": "Definition: Research Activity described as a type of study designed to assess or examine methods of identifying a condition (or risk factors for a condition) in people who are not yet known to have the condition (or risk factor).", + "output": "screening trials (Research Activity)" + }, + { + "input": "Definition: Disorder of nasal cavity described as a non-neoplastic or neoplastic disorder that affects the nasal cavity. Representative examples include inflammatory disorders, papillomas, and carcinomas.", + "output": "Nasal cavity disease NOS (Disorder of nose and nasopharynx)" + }, + { + "input": "Definition: something described as glottic cancer with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.", + "output": "Glottic Cancer pN2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with an apolipoprotein receptor.", + "output": "apolipoprotein receptor binding (Molecular Function)" + }, + { + "input": "Definition: Treatment Vehicle Amount described as the quantity of exposure to an excipient in a treatment.", + "output": "EXVAMT (Treatment Vehicle Amount)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.", + "output": "indolalkylamine catabolic process (indole-containing compound catabolic process)" + }, + { + "input": "Definition: Central Nervous System Embryonal Tumor, Not Otherwise Specified described as a central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.", + "output": "Central Nervous System Embryonal Tumor, NOS with Leptomeningeal Spread (Metastatic Primary Malignant Central Nervous System Neoplasm)" + }, + { + "input": "Definition: Transient Ischemic Attack described as a transient episode of cerebral dysfunction of vascular origin with no persistent neurological deficit.", + "output": "Transient Ischemic Attacks (Central nervous system vascular disorders)" + }, + { + "input": "Definition: Urinary Bladder Diseases described as an abnormal communication between the urinary bladder and the intestine.", + "output": "Intestinovesical fistula NOS (Internal gastrointestinal fistula)" + }, + { + "input": "Definition: galactose catabolic process described as the chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose.", + "output": "beta-D-galactofuranose degradation (beta-D-galactofuranose metabolic process)" + }, + { + "input": "Definition: Medical Device described as ureteral catheters designed for endoscopic incision (ablation) of strictures in the proximal and distal ureter and at the ureteropelvic junction. These catheters typically consist of a 10 Fr tube with radioopaque markers that includes a balloon near its distal tip to define the area of stenosis, and a monopolar electrocautery cutting wire with a small active surface (typically 2.8 cm length); the procedure is usually performed under fluoroscopic guidance. Ablation ureteral catheters are used for the treatment of ureteral obstructions (endoureterotomy) and ureteropelvic junction obstructions (endopyelotomy).", + "output": "Catheters, Urinary, Ureteral, Ablation (Medical Device)" + }, + { + "input": "Definition: something described as a classification of the amount of nut mix IgG antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen.", + "output": "C165913 (Immunoglobulin G measurement)" + }, + { + "input": "Definition: Inflammatory disorder of digestive system described as inflammation of the stomach resulting from alcohol ingestion.", + "output": "Alcoholic Gastritis (Drug-induced gastrointestinal disturbance)" + }, + { + "input": "Definition: Absent epiphyses of the middle phalanges of the hand described as absence of the epiphysis located at the proximal end of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.", + "output": "Absent end part of thumb innermost long bone (Absent epiphyses of the thumb)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in estrogen metabolism.", + "output": "sulfotransferase family 1E member 1 (Gene or Genome)" + }, + { + "input": "Definition: Chromosome 17 Physical Location described as physical location of CNTNAP1_Gene", + "output": "17: 68088158-38105358 (Chromosome 17 Physical Location)" + }, + { + "input": "Definition: Software, Computer-Aided Detection System, Image described as image computer-aided detection system software designed to operate detection systems used to analyze in-vivo images of the spine. These detection systems assess the spine structure (i.e., spine configuration and its abnormalities) from the skin surface without using ionizing radiation. This software can work with personal computers that provide a minimum of the required capabilities; the software performs a variety of algorithms to facilitate the analysis of spinal images taken from the skin. The software is usually supplied with the computer-aided systems and may be updated (i.e., through the release of modified versions) during the life of the system. Spine skin surface image computer-aided detection system software facilitates the analysis of deformities in the sagittal and frontal planes (e.g., segmental angles, perpendicular inclination) and the segmental motion of the spine; it is mainly used to determine the status and progress of spinal disorders, including kyphosis or lordosis of particular spinal areas.", + "output": "Software, Computer-Aided Detection Systems, Image, Spine, Skin Surfacing (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as reagents used in electrophoresis as porous supporting media for the migration of the charged particles. These media include agarose gel films, cellulose acetate sheets, and cellulose paper.", + "output": "IVD Test Reagent/Kits, Electrophoresis, Supporting Media (Medical Device)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a substructure of the medial pulvinar nucleus of the thalamus. It, the Nucleus pulvinaris medialis internus (Hassler), the Nucleus pulvinaris medialis dorsalis (Hassler) and the Nucleus pulvinaris medialis ventralis (Hassler) constitute the Nucleus pulvinaris medialis (Hassler) ( Jones-1990 ).", + "output": "Nucleus pulvinaris medialis zentralis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgery to remove one or more metastases (tumors formed from cells that have spread from the primary tumor). When all metastases are removed, it is called a complete metastasectomy.", + "output": "Metastasectomies (Operative Surgical Procedures)" + }, + { + "input": "Definition: Midbrain and pons described as the middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.", + "output": "Midbrain, NOS (Neuroanatomy)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.", + "output": "response to glucitol (Cell Function)" + }, + { + "input": "Definition: positive regulation of blood circulation described as any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.", + "output": "up regulation of renin secretion into blood stream (positive regulation of blood circulation)" + }, + { + "input": "Definition: Respiratory System described as serous sac, which has as parts the pleura and the pleural cavity. Examples: There are only two canonical instances, right and left pleural sacs.", + "output": "Pleural sac (Lower respiratory system structure)" + }, + { + "input": "Definition: Intellectual Product described as acute Physiology and Chronic Health Evaluation II - Serum potassium (mMol/L).", + "output": "APACHE II - Serum Potassium (APACHE II Clinical Classification Question)" + }, + { + "input": "Definition: something described as a coded value specifying the number of occurrences of an event within a given time period.", + "output": "repeatFrequencyCode (Code)" + }, + { + "input": "Definition: Immunology analyte described as the major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.", + "output": "Interferon, Type II (Immunologic Factor)" + }, + { + "input": "Definition: Medical Device described as enriched culture media in the form of liquids, solids, or semisolids used as a medium capable of supporting the growth of specific mycobacteria. These culture media consist of a base whose physiological mixture is enriched by the addition of nutritional components (e.g., blood, blood serum, vitamins, extracts of plant or animal tissues, hyaluronic acid) required to support the growth of, identify, and study specific mycobacteria. The culture media usually include an antibiotic (e.g., potassium penicillin G) in an amount effective to inhibit growth of contaminating microorganisms. Mycobacteria enriched culture media are used in the diagnosis of disease caused by pathogenic microorganisms.", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Enrichment, Mycobacteria (Medical Device)" + }, + { + "input": "Definition: Breast Diseases described as breast adenosis characterized by the proliferation of acini, a lobulated architectural pattern, and stromal sclerosis. The luminal epithelial and myopepithelial cells are preserved. Microcalcifications and foci of apocrine metaplasia may be present.", + "output": "Sclerosing Adenosis of the Breast (benign breast disorder)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of actin filament-based movement.", + "output": "activation of actin filament-based movement (Cell Function)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi.", + "output": "regulation of termination of mating projection growth (Cell Function)" + }, + { + "input": "Definition: something described as bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective).", + "output": "Wide mandible (Face)" + }, + { + "input": "Definition: Functional system described as a group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).", + "output": "Systema digestorium (Topography Axis)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61502\" active clinical trials using this agent.", + "output": "mapatumumab (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2.", + "output": "1-phenylethanol dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: Lesion described as a pancreatic lesion microscopically resembling pancreatic intraepithelial neoplasia-1A, however the neoplastic nature of the pathologic process has not been unambiguously established.", + "output": "Pancreatic Intraepithelial Neoplasia/Lesion-1A (Lesion)" + }, + { + "input": "Definition: something described as abnormally increased intraepithelial lymphocyte count. This finding may be appreciated as large numbers of surface intraepithelial lymphocytes as seen (for instance) with hematoxylin and eosin staining of a colonic biopsy sample taken during colonoscopy.", + "output": "Lymphocytic infiltration of the colorectal mucosa (Finding)" + }, + { + "input": "Definition: Orthostatic intolerance described as a condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment.", + "output": "Chronic Orthostatic Intolerance (Orthostatic intolerance)" + }, + { + "input": "Definition: Magnetic resonance imaging of abdomen described as magnetic resonance imaging of the abdomen without the use of a contrast agent.", + "output": "Magnetic resonance imaging of abdomen without contrast (MRI without contrast)" + }, + { + "input": "Definition: Molecular Function described as combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.", + "output": "gonadotropin-releasing hormone receptor activity (G-protein coupled receptor activity)" + }, + { + "input": "Definition: Neoplastic Process described as a rare type of basal cell carcinoma. It is characterized by multiple tiny cysts lined by infundibular epithelium.", + "output": "Infundibulocystic Basal Cell Carcinoma (Skin Basal Cell Carcinoma)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Tracheal Mucositis, CTCAE (Tracheal Mucositis, CTCAE)" + }, + { + "input": "Definition: something described as a rare benign vascular neoplasm that arises from the thyroid gland. This category includes hemangiomas, cavernous hemangiomas, and lymphangiomas.", + "output": "Thyroid Gland Benign Vascular Neoplasm (Benign vascular neoplasm)" + }, + { + "input": "Definition: Medical Device described as laboratory light microscopes configured with illumination at the top, the stage below, and optics on the bottom for microscopic study of large specimens by transmitted light. Most inverted-stage microscopes are configured for observation of samples using several contrast methods (e.g., phase contrast). These microscopes are used for examination of tissue cultures in all types of culture vessels (e.g., petri dishes, culture bottles) and in microtest and microtiter plates.", + "output": "Microscopes, Tissue Culture (Medical Device)" + }, + { + "input": "Definition: something described as craig Handicap Assessment and Reporting Technique-Short Form Paper Version - Approximately how much did you pay last year for medical care expenses?", + "output": "CHART-SF Paper Version - Medical Care Expense Last Year (CHART-SF Paper Version Questionnaire Question)" + }, + { + "input": "Definition: something described as the reemergence of an epithelioid malignant peripheral nerve sheath tumor after a period of remission.", + "output": "Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Organism Attribute described as differential variation between males and females in specified areas of development. Limited to human populations.", + "output": "Sex Linked Developmental Differences (Organism Attribute)" + }, + { + "input": "Definition: something described as a morphologic finding indicating the presence of nucleated red cells in the peripheral blood.", + "output": "nucleated rbcs (Finding of red blood cell maturation age)" + }, + { + "input": "Definition: Recurrent Lung Carcinoma Cell Type Unspecified described as the re-emergence of non-small cell lung carcinoma after a period of remission.", + "output": "non-oat cell lung cancer, recurrent (Recurrent Lung Carcinoma Cell Type Unspecified)" + }, + { + "input": "Definition: Female Reproductive System Disorder described as primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity).", + "output": "Endometrial neoplasms malignant (Neoplastic Process)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the lumbar vertebral column.", + "output": "Abnormality of the lumbar spine (Abnormality of the vertebral column)" + }, + { + "input": "Definition: Disease or Syndrome described as an acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)", + "output": "MULTIPLE CHEM SENSITIVITY SYNDROME (Environment related disease)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Has there been a time when you started to do something to make yourself not alive anymore (end your life or kill yourself) but someone or something stopped you before you actually did anything? What did you do? (Past 3 Months).", + "output": "CSS10-Interrupted Attempt-P3M (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as disability Assessment for Dementia - Sub-Total Planning & Organization.", + "output": "DAD0143 (Intellectual Product)" + }, + { + "input": "Definition: Gastroparesis, CTCAE described as weight loss >=20% from baseline; tube feeding or TPN indicated; elective operative intervention indicated", + "output": "Grade 3 Gastroparesis, CTCAE (Gastroparesis, CTCAE)" + }, + { + "input": "Definition: Metal Ion Binding described as copper Chelation involves non-covalent coordination bonding between copper and an organic chemical, often as part of an enzyme.", + "output": "Copper Chelation (Molecular Function)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as a branch of neurology concerned with the chemistry of the nervous system.", + "output": "Science of neurochemistry (Neurosciences)" + }, + { + "input": "Definition: Disease or Syndrome described as this syndrome is characterized by the association of hypogonadotropic hypogonadism (with primary amenorrhea and lack of secondary sexual development) and retinitis pigmentosa. It has been described in two sisters born to nonconsanguineous parents.", + "output": "Hypogonadotropic hypogonadism retinitis pigmentosa syndrome (Retinitis Pigmentosa)" + }, + { + "input": "Definition: negative regulation of proteolysis described as any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.", + "output": "negative regulation of peptidolysis involved in cellular protein catabolic process (negative regulation of proteolysis)" + }, + { + "input": "Definition: Myeloid Leukemia described as leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.", + "output": "Myelocytic leukaemia (Myeloid Leukemia)" + }, + { + "input": "Definition: Biological macromolecule described as proteins that form the structure of the NUCLEAR PORE. They are involved in active, facilitated and passive transport of molecules in and out of the CELL NUCLEUS.", + "output": "Nuclear Pore Complex Proteins (Nucleocytoplasmic Transport Proteins)" + }, + { + "input": "Definition: something described as an organization which aims to earn profit through its operations and is concerned with its own interests.", + "output": "Corporation (Organization)" + }, + { + "input": "Definition: Fetal Diseases described as death of a fetus after 10 weeks gestation.", + "output": "INTRAUTERINE FETAL DEMISE (Obstetric Delivery)" + }, + { + "input": "Definition: Homeopathic remedies letter A described as hemlock spruce.", + "output": "Abies canadensis, homeopathic preparation (Organic Chemical)" + }, + { + "input": "Definition: Photosensitizing Agents described as a metal complex compound of phthalocyanide with photosensitizing activity. Upon injection with photocyanide and subsequent introduction to photodynamic therapy (PDT), photocyanide becomes activated and forms reactive oxygen species that induce apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90535\" active clinical trials using this agent.", + "output": "photocyanine (Pharmacologic Substance)" + }, + { + "input": "Definition: adenosine deaminase activity described as catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.", + "output": "double-stranded RNA adenosine deaminase activity (adenosine deaminase activity)" + }, + { + "input": "Definition: Metastatic Neuroendocrine Neoplasm described as a neuroendocrine neoplasm that arises from the lung and has spread to another anatomic site.", + "output": "Metastatic Lung Neuroendocrine Neoplasm (Malignant neoplasm of lung)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the resolution of Holliday junctions.", + "output": "Holliday junction resolvase (Gene or Genome)" + }, + { + "input": "Definition: Drugs used in the treatment of paracetamol poisoning described as a kind of amino acid", + "output": "(S)-methionine (Amino acid supplement)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene, located at chromosome 5q32, which encodes for a trypsin inhibitor that may prevent trypsin-catalyzed premature activation of zymogens. This inherited genetic mutation has been identified in patients with chronic pancreatitis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SPINK1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Medical Device described as needles designed for aspirating fluids from and/or irrigating body cavities. These devices may consist of double-lumen blunt needles for simultaneous aspiration and irrigation or single-lumen needles to perform irrigation and aspiration sequentially.", + "output": "Irrigation/Aspiration Needles (Needle device)" + }, + { + "input": "Definition: something described as human XAF1 is located in the vicinity of 17p13.2 and is approximately 20 kb in length. This gene, which encodes XIAP-associated factor 1 protein, is involved in apoptosis and caspase inhibition.", + "output": "XAF1 wt Allele (XAF1 gene)" + }, + { + "input": "Definition: Functional Concept described as release of the substance(s) in a way that is unknown or not specified.", + "output": "Unknown Mechanism of Action (Functional Concept)" + }, + { + "input": "Definition: Arteries described as two series of blood vessels that supply the lungs with nutrients. The right side bronchial arteries arise from the first aortic intercostal while the left side arises from thoracic aorta.", + "output": "Bronchial Arteries (Intrathoracic systemic artery)" + }, + { + "input": "Definition: Procedure categorized by device involved described as delivery of enteral nutrition via a tube placed into the stomach, duodenum, or jejunum.", + "output": "Tube feeding of patient (diet route/schedule)" + }, + { + "input": "Definition: Biologically Active Substance described as a transfer RNA which is specific for carrying isoleucine to sites on the ribosomes in preparation for protein synthesis.", + "output": "Transfer RNA, Ile (RNA, Transfer, Amino Acid-Specific)" + }, + { + "input": "Definition: Intellectual Product described as a standardized 31-item questionnaire, developed by Booth et al. in 2000, that is administered over the telephone and assesses physical activity lasting at least 10 minutes during the past seven days.", + "output": "IPAQ Long Last 7 Days Telephone Format Version (Intellectual Product)" + }, + { + "input": "Definition: something described as the Short Form 36 Health Survey Standard, US Version 2.0 (SF36 v2.0 Standard) Question 2.", + "output": "SF-36 v2.0 Standard - Question 2 (Intellectual Product)" + }, + { + "input": "Definition: regulation of heat dissipation described as any process that stops, prevents, or reduces the rate or extent of heat dissipation.", + "output": "down-regulation of heat dissipation (Organism Function)" + }, + { + "input": "Definition: Chlamydiaceae described as any bacteria that is not assigned to the species level but can be assigned to the Chlamydophila genus level.", + "output": "Chlamydophila species (Chlamydiales)" + }, + { + "input": "Definition: Organ or Tissue Function described as observable or measurable characteristics of nutrition.", + "output": "Nutrition Phenomena (Organ or Tissue Function)" + }, + { + "input": "Definition: Molecular Function described as any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).", + "output": "NAD salvage (Molecular Function)" + }, + { + "input": "Definition: Staphylococcus schleiferi subsp. schleiferi described as a subspecies of Staphylococcus schleiferi that is coagulase tube test positive, produces betahemolysin and a heat-stable nuclease but not a clumping factor. This subspecies has not been isolated from humans.", + "output": "Staphylococcus schleiferi ss coagulans (Staphylococcus schleiferi subsp. schleiferi)" + }, + { + "input": "Definition: Skeletal muscle structure described as the musculotendinous sheath formed by the supraspinatus, infraspinatus, subscapularis, and teres minor muscles. These help stabilize the HUMERAL HEAD in the GLENOID CAVITY of the SCAPULA and allow for rotation of the SHOULDER JOINT about its longitudinal axis.", + "output": "Structure of rotator cuff including muscles and tendons (Skeletal muscle structure)" + }, + { + "input": "Definition: cyanuric acid metabolic process described as the chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides.", + "output": "cyanuric acid breakdown (cyanuric acid metabolic process)" + }, + { + "input": "Definition: Enzyme described as dexamethasone-induced Ras-related protein 1 (281 aa, ~32 kDa) is encoded by the human RASD1 gene. This protein is involved in small GTPase activity stimulated by nitric oxide signaling.", + "output": "RAS-Related Protein (RAS Superfamily Proteins)" + }, + { + "input": "Definition: Document type described as one of several distinct subdivisions of a text intended to separate ideas.", + "output": "Paragraph (Document type)" + }, + { + "input": "Definition: RPQ Questionnaire Question described as rivermead Post-Concussion Symptoms Questionnaire (RPQ) Compared with before the accident, do you now suffer from: Feelings of dizziness.", + "output": "RPQ01-Feelings of Dizziness (RPQ Questionnaire Question)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH.", + "output": "10-formyltetrahydrofolate:NADP+ oxidoreductase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Thyroid Diseases described as a morphologic finding indicating transformation of follicular cells to large cells with abundant eosinophilic and granular cytoplasm (Hurthle cells) in the thyroid gland.", + "output": "Hurthle cell metaplasia of thyroid (Lesion of neck)" + }, + { + "input": "Definition: something described as a carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.", + "output": "Lung Carcinoma, Lewis (Undifferentiated carcinoma)" + }, + { + "input": "Definition: Finding described as presumed deficiency of brain-derived neurotropic factor (BDNF), associated with loss-of-function mutation(s) in the BDNF gene.", + "output": "BDNF Deficiency (Finding)" + }, + { + "input": "Definition: something described as reinforcing an ethnic group identity and distinctness by emphasizing the traits that set its members apart from others, rather than what they share in common.", + "output": "Ethnic Boundary Maintenances (Group Attribute)" + }, + { + "input": "Definition: something described as TPN or hospitalization indicated; invasive intervention indicated", + "output": "Grade 3 Anal necrosis (Finding)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process.", + "output": "down-regulation of o-orsellinic acid biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Finding described as death of the patient due to the toxic side effects of induction therapy.", + "output": "Death After Induction Therapy (Finding)" + }, + { + "input": "Definition: something described as a malignant squamous cell which produces extracellular keratin.", + "output": "Well Differentiated Malignant Squamous Cell (Cell)" + }, + { + "input": "Definition: Gastrointestinal Hemorrhage described as passage of many stools containing blood. []", + "output": "DIARRHEA, BLOODY (character of diarrhea)" + }, + { + "input": "Definition: something described as the determination of the amount of the intestinal specific alkaline phosphatase in a biological specimen.", + "output": "Intestinal Specific Alkaline Phosphatase Measurement (Alkaline phosphatase measurement)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176.", + "output": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells (T-cell Receptor-engineered T-cells)" + }, + { + "input": "Definition: something described as discipline concerned with the ethical and social implications of biological research and medicine.", + "output": "Ethics, Biomedical (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: something described as an order comprising four families of eukaryotic viruses possessing linear, non-segmented, negative-strand RNA genomes. The families are BORNAVIRIDAE; FILOVIRIDAE; PARAMYXOVIRIDAE; and RHABDOVIRIDAE.", + "output": "Order Mononegavirales (RNA Viruses)" + }, + { + "input": "Definition: Spatial Concept described as the four compass directions: northeast, southeast, southwest, and northwest, located halfway between the cardinal directions.", + "output": "Ordinal Direction (Spatial Concept)" + }, + { + "input": "Definition: something described as the date (and time) on which the activity was ordered. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "PerformedActivity.orderDate (Order Date)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA.", + "output": "5-methylcytosine anabolism (pyrimidine-containing compound biosynthetic process)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.", + "output": "regulation of nucleotide catabolism (regulation of cellular catabolic process)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Have you taken any steps towards making a suicide attempt or preparing to kill yourself (such as collecting pills, getting a gun, giving valuables away or writing a suicide note)? (Past X Years).", + "output": "C-SSRS Baseline/Screening Version - Preparatory Acts or Behaviors Toward Suicide Attempt (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as ironwood.", + "output": "Ostrya virginica / ironwood (Homeopathic remedies letter O)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "output": "cardioblast cell fate commitment (Cell Function)" + }, + { + "input": "Definition: Databases described as a database in which all errors have been detected and resolved.", + "output": "clean database (Databases)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual usually is or was in some degree of pain.", + "output": "I am usually in some degree of pain (Intellectual Product)" + }, + { + "input": "Definition: Care plan described as therapy that uses the creative work of clients for emotional expression, sublimation, achievement, and to reveal underlying conflicts.", + "output": "Art therapy (regime/therapy)(procedure) (creative arts therapy)" + }, + { + "input": "Definition: regulation of leukocyte activation described as any process that modulates the frequency, rate, or extent of mast cell activation.", + "output": "regulation of mast cell activation (Cell Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.", + "output": "Carfilzomib product (Antineoplastic Agents)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine CA 195, a blood group carbohydrate-related tumor marker. The detection of the tumor marker CA 195 is mostly used in diagnosis and monitoring of colorectal and pancreatic carcinomas.", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Carbohydrate Antigen CA 195 (Medical Device)" + }, + { + "input": "Definition: something described as a synthetic compound of the polyamine class of chemicals with potential antineoplastic activity. Natural endogenous polyamines bind to DNA and are involved in a number of cellular processes such as cell division, differentiation, and membrane function. SL11093 displaces these polyamines from their DNA binding sites, resulting in cessation of cell growth and cell death.", + "output": "SL 11093 (Pharmacologic Substance)" + }, + { + "input": "Definition: Anatomical line described as a group of muscles attached to the SOFT PALATE (or velum) and the PHARYNX. They include the superior constrictor, the PALATOPHARYNGEUS, the levator veli palatini muscle, and the muscularis uvulae. This sphincter is situated between the oral and nasal cavities. A competent velopharyngeal sphincter is essential for normal speech and swallowing.", + "output": "Posterior fascicle of palatopharyngeus (Superior pharyngeal constrictor muscle structure)" + }, + { + "input": "Definition: Professional or Occupational Group described as a person of contact that denotes where, and to whom pharmaceuticals are to be shipped. The person is assigned by the principal investigator and registered with the NCI CTEP Pharmaceutical Management Branch (PMB) as a distributor of investigational new drugs (INDs) for all NCI-sponsored trials. Additionally, this person is authorized to place orders for investigational agents with PMB, requests drug transfers, and maintains drug inventory documentation at the clinical site. Investigational agents are shipped from the PMB directly to the institution or the investigator's practice site where the agent will be prepared and administered.", + "output": "Shipping Designee (Professional or Occupational Group)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in memory T-cell function.", + "output": "FIBROLEUKIN (Genes, Regulator)" + }, + { + "input": "Definition: Recurrent joint dislocation described as dislocation of a given joint repeated times. []", + "output": "recurrent dislocation (Dislocations)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 4, Word 1.", + "output": "ADNI AVLT - List A Recall 4 Word 1 (Intellectual Product)" + }, + { + "input": "Definition: something described as a question about an individual's current self-care ability with washing or dressing.", + "output": "Washing or Dressing Self-Care Today (Intellectual Product)" + }, + { + "input": "Definition: Skin Abnormalities described as any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.", + "output": "icthyosis (Keratosis)" + }, + { + "input": "Definition: Delusional disorder described as mild paranoia in nonpsychotic persons.", + "output": "Paranoid disorder (Mental and Behavioral Signs and Symptoms)" + }, + { + "input": "Definition: something described as a measurement of the mast cells in a biological specimen.", + "output": "Mast Cell Count (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as an indication of the percentage of cancerous cells present in the tissue core with the greatest amount of tumor involvement.", + "output": "Greatest Percentage of Core Involvement by Cancer in Any Core (Other Finding)" + }, + { + "input": "Definition: Molecular Function described as the addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.", + "output": "RNA polyadenylation (RNA 3' End Processing)" + }, + { + "input": "Definition: Cardiovascular Diseases described as a syndrome resulting from structural defects of the arteries that arise from the aortic arch. Signs and symptoms include weakness, dizziness, arm numbness, blurred vision and transient ischemic attacks.", + "output": "Aortic Arch Syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Finding described as a unilateral form of ptosis.", + "output": "Ptosis, unilateral (Eye)" + }, + { + "input": "Definition: something described as having to do with the ability to think and reason. This includes the ability to concentrate, remember things, process information, learn, speak, and understand.", + "output": "Neurocognitive (Physiologic Health)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate.", + "output": "ATP:xylitol 5-phosphotransferase activity (kinase activity)" + }, + { + "input": "Definition: Research Activity described as simultaneous presentation of separate two-dimensional pictures (taken from slightly different angles) to each eye of one subject, resulting in a perception of depth.", + "output": "Stereoscopic Presentation (Research Activity)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as mechanical or anoxic trauma incurred by the infant during labor or delivery.", + "output": "birthing trauma (Traumatic and/or non-traumatic injury of anatomical site)" + }, + { + "input": "Definition: Appendiceal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7 described as appendiceal carcinoma in which regional lymph nodes cannot be assessed.", + "output": "Appendiceal Carcinoma pNX TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as this gene plays a role in lipid modification.", + "output": "SPTLC1 Gene (Gene or Genome)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agentinhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78831\" active clinical trials using this agent.", + "output": "androstane steroid HE3235 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a hammer-shaped bone, part of three interconnected small bones located in the middle ear. It is attached to the inner surface of the tympanic membrane and its function is to transmit sound vibrations.", + "output": "ear hammer (Malleus)" + }, + { + "input": "Definition: Upper facial depth line described as upper facial line bounded by nasion and right tragion.", + "output": "Right upper third facial depth line (Upper facial depth line)" + }, + { + "input": "Definition: something described as a group of cells between the ethmoid nucleus of the thalamus and the anterior pretectal nucleus in the pretectal region of the mouse ( Paxinos-2001 ).", + "output": "scaphoid thalamic nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Organ component cluster described as a tiny, round cluster of blood vessels within the kidneys. It filters the blood to reabsorb useful materials and remove waste as urine.", + "output": "Glomerular (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Functional Concept described as neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include G-protein coupled receptors (GPCRs) and ligand-gated ion channels. The biogenic amines are neurotransmitters derived from amino acids, and include dopamine, epinephrine, GABA, histamine and serotonin. For each of these, decarboxylation of an amino acid is a key step. GABA, gamma-aminobutyric acid, is a key inhibitory neurotransmitter and is synthesized through the decarboxylation of glutamate in a single step. Glutamate is itself an abundant excitatory neurotransmitter. Histamine signals are involved in inflammation and acid secretion in the stomach, acting through GPCRs. Histamine is synthesized in a single step from the amino acid histidine through decarboxylation. Serotonin is a neurotransmitter with a large range of effects, including roles in mood and depression, and is synthesized by first adding a hydroxyl group to tryptophan, followed by decarboxylation. A common mechanism of antidepressant action is to block the reuptake of serotonin at synapses. Dopamine is involved in movement and mood and is derived from tyrosine through addition of a hydroxyl group and decarboxylation. Additional reactions create norepinephrine and epinephrine from dopamine. These molecules, also called adrenalin and noradrenalin, act on the adrenergic receptors to exert responses including alteration of blood pressure, heart rate, metabolic activity, and bronchodilation. Many common drugs such as asthma and heart pressure medications act on adrenergic receptors. Alterations in these biosynthetic pathways can lead to significant clinical consequences. For example, deficiency in tyrosine hydroxylase activity leads to a movement disorder similar to Parkinson's disease and may play a role in Parkinson's disease and the development of an autoimmune response against glutamate decarboxylase (GAD) may trigger the destruction of insulin-secreting cells and type I diabetes. Numerous studies have searched for a potential genetic role of tryptophan hydroxylase mutations in neuropsychiatric indications, with conflicting results.", + "output": "Neurotransmitter Biosynthesis Pathway (Functional Concept)" + }, + { + "input": "Definition: Neural Tube Defects described as a congenital abnormality in which the meninges protrude through a defect in the spinal column or the cranium.", + "output": "Congenital hernia dura mater (Central nervous system disorders congenital NEC)" + }, + { + "input": "Definition: Epithelial Microvillus described as an actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.", + "output": "Stereovillus (Cilia)" + }, + { + "input": "Definition: Finding described as a scar/healing of the myometrium that occurs after uterine injury or after non-cesarean surgery.", + "output": "Non-Cesarean Uterine Surgery Scar (Finding)" + }, + { + "input": "Definition: Temporal Concept described as every fifteen hours.", + "output": "Every Fifteen Hours (Schedule Frequency)" + }, + { + "input": "Definition: something described as a specific population of pluripotent killer (PIK) T-cells that have been induced to express high levels of antibodies against human epidermal growth factor receptor 2 (ERBB2; HER2), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-HER2 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies targeting HER2 expressed on the surface of tumor cells. This may inhibit HER2-dependent signaling, which may lead to inhibition of cellular proliferation and differentiation. Additionally, these cells may stimulate the host immune system to mount both a highly-specific cytotoxic T-lymphocyte (CTL) response and antibody-dependent cell cytotoxicity (ADCC) directed against HER2-overexpressing tumors, which leads to tumor cell lysis. HER2 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and is frequently overexpressed in solid tumors.", + "output": "anti-HER2 antibody expressing pluripotent killer T cells (Cell)" + }, + { + "input": "Definition: Oxidoreductase described as reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.", + "output": "Methionine Sulfoxide Reductases (Selenoproteins)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.", + "output": "regulation of synaptic transmission, dopaminergic (modulation of chemical synaptic transmission)" + }, + { + "input": "Definition: something described as stage IIIB includes: T3b, N0, M0. T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "FIGO stage IIIB carcinoma of fallopian tube (Stage III Fallopian Tube Cancer AJCC v7)" + }, + { + "input": "Definition: Gene or Genome described as human NFIC wild-type allele is located in the vicinity if 19p13.3 and is approximately 104 kb in length. This allele, which encodes nuclear factor 1 C-type protein, plays a role in both the modulation of transcription by RNA polymerase II and the activation of DNA replication.", + "output": "MGC20153 (Gene or Genome)" + }, + { + "input": "Definition: Disorder of hip joint described as coxa vara includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees.", + "output": "Coxa Varas (Deformity of hip joint)" + }, + { + "input": "Definition: something described as receptor-type tyrosine-protein phosphatase epsilon (700 aa, ~81 kDa) is encoded by the human PTPRE gene. This protein plays a role in cytokine production, protein dephosphorylation and red blood cell morphology.", + "output": "RPTPe (Enzyme)" + }, + { + "input": "Definition: Antibody described as a measurement of the HIV-2 virus antibody in a biological specimen.", + "output": "Assay for Human immunodeficiency virus 2 (HIV-2) antibody (Laboratory Procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as histone H2B type 3-B (126 aa, ~14 kDa) is encoded by the human H2BU1 gene. This protein plays a role in chromosome structure condensation.", + "output": "HIST3H2BB (Histone H2b)" + }, + { + "input": "Definition: QIDS-C Clinical Classification Question described as quick Inventory of Depressive Symptomatology - Clinician-Rated - Please circle one response to each item that best describes the patient for the last seven days: Sleep onset insomnia.", + "output": "QIDS-C - Sleep Onset Insomnia (QIDS-C Clinical Classification Question)" + }, + { + "input": "Definition: autotransporter activity described as enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively.", + "output": "hemaglutinin autotransporter activity (autotransporter activity)" + }, + { + "input": "Definition: Educational Status described as indicates a person has attended high school but did not complete high school and did not receive a high school diploma.", + "output": "Some High School Completion (Organism Attribute)" + }, + { + "input": "Definition: Professional or Occupational Group described as an organization who takes part in the distribution chain for a product, as it is moved from its producer to the ultimate consumer. NOTE(S): In this sense, the retailer is a distributor as well, the last one.", + "output": "Distributor (Persons)" + }, + { + "input": "Definition: Polypeptide Hormones described as a 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.", + "output": "apM 1 Protein (Adipokines)" + }, + { + "input": "Definition: Mycobacteriaceae described as genus of gram positive, aerobic bacteria; most species are free living in soil and water, but the major habitat for some is the diseased tissue of warm blooded hosts.", + "output": "MYCOBACT (Immunology)" + }, + { + "input": "Definition: Abnormal size of the dental root described as short dental root.", + "output": "Underdeveloped dental roots (Finding)" + }, + { + "input": "Definition: Medullary carcinoma of thyroid described as a non-hereditary medullary carcinoma of the thyroid gland not associated with multiple endocrine neoplasia. The majority of thyroid gland medullary carcinomas are sporadic.", + "output": "Sporadic Thyroid Gland Medullary Carcinoma (Medullary carcinoma of thyroid)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the monocytes and macrophages to total leukocytes in a biological specimen.", + "output": "MONMPHLE (Laboratory Procedure)" + }, + { + "input": "Definition: Pain described as pain in and around the anus or rectum (perianal region).", + "output": "Anal pain (Sign or Symptom)" + }, + { + "input": "Definition: Finding described as obesity with a body mass index of 35 to 39.9 kg per square meter. []", + "output": "Obesity grade 2 (Obesity, CTCAE)" + }, + { + "input": "Definition: Laboratory Procedure described as a mass spectrometry method in which chemically purified samples are heated to create positively ionized atoms that are then accelerated by an electric field and mass separated by an electromagnet.", + "output": "TIMS (Mass Spectrometry)" + }, + { + "input": "Definition: urate metabolic process described as the chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine.", + "output": "urate catabolic process (purine-containing compound catabolic process)" + }, + { + "input": "Definition: Disease or Syndrome described as a cluster of closely related metabolic abnormalities associated with insulin resistance that confer an increased risk of the development of type 2 diabetes and cardiovascular disease. These abnormalities may include obesity, high blood pressure, abnormal cholesterol levels, proteinuria, and/or polycystic ovary syndrome.", + "output": "Insulin resistance syndrome (Disorder of endocrine pancreas)" + }, + { + "input": "Definition: Organic Chemical described as brand name of a personal lubricant", + "output": "K-Y Jelly (Branded drug names K)" + }, + { + "input": "Definition: Genetic Engineering described as genetic engineering or molecular biology techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.", + "output": "Editing, Gene (Molecular Genetic Technique)" + }, + { + "input": "Definition: Pyrrolidines described as a synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29078\" active clinical trials using this agent.", + "output": "Product containing glycopyrrolate (Antispasmodics, Gastrointestinal)" + }, + { + "input": "Definition: Assessment Estimate Anticipated Indicator described as specifies whether the overall status of the study is an estimate. EXAMPLE(S): OTHER NAME(S): NOTE(S): BRIDG SCC has made the decision to add an anticipatedIndicator until we learn the business rules of how the overall study status could be derived.", + "output": "Study Overall Status Anticipated Indicator (Qualitative Concept)" + }, + { + "input": "Definition: regulation of pharynx morphogenesis described as any process that activates or increases the frequency, rate or extent of pharynx morphogenesis.", + "output": "positive regulation of pharynx morphogenesis (regulation of pharynx morphogenesis)" + }, + { + "input": "Definition: Identifier described as the unique symbol that establishes identity of the observation result.", + "output": "Performed Observation Result Identifier (Intellectual Product)" + }, + { + "input": "Definition: something described as any sound which is unwanted or interferes with HEARING other sounds.", + "output": "NOISE (Poisoning, Toxicology, Environmental Health)" + }, + { + "input": "Definition: something described as a series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.", + "output": "transforming growth factor beta receptor signalling pathway involved in heart jogging (transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry)" + }, + { + "input": "Definition: Inflammatory disorder of lower respiratory tract described as INFLAMMATION of the TRACHEA that is usually associated with RESPIRATORY TRACT INFECTIONS.", + "output": "Tracheitis, NOS (Upper respiratory tract infections NEC)" + }, + { + "input": "Definition: Central Nervous System described as production of sounds by means of vocal cord vibrations.", + "output": "Vocalizes (Speech finding)" + }, + { + "input": "Definition: Molecular Function described as the removal of ADP-ribose from ADP-ribosylglutamate.", + "output": "peptidyl-glutamate ADP-deribosylation (protein de-ADP-ribosylation)" + }, + { + "input": "Definition: Group Attribute described as the inability to meet basic human needs, such as food, shelter, and avoidance of disease.", + "output": "Poverty, Extreme (Group Attribute)" + }, + { + "input": "Definition: something described as the opening of the archenteron, central cavity of gastrula, which is formed by invagination of the BLASTULA or BLASTOCYST. Archenteron gives rise to the alimentary canal of the DIGESTIVE SYSTEM.", + "output": "Blastopores (Embryonic Structure)" + }, + { + "input": "Definition: something described as a cytogenetic abnormality that refers to deletion of chromosome bands 13-14 on the short arm of chromosome 3.", + "output": "del(3)(p13;p14) (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Non-site specific vascular disorders NEC described as rare, progressive inherited disorder resulting from extensive basophilic degeneration of elastic tissue, usually presenting after puberty and involving the skin, eye, and cardiovascular system.", + "output": "ELASTOSIS DYSTROPHICA SYNDROME (Degenerative disorder)" + }, + { + "input": "Definition: Semi-solid dose form described as a semi-solid dose form of homogeneous appearance consisting of a lipophilic phase and an aqueous phase, one of which is finely dispersed in the other. Active substance(s) are dissolved or dispersed in the basis, which may be hydrophilic or hydrophobic.", + "output": "Cream Dose Form (Cutaneous AND/OR transdermal dosage form)" + }, + { + "input": "Definition: regulation of convergent extension involved in rhombomere morphogenesis described as any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis.", + "output": "positive regulation of convergent extension involved in rhombomere morphogenesis (positive regulation of convergent extension involved in gastrulation)" + }, + { + "input": "Definition: Quantitative Concept described as days times micromoles per liter (area under the curve), divided by kilograms (weight) or days times nanomoles per liter (area under the curve), divided by grams (weight).", + "output": "d.umol/l/kg (Quantitative Concept)" + }, + { + "input": "Definition: pT1 stage described as a pathologic primary tumor TNM stage finding. The definition of pT1c stage finding depends on the particular type of cancer that it refers to; for example, for breast cancer, pT1c stage finding is defined as follows: cancer with tumor size more than 1.0 cm, but not more than 2.0 cm in greatest dimension; for fallopian tube cancer, pT1c stage finding is defined as follows: cancer with tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings.", + "output": "pT1c Primary Tumor Finding (Finding)" + }, + { + "input": "Definition: Hospitals described as hospitals located in metropolitan areas.", + "output": "city hospitals (Health Care Related Organization)" + }, + { + "input": "Definition: GOLM2 gene described as human CASC4 wild-type allele is located in the vicinity of 15q15.3 and is approximately 127 kb in length. This allele, which encodes protein CASC4, may be involved in tumor progression and Golgi activity. Aberrant expression of the gene is seen in tumors that overexpress the ERBB2 gene.", + "output": "H63 (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Level 1 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, difficulty with initiating and maintaining respiration; fourth, depression of muscle tone.", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 1 Neonatal Encephalopathy (Intellectual Product)" + }, + { + "input": "Definition: Cytochrome P450 described as sterol 26-hydroxylase, mitochondrial (531 aa, ~60 kDa) is encoded by the human CYP27A1 gene. This protein is involved in cholesterol homeostasis and bile synthesis.", + "output": "Cytochrome P-450C27/25 (Enzyme)" + }, + { + "input": "Definition: something described as a subjective score of 3 on a scale that ranges from 0: Health problems had no effect on my daily activities to 10: Health problems completely prevented me from doing my daily activities.", + "output": "Health Problems Effect on Daily Activities Score 3 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: positive regulation of phosphorus metabolic process described as any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process.", + "output": "upregulation of tatiopterin metabolic process (regulation of tatiopterin metabolic process)" + }, + { + "input": "Definition: Tenebrioninae described as a genus of beetles which infests grain products. Its larva is called mealworm.", + "output": "Tenebrio (Tenebrioninae)" + }, + { + "input": "Definition: something described as a numeric value that estimates the risk of development of a specified neoplastic disease that is based on weighted regression analysis of disease-specific gene variants at multiple genetic loci.", + "output": "Polygenic Risk Score (Risk Estimate)" + }, + { + "input": "Definition: Hereditary thrombocytopenic disorder described as a rare, autosomal recessive bleeding disorder characterized by deficiency or absence of the Ib/IX/V complex on the surface of platelets. It results in thrombocytopenia, prolonged bleeding and the presence of giant platelets.", + "output": "BERNARD-SOULIER SYNDROME (Glycoprotein Ib defect)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on Xp", + "output": "Xp11.4-p11.21 (Cell Component)" + }, + { + "input": "Definition: response to ketone described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.", + "output": "response to corticosterone stimulus (response to mineralocorticoid)" + }, + { + "input": "Definition: something described as human MIR133A1 wild-type allele is located in the vicinity of 18q11.2 and is 87 bases in length. This allele, which encodes MIR133A1 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with the development of squamous cell carcinoma of the tongue as well as cardiac hypertrophy and cardiomyopathy.", + "output": "hsa-mir-133a-1 (MIR133A1 gene)" + }, + { + "input": "Definition: drug paraphernalia described as pipes for smoking tobacco, cannabis, and other substances, in which smoke is drawn through water. Do not confuse with SMOKING PIPES.", + "output": "Narghiles (Manufactured Object)" + }, + { + "input": "Definition: Finding described as breast cancer with metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in ipsilateral internal mammary nodes in the absence of axillary lymph node metastases.", + "output": "Breast Carcinoma cN2 TNM Finding v8 (Breast Cancer Clinical Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as teaching clients in a group setting behavior control and/or modification techniques to manage their behaviors. Service is billed in 60-minute increments per client.", + "output": "Behavior management education group each 60 minutes (mental health counseling)" + }, + { + "input": "Definition: social influences described as attitude or opinion which predisposes an individual to make a preconceived judgment prior to objective evaluation; frequently an irrational attitude of hostility directed against an individual, group, or race or their supposed characteristics; do not confuse with BIAS.", + "output": "Prejudice (Psychology, Social)" + }, + { + "input": "Definition: something described as regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.", + "output": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels (voltage-gated calcium channel activity)" + }, + { + "input": "Definition: something described as capable of being taken away.", + "output": "Removable (General Qualifier)" + }, + { + "input": "Definition: something described as human TRAIP wild-type allele is located in the vicinity of 3p21.31 and is approximately 28 kb in length. This allele, which encodes E3 ubiquitin-protein ligase TRAIP protein, is involved in the ubiquitination of protein substrates.", + "output": "TRAF Interacting Protein wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Lesion of bronchus described as an abnormal passage or communication between a bronchus and another part of the body.", + "output": "Fistula bronchial (pathologic fistula)" + }, + { + "input": "Definition: Abnormal nervous system physiology described as a sensation similar to an electrical shock radiating from the back of the head down the spine as the neck is bent forward.", + "output": "Barber chair sign (Neurologic Symptoms)" + }, + { + "input": "Definition: something described as bags designed to store liquids to be delivered into the rectum for the purposes of stimulating defecation (i.e., enema). These bags typically consist of a flexible plastic, calibrated container with a self-closing valve and a plastic tube attachment that permits the solution to drain quickly and completely. These bags are frequently part of an enema kit that also includes lubricated tips, clamps, waterproof underpads, and soap. Dedicated enema bags for use for infants and children are available.", + "output": "Enema Bags (Medical Device)" + }, + { + "input": "Definition: something described as a score for graft versus host disease based on features of skin involvement.", + "output": "GvHD Skin Features Score (Intellectual Product)" + }, + { + "input": "Definition: Organ or Tissue Function described as determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.", + "output": "adult salivary gland boundary specification (Organ or Tissue Function)" + }, + { + "input": "Definition: Body Location or Region described as anatomical coordinate which is a plane, line or point defined with reference to visible or palpable organ parts; used as a reference in establishing the location and measurement of organ, organ parts or body spaces. Examples: Transpyloric plane, T4 level, midclavicular line, McBurney's point.", + "output": "Anatomical qualitative coordinate (Body Location or Region)" + }, + { + "input": "Definition: Finding described as a lesion that arises in a peripheral site (e.g., limbs, fingers, or ears).", + "output": "Acral Lesion (Finding)" + }, + { + "input": "Definition: something described as subdivision of trunk that consists of those organs that separate the body cavity from the body's exterior; together with the body cavity and its contents, the body wall constitutes the trunk (one of the principal body parts). Examples: There is only one body wall.", + "output": "Trunk wall (Region of trunk)" + }, + { + "input": "Definition: Angiosperm described as a class of vascular plants which produce flowers and seeds. They include monocotyledons, dicotyledons, and about 80% of all known plant species.", + "output": "Hamamelididae (Tracheophyta)" + }, + { + "input": "Definition: Stage IV Indolent Adult Non-Hodgkin Lymphoma described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.", + "output": "Marginal zone lymphoma stage IV (Marginal Zone B-Cell Lymphoma)" + }, + { + "input": "Definition: Finding described as an assessment of an individual's oral impairment during swallowing.", + "output": "Oral Impairment (Other Finding)" + }, + { + "input": "Definition: Organic Chemical described as the hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1837\" active clinical trials using this agent.", + "output": "Paroxetine hydrochloride (Antidepressive Agents)" + }, + { + "input": "Definition: Absent epiphyses of the phalanges of the hand described as absence of one or more epiphyses of the 5th finger.", + "output": "Absent end part of little finger bone (Abnormality of the epiphyses of the 5th finger)" + }, + { + "input": "Definition: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor described as catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N.", + "output": "isopenicillin N synthetase activity (oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as filamin-C (2725 aa, ~291 kDa) is encoded by the human FLNC gene. This protein plays a role in the organization of the cytoskeleton of muscle fibers.", + "output": "ABP-280-Like Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the process that increases the diameter of a blood vessel via the renin-angiotensin system.", + "output": "vasodilation by angiotensin involved in regulation of systemic arterial blood pressure (Molecular Function)" + }, + { + "input": "Definition: something described as a molecular abnormality indicating rearrangement of the IRF4 gene.", + "output": "Multiple Myeloma Oncogene 1 Gene Rearrangement (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a measurement of the growth hormone releasing hormone in a biological specimen.", + "output": "GRWHRH (Laboratory Procedure)" + }, + { + "input": "Definition: RAP1GDS1 gene described as human RAP1GDS1 wild-type allele is located within 4q23-q25 and is approximately 182 kb in length. This allele, which encodes Rap1 GTPase-GDP dissociation stimulator 1 protein, plays a role in the modulation of GTPase activity. A chromosomal translocation t(4;11)(q21;p15) of this gene and the NUP98 gene may be associated with T cell acute lymphocytic leukemia.", + "output": "GDS1 (RAP1GDS1 gene)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 3q", + "output": "3q22-q24 (Chromosome band)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster.", + "output": "female analia morphogenesis (Organism Function)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "regulation of iron ion transport (Cell Function)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.", + "output": "pyrimidine nucleoside binding (nucleoside binding)" + }, + { + "input": "Definition: Paralysis from birth trauma described as a condition characterized by reduced or absent movement of the ipsilateral shoulder, arm or hand as a consequence of an injury to the brachial plexus, cervical roots 5 through 8 and thoracic root 1, sustained during the birthing process.", + "output": "Brachial Plexus Palsy due to Birth Trauma (Paralysis from birth trauma)" + }, + { + "input": "Definition: something described as terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.", + "output": "type II terminal bouton (Cell Component)" + }, + { + "input": "Definition: Malignant neoplasm of gallbladder described as a malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur.", + "output": "GALLBLADDER, CARCINOMA (Neoplastic Process)" + }, + { + "input": "Definition: Polyenes described as a fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.", + "output": "1,6 Diphenylhexatriene (Polyenes)" + }, + { + "input": "Definition: CHAPTER 4 ATTITUDES described as general or specific opinions and beliefs of health-related and other professionals about the person or about other matters (e.g. social, political and economic issues), that influence individual behaviour and actions.", + "output": "Individual attitudes of other professionals (CHAPTER 4 ATTITUDES)" + }, + { + "input": "Definition: Qualitative Concept described as a term used to describe the state or condition of the completeness of the microbiology data.", + "output": "Microbiology Completion Status (Qualitative Concept)" + }, + { + "input": "Definition: Microbiota described as all of the VIRUSES that exist within a particular biological niche such as an organism or specific location of the organism, soil, a body of water, etc.", + "output": "Viral Microbiomes (Virus)" + }, + { + "input": "Definition: Phthalimides described as piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn due to teratogenic effects; it has been reintroduced and used for a number of immunological and inflammatory disorders.", + "output": "Alpha-Phthalimidoglutarimide (Allergen class)" + }, + { + "input": "Definition: something described as presentation of light at intensity levels characteristic of daylight illumination, activating cone photoreceptors in the retina.", + "output": "Photopic Stimulation (Light)" + }, + { + "input": "Definition: CPTAC Questions described as an indication that the edition is other than those listed.", + "output": "Other Edition (CPTAC Questions)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cancer vaccine in which autologous dendritic cells are transfected with patient-specific renal cell carcinoma (RCC) RNA and a synthetic, truncated human CD40 ligand (CD40L) RNA with potential immunostimulatory and antineoplastic activities. Individual RCC-specific RNA, encoding a unique repertoire of tumor-associated antigens (TAAs) (including telomerase reverse transcriptase, G250, and oncofetal antigen) is electroporated into autologous dendritic cells (DCs), transfected with synthetic RNA that encodes a truncated version of the T-cell protein CD40L; the transfected autologous DCs express and process both patient-specific RCC TAAs and the truncated CD40L protein. When reintroduced back to the patient, rocapuldencel-T may elicit a highly specific cytotoxic T-cell (CTL) response against RCC cells expressing the patient-specific RCC TAA repertoire. The signal cascade initiated by stimulation of the truncated, ectopically expressed co-stimulatory molecule CD40L results in the secretion of the inflammatory cytokine IL-12 downstream.", + "output": "Rocapuldencel-T (Immunologic Factor)" + }, + { + "input": "Definition: Food described as an isolate comprised of the sodium or calcium salt of the glycoprotein casein, the primary protein found in milk and other dairy products, with anti-catabolic activity.", + "output": "Caseinate Protein Isolate (Dietary Supplements)" + }, + { + "input": "Definition: Myeloid Progenitor Cells described as a primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes.", + "output": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage (Myeloid Progenitor Cells)" + }, + { + "input": "Definition: protein kinase binding described as interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.", + "output": "mitogen-activated protein kinase kinase kinase binding (protein kinase binding)" + }, + { + "input": "Definition: something described as a finding about one or more characteristics of uveal melanoma, following the rules of the TNM AJCC v8 classification system. This classification system applies to malignant melanoma of the iris, ciliary body, and choroid. Cutaneous melanoma metastatic to the iris, ciliary body, and choroid is staged according to the classification for melanoma of the skin and secondary intraocular extension of conjunctival melanoma is staged according to the classification for conjunctival melanoma.", + "output": "Uveal Melanoma TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying whether, and how, a specific activity in a set of parallel activities should come together before subsequent activities can begin. EXAMPLE(S): Wait for this activity to complete before the subsequent activity; Terminate this activity as soon as all parallel \"wait\" activities are completed (and if this activity hasn't started yet, don't start it at all); Continue this activity after all \"wait\" activities complete, but don't wait for it to complete before beginning subsequent activities. OTHER NAME(S): NOTE(S):", + "output": "Defined Criterion Group Composition Relationship Join Code (Intellectual Product)" + }, + { + "input": "Definition: Bag, device described as containers designed for temporary collection and storage of used disposable products and/or dirty laundry. These containers typically consist of a ventilated basket (e.g., made of wicker or plastic) with a cover; an internal disposable liner (e.g., a plastic bag) to keep the hamper clean and to facilitate storage and manipulation of the hamper contents is usually fixed to the inner surface of the hamper. Hampers are also available as a combination of a hamper stand (a metallic structure) and appropriate hamper bags held by the stand. Large hampers are typically used for temporary storage of soiled laundry until it is moved to a final destination for washing; smaller, portable, typically single-use units are used mainly in isolation procedures and in regular patient rooms for temporary storage of contaminated products (e.g., cloth, bandages), minimizing cross-contamination and odor until their disposal. Some hampers are designed specifically for use in magnetic resonance imaging [MRI] environments, i.e., MRI-compatible hampers, and are made from nonmagnetic materials so that they can be safely used in an MRI suite.", + "output": "Hamper (Manufactured Object)" + }, + { + "input": "Definition: Macrolides described as an orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C37452\" active clinical trials using this agent.", + "output": "Product containing ixabepilone (Epothilone B Analogue)" + }, + { + "input": "Definition: Carcinogens described as saturated, 3-membered organic ring system with 1 nitrogen heteroatom.", + "output": "Azirane (Epichlorohydrin)" + }, + { + "input": "Definition: Genetic Function described as the process in which small interfering RNAs target cognate mRNA molecules for degradation.", + "output": "targeting of mRNA for destruction involved in RNA interference (Genetic Function)" + }, + { + "input": "Definition: Neuroenteric cyst and associated malformation described as the neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium.", + "output": "Cysts, Neuroenteric (Neuroenteric cyst and associated malformation)" + }, + { + "input": "Definition: Finding described as a disorder characterized by a pathologic process involving the brain.", + "output": "Encephalopathy (Nervous System Disorders, CTCAE)" + }, + { + "input": "Definition: Urinary Calculi described as stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.", + "output": "URETER CALCULUS (Urinary Calculi)" + }, + { + "input": "Definition: Virus described as a genus of viruses (family Papovaviridae) containing DNA, having virions about 55 nm in diameter, and including the papilloma and warts viruses of man and other animals, some of which are associated with inductions of carcinoma.", + "output": "Papillomavirus (living organism) [Ambiguous] (Papillomaviridae)" + }, + { + "input": "Definition: Gastrointestinal infection described as intestinal infection with protozoa of the genus Cryptosporidium; occurs in both animals and humans; symptoms include severe diarrhea.", + "output": "Cryptosporidium Infection (protozoal; infection, intestinal)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH.", + "output": "3-oxosphinganine:NADPH oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Gene or Genome described as inactive but stable components of the genome derived from mutations of ancestral genes; probably account for a significant amount of the so-called \"junk DNA\" that comprises most of the genome of eukaryotes.", + "output": "pseudogene (Genome)" + }, + { + "input": "Definition: something described as a question associated with the FACIT-F Version 4 questionnaire.", + "output": "FACIT-F Version 4 Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: Knowledge acquisition described as instruction or programs in school, institutional, or community settings which present material about factors affecting health behavior and attitudes.", + "output": "Advice/education;health (Training and Education)" + }, + { + "input": "Definition: something described as a measurement of leukemia inhibitory factor in a biological specimen.", + "output": "LIF (Laboratory Procedure)" + }, + { + "input": "Definition: Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).", + "output": "Ann Arbor Stage II Mixed Cellularity Classical Hodgkin Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a type of computer tomography whereby a contrast medium is administered intravenously or orally prior to X-ray imaging.", + "output": "dynamic contrast-enhanced computed tomography (X-Ray Computed Tomography)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of a mutated form of the ABL1 gene. In this fusion gene there is a point mutation where thymine has been substituted with cytosine at nucleotide position 949 of the ABL1 gene. This mutation is associated with imatinib- and dasatinib-resistant leukemias.", + "output": "BCR/ABL1 Fusion Gene with ABL1 NM 005157.4:c.949T>C Mutation (Gene or Genome)" + }, + { + "input": "Definition: MPAI-4 Questionnaire Question described as mayo-Portland Adaptability Inventory-4 - Tense, nervous, fearful, phobias, nightmares, flashbacks of stressful events.", + "output": "MPAI-4 - Adjustment: Anxiety (MPAI-4 Questionnaire Question)" + }, + { + "input": "Definition: something described as pertaining to the stomach and intestines.", + "output": "GI (Anatomy Qualifier)" + }, + { + "input": "Definition: Disease or Syndrome described as an extremely rare multiple congenital anomalies/dysmorphic syndrome with characteristics of micrognathia, short webbed neck, hypoplastic nipples and joint contractures (which improve over time) of the knees and elbows. In addition, sloping shoulders, mild to moderate hearing loss, mild speech impairment and facies with hypertelorism, short philtrum and tented upper lip may be associated.", + "output": "Joint contracture, webbed neck, micrognathia, hypoplastic nipple syndrome (Hypoplasia of nipple)" + }, + { + "input": "Definition: something described as a rare lymphoma of the lung defined as a clonal lymphoid proliferation affecting one or both lungs in a patient with no detectable extrapulmonary involvement at diagnosis or during the subsequent 3 months. Comprises low grade/indolent B cell forms, the most frequent form represented by the marginal B-cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) and other non-MALT low grade lymphomas; and more rarely high-grade B-cell and lymphomatoid granulomatosis. Very rare and represents only 3-4% of extranodal non-Hodgkin lymphoma.", + "output": "lymphoma primary pulmonary (Malignant neoplasm of lung)" + }, + { + "input": "Definition: catenin-TCF7L2 complex described as a protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.", + "output": "plakoglobin-TCF4 complex (Cell Component)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time.", + "output": "regulation of transcription from RNA polymerase II promoter involved in heart development (regulation of transcription by RNA polymerase II)" + }, + { + "input": "Definition: Physiological Effects of Drugs described as loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation.", + "output": "Central Stimulants (Psychostimulant)" + }, + { + "input": "Definition: something described as enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid.", + "output": "L-diaminopimelate transmembrane transporter activity (Molecular Function)" + }, + { + "input": "Definition: something described as a clinical variant of Burkitt lymphoma that occurs throughout the world. It affects both children and adults and is more frequently seen in males.", + "output": "Non-endemic Burkitt's lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as the determination of the amount of Vibrio cholerae, Vibrio parahaemolyticus, and/or Vibrio vulnificus DNA present in a sample.", + "output": "C166008 (Microbiology procedure)" + }, + { + "input": "Definition: acetate described as the acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48003\" active clinical trials using this agent.", + "output": "Acetyl-Methylprednisolone (Glucocorticoid inhalants for obstructive airway disease)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the English plantain (Plantago lanceolata) pollen IgE in a biological specimen.", + "output": "C130084 (Immunoglobulin measurement)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure of the amount of ionizing radiation that a subject is exposed to.", + "output": "Unit of Exposure to Ionizing Radiation (Unit of Radiation)" + }, + { + "input": "Definition: something described as reported mortality information for patients.", + "output": "DEATH (Domain)" + }, + { + "input": "Definition: Finding described as an adverse event in a newborn characterized by a perforation in the gastrointestinal tract of a newborn with no demonstrable cause.", + "output": "Neonatal Spontaneous Intestinal Perforation, Adverse Event (Neonatal Adverse Event)" + }, + { + "input": "Definition: Hereditary disorder of musculoskeletal system described as a syndrome consisting of Duane's syndrome, radial ray anomaly, and frequently, HEARING LOSS, SENSORINEURAL.", + "output": "ACRORENOOCULAR SYNDROME (Eye Abnormalities)" + }, + { + "input": "Definition: Organic Chemical described as a 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.", + "output": "1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)- (Chemical categorised functionally)" + }, + { + "input": "Definition: Finding described as HPV-mediated (p16-positive) oropharyngeal cancer with tumor larger than 2 cm but not larger than 4 cm in greatest dimension.", + "output": "HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pT2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Ketone Oxidoreductases described as a ferredoxin-containing enzyme that catalyzes the COENZYME A-dependent oxidative decarboxylation of PYRUVATE to acetyl-COENZYME A and CARBON DIOXIDE.", + "output": "Oxidoreductase, Pyruvate (Ketone Oxidoreductases)" + }, + { + "input": "Definition: License Key described as a non-unique textual key that certifies that the copy of the program is original. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Software.licenseKey (Intellectual Product)" + }, + { + "input": "Definition: Malignant Childhood Central Nervous System Neoplasm described as retinoblastoma during childhood that has not spread beyond the eye.", + "output": "intraocular retinoblastoma (stage, retinoblastoma)" + }, + { + "input": "Definition: Neoplastic Process described as an intraosseous odontogenic neoplasm with good prognosis, arising from the mandible and less frequently from the maxilla. It is characterized by the presence of stellate cells, myxoid stroma formation, and prominent collagen. Small tumors may be cured with enucleation. Complete excision may be required for larger tumors.", + "output": "Odontogenic myxofibroma (Neoplastic Process)" + }, + { + "input": "Definition: Plant described as a plant genus of the family FABACEAE. Members contain piperidine alkaloids (PIPERIDINES).", + "output": "Sesbane (Sesbanieae)" + }, + { + "input": "Definition: something described as the genomic sequence that encodes a ribosomal RNA molecule.", + "output": "Genes, rRNA (Multigene Family)" + }, + { + "input": "Definition: something described as the determination of the amount of free and bound thyroxine present in a sample.", + "output": "Thyroxine (Thyroxine measurement)" + }, + { + "input": "Definition: something described as study Site-specific documentation verifying non-voting members of the Institutional Review Board (IRB) or Independent Ethics Committee (IEC), which is required if the investigator, sub-investigator, or other party with a potential conflict of interest is on the IRB/IEC.", + "output": "IRB-IEC Documentation of Non-Voting Status (Intellectual Product)" + }, + { + "input": "Definition: Domestic mammal described as domestic dog subspecies", + "output": "Canine, NOS (Mammal)" + }, + { + "input": "Definition: Other OR therapeutic procedures; male genital described as a surgical procedure in which an undescended testicle is sutured inside the SCROTUM in male infants or children to correct CRYPTORCHIDISM. Orchiopexy is also performed to treat TESTICULAR TORSION in adults and adolescents.", + "output": "Orchidopexy (Testicular and scrotal therapeutic procedures)" + }, + { + "input": "Definition: Miscellaneous substance administration described as administering an oxidative agent(s) to a client/patient through muscle for therapeutic effect(s) (for example, to restore oxidative balance). Service is billed per treatment.", + "output": "Intramuscular oxidative medicine administration each treatment (Miscellaneous substance administration)" + }, + { + "input": "Definition: Disease or Syndrome described as condition in which there is a deviation or interruption in the processing of proteins in the body: synthesis, absorption, transport, storage, and utilization.", + "output": "Disorder of protein metabolism (Disease or Syndrome)" + }, + { + "input": "Definition: Organism Function described as any process in which a virus stops, prevents, or reduces the activity of MAVS (mitochondrial antiviral signaling protein), a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.", + "output": "inhibition of host MAVS by virus (suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway)" + }, + { + "input": "Definition: something described as a unit of concentration (molarity unit) equal to one millionth of a mole (1E-6 mole) per milligram of a substance per period of time equal to sixty seconds.", + "output": "Micromole per Milligram per Minute (Unit of Dose Calculation)" + }, + { + "input": "Definition: Karnofsky Performance Status described as moribund; fatal processes progressing rapidly.", + "output": "Karnofsky Performance Status 10 (Karnofsky Performance Status)" + }, + { + "input": "Definition: something described as the day of the week an adverse event began.", + "output": "Adverse Event Start Day (Temporal Concept)" + }, + { + "input": "Definition: something described as an oil-resistant synthetic rubber made by the polymerization of chloroprene.", + "output": "Chloroprene Polymers (Elastomers)" + }, + { + "input": "Definition: Finding described as involuntary loss of urine associated with overdistention of the bladder.", + "output": "Overflow incontinence of urine (Urinary Incontinence)" + }, + { + "input": "Definition: Orbital Sarcoma Clinical Distant Metastasis TNM Finding v8 described as orbital sarcoma with distant metastasis.", + "output": "Orbital Sarcoma cM1 TNM Finding v8 (Orbital Sarcoma Clinical Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: therapeutic autologous lymphocytes described as a preparation of autologous T-lymphocytes that have been immunomagnetically depleted of CD14+ myeloid cells and CD25+ regulatory T-cells (Tregs), activated with anti-CD3 and anti-CD28 beads, and transduced with a self-inactivating (SIN) lentiviral vector (LV) encoding a chimeric antigen receptor (CAR) containing a prostate stem cell antigen (PSCA)-specific, humanized and affinity matured A11 single chain variable fragment (scFv), a human immunoglobulin G4 (IgG4) Fc spacer lacking the CH2 domain, a human CD4 transmembrane domain, a costimulatory human 4-1BB (CD137) cytoplasmic signaling domain linked to the zeta chain of the human T-cell receptor (TCR)/CD3 complex (CD3zeta), and a truncated human CD19 sequence (CD19t), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion, the autologous anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes recognize and induce selective toxicity in PSCA-expressing tumor cells. PSCA, a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen, is uniquely and highly expressed in certain cancers including bladder, pancreatic, and prostate cancers. Co-expression of CD19t provides an inert, non-immunogenic surface marker that allows for measurement of genetically modified cells and tracking of T-cells following adoptive transfer. The costimulatory signaling domains improve T-cell function, selectivity, expansion and survival.", + "output": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-cells (Chimeric Antigen Receptor T-cells)" + }, + { + "input": "Definition: something described as physical location of FGF7_Gene", + "output": "15: 47502751-47566815 (Spatial Concept)" + }, + { + "input": "Definition: Bispecific Monoclonal Antibodies described as a bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) FLT3 tyrosine kinase receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-FLT3/CD3 BiTE antibody AMG 427, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and FLT3 found on FLT3-expressing tumor cells. This activates and redirects CTLs to FLT3-expressing tumor cells, which results in the CTL-mediated cell death of FLT3-expressing tumor cells. FLT3, a cytokine receptor belonging to the class III tyrosine kinase receptors, is overexpressed or mutated in most B-lineage and acute myeloid leukemias (AMLs).", + "output": "AMG427 (Flt-3-targeting Agent)" + }, + { + "input": "Definition: Gut described as portion of the digestive canal between the pharynx and stomach.", + "output": "Gastrointestinal Tract, Esophagus (esophagus and stomach)" + }, + { + "input": "Definition: assessment of facies described as this is a description previously used to describe a facial form characterized by a short, upturned nose, wide mouth, widely spaced eyes, and full cheeks. Because of the imprecision in this definition it is preferable to describe these features precisely. This term is retained because it was often used in the past, but it should not be used for new annotations.", + "output": "Elf-like facial appearance (assessment of facies)" + }, + { + "input": "Definition: something described as a standardized 36-item self-report rating scale to measure quality of life in patients with colorectal cancer that is divided into five subscales: physical, social/family, emotional, and functional well-being, as well as a colorectal cancer specific subscale. Originally developed by Cella, et al. in 1997, it combines the Functional Assessment of Cancer Therapy - General (FACT-G), and the Colorectal Cancer Subscale (CCS).", + "output": "FACT-C V4 (Intellectual Product)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to stand upright.", + "output": "Ability to Stand Upright (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cell described as a cell derived from a myeloid progenitor cell. It differentiates into a promonocyte. It is about 12 to 20 micrometer in diameter, has a round to oval nucleus with fine, lightly dispersed chromatin and one to four nucleoli. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone. Monoblasts are found in bone marrow and never appear in the normal peripheral blood.", + "output": "Marrow monoblast (Monocytes)" + }, + { + "input": "Definition: Pharmacologic Substance described as any of a class of alkylating agents that contain both a nitroso group and a urea. They are lipophilic and can cross the blood-brain barrier.", + "output": "nitrosoureas (Pharmacologic Substance)" + }, + { + "input": "Definition: OAB-q Short Form Questionnaire Question described as the Overactive Bladder Questionnaire Short Form (OAB-q Short Form) Nighttime urination?", + "output": "OABQ0204 (OAB-q Short Form Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62530\" active clinical trials using this agent.", + "output": "varlitinib (Epidermal growth factor receptor inhibitor)" + }, + { + "input": "Definition: something described as a central nervous system embryonal tumor, not otherwise specified arising from the spinal cord.", + "output": "Spinal Cord PNET (Malignant neoplasm of spinal cord)" + }, + { + "input": "Definition: positive regulation of mRNA splicing, via spliceosome described as any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome.", + "output": "positive regulation of mRNA cis splicing, via spliceosome (positive regulation of mRNA splicing, via spliceosome)" + }, + { + "input": "Definition: Finding described as cutaneous melanoma with no detectable evidence of distant metastases.", + "output": "Cutaneous Melanoma cM0 TNM Finding v7 (Cutaneous Melanoma Clinical Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: something described as long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.", + "output": "SULFALENE (Organic Chemical)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol.", + "output": "ent-kaurene oxidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as asthma Nighttime Symptom Diary V1.0 (ANSD Version 1.0) Total score.", + "output": "ANSD01-Total Score (Intellectual Product)" + }, + { + "input": "Definition: something described as PQCMC data submitted to a biologics license application.", + "output": "Biologics License Application (Application to Market New Drug, Biologic, or Antibiotic for Human Use)" + }, + { + "input": "Definition: Intellectual Product described as auditory Verbal Learning Test Version A - List B, Word 9.", + "output": "AVL01-List B Recall Word 9 (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a rare variant of carcinoma of the urachal remnant of bladder.", + "output": "Bladder Urachal Cancer (Carcinoma of bladder)" + }, + { + "input": "Definition: Medical Device described as containers designed to provide a cold environment to blood and/or blood products during transportation using frozen water (also known as wet ice) as a refrigerant. These containers typically consist of a polystyrene container, including polystyrene dividers covered by an outer cardboard shell (also known as a Collins box) with capacity enough (typically about 3 cubic feet/85 cubic dm for 18 units of whole blood) for the ice and the blood bags. Wet-ice blood transport containers are used for keeping maintaining blood viability for a period of time of about 48 hours during transportation of products between healthcare facilities or to remote places during emergency situations, combat, or other needs; the containers are also available in other sizes, they may be portable or mobile.", + "output": "Wet Ice Transport Containers, Blood/Blood Product (Transport Containers, Thermal Protection, Wet Ice)" + }, + { + "input": "Definition: negative regulation of mRNA catabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.", + "output": "down-regulation of mRNA breakdown, deadenylation-dependent decay (negative regulation of mRNA catabolic process)" + }, + { + "input": "Definition: LABORATORY IMMUNOLOGIC PROCEDURES described as a cytologic technique for measuring the functional capacity of stem cells by assaying their activity.", + "output": "CFU assay (Cell function assay)" + }, + { + "input": "Definition: Drug allergens described as 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.", + "output": "aneurin (Nitrogen and nitrogen compound)" + }, + { + "input": "Definition: something described as an anomalous amount of protein present in or on the surface of muscle fibers. This feature may be appreciate upon immunohistochemical investigation of muscle biopsy tissue. []", + "output": "Abnormal muscle fiber protein expression (Abnormal muscle fiber morphology)" + }, + { + "input": "Definition: something described as sedimentation field is either gravitational or centrifugal.", + "output": "SdFFF (Laboratory Procedure)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the Zic family member 2 (ZIC2) gene, located at chromosome 13q32, which encodes for a protein that functions as a transcriptional repressor and may regulate tissue-specific expression of the dopamine receptor D1. This inherited genetic mutation has been identified in patients with early-onset holoprosencephaly-5.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ZIC2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Finding described as an electrocardiographic finding of the Q axis from +90 to +180 degrees.", + "output": "Q AXIS, RIGHT AXIS DEVIATION (Finding)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A.", + "output": "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis.", + "output": "Ingenol Mebutate (I [Preparations])" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify CTG repeats in the junctophilin 3 (JPH3) gene, located at chromosome 16q24.3. Normal alleles have from 6 to 28 CAG/CTG trinucleotide repeats. A variation from the expected number of normal CAG/CTG trinucleotide repeat copies may produce altered DNA and improper gene functioning, resulting in full mutation. Alleles with from 44 to 59 CAG/CTG trinucleotide repeats have been associated with Huntingdon's disease type 2 (HDL2); however, individuals with from 29 to 43 CAG/CTG repeats may not develop symptoms.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CTG, JPH3 Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CTG)" + }, + { + "input": "Definition: Abnormal palate morphology described as a fistula which connects the oral cavity and the pharyngeal area via the aspects of the soft palate.", + "output": "fistula of palate (mucosal findings of palate)" + }, + { + "input": "Definition: Temporal Concept described as the time data creation began.", + "output": "Content Time (Time)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's observation of the worst severity they have experienced related to breast area enlargement or tenderness in the past seven days.", + "output": "In the last 7 days, what was the SEVERITY of your BREAST AREA ENLARGEMENT OR TENDERNESS at its WORST (Findings-Based Question)" + }, + { + "input": "Definition: Biochemical Pathway described as an elaboration of the known steps and interactions for the metabolism of a compound.", + "output": "Metabolism (Biochemical Pathway)" + }, + { + "input": "Definition: Neoplastic Process described as an infiltrating astrocytic tumor of the brain occurring in adults.", + "output": "Adult Infiltrating Astrocytic Tumor (Adult Astrocytic Tumor)" + }, + { + "input": "Definition: something described as a malignant neoplasm arising from squamous epithelial cells.", + "output": "Squamous cell carcinoma NOS (Papillary and Squamous Cell Neoplasms)" + }, + { + "input": "Definition: something described as perihilar bile duct cancer with distant metastasis.", + "output": "Perihilar Bile Duct Cancer pM1 TNM Finding v7 (Perihilar Bile Duct Cancer Pathologic Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: Stationary Digital Tomosynthesis described as stationary digital tomography used to image structures in the thoracic cavity.", + "output": "s-DCT (Diagnostic Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as talofibular ligament, each instance of which is a fibrous band that pass from the anterior part of the lateral malleolus of some fibula to the anterior margin of the lateral articular part of some talus.", + "output": "anterior ligaments talofibular (Ligaments)" + }, + { + "input": "Definition: Social Circumstances - Other, Specify, CTCAE described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Social Circumstances - Other, Specify, CTCAE (Finding)" + }, + { + "input": "Definition: something described as a private institution charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive. This process, called Conformity Assessment, has EU-wide validity once completed by the NB.", + "output": "NB (Organization)" + }, + { + "input": "Definition: EYES AND EYE APPENDAGES described as a gland in the margins of the eyelids that opens into the follicles of the eyelashes and produces secretions that lubricate the eyeball.", + "output": "Eyelid, sweat gland (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Homeopathic remedies letter A described as alkaloid of morphine.", + "output": "Apomorphinum / morphine alkaloid (Pharmacologic Substance)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque +/- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque +/- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary) cells but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88162\" active clinical trials using this agent.", + "output": "Stage IVB Mycosis Fungoides and S\u00e9zary Syndrome (Mycosis fungoides/Sezary syndrome stage IV)" + }, + { + "input": "Definition: Finding of palmar crease described as the distal and proximal transverse palmar creases are merged into a single transverse palmar crease.", + "output": "Single palmar creases (Finding of palmar crease)" + }, + { + "input": "Definition: Biochemistry described as a discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.", + "output": "DNA Molecular Biology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Ureteric cancer regional described as a carcinoma of the ureter that has not spread to other regions.", + "output": "Regional Malignant Ureteral Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Other Embryologic Structure described as the development of the kidney after the eleventh week of gestation until the time of birth.", + "output": "Fetal Kidney (Embryonic Structure)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) Description of active suicidal ideation with any methods (not plan) without intent to act.", + "output": "C-SSRS Screening - Description of Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (Intellectual Product)" + }, + { + "input": "Definition: something described as separation of chromosomes during cell division.", + "output": "chromosome movement (Genetic Function)" + }, + { + "input": "Definition: Red cell membrane and enzyme abnormalities described as hemolytic anemia for which the cause is an inherited disorder.", + "output": "Hemolytic Anemias, Hereditary (Perinatal anemia)" + }, + { + "input": "Definition: Cytochrome b Group described as cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.", + "output": "Cytochrome b5 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: infection due to arbovirus with fever, malaise, and hemorrhagic signs described as an acute infection caused by a mosquito-borne alphavirus CHIKUNGUNYA VIRUS characterized by RASH; FEVER; JOINT PAINS; CONJUNCTIVITIS; MENINGOENCEPHALITIS; LYMPHOPENIA; and THROMBOCYTOPENIA.", + "output": "Chikungunya (hemorrhagic) fever (infection due to arbovirus with fever, malaise, and hemorrhagic signs)" + }, + { + "input": "Definition: Zone of petrous part of temporal bone described as zone of petrous part of temporal bone, each instance of which is a thin lamella of bone that divides some musculotubal canal into semicanals for some tensor tympani muslce and some auditory tube.", + "output": "Septum of musculotubal canal (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Homeopathic remedies letter C described as salicylate of quinine.", + "output": "China salicylicum / quinine salicylate (Homeopathic remedies letter C)" + }, + { + "input": "Definition: something described as a sequence of digits or characters used to identify a particular telephone, fax, or email of the insured person. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Insured Person Telecom Address (Intellectual Product)" + }, + { + "input": "Definition: DNA-templated transcription, initiation described as any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.", + "output": "transcription initiation from RNA polymerase II promoter (Genetic Function)" + }, + { + "input": "Definition: Sp\u00e1nkov\u00e9 poruchy NEC in MDRCZE23 0 described as the state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.", + "output": "rndx sleep deprivation (Encounter due to problems related to sleep)" + }, + { + "input": "Definition: Language described as an Afro-Asiatic language spoken by the Bilen people in Eritrea and eastern Sudan.", + "output": "Bilin (Language)" + }, + { + "input": "Definition: Small Intestinal Carcinoid Tumor described as a well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the duodenum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.", + "output": "Carcinoid Tumor of the Duodenum (Gastrointestinal neoplasms NEC)" + }, + { + "input": "Definition: cell wall organization described as a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall.", + "output": "cellulose and pectin-containing cell wall organization and biogenesis (Cell Function)" + }, + { + "input": "Definition: Medical Devices described as the type of absorbent material in an X-ray filter.", + "output": "X-Ray Filter Material (Manufactured Object)" + }, + { + "input": "Definition: something described as a descendent of Collie type dogs, this herding dog was bred to withstand harsh heat and dry conditions of Australia. This dog is loyal, alert, and intelligent. The coat is either long-hair or smooth-hair and either black, tan or liver brown. The average height range is 17-20 inches and the average weight range is 13-20 pounds.", + "output": "Australian Kelpie (Mammal)" + }, + { + "input": "Definition: something described as a vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo.", + "output": "KHELLIN (Psoralens)" + }, + { + "input": "Definition: Chromosomes described as the designation for each member of the tenth largest human autosomal chromosome pair. Chromosome 10 spans about 135 million base pairs and represents between 4 and 4.5% of the total DNA in normal diploid cells.", + "output": "10 chromosome (Chromosomes, Human)" + }, + { + "input": "Definition: Philosophy, Medical described as an ancient Greek medical theory that health and illness result from a balance or imbalance of body fluids or \"humors\". The humors are blood, phlegm, yellow bile, and black bile.", + "output": "Humoralism (Idea or Concept)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.", + "output": "positive regulation of transcription by transcription factor localization (cellular protein localization)" + }, + { + "input": "Definition: Numeric Test Result described as the numerical identifier of microscopic findings result in standard units.", + "output": "MISTRESN (Numeric Test Result)" + }, + { + "input": "Definition: Oils, Volatile described as sweet marjoram.", + "output": "origanum marjorana (Plant)" + }, + { + "input": "Definition: Ventilation cycle time described as the recorded time interval between the initiation of inhalation and the point at which no further lung volume expansion occurs.", + "output": "TI - Inspiratory time (Pulmonary function tests)" + }, + { + "input": "Definition: Disease or Syndrome described as narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication. []", + "output": "Peripheral arterial stenosis (Disease of non-coronary systemic artery)" + }, + { + "input": "Definition: something described as a properdin factor B immunological test system is a device that consists of the reagents used to measure by immunochemical techniques properdin factor B in serum and other body fluids. The deposition of properdin factor B in body tissues or a corresponding depression in the amount of properdin factor B in serum and other body fluids is evidence of the involvement of the alternative to the classical pathway of activation of complement (a group of plasma proteins which cause the destruction of cells which are foreign to the body). Measurement of properdin factor B aids in the diagnosis of several kidney diseases, e.g., chronic glomerulonephritis (inflammation of the glomeruli of the kidney), lupus nephritis (kidney disease associated with a multisystem autoimmune disease, systemic lupus erythematosus), as well as several skin diseases, e.g., dermititis herpetiformis (presence of vesicles on the skin that burn and itch), and pemphigus vulgaris (large vesicles on the skin). Other diseases in which the alternate pathway of complement activation has been implicated include rheumatoid arthritis, sickle cell anemia, and gram-negative bacteremia.", + "output": "FACTOR B, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Electromagnetic Radiation described as penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.", + "output": "grenz ray (Radiation)" + }, + { + "input": "Definition: regulation of arginase activity described as any process that activates or increases the frequency, rate or extent of arginase activity.", + "output": "positive regulation of arginase activity (Molecular Function)" + }, + { + "input": "Definition: Silurana described as the Western clawed frog, Xenopus tropicalis.", + "output": "Xenopus laevis tropicalis (Amphibian)" + }, + { + "input": "Definition: secondary metabolite catabolic process described as the chemical reactions and pathways resulting in the breakdown of violaceol II.", + "output": "violaceol II catabolic process (mycotoxin catabolic process)" + }, + { + "input": "Definition: something described as psoriasis Area and Severity Index - Lower Extremities (L): Sum x area x 0.4.", + "output": "PASI01-Low Extrem (L): Sum X Area X 0.4 (Intellectual Product)" + }, + { + "input": "Definition: Pituitary Agent described as a highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.", + "output": "Thyrotropin alfa product (Hypothalamic Releasing Factor)" + }, + { + "input": "Definition: Finding described as an artifact that occurs when tissues in another plane get added to the image.", + "output": "Out of Plane Wrap Around Artifact (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in cellular proliferation and motility.", + "output": "immunoglobulin superfamily member 8 (Gene or Genome)" + }, + { + "input": "Definition: something described as impaired or altered function of the ligament.", + "output": "Ligament Somatic Dysfunction (Somatic dysfunction)" + }, + { + "input": "Definition: Longitudinal deficiency of limb described as congenital polychondrodystrophy in which narrow and rigid thoracic cage results in asphyxia, ranging in severity from mild cases with minimal respiratory symptoms to fatal asphyxiation. Skeletal dysplasia is not limited to the thoracic structures and may also involve other organs. The affected infants exhibit short-limb dwarfism, ribs, small thoracic cage, and irregular epiphyses and metaphyses. A variety of other abnormalities may be occur, including intestinal malabsorption, renal and hepatic changes, eye abnormalities, hydrocephalus, and infrequent mental retardation. Some cases exhibit ectodermal dysplasia manifestations, such as sparse hair, faulty dentition, and hypoplastic skin over the hands. The syndrome represents a spectrum of disorders with a wide variability in clinical and radiological manifestations.", + "output": "jeune syndrome (Dwarfism)" + }, + { + "input": "Definition: INTELLIGENCE AND LEVELS OF INTELLIGENCE described as the ability to learn and to deal with new situations and to deal effectively with tasks involving abstractions.", + "output": "INTELLIGENCE (Cognitive functions)" + }, + { + "input": "Definition: Neoplastic Process described as a hemangioma arising from the heart.", + "output": "Cardiac hemangioma (Visceral hemangioma)" + }, + { + "input": "Definition: Anatomical Abnormality described as interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity.", + "output": "Stiff hinge joints (Anatomical Abnormality)" + }, + { + "input": "Definition: Neoplastic Process described as a liposarcoma involving the colon.", + "output": "Colon Liposarcoma (Colon Sarcoma)" + }, + { + "input": "Definition: Finding described as a deviation from the normal concentration of hyaluronic acid in the blood.", + "output": "Abnormal circulating hyaluronic acid concentration (Finding)" + }, + { + "input": "Definition: Cell described as allogeneic, off-the-shelf, universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these cells target and bind to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology, the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby abrogating the potential induction of graft-versus-host disease (GvHD) by the donor T-cells.", + "output": "allogeneic engineered T cells expressing anti-CD123 chimeric antigen receptor (Chimeric Antigen Receptor T-cells)" + }, + { + "input": "Definition: deacetylase activity described as catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol.", + "output": "steryl deacetylase activity (Molecular Function)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+.", + "output": "brassicasterol glucosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: Medical Device described as vascular surgical clips designed for the temporary atraumatic occlusion of blood vessel aneurysms during surgical procedures. These clips are typically small, usually metal (e.g., cobalt, titanium alloy) instruments with two blades joined at the midportion or made from a single alpha-shaped part. Aneurysm surgical clips are usually applied manually; they do not include a handle or other proximal attachment for manipulation. Aneurysm clips are used mainly for hemostasis and/or to facilitate surgical procedures by temporarily interrupting of blood circulation into a vessel aneurysm.", + "output": "Clips, Surgical, Vascular, Aneurysm (Clips, Surgical, Vascular)" + }, + { + "input": "Definition: health-related beliefs described as personal convictions that influence health behaviors", + "output": "belief health (Finding)" + }, + { + "input": "Definition: TET3 gene described as human TET3 wild-type allele is located in the vicinity of 2p13.1 and is approximately 125 kb in length. This allele, which encodes methylcytosine dioxygenase TET3 protein, is involved in DNA demethylation.", + "output": "MGC22014 (Gene or Genome)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake.", + "output": "cellular response to caloric restriction (Cellular Stress Response)" + }, + { + "input": "Definition: something described as an estriol test system is a device intended to measure estriol, an estrogenic steroid, in plasma, serum, and urine of pregnant females. Estriol measurements are used in the diagnosis and treatment of fetoplacental distress in certain cases of high-risk pregnancy.", + "output": "RADIOIMMUNOASSAY, ESTRIOL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Organic Chemical described as d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.", + "output": "d-methorphan (Adjuvant Analgesic)" + }, + { + "input": "Definition: something described as the cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.", + "output": "neuron maintenance (cellular homeostasis)" + }, + { + "input": "Definition: General biomedical implant described as artificial substitute for a missing body part or function; used for functional or cosmetic reasons, or both.", + "output": "prosthesis (Medical & Physical Treatment)" + }, + { + "input": "Definition: Social Behavior described as the act of following a medical regimen or schedule correctly and consistently, including taking medicines or following a diet.", + "output": "Client Compliances (Social Behavior)" + }, + { + "input": "Definition: Degenerative brain disorder described as a rare genetic neurodegenerative disease characterised by movement disorders, including dystonia, chorea, myoclonus, tremor and rigidity. Associated features are also cognitive and memory impairment, early psychiatric disturbances and behavioural problems.", + "output": "Huntington disease-like syndrome due to C9ORF72 expansions (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: something described as any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation.", + "output": "stimulatory killer cell immunoglobulin-like receptor signalling pathway (Molecular Function)" + }, + { + "input": "Definition: sulfur compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of succinyl-CoA.", + "output": "succinyl-CoA catabolism (ribonucleoside bisphosphate catabolic process)" + }, + { + "input": "Definition: something described as magnets designed to be used with nuclear magnetic resonance (NMR) spectroscopy systems. NMR magnets are typically superconducting magnets capable of generating magnetic field strengths between 5 and 23 Tesla, which corresponds to proton NMR frequencies between 200 and 1,000 MHz. In order to function as superconductors, the wires of the electromagnet must be cooled to near absolute zero, and NMR magnets typically include multiple reservoirs (i.e., dewars) for cyrogens (e.g., liquid helium), which serve to cool the magnet wires. High-strength magnets may also incorporate shielding to limit the size of the area affected by the generated magnetic field.", + "output": "NMR Magnets (Electromechanical Devices)" + }, + { + "input": "Definition: something described as an oral suspension containing the thiopurine-derivative antimetabolite 6-mercaptopurine, with potential antineoplastic activity. Upon oral administration, mercaptopurine is metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions and de novo purine ribonucleotide synthesis, which both blocks the formation of purine nucleotides and inhibits DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. By blocking DNA synthesis and replication, cancer cells are unable to proliferate. Compared to the tablet formulation, the liquid is easier to swallow and offers more flexibility and accuracy in dosing, which is beneficial for use in pediatric patients. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C111757\" active clinical trials using this agent.", + "output": "Mercaptopurine Oral Suspension (Purine antagonist)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone.", + "output": "9-fluorenone-3,4-dioxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Immunologic Factor described as a cancer priming vaccine consisting of tumor-specific shared neoantigens, which are immunogenic and unique across a subset of patients, with potential immunostimulating and antineoplastic activities. Upon administration of neoantigen-based therapeutic cancer vaccine GRT-C903, followed by the boosting vaccine GRT-R904, the peptides stimulate the host immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against the shared neoantigens expressed on tumor cells, which results in tumor cell lysis.", + "output": "GRTC903 (Immunologic Factor)" + }, + { + "input": "Definition: something described as this gene plays a role in protein binding.", + "output": "GPC6 Gene (Gene or Genome)" + }, + { + "input": "Definition: Eye described as underdevelopment of the lacrimal gland.", + "output": "Underdeveloped tear gland (Aplastic/hypoplastic lacrimal glands)" + }, + { + "input": "Definition: Reverse-osmosis water purification system described as reverse osmosis (RO) water purification systems designed to deliver water pure enough for hemodialysis procedures. These systems typically consist of a container with a central semi-permeable membrane separating the contaminated water from the purified water. Hydrostatic pressure high enough to exceed the osmotic pressure is then applied to the contaminated water section. The membrane is permeable to water but impermeable to the solutes thus providing purified water on the other side of the membrane. RO systems used in hemodialysis remove salts, metal ions, and particulates to a greater degree than standard RO systems. Water obtained after the procedure should be tested periodically due to the high volume of water that patients are exposed to during hemodialysis in which even trace quantities of contaminants (e.g., aluminum) may be dangerous. The elimination of chloramines (e.g., using a carbon bed) present in tap water is also essential. Hemodialysis reverse osmosis is usually performed after filtration to eliminate particulates from the incoming water. Deionization, ultrafiltration, and/or disinfection with ultraviolet radiation may be needed after reverse osmosis if the presence of contaminants is high due to the fact that RO removes percentages (e.g., 95 to 99 percent) rather than fixed quantities of contaminants. Portable hemodialysis RO systems are also available.", + "output": "reverse osmosis water purification system for hemodialysis (Reverse-osmosis water purification system)" + }, + { + "input": "Definition: something described as catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.", + "output": "sphingosine-1-phosphate aldolase activity (Molecular Function)" + }, + { + "input": "Definition: Research Device described as based upon the natural F plasmid of E. coli. Inserts up to 300 Kb can be cloned and stably maintained as circular molecules.", + "output": "Chromosomes, Bacterial Artificial (Chromosomes, Bacterial)" + }, + { + "input": "Definition: Allergy testing described as analyzing a client/patient's blood, hair, urine and/or other sample to assess his or her allergic response(s) to up to 212 antigens including 112 food, 30 environmental, 28 mold, 28 additive and 14 food coloring antigens using an ELISA/ACT(R) Screening Combination Block B. Service is billed per test.", + "output": "E/A S.C.B.B ea.tst (Laboratory Procedure)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "pyrimidine nucleoside transport (nucleoside transport)" + }, + { + "input": "Definition: Identifier described as a unique symbol that establishes identity of the qualified person. EXAMPLE(S): The identifier assigned in the NCI investigator registry (National Cancer Institute Principal Investigator Identifier Number) to a physician approved for conducting a clinical trial.", + "output": "QualifiedPerson.identifier (Identifier)" + }, + { + "input": "Definition: Hemorheology described as rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.", + "output": "pulsatile flow (Phenomenon or Process)" + }, + { + "input": "Definition: something described as dispensers designed to store and deliver food service dishes, such as plate and bowls. These dispensers usually consist of an enclosure made of metal, plastic, or a combination of these, with an opening to deliver the dishes. Some food service plate dispensers also have the ability to warm the dishes. Some food service dish dispensers are adjustable to accommodate different sizes of plates, bowls, and other dishes. These units can be stand alone and mobile or stationary. They may also be drop-in units that are placed in a food service cabinet or table.", + "output": "Food Plate Dispensers (Dispenser)" + }, + { + "input": "Definition: Anatomical Abnormality described as a secondary ossification center in the distal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.", + "output": "Pseudoepiphysis of the distal phalanx of the 2nd finger (Abnormality of the epiphysis of the distal phalanx of the 2nd finger)" + }, + { + "input": "Definition: Medical Device described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray.", + "output": "SOLUTION-TEST STANDARD-CONDUCTIVITY, DIALYSIS (Medical Device)" + }, + { + "input": "Definition: enone reductase activity described as catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+).", + "output": "(+)-cis-isopulegone:NADP+ oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Autologous Tumor Cell Vaccine described as an autologous tumor cell vaccine containing irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Autologous breast cancer cells are transduced ex vivo with an adenovirus vector encoding the GM-CSF gene and irradiated and then reintroduced into the patient. Upon repeated subcutaneous administration of the vaccine, autologous GM-CSF-secreting breast cancer cells secrete GM-CSF, which may stimulate a tumor-specific cytotoxic T-lymphocyte (CTL) response.", + "output": "Autologous GM-CSF-Secreting Breast Cancer Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: TSCYC Questionnaire Question described as trauma Symptom Checklist for Young Children - Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Hitting adults (including parents).", + "output": "TSCYC - Hitting Adults (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: Pharmaceutical Adjuvants described as a carbohydrate polymer composed of mannose and galactose, with chemotherapeutic enhancing activity. Galactomannan derivative binds to galectins on cell surfaces and may promote the transport of certain chemotherapeutics, such as 5-fluorouracil (5-FU), into tumor cells. This may increase the antineoplastic effect of 5-FU when administered concomitantly. Galectins are carbohydrate-binding proteins, upregulated on the surface of certain types of tumor cells, and may mediate cell association, survival and metastasis.", + "output": "Galactomannan Derivative (Pharmaceutical Adjuvants)" + }, + { + "input": "Definition: something described as high-pressure packed-column liquid chromatography systems in which the packing of the column is made of microparticulate silica gel. The functional groups of the stationary phase may be polar relative to those of the mobile phase (i.e., normal bonded-phase chromatography) or, more usually, nonpolar (i.e., reverse bonded-phase chromatography).", + "output": "Chromatography Systems, Liquid, Packed Column, High-Pressure, Bonded-Phase (Chromatography Systems, Liquid, Packed Column, High-Pressure)" + }, + { + "input": "Definition: something described as a form of diazoxide-sensitive diffuse hyperinsulinism caused by a lowered threshold for insulin release. Characterised by excessive/uncontrolled insulin secretion and recurrent episodes of profound hypoglycaemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent neurological sequelae. Activating mutations of GCK (7p15.3-p15.1) that encodes glucokinase have been identified as the cause.", + "output": "Hyperinsulinism due to deficiency of glucokinase (Hyperinsulinism)" + }, + { + "input": "Definition: Refractory Head and Neck Squamous Cell Carcinoma described as oral cavity squamous cell carcinoma that does not respond to treatment.", + "output": "Refractory Oral Cavity Squamous Cell Cancer (Refractory Head and Neck Squamous Cell Carcinoma)" + }, + { + "input": "Definition: Therapeutic procedure described as a procedure that is done to treat a nervous system disorder.", + "output": "Therapeutic Nervous System Procedures (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Bacterium described as a species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotile, non-spore forming, beta-N-acetyl-glucosaminidase positive, indole, catalase, lipase, alpha-fucosidase, and trypsin negative, pigmented, weakly saccharolytic, and does not reduce nitrate or hydrolyze starch or esculin. P. somerae is associated with chronic foot infections in individuals with diabetes or vascular disease.", + "output": "Porphyromonas somerae Summanen et al. 2006 emend. Hahnke et al. 2016 (Porphyromonas)" + }, + { + "input": "Definition: Structure of thorax, including mediastinum and diaphragm described as the region of the thorax that includes the PLEURAL CAVITY and MEDIASTINUM.", + "output": "chest cavity (Body part)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).", + "output": "ATP-L-glutamate 5-phosphotransferase activity (phosphotransferase activity, carboxyl group as acceptor)" + }, + { + "input": "Definition: something described as deployment Risk and Resilience Inventory-2 (DRRI-2) Either in preparation for or during my deployment: I took preventative pills (for example, to protect against nerve gas).", + "output": "DRRI1F01 (Intellectual Product)" + }, + { + "input": "Definition: Study Day described as the day that a microscopic findings assessment is performed.", + "output": "MIDY (Temporal Concept)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as terminology relevant to the state or condition of the microbe or lesion to indicate whether it is resistant to drugs normally used in treatment.", + "output": "CDISC SDTM Drug Resistance Status Terminology (CDISC SDTM Terminology)" + }, + { + "input": "Definition: something described as a sodium-dependent phosphate transporter present primarily at apical sites of EPITHELIAL CELLS in the SMALL INTESTINE.", + "output": "Type IIb Sodium-Phosphate Symporter Proteins (Sodium-Phosphate Cotransporter Proteins, Type II)" + }, + { + "input": "Definition: Antibody Therapy described as radiation therapy using radiolabelled antibodies", + "output": "Immunotherapy, Cancer, Radioisotope (Antibody Therapy)" + }, + { + "input": "Definition: cellular diagnosis, childhood rhabdomyosarcoma described as a morphological variant of alveolar rhabdomyosarcoma that occurs in children. The neoplasm is composed of alveolar and embryonic components. It is characterized by the presence of spindle cells with myoblastic differentiation and a myxoid and a fibrous stroma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7960\" active clinical trials using this agent.", + "output": "Mixed Childhood Rhabdomyosarcoma (Rhabdomyosarcoma with Mixed Embryonal and Alveolar Features)" + }, + { + "input": "Definition: Class Ascomycetes described as a species of yeast in the genus Candida.", + "output": "Candida parapsilosis var obtusa (Candida sp)" + }, + { + "input": "Definition: Immunoaffinity Chromatography described as a cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow of patients who are to undergo autologous bone marrow transplantation.", + "output": "Magnetic Bead Separation (Immunoaffinity Chromatography)" + }, + { + "input": "Definition: Healthcare facility device and adaptation described as mounts designed to hold television sets in place. These mounts typically consist of supports, backings, settings, clamps, and accessories that permit the attachment of television sets to structures or furniture (e.g., walls, beds, ceilings).", + "output": "Television Set Mounts (Healthcare facility device and adaptation)" + }, + { + "input": "Definition: Retinal Vein Occlusion described as blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels.", + "output": "Branch retinal vein occlusion (Venoocclusive disease)" + }, + { + "input": "Definition: regulation of centrosome cycle described as any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.", + "output": "regulation of centrosome duplication (regulation of centrosome cycle)" + }, + { + "input": "Definition: LIM Domain Proteins described as paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.", + "output": "paxillin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Mental Process described as mental functions that permit refocusing concentration from one stimulus to another.", + "output": "Shifting attention (Attention)" + }, + { + "input": "Definition: Complement Measurement described as a measurement of the complement C4a in a biological specimen.", + "output": "Complement C4a measurement (LABORATORY IMMUNOLOGIC PROCEDURES)" + }, + { + "input": "Definition: Haemorrhages NEC described as small areas of bleeding (hemorrhage) under the fingernail or toenail.", + "output": "Nail bed bleeding (Nail and nail bed conditions)" + }, + { + "input": "Definition: Medical Device described as cooling units designed to lower a patient's body temperature by circulating liquid through hoses in close contact with the outside of the patient's body. These units consist of a central refrigerator system which pumps cooled liquid through hoses to other hoses contained inside a device in contact with the patient's body (e.g., a pad, mattress, or blanket, or a head wrap or vest worn by a patient); most also feature temperature controls and alarms. Patient temperature is typically monitored with a thermometer. Circulating-liquid patient cooling units are used for cooling patients with fever or to induce hypothermia in the operating room. They may also be used to induce temporary hypothermia, in order to limit tissue damage in patients who have suffered a stroke or other cardiovascular or neurological event.", + "output": "Patient Cooling Units, Circulating Liquid (Cooling Units, Patient)" + }, + { + "input": "Definition: Biomedical or Dental Material described as medicinal product consisting of a powder and solvent for solution for injection presented in a pre-filled pen. The powder and solvent are contained in different compartments of the pre-filled pen, which contains all of the components necessary to prepare the solution for injection.", + "output": "Powder and Solvent for Solution for Injection in Pre-filled Pen (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as region in which a stationary electric charge experiences a force due to its charge.", + "output": "Electric field (Electric potential)" + }, + { + "input": "Definition: Samplers, Environmental, Air described as air samplers designed to obtain samples of biological agents that are present in the air, usually in the form of aerosol particles. These devices can capture small (e.g., from 2 to 10 microns) aerosol particles of biopathogens such as bacteria, viruses, fungi, and toxins for laboratory analysis. The samplers typically include blowers, which provide a high airflow rate and permit rapid biological sample collection in a short period (e.g., a few minutes), either in indoor or outdoor environments. Both dry systems that use special filters and wet systems that collect the samples in a liquid medium are available; some wet-system samplers include pumps for sample transfer to the detectors. Biological agent samplers are intended to monitor for infectious diseases in clinical wards, workplaces (e.g., mail rooms), and airports; they can also be used to detect biological pathogens in agricultural products and livestock.", + "output": "Samplers, Environmental, Air, Biological Agent (Samplers, Environmental, Air)" + }, + { + "input": "Definition: something described as a subjective score of 7 on a fatigue scale that ranges from 0: No Fatigue to 10: Fatigue as bad as you can imagine.", + "output": "Fatigue Rating Score 7 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as an indication of whether the subject has died.", + "output": "Subject Death Flag (Finding)" + }, + { + "input": "Definition: Laboratory or Test Result described as a semi-quantitative microscopic finding indicating that less than 25 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.", + "output": "Blasts Less than 25 Percent of Bone Marrow Nucleated Cells (Blasts Under 30 Percent of Bone Marrow Nucleated Cells)" + }, + { + "input": "Definition: something described as any process in which the symbiont modulates the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "modulation by symbiont of host G-protein coupled receptor protein signal transduction (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of sinapate ester biosynthesis.", + "output": "regulation of sinapate ester anabolism (Molecular Function)" + }, + { + "input": "Definition: Turntables, Laboratory described as powered laboratory turntables designed for microorganism inoculation in Petri dishes. The turntables typically consist of an electric rotatory mechanism to provide a circular motion to an upper platform allowing even distribution of bacterial colonies in Petri dishes. The upper platform usually includes and anti-skid surface where the Petri dish (up to 10 or 15 cm/4 to 6 inch diameter) is placed. The turntable typically includes on-off, rotation speed, and time controls to improve uniform plating of the dishes. Powered Petri dish turntables are intended to facilitate the placement of concentric circles of microorganisms (e.g., bacteria) from the edge of the dish to its center.", + "output": "Turntables, Petri Dish, Inoculating (Turntables, Laboratory)" + }, + { + "input": "Definition: poly-pyrimidine tract binding described as interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.", + "output": "poly(U) binding (poly-pyrimidine tract binding)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form (FACIT-Dyspnea 10 Item Short Form) Part I. Over the past 7 days, how short of breath did you get with each of these activities?: Preparing Meals.", + "output": "FAC084-Part I: Preparing Meals (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)" + }, + { + "input": "Definition: VEGF-activated platelet-derived growth factor receptor signaling pathway described as a series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.", + "output": "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway (positive regulation of cell migration by vascular endothelial growth factor signaling pathway)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Early Epileptic, Rett/Atypical Rett described as molecular assay reagents intended to identify deletions and duplications in genes associated with Rett syndrome and atypical Rett syndrome, neurodevelopmental disorders that are most frequently diagnosed in girls, and are associated with a variety of symptoms (e.g., progressive loss of hand movements, progressive deficits in communication) that begin to appear at 6 to 12 months of age. Genetic variants at multiple loci have been associated with Rett syndrome and atypical Rett syndrome. These reagents are intended to detect deletions and duplications in multiple Rett syndrome- and atypical Rett syndrome-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Early Epileptic, Rett/Atypical Rett, Del/Dup (Medical Device)" + }, + { + "input": "Definition: Italian translation of Medical Subject Headings described as the biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.", + "output": "Genetic Concepts (Latvian translation of the Medical Subject Headings)" + }, + { + "input": "Definition: Intellectual Product described as works about authoritative resources describing the composition, properties, manufacture, and quality control of HOMEOPATHIC REMEDIES.", + "output": "Homeopathic Pharmacopoeias as Topic (Pharmacopoeias as Topic)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.", + "output": "integrin synthesis (Molecular Function)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a depression in the entorhinal area that marks the ventral boundary of the uncus ( Mai-1997 ).", + "output": "uncal notch (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.", + "output": "maturation of 5S rRNA (rRNA processing)" + }, + { + "input": "Definition: N-glycan processing described as the modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome.", + "output": "N-glycan processing to lysosome (Molecular Function)" + }, + { + "input": "Definition: Non-Neoplastic Heart Disorder described as inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.", + "output": "Constrictive Pericarditis (Disorder of pericardium)" + }, + { + "input": "Definition: Hormone Antagonists described as a derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.", + "output": "Devazepide (Benzodiazepinones)" + }, + { + "input": "Definition: Physiologic Responses described as identifies critical variances in diagnostic studies.", + "output": "Assesses deviation(s) in diagnostic study results (Health Care Activity)" + }, + { + "input": "Definition: Laboratory Procedure described as a microscopy staining method that utilizes both cationic and anionic dyes (typically methylene blue and eosin Y, respectively) for the morphological assessment of cells in a biological specimen.", + "output": "ROMANOWSKY STAIN (Special Histology Staining Method)" + }, + { + "input": "Definition: Occupational Activity described as the industry concerned with the removal of raw materials from the Earth's crust and with their conversion into refined products.", + "output": "Extraction and Processing Industry (Industry)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an insertion of the amino acid glycine between the aspartic acid at position 770 and the asparagine at position 771 of the epidermal growth factor receptor protein.", + "output": "Epidermal Growth Factor Receptor D770 N771insG (EGFR Protein Variant)" + }, + { + "input": "Definition: something described as a chromosome band present on 12q", + "output": "12q13-q15 (Chromosome band)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Young Child Parent Report - In the past one month, how much of a problem has this been for your child: It takes my child a long time to bathe or shower.", + "output": "PQL0813 (Intellectual Product)" + }, + { + "input": "Definition: Gastric Cancer by AJCC v8 Stage described as a term that refers to the clinical staging of gastric cancer according to the American Joint Committee on Cancer, 8th edition.", + "output": "Gastric Cancer by AJCC v8 Clinical Stage (Gastric Cancer by AJCC v8 Stage)" + }, + { + "input": "Definition: something described as the developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.", + "output": "interventricular septum morphogenesis (Organism Function)" + }, + { + "input": "Definition: Severities described as the degree of something undesirable as determined by microscopic findings.", + "output": "Microscopic Findings Severity (Qualitative Concept)" + }, + { + "input": "Definition: Cornea described as stratified squamous epithelium that covers the outer surface of the cornea; it is smooth and contains many free nerve endings.", + "output": "corneal epithelium (Cornea)" + }, + { + "input": "Definition: something described as solid preparation consisting of one or more powders intended to be dissolved in the specified liquid to obtain an endotracheopulmonary instillation solution.", + "output": "Endotracheopulmonary Instillation, Powder for Solution Dosage Form (Powder for Solution Dosage Form)" + }, + { + "input": "Definition: Finding described as a history of a first-degree relative with Marfan syndrome.", + "output": "Family history of Marfan syndrome (Family history)" + }, + { + "input": "Definition: Signs and Symptoms described as effusion and accumulation of serous fluid in the abdominal cavity.", + "output": "peritoneal exudate (Digestion-hydration)" + }, + { + "input": "Definition: Oxidoreductases, N-Demethylating described as an ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.", + "output": "cytochrome P450 2E1 (Cytochrome P450 Family 2)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents.", + "output": "phthiocerol anabolism (glycol biosynthetic process)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a radioimmunoconjugate comprised of a human monoclonal antibody (huMAb-5B1) against the carbohydrate antigen sialyl Lewis A (carbohydrate antigen 19-9; CA19-9) that is conjugated to the chelator 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A''-DTPA) and labeled with the beta-emitting radioisotope lutetium Lu 177 (Lu 177), with radioisotopic activity and potential use as an antineoplastic radiotherapeutic and an imaging agent in both planar imaging and single-photon emission computed tomography (SPECT). The antibody moiety of Lu 177 anti-CA19-9 monoclonal antibody 5B1 targets and binds to CA19-9-expressing tumor cells. This may promote killing of CA19-9-expressing tumor cells through the local induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). Additionally, upon binding and internalization, the Lu 177 moiety can deliver a cytotoxic dose of beta radiation to the CA19-9-expressing tumor cells. Furthermore, the radioisotope moiety may be imaged using planar imaging and SPECT, thus allowing evaluation of the pharmacokinetic profile of the agent, and the imaging and quantification of CA19-9-expressing tumor cells, respectively. CA19-9, a Lewis-type carbohydrate antigen overexpressed on a number of different tumor cell types, plays a key role in tumor cell survival and metastasis.", + "output": "Lu 177 anti-CA19-9 monoclonal antibody 5B1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein.", + "output": "NtQ-amidase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the APC gene that originates in the gametes.", + "output": "Germline APC, WNT Signaling Pathway Regulator Gene Mutation (Germ-Line Mutation)" + }, + { + "input": "Definition: Internationality described as the interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.", + "output": "international cooperation (Internationality)" + }, + { + "input": "Definition: something described as an anomaly of the intra-atrial or intraventricular septum.", + "output": "Defect, Heart Septal (Other specified congenital malformations of heart)" + }, + { + "input": "Definition: Course described as morphologic changes containing characteristics of both acute and chronic, but predominantly acute.", + "output": "Subacute course (General adjectival modifier)" + }, + { + "input": "Definition: Homeopathic remedies letter K described as phosphate of potassium.", + "output": "Kali phosphoricum / potassium phosphate (Inorganic Chemical)" + }, + { + "input": "Definition: Venous cannula insertion described as injecting solution(s), blood and/or medication(s) into a client/patient through a peripheral vein. Service is billed per injection.", + "output": "Intravenous (IV) Insertion (Tissue Perfusion Management)" + }, + { + "input": "Definition: ATPase-coupled transmembrane transporter activity described as catalysis of the reaction: ATP(4-) + cob(I)alamin + H2O <=> ADP(3-) + hydrogenphosphate + cob(I)alamin + H+. Cobalamin is also known as vitamin B12.", + "output": "ATPase-coupled cobalamin transmembrane transporter activity (ATPase-coupled transmembrane transporter activity)" + }, + { + "input": "Definition: Personal assessment described as assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.", + "output": "Neurological Assessment (Examination of body system)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Breast Version 4 (FACT-B Version 4) Additional Concerns: I have been short of breath.", + "output": "FACT-B Version 4 - I Have Been Short of Breath (FACT-B Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Triterpenes described as dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol.", + "output": "ginsenosides (Saponins)" + }, + { + "input": "Definition: something described as physical location of CDC42_Gene", + "output": "1: 22124488-22164742 (Spatial Concept)" + }, + { + "input": "Definition: Molecular Function described as the appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "chemokine (C-X-C motif) ligand 12 production (chemokine production)" + }, + { + "input": "Definition: something described as a unipolar endoscopic coagulator-cutter is a device designed to destroy tissue with high temperatures by directing a high frequency electrical current through the tissue between an energized probe and a grounding plate. It is used in female sterilization and in other operative procedures under endoscopic observation. This generic type of device may include the following accessories: an electrical generator, probes and electrical cables, and a patient grounding plate. This generic type of device does not include devices used to perform female sterilization under hysteroscopic observation.", + "output": "COAGULATOR, CULDOSCOPIC (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as a findings domain that contains measurements including but not limited to blood pressure, temperature, respiration, body surface area, body mass index, height and weight.", + "output": "VS (Domain)" + }, + { + "input": "Definition: Deprivation described as the absence of certain expected and acceptable cultural phenomena in the environment which results in the failure of the individual to communicate and respond in the most appropriate manner within the context of society. Language acquisition and language use are commonly used in assessing this concept.", + "output": "Deprivation, Cultural (cultural factors)" + }, + { + "input": "Definition: West Atlantic language described as a Niger-Congo language spoken by the Serer people of Senegal and Gambia.", + "output": "SRR (West Atlantic language)" + }, + { + "input": "Definition: Pharmacologic Substance described as a photosensitizer composed of the sodium salt form of chlorin e6 and its derivatives complexed with a low-molecular weight polyvinylpyrrolidone (PVP) polymer component, with diagnostic and antineoplastic activities upon photodynamic therapy (PDT). Upon intravenous administration, the photosensitizer phytochlorin-PVP sodium complex preferentially accumulates in hyperproliferative tissues, such as tumors. Local application of light with a certain wavelength to the tumor site results in the absorption of light by this agent, leading to its photoactivation. This results in a photodynamic reaction between phytochlorin and oxygen, which causes the production of reactive oxygen species (ROS), including singlet oxygen molecules, the superoxide ion, and other cytotoxic free radicals. The formation of ROS induces free radical-mediated oxidative DNA damage followed by apoptosis of tumor cells. Chlorin e6-PVP is able to penetrate deeply into tissues and is therefore able to treat hard-to-reach tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C126802\" active clinical trials using this agent.", + "output": "chlorin e6/PVP (Photosensitizing Agents)" + }, + { + "input": "Definition: Body Location or Region described as apical zone of myocardium of left ventricle which is adjacen to the apical inferior and the apical inferolateral zones of myocardium of left ventricle.", + "output": "Zone 16 of myocardium of left ventricle (Body Location or Region)" + }, + { + "input": "Definition: Interleukin Signaling Process described as any physiologic process which occurs in response to ligation of an interleukin receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell. This process is involved in regulating the extent of the extent of the response to receptor binding, and in regulating active populations of T, B and hemopoietic cells.", + "output": "Interleukin Suppression (Physiologic Function)" + }, + { + "input": "Definition: Structure of vein of head described as tributary of lingual vein, each instance of which drains some tongue.", + "output": "Sublingual vein (Entire vein of head and neck)" + }, + { + "input": "Definition: Molecular Genetic Technique described as the uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.", + "output": "transfection (genetic manipulation)" + }, + { + "input": "Definition: Medical Device described as a truncal orthosis is a device intended for medical purposes to support or to immobilize fractures, strains, or sprains of the neck or trunk of the body. Examples of truncal orthoses are the following: Abdominal, cervical, cervical-thoracic, lumbar, lumbo-sacral, rib fracture, sacroiliac, and thoracic orthoses and clavicle splints.", + "output": "ORTHOSIS, THORACIC (Orthotic Devices)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of skin squamous cell carcinoma or other skin carcinomas, following the rules of the TNM AJCC v7 classification system. TNM clinical findings are based on inspection and palpation of the involved area and the regional lymph nodes.", + "output": "Cutaneous Squamous Cell Carcinoma or Other Cutaneous Carcinomas Clinical TNM Finding v7 (Skin Squamous Cell Carcinoma or Other Skin Carcinomas TNM Finding v7)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as providing Christian Science ideas and/or spiritual growth support to a client/patient in a 80-minute, in-office, face-to-face meeting to affect healing and/or curing of his or her body, mind and/or spirit. Any practitioner using this code must be listed in The Christian Science Journal as a Christian Science practitioner.", + "output": "CrsSci suprt inofc ea.80min (Christian Science care)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) In the past 30 days: How much of a problem did you have because of barriers or hindrances in the world around you?", + "output": "WD7D6 2 (Intellectual Product)" + }, + { + "input": "Definition: Mesotheliomas malignant and unspecified described as the reemergence of malignant mesothelioma in the pericardium after a period of remission.", + "output": "Recurrent Pericardial Malignant Mesothelioma (Neoplastic Process)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate, or extent of T cell tolerance induction.", + "output": "regulation of T lymphocyte tolerance induction (Cell Function)" + }, + { + "input": "Definition: Anatomical Abnormality described as the presence of developmental dysplasia of the pancreas.", + "output": "Pancreatic developmental dysplasia (Abnormal pancreas morphology)" + }, + { + "input": "Definition: ANTI-ACNE PREPARATIONS described as a topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.", + "output": "13-RA (Pharmacologic Substance)" + }, + { + "input": "Definition: Negative Diagnosis And Outcome described as a perceived issue with a person's emotional wellbeing.", + "output": "Emotional Problem (Negative Diagnosis And Outcome)" + }, + { + "input": "Definition: Physical Phenomenon or Property described as union of opposing surfaces.", + "output": "Process of adhesion (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a fully-human monoclonal antibody directed against human vascular endothelial growth factor receptor 3 (VEGFR-3; Flt-4) with antiangiogenic activity. Anti-VEGFR-3 monoclonal antibody IMC-3C5 specifically binds to and inhibits VEGFR-3, which may result in inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-3 plays a critical role in the embryonic vascular system development but is restricted postnatally to endothelial cells of lymphatic vessels and found to be expressed in many solid and hematologic malignancies. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95734\" active clinical trials using this agent.", + "output": "IMC-3C5 (Antineoplastic Antibody)" + }, + { + "input": "Definition: something described as solid single-dose preparation consisting of a tablet intended for oral use, in which one or more ingestible sensors are embedded. The sensor is usually not digested, and is usually intended for use with external diagnostic equipment to which it can transmit data such as physiological and behavioural measurements.", + "output": "Tablet with Sensor (Tablet Dosage Form)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL-R2 on the surface of some tumor cells, which may kill the tumor cells. HGS-ETR2 is a type of monoclonal antibody.", + "output": "lexatumumab (Immunologic Factor)" + }, + { + "input": "Definition: something described as rivermead Post Concussion Symptoms Questionnaire - Compared with before the accident, do you now suffer from: Sleep disturbance.", + "output": "RPQ - Sleep Disturbance (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with an endothelin B receptor.", + "output": "endothelin B receptor binding (bombesin receptor binding)" + }, + { + "input": "Definition: something described as a coded value specifying the risk factors associated with administration of the agent for the first time to any human.", + "output": "First In Human Risk Factor Code (Code)" + }, + { + "input": "Definition: Hereditary disorder of musculoskeletal system described as a hereditary renal phosphate-wasting disorder characterised by hypophosphataemia and hypercalciuria associated with rickets and/or osteomalacia. Other features include slow growth, short stature, skeletal deformities, muscle weakness and bone pain that are associated with normal or elevated plasma levels of calcitriol and hyperphosphaturia. Caused by homozygous or compound heterozygous mutations in the SLC34A3 gene encoding a sodium-dependent phosphate transporter (NaPi-IIc/NPT2c). Transmission is autosomal recessive.", + "output": "HHRH - hereditary hypophosphatemic rickets with hypercalciuria (Autosomal recessive hypophosphatemic vitamin D refractory rickets)" + }, + { + "input": "Definition: Organic Chemical described as a short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.", + "output": "Midazolam-containing product (M [Preparations])" + }, + { + "input": "Definition: something described as an embolectomy catheter is a balloon-tipped catheter that is used to remove thromboemboli, i.e., blood clots which have migrated in blood vessels from one site in the vascular tree to another.", + "output": "DEVICE, PERCUTANEOUS RETRIEVAL (Medical Device)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Tumor Lysis Syndrome, CTCAE (Finding)" + }, + { + "input": "Definition: vesicle fusion described as the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome.", + "output": "vesicle fusion with peroxisome (Cell Function)" + }, + { + "input": "Definition: something described as a non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).", + "output": "non-motile 9+0 cilium (non-motile cilium)" + }, + { + "input": "Definition: Study models described as representation of the behavior or activity of genetic processes or systems which can be manipulated to demonstrate the effects that various actions will have on the genetic process or system or organism as a whole.", + "output": "MODELS GENET (Intellectual Product)" + }, + { + "input": "Definition: cellular diagnosis, adult soft tissue sarcoma described as a malignant peripheral nerve sheath tumor occurring during adulthood.", + "output": "Adult Malignant Schwannoma (Malignant Peripheral Nerve Sheath Tumor)" + }, + { + "input": "Definition: Laboratory or Test Result described as a blood concentration of prostate specific antigen between 0 ng/mL and 2 ng/mL.", + "output": "PSA Level 0 to 2 (PSA Level Finding)" + }, + { + "input": "Definition: Non-Occupational Pulmonary Diseases and Syndromes described as a serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date.", + "output": "Neonatal aspiration meconium (Lung)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 516 of the coding sequence of the IDH2 gene where guanine has been mutated to thymine.", + "output": "Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial c.516G>T (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as the directed movement of chloride ions from one side of an epithelium to the other.", + "output": "transepithelial chloride transport (Cell Function)" + }, + { + "input": "Definition: D-amino acid metabolic process described as the chemical reactions and pathways involving D-tyrosine.", + "output": "D-tyrosine metabolism (D-amino acid metabolic process)" + }, + { + "input": "Definition: Finding described as testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion and is 3 cm or larger in size. This pT1 subclassification applies only to pure seminomas.", + "output": "Testicular Cancer pT1b TNM Finding v8 (Testicular Cancer pT1 TNM Finding v8)" + }, + { + "input": "Definition: something described as an educational institution for children that precedes kindergarten.", + "output": "Nursery School (Organization)" + }, + { + "input": "Definition: positive regulation of emericellamide biosynthetic process described as any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process.", + "output": "up-regulation of emericellamide A synthesis (Molecular Function)" + }, + { + "input": "Definition: negative regulation of RNA splicing described as any viral process that inhibits the splicing of host mRNA, thus reducing host protein production.", + "output": "viral dispersion of host splicing factors (Genetic Function)" + }, + { + "input": "Definition: Quantitative Concept described as the fraction of the treatment dose that reaches the systemic circulation relative to a reference route or reference formulation. The ratio of the amount of drug in the system (area under the curve) after administration of a test formulation divided by the drug in the system after a non-IV administration of a reference formulation and/or reference route.", + "output": "FREL (Biological Availability)" + }, + { + "input": "Definition: Body Location or Region described as the more posterior of two parts of primary motor cortex defined on the basis of cytoarchitecture and neurotransmitter binding in the human ( Matelli-2004 ). The more anterior part is area 4a of Geyer. The relation of area 4p to the caudal sector of primary motor cortex, which is defined in the macaque on the basis of function and connectivity, is undetermined.", + "output": "area 4p (Body Location or Region)" + }, + { + "input": "Definition: Estrenes described as an anabolic steroid used mainly as an anabolic agent in veterinary practice.", + "output": "Acetate, Trenbolone (Androgens, Synthetic)" + }, + { + "input": "Definition: something described as an area of great cellular activity and growth, where auxiliary buds develop into leaves or flowers.", + "output": "Node (Plant Part)" + }, + { + "input": "Definition: something described as catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine.", + "output": "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the regulation of histone acetylation.", + "output": "E1A-BINDING PROTEIN, 400-KD (Hydrolase Gene)" + }, + { + "input": "Definition: Molecular Function described as combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.", + "output": "axon guidance receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as a lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment.", + "output": "DISINHIBITION (inhibition and disinhibition)" + }, + { + "input": "Definition: Pharmacologic Substance described as a novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102564\" active clinical trials using this agent.", + "output": "AZD5363 (Organic Chemical)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual thinks that one of three patients who has surgery will need diapers due to very poor control of urine after surgery.", + "output": "One of three patients who has surgery will need diapers due to very poor control of urine after surgery (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Equipment and Supplies described as pieces of glass or other transparent materials used for magnification or increased visual acuity.", + "output": "LENS (Optical Devices)" + }, + { + "input": "Definition: something described as the left bundle branch of His splits into anterior and posterior hemifascicles.", + "output": "Left Bundle Branch of His (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as cytoplasmic noncellular membrane surrounding the eggs of various animals, especially the membrane enveloping the yolk of telolecithal eggs.", + "output": "Membrane, Vitelline (Ovum)" + }, + { + "input": "Definition: something described as the attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.", + "output": "cell-cell adhesion mediated by integrin complex (Cell Function)" + }, + { + "input": "Definition: Chemokine receptor antagonist described as an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation.", + "output": "CCR2 antagonist PF-04136309 (Pharmacologic Substance)" + }, + { + "input": "Definition: Population Group described as a person having origins in any of the black racial groups of Africa. Terms such as Haitian or Negro can be used in addition to Black or African American.", + "output": "United States Black (US minority racial or ethnic group)" + }, + { + "input": "Definition: Laboratory or Test Result described as an indication that ANPEP expression has not been detected in a sample.", + "output": "Microsomal Aminopeptidase Negative (Expression Negative)" + }, + { + "input": "Definition: pyrimidine nucleoside diphosphate metabolic process described as the chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.", + "output": "pyrimidine ribonucleoside diphosphate metabolism (pyrimidine nucleoside diphosphate metabolic process)" + }, + { + "input": "Definition: guanine described as a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.", + "output": "L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)- (Pharmacologic Substance)" + }, + { + "input": "Definition: Clostridium species q-z described as any bacterial organism that can be assigned to the species Clostridium sartagoforme.", + "output": "Clostridium sartagoforme (Bacterium)" + }, + { + "input": "Definition: Quantitative Concept described as a scale for rating the level of sunburn protection in sunscreen products. The higher the sun protection factor, the more sunburn protection it gives. Sunscreens with a value of 2 through 11 give minimal protection against sunburns. Sunscreens with a value of 12 through 29 give moderate protection. Sun protection factors of 30 or higher give high protection against sunburn.", + "output": "SPF (chemical properties)" + }, + { + "input": "Definition: something described as this table is used to store responses to patient-reported outcome measures (PROs) or questionnaires. This table can be used to store item-level responses as well as the overall score for each measure.", + "output": "PRO CM (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+).", + "output": "aminoacetone synthase activity (Molecular Function)" + }, + { + "input": "Definition: Recurrent viral infection described as increased susceptibility to enteroviral infections, as manifested by recurrent episodes of enteroviral infection.", + "output": "Recurrent enteroviral infections (Finding)" + }, + { + "input": "Definition: something described as a proprietary topical formulation consisting of a high-concentration of hydrogen peroxide (H2O2), with potential keratolytic activity. Upon administration of the A-101 topical solution to an affected area of skin, the hydrogen peroxide penetrates into the cells, increases oxygen content, produces reactive oxygen species (ROS), causes oxidative stress and induces apoptosis through oxidative damage. This may clear the affected skin cells and remove common warts (verruca vulgaris) or seborrheic keratosis (SK).", + "output": "A-101 solution (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as patients with cardiac disease resulting in slight limitation of physical activity. They are comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnea, or anginal pain.", + "output": "Class II Angina (Canadian Cardiovascular Society Grading Scale Class)" + }, + { + "input": "Definition: something described as for example: -Walk, medium pace -Carry a heavy load on level ground", + "output": "5 - Moderate (Finding)" + }, + { + "input": "Definition: localization of cell described as directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.", + "output": "oocyte localization involved in germarium-derived egg chamber formation (Biologic Function)" + }, + { + "input": "Definition: stimulant/agonist described as agent which mimics, potentiates, or enhances the pharmacological effect of a neurotransmitter; prefer NTs.", + "output": "neurotransmitter agonist (stimulant/agonist)" + }, + { + "input": "Definition: something described as an isobaric tags for relative and absolute quantitation reagent preparation that is coupled to a carbonyl-reactive hydrazide group that enables labeling and quantitative profiling of glycopeptides, carbohydrates, steroids, or oxidized proteins.", + "output": "iTRAQH (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Quantitative Concept described as a numeric comparison of the weight of an organ to the weight of the brain.", + "output": "OWBR (Quantity Ratio)" + }, + { + "input": "Definition: Finding described as repair or revision not indicated", + "output": "Grade 2 Injury to carotid artery (Injury To Carotid Artery, CTCAE 5)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid.", + "output": "N-acyl-D-amino acid amidohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Mycelium described as any of the threadlike filaments forming the mycelium of a fungus.", + "output": "Fungal hyphae (Fungus)" + }, + { + "input": "Definition: something described as human MST1L wild-type allele is located 1p36.13 and is approximately 15 kb in length. This allele encodes putative macrophage-stimulating protein MSTP9, a non-functional member of the peptidase S1 family.", + "output": "MSTP9 (Gene or Genome)" + }, + { + "input": "Definition: something described as evaluating and managing an existing client in a comprehensive, 60-minute, in-facility meeting. This code may be used by providers of services who are able to diagnose.", + "output": "Comprehensive existing in-facility 60 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Mental Process described as perceived degree of physical well-being in response to internal or environmental conditions.", + "output": "Physical comfort (Comfort)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of trisporic acid.", + "output": "trisporic acid biosynthetic process (trisporic acid metabolic process)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as a measurement of the amount of Pi Glutathione-S-Transferase being excreted in a biological specimen over a defined period of time (e.g. one hour).", + "output": "GSTPIEXR (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Biomedical and Dental Materials described as synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.", + "output": "Biomedical Material (Drug, Food, Chemical or Biomedical Material)" + }, + { + "input": "Definition: something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Ideational praxis task for folding the paper.", + "output": "CDISC ADAS-Cog - Ideational Praxis: Fold (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: Leukemia, Myelocytic, Acute described as form of acute myeloid leukaemia having a shortage of all types of mature blood cells with onset in childhood or young adulthood.", + "output": "CBF-AML - core binding factor acute myeloid leukemia (Neoplastic Process)" + }, + { + "input": "Definition: Radioconjugate described as a radioconjugate and glutamine analog consisting of the fluorine F 18 labeled 2S, 4R stereoisomer of 4-fluoroglutamine with potential use as a metabolic tracer for tumor imaging. Upon intravenous administration, fluorine F 18 4-L-fluoroglutamine (2S,4R) is preferentially taken up by cancer cells, possibly driven by c-Myc upregulation. Upon positron emission tomography (PET), cancer cells can be imaged. Tumor cells use the amino acid glutamine for nutritional purposes necessary for energy production and growth; as tumor cells proliferate more rapidly than normal healthy cells, glutamine uptake is higher in certain cancer cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C103196\" active clinical trials using this agent.", + "output": "fluorine F 18 4-L-fluoroglutamine (Pharmacologic Substance)" + }, + { + "input": "Definition: PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - During the last week, has it been easy or hard for your child to: Climb one flight of stairs?", + "output": "PODCI Pediatric Parent-Reported Version - Climb One Flight of Stairs (PODCI Pediatric Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the small coiled tubes in the skin that produce and secrete sweat.", + "output": "sudoriferous gland (Skin)" + }, + { + "input": "Definition: Child health procedures described as conditioning to defecate and urinate in culturally acceptable places.", + "output": "Trainings, Toilet (Training)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as a rare genetic persistent combined dystonia disorder characterized by slowly progressive severe caudo-rostrally spreading generalized dystonia with prominent facial and oro-mandibular involvement leading to severe anarthria and/or aphonia, swallowing difficulties and gait disturbances. Additional manifestations include slowed horizontal saccades, subclinical epilepsy, photic myoclonus, oral hypertrophic changes (for example gingival or lingual hyperplasia) as well as delayed milestones and cognitive impairment.", + "output": "Dystonia aphonia syndrome (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Aggressive Non-Hodgkin Lymphoma described as an aggressive non-Hodgkin lymphoma that has recurred after a period of remission.", + "output": "Recurrent Aggressive Non-Hodgkin Lymphoma (Aggressive Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as class E basic helix-loop-helix protein 22 (381 aa, ~37 kDa) is encoded by the human BHLHE22 gene. This protein is involved in the suppression of gene transcription.", + "output": "Class B Basic Helix-Loop-Helix Protein 5 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Dosing instruction fragment described as used to indicate that an event is to immediately follow another event.", + "output": "Upon - dosing instruction fragment (Functional Concept)" + }, + { + "input": "Definition: Finding described as anterior orbital involvement (+/- conjunctival involvement + lacrimal involvement).", + "output": "Ocular Adnexal Lymphoma pT2b TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Proximal superior mesenteric lymph node group described as proximal superior mesenteric lymph node group around the main trunk of superior mesenteric artery.", + "output": "Area 14a lymph node group (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Abnormality of Krebs cycle metabolism described as a decreased rate of pyruvate carboxylase activity.", + "output": "Decreased pyruvate carboxylase activity (Abnormality of Krebs cycle metabolism)" + }, + { + "input": "Definition: cell fate commitment described as the commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.", + "output": "cell fate commitment involved in formation of primary germ layer (cell fate commitment)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Insufficient Evidence for Diagnosis of Fetal Growth Restriction is defined as the absence of an ultrasound for use in the assessment of estimated fetal weight.", + "output": "Insufficient Evidence for Fetal Growth Restriction (GAIA Fetal Growth Restriction Level of Diagnostic Certainty)" + }, + { + "input": "Definition: Physical Chemical Technique described as separation of particles into size-differentiated fractions.", + "output": "Particle Sizing (Physical Chemical Technique)" + }, + { + "input": "Definition: Symptoms and signs involving emotional state described as abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.", + "output": "Irritable Moods (psychosocial interdependence)" + }, + { + "input": "Definition: Research Activity described as the completed process of evaluating a product after it has been returned to the manufacturer or reprocessor.", + "output": "PerformedProductInvestigation (Performed Clinical Study Activity)" + }, + { + "input": "Definition: Finding described as a response indicating that an individual is quite able to do something.", + "output": "Quite a bit (Finding)" + }, + { + "input": "Definition: something described as signal transduction in which the initial step occurs in a presynapse.", + "output": "presynaptic signaling pathway (Cell Function)" + }, + { + "input": "Definition: Adaptor Proteins, Signal Transducing described as FAS-associated death domain protein (208 aa, ~23 kDa) is encoded by the human FADD gene. This protein is involved in the positive regulation of caspase-dependent apoptosis.", + "output": "Protein FADD (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Immunologic Deficiency Syndromes described as a condition of decreased or absent presence or activity of SH2 domain protein 1A. Deficiency of this protein is associated with X-linked lymphoproliferative syndrome 1 (Duncan Disease).", + "output": "X-linked Lymphoproliferative Syndrome 1 (Immunologic Deficiency Syndromes)" + }, + { + "input": "Definition: something described as enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.", + "output": "lipopolysaccharide transmembrane transporter activity (carbohydrate derivative transmembrane transporter activity)" + }, + { + "input": "Definition: Drug-related disorder described as maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems.", + "output": "rndx substance abuse (MedlinePlus Health Topics)" + }, + { + "input": "Definition: Iron Metabolism Disorders described as accumulation of iron in internal organs that results from repeated blood transfusions.", + "output": "Transfusion Hemosiderosis (Hemosiderosis)" + }, + { + "input": "Definition: something described as the National Institute of General Medical Sciences (NIGMS) primarily supports basic biomedical research that is not targeted to specific diseases or disorders.", + "output": "National Institute of General Medical Sciences (Component of the National Institutes of Health)" + }, + { + "input": "Definition: something described as short tubes or cannulae with an outer plug designed to be placed in the opening created by a tracheostomy. Tracheostomy buttons do not extend into the trachea. These devices are usually used to prevent the narrowing of the tracheostomy stoma during intermittent use of a tracheostomy tube. They can also be used for attaching devices such as speaking valves or for suctioning mucus. Tracheostomy buttons may be made of polymer or silicone.", + "output": "Tracheostomy button (Anesthesia/Respiratory Equipment and Supplies)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subunit of the interleukin-18 receptor that plays a role in receptor signaling by association of its cytoplasmic domain with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.", + "output": "INTERLEUKIN 018 RECEPTOR BETA SUBUNIT (CD Antigens)" + }, + { + "input": "Definition: cell fate commitment described as the cell fate commitment of precursor cells that will become trophectoderm cells.", + "output": "trophectoderm cell fate commitment (Cell Function)" + }, + { + "input": "Definition: something described as a surgical procedure to place a stent within a vessel.", + "output": "Stenting (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant urinary system neoplasm that has developed in relatives of patients with a history of malignant urinary system neoplasm.", + "output": "Hereditary Malignant Urinary System Neoplasm (Hereditary Malignant Neoplasm)" + }, + { + "input": "Definition: something described as a directive to specify the other non-neoplastic finding.", + "output": "Specify Other Non-Neoplastic Finding (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as hearing loss, mental retardation, ataxia, hypogonadism, peripheral muscle wasting, and ketoaciduria progressing from childhood and eventually becoming static.", + "output": "Ataxia-deafness-retardation syndrome with ketoaciduria (Disease or Syndrome)" + }, + { + "input": "Definition: transmembrane signaling receptor activity described as combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.", + "output": "odorant receptor activity (Molecular Function)" + }, + { + "input": "Definition: Eye Neoplasms described as ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions.", + "output": "Ocular Paraneoplastic Syndromes (Disease or Syndrome)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the branch of pharmacology that deals with the nature and effects of poisonous substances on reproduction and development.", + "output": "DART (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Cardiovascular injury described as full thickness disruption in the integrity of a blood vessel wall.", + "output": "Rupture of Vessel (Injury or Poisoning)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with interleukin-23.", + "output": "interleukin-23 binding activity (Molecular Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide.", + "output": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer.", + "output": "ClpYQ protease complex (ATPase complex)" + }, + { + "input": "Definition: Magnoliopsida described as a large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of \"daisy\" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.", + "output": "FAMILY ASTERACEAE - COMPOSITAE - COMPOSITE (Asterales)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a composite structure of the TELENCEPHALON that is defined by connectivity. It includes the NUCLEUS ACCUMBENS; the ISLANDS OF CALLEJA; and parts of the CAUDATE NUCLEUS; the PUTAMEN; and the SUBSTANTIA INNOMINATA.", + "output": "Striatum, Ventral (Striatum of neuraxis)" + }, + { + "input": "Definition: something described as 3-carbon saturated monocarboxylic acids.", + "output": "Propionic Acids (Propionates)" + }, + { + "input": "Definition: Geographic Area described as a country in Northern Europe, bordering the North Sea and the North Atlantic Ocean, west of Sweden.", + "output": "Norway (Scandinavia)" + }, + { + "input": "Definition: positive regulation of monooxygenase activity described as the process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity.", + "output": "activation of tryptophan 5-monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a document providing formal acknowledgement of a grant application's approval for funding.", + "output": "Notice of Grant Award (Intellectual Product)" + }, + { + "input": "Definition: something described as an abnormality of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.", + "output": "Bracket shaped end part of little finger bone (Anatomical Abnormality)" + }, + { + "input": "Definition: cellular macromolecule catabolic process described as the chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "output": "Other glycan degradation (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in apoptosis.", + "output": "CLPTM1-Like Gene (Apoptosis Regulation Gene)" + }, + { + "input": "Definition: Receptor described as triggering receptor expressed on myeloid cells 2 (230 aa, ~25 kDa) is encoded by the human TREM2 gene. This protein plays a role in macrophage and dendritic cell immune responses.", + "output": "TREM2 receptor protein, human (Receptor)" + }, + { + "input": "Definition: something described as catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.", + "output": "tRNA methyltransferase activity (catalytic activity, acting on a tRNA)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic derivative of inosinic acid with antiretroviral and immunomodulatory activities. Rintatolimod acts through a number of pathways to stimulate the antiviral activity of the immune system. This agent stimulates interferon production; activates the oligoadenylate synthase-RNase L pathway; stimulates natural killer cell activity; and acts as a non-mitogenic stimulator of the immune system. Rintatolimod also inhibits replication of the human immunodeficiency virus (HIV) in vitro. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1001\" active clinical trials using this agent.", + "output": "Poly(Inosinic Acid) Poly(Cytidylic(12), Uridylic)Acid (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: molting cycle described as the periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.", + "output": "chitin-based cuticle molting cycle (Organism Function)" + }, + { + "input": "Definition: Stage III Liver Cancer described as for hepatocellular carcinoma: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. For intrahepatic cholangiocarcinoma: Stage III includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum or involving the local extra hepatic structures by direct invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage III Liver Cancer (Stage III Liver Cancer)" + }, + { + "input": "Definition: cytokine described as t lymphocyte derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B lymphocytes; it appears to play a role in regulating inflammatory and immune responses.", + "output": "IL 013 (Immunologic Factor)" + }, + { + "input": "Definition: Protein Interaction Mapping described as methods used for studying the interactions of antibodies with specific regions of protein antigens; important applications of epitope mapping are found within the area of immunochemistry.", + "output": "epitope mapping (Molecular Biology Research Technique)" + }, + { + "input": "Definition: Finding described as soft tissue sarcoma with deep tumor measuring 5 cm or less in greatest dimension.", + "output": "Soft Tissue Sarcoma pT1b TNM Finding v7 (Soft Tissue Sarcoma pT1 TNM Finding v7)" + }, + { + "input": "Definition: Embolism described as presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the antepartum period.", + "output": "Antepartum Obstetric Septic Embolism (Embolism)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as molecular assay reagents intended for use in identifying exchanges between chromosome 12 band p13 and chromosome 15 band q25, usually involving genes ETV6 and NTRK3, respectively. This translocation is characteristic of infantile fibrosarcoma; the mutation is also associated with mesoblastic nephroma and found in a subset of patients with multiple myeloma. Its detection may be used as a tumor marker.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(12;15)(p13;q25) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(12;15))" + }, + { + "input": "Definition: General adjectival modifier described as having a narrow part by which some larger part is attached.", + "output": "pedunculated (Spatial Concept)" + }, + { + "input": "Definition: something described as this gene is involved in nucleotide excision repair and corrects sensitivity to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group D.", + "output": "DNA REPAIR DEFECT EM9 OF CHINESE HAMSTER OVARY CELLS, COMPLEMENTATION OF (Gene or Genome)" + }, + { + "input": "Definition: Pharmacologic Substance described as a flavone with two hydroxyl groups on the B-ring and a second hydroxyl group on the A-ring.", + "output": "3',4',5,7-Tetrahydroxyflavone (Flavones)" + }, + { + "input": "Definition: Endothelium, Vascular described as the innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.", + "output": "Intima, Vascular (Blood vessel part)" + }, + { + "input": "Definition: something described as a non-neoplastic or neoplastic disorder that affects the structures of the chest wall. Representative examples include infection, chest wall lipoma, and chest wall lymphoma.", + "output": "Chest Wall Disease (Thoracic Diseases)" + }, + { + "input": "Definition: something described as the directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups.", + "output": "sodium-independent leukotriene transport (leukotriene transport)" + }, + { + "input": "Definition: Recurrent Indolent Adult Non-Hodgkin Lymphoma described as the reemergence of adult diffuse small cleaved cell lymphoma after a period of remission. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8159\" active clinical trials using this agent.", + "output": "adult diffuse small cleaved cell lymphoma, relapsed (Adult Diffuse Small Cleaved Cell Lymphoma)" + }, + { + "input": "Definition: something described as a purified, natural saponin isolated from the soapbark tree Quillaja saponaria Molina with potential immunoadjuvant activity. When co-administered with a vaccine, OBI-821 may increase antibody and cytotoxic T-lymphocyte (CTL) responses against the vaccine's targeted antigen(s). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91726\" active clinical trials using this agent.", + "output": "Saponin-based Immunoadjuvant OBI-821 (Organic Chemical)" + }, + { + "input": "Definition: PAGR1 gene described as human PAGR1 wild-type allele is located in the vicinity of 16p11.2 and is approximately 6 kb in length. This allele, which encodes PAXIP1-associated glutamate-rich protein 1, is involved in the regulation of both gene transcription and histone methylation.", + "output": "Chromosome 16 Open Reading Frame 53 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as an aggressive mucoepidermoid carcinoma characterized by the presence of focal necrosis and high mitotic activity. Lymph node and distant metastases are common. The prognosis is usually poor.", + "output": "High-Grade Mucoepidermoid Carcinoma of the Breast (Mucoepidermoid Breast Carcinoma)" + }, + { + "input": "Definition: something described as reagents consisting of a substance that is established as a norm and compared with similar reagents used in immunoassay tests performed to determine one or more of a group of drugs that have a high potential of abuse. Standard reagents may be used to determine the purity or performance of the reagents used in those tests.", + "output": "IVD Test Reagent/Kits, Immunoassay, Standard, Drug-of-Abuse (IVD Test Reagent/Kits, Immunoassay, Standard)" + }, + { + "input": "Definition: Genetic Engineering described as any of the techniques that produce identical individuals.", + "output": "Cloning (Genetic Engineering)" + }, + { + "input": "Definition: Hematology procedure described as a measurement of the total erythrocytes in a biological specimen.", + "output": "red blood cell count (Red Blood Cell Count measurement)" + }, + { + "input": "Definition: Health described as the health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.", + "output": "health family (Health)" + }, + { + "input": "Definition: Polycythaemia described as increase in the total red cell mass of the blood.", + "output": "POLYCYTHAEMIA (Leukopenia)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: L-aspartate = fumarate + NH3.", + "output": "fumaric aminase activity (ammonia-lyase activity)" + }, + { + "input": "Definition: Gene or Genome described as human ARHGEF12 wild-type allele is located in the vicinity of 11q23.3 and is approximately 153 kb in length. This allele, which encodes Rho guanine nucleotide exchange factor 12 protein, is involved in the modulation of signaling that is mediated by both Rho-family GTPases or G-protein coupled receptors. The gene is involved in a translocation t(11;11)(q23;23) with the MLL gene which is associated with acute leukemia.", + "output": "PRO2792 (Gene or Genome)" + }, + { + "input": "Definition: Medical Informatics Applications described as research regarding the systematic process of collecting and cataloging data so that they can be located and displayed on request.", + "output": "information retrieval (Medical Informatics Applications)" + }, + { + "input": "Definition: something described as sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.", + "output": "blood group antigens (Isoantigens)" + }, + { + "input": "Definition: Protein Family described as a family of prenylated protein tyrosine phosphatases that plays a role in both phosphotyrosine catabolism and signal transduction pathways, which in turn modulate many different cellular processes.", + "output": "Protein Tyrosine Phosphatase Type IVA (Protein Family)" + }, + { + "input": "Definition: Omaha System described as patterns of behavior, emotion, communication, relationships, and development.", + "output": "PSYCHOSOCIAL DOMAIN (Omaha System)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.", + "output": "Lacrimal Gland Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 (Lacrimal Gland Carcinoma Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Receptors, Cytokine described as cytokine receptor-like factor 2 (371 aa, ~42 kDa) is encoded by the human CRLF2 gene. This protein is involved in the mediation of both cytokine binding and signaling.", + "output": "TSLPR protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Data described as information collected from a subject and presented on a case report form.", + "output": "CRF Data (Intellectual Product)" + }, + { + "input": "Definition: Micrococcaceae described as a genus of high GC-content, Gram-positive ACTINOBACTERIA in the family MICROCOCCACEAE. The type species of this genus, Renibacterium salmoninarum, is known to cause bacterial kidney disease in SALMONIDS.", + "output": "Renibacterium species (Renibacterium)" + }, + { + "input": "Definition: Manufactured Object described as electric signal amplifiers designed for simultaneous amplification of video (typically in the VHF and/or UHF bands) and audio signals (typically in a range from a few hundred hertz to 20 kHz). These devices typically consist of a wide-band, high-fidelity, electronic amplifier with audio and video signal inputs, electronic circuits to amplify the signal for both the audio and video channels, controls (e.g., gain, contrast), appropriate output ports for the amplified signals, and a power supply. Video/audio amplifiers are used mainly in hospital information and communication systems to compensate for transmission losses in remote cable connections throughout the facility.", + "output": "Video/Audio Signal Amplifiers (Manufactured Object)" + }, + { + "input": "Definition: Genetic Function described as a triplet codon-amino acid adaptor activity that recognizes an ACU codon.", + "output": "ACU codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: cis-trans isomerase activity described as catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate.", + "output": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity (Molecular Function)" + }, + { + "input": "Definition: something described as human MARK1 wild-type allele is located in the vicinity of 1q41 and is approximately 136 kb in length. This allele, which encodes serine/threonine-protein kinase MARK1 protein, is involved in both microtubule dynamics and protein phosphorylation.", + "output": "MARK1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: ERCC5 gene described as human ERCC5 wild-type allele is located in the vicinity of 13q33.1 and is approximately 30 kb in length. This allele, which encodes DNA-repair protein complementing XP-G cells protein, is involved in the transcription-coupled repair of ultraviolet-induced DNA damage.", + "output": "ERCM2 (ERCC5 gene)" + }, + { + "input": "Definition: something described as a response indicating that an individual is unemployed due to quitting, being fired, or retirement.", + "output": "Unemployed or Retired (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Gene or Genome described as human LCN2 wild-type allele is located in the vicinity of 9q34 and is approximately 5 kb in length. This allele, which encodes neutrophil gelatinase-associated lipocalin protein, may be involved in both the modulation of inflammation and the regulation of the transport of hydrophobic substances (ie. retinol, lipopolysaccharide). The expression of this gene may be elevated in many cancers and inflammatory diseases.", + "output": "Lipocalin 2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as human MEF2A wild-type allele is located in the vicinity of 15q26 and is approximately 150 kb in length. This allele, which encodes myocyte-specific enhancer factor 2A protein, is involved in both myogenesis and growth factor or stress-stimulated transcriptional regulation.", + "output": "RSRFC9 (Gene or Genome)" + }, + { + "input": "Definition: Organic Chemical described as a radiopaque hydrogel containing cross-linked, iodinated polyethylene glycol (PEG) particles in a viscous carrier, with potential use as a contrast agent to enhance marking of soft tissue during a surgical procedure and concomitant radiotherapy upon computed tomography (CT), magnetic resonance (MR) and ultrasound imaging. Upon intratumoral injection, iodinated PEG-based hydrogel tissue marker localizes to and is maintained in soft tissue. Upon MR, ultrasound and/or CT imaging, the visualization of the tumor tissue is enhanced, which can facilitate tumor removal and image-guided radiotherapeutic treatment. The hydrogel particles are stable and visible through 3 months, after which they liquefy, and are absorbed by the body and cleared in the urine. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C133359\" active clinical trials using this agent.", + "output": "radiopaque polymer hydrogel imaging agent (Iodinated Contrast Agent)" + }, + { + "input": "Definition: Behavioral, Psychological or Informational Intervention described as a resilience-building intervention program for adolescents and young adults with serious illness. It focuses of 4 disease-non-specific skills: stress management, goal-setting and problem-solving, positive re-appraisals of stressors, and meaning-making or benefit-finding.", + "output": "Promoting Resilience in Stress Management (Health Care Activity)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a population of allogeneic, cytokine-differentiated, highly lytic natural killer (NK) cells derived from CD34+ cells isolated from human umbilical cord blood (UCB) with potential cytotoxic activity. CD34+ hematopoietic stem cells (HSC) are isolated from human UCB mononuclear cells, differentiated into mature, highly lytic, CD3- CD56+ NK cells, by a specific combination of cytokines that includes stem cell factor (SCF), fms-related tyrosine kinase 3 ligand (Flt3-L), interleukin-15 (IL-15) and insulin-like growth factor-1 (IGF-1), and expanded ex vivo. Upon administration, the UCB-derived NK cells may lyse cancer cells.", + "output": "umbilical cord blood-derived natural killer cells (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Chromatography Systems, Liquid, Packed Column described as a high pressure liquid chromatography system for clinical use is a device intended to separate one or more drugs or compounds from a solution by processing the mixture of compounds (solutes) through a column packed with materials of uniform size (stationary phase) under the influence of a high pressure liquid (mobile phase). Separation of the solutes occurs either by absorption, sieving, partition, or selective affinity.", + "output": "LIQUID CHROMATOGRAPHY, HIGH PERFORMANCE (Chromatography Systems, Liquid, Packed Column)" + }, + { + "input": "Definition: Enzyme described as a nuclease-stabilized synthetic ribozyme (ribonucleic acid enzyme) with potential anti-angiogenesis activity. Ribozyme RPI.4610 specifically recognizes the mRNA for FLT1 (vascular endothelial growth factor receptor 1; VEGFR1), and hydrolyzes the mRNA, thereby preventing VEGFR1 proteins from being made. This may prevent VEGF-stimulated angiogenesis in cancerous tissue and metastasis.", + "output": "Ribozyme RPI.4610 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Microbiology, Bacteria, Identification described as microbiology reagents intended to identify bacteria that do not ferment sugars (i.e., nonfermentative) when cultured under specified conditions; these bacteria are typically gram-negative; many of them are part of the normal flora on the mucous membranes in humans and animals. Nonfermenting bacteria also include bacteria that may become pathologic under certain conditions, including Pseudomonas (e.g., Pseudomonas aeruginosa) and some genera (e.g., Moraxella) of the family Neisseriaceae. These reagents may be specific for either manual or automated tests; reagents for identification of particular genera, types, and/or subtypes (e.g., P. aeruginosa) are available.", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Nonfermenter (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification)" + }, + { + "input": "Definition: Cell Count described as the determination of the amount of ringed sideroblasts present in a sample.", + "output": "Ring Sideroblast Measurement (Cell Count)" + }, + { + "input": "Definition: Dosage Form and Package Type described as medicinal product consisting of a suspension for injection presented in a cartridge.", + "output": "Suspension for Injection in Cartridge (Biomedical or Dental Material)" + }, + { + "input": "Definition: Action described as the process whereby heat changes the water component from a solid to a liquid.", + "output": "Thaw Technique (Action)" + }, + { + "input": "Definition: oxyquinoline described as 1,4-dihydroxybenzene.", + "output": "p-Dihydroxybenzene (Photographic chemical product)" + }, + { + "input": "Definition: Intellectual Product described as a question about how often an individual feels or felt of equal worth to other women.", + "output": "How Often Felt of Equal Worth to Other Women (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: HMGN Family Gene described as this gene plays a role in chromatin remodeling and enhancing gene transcription from chromatin templates.", + "output": "HMGN4 Gene (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as cup-like receptacles designed to be placed in the vagina in order to collect menstrual fluid.", + "output": "Menstrual Cups (Collector device)" + }, + { + "input": "Definition: something described as an illegal drug composed of the smokable, baseform of cocaine that is produced by dissolving cocaine hydrochloride in an alkali solution, usually sodium bicarbonate and water, and subsequent boiling. Cocaine causes euphoria, loss of appetite, insomnia, and is highly addictive.", + "output": "cocaine crack (Esters)" + }, + { + "input": "Definition: something described as a pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity. Upon administration of the pegylated liposomal mitomycin C lipid-based prodrug, the MLP moiety becomes activated upon thiolysis at the tumor site, thereby releasing mitomycin C. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. The thiolytic environment and upregulated expression of thioredoxins at the tumor site allow for the activation and release of mitomycin C. This prodrug formulation allows for greater circulation time, less systemic toxicity and increased accumulation of mitomycin C at the tumor site.", + "output": "PL-MLP (Mitomycins)" + }, + { + "input": "Definition: Intervals of hours described as every ten hours.", + "output": "Q10H (Schedule Frequency)" + }, + { + "input": "Definition: Food described as carbonated water which also contains sodium or potassium salts.", + "output": "Club Soda (Food)" + }, + { + "input": "Definition: something described as congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA.", + "output": "SPINA BIFIDA CONGENITAL (Congenital anomaly of skeletal bone)" + }, + { + "input": "Definition: Medical Device described as cervicothoracic immobilizer orthoses designed for maximum restriction of movements and/or total immobilization (i.e., motion control) of the cervical and thoracic (trunk) segments of the spine using a sternal plate. These orthoses consist of rigid structures that include a sternal plate with shoulder extensions and both mandibular and occipital pads and bars. Sternal immobilizer orthoses provide good flexion control of the cervical spine; they are used for long-term treatment of spinal fractures and less frequently to alleviate spinal pain.", + "output": "Sternal Occipital Mandibular Orthoses (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as interleukin-13 receptor subunit alpha-1 (427 aa, ~49 kDa) is encoded by the human IL13RA1 gene. This protein is involved in cytokine-mediated signal transduction.", + "output": "IL-13RA1 (Immunologic Factor)" + }, + { + "input": "Definition: Principles of law and justice described as a legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities.", + "output": "Mandatory Report (Adverse Event and Product Problem Report)" + }, + { + "input": "Definition: Severities described as the qualitative measurement of the severity of cardiac valvular stenosis.", + "output": "CVLSTNS (Severities)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein family that is comprised of the catalytic components of the RNA-induced silencing complex.", + "output": "Argonaute (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as an indication that less than 5 minutes passes between waking and smoking the first cigarette of the day.", + "output": "Within 5 Minutes (Finding)" + }, + { + "input": "Definition: Adenocarcinoma, metastatic described as a carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.", + "output": "Metastatic Adrenal Cortex Carcinoma (Adenocarcinoma, metastatic)" + }, + { + "input": "Definition: something described as an immunoglobulin G4 (IgG4) humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1; PD1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, genolimzumab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.", + "output": "Genolimzumab (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the branch of oncology that focuses on tumors of the reproductive tract of women.", + "output": "Gynecological oncology (Clinical specialty)" + }, + { + "input": "Definition: Fragmentation of the epiphyses of the 5th finger described as fragmented appearance of the epiphysis of the proximal phalanx of the 5th finger.", + "output": "Fragmentation of end part of the innermost bone of the pinky finger (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of sorafenib that may be used in the treatment of soft tissue sarcoma; gastrointestinal stromal and desmoid tumors (aggressive fibromatoses); follicular, medullary, papillary and Hurthle cell thyroid carcinomas; bone, hepatobiliary, and kidney cancers.", + "output": "Sorafenib Tosylate Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Data Collection Methods described as the act of regarding attentively and studying facts and occurrences, gathering data through analyzing, measuring, and drawing conclusions, with the purpose of applying the observed information to theoretical assumptions. Observation as a scientific method in the acquisition of knowledge began in classical antiquity; in modern science and medicine its greatest application is facilitated by modern technology. Observation is one of the components of the research process.", + "output": "Observation (Methods)" + }, + { + "input": "Definition: Expanded DRS-PI Survivor Version Questionnaire Question described as expanded Disability Rating Scale - Postacute Interview Survivor Version (Expanded DRS-PI Survivor Version) Can you function with complete independence in work or social situations?", + "output": "ED208 1 (Intellectual Product)" + }, + { + "input": "Definition: something described as any of the superficial veins located within the muscles of the posterior lower leg, including the gastrocnemial and soleal veins.", + "output": "Calf Muscular Vein (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual is or was able to make decisions and take responsibility.", + "output": "I am able to make decisions and take responsibility (Findings-Based Question)" + }, + { + "input": "Definition: Adenocarcinoma of breast described as a breast carcinoma characterized by the presence of a ductal carcinoma in situ component and an invasive lobular carcinomatous component.", + "output": "Mixed Lobular and Ductal Breast Carcinoma (Ductal Breast Carcinoma In Situ and Invasive Lobular Carcinoma)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.", + "output": "negative regulation of lipoprotein transport (negative regulation of protein transport)" + }, + { + "input": "Definition: something described as molecular assay reagent intended to identify gene variants associated with hereditary pancreatitis, a disorder characterized by recurrent episodes of pancreatic inflammation. Genetic variants at multiple loci have been associated with hereditary pancreatitis. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in hereditary pancreatitis-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Pancreatic Disorder, Pancreatitis (Medical Device)" + }, + { + "input": "Definition: Protein Methyltransferases described as enzyme that transfers methyl groups from O(6) methylguanine and other methylated moities of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single step reaction", + "output": "METHYLGUANINE METHYLTRANSFERASE O 06 (Protein Methyltransferases)" + }, + { + "input": "Definition: medical specialty by body system described as medical specialty dealing with the diagnosis and treatment of psychosomatic disorders.", + "output": "Psychosomatic Medicine (Psychiatry Specialty)" + }, + { + "input": "Definition: something described as a measurement of the banded basophils in a biological specimen.", + "output": "Basophils.band form (Laboratory Procedure)" + }, + { + "input": "Definition: something described as COPD Assessment Test (CAT) (COPD Assessment Test and the CAT logo is a trade mark of the GlaxoSmithKline group of companie. Copyright 2009 GlaxoSmithKline group of companies. All rights reserved).", + "output": "Chronic obstructive pulmonary disease assessment test (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as the site in or on the body at which the laboratory test or result is performed or collected.", + "output": "Laboratory Test Results Location (Location)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 3q", + "output": "3q21 (Chromosome band)" + }, + { + "input": "Definition: Diagnostic Reagent described as a fluorinated derivative of the 2-nitroimidazole etanidazole. EF5 is effective in accessing oxygen levels in tumor tissue through its adduct formation to intracellular macromolecules in the absence of oxygen. Reduction of this agent is carried out by a diverse group of enzymes in the cytoplasm, microsomes and mitochondria. Tissue hypoxia detection via EF5 has been reported in several cancers, including squamous cell carcinoma of the cervix and the head and neck, and in sarcoma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C45873\" active clinical trials using this agent.", + "output": "EF5 (Organic Chemical)" + }, + { + "input": "Definition: Allergen class described as class of antidepressants with 3 ring chemical structures; mechanism unknown, but believed to involve serotonin metabolism, transport, or receptor sensitivity.", + "output": "tricyclic anti-depressants (Tricyclic Antidepressive Agents)" + }, + { + "input": "Definition: Conceptual Entity described as addition of extra material.", + "output": "Amplification (Phenomenon or Process)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Proxy - Participation in society in the past 30 days: How much of a problem did your relative have in doing things by himself or herself for relaxation or pleasure?", + "output": "WHODAS 2.0 36-item Version Proxy-administered - Problem Doing Things for Relaxation (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)" + }, + { + "input": "Definition: Lights, manufactured described as lights designed to provide intense, structured illumination on a surface or restricted area. These illumination lights convert electric power into emitted radiation typically in a wavelength range that includes the visible spectrum. These lights are available in several shapes and sizes and use various types of bulbs such as incandescent, compact fluorescent lamps (CFL), and light-emitting diodes (LED). They are available mounted in fixtures of a wide range of shapes and sizes in ceiling-mounted, stand-alone, wall-mounted, and handheld (i.e., portable) configurations; some have a fully articulating head that may be aimed precisely at the target. High-intensity illumination spotlights can be used for inspections in large areas and/or for long distance imaging applications.", + "output": "Lights, Illumination, High-Intensity, Spotlight (Lights, manufactured)" + }, + { + "input": "Definition: amide transport described as the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.", + "output": "methotrexate transport (amide transport)" + }, + { + "input": "Definition: something described as quality Of Life Enjoyment And Satisfaction Questionnaire - During the past week how much of the time have you: Felt good about your life?", + "output": "QLES124 (Intellectual Product)" + }, + { + "input": "Definition: Finding described as a disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity.", + "output": "Ascites, CTCAE (Gastrointestinal Disorders, CTCAE)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an immunoglobulin G1 (IgG1) bispecific human monoclonal antibody against human CD3, a T-cell surface antigen, and human C-type lectin domain family 12 member A (CLEC12A), a tumor-associated antigen (TAA) overexpressed on certain tumor cells, with potential antineoplastic activity. Upon administration, anti-CLEC12A/CD3 bispecific antibody MCLA117 binds to both CD3 on T cells and CLEC12A expressed on malignant cells, such as myeloid blasts, atypical progenitor cells and leukemic stem cells (LSCs). This results in the cross-linking of T cells with tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CLEC12A-expressing tumor cells. CLEC12A, a myeloid differentiation antigen and member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed on myeloid leukemia cells, but not on normal early hematopoietic progenitors, including hematopoietic stem cells (HSCs).", + "output": "Immunoglobulin G1, Bispecific, Anti-(C-type lectin CLEC12A and CD3 Antigen) (Human Monoclonal MCLA-117 Gamma1-chain), Disulfide with Human Monoclonal MCLA-117 Kappa-chain, Dimer (Immunologic Factor)" + }, + { + "input": "Definition: Mixed mineral dust pneumoconiosis described as an occupational lung disorder caused by the inhalation of silica dust. It results in the inflammation and scarring of the upper lobes of the lungs. It may be an acute or chronic disorder. In the acute form, patients develop shortness of breath, fever, and cyanosis. In the chronic form patients, develop progressive shortness of breath.", + "output": "Silicosis, NOS (Lung disease due to external agents)" + }, + { + "input": "Definition: Molecular Function described as preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.", + "output": "membrane curvature sensor activity (Lipid Binding)" + }, + { + "input": "Definition: something described as eukaryotic translation initiation factor 3 subunit E (445 aa, ~52 kDa) is encoded by the human EIF3E gene. This protein is involved in both translation initiation and nonsense mediated mRNA decay.", + "output": "Eukaryotic Translation Initiation Factor 3 Subunit E (Biologically Active Substance)" + }, + { + "input": "Definition: Gene or Genome described as trafficking Protein Genes encode proteins involved in various cellular sorting and transport mechanisms - such as gated transport, protein translocation, and vesicular transport - whereby cellular proteins are positioned, sorted, and directed to, sequestered in, or moved from one cellular compartment to another specific correct subcellular cellular compartment for proper function.", + "output": "Trafficking Protein Gene (Gene or Genome)" + }, + { + "input": "Definition: Trichothecenes described as the biotoxin T-2 toxin.", + "output": "t-2 toxin (Sesquiterpenes)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) Over the past 4 weeks, I have had shortness of breath.", + "output": "SGRQ Past 4 Weeks Version - I Have Had Shortness of Breath (Intellectual Product)" + }, + { + "input": "Definition: Benzodiazepine antiepileptic described as an anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.", + "output": "Clonazepam-containing product (Gamma-aminobutyric Acid (GABA) Augmenting Agents)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Pharyngeal mucositis (Pharyngeal Mucositis, CTCAE)" + }, + { + "input": "Definition: Form family Moniliaceae described as any fungal organism that is not assigned to the species level but can be assigned to the Paecilomyces genus level.", + "output": "paecilomyces (Mitosporic Fungi)" + }, + { + "input": "Definition: something described as a mass spectrometry method in which chemically purified samples are heated to create positively ionized atoms that are then accelerated by an electric field and mass separated by an electromagnet.", + "output": "Thermal Ionization Mass Spectrometry (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a group of mitochondrial DNA maintenance syndrome diseases with characteristics of predominantly neuromuscular manifestations with typically infantile onset of hypotonia, lactic acidosis, psychomotor delay, progressive hyperkinetic-dystonic movement disorders, external ophthalmoplegia, sensorineural hearing loss, seizures and variable renal tubular dysfunction. It may be associated with a broad range of other clinical features.", + "output": "Mitochondrial deoxyribonucleic acid depletion syndrome encephalomyopathic form (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: Food consistency types described as containing hard pieces, crust or skin which has formed during cooking/heating/standing. Crunchy, crispy, tough, or dry. Unable to mash with a fork. Hard to chew and swallow (Source: Academy of Nutrition and Dietetics Nutrition Informatics Committee 2013).", + "output": "Hard food (Food)" + }, + { + "input": "Definition: Malignant immunoproliferative disease described as a bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia.", + "output": "Cell Myelomas, Plasma (Paraproteinemias)" + }, + { + "input": "Definition: Negative Regulation of Apoptosis described as any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "output": "negative regulation of muscle cell apoptosis (Cell Function)" + }, + { + "input": "Definition: Medicinal product categorized by disposition described as any substance or agent which suppresses, prevents or opposes the action of xanthine oxidase.", + "output": "Xanthine oxidase inhibitor (Gout Suppressants)" + }, + { + "input": "Definition: Superficial vein of face described as tributary of fecial vein, each instance of which that follows some submental artery and drains some submandibular and sublingual glands, mylohyoid muscle, and skin in the submental area.", + "output": "Structure of submental vein (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Medical Device described as a penile rigidity implant is a device that consists of a single semi-rigid rod or a pair of semi-rigid rods implanted in the penis to provide rigidity. It is used in the treatment of erectile impotence.", + "output": "Penile Prostheses, Rod (Penile Prosthesis)" + }, + { + "input": "Definition: something described as this gene is involved in steroid metabolism.", + "output": "CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Cytochrome P450 Family Gene)" + }, + { + "input": "Definition: something described as a rare form of pontocerebellar hypoplasia with characteristics at birth of hypotonia, clonus, epilepsy, impaired swallowing and from infancy progressive microcephaly, spasticity and lactic acidosis. Reported in less than 10 cases to date. Caused by missense and splice site mutations in the mitochondrial arginyl-transfer RNA synthetase (RARS2) gene located to 6q16.1. Prognosis is poor, exact life expectancy is unknown but in most cases does not exceed infancy.", + "output": "Congenital pontocerebellar hypoplasia type 6 (Congenital pontocerebellar hypoplasia)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in genes associated with oculocutaneous albinism, a form of albinism in which pigmentation of the hair, skin, and eyes is affected. Genetic variants at multiple loci have been associated with oculocutaneous albinism. These reagents are intended to detect mutations in multiple oculocutaneous albinism-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Metabolic Disorder, Albinism, Oculocutaneous, Mutation (IVD Panels, Human Genetics, Metabolic Disorder, Albinism, Oculocutaneous)" + }, + { + "input": "Definition: Plant or Plant Part Extract described as an oral tablet containing an extract of the plant Salvia officinalis (common sage) with reported antihydrotic, antibiotic, antihypertensive, anti-inflammatory, antioxidant, astringent, antispasmodic, estrogenic, and hypoglycemic properties. The primary biologically active component of common sage appears to be its essential oil which contains mainly cineol, borneol, and alpha- and beta-thujone. In addition, sage leaf contains numerous other substances including tannic acid; resins with oleic, ursonic, and ursolic acids; bitter substances with cornsole and cornsolic acid; fumaric, chlorogenic, caffeic and nicotinic acids; nicotinamide; flavones; flavone glycosides; and estrogenic substances. However, the mechanism(s) of action of common sage in the treatment of various disorders is unclear.", + "output": "Common Sage Extract (Organic Chemical)" + }, + { + "input": "Definition: Abnormality of metabolism/homeostasis described as an altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme.", + "output": "Abnormal enzyme/coenzyme activity (Abnormality of metabolism/homeostasis)" + }, + { + "input": "Definition: Beta radiation described as beta radiation produced by the decay of strontium-90.", + "output": "Strontium-90 Beta Radiation (Beta radiation)" + }, + { + "input": "Definition: Intellectual Product described as north Star Ambulatory Assessment - Time to run as fast as you can (seconds).", + "output": "NSAA117A (NSAA Clinical Classification Question)" + }, + { + "input": "Definition: something described as potential usefulness of an individual as judged on the basis of job skills, functional literacy, emotional or social maturity, intellectual development, or personal values (e.g., personal responsibility).", + "output": "Employability (Qualitative Concept)" + }, + { + "input": "Definition: Passive biological transport described as the directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "carbon dioxide transport (carbon dioxide)" + }, + { + "input": "Definition: something described as urethral cancer with a finding of carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion.", + "output": "Prostatic Urethra Carcinoma pTis TNM Finding v8 (Prostatic Urethra Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: negative regulation of cartilage development described as any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation.", + "output": "negative regulation of cartilage condensation (negative regulation of cartilage development)" + }, + { + "input": "Definition: Finding described as present", + "output": "Grade 1 Rhinorrhea, CTCAE (Rhinorrhea, CTCAE)" + }, + { + "input": "Definition: Gastro-enteropancreatic neuroendocrine tumor described as a term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.", + "output": "Digestive System Neuroendocrine Neoplasm by AJCC v7 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Vascular Diseases described as general term for blockage of blood flow through arteries or veins; do not confuse with the blockages that are used with therapeutic intent for this use THERAPEUTIC BLOOD VESSEL OCCLUSION.", + "output": "vascular obstruction (Disease or Syndrome)" + }, + { + "input": "Definition: something described as leakage due to breakdown of a pancreatic anastomosis.", + "output": "Pancreatic Anastomotic Leakage (Pathologic Function)" + }, + { + "input": "Definition: Uterine Corpus Carcinoma and Carcinosarcoma Clinical TNM Finding v8 described as a clinical finding about one or more characteristics of uterine corpus carcinoma or carcinosarcoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.", + "output": "Uterine Corpus Carcinoma and Carcinosarcoma Clinical Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Information Systems, Data Management, Financial described as data management information systems designed to manage patient insurance verification, gathering important demographic information, financial requirement review, and co-pay collection. These systems typically consist of a combination of hardware and software. The hardware typically includes dedicated network servers and computers; the software consists of a dedicated software package that ensures that the patient carries proper insurance, facilitating a quick and accurate reimbursement process as requirements are verified before treatment is administered. Registration financial information data management systems may function as stand-alone systems or may be integrated in a hospital-wide financial data management information system network.", + "output": "Information Systems, Data Management, Financial, Registration (Information Systems, Data Management, Financial)" + }, + { + "input": "Definition: Lesion of iris described as tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.", + "output": "Iris Neoplasms (Neoplasm of uveal tract)" + }, + { + "input": "Definition: Pharmacologic Substance described as a preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity. T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation. EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62784\" active clinical trials using this agent.", + "output": "LMP2A-CTL (Cell)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cryptochrome-1 (586 aa, ~66 kDa) is encoded by the human CRY1 gene. This protein plays a role in the circadian rhythm process.", + "output": "cryptochrome 1 (Biologically Active Substance)" + }, + { + "input": "Definition: TNM classification of malignant tumor before any treatment described as a distant metastasis TNM finding indicating that the status of distant metastasis cannot be assessed.", + "output": "MX TNM Finding (Generic Distant Metastasis TNM Finding)" + }, + { + "input": "Definition: Molecular Function described as voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.", + "output": "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential (voltage-gated ion channel activity)" + }, + { + "input": "Definition: Sponsor ID described as one or more sponsor defined characters used to identify, name, or characterize the respiratory system findings.", + "output": "Respiratory System Findings Sponsor Defined Identifier (Sponsor ID)" + }, + { + "input": "Definition: Cell Component described as the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.", + "output": "synapse-associated extracellular matrix (Cell Component)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and antineoplastic activities. Administered via intramuscular electroporation, HPV DNA plasmids therapeutic vaccine VGX-3100 expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved in cervical carcinogenesis.", + "output": "HPV DNA plasmids therapeutic vaccine VGX-3100 (Vaccines, DNA)" + }, + { + "input": "Definition: response to ketone described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus.", + "output": "response to curcumin (response to antineoplastic agent)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the CTNNB1 gene.", + "output": "Beta Catenin Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as surgical instrument motors and accessories are AC-powered, battery-powered, or air-powered devices intended for use during surgical procedures to provide power to operate various accessories or attachments to cut hard tissue or bone and soft tissue. Accessories or attachments may include a bur, chisel (osteotome), dermabrasion brush, dermatome, drill bit, hammerhead, pin driver, and saw blade.", + "output": "BIT, SURGICAL (Medical Device)" + }, + { + "input": "Definition: something described as coronary Thrombus TIMI Grade - Grade corresponding to thrombus development as defined in the grading system by the Thrombolysis in the Myocardial Infarction Group.", + "output": "TIMG0101 (TIMI Thrombus Grade Clinical Classification Question)" + }, + { + "input": "Definition: something described as the distal portion of the rectum that converges with the anal canal.", + "output": "Colorectal Zone of the Anal Canal (Digestive System Part)" + }, + { + "input": "Definition: something described as actinidia deliciosa (A. Chev.) C. F. Liang & A. R. Ferguson = Actinidia chinensis P.", + "output": "kiwifruit (Plant)" + }, + { + "input": "Definition: Disease or Syndrome described as excessive growth of keratin on the skin.", + "output": "keratoses (Skin lesion)" + }, + { + "input": "Definition: Medical Device described as the acquisition of images of an anatomic area that is being irradiated using radiotherapy beams and films as imaging media.", + "output": "Film Portal Imaging (Medical Device)" + }, + { + "input": "Definition: Finding described as a tram-track sign is composed of two enhancing areas of tumor separated from each other by the negative defect of the optic nerve. It is seen on contrast-enhanced CT scan and MRI images, in optic nerve sheath meningioma. The sign helps distinguish between optic nerve sheath meningioma and optic glioma. Optic glioma arises from glial cells within the optic nerve and there is no clear separation between the nerve and the tumor; hence the tram-track sign is not seen in optic gliomas. Calcification may be seen in optic nerve sheath meningiomas in 20-50% of cases and hence the tram-track sign may be seen on nonenhanced CT scan images as a linear calcification around the nerve, but this is less common.", + "output": "Optic nerve tram-track sign (Finding)" + }, + { + "input": "Definition: Finding described as pelvis cancer with tumor spanning two pelvic segments with extraosseous extension.", + "output": "Pelvis Cancer pT3 TNM Finding v8 (Pelvis Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Neoplastic Process described as a condition in which a higher-than-normal number of identical B cells are found in the blood. People with MBL may develop other B-cell diseases, such as chronic lymphocytic leukemia (CLL).", + "output": "MBL - monoclonal B-cell lymphocytosis (Lymphocytosis)" + }, + { + "input": "Definition: Hepatic Infection, CTCAE described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated", + "output": "Grade 3 Hepatic Infection, CTCAE (Finding)" + }, + { + "input": "Definition: cell differentiation involved in metanephros development described as the process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state.", + "output": "metanephric interstitial fibroblast differentiation (cell differentiation involved in metanephros development)" + }, + { + "input": "Definition: Disease or Syndrome described as a muscular dystrophy that was caused by a primary mitochondrial disorder.", + "output": "Muscular Dystrophy Secondary to Mitochondrial Disorder (Other Finding)" + }, + { + "input": "Definition: Lycopodiales described as the club-moss plant family of the order Lycopodiales, class Lycopodiopsida, division Lycopodiophyta, subkingdom TRACHEOPHYTA. The common name of clubmoss applies to several genera of this family. Despite the name this is not one of the true mosses (BRYOPSIDA ).", + "output": "Club Moss (Plant)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the pro-platelet basic protein in a biological specimen.", + "output": "NAP-2 (Laboratory Procedure)" + }, + { + "input": "Definition: Graft vs Host Reaction described as a disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes.", + "output": "gvhd (manifestations of immunopathology)" + }, + { + "input": "Definition: something described as enables the transfer of auxin, from one side of a membrane to the other, out of a cell.", + "output": "auxin efflux transmembrane transporter activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury.", + "output": "Neuropathic Pain (Finding)" + }, + { + "input": "Definition: New client home-visit with ICD diagnosis described as evaluating and managing a new client in a usual, 20-minute home-visit. This code may be used by providers of services who are able to diagnose.", + "output": "new hmvst 20min (New client home-visit with ICD diagnosis)" + }, + { + "input": "Definition: inositol trisphosphate phosphatase activity described as catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.", + "output": "inositol-1,3,4-trisphosphate 4-phosphatase activity (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as single-minded homolog 1 (766 aa, ~86 kDa) is encoded by the human SIM1 gene. This protein is involved in transcriptional regulation and embryonic development.", + "output": "Single-Minded Homolog 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: chloroplast relocation described as the relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis.", + "output": "chloroplast accumulation movement (Cell Function)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly.", + "output": "positive regulation of neurofibrillary tangle assembly (regulation of neurofibrillary tangle assembly)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as all or a portion of a composite structure that includes the supracallosal gyrus and the paraterminal gyrus. See Anthoney-1994 for a review of different uses of this term.", + "output": "hippocampal rudiment (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Yao language - Bantu described as a Niger-Congo Bantu language spoken by the Shona people of Zimbabwe.", + "output": "Shona Language (Yao language - Bantu)" + }, + { + "input": "Definition: Cell Function described as the aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.", + "output": "interphase microtubule organising center formation (microtubule organizing center organization)" + }, + { + "input": "Definition: Plant described as a plant genus of the family ASTERACEAE.", + "output": "Cynara L., 1753 (Plant)" + }, + { + "input": "Definition: something described as serous sac which consists of a synovial membrane surrounding the synovial cavity. Examples: synovial bursa, synovial tendon sheath of index finger, synovial capsule of knee joint.", + "output": "Synovial sac (Serous sac)" + }, + { + "input": "Definition: Blood isoimmune reactions described as a condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against Rhesus blood group system antigens, which include C, c, D, E, and e.", + "output": "Erythroblastosis Fetalis, Rh Disease (Neonatal blood incompatibility disorders)" + }, + { + "input": "Definition: Wellness and Lifestyle described as the activities of taking in, assimilating, and using nutrients for the purposes of tissue maintenance, tissue repair, and the production of energy", + "output": "NUTRITION (Wellness and Lifestyle)" + }, + { + "input": "Definition: response to peptide hormone described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response.", + "output": "response to CRH stimulus (Cell Function)" + }, + { + "input": "Definition: something described as a classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.", + "output": "Salt-Wasting 21-Hydroxylase Deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the analysis is specified in a protocol.", + "output": "Analysis Specified in Protocol (Qualitative Concept)" + }, + { + "input": "Definition: Animals, Inbred Strains described as genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.", + "output": "Strains, Inbred Mouse (Mus)" + }, + { + "input": "Definition: something described as a primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes.", + "output": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage (Cell)" + }, + { + "input": "Definition: Plant described as plants that can grow well in soils that have a high SALINITY.", + "output": "Plants, Salt Tolerant (Plant)" + }, + { + "input": "Definition: something described as microwave surgical units that use a device linking a microwave radiator to a scalpel. These units consist of a microwave generator typically of 150-to-200 watt energy and 2.45 GHz frequency, a coaxial cable to transmit the energy to the handle of the scalpel and a surgical scalpel that includes a small-loop antenna in the blade. Scalpel microwave surgical units are used in surgery of the liver and spleen.", + "output": "Microwave Surgical Units, Scalpel (Microwave Surgical Units)" + }, + { + "input": "Definition: Altered sensation of skin described as absent or reduced sensitivity to cutaneous stimulation.", + "output": "HYPOAESTHESIA (Dysesthesia)" + }, + { + "input": "Definition: Other disorders affecting eyelid function described as the abnormal narrowness of the palpebral fissure in the horizontal direction caused by the lateral displacement of the medial canthi of the eyelids.", + "output": "Blepharophimoses (inspection of palpebral fissures)" + }, + { + "input": "Definition: Classification described as a classification system for the endoscopic assessment of reflux esophagitis based on the number and extent of mucosal breaks and their relationships to the mucosal folds and esophageal circumference.", + "output": "Los Angeles Classification System for endoscopic assessment of reflux esophagitis (Classification)" + }, + { + "input": "Definition: Character Result or Finding in Standard Format described as the standard character or string for representation and reporting of cardiovascular system findings data.", + "output": "CVSTRESC (Intellectual Product)" + }, + { + "input": "Definition: Regulatory Pathway described as many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated transcriptional control of proliferation in specific developmental cell types is crucial in multiple developmental settings. One of a family of three bicoid-related transcription factors, Pitx2 acts downstream of the extracellular signaling protein Wnt to drive proliferation of cells with specific developmental fates, including cells in the pituitary, cardiac outflow region, and muscle. Wnt binds to Frizzled, a G-protein coupled receptor, activating homologs of the Drosophila Disheveled protein. Activation of Frizzled and Disheveled inhibits the kinase GSK-3 beta, part of a protein complex in the absence of Wnt signaling, causing beta-catenin protein to accumulate in the cytoplasm. Beta-catenin is known to alter the function of transcription factors like TCF/Lef. One result of Wnt signaling is activation of the transcription factor Lef by beta-catenin, inducing Pitx2 expression. Wnt activation also changes Pitx2 from a repressor to an activator by causing transcriptional corepressors like histone deacetylase 1 (HDAC1) bound to Pitx2 to be exchanged for coactivators. With coactivators bound, Pitx2 activates transcription of genes that regulate the cell cycle, such as Cyclin D2. Different coactivators are recruited by Pitx2 and other transcription factors like Myc to the Cyclin D2 promoter, with CBP/p300 recruited first, followed by NLI/Ldb/CLIM, Tip60/TRRAP, and PBP coactivators. Many of these coactivators help to alter histone acetylation and chromatin structure as part of transcriptional activation. The activation of cell cycle genes by Pitx2 ultimately stimulates the proliferation of specific cell types with the confluence of tissue-specific gene expression, growth factor signaling and coactivator recruitment.", + "output": "Pitx2 Transcription Regulation Pathway (Regulatory Pathway)" + }, + { + "input": "Definition: something described as family of one electron transfer reaction mediators and catalysts whose reactive moiety consists of a cluster of iron and inorganic sulfide liganded to cysteine SH groups.", + "output": "iron sulfur protein (Iron Compounds, Organic)" + }, + { + "input": "Definition: Dental Route of Drug Administration described as administration of a substance within the tissues surrounding a tooth or teeth.", + "output": "PERIODONTAL (Functional Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as a focal cognitive seizure characterized by neglect as the initial semiological manifestation.", + "output": "Focal cognitive seizure with neglect (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a calendar date specifying the end of the clinical site participation in a particular study", + "output": "End Date of Clinical Study Site Participation in Study (Temporal Concept)" + }, + { + "input": "Definition: Poisoning syndrome described as poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.", + "output": "poisoning; mushrooms (Chemical food poisoning)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as lamina-associated polypeptide 2, isoforms beta/gamma (694 aa, ~75 kDa) is encoded by the human TMPO gene. This protein is involved in the mediation of nuclear structure.", + "output": "TPRP Isoforms Beta/Gamma (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD(+) <=> 5'-oxoaverantin + NADH.", + "output": "5'-hydroxyaverantin dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: something described as kidney cancer in which the primary tumor cannot be assessed.", + "output": "pTX Renal Carcinoma (Finding)" + }, + { + "input": "Definition: something described as the alapivalate ester prodrug form of ceftizoxime, a semi-synthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. After oral administration of ceftizoxime alapivoxil, the ester bond is cleaved, releasing active ceftizoxime.", + "output": "Ceftizoxime Alapivoxil (Cephalosporins)" + }, + { + "input": "Definition: ameboidal-type cell migration described as cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.", + "output": "fibroblast migration (Cell Function)" + }, + { + "input": "Definition: something described as human FZD3 wild-type allele is located within 8p21 and is approximately 70 kb in length. This allele, which encodes frizzled-3 protein, plays a role in signal transduction processes in the beta-catenin canonical signaling pathway.", + "output": "Frizzled 3 Gene (FZD3 gene)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Children (TSCC) Trying not to have any feelings.", + "output": "TSCC01-Trying Not to Have Any Feelings (Intellectual Product)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the ceroid-lipofuscinosis, neuronal 1(CLN1) gene, located at chromosome 1p32, which encodes for nonspecific lysosomal peptidase that generates tripeptides. Mutations at this locus have been identified in patients with neuronal ceroid-lipofuscinoses (NCL) diseases.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CLN1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Initial/first attempt potential lethality.", + "output": "CSS0524C (Intellectual Product)" + }, + { + "input": "Definition: Group ID described as a character or string that represents a laboratory test group.", + "output": "LBGRPID (Group ID)" + }, + { + "input": "Definition: melanoma described as a rare aggressive neoplastic disease with the presence of a melanocyte neoplasm that develops in any mucosal membrane. Clinical manifestations vary depending on the site of occurrence.", + "output": "Malignant melanoma of mucous membrane (melanoma)" + }, + { + "input": "Definition: Tetrahymenina described as genus in the order Hymenostomatida; ciliate protozoa commonly used in genetic, cytological and other research.", + "output": "Tetrahymena (Tetrahymenidae)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the fukutin related protein (FKRP) gene, located at chromosome 19q13.32, which encodes the protein fukutin-related protein. Genetic variants at this locus have been associated with congenital muscular dystrophy-dystroglycanopathy.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, FKRP (Medical Device)" + }, + { + "input": "Definition: Research Activity described as advancement of propositions and formulation of hypotheses concerning description, explanation, or interpretation of facts. Applies both to principles of theory formulation and presentation of new theories.", + "output": "Theory Formulation (Research Activity)" + }, + { + "input": "Definition: Medical Device described as an instrument that combines the use of a focused beam of gallium ions to etch or coat a sample with a scanning electron microscope to image the sample.", + "output": "Focused Ion Beam-Scanning Electron Microscope (Microscopes, Electron, Scanning)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.", + "output": "RECEPT TUMOR NECROSIS FACTOR (Receptor)" + }, + { + "input": "Definition: Intrinsic drive described as process of adjusting one's behavior to achieve or avoid a particular outcome.", + "output": "self-regulation (Social Behavior)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - If yes, which best describes {S} usual degree of participation.", + "output": "ADL02-Usual Conversation Participation (Intellectual Product)" + }, + { + "input": "Definition: Malignant neoplasm of abdomen described as a complete hydatidiform mole or very rarely a partial mole that invades the myometrium.", + "output": "malignant moles (Gestational Trophoblastic Neoplasms)" + }, + { + "input": "Definition: something described as tuberculosis disease that is caused by a multidrug-resistant strain of Mycobacterium tuberculosis.", + "output": "multi-drug-resistant tuberculosis (Tuberculosis, Drug-Resistant)" + }, + { + "input": "Definition: Medical Device described as a nonelectrically powered fluid injector is a nonelectrically powered device used by a health care provider to give a hypodermic injection by means of a narrow, high velocity jet of fluid which can penetrate the surface of the skin and deliver the fluid to the body. It may be used for mass inoculations.", + "output": "INJECTOR, FLUID, NON-ELECTRICALLY POWERED (Medical Device)" + }, + { + "input": "Definition: something described as a group of disorders characterized by physiological and psychological disturbances in appetite or food intake.", + "output": "Feeding and eating disorders (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Fungi, Parasites, Insects and Animals described as a phylum of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.", + "output": "Secernentea (Animals)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in development and spermatogenesis.", + "output": "KFGF (Fibroblast Growth Factor Gene Family)" + }, + { + "input": "Definition: Disaccharides described as a nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.", + "output": "Table sugar (Carbohydrates)" + }, + { + "input": "Definition: something described as a newborn reflex that is characterized by flexion of the toes when the sole of the foot is stroked.", + "output": "Plantar Grasp Reflex (Finding)" + }, + { + "input": "Definition: COXEN Sensitivity Scale described as a score of 19 on the COXEN Sensitivity Scale.", + "output": "COXEN Score 19 (Finding)" + }, + { + "input": "Definition: drug response described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.", + "output": "response to MPH (drug response)" + }, + { + "input": "Definition: something described as a subdivision of the frontal lobe of the guenon defined on the basis of cytoarchitecture. Brodmann-1909 did not regard it as cytoarchitecturally homologous to his area 10 of Brodmann (human). \\r\\nDistinctive features ( Brodmann-1905 ): compared to area 9 of Brodmann (guenon), the multiform layer (VI) of area 10 shows an unusual organization of cells into trains oriented parallel to the cortical surface that are separated from one another by narrow cell-free fiber bundles; less marked differences are an overall thinner cortical thickness and a somewhat thicker molecular layer of the cerebellar cortex (I). Compared to area 6 of Brodmann (guenon), area 10 has a subtle but clearly present internal granular layer (IV); layer 3b of the of the external pyramidal layer (III) is weakly developed and composed of medium sized pyramidal cells; and the internal pyramidal layer (V) is more developed.", + "output": "10 (Body Location or Region)" + }, + { + "input": "Definition: something described as a Semitic language spoken as a first language by the Amharas ethnic group and which serves as the official working language of Ethiopia.", + "output": "Amharic (Ethiopic language)" + }, + { + "input": "Definition: something described as an autosomal recessive disorder caused by mutation of the AK1 gene. It is associated with moderate to severe non-spherocytic hemolytic anemia and, in some cases, with intellectual disability and psychomotor impairment.", + "output": "Red Cell Adenylate Kinase Deficiency (Anemia due to Erythrocyte Enzyme Disorder)" + }, + { + "input": "Definition: Kinase Family Gene described as this gene is involved in the metabolism of nucleosides, nucleotides and nucleic acids in the cytosol.", + "output": "TK1 (Kinase Family Gene)" + }, + { + "input": "Definition: Organ or Tissue Function described as pulse oximetry utilising near infrared spectroscopy (NIRS) is commonly used in modern ICUs to provide a continuous measure of haemoglobin saturation and systemic oxygenation.", + "output": "Cerebral oxygen saturation (Hemoglobin saturation with oxygen)" + }, + { + "input": "Definition: Diagnostic Techniques, Cardiovascular described as method of non-invasive, continuous measurement of microcirculation based on the values of the Doppler effect of low-power laser light scattered randomly by static structures and moving tissue particulates.", + "output": "Laser doppler flowmetry (Vascular imaging procedures NEC)" + }, + { + "input": "Definition: something described as the date (and time) span for when the research organization is active. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "ResearchOrganization.effectiveDateRange (Temporal Concept)" + }, + { + "input": "Definition: something described as one of three central gray columns of the spinal cord. It is composed of lamina VIII and lamina IX ( Schiebler-1999 ). The other columns are the lateral gray column and the posterior gray column. Because of its appearance in cross section it is also called the anterior or ventral horn ( Carpenter-1983 ). In addition to the human it is found in the macaque ( NeuroNames ), rat ( Swanson-2004 ) and mouse ( Hof-2000 ). Functionally it is a major component of the somatic motoneuron pools of the subcortical motor system ( Swanson-2004 ).", + "output": "Cornu anterius (Spinal cord grey matter structure)" + }, + { + "input": "Definition: Pregnanes described as an anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.", + "output": "Cyproterone-containing product (Antineoplastic Agents)" + }, + { + "input": "Definition: Regimen Used to Treat Childhood Rhabdomyosarcoma described as a regimen consisting of ifosfamide and doxorubicin used for the treatment of high-risk childhood rhabdomyosarcoma.", + "output": "ID Regimen (Regimen Used to Treat Childhood Rhabdomyosarcoma)" + }, + { + "input": "Definition: Homeopathic remedies letter H described as golden seal root.", + "output": "Hydrastis canadensis, homeopathic preparation (Homeopathic remedies letter H)" + }, + { + "input": "Definition: Pharmacologic Substance described as endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.", + "output": "5 HT2 Agonists (Pharmacologic Substance)" + }, + { + "input": "Definition: Diseases described as a collective term for diseases of the skin and its appendages and of connective tissue.", + "output": "SKIN CONNECTIVE TISSUE DIS (Latvian translation of the Medical Subject Headings)" + }, + { + "input": "Definition: Disease or Syndrome described as genetically determined disorders of the reabsorptive functions of the kidney with regard to specific nephron segments responsible for specific transport functions, classifiable by proximal nephron function, loop of Henle function, and distal nephron function; transport defects can be selective or nonselective.", + "output": "Renal Tubular Transport, Inborn Error (Genetic Diseases, Inborn)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as protein kinase C delta type (676 aa, ~78 kDa) is encoded by the human PRKCD gene. This protein plays a role in the regulation of apoptosis.", + "output": "Protein Kinase C Delta Type (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as stones in the URINARY BLADDER; also known as vesical calculi, bladder stones, or cystoliths.", + "output": "bladder; calculus (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, desflurane, administered by inhalation, appears to act on the lipid matrix of the neuronal membrane, resulting in disruption of neuronal transmission in the brain. This agent may also enhance the synaptic activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).", + "output": "1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane (General Anesthetic [EPC])" + }, + { + "input": "Definition: Retroviridae Proteins, Oncogenic described as an oncoprotein from the Cas NS-1 murine retrovirus that induces pre- B-CELL LYMPHOMA and MYELOID LEUKEMIAS. v-cbl protein is a tyrosine-phosphorylated, truncated form of its cellular homologue, PROTO-ONCOGENE PROTEIN C-CBL.", + "output": "cbl Oncogene Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Medical Device described as an endolymphatic shunt is a device that consists of a tube or sheet intended to be implanted to relieve the symptons of vertigo. The device permits the unrestricted flow of excess endolymph from the distended end of the endolymphatic system into the mastoid cavity where resorption occurs. This device is made of polytetrafluoroethylene or silicone elastomer.", + "output": "TUBE, SHUNT, ENDOLYMPHATIC (Medical Device)" + }, + { + "input": "Definition: Monosaccharides described as monosaccharide molecules that contain a three carbon backbone.", + "output": "Three Carbon Monosaccharides (Monosaccharides)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Patient Global Impression Generic Modification Version (PGI Generic Modification Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "PGI01TN (Intellectual Product)" + }, + { + "input": "Definition: something described as disorder with characteristics of recurrent seizures, encephalopathy, and intellectual disability with typical onset in infancy. In most cases, seizures cease by age one, however the other neurological symptoms persist. The most common seizures are infantile spasms, however other seizure types associated with this disease include myoclonic seizures, atonic seizures, absence seizures, tonic-clonic seizures. Most individuals have more than one type of seizure and they may be refractory. Caused by mutations in the STXBP1 gene. STXBP1 gene mutations reduce the amount of functional protein produced which impairs the release of neurotransmitters from neurons, a change in levels may result in seizures. Inherited in an autosomal dominant pattern however most cases result from de novo mutations.", + "output": "STXBP1 (syntaxin binding protein 1) epileptic encephalopathy (X-linked infantile spasms)" + }, + { + "input": "Definition: Minerals described as a metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.", + "output": "mg (Element or Ion)" + }, + { + "input": "Definition: Lymphoma stage described as an anatomic stage for Hodgkin and non-Hodgkin lymphomas based on the Ann Arbor classification criteria.", + "output": "Lymphoma by Ann Arbor Stage (Neoplastic Process)" + }, + { + "input": "Definition: TGFBR2 gene described as human TGFBR2 wild-type allele is located within 3p22 and is approximately 88 kb in length. This allele, which encodes TGF-beta receptor type-2 protein, plays a role in transcriptional regulation and cellular proliferation control. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.", + "output": "HNPCC6 (TGFBR2 gene)" + }, + { + "input": "Definition: something described as suicidal Ideation Questionnaire - I thought that if I killed myself people would realize I was worth caring about.", + "output": "SIQ0125 (SIQ Questionnaire Question)" + }, + { + "input": "Definition: Mass of female genital structure described as an uncommon benign lesion in the vulva. It manifests with multiple papular lesions which are purple in color. They are usually asymptomatic. Histologically, there is hyperkeratosis, papillomatosis, and dilated blood vessels in the papillary dermis.", + "output": "Vulvar Angiokeratoma (Mass of vulva)" + }, + { + "input": "Definition: cellulose catabolic process described as the chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen.", + "output": "anaerobic cellulose degradation (cellulose catabolic process)" + }, + { + "input": "Definition: Apical anterior fibromuscular stroma of prostate described as the portion of the fibromuscular stroma of the prostate that is located on the anatomical right side of the apical division of the anterior lobe.", + "output": "Structure of apical part of anterior fibromuscular stroma of right half prostate (Fibromuscular Stroma of Prostate)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90548\" active clinical trials using this agent.", + "output": "sapanisertib (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Electrocardiography described as a method of fetal ECG surveillance during labor that monitors the ST segment, to indicate any fetal hypoxia.", + "output": "STAN (Electrocardiography)" + }, + { + "input": "Definition: dendrite morphogenesis described as the process in which the anatomical structures of an apical dendrite are generated and organized.", + "output": "apical dendrite morphogenesis (dendrite morphogenesis)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of nigerotriose transport.", + "output": "regulation of nigerotriose transport (Cell Function)" + }, + { + "input": "Definition: something described as (a) Pedicle screw spinal systems are multiple component devices, made from a variety of materials, including alloys such as 316L stainless steel, 316LVM stainless steel, 22Cr-13Ni-5Mn stainless steel, Ti-6Al-4V, and unalloyed titanium, that allows the surgeon to build an implant system to fit the patient's anatomical and physiological requirements. Such a spinal implant assembly consists of a combination of anchors (e.g., bolts, hooks, and/or screws); interconnection mechanisms incorporating nuts, screws, sleeves, or bolts; longitudinal members (e.g., plates, rods, and/or plate/rod combinations); and/or transverse connectors. The devices are intended to provide immobilization and stabilization of spinal segments in skeletally mature patients as an adjunct to fusion in the treatment of the following acute and chronic instabilities or", + "output": "ORTHOSIS, SPONDYLOISTHESIS SPINAL FIXATION (Medical Device)" + }, + { + "input": "Definition: glucosamine described as the N-acetyl derivative of glucosamine.", + "output": "N Acetyl D Glucosamine (Simple organic compound)" + }, + { + "input": "Definition: Stage I Pancreatic Cancer AJCC v6 and v7 described as stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IB Exocrine and Endocrine Pancreatic Cancer AJCC v6 and v7 (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Rest Tremor Amplitude Left Lower Extremity.", + "output": "UPD2317D (MDS-UPDRS Questionnaire Question)" + }, + { + "input": "Definition: Male external genitalia structure described as a condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.", + "output": "Phimosis (Male external genitalia structure)" + }, + { + "input": "Definition: Stage I Testicular Cancer AJCC v6 and v7 described as stage I includes: pT1-4, N0, M0, SX. pT1: Tumor limited to the testis and epididymis without vascular/lymphatic invasion; tumor may invade into the tunica albuginea but not the tunica vaginalis. pT2: Tumor limited to the testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis. pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion. pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. SX: Marker studies not available or not performed.", + "output": "Stage I Testicular Non-Seminomatous Germ Cell Tumor AJCC v6 (Neoplastic Process)" + }, + { + "input": "Definition: Killip Class described as the presence of rales over 50% or less of the lung fields or the presence of a third heart sound (S3).", + "output": "Killip Class II (Killip Class)" + }, + { + "input": "Definition: Viral Vaccines described as vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.", + "output": "rotavirus vaccine, unspecified formulation (Immunologic Factor)" + }, + { + "input": "Definition: Cephalosporins described as an Z-isomer of a semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation.", + "output": "Cefprozil, Z-Isomer (Antibiotic)" + }, + { + "input": "Definition: Clinical Observation described as an indication that an individual used something prior to their baseline visit.", + "output": "Use Before Visit (Finding)" + }, + { + "input": "Definition: something described as a focus of thrombus adhered to the wall of a fetal stem vessel. It can be completely or partially obstructive and may lead to downstream villous injury and calcification.", + "output": "Fetal Stem Vessel Thrombus with or without Dystrophic Calcification (Finding)" + }, + { + "input": "Definition: Catheters, Cardiac, Angiography described as angiographic cardiac catheters that include specific tip configurations to enter the cardiac chambers (e.g., left or right ventricle). Their distal tip may have an end hole and/or several side holes. Typical injection rates are medium or high (e.g., 5 to 65 mL/sec). Most of these catheters are introduced into either the femoral or the brachial artery; the distal tip is placed in the left or right ventricle as necessary. Left ventriculography is needed more frequently and is used to establish the degree of functional impairment of the left ventricle, the presence of ventricular aneurysms or ventricular septal defects, and to assess the mitral valve. Right ventriculography is mostly used for assessing congenital heart disease.", + "output": "Lehman Ventricular Catheters (Medical Device)" + }, + { + "input": "Definition: NSAA Clinical Classification Question described as north Star Ambulatory Assessment (NSAA) Can you step down from the box using your right leg first?", + "output": "NSAA - Descend Box Step - Right (NSAA Clinical Classification Question)" + }, + { + "input": "Definition: Neoplastic Process described as cancer that forms in a bile duct. A bile duct is a tube that carries bile (fluid made by the liver that helps digest fat) between the liver and gallbladder and the intestine. Bile ducts include the common hepatic, cystic, and common bile ducts. Bile duct cancer may be found inside the liver (intrahepatic) or outside the liver (extrahepatic).", + "output": "Bile Duct Carcinoma (Gastrointestinal system)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the retinoschisin 1 (RS1) gene, located at chromosome Xp22.2-p22.1, which encodes for a secreted protein crucial to the cellular organization of the retina. This genetic mutation has been identified in patients with X-linked inherited juvenile retinoschisis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RS1 (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Baseline (C-SSRS Baseline) Total number of actual attempts.", + "output": "C-SSRS Baseline - Number of Actual Suicide Attempts (Intellectual Product)" + }, + { + "input": "Definition: Finding described as a fold change based on the concentration of a specific drug expected to produce 50 percent inhibition of the population growth or replication of a microbial organism; it is a ratio calculated by the EC50 Subject Result divided by the EC50 Reference Control Result.", + "output": "Microbial EC50 Fold Change from Reference (Laboratory test finding)" + }, + { + "input": "Definition: nucleobase-containing compound transport described as the directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "output": "nucleic acid transport (Cell Function)" + }, + { + "input": "Definition: Gene or Genome described as human HOXA10 wild-type allele is located within 7p15-p14 and is approximately 10 kb in length. This allele, which encodes homeobox protein Hox-A10, is involved in both the modulation of the transcriptional activity of RNA Polymerase II and the development of the anterio-posterior axis.", + "output": "Homeobox A10 (HOXA10 gene)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of thyroid antibodies present in a sample.", + "output": "Thyroid Antibodies (Immunologic Tests)" + }, + { + "input": "Definition: Occupation or Discipline described as a class of professional or vocational positions of employment that involve life, physical or social sciences.", + "output": "Life, Physical, and Social Science Occupations (Occupation or Discipline)" + }, + { + "input": "Definition: Structure of intestinal lymph node described as superior mesenteric lymph node group which is located along ileocolic artery.", + "output": "Ileocolic lymph node group (Structure of colic lymph node)" + }, + { + "input": "Definition: something described as a NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.", + "output": "NOD SIGNALING ADAPTOR PROTEIN 02 (CARD Signaling Adaptor Proteins)" + }, + { + "input": "Definition: Unit of Magnetic Permeability described as a SI unit of magnetic permeability equal to one kilogram meter per second squared per ampere squared.", + "output": "Henry per Meter (Unit of Magnetic Permeability)" + }, + { + "input": "Definition: Data described as a representation of a clinical variable, fact, concept, or instruction in a manner suitable for communication, interpretation, or processing by humans or by automated means. NOTE: Items are collected together to form item groups. [CDISC] Compare to data item, item (PRO).", + "output": "Clinical Item (Intellectual Product)" + }, + { + "input": "Definition: Adverse Event Associated with the Gastrointestinal System described as a disorder characterized by difficulty in swallowing.", + "output": "Dysphagia (Gastrointestinal Disorders, CTCAE)" + }, + { + "input": "Definition: Finding described as having a characteristic appearance of a slate gray area of pigmentation within the disc margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas.", + "output": "Optic nerve grey crescent (Finding)" + }, + { + "input": "Definition: positive regulation of interleukin-1 production described as any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell.", + "output": "up-regulation of interleukin-1 secretion (Cell Function)" + }, + { + "input": "Definition: Leukemoid Reaction described as increased white blood cell count and increased neutrophil precursors resembling leukemia in a neonate or fetus. Often, this is a response to medications received, infection or Down syndrome.", + "output": "infantile pseudoleukemia (Disorder of cellular component of blood in newborn)" + }, + { + "input": "Definition: something described as cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA.", + "output": "chromatin silencing by small RNA, production of siRNA (Genetic Function)" + }, + { + "input": "Definition: something described as nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes.", + "output": "Nasopharyngeal Cancer pN1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the medical science and specialty practice concerned with all aspects of disease of the genital tract, endocrine system, and reproductive system of the female.", + "output": "Gynecologic pathology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cyclophosphamide, methotrexate, fluorouracil, and fluoxymesterone that may be used as maintenance therapy for breast cancer.", + "output": "Cyclophosphamide/Fluorouracil/Fluoxymesterone/Methotrexate Cyclophosphamide-Fluorouracil-Fluoxymesterone-Methotrexate (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Disorder of ocular adnexa described as a rare form of myositis that only affects the orbital muscles.", + "output": "Myositides, Orbital (Muscle infections and inflammations)" + }, + { + "input": "Definition: Urinary system subdivision described as the duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.", + "output": "genitourinary tracts (URINARY TRACT: GENERAL TERMS)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Toddler Parent Report - In the past one month, how much of a problem has this been for your child: I think our family has a lot of problems.", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent of Toddler - Family Has Lot of Problems (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)" + }, + { + "input": "Definition: something described as subphylum of chordates intermediate between the invertebrates and the true vertebrates; includes the Ascidians.", + "output": "tunicate (Chordata)" + }, + { + "input": "Definition: Clinical history and observation findings described as clinical, laboratory or molecular evidence, or absence of evidence of disease.", + "output": "Signs and Symptoms (Diagnosis Classification)" + }, + { + "input": "Definition: Vestibulocochlear Physiological Phenomena described as the process whereby auditory stimuli are selected, organized, and interpreted by the organism.", + "output": "auditory perception (Perception)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Child Report (PedsQL Neuromuscular Module Acute Version 3.0 Child Report) In the past 7 days, how much of a problem has this been for you: It is hard to swallow food.", + "output": "PQL14-Hard to Swallow Food (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)" + }, + { + "input": "Definition: Organism Function described as the transmission of information about sexual status from the initial, general, determination to signals specific to the soma.", + "output": "primary sex determination, soma (primary sex determination)" + }, + { + "input": "Definition: something described as a device designed to measure a time interval.", + "output": "timers (manufactured apparatus)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate.", + "output": "2-acetolactate methylmutase activity (Molecular Function)" + }, + { + "input": "Definition: RNA-Binding Proteins described as serine/arginine-rich splicing factor 2 (221 aa, ~25 kDa) is encoded by the human SRSF2 gene. This protein plays a role in the modulation of mRNA processing.", + "output": "SC-35 (RNA-Binding Proteins)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as an invasive therapeutic procedure to destroy tissue in the cardiac atria that is the source of an arrhythmia.", + "output": "ABLATION, ATRIAL (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Finding described as abnormal bone tissue formation (ossification) affecting the sacrum. []", + "output": "Abnormal ossification of the sacrum (Abnormal sacrum morphology)" + }, + { + "input": "Definition: Mammal described as an order of wholly aquatic MAMMALS occurring in all the OCEANS and adjoining seas of the world, as well as in certain river systems. They feed generally on FISHES, cephalopods, and crustaceans. Most are gregarious and most have a relatively long period of parental care and maturation. Included are DOLPHINS; PORPOISES; and WHALES.", + "output": "Cetacean (Eutheria)" + }, + { + "input": "Definition: Therapy-related acute myeloid leukemia and myelodysplastic syndrome described as a subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with cytotoxic agents, like etoposide, doxorubicin, daunorubicin and others. The neoplastic cells often show rearrangements involving the mixed lineage leukaemia gene at 11q23. This subgroup of t-MN is typically associated with overt leukaemia, without preceding myelodysplastic syndrome, developing 2-3 years after exposure, presenting with non-specific symptoms related to ineffective haematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement.", + "output": "acute therapy rel myeloid leuk & myelodys syn rel to topoisomerase type 2 inhib (Sequela of disorder)" + }, + { + "input": "Definition: wound care described as limitation of the blood loss from a wound that may be a result of trauma, incisions, or placement of a tube or catheter", + "output": "Bleeding Reduction: Wound (Control of hemorrhage)" + }, + { + "input": "Definition: Expanded DRS-PI Caregiver Version Questionnaire Question described as expanded Disability Rating Scale - Postacute Interview Caregiver Version - Can [name] function with complete independence in work or social situations?", + "output": "Expanded DRS-PI Caregiver Version - Function With Independent Work or Social Situations (Intellectual Product)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, located at chromosome 7q31.2, which encodes the protein cystic fibrosis transmembrane conductance regulator. This protein functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. Transport of chloride ions helps control the movement of water in tissues and maintains the fluidity of mucus and other secretions. Genetic variants at this locus have been associated with hereditary pancreatitis, congenital bilateral absence of the vas deferens, cystic fibrosis, and bronchiectasis. Additionally, specific genetic variants have been associated with response to the drugs ivacaftor and lumacaftor in patients in whom cystic fibrosis has been diagnosed.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CFTR (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as new onset nephrotic syndrome.", + "output": "Incident Nephrotic Syndrome (Nephrotic Syndrome)" + }, + { + "input": "Definition: protein serine/threonine kinase activity described as catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.", + "output": "ribosomal protein S6 kinase activity (Molecular Function)" + }, + { + "input": "Definition: Active complement enzyme of alternative pathway described as the larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.", + "output": "C3b, Complement (Immunologic Factor)" + }, + { + "input": "Definition: something described as a person trained to for provide personal patient care and related services for ill or disabled patients, and elderly in home or home-like settings to get patients needs met. The tasks performed by home health aide include personal care, homemaking, communications, working with the patient occupational therapist, physical therapist and other caregivers to assure that the patients are reaching their best physical, mental and social well-being.", + "output": "Home Health Aid (Unlicensed Assistive Personnel)" + }, + { + "input": "Definition: Photoreceptors described as a photoreceptor cell located in the retina of the eye that allows low light vision.", + "output": "Rod Cell (Cell)" + }, + { + "input": "Definition: Temperature described as having less heat energy than the object against which it is compared; the absence of heat.", + "output": "Cold, NOS (Physical force)" + }, + { + "input": "Definition: Urine xenobiotic described as detection of opioids or opioid metabolites in urine. []", + "output": "Positive urine opioid test (Finding)" + }, + { + "input": "Definition: Amino Acid Sequence described as a family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS.", + "output": "Domain Superfamily, Death (Amino Acid Sequence)" + }, + { + "input": "Definition: Manufactured Object described as carts designed for safe storage, transportation, and easy access of facsimile (fax) equipment and/or computer printers. These carts usually consist of a metal, wooden, and/or plastic open or semi-enclosed structure with a frame that includes several shelves and a top with a non-slip surface for the fax machine and/or printers. Most carts include a set of large (e.g., 10 or 15 cm/4 or 6 inch) casters that may include brakes, drawers, electric power connectors, and attachments for cable management; some carts are height adjustable.", + "output": "Printer Storage/Transport Carts (Manufactured Object)" + }, + { + "input": "Definition: Finding described as community actions to eliminate or reduce the incidence of chronic diseases and related complications", + "output": "Community Risk Control: Chronic Disease (Finding)" + }, + { + "input": "Definition: ECZEMETOUS ABNORMALITIES described as common polygenetically determined, chronic, squamous dermatosis characterized by rounded erythematous, dry, scaling patches.", + "output": "Psoriasis (Hypertrophic disorder of skin, unspecified)" + }, + { + "input": "Definition: Lower bowel endoscopy - removal of object described as an endoscopic procedure that visualizes the upper part of the gastrointestinal tract up to the duodenum.", + "output": "Oesophagogastroduodenoscopy (Gastrointestinal and abdominal imaging procedures)" + }, + { + "input": "Definition: Biologically Active Substance described as g1/S-specific cyclin-D1b is encoded by the human CCND1 gene. This protein may play a role in the promotion of tumor cell invasiveness and anchorage-independent growth.", + "output": "Cyclin D1b (Biologically Active Substance)" + }, + { + "input": "Definition: something described as diabetes Distress Scale for Adults with Type 1 Diabetes - Subscale 7 - Friend/family distress.", + "output": "T1-DDS - Subscale 7: Friend/Family Distress (Intellectual Product)" + }, + { + "input": "Definition: Tissue membrane described as the inner aspect of the sclera, located adjacent to the choroid. It contains thin collagen fibers and elastic fibers, fibroblasts, melanocytes, macrophages, and other connective tissue cells.", + "output": "Lamina Fusca (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol.", + "output": "xylene monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Progestins described as a pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.", + "output": "3 alpha Hydroxy 5 beta pregnan 20 one (Anesthetics)" + }, + { + "input": "Definition: Specific antigen described as cathepsin D (412 aa, ~45 kDa) is encoded by the human CTSD gene. This protein is involved in proteolysis.", + "output": "cathepsin D (Cathepsins)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "output": "regulation of extracellular matrix breakdown (regulation of extracellular matrix organization)" + }, + { + "input": "Definition: Unit of Electricity and Magnetism described as a unit for measurement of magnitude of the electrical current per cross-sectional area.", + "output": "Unit of Electric Current Density (Quantitative Concept)" + }, + { + "input": "Definition: Findings-Based Question described as a question about how an individual would describe the usual quality of their erections without the assistance of medications or devices during the last four weeks.", + "output": "How would you describe the usual quality of your erections WITHOUT THE ASSISTANCE of medicines or devices DURING THE LAST 4 WEEKS (Findings-Based Question)" + }, + { + "input": "Definition: Organ Preservation Solutions described as solutions designed to maintain temporary viability (usually from 7 to 14 days) of donated corneas outside the human body until implant. Corneal preservation solutions usually contain sterilized water and other substances (e.g., polyoxyethylene/polyoxypropylene copolymers, chondroitin sulfate, insulin, cell nutrients, antibiotics, buffers and other preservatives) to maintain the life of the keratocytes in the cornea until it is needed for implant. They are used by eye tissue banks.", + "output": "Organ Preservation Solutions, Corneal Storage (Biomedical or Dental Material)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as an area of the cerebral cortex originally defined on the basis of myeloarchitecture and cytoarchitecture in the guenon. It represented the portion of area 3 of Brodmann (guenon) that Brodmann regarded as transitional to area 4 of Brodmann (guenon). The Vogts distinguished it as one of two subdivisions of area 3. The other was area 3a of Vogts ( Vogts-1919 ). 'Area 3b' continues to be the most common name for the structure. It is now recognized as differing from 3a not only in architecture but by its input, which comes primarily from skin receptors, its output caudally and reciprocally to area 1 of Brodmann ( guenon ), area 2 of Brodmann (guenon) and the second somatosensory area and its more direct involvement in sensory functions than 3a. Functionally it is a subdivision of the somatosensory cortex. It is considered equivalent to area 3b in the human and the macaque ( Kaas-2004 ).", + "output": "area 3b of Vogts (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Quantitative Concept described as the percentage of the administered dose that is recovered from the specimen type specified in PPSPEC extrapolated to infinity, calculated using the predicted value of the last non-zero concentration.", + "output": "Pct Rec Infinity Pred (Percent Recovered)" + }, + { + "input": "Definition: Centrifuges, Tabletop described as tabletop centrifuges which usually operate at speeds of 30,000 to 120,000 rpm and relative centrifugal forces of 50,000 to over 800,000 gravities. Ultracentrifuges must be refrigerated because air friction created at ultrahigh-speed generates heat that could decompose the components being centrifuged. These devices are used for lipoprotein separation, isolation of viruses, enzymes, and blood fractions for analysis and make possible the fractionation of DNA and RNA and other studies of structures and functions within the cell.", + "output": "Centrifuges, Tabletop, Ultrahigh-Speed (Medical Device)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of androstenedione secretion.", + "output": "regulation of androstenedione secretion (Organ or Tissue Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective answer of very mild agreement regarding the importance of something.", + "output": "A little important (Intellectual Product)" + }, + { + "input": "Definition: Surgical Scissors described as surgical scissors designed to cut small-caliber suturing wires. These scissors are typically sturdy handheld, manual instruments with two metallic (e.g., stainless steel) and frequently serrated blades with straight, angled, or curved sharp tips that slide past each other (i.e., shearing action); a blade may include a notch to facilitate rapid pickup and cutting. The blades are attached to handles, with the proximal end conformed as a ring to facilitate holding and operating with the fingers; both parts are joined by a swivel pin in the center. Wire-cutting scissors are used to cut wire sutures in plastic and/or orthopedic surgery; many wire cutting scissors are also used to cut metallic mesh used in surgical procedures (e.g., hernia). Smaller dedicated wire cutting scissors are available to cut wire ossicle prosthesis.", + "output": "Wire Cutting Surgical Scissors (Medical Device)" + }, + { + "input": "Definition: something described as a caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.", + "output": "Inflammatory Apoptosis (Cell Death)" + }, + { + "input": "Definition: Structural modification described as exteriorisation of an enclosed cavity by incision and suturing of edges to adjacent tissue.", + "output": "Construction of pouch (Exteriorization - action)" + }, + { + "input": "Definition: Fishes described as common name for a family of eel-shaped jawless fishes (Myxinidae), the only family in the order MYXINIFORMES. They are not true vertebrates.", + "output": "Family Myxinidae - hagfish (Myxiniformes)" + }, + { + "input": "Definition: something described as catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8.", + "output": "sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a drug therapy that is used to destroy cancer cells.", + "output": "Cytotoxic Therapy (Pharmacotherapy)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of osmosensory signaling pathway.", + "output": "regulation of osmosensory signaling pathway (Cell Function)" + }, + { + "input": "Definition: Analyzers, Physiologic described as physiologic analyzers that measure, record, and process the basal body temperature of women to determine the fertile and infertile phases of the menstrual cycle. These analyzers are automatic, electronic, portable handheld instruments; they typically include a thermometer and a microprocessor programmed with a mathematical algorithm to calculate and identify temperature shifts and their relation to fertility phases.", + "output": "Analyzers, Physiologic, Thermometric Fertility Cycle (Device associated with batteries)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a subtest of the Wechsler Memory Scale, 4th Edition that evaluates immediate recall. The subject is shown a grid with 4-8 designs on a page for 10 seconds, which is then removed from view. The subject then selects the designs from a set of cards and places the cards in a grid in the same place as previously shown.", + "output": "wms-iv subtests designs i (Intellectual Product)" + }, + { + "input": "Definition: amino acid import across plasma membrane described as the directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol.", + "output": "L-alanine import across plasma membrane (Cell Function)" + }, + { + "input": "Definition: norepinephrine transport described as the regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.", + "output": "norepinephrine secretion (Cell Function)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify species of Chlamydia, a genus of intracellular bacteria of the family Chlamydiaceae, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target bacteria. These bacteria species may cause a variety of diseases in humans, including trachoma, conjunctivitis, atypical pneumonia, encephalomyelitis, and a variety of urogenital infections.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydia Species, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydia Species)" + }, + { + "input": "Definition: Cervical Cancer pT2a TNM Finding v8 described as cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension.", + "output": "Cervical Carcinoma FIGO Stage IIA2 (Cervical Cancer pT2a TNM Finding v8)" + }, + { + "input": "Definition: Deposition described as a structure found in some benign (not cancer) or malignant (cancer) tumor cells. Psammoma bodies look like hardened concentric rings when viewed under a microscope. They can be a sign of chronic inflammation.", + "output": "body psammoma (Pathologic mineralization)" + }, + { + "input": "Definition: Antifungal Agents described as a substituted salicylamide with antimycotic activity, particularly against dermatophytes.", + "output": "BUTYLPHENAMIDE (Pharmacologic Substance)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the tubular tract in female animals through which eggs are discharged either to the exterior or, in mammals, to the uterus.", + "output": "Oviducts (Experimental Organism Anatomical Concept)" + }, + { + "input": "Definition: Globulin measurement described as the determination of the amount of alpha-1 globulin present in a sample.", + "output": "A1-Globulin (Globulin measurement)" + }, + { + "input": "Definition: Organic Chemical described as a steroid derivative characterized by the hydroxyl group in position C-3 of the steroid skeleton, elimination of carbon 24.2 of the alkyl substituent, and unsaturated bonds in position 5-6 of the B ring, and position 22-23 in the alkyl substituent. It is synthesized by several unicellular algae and some terrestrial plants.", + "output": "brassicasterol (phytosterols)" + }, + { + "input": "Definition: something described as a docosanoid and a structural analogue of an inactive biosynthetic cyclic derivative of arachidonic acid, 13,14-dihydro-15-keto-prostaglandin F 2a. Although the mechanism of action is unknown, unoprostone isopropyl may reduce elevated intraocular pressure by increasing the outflow of aqueous humor upon ocular administration.", + "output": "Product containing unoprostone isopropyl (I [Preparations])" + }, + { + "input": "Definition: Immunologic Factor described as a peptide derived from the oncogenic human papillomavirus (HPV) early gene product E6. The HPV 16 transforming protein E6 is expressed in precancerous and malignant cervical lesions and has a high affinity for the most common human lymphocyte antigen (HLA), HLA-A2. Immunogenic peptides from the HPV 16 E6 may be used to trigger a T-cell-mediated immune response to HPV.", + "output": "HPV 16 E6:18-26 (Immunologic Factor)" + }, + { + "input": "Definition: something described as exhibiting or pertaining to microinvasion, the microscopic extension of malignant cells into adjacent tissue in carcinoma in situ.", + "output": "microinvasive (Qualitative Concept)" + }, + { + "input": "Definition: something described as a class which hold the roles which are assumed by a particular group in the context of a protection group.", + "output": "User Role Context (Conceptual Entity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type.", + "output": "CPK-MB, Isoenzyme (Enzymes)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as molecular assay reagents intended to identify deletions in the dystrophin muscular dystrophy (DMD) gene, located in Xp21.2, which encodes for the protein dystrophin that may anchor the cytoskeleton to the plasma membrane and stabilize the muscle during contractions. X-linked recessive inherited deletions are present in Duchenne muscular dystrophy (DMD) and also in a somewhat milder disease known as Becker muscular dystrophy (BMD).", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DMD (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Psychotherapy described as a form of supportive psychotherapy in which the patient is given carefully selected material to read.", + "output": "Bibliotherapies (Psychotherapy)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the BRAF gene that inhibits expression or results in the translation of either low-activity or inactive forms of the serine/threonine-protein kinase B-raf protein.", + "output": "Inactivating B-RAF Gene Mutation (BRAF gene mutation)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 22q", + "output": "22q11.22 (Chromosome band)" + }, + { + "input": "Definition: Oral infection described as mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry.", + "output": "mulberry molar (Disturbances in tooth formation)" + }, + { + "input": "Definition: Professional or Occupational Group described as dentists with special training in prosthetic dentistry.", + "output": "Prosthodontics (Dentist)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as REST-003 ncRNA (~460 base pairs) is encoded by the human REST gene. This transcript includes all of exon 1 and a portion of exon 2 of the gene and may play a role in the negative regulation of cellular invasiveness.", + "output": "REST-003 ncRNA (Long Intergenic Non-Protein Coding RNA)" + }, + { + "input": "Definition: Mammal described as a small, smart, inquisitive, and playful dog with a broad, wedge-shaped head, and erect V-shaped ears. The skin is smooth and warm to the touch, and eyebrows and whiskers are sometimes present. The average height range is 12-16 inches and the average weight range is 12-16 pounds.", + "output": "American Hairless Terrier (Mammal)" + }, + { + "input": "Definition: something described as bing lang, da fu pi", + "output": "areca/bing lang/da fu pi (Plant)" + }, + { + "input": "Definition: negative regulation of nuclear cell cycle DNA replication described as any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication.", + "output": "down regulation of DNA replication during S phase involved in mitotic cell cycle (Cell Function)" + }, + { + "input": "Definition: Food described as symbiotic associations of different, predominantly LACTIC ACID-producing bacteria and yeast that exist in a polysaccharide and protein matrix, forming small grain-like aggregates in KEFIR.", + "output": "Kefir Grains (Food)" + }, + { + "input": "Definition: Statistical Measurement described as statistical procedures used to forecast the value of the criterion variables (such as behavior, performance, or outcomes) on the basis of selected predictor variables.", + "output": "Predictability (Quantitative Concept)" + }, + { + "input": "Definition: Nitrogen and nitrogen compound described as sometimes used interchangeably with pyrrole; sometimes used to mean a pyrrole with at least one more hetero atom (N,O,S, etc.) in the ring.", + "output": "azole (Heterocyclic Compounds, 1-Ring)" + }, + { + "input": "Definition: something described as computer-processable annotations within a multimedia document. NOTE: in the context of the HL7 specification, markup syntax is according to the XML specification.", + "output": "Markup (Machine Activity)" + }, + { + "input": "Definition: DRRI-2 Questionnaire Question described as deployment Risk and Resilience Inventory-2 (DRRI-2) Either in preparation for or during my deployment: I received preventative vaccinations by injection (for example, to prevent anthrax or botulism).", + "output": "DRRI1-F: Received Vaccinations (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Skin neoplasms malignant and unspecified described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis.", + "output": "Stage 0 Skin Cancer (Epithelial neoplasm of skin)" + }, + { + "input": "Definition: Pharyngeal pouch described as a paired evagination of embryonic pharyngeal endoderm located between pharyngeal arches three and four, which contributes to the formation of both the inferior parathyroid gland and the thymus gland.", + "output": "Third Pharyngeal Pouch (Embryonic pharyngeal pouch structure)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide.", + "output": "lachrymatory factor synthase activity (intramolecular oxidoreductase activity)" + }, + { + "input": "Definition: Organ component cluster described as orbital structure; a fibrous ring that is the origin of the rectus muscles", + "output": "Anulus of Zinn (Ocular adnexal part)" + }, + { + "input": "Definition: something described as an abnormality of the columella.", + "output": "Deformity of the columella (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as casework designed for use in examination rooms. This furniture usually includes sturdy wall cabinets; examination room furniture may also include other stand-alone cabinets with dedicated sinks and faucets. Examination room casework is made of hard plastic and/or metallic materials with an appropriate finish for ease of cleaning and sanitation.", + "output": "Examination Room Casework (Casework)" + }, + { + "input": "Definition: Bacterium described as a species of facultatively anaerobic, Gram negative, rod shaped bacteria in the phylum Proteobacteria. This species is motile, peritrichous, citrase and esterase positive, decarboxylase negative and can support growth on and produce acid from arabinose, melibiose, rhamnose, sorbitol, and xylose. S. rubidaea is found naturally in plants and pathogenesis is associated with the ingestion of contaminated coconuts or vegetables.", + "output": "Serratia rubidaea (Stapp 1940) Ewing et al. 1973 (Bacterium)" + }, + { + "input": "Definition: Qualitative Concept described as a category specifying that a product is marketed as unapproved homeopathic product.", + "output": "UNAPPROVED HOMEOPATHIC (Structured Product Labeling Marketing Category)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with brain malformations, a collection of conditions in which the brain develops abnormally, resulting in absence of brain structures, aberrant growth of brain structures, or incomplete division of the brain. Genetic variants at multiple loci have been associated with brain malformations. These reagents are intended to detect mutations in the majority of brain malformation-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Comprehensive, Mutation (IVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Comprehensive)" + }, + { + "input": "Definition: Laboratory or Test Result described as indicates that expression of the EML4/ALK fusion has not been detected in a sample.", + "output": "EML4/ALK Negative (Rearrangement Negative)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the 10 Meter Walk/Run functional test.", + "output": "10 Meter Walk/Run Functional Test Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Health Care Related Organization described as an institute within the National Institutes of Health with the mission to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.", + "output": "National Institute of Environmental Health Sciences (Health Care Related Organization)" + }, + { + "input": "Definition: negative regulation of multicellular organismal process described as any process that stops, prevents or reduces the frequency, rate or extent of lactation.", + "output": "down-regulation of lactation (Physiologic Function)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a hereditary neurological disorder with early and severe involvement of both the peripheral and central nervous systems. It has only been described in Finnish families. Some patients show intellectual deficit. Epilepsy is a late manifestation and seizures may be life threatening. Caused by mutations in the C10orf2 gene (10q24) encoding the mitochondrial helicase Twinkle. The c.1523A>G (p.Y508C) causative mutation has been postulated to be a founder mutation. The mutations lead to mtDNA depletion in the brain and the liver but not in the muscle. Inherited in an autosomal recessive manner.", + "output": "Ophthalmoplegia, hypotonia, ataxia, hypacusis, and athetosis (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: something described as a very rare syndrome of congenital hypothyroidism with characteristics of thyroid dysgenesis, cleft palate and spiky hair, with or without choanal atresia, and bifid epiglottis. Facial dysmorphism and porencephaly have been reported in isolated cases. Only 8 patients from 6 families have been reported to date. Newborns present at birth with thyroid dysgenesis (in most cases athyreosis) leading to congenital hypothyroidism that manifests with lethargy, poor feeding, macroglossia, cold or mottled skin, persistent jaundice and umbilical hernia. All newborns have a cleft palate and spiky hair. The syndrome is due to homozygous loss-of-function missense mutations located within the forkhead domain of the FOXE1 gene (9q22), encoding thyroid transcription factor 2 (TTF-2). TTF-2 is expressed in the thyroid gland (as well as elsewhere like the tongue, epiglottis and palate) and is thought to play a crucial role in thyroid morphogenesis. The disease is inherited autosomal recessively.", + "output": "Hypothyroidism and cleft palate syndrome (Congenital Hypothyroidism)" + }, + { + "input": "Definition: Organism Function described as any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.", + "output": "Inhibition of host STAT2 by virus (suppression by virus of host STAT activity)" + }, + { + "input": "Definition: something described as penile cancer in which the primary tumor cannot be assessed.", + "output": "Penile Cancer pTX TNM Finding v7 (Penile Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Kind of quantity described as a constant number that serves as a measure of some property or characteristic.", + "output": "*Coefficient (Multiplier - number)" + }, + { + "input": "Definition: Finding described as body Mass Index (kg/m\u00b2) from 35.00 to 39.99 (WHO. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization, 1995).", + "output": "Obese class II (Obesity)" + }, + { + "input": "Definition: something described as a rare flea-borne Rickettsial disease caused by a Rickettsia felis infection. Patients can be asymptomatic or can present with unspecific symptoms such as fever, headache, generalized maculopapular rash, myalgia, arthralgia and, occasionally eschar, lymphadenopathy, nausea, vomiting, loss of appetite and abdominal pain. Rarely, serious manifestations may occur and include neurological dysfunction (photophobia, hearing loss and signs of meningitis) and pulmonary compromise.", + "output": "Pseudotyphus of California (Disease or Syndrome)" + }, + { + "input": "Definition: Fluid consistency type described as nectar consistency. Steady, fast flow. Pours quickly from a cup, but slower than regular, unmodified fluids. May leave a coating film of residue in the cup after being poured (Source: Academy of Nutrition and Dietetics Nutrition Informatics Committee 2013).", + "output": "Nectar-thick fluid (Fluid consistency type)" + }, + { + "input": "Definition: something described as the directed movement of lipopolysaccharides out of a cell or organelle.", + "output": "LPS export (Cell Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as teaching a patient and/or caregiver the proper techniques to manage and/or control his or her communicable infection(s).", + "output": "teaching of infection control (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+).", + "output": "2,6-dihydroxypyridine 3-monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Tethered Cord Syndrome described as a genetic non-syndromic congenital malformation of the neurenteric canal, spinal cord and column characterized by progressive neurologic deterioration (pain, sensorimotor deficits, abnormal gait, decreased tone or abnormal reflexes), musculoskeletal changes (foot deformities and asymmetry, muscle atrophy, limb weakness and numbness, gait disturbances, scoliosis) and/or genitourinary manifestations (bladder and bowel dysfunction). Midline cutaneous stigmata in the lumbosacral region, such as turfs of hair, skin appendages, dimples, subcutaneous lipomas, skin discoloration or hemangiomas, are frequently associated.", + "output": "primary tethered cord syndrome (Congenital Abnormality)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Description of active suicidal ideation with any methods (not plan) without intent to act.", + "output": "C-SSRS Lifetime/Recent Version - Description of Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: Nucleus of tectum described as used by some authors as a composite term to refer to the cell groups of the inferior colliculus, namely the central nucleus of the inferior colliculus, the pericentral nucleus of the inferior colliculus and the external nucleus of the inferior colliculus ( Riley-1943 ).", + "output": "Set of nuclei of inferior colliculus (Set of neuraxis structures)" + }, + { + "input": "Definition: Korean Standard Classification of Disease Version 5 described as a contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.", + "output": "Scabies (Mite Infestations)" + }, + { + "input": "Definition: something described as absence of a lobe of the thyroid gland related to a failure of its embryologic development.", + "output": "Congenital hemiagenesis of thyroid (Disease or Syndrome)" + }, + { + "input": "Definition: Physiologic Function described as any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.", + "output": "positive regulation of timing of anagen (regulation of timing of anagen)" + }, + { + "input": "Definition: Retinal structural change, deposit and degeneration described as deterioration of the macula lutea in the retina; may be inherited, drug induced, or due to aging; leads to a severe loss of central vision while peripheral vision is retained.", + "output": "Macular Degenerations (Abnormal macular morphology)" + }, + { + "input": "Definition: Organic Chemical described as an inhibitor of the Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that bind to acetylated lysines on the tails of histones H3 and H4, and regulate chromatin structure and function; they play an important role in the modulation of gene expression during development and cellular growth.", + "output": "BET inhibitor BMS-986158 (Pharmacologic Substance)" + }, + { + "input": "Definition: Endocarditis described as prosthetic valve endocarditis that occurs several months to years following valve replacement.", + "output": "Late Prosthetic Valve Endocarditis (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide.", + "output": "purine deoxyribonucleotide interconversion (purine nucleotide interconversion)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.", + "output": "Betaine-Homocysteine S-Methyltransferase (Transferase)" + }, + { + "input": "Definition: G-Protein-Coupled Receptors described as melanocyte-stimulating hormone receptor (317 aa, ~35 kDa) is encoded by the human MC1R gene. This protein plays a role in both hormone binding and melanogenesis.", + "output": "melanotropin receptor (Receptor)" + }, + { + "input": "Definition: Device Approval described as the process of gaining approval by a government regulatory agency for DIAGNOSTIC REAGENTS AND TEST KITS. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance.", + "output": "Approvals, Diagnostic Test (Device Approval)" + }, + { + "input": "Definition: Finding described as an adverse event in a newborn characterized by moderate clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event; meeting criteria for therapeutic hypothermia.", + "output": "Grade 3 Hypoxic Ischemic Encephalopathy (Finding)" + }, + { + "input": "Definition: Immunodeficiency associated with other major defects described as primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.", + "output": "Job Syndrome (Congenital hypergammaglobulinemia)" + }, + { + "input": "Definition: Photic Stimulation described as visual stimulation technique in which special lenses are used to spatially distort or invert visual images or the visual field. Also includes prisms that differentially refract light of different wavelengths to produce an array or spectrum of colors.", + "output": "Prismatic Stimulation (Human-caused Phenomenon or Process)" + }, + { + "input": "Definition: peptide hormone described as a protein encoded by the human INS gene.", + "output": "INS Gene Product (peptide hormone)" + }, + { + "input": "Definition: something described as difficulty reaching to visually guided goals in peripheral vision, with the deficit leaves voluntary eye movements largely unaffected.", + "output": "Optic ataxia (Central Nervous System)" + }, + { + "input": "Definition: Sign or Symptom described as birth weight less than 1500 grams.", + "output": "birth low very weight (Sign or Symptom)" + }, + { + "input": "Definition: Abnormality of the curvature of the vertebral column described as abnormal lateral curvature of spine", + "output": "Scoliosis deformity of spine (Spinal Diseases)" + }, + { + "input": "Definition: Medicinal product categorized by therapeutic role described as substances used to allow enhanced visualization of tissues.", + "output": "Contrast Agents (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Body Location or Region described as a cortical structure located in the anterior half of inferior parietal cortex, a region much expanded in humans relative to macaques and chimpanzees. It is bounded dorsally by area 2, caudally by area AIP, rostrally by area 1, and ventrally by area PF and area PFop. Defined by multiple criteria, it is fMRI-activated in EMOTION and SOCIAL tasks. It is deactivated in a LANGUAGE task and more deactivated in a FACES task. Other authors have referred to the same topological area as 72 and 88 of the Vogts ( Glasser-2016 ).", + "output": "PFt (Body Location or Region)" + }, + { + "input": "Definition: something described as in evolutionary theory, overlapping geographic distribution of diverging species. In sympatric GENETIC SPECIATION, genetic diversion occurs without geographic separation.", + "output": "Sympatry (Genetic Phenomena)" + }, + { + "input": "Definition: Organic Chemical described as an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.", + "output": "Product containing sufentanil (thiophene)" + }, + { + "input": "Definition: something described as a dose calculation unit expressed in hours times picograms per milliliter, divided by milligram per kilogram per day.", + "output": "h*pg/mL/(mg/kg/day) (Measurement Unit Description)" + }, + { + "input": "Definition: something described as a rule which guides how an activity should be performed.", + "output": "Protocol (Reference documentation)" + }, + { + "input": "Definition: something described as homeobox protein Nkx-3.1 (234 aa, ~26 kDa) is encoded by the human NKX3-1 gene. This protein plays a role in the modulation of transcription.", + "output": "NKX3A (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as care that supports effective use of the health care delivery system", + "output": "Health System (Nursing Interventions Classification)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a solid growth medium that is modified based on the Middlebrook 7H10 agar by the addition of pancreatic digest of casein.", + "output": "Middlebrook 7H11 agar (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as an orally bioavailable capsule formulation of the inorganic toxic compound arsenic trioxide (As2O3), with potential antineoplastic activity. Although the mechanism of action (MoA) of As2O3 is not well understood, upon oral administration of ORH 2014, As2O3 appears to bind to DNA, prevent DNA synthesis, and cause DNA fragmentation, which leads to an induction of apoptosis in proliferating cells, including tumor cells. In addition, As2O3 causes damage to and induces degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein, and inhibits the activity of the enzyme thioredoxin reductase.", + "output": "As2O3 Formulation ORH 2014 (Differentiation Inducer)" + }, + { + "input": "Definition: something described as an automated slide stainer is a device used to stain histology, cytology, and hematology slides for diagnosis.", + "output": "SLIDE STAINER, AUTOMATED (Medical Device)" + }, + { + "input": "Definition: something described as the dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.", + "output": "efatutazone dihydrochloride (Pharmacologic Substance)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase (AMPK) and reduces mammalian target of rapamycin (mTOR) signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.", + "output": "COR (Pharmacologic Substance)" + }, + { + "input": "Definition: Reproductive System Finding described as bleeding originating in the organs and tissue that aid in reproduction.", + "output": "Reproductive system haemorrhages (Reproductive System Finding)" + }, + { + "input": "Definition: Excessive mineral intake described as higher intake of chromium compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)", + "output": "Excessive chromium intake (Excessive mineral intake)" + }, + { + "input": "Definition: something described as any process involved in forming the mature 3' end of a non-coding RNA molecule.", + "output": "ncRNA 3'-end processing (RNA 3' End Processing)" + }, + { + "input": "Definition: Operating microscope described as operating microscopes with slim bodies designed using combinations of couplers, objectives, lenses, and body tubes for specific use in gynecologic (e.g., fallopian tubes) surgery. Gynecologic microscopes may have an independent mount or may be attached to a gynecologic/obstetric table or chair.", + "output": "Microscopes, Gynecologic (Operating microscope)" + }, + { + "input": "Definition: something described as penile cancer with no evidence of primary tumor.", + "output": "Penile Cancer pT0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Organic Chemical described as an orally available, small molecule inhibitor of the human homolog of murine double minute 2 (MDM2; HDM2), with potential antineoplastic activity. Upon oral administration, MDM2 antagonist ASTX295 targets and binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. This prevents p53 proteasomal degradation and restores the transcriptional activity of p53. This leads to p53-mediated induction of apoptosis in cancers with a wild-type p53 gene. MDM2, an E3 ubiquitin ligase, regulates the level and activity of p53.", + "output": "ASTX 295 (Pharmacologic Substance)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as MIR206 is an oligoribonucleotide that is encoded by the human MIR206 gene and has a role in the regulation of gene expression.", + "output": "MIR206 Pre-miRNA (pre-miRNA)" + }, + { + "input": "Definition: Medical Devices described as a tool consisting of a pair of handled jaws designed for holding and pulling.", + "output": "Pincers (Medical Devices)" + }, + { + "input": "Definition: Laboratory or Test Result described as a genetic finding indicating that the sonic hedgehog/patch pathway is inactivated.", + "output": "Sonic Hedgehog/Patch Pathway Inactivated (Signaling Pathway Status)" + }, + { + "input": "Definition: Cell Component described as a protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.", + "output": "G-protein coupled receptor homodimeric complex location (G protein-coupled receptor dimeric complex)" + }, + { + "input": "Definition: intramolecular lyase activity described as catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate.", + "output": "(+)-copalyl-diphosphate lyase (Molecular Function)" + }, + { + "input": "Definition: cellular diagnosis, breast cancer described as a benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2977\" active clinical trials using this agent.", + "output": "cystosarcoma phylloides (Borderline phyllodes tumor)" + }, + { + "input": "Definition: In Vitro Diagnostics and Laboratory Equipment described as devices used to determine the number of bacterial colonies present on a bacteriological culture medium.", + "output": "Counters, Colony (Medical Device)" + }, + { + "input": "Definition: Pharmacologic Substance described as a water-soluble, nano-sized formulation composed of nanoparticles encapsulating the poorly water-soluble curcumin, a signal transducer and activator of transcription 3 (Stat3), nuclear factor Kappa B (NF-kB) and poly-tyrosine kinase inhibitor (TKI), and the antineoplastic anthracycline antibiotic doxorubicin, with potential antineoplastic activity. Upon administration of the curcumin/doxorubicin-encapsulating nanoparticle IMX-110, the curcumin moiety targets and inhibits the activation of STAT3 and NF-kB and prevents STAT3- and NF-kB-mediated signaling pathways, both of which are activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, tumor resistance to apoptosis, metastasis and immune evasion. The doxorubicin moiety intercalates into DNA and interferes with topoisomerase II activity. This inhibits DNA replication and RNA synthesis, leading to tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and curcumin, by inhibiting NFkB and STAT3 activity, may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells. Chemotherapeutic agents, such as doxorubicin, upregulate the expression of NF-kB in tumor cells which generates chemotherapy-resistant tumor cells.", + "output": "Stat3/NF-kB/poly-tyrosine kinase inhibitor/doxorubicin-encapsulating nanoparticle IMX-110 (Doxorubicin Preparation)" + }, + { + "input": "Definition: Flower Essences described as pacific dogwood.", + "output": "cornus nuttallii/pacific dog (Flower Essences)" + }, + { + "input": "Definition: something described as a collection of identifiers from an external system that contains distinct and discrete values in no particular order.", + "output": "Discrete Set Data Type IV (Qualitative Concept)" + }, + { + "input": "Definition: MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a potential tumor suppressor role in hepatocellular and prostate carcinomas, pituitary adenoma, as well as various leukemias and lymphomas.", + "output": "MIRN16-1 (Gene or Genome)" + }, + { + "input": "Definition: Hypertensive disease described as severe hypertension that is characterized by rapid onset of extremely high blood pressure.", + "output": "HYPERTENSION MALIGNANT (Disease or Syndrome)" + }, + { + "input": "Definition: Cell Aggregation described as the condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.", + "output": "cartilage condensation (Cell Aggregation)" + }, + { + "input": "Definition: something described as the evagination of a membrane, resulting in formation of a vesicle.", + "output": "vesicle biosynthesis (vesicle organization)" + }, + { + "input": "Definition: Laboratory or Test Result described as indicates that CD5 expression has been detected in a sample.", + "output": "CD5 Positive (Positive Laboratory Test Result)" + }, + { + "input": "Definition: Bacterium described as any bacterial species identified as Morganella morganii that is unable to metabolize ornithine.", + "output": "Morganella morganii, Ornithine-Negative (Morganella morganii)" + }, + { + "input": "Definition: Neoplastic Process described as a Malignant mesothelioma of the testis.", + "output": "Testicular mesothelioma (Neoplastic Process)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O.", + "output": "2,4-dichlorophenol monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: something described as dickkopf-related protein 4 (224 aa, ~25 kDa) is encoded by the human DKK4 gene. This protein is involved in the negative regulation of Wnt signaling.", + "output": "Dickkopf 4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child) In the past one month, how much of a problem has this been for your child: It is hard for our family to plan activities like vacations.", + "output": "PQL0621 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)" + }, + { + "input": "Definition: Finding described as unknown primary tumor with metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node.", + "output": "Unknown Primary Tumor pN3b TNM Finding v8 (Unknown Primary Tumor pN3 TNM Finding v8)" + }, + { + "input": "Definition: something described as a computer algorithm that provides a general method for partitioning the globular and non-globular regions of a protein sequence.", + "output": "SEG (Computer software)" + }, + { + "input": "Definition: Type of drug preparation described as a drug delivery system that often contains an adhesive backing that is usually applied to an external site on the body. Its ingredients either passively diffuse from, or are actively transported from, some portion of the patch. Depending upon the patch, the ingredients are either delivered to the outer surface of the body or into the body. A patch is sometimes synonymous with the terms Extended Release Film and System.", + "output": "PATCH (Unit dose)" + }, + { + "input": "Definition: Education, Nursing described as investigations into the problems of integrating research findings into nursing curricula, developing problem solving skills, finding approaches to clinical teaching, determining the level of practice by graduates from different basic preparations, etc.", + "output": "RESEARCH NURS EDUC (Nursing Research)" + }, + { + "input": "Definition: Ribosomal Interaction described as ribosome Assembly Interference involves inhibition or restraint of the formation of ribosomes.", + "output": "Ribosome Assembly Interference (Ribosomal Interaction)" + }, + { + "input": "Definition: something described as mesodermal tissue or tissue with mesodermal origin.", + "output": "mesenchyme (Embryonic Structure)" + }, + { + "input": "Definition: disorders of peripheral nerve, neuromuscular junction and muscle described as an autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.", + "output": "Polyneuritiformis, Hemeralopia Heredoataxia (Hereditary degenerative disease of central nervous system)" + }, + { + "input": "Definition: Pharmacologic Substance described as a long-acting aqueous gel preparation of lanreotide, a synthetic cyclic octapeptide analogue of somatostatin. Lanreotide inhibits the secretion of growth hormone (GH) by binding to pituitary somatostatin receptors, and may inhibit the release of various other hormones, including thyroid stimulating hormone (TSH) and the gastroenteropancreatic hormones insulin, glucagon and gastrin. This agent also decreases circulating total and free insulin-like growth factor 1 (IGF-I). Lanreotide exhibits a high binding affinity for somatostatin receptor 2 (SSTR-2) and a lesser binding affinity for SSTR-5. However, compared to octreotide, this agent is less potent in inhibiting the release of growth hormone from the pituitary gland. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65111\" active clinical trials using this agent.", + "output": "lanreotide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as femtograms per milliliter (concentration), divided by milligrams per meter squared per day (daily dose normalized by surface area).", + "output": "fg/ml/(mg/m2/d) (Quantitative Concept)" + }, + { + "input": "Definition: NADP binding described as interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.", + "output": "NADP (reduced) binding (NADP binding)" + }, + { + "input": "Definition: organonitrogen compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "output": "protein breakdown (Molecular Function)" + }, + { + "input": "Definition: Abnormal Finding described as the presence of red blood cells within hepatocytes of the liver parenchyma.", + "output": "INTRAHEPATOCELLUAR ERYTHROCYTES (Finding)" + }, + { + "input": "Definition: Cell Function described as any protein localization that is involved in auxin polar transport.", + "output": "establishment and maintenance of protein localization involved in auxin polar transport (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as a special-purpose domain that is designed to record the timing, for each subject, of disease milestones that have been defined in the Trial Disease Milestones (TM) domain.", + "output": "Subject Disease Milestones (Intellectual Product)" + }, + { + "input": "Definition: Formations described as a state of matter where particles form a stable, definite shape that can only change by force (e.g. break, cut).", + "output": "Solid (Qualitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 10 on a drowsiness scale that ranges from 0: No Drowsiness to 10: Worst Possible Drowsiness.", + "output": "Drowsiness Score 10 (Drowsiness Visual Analogue Scale)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as a colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.", + "output": "Ethyl Aldehyde (Organic Chemicals)" + }, + { + "input": "Definition: something described as large organic molecule with an internal space that is completely enclosed; also, a substance in which molecules of one compound are enclosed in cavities within another compound.", + "output": "clathrate (Organic Chemical)" + }, + { + "input": "Definition: Renal Pelvis and Ureter Cancer Pathologic Distant Metastasis TNM Finding v8 described as renal pelvis and ureter cancer with distant metastasis.", + "output": "Renal Pelvis and Ureter Cancer pM1 TNM Finding v8 (Renal Pelvis and Ureter Cancer Pathologic Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: something described as the process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.", + "output": "chaperone-mediated protein folding (protein folding)" + }, + { + "input": "Definition: Molecular Function described as combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.", + "output": "boss receptor activity (transmembrane receptor protein tyrosine kinase activity)" + }, + { + "input": "Definition: specific AODU measurement and test described as a 65-item self-report questionnaire that utilizes a 5-point Likert Scale rating system to assess an individual's mood state.", + "output": "Profile of Mood States Questionnaire (specific AODU measurement and test)" + }, + { + "input": "Definition: Natural Phenomenon or Process described as ultraviolet A Radiation is the 320 to 400 nanometers portion of the sun's radiant electromagnetic energy spectrum, partially absorbed by the Earth's protective stratospheric ozone layer. It is may be up to 1,000 times more intense than UVB. UVA radiation can penetrate to underlying tissues of the skin and cause photo-aging or long-term skin damage. Recent ozone depletion has permitted more UV radiation to reach the Earth's surface with a wide range of potentially damaging health effects related to skin, eyes, and immune system.", + "output": "UVA radiation (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Persons described as any person or entity that has a role or participates in a clinical research study, including both study personnel and study subjects.", + "output": "participant (Persons)" + }, + { + "input": "Definition: Adenosquamous carcinoma described as a carcinoma with glandular and squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.", + "output": "Ampulla of Vater Adenosquamous Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Abscess described as an abscess that is located in the spleen.", + "output": "spleen abscess (Abdominal visceral abscess)" + }, + { + "input": "Definition: type of day described as days commemorating events. Holidays also include vacation periods.", + "output": "holidays (Event)" + }, + { + "input": "Definition: Neoplastic Process described as stage 0 includes: pTis, N0, M0, S0. pTis: Intratubular germ cell neoplasia (carcinoma in situ). N0: regional lymph node metastasis. M0: No distant metastasis. S0: Marker study levels within normal limits. (AJCC 6th and 7th eds.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4523\" active clinical trials using this agent.", + "output": "Stage 0 Testicular Cancer AJCC v6 (Testicular Cancer by AJCC v6 and v7 Stage)" + }, + { + "input": "Definition: AIMS Clinical Classification Question described as abnormal Involuntary Movement Scale - Dental Status, Does patient usually wear dentures?", + "output": "AIMS0112 (Intellectual Product)" + }, + { + "input": "Definition: Body Space or Junction described as an opening in the transversalis fascia midway between the anterior superior iliac spine and pubic tubercle through which the spermatic cord (males) or round ligament (females) pass.", + "output": "Internal Abdominal Ring (Body Space or Junction)" + }, + { + "input": "Definition: something described as an abnormally reduced concentration of hepcidin in the blood circulation.", + "output": "Decreased hepcidin level (Abnormal hepcidin level)" + }, + { + "input": "Definition: Brain part described as the frontal aspect of the cistern of the corpus callosum.", + "output": "Anterior Portion of the Corpus Callosum Cistern (Brain part)" + }, + { + "input": "Definition: Skin injuries and mechanical dermatoses described as a bruise due to trauma.", + "output": "contusions (Skin)" + }, + { + "input": "Definition: Transducers, Pressure, Vascular Aneurysm described as transducers designed to convert pressure to ultrasound energy to measure the pressure in an aneurysm sac that is excluded from the blood circulation (usually in an area of thrombus) by a stent-graft implanted to repair the vascular aneurysm. The transducer works with an external unit including a handheld probe that makes contact with the skin to read the pressure from the transducer signal. These transducers are typically a hermetically sealed device that is fixed to the outside of the stent-graft; the transducer includes a piezoelectric membrane that charges a capacitor when energized by ultrasound waves from a handheld probe; once charged the transducer sends back an ultrasound signal to the external unit that varies according to the value of the pressure. Ultrasonic vascular aneurysm pressure measuring transducers, in combination with a matching external unit, are used during endovascular procedures intended to repair vascular aneurysms (typically abdominal aortic aneurysms); comparing the value of the pressure in the aneurysm sac before and after the exclusion of the sac from the blood circulation during the aneurysm repair procedure facilitates the detection of internal leaks.", + "output": "Vascular Aneurysm Ultrasound Pressure Transducers (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as a non-neoplastic disorder that affects the male or female reproductive system. Representative examples include prostatitis, balanitis, phimosis, endometriosis, and pelvic inflammatory disease.", + "output": "Non-Neoplastic Reproductive System Disorder (Non-Neoplastic Genitourinary System Disorder)" + }, + { + "input": "Definition: something described as a type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs. []", + "output": "Leg dystonia (Sign or Symptom)" + }, + { + "input": "Definition: Country described as an island in the Caribbean sea, between Anguilla and Saint Barthelemy.", + "output": "MAF (Geographic Area)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.", + "output": "cellular response to abiotic stimulus (Cell Function)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of transforming growth factor beta 2 present in a sample.", + "output": "TGF-Beta-2 Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Exercise Tolerance described as functions related to the general level of tolerance of physical exercise or stamina.", + "output": "General physical endurance (Exercise Tolerance)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; hemodynamic compromise", + "output": "Grade 4 Ventricular tachycardia (Ventricular Tachycardia, CTCAE 3.0)" + }, + { + "input": "Definition: Intellectual Product described as documentation tracking investigational product (IP) inventory returns to/from a distribution center, depot, and/or trial site. May include, but is not limited to, courier documentation and packing or inventory listing.", + "output": "IP Return Record (Records)" + }, + { + "input": "Definition: something described as the determination of the amount of transitional epithelial cells present in a urine sample.", + "output": "Transitional Epithelial Cells (Laboratory Procedure)" + }, + { + "input": "Definition: something described as country in the southwestern Pacific comprising chiefly North and South Islands; capital Wellington; a dominion of the British Commonwealth.", + "output": "NZL (Affiliate Realms)" + }, + { + "input": "Definition: Parenteral Iron Replacement described as a glucaric acid-iron conjugate that is used in the treatment of IRON-DEFICIENCY ANEMIA, including in patients with chronic kidney disease, when oral iron therapy is ineffective or impractical.", + "output": "Ferric Saccharate (Hematinics)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual has difficulty finding clothes to fit.", + "output": "Difficult to Find Clothes to Fit (Intellectual Product)" + }, + { + "input": "Definition: something described as auditory Verbal Learning Test Version A - List B, Word 7.", + "output": "ADNI AVLT - List B Recall Word 7 (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Upon administration, PARP inhibitor NMS-03305293 selectively binds to PARP and prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.", + "output": "NMS-03305293 (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons.", + "output": "medium-chain aliphatic aldehyde dehydrogenase activity (aldehyde dehydrogenase (NAD+) activity)" + }, + { + "input": "Definition: something described as a response indicating that an individual required help from another person to eat, bathe, dress, or use the toilet.", + "output": "Required Help to Eat, Bathe, Dress, or Use Toilet (Finding)" + }, + { + "input": "Definition: Disorder of soft tissue of lower limb described as disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions.", + "output": "disease (or disorder); nerve, sciatic (Disorder of thigh)" + }, + { + "input": "Definition: late pregnancy described as a gestation that lasts greater than or equal to 42 weeks and 0 days.", + "output": "PROLONGED PREGN (Pregnancy)" + }, + { + "input": "Definition: something described as a superordinate descriptor for one or more MedDRA preferred terms (PTs). It is subordinate to high level group term (HLGT).", + "output": "MedDRA High Level Term (Term)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as salmonella spp. serological reagents are devices that consist of antigens and antisera used in serological tests to identify Salmonella spp. from cultured isolates derived from clinical specimens. Additionally, some of these reagents consist of antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify Salmonella spp. directly from clinical specimens or cultured isolates derived from clinical specimens. The identification aids in the diagnosis of salmonellosis caused by bacteria belonging to the genus Salmonella and provides epidemiological information on this disease. Salmonellosis is characterized by high grade fever (``enteric fever''), severe diarrhea, and cramps.", + "output": "ANTIGENS, ALL GROUPS, SALMONELLA SPP. (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Genus staphylococcus described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for catalase and urease, and negative for coagulase and oxidase. It can ferment xylose, trehalose, arabinose, mannose, fructose, lactose, sucrose, turanose, and mannitol, but not maltose, turanose, cellobiose, or xylitol. S. xylosus is commensal on the skin of humans and animals, is used in the production of cheese and sausage and is a rare opportunistic pathogen in humans that can cause dermititis, urinary tract infections and bacteremia.", + "output": "Staphylococcus xylosus Schleifer and Kloos 1975 (Staphylococcus, coagulase negative)" + }, + { + "input": "Definition: something described as a polypeptide comprised of the amino-terminal portions of procollagen, which are proteolytically removed during the intracellular formation of type I collagen fibrils. Increased plasma or serum concentrations of these peptides are associated with both fibrillogenesis of type I collagen and bone formation.", + "output": "Amino-Terminal Propeptide of Type I Procollagen (Procollagen Type I)" + }, + { + "input": "Definition: Urinary Bladder described as lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible.", + "output": "Enuresis (Psychiatric elimination disorders)" + }, + { + "input": "Definition: C-SSRS Baseline/Screening Version Questionnaire Question described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Total number of attempts. (Lifetime).", + "output": "CSS04-Number of Actual Attempts-Life (C-SSRS Baseline/Screening Version Questionnaire Question)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 239 of the coding sequence of the PAX5 gene where cytosine has been mutated to guanine.", + "output": "Paired Box 5 c.239C>G (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Glycoprotein biosynthetic process described as the chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.", + "output": "CD86 anabolism (Glycoprotein biosynthetic process)" + }, + { + "input": "Definition: Adult Acute Monoblastic and Monocytic Leukemia described as an acute monocytic leukemia occurring in adults.", + "output": "Adult Acute Monocytic Leukemia (M5b Acute differentiated monocytic leukemia)" + }, + { + "input": "Definition: something described as mini-Mental State Examination - Please write a sentence.", + "output": "MMS1-Write a Sentence (Intellectual Product)" + }, + { + "input": "Definition: Eukaryote described as class in the phylum Cnidaria which alternates between polyp and medusa forms during their life cycle; there are over 2700 species in five orders.", + "output": "731 CLASS HYDROZOA (Eukaryote)" + }, + { + "input": "Definition: Transduction Gene described as a recombinant engineered chimeric gene derived from the murine gene encoding the variable region of monoclonal antibody MOv18 against folate-binding protein, which is often overexpressed in human ovarian cancer cells, and the gene encoding the Fc receptor for the gamma subunit of human IgG and IgE. Peripheral blood lymphocytes expressing the MOv-gamma gene may be used in the immunotherapeutic treatment of ovarian cancer.", + "output": "MOv-gamma (Gene or Genome)" + }, + { + "input": "Definition: Professional or Occupational Group described as a preventive medicine physician who specializes in the diagnosis and treatment of sports related conditions and injuries.", + "output": "Preventive Medicine - Sports Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Pharmacologic Substance described as extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.", + "output": "Pancreatic Extracts (Tissue Extracts)" + }, + { + "input": "Definition: regulation of mononuclear cell proliferation described as any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.", + "output": "negative regulation of mononuclear cell proliferation (negative regulation of leukocyte proliferation)" + }, + { + "input": "Definition: Erythema described as chronic form of cutaneous lupus erythematosus in which the skin lesions mimic those of the systemic form but in which systemic signs are rare; characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy; lesions are surrounded by an elevated erythematous border; the condition typically involves the face and scalp, but widespread dissemination may occur.", + "output": "Discoid lupus rash (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as patient Health Questionnaire Screener Version - Over the last 4 weeks, how often have you been bothered by trouble falling asleep or staying asleep?", + "output": "PHQ0305E (PHQ Screener Version Questionnaire Question)" + }, + { + "input": "Definition: Eponymic Fractures and Dislocations described as fracture in the proximal half of the shaft of the ulna, with dislocation of the head of the radius.", + "output": "monteggia's fracture (SPECIFIC DISLOCATIONS)" + }, + { + "input": "Definition: Gene or Genome described as human ITGA10 wild-type allele is located in the vicinity of 1q21.1 and is approximately 19 kb in length. This allele, which encodes integrin alpha-10 protein, is involved in cell-matrix adhesion.", + "output": "Integrin, Alpha 10 Gene (ITGA10 gene)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production.", + "output": "down regulation of interleukin-19 production (negative regulation of cytokine production)" + }, + { + "input": "Definition: Benign neoplasm of breast described as a benign, nodular tumor that arises from the breast parenchyma. It is characterized by the proliferation of myoepithelial cells around spaces that are lined by epithelial cells. Occasionally, adenomyoepitheliomas may undergo malignant transformation.", + "output": "Benign Adenomyoepithelioma of the Breast (Benign neoplasm of breast)" + }, + { + "input": "Definition: Pharyngeal Carcinoma by AJCC v6 Stage described as a term that refers to the staging of oropharyngeal carcinoma according to the American Joint Committee on Cancer, 6th edition.", + "output": "Oropharyngeal Carcinoma by AJCC v6 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Cyst of gallbladder described as the enlargement of the gallbladder secondary to prolonged obstruction of the cystic duct.", + "output": "Mucocele of gallbladder (diseases of the gallbladder and bile ducts)" + }, + { + "input": "Definition: Sequence Number described as a number that identifies the ordering relations (in time, space, etc.) in a set of drug accountability data.", + "output": "DASEQ (Sequence Number)" + }, + { + "input": "Definition: something described as societies whose membership is limited to nurses.", + "output": "Societies, Nursing (Societies)" + }, + { + "input": "Definition: Chemopreventive Agent described as a bioadhesive gel containing 10% freeze-dried black raspberries (FBR) with potential chemopreventive and antioxidant activities. The four main constituent black raspberry anthocyanins that contribute significantly to the chemopreventive effects are cyanidin 3-glucoside (C3GLU), cyanidin 3-rutinoside (C3RUT), cyanidin 3-sambubioside (C3SAM) and cyanidin 3-(2(G)-xylosyl) rutinoside (C3XRUT). Upon mucosal application, the anthocyanins from the gel penetrate the oral mucosa and are able to modulate expression of certain proapoptotic and terminal differentiation genes, and reduce the expression of epithelial cyclooxygenase-2 (COX-2) protein. In addition, this gel may also reduce vascular densities in the superficial connective tissues. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95770\" active clinical trials using this agent.", + "output": "freeze-dried black raspberry bioadhesive gel (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as the pickled flower buds of CAPPARIS.", + "output": "Caper (Seasoning)" + }, + { + "input": "Definition: Mammal described as an exceptionally intelligent and lively dog that is devoted to the shepherd and herd and is an excellent companion, sporting dog, and guard dog. Its hair is long and shaggy and may be a variety of colors. The average height range is 16.5-21.5 inches and the average weight range is 37.5-59 pounds.", + "output": "Portuguese Sheepdog (Herding Breed)" + }, + { + "input": "Definition: Surgical implantation - action described as a surgical procedure that places something in the body that was previously lost or removed.", + "output": "replacement (Therapeutic Surgical Procedure)" + }, + { + "input": "Definition: Microbiological Phenomena described as physiological processes and properties of BACTERIA.", + "output": "Physiology, Bacterial (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Immunologic Factor described as a radioimmunoconjugate of a murine monoclonal antibody, MoAb Lym-1, labeled with iodine 131 (I-131). MoAb Lym-1 recognizes an epitope of the histocompatibility antigen HLA-DR, which is over-expressed on most B-cell lymphomas. I-131 MoAb Lym-1 delivers beta and gamma radiation emitting I-131 nuclide directly to tumor cells that express HLA-DR, thereby allowing imaging and/or treatment of cancers.", + "output": "iodine I 131 monoclonal antibody Lym-1 (Radioimmunoconjugates)" + }, + { + "input": "Definition: something described as the determination of the amount of free and bound triiodothyronine present in a sample.", + "output": "Triiodothyronine measurement (Thyroid Function Tests)" + }, + { + "input": "Definition: furuncle described as a skin condition that is characterized by recurring furuncles, lesions primarily caused by staphylococcus aureus infection of the hair follicles and surrounding skin. Furunculosis occurs more frequently in persons with immune systems disorders than in the general population.", + "output": "Forunculosis (Skin Diseases, Infectious)" + }, + { + "input": "Definition: Carcinoma of lung described as a term that refers to the staging of lung carcinoma according to the American Joint Committee on Cancer, 7th edition.", + "output": "Lung Cancer by AJCC v7 Stage (Carcinoma of lung)" + }, + { + "input": "Definition: teichoic acid biosynthetic process described as the formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid.", + "output": "teichoic acid D-alanylation (Molecular Function)" + }, + { + "input": "Definition: something described as a focal cognitive seizure characterized by hallucination as the initial semiological manifestation.", + "output": "Hallucinatory aura (Disease or Syndrome)" + }, + { + "input": "Definition: Bodywork described as teaching a family member(s) how to apply alternating and firm pressure to another family member's(s') feet, hands and/or ears to stimulate physiological changes in his or her body through reflexes and the nervous system. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.", + "output": "Reflexology instruction family each 15 minutes (Health Care Activity)" + }, + { + "input": "Definition: something described as a standardized questionnaire developed by Galasko et al in 1997 as part of the Alzheimer's disease cooperative study, which is used to measure the performance of activities of daily living by patients diagnosed with Alzheimer's disease, exhibiting evidence of mild cognitive impairment (MCI). The questionnaire contains 24 items (and a number of sub-items within the 24 main items) with a range of preset answers that are assigned points based on performance.", + "output": "ADCS-ADL MCI (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as a shoulder joint metal/polymer/metal nonconstrained or semi-constrained porous-coated uncemented prosthesis is a device intended to be implanted to replace a shoulder joint. The", + "output": "PROSTHESIS, SHOULDER, SEMI-CONSTRAINED, METAL/POLYMER, UNCEMENTED (Medical Device)" + }, + { + "input": "Definition: Cell Function described as the process by which centromeres/kinetochores become localized to clusters.", + "output": "centromere clustering (centromere localization)" + }, + { + "input": "Definition: Molecular Function described as the linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine.", + "output": "protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine (peptidyl-cysteine modification)" + }, + { + "input": "Definition: Organic Chemical described as an antiseptic agent with potential antibacterial and antileukemic activity. Although the exact mechanism of action remains to be fully elucidated, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity. Furthermore, this agent's affinity for various cellular targets, i.e. membranes, nucleic acids and proteins, may contribute to the overall antibacterial effect.", + "output": "p-Benzoquinone Amidinohydrazone Thiosemicarbazone (Antiseptic throat preparations)" + }, + { + "input": "Definition: ketone biosynthetic process described as the chemical reactions and pathways resulting in the formation of quinone.", + "output": "quinone biosynthesis (coenzyme biosynthetic process)" + }, + { + "input": "Definition: something described as reduced ability affecting mainly visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales, which test a person's strengths and weaknesses across a range of intellectual abilities).", + "output": "Impaired visuospatial constructive cognition (Finding)" + }, + { + "input": "Definition: Quantitative Concept described as an identifier that describes the relative position of healthcare encounters data within a series.", + "output": "HOSEQ (Sequence Number)" + }, + { + "input": "Definition: something described as neuromuscular function physiologic analyzers designed to evaluate several biological measures (i.e., biomarkers) that assess biological states that are essential for activities of daily living, thus characterizing the functional age of a person. The analyzers evaluate both neurologic (e.g., memory, reaction times) and physical conditions (e.g., hearing, vision, tactile, lung functions) and compare the results with standard values from healthy people adjusted for sex and age to show the biomarkers' decline in a given person. The set of biomarkers (typically about 12) chosen is related to those conditions that are involved in mental and physical activities that better characterize normal day-to-day living. These analyzers typically consist of a set of measuring instruments and transducers (e.g., headphones, lenses, vibrometers, spirometers) and a panel with push buttons to evaluate the physiologic parameters and reaction times. The analyzer also includes a computer with appropriate software to calculate and provide the results including a value of the functional age for comparison with the chronological age. Functional-age physiologic analyzers are used to assess the status of a person, facilitating the development of programs for lifestyle, diet, exercise, and/or other therapeutic (e.g., use of assistive devices) actions needed to improve daily living of aging people.", + "output": "Analyzers, Physiologic, Neuromuscular Function, Functional Age (Medical Device)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of cellular response to gamma radiation.", + "output": "regulation of cellular response to gamma radiation (regulation of cellular process)" + }, + { + "input": "Definition: Glomus Tumor described as a glomus tumor that shows atypical characteristics and has borderline malignant potential.", + "output": "Glomus Tumor of Uncertain Malignant Potential (Neoplastic disease of uncertain behavior)" + }, + { + "input": "Definition: Laboratory or Test Result described as a laboratory finding indicating that the subject expresses abnormal hemoglobin containing 2 variant forms of the hemoglobin subunit beta protein (HBB). One HBB protein variant has the amino acid substitution glutamic acid to valine at residue 6, which is associated with the formation of hemoglobin S (HbS), while the other variant has a glutamic acid to lysine substitution at residue 121, which is associated with the formation of hemoglobin O-Arab (HbO(Arab)). Subjects expressing this compound heterozygous HBB genotype may have severe sickling hemoglobinopathy with clinical manifestations similar to those of homozygous sickle cell anemia.", + "output": "Hb S/O(Arab) (Laboratory or Test Result)" + }, + { + "input": "Definition: protein activation cascade described as a protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.", + "output": "blood coagulation, intrinsic pathway (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as artificial pacemakers with implantable leads to be placed in the RIGHT ATRIUM and both HEART VENTRICLES. They are used to treat various cardiac conduction disturbances which interfere with the timing of contraction of the ventricles.", + "output": "Biventricular Pacemaker, Artificial (Medical Device)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Multisystem Disorder, Bardet-Biedl Syndrome described as molecular assay reagents intended to identify deletions and duplications in genes associated with Bardet-Biedl syndrome, a multisystem disorder characterized by vision loss, obesity, and additional signs and symptoms affecting other parts of the body. Genetic variants at multiple loci have been associated with Bardet-Biedl syndrome. These reagents are intended to detect deletions and duplications in multiple Bardet-Biedl syndrome-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Multisystem Disorder, Bardet-Biedl Syndrome, Del/Dup (Medical Device)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a structure in the rat that emerges caudally from between the habenular commissure and the posterior commissure to connect with the pineal gland ( Swanson-2004 ).", + "output": "PIS (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.", + "output": "Bcl3/NF-kappaB2 complex (Cell Component)" + }, + { + "input": "Definition: Cell Adhesion Molecules described as integrin beta-4 (1822 aa, ~202 kDa) is encoded by the human ITGB4 gene. This protein is involved in epithelial cell adhesion.", + "output": "CD104 Antigen (Cell Adhesion Molecules)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in genes associated with Stargardt disease, a form of macular dystrophy typically characterized by the accumulation of lipofuscin in cells underlying the macula, which leads to progressive central and night vision loss. Genetic variants at multiple loci have been associated with Stargardt disease. These reagents are intended to detect mutations in multiple Stargardt disease-associated loci simultaneously.", + "output": "Stargardt Disease Gene Mutation Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Colorectal Neuroendocrine Tumor by AJCC v8 Stage described as stage IIA includes: T2, N0, M0. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IIA Colorectal Neuroendocrine Tumor AJCC v8 (Colorectal Neuroendocrine Tumor by AJCC v8 Stage)" + }, + { + "input": "Definition: Respiration molecular described as the air that is inhaled and exhaled during respiration.", + "output": "Respiratory air (Body Substance)" + }, + { + "input": "Definition: regulation of epithelial cell differentiation described as any process that modulates the frequency, rate or extent of hepatocyte differentiation.", + "output": "regulation of hepatocyte differentiation (Cell Function)" + }, + { + "input": "Definition: aromatic amino acid family biosynthetic process described as the chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.", + "output": "tryptophan synthesis (alpha-amino acid biosynthetic process)" + }, + { + "input": "Definition: Intellectual Product described as test names of functional test questions associated with the Brief Assessment of Cognition in Schizophrenia (BACS) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "CDISC Functional Test BACS Test Name Terminology (CDISC Functional Test Terminology)" + }, + { + "input": "Definition: Nervous System Disorders, CTCAE described as a disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.", + "output": "Guillain-Barre syndrome (Nervous System Disorders, CTCAE)" + }, + { + "input": "Definition: Genus Solobacterium described as any bacterial organism that can be assigned to the species Solobacterium moorei.", + "output": "Solobacterium moorei Kageyama and Benno 2000 (Genus Solobacterium)" + }, + { + "input": "Definition: something described as time the procedure is begun.", + "output": "Procedure start time (surgery times [use onset])" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally bioavailable citrate salt form of TG02, a multi-kinase inhibitor for cyclin dependent kinase (CDK) subtypes 1, 2, 7 and 9, Janus-associated kinase 2 (JAK2), FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon oral administration, CDK/JAK2/FLT3 Inhibitor TG02 binds to and inhibits the CDK subtypes, JAK2, and FLT3. TG02 also inhibits, to a lesser extent, TYK2, TYRO3, STAT5 and P38delta. This may result in both an induction of apoptosis and an inhibition of tumor cell proliferation in cancer cells that overexpress these kinases. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. CDKs are serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias.", + "output": "CDK/JAK2/FLT3 Inhibitor TG02 Citrate (Pharmacologic Substance)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a severity result of two, on a three level scale.", + "output": "2 OF 3 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Reference ID described as the reference identifier by which the study is known to the sponsor. This may be different from the STUDYID if the data were collected under a different identifier in the GLP protocol (e.g., used in a situation where a contract facility performs the study and provides a final report).", + "output": "SPREFID (Reference ID)" + }, + { + "input": "Definition: something described as an idiopathic condition in which the bladder and bladder outlet are normal but the ureter is dilated to some extent. It may be obstructed, refluxing or unobstructed and not refluxing. Prevalence is unknown, but is the second most common cause of neonatal hydronephrosis. About half of cases are asymptomatic and are discovered on routine antenatal ultrasound. The cause is unknown but it may be due to high fetal urine outflow, changes in the ureter pre and postnatal or transient anatomical obstructions that improve with postnatal development, such as ureteral folds. Not known to be hereditary, but families with more than one affected member have been described.", + "output": "Congenital primary megalo-ureter (Congenital Abnormality)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Additional Concerns: My mouth is dry.", + "output": "FAC015-My Mouth Is Dry (FACT-HEP Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Diagnostic Procedure described as the volume of air that can be forcibly exhaled during the first three seconds following maximal inhalation.", + "output": "FEV3 (Diagnostic Procedure)" + }, + { + "input": "Definition: Analyzers, Physiologic described as physiologic analyzers designed to determine gastric accommodation and/or peristaltic motility in some part of the gastrointestinal (GI) tract, including the esophagus, stomach, and the small and/or large intestines. These analyzers typically consist of catheters with one or more balloons that are inflated and/or deflated to maintain constant pressure inside the GI tract and an external electronic unit that regulates the balloon pressure by providing insufflation through the catheter, monitors the balloon pressure, displays and/or records the results, and processes the data to assess the accommodation response and/or motility of the GI tract segment. Barostatic GI analyzers are intended for the determination of pressure, motility, accommodation, sensations, and pain thresholds in a section of the GI tract (e.g., colon) and to evaluate several conditions and/or diseases in the stomach and small intestine, such as proximal gastric motility and accommodation response after meals.", + "output": "Gastric Accommodation Analyzers (Medical Device)" + }, + { + "input": "Definition: Cell Count described as the determination of the amount of leukocytes, which has been corrected for nucleated erythrocytes, present in a sample.", + "output": "Leuks Corrected for Nucl Erythrocytes (White Blood Cell Count procedure)" + }, + { + "input": "Definition: something described as the Short Form 36 (SF-36) Health Survey Standard, US Version 1.0 (SF36 v1.0 Standard) Question 3d.", + "output": "SF36 v1.0 Standard - Question 3d (Intellectual Product)" + }, + { + "input": "Definition: Endocrine System Diseases described as an acute or chronic inflammatory process affecting a salivary gland. Signs and symptoms include pain and tenderness in the affected area.", + "output": "sialadenitis (Inflammatory disorder of digestive system)" + }, + { + "input": "Definition: MAPK13 gene described as human MAPK13 wild-type allele is located in the vicinity of 6p21.31 and is approximately 86 kb in length. This allele, which encodes mitogen-activated protein kinase 13 protein, plays a role in the regulation of protein translation and cellular signaling in response to environmental stress or pro-inflammatory cytokines.", + "output": "SAPK4 (MAPK13 gene)" + }, + { + "input": "Definition: peptide hormone described as a 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.", + "output": "APJ endogenous ligand (peptide hormone)" + }, + { + "input": "Definition: Negative Diagnosis And Outcome described as change in or modification of the heart or blood vessels", + "output": "Cardiovascular system alteration (Finding)" + }, + { + "input": "Definition: transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide.", + "output": "chalcone synthase activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as clone negative. Note: A T-cell clone is defined by PCR or Southern blot analysis of the T-cell receptor gene.", + "output": "Mycosis Fungoides and Sezary Syndrome N2a TNM Finding v7 (Mycosis Fungoides and Sezary Syndrome N2 TNM Finding v7)" + }, + { + "input": "Definition: Biologically Active Substance described as protein RRP5 homolog (1871 aa, ~209 kDa) is encoded by the human PDCD11 gene. This protein is involved in rRNA biosynthesis.", + "output": "Protein RRP5 Homolog (Translation Process Protein)" + }, + { + "input": "Definition: Published Comment described as an optional additional description of an activity that can be planned, scheduled or performed in the framework of a particular study. The comment is provided in a free text format.", + "output": "Comment on Study Activity (Published Comment)" + }, + { + "input": "Definition: accident environment described as unforeseen occurrences, especially injuries in the course of work-related activities.", + "output": "Occupational Accident (Accidents)" + }, + { + "input": "Definition: Hamartosis, NOS described as an autosomal dominant disorder defined by the presence of multiple dysplastic nevi and a history of melanoma in two family members. Patients are at an increased risk for the development of melanoma.", + "output": "B-K mole (nevus) syndrome (disorder) [Ambiguous] (Hamartosis, NOS)" + }, + { + "input": "Definition: Nature of procedure values described as having to do with treating disease and helping healing take place.", + "output": "therapeutic (Purpose)" + }, + { + "input": "Definition: something described as leukemia in which the involved cell is well differentiated, usually B-lymphocytes, but immunologically incompetent; types distinguished include chronic granulocytic, chronic lymphocytic, chronic myelomonocytic, eosinophilic and hairy cell leukemia.", + "output": "chronic leukemias (leukemia)" + }, + { + "input": "Definition: Motivation described as a state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.", + "output": "drive [mental process] (Motivation)" + }, + { + "input": "Definition: cranial nerve morphogenesis described as the process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.", + "output": "CN VII morphogenesis (Organism Function)" + }, + { + "input": "Definition: dexamethasone described as a topical combination preparation containing the sulfate salt form of the aminoglycoside antibiotic neomycin, the sulfate salt form of the polypeptide antibiotic polymyxin B, and the glucocorticoid dexamethasone, with antimicrobial, anti-infective and anti-inflammatory activities. Upon topical application, neomycin irreversibly binds to the bacterial 30S ribosomal subunit, thereby preventing mRNA from binding, causing both misreading and the inhibition of protein synthesis. Polymyxin B binds, with its positively charged amino groups, to negatively charged phospholipids in the outer cell membrane of Gram-negative bacteria, thereby disrupting cell wall integrity and altering the permeability of the bacterial cytoplasmic membrane. Dexamethasone binds to the cytoplasmic glucocorticoid receptor, and this receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins.", + "output": "Neomycin Sulfate/Polymyxin B Sulfate/Dexamethasone (dexamethasone Ophthalmic Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in brain development.", + "output": "FORKHEAD BOX P2 (Transcription factor genes)" + }, + { + "input": "Definition: Thermometer, device described as a clinical color change thermometer is a disposable device used to measure a patient's oral, rectal, or axillary (armpit) body temperature. The device records body temperature by use of heat sensitive chemicals which are sealed at the end of a plastic or metal strip. Body heat causes a stable color change in the heat sensitive chemicals.", + "output": "THERMOMETER, CLINICAL COLOR CHANGE (Medical Device)" + }, + { + "input": "Definition: Translation Process Gene described as this gene plays a role in the regulation of both ubiquitination and translation.", + "output": "aminoacyl tRNA synthetase complex interacting multifunctional protein 2 (Gene or Genome)" + }, + { + "input": "Definition: something described as a deep type of gyrate erythema that follows a bite by an ixodid tick; it is a stage-1 manifestation of LYME DISEASE. The site of the bite is characterized by a red papule that expands peripherally as a nonscaling, palpable band that clears centrally. This condition is often associated with systemic symptoms such as chills, fever, headache, malaise, nausea, vomiting, fatigue, backache, and stiff neck.", + "output": "erythema; chronicum migrans (Skin Diseases, Parasitic)" + }, + { + "input": "Definition: Pyruvate Metabolism Pathway described as the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.", + "output": "acetyl-CoA synthesis from pyruvate (acetyl-CoA biosynthetic process)" + }, + { + "input": "Definition: Skin/Wound Management described as palliative care and prevention of complications of a malignant or other wound that is not expected to heal", + "output": "Wound Care: Nonhealing (Skin/Wound Management)" + }, + { + "input": "Definition: Volume of Distribution for Dosing Interval described as the volume of distribution associated with the terminal slope following extravascular administration divided by the fraction of dose absorbed, calculated using AUCTAU, divided by the body mass index.", + "output": "VZFTAUB (Volume of Distribution for Dosing Interval)" + }, + { + "input": "Definition: Intellectual Product described as a question about the average time per week that an individual spent on a specific activity.", + "output": "During the past year, what was your average time per week spent at each of the following recreational activities (Intellectual Product)" + }, + { + "input": "Definition: Long Intergenic Non-Protein Coding RNA described as long noncoding RNA KIAA0125 (~10 kb) is encoded by the human FAM30A gene. This non-coding RNA may be involved in the modulation of both cell migration and epithelial-mesenchymal transition.", + "output": "Family With Sequence Similarity 30, Member A, Long Non-Coding RNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Abnormality of the urethra described as the presence of a diverticulum (sac or pouch) in the wall of the urethra.", + "output": "urethral diverticulum (Other disorders of urethra and urinary tract)" + }, + { + "input": "Definition: something described as a plant genus of the family HYDROPHYLLACEAE that has a characteristic strong smell.", + "output": "Eriodictyon Benth., 1844 (Hydrophyllaceae)" + }, + { + "input": "Definition: Finding described as a deviation from the normal concentration of properdin in the blood.", + "output": "Abnormal circulating properdin level (Finding)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of a xyloglucan.", + "output": "xyloglucan catabolic process (hemicellulose catabolic process)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.", + "output": "negative regulation of endothelial cell chemotaxis (negative regulation of endothelial cell migration)" + }, + { + "input": "Definition: Finding described as regional lymph nodes cannot be assessed.", + "output": "Adrenal Cortical Carcinoma pNX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Classification described as this SMQ is a sub-SMQ of Drug related hepatic disorders - comprehensive search (SMQ), which is itself a sub-SMQ of Hepatic disorder (SMQ). For detailed description, please refer to the one in Hepatic disorder (SMQ).", + "output": "Cholestasis and jaundice of hepatic origin (Classification)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 1966 of the coding sequence of the FGFR1 gene where adenine has been mutated to guanine.", + "output": "N-SAM c.1966A>G (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: influenza A virus described as a subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 7. The H7N7 subtype produced an epidemic in 2003 which was highly pathogenic among domestic birds (POULTRY). Some infections in humans were reported.", + "output": "Virus, H7N7 (Influenza A virus subtype H7)" + }, + { + "input": "Definition: Self related adjustment AND/OR maladjustment described as disorder characterized by the development of anxiety and dissociative symptoms as a result of exposure to a traumatic event. Symptoms last at least two days and no longer than four weeks.", + "output": "Unspecified acute reaction to stress (Reaction to severe stress, and adjustment disorders)" + }, + { + "input": "Definition: Chimeric Antigen Receptor T-cells described as a preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B cell maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities. Upon administration, BCMA-specific CAR-expressing T-lymphocytes specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand and B-cell activating factor, is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C117729\" active clinical trials using this agent.", + "output": "Anti-BCMA CAR T Cells BB2121 (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as administering an injection without a specific allergen extract(s) to a client/patient to alleviate his or her allergic reaction(s). Use BEBAE in conjunction with BEBAC. Service is billed per injection.", + "output": "alrg njxn W/Oxtrct prvsn ea. (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a rare benign adipose tissue neoplasm of the central nervous system frequently found in midline locations such as the corpus callosum, the quadrigeminal plate, the hypothalamus, the spinal canal or the cauda equina. Some contain Schwann cells, bone, cartilage or hamartomatous blood vessels.", + "output": "Lipoma of the CNS (Neoplastic Process)" + }, + { + "input": "Definition: Medical Device described as an ophthalmic camera is an AC-powered device intended to take photographs of the eye and the surrounding area.", + "output": "Refractometers, Ophthalmologic (Ophthalmological Equipment and Supplies)" + }, + { + "input": "Definition: something described as this gene plays a role in bone formation via regulation of osteoblast differentiation. It is also involved in cell cycle regulation.", + "output": "BMP2A (Bone Morphogenetic Protein Gene)" + }, + { + "input": "Definition: Finding described as an elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism. []", + "output": "High urinary gonadotropin level (Abnormal urine hormone level)" + }, + { + "input": "Definition: something described as a republic in southern Africa, between NAMIBIA and ZAMBIA. It was formerly called Bechuanaland. Its capital is Gaborone. The Kalahari Desert is in the west and southwest.", + "output": "Bechuanaland (Africa, Southern)" + }, + { + "input": "Definition: chemical substances by structure described as a substance whose atoms all have the same atomic number, that cannot be divided into simpler substances, and that singly or in combination constitute all matter.", + "output": "Chemical element (Element, Ion, or Isotope)" + }, + { + "input": "Definition: Organic Chemical described as picrate of zinc.", + "output": "zincum picricum/zinc picrate (Homeopathic remedies letter Z)" + }, + { + "input": "Definition: Qualitative Concept described as company defined.", + "output": "Proprietary Storage Condition (Qualitative Concept)" + }, + { + "input": "Definition: Fusion Gene described as a fusion gene that results from a chromosomal translocation t(5;17)(q33;p13) which fuses most of the RABEP1 gene with the 3' part of the PDGFRB gene. This gene fusion is associated with chronic myelomonocytic leukemia.", + "output": "RABEP1/PDGFRB FUSION GENE (Fusion Gene)" + }, + { + "input": "Definition: something described as conforming to facts, reality or definitive criteria.", + "output": "True (General Qualifier)" + }, + { + "input": "Definition: Cytoplasmic Filaments described as a class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules.", + "output": "Intermediate filament (Cytoplasmic Filaments)" + }, + { + "input": "Definition: Organ system subdivision described as the framework that supports the soft tissues of vertebrate animals and protects many of their internal organs. The skeletons of vertebrates are made of bone and/or cartilage.", + "output": "Skeletal system, NOS (Skeletal bone)" + }, + { + "input": "Definition: Poxviridae described as a poxvirus of the genus Avipoxvirus. Has been adapted as a cloning vector (canarypox vector) for use as a mammalian expression vector.", + "output": "Avipoxvirus clade B1 (Virus)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has recovered their ability to do daily activities as expected.", + "output": "Recovered Ability to do Daily Activities as Expected (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a rare hereditary syndromic intellectual disability characterized by cognitive impairment, behavioral and psychiatric problems, recurrent infections, atopic diseases and distinctive facial features in males. Females are clinically asymptomatic or mildly affected presenting mild learning difficulties and facial dysmorphism.", + "output": "Distal Xq28 microduplication syndrome (Anomaly of chromosome X)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated", + "output": "Grade 4 Rash Acneiform, CTCAE (Finding)" + }, + { + "input": "Definition: Endocrine finding described as an abnormality in the biochemical pathway involving the melanocortins, a group of peptide hormones associated with anorexogenic signaling in the brain stem and hypothalamus.", + "output": "Melanocortin Pathway Defects (Endocrine finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that something occurs rarely or with very little intensity.", + "output": "Hardly at all (Finding)" + }, + { + "input": "Definition: Serine/Threonine Kinase Inhibitor described as an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase, with potential antineoplastic activity. Upon administration, empesertib binds to and inhibits the activity of Mps1. This causes inactivation of the spindle assembly checkpoint (SAC), accelerated mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increased aneuploidy. This leads to the induction of cell death in cancer cells overexpressing Mps1. Mps1, a kinase expressed in proliferating normal tissues and aberrantly overexpressed in a wide range of human tumors, is activated during mitosis and is essential for SAC functioning and controls chromosome alignment.", + "output": "Empesertib (Pharmacologic Substance)" + }, + { + "input": "Definition: Bodily secretions described as the digestive secretions of the gastric glands in the stomach, consisting mainly of pepsin, hydrochloric acid, rennin, and mucin.", + "output": "gastric juice (Body Fluids)" + }, + { + "input": "Definition: something described as group of disorders characterized by delays in the development of socialization and communication skills; typical age of onset is before 3 years of age; symptoms may include problems with using and understanding language; difficulty relating to people, objects, and events; unusual play with toys and other objects; difficulty with changes in routine or familiar surroundings, and repetitive body movements or behavior patterns; AUTISM is the most characteristic and best studied PDD; other types of PDD include ASPERGER SYNDROME, Childhood Disintegrative Disorder, and RETT SYNDROME; prefer NTs where possible.", + "output": "pervasive developmental disorder (Pervasive Development Disorder)" + }, + { + "input": "Definition: Mental Process described as the state of being alert, oriented, and responsive to the environment.", + "output": "Conscious (Conscious)" + }, + { + "input": "Definition: Medical Device described as imageless stereotactic computer-aided surgical systems designed to aid in the performance of minimally invasive orthopedic procedures. These systems use a navigation system that is not guided by images (i.e., imageless) but by registering and tracking appropriate anatomic reference points (i.e., landmarks). Orthopedic imageless systems provide surgeons with real-time, three-dimensional (3-D) positioning and orientation of surgical instruments relative to the patient's anatomy similar to the systems that use image-guiding. These systems also provide surgical guidance without the need for pre- or intra-operative image acquisition, though registration is still necessary. Navigation is achieved by selecting specific anatomical parts or bone-implanted tracker pins intra-operatively as landmarks and using a reference pointer to create a reference frame for the computer model. Orthopedic imageless stereotactic surgery systems are used in several surgical procedures, including knee and hip arthroplasty; some systems include software capabilities to make possible imageless spinal trauma procedures.", + "output": "Stereotactic Systems, Imageless, Surgical, Orthopedic (Stereotactic Systems, Imageless, Surgical)" + }, + { + "input": "Definition: Molecular Function described as the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.", + "output": "ATP synthesis coupled electron transport (respiratory electron transport chain process)" + }, + { + "input": "Definition: Gene or Genome described as fungal genes that mostly encode TRANSCRIPTION FACTORS. In some FUNGI they also encode PHEROMONES and PHEROMONE RECEPTORS. The transcription factors control expression of specific proteins that give a cell its mating identity. Opposite mating type identities are required for mating.", + "output": "Gene, Fungal Mating-Type (Genes, Fungal)" + }, + { + "input": "Definition: Neoplastic Process described as a usually benign tumor made up predominantly of myoepithelial cells.", + "output": "Tumor, Myoepithelial (Neoplastic Process)" + }, + { + "input": "Definition: Functions and Abnormal Functions Associated with the Reproductive State described as the FERTILIZATION of an OVUM that takes place when a FETUS is already present in the UTERUS. Superfetation results in an unusual PREGNANCY with fetuses of different ages and sizes developing in utero simultaneously.", + "output": "superfetation (Organism Function)" + }, + { + "input": "Definition: Blood described as a type of immune cell that is made in the bone marrow and is found in the blood and in lymph tissue. The two main types of lymphocytes are B lymphocytes and T lymphocytes. B lymphocytes make antibodies, and T lymphocytes help kill tumor cells and help control immune responses. A lymphocyte is a type of white blood cell.", + "output": "Lymphocyte, NOS (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 5p", + "output": "5p13.2 (Chromosome band)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Was the Behavioral Assessment information obtained from.", + "output": "UHDRS 1999 Version - Behavior Assessment Obtained From (Intellectual Product)" + }, + { + "input": "Definition: positive regulation of ergot alkaloid biosynthetic process described as any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process.", + "output": "activation of chanoclavine-I aldehyde biosynthesis (positive regulation of ergot alkaloid biosynthetic process)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in androgen receptor function.", + "output": "Melanoma Antigen Family A, 11 Gene (Genes, Regulator)" + }, + { + "input": "Definition: G protein-coupled receptor binding described as interacting selectively and non-covalently with a metabotropic serotonin receptor.", + "output": "G-protein coupled serotonin receptor binding (G protein-coupled receptor binding)" + }, + { + "input": "Definition: Biogenic Amine Metabolic Process described as the chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "output": "biogenic amine biosynthesis (amine biosynthetic process)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally available, dietary supplement consisting of lyophilized blueberry powder, with antioxidant and potential chemopreventive and chemosensitizing activity. In addition to vitamins and minerals, blueberries are rich in phytonutrients, such as proanthocyanidins, anthocyanins (e.g. malvidin, delphinidin, pelargonidin, cyanidin, petunidin, and peonidin), hydroxycinnamic acids, hydroxybenzoic acids, pterostilbene, resveratrol, and flavonols (e.g. kaempferol, quercetin and myricetin). Although the exact mechanism of action through which blueberries may exert their anti-tumor effect has yet to be fully elucidated, the effects of blueberry powder on cancer cells may be attributable to the phytonutrient's antioxidant and pro-apoptotic activities.", + "output": "Blueberry Powder Supplement (Pharmacologic Substance)" + }, + { + "input": "Definition: Laboratory Procedure described as a method that detects the presence and reaction of complement-fixing alloantibodies to donor lymphocytes, via the addition of complement proteins and lysis of the lymphocytes.", + "output": "Complement-dependent Lymphocytotoxicity Assay (Laboratory Procedure)" + }, + { + "input": "Definition: Idea or Concept described as the obligations and accountability assumed in carrying out actions or ideas on behalf of others.", + "output": "social responsibilities (group behavior)" + }, + { + "input": "Definition: Disease or Syndrome described as a form of hypermetropia with not more than +2.00 diopters.", + "output": "Mild hyperopia (Hyperopia)" + }, + { + "input": "Definition: Organic Chemical described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.", + "output": "BEST'S CARMINE (Organic Chemical)" + }, + { + "input": "Definition: Enzyme described as mitogen-activated protein kinase 10 (464 aa, ~53 kDa) is encoded by the human MAPK10 gene. This protein is involved in serine/threonine phosphorylation, cytokine-dependent and stress-activated signaling and transcriptional regulation.", + "output": "c-Jun Kinase 3 (Mitogen-Activated Protein Kinases)" + }, + { + "input": "Definition: something described as human LLGL1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 19 kb in length. This allele, which encodes lethal(2) giant larvae protein homolog 1 protein, plays a role in the regulation of mitotic spindle orientation, cell proliferation, neuroepithelial cell differentiation, tumor suppression and cytoskeletal maintenance. Aberrant expression of the gene is associated with the progression of both colorectal cancers and melanoma.", + "output": "LLGL1 wt Allele (LLGL1 gene)" + }, + { + "input": "Definition: Phosphatidylinositide 3-Kinase Inhibitor described as an orally bioavailable inhibitor of phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor DS-7423 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97254\" active clinical trials using this agent.", + "output": "PI3K/mTOR Kinase Inhibitor DS-7423 (Phosphatidylinositide 3-Kinase Inhibitor)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 protein (336 aa, ~38 kDa) is encoded by the human ST6GALNAC5 gene. This protein plays a role in regulation of extracellular matrix biosynthesis.", + "output": "GalNac Alpha-2,6-Sialyltransferase V (glycosyltransferase)" + }, + { + "input": "Definition: Finding described as a finding of escape to nostril with or without emission during swallowing.", + "output": "Escape to nostril with/without emission (Impairment of Soft Palate Elevation)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Level 3b Small for Gestational Age is defined by three criteria: first, the weight is below the 10th percentile for gestational age; second, the infant is weighed within the first 48 hours of life, and the weight is assessed on any scale by measuring the difference between an adult holding the infant and the adult being weighed alone; third, gestational age is assessed by one of following three methods: a) Uncertain LMP with fundal height; b) Uncertain LMP with newborn physical assessment; or c) Uncertain LMP with birthweight.", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 3b Small for Gestational Age (GAIA Small for Gestational Age Level of Diagnostic Certainty)" + }, + { + "input": "Definition: Abnormal response to glucagon stimulation test described as an abnormally high increase in insulin levels following a glucagon stimulation test.", + "output": "Excessive insulin response to glucagon test (Abnormal response to glucagon stimulation test)" + }, + { + "input": "Definition: Organ or Tissue Function described as excitatory postsynaptic potentials at the NEUROMUSCULAR JUNCTION.", + "output": "End Plate Potential (Organ or Tissue Function)" + }, + { + "input": "Definition: Pediatric formula described as liquid formula intended for enteral and/or oral method of delivery, formulated to meet the nutritional needs of children. Designed with elemental energy (kcal/kJ) sources to improve GI tolerance.", + "output": "Pediatric elemental formula (Pediatric formula)" + }, + { + "input": "Definition: something described as study of cell morphology, structure, physiology, etc as it passes into a pathologic state or through the pathologic process.", + "output": "Pathology, Cellular (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Abnormal oral cavity morphology described as any abnormality of the tongue.", + "output": "Glossal abnormality (oral cavity symptoms)" + }, + { + "input": "Definition: Unit of area described as a unit of area equal to 4046.87261 square meters. The unit is based on the USA survey foot of 1200/3937 meters.", + "output": "Acre (Quantitative Concept)" + }, + { + "input": "Definition: Dysostosis of bone of skull described as a hand or foot with more than five digits that has a recognizable A/P axis of symmetry. The axis can lie within a normally formed or partially duplicated digit resembling a middle finger, index finger, thumb, toe, or hallux. Alternatively, the axis can be in an interdigital space with a flanking pair of digits that resemble a middle finger, index finger, thumb, toe or hallux. The most lateral digits on each side of the hand typically resemble fifth fingers/toes.", + "output": "Mirror-Image Polydactyly (Polysyndactyly)" + }, + { + "input": "Definition: Pharmacologic Substance described as an essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67080\" active clinical trials using this agent.", + "output": "(5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as using a steam room that accommodates one or more clients to induce perspiration. Service is billed in 15-minute increments.", + "output": "Steam room each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Amniotic Fluid described as a clinical finding in which there is the accumulation of excessive fluid in the interstitial spaces, and appears as swelling on visual inspection.", + "output": "Oedema, NOS (Edema, not elsewhere classified in ICD10CM)" + }, + { + "input": "Definition: something described as a cationic cholesterol derivative mixed with dimethylaminoethane-carbamoyl and sonicated to form small unilamellar vesicles that can complex with DNA, DNA/protein complexes and other drug complexes and mediates the delivery into the cytosol from the endosome compartment.", + "output": "dimethylaminoethane-carbamoyl-cholesterol liposomes (Pharmacologic Substance)" + }, + { + "input": "Definition: mannosyl-oligosaccharide mannosidase activity described as catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide.", + "output": "1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity (mannosyl-oligosaccharide mannosidase activity)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's assessment of whether the decision shows or showed what is important to them.", + "output": "Decision Shows What is Important (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the amino acid residue at position 172 in the isocitrate dehydrogenase [NADP], mitochondrial protein where arginine has been replaced by another amino acid. Mutations at this position are found in patients with acute myeloid leukemia following myelodysplastic syndromes and is associated with shorter overall survival.", + "output": "Isocitrate Dehydrogenase [NADP+], Mitochondrial R172X (IDH2 Protein Variant)" + }, + { + "input": "Definition: Eukaryote described as class of the phylum Mollusca that includes the snails, whelks, slugs, and limpets.", + "output": "Class gastropoda (Eukaryote)" + }, + { + "input": "Definition: Hemoglobin variant test described as the determination of the amount of hemoglobin A present in a sample.", + "output": "Haemoglobin A measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2.", + "output": "dimethylmalonate decarboxylase activity (carboxy-lyase activity)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the degradation of the extracellular matrix. It also plays a role in the suppression of endothelial cell proliferation.", + "output": "TIMP2 gene (Gene or Genome)" + }, + { + "input": "Definition: something described as terminology used in support of the American College of Cardiology (ACC)/American Heart Association's (AHA) efforts to collect key elements pertaining to clinical data obtained from electronic health records.", + "output": "ACC-AHA EHR Terminology (Terminology Subset)" + }, + { + "input": "Definition: Hereditary Diseases described as a rare genetic multiple congenital anomalies/dysmorphic syndrome with characteristics of severe white matter hypoplasia, corpus callosum agenesis or extreme hypoplasia, severe intellectual disability, failure to thrive and minor midline facial dysmorphism (including hypertelorism, broad nasal root, micrognathia). There have been no further descriptions in the literature since 1993.", + "output": "White matter hypoplasia, corpus callosum agenesia, and mental retardation (Hereditary Diseases)" + }, + { + "input": "Definition: something described as catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A.", + "output": "3-oxo-lignoceronyl-CoA synthase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: something described as a Breast lesion documentation device is a device for recording and documenting palpable breast lesions detected during a clinical breast exam.", + "output": "SYSTEM, DOCUMENTATION, BREAST LESION (Medical Device)" + }, + { + "input": "Definition: Disorder of anterior chamber of eye described as an accumulation of pus in the anterior chamber of the eye.", + "output": "hypopyon (Inflammation of specific body systems)" + }, + { + "input": "Definition: Renal Calculi, CTCAE described as symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated", + "output": "Grade 2 Renal calculi (Renal Calculi, CTCAE)" + }, + { + "input": "Definition: something described as a measurement of the birch pollen IgA in a biological specimen.", + "output": "Birch Pollen IgA (Laboratory Procedure)" + }, + { + "input": "Definition: Medical Device described as (a) A telethermographic system for adjunctive diagnostic screening for detection of breast cancer or other uses is an electrically powered device with a detector that is intended to measure, without touching the patient's skin, the self-emanating infrared radiation that reveals the temperature variations of the surface of the body. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories. (b) A telethermographic system for use as the sole diagnostic screening tool for detection of breast cancer or other uses is an electrically powered device with a detector that is intended to measure, without touching the patient's skin, the self-emanating infrared radiation that reveals the temperature variations of the surface of the body. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories.", + "output": "SYSTEM, TELETHERMOGRAPHIC (Medical Device)" + }, + { + "input": "Definition: White Blood Cell Count procedure described as a measurement of the immature basophils in a biological specimen.", + "output": "immature basophil count (White Blood Cell Count procedure)" + }, + { + "input": "Definition: something described as a disorder characterized by failure of the left ventricle to produce adequate output.", + "output": "Left Ventricular Systolic Dysfunction, CTCAE 5 (Cardiac Disorders, CTCAE)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide.", + "output": "aliphatic (R)-hydroxynitrile lyase activity (Molecular Function)" + }, + { + "input": "Definition: regulation of protein dephosphorylation described as any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.", + "output": "upregulation of protein amino acid dephosphorylation (regulation of protein dephosphorylation)" + }, + { + "input": "Definition: Dental dosage form described as liquid preparation to be applied to dentures to form a lacquer by evaporation of the volatile solvent.", + "output": "Denture Lacquer Dosage Form (Dental dosage form)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify species of Bartonella, a genus of rod-shaped bacteria of the family Bartonellaceae, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target bacteria. Some species of these bacteria may cause human infections, including benign lymphoreticulosis (cat-scratch disease); they are also associated with endocarditis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bartonella Species, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bartonella Species)" + }, + { + "input": "Definition: Intellectual Product described as inventory of Depressive Symptomatology Self-Report Version (IDS-SR) Please circle the one response to each item that best describes you for the past seven days: Constipation/diarrhea.", + "output": "IDS-SR - Constipation or Diarrhea (IDS-SR Questionnaire Question)" + }, + { + "input": "Definition: Plant described as a plant genus of the family ASCLEPIADACEAE. Members contain pregnane glycosides (marsdekoiside & marstomentosides, maryal) and hainaneosides (SAPONINS).", + "output": "Marsdenia R.Br. (Family Asclepiadaceae - milkweed)" + }, + { + "input": "Definition: Physiologic Function described as the process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit.", + "output": "fruit septum development (post-embryonic development)" + }, + { + "input": "Definition: Gastrointestinal Diseases described as impaired absorption of nutrients in the gastrointestinal tract.", + "output": "Malabsorption syndromes (Intestinal Diseases)" + }, + { + "input": "Definition: something described as absence of urine, clinically classified as below 50ml/day.", + "output": "Failure of urine formation (FUNCTIONS AND ABNORMAL FUNCTIONS OF THE LOWER URINARY TRACT)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the study of mechanisms and processes by which mechanical forces elicit molecular response and regulate cell form and function.", + "output": "Mechanobiology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the lactate dehydrogenase isoenzyme 5 to total lactate dehydrogenase in a biological specimen.", + "output": "LDH Isoenzyme 5/LDH (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Idea or Concept described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to nonclinical pregnancy results.", + "output": "Nonclinical Pregnancy Results (Idea or Concept)" + }, + { + "input": "Definition: Transferase described as an isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in muscle. Mutation of the gene coding this enzyme is the cause of McArdle disease (GLYCOGEN STORAGE DISEASE TYPE V).", + "output": "Phosphorylase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as small, red dots in the superficial retinal layers (it is difficult to distinguish between small hemorrhages and microaneurysms). []", + "output": "Macular microaneurysm/hemorrhage (Retinal Microaneurysm)" + }, + { + "input": "Definition: Medical Devices described as a device used to stretch or enlarge an opening.", + "output": "dilator (Surgical Instruments)" + }, + { + "input": "Definition: Musculoskeletal and connective tissue disorders described as fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma.", + "output": "Path fx unspecified site (Pathologic Function)" + }, + { + "input": "Definition: Cell Function described as the change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "output": "myeloid dendritic cell activation involved in immune response (myeloid cell activation involved in immune response)" + }, + { + "input": "Definition: Antepartum fetal status described as a non-invasive test usually done during the third trimester to check for fetal well being. It is performed using an external fetal heart rate monitor to assess the fetal heart rate response to fetal movements.", + "output": "nonstress tests (diagnostic procedure)" + }, + { + "input": "Definition: something described as an ultraviolet activator for polymerization is a device that produces ultraviolet radiation intended to polymerize (set) resinous dental pit and fissure sealants or restorative materials by transmission of light through a rod.", + "output": "ACTIVATOR, ULTRAVIOLET, FOR POLYMERIZATION (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a major histocompatibility complex class I-like protein that contains an IMMUNOGLOBULIN C1-SET DOMAIN. It plays a unique role in the presentation of lipid ANTIGENS to NATURAL KILLER T-CELLS.", + "output": "CD1d Antigen (Immunologic Factor)" + }, + { + "input": "Definition: Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process.", + "output": "down regulation of toluene catabolism (negative regulation of toluene metabolic process)" + }, + { + "input": "Definition: Neoplasm, uncertain whether benign or malignant described as a sex cord-stromal tumor of the testis or the ovary. It is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course.", + "output": "Pick tubular adenoma (Benign neoplasm of testis)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine.", + "output": "lysine-pyruvate 6-transaminase activity (Molecular Function)" + }, + { + "input": "Definition: Abnormal erythrocyte enzyme level described as decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.", + "output": "Reduced red cell adenosine deaminase level (Finding)" + }, + { + "input": "Definition: something described as one of ten visual areas in the rat ( Swanson-2004 ). See visual cortex (rodent).", + "output": "posterolateral visual area (Body Location or Region)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as using speech and language rehabilitation therapy, including drill repetition and breathing exercises, with a patient to improve and/or maintain his or her speech function for as long as possible.", + "output": "dysarthia speech&lang rehab. (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Quantitative Concept described as days times micrograms per milliliter, divided by kilograms.", + "output": "d.ng/mL/g (Measurement Unit Description)" + }, + { + "input": "Definition: Malignant Neoplasms described as cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment, or it may become resistant during treatment.", + "output": "refractory cancer (Malignant Neoplasms)" + }, + { + "input": "Definition: Intellectual Product described as auditory Verbal Learning Test Version A - List A, Recall 4, Word 15.", + "output": "AVL01-List A Recall 4 Word 15 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: something described as a question about whether an individual must move their bowels frequently to avoid accidents.", + "output": "I must move my bowels frequently to avoid accidents (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Temporal Concept described as the date and time of body weight assessment data collection.", + "output": "BWDTC (Temporal Concept)" + }, + { + "input": "Definition: Lymph Node by Anatomic Site described as a lymph node located adjacent to the lumbar region of the spine.", + "output": "Latero-aortic lymph node (Parietal lymph node group of abdomen proper)" + }, + { + "input": "Definition: something described as a measurement of the Human Parainfluenza antigen in a biological specimen.", + "output": "Human Parainfluenza Antigen (Microbiology procedure)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether a person would prefer to hear details only in certain circumstances.", + "output": "I want to hear details only in certain situations, such as when tests are abnormal or when treatment decisions need to be made (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 (NCCN-FACT FBRSI-24 Version 2) I have difficulty expressing my thoughts.", + "output": "FAC03008 (Intellectual Product)" + }, + { + "input": "Definition: Malignant Squamous Cell described as a malignant squamous cell that does not produce keratin.", + "output": "Non-Keratinizing Malignant Squamous Cell (Malignant Squamous Cell)" + }, + { + "input": "Definition: something described as catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine.", + "output": "trans-aconitate 2-methyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Family described as individuals related through family or marriage or other relationships recognized by the culture as extended family, such as aunts, uncles, nephews and nieces.", + "output": "Families, Extended (family structure)" + }, + { + "input": "Definition: Hydrolase Gene described as this gene is involved in DNA mismatch repair.", + "output": "methyl-CpG binding domain protein 4 (Hydrolase Gene)" + }, + { + "input": "Definition: Carcinomatosis described as a serious problem that may occur in cancer in which cancer cells spread from the original (primary) tumor to the meninges (thin layers of tissue that cover and protect the brain and spinal cord). It can happen in many types of cancer, but is the most common in melanoma, breast, lung, and gastrointestinal cancer. The cancer may cause the meninges to be inflamed.", + "output": "Carcinomatosis of the Meninges (Carcinomatosis)" + }, + { + "input": "Definition: Ascomycota described as the largest family of lichen-forming fungi.", + "output": "Alectoriaceae (Lichen - organism)" + }, + { + "input": "Definition: Trophoblastic Neoplasms described as an aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.", + "output": "Choriocarcinoma, no ICD-O subtype (Germ cell neoplasms site unspecified NEC)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an insertion of the amino acid sequence glycine-threonine between the aspartic acid at position 770 and the asparagine at position 771 of the epidermal growth factor receptor protein.", + "output": "EGFR Asp770 Asn771insGlyThr (EGFR Protein Variant)" + }, + { + "input": "Definition: Inflammation of specific body organs described as sudden inflammation of the tracheobronchial tree, which comprises the trachea, or windpipe, and the bronchi; typically associated with a viral upper respiratory tract infection, such as the common cold, and is usually mild; in patients with chronic lung or heart disease, acute bronchitis is more severe, and can become chronic and progress to pneumonia.", + "output": "acute; tracheobronchitis (Tracheobronchitis)" + }, + { + "input": "Definition: WPAI:SHP v2.0 Questionnaire Question described as work Productivity and Activity Impairment Questionnaire-Specific Health Problem v2.0 (WPAI:SHP) Presenteeism score.", + "output": "WPAI0108 (WPAI:SHP v2.0 Questionnaire Question)" + }, + { + "input": "Definition: Mood finding described as appropriate adjustment of prevailing emotional tone in response to circumstances", + "output": "Mood Equilibrium (Personal health status)" + }, + { + "input": "Definition: Immunologic Responses and Immune States described as a condition in which the skin or eyes become very sensitive to sunlight or other forms of light. It can be caused by taking certain drugs, or rubbing certain essential oils (scented liquid taken from plants) or other topical agents into the skin. Phototoxicity causes sunburn, blisters, and other skin problems.", + "output": "PHOTOTOX (Photosensitivity of skin)" + }, + { + "input": "Definition: Normal Statistical Distribution described as a normal distribution which models two variables of interest. The parameters of the bivariate normal distribution include the mean and variance of each individual variable and the correlations between variables.", + "output": "Bi-variate Normal Distribution (Quantitative Concept)" + }, + { + "input": "Definition: something described as a sensation of discomfort or distress that is distinct and intensely focused.", + "output": "Sharp pain (Sign or Symptom)" + }, + { + "input": "Definition: Functional Concept described as entamoeba histolytica, an extracellular protozoan parasite, is a human pathogen that invades the intestinal epithelium. Infection occurs upon ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection, like amoebic liver abscess, by evading the immune response.", + "output": "Entamoeba histolytica Infection Pathway (Infectious Disease Pathway)" + }, + { + "input": "Definition: Wild flowers described as a plant family of the order THEALES, subclass Dilleniidae, class Magnoliopsida, best known for CAMELLIA SINENSIS, which is the source of Oriental TEA.", + "output": "FAMILY THEACEAE (Ericales)" + }, + { + "input": "Definition: Genetic Function described as any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.", + "output": "regulation of transcription involved in G1/S transition of mitotic cell cycle (mitotic cell cycle process)" + }, + { + "input": "Definition: Neoplastic Process described as an adenoma of the anterior lobe of the pituitary gland that produces luteinizing hormone (LH).", + "output": "LH-producing Adenoma (Neoplastic Process)" + }, + { + "input": "Definition: Biologically Active Substance described as paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.", + "output": "paxillin (Phosphoproteins)" + }, + { + "input": "Definition: Finding described as levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer", + "output": "Grade 1 Cardiac troponin T increased (Finding)" + }, + { + "input": "Definition: CDISC Clinical Classification Terminology described as ATLAS test name.", + "output": "ATLAS1TN (Intellectual Product)" + }, + { + "input": "Definition: biology described as systematic study of the biological basis of all aspects of social behavior. Used for both human and animal populations.", + "output": "Sociobiology (Occupation or Discipline)" + }, + { + "input": "Definition: Genetic Function described as conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.", + "output": "generation of catalytic spliceosome for second transesterification step (Genetic Function)" + }, + { + "input": "Definition: cellular response to lipid described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.", + "output": "cellular response to fatty acid (cellular response to oxygen-containing compound)" + }, + { + "input": "Definition: Cell Cycle Proteins described as sister chromatid cohesion protein PDS5 homolog B (1447 aa, ~165 kDa) is encoded by the human PDS5B gene. This protein plays a role in the regulation of both mitosis and cell proliferation.", + "output": "Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS3 (Biologically Active Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cell surface receptors that are specific for INTERLEUKIN-6. They are present on T-LYMPHOCYTES, mitogen-activated B-LYMPHOCYTES, and peripheral MONOCYTES. The receptors are heterodimers of the INTERLEUKIN-6 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130.", + "output": "il-6 receptor (Receptor)" + }, + { + "input": "Definition: something described as infestation with mites of the genus Trombicula, whose larvae carry the rickettsial agent of scrub typhus.", + "output": "itch; harvest (Mite Infestations)" + }, + { + "input": "Definition: Clinical or Research Facility described as the Immunoelectron Microscopy Shared Resource provides support to Cancer Center investigators in ultrastructural analysis by conventional electron microscopy in conjunction with immunolocalization techniques, including ultra-cryomicrotomy, and internal antigens immuno-labeling.", + "output": "Immunoelectron Microscopy Shared Facility (Clinical or Research Facility)" + }, + { + "input": "Definition: METABOLISM: GENERAL TERMS described as the conversion of an exogenous substance by a biological system resulting in the production on an active metabolite.", + "output": "metabolic activation (Metabolic Biotransformation)" + }, + { + "input": "Definition: Manufactured Object described as a provider organization, or distinct part of the organization, which renders an interdisciplinary program providing palliative care, chiefly medical relief of pain and supporting services, which addresses the emotional, social, financial, and legal needs of terminally ill patients and their families where an institutional care environment is required for the patient.", + "output": "Hospice, Inpatient (Health Care Related Organization)" + }, + { + "input": "Definition: Nausea Scale described as a subjective score of 0 on a scale that ranges from 0: None to 10: The worst you can think of.", + "output": "Nausea Score 0 (Nausea Scale)" + }, + { + "input": "Definition: something described as a question about whether an individual feels or felt that people act as if they think the individual is not smart.", + "output": "People Act as if They Think You are Not Smart (Intellectual Product)" + }, + { + "input": "Definition: Health Care Activity described as reassesses tissue perfusion to determine changes from baseline throughout the perioperative phase of care.", + "output": "Evaluates tissue perfusion (Health Care Activity)" + }, + { + "input": "Definition: Medical Device described as a gastroenterology-urology biopsy instrument is a device used to remove, by cutting or aspiration, a specimen of tissue for microscopic examination. This generic type of device includes the biopsy punch, gastrointestinal mechanical biopsy instrument, suction biopsy instrument, gastro-urology biopsy needle and needle set, and nonelectric biopsy forceps. This section does not apply to biopsy instruments that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.", + "output": "INSTRUMENT, BIOPSY, SUCTION (Medical Device)" + }, + { + "input": "Definition: Cabinets, Filing described as filing cabinets designed to store cards upright and either perpendicular or parallel to the front of the cabinet (lateral and vertical filing, respectively). These cabinets typically consist of a metallic or wooden stand-alone structure, including one or more drawers that can accommodate cards of one or more size (e.g., 6 x 9 inch, 5 x 8 inch); they may include dividers to store several rows of cards in each drawer. Many card filing cabinets include locking systems and/or mechanisms that allow only one drawer to open at a time to avoid tipping; they are available in many different configurations and sizes. These cabinets are used to store many different types of information in healthcare facilities, including medical records, laboratory results, device status, and library and financial information and/or inventories.", + "output": "Medical Card Filing Cabinets (Cabinets, Filing)" + }, + { + "input": "Definition: Enzymes described as an enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloacetate from phosphoenolpyruvate and carbon dioxide. This fixation of carbon dioxide in several bacteria and some plants is the first step in the biosynthesis of glucose. EC 4.1.1.31.", + "output": "Orthophosphate:oxaloacetate carboxy-lyase (Enzyme)" + }, + { + "input": "Definition: Blood and lymphatic system disorders described as a non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003 Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3466\" active clinical trials using this agent.", + "output": "LYMPHOMA T CELL (Lymphoma, Non-Hodgkin)" + }, + { + "input": "Definition: something described as an indication of the type of unit of measure being used to express a height.", + "output": "Unit of Height (Unit by Category)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose.", + "output": "exo-beta-D-galactofuranosidase activity (Molecular Function)" + }, + { + "input": "Definition: Immunologic Tests described as a relative measurement (ratio or percentage) of beta-2-fraction proteins to total proteins in a biological specimen.", + "output": "GLOBB2PT (Immunologic Tests)" + }, + { + "input": "Definition: metabolism by organism of protein in other organism involved in symbiotic interaction described as the chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "metabolism by symbiont of host protein (metabolism by organism of protein in other organism involved in symbiotic interaction)" + }, + { + "input": "Definition: Nucleotide Biosynthesis described as the chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.", + "output": "cyclic nucleotide anabolism (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 3 Months Version - These are more questions about your cough and shortness of breath these days: I get exhausted easily.", + "output": "SGRQ0124 (Intellectual Product)" + }, + { + "input": "Definition: Reticular Formation described as a group of cells located dorsal to the motor nucleus of the trigeminal nerve in the human ( Paxinos-2012 ), the macaque ( Paxinos-2009a ), the rat ( Swanson-2004 ), and the mouse ( Paxinos-2001 ). Functionally it belongs to the reticular formation (functional) of the subcortical motor system ( Swanson-2004 ).", + "output": "supratrigeminal nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a set of observational data ordered in time, typically with observations made at regular intervals.", + "output": "time series (statistical analysis)" + }, + { + "input": "Definition: something described as the protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, without mention of obstruction or necrosis of the herniated contents.", + "output": "Hernia of other specified sites without mention of obstruction or gangrene (Other hernia of abdominal cavity without mention of obstruction or gangrene)" + }, + { + "input": "Definition: Equipment and Supplies described as apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.", + "output": "Electrical Equipment and Supplies (Equipment and Supplies)" + }, + { + "input": "Definition: Clippers, Nail, Toe described as clippers designed for use by individuals with physical limitations (i.e., disabilities) for cutting their own toenails; these devices use a mechanism that performs a two-blade clipping action to cut straight across the nail, preventing ingrowth. These clippers are typically strong, manual instruments with a far-reaching mechanism (e.g., pistol-grip action) and two small articulated metal pieces with straight cutting edges, used for personal hygiene and grooming.", + "output": "Toe Nail Clippers, Disabled Person (Manufactured Object)" + }, + { + "input": "Definition: Anesthetics, Intravenous described as a cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation.", + "output": "Product containing ketamine (Preparation K)" + }, + { + "input": "Definition: Intellectual Product described as a question about the physical support that a person requires.", + "output": "Extremity Supports (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Colorectal Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v8 described as colorectal neuroendocrine tumor with regional lymph node metastasis.", + "output": "Colorectal Neuroendocrine Tumor pN1 TNM Finding v8 (Colorectal Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen described as catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol.", + "output": "2,4,5-trichlorophenoxyacetic acid oxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.", + "output": "vesicle organisation (organelle organization)" + }, + { + "input": "Definition: Anticoagulants described as a form of the human glycoprotein antithrombin-III (AT-III), which is produced recombinantly or isolated from human plasma, with anticoagulant activity. Upon administration, antithrombin-III binds to and blocks thrombin activity, and prevents thrombus formation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C104683\" active clinical trials using this agent.", + "output": "ANTITHROMBIN III HUMAN (Pharmacologic Substance)" + }, + { + "input": "Definition: Body Substance described as a concretion in the body that is composed of more than one substance.", + "output": "Mixed stones (Mixed calculus)" + }, + { + "input": "Definition: Congenital anomaly of vertebral region of back described as a rare neurological disease with characteristics of congenital narrowing of the bony anatomy of the cervical spinal canal. This disorder predisposes the individual to symptomatic neural compression with manifestations including cramps, paresthesia, pain, muscle hypertonia and weakness, myelopathy and sphincter disturbances.", + "output": "Congenital stenosis of cervical spinal canal (congenital stenosis)" + }, + { + "input": "Definition: inhibition and disinhibition described as unrestrained behavior, often at odds with social norms.", + "output": "Disinhibition (Mental and Behavioral Signs and Symptoms)" + }, + { + "input": "Definition: something described as to divide by cutting transversely the part of the brain that connects the cerebral hemispheres with the spinal cord.", + "output": "brain stem transection (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a white blood cell that lacks cytoplasmic granules with an affinity for specific biological stains; typically, a lymphocyte, monocyte, or plasma cell.", + "output": "mononuclear leukocytes (Leukocytes)" + }, + { + "input": "Definition: Special Education described as speech development that is below normal for a specific age level.", + "output": "Retarded Speech Development (Special Education)" + }, + { + "input": "Definition: Other Personal Medical History described as a hypersensitivity reaction triggered by exposure to a previously encountered foreign substance to which the individual has formed antibodies.", + "output": "Allergic reaction (allergic or immunologic symptoms)" + }, + { + "input": "Definition: Sign or Symptom described as vomiting that ejects the gastric contents with great force.", + "output": "VOMIT PROJECTILE (Nausea and vomiting)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the beta-emitting radionuclide yttrium 90 (Y-90), with radioimmunotherapeutic activity. After pre-treating and targeting tumor cells with a bi-specific monoclonal antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of the administered yttrium Y 90-DOTA-di-HSG peptide IMP-288 binds to the anti-HSG sequence on the BiMoAB. In turn, Y-90 delivers a cytotoxic dose of beta radiation to tumor cells expressing the specific TAA.", + "output": "90Y-IMP288 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Salivary Gland Infection, CTCAE described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Salivary gland infection (Salivary Gland Infection, CTCAE)" + }, + { + "input": "Definition: glycerolipid biosynthetic process described as the chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.", + "output": "acylglycerol anabolism (neutral lipid biosynthetic process)" + }, + { + "input": "Definition: Meters, analysers and monitors described as oximeters designed primarily for determining the relative amount of oxygenated and deoxygenated hemoglobin (O2Hb and HHb, respectively) by measuring light absorbence changes resulting from arterial blood flow pulsations and displaying the results as percent saturation of hemoglobin in arterial blood (SpO2). These oximeters include red and infrared light sources (typically LEDs of 660 and 940 nm), photodetectors, and probes that transmit light through a pulsating arterial bed, such as the finger tip, earlobe, or toe. Pulse oximeters are used in operating rooms, intensive care units, recovery rooms, and sometimes in emergency vehicles or for patient respiratory care at home.", + "output": "pulse oximeters (Oxygen analyzer, device)" + }, + { + "input": "Definition: FACT-LEU Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family.", + "output": "FAC017-Trouble Meeting Needs of Family (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as prostate cancer with distant metastasis.", + "output": "Prostate Cancer cM1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as an innocent murmur with a medium or high pitched, blowing character heard at the left middle sternal border that can also be heard at the same volume across the precordium and back that does not disappear with maneuvers but is only heard in infants less than 6 mo of age.", + "output": "Physiologic pulmonary artery stenosis (Finding)" + }, + { + "input": "Definition: something described as therapeutic and adverse effects of prescribed medication", + "output": "Response to medication (Drug therapy observable)" + }, + { + "input": "Definition: Fetal Diseases described as fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (PMID:16100637).", + "output": "Fetal choroid plexus cysts (Malformation of central nervous system of fetus)" + }, + { + "input": "Definition: Finding described as extent of understanding conveyed about depression and interrelationships among causes, effects, and treatments", + "output": "Knowledge: Depression Management (Finding)" + }, + { + "input": "Definition: WPAI:SHP v2.0 Questionnaire Question described as work Productivity and Activity Impairment Questionnaire-Specific Health Problem v2.0 (WPAI:SHP) During the past seven days, how many hours did you actually work?", + "output": "WPAI01-Hours Actually Worked (WPAI:SHP v2.0 Questionnaire Question)" + }, + { + "input": "Definition: Qualitative Concept described as descriptive of a condition that may or is likely to become cancerous.", + "output": "premalignant (Disease Morphology Qualifier)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual uses or used a feeding tube.", + "output": "Have you used a feeding tube (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Administration of analgesic described as relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).", + "output": "PCA (Pain management)" + }, + { + "input": "Definition: Apocynaceae described as a plant genus of the family APOCYNACEAE. Members contain voacangine and other INDOLES.", + "output": "Voacangas (Plant)" + }, + { + "input": "Definition: Pharmacologic Substance described as a cancer vaccine consisting of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the gene for the CD4 epitope-rich C-terminal domain of the Epstein Barr Virus (EBV) antigen EBNA1 and fused to the full-length of the EBV-associated antigen latent membrane protein 2 (LMP2), with potential immunostimulatory and antineoplastic activities. Upon administration, MVA EBNA1/LMP2 vaccine may elicit a cytotoxic T-cell immune response against cancer cells expressing EBNA1 and LMP2. Multi-antigen vaccine therapy may be more efficacious than single-antigen therapy vaccine therapy. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation.", + "output": "MVA-EBNA1/LMP2 vaccine (Vaccinia Vaccine)" + }, + { + "input": "Definition: Localization-related idiopathic epilepsy described as a neurological disorder of childhood characterized by partial seizures consisting of twitching, numbness, or tingling of the face or tongue that often progress to secondary generalized seizures.", + "output": "BCECTS (Cognitive and attention disorders and disturbances NEC)" + }, + { + "input": "Definition: Carts, Storage/Transport described as carts designed for organized storage, transport, and easy access of mechanical set-ups used in orthopedic traction treatments. These carts usually consist of sturdy structures to facilitate handling of heavy cast iron weights, long traction bars, and other accessories typically used in combination with traction tables and/or stands. Some carts may also include an enclosure appropriate for devices and other supplies used by orthopedic technicians. Orthopedic traction carts are used in orthopedic departments to transport heavy devices from and to traction tables and/or stands.", + "output": "Carts, Storage/Transport, Orthopedic Traction Attachments (Carts, Storage/Transport)" + }, + { + "input": "Definition: Receptor described as an isoform produced by alternative splicing.", + "output": "Thyroid Hormone Receptor alpha 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as technique based on muscle relaxation during self-hypnotic exercises. It is used in conjunction with psychotherapy.", + "output": "autogenic training (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as a dataset used to represent non-standard variables and their association to parent records in the Substance Use domain.", + "output": "Substance Use Supplemental Qualifiers Dataset (Intellectual Product)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Dialister pneumosintes.", + "output": "Bacterium pneumosintes (Bacterium)" + }, + { + "input": "Definition: regulation of lipid transporter activity described as any process that modulates the rate, frequency, or extent of cholesterol transporter activity.", + "output": "regulation of cholesterol transporter activity (Physiologic Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the ability of an individual to do chores such as vacuuming and yardwork.", + "output": "Able to do Household Chores (Intellectual Product)" + }, + { + "input": "Definition: Systemic Chemotherapy Course Label described as the third chemotherapy course planned.", + "output": "Chemotherapy Course 3 (Systemic Chemotherapy Course Label)" + }, + { + "input": "Definition: DISORDERS OF PHOSPHORUS AND CALCIUM METABOLISM described as an abnormally increased phosphate concentration in the blood.", + "output": "hyperphosphatemia (Abnormal blood phosphate concentration)" + }, + { + "input": "Definition: Intellectual Product described as a web-based knowledge environment that includes freely available data derived from small molecules and small-molecule screens and resources for studying the data so that biological and medical insights can be gained.", + "output": "ChemBank (Information Resources)" + }, + { + "input": "Definition: something described as a finding indicating that the neoplastic cells in a breast cancer tissue sample test positive for estrogen, progesterone, and HER2 receptors.", + "output": "Triple Positive (Positive Laboratory Test Result)" + }, + { + "input": "Definition: Clinical Enzyme Tests described as the determination of the amount of angiotensin converting enzyme present in a sample.", + "output": "Angiotensin I - converting enzyme (Clinical Enzyme Tests)" + }, + { + "input": "Definition: ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) Which one best describes how the subject usually selects items.", + "output": "ADL01-How Usually Selects Items (Intellectual Product)" + }, + { + "input": "Definition: Chromosomes described as a specific pair of GROUP D CHROMOSOMES of the human chromosome classification.", + "output": "13 chromosomes (Chromosomes, Human, 13-15)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). After binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting protein synthesis through ADP-ribosylation of elongation factor.", + "output": "transferrin-CRM107 (Immunotoxins)" + }, + { + "input": "Definition: Cell Component described as a ciliary basal body that is part of a kinocilium.", + "output": "ciliary basal body of kinocilium (Cell Component)" + }, + { + "input": "Definition: something described as a question about whether an individual feels that their medical care improves when they see the same doctor that they have seen before.", + "output": "My Medical Care Improves When I See the Same Doctor that I Have Seen Before (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual pays someone for full-time help.", + "output": "Pay For Full-time Help (Finding)" + }, + { + "input": "Definition: something described as days times picograms per milliliter (area under the curve), divided by kilograms per meter squared (body mass index).", + "output": "Day Times Picogram per Milliliter per Kilogram per Meter Squared (Quantitative Concept)" + }, + { + "input": "Definition: Regulatory Protein described as putative macrophage-stimulating protein MSTP9 (715 aa, ~80 kDa) is encoded by the human MST1L gene. This protein is a non-functional member of the peptidase S1 family.", + "output": "Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) Pseudogene 9 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Vitamin disease described as a nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur.", + "output": "Deficiency of folic acid (Vitamin B Deficiency)" + }, + { + "input": "Definition: Intellectual Product described as emotion Recognition - Number of surprise stimuli responded to as disgust.", + "output": "EMO1-Surprise Responded as Disgust (Intellectual Product)" + }, + { + "input": "Definition: Hematologic Tests described as measurement of hemoglobin concentration in blood.", + "output": "Hemoglobinometries (Hematologic Tests)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as all methods of preventing cancer including limit of exposure to carcinogens and infectious agents, diet, education, etc", + "output": "Cancer Prevention (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Nitrogen-Fixing Bacteria described as a family of aerobic gram-negative rods that are nitrogen fixers. They are highly viscous, and appear as a semitransparent slime in giant colonies.", + "output": "Beijerinckia group (Rhizobiales)" + }, + { + "input": "Definition: something described as a fusion protein encoded by the MYB/NFIB fusion gene. This protein is comprised of most of transcriptional activator Myb protein fused to the amino acids comprising the extreme C-terminus of nuclear factor 1 B-type protein.", + "output": "MYB-NF1-B Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene.", + "output": "gamma-hexachlorocyclohexane dehydrochlorinase activity (carbon-halide lyase activity)" + }, + { + "input": "Definition: Enterobacter described as a species of facultatively anaerobic, Gram negative, rod shaped bacteria in the phylum Proteobacteria. This species is obligately intracellular, acidophilic, indole negative and utilizes lactulose and putrescine as carbon sources. C. sakazakii is pathogenic, being the causative agent of meningitis and necrotizing enterocolitis, and is associated with tainted powdered infant formulas.", + "output": "Cronobacter sakazakii (Cronobacter)" + }, + { + "input": "Definition: Organism Attribute described as the genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.", + "output": "Haplotype (Miscellaneous Molecular Biology Terms)" + }, + { + "input": "Definition: something described as reported values within the typical or expected range.", + "output": "STNRC (Intellectual Product)" + }, + { + "input": "Definition: Enzyme described as a ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.", + "output": "Peptidase 7, Ubiquitin-Specific (ubiquitin C-terminal hydrolase)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in chromatin remodeling and regulation of transcription.", + "output": "SMARCB1 (Gene or Genome)" + }, + { + "input": "Definition: negative regulation of cardioblast cell fate specification described as any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction.", + "output": "negative regulation of heart induction by canonical Wnt signaling pathway (negative regulation of heart induction)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the assembly of pseudopodia.", + "output": "regulation of pseudopodium formation (regulation of plasma membrane bounded cell projection assembly)" + }, + { + "input": "Definition: Surgical Equipment described as devices used to hold tissue structures together for repair, reconstruction or to close wounds. They may consist of adsorbable or non-adsorbable, natural or synthetic materials. They include tissue adhesives, skin tape, sutures, buttons, staples, clips, screws, etc., each designed to conform to various tissue geometries.", + "output": "Devices, Surgical Fixation (Medical Device)" + }, + { + "input": "Definition: Abnormality of renal glomerulus morphology described as a hardening of the kidney glomerulus caused by scarring of the blood vessels.", + "output": "Glomerulosclerosis, NOS (Kidney Diseases)" + }, + { + "input": "Definition: therapeutic autologous dendritic cells described as a cell-based vaccine composed of autologous-monocyte-derived dendritic cells (DCs) loaded with five immunogenic peptide epitopes, derived from the tumor-associated antigen human folate receptor alpha (FR alpha or FOLR1), including FR30, FR56, FR76, FR113, and FR238, with potential immunomodulatory and antineoplastic activity. Ex vivo treatment of the DCs with a p38 inhibitor decreases p38-mediated signaling and enhances ERK activation. This may allow, upon intradermal administration of the multi-epitope FR alpha-loaded DC vaccine into the patient, for decreased activation and expansion of CD4+ regulatory T-cells (Tregs), increased differentiation and expansion of interleukin-17 secreting T helper cells (Th17) and activation of CD8+ CTLs, which induces a strong anti-tumor T-cell immune response against FR alpha-overexpressing tumor cells. FR alpha is a high-affinity folate-binding protein and a member of the folate receptor family; this receptor is overexpressed in the majority of ovarian cancers and in about approximately 50% of breast cancers.", + "output": "Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine (therapeutic autologous dendritic cells)" + }, + { + "input": "Definition: Microwave Surgical Units described as microwave surgical units that use needle-like antennas for energy radiation. These units include a microwave generator typically of 100-watt energy and 2.45 GHz frequency, a coaxial cable to transmit the energy, and needle radiators (i.e., antennas). The needles are positioned surrounding the tissue to be resected (e.g., tumor), power is applied successively to each needle creating a continuous boundary of coagulated tissue surrounding the tumor; hemostasis of vessels up to 2 mm in diameter is possible. The tumor is removed using a scalpel or an electrosurgical unit. Needle microwave radiator surgical units are used in open surgery of the liver and spleen; they are also used in endoscopic and laparoscopic surgical applications (e.g., to control bleeding in the digestive tract).", + "output": "Microwave Surgical Units, Needle Radiator (Medical Device)" + }, + { + "input": "Definition: Body Location or Region described as one of three parts of area 22a of Vogts defined on the basis of cytoarchitecture and myeloarchitecture in the guenon. It differs from area 22a alpha of Vogts and area 22a beta of Vogts in that its layer III is widest and its layer IV is thinner and less cellular than in the other two parts ( Vogts-1919 ).", + "output": "Area 22a gamma (area 22a of Vogts)" + }, + { + "input": "Definition: Spatial Concept described as denoting the area of the body in front and toward the cranium, brain, and eye.", + "output": "ANTEROTEMPORAL (Anatomy Qualifier)" + }, + { + "input": "Definition: Intellectual Product described as work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years.", + "output": "Patent (Publication Formats)" + }, + { + "input": "Definition: Spatial Concept described as of, or related to, or in the direction of the face.", + "output": "Facial (Spatial Concept)" + }, + { + "input": "Definition: Cell Component described as the component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", + "output": "extrinsic component of mitochondrial inner membrane (extrinsic component of organelle membrane)" + }, + { + "input": "Definition: glycerol metabolic process described as the chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.", + "output": "glycerol biosynthetic process (alditol biosynthetic process)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.", + "output": "negative regulation of signaling receptor activity (regulation of signaling receptor activity)" + }, + { + "input": "Definition: transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein].", + "output": "phosphate:acyl-[acyl carrier protein] acyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: Pharmacologic Substance described as a dialkyl ether dicarboxylic acid with antihyperlipidemic activity. In animal models gemcabene increased high density lipoprotein (HDL) cholesterol levels and increased HDL particle size. Low-density lipoprotein cholesterol, trigylcerides, and apolipoprotein C-III levels were decreased as well. In human test subjects, the HDL lowering effect of gemcabene was only seen in patients with high (>200 mg/dl) levels of triglycerides.", + "output": "gemcabene (Pharmacologic Substance)" + }, + { + "input": "Definition: Antineoplastic Protein Inhibitor described as the mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.", + "output": "Obatoclax Mesylate (Organic Chemical)" + }, + { + "input": "Definition: something described as a ginglymoid (hinge) synovial joint within the first digit of the hand or foot articulating the proximal and distal phalanges.", + "output": "IP1 (Interphalangeal joint structure)" + }, + { + "input": "Definition: something described as proximal superior mesenteric lymph node group located around the trunk of inferior pancreaticoduodenal artery.", + "output": "JPS 14b node (Set of visceral abdominal lymph nodes)" + }, + { + "input": "Definition: Esotropia described as an intermittent esotropia with binocular single vision present at distance fixation but esotropia on accommodation for near fixation. Usually associated with hypermetropia but patients can be emmetropic and rarely myopic. Associated with a high accommodative convergence/accommodation (AC/A) ratio.", + "output": "Convergence excess esotropia (Esotropia with accommodative compensation)" + }, + { + "input": "Definition: Knee Joint, Leg: Repair described as a surgical procedure to replace part or all of a knee joint with an orthopedic prosthesis.", + "output": "Repair of knee joint (Musculoskeletal system repair)" + }, + { + "input": "Definition: Linolenic Acids described as a fatty acid that is found in plants and involved in the formation of prostaglandins.", + "output": "ALA (omega-3 fatty acids)" + }, + { + "input": "Definition: Professional or Occupational Group described as a Pediatrician who practices Sleep Medicine is certified in the subspecialty of sleep medicine and specializes in the clinical assessment, physiologic testing, diagnosis, management and prevention of sleep and circadian rhythm disorders. Sleep specialists treat patients of any age and use multidisciplinary approaches. Disorders managed by sleep specialists include, but are not limited to, sleep related breathing disorders, insomnia, hypersomnias, circadian rhythm sleep disorders, parasomnias and sleep related movement disorders.", + "output": "Allopathic & Osteopathic Physicians; Pediatrics, Sleep Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Extracellular Matrix Proteins described as fibrillin-2 (2912 aa, ~315 kDa) is encoded by the human FBN2 gene. This protein is involved in the structure of extracellular calcium-binding microfibrils.", + "output": "FBN2 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a mass of tissue that has been cut away from its surrounding areas for AUTOLOGOUS TRANSPLANTATION, but it remains attached to its original location via blood vessels only.", + "output": "Island Flaps (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as carboxypeptidase A1 (419 aa, ~47 kDa) is encoded by the human CPA1 gene. This protein plays a role in enzyme metabolism.", + "output": "Carboxypeptidase A1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Organ or Tissue Function described as the long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.", + "output": "axon extension involved in axon guidance (axon extension)" + }, + { + "input": "Definition: something described as susceptible to decreased ability to recover from perceived adverse or changing situations, through a dynamic process of adaptation, which may compromise health.", + "output": "Risk for impaired resilience (Coping responses)" + }, + { + "input": "Definition: Professional or Occupational Group described as an individual who is a Board Certified Specialist in Pediatric Critical Care Nutrition and applies evidence-based nutrition knowledge in providing medical nutrition therapy for critically ill infants, children and adolescents. Additional roles could include coordination, education, quality improvement, or research linked specifically to pediatric critical care nutrition.", + "output": "Dietary & Nutritional Service Providers; \"Dietitian, Registered\", \"Nutrition, Pediatric Critical Care\" (Professional or Occupational Group)" + }, + { + "input": "Definition: Hematological Disease described as the co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.", + "output": "Complication, Hematological Pregnancy (Pregnancy Complications)" + }, + { + "input": "Definition: Densovirus described as a genus of PARVOVIRIDAE, subfamily DENSOVIRINAE, comprising helper-independent viruses containing only two species. Junonia coenia densovirus is the type species.", + "output": "Insect parvovirus group, NOS (BACTERIAL, INSECT, PLANT AND OTHER VIRUSES)" + }, + { + "input": "Definition: something described as stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IA Fallopian Tube Carcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Rigidity Right Lower Extremity.", + "output": "UPD2-Rigidity RT Lower Extremity (MDS-UPDRS Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: arachidonate + O(2)=(5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.", + "output": "arachidonate 12(R)-lipoxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Mental Process described as emotional attachment to someone or something in the environment.", + "output": "Attachment, Object (Psychoanalytic Theory)" + }, + { + "input": "Definition: MSQOL-54 Questionnaire Question described as multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54) During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of any emotional problems: Cut down on the amount of time you could spend on work or other activities.", + "output": "MSQOL-54 - Emotional Problem Cut Down Time on Work (Intellectual Product)" + }, + { + "input": "Definition: something described as a hot/cold water bottle is a device intended for medical purposes that is in the form of a container intended to be filled with hot or cold water to apply heat or cold to an area of the body.", + "output": "hot water bottle (Single-Use Containers)" + }, + { + "input": "Definition: something described as a suspension of service (especially of radio or tv broadcasting).", + "output": "Blackout (Conceptual Entity)" + }, + { + "input": "Definition: Benign germ cell neoplasm described as a rare teratoid tumor of the ovary composed almost entirely of thyroid tissue, with large follicles containing abundant colloid. Occasionally there are symptoms of hyperthyroidism. 5-10% of struma ovarii become malignant, the only absolute criterion for which is the presence of metastasis.", + "output": "STRUMA OVARII (Benign Ovarian Neoplasm)" + }, + { + "input": "Definition: something described as human INHBE wild-type allele is located in the vicinity of 12q13.3 and is approximately 7 kb in length. This allele, which encodes inhibin beta E chain protein, is involved in the modulation of hormone secretion.", + "output": "Inhibin, Beta E Gene (INHBE gene)" + }, + { + "input": "Definition: something described as the process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink.", + "output": "phloem loading (phloem transport)" + }, + { + "input": "Definition: Professional or Occupational Group described as a Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, autonomic nervous system, and blood vessels that relate to these structures.", + "output": "Allopathic & Osteopathic Physicians; Psychiatry & Neurology, Neurology (Professional or Occupational Group)" + }, + { + "input": "Definition: unclassified Nitrobacter described as a genus of gram-negative, rod-shaped bacteria that oxidizes nitrites to nitrates. Its organisms occur in aerobic environments where organic matter is being mineralized, including soil, fresh water, and sea water.", + "output": "Nitrobacter species (Nitrobacter)" + }, + { + "input": "Definition: Flu Like Symptoms, CTCAE described as mild flu-like symptoms present", + "output": "Grade 1 Flu Like Symptoms, CTCAE (Finding)" + }, + { + "input": "Definition: Intellectual Product described as marked bridging fibrosis with formation of occasional hepatic nodules is present.", + "output": "Ishak Score 5 (Ishak Score)" + }, + { + "input": "Definition: Abnormality of the calf musculature described as enlargement of the muscles of the calf due to their replacement by connective tissue or fat.", + "output": "Calf muscle pseudohypertrophy (Finding)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H(2)O + triacetate lactone = triacetate.", + "output": "triacetate-lactonase activity (Molecular Function)" + }, + { + "input": "Definition: Abnormality of the epiphysis of the distal phalanx of the 3rd finger described as sclerosis of the epiphysis of the distal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.", + "output": "Increased bone density of end part of the outermost middle finger bone (Ivory epiphyses of the distal phalanges of the hand)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.", + "output": "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity (protein kinase activity)" + }, + { + "input": "Definition: Neurologic visual problems NEC described as blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details.", + "output": "blurry vision (Abnormality of vision)" + }, + { + "input": "Definition: pre-miRNA described as MIR7-1 pre-miRNA is an oligonucleotide that is encoded by the human MIR7-1 gene and has a role in the regulation of gene expression.", + "output": "MIR7-1 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Molecular Function described as any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.", + "output": "positive regulation of protein kinase C signalling cascade (positive regulation of intracellular signal transduction)" + }, + { + "input": "Definition: something described as a country in the Pacific, occupying an island in the South Pacific Ocean, east of Australia.", + "output": "NORFOLK ISLAND (Country)" + }, + { + "input": "Definition: Pharmacologic Substance described as sulphate of iron.", + "output": "Ferrum sulphuricum / iron sulphate (Inorganic Chemical)" + }, + { + "input": "Definition: something described as a change in the nucleotide sequence of an FGFR family gene that that results in constitutive activation the encoded fibroblast growth factor receptor protein and its downstream signaling pathways.", + "output": "Activating Fibroblast Growth Factor Receptor Gene Mutation (FGFR Gene Mutation)" + }, + { + "input": "Definition: toluene described as a dye that has been used as an industrial dye, a laboratory indicator, and a biological stain.", + "output": "Blue, Tetrabromophenol (Phenols)" + }, + { + "input": "Definition: Finding described as a disorder characterized by the presence of blood in a fallopian tube.", + "output": "Hematosalpinx, CTCAE (Reproductive System and Breast Disorders, CTCAE)" + }, + { + "input": "Definition: something described as surgery to remove part of one ovary or part of both ovaries.", + "output": "Oophorectomy partial (Ovariectomy)" + }, + { + "input": "Definition: Gene or Genome described as the human MIR135B wild-type allele is located in the vicinity of 1q32.1 and is approximately 97 bases in length. This allele, which encodes MIR135B pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with highly invasive non-small-cell lung cancer.", + "output": "mir-135b (Gene or Genome)" + }, + { + "input": "Definition: Ptosis described as the presence of prolapse of the uterus.", + "output": "prolapse of uterus (Visceral Prolapse)" + }, + { + "input": "Definition: Phototherapy described as the use of infrared radiation to heat a specific tissue for the purpose of treating an injury or illness.", + "output": "Radiant heat: infrared:physio. (Electromagnetic energy therapy)" + }, + { + "input": "Definition: Organ or Tissue Function described as the cell differentiation process that results in commitment of a cell to become part of the endoderm.", + "output": "endodermal cell fate commitment (cell fate commitment involved in formation of primary germ layer)" + }, + { + "input": "Definition: Organic Chemical described as a radioconjugate and cationic lipophilic agent consisting of fluorobenzyl triphenyl phosphonium (FBnTP), labeled with the radioisotope fluorine F 18, with potential use as a tracer for both mitochondrial membrane potential (MMP) and apoptosis, and as a tumor imaging agent using positron emission tomography (PET). Upon administration, fluorine F 18 FBnTP is taken up by cells and its uptake and accumulation within mitochondria is directly correlated with MMP. Apoptosis causes a loss of membrane potential across the inner mitochondrial membrane which decreases FBnTP mitochondrial uptake. As apoptosis is suppressed in tumor cells, the FBnTP uptake is increased as compared to normal cells. This allows, upon PET, for the imaging of cancer cells. As apoptosis-inducing chemotherapeutic agents cause a collapse of MMP, this agent can also be used to assess the response of tumor cells to those chemotherapeutic agents.", + "output": "(18)F-FBnTP (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: DataType described as a data type comprised an enumeration of a set of unordered, quantitative simple values.", + "output": "QSS (Qualitative Concept)" + }, + { + "input": "Definition: metabolism by organism of carbohydrate in other organism involved in symbiotic interaction described as the chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "metabolism by symbiont of host carbohydrate (metabolism by organism of carbohydrate in other organism involved in symbiotic interaction)" + }, + { + "input": "Definition: Alphaproteobacteria described as a family of gram-negative methanotrophs in the order Rhizobiales, distantly related to the nitrogen-fixing and phototrophic bacteria.", + "output": "alpha methylotroph group 1 (Alphaproteobacteria)" + }, + { + "input": "Definition: something described as stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage I Exocrine Pancreatic Carcinoma AJCC v8 (Pancreatic Cancer by AJCC v8 Stage)" + }, + { + "input": "Definition: Disease or Syndrome described as condition in which there is a deviation or interruption in the processing of proteins in the body: synthesis, absorption, transport, storage, and utilization.", + "output": "Disorder of protein metabolism (Metabolic Diseases)" + }, + { + "input": "Definition: something described as this gene is involved in transcriptional activation and spinal cord development.", + "output": "ETV1 (ETS Family Gene)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.", + "output": "ommochrome metabolic process (eye pigment metabolic process)" + }, + { + "input": "Definition: something described as a measurement of the cytochrome P450 2C9 enzyme activity in a biological specimen.", + "output": "Cytochrome P450 2C9 Activity Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Gene or Genome described as human VEGFB wild-type allele is located in the vicinity of 11q13 and is approximately 4 kb in length. This allele, which encodes vascular endothelial growth factor B protein, is involved in both endothelial cell proliferation and angiogenesis.", + "output": "VEGFL (VEGFB gene)" + }, + { + "input": "Definition: something described as an enzyme that in the course of pyrimidine biosynthesis, catalyzes the oxidation of dihydro-orotic acid to orotic acid utilizing oxygen as the electron acceptor. This enzyme is a flavoprotein which contains both FLAVIN-ADENINE DINUCLEOTIDE and FLAVIN MONONUCLEOTIDE as well as iron-sulfur centers. EC 1.3.3.1.", + "output": "(S)-Dihydroorotate:oxygen oxidoreductase (Enzyme)" + }, + { + "input": "Definition: developmental process involved in reproduction described as construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell.", + "output": "eggshell chorion assembly (external encapsulating structure organization)" + }, + { + "input": "Definition: Identifier described as SOP Instance UID of a DICOM Modality Performed Procedure Step (MPPS) or General Purpose Performed Procedure Step (GPPPS).", + "output": "Performed Procedure Step SOP Instance UID (Identifier)" + }, + { + "input": "Definition: Aplasia/Hypoplasia of the fibula described as underdevelopment of the fibula.", + "output": "Hypoplastic fibula (Finding)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis.", + "output": "Stage IV Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8 (Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage)" + }, + { + "input": "Definition: something described as an orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration.", + "output": "GTx-758 (Pharmacologic Substance)" + }, + { + "input": "Definition: Ophthalmic Sites Cancer TNM Finding v8 described as a finding about one or more characteristics of orbital sarcoma, following the rules of the TNM AJCC v8 classification system. This classification does not apply to osseous and cartilaginous tumors arising in bone (are staged according to the classification for bone), secondary tumors that arise in adjacent periorbital sites with orbital invasion (are staged according to the classification for primary site of tumor), lacrimal gland carcinomas (are staged according to the classification for lacrimal gland carcinoma), and lacrimal gland sarcomas (are staged according to the classification for soft tissue sarcoma of the head and neck). There is no proposal for anatomic stage and prognostic groups for orbital sarcomas at this time.", + "output": "Orbital Sarcoma TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Health Care Activity described as the first identified case or patient in a communicable disease outbreak.", + "output": "Epidemiology, Index Case (Health Care Activity)" + }, + { + "input": "Definition: something described as the Cancer Center Support Grant (P30) is an NCI grant to help fund designated centers' infrastructure of administration and core facilities.", + "output": "P30 Cancer Center Support Grant (NCI Program)" + }, + { + "input": "Definition: Vitamin measurement described as the determination of the amount of Vitamin B5 present in a sample.", + "output": "Vitamin B5 Measurement (Vitamin measurement)" + }, + { + "input": "Definition: Cell Component described as a protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.", + "output": "RPAP3/R2TP/prefoldin-like complex location (protein-containing complex)" + }, + { + "input": "Definition: Medical Device described as surgical clamps designed to atraumatically grasp the liver during open-surgery procedures. These clamps typically are handheld, manual instruments including two parts pivoted at the center with very long and slightly curved distal blades and handles that include a ratchet mechanism. Some clamps have a locking device at the distal end. Dedicated liver clamps are available for liver transplant and/or for resection of portions of the liver.", + "output": "Liver Clamps, Surgical (Surgical Clamps)" + }, + { + "input": "Definition: something described as a wild-type zebrafish line that is polymorphic relative to the Tubingen line.", + "output": "WIK Zebrafish (Fish)" + }, + { + "input": "Definition: something described as an abnormality of the Maxilla (upper jaw bone).", + "output": "Malformation of the maxilla (Abnormal jaw morphology)" + }, + { + "input": "Definition: Visual acuity test equipment described as a diagrammatic method to test visual acuity, which uses a chart containing 11 lines of Sloan optotypes in varying sizes with the largest located at the top of the chart and decreasing in size toward the bottom of the chart.", + "output": "Visual acuity chart (Ophthalmic examination and evaluation)" + }, + { + "input": "Definition: something described as an ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.", + "output": "Ku autoantigen (Serology)" + }, + { + "input": "Definition: cellular process described as any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.", + "output": "cellular detoxification (cellular process)" + }, + { + "input": "Definition: something described as a formulation of the mustard plant Brassica juncea grown in a medium that has been enriched with the trace element selenium with potential chemopreventive and chemopotentiating activities. Brassica juncea hyperaccumulates trace elements in soil. Selenium amino acid species found in selenized Brassica juncea include methylselenomethionine (MeSeMet) and methylselenocysteine (MeSeCys); both may be incorporated into selenoproteins in vivo. Selenium functions as a cofactor for antioxidant enzymes such as glutathione peroxidases and thioredoxin reductase, which protect cells from the free radical damage. In addition, in vitro MeSeCys has been shown to potentiate the antitumor effects of the irinotecan metabolite SN-38, by inducing phosphorylation of checkpoint kinase 2 (chk2) at threonine 68, which results in poly(ADP-ribose) polymerase cleavage, caspase 3 activation, and DNA fragmentation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71154\" active clinical trials using this agent.", + "output": "High-Selenium Brassica juncea (Pharmacologic Substance)" + }, + { + "input": "Definition: CoA-ligase activity described as catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA.", + "output": "biotinyl-CoA synthetase activity (CoA-ligase activity)" + }, + { + "input": "Definition: NATURAL PHYSICAL FORCES described as a vertical distance measured from a known level on the surface of a planet or other celestial body.", + "output": "Altitude, NOS (Quantitative Concept)" + }, + { + "input": "Definition: Retina and choroid finding described as lack of the foveal reflex, which normally occurs as a result of the reflection of light from the ophthalmoscope in the foveal pit upon examination. The foveal reflex is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.", + "output": "Absent foveal reflex (Macula finding)" + }, + { + "input": "Definition: Medical Device described as laser delivery systems consisting of flexible or rigid hollow tubes (i.e., waveguides) appropriated for delivery of laser energy from the laser source to the tissue, typically at infrared wavelengths,.", + "output": "Waveguides (Medical Device)" + }, + { + "input": "Definition: Lymphatic system disorders NEC described as a painful sensation in a lymph node.", + "output": "pain in lymph node (Lymphatic system disorders NEC)" + }, + { + "input": "Definition: South America described as a country in southwestern South America, bordering the South Pacific Ocean, between Argentina and Peru.", + "output": "CL (Affiliate Realms)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's rating of the average amount of fatigue they have felt in the past seven days.", + "output": "In The Past 7 Days How Would You Rate Your Fatigue On Average (Intellectual Product)" + }, + { + "input": "Definition: Covers described as covers designed to fit over or within bedpans to provide a protective barrier between the bedpan and a patient's skin. Bedpan covers are made of plastic for disposal after use, or of a biodegradable and flushable material. Some bedpan covers include an anti-odor absorbent pad or waste treatment powder that absorbs liquid waste and turns it into an odorless, spill-proof gel.", + "output": "Covers, Bedpan (Medical Device)" + }, + { + "input": "Definition: Microscopy technique described as microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.", + "output": "Fluorescence Light Microscopy (Microscopy technique)" + }, + { + "input": "Definition: something described as a provider who is educated and trained in a system of therapeutics in which diseases are treated by drugs which are capable of producing in healthy persons symptoms like those of the disease to be treated. Treatment requires administering a drug in minute doses.", + "output": "Other Service Providers; Homeopath (HealthcareProviderTaxonomyHIPAA - CodeSystem)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+.", + "output": "3-hydroxymenthone dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: EGFR NP 005219.2:p.G796X described as a change in the amino acid residue at position 796 in the epidermal growth factor receptor protein where glycine has been replaced by serine.", + "output": "EGFR G796S (EGFR NP 005219.2:p.G796X)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll.", + "output": "regulation of chlorophyll metabolic process (regulation of tetrapyrrole metabolic process)" + }, + { + "input": "Definition: host cell cytoplasm part described as the volume enclosed by the membranes of the host cell endoplasmic reticulum.", + "output": "host endoplasmic reticulum lumen (Cell Component)" + }, + { + "input": "Definition: Blood Gas Analysis described as a measurement of the oxygen-hemoglobin saturation of a volume of blood.", + "output": "Oxygen saturation (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: Pharmacologic Substance described as a proprietary, personalized plasmid DNA-based cancer vaccine composed of a live-attenuated strain of the Gram-positive bacterium Listeria monocytogenes (Lm) carrying a proprietary plasmid vector encoding multiple, patient-specific, immunogenic neoepitopes fused to a truncated form of the immunostimulant listeriolysin O (tLLO), with potential immunostimulatory and antineoplastic activities. Upon administration of the Lm-tLLO-neoantigens vaccine ADXS-NEO, the ADXS-NEO is taken up by antigen presenting cells (APCs), such as dendritic cells (DCs), and the expressed tLLO-neoantigens fusion protein is processed and presented to the immune system by both major histocompatibility complex (MHC) I and II molecules. This activates the immune system to exert both innate and adaptive immune responses involving the recruitment and activation of T lymphocytes against the tumor-associated antigens (TAAs) specifically expressed by the patient's tumor cells, and inhibits the immunosuppressive tumor-infiltrating T-regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME). This results in tumor cell lysis. The various unique mutation-derived TAAs that are used in ADXS-NEO are identified from a biopsy of the patient's tumor. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148380\" active clinical trials using this agent.", + "output": "neoepitope-based Immunotherapeutic ADXS-NEO (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Total Body Clearance by Fraction of Dose for Dose Interval described as the total body clearance for extravascular administration for dose interval based on the fraction of dose absorbed and divided by the body mass index.", + "output": "Total CL by F for Dose Int Norm by BMI (Total Body Clearance by Fraction of Dose for Dose Interval)" + }, + { + "input": "Definition: Inflammatory disorder of head described as infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA.", + "output": "candidiasis; thrush (Oral mucosal fungal disease)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radioconjugate containing the acetate salt of eribulin, labeled with the beta particle-emitting radioisotope carbon C 14, with radioisotopic and potential antineoplastic activities. Upon administration, eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. The radioisotope moiety of this agent acts as a radioactive tracer.", + "output": "carbon C 14 eribulin acetate (Radioconjugate)" + }, + { + "input": "Definition: Reusable Devices described as small transparent enclosures designed to keep objects in storage free from moisture. Most desiccators consist of a two-piece glass enclosure, the lower portion of which includes a rim to hold a ceramic sample plate that has several holes over a desiccant agent (e.g., silica gel) and that is placed on the bottom; the cover is adjusted to ensure an airtight seal commonly using grease or silicone O-rings on the contact flanges. Some desiccators include an opening in the cover for a rubber stopper with a hole to apply a vacuum pump for fast moisture removal. Desiccators are mostly used to store anhydrous and hygroscopic chemicals and/or biological compounds in clinical laboratories.", + "output": "Desiccators (Laboratory instruments and equipment)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus.", + "output": "response to L-cysteine (Organism Function)" + }, + { + "input": "Definition: Allergen class described as a centrally acting skeletal muscle relaxant with antidepressant activity. The exact mechanism of action of cyclobenzaprine has not been fully determined, but this drug seems to primarily act at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons leading to a reduction in muscle spasms.", + "output": "Product containing cyclobenzaprine (Organic cyclic compound)" + }, + { + "input": "Definition: something described as performance of the Upper Limb Module for DMD Version 1.2 - Shoulder abduction above shoulder height.", + "output": "PUL01-Shoulder Abduction Above Shldr Hgt (Intellectual Product)" + }, + { + "input": "Definition: something described as a type of Pap test. A Pap test is a procedure in which cells are scraped from the cervix for examination under a microscope. It is used to detect cancer or changes that may lead to cancer. A Pap test can also show conditions that are not cancer, such as infection or inflammation. In a liquid-based Pap test, the cells are rinsed into a small container of liquid. The cells are then placed onto slides by a special machine and examined under a microscope to see if the cells are abnormal.", + "output": "Liquid-based Pap Test (Laboratory Procedure)" + }, + { + "input": "Definition: Remote location new client without ICD diagnosis described as using Ayurvedic assessment methods in a detailed, 30-minute, out-of-office meeting to assess the health status of a new Ayurvedic medicine client and develop an Ayurvedic treatment plan. Use for client/patient assessment and/or history.", + "output": "new30+min out-ofc Ayvdcmed (Remote location new client without ICD diagnosis)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of fludarabine that may be used in the treatment of Waldenstrom's macroglobulinemia (WM) and lymphoplasmacytic lymphoma (LPL).", + "output": "Fludarabine Phosphate Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how much an individual's blurry vision interfered with their usual or daily activities over the past seven days.", + "output": "Past Seven Days How Much Blurry Vision Interfered with Usual or Daily Activities (Intellectual Product)" + }, + { + "input": "Definition: Dental Procedures described as treatment of the gums, soft tissues, and bones that support the teeth.", + "output": "Periodontal Procedure (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Organic Chemical described as garden rue.", + "output": "ruta graveolens/garden rue (Organic Chemical)" + }, + { + "input": "Definition: Symptomatology described as a neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).", + "output": "extrapyramidal symptom (Abnormal central motor function)" + }, + { + "input": "Definition: FACT-Taxane Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Taxane Version 4 - Social/Family Well-Being: I am satisfied with family communication about my illness.", + "output": "FAC06312 (Intellectual Product)" + }, + { + "input": "Definition: MSQOL-54 Questionnaire Question described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Have you been a very nervous person?", + "output": "MSQL1-Have Been a Very Nervous Person (MSQOL-54 Questionnaire Question)" + }, + { + "input": "Definition: Nitriles described as a highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.", + "output": "Cyanide, Vinyl (OTHER NITROGENOUS COMPOUNDS)" + }, + { + "input": "Definition: Other anomalies of uterus described as underdevelopment of the uterus.", + "output": "Small uterus (Congenital Abnormality)" + }, + { + "input": "Definition: Cell Component described as a multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species.", + "output": "plasma membrane succinate dehydrogenase complex location (plasma membrane protein complex)" + }, + { + "input": "Definition: regulation of Toll signaling pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.", + "output": "downregulation of Toll signaling pathway (Molecular Function)" + }, + { + "input": "Definition: Protein kinase inhibitors, antineoplastic drugs described as a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.", + "output": "ridaforolimus (Protein kinase inhibitors, antineoplastic drugs)" + }, + { + "input": "Definition: something described as an oligosaccharide protein modification that is synthesized by insect cells.", + "output": "INSECT TYPE GLYCAN (Organic Chemical)" + }, + { + "input": "Definition: Isertieae described as a plant genus. Members contain pyrocincholic acid.", + "output": "Isertia (Plant)" + }, + { + "input": "Definition: Yao language - Bantu described as a Niger-Congo Bantu language spoken by the Luba people in the Democratic Republic of the Congo.", + "output": "Luba-Shaba (Yao language - Bantu)" + }, + { + "input": "Definition: KSR1 gene described as human KSR1 wild-type allele is located in the vicinity of 17q11.1 and is approximately 77 kb in length. This allele, which encodes kinase suppressor of ras-1 protein, is involved in the regulation of transcription via the MAPK/Erk signaling cascade.", + "output": "KSR1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Chromosome 10 Physical Location described as physical location of BTAF1_Gene", + "output": "10: 93673716-93779349 (Chromosome 10 Physical Location)" + }, + { + "input": "Definition: something described as a meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.", + "output": "Net, Nerve (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that are common in the marine environment and on the surfaces and in the intestinal contents of marine animals. Some species are bioluminescent and are found as symbionts in specialized luminous organs of fish.", + "output": "Photobacterium species (Vibrio)" + }, + { + "input": "Definition: Actions by primitive described as eradicating all or a portion of a body part", + "output": "Destruction (Actions by primitive)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles.", + "output": "cuticle chitin metabolic process (chitin metabolic process)" + }, + { + "input": "Definition: UNC13D gene described as human UNC13D wild-type allele is located in the vicinity of 17q25.1 and is approximately 17 kb in length. This allele, which encodes protein unc-13 homolog D protein, plays a role in the regulation of cytolytic granule secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3.", + "output": "Unc-13 Homolog D (C. elegans) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Renal Disorder described as molecular assay reagents intended to identify variants in the majority of genes known to be associated with renal disorders, a collection of conditions involving structural or functional deficits of the kidneys. Genetic variants at multiple loci have been associated with renal disorders. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in the majority of renal disorder-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Renal Disorder, Comprehensive (Medical Device)" + }, + { + "input": "Definition: Benign neoplasm of esophagus described as a non-metastasizing encapsulated neoplasm arising from nerves in the esophagus. Morphologically, it is characterized by the presence of fibroblasts and Schwann cells.", + "output": "neurofibroma of esophagus (Malignant neoplasm of esophagus)" + }, + { + "input": "Definition: Diagnostic Procedure described as an observation made on the contents of the animal's housing environment (e.g., presence of blood, vomit).", + "output": "CAGE OBSERVATION (Observation - diagnostic procedure)" + }, + { + "input": "Definition: Carcinoma of ampulla of Vater described as a carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made.", + "output": "Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma (Carcinoma of ampulla of Vater)" + }, + { + "input": "Definition: Enzyme described as myeloblastin (256 aa, ~28 kDa) is encoded by the human PRTN3 gene. This protein is involved in the proteolysis of extracellular matrix proteins.", + "output": "C-ANCA (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Gastrointestinal Disorders, CTCAE described as a disorder characterized by inflammation of the lip.", + "output": "Cheilitis, CTCAE (Adverse Event Associated with Dermatology and Skin)" + }, + { + "input": "Definition: Pegivirus described as b strain causes hepatitis in tamarins and possibly humans; putative etiological agent of GB hepatitis.", + "output": "hgv (Flavivirus)" + }, + { + "input": "Definition: something described as a Foster Care Agency is an agency that provides foster care as defined in the Code of Federal Regulations (CFR) as \"24-hour substitute care for children outside their own homes.\" Foster care settings include, but are not limited to, nonrelative foster family homes, relative foster homes (whether payments are being made or not), group homes, emergency shelters, residential facilities, and pre-adoptive homes.", + "output": "Agencies; Foster Care Agency (Health Care Related Organization)" + }, + { + "input": "Definition: Governmental or Regulatory Activity described as administrative control and monitoring mechanisms, such as for the implementation of local, regional or national planning acts, design codes, heritage or conservation policies and environmental planning policy, that govern the planning, design, development and maintenance of open space, including rural, suburban and urban land, parks, conservation areas and wildlife reserves.", + "output": "Open space planning systems (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Amino Acid Sequence described as a sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown to be present, in a conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length.", + "output": "EGF-Like Domain (Amino Acid Sequence)" + }, + { + "input": "Definition: something described as cocoa, chocolate.", + "output": "chocolate (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as patient Health Questionnaire Screener Version - In the last 3 months have you often done any of the following in order to avoid gaining weight: Took more than twice the recommended dose of laxatives to avoid gaining weight?", + "output": "PHQ03-Took Twice Dose of Laxatives (Intellectual Product)" + }, + { + "input": "Definition: Malignant Neoplasms described as chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.", + "output": "Leukemia, myelomonocytic (Blood, Heart and Circulation)" + }, + { + "input": "Definition: nuclear-transcribed mRNA catabolic process described as a minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.", + "output": "mRNA breakdown, endonucleolytic cleavage-dependent decay (Genetic Function)" + }, + { + "input": "Definition: something described as nasal cavity and ethmoid sinus cancer with very advanced local disease. Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.", + "output": "Nasal Cavity and Ethmoid Sinus Cancer pT4b TNM Finding v7 (Nasal Cavity and Ethmoid Sinus Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Qualitative Concept described as used with animals, higher plants, organs, and diseases for parasitic factors. In diseases, it is not used if the parasitic involvement is implicit in the diagnosis.", + "output": "parasitology (Etiology aspects)" + }, + { + "input": "Definition: negative regulation of mitotic cytokinetic process described as any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly.", + "output": "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis (negative regulation of cytokinesis, actomyosin contractile ring assembly)" + }, + { + "input": "Definition: Organic Chemicals described as a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.", + "output": "DOXEPIN (Tricyclic Antidepressive Agents)" + }, + { + "input": "Definition: Finding described as problems associated with the improper combination of materials or elements present in the device (e.g. improper composition of the materials of a capacitor).", + "output": "Device Improper Composition/Concentration (Device Evaluation Result)" + }, + { + "input": "Definition: something described as any nematode parasite that can be assigned to the species Trichostrongylus axei.", + "output": "Trichostrongylus axei (Trichostrongylus)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bartonella Species, DNA described as molecular assay reagents intended to identify Bartonella henselae, a rod-shaped bacterium of the family Bartonellaceae, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target bacteria. These bacteria may cause benign lymphoreticulosis (cat-scratch disease) and regional lymphadenitis.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bartonella henselae, DNA (Medical Device)" + }, + { + "input": "Definition: something described as a clinical assessment tool designed to evaluate the risk for chemotherapy toxicity in geriatric cancer patients. The tool captures sociodemographics, tumor and treatment variables, laboratory test results, and geriatric assessment domains.", + "output": "Cancer and Aging Research Group Chemo Toxicity Calculator (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Imaging of brain abnormal described as an anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS).", + "output": "Abnormal metabolic brain imaging by MRS (Finding)" + }, + { + "input": "Definition: SUPERFICIAL INJURIES, BURNS AND CONTUSIONS described as generic burn injury, including that due to excessive heat, as well as cauterization, friction, electricity, radiation, sunlight, and other causes", + "output": "burning lesions (Examination of skin)" + }, + { + "input": "Definition: something described as a measurement of the toxigenic strain of Clostridium difficile in a biological specimen.", + "output": "TOXCDF (Clostridium difficile Measurement)" + }, + { + "input": "Definition: mating type switching donor selection described as the activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.", + "output": "activation of recombination (Cell Function)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris.", + "output": "culmorin biosynthetic process (sesquiterpene biosynthetic process)" + }, + { + "input": "Definition: something described as administering a chelating solution to a client/patient through a vein for therapeutic effect(s) (for example, to bind and eliminate detrimental materials in the blood). Service is billed in 60-minute increments.", + "output": "Intravenous chelation therapy administration each 60 minutes (Miscellaneous substance administration)" + }, + { + "input": "Definition: something described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum) to determine one or more of the group of hormones and other substances (e.g., C-peptide, glucogen) that modulate the regulation of glucose concentration in blood.", + "output": "IVD Test Reagent/Kits, Immunoassay, Diabetes (IVD Test Reagent/Kits, Immunoassay)" + }, + { + "input": "Definition: Organ or Tissue Function described as seeing functions of sensing size, form and contour, using both eyes, for objects distant from the eye.", + "output": "Binocular acuity of distant vision (Visual acuity functions)" + }, + { + "input": "Definition: Unit of Electric Permittivity described as a SI unit of electric permittivity.", + "output": "Farad per Meter (Unit of Electric Permittivity)" + }, + { + "input": "Definition: stomach pylorus smooth muscle contraction described as a process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum.", + "output": "pyloric sphincter smooth muscle contraction (stomach pylorus smooth muscle contraction)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "output": "retina development in camera-type eye (anatomical structure development)" + }, + { + "input": "Definition: adenoma of extrahepatic bile duct described as an adenoma that arises from the extrahepatic bile ducts. It is characterized by the presence of a tubular pattern.", + "output": "Tubular Adenoma of the Extrahepatic Bile Duct (Benign neoplasm of extrahepatic bile ducts)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.", + "output": "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity (UDP-galactosyltransferase activity)" + }, + { + "input": "Definition: Cell Component described as the side of the cell wall that is opposite to the side that faces the cell and its contents.", + "output": "external side of cell wall (Cell Component)" + }, + { + "input": "Definition: Virus described as a strain of DUCK ADENOVIRUS A.", + "output": "Egg drop syndrome virus (Aviadenovirus)" + }, + { + "input": "Definition: something described as compounds based on benzeneacetamide, that are similar in structure to ACETANILIDES.", + "output": "Benzeneacetamides (Acetamides)" + }, + { + "input": "Definition: Oils, Volatile described as any elsewhere undefined essential oil, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "undef.essential oil narr req (Oils, Volatile)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as the biotoxin botulinum neurotoxin E6.", + "output": "Clostridium botulinum Toxin E6 (Pharmacologic Substance)" + }, + { + "input": "Definition: Ear structure described as median longitudinal ear length less than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear.", + "output": "Short ear (Finding)" + }, + { + "input": "Definition: Venous tree organ described as venous tree (organ) connected to the right atrium. Examples: superior vena caval tree, inferior vena caval tree, main cardiac venous tree", + "output": "Systemic venous tree organ (Body System)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of the Beta-2 glycoprotein 1 IgG antibodies in a sample.", + "output": "B2G1GGAB (Laboratory Procedure)" + }, + { + "input": "Definition: something described as swelling (edema) of the retinal nerve fibers. []", + "output": "Retinal nerve fiber edema (Pathologic Function)" + }, + { + "input": "Definition: Finding described as multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic.", + "output": "MULTIFOCAL ATRIAL TACHYCARDIA (Atrial arrhythmia)" + }, + { + "input": "Definition: something described as instruments designed to remove cells or tissues from a surface or cavity, spread materials on a surface, or mix materials. Spatulas typically consist of a metallic (e.g., stainless steel) or plastic handheld instrument, with a straight or curved thin, flat, blunt distal working tip. Some spatula handles have working tips on both ends. Dedicated spatulas are available to mix dental and orthopedic cements and other compounds, for superficial removal of cells for cytology, and to manipulate and/or dissect tissues during surgical procedures.", + "output": "spatula (Surgical Equipment, Ophthalmological)" + }, + { + "input": "Definition: Essential morphological unit described as a circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.", + "output": "haversian system (Bone part)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.", + "output": "regulation of TRAIL receptor biosynthetic process (regulation of receptor biosynthetic process)" + }, + { + "input": "Definition: Ocular Prosthesis described as an eye sphere implant is a device intended to be implanted in the eyeball to occupy space following the removal of the contents of the eyeball with the sclera left intact.", + "output": "Prosthesis of eyeball (Ocular Prosthesis)" + }, + { + "input": "Definition: Receptor described as beta-3 adrenergic receptor (408 aa, ~44 kDa) is encoded by the human ADRB3 gene. This protein plays a role in G protein-coupled receptor signaling, lipolysis, and thermogenesis.", + "output": "Beta-3-Adrenoceptor (Receptor)" + }, + { + "input": "Definition: Finding described as specifies whether result values should be excluded from the statistical analysis.", + "output": "EXCLFL (Finding)" + }, + { + "input": "Definition: Document type described as a record used to track Regulatory activities during the course of a clinical trial.", + "output": "Regulatory Tracking Document (Document type)" + }, + { + "input": "Definition: purine deoxyribonucleoside triphosphate biosynthetic process described as the chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate.", + "output": "dGTP synthesis (dGTP metabolic process)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the ANKRD26 gene.", + "output": "ANKRD26 Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as carcinoma of the eyelid with no evidence of a primary tumor.", + "output": "Carcinoma of the Eyelid pT0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54) During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health: Were limited in the kind of work or other activities.", + "output": "MSQL115 (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant.", + "output": "positive regulation of HR (positive regulation of programmed cell death)" + }, + { + "input": "Definition: something described as any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "positive regulation by symbiont of indole acetic acid levels in host (positive regulation by symbiont of hormone or growth regulator levels in host)" + }, + { + "input": "Definition: Finding described as a subjective score of 1 on a severity scale that ranges from 0: Not at all severe to 10: most severe.", + "output": "Severity Score 1 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Intellectual Product described as presence of fibrosis and tumor cells with preponderance of tumor cells.", + "output": "Tumor Regression Grade 4 (Intellectual Product)" + }, + { + "input": "Definition: Somesthetic Perception described as recognition and discrimination of the heaviness of a lifted object.", + "output": "Weight Perception (Mental Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as proteins involved in the transport of NUCLEOSIDES across cellular membranes.", + "output": "Transport Proteins, Nucleoside (Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins)" + }, + { + "input": "Definition: something described as catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate.", + "output": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: alpha-amino acid metabolic process described as the chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.", + "output": "hypusine metabolism (Molecular Function)" + }, + { + "input": "Definition: Quantitative Concept described as a measurement of the range of values seen in the time interval between the beginning and end of the pulse wave. This is usually calculated at the point where the amplitude is at 50% of the wave peak.", + "output": "SIGW (Quantitative Concept)" + }, + { + "input": "Definition: something described as a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs.", + "output": "Dicrofenac (Anti-Inflammatory Agents, Non-Steroidal)" + }, + { + "input": "Definition: Haemophilus haemolyticus described as any bacterial organism that can be assigned to the species Haemophilus haemolyticus and is beta-lactamase negative.", + "output": "Haemophilus haemolyticus, Beta-Lactamase Negative (Bacterium)" + }, + { + "input": "Definition: Dental arch width described as linear measurement of the distance or width between cuspid teeth.", + "output": "Distance between cuspid teeth (Finding)" + }, + { + "input": "Definition: C-SSRS Lifetime/Recent Version Questionnaire Question described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Have you had these thoughts and had some intention of acting on them? (Past 1 Month).", + "output": "CSS11-Idea, Intent, No Plan-P1M (Intellectual Product)" + }, + { + "input": "Definition: something described as TPN or hospitalization indicated; invasive intervention indicated", + "output": "Grade 3 Anal Necrosis, CTCAE (Anal Necrosis, CTCAE)" + }, + { + "input": "Definition: something described as organ segment which is regional part of submandibular gland. Examples: submandibular duct tree, submandibular duct.", + "output": "Segment of sublingual gland (Segment of salivary gland)" + }, + { + "input": "Definition: Genus Fusobacterium described as any bacterial organism that can be assigned to the species Fusobacterium varium.", + "output": "Fusobacterium varium (Eggerth and Gagnon 1933) Moore and Holdeman 1969 (Bacterium)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).", + "output": "sodium:iodide symporter activity (Molecular Function)" + }, + { + "input": "Definition: Auditory Threshold described as loss of sensitivity to sounds as a result of auditory stimulation, manifesting as a temporary shift in auditory threshold. The temporary threshold shift, TTS, is expressed in decibels.", + "output": "auditory fatigue (Auditory Threshold)" + }, + { + "input": "Definition: Benign neoplasm of face described as a non-metastasizing neoplasm that arises from the ethmoid sinus.", + "output": "Benign Neoplasm of Ethmoid Sinus (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE RESPIRATORY SYSTEM)" + }, + { + "input": "Definition: something described as a mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA1 gene. Single nucleotide substitutions and small deletions or insertions (1-20 bases) account for the majority of mutations in the BRCA1 gene. Approximately 75% of these alterations result in a truncated form of the breast cancer type 1 susceptibility protein. Mutations in the BRCA1 gene predispose individuals to breast and ovarian cancers.", + "output": "BRCA1 Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the nasal septum.", + "output": "Abnormality of the nasal septum (Congenital anomaly of nose)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as a moist powder tobacco product that is used by placing it under the upper lip for extended periods.", + "output": "Snus (Smokeless Tobacco)" + }, + { + "input": "Definition: Chronic hemolytic anemia described as mixed autoimmune hemolytic anemia (mixed AIHA) is a type of autoimmune hemolytic anemia defined by the presence of both warm and cold autoantibodies, which have a deleterious effect on red blood cells at either body temperature or at lower temperatures. Diagnosis is based on clinical or laboratory evidence of hemolytic anemia and the detection of autoantibodies, usually both IgG and IgM, with the direct anti-globulin test (DAT) showing a pattern of IgG with complement C3, and the presence of cold agglutinins (IgM) in the serum at a significant titer. The disease responds to corticosteroids, and may be followed by remission, but usually runs a chronic course with intermittent exacerbations.", + "output": "Autoimmune hemolytic anemia mixed type (Cold Hemagglutinin Disease)" + }, + { + "input": "Definition: something described as no longer able to be activated or utilized.", + "output": "Disabled (Qualitative Concept)" + }, + { + "input": "Definition: negative regulation of cell adhesion described as the disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction.", + "output": "substrate-bound cell migration, cell release from substrate (Cell Function)" + }, + { + "input": "Definition: Abnormality of urine homeostasis described as an increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.", + "output": "Elevated urinary delta-aminolevulinic acid (Finding)" + }, + { + "input": "Definition: Childhood Central Nervous System Embryonal Neoplasm described as a central nervous system embryonal tumor, not otherwise specified that occurs in childhood.", + "output": "Central Nervous System Embryonal Tumor, NOS (Neoplastic Process)" + }, + { + "input": "Definition: Primary Indicator described as specifies whether this is the main or principal document identifier.", + "output": "Document Identifier Primary Indicator (Primary Indicator)" + }, + { + "input": "Definition: Expanded DRS-PI Survivor Version Questionnaire Question described as expanded Disability Rating Scale - Postacute Interview Survivor Version (Expanded DRS-PI Survivor Version) Can you keep track of time, schedules and appointments?", + "output": "Expanded DRS-PI Survivor Version - Keep Track of Time (Intellectual Product)" + }, + { + "input": "Definition: something described as a medicinal product that is currently authorised for marketing in a country or region, that is related to the specific needs of the clinical trial as described in the protocol, but not as an investigational medicinal product, regardless of labelling of the auxiliary medicinal product.", + "output": "authorised auxiliary medicinal product (Biologically Active Substance)" + }, + { + "input": "Definition: something described as use of a rotary drum, belt, or other moving filter to purify a slurry.", + "output": "Moving Filter Filtration (Laboratory Procedure)" + }, + { + "input": "Definition: Fetus with drug damage described as an umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.", + "output": "Fetal Alcohol Spectrum Disorder (Fetal or neonatal effect of maternal use of alcohol)" + }, + { + "input": "Definition: Cranial Nerves described as the inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.", + "output": "Ganglion inferius (Structure of cranial nerve ganglion)" + }, + { + "input": "Definition: Intellectual Product described as mini-Mental State Examination - What is this: Object 1?", + "output": "MMSE - Naming Object 1 (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.", + "output": "up-regulation of transforming growth factor-beta3 production (Organism Function)" + }, + { + "input": "Definition: Emotions described as sadness resulting from being isolated or alone.", + "output": "Feeling lonely (Finding)" + }, + { + "input": "Definition: membrane activity described as a process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.", + "output": "exocytosis (vesicle-mediated transport)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as a molecular genetic technique that isolates and sequences chromosomal regions that are rich in open chromatin. First, nuclei are harvested from a cellular sample. Then a hyperactive Tn5 transposase is added to the nuclei where it excises non-nucleosomal DNA strands and ligates co-administered high-throughput sequencing adapters (tagmentation). The tagged DNA fragments are isolated, amplified by PCR and sequenced. The number of reads for specific region of DNA correlate with increased chromatin accessibility and this method can identify regions of transcription factor and nucleosome binding.", + "output": "Assay for Transposase Accessible Chromatin with High-Throughput Sequencing (DNA analysis)" + }, + { + "input": "Definition: Illness described as a set of symptoms or conditions that occur together and suggest the presence of a certain disease or an increased chance of developing the disease.", + "output": "syndrome (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: CYP2D6 gene described as human CYP2D6*41 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*41 protein. The CYP2D6*41 allele exhibits clinically-relevant SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence decrease the enzymatic activity of the cytochrome P450 2D6*41 protein.", + "output": "CYP2D6*41 (CYP2D6 gene)" + }, + { + "input": "Definition: something described as the date and time span for when the healthcare provider is active.", + "output": "HealthcareProvider.effectiveDateRange (Effective Date Range)" + }, + { + "input": "Definition: something described as a facial cleft extending from the zygomatic arch to the eye. This zygomaticomaxillary cleft is similar to that typically found in Treacher Collins syndrome. The overlying tissue shows a vertical sclerodermic furrow radiating from the labial commissure or the angle of the mandible across the cheek to a coloboma of the lower eyelid between the middle and lateral one-third. Microphthalmia is not observed. The skeletal cleft is between the maxilla and zygoma; it passes through the inferolateral orbital rim to enter the inferior orbital fissure. No alveolar cleft is present. The zygomatic arch is intact. The soft tissue furrow, which is more apparent on the right, radiates from the oral commissure toward the lateral two-thirds of the lower eyelid. The antimongoloid obliquity of the palpebral fissures is associated with laterally placed lower eyelid clefts and some ectropion. A left-sided anophthalmia is accompanied by adjacent soft tissue hypoplasia and is reflected in a short palpebral fissure, enophthalmos, and minor ptosis of the eyebrow. No abnormality is present in the alveolar arch except for some tilting of the occlusal plane secondary to hypoplasia of the left side of the maxilla. There is a vertical bony groove in the region of the zygomaticomaxillary suture that ends in the inferolateral portion of a small bony orbit. More laterally, the remainder of the zygomatic body and arch is normal in both shape and dimension. The lateral orbital floor is downslanting but intact, and it lacks direct communication with the temporal or infratemporal fossae. The hypoplasia of the left side of the maxilla and orbit is associated with a reduction in the transverse and anteroposterior dimensions of the anterior cranial fossa; mild asymmetry of the middle cranial fossa and calvarium is present. No significant asymmetry of size, shape, or position is present in the sphenoid.", + "output": "Tessier number 6 facial cleft (Congenital Abnormality)" + }, + { + "input": "Definition: something described as a method of euthanasia whereby a subject is given a lethal injection and the body is drained of blood.", + "output": "LETHAL INJECTION EXSANGUINATION (Euthanasia Method)" + }, + { + "input": "Definition: Sign or Symptom described as the location of the chest pain is along the left middle border of the sternum.", + "output": "Chest Pain Along Left Middle Sternal Border (Sign or Symptom)" + }, + { + "input": "Definition: something described as a multiple congenital anomaly/mental retardation syndrome characterized by a short stature, large head, hypotonia with or without joint contractures, seizures, imperforate anus, agenesis of the corpus callosum, and characteristic facies. \"FG\" stands for the surnames of patients in whom the syndrome was first reported.", + "output": "KELLER SYNDROME (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as the series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.", + "output": "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification (Molecular Function)" + }, + { + "input": "Definition: Pharmaceutical Product Characteristics described as the composition of a dosage form, including the characteristics of its raw materials and the operations required to process it.Formulation factors include chemical nature of the drug (ester, salt, complex, etc), drug solubility in water and organic solvents, particle size and surface area, type of dosage form (solution, suspension, capsule, tablet) and the excipients and processes used in the manufacturing of the drug delivery systems. The design of optimal drug delivery systems is thus an important part of providing an effective therapeutic.Official formulations for approved agents are presented in such books as the National Formulary and US Pharmacopeia. Whereas at one time, these were detailed and almost recipe-like, more recent entries may be limited to specifying the formula and imposing a standard limit for the active agent.", + "output": "Pharmaceutical Formulation (Conceptual Entity)" + }, + { + "input": "Definition: something described as aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.", + "output": "Dihydrodiol Dehydrogenase 3 (Hydroxyprostaglandin Dehydrogenases)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide.", + "output": "pheophytin pheophorbide hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as a disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.", + "output": "Cerebrospinal Fluid Leakage (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as choline dehydrogenase, mitochondrial (594 aa, ~65 kDa) is encoded by the human CHDH gene. This protein is involved in the conversion of choline to betaine.", + "output": "CHD (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions and duplications in genes associated with neurofibromatosis, a collection of genetic disorders characterized by the formation of tumors in the nervous system. Genetic variants at multiple loci have been associated with neurofibromatosis. These reagents are intended to detect deletions and duplications in multiple neurofibromatosis-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Rasopathies, Neurofibromatosis Syndrome, Del/Dup (IVD Panels, Human Genetics, Rasopathies, Neurofibromatosis Syndrome)" + }, + { + "input": "Definition: Neoplastic Process described as a rare adenoma that arises from the intrahepatic biliary tree.", + "output": "intrahepatic; adenoma bile duct (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)" + }, + { + "input": "Definition: Ophthalmic cannula described as eye cannulae or handpieces used to create a channel between the anterior chamber of the eye and the subarachnoidal space in the treatment of glaucoma.", + "output": "Cannulae, Eye, Cyclodialysis (Medical Device)" + }, + { + "input": "Definition: Stent/Grafts, Vascular described as stent/grafts designed for percutaneous deployment into the coronary arteries. These devices typically consist of a metallic (e.g., balloon expandable) meshlike stent covered with a synthetic graft such as Dacron or polytetrafluoroethylene (PTFE). Some devices consist of a layer of expanded PTFE placed between two stainless steel stents. Coronary stent/grafts are intended for emergency treatment of perforations in native coronary arteries and/or saphenous vein bypass grafts.", + "output": "Coronary Stent/Grafts (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.", + "output": "Low Sperm Count (Sperm count decreased)" + }, + { + "input": "Definition: Finding described as a broad spectrum of other macroreentrant tachycardias in which the wave front does not travel around the tricuspid annulus. Atypical atrial flutter originates from the left atrium or areas in the right atrium (such as surgical scars) and has a variable appearance on ECG in regards to the flutter waves.", + "output": "atrial flutter atypical (Finding)" + }, + { + "input": "Definition: something described as a cystic lesion that has more than one compartment.", + "output": "Multilocular Lesion (Finding)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - During the last week, has it been easy or hard for your child to: Turn door knobs?", + "output": "PODCI132 (PODCI Pediatric Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Immunologic Factor described as c-X-C motif chemokine 3 (107 aa, ~11 kDa) is encoded by the human CXCL3 gene. This protein plays a role in neutrophil chemotaxis.", + "output": "chemokine (C-X-C motif) ligand 3 protein, human (Immunologic Factor)" + }, + { + "input": "Definition: Protein Binding described as interacting selectively and non-covalently with a domain within the same polypeptide.", + "output": "protein self association (Protein Binding)" + }, + { + "input": "Definition: Supportive care described as the use of video, audio, and other methods of telecommunicating to monitor a patient's health status from a site distant to the patient.", + "output": "health telemonitoring (Supportive care)" + }, + { + "input": "Definition: something described as events of lasting impact or importance occurring in the 17th century.", + "output": "Historical Events, 17th Century (Activity)" + }, + { + "input": "Definition: something described as detoxified aggregate of cholera toxin formed by heat treatment of purified cholera toxin.", + "output": "Procholeragenoid (Immunologic Factor)" + }, + { + "input": "Definition: Neoplastic Process described as a rare acute myeloid leukemia that occurs in childhood. It is characterized by t(6;11)(q27;q23) which results in KMT2A-MLLT4 fusion. It is associated with an unfavorable prognosis.", + "output": "Acute Myeloid Leukemia (AML) with t(6;11)(q27;q23); KMT2A-MLLT4 (Childhood Acute Myeloid Leukemia)" + }, + { + "input": "Definition: cevimeline described as a drug used to treat certain disorders of the salivary gland. It is also being studied as a treatment for dry mouth caused by radiation therapy to the head and neck. It increases the amount of saliva and sweat made by saliva and sweat glands. Cevimeline hydrochloride is a type of cholinergic agonist.", + "output": "cevimeline hcl (Pharmacologic Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as mucin-16 (22152 aa, ~2353 kDa) is encoded by the human MUC16 gene. This protein may be involved in both cellular adhesion and the lubrication of mucosal surfaces.", + "output": "MUC16 (mucins)" + }, + { + "input": "Definition: Arisaemateae described as a plant genus of the family ARACEAE. It has a stemless, tuberous root.", + "output": "Arisaemas (Plant)" + }, + { + "input": "Definition: something described as an indication or description that respiratory data is a baseline value.", + "output": "Respiratory System Findings Baseline Flag (Functional Concept)" + }, + { + "input": "Definition: something described as timers designed to measure the duration of each step of cleaning and disinfection of the hands and arms performed at a scrub station. These timers consist of time measuring instruments that may use mechanical, electromechanical, or electronic technologies and audible signal generators (e.g., buzzers) to indicate that the time needed for a particular scrubbing operation has elapsed; some timers may include outputs to the control circuits that operate the water supply, ultraviolet lamps, or other station devices. Scrub station timers are frequently an integral part of the station.", + "output": "Scrub Station Timers (Medical Device)" + }, + { + "input": "Definition: Geographic Area described as a state in north western Mexico on the Gulf of California. Its capital is Hermosillo.", + "output": "Sonora (Geographic Area)" + }, + { + "input": "Definition: something described as the textual representation of the experimental unit allocation result. EXAMPLE(S): In SDTM, the TABRANCH variable may contain a description such as \"Randomized to Placebo - 5 mg - 10 mg\", \"Randomized to Drug A\", \"Assigned to Rescue on basis of response evaluation\". OTHER NAME(S): NOTE(S):", + "output": "PlannedExperimentalUnitAllocationResult.description (Intellectual Product)" + }, + { + "input": "Definition: Sugar Phosphates described as an ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate.", + "output": "GLUCOSE PHOSPHATE A 06 (Glucosephosphates)" + }, + { + "input": "Definition: SIQ Questionnaire Question described as suicidal Ideation Questionnaire - Specific standardization %: Sample 3.", + "output": "SIQ0135 (SIQ Questionnaire Question)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the maximum concentration of thrombin generated during a thrombin generation test.", + "output": "Endogenous Thrombin Potential Peak Height (Blood coagulation tests)" + }, + { + "input": "Definition: regulation of inner ear auditory receptor cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.", + "output": "negative regulation of inner ear auditory receptor cell differentiation (negative regulation of inner ear receptor cell differentiation)" + }, + { + "input": "Definition: Biologically Active Substance described as lamin-A/C (646 aa, ~72 kDa) is encoded by the human LMNA gene. This protein plays a role in the formation of the nuclear lamina.", + "output": "Lamin A C (Biologically Active Substance)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the World Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "WD7TN (Intellectual Product)" + }, + { + "input": "Definition: cellular response to organic cyclic compound described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus.", + "output": "cellular response to indolebutyric acid stimulus (cellular response to organonitrogen compound)" + }, + { + "input": "Definition: Los Angeles Classification System described as mucosal breaks that extend between the tops of two or more mucosal folds, but which involve less than 75% of the esophageal circumference.", + "output": "LA Grade C (Los Angeles Classification System)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination.", + "output": "down regulation of mesodermal cell fate determination (negative regulation of cell fate determination)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as lymphocyte activation gene 3 protein (525 aa, ~57 kDa) is encoded by the human LAG3 gene. This protein is involved in the activation of T-cells and natural killer cells.", + "output": "LAG3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Lower respiratory tract infection viral described as viral disorder characterized by high fever, dry cough, shortness of breath (dyspnea) or breathing difficulties, and atypical pneumonia, a virus in the genus cornonavirus is the suspected causative agent.", + "output": "SARS assoc coronavirus (Disease or Syndrome)" + }, + { + "input": "Definition: MRI - musculoskeletal structures described as magnetic resonance imaging of bone.", + "output": "Bone MRI (MRI - musculoskeletal structures)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.", + "output": "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity (bisphosphoglycerate phosphatase activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a humanized, agonistic monoclonal antibody against P selectin glycoprotein ligand-1 (PSGL-1; SELPLG; CD162), with potential immunosuppressive activity. Upon administration, neihulizumab specifically targets and binds to CD162 expressed on activated T-lymphocytes. This induces apoptosis of activated T-cells and reduces T-cell-mediated immune responses. This may halt disease progression of T-cell-mediated autoimmune diseases and acute graft-versus-host disease (GvHD).", + "output": "neihulizumab (Immunologic Factor)" + }, + { + "input": "Definition: Lower respiratory fluid described as the fluid that is abnormally collected in the pleural cavity.", + "output": "Pleural fluid, NOS (Biospecimen)" + }, + { + "input": "Definition: Hospitalization & Institutionalization described as persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.", + "output": "Out-patient (Patient or Disabled Group)" + }, + { + "input": "Definition: Disease due to Gram-positive bacteria described as a chronic granulomatous inflammation involving the deep dermis and the subcutaneous tissues. It is caused by Actinomycetes bacteria.", + "output": "infection; mycetoma, actinomycotic (Disorder of skin of lower limb)" + }, + { + "input": "Definition: Intellectual Product described as mayo-Portland Adaptability Inventory-4 - Focusing on thinking, physical or emotional problems attributed to brain injury; rate only how concern or worry about these symptoms affects current functioning over and above the effects of the symptoms themselves.", + "output": "MPAI-4 - Adjustment: Sensitivity to Mild Symptoms (MPAI-4 Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure expressed in microgram(s) per dose.", + "output": "ug/dose (Unit of Dose Calculation)" + }, + { + "input": "Definition: Educational Activity described as performing activities involved in completing a programme requirement or another evaluation process relevant to obtaining a preschool education.", + "output": "Progressing in preschool educational programme (Educational Activity)" + }, + { + "input": "Definition: Adenocarcinoma of breast described as the most common type of breast cancer. It begins in the cells that line the milk ducts in the breast.", + "output": "BREAST CANCER DUCTAL (Neoplastic Process)" + }, + { + "input": "Definition: something described as a written agreement for the transfer of patients and their medical records from one health care institution to another.", + "output": "Transfer Agreement (Intellectual Product)" + }, + { + "input": "Definition: Adrenergic Agonists described as the hydrochloride salt form of isoproterenol, a synthetic catechol compound and potent beta adrenergic agonist with peripheral vasodilator, bronchodilator, and cardiac stimulating properties. Isoproterenol exerts its effect on the beta-1 adrenergic receptors in the myocardium, thereby increasing heart rate and cardiac output. In addition, isoproterenol acts on beta-2 adrenergic receptors in bronchiolar and vascular smooth muscle, thereby causing smooth muscle relaxation.", + "output": "Isoprenaline hydrochloride (isoproterenol)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the biosynthesis of second messenger molecules.", + "output": "PHOSPHOLIPASE C, BETA-4 (Gene or Genome)" + }, + { + "input": "Definition: Body surface point described as an anatomic point, as defined by the Standard Acupuncture Nomenclature, that can be stimulated via various techniques, including the insertion and withdrawal of needles, the application of heat, massage, laser, electrical pulsation, or a combination of these methods.", + "output": "Acupuncture point (Body Location or Region)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a natural analogue of actinomycin, a chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin C2 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms including, intercalating into the minor groove of DNA and interfering with the function of topoisomerase II. In addition, actinomycin C2 appears to block the interaction between the SH2 domain of growth factor receptor-bound protein-2 (GRB2) and the Src homology 2 domain containing transforming protein 1 adaptor protein SHC, which plays a key role in the Ras signaling pathway thereby halting cellular differentiation and proliferation.", + "output": "actinomycin C(2) (Actinomycin)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.", + "output": "Secondary Amine Oxidoreductases (Enzyme)" + }, + { + "input": "Definition: Azocines described as one ring heterocyclic compounds defined by C6H7NO. Permitted are any degree of hydrogenation, any substituents and any ortho-fused or ortho-peri-fused ring systems.", + "output": "Oxazocines (Azocines)" + }, + { + "input": "Definition: something described as human B4GALT1 wild-type allele is located in the vicinity of 9p13 and is approximately 63 kb in length. This allele, which encodes beta-1,4-galactosyltransferase 1 protein, is involved in lactose synthesis. Mutation of the gene is associated with congenital disorder of glycosylation type 2D.", + "output": "GGTB2 (Gene or Genome)" + }, + { + "input": "Definition: Mammals described as the cat family in the order CARNIVORA comprised of muscular, deep-chested terrestrial carnivores with a highly predatory lifestyle.", + "output": "Felid (Mammals)" + }, + { + "input": "Definition: something described as increase or decrease in niacin content of the diet. Treatment for prevention of pellagra.", + "output": "Niacin modified diet (Modified vitamin diet)" + }, + { + "input": "Definition: Mouth region part described as the soft tissue on the lateral aspects of the face, generally bounded by the eyes, nose, ear, and jaw line.", + "output": "CHEEK (Head and Neck Part)" + }, + { + "input": "Definition: Cation Channel Blocker described as the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.", + "output": "Ibutilide fumarate (Organic Chemical)" + }, + { + "input": "Definition: Microorganism described as any anaerobic bacteria that metabolizes complex carbohydrates to produce butyrate. These microorganisms may form colonies in the intestines of mammals; their presence may aid the host by catabolizing undigested fiber and starch. Additionally, butyrate is metabolized by colonic epithelial cells and may protect the host against ulcerative colitis and cancer.", + "output": "BPB (Organism)" + }, + { + "input": "Definition: Central Nervous System described as the sensation of struggling to remain awake.", + "output": "Drowsiness (Symptoms)" + }, + { + "input": "Definition: something described as physical location of CD3D_Gene", + "output": "11: 117718669-117714999 (Spatial Concept)" + }, + { + "input": "Definition: positive regulation of cellular amine metabolic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.", + "output": "positive regulation of catecholamine metabolism (positive regulation of cellular amine metabolic process)" + }, + { + "input": "Definition: something described as a compound forming white, odorless deliquescent crystals and used as iodine supplement, expectorant or in its radioactive (I-131) form as an diagnostic aid, particularly for thyroid function tests.", + "output": "Sodium iodide (Sodium Compounds, Inorganic)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of bone cancer, following the rules of the TNM AJCC v7 classification system. The clinical staging includes all relevant data prior to primary definitive therapy, including physical examination, imaging, and biopsy.", + "output": "Bone Cancer Clinical TNM Finding v7 (Bone Cancer TNM Finding v7)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids.", + "output": "cinnamic acid biosynthetic process involved in flavonoid metabolism (cinnamic acid biosynthetic process)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days, for how many days were you totally unable to carry out your usual activities or work because of any health condition?", + "output": "WHODAS 2.0 36-item Version Self-administered - Days Unable to Carry Out Activities (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as generation of an extra copy of a particular gene in the genome. A gene duplication abnormality may occur by gene amplification, random breakage and reunion, retrotransposition or unequal crossing-over at meiosis. A gene duplication abnormality can be either heritable or somatic.", + "output": "Gene Duplication (Gene Amplification Abnormality)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein.", + "output": "histone demethylase activity (Molecular Function)" + }, + { + "input": "Definition: Publications described as promotional labeling is generally any labeling other than the FDA-required labeling that is devised for promotion of the product. Promotional labeling may include items such as \"brochures, booklets, mailing pieces, detailing pieces, file cards, bulletins, calendars, price lists, catalogs, house organs, letters, motion picture films, film strips, lantern slides, sound recordings, exhibits, literature, and reprints and similar pieces of printed, audio, or visual matter . . .\" See 21 CFR 202.1(l)(2).", + "output": "Promotional Labeling (Intellectual Product)" + }, + { + "input": "Definition: Office manager described as an employee charged with the general administrative responsibilities of any given office of a corporation or business, responsible for all paperwork, including its filing and retention over time, and the supervision of office staff.", + "output": "Office Manager (Office manager)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Control described as reagents consisting of samples of substances with known values; they are used for quality control of immunoassay tests performed to measure levels of one or more of a group of therapeutic drugs in a specimen (e.g., serum, plasma, whole blood) collected from a patient.", + "output": "IVD Test Reagent/Kits, Immunoassay, Control, Therapeutic Drug (IVD Test Reagent/Kits, Immunoassay, Control)" + }, + { + "input": "Definition: Verification described as confirming the accuracy, authenticity, and thoroughness of a primary record by comparing it to original evidence and reports.", + "output": "Source Document Verification (Verification)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a murine monoclonal antibody directed against the CD5 antigen and labeled with Yttrium-90, a beta-emitting radioisotope. CD5 is a type-I transmembrane glycoprotein found on thymocytes, T-cells and a subset of B-cells. Yttrium 90 monoclonal antibody T101 may bind to and selectively irradiate and kill CD5-positive tumor cells. Yttrium 90 has a half-life of 2.5 days and can be administered on an outpatient basis.", + "output": "MOAB YT-90 T101 (Radioimmunoconjugates)" + }, + { + "input": "Definition: Kidney Infection, CTCAE described as oral intervention indicated", + "output": "Grade 2 Kidney Infection, CTCAE (Kidney Infection, CTCAE)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.", + "output": "regulation of homocysteine metabolism (regulation of sulfur amino acid metabolic process)" + }, + { + "input": "Definition: Vasoconstrictor Agents described as a mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.", + "output": "co dergocrine (Organic Chemical)" + }, + { + "input": "Definition: Cesarean section described as a cesarean delivery scheduled at a patient's request or provider preference without medical or obstetric indications.", + "output": "Elective cesarian deliv NOS (Cesarean section)" + }, + { + "input": "Definition: Anatomic structures described as anatomical structure present after birth.", + "output": "Postnatal anatomical structure (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: indolalkylamine catabolic process described as the chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.", + "output": "tryptophan catabolism (aromatic amino acid family catabolic process)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(6;22)(p21;q12) which fuses the first six exons of the EWSR1 gene to exon 2 of the POU5F1 gene. This rearrangement is associated with hidradenoma and one case of mucoepidermoid carcinoma of the salivary glands.", + "output": "EWS/POU5F1 Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Functional assessment described as a standardized rating scale developed by Mathias et al in 1986 which is used to test basic mobility skills in frail elderly persons and other populations such as people with arthritis, stroke, and vertigo. This functional test measures the time in seconds for a person to stand up from a standard armchair, walk 3 meters, turn, walk back to the chair, and sit down again. Scoring of this test is based on the average of multiple completed and timed trials.", + "output": "Timed up and go (Diagnostic Procedure)" + }, + { + "input": "Definition: Multipotent Stem Cells described as mesenchymal stem cells, also referred to as multipotent stromal cells or mesenchymal stromal cells are multipotent, non-hematopoietic adult stem cells that are present in multiple tissues, including BONE MARROW; ADIPOSE TISSUE; and WHARTON JELLY. Mesenchymal stem cells can differentiate into mesodermal lineages, such as adipocytic, osteocytic and chondrocytic.", + "output": "Mesenchymal cell (Stromal Cells)" + }, + { + "input": "Definition: Medical Device described as a speculum is a device intended to be inserted into a body cavity to aid observation. It is either nonilluminated or illuminated and may have various accessories.", + "output": "SPECULUM, ENT (Medical Device)" + }, + { + "input": "Definition: Language described as a Mongolic language that is regarded as either a dialect of Mongolian or a distinct language.", + "output": "Oirat (Language)" + }, + { + "input": "Definition: something described as an organization that enters into a contract with the acquirer for the supply of a system, software product, or software service under the terms of a contract.", + "output": "Computer System or Software Supplier (Suppliers)" + }, + { + "input": "Definition: Hereditary disorder of immune system described as syndrome with characteristics of a specific natural-killer cell deficiency and susceptibility to viral diseases. It has been described in four children from a large inbred kindred. Three out of the four children reported developed a viral illness. The mode of transmission is most likely autosomal recessive. The causative gene is within a 12-Mb region on chromosome 8p11.23-q11.21.", + "output": "Primary immunodeficiency with natural killer cell deficiency and adrenal insufficiency (Hereditary disorder of immune system)" + }, + { + "input": "Definition: Vaccines, Peptide described as a peptide vaccine containing the amino acids 267 through 274 of the human immunodeficiency virus type 1 (HIV-1) gag core protein (gag:267-274), with potential immunostimulating activity. Upon vaccination, the immune system may exert a potent cytotoxic T-lymphocyte (CTL) response against the xenoantigen gag:267-274 and produces pro-inflammatory cytokines. The concomitant administration of a cancer peptide vaccine may benefit from an already activated immune system and may augment an immune response against the administered tumor associated antigen(s). Gag:267-274 peptide is highly immunogenic and may potentially be used as a cancer immunoadjuvant.", + "output": "Gag:267-274 peptide vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as the 1.0 version of the CDISC Diabetes therapeutic area user guide ADaM supplement.", + "output": "Diabetes Therapeutic Area User Guide v1.0 - Supplement for ADaM (Intellectual Product)" + }, + { + "input": "Definition: Protein Family described as a family of glycosylphosphatidylinositol (GPI)-anchored proteins that are involved in forward and reverse cell-cell signaling through binding to ephrin-A receptors (EPHA).", + "output": "Ephrin-A Family (Protein Family)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as organizing term for the Proteins tree", + "output": "Proteins [By Function] (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Mental Process described as process through which psychophysical excitations form themselves into an integrated stable field or gestalt; the arrangements of elements of personality in an integrated complex.", + "output": "self organization (Personality)" + }, + { + "input": "Definition: Antineoplastic Antibody-Drug Conjugate described as a targeted antibody drug conjugate (ADC) consisting of a human monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated to the cytotoxic agent maytansinoid mertansine (DM1), with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of AVID100 binds to and inhibits EGFR on tumor cell surfaces. Inhibition of EGFR prevents EGFR-mediated signaling and may inhibit tumor cell proliferation. Following receptor internalization, the mertansine moiety binds to tubulin and interferes with microtubule assembly/disassembly dynamics. This inhibits both cell division and proliferation of cancer cells that express EGFR. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148507\" active clinical trials using this agent.", + "output": "anti-EGFR/DM1 antibody-drug conjugate AVID100 (Immunoconjugates)" + }, + { + "input": "Definition: Lentigo maligna melanoma described as the reemergence of lentigo maligna after a period of remission", + "output": "Lentigo Maligna Recurrent (Lentigo maligna melanoma)" + }, + { + "input": "Definition: Malignant Childhood Neoplasm described as a malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.", + "output": "Osteosarcoma - disorder (Malignant osseous and chondromatous tumor morphology)" + }, + { + "input": "Definition: Authorized Osteopathic Thesaurus described as the act of feeling with the hand.", + "output": "Palpation (Examination by method)" + }, + { + "input": "Definition: Health Care Related Organization described as a facility that stores blood or blood products for transfusion under specific controlled conditions prior to shipping it to the final user.", + "output": "Blood Products Distribution Center (Clinical Services)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Protein described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (typically serum) to determine immunoglobulin A (IgA), approximately 10% to 15% of total immunoglobulin in normal serum. IgA is also found as secretory IgA (it includes two molecules of IgA) in tears, saliva, milk, and sweat. Increased levels of IgA in serum are associated with respiratory, renal, and skin infections.", + "output": "IVD Test Reagent/Kits, Immunoassay, Protein, Immunoglobulin A (Medical Device)" + }, + { + "input": "Definition: something described as freshwater, annelid worms of the family hirudinidae (e.g., Hirudo medicinalis, Macrobdella decora) that secrete in their saliva compounds with anti-coagulant properties (e.g., hirudin). Medical leeches may be used to promote localized bleeding to address venous congestion, typically occurring as a consequence of traumatic injury or reconstructive surgical procedures. Live leeches are placed on the skin overlying the area of venous congestion, and their feeding promotes circulation within the underlying tissue.", + "output": "Hirudo medicinalis (Eukaryote)" + }, + { + "input": "Definition: something described as life Events Checklist for DSM-5 Standard Version test name.", + "output": "Life Events Checklist for DSM-5 Standard Version Questionnaire Test Name (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as the research hospital for the NIH, the Federal Government's principal agency for biomedical research. The NIH Clinical Center is actually made up of two centers: the Warren Grant Magnuson Clinical Center and the Mark O. Hatfield Clinical Research Center. The Clinical Center as a whole promotes translational research, that is, the transformation of scientific laboratory research into applications that benefit patient health and medical care. At the Center, patient care units are in close proximity to cutting-edge technologies and laboratories doing related research. This \"bench-to-bedside\" approach facilitates interaction and collaboration among clinicians and researchers. The Clinical Center supports clinical trials conducted by the 27 Institutes and Centers of the NIH, including the National Cancer Institute (NCI).", + "output": "NIH Clinical Center (Organization)" + }, + { + "input": "Definition: Bacterium described as a group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.", + "output": "Gram Negative Aerobic Rods and Cocci (Bacterium)" + }, + { + "input": "Definition: Prognostic Stage III Breast Cancer AJCC v8 described as stage IIIA includes: (T0-1, N1, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative); (T0-1, N1, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T0-1, N1, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T2, N0, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative); (T2, N0, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N0, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T2, N1, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T2, N1, M0, G2, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G3, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G3, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T3, N0, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T3, N0, M0, G2, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G3, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G3, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T0-2, N2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Negative, ER Status: Negative, PR Status: Positive); (T0-2, N2, M0, G2, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); ( T0-2, N2, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T3, N1-2, M0, G1, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G1, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T3, N1-2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G1, HER2 Status: Negative, ER Status: Negative, PR Status: Positive); (T3, N1-2, M0, G2, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T4, N0-2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Positive); (Any T, N3, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Positive). T0: No evidence of primary tumor. T1: Tumor measuring 20 mm or less in greatest dimension. T2: Tumor measuring more than 20 mm, but not more than 50 mm in greatest dimension. T3: Tumor measuring more than 50 mm in greatest dimension. T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or macroscopic nodules); invasion of the dermis alone does not qualify as T4. N0: No regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only. N1: Tumor with micrometastases; or metastases in 1-3 axillary lymph nodes; and/or clinically negative internal mammary nodes with micrometastases or macrometastases by sentinel lymph node biopsy. N2: Tumor with metastases in 4-9 axillary lymph nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the absence of axillary lymph node metastases. N3: Tumor with metastases in 10 or more axillary lymph nodes; or in infraclavicular (level III axillary) lymph nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the presence of one or more positive level I, II axillary lymph nodes; or in more than three axillary lymph nodes and micrometastases or macrometastases by sentinel lymph node biopsy in clinically negative ipsilateral internal mammary lymph nodes; or in ipsilateral supraclavicular lymph nodes. G1: Low combined histologic grade (favorable); SBR score of 3-5 points. G2: Intermediate combined histologic grade (moderately favorable); SBR score: 6-7 points. G3: High combined histologic grade (unfavorable); SBR score of 8-9 points. M0: No clinical or radiographic evidence of distant metastases. Imaging studies are not required to assign the M0 category.", + "output": "Prognostic Stage IIIA Breast Cancer AJCC v8 (Prognostic Stage III Breast Cancer AJCC v8)" + }, + { + "input": "Definition: ANTITUBERCULOSIS AND ANTILEPROSY AGENTS described as a phenazine dye with anti-mycobacterial and anti-inflammatory activities. The exact mechanism through which clofazimine exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.", + "output": "Clofazimin (ANTITUBERCULOSIS AND ANTILEPROSY AGENTS)" + }, + { + "input": "Definition: Adnexal AND/OR skin appendage neoplasm described as a tumor (abnormal growth of tissue) of the ceruminal gland.", + "output": "ADENOMA, CERUMINOUS GLAND, BENIGN (Benign Neoplasm)" + }, + { + "input": "Definition: something described as scores of 3, 4 or 5", + "output": "Nottingham Grade 1 (Nottingham Grade)" + }, + { + "input": "Definition: something described as occlusal scheme in dentate patient that requires localized adjunctive therapy.", + "output": "Moderately compromised dentate occlusal scheme (Moderately compromised occlusal scheme)" + }, + { + "input": "Definition: Traumatic abnormality by mechanism described as a wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument.", + "output": "Cut (Traumatic abnormality by mechanism)" + }, + { + "input": "Definition: A [Preparations] described as a propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.", + "output": "HCl, Atomoxetine (A [Preparations])" + }, + { + "input": "Definition: Neoplastic Process described as a variant of infiltrating bladder urothelial carcinoma. It is characterized by a nested growth pattern.", + "output": "Infiltrating Bladder Urothelial Carcinoma, Nested Variant (Infiltrating Bladder Urothelial Carcinoma)" + }, + { + "input": "Definition: Neoplasms, Neuroepithelial described as it is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum.", + "output": "Dysplastic cerebellar gangliocytoma (Complex Nervous System Diseases and Syndromes)" + }, + { + "input": "Definition: Enzyme Inhibitors described as a quinolinone derivative and cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III (PDE III). Although the exact mechanism of action of is unknown, cilostazol and its metabolites appears to inhibit PDE III activity, thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. This results in an increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.", + "output": "Cilostazol (Azoles)" + }, + { + "input": "Definition: Drug allergens described as the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. As a selective serotonin reuptake inhibitor (SSRI), citalopram selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).", + "output": "citalopram (Organic Chemical)" + }, + { + "input": "Definition: ESS Questionnaire Question described as epworth Sleepiness Scale - Lying down to rest in the afternoon when circumstances permit.", + "output": "ESS - Lying Down to Rest in the Afternoon When Circumstances Permit (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family.", + "output": "FACT-HEP Version 4 - Trouble Meeting Needs of Family (Intellectual Product)" + }, + { + "input": "Definition: something described as the organophosphorus agent sulprofos.", + "output": "phosphorodithioic acid, O-ethyl O-(4-(methylthio)phenyl) S-propyl ester (Organic Chemical)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent operative intervention indicated", + "output": "Grade 4 Jejunal perforation (Jejunal Perforation, CTCAE 5)" + }, + { + "input": "Definition: something described as the organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section.", + "output": "endoplasmic reticulum cisternal network maintenance (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far.", + "output": "type II interferon binding (interferon binding)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's distress related to their family problems dealing with children.", + "output": "Distress over Family Problem of Dealing with Children (Intellectual Product)" + }, + { + "input": "Definition: something described as catalytic activity that acts to modify a tRNA.", + "output": "catalytic activity, acting on a tRNA (Molecular Function)" + }, + { + "input": "Definition: something described as in an unchanged or similar condition.", + "output": "Unchanged (Disease Qualifier)" + }, + { + "input": "Definition: Organic Chemical described as a nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.", + "output": "Hexanium (Nicotinic Antagonists)" + }, + { + "input": "Definition: Instrument - device described as a proprietary device that uses focused ultrasound to induce disruption of the blood-brain barrier.", + "output": "Exablate Neuro (Instrument - device)" + }, + { + "input": "Definition: Disease or Syndrome described as myocardial infarction associated with stent thrombosis as documented by angiography or at autopsy. (Universal definition of myocardial infarction, Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction, Eur Heart J (2007) 28 (20): 2525-2538.)", + "output": "TYPE 4B MYOCARDIAL INFARCTION (Acute Myocardial Infarction Type)" + }, + { + "input": "Definition: Pharmacologic Substance described as a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.", + "output": "GDC0084 (Pharmacologic Substance)" + }, + { + "input": "Definition: Neoplastic Process described as a low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor.", + "output": "Low Grade Lung Neuroendocrine Neoplasm (Neuroendocrine neoplasm of lung)" + }, + { + "input": "Definition: Gene Rearrangement Abnormality described as a molecular abnormality indicating rearrangement of the MLL gene. MLL gene rearrangements occur in approximately 20% of children with acute myeloid leukemia.", + "output": "Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Gene Rearrangement (Rearrangement of 11q)" + }, + { + "input": "Definition: Medical Device described as hand-finger upper-limb immobilizer orthoses designed to stabilize and provide maximum restriction of movements and/or total immobilization of the hand, fingers, and thumb by providing a static (fixed) position using a fixed splint. These orthoses typically consist of a splint that is placed encircling the distal segment of the forearm and/or wrist and attached to a semi-rigid component used to hold in an appropriate static position the hand and fingers. Immobilizer hand-finger orthoses are used mainly to protect the hand and fingers from further damage during rehabilitation after traumatic injuries.", + "output": "Orthoses, Upper Limb, Hand-Finger, Immobilizer, Splint (Orthoses, Upper Limb, Hand-Finger)" + }, + { + "input": "Definition: something described as delay in the attachment and implantation of BLASTOCYST to the uterine ENDOMETRIUM. The blastocyst remains unattached beyond the normal duration thus delaying embryonic development.", + "output": "Embryo Implantations, Delayed (Organ or Tissue Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+.", + "output": "iron-cytochrome-c reductase activity (oxidoreductase activity, acting on a heme group of donors)" + }, + { + "input": "Definition: Amino acid derivative described as a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.", + "output": "N-(3-methyl-2,6-dichlorophenyl)anthranilic acid (Organic Chemical)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum) to determine antibodies to one or more of a group of glycosphingolipids (gangliosides) that occur predominantly in the tissues of the central nervous system (e.g., GM-1, GM-2, GQ1b, GD1b gangliosides). Antiganglioside antibodies are associated with neuropathies; they may be a marker for the diagnosis of cerebral involvement in connective-tissue autoimmune diseases.", + "output": "IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antiganglioside Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic)" + }, + { + "input": "Definition: negative regulation of nucleobase-containing compound metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.", + "output": "negative regulation of pyrimidine base metabolism (regulation of pyrimidine nucleobase metabolic process)" + }, + { + "input": "Definition: Research Activity described as observational studies which include an organized system that uses observational methods to collect uniform data (clinical and other) prospectively for a population defined by a particular disorder/disease, condition (including susceptibility to a disorder), or exposure (including products, health care services, and/or procedures) and that serves a predetermined scientific, clinical, or policy purpose. Patient registries may be single purpose or on-going data collection programs that address one or more questions.", + "output": "Patient Registry Study (Observational Study)" + }, + { + "input": "Definition: Diagnostic Procedure described as primarily non-verbal tests designed to predict an individual's future learning ability or performance.", + "output": "Aptitude Tests (Educational Testing & Counseling)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.", + "output": "SKP Cullin F Box Protein Ligases (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Panic Level described as a feeling of sickness or discomfort in the stomach that may come with an urge to vomit. Nausea is a side effect of some types of cancer therapy.", + "output": "nausea symptom (Gastrointestinal tract finding)" + }, + { + "input": "Definition: something described as this gene plays a role in the remodeling and maintenance of membrane components under altered cellular conditions such as oxidative stress.", + "output": "Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) Gene (Esterase Gene)" + }, + { + "input": "Definition: something described as an ear, nose, and throat drug administration device is one of a group of ear, nose, and throat devices intended specifically to administer medicinal substances to treat ear, nose, and throat disorders. These instruments include the powder blower, dropper, ear wick, manual nebulizer pump, and nasal inhaler.", + "output": "DROPPER, ENT (Medical Device)" + }, + { + "input": "Definition: Adoptive Cell Therapy Agent described as a donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating factor; G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated with the recombinant human Fas ligand (FasL) APO010 ex vivo, and that can potentially be used for immune reconstitution purposes. The incubation of the hematopoietic stem cell graft with the apoptotic mediator Fas ligand (FasL) selectively induces apoptosis of mature T-cells which express high levels of Fas receptor, such as T stem cell memory (TSCM), T central memory (TCM), and T effector memory (TEM) cells and the pro-inflammatory T-helper cells (Th) Th1 and Th17 subsets while sparing CD34-positive stem and progenitor cells. Upon washing and further ex vivo preparations, and upon allogeneic hematopoietic stem cell transplantation (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide hematopoietic cell recovery, preserve the graft-versus-leukemia (GvL) effects, and may prevent graft-versus-host disease (GvHD).", + "output": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cell Product (Adoptive Cell Therapy Agent)" + }, + { + "input": "Definition: cytokine biosynthesis described as the chemical reactions and pathways resulting in the formation of interleukin-27.", + "output": "interleukin-27 synthesis (cytokine biosynthesis)" + }, + { + "input": "Definition: something described as stage 0a includes: Ta, N0, M0. Ta: For male penile urethra and female urethra: Non-invasive papillary carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C140458\" active clinical trials using this agent.", + "output": "stage 0a urethral cancer (Urethral Cancer by AJCC v8 Stage)" + }, + { + "input": "Definition: Higher-level cognitive functions described as mental functions of creating general ideas, qualities or characteristics out of, and distinct from, concrete realities, specific objects or actual instances.", + "output": "Abstraction (assessment of thought content)" + }, + { + "input": "Definition: Hypertrophy of salivary gland described as a chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.", + "output": "Mikulicz' disease (Lacrimal system finding)" + }, + { + "input": "Definition: something described as a question about an individual's ability to swim 25 yards nonstop.", + "output": "Swimming 25 Yards Nonstop (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cell Cycle Control described as any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "output": "negative regulation of cell cycle process (Negative Regulation of Cell Cycle)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.", + "output": "adherens junction organisation (Cell Function)" + }, + { + "input": "Definition: Oils, Volatile described as eucalyptus radiata.", + "output": "eucalyptus radiata (Eucalyptus)" + }, + { + "input": "Definition: beta-glucan metabolic process described as the chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.", + "output": "cellulose metabolic process (Molecular Function)" + }, + { + "input": "Definition: establishment of floral organ orientation described as the process that determines the orientation of petals with reference to the central axis.", + "output": "establishment of petal orientation (Organism Function)" + }, + { + "input": "Definition: Gastrointestinal and hepatobiliary procedural complications described as a disorder of the gastrointestinal tract. It is typically caused by the rapid emptying of undigested food from the stomach to the small intestine following gastroesophageal surgery but may be seen secondary to diabetes or the use of certain medications. Clinical signs may be seen 30-60 minutes after eating (early dumping): cramping, nausea, vomiting and diarrhea or they may be seen 1-3 hours later as a result of hyperinsulinemic hypoglycemia (late dumping): sweating, dizziness, confusion and heart palpitations. Untreated, the clinical course progresses to malnutrition and weight loss.", + "output": "dump syndrome (Disorder of small intestine)" + }, + { + "input": "Definition: Congenital abnormality of cardiac vein described as a developmental defect in which the coronary sinus fails to form.", + "output": "Congenital absence of coronary sinus (Coronary sinus abnormality)" + }, + { + "input": "Definition: Genetic Function described as any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes.", + "output": "regulation of isotype switching to IgA isotypes (Genetic Function)" + }, + { + "input": "Definition: Refractory Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma described as paranasal sinus squamous cell carcinoma that does not respond to treatment.", + "output": "Refractory Paranasal Sinus Squamous Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: biochemical test described as a measurement of the leptin hormone in a biological specimen.", + "output": "Leptin measurement (Chemical procedure)" + }, + { + "input": "Definition: something described as indian tobacco.", + "output": "lobelia inflata/indian tobac (Organic Chemical)" + }, + { + "input": "Definition: something described as abnormally increased variability of the size of the vertebral bodies.", + "output": "Anisospondyly (Abnormal form of the vertebral bodies)" + }, + { + "input": "Definition: FACIT-F Version 4 Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 (FACIT-F Version 4) Additional Concerns: I am too tired to eat.", + "output": "FAC07137 (FACIT-F Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Hereditary disorder of the visual system described as a rare, X-linked recessive inherited syndrome caused by mutations in the NPD gene. It is characterized by developmental retinal abnormalities that result in blindness in male infants at birth or soon after birth. Additional manifestations include progressive hearing loss and developmental motor skills delays.", + "output": "Episkopi blindness (MULTISYSTEM DISORDER)" + }, + { + "input": "Definition: something described as genes whose nucleotide sequences overlap to some degree. The overlapped sequences may involve structural or regulatory genes of eukaryotic or prokaryotic cells.", + "output": "Genes, Overlapping (Genes)" + }, + { + "input": "Definition: Pharmacologic Substance described as a measurement of the weakly bound testosterone (testosterone bound to albumin) in a biological specimen.", + "output": "TESTOSWB (Organic Chemical)" + }, + { + "input": "Definition: Hydrocarbons, Chlorinated described as an organochlorine insecticide that is slightly irritating to the skin.", + "output": "TDE (Hydrocarbons, Chlorinated)" + }, + { + "input": "Definition: sphingoid biosynthetic process described as the chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol.", + "output": "phytosphingosine synthesis (Molecular Function)" + }, + { + "input": "Definition: something described as human NAT2*7 allele is a designation for a group of variant alleles of the NAT2 gene, which is located in the vicinity of 8p22 and is approximately 10 kb in length. The wild-type allele, which encodes arylamine N-acetyltransferase 2 protein, is involved in the activation/deactivation of arylamine and hydrazine compounds. This group of allelic variants of the NAT2 gene all exhibit a SNP (c. 857G>A) that results in a G286E coding change and is associated with decreased enzymatic activity of the encoded protein.", + "output": "N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)*7 Allele (Gene or Genome)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally available small molecule and nucleoside antimetabolite with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C113444\" active clinical trials using this agent.", + "output": "cytadine analogue RX-3117 (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: DNA strand elongation involved in cell cycle DNA replication described as any DNA strand elongation that is involved in nuclear cell cycle DNA replication.", + "output": "DNA strand elongation involved in nuclear cell cycle DNA replication (DNA strand elongation involved in cell cycle DNA replication)" + }, + { + "input": "Definition: something described as a type of parallel trial design in which investigators identify pairs of subjects who are 'identical' with respect to relevant factors, then randomize them so that one receives Treatment a and the other Treatment B. See also pairing.", + "output": "matched-pair design (Clinical Trials Design)" + }, + { + "input": "Definition: Organic Chemical described as a polyhydroxylated stilbene extract from the seeds of Euphorbia lagascae, which inhibits protein tyrosine kinase Syk and induces apoptosis.", + "output": "3,3',4,5'-tetrahydroxystilbene (Organic Chemical)" + }, + { + "input": "Definition: TYPES AND MISCELLANEOUS DIURETICS described as an anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of Henle in the kidney, by binding to the Cl-binding site located in the cotransporter's transmembrane domain, thereby inhibiting reabsorption of sodium, chloride, potassium ions and water. This agent reduces plasma and extracellular fluid volume resulting in decreased blood pressure and cardiac output. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C515\" active clinical trials using this agent.", + "output": "Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)- (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as combining with anti-Mullerian hormone to initiate a change in cell activity.", + "output": "anti-Mullerian hormone receptor activity (protein-hormone receptor activity)" + }, + { + "input": "Definition: Radioconjugate described as a radioconjugate containing dabrafenib, a tyrosine kinase inhibitor of the V600 mutated version of the B-raf (BRAF) protein and labeled with the positron-emitting isotope fluorine F 18 with potential prostate tumor imaging upon positron emission tomography (PET). Upon administration, the dabrafenib moiety of fluorine F 18 dabrafenib specifically targets and binds to the BRAF V600-mutated form, expressed on tumor cells, thereby allowing the visualization of tumor cells expressing BRAF V600 upon PET. BRAF is constitutively activated in a variety of cancers due to BRAF gene mutations.", + "output": "fluorine F 18 dabrafenib (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Infected face described as an infectious process affecting a tooth.", + "output": "dental infections (Tooth Diseases)" + }, + { + "input": "Definition: meiotic cell cycle process described as the aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis.", + "output": "sexual spore wall assembly (spore wall assembly)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a component of the nuclei of stria terminalis defined on the basis of topology, connectivity and multiple stains in the rat. It is one of seven components of the posterior nuclei of stria terminalis in the Functional CNS Model - Rat ( Swanson-2004 ).", + "output": "Bed nuclei of the stria terminalis posterior division strial extension (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Protein-Serine-Threonine Kinases described as triple functional domain protein (3097 aa, ~347 kDa) is encoded by the human TRIO gene. This protein plays a role in both guanine nucleotide exchange and serine/threonine kinase activities.", + "output": "multidomain protein Trio, human (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as increase or decrease in sulfur content of the diet.", + "output": "Increase or decrease in sulfur content of the diet. (Mineral modified diet)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as a laboratory procedure that involves the study of tissues, cells, and fluids using DNA/RNA analysis techniques for the identification of characteristics and abnormalities at the molecular level.", + "output": "Molecular Analysis (Molecular Genetic Technique)" + }, + { + "input": "Definition: something described as asymptomatic or mild symptoms; additional medical intervention over baseline not indicated", + "output": "Grade 1 Eczema, CTCAE (Finding)" + }, + { + "input": "Definition: Regimen Used to Treat Pancreatic Carcinoma described as a regimen consisting of gemcitabine and irinotecan used for the treatment of pancreatic cancer.", + "output": "Gemcitabine-Irinotecan Regimen (Regimen Used to Treat Pancreatic Carcinoma)" + }, + { + "input": "Definition: something described as a chromosome band present on 22q", + "output": "22q13.2-q13.31 (Cell Component)" + }, + { + "input": "Definition: Pharmacologic Substance described as a flavonoid with a positively charged oxygen in the pyran moiety that has 5 double bonds in the benzopyran group.", + "output": "2-Phenylbenzopyrylium (Organic Chemical)" + }, + { + "input": "Definition: Cell Component described as a functional part or structural element of a chemical synapse.", + "output": "Chemical Synapse Component (Cell Component)" + }, + { + "input": "Definition: something described as stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any). For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis. N1: Metastasis in 1-2 regional lymph nodes. N2: Metastasis in 3-6 regional lymph nodes. N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.", + "output": "Stage III Esophageal Cancer AJCC v7 (Neoplastic Process)" + }, + { + "input": "Definition: something described as a pigment-producing cell located in the deeper layers of the skin.", + "output": "Chromatophores (Cells)" + }, + { + "input": "Definition: Finding described as peeling or delamination of composite materials, including coatings, that occurs when layers are separated as a result of stress or impact and resulting in loss of mechanical toughness.", + "output": "Peeled / Delaminated (Material Degradation)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence in a CDK family gene.", + "output": "CDK Gene Mutation (Gene Abnormality)" + }, + { + "input": "Definition: Glossitis described as an anomaly of the tongue characterized by loss (atrophy) of filiform papillae of the tongue, leaving areas of erythema (redness), surrounded by a serpiginous, white, hyperkeratotic border. The name geographic tongue refers to an appearance that is said to be similar to a map. []", + "output": "Geographic stomatitis (Gastrointestinal Diseases)" + }, + { + "input": "Definition: Mammal described as a monkey belonging to the species Erythrocebus patas.", + "output": "Hussar Monkey (Cercopithecidae)" + }, + { + "input": "Definition: Malformation of the nose described as slender, slit-like aperture of the nostril.", + "output": "Narrow nares (Finding)" + }, + { + "input": "Definition: Abnormal HDL3b concentration described as an elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.", + "output": "Increased HDL3b concentration (Finding)" + }, + { + "input": "Definition: VFQ25-Self Administered Format Questionnaire Question described as visual Functioning Questionnaire 25-Self Administered Format Version 2000 (VFQ25-Self Administered Format) General Vision: How would you rate your eyesight now (with glasses or contact lens on, if you wear them), on a scale of from 0 to 10, where zero means the worst possible eyesight, as bad or worse than being blind, and 10 means the best possible eyesight?", + "output": "VFQ2-Rate Your Eyesight Now (Intellectual Product)" + }, + { + "input": "Definition: something described as a Federal law establishing quality standards for all laboratory testing to ensure the accuracy, reliability and timeliness of patient test results regardless of where the test was performed and also to determine if laboratories are achieving those standards.", + "output": "CLIA (Regulation or Law)" + }, + { + "input": "Definition: positive regulation of ecdysteroid metabolic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.", + "output": "positive regulation of ecdysteroid anabolism (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as small nuclear ribonucleoprotein F (86 aa, ~10 kDa) is encoded by the human SNRPF gene. This protein is involved in pre-mRNA splicing.", + "output": "SmF (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Esthesia described as act or power of sensing with the eyes.", + "output": "Seeing functions, unspecified (VISION: GENERAL TERMS)" + }, + { + "input": "Definition: Medical Product Characteristics described as the period during which a medical product retains its properties and stated performance within specified limits if stored under defined conditions. The stability period is determined from the date the product was manufactured.", + "output": "Medical Product Stability Date (Temporal Concept)" + }, + { + "input": "Definition: something described as the delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the CYTOPLASM of the body of a NEURON and extending from one DENDRITE into another or into the AXON.", + "output": "Neurofibrils (Cell Component)" + }, + { + "input": "Definition: IL12RB1 gene described as human IL12RB1 wild-type allele is located in the vicinity of 19p13.1 and is approximately 74 kb in length. This allele, which encodes interleukin-12 receptor beta-1 chain protein, is involved in IL12 signal transduction. Heritable defects in the IL12RB1 gene are a cause of susceptibility to mycobacterial disease.", + "output": "CD212 (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as human TTF1 wild-type allele is located in the vicinity of 9q34.13 and is approximately 31 kb in length. This allele, which encodes transcription termination factor 1 protein, is involved in both transcriptional termination and replication fork arrest.", + "output": "TTF-1 (TTF1 gene)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of interleukin-11 secretion.", + "output": "positive regulation of interleukin-11 secretion (positive regulation of cytokine secretion)" + }, + { + "input": "Definition: Neoplastic Process described as an extranodal lymphoma that arises from the stomach with the bulk of the mass located in the stomach. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue.", + "output": "Gastric lymphoma (Lymphoma)" + }, + { + "input": "Definition: Pharmacologic Substance described as a cytokine produced by bone marrow stromal cells that promotes the growth of B-LYMPHOCYTE precursors and is co-mitogenic with INTERLEUKIN-2 for mature T-LYMPHOCYTE activation.", + "output": "Lymphopoietin-1 (Immunologic Factor)" + }, + { + "input": "Definition: something described as a Niger-Congo Bantu language spoken by the Nyoro people of Uganda.", + "output": "Nyoro Language (World languages)" + }, + { + "input": "Definition: Degenerative Diseases, Central Nervous System described as a rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson's syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease.", + "output": "Steele-Richardson-Olszewski Disease (Extrapyramidal Disorders)" + }, + { + "input": "Definition: BPRS 1988 Version Clinical Classification Question described as brief Psychiatric Rating Scale 1988 Version (BPRS 1988 Version) Hostility.", + "output": "BPRS01-Hostility (BPRS 1988 Version Clinical Classification Question)" + }, + { + "input": "Definition: Behavior described as a condition in which there is a derivation of pleasure from inflicting pain, discomfort or humiliation on another person or persons. The sexual significance of sadistic wishes or behavior may be conscious or unconscious.", + "output": "Sadistic behavior (Torture)" + }, + { + "input": "Definition: something described as techniques using energy such as radio frequency, infrared light, laser light, visible light, or acoustic energy to transfer information without the use of wires, over both short and long distances.", + "output": "Wireless Technologies (Telecommunications)" + }, + { + "input": "Definition: Histamine-2 Receptor Antagonist [EPC] described as a histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C374\" active clinical trials using this agent.", + "output": "CIMETIDINE (Guanidines)" + }, + { + "input": "Definition: Organ or Tissue Function described as the formation of a growth cone in an injured axon.", + "output": "formation of growth cone in injured axon (Organ or Tissue Function)" + }, + { + "input": "Definition: Stage III Pharynx Carcinoma described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis.", + "output": "Stage III Oropharyngeal Throat Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Chemical procedure described as a measurement of the hydrocodone present in a biological specimen.", + "output": "Hydrocodone Measurement (Chemical procedure)" + }, + { + "input": "Definition: Structural gene described as this gene plays a role in receptor localization.", + "output": "GRP1 (General Receptor For Phosphoinositides 1)-Associated Scaffold Protein Gene (Gene or Genome)" + }, + { + "input": "Definition: regulation of cellular localization described as any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte.", + "output": "regulation of cardiomyocyte membrane repolarization (Cell Function)" + }, + { + "input": "Definition: Finding of thumb described as localised swelling of the flexor pollicis longus muscle tendon that limits excursion within the tendon sheath and causes the tendon to be caught under the flexor tendon sheath, which typically causes a snap, pop or click when it releases with pressure.", + "output": "Nodular tendinous disease of thumb (Disorder of soft tissue of upper limb)" + }, + { + "input": "Definition: Syringes, Plunger, Protective described as plunger syringes supplied with a needle permanently attached to their tip (e.g., cemented into glass syringes, glued in plastic syringes) that are designed to provide needlestick protection (safety). These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, lessen the possibility of contact of the healthcare provider with the sharp needle. The needles are frequently fixed at a point that corresponds to the zero graduation mark.", + "output": "Syringes, Plunger, Protective, Fixed Needle (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as human HTR2C wild-type allele is located in the vicinity of Xq23 and is approximately 326 kb in length. This allele, which encodes 5-hydroxytryptamine receptor 2C protein, plays a role in serotonin binding and signaling. This gene undergoes RNA deamination at sites designated A, B, C-prime, E, C, and D; RNA editing at sites C, D and C-prime may be associated with depression.", + "output": "5-Hydroxytryptamine (Serotonin) Receptor 2C Gene (HTR2C gene)" + }, + { + "input": "Definition: something described as a chemoimmunotherapy regimen consisting of carboplatin and cetuximab that can be used for the treatment of head and neck cancer.", + "output": "carboplatin/cetuximab (Regimen Used to Treat Malignant Head and Neck Neoplasm)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective score of 7 on a scale for average pain that ranges from 0: No Pain to 10: Worst imaginable pain.", + "output": "Pain Rating Average Score 7 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Embryonic nervous system structure described as the embryonic precursor of the adenohypophysis ( Crosby-1962 ).", + "output": "Rathke's Pouch (Other Embryologic Structure)" + }, + { + "input": "Definition: Disease or Syndrome described as condition in which there is a deviation or interruption in the processing of carbohydrates in the body, its absorption, transport, storage, and utilization.", + "output": "Carbohydrate Metabolism, Inborn Error (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a subjective score of 5 on a fatigue scale that ranges from 0: No Fatigue to 10: Fatigue as bad as you can imagine.", + "output": "Fatigue Rating Score 5 (Intellectual Product)" + }, + { + "input": "Definition: Small Intestine Cancer Pathologic Regional Lymph Nodes TNM Finding v8 described as small intestine cancer with no metastasis to regional lymph nodes.", + "output": "Small Intestine Cancer pN0 TNM Finding v8 (Small Intestine Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: something described as chemical reaction in which one or more atoms replace another atom or functional group in a molecule.", + "output": "chemical substitution (Molecular Function)" + }, + { + "input": "Definition: Organic Chemical described as an orange crystalline solid compound that is metabolized to benzene in vivo. Diazoaminobenzene is used as a chemical intermediate, complexing agent and polymer additive and is a contaminant in several dyes used in drugs, cosmetics and foods. Diazoaminobenzene is genotoxic in bacteria and rodents. It is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals.", + "output": "1,3-Diphenyl-1-triazene (Organic Chemical)" + }, + { + "input": "Definition: Amphenicols [Chemical/Ingredient] described as an antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic.", + "output": "Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))- (Amphenicols [Chemical/Ingredient])" + }, + { + "input": "Definition: cellular anatomical entity described as a permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles.", + "output": "porosome (Cell Component)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in DNA synthesis. It also plays a role in the generation of antigen diversity in pre-B and pre-T lymphocytes during early differentiation.", + "output": "DNTT gene (Gene or Genome)" + }, + { + "input": "Definition: something described as an orally available, small molecule inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Merestinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95729\" active clinical trials using this agent.", + "output": "Merestinib (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Symptom aggravating factors described as applied to a sign or symptom that is worsened by smoking tobacco products. []", + "output": "Exacerbated by smoking (Finding)" + }, + { + "input": "Definition: Mytilus described as a species of mussel in the genus MYTILUS, family MYTILIDAE, class BIVALVIA, known as the common mussel. It has a bluish-black shell and is highly edible.", + "output": "Mytilus edulis (Eukaryote)" + }, + { + "input": "Definition: something described as an irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains). []", + "output": "Sickled erythrocytes (Laboratory or Test Result)" + }, + { + "input": "Definition: Bacterium described as see RTs for specific organisms.", + "output": "Bacteria, Aerobic (Bacteria)" + }, + { + "input": "Definition: Prominence described as a composite substructure of the tectum that consists of the superior colliculus and the inferior colliculus of both sides of the brainstem ( Carpenter-1983 ).", + "output": "Quadrigeminal Body (Midbrain structure)" + }, + { + "input": "Definition: Quantitative Concept described as amounts charged to the patient as payer for health care services.", + "output": "Charges and Fees (Quantitative Concept)" + }, + { + "input": "Definition: something described as a bi-functional alkylating agent, with potential antineoplastic activity. Upon administration, VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells. This agent alkylates and crosslinks DNA which ultimately leads to a reduction in cancer cell proliferation. In addition, VAL-083 does not show cross-resistance to other conventional chemotherapeutic agents and has a long half-life in the brain.", + "output": "bi-functional alkylating agent VAL-083 (Antineoplastic Agents, Alkylating)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic disease with characteristics of polyhydramnios (mostly due to placentomegaly), fetal macrosomia, abdominal wall defects, skeletal abnormalities (including bell-shaped thorax, coat-hanger appearance of the ribs and decreased mid to wide thorax diameter ratio in infancy), feeding difficulties and impaired swallowing, dysmorphic features (hairy forehead, full cheeks, protruding philtrum, micrognathia), developmental delay and intellectual disability. Additional features may include kyphoscoliosis, joint contractures, diastasis recti, and muscular hypotonia. There is increased risk of hepatoblastoma. The syndrome is an imprinting disorder involving genes within the imprinted region of chromosome 14q32.", + "output": "UNIPARENTAL DISOMY, PATERNAL, CHROMOSOME 14 (Multiple malformation syndrome with facial defects as major feature)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine.", + "output": "glycine betaine anabolism from glycine (glycine metabolic process)" + }, + { + "input": "Definition: Immunologic Factor described as a bispecific antibody fusion protein directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and the human cell surface antigen CD47, with potential immunostimulating, phagocytosis-inducing and antineoplastic activities. Upon administration of anti-PD-1/CD47 infusion protein HX009, the agent simultaneously and selectively targets and binds to PD-1 expressed on T-lymphocytes and CD47 on tumor cells. The CD47 binding by HX009 blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages, which results in macrophage activation and the specific phagocytosis of the CD47-expressing tumor cells. The binding of HX009 to PD-1 blocks the interaction between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore effector T-cell functions and may further activate cytotoxic T-lymphocyte (CTL)-mediated tumor cell killing. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA), widely expressed on normal, healthy cells, such as red blood cells and platelets, and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate. By co-targeting CD47 and PD-1, HX009 has the potential to overcome the limitations of existing CD47-targeted therapies by possibly avoiding the side effects caused by binding to CD47 on healthy hematopoietic stem cells (HSCs), which causes unwanted macrophage-mediated phagocytosis. PD-1, an inhibitory receptor belonging to the immunoglobulin superfamily (IgSF), is expressed on activated T-lymphocytes; it functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands, and plays an important role in tumor evasion from host immunity.", + "output": "HX-009 (IDO Inhibitor)" + }, + { + "input": "Definition: coal tar pitch volatiles described as a white, volatile, solid polycyclic hydrocarbon with a strong mothball odor. Naphthalene is obtained from either coal tar or petroleum distillation and is primarily used to manufacture phthalic anhydride, but is also used in moth repellents. Exposure to naphthalene is associated with hemolytic anemia, damage to the liver and neurological system, cataracts and retinal hemorrhage. Naphthalene is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing laryngeal and colorectal cancer.", + "output": "Product containing naphthalene (Medicinal product categorized by structure)" + }, + { + "input": "Definition: something described as any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.", + "output": "DNA-templated transcription, initiation (RNA chemical synthesis)" + }, + { + "input": "Definition: Carboxy-Lyases described as an enzyme group with broad specificity. The enzymes decarboxylate a range of aromatic amino acids including dihydroxyphenylalanine (DOPA DECARBOXYLASE); TRYPTOPHAN; and HYDROXYTRYPTOPHAN.", + "output": "Aromatic L Amino Acid Decarboxylases (Enzymes)" + }, + { + "input": "Definition: something described as a plant genus of the family ASTERACEAE that contains antifungal plant defensin.", + "output": "Dahlia (Coreopsideae)" + }, + { + "input": "Definition: Testicular germ cell tumor mixed described as a malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6352\" active clinical trials using this agent.", + "output": "testis cancer, embryonal carcinoma and teratoma with seminoma (Testicular germ cell tumor mixed)" + }, + { + "input": "Definition: something described as thoracic wall surgical retractors designed to temporarily separate and hold back the edges of an incision around the ribs, exposing and providing access to tissues, thoracic structures, and/or organs, with a mechanism that retains its position once set (i.e., self-retained retractors). These retractors usually include a very sturdy mechanism with blunt distal blades that are strong enough to hold back the ribs widely separated; the opening mechanism usually includes two blades that are moved along a frame that ensures that the blades remain parallel to one another as they move apart. Self-retained rib thoracic retractors (also known as rib spreaders) are provided in a variety of blade shapes and configurations.", + "output": "Rib Spreaders (Retractors, Surgical, Thoracic Wall, Rib)" + }, + { + "input": "Definition: Anterior Cranial Fossa Meningioma described as a meningioma that affects the cavernous sinus.", + "output": "meningioma of cavernous sinus (Anterior Cranial Fossa Meningioma)" + }, + { + "input": "Definition: Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.", + "output": "down-regulation of F-actin binding (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a type of microtropia with no manifest movement on cover test, the eccentric fixation point coinciding with the angle of ARC.", + "output": "Microtropia with identity (Microstrabismus)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Kidney Symptom Index-15 - I am bothered by fevers (episodes of high body temperature).", + "output": "FAC03912 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a character or string that represents a urinary system findings group.", + "output": "Urinary System Findings Group Identifier (Intellectual Product)" + }, + { + "input": "Definition: Treatment (General) described as the branch of psychology concerned with psychological methods of recognizing and treating behavior disorders.", + "output": "Psychology, Clinical (Psychology, Applied)" + }, + { + "input": "Definition: something described as asymptomatic; moderate regurgitation or stenosis by imaging", + "output": "Grade 2 Mitral Valve Disease, CTCAE (Mitral Valve Disease, CTCAE)" + }, + { + "input": "Definition: Anemia, Hemolytic, Acquired described as hemoglobin in the urine that is due to hemolysis from an external cause.", + "output": "Haemolysis Hb-uria,extern,NOS (Abnormal Hematology Test Result)" + }, + { + "input": "Definition: FOSI Questionnaire Question described as functional Assessment of Cancer Therapy-Ovarian Symptom Index (FOSI) I worry that my condition will get worse.", + "output": "FOSI - Worry My Condition Will Get Worse (FOSI Questionnaire Question)" + }, + { + "input": "Definition: Congenital anomaly of spinal cord described as the severe form of a neural tube defect where the open neural tube appears as a flattened, plate-like mass of nervous tissue with no overlying membrane.", + "output": "Myeloschisis (disorder) [Ambiguous] (Meningomyelocele)" + }, + { + "input": "Definition: Idea or Concept described as a single dimensional array.", + "output": "Vector (DataType)" + }, + { + "input": "Definition: Health Care Related Organization described as david H. Koch Institute for Integrative Cancer Research at MIT is committed to shortening the time needed for breakthrough discoveries to directly benefit cancer patients. The Institute builds on the Center's tradition of scientific excellence and promotes the development of innovative ways to diagnose, monitor, and treat cancer through advanced technology. It became an NCI-designated cancer center in 1974.", + "output": "Center for Cancer Research at the Massachusetts Institute of Technology (Health Care Related Organization)" + }, + { + "input": "Definition: Gender identity disorder described as expression of a GENDER IDENTITY inconsistent with, or not culturally-associated with the gender assigned to an individual at birth, combined with the desire to permanently transition to the gender with which they identify.", + "output": "Trans-sexualism (Organism Attribute)" + }, + { + "input": "Definition: RNA Polymerase Inhibitor described as a drug used in the treatment of infections caused by bacteria. It belongs to the family of drugs called antibiotics.", + "output": "Rifampicine (Leprostatic Agents)" + }, + { + "input": "Definition: patient care described as actions performed to support the period before, during, and immediately after the creation of an offspring/child", + "output": "rnrx perinatal care (Health Care Activity)" + }, + { + "input": "Definition: Problem Solving described as informal techniques for problem solving based on simple rules or prior experience.", + "output": "Heuristic (Problem Solving)" + }, + { + "input": "Definition: something described as terminology codelist used to identify the race of an individual within the Clinical Data Interchange Standards Consortium Study Data Tabulation Model.", + "output": "Race (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as natural fiber dressings derived from seaweed containing calcium or sodium salts of alginic acid. These dressings are usually nonadhesive; they become a hydrophilic gel when in contact with wet wounds. Alginate dressings are intended to absorb wound exudates and maintain a moist environment; they are used mainly in the wound management.", + "output": "Dressings, Nonimpregnated, Natural Fiber, Alginate (Wound and ulcer preparations)" + }, + { + "input": "Definition: nervous system disorder described as a rare neurologic disease with characteristics of persistent continuous bilateral visual experience of flickering snow-like dots throughout the visual field in association with other visual (including palinopsia, enhanced entopic phenomena, nyctalopia, photophobia and photopsia) and non-visual (migraine with or without aura, tinnitus and occasionally tremor) symptoms.", + "output": "Visual snow syndrome (Vision Disorders)" + }, + { + "input": "Definition: PDCD5 gene described as human PDCD5 wild-type allele is located in the vicinity of 19q13.11 and is approximately 6 kb in length. This allele, which encodes programmed cell death protein 5, plays a role in the regulation of apoptosis.", + "output": "Programmed Cell Death 5 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Kilovolt Peak described as peak kilovoltage output of the x-ray generator. EXAMPLE(S): 140 kv OTHER NAME(S): KVP (0018,0060) NOTE(S): The units are of electrical potential.", + "output": "CT Imaging Acquisition Protocol Element kVp (Quantitative Concept)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a type 1 neurotensin receptor.", + "output": "type 1 neurotensin receptor binding (neurotensin receptor binding)" + }, + { + "input": "Definition: Medical Device described as blood-collection tubes designed to capture small volumes of blood such as that obtained from capillary blood draws. These blood-collection tubes may consist of either a capillary tube or a small vial. Capillary tubes typically consist of small diameter glass or plastic-wrapped glass tubes that draw the blood into the tube by capillary action; filling the length of the tube end-to-end defines a specific volume (usually on the order of 10 to 200 microliters) of collected blood. Small vials typically consist of a capped low-volume plastic tube, typically with a capacity between 0.25 and 1 milliliter. Small vials intended for microsample collection may be supplied with a removable and/or integrated device to facilitate blood sample collection (e.g., capillary straw/tube, funnel). Capillary/microsample blood-collection tubes are usually available as plain tubes or with an internal coating; the type of coating (e.g., an anticoagulant such as heparin) depends on the intended use of the sample being collected, and for this reason the tubes are usually identifiable by the color of the cap. Capillary/microcollection blood-collection tubes are used to obtain samples by skin puncture from a wide range of patient populations, including infants, for serum, plasma, and whole-blood determinations..", + "output": "Capillary tube (Tubes, Blood Collection)" + }, + { + "input": "Definition: Enzyme described as von Hippel-Lindau disease tumor suppressor (213 aa, ~24 kDa) is encoded by the human VHL gene. This protein plays a role in protein ubiquitination and regulation of protein degradation.", + "output": "Elongin Binding Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Mental Retardation described as a rare X-linked intellectual disability syndrome characterised by onset in infancy of delayed motor and speech milestones, generalised tonic-clonic seizures and drop attacks and mild to moderate intellectual disability. Additional less common manifestations include scoliosis, ataxia (resulting in progressive gait disturbance) and bilateral pes planovalgus. Physical appearance is normal with no dysmorphic features reported.", + "output": "X-linked intellectual disability Hedera type (Intellectual Disability)" + }, + { + "input": "Definition: Transport Protein Gene described as this gene plays a role in cardiac muscle contraction.", + "output": "ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 Gene (Translocase Gene)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving sarcosine.", + "output": "sarcosine metabolism (Molecular Function)" + }, + { + "input": "Definition: Gastrointestinal Secretory Induction described as saliva Production Induction involves initiation of synthesis of the clear, slightly acid (pH 6.8) viscous fluid secreted from the parotid, sublingual, and submandibular salivary glands and the mucous glands of the oral cavity that contain mucins, water, organic salts, and ptylin and keep the oral mucous membrane moist, lubricate food, and partially convert starch into maltose.", + "output": "Saliva Production Induction (Physiologic Function)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 10q", + "output": "10q11.1 (Chromosome band)" + }, + { + "input": "Definition: something described as enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II.", + "output": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity (Molecular Function)" + }, + { + "input": "Definition: income maintenance described as insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage.", + "output": "disability insurance (Insurance)" + }, + { + "input": "Definition: Fetal ultrasound soft marker described as echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone.", + "output": "Hyperechogenic Bowel (Fetal ultrasound soft marker)" + }, + { + "input": "Definition: Molecular Function described as catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in).", + "output": "ATP phosphohydrolase (guanine transmembrane transporter activity)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.", + "output": "coenzyme degradation (Molecular Function)" + }, + { + "input": "Definition: Hydroxymethylglutaryl-CoA Reductase Inhibitors described as the sodium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation.", + "output": "Atorvastatin Sodium (Hydroxymethylglutaryl-CoA Reductase Inhibitors)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a lymph node located in the median or lower region of the neck.", + "output": "Median Or Lower Cervical Lymph Node (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Human immunodeficiency virus test described as the determination of the amount of antibody reaction to the HIV-1 virus and the measurement of HIV-1 p24 antigen present in a sample.", + "output": "HIV-1 Antibody + HIV-1 p24 Antigen (Human immunodeficiency virus test)" + }, + { + "input": "Definition: something described as a species of SEA URCHINS in the family Strongylocentrotidae found on the Pacific coastline from Alaska to Mexico. This species serves as a major research model for molecular developmental biology and other fields.", + "output": "Urchin, Purple Sea (Eukaryote)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine.", + "output": "-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)" + }, + { + "input": "Definition: U12-type spliceosomal complex described as a spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.", + "output": "minor precatalytic spliceosome (precatalytic spliceosome)" + }, + { + "input": "Definition: Syringomyelia described as a finding that generally has features of syringomyelia and hydromyelia.", + "output": "SYRINGOMYELIA/HYDROMYELIA (Syringomyelia)" + }, + { + "input": "Definition: Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Time Spent with Dyskinesias.", + "output": "UPD2401 (Intellectual Product)" + }, + { + "input": "Definition: Morphogenesis described as the developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed.", + "output": "leaf shaping (Organism Function)" + }, + { + "input": "Definition: High Grade Salivary Gland Carcinoma described as a salivary gland mucoepidermoid carcinoma with high grade histopathologic features. It usually follows an aggressive clinical course.", + "output": "high grade mucoepidermoid carcinoma, salivary gland (Neoplastic Process)" + }, + { + "input": "Definition: GENES: GENERAL TERMS described as the complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.", + "output": "Human Genomes (GENES: GENERAL TERMS)" + }, + { + "input": "Definition: Medical Specialities described as a speciality of medicine focused on restoring health and functional abilities after acute illness or injury.", + "output": "physical medicine (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Anatomical Abnormality described as characterized by upper and lower incisors that have emerged forward making the teeth and lips protrude.", + "output": "Bimaxillary protrusion (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.", + "output": "APP catabolic process (Molecular Function)" + }, + { + "input": "Definition: Phospholipid Metabolism described as the chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.", + "output": "geranylgeranyl diphosphate metabolic process (Molecular Function)" + }, + { + "input": "Definition: Peripheral T-Cell Lymphoma described as a peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized by systemic disease and a polymorphous infiltrate involving lymph nodes, with a prominent proliferation of high endothelial venules and follicular dendritic cells. EBV-positive cells are nearly always present. It is a clinically aggressive lymphoma and seen mainly in older adults.", + "output": "angioimmunoblastic lymphadenopathy (Immunoproliferative Disorders)" + }, + { + "input": "Definition: Protein-tyrosine kinase inhibitor described as a drug that is used to treat certain types of non-small cell lung cancer and is being studied in the treatment of other types of cancer. It is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.", + "output": "4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline (Protein kinase inhibitors, antineoplastic drugs)" + }, + { + "input": "Definition: developmental process involved in reproduction described as the developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.", + "output": "prostate gland epithelial cell development (Cell Function)" + }, + { + "input": "Definition: something described as a monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1, PCD-1; PDCD1) protein, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody AGEN2034 binds to PD-1, and thereby blocks its binding to the PD-1 ligand programmed cell death-1 ligand 1 (PD-L1), and prevents the activation of its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T cells. PD-1, a transmembrane protein in the immunoglobulin superfamily expressed on activated T cells, negatively regulates T-cell activation and effector function when activated by its ligand; it plays an important role in tumor evasion from host immunity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C136455\" active clinical trials using this agent.", + "output": "AGEN-2034 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Non-Neoplastic Stomach Disorder described as an acute or chronic infectious process affecting the stomach.", + "output": "gastric infections (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.", + "output": "culminant development (socially cooperative development)" + }, + { + "input": "Definition: Maintaining a body position described as staying in a squatting position for some time as required, such as when sitting on the floor without a seat.", + "output": "Maintaining a squatting position (Physiologic Function)" + }, + { + "input": "Definition: something described as any activity related to the care and/or treatment of cerebral edema.", + "output": "management of cerebral edema (Skull and brain therapeutic procedures)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions in the Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) gene, located in 11q13, which encodes for seipin, an amino acid protein that is an integral membrane protein of the endoplasmic reticulum. Inherited deletions are associated with Berardinelli-Seip congenital lipodystrophy type 2.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, BSCL2 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Dwarfism described as an extremely rare primary bone defect described only in a mother and her three daughters to date. The disease has characteristics of short stature, hip dislocation, minor vertebral and pelvic changes and microtia with hearing loss. There have been no further descriptions in the literature since 1981.", + "output": "COXOAURICULAR SYNDROME (Disease or Syndrome)" + }, + { + "input": "Definition: HEART: GENERAL TERMS described as the lowest superficial part of the heart which is situated behind the left 5th intercostal space.", + "output": "cardiac apex (Body Location or Region)" + }, + { + "input": "Definition: Medical Device described as devices designed to keep hot packs (also known as hydrocollator packs) warm at a consistent temperature. These devices usually consist of a stainless steel container where water is heated to a thermostatically controlled temperature (usually 165\u00b0F); hot packs are immersed in the water. Moist heat therapy pack conditioners are used to store and keep packs warm. The packs are wrapped in towels and used to provide moist heat therapy.", + "output": "Heating Units, Hot-Pack (Heating Units)" + }, + { + "input": "Definition: Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pN0 TNM Finding v8 described as one or more cytologically or histologically confirmed benign lymph nodes.", + "output": "Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pN0a TNM Finding v8 (Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pN0 TNM Finding v8)" + }, + { + "input": "Definition: Finding described as asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated", + "output": "Grade 1 Hepatitis B Reactivation, CTCAE (Finding)" + }, + { + "input": "Definition: positive regulation of protein dephosphorylation described as any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation.", + "output": "upregulation of peptidyl-serine dephosphorylation (Molecular Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the use of a low magnitude (<1 g), high frequency (30 Hz) signal to mitigate deleterious effects of estrogen deprivation on both bone health and muscle function. A low intensity vibration can be delivered synchronously to the lower extremities by a platform, transmitting the signal throughout the skeleton, recapitulating some of the mechanical stimulation experienced during exercise.", + "output": "Low Intensity Vibration Therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Empyema described as an empyema with a fistula.", + "output": "Empyema with fistula, NOS (Disorder of pleura and pleural cavity)" + }, + { + "input": "Definition: Occupational Groups described as qualified medical professionals specializing in maintaining health and providing medical care to children from birth through adolescence.", + "output": "pediatrician (Physicians)" + }, + { + "input": "Definition: chaperone-mediated protein folding described as the process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis.", + "output": "ATP-independent chaperone mediated protein folding (chaperone-mediated protein folding)" + }, + { + "input": "Definition: Document type described as a text or otherwise formatted description of the final results drawn from the investigation. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Performed Product Investigation Result Conclusion (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare disorder with manifestation of hypo or oligodontia and acanthosis nigricans. It has been described in four generations of one family. Onset generally occurs during adolescence. Some patients are born with multiple teeth. Hair anomalies (sparse body and scalp hair) also reported. Inheritance is autosomal dominant.", + "output": "ECTODERMAL DYSPLASIA WITH NATAL TEETH, TURNPENNY TYPE (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as psoriasis Area and Severity Index (PASI) Upper Extremities (U): Area score.", + "output": "PASI0119 (PASI Clinical Classification Question)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Carrying something weighing 10-20 lbs (about 4.5-9kg, like a large bag of groceries) from one room to another.", + "output": "FAC10017 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Reference Time Point described as the point in time that acts as a fixed reference point to an exposure collection.", + "output": "ECTPTREF (Reference Time Point)" + }, + { + "input": "Definition: something described as the number of doses administered for the procedure per a specific interval.", + "output": "Procedure Dosing Frequency per Interval (Quantitative Concept)" + }, + { + "input": "Definition: Cardiac and vascular procedural complications described as obstruction of flow in biological or prosthetic vascular grafts.", + "output": "Vascular Graft Restenosis (Postoperative Complications)" + }, + { + "input": "Definition: Professional Organization or Group described as a program of the New York State Department of Health that administers the activities of the Clinical Laboratory Reference System and provides the oversight of over 1,000 clinical laboratories and blood banks, including out-of-state facilities that accept clinical specimens collected in New York State. CLEP seeks to ensure the accuracy and reliability of results of laboratory tests on specimens obtained within the state through on-site inspections, review of proficiency testing performance, and evaluation of the qualifications of personnel of state permit-holding clinical laboratories and blood banks.", + "output": "Clinical Laboratory Evaluation Program (Professional Organization or Group)" + }, + { + "input": "Definition: Infectious disease of genitourinary system described as an infectious process affecting the penis.", + "output": "infections penis (Male reproductive tract infections)" + }, + { + "input": "Definition: SPTBN2 gene described as human SPTBN2 wild-type allele is located in the vicinity of 11q13.2 and is approximately 44 kb in length. This allele, which encodes spectrin beta chain, non-erythrocytic 2 protein, is involved in the regulation of actin filament function. Mutations in this gene are associated with spinocerebellar ataxia 5.", + "output": "Spectrin, Beta, Non-Erythrocytic 2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Abnormal middle phalanx morphology of the hand described as fusion of a middle phalanx of a finger with another bone.", + "output": "Symphalangism of middle phalanx of finger (Abnormal middle phalanx morphology of the hand)" + }, + { + "input": "Definition: something described as an orally available inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, ALRN-6924 binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells.", + "output": "MDM2/MDMX inhibitor ALRN-6924 (MDM2 Inhibitor)" + }, + { + "input": "Definition: Monitors & Monitoring Systems & Physiologic Monitor Modules described as monitors designed for continuous measurement and display of the body movements (i.e., physical activity) and are taken from a distant location through a point-to-point radio or other appropriate communication link (i.e., telemetric). These monitors typically consist of a main unit attached to the patient (e.g., pocket, belt, wrist) which includes electronic circuits that can process signals from movement-sensing probes (e.g., pedometers, accelerometers), and transducers. The monitor also includes a receiver that is integral or associated to the central station where the information is displayed. Physical activity monitors are used to assess patients with certain conditions (e.g., cardiac or pulmonary disorders) or healthy people (e.g., athletes) during their daily activities and/or while performing exercise. They may be also used to record sleep and wakefulness (sleep/awake cycle) during normal patient activity.", + "output": "Physical Activity Telemetric Monitors (Monitors & Monitoring Systems & Physiologic Monitor Modules)" + }, + { + "input": "Definition: something described as pathological processes of the KIDNEY or its component tissues.", + "output": "kidney disorders (Disorder of kidney and/or ureter)" + }, + { + "input": "Definition: Neuroanatomy described as peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.", + "output": "Neuron, Nociceptive (Sensory Receptor Cells)" + }, + { + "input": "Definition: Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Over the past week, have you usually had troubles handling your food and using eating utensils?", + "output": "UPD2-Eating Tasks (Intellectual Product)" + }, + { + "input": "Definition: something described as a data imputation technique that populates analysis values with the best outcome recorded within a subject.", + "output": "BOC (Statistical Imputation)" + }, + { + "input": "Definition: Neoplastic Process described as a biologic subset of breast carcinoma defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal A subtype.", + "output": "Luminal B breast cancer (Neoplastic Process)" + }, + { + "input": "Definition: Ratio described as a measurement (expressed as a fraction or percent) of the number of live female fetuses to the total number of live male and female fetuses.", + "output": "Fetal Female Sex Ratio (Ratio)" + }, + { + "input": "Definition: Intellectual Product described as a set of guidelines developed by U.S. and Canadian scientists to give information about the role of nutrients in human health. These guidelines include the Reference Daily Intakes (RDI), which are the recommended amounts of nutrients to be eaten each day to meet the needs of most healthy people. This system replaced the Recommended Dietary Allowances (RDA).", + "output": "Intakes, Dietary Reference (Guidelines)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with the mismatch repair complex MutLalpha.", + "output": "MutLalpha complex binding (Molecular Function)" + }, + { + "input": "Definition: Trachea described as hollow tree organ, the organ parts of which consists of the trachea and right and left bronchial trees. Examples: There is only one tracheobronchial tree.", + "output": "Tracheobronchial structure (Organ)" + }, + { + "input": "Definition: amino-acid betaine transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in).", + "output": "glycine betaine:hydrogen symporter activity (amino-acid betaine transmembrane transporter activity)" + }, + { + "input": "Definition: Cell Function described as the multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.", + "output": "endothelial cell proliferation (Epithelial Cell Proliferation)" + }, + { + "input": "Definition: Molecular Function described as the process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.", + "output": "extracellular sequestering of receptor ligand (extracellular negative regulation of signal transduction)" + }, + { + "input": "Definition: Finding described as a pebbly orange appearance of the fundus that is said to resemble the skin of an orange.", + "output": "Retinal peau d'orange (Finding)" + }, + { + "input": "Definition: something described as in a clinical trial, an assessment of an intervention's effects that takes the place of a patient-based conclusion.", + "output": "Markers, Surrogate (Clinical Attribute)" + }, + { + "input": "Definition: something described as improperly or abnormally shaped.", + "output": "Misshapen (General Qualifier)" + }, + { + "input": "Definition: Chromosome 2 Physical Location described as physical location of CD8B1_Gene", + "output": "2: 87000696-86954120 (Spatial Concept)" + }, + { + "input": "Definition: cytokine metabolism described as the chemical reactions and pathways involving chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.", + "output": "chemokine metabolic process (Molecular Function)" + }, + { + "input": "Definition: Physical & Psychosomatic Disorders described as a neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.", + "output": "Neoplasm benign;site unspecifi (Pathologic Processes)" + }, + { + "input": "Definition: something described as a protein encoded by the POMC gene.", + "output": "POMC Gene Product (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a synthetic heparan sulfate mimetic with potential anti-angiogenic and antineoplastic activity. Pixatimod inhibits the cleavage of heparan sulfate from cell surface proteoglycan by heparanase and thus inhibits the neovascularization induced by interaction between heparan sulfate and other extracellular matrix proteins. In this manner, this agent may have the potential to slow the progression of growth of solid tumors.", + "output": "PIXATIMOD (Pharmacologic Substance)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the extent to which an individual is or was sexually active, with or without intercourse.", + "output": "To what extent were you sexually active (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as mucosal melanoma of the head and neck in which the regional lymph nodes cannot be assessed.", + "output": "Mucosal Melanoma of the Head and Neck pNX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Organic Chemical described as an isosmotic solution containing icodextrin, a starch-derived, water-soluble glucose polymer, used in peritoneal dialysis and for the prevention of adhesion after surgery. Due to its iso-osmotic nature and inability to cross the peritoneal membrane, the icodextrin solution, upon administration into the peritoneal cavity, is able to exert osmotic pressure. This allows for the removal of excess fluids and waste products in dialysis patients. In addition, icodextrin can provide a barrier between tissue surfaces when administered during surgery. This physically separates tissues, prevents adhesion after surgery and promotes wound healing.", + "output": "Icodextrin Solution (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Children (TSCC) Wishing bad things had never happened.", + "output": "TSCC - Wishing Bad Things Never Happened (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as functions of the production of other manners of vocalization.", + "output": "Alternative vocalization functions (Organism Function)" + }, + { + "input": "Definition: something described as a phospholipid test system is a device intended to measure phospholipids in serum and plasma. Measurements of phospholipids are used in the diagnosis and treatment of disorders involving lipid (fat) metabolism.", + "output": "CHROMATOGRAPHIC, PHOSPHOLIPIDS (Medical Device)" + }, + { + "input": "Definition: Spatial Concept described as having to do with the meninges (three thin layers of tissue that cover and protect the brain and spinal cord).", + "output": "meningeal (Anatomy Qualifier)" + }, + { + "input": "Definition: something described as agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.", + "output": "antiplasmins (Fibrin Modulating Agents)" + }, + { + "input": "Definition: something described as high blood tumor burden: 1000/microL Sezary cells or more with positive clone. Note 1: for blood, Sezary cells are defined as lymphocytes with hyperconvoluted cerebriform nuclei. If Sezary cells are not able to be used to determine tumor burden for B2, then one of the following modified ISCL criteria along with a positive clonal rearrangement of the TCR may be used instead: (1) expanded CD4+ or CD3+ cells with CD4/CD8 ratio of 10 or more, (2) expanded CD4+ cells with abnormal immunophenotype including loss of CD7 or CD26. Note 2: A T-cell clone is defined by PCR or Southern blot analysis of the T-cell receptor gene.", + "output": "Mycosis Fungoides and Sezary Syndrome B2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as a term that refers to the presence of diminished numbers of cytoplasmic granules in myeloid cells.", + "output": "Hypogranularity (Conceptual Entity)" + }, + { + "input": "Definition: something described as a change in the amino acid composition of the calreticulin protein where a frameshift mutation results in the insertion of 46 non-canonic amino acids followed by a stop codon immediately after the lysine residue at position 385.", + "output": "CRP55 K385fs*47 (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Neoplastic disease described as a neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy. Such neoplasms may or may not eventually have a more aggressive clinical course. Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3646\" active clinical trials using this agent.", + "output": "Borderline Neoplasm (Neoplasms)" + }, + { + "input": "Definition: Virus described as a double-armed oncolytic adenovirus composed of a recombinant genetically modified E1/E3-deleted, adenoviral serotype 5 (Ad5) vector, with the L5 segment of the Ad5 fiber replaced by the shaft and knob from the Ad35 serotype (Ad5/35), which expresses a trimerized (TMZ) form of the membrane-bound immunostimulator CD40 ligand (CD40L; TNFSF5) and the ligand for the signaling domain 4-1BB (4-1BBL; CD137L; TNFSF9), under the control of a CMV promoter, with potential immunostimulating and antineoplastic activities. Upon intratumoral administration of double-armed TMZ-CD40L/4-1BBL oncolytic Ad5/35 adenovirus LOAd703, the virus infects and selectively replicates in tumor cells. This causes direct oncolysis and the release of a plethora of tumor-associated antigens (TAAs) from the tumor cells. The released TAAs stimulate the immune system and activate anti-tumor cytotoxic T-lymphocytes (CTLs), thereby further killing tumor cells. In addition, infected tumor cells and tumor stroma cells, including stellate cells and infiltrating immune cells, express the immunostimulants CD40L and 4-1BBL. The expressed CD40L and 4-1BBL proteins activate the CD40L- and 4-1BBL-mediated signaling pathways, respectively. This activates antigen-presenting cells (APCs), such as dendritic cells (DCs) and M1 macrophages. The DCs produce various cytokines, including interleukin-12 (IL12), IL21, tumor necrosis factor-alpha (TNFa), and interferon-gamma (IFNg), which leads to the activation and expansion of both T-cells and natural killer (NK) cells. Altogether, this modulates immune suppression in the tumor microenvironment (TME), disrupts tumor stroma, and causes additional immune stimulation against tumor cells, thereby inducing further tumor cell lysis. In addition, CD40L reduces myeloid suppressor cells in the TME. Inclusion of the chimeric Ad5/35 fiber targets CD46 and increases viral uptake in cells. Transgene expression is driven by a separate promoter to allow for efficient expression in both tumor cells and tumor stroma. Replication is restricted to tumor cells by the presence of the delta24 mutation in the E1A gene, which deletes the retinoplastoma protein (pRb)-binding domain and forces viral replication to be conditional on hyperphosphorylated pRb and a dysfunctional Rb pathway.", + "output": "Oncolytic Adenovirus LOAd703 (Oncolytic Viruses)" + }, + { + "input": "Definition: Medical Product Document described as any display of a written, printed, or graphic matter upon the immediate container of any substance or device to identify something and to indicate the nature, ownership, contents and other characteristic particulars of the object. FDA and the Supreme Court have stated that label is to be interpreted liberally, and includes not only that which accompanies an article but also that which spiritually accompanies an article as well as supplements. Drug label must include: trademark and category of product, description of product chemical and physical characteristics, clinical pharmacology, pharmacokinetics, data on absorption, distribution, metabolism and excretion, special populations, clinical studies, efficacy and safety data, indications, contraindications, adverse events warnings and precautions including lab tests; potential drug interactions, carcinogens statement, pregnancy category.", + "output": "label (Intellectual Product)" + }, + { + "input": "Definition: Physical Object described as the cellular debris and fluid produced by lysis of cells.", + "output": "Lysate (Biospecimen)" + }, + { + "input": "Definition: regulation of protein localization to cell tip described as any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip.", + "output": "regulation of protein localization to non-growing cell tip (regulation of protein localization to cell tip)" + }, + { + "input": "Definition: Exotoxins described as protein exotoxins from Staphylococcus aureus, phage type II, which cause epidermal necrolysis. They are proteins with a molecular weight of 26,000 to 32,000. They cause a condition variously called scaled skin, Lyell or Ritter syndrome, epidermal exfoliative disease, toxic epidermal necrolysis, etc.", + "output": "Exfoliatins (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable, specific inhibitor of the canonical Wnt/beta-catenin signaling pathway, with potential antineoplastic activity. Upon oral administration, CBP/beta-catenin modulator E7386 inhibits beta-catenin and prevents the interaction of beta-catenin with its transcriptional coactivator, CREB (cAMP response element-binding) binding protein (CBP). This prevents binding of beta-catenin/CBP to WRE (Wnt-responsive element), and inhibits the activation of transcription of a wide range of target genes of Wnt/beta-catenin signaling, thereby preventing gene expression of many Wnt-related, pro-survival proteins and suppressing tumor cell growth. The Wnt/beta-catenin signaling pathway regulates cell morphology, motility, and proliferation; aberrant regulation of this pathway leads to neoplastic proliferation. Beta-catenin is frequently mutated in various tumors.", + "output": "CBP/beta-catenin Modulator E7386 (Signal Transduction Inhibitor)" + }, + { + "input": "Definition: Disease or Syndrome described as endocarditis affecting a native valve of the heart.", + "output": "endocarditis native valve (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen) In the past 7 days, how much of a problem has this been for your teen: It is hard for my child to swallow food.", + "output": "PQL13-Hard to Swallow Food (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)" + }, + { + "input": "Definition: Health care facility described as facilities for psychiatric, drug, or alcohol rehabilitation patients or mentally retarded individuals who no longer need hospitalization or institutionalization, but who are not yet fully prepared to return to their communities.", + "output": "halfway house (Treatment Facilities)" + }, + { + "input": "Definition: Adenocarcinoma of anus described as a very rare tumor of the intestine, originating from the epithelium of the anal canal (including the mucosal surface, anal glands, and lining of fistulous tracts), macroscopically appearing as a nodular, often ulcerated, invasive mass located in the anal canal. Patients often present with rectal bleeding, as well as difficulty and pain during defecation. Inguinal lymphadenopathy, if present, usually indicates metastatic spread.", + "output": "Adenocarcinoma Arising in the Anal Mucosa (Neoplasm of anal canal)" + }, + { + "input": "Definition: Eukaryote described as a family of flukes (TREMATODA) characterized by a collar of spines at their anterior end. The body is elongated and is covered with spines, and the two suckers are usually close together.", + "output": "Rhopaliidae (Echinostomatoidea)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.", + "output": "Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Major Salivary Gland Cancer Pathologic TNM Finding v7)" + }, + { + "input": "Definition: something described as resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.", + "output": "Active Immunities (IMMUNE SYSTEM: GENERAL TERMS)" + }, + { + "input": "Definition: Anticoagulants described as a recombinant form of reptilase identical to or similar to the blood-coagulation factor X activator from the tropical snake Bothrops atrox. Orthologous to human thrombin, batroxobin activates soluble fibrinogen into fibrin and facilitates blood coagulation, thereby can be used in substitution of thrombin in quantitative thrombin time test. Furthermore, as a serine protease, batroxobin has the potential applications in cardiovascular treatments, such as dissolving thrombus, preventing thrombus formation and improving microcirculation.", + "output": "BATROXOBIN (Other systemic hemostatics in ATC)" + }, + { + "input": "Definition: proton-transporting two-sector ATPase complex, proton-transporting domain described as a protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.", + "output": "proton-transporting V-type ATPase, V0 domain (proton-transporting two-sector ATPase complex, proton-transporting domain)" + }, + { + "input": "Definition: something described as an ependymal tumor affecting the cerebellum and fourth ventricle and the brain.", + "output": "Cerebellar and Fourth Ventricle Ependymal Tumor (Cerebellar and Ventricular Ependymal Tumor)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation intended to be diluted in the specified liquid to obtain an emulsion for infusion.", + "output": "Concentrate for emulsion for infusion (Biomedical or Dental Material)" + }, + { + "input": "Definition: Health Care Activity described as secures the patient's clinical records and personal property. Releases belongings and valuables to the patient or designated support person.", + "output": "Implements security measures for patient records, belongings, and valuables (Behavioral Responses: Patient and Family - Knowledge/Psychosocial)" + }, + { + "input": "Definition: something described as syndrome with the association of toe syndactyly, facial dysmorphism including telecanthus and a broad nasal tip, urogenital malformations and anal atresia. Around ten cases have been reported so far. The syndrome is caused by mutations in the FAM58A gene (located on the X chromosome) encoding a protein of unknown function.", + "output": "STAR syndrome (Hereditary disorder of the visual system)" + }, + { + "input": "Definition: something described as used to describe tumor samples that exhibit well to moderately well differentiated cells. They are generally expected to be slow growing and less aggressive.", + "output": "Low Grade (Histopathologic Grade)" + }, + { + "input": "Definition: Time described as interval between successive responses.", + "output": "Interresponse Time (Time)" + }, + { + "input": "Definition: something described as documentation of investigators' medical qualifications, including but not limited to a list of publications, a list of previous studies, training certificates for specific examinations, and ICH-GCP training.", + "output": "Site Pers Supt Info (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) Did the subject usually select or ask for different programs or his/her favorite show?", + "output": "ADL0108A (Intellectual Product)" + }, + { + "input": "Definition: Cities described as city located in Massachusetts.", + "output": "City of Boston (Cities)" + }, + { + "input": "Definition: Qualitative Concept described as specifies the link between a study site and a version of the study protocol used or available for use at that site.", + "output": "StudySiteProtocolVersionRelationship (Relationships)" + }, + { + "input": "Definition: Medical Image described as an x-ray of arteries. The person receives an injection of a dye that outlines the vessels on the x-ray.", + "output": "arteriogram (Diagnostic Procedure)" + }, + { + "input": "Definition: Pulmonary Emphysema described as a condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls.", + "output": "Pulmonary emphysema, NOS (Pulmonary Emphysema)" + }, + { + "input": "Definition: FIBROSES AND TISSUE REPAIR described as an enlargement of the tips of the fingers or toes and a change in the angle where the nails emerge. It occurs when the amount of soft tissue beneath the nail beds increases. It may be idiopathic, hereditary, or associated with a wide range of diseases, including cardiopulmonary disorders and malignant neoplasms.", + "output": "Digital Clubbing (Fibrosis AND/OR repair abnormality)" + }, + { + "input": "Definition: Injury of body structure described as trauma to the ear.", + "output": "ear injury (Injury of unspecified body region)" + }, + { + "input": "Definition: Physical shape described as generic term for any circumscribed mass of foreign (for example, lead or viruses) or metabolically inactive materials (for example, ceroid or Mallory bodies), within the cytoplasm or nucleus of a cell; inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells.", + "output": "Inclusion Body (cellular anatomical entity)" + }, + { + "input": "Definition: Subcutaneous panniculitis-like T-cell lymphoma described as the reemergence of subcutaneous panniculitis-like T-cell lymphoma after a period of remission.", + "output": "Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma (Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to drink from a glass.", + "output": "Drinking from a glass (Intellectual Product)" + }, + { + "input": "Definition: Recombinant Fowlpox-TRICOM Vaccine described as a cancer vaccine comprised of a recombinant fowlpox virus vector encoding the carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM). This agent may enhance CEA presentation to antigen presenting cells (APC) and activate cytotoxic T-cells against CEA-expressing tumors.", + "output": "Recombinant Fowlpox-CEA(6D)/TRICOM Vaccine (Recombinant Fowlpox-TRICOM Vaccine)" + }, + { + "input": "Definition: TRANSCRIPTION FACTOR described as DNA-binding protein Ikaros (519 aa, ~58 kDa) is encoded by the human IKZF1 gene. This protein is a transcriptional enhancer that is involved in B- and T-cell maturation.", + "output": "IKZF1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as pyramidal skinfold extending from the base to the top of the nails is a rare and distinctive anomaly seen in popliteal pterygia syndrome.", + "output": "Pyramidal skinfold extending from the base to the top of the nails (Nail abnormality)" + }, + { + "input": "Definition: something described as squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.", + "output": "Advanced Squamous Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Environment, Controlled described as systems that provide all or most of the items necessary for maintaining life and health. Provisions are made for the supplying of oxygen, food, water, temperature and pressure control, disposition of carbon dioxide and body waste. The milieu may be a spacecraft, a submarine, or the surface of the moon. In medical care, usually under hospital conditions, LIFE SUPPORT CARE is available.", + "output": "Life Support System (Environment, Controlled)" + }, + { + "input": "Definition: Abnormal behavior described as persistent repetition of a response to different and perhaps inappropriate stimuli which may be due to a refusal or an inability to interrupt one's behavior or to change from one task to another. Also, pathological repetition of thoughts, acts, or verbalizations.", + "output": "Perseverations (Conceptual Entity)" + }, + { + "input": "Definition: something described as a tool designed to assign allogeneic hematopoietic cell transplantation patients into one of four overall survival (OS) risk groups based on disease type and disease status at the time of transplantation. This index applies regardless of age, conditioning regimen, donor type, and graft source.", + "output": "DRI (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Organic Chemical described as an orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99380\" active clinical trials using this agent.", + "output": "AZD1208 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a count of the CD1 expressing cells per unit of a biological specimen.", + "output": "CD1 Expressing Cell Measurement (Cell Count)" + }, + { + "input": "Definition: DRUGS FOR PARASITES: GENERAL TERMS described as drug or agent used to treat or prevent parasitic infections.", + "output": "Antiparasitic Drugs (DRUGS FOR PARASITES: GENERAL TERMS)" + }, + { + "input": "Definition: Body Site Modifier described as pertaining to the back or upper surface of the body; opposite of ventral.", + "output": "Dorsal (Spatial Concept)" + }, + { + "input": "Definition: Intellectual Product described as the PTSD Checklist for DSM-5 - In the past month, how much were you bothered by: Loss of interest in activities that you used to enjoy?", + "output": "PCL-5 - Loss of Interest in Activities (Intellectual Product)" + }, + { + "input": "Definition: something described as allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.", + "output": "FOOD ALLERGY TO MILK (Pathologic Function)" + }, + { + "input": "Definition: Osteomas and Osteosarcomas described as a form of osteogenic sarcoma of relatively low malignancy, probably arising from the periosteum and initially involving cortical bone and adjacent connective tissue. It occurs in middle-aged as well as young adults and most commonly affects the lower part of the femoral shaft.", + "output": "Juxtacortical Osteogenic Sarcoma (malignant bone-forming neoplasm of bone)" + }, + { + "input": "Definition: something described as x-ray film dryers designed to remove moisture using an automated heated unit from an x-ray film after it has been developed, fixed, and washed. These dryers typically consist of a unit with an internal drum in which the films are rolled, an electrical heating source, and temperature and speed controls. Automated film dryers are frequently included as an integral part of x-ray film processors that perform all x-ray film processing functions (i.e., developing, fixing, washing, and drying).", + "output": "Dryers, X-Ray Film, Automated (X-ray film dryer)" + }, + { + "input": "Definition: negative regulation of dopamine receptor signaling pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway.", + "output": "down regulation of phospholipase C-activating dopamine receptor signaling pathway (negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)" + }, + { + "input": "Definition: something described as a benign or malignant neoplasm that affects the vertebrae, vertebral canal, and/or spinal cord.", + "output": "Spinal Neoplasm (Bone neoplasms)" + }, + { + "input": "Definition: Pharmacologic Substance described as the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.", + "output": "Amlodipine maleate (Pharmacologic Substance)" + }, + { + "input": "Definition: Spatial Concept described as the diameter of the region from which data is used in creating the reconstruction of the image. EXAMPLE(S): OTHER NAME(S): Reconstruction Diameter (0018,1100) NOTE(S): The units are of linear distance, e.g. mm.", + "output": "ImagingReconstructionProtocolElement.reconstructionDiameter (Spatial Concept)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.", + "output": "regulation of synaptic structural plasticity (regulation of synapse organization)" + }, + { + "input": "Definition: Pathologic Function described as an immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.", + "output": "natural killer cell mediated immune response to tumor cell (Pathologic Function)" + }, + { + "input": "Definition: something described as a cortical area in the postcentral gyrus defined on the basis of cytoarchitecture in the rhesus macaque (Macaca mulatta). The author regarded it as the same as area 2 of Brodmann (guenon). The cortical thickness was 1.24 mm. The molecular layer of the cerebral cortex (I) was narrower than in area 5 of Peele and area 7 of Peele and contained more cells. The external granular layer (II) was about 9 cells deep with granule cells larger than in layer IV; an occasional small pyramidal cell was seen;and the boundary with layer III was indistinct. Cells in the external pyramidal layer (III) were densely distributed pyramidal cells, many triangular in shape, arranged in three sublayers with smaller cells in the outer sublayers and many large cells deeper. The internal granular layer (IV) was composed predominantly of very small granule cells and was about 12 cells deep. The internal pyramidal layer (V) was ill-defined and contained pyramidal cells ranging from small in the outer portion to a few large cells deeper. The multiform layer (VI) was more densely populated than in area 1 of Peele; it contained small pyramidal cells and fusiform cells, many with processes parallel to the cortical surface ( Peele-1942 ).", + "output": "area 2 of Peele-1942 (Body Location or Region)" + }, + { + "input": "Definition: Adenosine Diphosphate Sugars described as an ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.", + "output": "5'-Diphosphoribose, Adenosine (Biologically Active Substance)" + }, + { + "input": "Definition: Nitrogen and nitrogen compound described as a local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.", + "output": "N-(2-Methylphenyl)-2-(propylamino)propanamide (Anilides)" + }, + { + "input": "Definition: solid substance described as a solid formed by the solidification of a chemical and having a highly regular atomic structure.", + "output": "crystal (Urinalysis)" + }, + { + "input": "Definition: Isomerase Gene described as this gene is involved in immunoregulation.", + "output": "FK506 binding protein 8, 38kDa (Isomerase Gene)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).", + "output": "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Neoplastic Process described as cancer that has spread from the breast to the skin.", + "output": "cutaneous breast cancer (Carcinoma Metastatic to the Skin)" + }, + { + "input": "Definition: Neoplastic Process described as a myelodysplastic syndrome characterized by the presence of at least 10% dysplastic neutrophils in the bone marrow or the peripheral blood.", + "output": "Refractory Neutropenia (Neutropenia)" + }, + { + "input": "Definition: Health Care Related Organization described as health planning and resources development agencies which function in each health service area of the United States (PL 93-641).", + "output": "health system agency (Health Care Related Organization)" + }, + { + "input": "Definition: neuron component described as the portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.", + "output": "neuronal cell body (Cell Component)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as actions performed to restore physical functioning", + "output": "Musculosketal Care (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. In addition, AZD6738 sensitizes tumor cells to chemo- and radiotherapy. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C111993\" active clinical trials using this agent.", + "output": "ATR KINASE INHIBITOR AZD6738 (Organic Chemical)" + }, + { + "input": "Definition: Rare Non-Neoplastic Disorder described as a spectrum of anomalies without common etiology that occurs during development of the abdominal wall. Clinical features may include omphalocele, exstrophy of the bladder and rectum, imperforate anus, and spinal defects. Genital and reproductive anomalies may include bifid penis, clitoris, and/or uterus.", + "output": "Omphalocele exstrophy imperforate anus (Disease or Syndrome)" + }, + { + "input": "Definition: Orbital region described as space of compartment of head, each instance of which is bound by the internal surface of wall of some orbit.", + "output": "Orbital compartment (Body cavities)" + }, + { + "input": "Definition: something described as a wild-type zebrafish line that has long-fins and spots (Tupfel). This line was established from the rearing of mixed eggs of well-laying females.", + "output": "Tupfel Long Fin - zebrafish (Zebrafish)" + }, + { + "input": "Definition: something described as an antibiotic, or its derivative, that can kill or inhibit the growth of tumor cells. Antineoplastic antibiotics can interfere with the normal function of cellular nucleic acids and proteins.", + "output": "ANTINEOPLASTIC ANTIBIOTICS (Antibiotic)" + }, + { + "input": "Definition: something described as a localized group of cells that exhibit some type of cytologic alteration resulting in basophilia.", + "output": "Basophilic Focus (Finding)" + }, + { + "input": "Definition: Intellectual Product described as hamilton Depression Rating Scale 17 Item (HAMD-17) Anxiety psychic.", + "output": "HAMD1-Anxiety Psychic (HAMD-17 Questionnaire Question)" + }, + { + "input": "Definition: Dietary Supplements described as an herbal supplement containing an extract from guarana (Paullinia cupana), a climbing plant of the Sapindaceae family which is native to the Amazon basin, with stimulant, antioxidant and potential chemoprotective activities. Guarana supplement contains various phytochemicals, including caffeine, theobromine, theophylline, tannins, saponins, catechins, epicatechins, proanthocyanidols and other compounds in minor concentrations. Caffeine is a central nervous system stimulant and may reduce chemotherapy-related fatigue. Tannins and other polyphenols may have chemopreventive activity. Intake of the guarana supplement may prevent cancer-related anorexia. In addition, animal studies have demonstrated that the ingestion of guarana resulted in decreased proliferation and increased apoptosis of tumor cells.", + "output": "Paullinia cupana supplement (Dietary Supplements)" + }, + { + "input": "Definition: something described as a composite substructure of the ventral nuclear group of the thalamus based on connectivity and function. It includes the ventral anterior nucleus, the ventral lateral nucleus and the oral part of the ventral posterolateral nucleus. It consists of three regions: the anterolateral region of the motor thalamus, the anteromedial region of the motor thalamus and the posterior region of the motor thalamus ( Macchi-1997 ). The nomenclature of this region is extremely confusing, partly because of the number of anatomists who have independently segmented and named substructures according to different criteria and partly because reports from clinical studies in humans and neurophysiological studies in macaques use quite different nomenclatures. See Macchi-1997 and Krack-2002 for comprehensive treatment of these issues", + "output": "motor thalamus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Metabolism described as the sum of all chemical changes that take place in a cell through which energy and basic components are provided for essential processes, including the synthesis of new molecules and the breakdown and removal of others.", + "output": "Metabolic Process, Cellular (cellular process)" + }, + { + "input": "Definition: Disease or Syndrome described as pituitary abnormality that causes abnormally fast growth in infancy or early childhood. Individuals may present with hyperplasia of the pituitary gland or a benign pituitary adenoma. Rarely both pituitary hyperplasia and an adenoma may be present. The abnormal pituitary gland releases excess amounts of growth hormone and in some cases excess amounts of growth hormone releasing hormone. Additional manifestations of the disorder include coarse facial features, acral enlargement, an increased appetite and acanthosis nigricans. Caused by duplication on the X chromosome, the duplication, often referred to as an Xq26.3 microduplication, occurs on the long (q) arm of the chromosome at a location designated q26.3. The disease follows an X-linked dominant inheritance pattern. In females, the condition results from de novo duplications involving the GPR101 gene. In males, the condition often results from somatic mosaicism. Other affected males inherit the duplication from their affected mother.", + "output": "CHROMOSOME Xq26 MICRODUPLICATION SYNDROME (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Being so absent-minded that he or she didn't notice what was going on around him or her.", + "output": "TSCYC185 (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: Organism Function described as any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.", + "output": "down-regulation of neurological process (regulation of nervous system process)" + }, + { + "input": "Definition: Homeopathic remedies letter H described as muriate of hydrastia.", + "output": "hydrastinum muriaticum/muria (Organic Chemical)" + }, + { + "input": "Definition: positive regulation of blood coagulation described as any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.", + "output": "activation of blood coagulation via clotting cascade (positive regulation of blood coagulation)" + }, + { + "input": "Definition: Immunotoxins described as an immunoconjugate consisting of a human monoclonal antibody directed against the deletion-mutant of epidermal growth factor receptor, EGFRvIII, conjugated via a non-cleavable linker to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity. The monoclonal antibody moiety of this immunoconjugate binds to EGFRvIII on tumor cell surfaces. After internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that express the EGFRvIII mutant. EGFRvIII, a deletion mutation of exons 2-7 in the epidermal growth factor receptor gene, is overexpressed by a variety of cancers, including glioblastoma multiforme, non-small lung carcinoma, and breast carcinoma.", + "output": "Anti-EGFRvIII-DM1 Immunoconjugate AMG 595 (Immunotoxins)" + }, + { + "input": "Definition: disease/disorder prevention/control described as branch of dentistry concerned with the prevention of disease and the maintenance and promotion of oral health.", + "output": "preventive dentistry (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Biologic Function described as any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere.", + "output": "maintenance of protein location in membrane (maintenance of protein location in cell)" + }, + { + "input": "Definition: Pharmacologic Substance described as selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin; acts pharmacologically to deplete endogenous levels of serotonin.", + "output": "para Chlorophenylalanine (Serotonin Antagonists)" + }, + { + "input": "Definition: Secondary malignant neoplasm of other specified sites described as the spread of a malignant neoplasm to the kidney. This may be from a primary kidney malignant neoplasm involving the opposite kidney, or from a malignant neoplasm at a distant site.", + "output": "Metastatic malignant neoplasm to kidney, NOS (Secondary Neoplasm)" + }, + { + "input": "Definition: Operating Tabletops described as detachable tabletops designed for use as a component of surgical tables that may be configured for several different procedures. These tabletops typically consist of a rectangular top made of metal, plastic, or a metal/plastic/carbon-fiber composite that is supported by a fixed pedestal (e.g., central column, lateral supports) that may be mounted on a movable, swivel-caster base. The tabletop can also be transferred to trolleys to transport patients to and from the operating room. Multi-specialty tabletops and their individual segments are raised and lowered by mechanical gears or hydraulic piston systems using manual controls (e.g., cranks, foot pedals) or electronic controls (e.g., foot pedals, levers, remote-control units). Some multi-specialty operating tabletops can be configured for a variety of surgical specialties (e.g., general surgery, gynecology/urology, ophthalmology/ ear, nose, and/or throat [ENT], orthopedic, neurosurgery, vascular surgery) frequently by adding detachable accessories. The tabletops are available both in adult and pediatric sizes.", + "output": "Operating Tabletops, Multi-Specialty (Medical Device)" + }, + { + "input": "Definition: something described as the creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.", + "output": "negative chemotaxis involved in interneuron migration from the subpallium to the cortex (Cell Function)" + }, + { + "input": "Definition: something described as counseling services provided by counselors or teacher counselors in order to help school, college, or university students cope with adjustment problems. Compare EDUCATIONAL COUNSELING.", + "output": "school counseling (Educational Testing & Counseling)" + }, + { + "input": "Definition: Mitochondrial matrix described as a ribonucleotide sequence that is encoded for by mitochondrial DNA.", + "output": "RNA, Mitochondrial (RNA, Untranslated)" + }, + { + "input": "Definition: something described as a protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.", + "output": "FANCM-MHF complex (Cell Component)" + }, + { + "input": "Definition: something described as a question about the frequency of an individual's heartburn during the past seven days.", + "output": "In the last 7 days, how often did you have heartburn (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Physical shape described as the condition of being irregular or not conforming to type.", + "output": "atypia morphology (Finding)" + }, + { + "input": "Definition: something described as a technique for counting, examining and sorting microscopic particles suspended in a stream of fluid.", + "output": "Flow Cytofluorometries (Laboratory Procedure)" + }, + { + "input": "Definition: Hematology procedure described as an index of the variation in the size of the red cells and can be used to detect subtle degress of anisocytosis. It is computed directly from the RBC histogram and is calculated as a standard statictical value, the coefficient of variation of the red cell volume ditribution (ratio of standard deviation and mean copuscular volume).", + "output": "red cell width distribution (Hematology procedure)" + }, + { + "input": "Definition: Mollusca described as very diverse group includes octopus, squid, nautilus, and cuttlefish; a shell is sometimes present, and if present, it is divided into chambers; and the animal occupies the last-formed chamber with a filament of tissue extending to the oldest chamber; Cephalopods have the most complex brain of any invertebrate; most species also have excellent eyes that are astonishingly similar to those of vertebrates; most species have a single pair of gills, a mostly closed circulatory system, and accessory or branchial hearts.", + "output": "Cephalopods (Eukaryote)" + }, + { + "input": "Definition: CCNB1 gene described as human CCNB1 wild-type allele is located within 5q12 and is approximately 11 kb in length. This allele, which encodes G2/mitotic-specific cyclin-B1 protein, is involved in mitotic regulation during the G2/M transition of the cell cycle.", + "output": "CGB1 (Gene or Genome)" + }, + { + "input": "Definition: Prenatal care described as any elsewhere undefined prenatal service, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "Undefined prenatal service narrative required (Prenatal care)" + }, + { + "input": "Definition: Social Role described as behavioral patterns expected from individuals by their social group believed to be typical of their sex; certain behavior patterns are culturally influenced, such as ascendance submissiveness, or occupational choices; sex role is often called psychosexual role.", + "output": "Roles, Sex (Social Behavior)" + }, + { + "input": "Definition: transferase activity, transferring alkyl or aryl (other than methyl) groups described as catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+).", + "output": "sym-norspermidine synthase activity (Molecular Function)" + }, + { + "input": "Definition: ACC-AHA Measure described as the treatment the patient had for congenital heart disease.", + "output": "Intervention for Congenital Heart Disease (Health Care Activity)" + }, + { + "input": "Definition: Clinical Drug described as perque(TM) Choline Citrate each 7.86 oz. UPC Code 791760014108.", + "output": "Perque (TM) Choline Citrate each 7.86 oz (Clinical Drug)" + }, + { + "input": "Definition: Intellectual Product described as a method for quantitating peptides in label-free samples subjected to liquid chromatography-mass spectrometry (LC/MS).", + "output": "Label-Free Peptide Level Quantification (LC/MS Label-Free Quantification)" + }, + { + "input": "Definition: Cell Communication described as the phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.", + "output": "cell aggregation (cellular process)" + }, + { + "input": "Definition: glucosyltransferase activity described as catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside.", + "output": "flavonol-3-O-glycoside glucosyltransferase activity (glucosyltransferase activity)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Voxtalisib inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.", + "output": "voxtalisib (Phosphatidylinositide 3-Kinase Inhibitor)" + }, + { + "input": "Definition: Irrigation Solutions described as a crystalloid solution that contains SODIUM CHLORIDE; SODIUM LACTATE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. It is used for FLUID THERAPY.", + "output": "Lactated Ringers Solution (Electrolyte Replenishers and Foods)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).", + "output": "Receptors, Purinergic P1 (Purinoceptor)" + }, + { + "input": "Definition: C [Preparations] described as the anhydrous form of calcifediol, a hormone precursor that is produced by the hydroxylation of vitamin D in the liver. Calcifediol can be further hydroxylated in the kidney to give calcitriol, the active form of vitamin D. Plasma levels of this compound are measured to determine the vitamin D status of patients.", + "output": "calcifediol anhydrous (Vitamin D Analog)" + }, + { + "input": "Definition: Electrocardiogram abnormal described as an electrocardiographic finding of a T wave which appears peaked, inverted, flattened or biphasic.", + "output": "T Wave Abnormality by EKG Finding (Finding)" + }, + { + "input": "Definition: Medical, dental, veterinary AND/OR related worker described as a provider qualified by a Doctor of Chiropractic (D.C.), licensed by the State and who practices chiropractic medicine -that discipline within the healing arts which deals with the nervous system and its relationship to the spinal column and its interrelationship with other body systems.", + "output": "chiropractors (Professional or Occupational Group)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the volume dispersion within a reticulocyte population, calculated as the standard deviation of the mean reticulocyte volume divided by the mean reticulocyte volume, multiplied by 100 for conversion to a percentage.", + "output": "Ret RDW Coefficient of Variation (Reticulocyte Distribution Width)" + }, + { + "input": "Definition: Cell Function described as any process that maintains the redox environment of a cell or compartment within a cell.", + "output": "cell redox homeostasis (regulation of cellular process)" + }, + { + "input": "Definition: Virus described as a gammaretrovirus that has been isolated from human biological samples and associated with familial and sporadic prostate cancer and chronic fatigue syndrome.", + "output": "Viruses, XMRV (Gammaretrovirus)" + }, + { + "input": "Definition: Translation Process Protein described as selenocysteine-specific elongation factor (596 aa, ~65 kDa) is encoded by the human EEFSEC gene. This protein plays a role in the synthesis of selenocysteine-containing proteins.", + "output": "Selenocysteine-Specific Elongation Factor (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a question about whether an individual feels or felt that their love relationships are full and complete.", + "output": "Did You Feel That Your Love Relationships Were Full and Complete (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cell Component described as the residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior.", + "output": "Nuclear Scaffold (Cell Component)" + }, + { + "input": "Definition: Remote location new client without ICD diagnosis described as using Oriental diagnostic methods in a simple, 10-minute, in-office meeting to assess the health status of a new Oriental medicine client and develop an Oriental medicine treatment plan. Use for client/patient assessment and/or history.", + "output": "Simple new 10 minutes out-of-office Oriental medicine intake (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Molecular Function described as a G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.", + "output": "proteinase activated receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as a quantity of time that should elapse between when an activity is ready for execution and the actual beginning of the execution.", + "output": "DefinedContingentOnRelationship.pauseQuantity (Pause Quantity)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as patient Determined Disease Steps test code.", + "output": "CDISC Questionnaire PDDS Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: Body Location or Region described as a transitional zone between the piriform area and the the cortical amygdalar nucleus identified as a separate structure by some anatomists in the human ( Mai-1997 ), the rat ( Paxinos-2009b )and the mouse ( Franklin-2008; Hof-2000 ).", + "output": "amygdalocortical (corticoamygdaloid) transition area (Body Location or Region)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an aspartate amino transferase (AST/SGOT) test system is a device intended to measure the activity of the enzyme aspartate amino transferase (AST) (also known as a serum glutamic oxaloacetic transferase or SGOT) in serum and plasma. Aspartate amino transferase measurements are used in the diagnosis and treatment of certain types of liver and heart disease.", + "output": "HYDRAZONE COLORIMETRY, AST/SGOT (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Intestinal ulcers and perforation NEC described as an erosion of the mucous membrane in a portion of the ileum.", + "output": "ULCER ILEUM (SMALL/LARGE BOWEL)" + }, + { + "input": "Definition: fatty acid binding described as interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.", + "output": "long-chain fatty acid binding (Molecular Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a transferrin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the transferrin (an iron-binding and transporting serum protein) in serum, plasma, and other body fluids. Measurement of transferrin levels aids in the diagnosis of malnutrition, acute inflammation, infection, and red blood cell disorders, such as iron deficiency anemia.", + "output": "TRANSFERRIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Procedure on spinal cord described as x-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.", + "output": "myelogram (Medical Image)" + }, + { + "input": "Definition: something described as the percentage of the dose that is recovered from the specimen type, from dosing to end of the current collection interval divided by the weight.", + "output": "Percent Recovered Normalized by Weight (Percent Recovered)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Lymphoma Version 4 - Functional Well-Being: I am content with the quality of my life right now.", + "output": "FACT-LYM Version 4 - Content With Quality of My Life (Intellectual Product)" + }, + { + "input": "Definition: something described as a coded value specifying the kind of product. EXAMPLE(S): veterinary medicine, diagnostic device, tissue, fluid, cell, molecule, protein, clot tube, KEDTA, ACD, sterile specimen cup, data analysis software, instrument controlling software OTHER NAME(S): NOTE(S): All members of a type share similar functions and general characteristics, especially the purpose for which they are used.", + "output": "Product Type Code (Type Code)" + }, + { + "input": "Definition: Unit of Dose Calculation described as a dose calculation unit equal to mass concentration of a substance expressed in kilograms per unit volume of the mixture equal to one cubic meter per time period of one minute.", + "output": "Milligram per Milliliter per Minute (Unit of Dose Calculation)" + }, + { + "input": "Definition: Anti-Infective Agents described as an injectable formulation composed of opebacan, a 21 kDa recombinant fragment of human bactericidal/permeability-increasing protein (BPI), with potential anti-infective activity. Upon intravenous administration, opebacan is able to mimic BPI and binds to and neutralizes lipopolysaccharides (LPS or endotoxins), which are components of the cell wall of gram-negative bacteria that induce a potent innate immune response. This may prevent an endotoxin-mediated inflammatory response and may prevent graft-versus-host-disease (GvHD) after myeloablative allogeneic hematopoietic stem cell transplantation (aHSCT). BPI, a host-defense protein against microbial infection, is naturally produced by neutrophils. Chemo- and radio-therapy induce neutropenia and depletion of endogenous BPI. These therapies also cause intestinal damage and release of bacterial endotoxins into the bloodstream, which initiate a systemic inflammatory response, activate donor T-lymphocytes and possibly cause GvHD following aHSCT.", + "output": "Opebacan (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as psoriasis Area and Severity Index (PASI) Lower Extremities (L): Infiltration (I).", + "output": "PASI - Lower Extremities (L): Infiltration (Intellectual Product)" + }, + { + "input": "Definition: NICHD Terminology described as terminology developed by a collaborative effort of the National Cancer Institute's Enterprise Vocabulary Services, the National Institute of Child Health and Human Development, and an international group of clinicians and informaticists to support the reporting of events in the pediatric population that are related to endocrine disorders.", + "output": "Pediatric Endocrine Terminology (NICHD Terminology)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Lifting something weighing more than 20 lbs (about 9 kg, like a medium-sized suitcase).", + "output": "FAC100-Limit: Lifting More Than 20 Lbs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Ascites, CTCAE described as symptomatic; medical intervention indicated", + "output": "Grade 2 Ascites (Ascites, CTCAE)" + }, + { + "input": "Definition: Cell Function described as a G1 phase checkpoint in SACCHAROMYCES.", + "output": "START Cell Cycle Checkpoint (Cell Function)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 2q", + "output": "2q11.2-q12 (Chromosome band)" + }, + { + "input": "Definition: something described as a subjective rating score of 4 on a linear analogue scale with anchor point descriptions of 0: As bad as it can be and 10: As good as it can be.", + "output": "Quality of Life Rating Score 4 (Finding)" + }, + { + "input": "Definition: Arteritis described as an acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.", + "output": "Kawasaki Syndrome (Acute skin disorder)" + }, + { + "input": "Definition: Intellectual Product described as works about substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.", + "output": "Dissertations, Academic as Topic (Publications)" + }, + { + "input": "Definition: Mammal described as a confident, calm, and powerful farm and estate watch dog. Their coat is medium length, thick, straight, and dense; colors can be black, grey, or fawn, with or without brindling. The average height range is 25-29 inches and the average weight range is 77-132 pounds.", + "output": "Rafeiro do Alentejo (Working Breed)" + }, + { + "input": "Definition: Pneumonitis described as chronic inflammation and progressive fibrosis of the pulmonary alveolar walls with steady progressive dyspnea; finally, resulting in death from lack of oxygen or right heart failure.", + "output": "FIBROSING ALVEOLITIS, CRYPTOGENIC (Pulmonary Fibrosis)" + }, + { + "input": "Definition: negative regulation of innate immune response described as any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.", + "output": "down-regulation of complement activation, lectin pathway (Negative Regulation of Complement Activation)" + }, + { + "input": "Definition: Disturbance in thinking described as belief that one's utterances, thoughts, or behavior can have a controlling influence on specific events or prevent their occurrence by means that operate beyond the normal laws of cause and effect.", + "output": "Magical thinking (Disorder of form of thought)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123830\" active clinical trials using this agent.", + "output": "Porcupine Inhibitor ETC-1922159 (Enzyme Inhibitor Drugs)" + }, + { + "input": "Definition: Primary Indicator described as specifies whether this is the main or principal document identifier.", + "output": "Document Identifier Primary Indicator (Qualitative Concept)" + }, + { + "input": "Definition: Gram-Negative Bacterial Infections described as series of infections caused by Borrelia spp.; characterized by a fever lasting 4 days and then suddenly ending; relapses become progressively milder.", + "output": "Borrelia infection NOS (Gram-Negative Bacterial Infections)" + }, + { + "input": "Definition: something described as blessed thistle.", + "output": "Carduus benedictus / blessed thistle (Organic Chemical)" + }, + { + "input": "Definition: Manufactured Object described as keypads designed to control access to cabinets and/or rooms. These devices typically consist of a sturdy, mechanical and/or electromechanical wall- or door-mounted grid of keys arranged for efficient entry of data (alphabetic, numeric, alphanumeric, symbol), that are pressed by the user; the keypads are usually coupled to locking mechanisms. Keypads intended to permit access to rooms (e.g., through electric-controlled doors) and/or other enclosures (e.g., cabinets) have a different entry code for each user; they are frequently part of identification and security and/or automation (e.g., pharmacy, laboratory, radiology) systems.", + "output": "Keypads, Access Control (Keypads)" + }, + { + "input": "Definition: Food described as drinkable liquids containing ETHANOL.", + "output": "alcoholic beverages (ALCOHOLIC BEVERAGES AND TOBACCO PRODUCTS)" + }, + { + "input": "Definition: something described as human EHMT1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 139 kb in length. This allele, which encodes histone-lysine N-methyltransferase, H3 lysine-9 specific 5 protein, plays a role in the modulation of histone methylation. Mutation of the gene is associated with chromosome 9q subtelomeric deletion syndrome.", + "output": "KMT1D (EHMT1 gene)" + }, + { + "input": "Definition: GTPase-Activating Proteins described as PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.", + "output": "ras GTPase-Activating Proteins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Adrenal Cancer described as a rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions).", + "output": "Carcinomas, Adrenal Cortical (Malignant neoplasm of adrenal cortex)" + }, + { + "input": "Definition: TSCYC Questionnaire Question described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Touching other children's or adults' private parts (under or over clothes).", + "output": "TSCYC - Touching Other Private Parts (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: Lymph Node by Anatomic Site described as a lymph node located near the bifurcation of the trachea.", + "output": "Nodus tracheobronchiale lymphaticus (Mediastinal lymph node group)" + }, + { + "input": "Definition: Steroids described as synthetically made hormones possessing the steroid ring system; e.g., androgens, estrogens, and adrenocortical hormones.", + "output": "Therapeutic Steroid Hormone (Pharmaceutical Preparations)" + }, + { + "input": "Definition: Individual Behavior described as ensuring physical comfort, health and physical and mental well-being, such as by maintaining a balanced diet, and an appropriate level of physical activity, keeping warm or cool, avoiding harms to health, following safe sex practices, including using condoms, getting immunizations and regular physical examinations.", + "output": "Looking after one's health (CHAPTER 5 SELF-CARE)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan.", + "output": "tryptophan-independent indoleacetic acid anabolism (indoleacetic acid biosynthetic process)" + }, + { + "input": "Definition: response to erythropoietin described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.", + "output": "cellular response to erythropoietin (response to erythropoietin)" + }, + { + "input": "Definition: Uterine Corpus Carcinosarcoma described as the reemergence of uterine corpus carcinosarcoma after a period of remission.", + "output": "Recurrent Uterine Corpus Carcinosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the cytochrome P450 2C9 enzyme activity in a biological specimen.", + "output": "CYP2C9 Activity Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion.", + "output": "negative regulation of oestradiol secretion (Cell Function)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version Phase 1 Study 1/14/09 (C-SSRS Baseline/Screening Version Phase 1 Study 1/14/09) How many times have you had these thoughts? (Lifetime).", + "output": "CSS0307A (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)" + }, + { + "input": "Definition: something described as a recombinant form of the endogenous Transforming Growth Factor-Beta 1, a protein involved with the regulation of cell proliferation and differentiation.", + "output": "Transforming Growth Factor-Beta 1 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a pharmacological agent that acts in a reversible fashion and can be applied either locally or systemically to cause a partial or total loss of sensation and pain or to induce unconsciousness.", + "output": "Anesthetic Agent (ANESTHETICS: GENERAL TERMS)" + }, + { + "input": "Definition: Individual Behavior described as any observable response or action of an adolescent.", + "output": "adolescents behavior (Individual Behavior)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a questionnaire for self-reported satisfaction with sexual function that includes 79 items in 11 domains: interest in sexual activity, lubrication, vaginal discomfort, erectile function, global satisfaction with sex life, orgasm, anal discomfort, therapeutic aids, sexual activities, interfering factors, and screener questions.", + "output": "PROMIS Sexual Function and Satisfaction Measures (Intellectual Product)" + }, + { + "input": "Definition: Dosage Form By Route Of Administration described as liquid sterile preparation consisting of a solution intended for intravesical use or for administration by injection. Comment: This term is only to be used in cases where there is not a single predominant route of administration for the medicinal product.", + "output": "Intravesical solution/solution for injection (Dosage Form By Route Of Administration)" + }, + { + "input": "Definition: Ingestion described as secretion of saliva.", + "output": "Salivation, NOS (Functions and Abnormal Functions of the Salivary Glands)" + }, + { + "input": "Definition: Intellectual Product described as symptom Impact Questionnaire - Change bed sheets.", + "output": "SIQR - Change Bed Sheets (Intellectual Product)" + }, + { + "input": "Definition: Cell Component described as extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.", + "output": "Microfibril (Biological macromolecule)" + }, + { + "input": "Definition: something described as fragmented appearance of the epiphyses of the 4th finger.", + "output": "Fragmentation of the end part of the ring finger bones (Fragmentation of the epiphyses of the phalanges of the hand)" + }, + { + "input": "Definition: something described as human LGALS9 wild-type allele is located in the vicinity of 17q11.2 and is approximately 20 kb in length. This allele, which encodes galectin-9 protein, is involved in carbohydrate binding and may be an eosinophil chemoattractant. Overexpression of the gene may be associated with Hodgkin lymphoma.", + "output": "Lectin, Galactoside-Binding, Soluble, 9 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Cell cavity described as the region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.", + "output": "Perinuclear Cisternal Space (Cardinal cell part)" + }, + { + "input": "Definition: something described as indicates a platelet count of at least 50,000 per cubic millimeter.", + "output": "Platelet Count 50000 (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.", + "output": "positive regulation of meiosis I (Positive Regulation of Meiosis)" + }, + { + "input": "Definition: something described as surgical division of a tendon for relief of a deformity that is caused by congenital or acquired shortening of a muscle (Stedman, 27th ed). Tenotomy is performed in order to lengthen a muscle that has developed improperly, or become shortened and is resistant to stretching.", + "output": "tenotomies (Musculoskeletal system incision)" + }, + { + "input": "Definition: Piperazine derivative described as a drug used to treat depression. It belongs to the family of drugs called antidepressant agents.", + "output": "Nefazodone hydrochloride (Selective Serotonin Reuptake Inhibitors)" + }, + { + "input": "Definition: Intellectual Product described as a character or string that represents a microbiology specimen group.", + "output": "Microbiology Specimen Group Identifier (Intellectual Product)" + }, + { + "input": "Definition: something described as a vitamin that is soluble in fat solvents and oils (lipo-soluble). Fat-soluble vitamins include vitamins A, D, E, K, F. Absorbed with ingested dietary fat, fat-soluble vitamins are stored in moderate amounts from the gastrointestinal tract. Present in minute amounts in various foods, these vitamins are essential to maintaining normal metabolism and biochemical functions; fat malabsorption may result in fat-soluble vitamin deficiencies. Fat-soluble vitamins are found in many types of foods and may be supplemented with pharmaceutical formulations.", + "output": "Product containing fat-soluble vitamin (Medicinal product categorized by therapeutic role)" + }, + { + "input": "Definition: Finding described as co-occurrence of reticular and micronodular patterns on pulmonary high-resolution computed tomography.", + "output": "Reticulonodular pattern on pulmonary HRCT (Finding)" + }, + { + "input": "Definition: Parabasalidea described as an order of parasitic EUKARYOTES typically having four to six flagella. True cysts are known in very few species. Trichomonadida were formerly members of the class Zoomastigophora in the old five kingdom paradigm.", + "output": "Trichomonadidas (Eukaryote)" + }, + { + "input": "Definition: something described as the process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.", + "output": "myelin formation in central nervous system (myelin assembly)" + }, + { + "input": "Definition: Vitamin B6 and vitamin B6 derivative-containing product described as the 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).", + "output": "Vitamin B6-containing product (Vitamin)" + }, + { + "input": "Definition: Syndactyly described as a rare genetic non-syndromic congenital limb malformation with characteristics of unilateral fusion of second to fifth fingers, amalgamation of distal phalanges in a knot-like structure, and second and third-toe fusion. Some individuals present only with webbing between second and third toes without involvement of fingers.", + "output": "Syndactyly mitten type (Congenital Abnormality)" + }, + { + "input": "Definition: S-adenosylmethionine-dependent methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.", + "output": "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)" + }, + { + "input": "Definition: Vulva finding described as intense itching of the external female genitals.", + "output": "itch; vulva (Sign or Symptom)" + }, + { + "input": "Definition: Anorectal Infection, CTCAE described as oral intervention indicated", + "output": "Grade 2 Anorectal Infection, CTCAE (Anorectal Infection, CTCAE)" + }, + { + "input": "Definition: Fatty Acids described as a class of dietary fatty acids with the first double bond at the 6th carbon from the methyl end.", + "output": "N-6 Fatty Acid (Dietary Fatty Acid)" + }, + { + "input": "Definition: Autoantibodies described as an antiphospholipid autoantibody that reacts with beta-2-glycoprotein 1, and a member of family of autoantibodies that cause antiphospholipid antibody syndrome and may be found in system lupus erythematosus.", + "output": "AAHA (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Limb structure described as a limitation of the ability to place the forearm in a position such that the palm faces anteriorly (supination) and to place the forearm in a position such that the palm faces posteriorly (pronation).", + "output": "Limited pronation/supination of forearm (Limited elbow movement)" + }, + { + "input": "Definition: Finding described as mild symptoms", + "output": "Grade 1 Tremor, CTCAE (Tremor, CTCAE 3.0)" + }, + { + "input": "Definition: Biologically Active Substance described as dedicator of cytokinesis protein 1 (1865 aa, ~215 kDa) is encoded by the human DOCK1 gene. This protein is involved in phagocytosis, apoptosis and signaling.", + "output": "Dedicator of Cyto-Kinesis 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Parasites described as any amoebic organism that can be assigned to the species Balamuthia mandrillaris.", + "output": "Balamuthia mandrillaris (Amoebozoa)" + }, + { + "input": "Definition: Structure of tributary of femoral vein described as a superficial vein originating from the dorsal vein at the fifth toe and the dorsal venous arch of the foot; it extends up the back of the leg to empty into the popliteal vein at the knee joint.", + "output": "SMALL SAPHENOUS VEIN (Structure of tributary of popliteal vein)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 19q", + "output": "19q13.2 (Chromosome band)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.", + "output": "Staplers, Surgical (Medical staplers)" + }, + { + "input": "Definition: Neoplastic Process described as non-Hodgkin lymphoma occurring in childhood.", + "output": "NHL, childhood (Childhood Lymphoma)" + }, + { + "input": "Definition: Type Code described as a coded value specifying the kind of submission. EXAMPLE(S): original, supplement, annual report", + "output": "Submission Type Code (Intellectual Product)" + }, + { + "input": "Definition: regulation of glomerulus development described as any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.", + "output": "negative regulation of glomerulus development (Biologic Function)" + }, + { + "input": "Definition: Medical Device described as a manual ophthalmic surgical instrument is a nonpowered, handheld device intended to aid or perform ophthalmic surgical procedures. This generic type of device includes the manual corneal burr, ophthalmic caliper, ophthalmic cannula, eyelid clamp, ophthalmic muscle clamp, iris retractor clip, orbital compressor, ophthalmic curette, cystotome, orbital depressor, lachrymal dilator, erisophake, expressor, ophthalmic forcep, ophthalmic hook, sphere introducer, ophthalmic knife, ophthalmic suturing needle, lachrymal probe, trabeculotomy probe, cornea-sclera punch, ophthalmic retractor, ophthalmic ring (Flieringa), lachrymal sac rongeur, ophthalmic scissors, enucleating snare, ophthalmic spatula, ophthalmic specula, ophthalmic spoon, ophthalmic spud, trabeculotome or ophthalmic manual trephine.", + "output": "CLAMP, EYELID, OPHTHALMIC (Medical Device)" + }, + { + "input": "Definition: xenobiotic transport described as the directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other.", + "output": "m-hydroxyphenylpropionic acid transport (xenobiotic transport)" + }, + { + "input": "Definition: Intellectual Product described as supporting information that describes the nucleic acid sequencing run(s) in a study.", + "output": "Run Metadata (Metadata)" + }, + { + "input": "Definition: Gene Mutation described as a gene that makes a protein called B-RAF, which is involved in sending signals in cells and in cell growth. This gene may be mutated (changed) in many types of cancer, which causes a change in the B-RAF protein. This can increase the growth and spread of cancer cells.", + "output": "braf genes (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as human CDKN3 wild-type allele is located within 14q22 and is approximately 23 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 3 protein, may play a role in cell cycle regulation. Defects in CDKN3 allele have been identified in patients with hepatocellular carcinoma (HCC) and the allele is deleted, mutated, or overexpressed in several kinds of cancers.", + "output": "Kinase-Associated Phosphatase Gene (CDKN3 gene)" + }, + { + "input": "Definition: Skin Diseases, Vascular described as a vascular lesion defined histologically as one or more dilated blood vessels lying directly subepidermal and showing an epidermal proliferative reaction. Clinically, angiokeratoma presents as a small, raised, dark-red spot.", + "output": "Angiokeratoma (Skin Diseases, Vascular)" + }, + { + "input": "Definition: something described as a unit of electrical conductance, admittance, and susceptance. A conductor has a conductance of one siemens if an electrical potential difference of one volt produces a one ampere current in it. The conductance in siemens is the reciprocal of its resistance in ohms.", + "output": "siemens (Unit of Electrical Conductance)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in T-cell trafficking.", + "output": "monokine induced by gamma interferon (Gene or Genome)" + }, + { + "input": "Definition: Idea or Concept described as a role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.", + "output": "Gene Product Expressed In Tissue (Idea or Concept)" + }, + { + "input": "Definition: Genetic Information Processing Pathway described as tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA methylation events, are frequently involved in transcriptional changes in both tumor suppressor genes and oncogenes. Methylation of cytosine at CpG dinucleotides is a common feature of higher eukaryotic genomes. DNA methylation in the promoter regions of genes is generally correlated with gene silencing. Two underlying mechanisms have been identified. First, binding of transcription factors or enhancer blocking elements, such as CTCF, may be inhibited by DNA methylation. The second and more general mechanism involves proteins that detect methylated DNA through methyl CpG-binding domains (MBDs). Four of these proteins-MBD1, MBD2, MBD3, and MeCP2-have been implicated in methylation-dependent repression of transcription. These proteins mediate recruitment of repressor complexes that include histone deacetylases (HDACs). HDACs remove acetyl groups from lysine residues of histones H3 and H4 that results in condensation of chromatin and thus limit access of transcription factors to promoter regions of genes localized nearby. Well-studied co-repressor complexes include Sin3A and Mi-2/NuRD. MeCP2, a polypeptide characterized by an MBD and a transcriptional repression domain that specifically binds methylated DNA, copurifies with the Sin3A/HDAC corepressor complex. MeCP1 complex is composed of 10 major polypeptides including MBD2 and all of the known NuRD complex components. The two protein complexes share four polypeptides: HDAC1, HDAC2, RbAp46, and RbAp48. In addition, each complex contains unique polypeptides (Sin3A, SAP30, and SAP18 in the Sin3 complex, and Mi2, MTA1, MTA2 and MBD3 in the NuRD complex). The NuRD complex possesses nucleosome remodeling activity because of the presence of Mi2, a member of the SWI2/SNF2 helicase/ATPase family. This complex preferentially binds, remodels, and deacetylates methylated nucleosomes. MTA1 or MTA2 (metastasis-associated protein 1 or 2) expression levels are elevated in metastatic cancer cells, MTA2 modulates the enzymatic activity of the histone deacetylase core complex.", + "output": "Transcriptional Repression by DNA Methylation Pathway (Genetic Information Processing Pathway)" + }, + { + "input": "Definition: Middle pre-aortic lymph node described as middle pre-aortic lymph node group located between inferior margin of left renal vein and superior margin of inferior mesenteric artery.", + "output": "Inferior middle pre-aortic lymph node (Middle pre-aortic lymph node)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the KMT2D gene.", + "output": "KMT2D Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Neoplastic Process described as a poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity.", + "output": "Breast Large Cell Neuroendocrine Carcinoma (Invasive carcinoma of breast)" + }, + { + "input": "Definition: positive regulation of transforming growth factor beta production described as any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.", + "output": "up-regulation of transforming growth factor-beta2 production (Organism Function)" + }, + { + "input": "Definition: CPTAC Responses described as a response indication the administration of adjuvant pharmaceutical post-operative therapy is unknown.", + "output": "Adjuvant Post-operative Pharmaceutical Therapy Administration Unknown (Finding)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) In the past 30 days: How much has your health been a drain on the financial resources of you or your family?", + "output": "WD5-Drain on Financial Resources (Intellectual Product)" + }, + { + "input": "Definition: something described as GTP-binding protein SAR1b (198 aa, ~22 kDa) is encoded by the human SAR1B gene. This protein plays a role in the regulation of vesicle transport from the endoplasmic reticulum to the Golgi.", + "output": "GTP-Binding Protein B (Monomeric GTP-Binding Proteins)" + }, + { + "input": "Definition: Mardivirus described as a species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting chickens.", + "output": "MAREKS DIS VIRUS SEROTYPE 2 (Virus)" + }, + { + "input": "Definition: embryo or fetus described as having to do with an embryo, which is an early stage in the development of a plant or animal.", + "output": "Embryo (stage of pregnancy)" + }, + { + "input": "Definition: Plant described as parasitic plants that form a bushy growth on branches of host trees which are in the order Santalales. It includes the Christmas mistletoe family (VISCACEAE), the showy mistletoe family (LORANTHACEAE) and the catkin mistletoe family (Eremolepidaceae). The composition of toxins, lectins, tyramine, phenethylamines, and other compounds may be affected by the host.", + "output": "Mistletoes (Angiosperm)" + }, + { + "input": "Definition: Prostaglandins E, Synthetic described as a synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.", + "output": "E2, 16,16-Dimethylprostaglandin (Organic Chemical)" + }, + { + "input": "Definition: Device associated with nuclear medicine systems described as data management information systems designed to process, organize, and store clinical and administrative information related to radiology departments and imaging centers. These systems can be used for patient registration, result reporting, film library management, order entry, patient tracking, patient scheduling, and other administrative tasks, such as billing and accounting procedures.", + "output": "INFORMATION SYSTEMS RADIOL (Magnetic resonance imaging unit)" + }, + { + "input": "Definition: Pharmacologic Substance described as vaccine administered for the prevention or treatment of infectious protozoan disease.", + "output": "Vaccines, Protozoan (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as high dose rate radiation delivered by a radiation source contained in an intra-vaginal cylinder to target neoplasms of the vaginal cuff.", + "output": "HDR-VCB (Vaginal Cuff Brachytherapy)" + }, + { + "input": "Definition: something described as the capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.", + "output": "DIS RESISTANCE (Organism Function)" + }, + { + "input": "Definition: Daily or Recreational Activity described as equipping and arranging a living space with furniture, fixtures and other fittings and decorating rooms.", + "output": "Furnishing a place to live (Acquiring a place to live)" + }, + { + "input": "Definition: something described as a type of lymphoma that tends to grow and spread slowly, and has few symptoms. Also called indolent lymphoma.", + "output": "Low grade lymphoma (Lymphoma by Working Formulation)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radioimmunotherapeutic humanized murine monoclonal antibody (LL2) directed against the CD22 pan-B-cell antigen and chelated to the radioisotope yttrium-90 (Y 90). Y 90 humanized monoclonal antibody LL2 binds to tumor cells expressing CD22, delivering a cytotoxic dose of beta radiation.", + "output": "Monoclonal antibody LL2, yttrium Y 90 (Immunologic Factor)" + }, + { + "input": "Definition: Organic Chemical described as an anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.", + "output": "Ansamycins (Organic Chemical)" + }, + { + "input": "Definition: Orthoses, Spine described as spine orthoses designed for external modification of the structural and/or functional characteristics of the cervical segment of the spine, that provide immobilization and/or support. Cervical spine orthoses include soft cervical orthoses (e.g., foam collars) that are intended to provide limited support and stabilization or semi-rigid and rigid orthoses that can provide total immobilization of the cervical spine. Cervical orthoses are intended mainly to reduce pain, to provide therapeutic motion control or complete immobilization of the cervical spine; they are frequently intended for therapeutic and/or daily use (i.e., functional use) after injuries or trauma.", + "output": "cervical brace (Medical Device)" + }, + { + "input": "Definition: Enzyme described as peroxiredoxin-4 (271 aa, ~31 kDa) is encoded by the human PRDX4 gene. This protein plays a role in both redox regulation and nuclear factor NF-kappa-B activation in cells.", + "output": "Peroxiredoxin-4 (Enzyme)" + }, + { + "input": "Definition: something described as the cancer Models Database (caMOD) allows researchers to retrieve and submit animal models of cancer. caMOD currently supports the Mouse Models of Human Cancer Consortium (MMHCC).", + "output": "Cancer Models Database (Databases)" + }, + { + "input": "Definition: something described as a response indicating that a person cannot pinch and has major sensory loss.", + "output": "Cannot pinch; major sensory loss (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ASN007 specifically binds to and inhibits the serine/threonine-protein kinase activities of both ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent proliferation and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream targets. It plays a key role in the proliferation, differentiation and survival of tumor cells.", + "output": "ASN007 (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Pharmacologic Substance described as a saturated medium-chain fatty acid with a 10-carbon backbone. Capric acid is found naturally in the coconut and palm kernel oils as well as the milk of various mammals.", + "output": "Fatty Acid 10:0 (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)" + }, + { + "input": "Definition: Organic Chemical described as a drug used to treat anxiety and insomnia", + "output": "Barbiturate (Pyrimidinones)" + }, + { + "input": "Definition: something described as physical location of ARHH_Gene", + "output": "4: 40021168-40068421 (Chromosome 4 Physical Location)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+).", + "output": "hypotaurocyamine kinase activity (Molecular Function)" + }, + { + "input": "Definition: Natural Disasters described as mass of snow and/or ice falling down a mountain or incline.", + "output": "Avalanches (Environmental event)" + }, + { + "input": "Definition: Cell Function described as the regulated release of interferon-beta from a cell.", + "output": "IFNB secretion (type I interferon secretion)" + }, + { + "input": "Definition: Adductor of wrist joint described as a muscle in the forearm running from the humeral and ulnar heads to the ulnar side of the wrist that flexes and abducts the hand toward the ulna.", + "output": "flexor carpi ulnaris (Skeletal muscle structure of upper limb)" + }, + { + "input": "Definition: Parotid Gland Sarcoma described as a Kaposi sarcoma arising from the parotid gland.", + "output": "Kaposi's Sarcoma of Parotid Gland (Neoplastic Process)" + }, + { + "input": "Definition: something described as a category of terminology used to qualify the information pertaining to text interpretation codes in the framework of the Pharmaceutical Quality/Chemistry, Manufacturing and Controls documents.", + "output": "Pharmaceutical Quality/CMC Interpretation Code (text) Terminology (FDA Pharmaceutical Quality/CMC Terminology)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure.", + "output": "metanephric DCT cell development (DCT cell development)" + }, + { + "input": "Definition: lipopeptide binding described as interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups.", + "output": "diacyl lipopeptide binding (lipopeptide binding)" + }, + { + "input": "Definition: CyThera ES Cell Line described as provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.", + "output": "hES-8-1 (Cell)" + }, + { + "input": "Definition: something described as luminometer software designed to process data obtained while measuring adenosine triphosphate (ATP) to evaluate organic contamination using a standard computer. This software is intended to evaluate the results of measurements performed with the luminometer; they work only with one or a few models of ATP luminometers, usually from the same manufacturer. The software may perform a variety of algorithms to provide customized reports, differentiate re-testing data, and provide data archive capabilities that enable analysis of historical records; the software may also establish limits for pass/fail interpretation. ATP organic contamination software is usually not available separate from the luminometer but may be updated (i.e., through the release of modified versions) during the life of the equipment.", + "output": "ATP (Adenosine Triphosphate) Luminometer Software (Computer software)" + }, + { + "input": "Definition: Pseudomonas described as a species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.", + "output": "Pseudomonas testosteroni (Pseudomonas)" + }, + { + "input": "Definition: Laboratory or Test Result described as an electrocardiographic finding of a non-specific abnormality of the QRS complex, which is atypical in shape, duration, amplitude, axis or polarity.", + "output": "QRS Complex Abnormality by EKG Finding (Ventricular Arrhythmia by ECG Finding)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the galactosidase alpha (GLA) gene, located at chromosome Xq22, which encodes the protein alpha-galactosidase A. Genetic variants at this locus have been associated with Fabry disease.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, GLA (Medical Device)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila Species described as molecular assay reagents intended to identify Chlamydophila pneumoniae, a bacterium of the family Chlamydiaceae, by detecting specific genetic information of the ribosomal ribonucleic acid (rRNA) of the target bacteria. These bacteria may cause respiratory infections and mild atypical pneumonia.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila pneumoniae, RRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydophila Species)" + }, + { + "input": "Definition: Lymph node group described as parietal para-aortic lymph node located around the aortic hiatus of diaphragm.", + "output": "JPS No. 16a1 lymph node (Lymph node group)" + }, + { + "input": "Definition: something described as a ginglymoid (hinge) synovial joint within the thumb connecting the proximal and distal phalanges.", + "output": "IPJ - Interphalangeal joint of thumb (Finger joint structure)" + }, + { + "input": "Definition: something described as merkel cell carcinoma with distant metastasis microscopically confirmed.", + "output": "Neuroendocrine Carcinoma of the Skin pM1 TNM Finding v8 (Merkel Cell Carcinoma Pathologic Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: Bone Marrow Diseases described as a condition characterized by aplasia of the erythroid series only. The leukocytes and platelets are not affected.", + "output": "Red-Cell Aplasias, Pure (Hematology)" + }, + { + "input": "Definition: Gene or Genome described as human AGR2 wild-type allele is located in the vicinity of 7p21.3 and is approximately 13 kb in length. This allele, which encodes anterior gradient protein 2 homolog protein, plays a role in the regulation of receptor adhesion and functioning. Overexpression of the AGR2 gene is associated with certain types of cancer such as breast and prostate cancer.", + "output": "Anterior Gradient 2 Homolog (Xenopus Laevis) Gene (AGR2 gene)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.", + "output": "deltoid tuberosity development (anatomical structure development)" + }, + { + "input": "Definition: Plant described as bowman's root.", + "output": "Gillenia trifoliata (L.) Moench (Gillenia)" + }, + { + "input": "Definition: something described as thioredoxin (105 aa, ~12 kDa) is encoded by the human TXN gene. This protein plays a role in redox reactions, signaling and immunity.", + "output": "ADF (Oxidoreductase)" + }, + { + "input": "Definition: Molecular Function described as the covalent attachment of a lipid group to the carboxy-terminus of a protein.", + "output": "C-terminal protein lipidation (protein lipidation)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.", + "output": "beta-D-mannoside mannohydrolase activity (mannosidase activity)" + }, + { + "input": "Definition: something described as simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.", + "output": "Ciliated columnar epithelium (Simple columnar epithelium)" + }, + { + "input": "Definition: Organ or Tissue Function described as sensations arising from voiding and related urinary functions.", + "output": "Sensations associated with urinary functions (Urinary functions)" + }, + { + "input": "Definition: Malignant epithelial neoplasm - category described as a malignant neoplasm which occurs mostly in the major salivary glands (most frequently in the parotid gland), but also in the minor salivary glands of the oral mucosa and the tracheobronchial tree. It is characterized by the presence of ductal structures which are lined by an inner layer of cuboidal epithelial-type cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm.", + "output": "epithelial-myoepithelial carcinoma (Malignant epithelial neoplasm - category)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.", + "output": "Phosphorus, Dietary (dietary mineral)" + }, + { + "input": "Definition: Intellectual Product described as the set of terms that have been mapped to terms with equivalent meaning in the International Classification of Disease for Oncology (ICD-O).", + "output": "Mapped ICD-O Terminology (Intellectual Product)" + }, + { + "input": "Definition: Radiation, Nonionizing described as a type of wave made when an electric field and a magnetic field are combined. Radio waves are being studied in the treatment of several types of cancer and other conditions. The radio waves are sent through needles inserted into tumor tissue and may kill cancer cells. Radio waves are also used in MRI to create detailed images of areas inside the body.", + "output": "Radio Frequency (Radiation, Nonionizing)" + }, + { + "input": "Definition: leukocyte mediated cytotoxicity described as the directed killing of a target cell by a microglial cell.", + "output": "microglial cell mediated cytotoxicity (myeloid leukocyte mediated immunity)" + }, + { + "input": "Definition: something described as no identifiable superior and/or inferior lacrimal punctum.", + "output": "Lacrimal Puncta, Absence of (Disease or Syndrome)" + }, + { + "input": "Definition: Organic Chemical described as a broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68920\" active clinical trials using this agent.", + "output": "abexinostat (Organic Chemical)" + }, + { + "input": "Definition: something described as a question about whether an individual gets or got easily full.", + "output": "Are you easily full (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Region of posterior papillary muscle of left ventricle described as region of posterior papillary muscle of left ventricle which is attached to the anterior commissural leaflet and the anterior leaflet of mitral valve.", + "output": "Anterior head of posterior papillary muscle of left ventricle (Region of posterior papillary muscle of left ventricle)" + }, + { + "input": "Definition: Organic Chemical described as an isoquinoline derivative that is used as a short-acting non-depolarizing agent.", + "output": "MIVACURIUM (M [Preparations])" + }, + { + "input": "Definition: something described as a malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years.", + "output": "Rhabdoid tumour (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts.", + "output": "cADPR-sensitive calcium-release channel activity (calcium-release channel activity)" + }, + { + "input": "Definition: Pharmacologic Substance described as a naturally occurring steroid with estrogenic activity obtained from the urine of pregnant mares.", + "output": "EQUILIN (estrogens)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the branch of medicine dealing with the FETUS and NEWBORN during the perinatal period. The perinatal period begins with the twenty-eighth week of gestation and ends twenty-eight days after birth.", + "output": "Medicine, Maternal-Fetal (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: something described as a non-metastasizing neoplasm that arises from the hilar region of the lung.", + "output": "Benign neoplasm of hilus of lung (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE RESPIRATORY SYSTEM)" + }, + { + "input": "Definition: RAD51C gene described as human RAD51C wild-type allele is located within 17q22-q23 and is approximately 3 kb in length. This allele, which encodes DNA repair protein RAD51 homolog 3 protein, may play a role in meiotic recombination and repair of damaged DNA.", + "output": "RAD51 Homolog C Gene (Gene or Genome)" + }, + { + "input": "Definition: regulation of motor neuron migration described as any process that modulates the frequency, rate or extent of lateral motor column neuron migration.", + "output": "regulation of lateral motor column neuron migration (Cell Function)" + }, + { + "input": "Definition: Abnormal Blood Chemistry and Hematology Test Result described as an elevated concentration of alkaline phosphatase in the blood.", + "output": "Alkaline phosphatase increased (Finding)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", + "output": "alpha-D-mannoside mannohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival.", + "output": "4-(4-((4-Chloro-3-(trifluoromethyl)phenyl)carbamoylamino)phenoxy)-N-(trideuteriomethyl)pyridine-2-carboxamide (Pharmacologic Substance)" + }, + { + "input": "Definition: Methylation described as the covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.", + "output": "macromolecule methylation (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Cell Function described as the insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle where this would not normally be found. The presence of excess lipid stores in skeletal muscle cells interferes with energy metabolism, impairing glucose oxidation and insulin response. Skeletal muscle is one of the primary glucose-consuming tissues, giving it a central role in insulin resistance. The increased risk of diabetes associated with obesity may be caused by increased lipid deposits in skeletal muscle and liver, creating insulin resistance. Leptin is a peptide hormone secreted by adipose tissue that has been associated with many processes. One of the target tissues of leptin is the hypothalamus where it can act to regulate feeding behavior and metabolism. Another leptin target is skeletal muscle. Activation of leptin signaling in skeletal muscle activates the AMP-activated protein kinase (AMP-kinase), known to play a key role in signaling in response to nutrients throughout evolution. AMPK phosphorylates and inactivates the enzyme ACC, acetyl-CoA carboxylase. ACC catalyzes the production of malonyl-CoA from acetyl-CoA. Malonyl-CoA in turn is an inhibitor of the import of fatty acids into mitochondria by carnitine palmitoyltransferase I for oxidation and energy production. In the presence of leptin, AMPK is activated, ACC is inhibited, and malonyl-CoA levels fall, increasing the oxidation of fatty acids and reducing the lipid content of cells. The reduced lipid content in skeletal muscle allows insulin signaling and glucose consumption to return to their normal levels, reducing insulin resistance.", + "output": "Reversal of Insulin Resistance by Leptin (Cell Function)" + }, + { + "input": "Definition: Microbiology procedure described as a measurement of the Mycoplasma pneumoniae in a biological specimen.", + "output": "MPN (Laboratory Procedure)" + }, + { + "input": "Definition: negative regulation of phosphatase activity described as any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.", + "output": "negative regulation of alkaline phosphatase activity (negative regulation of phosphatase activity)" + }, + { + "input": "Definition: Anatomical Abnormality described as absence (agenesis) or underdevelopment of one or more of the proximal phalanges of the 4th toe.", + "output": "Absent/small innermost 4th toe bone (Aplasia/Hypoplasia of the 4th toe)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.", + "output": "bulbus arteriosus development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a population of T lymphocytes polarized by rapamycin with potential immunomodulating activity. The autologous T cells collected from the patient were co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo in the presence of rapamycin, an immunosuppressive drug, and then infused back into the same patient. Both CD3 and CD28 are required for full T cell activation. These lymphocytes expressed anti-apoptotic bcl-2 family member proteins (reduced Bax, Bak; increased phospho-Bad); maintained mitochondrial membrane potentials; and displayed reduced apoptosis. Adoptive transfer of this type of T cell potentially induces an anti-apoptotic Th1/Tc1 effector phenotype by promoting autophagy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95080\" active clinical trials using this agent.", + "output": "rapamycin-polarized Th1/Tc1 autologous T lymphocytes (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: something described as an island between the Caribbean Sea and the North Atlantic Ocean, about one-half of the way from Puerto Rico to Trinidad and Tobago.", + "output": "DMA (Country)" + }, + { + "input": "Definition: Mexican State described as a state in Mexico comprising the southern half of the Baja California peninsula. Its capital is La Paz.", + "output": "Baja California Sur (Mexican State)" + }, + { + "input": "Definition: Quantitative Concept described as a natural number greater than 9 and less than 11 and the quantity that it denotes: the sum of nine and one.", + "output": "10 (Arabic numeral)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the regulation of gene expression and plays a role in the development of carcinoma of the breast.", + "output": "microRNA 516-3 (Gene or Genome)" + }, + { + "input": "Definition: Lipomatous neoplasm described as a benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.", + "output": "adipose tissue myxolipoma (lipoma of adipose tissue)" + }, + { + "input": "Definition: ethyl ether described as an oxazolidinone with centrally-acting skeletal muscle relaxant properties. Although the exact mechanism through which metaxalone exerts its effect is largely unknown, it might be due to general central nervous system (CNS) depression. Metaxalone has no direct effect on the contractile mechanisms of striated muscle, the motor end plate, or the nerve fiber.", + "output": "Metassalone (Muscle relaxants)" + }, + { + "input": "Definition: something described as an organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome.", + "output": "vacuole-isolation membrane contact site (Cell Component)" + }, + { + "input": "Definition: something described as instruction intended to lead to physical activity related knowledge and change physical activity.", + "output": "Physical activity guidance (Procedure with a clinical finding focus)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid preparation consisting of an emulsion intended for administration to the stomach or duodenum by means of a suitable applicator.", + "output": "Gastroenteral emulsion (Biomedical or Dental Material)" + }, + { + "input": "Definition: cullin-RING ubiquitin ligase complex described as a ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.", + "output": "CDL2 complex location (Cell Component)" + }, + { + "input": "Definition: something described as this gene plays a role in leukocyte intercellular adhesion.", + "output": "CD11A (Cell Adhesion Molecule Gene)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) Grip: are you able to turn faucets on and off?", + "output": "HAQ01-Turn Faucets On And Off (Intellectual Product)" + }, + { + "input": "Definition: SETD2 Protein Variant described as a change in the amino acid residue at position 1265 in the histone-lysine methyltransferase SETD2 protein where glutamic acid has been replaced one or more non-canonical amino acids followed by a stop codon.", + "output": "HIF-1 E1265fs (SETD2 Protein Variant)" + }, + { + "input": "Definition: Organism Function described as the process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage.", + "output": "nonphotochemical quenching (Organism Function)" + }, + { + "input": "Definition: Teaching Methods described as approach to teaching and learning emphasizing the student's right to make decisions and viewing the teacher as a facilitator of learning rather than a transmitter of knowledge. May include grouping of students across grades, independent study, individualized rates of progression, open-plan schools without interior walls, or unstructured time and curricula.", + "output": "Open Classroom Method (Teaching & Teaching Methods)" + }, + { + "input": "Definition: Reactive Cutaneous Fibrous Lesion described as progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair; spreads to surrounding tissues.", + "output": "Keloid of skin (Collagen Diseases)" + }, + { + "input": "Definition: Musculoskeletal Diseases described as unilateral atrophy (reduction in size) of a leg.", + "output": "Asymmetric lower limb shortening (Lower Extremity Deformities, Congenital)" + }, + { + "input": "Definition: Intellectual Product described as brief Pain Inventory Short Form (BPI2) (copyright 1991 Charles S. Cleeland, PhD, Pain Research Group, All Right Reserved).", + "output": "BPI SHORT FORM (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans.", + "output": "regulation of alpha-glucan synthesis (Cell Function)" + }, + { + "input": "Definition: Immunologic Factor described as a recombinant, bivalent, human papillomavirus (HPV) vaccine, containing virus-like particles for HPV types 16 and 18 linked to the adjuvant ASO4, with potential immunoprotective and antineoplastic properties. Upon administration, HPV 16/18 L1 virus-like particle/ASO4 vaccine may generate humoral and cellular immunity against HPV types-16 and -18 antigens, thereby preventing cervical infection upon exposure to HPV types 16 and 18. In addition, this agent may stimulate an antitumoral cellular immune response against cervical cancer associated with HPV infection.", + "output": "HPV 16/18 L1 VLP/AS04 VAC (Pharmacologic Substance)" + }, + { + "input": "Definition: Immunodeficiency associated with chromosomal abnormality described as a genetic variant of mendelian susceptibility to mycobacterial disease with characteristics of partial deficiency in IFN-gammaR2, leading to impaired response to IFN-gamma and consequently to recurrent moderately severe infections with bacillus Calmette-Gu\u00e9rin (BCG) and other environmental mycobacteria. Caused by a heterozygous mutation in the IFNGR2 gene on chromosome 21q22.1-22.2 that encodes the IFN-gamma receptor ligand binding chain 2. The 186delC mutation corresponds to the first mutation conferring an AD partial IFN-gammaR2 deficiency.", + "output": "Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: Organic Chemical described as a derivative of clofibrate. In the body clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB).", + "output": "Clofibride (Organic Chemical)" + }, + { + "input": "Definition: Hyoseridinae described as a plant genus of the family ASTERACEAE. Sesquiterpene lactone glucosides (SESQUITERPENES) have been found in it.", + "output": "Taeckholmia Boulos, 1967, nom. illeg. (Plant)" + }, + { + "input": "Definition: something described as ataxin-2 (1313 aa, ~140 kDa) is encoded by the human ATXN2 gene. This protein plays a role in the modulation of epidermal growth factor receptor internalization.", + "output": "spinocerebellar ataxia 2 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in post-transcriptional regulation; however the function remains to be elucidated. Mutations in the gene result in Ewing sarcoma and other tumors.", + "output": "Ewing sarcoma breakpoint region 1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a person having origins in any of the original peoples of Western Europe.", + "output": "WESTERN EUROPEAN (Population Group)" + }, + { + "input": "Definition: Retinoblastoma pT4 TNM Finding v7 described as retinoblastoma with tumor invading optic nerve to resection line but no extra-ocular extension is identified.", + "output": "Retinoblastoma pT4a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part I. Over the past 7 days, how short of breath did you get with each of these activities?: Sweeping or mopping. Please indicate why you did not do this in the past 7 days.", + "output": "FACIT-Dyspnea 10 Item Short Form - Part I: Sweeping/Mopping Why Not (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)" + }, + { + "input": "Definition: Health care facility described as facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required, generally for those not needing hospital services but still in need of medical assistance.", + "output": "Institutions (Treatment Facilities)" + }, + { + "input": "Definition: Primary malignant neoplasm of appendix described as a malignant neoplasm arising from the glandular epithelium of the appendix with invasion of the appendiceal wall beyond the muscularis mucosa. The majority of cases are well differentiated adenocarcinomas with mucinous stroma formation. Clinically, it may present as an abdominal mass or with symptoms of acute appendicitis. Patients with chronic ulcerative colitis are at a higher risk in developing appendiceal adenocarcinomas compared to the general population.", + "output": "Appendix Adenocarcinoma (Malignant neoplasm of large intestine)" + }, + { + "input": "Definition: Finding described as an indication that the patient has a history of alcohol use.", + "output": "Yes (Finding)" + }, + { + "input": "Definition: Hypnotherapy and/or meditation described as using hypnotherapy to work with a coma patient. Service is billed in 15-minute increments.", + "output": "Hypnotherapy coma release individual each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Respiratory System Finding described as cessation of breathing function.", + "output": "Respiratory arrest (Other ill-defined and unknown causes of morbidity and mortality)" + }, + { + "input": "Definition: ANTI-INFECTIVE AGENTS FOR BACTERIA, VIRUSES AND FUNGI described as group of napthacenecarboxamide biosynthetic antibiotics isolated from species of Streptomyces or produced semisynthetically, with a wide spectrum of antimicrobial activity.", + "output": "Tetracycline drug (Antibiotics)" + }, + { + "input": "Definition: something described as any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).", + "output": "base conversion/substitution editing (RNA modification)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as an abbreviation for a chemotherapy combination that is used to treat non-Hodgkin lymphoma and mantle cell lymphoma and is being studied in the treatment of other types of cancer. It includes the drugs rituximab, cyclophosphamide, doxorubicin hydrochloride (hydroxydaunorubicin), vincristine sulfate (Oncovin), and prednisone.", + "output": "Cyclophosphamide/Doxorubicin/Prednisone/Rituximab/Vincristine (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Radioisotopes described as a synthetic amino acid radiolabeled with carbon-11. Acting as a methyl donor, methionine C 11 is incorporated into macromolecules, where it serves as a positron emission tomography (PET) imaging agent for detecting tumors with high rates of protein synthesis.", + "output": "Methionine C11 (Carbon Radioisotopes)" + }, + { + "input": "Definition: something described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3).", + "output": "adult indolent noncontiguous non-Hodgkin lymphoma stage II (Neoplastic Process)" + }, + { + "input": "Definition: basic amino acid transmembrane transporter activity described as enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.", + "output": "arginine permease activity (Molecular Function)" + }, + { + "input": "Definition: something described as compounds which inhibit or antagonize biosynthesis or actions of integrase.", + "output": "Integrase Inhibitors (Antiviral Agents)" + }, + { + "input": "Definition: Laboratory Procedure described as the simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.", + "output": "Analysis, Tissue Array (Laboratory Procedure)" + }, + { + "input": "Definition: Operations by method described as an incision done for the purpose of performing an exploration", + "output": "Surgical exploration (Operations by method)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in a variety of important cellular processes, such as cell division.", + "output": "FLJ12655 (Gene or Genome)" + }, + { + "input": "Definition: negative regulation of lipoprotein particle clearance described as any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.", + "output": "negative regulation of low-density lipoprotein particle clearance (Cell Function)" + }, + { + "input": "Definition: Clinical Drug described as perque(TM) Bio-Quercitin Forte each 250 tablets. UPC Code 791760013507.", + "output": "perque bio-quercitin forte e (Clinical Drug)" + }, + { + "input": "Definition: General Qualifier described as a procedure to limit bias by preventing subjects and/ or study personnel from identifying which treatments or procedures are administered, or from learning the results of tests and measures undertaken as part of a clinical investigation. NOTE: Masking, while often used synonymously with blinding, usually denotes concealing the specific study intervention used. [After ICH E6 (R2) Glossary, 1.10]. The term masking is often preferred to blinding in the field of ophthalmology. [from AMA Manual of Style]. See also double-blind study, single-blind study, triple-blind study. Contrast with open-label and/or unblinded study.", + "output": "Masking (Research Activity)" + }, + { + "input": "Definition: Knowledge acquisition described as the Continuing Umbrella of Research Experience for Underrepresented Minorities Program (CURE) is a new strategy being implemented by the National Cancer Institute to expose minorities to cancer research at the high school and undergraduate levels. The program is being initiated nationwide.", + "output": "CURE (Knowledge acquisition)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the regulation of the uric acid cycle.", + "output": "ORNITHINE CARBAMOYLTRANSFERASE (Gene or Genome)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as strengthening and training the levator ani and urogenital muscles through voluntary, repetitive contraction to decrease stress, urge, or mixed types of urinary incontinence", + "output": "pelvic floor exercises (Procedure on pelvic region of trunk)" + }, + { + "input": "Definition: Quantitative Concept described as the distance (measured in the direction of propagation) between two points in the same phase in consecutive cycles of a wave.", + "output": "wavelengths (wave measure)" + }, + { + "input": "Definition: something described as performance of the Upper Limb Module for DMD Version 1.2 - Picking up coins.", + "output": "PUL 1.2 - Picking Up Coins (Intellectual Product)" + }, + { + "input": "Definition: Biologically Active Substance described as transcription factor 21 (179 aa, ~20 kDa) is encoded by the human TCF21 gene. This trancription factor is involved in epithelial-mesenchymal interactions, epicardial differentiation and kidney and lung morphogenesis.", + "output": "Transcription Factor 21 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: Gene or Genome described as human PRDM2 wild-type allele is located in the vicinity of 1p36.21 and is approximately 125 kb in length. This allele, which encodes PR domain zinc finger protein 2, plays a role in protein methyltransferase activity.", + "output": "PR Domain 2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Component of the Division of Extramural Activities described as an Initial Review Group reviews grant and cooperative agreement applications for centers, research projects, and research training activities in the areas of cancer cause, diagnosis, treatment, and prevention; and contract proposals relating to all facets of cancer.", + "output": "NCI Initial Review Group (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as clothing, frequently including a helmet, with accessory evacuation devices that permit recovery of shed body particles. Body exhaust systems are worn by surgical staff (e.g., for orthopedic procedures) in order to provide an ultraclean environment for the patient.", + "output": "Body exhaust system (Medical Device)" + }, + { + "input": "Definition: Parenteral Route of Drug Administration described as administration behind the pons or behind the eyeball.", + "output": "retrobulbar (Functional Concept)" + }, + { + "input": "Definition: RNA described as RNA molecules found in the nucleus either associated with chromosomes or in the nucleoplasm.", + "output": "RNA, Nuclear (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Enzyme described as a family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.", + "output": "hydroxyalkyl protein kinase (Enzymes)" + }, + { + "input": "Definition: something described as a test that measures the spray pattern characteristics, including shape and size of the evolving spray cloud under defined experimental and instrumental test conditions.", + "output": "Plume Geometry (quality assurance)" + }, + { + "input": "Definition: Organophosphate insecticide described as agricultural insecticide highly toxic to humans and animals.", + "output": "PARATHION (Organothiophosphate pesticides)" + }, + { + "input": "Definition: Cutaneous Melanoma Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. The clinical distant metastasis TNM findings for cutaneous melanoma include M0, M1a, M1b, and M1c.", + "output": "Cutaneous Melanoma Clinical Distant Metastasis TNM Finding v7 (Cutaneous Melanoma Clinical TNM Finding v7)" + }, + { + "input": "Definition: something described as having calcium accumulation in the body", + "output": "calcifying (Qualitative Concept)" + }, + { + "input": "Definition: something described as patient Health Questionnaire - 9 (PHQ-9) (Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med 2001; 16:606-613).", + "output": "Patient Health Questionnaire-9 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as this gene plays a role in transcription regulation, DNA repair, DNA replication and chromosomal stability.", + "output": "H2AC11 gene (Gene or Genome)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as this syndrome has characteristics of sex reversal in males with a 46, XX (SRY-negative) karyotype, palmoplantar hyperkeratosis and a predisposition to squamous cell carcinoma. To date, five cases (four of whom were brothers) have been described.", + "output": "Palmoplantar keratoderma, 46,XX sex reversal, predisposition to squamous cell carcinoma syndrome (Skin Abnormalities)" + }, + { + "input": "Definition: Disease or Syndrome described as a subtype of idiopathic generalized epilepsy, whose manifestations occur around puberty, associated with mutation(s) in the EFHC1 gene, encoding EF-hand domain-containing protein 1.", + "output": "Juvenile Absence Epilepsy (Disease or Syndrome)" + }, + { + "input": "Definition: Cell described as a grouping of hematopoietic cells derived from monocytes.", + "output": "Histiocytic and Dendritic Cell (Cell)" + }, + { + "input": "Definition: RAD54L Gene Mutation described as a change in the nucleotide sequence of the RAD54L gene that is associated with increased risk of disease.", + "output": "Deleterious RAD54L Gene Mutation (Deleterious Homologous Recombination Pathway Gene Mutation)" + }, + { + "input": "Definition: Inorganic Chemical described as a colorless, flammable, poisonous liquid, CS2. It is used as a solvent, and is a counterirritant and has local anesthetic properties but is not used as such. It is highly toxic with pronounced CNS, hematologic, and dermatologic effects.", + "output": "Disulfide, Carbon (Inorganic Chemical)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm.", + "output": "ribonucleoprotein complex export from cell nucleus (RNA export from nucleus)" + }, + { + "input": "Definition: detection of stimulus involved in mitotic cell cycle checkpoint described as the series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint.", + "output": "detection of stimulus involved in mitotic cell cycle cell size control checkpoint (detection of stimulus involved in mitotic cell cycle checkpoint)" + }, + { + "input": "Definition: something described as a character or string that represents the long name of the cardiovascular system findings assessment.", + "output": "Cardiovascular System Findings Test (Test Name)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the NOP10 gene.", + "output": "NOLA3 Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as inner aspect of the upper lip vermilion (normally apposing the teeth) visible in a frontal view, i.e., the presence of an everted upper lip.", + "output": "Everted prominent upper lip (Oral cavity)" + }, + { + "input": "Definition: Organism described as bacteria and other organisms that live inside the intestines. They help digest food. Vitamins such as biotin and vitamin K are made by gut flora.", + "output": "Intestinal Flora (Microbiome)" + }, + { + "input": "Definition: Fibrillins described as a fibrillin (FBN2) that functions to regulate the assembly of ELASTIC FIBERS. Mutations in the FBN2 gene are associated with congenital contractural ARACHNODACTYLY.", + "output": "Fibrillin-2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: CPTAC Questions described as a question about whether the new disease is multifocal.", + "output": "Is the New Disease Multifocal (CPTAC Questions)" + }, + { + "input": "Definition: something described as catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.", + "output": "putrescine aminopropyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Wounds, Penetrating described as traumatic or experimentally induced separation of the head from the body in an animal or human.", + "output": "avulsion; head, complete (Wounds, Penetrating)" + }, + { + "input": "Definition: Medical Device described as thermometer covers designed to sheathe or encase the elongated ear canal probes of tympanic thermometers, providing a sanitary protective barrier to prevent cross-contamination during temperature taking. Ear thermometer probe covers are disposable and are made of thin, flexible, transparent plastic.", + "output": "Probe Thermometer Covers (Medical Device)" + }, + { + "input": "Definition: Conceptual Entity described as specifies whether the receiver received the report. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "ReportReceiver.receivedIndicator (Conceptual Entity)" + }, + { + "input": "Definition: something described as a sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis.", + "output": "Paget Osteosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: regulation of circadian rhythm described as any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.", + "output": "up regulation of circadian rhythm (positive regulation of biological process)" + }, + { + "input": "Definition: something described as a process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.", + "output": "protein localisation to cytoplasmic microtubule (Cell Function)" + }, + { + "input": "Definition: something described as an essential cofactor for the degradation of G(M2)GANGLIOSIDE by lysosomal BETA-N-ACETYLHEXOSAMINIDASES. Genetic mutations resulting in loss of G(M2) activator protein are one of the causes of TAY-SACHS DISEASE, AB VARIANT.", + "output": "Activator Protein, GM2 (Sphingolipid Activator Proteins)" + }, + { + "input": "Definition: Structure of vortex of the heart described as vortex of heart which is continuous with the myocardium of left ventricle.", + "output": "Left vortex of heart (Structure of vortex of the heart)" + }, + { + "input": "Definition: Bacterium described as a species of gram-negative, aerobic bacteria that is a fast-growing and soybean-nodulating innoculant.", + "output": "Rhizobium fredii (Ensifer)" + }, + { + "input": "Definition: Antineoplastic Plant Product described as an alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.", + "output": "Epipodophyllotoxin Compound (Topoisomerase II Inhibitors)" + }, + { + "input": "Definition: something described as cullin-3 (768 aa, ~89 kDa) is encoded by the human CUL3 gene. This protein plays a role in protein ubiquitination and cell cycle arrest.", + "output": "KIAA0617 (Biologically Active Substance)" + }, + { + "input": "Definition: response to amino acid described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus.", + "output": "response to L-thialysine (response to amino acid)" + }, + { + "input": "Definition: MDS-UPDRS Questionnaire Question described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Over the past week, have you had trouble with urine control?", + "output": "MDS-UPDRS - Urinary Problems (MDS-UPDRS Questionnaire Question)" + }, + { + "input": "Definition: something described as this gene is involved in chromosome recombination, DNA replication and the regulation of DNA topology during transcription.", + "output": "topoisomerase (DNA) II beta 180kDa (Isomerase Gene)" + }, + { + "input": "Definition: something described as an administrative procedure that involves a medical record chart", + "output": "Medical records administrative procedure (ADMINISTRATIVE PROCEDURES AND PHYSICIAN SERVICES)" + }, + { + "input": "Definition: something described as a question about an individual's distress from the second of their other symptoms.", + "output": "Other Symptom 2 (Intellectual Product)" + }, + { + "input": "Definition: Action described as to wear away a surface with a sharp object.", + "output": "Scratching (Action)" + }, + { + "input": "Definition: FIGO Stage IIIC described as a FIGO stage term that applies to gynecologic cancers. There is no FIGO stage IIIC1 for cervical cancer; for endometrial cancer, it refers to regional metastasis to pelvic lymph nodes.", + "output": "Stage IIIC1 (Intellectual Product)" + }, + { + "input": "Definition: Emotional and mood disturbances NEC described as a psychological state of extreme happiness or elation.", + "output": "feeling high (Mental disorders)" + }, + { + "input": "Definition: Description described as a bibliographical reference in an acceptable format.", + "output": "Citation Description (Description)" + }, + { + "input": "Definition: something described as human HOXA9 wild-type allele is located within 7p15-p14 and is approximately 7 kb in length. This allele, which encodes homeobox protein Hox-A9, plays roles in both the modulation of transcription by RNA polymerase II and the development of the anterio-posterior axis.", + "output": "MGC1934 (Gene or Genome)" + }, + { + "input": "Definition: Parental state described as a sibling with whom you share a single parent.", + "output": "Half Relation (Family Group)" + }, + { + "input": "Definition: Affiliate Realms described as a country in southwestern Europe, bordering the Bay of Biscay, Mediterranean Sea, and North Atlantic Ocean, southwest of France.", + "output": "Spain (Geographic Area)" + }, + { + "input": "Definition: something described as this gene plays a role in protein ubiquitination.", + "output": "PROGESTIN-INDUCED PROTEIN (Gene or Genome)" + }, + { + "input": "Definition: Finding described as the gestational age of the subject at birth.", + "output": "gestational age at birth (Finding)" + }, + { + "input": "Definition: C-SSRS Children's Baseline/Screening Questionnaire Question described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Description of active suicidal ideation with any methods (not plan) without intent to act.", + "output": "C-SSRS Children's Baseline/Screening - Description of Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Children's Baseline/Screening Questionnaire Question)" + }, + { + "input": "Definition: Finding of musculoskeletal structure of digit of hand described as goodman syndrome is an extremely rare genetic disorder with characteristics of marked malformations of the head and face (essentially acrocephaly), abnormalities of the hands and feet (polydactyly, syndactyly, clinodactyly, camptodactyly, ulnar deviation), and congenital heart disease. There have been no further descriptions in the literature since 1979. Goodman syndrome could be a variant of Carpenter syndrome.", + "output": "Goodman camptodactyly (Congenital Abnormality)" + }, + { + "input": "Definition: something described as an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C352\" active clinical trials using this agent.", + "output": "carubicin (Organic Chemical)" + }, + { + "input": "Definition: specification of floral organ identity described as the process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized.", + "output": "specification of carpel identity (specification of floral organ identity)" + }, + { + "input": "Definition: something described as a coded value specifying the kind of reviewable unit.", + "output": "ReviewableUnit.typeCode (Type Code)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally bioavailable combination tablet containing the semisynthetic camptothecin derivative irinotecan and the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181AK, with potential antineoplastic activity. HM30181A binds to P-gp and prevents the P-gp-mediated efflux of irinotecan from tumor cells, which may result in greater intracellular concentrations of irinotecan and enhanced cytotoxicity. Retained intracellularly, the prodrug irinotecan is converted, by a carboxylesterase-converting enzyme, to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38). SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. P-gp, encoded by the MDR-1 gene, is a member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters and is overexpressed by some MDR tumors, preventing the intracellular accumulation of various cytotoxic agents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88280\" active clinical trials using this agent.", + "output": "Irinotecan/P-glycoprotein Inhibitor HM30181AK Combination Tablet (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Biosafety Level Code described as a coded value specifying an assessment of the potential risk associated with the handling of the cell culture. [Source: ATCC] EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "CellCulture.biosafetyLevelCode (Intellectual Product)" + }, + { + "input": "Definition: something described as a questionnaire designed to measure joint pain and stiffness over a 36 month period.", + "output": "Global Rating of Change in Joint Pain and Stiffness Questionnaire (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as an abnormal reduction in the quantity of three-dimensional space taken up by the pineal gland.", + "output": "Decreased pineal volume (Abnormal pineal volume)" + }, + { + "input": "Definition: Intellectual Product described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Reach: Are you able to reach and get down a 5-pound object (such as a bag of sugar) from just above your head?", + "output": "HAQ0226 (Intellectual Product)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid preparation consisting of an excipient that contains no active substances itself but is intended to be used in the preparation of a pharmaceutical product, e.g. for diluting/dissolving/dispersing the item(s) containing the active substance(s). The term is intended to cover all such excipients, with the particular specifications (e.g. sterility requirements) depending on the final product and its intended use. Comment: For labelling purposes, the term should be completed by appending the name of the medicinal product that it is used to prepare, i.e. 'Solvent for [PRODUCT NAME]'.", + "output": "Solvent for... (Solvent Dosage Form Category)" + }, + { + "input": "Definition: Medical Device described as a chin prosthesis is a silicone rubber solid device intended to be implanted to augment or reconstruct the chin.", + "output": "PROSTHESIS, CHIN, INTERNAL (Medical Device)" + }, + { + "input": "Definition: something described as an abnormal indentation of the skin in the region of the nasal tip.", + "output": "Dimpled nasal tip (Abnormality of the nasal tip)" + }, + { + "input": "Definition: something described as a preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell line, that are adenovirally-transduced to express a modified form of the human enzyme carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan. Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously administered to target brain tumor cells. hCE1m6 shows increased activity as compared to unmodified human CE.", + "output": "CE-secreting allogeneic NSCs (Cell)" + }, + { + "input": "Definition: something described as petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.", + "output": "petechial; hemorrhage (Skin lesion)" + }, + { + "input": "Definition: cellular process involved in reproduction in multicellular organism described as a cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.", + "output": "cytokinesis after male meiosis (meiotic cytokinesis)" + }, + { + "input": "Definition: Finding described as abnormally increased levels of lysine in cerebrospinal fluid. []", + "output": "Increased CSF lysine concentration (Finding)" + }, + { + "input": "Definition: something described as of or pertaining to the lateral aspects of the vertebral centrum.", + "output": "HEMICENTRIC (General Qualifier)" + }, + { + "input": "Definition: Dispensing medication described as activities to ensure the continued supply of prescribed drugs", + "output": "meds prefill nc (Preparing and/or dispensing and/or training services with or without ICD diagnosis)" + }, + { + "input": "Definition: something described as this gene may be involved in the modulation of gene expression.", + "output": "miRNA194-1 (Gene or Genome)" + }, + { + "input": "Definition: Support equipment described as bed mattresses filled with water to provide a pressure relief surface to the patient. These mattresses are typically made of several interconnected sections of water bladders enclosed in a strong plastic casing (e.g., vinyl). Water mattresses are typically filled through a valve that adapts to standard hoses; they are used to reduce the pressure delivered from the surface to the patient's skin (for the prevention of pressure sores [decubitus ulcers]).", + "output": "Mattresses, Bed, Water (Mattresses)" + }, + { + "input": "Definition: something described as brief Pain Inventory - Check Yes or No if the adjective applies to your pain: tiring.", + "output": "BPI122J (BPI Questionnaire Question)" + }, + { + "input": "Definition: something described as techniques or methods of patient care used by nurses as primary careproviders.", + "output": "Care Nursing, Primary (Care given by nurses)" + }, + { + "input": "Definition: botulinum toxin type E described as the biotoxin botulinum neurotoxin E6.", + "output": "Botulinum Toxin Type E6 (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's breast cancer surgeon was sensitive.", + "output": "Was sensitive (Intellectual Product)" + }, + { + "input": "Definition: something described as a question about how often an individual is or was bothered by problems.", + "output": "How often bothered by problems (Findings-Based Question)" + }, + { + "input": "Definition: something described as human CYP27B1 wild-type allele is located within 12q13.1-q13.3 and is approximately 5 kb in length. This allele, which encodes 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial protein, is involved in the biosynthesis of the active form of vitamin D3. Many allelic variants of the CYP27B1 gene encode proteins that are either inactive or exhibit reduced catalytic activity which, in turn, results in vitamin D-dependent rickets type I.", + "output": "CP2B (CYP27B1 gene)" + }, + { + "input": "Definition: Disorder of abdomen described as an abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below.", + "output": "abdominal abscesses (Gastrointestinal infections, site unspecified)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine chromogranin A (CgA), a soluble protein secreted by the adrenal medulla. CgA is a sensitive and specific tumor marker for various types of neuroendocrine tumors, its determination is mostly used as a general tumor marker in some carcinoid and endocrine pancreatic tumors without clinical hormone-related symptoms (i.e., nonfunctioning tumors). The determination of the CgA level is also used as a serum marker for diagnosis and therapeutic monitoring in patients with neuroendocrine tumors.", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Chromogranin A (Medical Device)" + }, + { + "input": "Definition: something described as an individual who is trained in the management and treatment of conditions of the foot, ankle, and lower extremities requiring fitting, fabricating, and adjusting of pedorthic devices.", + "output": "\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; Pedorthist (Professional or Occupational Group)" + }, + { + "input": "Definition: Amphetamine measurement described as the determination of the amount of methamphetamine present in a sample.", + "output": "Methamphetamine measurement (Substance Abuse Detection)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual can think of many ways to get out of a jam.", + "output": "Can Think of Many Ways to Get Out of a Jam (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Disorder of vitreous body and/or retina described as diseases involving the RETINA.", + "output": "Retinopathy (Disorder of eye)" + }, + { + "input": "Definition: Primary malignant neoplasm described as a malignant adenocarcinoma with sebaceous differentiation.", + "output": "ADENOCARCINOMA, SEBACEOUS, MALIGNANT (Primary malignant neoplasm of sebaceous gland)" + }, + { + "input": "Definition: negative regulation of signal transduction described as any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.", + "output": "negative regulation of N signaling pathway (negative regulation of signal transduction)" + }, + { + "input": "Definition: Structure of genital organ described as used for both human and animal populations.", + "output": "female genital (Genital system)" + }, + { + "input": "Definition: something described as symptomatic; intervention indicated", + "output": "Grade 2 Pleural effusion (Pleural Effusion, CTCAE)" + }, + { + "input": "Definition: Headache Disorders described as a primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).", + "output": "Hemicranias, Paroxysmal (Headache Disorders)" + }, + { + "input": "Definition: something described as physical location of ETV4_Gene", + "output": "17: 38978773-38960740 (Chromosome 17 Physical Location)" + }, + { + "input": "Definition: Vaginal discharge symptom described as whitish or yellowish mucosal vaginal discharge.", + "output": "LEUKORRHOEA (VAGINAL/LABIAL DISORDERS)" + }, + { + "input": "Definition: something described as substances that inhibit the SCHIZONTS stage of protozoa. There is particular interest in them as ANTIMALARIALS.", + "output": "Schizonticides (Pharmacologic Substance)" + }, + { + "input": "Definition: Manufactured Object described as products or objects, such as houses and land, clothing, food and technical goods, which serve as a medium of exchange for labour, capital goods and services.", + "output": "Tangible assets (Manufactured Object)" + }, + { + "input": "Definition: Gastrointestinal Neuroendocrine Tumor Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of gastric neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.", + "output": "Gastric Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v7 (Gastrointestinal Neuroendocrine Tumor Clinical TNM Finding v7)" + }, + { + "input": "Definition: something described as a material applied to the inside of the dental cavity, for protection or insulation of the surface.", + "output": "Liner, dental (Biomedical or Dental Material)" + }, + { + "input": "Definition: catheter device described as an embolectomy catheter is a balloon-tipped catheter that is used to remove thromboemboli, i.e., blood clots which have migrated in blood vessels from one site in the vascular tree to another.", + "output": "Catheters, Vascular, Embolectomy/Thrombectomy (catheter device)" + }, + { + "input": "Definition: Medical Device described as an AC-powered dynamometer is an AC-powered device intended for medical purposes to assess neuromuscular function or degree of neuromuscular blockage by measuring, with a force transducer (a device that translates force into electrical impulses), the grip-strength of a patient's hand.", + "output": "DYNAMOMETER, AC-POWERED (Medical Device)" + }, + { + "input": "Definition: Symptoms described as weighing well above a person's ideal weight, generally characterized as a Body Mass Index (BMI) of 30 and above.", + "output": "obese (High body weight)" + }, + { + "input": "Definition: Thionucleotides described as guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.", + "output": "gamma-Thio-GTP (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as acidic leucine-rich nuclear phosphoprotein 32 family member B (251 aa, ~29 kDa) is encoded by the human ANP32B gene. This protein is involved in the regulation of both the cell cycle and apoptosis.", + "output": "SSP29 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision of a pharmacist.", + "output": "Suppliers; Pharmacy, Clinic Pharmacy (Health Care Related Organization)" + }, + { + "input": "Definition: Anti-influenza Agents described as the hydrochloride salt form of rimantadine, a cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.", + "output": "Rimantadine hydrochloride (R [Preparations])" + }, + { + "input": "Definition: something described as adrenal cancer with tumor of any size. There is invasion of the fat that surrounds the adrenal gland.", + "output": "pT3 ENSAT Staging Finding v7 (Finding)" + }, + { + "input": "Definition: AQ20 Questionnaire Question described as airway Questionnaire 20 (AQ20) Do you get breathless doing housework?", + "output": "AQ01-Get Breathless Doing Housework (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease. Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.", + "output": "Stage IVA Carcinoma of the Mouth (Neoplastic Process)" + }, + { + "input": "Definition: Body part described as set of organs consisting of all the teeth at defined stages of development.", + "output": "Teeth set (Anatomical set)" + }, + { + "input": "Definition: Malignant Neoplasms described as a benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9292\" active clinical trials using this agent.", + "output": "Solid tumor (Neoplasm by Special Category)" + }, + { + "input": "Definition: MISCELLANEOUS BELIEFS described as philosophy that asserts commitment to the use of reason and observation to serve human need and interest.", + "output": "Humanism, NOS (Religious affiliation)" + }, + { + "input": "Definition: Tissue membrane described as the thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.", + "output": "Membrane, Extra-Embryonic (Tissue membrane)" + }, + { + "input": "Definition: something described as the number of brothers that are biologically related to the subject.", + "output": "BIOBRON (Numbers)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as an arsenical that has been used as a dermatologic agent and as an herbicide.", + "output": "cacodylic acid (Arsenicals)" + }, + { + "input": "Definition: O [Preparations] described as an element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.", + "output": "Oxygen (O [Preparations])" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.", + "output": "chloroplast targeting sequence binding (signal sequence binding)" + }, + { + "input": "Definition: Disease or Syndrome described as a genetically inherited anomaly of glycogen metabolism and a form of glycogen storage disease characterized by fasting hypoglycemia. It is an extremely rare disease; about 20 cases have been reported in the literature so far. The disease appears in infancy or in early childhood. Patients present with morning fatigue and fasting hypoglycemia (without hepatomegaly) associated with hyperketonemia but without hyperalaninemia or hyperlactacidemia. After meals, major hyperglycemia associated with lactate and alanine increase and hyperlipidemia is observed. Caused by mutations in the GYS2 gene (12p12.2). Transmission is autosomal recessive.", + "output": "Hepatic glycogen synthase deficiency (Glycogen synthase deficiency)" + }, + { + "input": "Definition: Bacterium described as any rod shaped bacteria that does not require oxygen to grow or respirate and has a peptidoglycan rich cell wall that stains dark purple with the Gram staining technique.", + "output": "ANAEROBIC GRAM-POSITIVE BACILLUS (Gram-Positive Bacteria)" + }, + { + "input": "Definition: Radiation described as electromagnetic radiation by which things are made visible by either sunlight or artificial lighting (e.g. candles, oil or paraffin lamps, fires and electricity), and which may provide useful or distracting information about the world.", + "output": "Light - radiation (Electromagnetic Radiation)" + }, + { + "input": "Definition: Genetic Function described as a triplet codon-amino acid adaptor activity that recognizes a CCA codon.", + "output": "CCA codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Clinical Chemistry, Control, Cerebrospinal Fluid described as clinical chemistry reagents consisting of cerebrospinal fluid (CSF) pooled from normal donors (i.e., donors with approximately normal levels of CSF constituents); they are used as reagents for quality control of assays (e.g., glucose, protein) performed in a sample of CSF.", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Control, Cerebrospinal Fluid, Normal (IVD Test Reagent/Kits, Clinical Chemistry, Control, Cerebrospinal Fluid)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+.", + "output": "2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Bilateral congenital deformity of upper limbs described as syndrome with characteristics of absence of the upper limbs and severe underdevelopment of the lower limbs. Minor facial abnormalities (depressed nasal root, upturned nose, infra-orbital creases, prominent cheeks and micrognathia) were also reported. The syndrome has been described in three fetuses born to non-consanguineous parents.", + "output": "PAPPAS (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: something described as a neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the face, upper middle back, and sternal region. It is associated with adrenocortical steroid therapy or an increase in endogenous adrenocortical hormone.", + "output": "Steroid Lipomatosis (Neoplastic Process)" + }, + { + "input": "Definition: ZFYVE9 gene described as human ZFYVE9 wild-type allele is located in the vicinity of 1p32.3 and is approximately 204 kb in length. This allele, which encodes zinc finger FYVE domain-containing protein 9, plays a role in the potentiation of tumor growth factor-beta type 1 receptor signal transduction.", + "output": "Protein Phosphatase 1, Regulatory Subunit 173 Gene (Gene or Genome)" + }, + { + "input": "Definition: Finding described as the numerical value that represents the result of a clinical assessment of muscle strength and function during abduction that is based on the Medical Research Council Manual Muscle Test. (Medical Research Council. Aids to examination of the peripheral nervous system. Memorandum no. 45, superseding War Memorandum No. 7. London: Her Majesty's Stationary Office; 1976. doi:10.1016/0022-510X(77)90205-2).", + "output": "MMTABDT (Finding)" + }, + { + "input": "Definition: Bacterium described as a proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding multiple, as of yet undisclosed, tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, live-attenuated double-deleted Listeria monocytogenes bacteria JNJ-64041809 is taken up by antigen-presenting cells (APCs), including dendritic cells (DCs). The TAAs are subsequently expressed by the APCs and then processed and presented to the immune system by both major histocompatibility complex (MHC) class I and II molecules. This activates the immune system and leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs) against the TAA-expressing tumor cells, eventually resulting in tumor cell lysis. Two genes contributing to the virulence of Lm have been removed to minimize the risk of infection. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C124843\" active clinical trials using this agent.", + "output": "JNJ-64041809 (Attenuated Bacteria Vaccine)" + }, + { + "input": "Definition: something described as a measurement of the cow milk protein antigen IgE antibody in a biological specimen.", + "output": "Cow Milk Protein Antigen IgE Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: something described as chi xiao dou", + "output": "Phaseoli / chi xiao dou (Oriental herbs and natural substances letter P)" + }, + { + "input": "Definition: primary alcohol biosynthetic process described as the chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O.", + "output": "1-butanol formation (primary alcohol biosynthetic process)" + }, + { + "input": "Definition: Laboratory Procedure described as analyzing a client/patient's blood, hair, urine and/or other sample to assess his or her allergic response(s) to up to 142 food items using an ELISA/ACT(R) Screening Food Block 142. Service is billed per test.", + "output": "ELISA/ACT(R) Screening Food Block 142 each test (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8099\" active clinical trials using this agent.", + "output": "unknown primary, squamous cell carcinoma (Carcinoma of unknown primary)" + }, + { + "input": "Definition: Manufactured Object described as a sensor designed to respond to the temperature of a space, surface, or environment.", + "output": "Temperature Sensor (Manufactured Object)" + }, + { + "input": "Definition: Population Group described as denotes the inhabitants of Ethiopia, a person from there, or their descendants elsewhere.", + "output": "ETHIOPIAN (African race)" + }, + { + "input": "Definition: Biologically Active Substance described as a peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.", + "output": "EIF 04E (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Yersinia pestis.", + "output": "yersinia pestis (Yersinia pseudotuberculosis complex)" + }, + { + "input": "Definition: Eukaryote described as any unicellular, eukaryotic organism that can be assigned to the species Babesia microti.", + "output": "Babesia microtus (Blood sporozoan)" + }, + { + "input": "Definition: Skin and subcutaneous conditions NEC described as stage II cutaneous T-cell lymphoma may be either of the following: (1) stage IIA, in which the skin has red, dry, scaly patches but no tumors, and lymph nodes are enlarged but do not contain cancer cells; (2) stage IIB, in which tumors are found on the skin, and lymph nodes are enlarged but do not contain cancer cells.", + "output": "cutaneous T-cell lymphoma, stage II (Skin and subcutaneous conditions NEC)" + }, + { + "input": "Definition: Anatomical Abnormality described as hypercellularity (increased number of cells) in the renal glomerulus but external to the glomerular capillaries, i.e., in the Bowman space or more than one layer of parietal or visceral epithelial cells. []", + "output": "Extracapillary hypercellularity (Anatomical Abnormality)" + }, + { + "input": "Definition: Health Care Activity described as assessing a client's level of interest, aptitude and/or functional level for an activity or activities in addition to his or her recreational activity history to determine if activity therapy should be incorporated into the treatment plan. Service is billed in 15-minute increments.", + "output": "Activity therapy assessment each 15 minutes (Mental health testing and/or interpretation)" + }, + { + "input": "Definition: Sarcoma of soft tissue described as the reemergence of soft tissue sarcoma after a period of remission.", + "output": "Recurrent Soft Tissue Sarcoma (Sarcoma of soft tissue)" + }, + { + "input": "Definition: Qualitative Concept described as characteristics which are necessary to allow a subject to participate in a clinical study, as outlined in the study protocol. The concept covers inclusion and exclusion criteria.", + "output": "eligibility criteria (Clinical Trials Design)" + }, + { + "input": "Definition: something described as a unit of concentration equal to femtogram per milliliter, divided by micrograms per day.", + "output": "Femtogram per Milliliter per Microgram per Day (Measurement Unit Description)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as zinc finger homeobox protein 3 (3703 aa, ~404 kDa) is encoded by the human ZFHX3 gene. This protein is involved in cellular differentiation and transcriptional repression.", + "output": "enhancer-binding protein ATBF1, human (Biologically Active Substance)" + }, + { + "input": "Definition: Finding described as susceptible to a hypersensitive reaction to natural latex rubber products, which may compromise health.", + "output": "Risk for latex allergy reaction (Defensive processes)" + }, + { + "input": "Definition: something described as mild pain", + "output": "Grade 1 Anal pain (Anal Pain, CTCAE 5)" + }, + { + "input": "Definition: Disorder of pulmonary circulation described as an embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery. []", + "output": "Embolism;pulmonary (Pulmonary heart disease and diseases of pulmonary circulation)" + }, + { + "input": "Definition: Evaluation procedure described as identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection.", + "output": "Communicable Disease Contact Tracing (Health Care Activity)" + }, + { + "input": "Definition: something described as the presence of a stenotic, i.e., constricted ureter.", + "output": "Narrowing of the ureter (Ureter)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.", + "output": "regulation of cytoplasmic microtubule depolymerization (regulation of microtubule depolymerization)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents", + "output": "Akt Inhibitor MK2206 (Organic Chemical)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the use of a device composed of thermoluminescent material for measuring exposure to IONIZING RADIATION. The thermoluminescent material emits light when heated. The amount of light emitted is proportional to the amount of ionizing radiation to which the material has been exposed.", + "output": "Thermoluminescent dosimetry (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Monoterpenes described as a monoterpene and cyclohexanol derivative that is the major component of EUCALYPTUS OIL. It is used in mouthwash, insect repellent, and as a cough suppressant, and also is widely used as a flavoring agent and solvent. It has antimicrobial properties.", + "output": "1,8 Cineol (Oils, Volatile)" + }, + { + "input": "Definition: Phosphatidylinositide 3-Kinase Inhibitor described as an inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.", + "output": "parsaclisib (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as social structure of a group as it relates to the relative social rank or dominance status of its members. Used for human or animal populations.", + "output": "Hierarchy, Dominance (Social Behavior)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 515 of the coding sequence of the IDH2 gene where guanine has been mutated to adenine.", + "output": "IDH2 c.515G>A (IDH2 Gene Mutation)" + }, + { + "input": "Definition: Neoplastic Process described as anal carcinoma with minimal stromal invasion.", + "output": "Microinvasive Anal Carcinoma (Anal carcinoma)" + }, + { + "input": "Definition: Homeopathic remedies letter C described as meadow saffron.", + "output": "Autumn crocus preparation (Pharmacologic Substance)" + }, + { + "input": "Definition: regulation of neuron projection development described as any process that modulates the frequency, rate or extent of dendrite development.", + "output": "regulation of dendrite development (regulation of neuron projection development)" + }, + { + "input": "Definition: something described as for example: -Run fast pace -Carry a heavy load upstairs or uphill", + "output": "1 - Very heavy (Finding)" + }, + { + "input": "Definition: Organic Chemical described as the essential oil of the nutmeg (Myristica fragrans). Mace oil is used as a flavoring and in pharmaceuticals for its analgesic, antispasmodic, laxative, and stimulant activities.", + "output": "Mace Oil (Natural Products)" + }, + { + "input": "Definition: Medical Device described as large safety pins designed to fasten a baby's cloth diaper in place. These devices usually consist of safety pins that have metal snap locks for the locking mechanism and/or plastic safety caps covering the pin heads to prevent the pins from accidently opening.", + "output": "Safety Pins, Diaper (Medical Device)" + }, + { + "input": "Definition: something described as an orally bioavailable, ATP-competitive, tetrahydroquinazoline (THQ)-based inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. Upon administration, GDC-0349 selectively binds to and inhibits the activity of mTOR, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol-3 (PI3K) kinase-related kinase (PIKK) family, plays an important role in the PI3K/Akt/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C133227\" active clinical trials using this agent.", + "output": "GDC 0349 (mTOR Inhibitor)" + }, + { + "input": "Definition: Benign Supratentorial Neoplasms described as a neoplasm without metastatic potential arising from the anterior or the posterior lobe of the pituitary gland. The vast majority are adenomas.", + "output": "Benign Pituitary Gland Neoplasm (Pituitary Diseases)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the thoracic vertebral column.", + "output": "Abnormality of the thoracic spine (Abnormality of the thorax)" + }, + { + "input": "Definition: Medicinal product categorized by disposition described as a topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.", + "output": "Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))- (Carboxylic Acids)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.", + "output": "Casein Kinase 1 epsilon (Enzyme)" + }, + { + "input": "Definition: Atrial arrhythmia described as an electrocardiographic finding of a regular supraventricular tachycardia due to reentry within the AV node. It is characterized by P waves which typically occur nearly simultaneously with the QRS complex, resulting in a P wave which is obscured by the QRS, merged with the QRS or which may follow the QRS.", + "output": "Atrioventricular Nodal Reentry Tachycardia (Atrial arrhythmia)" + }, + { + "input": "Definition: Antibiotics described as an antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.", + "output": "Ceftriaxon (Antibiotics)" + }, + { + "input": "Definition: Neoplastic Process described as a primary or metastatic malignant neoplasm that affects the parapharyngeal space.", + "output": "Malignant Parapharyngeal Neoplasm (Parapharyngeal Neoplasm)" + }, + { + "input": "Definition: Medical Device described as a medical magnetic tape recorder is a device used to record and play back signals from, for example, physiological amplifiers, signal conditioners, or computers.", + "output": "RECORDER, MAGNETIC TAPE, MEDICAL (Medical Device)" + }, + { + "input": "Definition: Psychotherapy described as psychotherapeutic method which seeks to uncover the causes of the client's conflicts through conscious awareness (i.e., insight) into unconscious dynamics of feelings, responses, and behavior.", + "output": "insight therapies (Psychoanalytic Therapy)" + }, + { + "input": "Definition: Finding described as vesicoureteral reflux in which there is urine reflux into the ureter and renal pelvis. Mild dilatation of the ureter and the calyces is present.", + "output": "Vesicoureteric Reflux, Grade III (Vesico-Ureteral Reflux)" + }, + { + "input": "Definition: Intellectual Product described as mini-Mental State Examination 2 Standard Version - Please copy this design.", + "output": "MMS211 (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "output": "positive regulation of cellular amide catabolic process (regulation of cellular amide catabolic process)" + }, + { + "input": "Definition: Peeling of skin described as periodic casting off FEATHERS; HAIR; or cuticle. Molting is a process of sloughing or desquamation, especially the shedding of an outer covering and the development of a new one. This phenomenon permits growth in ARTHROPODS, skin renewal in AMPHIBIANS and REPTILES, and the shedding of winter coats in BIRDS and MAMMALS.", + "output": "molted (Biological Metamorphosis)" + }, + { + "input": "Definition: Organ or Tissue Function described as orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface.", + "output": "establishment of body hair planar orientation (establishment of body hair or bristle planar orientation)" + }, + { + "input": "Definition: Canis described as the domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people.", + "output": "Canine, NOS (Duplicate concept)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a heterogeneous-nuclear ribonucleoprotein found associated with the NUCLEAR MATRIX.", + "output": "Glucocorticoid Receptor Interacting Protein 120 (Biologically Active Substance)" + }, + { + "input": "Definition: Medical Devices described as radiosurgical frame-guided computer-aided stereotactic systems designed to aid in the performance of surgical procedures from the exterior of the body using a single high dose of ionizing radiation provided by Cobalt-60 gamma radiation sources. These systems typically combine medical imaging, a rigid frame (e.g., a headframe) attached to the patient body for guidance, dedicated computer software, and a radiation delivery assembly with a patient table and a control console. Frame-guided radiosurgical linac stereotactic systems are mainly intended for use in neurosurgery (e.g., arteriovenous malformations, neuromas, adenomas, and neoplasms).", + "output": "Gamma Radiosurgical Systems, Stereotactic (Stereotactic Systems, Frame-Guided, Radiosurgical)" + }, + { + "input": "Definition: Neuroanatomy described as the representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.", + "output": "Globus Pallidus (Neuroanatomy)" + }, + { + "input": "Definition: Environmental Exposure described as the exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.", + "output": "Occupational exposure (Environmental and Occupational Exposure)" + }, + { + "input": "Definition: Cell Component described as a protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.", + "output": "IgE antibody (Cell Component)" + }, + { + "input": "Definition: Intellectual Product described as north Star Ambulatory Assessment (NSAA) Can you hop on your right leg?", + "output": "NSAA115 (NSAA Clinical Classification Question)" + }, + { + "input": "Definition: Construction of anastomosis described as a construction of a shunt using either biologic or synthetic material", + "output": "bypass graft (Operative Surgical Procedures)" + }, + { + "input": "Definition: something described as metal extractors designed to pullout small ferromagnetic foreign objects from the eye and/or the surface (e.g., skin) of the body. These devices may consist of a handheld instrument with a magnet at one end and a wire loop at the other end for mechanical extraction; or, less frequently, of an electric unit that includes the electromagnet, a power supply, controls for the intensity of the magnetic field, and switches; usually they also include several detachable probes (e.g., straight, curved) to provide better access and minimum trauma to the eye and/or other points in the surface of the body.", + "output": "Metal Extractors, Magnetic (Medical Device)" + }, + { + "input": "Definition: Enzyme described as a cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.", + "output": "cyp1a2 (Cytochrome P450)" + }, + { + "input": "Definition: something described as a coded value specifying the state and nature of the material.", + "output": "Material.formCode (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a secondary angiosarcoma that has developed in an ovarian dermoid cyst.", + "output": "Ovarian Dermoid Cyst with Angiosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Oral Prosthesis described as complete dentures designed using a set of preformed teeth that are bonded to a custom-made denture base obtained using the patient's mouth as a mold; the denture is intended for replacement of all the teeth in the upper (i.e., maxilla) or lower (i.e., mandible) jaw. These dentures are typically assembled in a dental laboratory or, less frequently, at a dentist's office; they usually consist of a dental plate that comes in standard sizes that can be contoured to custom fit the patient's mouth and a set of artificial teeth that cover a full arch (either the upper or lower). Preformed complete dentures are intended for use on edentulous alveolar ridges after tooth removal; they are no longer frequently used in current dental practice.", + "output": "false teeth (Therapeutic Device)" + }, + { + "input": "Definition: Conceptual Entity described as describes how a reporter varies from its ReporterCharacteristics sequence(s) or how a Feature varies from its Reporter sequence.", + "output": "Mismatch Information (Conceptual Entity)" + }, + { + "input": "Definition: something described as eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.", + "output": "Octanes (Alkanes)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in genes associated with diabetes mellitus type 2, a condition in which the body develops insulin resistance, leading to elevated blood glucose levels. Genetic variants at multiple loci have been associated with diabetes mellitus type 2. These reagents are intended to detect mutations in multiple diabetes mellitus type 2-associated loci simultaneously.", + "output": "IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Diabetes Mellitus Type 2, Mutation (IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Diabetes Mellitus Type 2)" + }, + { + "input": "Definition: something described as diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia).", + "output": "macroencephaly (Musculoskeletal and connective tissue disorders of skull congenital)" + }, + { + "input": "Definition: Biologically Active Substance described as bcl-2-interacting killer (160 aa, ~18 kDa) is encoded by the human BIK gene. This protein plays a role in apoptosis.", + "output": "BIK (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: CDK7 gene described as human CDK7 wild-type allele is located in the vicinity of 5q12.1 and is approximately 78 kb in length. This allele, which encodes cyclin-dependent kinase 7 protein, plays a role in protein phosphorylation and the modulation of both the cell cycle and gene transcription.", + "output": "Serine/Threonine Kinase Stk1 Gene (CDK7 gene)" + }, + { + "input": "Definition: Plant Oils described as the resinous oil tapped from the trunks of Copaifera reticulata. Copaiba oil is used medicinally for its ability to modulate the inflammatory process.", + "output": "copiba oil (Plant Oils)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as intelligence level expressed in units of chronological age and determined by comparison with other individuals of the same age using intelligence test scores.", + "output": "Mental Age (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Platelet Activation described as attachment of platelets to one another; part of the mechanism leading to the formation of a thrombus.", + "output": "Platelet aggregation, function (Physiological Processes)" + }, + { + "input": "Definition: Neoplastic Process described as an endocervical adenocarcinoma that is caused by human papillomavirus infection.", + "output": "HPV-Related Endocervical Adenocarcinoma (Cervical Adenocarcinoma)" + }, + { + "input": "Definition: Nutrition function described as functions of passing food and drink nutrients into the blood stream from along the intestines.", + "output": "nutrient absorption (Digestive functions)" + }, + { + "input": "Definition: something described as a representation of the exponential function described by the Salazar-Knowles equation, and an estimation of a subject's inspiratory capacity.", + "output": "SALKA (Pulmonary function tests)" + }, + { + "input": "Definition: Psychotic Disorders described as experimentally induced psychotic-like state or condition usually achieved through drug administration. Not to be confused with inadvertent induction of psychotic conditions resulting from toxic side effects in drug therapy. Compare TOXIC PSYCHOSES.", + "output": "Experimental Psychosis (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Molecular Function described as the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.", + "output": "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment (Molecular Function)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108.", + "output": "Selective Estrogen Receptor Modulator TAS-108 (Organic Chemical)" + }, + { + "input": "Definition: something described as this SMQ is a sub-SMQ of Cardiac arrhythmias (SMQ). For detailed description, please refer to the one in Cardiac arrhythmias (SMQ).", + "output": "Congenital and neonatal arrhythmias (Classification)" + }, + { + "input": "Definition: Ischaemic coronary artery disorders described as discomfort felt in the upper abdomen, thorax, neck, or shoulders.", + "output": "Unspecified chest pain (Abnormality of the thorax)" + }, + { + "input": "Definition: Vascular Diseases described as high blood pressure caused by an underlying medical condition.", + "output": "Secondary hypertensive syndrome (Korean Standard Classification of Disease Version 5)" + }, + { + "input": "Definition: something described as reemergence of a malignant bone neoplasm after a period of remission.", + "output": "Recurrent Malignant Bone Neoplasm (Malignant Bone Neoplasm)" + }, + { + "input": "Definition: Intellectual Product described as a patient with 1-2 IMDC risk factors.", + "output": "Intermediate (International Metastatic Renal Cell Carcinoma Database Consortium Criteria)" + }, + { + "input": "Definition: Hyperkeratosis described as the presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones.", + "output": "Cobblestone-like hyperkeratosis (Hyperkeratosis)" + }, + { + "input": "Definition: Dopamine Receptor described as d(2) dopamine receptor (443 aa, ~51 kDa) is encoded by the human DRD2 gene. This protein plays a role in dopamine binding, angiogenesis inhibition, and receptor signaling.", + "output": "DRD2 (Dopamine Receptor)" + }, + { + "input": "Definition: Immunohistochemistry described as an immunohistochemical technique to identify whey acidic protein (WAP), a major whey protein secreted in rodent's milk. WAP promoter has been used for targeting heterologous genes to the mammary gland. The technique is used in diagnostic histopathology to identify breast cancer.", + "output": "WAP Staining Method (Laboratory Procedure)" + }, + { + "input": "Definition: Disorder of skeletal system described as a general term describing features characterized by abnormal development of bones and connective tissues.", + "output": "Osteochondrodysplasia (Skeletal)" + }, + { + "input": "Definition: Body weight atomic described as a general indicator of the body fat an individual is carrying based upon the ratio of weight to height.", + "output": "Quetelet index (BODY WEIGHT AND GROWTH PROBLEMS)" + }, + { + "input": "Definition: purine nucleoside catabolic process described as the chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.", + "output": "purine ribonucleoside catabolic process (ribonucleoside catabolic process)" + }, + { + "input": "Definition: cellular response to organic cyclic compound described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.", + "output": "cellular response to ionomycin (cellular response to ether)" + }, + { + "input": "Definition: Pharmacologic Substance described as a biologically active, cystine-rich, whey-based protein isolate. Whey protein isolate is broken down in the body into cystine and glutamylcystine, which travel safely in the blood stream, upon cell entry, deliver a sustained amount of free cysteine to the cells. The available cysteine allows cells to synthesize glutathione (GSH), a tripeptide containing amino acids glycine, glutamate and cysteine, thereby maintaining and increasing intracellular GSH concentrations. GSH plays a major role as an antioxidant, thereby protecting cells from oxidative damage due to harmful substances such as free radicals and reactive oxygen compounds. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67285\" active clinical trials using this agent.", + "output": "Whey Protein Isolate (Dietary Supplements)" + }, + { + "input": "Definition: Gene Therapy Agent described as a DNA plasmid that encodes genes for both the p35 and p40 subunits of the heterodimeric human interleukin 12 (hIL-12) protein that are separated by an internal ribosome entry site (IRES) and under the control of a single cytomegalovirus (CMV) promoter, with potential immunomodulatory and antineoplastic activities. Upon administration via intratumoral injection and electroporation, the plasmid is introduced into human cells resulting in expression and highly-localized secretion of a functional IL-12 p70 protein into the tumor microenvironment (TME). IL-12 is a pro-inflammatory cytokine that plays a significant role in priming and maintaining T-helper (Th) cells, activating natural killer (NK) cells, and regulating the reactivation and survival of memory T-cells (Tm). Increased levels of IL-12 in the TME may augment host immune response against tumor cells by inhibiting regulatory T-cells (Tregs), T-helper 2 (Th2) responses, and myeloid-derived suppressor cells (MDSCs).", + "output": "Plasmid IL-12 pUMVC3-hIL-12-NGVL3 (Cancer Vaccines)" + }, + { + "input": "Definition: extrinsic component of organelle membrane described as the component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", + "output": "extrinsic component of Golgi membrane (Cell Component)" + }, + { + "input": "Definition: something described as stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as devices used to deliver a high concentration of oxygen to the patient's airway. Nonrebreathing masks include a one-way valve that prevents rebreathing of gases and a reservoir bag used for fresh gas. These devices are connected to an oxygen source with tubing and include head straps for stabilization. Nonrebreathing masks are constructed of plastic.", + "output": "MASK, OXYGEN, NON-REBREATHING (Oxygen mask)" + }, + { + "input": "Definition: Implantable Injection/Infusion Ports described as injection/infusion ports that are surgically implanted in the upper limbs so that the catheter is inserted in the basilic, cephalic, or axillary vein, with the port placed in the inner aspect of the forearm or in the upper arm. Peripheral ports can be placed using angiography or using a sensor wire/catheter tracking system, the latter of which eliminates the need for fluoroscopy.", + "output": "Ports, Injection/Infusion, Peripheral Vessel (Implantable Injection/Infusion Ports)" + }, + { + "input": "Definition: protein-containing complex described as a protein complex capable of assembling an iron-sulfur (Fe-S) cluster.", + "output": "iron-sulfur cluster assembly complex location (protein-containing complex)" + }, + { + "input": "Definition: Non-Active Implantable Devices described as a burr hole cover is a plastic or metal device used to cover or plug holes drilled into the skull during surgery and to reattach cranial bone removed during surgery.", + "output": "Bur Hole Covers (Medical Device)" + }, + { + "input": "Definition: Plant agent product described as an antitumor alkaloid isolated from VINCA ROSEA.", + "output": "Vincaleukoblastine, 22-oxo- (Antineoplastic vinca alkaloid)" + }, + { + "input": "Definition: Laboratory or Test Result described as a genetic finding indicating the absence of DNA methylation in the promoter region of the MGMT gene. This finding is associated with a poor prognosis in patients with glioblastoma.", + "output": "Unmethylated MGMT Gene Promoter (Laboratory or Test Result)" + }, + { + "input": "Definition: Neoplasms described as a progressive, proliferative disease of blood cells, originating from lymphoid cells.", + "output": "Aleukemic lymphoid leukemia [obs] (WHITE CELL AND RES DISORDERS)" + }, + { + "input": "Definition: Immunoproliferative morphology described as a disorder characterized by lymphoid hyperplasia in the lymph nodes. There are two histologic variants recognized: the hyaline-vascular type and the plasma cell type. In the hyaline vascular type there are hyalinized vessels present in the lymphoid follicles. In the plasma cell type there is pronounced plasma cell proliferation. Clinically, the disease may be localized; manifested with localized lymphadenopathy, or multicentric; manifested with generalized lymphadenopathy, fever, organomegaly, and sometimes POEMS syndrome. In contrast to patients with localized disease who are usually cured following resection of the lesion, patients with the multicentric form of the disease may follow a progressive clinical course, complicated by infection, Kaposi sarcoma or lymphoma.", + "output": "angiolymphoid hyperplasia (Immunoproliferative morphology)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the TFE3/PRCC fusion gene. This protein is comprised of the extreme N-terminal amino acids of the transcription factor E3 protein fused to the C-terminal half of proline-rich protein PRCC.", + "output": "TFE3-PRCC Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Intellectual Product described as a modified electronic platform that uses an algorithmic approach that integrates treatment summaries, self-assessments, discussion guides, and survivorship care plans to provide personalized care in cancer survivorship clinics.", + "output": "HN-STAR (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Doxorubicin Preparation described as a temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Upon intravenous administration, circulating thermosensitive liposomes are activated locally by increasing the tumor temperature to 40-41 degrees Celsius using an external heat source. The elevated temperature causes compositional changes in the liposomes, creating openings that allow for the release of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing normal tissues unexposed to heat treatment.", + "output": "lyso-thermosensitive liposomal doxorubicin (Doxorubicin Preparation)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.", + "output": "transfer ribonucleate guanine 1-methyltransferase activity (tRNA (guanine) methyltransferase activity)" + }, + { + "input": "Definition: something described as increases the activity of the enzyme polynucleotide adenylyltransferase.", + "output": "polynucleotide adenylyltransferase activator activity (Molecular Function)" + }, + { + "input": "Definition: Soft tissue lesion described as obstruction or closure of the vessels carrying blood away from the heart.", + "output": "Arterial occlusions (Pathologic Function)" + }, + { + "input": "Definition: Interpersonal Relations described as degree to which an individual is incorporated by others in their activities or is welcomed to interact with others informally. Limited to human populations.", + "output": "Social Acceptance (Social Behavior)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of seven parts of the corpus callosum (Witelson). Referred to as 'Region 6', it represents the posterior one-third of the corpus callosum minus the splenium of the corpus callosum ( Witelson-1989 ).", + "output": "isthmus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a rare, cytologically high grade carcinoma that arises from the renal parenchyma. It is characterized by the presence of prominently dilated cystic spaces in a bland, fibrotic stroma. The lining cells have large irregular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Necrosis and mitotic figures are not present. It rarely metastasizes.", + "output": "Tubulocystic Renal Cell Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Anti-Double Stranded DNA Measurement described as a measurement of the double stranded DNA IgG antibody in a biological specimen.", + "output": "DDNAIGAB (Laboratory Procedure)" + }, + { + "input": "Definition: MMSE-2 Standard Version Functional Test Question described as mini-Mental State Examination 2 Standard Version (MMSE-2 Standard Version) Now repeat those words back to me: Word 2.", + "output": "MMS2-Repeat Word 2 (MMSE-2 Standard Version Functional Test Question)" + }, + { + "input": "Definition: Finding described as lacrimal gland carcinoma with tumor measuring 2 cm or less in greatest dimension with or without extraglandular extension into the orbital soft tissue.", + "output": "Lacrimal Gland Carcinoma pT1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as using transportation to move around as a passenger, such as being driven in a car or on a bus, rickshaw, jitney, animal-powered vehicle, or private or public taxi, bus, train, tram, subway, boat or aircraft.", + "output": "Using transportation (Moving around using transportation)" + }, + { + "input": "Definition: Medical Device described as a creatine phosphokinase/creatine kinase or isoenzymes test system is a device intended to measure the activity of the enzyme creatine phosphokinase or its isoenzymes (a group of enzymes with similar biological activity) in plasma and serum. Measurements of creatine phosphokinase and its isoenzymes are used in the diagnosis and treatment of myocardial infarction and muscle diseases such as progressive, Duchenne-type muscular dystrophy.", + "output": "COLORIMETRIC METHOD, CPK OR ISOENZYMES (Medical Device)" + }, + { + "input": "Definition: Medical Device described as plunger syringes designed to introduce impression materials under high pressure during dental procedures. These devices typically consist of a barrel (e.g., octagon shaped), a screw-type plunger, and a threaded tip to attach a blunt needle; some other syringes are all-plastic disposables. Impression-material dental syringes are used to obtain a negative copy (i.e., impression) of dental or related structures (e.g., dental arch), typically for construction or assembly of a fixed restoration or denture.", + "output": "Dental Impression Material Syringes (Medical Device)" + }, + { + "input": "Definition: something described as sets of tubing and auxiliary devices designed to connect a bag of dialysis solution to the proximal end of a catheter, whose distal tip is located in a patient's abdomen, to perform ambulatory peritoneal dialysis. These sets typically consist of tubing, connectors, and a cap; some sets require a new cap each time the set is disconnected from the bag after an exchange. Typically, at the beginning of an exchange, the disposable cap is removed from the transfer set and the set is connected to a Y-tube; the branches of the Y-tube connect to the drain bag and the bag of fresh dialysis solution. After the used solution is removed from the abdomen, the transfer set is clamped; some fresh solution is allowed to flow directly into the drain bag; and as a final step of the exchange, the peritoneal cavity is refilled with fresh dialysis solution from the hanging bag.", + "output": "Continuous ambulatory peritoneal dialysis (CAPD) transfer set (Gastro-urological device)" + }, + { + "input": "Definition: something described as microwave surgical units that use needle-like antennas for energy radiation. These units include a microwave generator typically of 100-watt energy and 2.45 GHz frequency, a coaxial cable to transmit the energy, and needle radiators (i.e., antennas). The needles are positioned surrounding the tissue to be resected (e.g., tumor), power is applied successively to each needle creating a continuous boundary of coagulated tissue surrounding the tumor; hemostasis of vessels up to 2 mm in diameter is possible. The tumor is removed using a scalpel or an electrosurgical unit. Needle microwave radiator surgical units are used in open surgery of the liver and spleen; they are also used in endoscopic and laparoscopic surgical applications (e.g., to control bleeding in the digestive tract).", + "output": "Microwave Surgical Units, Needle Radiator (Microwave Surgical Units)" + }, + { + "input": "Definition: regulation of presynapse organization described as any process that modulates the frequency, rate or extent of terminal button organization.", + "output": "regulation of bouton organization (Organ or Tissue Function)" + }, + { + "input": "Definition: Finding described as a finding that generally has features of hypertrophy and karyomegaly.", + "output": "Hypertrophy and Karyomegaly (Physical shape)" + }, + { + "input": "Definition: Fungus described as a species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.", + "output": "Neurospora crassa (Neurospora)" + }, + { + "input": "Definition: Fabaceae described as a plant genus of the family FABACEAE. Canavalia ensiformis is the source of CONCANAVALIN A.", + "output": "Canavalia (Fabaceae)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIIB includes: T3b, N0, M0. T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "FIGO Stage IIIB Carcinoma of Fallopian Tube (Neoplastic Process)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (percentage) of the rapid eye movement (REM) sleep time to total sleep time.", + "output": "REMTST (Laboratory Procedure)" + }, + { + "input": "Definition: Basal lamina described as similar to heparin but with some L-iduronic acid residues.", + "output": "Heparan sulphate (Glycosaminoglycans)" + }, + { + "input": "Definition: Hypothalamic and pituitary hormone, NOS described as group of soluble proteins derived from the precursors of vasopressin, oxytocin and related hormones, secreted in hypothalmus; serve as binding proteins for vasopressin and oxytocin and may contribute to hormone storage and transport.", + "output": "Neurophysins (Proteins)" + }, + { + "input": "Definition: Adrenal Cortex Carcinoma by AJCC v7 Stage described as cancer of the adrenal gland that is larger than 5 centimeters (about 2 inches) and is found in the adrenal gland only.", + "output": "Stage II Adrenal Cortex Cancer (Neoplastic Process)" + }, + { + "input": "Definition: something described as forceps with scissorlike handles, used to atraumatically grasp, hold, and exert traction or manipulation on the lungs and parenchyma during surgery. They typically have broad, flat blades (usually triangularly shaped or curved).", + "output": "Forceps, Lung (Medical Device)" + }, + { + "input": "Definition: Food described as botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.", + "output": "Nut (Nuts and seeds)" + }, + { + "input": "Definition: hydrogen biosynthetic process described as the chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria.", + "output": "hydrogen generation via nitrogenase (Biologic Function)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis.", + "output": "Stage IV Breast Cancer AJCC v6 and v7 (Neoplastic Process)" + }, + { + "input": "Definition: Created By described as the name of the entity who created the content item.", + "output": "Content Item Creator (Qualitative Concept)" + }, + { + "input": "Definition: something described as wheelchair ramps that are designed to be stationary and intended to be installed permanently onto buildings. They are usually bolted or cemented in place. They are intended to facilitate access by people who use wheelchairs or scooters.", + "output": "Wheelchair Ramps, Stationary (Medical Device)" + }, + { + "input": "Definition: Volume per unit volume described as a measure of volume concentration expressed as the number of milliters of a dissolved substance per deciliter of solution.", + "output": "mls/dl (Quantitative Concept)" + }, + { + "input": "Definition: Aerotolerant anaerobic bacteria described as a taxonomic family of photosynthesizing bacterium, the majority of which are purple non-sulfur bacterium, in the phylum Proteobacteria that includes the genera Azospirillium, Inquilinus and Rhodospirillum, among others.", + "output": "PURPLE NONSULFUR BACT (Proteobacteria)" + }, + { + "input": "Definition: something described as needles designed for the initial percutaneous insertion of a catheter. These needles typically consist of a hollow, blunt, tapered cannula with a sharp obturator inside. Catheter-insertion needles may be used to introduce drainage catheters in wounds, for initial introduction of spinal catheters, for initial introduction of peritoneal catheters for dialysis and/or drug infusion, and, more frequently, for the insertion of percutaneous venous and/or arterial catheters following the Seldinger technique. Dedicated catheter introduction needles are also used in a variety of intravascular introducers (e.g., peripheral, midline, central venous) and also in catheterization procedure kits and trays (e.g., peritoneal dialysis, spinal catheterization, angiography, intravascular).", + "output": "Needles, Catheter Introduction (Device Labeled for Single Use)" + }, + { + "input": "Definition: Finding described as a medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle.", + "output": "Moderately reduced ejection fraction (Finding)" + }, + { + "input": "Definition: something described as an oligopeptide produced by various bacteria which acts as a protease inhibitor.", + "output": "L-Valinamide, N2-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)- (Oligopeptides)" + }, + { + "input": "Definition: Family Surgical History described as PCI is the placement of an angioplasty guide wire, balloon, or other device (e.g., stent, atherectomy, brachytherapy, or thrombectomy catheter) into a native coronary artery or CABG for the purpose of mechanical coronary revascularization. The assessment of coronary lesion severity via intravascular ultrasound, coronary flow reserve, or fractional flow reserve is not considered to be a PCI procedure.", + "output": "Family History of Percutaneous Coronary Intervention (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human SLC1A2 wild-type allele is located within 11p13-p12 and is approximately 169 kb in length. This allele, which encodes excitatory amino acid transporter 2 protein, is involved in the regulation of both amino acid transport and synaptic transmission. Mutation and deletion of the gene are associated with amyotrophic lateral sclerosis.", + "output": "EAAT2 (SLC1A2 gene)" + }, + { + "input": "Definition: Medical Device described as total upper-limb support orthoses designed to provide support and some degree of movement restriction to an upper limb by means of a soft sling. These orthoses typically consist of a loop of fabric or other soft material, including a band suspended from the neck and/or shoulder and a wider segment around the forearm. Sling upper-limb support orthoses are frequently used to assist the limb function by positioning it in an appropriate resting position during rehabilitation after injuries and/or trauma; they are also used to assist the limb by positioning it in an appropriate position, thus compensating for muscle weakness. Additional movement restriction is possible by attaching the sling to the user trunk. Dedicated slings attached to an external (e.g., wheelchair) bar are also available.", + "output": "Swathe Slings (Clinical appliance)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient have periods when he/she refuses to cooperate or won't let people help him/her? Is he/she hard to handle?", + "output": "NPI1C (Intellectual Product)" + }, + { + "input": "Definition: something described as a rheumatoid factor immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the rheumatoid factor (antibodies to immunoglobulins) in serum, other body fluids, and tissues. Measurement of rheumatoid factor may aid in the diagnosis of rheumatoid arthritis.", + "output": "SYSTEM, TEST, RHEUMATOID FACTOR (Medical Device)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the extent to which sex is or was enjoyable.", + "output": "Extent of Sexual Enjoyment (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as form from constituents.", + "output": "ft. (Functional Concept)" + }, + { + "input": "Definition: porphyrin-containing compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.", + "output": "heme degradation (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as human ATG4C wild-type allele is located in the vicinity of 1p31.3 and is approximately 81 kb in length. This allele, which encodes cysteine protease ATG4C protein, is involved in proteolysis during autophagy.", + "output": "AUTL1 (ATG4C gene)" + }, + { + "input": "Definition: something described as the determination of the location on a nucleotide sequence that is considered to be the beginning of a genetic region of interest.", + "output": "Genetic Sequence Start Location (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as expanded Disability Rating Scale - Postacute Interview Caregiver Version - Does [name] understand what eating or feeding utensils or equipment are for and how they should be used?", + "output": "ED104 2 (Intellectual Product)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire - Taking everything into consideration, during the past week how satisfied have you been with your: Family relationships?", + "output": "QLES1-Family Relationships (Intellectual Product)" + }, + { + "input": "Definition: something described as a family of structurally related neurotoxic peptides from mollusk venom that inhibit voltage-activated entry of calcium into the presynaptic membrane. They selectively inhibit N-, P-, and Q-type calcium channels.", + "output": "omega Conotoxins (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Malignant Thymoma described as a type AB thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.", + "output": "Malignant Type AB Thymoma (Thymic epithelial tumor)" + }, + { + "input": "Definition: sequence-specific DNA binding described as interacting selectively and non-covalently with single-stranded DNA of a specific nucleotide composition.", + "output": "sequence-specific single stranded DNA binding (single-stranded DNA binding)" + }, + { + "input": "Definition: Adenoid cystic carcinoma of the oral cavity described as the reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission.", + "output": "Recurrent Adenoid Cystic Carcinoma of the Mouth (Adenoid cystic carcinoma of the oral cavity)" + }, + { + "input": "Definition: G [Preparations] described as an antifungal agent used in the treatment of TINEA infections.", + "output": "(+)-griseofulvin (Allergen class)" + }, + { + "input": "Definition: Withdrawal and rebound effects described as processes and symptomatic effects resulting from abstinence from alcohol. Used for both human and animal populations.", + "output": "Alcohol withdrawal syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Finding described as the process by which an infection is transmitted to a person.", + "output": "Transmission mode (Knowledge: Infection Management)" + }, + { + "input": "Definition: something described as hospital data management information systems designed to manage the assignment and status of caregiving locations such as inpatient hospital beds, emergency department rooms or \"hall beds,\" therapy bays in ancillary clinics (e.g., dialysis), and infusion chairs used in ambulatory infusion centers (e.g., chemotherapy clinics). These systems typically consist of a combination of hardware and software. The hardware typically includes dedicated network servers and computers; the software consists of a dedicated software package (e.g., bed-tracking) that is able to monitor bed status while actively tracking individual patient activity. This supportive documentation outlines the amount of time elapsed during each segment of the patient care process. It also provides immediate system notifications to housekeeping when a room has been vacated, allowing sufficient time to prepare and clean the bed and/or patient room. Bed management systems provide bed availability reports and real-time alerts, reduce patient wait times, and decrease emergency and/or other department overcrowding, allowing personnel to correctly match patients with the appropriate level of care. They may function as stand-alone systems or may be integrated in a hospital-wide data management information system network.", + "output": "Bed Data Management Systems (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a type 5 somatostatin receptor.", + "output": "type 5 somatostatin receptor binding (Molecular Function)" + }, + { + "input": "Definition: something described as the initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.", + "output": "vesicle tethering (cellular component organization)" + }, + { + "input": "Definition: something described as the growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.", + "output": "Bone development, NOS (Organ or Tissue Function)" + }, + { + "input": "Definition: Germinoma described as a term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors.", + "output": "Nonseminomatous germ cell tumor (Malignant germ cell neoplasm)" + }, + { + "input": "Definition: Genes, Regulator described as this gene may be involved in inflammation.", + "output": "MYLE (Genes, Regulator)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the superior portion of the uterus above the uterine tube line opposite to the cervix.", + "output": "Fundus uteri (Region of uterine body)" + }, + { + "input": "Definition: Natural Phenomenon or Process described as incorporation or addition of iodide in a compound.", + "output": "Iodation (Natural Phenomenon or Process)" + }, + { + "input": "Definition: something described as any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached.", + "output": "regulation of nematode larval development, heterochronic (Organism Function)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's current anxiety or depression.", + "output": "Feeling worried, sad or unhappy (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Systemic Chemotherapy Course Label described as the third chemotherapy course planned.", + "output": "Chemotherapy Course 3 (Systemic Chemotherapy Course Label)" + }, + { + "input": "Definition: CDK12 gene described as human CDK12 wild-type allele is located in the vicinity of 17q12 and is approximately 73 kb in length. This allele, which encodes cyclin-dependent kinase 12 protein, plays a role in the modulation of protein phosphorylation. Chromosomal deletions within the 17q12 region can lead to out of frame fusions of this gene and the ERBB2 gene and may be associated with gastric cancer.", + "output": "CRKRS (CDK12 gene)" + }, + { + "input": "Definition: Excessive tearing described as a form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct.", + "output": "Decreased tear drainage (Disease or Syndrome)" + }, + { + "input": "Definition: something described as catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.", + "output": "5-hydroxymethyluracil DNA N-glycosylase activity (Genetic Function)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as pathway structure of neuraxis which consists of corticospinal, corticobulbar, corticorubrospinal, corticoreticulospinal and corticotectospinal fibers.", + "output": "Corticospinal-corticobulbar pathway (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Meiosis described as the cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.", + "output": "Prophases (Meiosis)" + }, + { + "input": "Definition: negative regulation of cellular amide metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.", + "output": "down regulation of beta-amyloid formation (negative regulation of amyloid precursor protein catabolic process)" + }, + { + "input": "Definition: Stage I Testicular Non-Seminomatous Germ Cell Tumor AJCC v6 and v7 described as stage I includes: pT1-4, N0, M0, SX. pT1: Tumor limited to the testis and epididymis without vascular/lymphatic invasion; tumor may invade into the tunica albuginea but not the tunica vaginalis. pT2: Tumor limited to the testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis. pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion. pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. SX: Marker studies not available or not performed.", + "output": "Stage I Testicular Choriocarcinoma (Stage I Testicular Non-Seminomatous Germ Cell Tumor AJCC v6 and v7)" + }, + { + "input": "Definition: something described as diabetes Distress Scale for Partners of Adults with Type 1 Diabetes (PARTNER-DDS) During the past month, I have been: Feeling overwhelmed by the constant demands of my partner's diabetes.", + "output": "PARTNER-DDS - Overwhelmed by Constant Demands (PARTNER-DDS Questionnaire Question)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of carcinoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.", + "output": "Carcinoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Unit of Cell Concentration described as a unit of cell concentration expressed as the number of total cells per femur.", + "output": "Viable Cell per Femur (Unit of Cell Concentration)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as this polypeptide is comprised of the carboxy-terminal portions of procollagen, which are proteolytically removed by bone morphogenetic protein 1 during the intracellular formation of type I collagen fibrils. Increased plasma or serum concentrations of these peptides are associated with both fibrillogenesis of type I collagen and bone formation.", + "output": "Procollagen type I carboxy terminal peptide (collagen)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in kidney development.", + "output": "family with sequence similarity 123B (Gene or Genome)" + }, + { + "input": "Definition: SKIN, NAILS, HAIR described as a chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.", + "output": "Pyoderma fistulans significa (Chronic inflammatory disorder)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82653\" active clinical trials using this agent.", + "output": "Ixazomib Citrate (Substance with benzamide structure)" + }, + { + "input": "Definition: Progesterone Receptor Status described as describes cells that do not have a protein to which the hormone progesterone will bind. Cancer cells that are progesterone receptor negative do not need progesterone to grow, and usually do not stop growing when treated with hormones that block progesterone from binding.", + "output": "pr- (Laboratory or Test Result)" + }, + { + "input": "Definition: SPECIFIC SUBSTANCE CHEMISTRY TESTS described as the determination of the amount of homocitrulline present in a sample.", + "output": "Homocitrulline (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: something described as a collection of items and item groups for capturing and displaying clinical trial data.", + "output": "Manufactured form (Manufactured Object)" + }, + { + "input": "Definition: Lung Cancer Clinical TNM Finding v8 described as a clinical finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.", + "output": "Lung Cancer Clinical Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Theory described as examination of organizations, structures, or procedures from a macroscopic perspective that integrates constituent parts into a whole.", + "output": "system theory (Theory)" + }, + { + "input": "Definition: Anal Cancer Pathologic Primary Tumor TNM Finding v6 described as anal cancer with tumor size more than 2 centimeters, but 5 centimeters or less, in greatest dimension.", + "output": "Anal Canal Carcinoma pT2 TNM Finding v6 and v7 (Finding)" + }, + { + "input": "Definition: Abnormal cerebral morphology described as the presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain.", + "output": "Atrophy/Degeneration affecting the cerebrum (Pathologic Function)" + }, + { + "input": "Definition: something described as a plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.", + "output": "Blood Coagulation Factor II (Pharmacologic Substance)" + }, + { + "input": "Definition: Duodenal Hemorrhage, CTCAE 5 described as transfusion indicated; invasive intervention indicated; hospitalization", + "output": "Grade 3 Duodenal Hemorrhage, CTCAE (Finding)" + }, + { + "input": "Definition: something described as the protoplasm and plasma membrane of plant, fungal, bacterial or archaeon cells without the CELL WALL.", + "output": "protoplast (Biospecimen)" + }, + { + "input": "Definition: Cytokine Receptor Binding described as interacting selectively and non-covalently with the interleukin-9 receptor.", + "output": "Interleukin-9 receptor binding activity (growth factor receptor binding)" + }, + { + "input": "Definition: Qualitative Concept described as a relationship between a composite activity and a component activity that comprises it, i.e. parent and child activities where all activities are intended to occur at some point in the context of a particular study or experiment. EXAMPLE(S): A battery of tests may be composed of multiple routine labs that are always ordered together as a group. A glucose tolerance test which is comprised of administering glucose and taking multiple timed blood samples which are then tested for glucose. OTHER NAME(S): NOTE(S): This class helps represent an AND relationship between siblings with the same parent activity.", + "output": "Planned Composition Relationship (Qualitative Concept)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine.", + "output": "spermine:oxygen oxidoreductase (spermidine-forming) activity (oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor)" + }, + { + "input": "Definition: Cell described as the parent cells that give rise to both cells of the MEGAKARYOCYTE and the ERYTHROCYTE lineages.", + "output": "Megakaryocyte-Erythrocyte Progenitor (Myeloid Progenitor Cells)" + }, + { + "input": "Definition: Medical Device described as blood culture media used in manual assays consisting of a bottle that contains an agar slant partially immersed in a broth (biphasic media). These media, with appropriate ventilation, are also used for fungi cultures.", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media, Manual Test, Biphasic (Medical Device)" + }, + { + "input": "Definition: Strong acid described as an acid that contains phosphorus and is used in medicine and dentistry. It is also used to remove rust. A dilute form of phosphoric acid is used to flavor soft drinks.", + "output": "phosphoric acid (Phosphorus and phosphorus compound)" + }, + { + "input": "Definition: Disease Stage Qualifier described as a stage term that refers to a cancer in which the primary site is unknown (not detectable by clinical or radiologic examination). The definition of occult stage depends on the particular type of cancer that it refers to; for example, for breast cancer, occult stage is defined as cancer presenting with axillary lymph node metastasis without a primary in the breast being found; for non-small cell lung carcinoma, occult stage is defined as cancer detectable by sputum cytology only and the primary tumor is undetectable radiographically or during bronchoscopy.", + "output": "Occult Stage (Disease Stage Qualifier)" + }, + { + "input": "Definition: amino acid metabolism described as the modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.", + "output": "Acids Activation, Amino (Molecular Function)" + }, + { + "input": "Definition: Basal lamina described as a layer of the cerebral cortex that is of lesser visual density than the layers adjacent to it. The cell density is low, so it appears light in cell stains. A well known example is in the rostral entorhinal area, where the lamina rara is sometimes termed a separate layer and sometimes considered part of the layer superficial to it. The term was used by early cortical histologists but is not common today (J. Price, personal communication).", + "output": "Lamina lucida (Epithelium Part)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.", + "output": "exodeoxyribonuclease activity, producing 5' phosphomonoesters (Genetic Function)" + }, + { + "input": "Definition: something described as silica beads that are bound to octadecyl carbon chains and are used to fill columns as the stationary phase for a number of chromatography-based techniques.", + "output": "C18 Column (Research Device)" + }, + { + "input": "Definition: something described as this gene is involved in embryonic development and in the determination of cell fate.", + "output": "SRY (sex determining region Y)-box 2 (Gene or Genome)" + }, + { + "input": "Definition: Finding described as presence of xenobiotic in hair. []", + "output": "Hair xenobiotic (Finding)" + }, + { + "input": "Definition: Occupation or Discipline described as a class of professional or vocational positions of employment that involve protective services.", + "output": "Protective services (Occupation or Discipline)" + }, + { + "input": "Definition: something described as cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers. Mitotic figures are present in the basal two thirds of the epithelium.", + "output": "neoplasia; intraepithelial, cervix, grade II (Squamous intraepithelial neoplasia grade 2)" + }, + { + "input": "Definition: something described as potential for inadequate physiological activity of the gastrointestinal tract and organs causing discomfort or interference with the breaking down of food for absorption and elimination of wastes.", + "output": "At risk of impaired gastrointestinal system function (Physiologic Responses)" + }, + { + "input": "Definition: something described as the business of a regulatory agency.", + "output": "Regulatory Affairs (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Bullet-shaped proximal toe phalanx described as an abnormal morphology of the proximal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.", + "output": "Bullet-shaped innermost bone of pinkie toe (Bullet-shaped proximal toe phalanx)" + }, + { + "input": "Definition: Lymph node group described as a lymph node located in the sacral region.", + "output": "Sacral lymph node group (Lymph node group)" + }, + { + "input": "Definition: SF36 v1 0 Acute Questionnaire Question described as the Short Form 36 Health Survey Acute, Version 1.0 (SF36 v1.0 Acute) Question 3f.", + "output": "SF-36 v1.0 Acute - Question 3f (SF36 v1 0 Acute Questionnaire Question)" + }, + { + "input": "Definition: something described as a well differentiated, intermediate grade tumor with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.", + "output": "Esophageal Neuroendocrine Tumor G2 (Esophageal Neuroendocrine Tumor)" + }, + { + "input": "Definition: Congenital anomaly of ovary described as a gonad that contains both ovarian follicles and testicular tubular elements.", + "output": "congenital malformations ovotestis (Congenital fusion of testis)" + }, + { + "input": "Definition: 1st Generation/Typical described as organic heterocyclic compound used as a tranquilizing agent.", + "output": "Loxapina (L [Preparations])" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Children's Baseline/Screening - Most lethal attempt date.", + "output": "CSS07-Most Lethal Attempt Date (C-SSRS Children's Baseline/Screening Questionnaire Question)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation intended to be diluted in the specified liquid to obtain a suspension for injection.", + "output": "Concentrate for Suspension for Injection Dosage Form (CONCENTRATE FOR SOLUTION FOR INJECTION)" + }, + { + "input": "Definition: Vascular Endothelial Growth Factors described as a vascular endothelial growth factor expressed in a variety of tissues. It binds with high specificity to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 and NEUROPILIN-1.", + "output": "VEGF-B (Vascular Endothelial Growth Factors)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP.", + "output": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: Finding described as a retinal condition of very immature infants that may be characterized by non-vascularized retina that may lead to neovascularization, scarring, retinal detachment, and blindness.", + "output": "Retinopathy of Prematurity, AE (Finding)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Self-administered (WHODAS 2.0 12-item Version Self-administered) In the past 30 days, how much difficulty did you have in: Concentrating on doing something for ten minutes?", + "output": "WHODAS 2.0 12-item Version Self-administered - Concentrating for Ten Minutes (Intellectual Product)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.", + "output": "spermine synthesis (polyamine biosynthetic process)" + }, + { + "input": "Definition: Image View described as detector data acquired in a specified direction from the subject. It represents a view from a certain direction.", + "output": "Projection View (Image View)" + }, + { + "input": "Definition: Organic Chemical described as a class of tannins which are composed of two or more flavan-3-ol units with multiple hydroxyl groups.", + "output": "polyhydroxyflavan-3-ol (Plant product)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual was being so fidgety or restless that it seemed that one has been moving around more.", + "output": "Being so fidgety or restless that you have been moving around more (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as electroencephalographs (EEGs) designed for recording the variations of the electric potential caused by the electrical activity of the brain, usually detected on the scalp in ambulatory patients. These instruments consist of a main unit using an electronic storage device (tape recorders may be also used) worn by the patient that automatically process the signals and a cable that is connected at the distal tip to a set of electrodes fixed on the scalp in an array of standardized positions. The electrodes and leads transmit the bioelectrical signals to the recorder, usually through micro amplifiers. The recorder is capable of reproducing their characteristics in an amplitude versus time graph (i.e., an electroencephalogram) and may also provide a spectral analysis of the signals. Ambulatory EEGs, known as AEEGs, are mainly used for periods of 24 to 72 hours to confirm the diagnosis of epilepsy, assessment of seizures, and to record other neurological diseases.", + "output": "Electroencephalographs, Ambulatory (Standard EEG machine)" + }, + { + "input": "Definition: something described as a general term that refers to a TNM finding of cancer metastases in several regional lymph nodes. The definition of N2a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 4 to 9 axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm); for cutaneous melanoma it refers to micrometastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in 4-6 regional lymph nodes.", + "output": "N2a (N2 category)" + }, + { + "input": "Definition: something described as experimentally induced tumors of the LIVER.", + "output": "Experimental Liver Neoplasms (Neoplasms, Experimental)" + }, + { + "input": "Definition: Serous fluid described as the clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.", + "output": "fluid joints synovial (Body part)" + }, + { + "input": "Definition: Joint structure of shoulder girdle or upper limb described as the articulation between a metacarpal bone and a phalanx.", + "output": "joints mp (Joint by Site)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 487 of the coding sequence of the SDHB gene where thymine has been mutated to cytosine.", + "output": "SDHIP c.487T>C (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Immunoproteins described as proteins that bind to cytotoxic T-lymphocyte protein 4, which is expressed on T-cells, and stimulate signaling that may play a role in the inhibition of T-cell activation. This group of proteins includes the T-lymphocyte activation antigens CD80 and CD86, which are expressed on antigen-presenting cells.", + "output": "CTLA4 Ligand (Immunologic Factor)" + }, + { + "input": "Definition: BPRS 1988 Version Clinical Classification Question described as brief Psychiatric Rating Scale 1988 Version (BPRS 1988 Version) Conceptual disorganization.", + "output": "BPRS01-Conceptual Disorganization (BPRS 1988 Version Clinical Classification Question)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as intercellular adhesion molecule 3 (547 aa, ~60 kDa) is encoded by the human ICAM3 gene. This protein plays a role in both leukocyte adhesion and integrin binding.", + "output": "CDw50 antigen, human (Cell Adhesion Molecules)" + }, + { + "input": "Definition: Knowledge level: health promotion described as extent of understanding conveyed about labor and vaginal delivery", + "output": "Knowledge: Labor & Delivery (Finding)" + }, + { + "input": "Definition: negative regulation of protein-containing complex assembly described as any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization.", + "output": "down regulation of protein oligomerization (Cell Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic peripheral neuropathy with characteristics of early hypotonia evolving to spastic paraparesis, areflexia, decreased pain and temperature sensitivity, autonomic neuropathy, gastrooesophageal reflux disease, recurrent pneumonia and respiratory problems. Patients also have intellectual disability and dysmorphic features, including mild brachycephalic microcephaly, short broad neck, low anterior hairline and coarse face. Caused by homozygous mutation in the TECPR2 gene on chromosome 14q32.", + "output": "Autosomal recessive spastic paraplegia type 49 (Hereditary Sensory and Autonomic Neuropathies)" + }, + { + "input": "Definition: Homeopathic remedies letter F described as bromide of iron.", + "output": "ferrum bromatum/iron bromide (Inorganic Chemical)" + }, + { + "input": "Definition: Transcription Regulation Gene described as this gene is involved in cell cycle and transcriptional regulation.", + "output": "SPT3L (Transcription Regulation Gene)" + }, + { + "input": "Definition: something described as a type of radiation therapy that uses tiny particles called neutrons made by a machine called a cyclotron.", + "output": "therapy, high-LET neutron (Therapeutic radiology procedure)" + }, + { + "input": "Definition: antagonists & inhibitors described as any substance or agent which suppresses, prevents or opposes intracellular transport; use with specific agent being inhibited.", + "output": "transport inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: positive regulation of immune response described as any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.", + "output": "positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (Cell Function)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as chief cation of the extracellular body fluids.", + "output": "sodium cation (Element, Ion, or Isotope)" + }, + { + "input": "Definition: Anemia, Hemolytic, Congenital Nonspherocytic described as waters-West syndrome is characterised by the association of lethal non-spherocytic, non-immune haemolytic anaemia with abnormalities of the external genitalia (micropenis and hypospadias), flat occiput, dimpled earlobes, deep plantar creases, and increased space between the first and second toes. It has been described only once in two brothers who died a few hours after birth. The second-born infant had massive ascites and hepatosplenomegaly. The mother had two spontaneous abortions but gave birth to a normal girl, suggesting an autosomal or X-linked recessive mode of inheritance.", + "output": "Lethal hemolytic anemia and genital anomaly syndrome (Congenital anemia)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.", + "output": "cellular response to vitamin B6 (cellular response to drug)" + }, + { + "input": "Definition: something described as the length, in cm, of the shortest chorionic disc axis measured perpendicular to the larger axis.", + "output": "Shorter Diameter of Placenta (Placental finding)" + }, + { + "input": "Definition: something described as a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.", + "output": "1-methyl-d-tryptophan (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde.", + "output": "palmitaldehyde biosynthesis (hexadecanal metabolic process)" + }, + { + "input": "Definition: something described as a potency unit equal to the potency at which one milliliter of preparation contains one 50 percent cell culture infective dose.", + "output": "CCID 50/mL (Unit of Arbitrary Substance Concentration)" + }, + { + "input": "Definition: Congenital Abnormality described as a congenital abnormality characterized by the presence of a duplicated segment of the esophagus. The duplicated segment may by tubular or cystic.", + "output": "duplication; esophagus (Non-Neoplastic Esophageal Disorder)" + }, + { + "input": "Definition: Finding described as an adverse event in a newborn characterized by moderate irritability, minor changes in feeding and sleeping behavior, requiring minor additional care (e.g. occasional analgesics).", + "output": "Grade 2 Infant Irritability, AE (Finding)" + }, + { + "input": "Definition: Device Labeled for Single Use described as pouches in which a battery-powered portable telecommunication transmitter attached to an ambulatory patient may be carried. These pouches are typically plastic or fabric containers with appropriate means of attachment (e.g., a belt, a shoulder strap) to the patient. The transmitter in the pouch is connected to sensors (e.g., lead wires with electrodes for electrocardiography) on the patient's body and to a small antenna that transmits the signal to a remote receiving antenna. The antenna is linked to a central station monitor, where the patient's physiologic parameters are displayed. Telemetry pouches are used mainly in hospitals to facilitate physiologic parameter monitoring of patients who are not in critical condition but who require continuous monitoring.", + "output": "Pouches, Telemetry (Medical Device)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of response to butan-1-ol.", + "output": "up regulation of response to butan-1-ol (regulation of response to butan-1-ol)" + }, + { + "input": "Definition: HLA-G gene described as human HLA-G wild-type allele is located in the vicinity 6p21.3 and is approximately 4 kb in length. This allele, which encodes HLA class I histocompatibility antigen, alpha chain G protein, plays a role in MHC class I-mediated immune responses.", + "output": "HLA-G Histocompatibility Antigen, Class I, G Gene (HLA-G gene)" + }, + { + "input": "Definition: BACTERIA AND RICKETTSIAE described as any bacteria that is not assigned to the species level but can be assigned to the Mycobacterium genus level.", + "output": "Mycobacterium (living organism) (Aerobic Actinomycetes)" + }, + { + "input": "Definition: joint and bone dysplasias described as an autosomal dominant condition caused by mutation(s) in the COL1A1 gene encoding the collagen alpha-1(I) chain. This disease is an acute inflammatory condition of infancy that causes soft tissue swelling (mostly of chin/cheeks), bone thickening/widening (particularly of the mandible/clavicles/long bones), pain, and irritability. This disease generally resolves by the 3rd year of life, although some bony deformity may persist.", + "output": "INFANTILE CORTICAL HYPEROSTOSIS (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: positive regulation of cell cycle process described as any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.", + "output": "upregulation of sister chromatid cohesion (regulation of sister chromatid cohesion)" + }, + { + "input": "Definition: Organism Function described as the appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "output": "interleukin-9 production (Organism Function)" + }, + { + "input": "Definition: something described as a FIGO stage term that applies to gynecologic cancers. For cervical cancer, it refers to invasive cancer that is diagnosed microscopically only. The stromal invasion has a maximum depth of 3.00 mm and a horizontal spread of 7.00 mm or less; there is no FIGO stage IA1 for endometrial cancer.", + "output": "Stage IA1 (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate.", + "output": "UDP-MurNAc-pentapeptide:D-aspartate ligase activity (acid-ammonia (or amide) ligase activity)" + }, + { + "input": "Definition: Acquired partial lipodystrophy described as a rare acquired localised lipodystrophy disorder characterised by the eruption of tender occasionally painful, erythematous nodules and plaques, which enlarge radially and resolve into lipoatrophic lesions, often located in the upper and lower limbs. Histologically lesions are characterised by lipophagic lobular panniculitis and absence of vasculitis.", + "output": "Panniculitis induced localized lipodystrophy (Acquired partial lipodystrophy)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 8p", + "output": "8p21-p12 (Cell Component)" + }, + { + "input": "Definition: Retroviridae described as a genus of single-stranded, reverse-transcribing RNA retroviruses with type B or type C morphology. It is the genus to which the mouse mammary tumor virus (MMTV) belongs.", + "output": "Betaretrovirus (Virus)" + }, + { + "input": "Definition: Lactobacillus described as any bacterial organism that can be assigned to the species Lactobacillus vaginalis.", + "output": "Lactobacillus vaginalis (Bacterium)" + }, + { + "input": "Definition: Meningioma by Site described as a meningioma that affects the jugular foramen.", + "output": "Meningioma of Jugular Foramen (Jugular Foramen Neoplasm)" + }, + { + "input": "Definition: Intellectual Product described as a response indicating that an individual is in excellent mood unaffected by their cancer.", + "output": "My mood is excellent and unaffected by my cancer (Intellectual Product)" + }, + { + "input": "Definition: something described as a population of healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (DNTs), with potential immunomodulating and anti-leukemic activities. The DNTs are expanded ex vivo in order to enhance their tumor destroying potential. Upon administration of the allogeneic DNTs (DNT-UHN-1), the receptors NKG2-D type II integral membrane protein (KLRK1; NKG2D) and DNAX accessory molecule 1 (cluster of differentiation 226; CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby destroying the tumor cells. DNTs derived from peripheral blood of healthy donors appear to be effective against certain types of tumor cells, including leukemia cells, and do not attack normal hematopoietic cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis.", + "output": "allogeneic DNT cells (Cell)" + }, + { + "input": "Definition: antigen processing and presentation via MHC class Ib described as the process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.", + "output": "antigen processing and presentation of lipid antigen via MHC class Ib (antigen processing and presentation via MHC class Ib)" + }, + { + "input": "Definition: ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Naming task for object 2.", + "output": "CDISC ADAS-Cog - Naming Objects and Fingers: 2 (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity.", + "output": "downregulation of choline phosphatase activity (regulation of phospholipase D activity)" + }, + { + "input": "Definition: MEMORY AND DISTURBANCES OF MEMORY described as mental function underlying learning; one model specifies 4 phases: acquisition, retention, recall, and recognition.", + "output": "Memory function (Mental Processes)" + }, + { + "input": "Definition: something described as a radioimmunoconjugate consisting of 3F8, a murine anti-GD2 ganglioside monoclonal antibody labeled with iodine 131 (I-131), with radioimaging and radioimmunotherapeutic properties. Using monoclonal antibody 3F8 as a carrier for I-131 results in the targeted imaging and/or destruction of cells expressing GD2. GD2 is a ganglioside which is overexpressed in malignant melanoma, neuroblastoma, and small cell carcinoma of the lung. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2431\" active clinical trials using this agent.", + "output": "I 131 Monoclonal Antibody 3F8 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as either of two small, triangular, bilateral muscles located inferior the pectoralis major muscle, which originate from the third to fifth ribs near their costal cartilages and inserting on the medial border and superior surface of the coracoid process of the scapula, and which function to stabilize the scapula against the thoracic wall.", + "output": "pectoralis minor muscle (Medial rotator of scapula)" + }, + { + "input": "Definition: Structure of striated muscle described as muscle with fibers divided by transverse bands into striations; in general under voluntary control.", + "output": "Striated Muscles (Tissue)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 3 Months Version - These are questions about other effects that your respiratory problems may have on you these days: I have become frail or an invalid because of my respiratory problems.", + "output": "SGRQ01-I Have Become Frail (Intellectual Product)" + }, + { + "input": "Definition: Personal Attribute described as the period of light that a subject is exposed to in a period of time, usually expressed as the amount of time in a 24 hour cycle.", + "output": "Light Cycles (Temporal Concept)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as proinsulin (110 aa, ~12 kDa) is encoded by the human INS gene. This protein plays a role in the modulation of glucose metabolism.", + "output": "Insulin Precursor (INS Gene Product)" + }, + { + "input": "Definition: Superfamily Heterocheiloidea described as a species of parasitic nematode in the family Anisakidae. A. simplex is the causative agent of anisakiasis.", + "output": "Anisakis simplex (Superfamily Heterocheiloidea)" + }, + { + "input": "Definition: Medical Device described as systems designed for automated delivery of low levels of anesthetics to provide patient sedation and simultaneous monitoring of physiologic parameters during gastrointestinal endoscopic procedures performed in the lower (i.e., colonoscopy) and/or upper tract (i.e., esophago-gastroduodenoscopy also known as EGD). These systems typically consist of a module intended for anesthetic (e.g., propofol) and oxygen delivery, and monitors of patient's responsiveness, vital signs and other physiologic parameters such as oxygen saturation, end-tidal carbon dioxide, and electrocardiography. The quantity of drug administration and level of oxygen delivery are based on the results of computerized algorithms processing physiologic parameters data. The system includes controls to regulate the quantity of drug delivered and alarms (e.g., apnea, hypoxia, low respiratory rate). Gastrointestinal endoscopy automated sedation/monitoring systems are intended for use in routinely procedures performed by trained nurses without the presence of an anesthesiologist.", + "output": "Sedation/Physiologic Monitoring Systems, Gastrointestinal Endoscopy (Medical Device)" + }, + { + "input": "Definition: Reproductive tract neoplasms NEC described as a type of tumor that begins in the cells that give rise to sperm or eggs. Germ cell tumors can occur almost anywhere in the body and can be either benign or malignant.", + "output": "cells germ tumors (Reproductive tract neoplasms NEC)" + }, + { + "input": "Definition: something described as di long", + "output": "lumbricus/di long (Oriental herbs and natural substances letter L)" + }, + { + "input": "Definition: Individual Behavior described as an induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.", + "output": "Reaction, Cataleptic Immobilization (Behavior, Animal)" + }, + { + "input": "Definition: something described as a subjective response indicating that an individual uses or used one absorbent pad per day.", + "output": "1 pad per day (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.", + "output": "purine ribonucleotide breakdown (ribonucleotide catabolic process)" + }, + { + "input": "Definition: Cell Defense Process described as the process by which phagocytes engulf and digest microorganisms and cellular debris; an important defense against infection.", + "output": "Phagocytosis (Immunity, Innate)" + }, + { + "input": "Definition: Manufactured Object described as a transistor designed so that current through it is controlled by a variable electric field.", + "output": "Field Effect Transistor (Transistor Device)" + }, + { + "input": "Definition: regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway described as any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway.", + "output": "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen.", + "output": "anaerobic 2-aminobenzoate metabolism (anthranilate metabolic process)" + }, + { + "input": "Definition: Gene Therapy Agent described as a preparation composed of three separate DNA plasmids encoding the tumor-associated antigens (TAAs) Wilms tumor gene-1 (WT1), prostate-specific membrane antigen (PSMA) and human telomerase reverse transcriptase (hTERT), with potential immunostimulating and antineoplastic activites. Upon intramuscular delivery and electroporation of the WT1/PSMA/hTERT-encoding plasmid DNA INO-5401, the genes are translated into their respective proteins inside the cell. The expressed proteins activate the immune system and induce a cytotoxic T-lymphocyte (CTL)-mediated response against cells expressing the WT1, PSMA and hTERT antigens, causing tumor cell lysis. hTERT, WT1 and PSMA are upregulated in many cancer cell types.", + "output": "WT1/PSMA/hTERT-encoding Plasmid DNA INO-5401 (Biological Response Modifiers)" + }, + { + "input": "Definition: Mycobacterium species described as a complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.", + "output": "MAC (Genus Mycobacterium)" + }, + { + "input": "Definition: Nerve Sheath Tumors described as a rare neurofibroma characterized by the presence of melanin-laden cells and the absence of atypia.", + "output": "Pigmented neurofibroma (Benign Neoplasm)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the spastic paraplegia 3A, atlastin (SPG3A) gene, located at chromosome 14q22.1, which encodes for a protein that may be involved in axonal maintenance. This inherited genetic mutation has been identified in patients with spastic paraplegia type 3A.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SPG3A (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Food described as distributed worldwide, crustaceans are distinguished by having two pairs of antenna-like appendages in front of the mouth and other paired appendages near the mouth that act like jaws. Most species are marine, including shrimps and barnacles. Some, including crayfishes, live in freshwater habitats; others (e.g., sand fleas, land crabs, and sow bugs) live in moist terrestrial environments.", + "output": "Crustacean (Shellfish)" + }, + { + "input": "Definition: Neoplastic Process described as intraepithelial neoplasia involving the anal canal. The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).", + "output": "Low Grade Anal Canal Intraepithelial Neoplasia (Anal Canal Squamous Intraepithelial Neoplasia)" + }, + { + "input": "Definition: Acquired neutropenia described as a rare acquired immunodeficiency disease with characteristics of adult-onset absolute neutrophil counts less than 1.5 x 10^9/L on at least 3 occasions in a 3 month period that cannot be attributable to drugs or a specific genetic, infectious, inflammatory, autoimmune or malignant cause. Recurrent apthous stomatitis and a history of mild bacterial infections are typically associated. A benign outcome with a low rate of severe infections and no secondary malignancies is observed.", + "output": "Adult chronic idiopathic neutropenia (Acquired neutropenia)" + }, + { + "input": "Definition: nuclear retention of pre-mRNA at the site of transcription described as the process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription.", + "output": "nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription (Genetic Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in the transcriptional activation of target genes.", + "output": "MYCNOS (Gene or Genome)" + }, + { + "input": "Definition: something described as DNA ligase 1 (919 aa, ~102 kDa) is encoded by the human LIG1 gene. This protein plays a role in DNA replication and repair of nicks in double stranded DNA.", + "output": "Polydeoxyribonucleotide Synthase [ATP] 1 (Ligase)" + }, + { + "input": "Definition: something described as non-neoplastic macrophages that infiltrate a tumor.", + "output": "TIM (macrophage)" + }, + { + "input": "Definition: something described as an increase in the level of methylsuccinic acid in the urine.", + "output": "Increased level of pyrotartaric acid in urine (Finding)" + }, + { + "input": "Definition: Equipment and Supplies described as apparatus for removing exhaled or leaked anesthetic gases or other volatile agents, thus reducing the exposure of operating room personnel to such agents, as well as preventing the buildup of potentially explosive mixtures in operating rooms or laboratories.", + "output": "Scavenger, Gas (Medical Device)" + }, + { + "input": "Definition: something described as cathepsin L1 (333 aa, ~38 kDa) is encoded by the human CTSL gene. This protein is involved in both proteolysis and immunity.", + "output": "cathepsin L (Enzyme)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of response to calcium ion.", + "output": "regulation of response to calcium ion (Physiologic Function)" + }, + { + "input": "Definition: something described as a course of food intake prescribed for patients, that limits the amount of foods with a high GLYCEMIC INDEX.", + "output": "Diabetes--Diet therapy (Food and Nutrition)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a protocol for induction of moderate psychological stress in a laboratory setting and for evaluating its effects on physiological responses. It mainly consists of a 10 minute anticipation period, followed by a 10 minute test period during which the subject has to deliver a free speech and perform mental arithmetic in front of an audience. This protocol has been found to induce changes in the concentration of adrenocorticotropic hormone, cortisol (serum and saliva), somatotropin, and prolactin, as well as significant increases in heart rate.", + "output": "Tests, Trier Stress (Intellectual Product)" + }, + { + "input": "Definition: Anatomical Abnormality described as a structural anomaly of a male reproductive cell.", + "output": "Abnormal male germ cell morphology (Anatomical Abnormality)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+).", + "output": "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: VFQ25-Interviewer Administered Format Questionnaire Question described as visual Functioning Questionnaire 25-Interviewer Administered Format Version 2000 (VFQ25-Interviewer Administered Format) Responses to Vision Problems: I need a lot of help from others because of my eyesight.", + "output": "VFQ124 (VFQ25-Interviewer Administered Format Questionnaire Question)" + }, + { + "input": "Definition: Unresectable Soft Tissue Sarcoma described as rhabdomyosarcoma which is not amenable to surgical resection.", + "output": "Unresectable Rhabdomyosarcoma (Unresectable Soft Tissue Sarcoma)" + }, + { + "input": "Definition: Vaginal Cancer TNM Finding v8 described as a clinical finding about one or more characteristics of vaginal cancer, following the rules of the TNM AJCC v8 classification system.", + "output": "Vaginal Cancer Clinical TNM Finding v8 (Vaginal Cancer TNM Finding v8)" + }, + { + "input": "Definition: Restrictive Cardiomyopathy, CTCAE described as refractory heart failure or other poorly controlled cardiac symptoms", + "output": "Grade 4 Restrictive Cardiomyopathy, CTCAE (Restrictive Cardiomyopathy, CTCAE)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization.", + "output": "mitochondrial localization by microtubule attachment (establishment of mitochondrion localization, microtubule-mediated)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a type of large, coiled, tubular, sometimes branched, specialized sweat gland that empties into the upper portion of a hair follicle instead of directly onto the skin surface. It has no secretory innervation but is sensitive to epinephrine in the bloodstream.", + "output": "apocrine glands sweat (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Colon Carcinoma described as a rare epithelial tumor of the colon arising from squamous cells of the colorectal epithelium without the presence of squamous-lined fistulous tracts or a proximal extension of an anal squamous cell carcinoma. It usually presents with nonspecific symptoms, such as anorexia, weight loss, abdominal pain, changes of bowel habits, hematochezia or melena. Cases of severe symptomatic hypercalcemia have been reported.", + "output": "large intestine malignant carcinoma of colon squamous cell (Neoplastic Process)" + }, + { + "input": "Definition: something described as the total area of a tissue sample.", + "output": "total tissue area (Spatial Concept)" + }, + { + "input": "Definition: Quantitative Concept described as a dosing measurement based on the patch unit.", + "output": "{PATCH} (Potency Unit)" + }, + { + "input": "Definition: Menispermaceae described as a plant genus of the family MENISPERMACEAE. Members contain dauricine and other ALKALOIDS.", + "output": "Menispermum, NOS (Plant)" + }, + { + "input": "Definition: Anti-PD-L1 Monoclonal Antibody described as a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-L1 monoclonal antibody GR1405 specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells.", + "output": "GR1405 (Immunologic Factor)" + }, + { + "input": "Definition: extracellular ligand-gated ion channel activity described as enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts.", + "output": "extracellular ammonia-gated ion channel activity (Molecular Function)" + }, + { + "input": "Definition: Laboratory or Test Result described as a dental health survey developed to evaluate a patient's orthodontic treatment need and priority for orthodontic care. The index is based on an assessment of degree of MALOCCLUSION and the potential aesthetic and dental health benefit of the treatment under consideration.", + "output": "Index of Orthodontic Treatment Need (Laboratory or Test Result)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) These are questions about other effects that your respiratory problems may have on you these days: Exercise is not safe for me.", + "output": "SGRQ Past 3 Months Version - Exercise Is Not Safe for Me (Intellectual Product)" + }, + { + "input": "Definition: something described as molecules generated from the metabolism of dopamine.", + "output": "Dopamine Metabolites (Metabolite)" + }, + { + "input": "Definition: Organic Chemical described as the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.", + "output": "ANCITABINE HYDROCHLORIDE (Organic Chemical)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of vemurafenib and cobimetinib that can be used for the treatment of melanoma.", + "output": "Cobimetinib/Vemurafenib Regimen (Regimen Used to Treat Melanoma)" + }, + { + "input": "Definition: Pharmacologic Substance described as opium, dried latex of poppy.", + "output": "opium poppy, homeopathic drug (Organic Chemical)" + }, + { + "input": "Definition: N [Preparations] described as the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. The mechanism of action through which nefopam exerts its analgesic effects is, as of yet, largely unknown but may involve inhibition of serotonin, dopamine and noradrenaline reuptake.", + "output": "3,4,5,6-tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Learning a new task, for example, learning how to get to a new place?", + "output": "WHODAS 2.0 12-item Version Interviewer-administered - Learning a New Task (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate.", + "output": "taxis in response to electron acceptor (Cell Function)" + }, + { + "input": "Definition: Cells described as sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.", + "output": "Hair Cell (Teloreceptor)" + }, + { + "input": "Definition: something described as a process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus.", + "output": "replication fork arrest at mating type locus (Genetic Function)" + }, + { + "input": "Definition: biochemical test described as a measurement of the neurotensin in a biological specimen.", + "output": "NTS (Chemical procedure)" + }, + { + "input": "Definition: Device Component or Accessory described as a device to hold an amount of film and facilitate its loading into a device.", + "output": "Film Cartridge Device (Device Component or Accessory)" + }, + { + "input": "Definition: Functional Concept described as defined rules, conventions, guidelines, characteristics, methods, formats, and terminologies that provide structure and consistency for exchange and utilization of data. NOTE: Data standards may describe the elements and relationships necessary to achieve the unambiguous exchange of data between disparate information systems. [After https://www.fda.gov/media/124694/download Standards Development and the Use of Standards in Regulatory Submissions Reviewed in the Center for Biologics Evaluation and Research Guidance for Industry MARCH2019, NCI Thesaurus]. See also interoperability, standard, CDISC standards, Study Data Standardization Plan, and Standards Development Organization.", + "output": "EXTRAP (Functional Concept)" + }, + { + "input": "Definition: Substance-Related Disorders described as a psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to substance use, intoxication or withdrawal.", + "output": "Psychotic disorder caused by substance (Schizophrenia and other psychotic disorders)" + }, + { + "input": "Definition: Ciliated columnar epithelium described as the epithelium of the bronchioles of the lung, which consists of cuboidal cells.", + "output": "Bronchiole Epithelium (Ciliated columnar epithelium)" + }, + { + "input": "Definition: Biomedical or Dental Material described as sterile lyophilisate and sterile solvent intended for the preparation of a suspension for injection, for veterinary use, by dispersing the lyophilisate in the solvent.", + "output": "Lyophilisate and Solvent for Suspension for Injection Dosage Form (Combined Dosage Form)" + }, + { + "input": "Definition: something described as a question about products not previously mentioned or specified that an individual used in the past 30 days to quit or stay off smoking cigarettes.", + "output": "What other products have you used to quit (or to stay off) smoking cigarettes (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of opioid receptor signaling pathway.", + "output": "regulation of opioid receptor signalling pathway (regulation of G protein-coupled receptor signaling pathway)" + }, + { + "input": "Definition: Molecular Function described as a series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.", + "output": "calcium-dependent activation of phospholipase A2 (Molecular Function)" + }, + { + "input": "Definition: something described as an inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4.", + "output": "Famil dysalb hyperthyroxinaem (Hyperthyroxinemia)" + }, + { + "input": "Definition: something described as endothelin-1 (212 aa, ~24 kDa) is encoded by the human EDN1 gene. This protein is involved in vasoconstriction.", + "output": "PPET1 (peptide hormone)" + }, + { + "input": "Definition: something described as using acridine orange, this technique produces a chromosomal staining pattern which is the reverse of G-banding.", + "output": "R-Banding (Laboratory Procedure)" + }, + { + "input": "Definition: Region of parietal cortex described as a composite structure of the cerebral cortex in the rat. It consists of area SI of Woolsey and area SII of Woolsey ( Swanson-2004 ).", + "output": "Somaesthetic area (Region of parietal cortex)" + }, + { + "input": "Definition: Campylobacter described as any bacterial organism that can be assigned to the species Campylobacter curvus.", + "output": "Campylobacter curvus (Bacterium)" + }, + { + "input": "Definition: Pigmentation described as the color of the iris of the eye.", + "output": "eye color (Ocular Physiological Phenomena)" + }, + { + "input": "Definition: something described as an indication that expression of ligands for the killer-cell immunoglobulin-like receptors have not been detected in a sample.", + "output": "KIR Ligand Negative (Expression Negative)" + }, + { + "input": "Definition: Sarcoma described as a variety of rare sarcoma having a reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue. It is a rare tumor, usually occurring between 15 and 35 years of age. It appears in the muscles of the extremities in adults and most commonly in the head and neck regions of children. Though slow-growing, it commonly metastasizes to the lungs, brain, bones, and lymph nodes.", + "output": "alveolar soft part sarcoma (Sarcoma)" + }, + { + "input": "Definition: Stage III Carcinoma of Penis described as stage IIIB includes: T1-3, N2, M0. T1: Tumor invades subepithelial connective tissue without lymph vascular invasion and is not poorly differentiated (i.e., grade 3-4) or tumor invades subepithelial connective tissue with lymph vascular invasion or is poorly differentiated. T2: Tumor invades corpus spongiosum or cavernosum. T3: Tumor invades urethra. cN2: Palpable mobile multiple or bilateral inguinal lymph nodes. pN2: Metastasis in multiple or bilateral superficial inguinal lymph nodes. M0: No distant metastasis. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88105\" active clinical trials using this agent.", + "output": "stage IIIB penile cancer (Stage III Carcinoma of Penis)" + }, + { + "input": "Definition: soft tissue injury of foot described as general or unspecified injuries involving the foot.", + "output": "wound; foot (Injury of lower leg)" + }, + { + "input": "Definition: Exercisers, Continuous Passive Motion, Upper Limb described as upper-limb continuous passive motion exercisers designed to provide controlled movements (flexion, extension, adduction, and/or rotation) to the shoulder joint without the patient's muscular exertion. These exercisers are typically an electronically controlled electromechanism that is attached to the patient's arm to provide periodic, rhythmic movements through a range of motion; they are intended to prevent joint stiffness in the shoulder. Shoulder continuous passive motion exercisers are used for physical therapy and rehabilitation after illness, trauma, and/or surgical treatment.", + "output": "Shoulder CPM Machines (Exercisers, Continuous Passive Motion, Upper Limb)" + }, + { + "input": "Definition: Medical Device described as gamma radiation detection probes designed to detect the level of radiation in the abdominal cavity around a cancer tumor after prior ingestion or injection of a radiopharmaceutical tracer (i.e., radioactive drug). These probes typically consist of a detector, a collimator, and shielding from radiation outside the intended target; they are used with imaging or non-imaging gamma radiation devices that display the count rate corresponding to each tissue. Abdominal gamma radiation probes are intended to detect high-radiation points (hot spots), facilitating to find the lymph node to which the tumor drains (sentinel node, SN), helping in the diagnosis and prognosis and detection of small cancer tumors and also in procedures used to identify small malignant (e.g., gastrointestinal, prostatic) lesions intra-operatively during open and laparoscopic surgery.", + "output": "Abdominal Radiation Detection Probes, Gamma (Medical Device)" + }, + { + "input": "Definition: Set of organ components of kidney described as the functional part of the kidney, comprising the renal cortex and medulla.", + "output": "kidneys parenchyma (Organ parenchyma)" + }, + { + "input": "Definition: Educational Activity described as formal graduate program leading to a medical degree; involves internship and residency programs leading to a profession in medicine and/or research.", + "output": "MED EDUC (Curricula)" + }, + { + "input": "Definition: Medical Device described as reagents intended to establish points of reference in immunoassay tests performed to determine either one or more of the group of substances that are safely and almost completely metabolized by the liver. These reagents may be either specific for calibration of a liver metabolic product or, more frequently, appropriate to calibrate a whole set of similar liver metabolic products.", + "output": "IVD Test Reagent/Kits, Immunoassay, Calibration, Liver Metabolism (IVD Test Reagent/Kits, Immunoassay, Calibration)" + }, + { + "input": "Definition: Pharmacologic Substance described as a powder for an oral solution comprised of the hydrochloride salt of 5-aminolevulinic acid (ALA) with a potential application for photodynamic therapy. After oral administration, ALA is converted intracellularly into the photosensitizer protoporphyrin IX (PpIX). Upon exposure to light of appropriate wavelength (violet to blue range), excited PpIX emits a characteristic red fluorescence which could facilitate guided resection, and generates excited singlet oxygen molecules that could kill cells when appropriate laser dosage is applied. ALA is preferentially taken up by and accumulates in many types of cancer cells compared to normal, healthy cells. Consequently, cancer cells can be visualized and can be distinguished from normal, healthy cells.", + "output": "Oral ALA HCl (Organic Chemical)" + }, + { + "input": "Definition: Anatomical Abnormality described as decreased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of a normal helix.", + "output": "Antihelix, stem, underdeveloped (Anatomical Abnormality)" + }, + { + "input": "Definition: Clinical Enzyme Tests described as the determination of the lipoprotein associated phospholipase A2 present in a sample.", + "output": "Lipoprotein Associated Phospholipase A2 (Laboratory Procedure)" + }, + { + "input": "Definition: something described as nodal myocyte which consists of the transitional and purkinje myocytes of the atrioventricular node", + "output": "Atrioventricular node myocyte (Cell)" + }, + { + "input": "Definition: Neoplastic Process described as a sebaceous carcinoma that arises from the skin in the head and neck.", + "output": "Head and Neck Sebaceous Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as protein MB21D2 (491 aa, ~56 kDa) is encoded by the human MB21D2 gene. This protein may play a role in cadherin-dependent cell-cell adhesion.", + "output": "Protein MB21D2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Organic Chemical described as sea serpent.", + "output": "Hydrophis cyanocinctus / sea serpent (Organic Chemical)" + }, + { + "input": "Definition: something described as an indication that an individual used something prior to their baseline visit.", + "output": "Use Before Visit (Clinical Observation)" + }, + { + "input": "Definition: something described as a temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual. []", + "output": "Abnormal temper tantrums (Abnormal behavior)" + }, + { + "input": "Definition: Molecular Function described as the formation of a linkage between a protein amino acid and pyridoxal-5-phosphate.", + "output": "protein-pyridoxal-5-phosphate linkage (protein-cofactor linkage)" + }, + { + "input": "Definition: Virus Diseases described as INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).", + "output": "Hepatitis, Viral, Human (Virus Diseases)" + }, + { + "input": "Definition: sensory organ development described as human Eye Development involves bilateral outpouchings of optic vesicles, from the neural tube, that each form optic cups. By cell division, migration, differentiation, and synaptogenesis, the inner surface becomes the multi-layer neuroepithelial retina; the outer monolayer becomes the retinal pigment epithelium. Surface membranes cover the eye and develop into the lens, iris and cornea.", + "output": "Eye Development (Histogenic Process)" + }, + { + "input": "Definition: Hematologic Tests described as a measurement of the hemosiderin complex in a biological specimen.", + "output": "Hemosiderin Measurement (Hematologic Tests)" + }, + { + "input": "Definition: Pharmacologic Substance described as cinnamon.", + "output": "Cinnamomum zeylanicum (Oils, Volatile)" + }, + { + "input": "Definition: Disease or Syndrome described as subtype of diabetes mellitus that is characterized by insulin deficiency; it is manifested by the sudden onset of severe hyperglycemia, rapid progression to diabetic ketoacidosis, and death unless treated with insulin; the disease may occur at any age, but is most common in childhood or adolescence.", + "output": "INSULIN-DEPENDENT DIABETES MELLITUS 1 (Endocrine system)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in endosomal vesicle fusion, extra-osseous calcification and inflammatory responses.", + "output": "FLJ20073 (Genes, Regulator)" + }, + { + "input": "Definition: Neoplastic Process described as stage II includes: IIA (T3, N0, M0); IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa or into the nonperitonealized perimuscular tissue (mesentery or retroperitoneum) with extension 2 cm or less. T4: Tumor perforates the visceral peritoneum or directly invades other organs or structures (including other loops of small intestine, mesentery, or retroperitoneum more than 2 cm, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Small Intestine Cancer Stage II (Small Intestinal Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O.", + "output": "alpha-humulene 10-hydroxylase activity (Molecular Function)" + }, + { + "input": "Definition: Bacterium described as a kind of bacteria that frequently causes lung, urinary tract, intestinal, and wound infections", + "output": "Klebsiella (Klebsiella)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a group of nuclei in the pontine tegmentum that contribute fibers to the facial nerve. They include the facial nucleus and the superior salivatory nucleus ( Carpenter-1983 ).", + "output": "facial nerve nuclei (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as the parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability.", + "output": "Estradiol Valeriante (Estranes)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - If yes, which best describes how {S} usually performed.", + "output": "ADL0211A (ADCS-ADL Severe Dementia Questionnaire Question)" + }, + { + "input": "Definition: something described as human ST7 wild-type allele is located within 7q31.1-q31.3 and is approximately 277 kb in length. This allele, which encodes suppressor of tumorigenicity 7 protein, is involved in remodeling of the extracellular matrix and may inhibit tumor growth via modification of the tumor microenvironment.", + "output": "TSG7 (ST7 gene)" + }, + { + "input": "Definition: hormone catabolic process described as the chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.", + "output": "pheromone breakdown (Organism Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an immunoglobulins A, G, M, D, and E immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the immunoglobulins A, G, M, D, an E (serum antibodies) in serum. Measurement of these immunoglobulins aids in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents.", + "output": "IGG, PEROXIDASE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Reproductive function described as the fusion of a spermatozoon (SPERMATOZOA) with an OVUM thus resulting in the formation of a ZYGOTE.", + "output": "Fertilization, NOS (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a fiber pathway in the cerebral white matter. It is not readily distinguished in myelin-stained cross-sections ( Carpenter-1983 ).", + "output": "external sagittal stratum (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as an out-pocket of thickened ventral foregut that develops approximately during the 4th week of embryonic development, and gives rise to the liver, gallbladder, and biliary duct system.", + "output": "Hepatic Diverticulum (Other Embryologic Structure)" + }, + { + "input": "Definition: something described as a critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.", + "output": "CD8-Positive T-Lymphocytes (Cell)" + }, + { + "input": "Definition: something described as a lesion having the shape of a mushroom.", + "output": "Mushroom-Shaped Lesion (Lesion)" + }, + { + "input": "Definition: PASAT Functional Test Question described as paced Auditory Serial Addition Test (PASAT) Percent correct.", + "output": "PASAT102 (PASAT Functional Test Question)" + }, + { + "input": "Definition: Homeopathic remedies letter P described as head louse.", + "output": "Pediculus capitis, Homeopathic preparation (Homeopathic remedies letter P)" + }, + { + "input": "Definition: something described as picomoles per liter (concentration), divided by meters squared (surface area).", + "output": "Picomole per Liter per Meter Squared (Quantitative Concept)" + }, + { + "input": "Definition: Family described as interventions to facilitate family unit functioning and promote the health and welfare of family members throughout the lifespan", + "output": "Lifespan Care (Family)" + }, + { + "input": "Definition: something described as a data type that is an abstract generalization for all value data types that have an order relationship.", + "output": "Quantity Data Type (DataType)" + }, + { + "input": "Definition: Chromosomal translocation described as a cytogenetic abnormality that involves a translocation between 8q22 and 21q22. It is associated with the development of acute myeloid leukemia with RUNX1-RUNX1T1 fusion protein expression.", + "output": "t(8;21)(q22;q22) (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a coded value specifying when this event started with respect to the sponsor-defined reference period. EXAMPLE(S): Medications that are ongoing at the end of the reference period should have a value of \"during/after\" for this variable. Before, during, during/after, after OTHER NAME(S): NOTE(S): Derived from comparing PerformedSubstanceAdministration.dateRange(IVL3< fraction (Enzyme)" + }, + { + "input": "Definition: Drug allergens described as a synthetic opioid analgesic. Dihydrocodeine bitartrate mimics the actions of the endogenous opioid peptides due to its agonistic effects on the opioid receptors. Stimulation of the mu receptors produces the typical narcotic effects of analgesia, miosis, euphoria, respiratory depression, sedation, physical dependence and bradycardia. Dihydrocodeine bitartrate is twice as potent as codeine and has one third of the potency of morphine. This analgesic is used for the relief of moderate to moderately severe pain.", + "output": "Dihydrocodeine Bitartrate (Opioid Receptor Agonist)" + }, + { + "input": "Definition: Surgical Endoscopy described as a procedure via an endoscope that is done to treat a condition.", + "output": "therapeutic endoscopic procedure (Endoscopy)" + }, + { + "input": "Definition: Medical Device described as thoracic orthoses designed to encircle the thorax to provide support to the muscles and bones and to keep the anterior part of the thorax in appropriate position. These devices may consist of wide pieces of elastic fabric or narrow strips of flexible materials (e.g., belts) available in several sizes; the orthoses are usually reinforced with metallic stays for appropriate support of the muscles and thoracic bones. Thoracic support orthoses are used mainly to support and compress the chest muscles, sternum, ribs, and/or other chest anatomical structures during rehabilitation from traumatic injuries (e.g., bone fracture) and/or to provide relief from pain and strain.", + "output": "Orthoses, Thoracic, Support (Medical Device)" + }, + { + "input": "Definition: Finding described as the heavy chain, IgM, of the immunoglobulin is defective. This finding is seen in other lymphocytic/plasmacytic disorders as well, including Waldenstrom macroglobulinemia.", + "output": "Multiple Myeloma-IgM (Plasma Cell Neoplasm Finding)" + }, + { + "input": "Definition: Physical shape described as a lymphocytic inflammation of the uteroplacental vessels.", + "output": "Chronic Uteroplacental Vasculitis (Placental finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).", + "output": "CAPEEE (Pharmacologic Substance)" + }, + { + "input": "Definition: Languages described as a system of hand gestures used for communication by the deaf or by people speaking different languages.", + "output": "Language, Sign (language)" + }, + { + "input": "Definition: Intellectual Product described as roland Morris Disability Questionnaire (RDQ) I walk more slowly than usual because of my back.", + "output": "RDQ0103 (RDQ Questionnaire Question)" + }, + { + "input": "Definition: Histone antibody Assay described as the determination of the amount of histone 3 antibody present in a sample.", + "output": "Histone 3 Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: PDGFR Inhibitor described as a drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.", + "output": "Product containing pazopanib (Enzyme Inhibitors)" + }, + { + "input": "Definition: something described as stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.", + "output": "ARF guanyl-nucleotide exchange factor activity (guanyl-nucleotide exchange factor activity)" + }, + { + "input": "Definition: Global Response in Viscera described as liver or spleen or any organ considered involved at baseline should not be enlarged on physical exam and should be considered normal by imaging; no nodules should be present on imaging of liver or spleen; any post treatment mass must be determined by biopsy to be negative for lymphoma.", + "output": "Viscera Complete Response (Finding)" + }, + { + "input": "Definition: Allergen class described as a class of dietary fatty acids with the first double bond at the 3rd carbon from the methyl end.", + "output": "n-3 fatty acids (Allergen class)" + }, + { + "input": "Definition: Clinical diagnostic instrument described as a blood pressure cuff is a device that has an inflatable bladder in an inelastic sleeve (cuff) with a mechanism for inflating and deflating the bladder. The cuff is used in conjunction with another device to determine a subject's blood pressure.", + "output": "Blood pressure cuff, device (Medical Devices)" + }, + { + "input": "Definition: something described as hyperthyroidism due to a condition originating within the hypothalamic-pituitary axis.", + "output": "Central Hyperthyroidism (Disease or Syndrome)" + }, + { + "input": "Definition: Chemical categorized by structure described as substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.", + "output": "Chemical Elements (Element, Ion, or Isotope)" + }, + { + "input": "Definition: Foot Deformities described as a condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet.", + "output": "Foot ectrodactyly (Lower Extremity Deformities, Congenital)" + }, + { + "input": "Definition: something described as an oral nutritional supplement, containing substantial amounts of polyunsaturated fatty acids, arginine, and nucleotides, with potential immunostimulating activity. Omega-3 fatty acids/arginine/nucleotides oral supplement may enhance activities of key components of the immune system, including lymphocytes, antigen presenting cells (APCs), and various cytokines. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62534\" active clinical trials using this agent.", + "output": "Arginine/Omega-3 Fatty Acids/Nucleotides Oral Supplement (Dietary Supplements)" + }, + { + "input": "Definition: Health Care Activity described as monitoring and manipulation of the physical environment to decrease the potential for violent behavior directed toward self, others, or environment", + "output": "Environmental Management: Violence Prevention (Environmental care procedure)" + }, + { + "input": "Definition: ATOPIC AND HYPERSENSITIVITY STATES described as an increased reactivity to specific antigens mediated not by antibodies but by cells.", + "output": "Delayed Hypersensitivity Reaction (Pathologic Function)" + }, + { + "input": "Definition: something described as reagents and techniques used for the diagnosis of cancer.", + "output": "Diagnostics, Cancer (Reagent Kits, Diagnostic)" + }, + { + "input": "Definition: Squamous cell carcinoma described as a cancer that originates in the squamous cells that line the surface of the vulva.", + "output": "SCC - Squamous cell carcinoma of vulva (Malignant neoplasm of vulva)" + }, + { + "input": "Definition: Anatomical Abnormality described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 5th toe.", + "output": "Speckled calcifications in end part of the innermost bone of the pinkie toe (Abnormality of the epiphysis of the middle phalanx of the 5th toe)" + }, + { + "input": "Definition: Manufactured Object described as institutions which provide medical or health-related services.", + "output": "Health care facilities (Health System)" + }, + { + "input": "Definition: Consortium or Network described as network of medical centers that will evaluate promising treatments for children with brain malignancies.", + "output": "Pediatric Brain Tumor Consortium (Consortium or Network)" + }, + { + "input": "Definition: Disease or Syndrome described as condition in which there is a deviation from or interruption of the normal reflexes; abnormal involuntary movements in response to a stimulus applied to the periphery.", + "output": "disorder; reflex (Disease or Syndrome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as nonEC; a ubiquitous group of protein serine/threonine kinases involved in many cellular functions, assayed by their ability to phosphorylate casein in vitro.", + "output": "Kinase, Casein (Intracellular Signaling Peptides and Proteins)" + }, + { + "input": "Definition: Malignant tumor of exocrine pancreas described as a disease in which malignant (cancer) cells are found in the tissues of the pancreas.", + "output": "pancreas carcinoma (Primary malignant neoplasm of pancreas)" + }, + { + "input": "Definition: Gene or Genome described as human GRK2 wild-type allele is located in the vicinity of 11q13.2 and is approximately 20 kb in length. This allele, which encodes beta-adrenergic receptor kinase 1 protein, is involved in the phosphorylation of beta-adrenergic and related G protein-coupled receptors.", + "output": "ADRBK1 (Gene or Genome)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as a selective effector cell activator protein and agonist of the intermediate-affinity interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic activity. Upon administration, intermediate-affinity interleukin-2 receptor agonist ALKS 4230 binds to and signals through the intermediate-affinity IL-2 receptor complex; this may selectively stimulate and activate natural killer (NK) cells and memory CD8 T cells, leading to tumor cell elimination, while circumventing the activation of immunosuppressive cells that may prevent the anti-tumor response. IL-2 is a cytokine signaling molecule that plays a critical role in the immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C128107\" active clinical trials using this agent.", + "output": "intermediate-affinity IL-2R agonist ALKS 4230 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a modified version of vitamin D binding protein (VDBP; Gc protein) macrophage activator, with potential antineoplastic and anti-angiogenic activities. Upon administration, modified VDBP-macrophage activator EF-022, acting in a similar manner as VDBP-macrophage activating factor (GcMAF), is able to activate tumoricidal macrophages, thereby enhancing the killing and eradication of cancer cells. In addition, EF-022 may inhibit tumor cell proliferation, migration and angiogenesis. VDBP is a glycoprotein and precursor for macrophage activating factor (MAF), which promotes macrophage activation; however VDBP can be deglycosylated by serum alpha-N-acetylgalactosaminidase, which is secreted from cancerous cells, and cannot be converted to MAF. Thus, the macrophage activation cascade is often impaired in tumor cells and plays a key role in tumor immunosuppression. Modification of VDBP stabilizes MAF.", + "output": "Modified Vitamin D Binding Protein Macrophage Activator EF-022 (Antineoplastic Agents)" + }, + { + "input": "Definition: Neoplasms by Site described as a benign or malignant, primary or metastatic neoplasm that affects the peritoneum and/or retroperitoneum.", + "output": "Peritoneal and Retroperitoneal Tumor (Neoplasms by Site)" + }, + { + "input": "Definition: something described as the component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", + "output": "extrinsic component of omegasome membrane (extrinsic component of organelle membrane)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of parathyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.", + "output": "Parathyroid Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 (Parathyroid Carcinoma Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Organism Function described as the process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.", + "output": "circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus (Organism Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a tumor-associated antigen immunological test system is a device that consists of reagents used to qualitatively or quantitatively measure, by immunochemical techniques, tumor-associated antigens in serum, plasma, urine, or other body fluids.", + "output": "Reagents, Immunoassay, Tumor Marker, Enzyme, Prostate Specific Antigen (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Brazilian State described as a state in the North Region of Brazil. Its capital is Belem.", + "output": "Para (Brazilian State)" + }, + { + "input": "Definition: Statistical Theory & Experimentation described as conceptually broad term that refers generally to strategies, techniques, or procedures used in applied, descriptive, or empirical studies. Compare EXPERIMENTAL METHODS.", + "output": "Methodology (Conceptual Entity)" + }, + { + "input": "Definition: something described as a unit of fraction expressed as the ratio of the amount of a substance in solution, in millimoles, to the amount of a different substance in the mixture, in moles.", + "output": "mmol/mol (Unit of Mole Fraction)" + }, + { + "input": "Definition: CYP2C19 gene described as human CYP2C19*3 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*3 protein. The CYP2C19*3 allele exhibits a clinically-relevant SNP (c.636G>A) in exon 3 that results in a W212X coding change. This alteration in protein sequence abolishes the enzymatic activity of the cytochrome P450 2C19*3 protein.", + "output": "CYP2C19, c.636G>A (CYP2C19 gene)" + }, + { + "input": "Definition: something described as less than 8 mmHg of elevated intraocular pressure (EIOP); no visual field deficit", + "output": "Grade 1 Glaucoma, CTCAE (Glaucoma, CTCAE)" + }, + { + "input": "Definition: Uricosuric Agents described as a benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.", + "output": "PROBENECID (Sulfonamides)" + }, + { + "input": "Definition: NOTCH1 gene described as human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes neurogenic locus notch homolog protein 1 protein, plays a role in developmental processes by controlling cell fate decisions.", + "output": "AOS5 (NOTCH1 gene)" + }, + { + "input": "Definition: something described as a fusion gene that results from a chromosomal translocation t(5;14)(q33;q32) which fuses the 5' part of the TRIP11 gene with the 3' part of the PDGFRB gene. This gene fusion is associated with chronic myelomonocytic leukemia.", + "output": "TRIP11-PDGFRB Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: GAIA Postnatally Diagnosed Congenital Microcephaly Level of Diagnostic Certainty described as level 2a Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks gestational age (GA), with GA assessed by either a certain last menstrual period (LMP) date with confirmatory 1st trimester (less than 14 weeks) or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, one of the following requirements is met: a) the measurement is taken within the first 24 hours after birth or at the end of the pregnancy taking into consideration the molding of the head; OR b) the measurement is taken greater than 36 hours and up to 6 weeks after birth or the end of the pregnancy with no apparent post-natal insult resulting in microcephaly.", + "output": "Level 2a Postnatally Diagnosed Congenital Microcephaly (Intellectual Product)" + }, + { + "input": "Definition: Biologically Active Substance described as selenoprotein F (162 aa, ~18 kDa) is encoded by the human SELENOF gene. This protein binds selenium and may play a role in protein folding.", + "output": "SEP15 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Receptor described as transmembrane sensor receptor proteins that are central components of the chemotactic systems of a number of motile bacterial species which include ESCHERICHIA COLI and SALMONELLA TYPHIMURIUM. Methyl-accepting chemotaxis proteins derive their name from a sensory adaptation process which involves methylation at several glutamyl residues in their cytoplasmic domain. Methyl-accepting chemotaxis proteins trigger chemotactic responses across spatial chemical gradients, causing organisms to move either toward favorable stimuli or away from toxic ones.", + "output": "Proteins, Methyl-Accepting Chemotaxis (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as control tag for genetic material (DNA, RNA, etc.) derived from human sources; does not replace indexing HUMAN TISSUE; for a human cell line for which there is not a more specific term, index human genetic material tag and CELL LINE; always index at the T level.", + "output": "human genetic material tag (Homo sapiens)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.", + "output": "negative regulation of cell wall cellulose biosynthesis (negative regulation of cellulose biosynthetic process)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of cellotriose metabolic process.", + "output": "positive regulation of cellotriose metabolism (positive regulation of carbohydrate metabolic process)" + }, + { + "input": "Definition: something described as a type of surgery in which instruments are inserted into part of the brain by going through the nose and the sphenoid bone (a butterfly-shaped bone at the base of the skull). Transsphenoidal surgery is used to remove tumors of the pituitary gland.", + "output": "transsphenoidal surgery (Head and Neck Surgery)" + }, + { + "input": "Definition: Finding described as a turning outward of the lip or lips, that is, eversion of the lips.", + "output": "Everted lips (Finding)" + }, + { + "input": "Definition: Medical Device described as artificial substitute, constructed of either synthetic or biological material, which is used for the repair of injured or diseased ears, including ear ossicles.", + "output": "ear/hearing prosthesis (Prosthesis)" + }, + { + "input": "Definition: VFQ25-Interviewer Administered Format Questionnaire Question described as national Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Interviewer-Administered Format - General Vision: How would you rate your eyesight now (with glasses or contact lens on, if you wear them), on a scale of from 0 to 10, where zero means the worst possible eyesight, as bad or worse than being blind, and 10 means the best possible eyesight?", + "output": "VFQ1A02 (Intellectual Product)" + }, + { + "input": "Definition: Expression Negative described as an indication that PAX5 expression has not been detected in a sample.", + "output": "Paired Box Protein Pax-5 Negative (Expression Negative)" + }, + { + "input": "Definition: Molecular Function described as catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced.", + "output": "glycerol dehydrogenase activity, NAD or NADP as acceptor (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent operative intervention indicated", + "output": "Grade 4 Obstruction Gastric, CTCAE (Finding)" + }, + { + "input": "Definition: Abnormal cardiac ventricle morphology described as rare congenital heart malformation with a single ventricle (HEART VENTRICLES) instead of the usual two.", + "output": "ventricle; common (Heart)" + }, + { + "input": "Definition: something described as cabinets designed to store, display, and provide ready access to small equipment, instruments, and materials used in medical treatment and other medical procedures. This furniture typically consists of stand-alone multiple-drawer, -shelf, or -shelf/drawer cabinets with a working surface (e.g., the top of the cabinet) appropriate for use while performing medical treatment. The cabinets usually have hinged or sliding (either glass or solid) doors; some cabinets also include built-in grounded outlets, security locks, and/or small wheels for easy movement. Treatment cabinets are used for general treatments in emergency situations or in the field. Some are specially designed to perform particular procedures such as anesthesia, dentistry, ophthalmology, and otorhinolaryngolog..", + "output": "Cabinets, Treatment (Cabinet)" + }, + { + "input": "Definition: something described as functions of the range and ease of movement of more than one joint.", + "output": "Mobility of several joints (Organism Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O.", + "output": "selenite reductase activity (oxidoreductase activity, acting on NAD(P)H)" + }, + { + "input": "Definition: Medical Device described as water purification systems designed for filtration, carbon adsorption, and removal of charged particles (i.e., deionization) from the water. These systems typically consist of several containers intended to perform some or all of the following sequence of operations; (1) filtering to eliminate large particulates; (2) addition of a softener to eliminate calcium and magnesium; (3) elimination of low-molecular weight organic materials using a carbon bed; (4) deionization using both cationic and anionic resins. Filtering/deionization water purification systems when used alone do not eliminate or kill microorganisms; they are intended to provide soft \"treated\" water (i.e., a low content of metals such as calcium and magnesium) for use in healthcare facilities in areas such as clinical laboratories, pharmacies, and/or for clinical procedures (e.g., hemodialysis); the systems are also used in healthcare facilities and at home for purposes different from medical use.", + "output": "Water Purification Systems, Filtering/Deionization (Medical Device)" + }, + { + "input": "Definition: Other cerebral degeneration described as a disabling degenerative disease of the nervous system occurring in middle-aged or older persons and characterized by dementia and failure of memory for recent events, followed by total incapacitation and death. Types of the Alzheimer syndrome are differentiated by the age of onset and genetic characteristics. The early onset form (the mean age of the onset of symptoms between the ages of 40 and 60 years) and the late onset form (the onset of symptoms after the age of 60 years). Three forms are identified: AD-1, AD-2, AD-3. Some of the clinical characteristics of the Alzheimer syndrome are similar to those of the Pick syndrome.", + "output": "Senile Dementia (Mental disorders)" + }, + { + "input": "Definition: Mollusca described as a class in the phylum MOLLUSCA comprised of mussels; clams; OYSTERS; COCKLES; and SCALLOPS. They are characterized by a bilaterally symmetrical hinged shell and a muscular foot used for burrowing and anchoring.", + "output": "bivalves (Eukaryote)" + }, + { + "input": "Definition: something described as a broadly expressed type D cyclin. Experiments using KNOCKOUT MICE suggest a role for cyclin D3 in LYMPHOCYTE development.", + "output": "Cyclin-D3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud.", + "output": "cell migration involved in prostatic bud elongation (Reproductive process)" + }, + { + "input": "Definition: SOWS Subjective Questionnaire Question described as subjective Opiate Withdrawal Scale - My muscles twitch.", + "output": "SOWS Subjective (Handelsman) - My Muscles Twitch (Intellectual Product)" + }, + { + "input": "Definition: Chromosome Aberrations described as aberrant chromosomes with no ends, i.e., circular.", + "output": "ring chromosomes (Chromosomes)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a preparation of allogeneic, 'off-the-shelf' (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a monoclonal antibody specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are deleted from the CAR T-cells. Upon administration, the allogeneic anti-BCMA CAR-transduced T-cells ALLO-715 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Deletion of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The donor-derived, gene-edited CAR T cells have reduced production times and have increased availability when compared to autologous CAR-T cells, which use the patient's own cells and are produced on an individual basis. In addition, if the ALLO-715 cells cause unacceptable side effects, the incorporated CD20-based off-switch permits selective depletion of the ALLO-715 cells when the anti-CD20 monoclonal antibody rituximab is administered.", + "output": "ALLO-715 (Chimeric Antigen Receptor T-cells)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Child Report (PedsQL Neuromuscular Module Version 3.0 Young Child Report) Think about how you have been doing for the last few weeks. Please listen carefully to each sentence and tell me how much of a problem this is for you: It is hard to use my hands.", + "output": "PQL07-Hard to Use Hands (PedsQL Neuromuscular Module Version 3.0 Young Child Report Questionnaire Question)" + }, + { + "input": "Definition: something described as phagocytosis Induction involves initiation of the process of endocytosis of particulate material by phagocytes, such as microorganisms or cellular fragments and debris, into membranous phagosomes that fuse with lysosmes and result in digestion of the ingested material; an important defense against infection.", + "output": "Phagocytosis Induction (Endocytosis)" + }, + { + "input": "Definition: something described as an orally available botanically-based agent with potential antineoplastic activity. Upon oral administration, the components in BEL-X-HG may exert cytotoxic effects against cancer cells.", + "output": "Botanical Agent BEL X HG (Antineoplastic Plant Product)" + }, + { + "input": "Definition: something described as oximeters designed for determination of only a small number of critical parameters (e.g., oxygen saturation, total hemoglobin) at the point of Care. These oximeters use smaller whole-blood samples and are simpler to operate than laboratory oximeters, while producing fast and reasonably accurate results. Point-of-care oximeters are used in sites such as surgical suites, cardiac catheterizations areas, critical care rooms, and the patient's bedside.", + "output": "Oximeters, In Vitro, Point-of-Care (Medical Device)" + }, + { + "input": "Definition: response to mineralocorticoid described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus.", + "output": "response to 11-deoxycorticosterone (response to ketone)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a glycoengineered, humanized IgG1 monoclonal antibody with potential antineoplastic activity. Obinutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C70741\" active clinical trials using this agent.", + "output": "chemotherapeutics obinutuzumab (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as glasgow Coma Scale-NINDS Version (GCS NINDS Version) GCS Confounder Type: alcohol or drugs of abuse.", + "output": "GCS NINDS Version - Confounder: Alcohol or Drug of Abuse (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as point-of-care whole blood analyzers designed to measure the concentration of glucose, cholesterol, and lipids usually in a capillary blood sample (e.g., from a fingerstick). These analyzers may use one or more technologies such as reflectance photometry (i.e., by measuring the amount of light that is reflected from reagent-impregnated test pads or reagent strips that have reacted with the blood sample) and/or electrochemical methods. Glucose/lipid profile analyzers are capable of determining the concentration of glucose, high-density lipoprotein (HDL) and total cholesterol, and triglycerides. Some other related values (e.g., low-density lipoprotein [LDL] cholesterol) may be obtained using the analyzer software. The results are shown in the analyzer display; some analyzers include a printer for immediate printing of the results. Point-of-care glucose and lipid profile analyzers are used at the bedside, in operating rooms, and emergency departments; some are also intended for home use by patients with diabetes and/or heart diseases.", + "output": "Analyzers, Point-of-Care, Whole Blood, Glucose/Lipid Profile (Medical Device)" + }, + { + "input": "Definition: something described as a unit of concentration equal to millimoles per liter, divided by milligrams per kilogram per day.", + "output": "umol/L/(ug/kg/d) (Quantitative Concept)" + }, + { + "input": "Definition: something described as one of twenty six regions, zones, and nuclei that constitute the motor lateral hypothalamus. It is located ventral to the fornix in the lateral hypothalamic area at the level of the intermediate hypothalamic region of the rat. It is composed of three parts: the anterior zone of the subfornical region, the posterior zone of the subfornical region and the premammillary zone of the subfornical region. Functionally it belongs to the subcortical motor system ( Swanson-2004 ).", + "output": "subfornical region (motor lateral hypothalamus)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport.", + "output": "down-regulation of maltopentaose transport (Cell Function)" + }, + { + "input": "Definition: Data Table described as a table of data specifically regarding minimal residual disease.", + "output": "Minimal Residual Disease Table (Intellectual Product)" + }, + { + "input": "Definition: something described as distal (long) arm of chromosome 9", + "output": "Chromosome 9 Long Arm (Arm of chromosome)" + }, + { + "input": "Definition: Mental Process described as ability to recognize various speech sounds including, syllables, rhymes, and phonemes.", + "output": "Phonological Awareness (Awareness)" + }, + { + "input": "Definition: GNAS Protein Variant described as a change in the amino acid residue at position 227 in the guanine nucleotide-binding protein G(s) subunit alpha isoforms short protein where glutamine has been replaced by glutamic acid.", + "output": "GNAS Q227E (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a subjective score of 1 on a shortness of breath scale that ranges from 0: No Shortness of Breath to 10: Worst Possible Shortness of Breath.", + "output": "Shortness of Breath Score 1 (Shortness of Breath Visual Analogue Scale)" + }, + { + "input": "Definition: Pharmacologic Substance described as a class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.", + "output": "Antihistamine, Second Generation (Histamine Antagonists)" + }, + { + "input": "Definition: something described as a magnesium test system is a device intended to measure magnesium levels in serum and plasma. Magnesium measurements are used in the diagnosis and treatment of hypomagnesemia (abnormally low plasma levels of magnesium) and hypermagnesemia (abnormally high plasma levels of magnesium).", + "output": "ATOMIC ABSORPTION, MAGNESIUM (Medical Device)" + }, + { + "input": "Definition: Developmental process described as the process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors.", + "output": "dedifferentiation (Developmental process)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.", + "output": "Prostate Cancer Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as this gene is involved in pre-initiation of DNA replication.", + "output": "DOUBLE PARKED, DROSOPHILA, HOMOLOG OF (Licensing Factor Gene)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as a childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.", + "output": "Behavioral Insomnia of Childhood (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Cell described as human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of healthy individuals and transduced with a retroviral vector encoding the human cytokine interferon beta (IFNb), with potential immunomodulating and antineoplastic activities. Upon administration of IFNb-secreting MSCs, the cells are attracted and specifically migrate to tumor sites and become part of the tumor microenvironment. Since the MSCs express IFNb, these cells selectively deliver high levels of IFNb to the tumor site. In turn, IFNb binds to IFN-specific cell surface receptors and modulates the transcription and translation of certain genes whose protein products are involved in tumor cell proliferation. This decreases tumor cell growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123724\" active clinical trials using this agent.", + "output": "MSC-IFN beta (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Immunologic Factor described as a proprietary DNA-based cancer vaccine that encodes a melanoma antigen tyrosinase-related protein 2 (TRP2) cytotoxic T-lymphocyte (CTL) epitope and a modified monoclonal antibody, a chimera of human IgG1/murine IgG2a with T cell mimotopes expressed within the complementarity-determining regions (CDR) of the antibodies, with potential immunostimulating and antineoplastic activities. Upon intramuscular injection and electroporation, melanoma TRP2 CTL epitope vaccine SCIB1 expresses the modified antibody. Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91380\" active clinical trials using this agent.", + "output": "Melanoma TRP2 CTL Epitope Vaccine SCIB1 (Immunologic Factor)" + }, + { + "input": "Definition: Antibiotic described as a second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active against many strains resistant to other cephalosporins, such as Enterobacter species and indole-positive Proteus species.", + "output": "Product containing cefamandole (Drug allergens)" + }, + { + "input": "Definition: Abnormal CSF protein level described as CSF total protein level is below the lower limit of normal.", + "output": "Cerebrospinal fluid protein decreased (Cerebrospinal fluid tests)" + }, + { + "input": "Definition: Menstrual cycle described as menstruation", + "output": "Menstruation (Organism Function)" + }, + { + "input": "Definition: Abnormal oral mucosa morphology described as recurrent disease of the oral mucosa of unknown etiology, characterized by small white ulcerative lesions lasting 7 to 14 days.", + "output": "aphthous ulcers (Mouth and Teeth)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transcriptional activation.", + "output": "early B-cell factor (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as cabinets designed to store, display, and provide ready access to dental instruments, devices, and materials (e.g., local anesthetics, cement) during dental treatments; they also have a working surface (e.g., the top of the cabinet) that may include a sink intended to facilitate the dental procedure. This furniture typically consists of a stand-alone, stainless steel multiple drawer, shelf, or shelf/drawer cabinet, they may have hinged or sliding (either glass or solid) doors. Dental cabinets may have attachments for handpieces, a high volume evacuator, and a saliva ejector; some also include built-in grounded outlets, security locks, and/or small wheels for easy movement. They are used in dental clinics and offices during the performance of dental procedures, including oral surgery.", + "output": "Dental cabinet (Cabinets, Treatment)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with interleukin-11.", + "output": "interleukin-11 binding (Molecular Function)" + }, + { + "input": "Definition: something described as the relative timing of the expected onset of the targeted injury, with respect to radiation exposure.", + "output": "Exp Onset of Rad/Nuc Targeted Injury (Temporal Concept)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 11q", + "output": "11q12.1 (Chromosome band)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.", + "output": "regulation of filamentous growth (Organism Function)" + }, + { + "input": "Definition: Other Anatomic Concept described as a vague term that usually refers to the phagocytic cells (macrophages) of the spleen.", + "output": "Splenocytes (Cell)" + }, + { + "input": "Definition: Cells described as cardinal cell part which is demarcated from other cell parts by one or more anatomical planes. Examples: apical part of cell, cilium, head of spermatozoon.", + "output": "Cell region (Cells)" + }, + { + "input": "Definition: something described as blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.", + "output": "Embolisms, Gas (Embolism)" + }, + { + "input": "Definition: Organic Chemical described as a cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions; tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61079\" active clinical trials using this agent.", + "output": "vitamin E paclitaxel emulsion (Organic Chemical)" + }, + { + "input": "Definition: something described as a question about an oncologist's primary goal for the patient's current cancer treatment.", + "output": "If you had to choose one, what would you say is your loved one's oncologist's primary goal of their current cancer treatment (Intellectual Product)" + }, + { + "input": "Definition: Males described as a male individual who has had his testicles removed.", + "output": "Neutered Male (Male reproductive finding)" + }, + { + "input": "Definition: something described as catalysis of the reaction: biotin amide + H2O = biotin + NH3.", + "output": "biotinidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a porin that acts in the assembly of fimbria together with fimbrial chaperone.", + "output": "fimbrial usher porin activity (Molecular Function)" + }, + { + "input": "Definition: something described as any structural anomaly of the lung.", + "output": "Abnormality of lung morphology (Abnormal respiratory system morphology)" + }, + { + "input": "Definition: Gingiva described as the space between a tooth and the surrounding gingival tissue and lined by the sulcular epithelium.", + "output": "gingival crevice (Gingival part)" + }, + { + "input": "Definition: Bony skeleton subdivision described as the portion of the skull that forms the floor on which the brain lies; the internal surface of the cranial base has three large depressions that lie on different levels known as the anterior, middle, and posterior cranial fossae.", + "output": "of skull base (Bony skeleton subdivision)" + }, + { + "input": "Definition: Homeopathic remedies letter Z described as any elsewhere undefined homeopathic remedy letter Z, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "undef.homeo rmds ltr Z narr (Pharmacologic Substance)" + }, + { + "input": "Definition: Chromosome 11 Physical Location described as physical location of HTR3_Gene", + "output": "11: 113351120-113366245 (Chromosome 11 Physical Location)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - Retropulsion pull test.", + "output": "UHDRS 1999 Version - Retropulsion Pull Test (Intellectual Product)" + }, + { + "input": "Definition: Indicator described as an indication as to whether lymphovascular invasion by tumor cells has occurred.", + "output": "LVINVIND (Indicator)" + }, + { + "input": "Definition: pentosyltransferase described as pentosyltransferases that catalyze the reaction between a pyrimidine nucleoside and orthophosphate to form a free pyrimidine and ribose-5-phosphate.", + "output": "Phosphorylases, Pyrimidine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Facial Pain described as painful sensation in the face.", + "output": "Pain of face (Facial Pain)" + }, + { + "input": "Definition: Organ or Tissue Function described as any biological process involved in the maintenance of an internal steady state of creatinine.", + "output": "creatinine homeostasis (chemical homeostasis)" + }, + { + "input": "Definition: Finding described as moderate symptoms; medical intervention indicated", + "output": "Grade 2 Hyperparathyroidism, CTCAE (Finding)" + }, + { + "input": "Definition: something described as a species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotlie, non-spore forming, indole positive, produces major amounts of propionic acid, liquefies gelatin, hydrolyzes starch, but not esculin, and does not reduce nitrate. P. catoniae has been isolated from the gingiva of healthy individuals as well as from those with gingivitis or periodontal disease.", + "output": "Porphyromonas catoniae (Porphyromonas)" + }, + { + "input": "Definition: ANTI-INFECTIVE AGENTS FOR BACTERIA, VIRUSES AND FUNGI described as a type of antibiotic used to treat infection.", + "output": "Sulfonilamide (Medicinal product categorized by disposition)" + }, + { + "input": "Definition: something described as the 1.0 version of the CDISC Breast Cancer therapeutic area user guide.", + "output": "CDISC Breast Cancer Therapeutic Area User Guide Version 1.0 (CDISC Therapeutic Area User Guide Name and Version)" + }, + { + "input": "Definition: something described as mental retardation with characteristic facies (telecanthus, epicanthus, broad and flat nose, large inverted W-shaped mouth, and malformed ears) and limb abnormalities (camptodactyly, clinodactyly, interdigital webbing, and joint laxity).", + "output": "cerebrofacio-articular syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines described as catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium.", + "output": "8-oxoguanine deaminase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)" + }, + { + "input": "Definition: something described as a topical local anesthetic preparation that is composed of a mixture of lidocaine and prilocaine. It is used to provide anesthesia during minor surgery and for the treatment of PREMATURE EJACULATION.", + "output": "Lidocaine, Prilocaine Drug Combination (Local Anesthetics)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source.", + "output": "acetoin metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.", + "output": "up regulation of transforming growth factor-beta1 production (Organism Function)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) With regard to your physical health, during the past week how much of the time have you: felt full of pep and vitality?", + "output": "QLES1-Felt Full of Pep and Vitality (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the use of compression garments to prevent the development of peripheral neuropathy.", + "output": "Compression Therapy for Neuropathy Prevention (Compression procedure)" + }, + { + "input": "Definition: Professional or Occupational Group described as multidisciplinary team most frequently consisting of INTENSIVE CARE UNIT trained personnel who are available 24 hours per day, 7 days per week for evaluation of patients who develop signs or symptoms of severe CLINICAL DETERIORATION.", + "output": "Team, Rapid Response (Patient Care Team)" + }, + { + "input": "Definition: Pharmacologic Substance described as a quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS)related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61827\" active clinical trials using this agent.", + "output": "Product containing mefloquine (Antimalarials)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of Streptococcus pneumoniae serotype 11A IgG antibody present in a sample.", + "output": "Streptococcus pneumoniae Serotype 11A IgG Antibody (Streptococcus pneumoniae IgG Antibody Measurement)" + }, + { + "input": "Definition: Adenocarcinoma with metaplasia described as a malignant neoplasm arising from glandular cells that includes focal or extensive areas of squamous metaplasia.", + "output": "Adenocarcinoma with squamous metaplasia (Primary malignant adenomatous neoplasm)" + }, + { + "input": "Definition: something described as any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.", + "output": "epidermal cell division (Cell division)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual feels or felt that people act as if they think the individual is not smart.", + "output": "People act as if they think you are not smart (Intellectual Product)" + }, + { + "input": "Definition: something described as patient Health Questionnaire Screener Version (PHQ Screener Version) Over the last 4 weeks, how often have you been bothered by feeling restless so that it is hard to sit still?", + "output": "PHQ03-Feeling Restless (PHQ Screener Version Questionnaire Question)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of DNA helicases that participate in DNA REPLICATION. They assemble into hexameric rings with a central channel and unwind DNA processively in the 5' to 3' direction. DnaB helicases are considered the primary replicative helicases for most prokaryotic organisms.", + "output": "Helicase, DnaB (Enzyme)" + }, + { + "input": "Definition: something described as potassium voltage-gated channel subfamily KQT member 1 (676 aa, ~75 kDa) is encoded by the human KCNQ1 gene. This protein is involved in cardiac repolarization through modulation of potassium ion transport.", + "output": "Potassium Voltage-Gated Channel Subfamily KQT Member 1 (Ion Channel Protein)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had depression.", + "output": "Has Depression (Findings-Based Question)" + }, + { + "input": "Definition: codeine described as narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.", + "output": "Hydrocodone (Opiates)" + }, + { + "input": "Definition: something described as slippage of the FEMUR off the TIBIA.", + "output": "Dislocation of knee, NOS (Knee joint finding)" + }, + { + "input": "Definition: Disease or Syndrome described as a stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus.", + "output": "Nuclear Cataract Grade 1 (Nuclear non-senile cataract)" + }, + { + "input": "Definition: Degenerative disorder of muscle described as a weakening, shrinking, and loss of muscle caused by disease or lack of use. Muscle wasting decreases strength and the ability to move.", + "output": "Muscle atrophy, NOS (Lesion of skeletal muscle structure)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the spectrin beta, non-erythrocytic 2 (SPTBN2) gene, located at chromosome 11q13.2, which encodes the protein spectrin beta chain, non-erythrocytic 2. Genetic variants at this locus have been associated with spinocerebellar ataxia.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SPTBN2 (Medical Device)" + }, + { + "input": "Definition: something described as interactions between members of a community and representatives of the hospitals within that community.", + "output": "hospital community relations (Health Care Activity)" + }, + { + "input": "Definition: Parietal serous membrane described as the outermost of the two pleural membranes. It consists of a thin basal layer of fibrous tissue upon which sits a continuous layer of mesothelial cells. The cells function to secrete the lubricant lining the pleural cavity.", + "output": "Parietal Pleura (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Adenofibroma described as a benign or borderline adenofibroma characterized by the presence of serous secretory cells and minute cystic spaces filled with watery fluid. A representative example is the ovarian serous adenofibroma.", + "output": "Serous adenofibroma (Neoplastic Process)" + }, + { + "input": "Definition: Enzyme described as m-phase inducer phosphatase 2 (580 aa, ~65 kDa) is encoded by the human CDC25B gene. This protein plays a role in progression through the mitotic cell cycle.", + "output": "CDC25Hu2 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Geographic Area described as a state in south western Mexico bordering on the Pacific Ocean. Its capital is Colima.", + "output": "Colima (Mexican State)" + }, + { + "input": "Definition: PSA Level Finding described as a blood concentration of prostate specific antigen between 5 and 10 ng/mL.", + "output": "Five to Ten (Laboratory or Test Result)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a self-report screening test for depression and depressive disorder measuring symptoms defined by the American Psychiatric Association Diagnostic and Statistical Manual (DSM-V) for a major depressive episode.", + "output": "Center for Epidemiologic Studies Depression Scale-Revised (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.", + "output": "downregulation of glial cell differentiation (Cell Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as the hydrochloride salt form of boxidine, an agent that inhibits the transformation of 7-dehydrocholesterol to cholesterol and also inhibits sterol absorption.", + "output": "boxidine hydrochloride (Organic Chemical)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as thin, highly vascular membrane covering most of the posterior of the eye between the retina and sclera.", + "output": "choroid uvea (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as works consisting of lists of the events, pieces, performers, speakers, etc., of an entertainment, ceremony, or the like.", + "output": "Program (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human GRIN2B wild-type allele is located in the vicinity of 12p12 and is approximately 419 kb in length. This allele, which encodes glutamate receptor ionotropic, NMDA 2B protein, is involved in both glutamate binding and calcium transport. Mutation of the gene and chromosomal translocations involving the gene, t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1), are associated with mental retardation.", + "output": "NMDAR2B (Gene or Genome)" + }, + { + "input": "Definition: Transport Containers, Mechanical Protection described as containers designed to provide appropriate mechanical protection during transportation of clinical specimens (i.e., samples) using mail services or other transportation means. These containers may consist of one of a variety of devices (boxes, tubes, envelopes) made of different shapes, materials, and sizes and/or having other special characteristics (e.g., cushions, pockets) appropriate to provide protection for fragile items such collection/transportation vials, bottles, or tubes containing clinical samples (e.g., urine, feces) sent to the clinical laboratory.", + "output": "Specimen Mechanical Protection Transport Container (Transport Containers, Mechanical Protection)" + }, + { + "input": "Definition: something described as a CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.", + "output": "Inducible NOS Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the cyclin dependent kinase like 5 (CDKL5) gene, located at chromosome Xp22, which encodes the protein cyclin-dependent kinase-like 5. Genetic variants at this locus have been associated with early infantile epileptic encephalopathy 2 and Angelman syndrome.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CDKL5 (Medical Device)" + }, + { + "input": "Definition: Congenital Disorders described as a rare inborn error of metabolism characterized by persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine which manifests with encephalopathy, severe global developmental delay, mild to severe liver dysfunction, hypotonia and facial dysmorphism (most significant is frontal bossing, macrocephaly, hypertelorism and depressed nasal bridge). Epileptic seizures, hypoglycemia and/or cardiac defects (pulmonary stenosis, atrial and/or ventricular septal defect, coarctation of the aorta) may be associated. Clinical picture may range from neurological symptoms only to multi-organ involvement. There is evidence the disease is caused by homozygous mutation in the ADK gene on chromosome 10q22.", + "output": "hypermethioninemia encephalopathy due to deficiency of adenosine kinase (Congenital Disorders)" + }, + { + "input": "Definition: Vulvar Neoplasms described as a benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vulva. Representative examples include vestibular papilloma, intraepithelial neoplasia, and squamous cell carcinoma.", + "output": "Vulvar Squamous Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Peritoneal Dialysis described as peritoneal catheters designed to infuse a solution (dialysate) into the peritoneal cavity that allows metabolic wastes and water to diffuse from the blood using the peritoneum as the dialyzing membrane. Most of these catheters are made of silicone and are provided with Dacron cuffs that promote tissue growth inside to seal the catheter, preventing pericatheter fluid leaks and bacterial penetration. Most of these catheters are percutaneously inserted for both permanent use or acute conditions, but some permanent catheters require surgical implantation, and other semirigid catheters may be used only for one-session dialysis. Peritoneal dialysis catheters are used in manual (continuous ambulatory peritoneal dialysis) and automated (continuous cyclic peritoneal dialysis) therapies. These catheters may also be used for intraperitoneal chemotherapy (e.g., pancreatic or colorectal cancer) and to eliminate fluid overload in congestive heart failure.", + "output": "catheter dialysis peritoneal (Peritoneal Dialysis)" + }, + { + "input": "Definition: something described as human RNF216 wild-type allele is located in the vicinity of 7p22.1 and is approximately 162 kb in length. This allele, which encodes E3 ubiquitin-protein ligase RNF216 protein, plays a role in both protein ubiquitination and catabolism. Mutation of the protein is associated with cerebellar ataxia and hypogonadotropic hypogonadism.", + "output": "CAHH (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as nuclear medicine tables that include an exerciser, usually an ergometer bicycle, and shoulder/chest harness and hand grips . Most tables allow adjustment of the patient's vertical position, permitting radionuclide imaging under stress in any position from upright to supine.", + "output": "Stress Tables, Nuclear Cardiology (Tables, Imaging, Nuclear Medicine)" + }, + { + "input": "Definition: something described as the measurement of a lesion or location in the 'X' (first or length) dimension. EXAMPLE(S): OTHER NAME(S): NOTE(S): This is the longest measurement or largest value if only one measurement is captured.", + "output": "Performed Lesion Description X Dimension (Quantitative Concept)" + }, + { + "input": "Definition: Amniotic Fluid described as a clinical finding in which there is the accumulation of excessive fluid in the interstitial spaces, and appears as swelling on visual inspection.", + "output": "SWELLING (General finding of observation of patient)" + }, + { + "input": "Definition: Finding described as eyelid carcinoma with a finding of carcinoma in situ.", + "output": "Eyelid Carcinoma pTis TNM Finding v8 (Eyelid Carcinoma Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Microcephaly described as disease with characteristics of intrauterine and postnatal growth retardation, microcephaly, facial dysmorphism, skeletal dysplasia, low-birth weight and brain anomalies. Although microcephalic osteodysplastic primordial dwarfism (MOPD) types 1 and 3 were originally described as two separate entities on the basis of radiological criteria (notably small differences in pelvic and long bone structure), later reports confirmed that the two forms represent different modes of expression of the same syndrome. Although the causative gene remains unknown, homozygosity mapping has allowed identification of a candidate gene region on chromosome 2q (2q14.2-q14.3). Histological studies suggest that MOPD types 1 and 3 result from a basic defect in cell proliferation and tissue differentiation. Transmitted as autosomal recessive trait.", + "output": "Primordial microcephalic dwarfism Crachami type (Hereditary Connective Tissue Disorder)" + }, + { + "input": "Definition: Conceptual Entity described as an indication as to whether the study involves an FDA-regulated drug.", + "output": "FDA-Regulated Drug Study Indicator (Conceptual Entity)" + }, + { + "input": "Definition: something described as lymph node(s) adjacent to the ileocecocolic junction.", + "output": "LYMPH NODE, ILEOCECOCOLIC (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Biologically Active Substance described as a metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).", + "output": "Hexanedioic acid, 2-amino- (CARBOXYLIC ACIDS AND SALTS)" + }, + { + "input": "Definition: Dislocation of joint of upper limb described as displacement of the HUMERUS from the SCAPULA.", + "output": "Dislocation of shoulder region (Limb structure)" + }, + { + "input": "Definition: something described as occasional/minimal production of sputum with cough", + "output": "Grade 1 Productive cough (Productive Cough, CTCAE)" + }, + { + "input": "Definition: something described as an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.", + "output": "RICOLINOSTAT (Pharmacologic Substance)" + }, + { + "input": "Definition: Virus described as a group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).", + "output": "msv (Gammaretrovirus)" + }, + { + "input": "Definition: Site specific injuries NEC described as a method of euthanasia whereby a subject's head is removed from the body.", + "output": "DECAPITATION (Wounds, Penetrating)" + }, + { + "input": "Definition: FACT-L Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Lung Version 4 - Emotional Well-Being: I am losing hope in the fight against my illness.", + "output": "FAC016-Losing Hope Against Illness (Intellectual Product)" + }, + { + "input": "Definition: Plant described as all of the component parts of a plant, whether above or below the roots.", + "output": "Planta (Plant Part)" + }, + { + "input": "Definition: something described as a chromosome band present on 10p", + "output": "10p12.1 (Cell Component)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in cell cycle arrest.", + "output": "NDN (Genes, cdc)" + }, + { + "input": "Definition: ECG Measurement described as an electrocardiographic measurement of the minimum number of ventricular depolarizations (QRS complexes) recorded during a specified, extended period of time, and usually expressed in beats per minute.", + "output": "EGVRMIN (ECG Measurement)" + }, + { + "input": "Definition: RPSA gene described as human RPSA wild-type allele is located in the vicinity of 3p22.2 and is approximately 6 kb in length. This allele, which encodes 40S ribosomal protein SA, plays a role in a variety of biological processes that are mediated by interactions with cell surface receptors.", + "output": "Laminin Receptor-1, 40S Ribosomal Protein SA Gene (RPSA gene)" + }, + { + "input": "Definition: something described as prostate Cancer Specific Quality of Life Instrument - Enjoying time with friends and family.", + "output": "PROS0107 (Intellectual Product)" + }, + { + "input": "Definition: something described as specialized NEURONS that produce hormones, such as NEUROPEPTIDES or BIOGENIC AMINES. They generally are in the NERVOUS SYSTEM, such as HYPOTHALAMUS, but can be found in other organs or systems. These neurons contain dense neurosecretory granules and PROPROTEIN CONVERTASES allowing the rapidly release of NEUROHORMONES into the blood circulation upon stimulation.", + "output": "Neuroendocrine Cells (Endocrine Cells)" + }, + { + "input": "Definition: something described as breast adenosis characterized by the presence of ducts with distended lumen and columnar cell metaplasia.", + "output": "Breast Blunt Duct Adenosis (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a species of aerobic or facultatively anaerobic, Gram-positive, coryneform, pleomorphic bacilli assigned to the phylum Actinobacteria. This species is nonmotile, non-spore forming, catalase and urease positive, oxidase and pyrazinamidase negative, non-lipophilic, reduces nitrate, and does not hydrolyze gelatin. C. pseudotuberculosis is known to cause caseous lymphadenitis in animals and can be pathogenic in humans.", + "output": "Mycobacterium tuberculosis-ovis (Corynebacterium)" + }, + { + "input": "Definition: something described as a measurement of the soluble vascular endothelial growth factor receptor 1 in a biological specimen.", + "output": "sVEGFR1 Measurement (Vascular Endothelial Growth Factor Receptor Measurement)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as e3 ubiquitin-protein ligase HERC2 (4834 aa, ~527 kDa) is encoded by the human HERC2 gene. This protein is involved in ubiquitin-dependent retention of DNA repair proteins.", + "output": "E3 Ubiquitin-Protein Ligase HERC2 (Enzyme)" + }, + { + "input": "Definition: Intellectual Product described as the Overactive Bladder Questionnaire Short Form - Accidental loss of small amounts of urine?", + "output": "OAB-q Short Form - Accidental Loss of Urine (OAB-q Short Form Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O.", + "output": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Surgical Clips described as surgical clips designed to hold small surgical instruments (e.g., needle holders, cannulae) during surgical procedures. These clips are typically small metal instruments with two blades crossed at the midportion, permitting manipulation in a cross-action, or joined at the midportion, resembling forceps or scissors. Instrument clips have blunt ends that do not perforate, tear, or damage instruments. Surgical instrument clips are designed for temporarily holding or attaching instruments during surgery; they may also be used in other medical procedures.", + "output": "Clips, Instrument (Surgical Instruments)" + }, + { + "input": "Definition: Virus described as a family of DNA viruses infecting plants and transmitted by APHIDS. Genera include NANOVIRUS and BABUVIRUS.", + "output": "Family Nanoviridae (Plant Viruses)" + }, + { + "input": "Definition: Bone structure of lower limb described as the bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the PATELLA; TIBIA; and FIBULA.", + "output": "of leg bones (Structure of appendicular skeleton)" + }, + { + "input": "Definition: something described as the process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure.", + "output": "petal structural organization (Biologic Function)" + }, + { + "input": "Definition: something described as a gastrointestinal bleeding adverse event in a newborn which results in death.", + "output": "Grade 5 Neonatal Gastrointestinal Bleeding, Adverse Event (Finding)" + }, + { + "input": "Definition: something described as this gene is involved in cell cycle regulation and DNA repair.", + "output": "Rad24 (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as tumor necrosis factor ligand superfamily member 14 (240 aa, ~26 kDa) is encoded by the human TNFSF14 gene. This protein is involved in the regulation of both T-cell proliferation and apoptosis.", + "output": "Tumor Necrosis Factor Superfamily Member 14 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as a structural anomaly of the mucous lining of the large intestine. []", + "output": "Abnormal large intestinal mucosa morphology (Anatomical Abnormality)" + }, + { + "input": "Definition: Intellectual Product described as mini-Mental State Examination 2 Standard Version (MMSE-2 Standard Version) Where are we now? What is the state (or province)?", + "output": "MMSE-2 Standard Version - What Is the State (Intellectual Product)" + }, + { + "input": "Definition: something described as a thin tube within the liver that collect bile secreted by hepatocytes. Many canaliculi come together to form bile ductules that ultimately form the common hepatic duct.", + "output": "Canaliculi, Bile (Liver)" + }, + { + "input": "Definition: Refractory Chronic Leukemia described as hairy cell leukemia that is resistant to treatment. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8030\" active clinical trials using this agent.", + "output": "hairy cell leukemia, recurrent (Neoplastic Process)" + }, + { + "input": "Definition: Infections NEC described as a rare acute life-threatening systemic bacterial noncontagious illness caused by any of several related staphylococcal exotoxins. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.", + "output": "Gramme-positive septic shock (Drug-related disorder)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying a classification of protocol deviation. EXAMPLE(S): major, minor", + "output": "PerformedProtocolDeviation.categoryCode (Intellectual Product)" + }, + { + "input": "Definition: something described as a bundle of fibers that arise at all spinal levels, cross the midline, ascend contralaterally in the anterior white column of the spinal cord and terminate in the dorsal accessory nucleus of the inferior olive and the medial accessory nucleus of the inferior olive in the medulla ( Oscarsson-1977; Carpenter-1983 ). It consists of the anterior spino-olivary tract of the spinal cord and the anterior spino-olivary tract of the medulla.", + "output": "anterior spino-olivary tract (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Nose described as the mucosal membranes that line the nasal cavity.", + "output": "Olfactory Membrane (Nose)" + }, + { + "input": "Definition: something described as the directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid.", + "output": "fatty acyl transport (Biological Transport)" + }, + { + "input": "Definition: Intellectual Product described as suicidal Ideation Questionnaire-JR - I thought about death.", + "output": "SIQ02-I Thought About Death (SIQ-JR Questionnaire Question)" + }, + { + "input": "Definition: Physical State described as a suspension of liquid within another liquid or a dispersion consisting of two or more liquid phases.", + "output": "Emulsions (Physical State)" + }, + { + "input": "Definition: something described as n-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.", + "output": "Pepstatins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as ubiquitin-conjugating enzyme E2 A (152 aa, ~17 kDa) is encoded by the human UBE2A gene. This protein is involved in the monoubiquitination of histone H2B.", + "output": "EC 6.3.2.19 (Ubiquitin-Conjugating Enzymes)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.", + "output": "prosthetic group binding (cofactor binding)" + }, + { + "input": "Definition: regulation of sodium-dependent phosphate transport described as any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport.", + "output": "positive regulation of sodium-dependent phosphate transport (regulation of sodium-dependent phosphate transport)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in brain development.", + "output": "Forkhead Box P2 Gene (Transcription factor genes)" + }, + { + "input": "Definition: Ophthalmological equipment described as a tonometer sterilizer is an AC-powered device intended to heat sterilize a tonometer (a device used to measure intraocular pressure).", + "output": "STERILIZER, TONOMETER (Ophthalmological equipment)" + }, + { + "input": "Definition: Finding described as life-threatening consequences (e.g. malignant hypertension: shock, cardiac failure or neonatal encephalopathy). Note: For percentile values: e.g. Dionne et al. Ped Nephrol 2012.", + "output": "Grade 4 Neonatal Hypertension, AE (Finding)" + }, + { + "input": "Definition: Finding described as the space that occupies the distance between the shortest free edge of the fetal membranes and the disc edge.", + "output": "Site of Fetal Membrane Rupture (Placental finding)" + }, + { + "input": "Definition: Enzymes described as an enzyme that catalyzes the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD. EC 5.5.1.4.", + "output": "Myo-Inositol-1-Phosphate Synthase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: negative regulation of metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone.", + "output": "down-regulation of hormone metabolic process (Molecular Function)" + }, + { + "input": "Definition: Aneurysm, Dissecting described as acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery.", + "output": "Dissection of coronary artery (Vascular)" + }, + { + "input": "Definition: Body Location or Region described as organ surface layert which constitutes the outermost layer of an organ.", + "output": "External surface layer of organ (Surface of organ)" + }, + { + "input": "Definition: Nail Changes, CTCAE 5.0 described as present", + "output": "Grade 1 Nail changes (Finding)" + }, + { + "input": "Definition: Acquired Abnormality described as an abnormal communication between the ureter and another organ or anatomic site.", + "output": "fistula; ureter (Acquired Abnormality)" + }, + { + "input": "Definition: Cell Function described as any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "output": "negative regulation of mesenchymal cell proliferation (Cell Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as assisting a patient in taking a partial bath to promote personal hygiene and/or comfort while remaining consistent with his or her religious beliefs. Service is billed in 15-minute increments.", + "output": "sprtlnrse partial B.asistnce (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: G-Protein-Coupled Receptors described as neuropeptide Y receptor type 5 (445 aa, ~51 kDa) is encoded by the human NPY5R gene. This protein is involved in diverse physiological functions as a receptor for neuropeptide Y.", + "output": "Neuropeptide Y Receptor Type 5 (Receptor)" + }, + { + "input": "Definition: something described as a solution or suspension present in a small volume or mass, intended for administration to the rectum.", + "output": "Micro Enema (Biomedical or Dental Material)" + }, + { + "input": "Definition: Vulvar Seborrheic Keratosis described as seborrheic keratosis that arises from follicular structures in the vulva. It is characterized by the presence of prominent squamous eddies.", + "output": "Vulvar Inverted Follicular Keratosis (inverted follicular keratosis)" + }, + { + "input": "Definition: something described as a concentration unit measured as a number of microgram equivalents per gram of substance.", + "output": "ngEq/mg (Quantitative Concept)" + }, + { + "input": "Definition: Multimodal Imaging described as a dual-modality imaging technique that merges data from single-photon emission computed tomography (SPECT) and computed tomography (CT) to provide structural and functional information.", + "output": "SPECT CT Scan (Tomography, Emission-Computed, Single-Photon)" + }, + { + "input": "Definition: regulation of vascular endothelial cell proliferation described as any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.", + "output": "down-regulation of vascular endothelial cell proliferation (negative regulation of endothelial cell proliferation)" + }, + { + "input": "Definition: something described as changes that occur to liberate the enzymes of the ACROSOME of a sperm (SPERMATOZOA). Acrosome reaction allows the sperm to penetrate the ZONA PELLUCIDA and enter the OVUM during FERTILIZATION.", + "output": "acrosome reaction (Reproductive process)" + }, + { + "input": "Definition: Operation on pleura described as aspiration of fluid or air from the THORACIC CAVITY. It is coupled sometimes with the administration of drugs into the PLEURAL CAVITY.", + "output": "pleurocentesis (Procedure on pleura)" + }, + { + "input": "Definition: Pharmacologic Substance described as a nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.", + "output": "1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride (Ganglionic Blockers)" + }, + { + "input": "Definition: N-succinyltransferase activity described as catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.", + "output": "delta-aminolevulinic synthetase activity (N-succinyltransferase activity)" + }, + { + "input": "Definition: Glomerulonephritis described as inflammation of the glomeruli, in which all glomeruli are affected, resulting in renal failure.", + "output": "Diffuse Glomerulonephritis (Disease or Syndrome)" + }, + { + "input": "Definition: Protection Garments, Environmental described as protection garment designed for personal protection of rescuers in contaminated areas. These garments typically include a body coverall made of a vapor permeable plastic laminate (e.g., polypropylene) that can repel drips, spills, and splashes; safety eyeglasses or a hood to cover the face and/or head; special gloves; and boots. Contamination emergency protection garments are used for temporary (typically some hours or a few days), limited protection in areas with low or medium contamination with chemical, biological, or radioactive particles; most of these garments are disposable. They do not offer protection from radiation.", + "output": "Protection Garments, Environmental, Contaminated Area Rescuer (Medical Device)" + }, + { + "input": "Definition: Thalamic structure described as a set of substructures of the thalamus grouped on the basis of connectivity and function in the functional CNS model ( Swanson-2004 ). It includes the anterior nuclear group, the intralaminar nuclear group and parts of the midline nuclear group, medial dorsal nucleus, lateral nuclear group, and posterior nuclear complex ( see Models Where It Appears below ).", + "output": "thalamus, polymodal association cortex related (Thalamic structure)" + }, + { + "input": "Definition: Epithelium described as the outermost layer of the renal capsule, which is composed of a single layer of simple squamous epithelium.", + "output": "Parietal layer of Bowman's capsule (Epithelium)" + }, + { + "input": "Definition: MUSCLE SOFT, TISSUE described as the muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.", + "output": "muscle; hypertrophy (Muscle related signs and symptoms NEC)" + }, + { + "input": "Definition: biochemical test described as a measurement of the homocitrulline in a biological specimen.", + "output": "Homocitrulline Measurement (biochemical test)" + }, + { + "input": "Definition: General Body States, Conditions and Activities described as the SMOKING of CIGARS.", + "output": "Cigar smoker (Tobacco smoking behavior)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any regimen that can be used for the treatment of small cell lung carcinoma.", + "output": "Regimen Used to Treat Small Cell Lung Carcinoma (Chemo/immuno/hormone Therapy Regimen)" + }, + { + "input": "Definition: United States National Institutes of Health described as component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.", + "output": "National Cancer Institute (Health Care Related Organization)" + }, + { + "input": "Definition: something described as a leucine aminopeptidase test system is a device intended to measure the activity of the enzyme leucine amino-peptidase in serum, plasma, and urine. Leucine aminopeptidase measurements are used in the diagnosis and treatment of liver diseases such as viral hepatitis and obstructive jaundice.", + "output": "L-LEUCINE-4-NITROANILIDE (COLORIMETRIC), LEUCINE ARYLAMIDASE (Medical Device)" + }, + { + "input": "Definition: something described as low-density lipoprotein receptor-related protein 6 (1613 aa, ~180 kDa) is encoded by the human LRP6 gene. This protein plays a role in the modulation of cell communication.", + "output": "LRP-6 (Receptor)" + }, + { + "input": "Definition: Characteristic of psychosocial functioning described as use of relaxing, interesting, and enjoyable activities to promote well-being", + "output": "Leisure behavior (Characteristic of psychosocial functioning)" + }, + { + "input": "Definition: FACT-HEP Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Additional Concerns: I feel fatigued.", + "output": "FAC01537 (FACT-HEP Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as a small portion of the caudal pontine reticular nucleus defined by some authors on the basis of Nissl stain. It is located ventromedially adjacent to the nucleus raphe magnus ( Paxinos-2009, Hof-2000 ).", + "output": "pontine reticular nucleus, ventral part (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: NCI CTEP SDC Lung, Mediastinal and Pleural Neoplasm Category Terminology described as lung, Mediastinal and Pleural Neoplasm, Miscellaneous is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology.", + "output": "Lung, Mediastinal and Pleural Neoplasm, Miscellaneous (NCI CTEP SDC Lung, Mediastinal and Pleural Neoplasm Category Terminology)" + }, + { + "input": "Definition: reproductive hormone described as hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.", + "output": "gonadotropins (reproductive hormone)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP.", + "output": "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as instrument tables including an appropriate (e.g., metal, plastic) top surface usually supported by a movable swivel caster base. Most tables include shelves, drawers, and instrument trays. These tables are designed for the anesthetic's use during general anesthetist surgical procedures.", + "output": "Anesthesia Instrument Tables (Medical Device)" + }, + { + "input": "Definition: Finding described as lack of information on the prescribed diet/food intake", + "output": "Knowledge Deficit of Dietary Regimen (Nursing Assessment Entity)" + }, + { + "input": "Definition: Interstitial tissue described as renal tissue consisting of peritubular and periarterial spaces. The relative contribution of each of these two spaces to interstitial volume varies, but increases in size from the cortex to the papilla. In the cortex there is little interstitium because the peritubular capillaries occupy most of the space between the tubules. The cortical interstitial cells and outer medula consist mainly of fibroblastic cells and mononuclear cells. The inner medulla consists primarily of pericytes, lipid-laden cells and mononuclear cells arranged like rungs of a ladder.", + "output": "Structure of interstitial tissue of kidney (Connective tissue by site)" + }, + { + "input": "Definition: General adjectival modifier described as consisting of or involving two parts or components, often in pairs.", + "output": "Dual (General Qualifier)" + }, + { + "input": "Definition: Disorder of oral mucous membrane described as a primary or metastatic malignant neoplasm involving the buccal mucosa.", + "output": "Malignant Buccal Mucosa Tumor (Malignant tumor of soft tissue of head)" + }, + { + "input": "Definition: Testicular germ cell tumor mixed described as a malignant germ cell tumor arising from the testis. It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements. Patients may present with painless or painful testicular swelling.", + "output": "choriocarcinoma and seminoma, testicular (Choriocarcinoma combined with other germ cell elements)" + }, + { + "input": "Definition: BBPS - Boston bowel preparation scale described as portion of mucosa of the colon segment seen, but other areas of the colon segment not well seen due to staining, residual stool and/or opaque liquid.", + "output": "Boston Bowel Preparation Segment Score 1 (Finding)" + }, + { + "input": "Definition: negative regulation of inositol phosphate biosynthetic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.", + "output": "negative regulation of inositol trisphosphate synthesis (Organism Function)" + }, + { + "input": "Definition: Age Group described as an age group comprised of individuals between 12 and 18 months of age.", + "output": "toddlers (Age Group)" + }, + { + "input": "Definition: something described as a form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers.", + "output": "Cobblestone Dysplasias (Congenital Abnormality)" + }, + { + "input": "Definition: something described as human PDHX wild-type allele is located in the vicinity of 11p13 and is approximately 105 kb in length. This allele, which encodes pyruvate dehydrogenase protein X component, mitochondrial protein, is involved in the regulation of pyruvate dehydrogenase activity. Mutation of the gene is associated with lactic acidosis due to pyruvate dehydrogenase E3-binding protein deficiency.", + "output": "proX (PDHX gene)" + }, + { + "input": "Definition: Records described as a collection of original digital data, and certified copies of collections of original digital data.", + "output": "eSource Record (Intellectual Product)" + }, + { + "input": "Definition: Temperament and personality functions described as general mental functions of constitutional disposition of the individual to react in a particular way to situations, including the set of mental characteristics that makes the individual distinct from others.", + "output": "Temperament and personality functions (Global mental functions)" + }, + { + "input": "Definition: Medical Device described as electronic storage data recorders designed to measure and record the amount, type, and timing of sleep typically during overnight or in 24-hour periods. These recorders usually consist of a small portable unit worn on the belt and physical parameter (e.g., electrooculograph, electromyograph) sensor electrodes attached to the patient's body. Recorders can store information analogous to that obtained in polysomnography studies, but for a limited set of parameters. Sleep/awake electronic storage recorders are used for ambulatory and/or home assessment of sleep disorders, such as hypersomnia and somnambulism.", + "output": "Recorders, Physiologic, Sleep/Awake (Medical Device)" + }, + { + "input": "Definition: Temporal Concept described as the phase of a disease characterized by laboratory and clinical findings that indicate rapid progression.", + "output": "Accelerated Phase of Disease (Temporal Concept)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Neisseria elongata.", + "output": "Neisseria elongata (Bacterium)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult Parent Report - In the past one month, how much of a problem has this been for your child: It is hard for my child to explain his or her illness to other people.", + "output": "PQL02-Hard Explain Illness to People (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report Questionnaire Question)" + }, + { + "input": "Definition: something described as a volume unit equal to one picoliter used as a denominator to build a derived unit expressed as a ratio.", + "output": "Per Picoliter (Quantitative Concept)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose.", + "output": "dolichylphosphate-mannose phosphodiesterase activity (phosphoric diester hydrolase activity)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) In the past 4 weeks, did the subject watch television?", + "output": "ADCS-ADL - Watch Television (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: something described as the directed movement of a substance from one side of an epithelium to the other.", + "output": "transepithelial transport (Cell Function)" + }, + { + "input": "Definition: something described as a cluster of neuronal cell bodies and their dendrites located just ventral and lateral to the spinal cord that give rise to the sympathetic nervous system.", + "output": "Para-Spinal Ganglion (Sympathetic Ganglia)" + }, + { + "input": "Definition: Hemophilus described as a species of gram-negative, facultatively anaerobic coccobacillus-shaped bacteria that has been isolated from pneumonic lesions and blood. It produces pneumonia with accompanying fibrinous pleuritis in swine.", + "output": "Actinobacillus pleuropneumoniae (Shope 1964) Pohl et al. 1983 (Actinobacillus)" + }, + { + "input": "Definition: Finding described as symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated", + "output": "Grade 2 Bronchial Stricture, CTCAE (Finding)" + }, + { + "input": "Definition: something described as chemically-engineered oligonucleotides used to selectively inhibit expression of target genes through sequence-specific binding of corresponding microRNA (miRNA) sites.", + "output": "Anti-miRs (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Hallucinogens described as a physiologically inactive constituent of Cannabis sativa L.", + "output": "Cannabinolo (Hallucinogens)" + }, + { + "input": "Definition: something described as human CYP11A1 wild-type allele is located within 15q23-q24 and is approximately 30 kb in length. This allele, which encodes cytochrome P450 11A1, mitochondrial protein, is involved in steroid synthesis. Certain allelic variants of the CYP11A1 gene result in 17-alpha-hydroxylase/17,20-lyase deficiency. Defects in this gene cause congenital adrenal insufficiency and congenital lipoid adrenal hyperplasia.", + "output": "CYP11A1 wt Allele (CYP11A1 gene)" + }, + { + "input": "Definition: Thyroid Diseases described as abnormally elevated THYROXINE level in the BLOOD.", + "output": "Hyperthyroxinemias (Thyroid Diseases)" + }, + { + "input": "Definition: actin cytoskeleton organization described as covalent modification of an actin molecule.", + "output": "actin modification (cellular protein modification process)" + }, + { + "input": "Definition: Trophoblastic Neoplasms described as a malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).", + "output": "choriocarcinoma NOS (Trophoblastic Neoplasms)" + }, + { + "input": "Definition: Classification described as thyroid dysfunction can present as hypo- or hyperactive thyroidal function. Hypothyroidism is thyroid hormone deficiency. Primary hypothyroidism is due to thyroid disease; TSH is increased. Most common cause is autoimmune. Other common causes are post-therapeutic, occurring after radioactive iodine therapy, surgery, radiation, or lithium therapy. Secondary hypothyroidism occurs when hypothalamus produces insufficient TRH or pituitary produces insufficient TSH. Signs and symptoms of hypothyroidism include: cold intolerance, constipation, personality changes, dementia or frank psychosis, hoarse voice, facial puffiness, coarse hair and skin, fluid retention, decreased metabolism, paresthesias, decreased libido, menstrual irregularities, bradycardia, pericardial effusions. Hyperthyroidism is excessive production of iodinated thyroid hormones, T3 and T4. Graves' disease (toxic diffuse goiter) is most common cause and is characterized by hyperthyroidism, goiter, exophthalmos, pretibial myxedema. Inflammatory thyroid disease (thyroiditis) includes subacute granulomatous thyroiditis, Hashimoto's thyroiditis, and silent lymphocytic thyroiditis. Drug-induced hyperthyroidism can result from lithium or interferon-alpha. Signs and symptoms of hyperthyroidism include: hyperactivity, increased sweating, increased appetite, weight loss, insomnia, weakness, frequent bowel movements, hypomenorrhea, tremor; tachycardia, atrial fibrillation. Eye signs include stare and eyelid retraction. Infiltrative ophthalmopathy is specific to Graves' disease. Thyroid storm is life-threatening emergency; patients may present with fever, psychosis, coma, cardiovascular collapse.", + "output": "Hyperthyroidism (Classification)" + }, + { + "input": "Definition: Systematized Nomenclature of Dentistry described as an autosomal dominant condition caused by mutation(s) in the FBN1 gene, encoding fibrillin-1. This condition is characterized by tall stature, disproportionately long limbs, arachnodactyly, and hyperextensible joints; additional features may include scoliosis, kyphosis, pectus excavatum/carinatum, mitral valve prolapse, aortic dilatation, aortic dissection, and upward subluxation of one or both ocular lens.", + "output": "Marfan's disease (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Necrosis of anatomical site described as chemic necrosis of the testis usually caused by torsion of the spermatic cord, trauma, or severe epididymo-orchitis.", + "output": "infarctions testicular (Disorder of testis and epididymis)" + }, + { + "input": "Definition: Quantitative Concept described as unit of measure of potency of allergenic product expressed as a number of standardized biological units per one milliliter of formulation.", + "output": "SBE/mL (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's eyes have or had excessive tearing.", + "output": "Do your eyes have excessive tearing (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Ectodermal Dysplasia described as ectodermal dysplasia is a group of conditions in which there is abnormal development of the skin, hair, nails, teeth, or sweat glands.", + "output": "Congenital Ectodermal Defects (Dermatologic disorders)" + }, + { + "input": "Definition: something described as catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate.", + "output": "D-galactose-6-phosphate ketol-isomerase activity (Molecular Function)" + }, + { + "input": "Definition: something described as species of Staphylococcus that is a spherical, nonmotile, gram positive, chemoorganotrophic, facultative anaerobe; mainly found on the skin and mucous membrane of warm blooded animals, it can be primary pathogen or secondary invader.", + "output": "Micrococcus pyogenes var. albus (S [Preparations])" + }, + { + "input": "Definition: something described as emotional attachment to someone or something in the environment.", + "output": "Pyschological Bonding (Mental Process)" + }, + { + "input": "Definition: Retinal microvascular finding described as escape of blood from the vessels of the innermost of the three tunics of the eyeball or retina.", + "output": "Retinal hemorrhage (Disorders of choroid and retina)" + }, + { + "input": "Definition: something described as a type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin.", + "output": "DEAE-Cellulose Chromatography (Ion-Exchange Chromatography Procedure)" + }, + { + "input": "Definition: nonenzyme proteolytic agent described as cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.", + "output": "CYANOGEN BROMIDE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Line of Therapy described as treatment that is given when the first five treatments don't work, or stop working.", + "output": "Sixth line of therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Venoms described as solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.", + "output": "Snake Venoms (Venoms)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.", + "output": "CD 197 ANTIGENS (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Syndrome described as mental retardation with growth deficiency, craniofacial deformities, heart defects, and dry and brittle hair. This and X-linked mental retardation 1 are considered similar but separate entities.", + "output": "MENTAL RETARDATION, X-LINKED 55 (Mental Retardation)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as transcription factor GATA-4 (442 aa, ~45 kDa) is encoded by the human GATA4 gene. This protein is involved in the regulation of transcription during cardiovascular development.", + "output": "GATA Binding Factor 4 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: Nephrosis, congenital described as nephrotic syndrome presenting within the first three months of life, and which is associated with an infectious process.", + "output": "Congenital Nephrotic Syndrome - Infection Associated (Nephrosis, congenital)" + }, + { + "input": "Definition: Finding described as a disorder characterized by involvement of the optic nerve (second cranial nerve).", + "output": "Optic Nerve Disorder (Eye Disorders, CTCAE)" + }, + { + "input": "Definition: Normal Laboratory Test Result described as a laboratory test result indicating the absence of Fanconi anemia group D2 protein nuclear foci in cells.", + "output": "Fanconi Anemia Group D2 Nuclear Foci Absent (Normal Laboratory Test Result)" + }, + { + "input": "Definition: Cell Function described as the vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.", + "output": "synaptic transmission, glutamatergic (Cell Function)" + }, + { + "input": "Definition: Research Activity described as in cancer prevention, a clinical trial that studies whether taking certain medicines, vitamins, minerals, or food supplements can prevent cancer.", + "output": "Chemoprevention Study (Cancer Prevention Trial)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an antibody-drug conjugate (ADC) composed of the trastuzumab biobetter HM2 conjugated, in a site-specific manner, to monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of ALT-P7, the antibody moiety targets and binds to human epidermal growth factor receptor 2 (HER2) on tumor cells. Upon antibody/antigen binding and internalization, the MMAE moiety is released, binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. HER2 is a receptor tyrosine kinase (RTK) that is overexpressed by many cancer cell types.", + "output": "HM2/MMAE antibody-drug conjugate ALT-P7 (Immunoconjugates)" + }, + { + "input": "Definition: Finding described as decreased ROM requiring small bites, soft foods or purees", + "output": "Grade 2 Trismus, CTCAE (Finding)" + }, + { + "input": "Definition: Findings-Based Question described as a question about the intensity of an individual's average pain.", + "output": "Level of Average Pain (Intellectual Product)" + }, + { + "input": "Definition: Lipids measurement described as the determination of the amount of very low-density lipoprotein cholesterol present in a sample.", + "output": "very low density lipoprotein (VLDL) level test (Serum total cholesterol measurement)" + }, + { + "input": "Definition: Intellectual Product described as physiologic recording software designed for later processing of physiologic data obtained while recording. This software is intended to work only with one or a few models of physiologic recorders, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the analysis of measurements performed during physiologic parameter recording; it may also be used to transmit and/or receive patient information from and to hospital information systems. Physiologic recording software is mainly intended for use with recorders and recorded data processors; some recorders include the software needed for processing the information using a standard computer (e.g., a personal computer). Dedicated software for analysis of the recording of one or more physiologic parameter (e.g., blood pressure, temperature) is also available.", + "output": "Physiologic Recording Software (Computer software)" + }, + { + "input": "Definition: Intellectual Product described as a terminology subset of the CDISC SDTM Unit codelist created for CDASH Units for Planned Exposure codelist.", + "output": "EXPDOSEU (Intellectual Product)" + }, + { + "input": "Definition: Forkhead Transcription Factors described as a forkhead box transcription factor that is expressed primarily in adult organs which contain proliferating cells such as the thymus, testis, ovary, and small intestine. It controls the expression of CELL CYCLE genes essential for DNA REPLICATION and MITOSIS, and also functions in DNA REPAIR.", + "output": "FOXM1 Protein (Forkhead Transcription Factors)" + }, + { + "input": "Definition: Organic Chemical described as an immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26660\" active clinical trials using this agent.", + "output": "MLN2704 (Pharmacologic Substance)" + }, + { + "input": "Definition: SLC16A1 gene described as human SLC16A1 wild-type allele is located in the vicinity of 1p12 and is approximately 45 kb in length. This allele, which encodes monocarboxylate transporter 1 protein, plays a role in the transport of monocarboxylates across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect and hyperinsulinemic hypoglycemia, familial, 7.", + "output": "SLC16A1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: regulation of cellular component organization described as any process that modulates the frequency, rate or extent of membrane invagination.", + "output": "regulation of membrane invagination (regulation of cellular component organization)" + }, + { + "input": "Definition: something described as stage I includes: Any T, Any N, M0. M0: No distant metastasis.", + "output": "Stage I Thyroid Gland Papillary Cancer Under 55 Years (Neoplastic Process)" + }, + { + "input": "Definition: Malignant neoplasm of pelvis described as sarcoma involving the organs and structures of the pelvis.", + "output": "Sarcoma of pelvis (Sarcoma)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 (NCCN-FACT FOSI-18 Version 2) I feel fatigued.", + "output": "FAC050-I Feel Fatigued (Intellectual Product)" + }, + { + "input": "Definition: Spatial Concept described as physical location of ADORA2A_Gene", + "output": "22: 23153646-23162879 (Spatial Concept)" + }, + { + "input": "Definition: Disorder of lipoprotein AND/OR lipid metabolism described as conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.", + "output": "lipidoses (Disorder of lipoprotein AND/OR lipid metabolism)" + }, + { + "input": "Definition: Pathologic Function described as a disease state that refers to a limited number of clinically detectable metastases, an intermediate state between purely localized disease and widespread metastases.", + "output": "Oligometastasis (Neoplasm Metastasis)" + }, + { + "input": "Definition: something described as stents designed for deployment into the larynx to prevent opposing mucosal surfaces from touching, instead of providing 360 degrees of support as most stents do. These stents typically consist of a silicone (either clear or radiopaque) tube often with a wide T configuration, but some other keels resemble an umbrella; the stents are available in several sizes. Keel stents are mainly intended to prevent the laryngeal web from reforming; they are frequently used in children with congenital laryngeal web or laryngeal stenosis (i.e., atresia), to repair anterior glottis stenosis, and to prevent stenosis after hemilaryngectomy.", + "output": "Stents, Laryngeal, Keel (Implants)" + }, + { + "input": "Definition: something described as the reemergence of a disorder as diagnosed by clinical and/or laboratory evidence following three documented periods of remission.", + "output": "Third Relapse (Subsequent Relapse)" + }, + { + "input": "Definition: Intellectual Product described as a document that describes the data standardization strategy for clinical and nonclinical studies within a development program. NOTE: A Study Data Standardization Plan is intended to include historical, current, and planned information about the use of study data standards for studies to conform with the current technical formats, and terminologies described in the FDA Data Standards Catalog which applies to CDER, CBER, and CDRH. [After http://www.phusewiki.org/wiki/images/e/ea/SDSP_Template.pdf, https://www.fda.gov/industry/fda-resources-data-standards/study-data-standards-resources, https://www.fda.gov/media/102719/download] See also standards, data standards, CDISC standards, and Standards Development Organization.", + "output": "SDSP (Planned)" + }, + { + "input": "Definition: Bladder Urachal Urothelial Carcinoma described as bladder urachal urothelial carcinoma that has spread to another anatomic site.", + "output": "Metastatic Bladder Urachal Urothelial Carcinoma (Metastatic Bladder Urothelial Carcinoma)" + }, + { + "input": "Definition: Cell described as a preparation of natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon infusion of the therapeutic iNKTs, these cells recognize CD1d-restricted lipid ligands, which are expressed on certain tumor cells, and secrete large amounts of various cytokines. This may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells.", + "output": "therapeutic invariant natural killer T cells (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as a species of aerobic, Gram negative, cocci shaped bacteria assigned to the phylum Proteobacteria. This species is oxidase and catalase positive, does not reduce nitrate and is negative for urea and lysine hydrolysis. M. oblonga has been isolated from the oral cavity of a sheep.", + "output": "MORAXELLA OBLONGA (Bacterium)" + }, + { + "input": "Definition: Abnormality of the orbital region described as a hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the orbital region. []", + "output": "Hamartoma of the orbital region (Neoplastic Process)" + }, + { + "input": "Definition: Hydrolase described as (Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.", + "output": "Pyruvate dehydrogenase lipoamide-phosphatase (Enzyme)" + }, + { + "input": "Definition: something described as the practice of nursing by a registered or licensed nurse to care for a specific patient in a health facility or in the home.", + "output": "Private Duty Nursing (Health Care Activity)" + }, + { + "input": "Definition: Quantitative Concept described as an arbitrary unit of substance concentration expressed in unit(s) per centiliter.", + "output": "Unit per Centiliter (Quantitative Concept)" + }, + { + "input": "Definition: Streptococcus described as a species of Gram positive, cocci shaped, lactic acid bacteria assigned to the phylum Firmicutes. This species is nonmotile, catalase negative, nonsporulating and produces lactic acid from lactose fermentation. L lactis may be an opportunistic pathogen in humans and animals. Most significantly this microorganism is used commercially in the production of buttermilk and cheese.", + "output": "Bacterium lacti (Streptococcus)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone.", + "output": "F420H2-dependent quinone oxidoreductase activity (oxidoreductase activity)" + }, + { + "input": "Definition: transferase activity, transferring aldehyde or ketonic groups described as catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate.", + "output": "macrophomate synthase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a clinical nurse specialist that provides a high level of supportive and therapeutic care to cancer patients and their families. The ONS is an excellent resource for current trends in cancer care and therapies.", + "output": "Physician Assistants & Advanced Practice Nursing Providers; Clinical Nurse Specialist; Oncology (Clinical Nurse Specialists)" + }, + { + "input": "Definition: Document type described as documentation of recognition and approval by an authorized accrediting body applying known acceptable standards, that the facility is competent to perform required test(s), and support reliability of results.", + "output": "Lab Qualifications (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as plunger syringes designed with a nonconcentric (i.e., eccentric) Luer-lock male fitting (tip). These syringes provide a connection with other medical devices, typically a needle, that is almost flush with the side of the barrel.", + "output": "Syringes, Plunger, Luer Lock, Eccentric Tip (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Did {S} talk about the content of a program within a day (24 hours) after watching it?", + "output": "ADL03-Talk About TV Content Within a Day (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: Neoplastic Process described as an oligodendroglioma occuring during adulthood. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4014\" active clinical trials using this agent.", + "output": "CNS tumor, oligodendroglioma, adult (Adult Oligodendroglial Tumor)" + }, + { + "input": "Definition: Intellectual Product described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Did you feel tired?", + "output": "MSQL131 (Intellectual Product)" + }, + { + "input": "Definition: African American described as a person having origins in any of the original peoples of Barbados.", + "output": "Barbadian race (Population Group)" + }, + { + "input": "Definition: rotation irradiation described as a type of external beam radiation therapy in which the radiation is delivered slice-by-slice, providing sequential delivery of radiation to different parts of the tumor. This method differs from other forms of radiation therapy in which the entire tumor volume is irradiated at one time.", + "output": "helical tomotherapy (Therapeutic radiology procedure)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.", + "output": "mykose metabolic process (disaccharide metabolic process)" + }, + { + "input": "Definition: something described as international Physical Activity Questionnaire (August 2002) Long Last 7 Days Self-Administered Format (IPAQ Long Last 7 Days Self-Administered Format Version) During the last 7 days, on how many days did you walk for at least 10 minutes at a time to go from place to place?: No walking from place to place.", + "output": "IPA0312B (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of miRNA catabolic process.", + "output": "positive regulation of miRNA catabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as this gene is thought to play a role in insulin regulation; however, the exact function is not known.", + "output": "INSRR Gene (Receptor Tyrosine Kinase Gene)" + }, + { + "input": "Definition: Biomedical or Dental Material described as sterile preparation consisting of a gas that is intended to be mixed with the specified liquid to obtain a dispersion of the gas in the liquid, which is intended for administration by infusion.", + "output": "Gas for Dispersion for Infusion Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Finding described as faint erythema or dry desquamation", + "output": "Grade 1 Radiation Recall Reaction (Dermatologic), CTCAE (Radiation Recall Reaction (Dermatologic), CTCAE)" + }, + { + "input": "Definition: something described as catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH.", + "output": "meso-tartrate:NAD+ oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as an Afro-Asiatic language, belonging to the Highland East Cushitic branch of the Cushitic family spoken in parts of southern Ethiopia by the Sidama people.", + "output": "Sidamo (Cushitic language)" + }, + { + "input": "Definition: Intellectual Product described as identification, quality, and potency of chemicals and drugs to meet standards set by the government or industry; includes the development, testing, and application of standards of adequacy or acceptable performance.", + "output": "chemical standardization (Intellectual Product)" + }, + { + "input": "Definition: something described as the directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface.", + "output": "cutin transport (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.", + "output": "Zinc Finger and BTB Domain Containing 16 Protein (Biologically Active Substance)" + }, + { + "input": "Definition: C [Preparations] described as a species of MITOSPORIC FUNGI and opportunistic pathogen associated with its ability to form BIOFILMS in catheters and parenteral nutrition IV lines. C. parapsilosis complex includes closely related species C. orthopsilosis; and C. metapsilosis.", + "output": "Mycocandida parapsilosis (C [Preparations])" + }, + { + "input": "Definition: Unspecified disorders of arteries and arterioles described as a vascular disorder characterized by thickening and hardening of the walls of the arteries.", + "output": "Arteriosclerosis (Physical & Psychosomatic Disorders)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.", + "output": "CHEM WATER POLLUTANTS (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as a drug that has been given by mouth in the treatment of atherosclerosis and other vascular disorders, hyperlipidemias, and thrombo-embolic disorders.", + "output": "Pyricarbate (Antilipidemic Agent)" + }, + { + "input": "Definition: Quantitative Concept described as oral intake of foods that have been modified for a nutrition purpose, for example lactose free, gluten free, sugar free, low fat, nut free.", + "output": "Special dietary food intake (Nutrient Intake)" + }, + { + "input": "Definition: something described as minutes times milligrams per milliliter (area under the curve), divided by meters squared (surface area).", + "output": "Minute Times Milligram per Milliliter per Meter Squared (Measurement Unit Description)" + }, + { + "input": "Definition: something described as an indication that cells that are expressing the peptide/major histocompatibility protein complex (pMHC) comprised of a minor histocompatibility peptide antigen (HA-1) bound to HLA-A*0201 are present in a sample.", + "output": "HLA-A*02:01 HA-1 Positive Cells Present (Laboratory or Test Result)" + }, + { + "input": "Definition: Finding described as an electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate.", + "output": "Electrocardiogram atrioventricular block complete heart block (electrocardiogram: atrioventricular block)" + }, + { + "input": "Definition: Testosterone Congeners described as a steroid metabolite derived from sex hormones, which displays weak androgenic properties. In testes is formed from progesterone. Androsterone sulfate is clinically recognized as one of the major androgen metabolites found in urine, in males and females. It is made in the liver from the metabolism of testosterone. Androsterone glucuronide, a dihydrotestosterone metabolite, is present in serum. Androsterone is a weak anabolic hormone.", + "output": "3 alpha Hydroxy 5 alpha Androstan 17 One (Androgens)" + }, + { + "input": "Definition: Agent Affecting Digestive System or Metabolism described as oral therapeutic agent that counteracts acidity.", + "output": "anti-ulcer drugs (Gastrointestinal Agents)" + }, + { + "input": "Definition: something described as acute Physiology and Chronic Health Evaluation II (APACHE II) A: Total acute physiology score.", + "output": "APCH113 (APACHE II Clinical Classification Question)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - I am able to concentrate.", + "output": "FAC061-I Am Able to Concentrate (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as the Overactive Bladder Questionnaire - Caused you to plan activities more carefully?", + "output": "OABQ01-Plan Activities More Carefully (OAB-q Questionnaire Question)" + }, + { + "input": "Definition: Congenital anomalies of eyelid, lacrimal system and orbit described as a congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.", + "output": "Congenital ankyloblepharon (Ankyloblepharon)" + }, + { + "input": "Definition: Laboratory Procedure described as an in vitro assay that is used to determine whether antibodies that can block viral infection are present in a biological specimen. Virus is mixed with serum taken from the subject and is incubated in culture with laboratory cells, which are monitored over time for cytotoxicity.", + "output": "Virus Neutralization Assay (Laboratory Procedure)" + }, + { + "input": "Definition: Gene or Genome described as human RAP1A wild-type allele is located in the vicinity of 1p13.3 and is approximately 174 kb in length. This allele, which encodes Ras-related protein Rap-1A, is involved in the suppression of the mitogenic activity of Ras family GTPases.", + "output": "KREV-1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a synthetic steroid that has anabolic and androgenic properties.", + "output": "STANOZOLOL (Androgens, Synthetic)" + }, + { + "input": "Definition: Peptide hormones and their metabolites and precursors described as a kind of gastrointestinal hormone", + "output": "GIP (Incretins)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as MIR128-1 is an oligoribonucleotide that is encoded by the human MIR128-1 gene and has a role in the regulation of gene expression.", + "output": "MIR128-1 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Temporal Concept described as the actual time that is one minute after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test.", + "output": "One Minute After Birth (Temporal Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as a viral infection caused by any of the arboviruses of the Togaviridae family. It is transmitted by arthropods. Signs and symptoms include fever, headache, nausea, vomiting, rash, confusion, and seizures.", + "output": "TOGAVIRIDAE INFECT (Disease or Syndrome)" + }, + { + "input": "Definition: Immunologic Factor described as a human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine overexpressed in some cancers, plays a key role in inflammation, immune responses and cancer cell proliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C104260\" active clinical trials using this agent.", + "output": "Immunoglobulin g1-kappa, anti-(homo sapiens mif (macrophage migration inhibitory factor, glycosylation-inhibiting factor, glif, gif)), homo sapiens monoclonal antibody (Immunologic Factor)" + }, + { + "input": "Definition: Family history described as a history of a first-degree relative that has had syncope.", + "output": "Family history of syncope (FH: Cardiovascular disease)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.", + "output": "mitochondrial RNA metabolic process (Genetic Function)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version (C-SSRS Lifetime/Recent Version) Total number of actual attempts. (Lifetime).", + "output": "CSS1113A (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: Embryonic Structures described as a mammalian fetus expelled by INDUCED ABORTION or SPONTANEOUS ABORTION.", + "output": "Aborted Embryos (Other Anatomic Concept)" + }, + { + "input": "Definition: Organ or Tissue Function described as the progression of the right horn of the sinus venosus from its formation to the mature structure.", + "output": "right horn of sinus venosus development (Organ or Tissue Function)" + }, + { + "input": "Definition: serine family amino acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.", + "output": "cysteine formation (sulfur amino acid biosynthetic process)" + }, + { + "input": "Definition: something described as a measurement of the basophilic myelocytes in a biological specimen.", + "output": "BASOMYL (White Blood Cell Count procedure)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+.", + "output": "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Enzyme described as regulator of telomere elongation helicase 1 (1219 aa, ~134 kDa) is encoded by the human RTEL1 gene. This protein plays a role in the maintenance of chromosomes and telomeres.", + "output": "RTEL1 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Synovial Cyst described as a fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle.", + "output": "knee cyst popliteal (DISORDERS OF THE SYNOVIA, TENDONS AND BURSAE INCLUDING ENTHESOPATHIES)" + }, + { + "input": "Definition: Eukaryote described as class of Arthropoda in the subphylum Myriapoda which comprises centipedes and millipedes. Chilopoda or centipedes are characterized by long multi-segmented bodies each segment with a pair of legs. Most centipedes are predatory and venomous. While centipede bites typically only cause pain, irritation and allergic reactions they sometimes cause acute HYPERTENSION and MYOCARDIAL ISCHEMIA.", + "output": "Centipedes (Eukaryote)" + }, + { + "input": "Definition: fluid flow described as translocation of water.", + "output": "flow water (fluid flow)" + }, + { + "input": "Definition: arginine metabolic process described as the chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine.", + "output": "putrescine biosynthetic process from arginine (putrescine biosynthetic process)" + }, + { + "input": "Definition: Phylum Amoebozoa described as a genus of free-living amoebae found in fresh water. The cysts usually pass harmlessly through the intestinal tract of man and may thus be found in feces. Occasionally, these organisms cause respiratory tract infections or generalized fatal meningoencephalitis.", + "output": "Hartmannella species (Phylum Amoebozoa)" + }, + { + "input": "Definition: Renal Reabsorption described as a renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.", + "output": "nephron sodium ion absorption (Renal Reabsorption)" + }, + { + "input": "Definition: Cutaneous dose form described as liquid or, occasionally, semi-solid, usually multidose preparation intended for application to the scalp by rubbing and subsequent washing away with water. Upon rubbing with water, shampoos usually form foam. Shampoos are solutions, suspensions or emulsions containing surface-active agents.", + "output": "Shampoo Dosage Form (Topical Dosage Form)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - In the past 4 weeks, did {S} drive a car?", + "output": "ADCS-ADL MCI - Drive a Car (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as surgical bone drill bits designed to perforate the cranium when held and revolved by a rotary device (e.g., a surgical handpiece) that are capable of cutting straight down into the cranium and then move laterally to make slots. These devices typically consist of a cylindrical shank of steel or other hard metal with a uniform cross-section. They include a working end with fluted cutting edges that include at least a pair of opposite cutting teeth that allow cutting slots in the skull, and a notched or elongated proximal end to fit into the rotary device. Slot craniotomy drill bits are used mainly to cut cranium flaps that are usually replaced after intracranial surgery.", + "output": "Drill Bits, Surgical, Craniotomy, Slot (Drill Bits, Surgical, Craniotomy)" + }, + { + "input": "Definition: something described as a coded value specifying a classification.", + "output": "categoryCode (Intellectual Product)" + }, + { + "input": "Definition: Parasitic encephalitis described as infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION.", + "output": "Toxoplasmosis of brain (Infectious Encephalitis)" + }, + { + "input": "Definition: Caribbean Islands described as the name of two islands of the West Indies, separated by a narrow channel. Their capital is Basse-Terre. They were discovered by Columbus in 1493, occupied by the French in 1635, held by the British at various times between 1759 and 1813, transferred to Sweden in 1813, and restored to France in 1816. Its status was changed from colony to a French overseas department in 1946. Columbus named it in honor of the monastery of Santa Maria de Guadalupe in Spain.", + "output": "GUADELOUPE (Country)" + }, + { + "input": "Definition: progesterone receptor negative described as an immunohistochemical result of 0 for progesterone receptor expression that is considered negative for expression.", + "output": "PgR IHC 0 (progesterone receptor negative)" + }, + { + "input": "Definition: kinase activity described as catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).", + "output": "glycerophosphate kinase activity (phosphotransferase activity, carboxyl group as acceptor)" + }, + { + "input": "Definition: Health Care Related Organization described as includes all inpatient stays, including: same-day hospital discharges, hospital transfers, and acute hospital care where the discharge is after the admission date.", + "output": "Inpatient hospital (Place of Service Codes for Professional Claims)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).", + "output": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity (carbon-carbon lyase activity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a limb, organ, or other portion of a biologic entity. EXAMPLE(S): he left kidney of a person, a dog's right from paw, a patch of skin on a person's left forearm", + "output": "Biologic Entity Part (Part)" + }, + { + "input": "Definition: Intellectual Product described as a work that is a veterinary clinical study in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions.", + "output": "Clinical Trial, Veterinary (Intellectual Product)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a lactic acid test system is a device intended to measure lactic acid in whole blood and plasma. Lactic acid measurements that evaluate the acid-base status are used in the diagnosis and treatment of lactic acidosis (abnormally high acidity of the blood).", + "output": "ACID, LACTIC, ENZYMATIC METHOD (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Inflammatory dermatosis described as a skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).", + "output": "Acnes (Diseases Component)" + }, + { + "input": "Definition: Dilator described as a vaginal stent is a device used to enlarge the vagina by stretching, or to support the vagina and to hold a skin graft after reconstructive surgery.", + "output": "Dilators, Vaginal (Dilator)" + }, + { + "input": "Definition: Disease or Syndrome described as a group of hearing disorders characterized by impaired transmission of signal through the auditory nerve with abnormal or absent auditory brainstem response with hearing loss and poor speech perception.", + "output": "Auditory neuropathy spectrum disorder (Vestibulocochlear Nerve Diseases)" + }, + { + "input": "Definition: Measurement finding above reference range described as the amount of prostate specific antigen is increased, based on pre-defined thresholds.", + "output": "PSA Progression (Clinical finding present)" + }, + { + "input": "Definition: something described as an abnormality of a nucleobase metabolic process.", + "output": "Abnormal circulating nucleobase concentration (Finding)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a molecular genetic abnormality that refers to the presence of a mutation in the ETV6 gene (ETS variant gene 6).", + "output": "ETV6 Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: something described as immunology reagents including monoclonal antibodies that are used in immunologic tests for typing T lymphocytes by identifying their antigens (e.g., CD2, CD3, CD4, CD8). Frequently cells bearing the CD4+ receptor are termed helper cells and those with the CD8+ receptor are termed suppressor T cells. T-lymphocytes are typically associated with cellular immunity and are also involved in humoral immunity. These tests permit the differentiation between polyclonal processes and monoclonal neoplasms and also contribute in the classification among different types of lymphoid neoplasms. The ratio of CD4+/CD8+ is used in the diagnosis and monitoring of AIDS; an increase in this ratio is also considered an early indicator in the diagnosis of transplanted organ rejection.", + "output": "IVD Test Reagent/Kits, Immunoassay, Immunology, Cell Typing, Monoclonal Antibody, T Cell (IVD Test Reagent/Kits, Immunoassay, Immunology, Cell Typing, Monoclonal Antibody)" + }, + { + "input": "Definition: Mass conditions NEC described as a tumor-like collection of serum in the tissues.", + "output": "seromas (Pathologic Function)" + }, + { + "input": "Definition: something described as this gene plays a role in leukocyte activation and immune function.", + "output": "CD244 natural killer cell receptor 2B4 (Gene or Genome)" + }, + { + "input": "Definition: something described as feeling friendly, kind, or good-natured.", + "output": "Pleasant (Mental Process)" + }, + { + "input": "Definition: something described as one of two parts of the thoracic column in the rat. The other is the rostral part of the thoracic column ( Swanson-2004 ).", + "output": "dorsal nucleus of the spinal cord, caudal part (Clarke's Nucleus)" + }, + { + "input": "Definition: organophosphate metabolic process described as the chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.", + "output": "deoxyribose phosphate metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as wings apart-like protein homolog (1190 aa, ~133 kDa) is encoded by the human WAPL gene. This protein is involved in meiosis, mitosis and DNA replication.", + "output": "Wings Apart-Like Protein Homolog (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: secretion by tissue described as a reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.", + "output": "milk ejection reflex (Reflex motion descriptor)" + }, + { + "input": "Definition: something described as a substance produced by attaching glucuronic acid to another substance with glycosidic bonds.", + "output": "glucuronide (Glycosides)" + }, + { + "input": "Definition: Organic Chemical described as an immunoradioconjugate containing metuximab, an antibody fragment targeting the hepatocellular cancer (HCC)-associated antigen HAb18G/CD147, that is conjugated to the radioisotope iodine I 131, with potential antineoplastic activity. Upon administration, the metuximab moiety of licartin targets and binds to HAb18G/CD147 on HCC cells; upon internalization, the radioisotope I 131 delivers a cytotoxic dose of gamma radiation, thereby causing selective destruction of HAb18G/CD147-expressing cells. HAb18G/CD147, a member of CD147 family, is overexpressed in HCC and fibroblasts and its expression is associated with cancer cell progression and increased adhesion, invasion and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C104275\" active clinical trials using this agent.", + "output": "licartin (Pharmacologic Substance)" + }, + { + "input": "Definition: tube development described as the process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes.", + "output": "S1 development (tube development)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.", + "output": "UDP-glucose 6-dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Skull Neoplasms described as a benign or malignant neoplasm that affects the orbit.", + "output": "Tumor of orbit (Ocular neoplasms malignancy unspecified)" + }, + { + "input": "Definition: Ventricular Arrhythmia by ECG Finding described as an electrocardiographic finding of a non-specific abnormality of the QRS complex, which is atypical in shape, duration, amplitude, axis or polarity.", + "output": "QRS Complex Abnormality by ECG Finding (Ventricular Arrhythmia by ECG Finding)" + }, + { + "input": "Definition: FACT/GOG-NTX Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity Version 4 (FACT/GOG-NTX Version 4) Social/Family Well-Being: I get emotional support from my family.", + "output": "FACT/GOG-NTX Version 4 - Get Emotional Support From Family (Intellectual Product)" + }, + { + "input": "Definition: LIMK2 gene described as human LIMK2 wild-type allele is located in the vicinity of 22q12.2 and is approximately 68 kb in length. This allele, which encodes LIM domain kinase 2 protein, plays a role in serine/threonine phosphorylation.", + "output": "LIMK2 wt Allele (LIMK2 gene)" + }, + { + "input": "Definition: something described as human FLOT2 wild-type allele is located within 17q11-q12 and is approximately 18 kb in length. This allele, which encodes flotillin 2 protein, is involved in the maintenance of caveolae structure, cellular adhesion and neuronal signaling. The determination of the level of the expression of the wild-type allele may be utilized to characterize early carcinogenesis.", + "output": "ECS-1 (FLOT2 gene)" + }, + { + "input": "Definition: Rare Non-Neoplastic Disorder described as a rare autosomal recessive inherited metabolic disorder caused by deficiency of the enzyme glutaryl-CoA dehydrogenase. It is characterized by abnormalities in the metabolism of lysine, hydroxylysine, and tryptophan that result in the accumulation and urinary excretion of glutaric acid. Patients present with brain atrophy, microcephaly, and acute dystonia.", + "output": "glutaric aciduria type i (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as the Hamilton Depression Rating Scale 6 Self-Report Version (HAM-D6 - Self-Report Version) (Clinical Research: Rating scales in depression: limitations and pitfalls; Per Bech, MD; Copyright 2006 LLS SAS. All rights reserved).", + "output": "HAMDS1 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 3 Months Version - These are more questions about your cough and shortness of breath these days: Coughing hurts.", + "output": "SGRQ0119 (Intellectual Product)" + }, + { + "input": "Definition: Quantitative Concept described as days times femtograms per milliliter (area under the curve), divided by kilograms per meter squared (body mass index).", + "output": "d.fg/mL/(kg/m2) (Quantitative Concept)" + }, + { + "input": "Definition: something described as acetyl-CoA is produced in mitochondria through the metabolism of fatty acids and the oxidation of pyruvate to acetyl-CoA. When ATP is needed, this acetyl-CoA can enter the Krebs cycle to drive oxidative phosphorylation. When ATP supplies are abundant, the acetyl-CoA can be diverted to other purposes like energy storage in the form of fatty acids. The biosynthesis of fatty acids from this acetyl-CoA cannot take place directly however, since it is produced inside mitochondria while fatty acid biosynthesis occurs in the cytosol. Also, there is not a mechanism that directly transports acetyl-CoA out of mitochondria. To be transported, the acetyl-CoA must be chemically converted to citric acid using a pathway called the tricarboxylate transport system. Inside mitochondria, the enzyme citrate synthase joins acetyl-CoA with oxaloacetate to make citrate. This citrate is transported from the mitochondria to the cytosol, thus transporting the acetyl-CoA in the form of citrate. Once in the cytosol, the citrate is converted back to oxaloacetate, which is then reduced to malate. Malate can be oxidized to pyruvate by the malic enzyme, with production of NADPH as well, that can contribute to fatty acid biosynthesis. Pyruvate can be reimported back into the mitochondria. Alternatively, malate can be transported itself back into the mitochondria and used to produce NADH once inside mitochondria.", + "output": "Acetyl Group Shuttle Pathway (Energy Metabolism Pathway)" + }, + { + "input": "Definition: something described as the etiologic agent of murine typhus (see TYPHUS, ENDEMIC FLEA-BORNE).", + "output": "Rickettsia mooseri (Rickettsia, typhus group)" + }, + { + "input": "Definition: Kidney Cancer Pathologic Primary Tumor TNM Finding v8 described as kidney cancer in which the primary tumor cannot be assessed.", + "output": "Kidney Carcinoma pTX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Clinical Attribute described as the decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA.", + "output": "Spreading Depressions, Cortical (Clinical Attribute)" + }, + { + "input": "Definition: Cellulomonas described as a species of aerobic, Gram-positive, rod shaped bacteria assigned to the phylum Actinobacteria. This species is yellow with extensively branched vegetative hyphae without an aerial mycelium which breaks into motile rod shaped elements, is catalase positive, reduces nitrate, hydrolyzes casein, gelatin and starch, is not acid-fast, mesophilic, utilizes acetate, lactate, and pyruvate. O. turbata is found in soil and rarely causes infections in humans.", + "output": "Cellulomonas turbata [Ambiguous] (Oerskovia)" + }, + { + "input": "Definition: Neoplastic Process described as a rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation.", + "output": "Thymic Adenocarcinoma (Adenocarcinoma)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - Could the subject use the telephone without help?", + "output": "UHDR154 (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: United States described as the geographic area of the southwestern region of the United States. The states usually included in this region are Arizona, California, Colorado, Nevada, New Mexico, Texas, and Utah.", + "output": "Southwestern United States (United States)" + }, + { + "input": "Definition: something described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to pairing events.", + "output": "PA (Domain)" + }, + { + "input": "Definition: Antibiotic described as a semi-synthetic, third-generation cephalosporin antibiotic with a narrow spectrum of activity. Cefsulodin has activity against Pseudomonas aeruginosa and Staphylococcus aureus but little activity against other bacteria.", + "output": "Cefsulodin (Antibiotics)" + }, + { + "input": "Definition: HealthcareProviderTaxonomyHIPAA - CodeSystem described as an individual, often licensed by the state, who is responsible for the management of a nursing home.", + "output": "Nursing Home Administrator (HealthcareProviderTaxonomyHIPAA - CodeSystem)" + }, + { + "input": "Definition: Ostium described as an opening in the hip bone formed by the public bone and the ischium and closed by the obturator membrane.", + "output": "Foramen obturatorium (Body Space or Junction)" + }, + { + "input": "Definition: PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 60 above, was your child's activity limited by: Doctor or parent instructions?", + "output": "PODCI2-Friends Limited by: Instructions (Intellectual Product)" + }, + { + "input": "Definition: something described as a type of congenital cataract in which the opacity follows the anterior or posterior Y suture.", + "output": "Sutural cataract (Disease or Syndrome)" + }, + { + "input": "Definition: Dilatation and Curettage described as dilatation of the cervix uteri followed by a scraping of the endometrium with a curette.", + "output": "Dilatation & curettage (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of pendant.", + "output": "Pendant (Potency Unit)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of early endosome to late endosome transport.", + "output": "regulation of early endosome to late endosome transport (regulation of cytoplasmic transport)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen.", + "output": "anaerobic phenol-containing compound metabolism (phenol-containing compound metabolic process)" + }, + { + "input": "Definition: Medical Device described as particulate air filters designed to remove very fine particulate from the air, typically 99.97% of particles larger than 0.3 micron. These filters usually consist of pleats of filter medium separated by rigid sheets of corrugated paper or aluminum foil; most high efficiency particulate air (HEPA) filters direct the flow of air in a uniform parallel pattern (laminar flow). HEPA filters are used to obtain very low particulate environments in places such as clean rooms, patient isolation chambers, and laminar air hoods; they are also used in high efficiency air cleaners. High-efficiency particulate air filters can remove most aerosolized biological agents and radioactive particles.", + "output": "High-Efficiency Particulate Air Filters (Medical Device)" + }, + { + "input": "Definition: Class II antiarrhythmic agent described as the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Acebutolol acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.", + "output": "Acebutolol hydrochloride (Cardiovascular Agents)" + }, + { + "input": "Definition: regulation of systemic arterial blood pressure mediated by a chemical signal described as the regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.", + "output": "regulation of blood pressure by noradrenaline (Molecular Function)" + }, + { + "input": "Definition: Central Nervous System described as loss of previously present motor (i.e., movement) abilities.", + "output": "Motor deterioration (Finding)" + }, + { + "input": "Definition: something described as scan without any subject or attenuating material, but with a source, present.", + "output": "Blank Scan (Health Care Activity)" + }, + { + "input": "Definition: Virus Diseases described as an acute, infectious tropical disease caused by an arbovirus transmitted by mosquitoes", + "output": "Dengue Fever (Hemorrhagic Fevers, Viral)" + }, + { + "input": "Definition: something described as a finding of no visible posterior motion of tongue base during swallowing.", + "output": "No Visible Posterior Motion of Tongue Base During Swallowing (Finding)" + }, + { + "input": "Definition: something described as equipment designed to grind the edges of eyeglass lenses to improve fitting to the eyeglass frame. This equipment frequently consists of an automated grinding machine that includes lens holders, grinding and/or polishing wheels, a water supply unit to cool the lens, a scanner to scan and obtain the shape of the eyeglass frame, and a control and data display unit. Manually operated stone grinding wheels are also available. Eyeglass lens edgers are capable of shaping eyeglass lens edges into particular forms, such as flat, grooved, or beveled.", + "output": "Lens Edgers, Eyeglass (Medical Device)" + }, + { + "input": "Definition: negative regulation of cytokine secretion described as any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.", + "output": "negative regulation of interleukin-10 secretion (negative regulation of interleukin-10 production)" + }, + { + "input": "Definition: PLACENTA AND MEMBRANES described as the fluid within the amniotic cavity which surrounds and protects the developing embryo.", + "output": "Waters (embryo and fetus)" + }, + { + "input": "Definition: Extensor of shoulder joint described as intrinsic muscle of shoulder which attaches to acromion and spine of scapula, clavicle and humerus.", + "output": "Deltoid (Deltoid region)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) Please check one box for each question: I have shortness of breath.", + "output": "SGRQ-C - Have Shortness of Breath (Intellectual Product)" + }, + { + "input": "Definition: Filling Problem described as insufficient filling of a device. For complete failure to fill use \"inability to auto-fill\". For insufficient filling use \"short fill\". For inconsistent filling - use \"Volume Accuracy Problem\".", + "output": "Short Fill (Filling Problem)" + }, + { + "input": "Definition: something described as a knee joint femorotibial metallic constrained cemented prosthesis is a device intended to be implanted to replace part of a knee joint. The device prevents dislocation in more than one anatomic plane and has components that are linked together. The only knee joint movement allowed by the device is in the sagittal plane. This generic type of device includes prostheses that have an intramedullary stem at both the proximal and distal locations. The upper and lower components may be joined either by a solid bolt or pin, an internally threaded bolt with locking screw, or a bolt retained by circlip. The components of the device are made of alloys, such as cobalt-chromium-molybdenum. The stems of the device may be perforated, but are intended for use with bone cement (Sec. 888.3027).", + "output": "Prostheses, Knee, Hinged (Medical Device)" + }, + { + "input": "Definition: Entner-Doudoroff pathway described as a pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.", + "output": "Entner-Doudoroff pathway through 6-phosphogluconate (Molecular Function)" + }, + { + "input": "Definition: something described as physical location of HDAC2_Gene", + "output": "6: 114398967-114368621 (Spatial Concept)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.", + "output": "nucleoside-diphosphate kinase activity (phosphotransferase activity, phosphate group as acceptor)" + }, + { + "input": "Definition: Abnormality of the epiphysis of the proximal phalanx of the hallux described as failure to form (agenesis) of the epiphysis of the proximal phalanx of the hallux.", + "output": "Absent epiphysis of the proximal phalanx of the hallux (Abnormality of the epiphysis of the proximal phalanx of the hallux)" + }, + { + "input": "Definition: Immunologic Factor described as a multi-epitope vaccine containing the following six class II MHC-restricted peptides: gp100, MelanA/MART-1, two tyrosinase peptides, and the cancer/testis antigens MAGE-A3 and MAGE-A1,2,3,6, with potential antineoplastic activity. Upon administration, melanoma helper peptides induce an antigen-specific, Th1-dominant, CD4+ T-cell response, potentially augmenting cytotoxic T-cell (CTL) responses and maintaining immunologic memory against tumor cells expressing melanoma-specific antigens. The 6MHP vaccine may also induce a CD8+ T-cell response through epitope spreading, potentially priming subsequent immune responses against tumor cells.", + "output": "6 Melanoma Helper Peptide Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a rare clinical variant of epidermolytic ichthyosis, with manifestations of blistering phenotype at birth and the development from early infancy of annular polycyclic erythematous scales on the trunk and extremities. It has been reported in less than 10 families. The disease is caused by mutations in the KRT1 (12q11-q13) and KRT10 (17q21-q23) genes, encoding keratins 1 and 10 respectively. These mutations impair keratin filament formation and weaken the structural stability of the keratinocyte cytoskeleton. Transmission is autosomal dominant.", + "output": "Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Pass-Throughs, Enclosed described as enclosed pass-throughs designed to exchange x-ray film cassettes to and from the darkroom without radiation light entering. These pass-throughs typically consist of metallic structures with a lead linen to provide x-ray shielding; they are typically wall mounted and include automated interlocks that close one door when the opposite is opened. X-ray enclosed pass-throughs are also used for temporary storage of loaded cassettes isolated from the radiation source.", + "output": "Cabinets, X-Ray Transfer (Medical Device)" + }, + { + "input": "Definition: Congenital abnormality of cardiac ventricle described as aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left ventricular cavity.", + "output": "Aortico Left Ventricular Tunnel (Disorder of left cardiac ventricle)" + }, + { + "input": "Definition: Finding described as an abnormality of the concentration of glucose in the urine.", + "output": "Abnormality of urine glucose concentration (Finding)" + }, + { + "input": "Definition: Spastic paraplegia type 5A, recessive described as a very rare complex type of hereditary spastic paraplegia with characteristics of early-onset spastic paraplegia (with spasticity in the lower extremities that progresses to the upper extremities) associated with developmental and motor delay, mild to moderate cognitive and speech delay, skeletal dysmorphism (e.g. kyphosis and pectus), hypertrichosis and mildly impaired vibration sense. Caused by mutations in the VPS37A gene (8p22) encoding vacuolar protein sorting-associated protein 37A.", + "output": "Autosomal recessive spastic paraplegia type 53 (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.", + "output": "lymphocyte adhesion to endothelial cell of high endothelial venule (leukocyte adhesion to vascular endothelial cell)" + }, + { + "input": "Definition: something described as an application of PHARMACY involving the preparation and dispensing of radioactive materials for use in medications.", + "output": "Pharmacy, Nuclear (Pharmacy)" + }, + { + "input": "Definition: Genetic Function described as steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs.", + "output": "mitochondrial mRNA processing (mitochondrial RNA processing)" + }, + { + "input": "Definition: Neoplasms, Glandular and Epithelial described as a neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium. []", + "output": "neuroepithelial tumor (Neuronal and mixed neuronal-glial tumor)" + }, + { + "input": "Definition: Pharmacologic Substance described as a human single-chain variable fragment of a monoclonal antibody against fungal Hsp90 with anti-fungal activity. Efungumab binds to heat shock protein 90 (Hsp90) located on the fungal cell surface, thereby preventing cell wall synthesis and repair. This decreases the integrity of the fungal cell wall and prevents further fungal cell growth. In addition, as Hsp90 is a molecular chaperone, inhibition of its function may increase the cytotoxic effect of other antifungal agents.", + "output": "efungumab (Immunologic Factor)" + }, + { + "input": "Definition: Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 - I have pain.", + "output": "FAC05002 (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: something described as a liposome-encapsulated formulation of bupivacaine, which is an amide-type, long-acting local anesthetic. Upon administration, bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in both a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization. This leads to inhibition of both depolarization and nerve impulse conduction, and a reversible loss of sensation. Compared to bupivacaine alone, liposomal delivery increases the duration of local anesthetic action and delays the peak plasma concentration of bupivacaine due to its slow release from the liposome. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125652\" active clinical trials using this agent.", + "output": "Liposomal Bupivacaine (Anesthetics)" + }, + { + "input": "Definition: serotonin secretion involved in inflammatory response described as the regulated release of serotonin by a mast cell or group of mast cells.", + "output": "serotonin secretion by mast cell (Intracellular Transport)" + }, + { + "input": "Definition: Reproductive Physiological Phenomena described as a measurement of the total number of live-born offspring a female has delivered.", + "output": "delivery number (# ) (Personal Attribute)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as nucleus of closely packed, deeply staining cells in the ventral part of the periaqueductal gray; a major source of ascending, serotonergic fibers; appear to be important in regulation of sleep.", + "output": "Nucleus Raphe, Dorsal (Set of raphe nuclei)" + }, + { + "input": "Definition: something described as rRNA-processing protein UTP23 homolog (249 aa, ~28 kDa) is encoded by the human UTP23 gene. This protein is involved in rRNA-processing and ribosome biogenesis.", + "output": "C8orf53 (Regulatory Protein)" + }, + { + "input": "Definition: something described as a tool designed to assign allogeneic hematopoietic cell transplantation patients into one of four overall survival (OS) risk groups based on disease type and disease status at the time of transplantation. This index applies regardless of age, conditioning regimen, donor type, and graft source.", + "output": "Disease Risk Index (Intellectual Product)" + }, + { + "input": "Definition: something described as an electronic repository within the US Food and Drug Administration containing subject-level clinical and nonclinical study data submitted to the FDA as part of a regulatory submission.", + "output": "Janus study data repository (Manufactured Object)" + }, + { + "input": "Definition: something described as a coloboma of the ciliary body. []", + "output": "Ciliary body coloboma (Congenital ocular coloboma)" + }, + { + "input": "Definition: Chemical categorised functionally described as a uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.", + "output": "antivirals sofosbuvir (Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor)" + }, + { + "input": "Definition: negative regulation of synapse organization described as any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization.", + "output": "downregulation of terminal button organisation (negative regulation of synapse organization)" + }, + { + "input": "Definition: something described as persons traveling on foot.", + "output": "Pedestrians (Population Group)" + }, + { + "input": "Definition: Electroanalgesia described as a minimally invasive form of electroanalgesia involving stimulation of the dermatomal bands proximal to the affected area. It is often used in the treatment of intractable chronic lower back pain, cancer pain, and other painful disorders.", + "output": "Peripheral Electronic Nerve Stimulation (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Procedure Kit/Trays described as prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for collecting items and/or gathering information related to a crime scene. Items in these kits usually include an appropriate black light lantern, a duster brush, crime-scene tape, a magnifier, gloves, a pipette, peel/stick print folders, cello tape, dusting powder, testing products (e.g., magnesium sulfate, calcium carbonate), and a graphite block. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Forensic evidence procedure kits and trays are used during the investigation of crimes to gather scientific evidence which may be used in legal proceedings. These trays are mainly used in the field and in forensic laboratories.", + "output": "Procedure Kit/Trays, Forensic Evidence (Procedure Kit/Trays)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual's hair is thinning or falling out.", + "output": "Is your hair thinning or falling out (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as abnormal cells are found in tissue lining the inside of the renal pelvis or ureter. These abnormal cells may become cancer and spread into nearby normal tissue. Stage 0 is divided into stages 0a (papillary carcinoma) and 0is (carcinoma in situ), depending on the type of tumor. Stage 0a may look like tiny mushrooms growing from the lining of the renal pelvis or ureter. Stage 0is is a flat tumor on the tissue lining the inside of the renal pelvis or ureter.", + "output": "Stage 0 Renal Pelvis and Ureter Urothelial Carcinoma AJCC v7 (Non-Invasive Urothelial Neoplasm)" + }, + { + "input": "Definition: something described as this gene is involved in lysophospholipid metabolism.", + "output": "LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 4 (Gene or Genome)" + }, + { + "input": "Definition: fowlpox virus vaccine described as a synthetic cancer vaccine derived from a melanoma-associated antigen, MART-1. Antigenic peptides derived from MART-1 are recognized by CD8+ T lymphocytes and have been used to immunize patients with advanced melanomas; prolonged immunization may result in a reduction in tumor size. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues.", + "output": "MART-1 Fowlpox Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: Spinal cord part described as a bundle of neuronal fibers originating in the lumbosacral spinal cord that ascend to the ipsilateral cerebellum conveying proprioceptive information for the lower limbs and joints.", + "output": "Direct Cerebellar Tract (Cell Component)" + }, + { + "input": "Definition: Medical Device described as specimen containers designed for short term storage and/or transportation of urine samples. These containers are available in a variety of sizes, including smaller specimen cups (e.g., 100 mL) to larger containers (e.g., 2.5 L) that support the collection of urine samples over an extended period of time (e.g., 24 hours). The containers are typically made of plastic or glass, and often include graduations (for measuring). Most containers are supplied as sterile, single-use items.", + "output": "Specimen Containers, Urine (Medical Device)" + }, + { + "input": "Definition: something described as a nematode infection due to Ancylostoma species or Necator americanus. Prevalence and species vary by country. The infection is acquired by larval penetration of the skin, which causes intense pruritus (ground itch), and is followed by a pulmonary migratory phase; adult worms reside in the gastrointestinal tract, where feeding can lead to blood loss, iron deficiency anemia, and sometimes nutritional deficiencies.", + "output": "Hookworm Infection (Parasitic infection)" + }, + { + "input": "Definition: something described as power meters designed to measure the power output of ultrasonic equipment. These meters usually measure the power by using an appropriate transducer to detect the ultrasonic pressure; a measuring device such as a mechanical balance or electronic load cell; and a display. Ultrasonic power meters are used to verify the accuracy and/or to calibrate diagnostic (e.g. ultrasonic scanners) and/or therapeutic (e.g., ultrasonic physical therapy units).", + "output": "Power Meters, Ultrasound (Power Meters)" + }, + { + "input": "Definition: Chemistry, Analytic described as the formation of crystalline substances from solutions or melts.", + "output": "crystallization (Chemistry Techniques, Analytical)" + }, + { + "input": "Definition: Nutraceuticals described as perque(TM) Perkies Cherry Raspberry each 90 tablets. UPC Code 791760030504.", + "output": "Perque(TM) Perkies Cherry Raspberry each 270 tablets (Clinical Drug)" + }, + { + "input": "Definition: something described as the destruction of bone marrow using radiation or drugs.", + "output": "Bone Marrow Ablation (Myelosuppressive Therapy)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as PR domain zinc finger protein 16 (1276 aa, ~140 kDa) is encoded by the human PRDM16 gene. This protein plays a role in both transcriptional regulation and fat cell differentiation.", + "output": "PRDM16 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: Gram-Negative Aerobic Rods and Cocci described as a family of gram-negative aerobic bacteria in the order BURKHOLDERIALES, encompassing the acidovorans rRNA complex. Some species are pathogenic to PLANTS.", + "output": "Family Comamonadaceae (Burkholderiales)" + }, + { + "input": "Definition: Infection as complication of medical care described as an infection that arises secondary to catheter use.", + "output": "Catheter Related Infection (Device related infection)" + }, + { + "input": "Definition: Disease or Syndrome described as a benign or malignant solid pathologic process involving a lymph node.", + "output": "NODAL MASS (Mass of body structure)" + }, + { + "input": "Definition: Manufactured Object described as cabinets designed for organized storage of keys. These cabinets typically consist of wall-mounted metallic, wooden, or plastic units with hooks or other appropriate means to hold one or more keys and/or with identifying numbering labels. Most key cabinets include several panels (or trays) that support key hooks. They may include sliding trays, foldout locking doors, and/or other locking mechanisms. Key storage cabinets are available in many different sizes to store from a few hundreds or even thousands of keys.", + "output": "Cabinets, Storage, Key (Manufactured Object)" + }, + { + "input": "Definition: something described as a substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is called recombinant human TPO and rHu TPO. TPO is being studied as a way to increase the number of platelets in cancer patients receiving chemotherapy.", + "output": "Myeloproliferative Leukemia Virus Oncogene Ligand (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine.", + "output": "pantothenate hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: something described as primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.", + "output": "Supratentorial Neoplasms (Brain Neoplasms)" + }, + { + "input": "Definition: DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - During deployment: I had a major conflict with a family member or other loved one.", + "output": "DRRI1-M: Had Major Conflict With Family (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as small nuclear ribonucleoprotein F (86 aa, ~10 kDa) is encoded by the human SNRPF gene. This protein is involved in pre-mRNA splicing.", + "output": "Sma (Biologically Active Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as brand name of an antibiotic", + "output": "Flagyl (Pharmacologic Substance)" + }, + { + "input": "Definition: Reproductive organ and breast histopathology procedures described as removal of tissue from the vagina for microscopic examination.", + "output": "vagina biopsy (Diagnostic procedures on vagina and cul-de-sac)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation.", + "output": "negative regulation of immature T cell proliferation (Cell Function)" + }, + { + "input": "Definition: Medical Device described as microtomes contained in a temperature-controlled stainless steel cabinet called a cryostat. The cryostat microtome allows microtomists to section frozen tissue specimens for histopathologic analysis. The microtome, tissue specimen, and knife are housed in a thermostatically controlled chamber insulated with polyurethane foam. The operator passes the specimen through an opening in the chamber and places it on a refrigerated holder near the microtome. The microtome freezes the specimen with an aerosol-propelled freezing agent before placing it in the chamber or inserts it into an optional quick-freezing specimen holder or polyglycol matrix.", + "output": "Microtomes, Cryostat (Microtome - medical device)" + }, + { + "input": "Definition: Finding described as perihilar bile duct cancer with tumor invading adjacent hepatic parenchyma.", + "output": "Perihilar Cholangiocarcinoma pT2b TNM Finding v8 (Perihilar Bile Duct Cancer pT2 TNM Finding v8)" + }, + { + "input": "Definition: something described as a standard by which something can be measured or judged.", + "output": "Benchmark (Conceptual Entity)" + }, + { + "input": "Definition: Abnormality of the scapula described as bony fusion between the humerus and scapula, leading to an impairment in mobility of the affected shoulder joint.", + "output": "Scapulohumeral synostosis (Abnormality of the humerus)" + }, + { + "input": "Definition: PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - During the last week, has it been easy or hard for your child to: Walk one block?", + "output": "PODCI Adolescent Parent-Reported Version - Walk One Block (PODCI Adolescent Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Mytilinae described as a genus of marine mussels in the family MYTILIDAE, class BIVALVIA. The species MYTILUS EDULIS is the highly edible common mussel.", + "output": "Mytilus (Mytilidae)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a radioimmunoconjugate of a murine monoclonal antibody, MoAb Lym-1, labeled with yttrium 90 (Y-90). MoAb Lym-1 recognizes an epitope of the histocompatibility antigen HLA-DR, which is over-expressed on most B-cell lymphomas. Y-90 MoAb Lym-1 delivers Y-90 radionuclide directly to tumor cells that express HLA-DR antigen, thereby this agent may be used in radioimmunotherapy of cancers.", + "output": "monoclonal antibody Lym-1, yttrium Y 90 (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis.", + "output": "adenosine salvage (adenosine biosynthetic process)" + }, + { + "input": "Definition: Health care facility described as a place that gives care to people who have physical or mental disabilities and need help with activities of daily living (such as taking a bath, getting dressed, and going to the bathroom) but do not need to be in the hospital.", + "output": "Long term care facility (Residential Facilities)" + }, + { + "input": "Definition: Finding described as supraglottic cancer with distant metastasis.", + "output": "Supraglottic Cancer cM1 TNM Finding v7 (Supraglottic Cancer Clinical Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: Ataxia, Spinocerebellar described as an autosomal recessive spinocerebellar ataxia caused by an expanded CAG repeat in the CACNA1A gene, encoding voltage-dependent P/Q-type calcium channel subunit alpha-1A. It is an almost pure cerebellar syndrome, with onset typically between the ages of 20 to 60.", + "output": "Ataxia 6, Spinocerebellar (Hereditary cerebellar degeneration)" + }, + { + "input": "Definition: Intellectual Product described as the Overactive Bladder Questionnaire (OAB-q) Made you worry about odor or hygiene?", + "output": "OABQ01-Worry About Odor or Hygiene (Intellectual Product)" + }, + { + "input": "Definition: something described as a proposed method to describe the overall strategy for timelines, management, and conduct of a clinical trial.", + "output": "Project Management Plan (Intellectual Product)" + }, + { + "input": "Definition: Mammal described as a compact, medium-sized dog with a medium-length, dark red and white coat that is straight or slightly wavy with feathering on the chest, undersides, legs, and tail. The longish pendant ears are fringed with hair, somewhat like a setter's. The average height range is 16-19 inches and the average weight range is 35-45 pounds.", + "output": "Springer Spaniel (Springer spaniel)" + }, + { + "input": "Definition: Molecular Function described as enables the directed movement of lipids into, out of or within a cell, or between cells.", + "output": "lipid transporter activity (Molecular Function)" + }, + { + "input": "Definition: Racial group described as persons living in the United States having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent.", + "output": "Asian American (US minority racial or ethnic group)" + }, + { + "input": "Definition: filtration diaphragm described as a specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates.", + "output": "nephrocyte diaphragm (filtration diaphragm)" + }, + { + "input": "Definition: Neuronal Calcium-Sensor Proteins described as neuronal calcium sensor proteins that regulate the activation of membrane-bound GUANYLATE CYCLASE. They are primarily expressed in the RETINA where they play an important role in PHOTOTRANSDUCTION.", + "output": "Guanylate Cyclase Activating Proteins (Biologically Active Substance)" + }, + { + "input": "Definition: Interferometry described as a method of three-dimensional morphometry in which contour maps are produced from the overlapping interference fringes created when an object is illuminated by beams of coherent light issuing from two different point sources.", + "output": "MOIRE TOPOGR (Laboratory Procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and fused, at its C-terminus, to full-length human serum albumin (HSA), with potential antineoplastic and anti-angiogenic activities. sEphB4-HSA functions as a decoy receptor for the membrane-bound ligand Ephrin-B2 (Efnb2) and interferes with the binding of Efnb2 to its native receptors, including EphB4 and EphA3. This may result in a reduction of angiogenesis and a reduction in cell growth of Efnb2 and/or EphB4 over-expressing tumor cells. In addition, this agent also prevents the angiogenic effects of numerous growth factors due to interactions between Efnb2 and EphB4. Efnb2 and EphB4 are overexpressed in a variety of tumor cell types; the bi-directional signaling of Efnb2-EphB4 plays an important role in angiogenesis and tumor cell migration, invasion, and proliferation. Albumin reduces this agent's degradation, improves circulation time and may thus improve efficacy.", + "output": "SEphB4-HSA (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as the branch of pharmacology that deals with the biochemical and physiological effects of a drug and the mechanism of drug action in relation to its desired therapeutic target.", + "output": "PRIMARY PHARMACODYNAMICS (Module 4: Pharmacology)" + }, + { + "input": "Definition: MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of breast carcinoma and diarrhea-predominant irritable bowel syndrome.", + "output": "MIRN510 (Gene or Genome)" + }, + { + "input": "Definition: something described as presence of inactivating antibodies to prothrombin (factor II) in the blood.", + "output": "Factor II Inhibitor Present (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a type of contrast-enhanced MRI that allows observation of functional properties in addition to structural properties.", + "output": "DCE MRI (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as a metric unit of volumetric radioactivity concentration defined as a concentration of a radionuclide with an activity equal to one becquerel per unit volume equal to one milliliter or one kilobecquerel per liter.", + "output": "kBq/l (Radioactivity Concentration Unit)" + }, + { + "input": "Definition: Laboratory Procedure described as preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.", + "output": "cold storage (Laboratory Procedures)" + }, + { + "input": "Definition: stage/cell type, thyroid cancer described as the reemergence of a thyroid gland carcinoma after a period of remission.", + "output": "Relapsed Thyroid Cancer (Recurrent Head and Neck Carcinoma)" + }, + { + "input": "Definition: something described as a chromosome band present on Xq", + "output": "Xq13 (Cell Component)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of tubulin deacetylase activity.", + "output": "regulation of tubulin deacetylase activity (regulation of deacetylase activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX.", + "output": "ferro-protoporphyrin chelatase activity (Molecular Function)" + }, + { + "input": "Definition: C-SSRS Lifetime/Recent Version Questionnaire Question described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - How many times have you had these thoughts? (Lifetime).", + "output": "C-SSRS Lifetime/Recent Version - Frequency of Most Severe Ideation (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: Property or Attribute described as an adjustment in a value based on scientific observations within the data.", + "output": "weighting (Property or Attribute)" + }, + { + "input": "Definition: Limb injury described as general or unspecified injuries to the hand.", + "output": "Injury to hand NOS (Disorder of hand)" + }, + { + "input": "Definition: Peripheral neurostimulator described as electrical stimulators used to apply precisely timed and repeatable stimuli to the peripheral nerves. These stimulators are usually multiple-channel external stimulators, using external surface electrodes or invasive (i.e., needle) electrodes. Somatosensory electrical stimulators are used for evoked-potential procedures and also for other research procedures (e.g., functional mapping in epilepsy). Some of these stimulators are used as components of more complex devices, such as somatosensory evoked-potential recorders.", + "output": "STIMULATOR, ELECTRICAL, EVOKED RESPONSE (Medical Device)" + }, + { + "input": "Definition: Orthognathic Surgical Procedures described as the physical restoration of oromandibular defects.", + "output": "Mandibular Reconstructions (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Cell Component described as a short structure attached to an icosahedral virion capsid, and used for attachment to the host cell.", + "output": "icosahedral viral capsid, spike (virion part)" + }, + { + "input": "Definition: ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) In the past 4 weeks, did subject make him or herself a meal or snack at home?", + "output": "ADCS-ADL MCI - Make a Meal or Snack (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: protein-tetrapyrrole linkage described as the covalent linkage of heme and a protein.", + "output": "protein-heme linkage (Molecular Function)" + }, + { + "input": "Definition: Operation on ovary described as surgery to remove one ovary.", + "output": "ovariectomy - unilateral (Unilateral procedure)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr.", + "output": "3,3'-dibromobisphenol A reductive dehalogenase activity (oxidoreductase activity)" + }, + { + "input": "Definition: Racks, Storage described as racks designed for holding and storing books and/or magazines. These racks typically consist of a metal, wooden, or plastic framework with several small shelves with brackets or pockets in which books and magazines are held; some book/magazine racks have adjustable shelves and supports to make them sturdier.", + "output": "Book/Magazine Storage Racks (Manufactured Object)" + }, + { + "input": "Definition: Pharmacologic Substance described as chemical substances that interrupt pregnancy after implantation.", + "output": "Medicinal product acting as abortifacient agent (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as either of two veins (left or right) that drain the second, third, and fourth intercostal spaces. The right superior intercostal vein drains into the right azygos vein while the left superior intercostal vein drains into the left innominate vein.", + "output": "Superior Intercostal Vein (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Eligibility for a Procedure described as the status of a tumor based on its characteristics, such as morphology, location, size, presence or absence of carcinoma in situ, vascular invasion, metastasis, and other empirical features with or without biological and molecular basis, that is eligible for definitive local therapy (e.g. surgery, radiation or ablation that is chosen as the primary treatment modality).", + "output": "Status of Tumor (Eligibility for a Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as the reemergence of a glioma after a period of remission.", + "output": "Recurrent Glioma (Neoplastic Process)" + }, + { + "input": "Definition: something described as nonabsorbable polyamide surgical suture is a nonabsorbable, sterile, flexible thread prepared from long-chain aliphatic polymers Nylon 6 and Nylon 6,6 and is indicated for use in soft tissue approximation. The polyamide surgical suture meets United States Pharmacopeia (U.S.P.) requirements as described in the U.S.P. monograph for nonabsorbable surgical sutures; it may be monofilament or multifilament in form; it may be provided uncoated or coated; and it may be undyed or dyed with an appropriate FDA listed color additive. Also, the suture may be provided with or without a standard needle attached.", + "output": "Polyamide Sutures (Medical Device)" + }, + { + "input": "Definition: Finding described as a designation that has some relationship to motherhood.", + "output": "Maternal (PRENATAL MANIFESTATIONS)" + }, + { + "input": "Definition: something described as produced inside an organism or cell. The opposite is external (exogenous) production.", + "output": "Endogenous (Intrinsic origin)" + }, + { + "input": "Definition: DAD Questionnaire Question described as disability Assessment for Dementia (DAD) Use the toilet without 'accidents'?", + "output": "DAD - Use the Toilet Without Accidents (DAD Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as the trough concentration divided by dose.", + "output": "CTROUGHD (Trough Concentration)" + }, + { + "input": "Definition: Enzyme described as a recombinant form of reptilase identical to or similar to the blood-coagulation factor X activator from the tropical snake Bothrops atrox. Orthologous to human thrombin, batroxobin activates soluble fibrinogen into fibrin and facilitates blood coagulation, thereby can be used in substitution of thrombin in quantitative thrombin time test. Furthermore, as a serine protease, batroxobin has the potential applications in cardiovascular treatments, such as dissolving thrombus, preventing thrombus formation and improving microcirculation.", + "output": "batroxobin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle.", + "output": "negative regulation of glutamate metabolism via glutamine and ammonia (negative regulation of glutamate metabolic process)" + }, + { + "input": "Definition: Body Location or Region described as a cytoarchitecturally defined portion of the frontal lobe of the guenon. Brodmann-1909 regarded it on the whole as topographically and cytoarchitecturally homologous to the area 9 of Brodmann-1909 (human) and area 10 of Brodmann (human).\\r\\nDistinctive features ( Brodmann-1905 ): unlike area 6 of Brodmann (guenon), area 9 has a distinct internal granular layer (IV); unlike area 6 or area 8 of Brodmann (guenon) its internal pyramidal layer (V) is divisible into two sublayers, an outer layer 5a of densely distributed medium sized ganglion cells that partially merges with layer IV, and an inner, clearer, cell-poor layer 5b; the pyramidal cells of sublayer 3b of the external pyramidal layer (III) are smaller and sparser in distribution; the external granular layer (II) is narrow, with small numbers of sparsely distributed granule cells.", + "output": "9 (Body Location or Region)" + }, + { + "input": "Definition: Oils, Volatile described as citronella.", + "output": "Cymbopogon nardus (Oils, Volatile)" + }, + { + "input": "Definition: Serine/Threonine Kinase Inhibitor described as an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C111569\" active clinical trials using this agent.", + "output": "OTS167 (Organic Chemical)" + }, + { + "input": "Definition: something described as a group of nerve cells in the pontine tegmentum ( Crosby-1962 ).", + "output": "nucleus papilliformis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Quantitative Concept described as the total clearance of a substance from the blood minus the renal clearance divided by the surface area.", + "output": "Nonrenal CL Norm by SA (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Verbal fluency test (raw score).", + "output": "UHDR119 (Intellectual Product)" + }, + { + "input": "Definition: something described as abnormally reduced blood carbon dioxide (CO2) level.", + "output": "Hypocarbia (carbon dioxide tension)" + }, + { + "input": "Definition: Finding described as a variation from processes or procedures defined in a protocol. Deviations usually do not preclude the overall evaluability of subject data for either efficacy or safety, and are often acknowledged and accepted in advance by the sponsor. NOTE: Good clinical practice recommends that deviations be summarized by site and by category as part of the report of study results so that the possible importance of the deviations to the findings of the study can be assessed. Compare to protocol violation. [See ICH E3]", + "output": "Deviation (Finding)" + }, + { + "input": "Definition: something described as a preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101773\" active clinical trials using this agent.", + "output": "Anti-mesothelin CAR PBL (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Atrophic condition of skin described as poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias.", + "output": "Poikiloderma (Skin, Human)" + }, + { + "input": "Definition: Lymphangiectasis, Intestinal described as an extremely rare association syndrome, described in only two brothers to date (one of which died at 2 months of age), characterised by aplasia cutis congenita of the vertex and generalised oedema (as well as hypoproteinaemia and lymphopenia) due to intestinal lymphangiectasia. There have been no further descriptions in the literature since 1985.", + "output": "Aplasia cutis congenita with intestinal lymphangiectasia syndrome (Aplasia Cutis Congenita)" + }, + { + "input": "Definition: Clinical Study Status described as the status of a study such that a subject can be enrolled into that study. NOTE: Registry terminology in common use is \"open to recruitment\"; however, recruitment can begin upon IRB approval of the site; whereas enrollment requires availability of study supplies, subject informed consent, etc., to allow participation of eligible subjects.", + "output": "Open To Enrollment (Clinical Study Status)" + }, + { + "input": "Definition: Cephalosporins described as the dihydrochloride salt form of ceftazidime, a third-generation, beta-lactam, cephalosporin antibiotic with a wide range of activity against Gram-negative bacteria.", + "output": "1-(((6R,7R)-7-(((2Z)-(2-Amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)pyridinium Chloride Monohydrochloride (Organic Chemical)" + }, + { + "input": "Definition: something described as prospective, randomized, controlled trials and meta-analyses of prospective, randomized, controlled trials.", + "output": "Level of evidence I (Level of Evidence)" + }, + { + "input": "Definition: Organic Chemical described as an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems.", + "output": "TYRAMINE (Organic Chemical)" + }, + { + "input": "Definition: Muscle Weakness described as reduced strength and weakness of the muscles of the arms and legs.", + "output": "Loss of power in limb (Motor disturbances)" + }, + { + "input": "Definition: positive regulation of proteolysis described as any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.", + "output": "positive regulation of peptidase activity (regulation of peptidase activity)" + }, + { + "input": "Definition: Disease or Syndrome described as insomnia as a result of an extrinsic cause.", + "output": "sleep disorder; insomnia type, nonorganic origin (Disease or Syndrome)" + }, + { + "input": "Definition: gastrointestinal described as accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis.", + "output": "Crypt abscesses (Pathologic Function)" + }, + { + "input": "Definition: Quantitative Concept described as a dosing measurement based on the vial unit.", + "output": "VI (Potency Unit)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the EWSR1/ETV1 fusion gene. This protein is comprised of the transactivation domain of the RNA-binding protein EWS followed by ETS DNA binding domain of the ETS translocation variant 1 protein.", + "output": "EWS/ETV1 Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a concentration unit measured as a number of picogram equivalents of solute per milliliter of solution.", + "output": "pgEq/mL (Intellectual Product)" + }, + { + "input": "Definition: something described as a subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and rarely other tissues. Bone marrow typically shows small hypo-lobated megakaryocytes and multilineage dysplasia. Patients typically present with leukocytosis, anemia, and variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.", + "output": "Acute Myeloid Leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); GATA2, MECOM (Acute myeloid leukemia with recurrent genetic abnormality)" + }, + { + "input": "Definition: diterpenoid metabolic process described as the chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate.", + "output": "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism (Molecular Function)" + }, + { + "input": "Definition: Visceral Arterial Ischemia, CTCAE described as life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated", + "output": "Grade 4 Visceral arterial ischemia (Finding)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Taxane Version 4 - Physical Well-Being: I am bothered by side effects of treatment.", + "output": "FACT-Taxane Version 4 - Bothered by Treatment Side Effect (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(8;16)(p11;p13) which fuses the 5' portion of the KAT6A gene to most of the coding region of the CREBBP gene. This rearrangement is associated with acute myeloid leukemia.", + "output": "KAT6A/CREBBP Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - I am interested in sex.", + "output": "FAC06136 (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: active ion transmembrane transporter activity described as enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.", + "output": "antimonite secondary active transmembrane transporter activity (active ion transmembrane transporter activity)" + }, + { + "input": "Definition: something described as fine powderlike material consisting of pollen grains that is produced by the anthers of seed plants, such as flowers, grasses and trees that may cause allergic reactions in some individuals.", + "output": "Grains, Pollen (Plant Structures)" + }, + { + "input": "Definition: Central Nervous System described as the original answer string 'Mental retardation' was replaced per Rosa's Law", + "output": "intellectual disabilities (Neurobehavioral Manifestations)" + }, + { + "input": "Definition: Molecular Function described as the series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor.", + "output": "tachykinin receptor signaling pathway (GPCR Signaling Pathway)" + }, + { + "input": "Definition: Locally Advanced Sarcoma described as a leiomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.", + "output": "Locally Advanced Leiomyosarcoma (Locally Advanced Sarcoma)" + }, + { + "input": "Definition: Blood described as any of the various types of human blood whose antigen characteristics determine compatibility in transfusion. While the ABO and Rhesus sytems are the most well known, there are in total about 300 different blood type antigens distributed across 34 different blood type systems.", + "output": "blood type (Blood)" + }, + { + "input": "Definition: Iron and iron compound described as a metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.", + "output": "Ferrum (I [Preparations])" + }, + { + "input": "Definition: Phosphotransferases described as ceramide kinase (537 aa, ~60 kDa) is encoded by the human CERK gene. This protein plays a role in the phosphorylation of ceramides.", + "output": "Acylsphingosine Kinase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as a subset of terminology related to gestational diabetes mellitus, developed by the Global Alignment of Immunization safety Assessment in pregnancy consortium to aid in monitoring and improving fetal and maternal outcomes.", + "output": "GAIA Gestational Diabetes Mellitus Level of Diagnostic Certainty Terminology (GAIA Terminology)" + }, + { + "input": "Definition: Carbohydrates described as methylpentose structurally derived from galactose; the L isomer occurs naturally in various oligosaccharides and polysaccharides and fucosides and in the carbohydrate portion of some mucopolysaccharides and glycoproteins, including the A, B, and O blood group antigens.", + "output": "FUCOSE (Carbohydrates)" + }, + { + "input": "Definition: Anatomical point of skull described as anatomical point of skull located on the most medial part of mandibular condyle.", + "output": "cdm (Anatomical point of skull)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI), plus panitumumab that may be used in the treatment of certain types of colon and rectal cancers.", + "output": "FOLFOXIRI Plus Panitumumab (Regimen Used to Treat Colorectal Carcinoma)" + }, + { + "input": "Definition: Cell described as an abnormal type of white blood cell that is found in chronic myelomonocytic leukemia. These cells are similar to both monocytes and myelocytes (immature cells that develop into different types of immune system cells).", + "output": "Myelomonocyte (Abnormal Monocyte)" + }, + { + "input": "Definition: Squamous cell carcinoma described as a squamous cell carcinoma characterized by the formation of gland-like structures.", + "output": "Adenoid squamous cell ca (Primary malignant neoplasm)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the 25-Hydroxyvitamin D3 in a biological specimen.", + "output": "25-Hydroxyvitamin D3 (Laboratory Procedure)" + }, + { + "input": "Definition: something described as proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.", + "output": "RAR (Receptors, Cytoplasmic and Nuclear)" + }, + { + "input": "Definition: Temporal Concept described as the point in time that acts as a fixed reference point to meal data.", + "output": "Meal Data Time Point Reference (Temporal Concept)" + }, + { + "input": "Definition: Gastrointestinal Hormones described as neuropeptide hormone whose receptors are present on the cells of the anterior pituitary; stimulates the release of growth hormone affecting appetite and energy balance; its synthesis occurs in the epithelial cells lining the stomach.", + "output": "Gherlin (peptide hormone)" + }, + { + "input": "Definition: something described as human MAGEC1 wild-type allele is located in the vicinity of Xq26 and is approximately 6 kb in length. This allele, which encodes melanoma-associated antigen C1 protein, may be involved in embryonal development, tumor transformation, or tumor progression.", + "output": "Melanoma Antigen, Family C, 1 Gene (Gene or Genome)" + }, + { + "input": "Definition: Lesion by Morphology described as a lesion characterized by the absence of clinical and/or morphologic criteria that are suggestive of melanoma.", + "output": "Non-Melanomatous Lesion (Finding)" + }, + { + "input": "Definition: Cognition described as the act of \"taking account\" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.", + "output": "Awarenesses, Situation (Biological Processes)" + }, + { + "input": "Definition: Biomedical or Dental Material described as assembly of components intended for transdermal delivery driven by external forces (e.g., electrical current, chemical reaction).", + "output": "Transdermal System Dosage Form (Dosage Forms)" + }, + { + "input": "Definition: something described as chlamydia serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to chlamydia in serum. Additionally, some of these reagents consist of chlamydia antisera conjugated with a fluorescent dye used to identify chlamydia directly from clinical specimens or cultured isolates derived from clinical specimens. The identification aids in the diagnosis of disease caused by bacteria belonging to the genus Chlamydia and provides epidemiological information on these diseases. Chlamydia are the causative agents of psittacosis (a form of pneumonia), lymphogranuloma venereum (a venereal disease), and trachoma (a chronic disease of the eye and eyelid).", + "output": "ANTISERA, IMMUNOPEROXIDASE, CHLAMYDIA SPP. (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as a question about how much of the time something is occurring or has occurred.", + "output": "How Much of the Time (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Anxiety: Severity: How much has nervousness or worry affected your daily activities?", + "output": "UHDRS 1999 Version - Anxiety: Severity (Intellectual Product)" + }, + { + "input": "Definition: Myocardial dysfunction described as abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent. []", + "output": "myocardial dysfunction left cardiac ventricular systolic (Disorder of left cardiac ventricle)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is or was bothered by difficulty with self-care activities because of their neck or shoulder.", + "output": "Are you bothered by difficulty with self-care activities because of your neck or shoulder (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as the aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex.", + "output": "protein-DNA-RNA complex assembly (cellular protein-containing complex assembly)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) Arising: are you able to stand up from a straight chair?", + "output": "HAQ0103 (HAQ-DI Questionnaire Question)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 5, Word 3.", + "output": "AVL01-List A Recall 5 Word 3 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: Organism Function described as any process that modulates the frequency, rate, or extent of interleukin-5 production.", + "output": "regulation of IL-5 production (regulation of cytokine production)" + }, + { + "input": "Definition: Cell Component described as an iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.", + "output": "hemoglobin complex (protein-containing complex)" + }, + { + "input": "Definition: Orthoses, Lower Limb, Total, Gait described as gait total lower-limb functional orthoses propelled by the user's muscular power that are designed to make possible and/or improve a patient's gait. These devices provide support, supplement, and/or augment the limb functions through a linkage between both legs that permits simultaneous extension of one hip and flexion of the contralateral hip. These orthoses include a mechanism that provides the appropriate linkage between the legs for step-over-step gait (known as reciprocating gait orthoses, [RGO]). The mechanism usually includes a cable system to couple the leg extension and flexion; additional crutches are frequently needed to provide balance to the user.", + "output": "Self-Propelled Gait Orthoses (Orthoses, Lower Limb, Total, Gait)" + }, + { + "input": "Definition: something described as catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate.", + "output": "norleucine transaminase activity (aminotransferase activity)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 test name.", + "output": "FAC062TN (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.", + "output": "gonadotropin releasing hormone antagonist abarelix (Antineoplastic Agents)" + }, + { + "input": "Definition: something described as the developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud.", + "output": "tooth placode formation (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as any process involving pheromones that stops, prevents or reduces the rate of transcription.", + "output": "down regulation of transcription by pheromones (regulation of transcription by pheromones)" + }, + { + "input": "Definition: External Shock Wave Therapy Systems, Electromagnetic described as lithotripters that noninvasively disintegrate stones using focused external shock waves generated and delivered from electromagnetic generators. These lithotripters typically consist of electromagnetic generators where a magnetic field is produced by an electric current conducted through a coil attached to a thin metallic membrane; when the membrane is repelled by the magnetic field, a shock wave is generated. Extracorporeal electromagnetic lithotripters are intended for the treatment of urolithiasis (i.e., kidney calculi also known as kidney stones).", + "output": "Electromagnetic Extracorporeal Lithotripters (External Shock Wave Therapy Systems, Electromagnetic)" + }, + { + "input": "Definition: Hemangioendothelioma described as a cancer that causes patches of abnormal tissue to grow under the skin,", + "output": "Kaposi's sarcoma, unspecified site (Malignant neoplasm of skin)" + }, + { + "input": "Definition: Ventricular reservoir described as a plastic, dome-shaped device, with a catheter attached to the underside used to deliver chemotherapy to the central nervous system.", + "output": "Ommaya Reservoir (Drug Delivery Systems)" + }, + { + "input": "Definition: Records described as an electronic record for healthcare providers to create, import, store, and use clinical information for patient care, according to nationally recognized interoperability standards. NOTE: The EHR has the following distinguishing features: able to be obtained from multiple sources; shareable; interoperable; accessible to authorized parties.", + "output": "Medical Record, Electronic (Records)" + }, + { + "input": "Definition: Spastic Paraplegia, Hereditary described as a rare form of hereditary spastic paraplegia with characteristics of delayed walking, toe walking, unsteady and spastic gait, hyperreflexia of the lower limbs, and extensor plantar responses. Upper limbs spasticity and dystonia, subclinical axonal neuropathy, cognitive impairment and intellectual disability have also been associated. Caused by homozygous or compound heterozygous mutation in the CYP2U1 gene on chromosome 4q25.", + "output": "Autosomal recessive spastic paraplegia type 56 (Disease or Syndrome)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the lubrication of mucosal surfaces.", + "output": "mucin 2, oligomeric mucus/gel-forming (Gene or Genome)" + }, + { + "input": "Definition: something described as an oligosaccharide anthracycline antibiotic isolated from strains of the bacterium Streptomyces galilaeus with potential antineoplastic activity. These agents display potent antitumor properties due to their ability to intercalate into DNA and interfere with the function of both the topoisomerase I and II enzymes, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.", + "output": "aclacinomycins (Antibiotic)" + }, + { + "input": "Definition: Extrapulmonary legionella infection described as a self-limited, febrile illness without pneumonia that occurs in epidemics, and that is caused by Legionella species.", + "output": "Fever, Pontiac (Other bacterial diseases, not elsewhere classified)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal.", + "output": "Mossy Fibers, Hippocampal (dentate gyrus mossy fiber)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as bcl-2-like protein 1 (233 aa, ~26 kDa) is encoded by the human BCL2L1 gene. This protein is involved in the modulation of apoptosis.", + "output": "B-Cell Lymphoma-Extra Large (Biologically Active Substance)" + }, + { + "input": "Definition: Identifier described as a unique symbol that establishes identity of the healthcare provider. EXAMPLE(S): OTHER NAME(S): NOTE(S):", + "output": "Health Care Provider Identifier (Identifier)" + }, + { + "input": "Definition: Self-Injurious Behavior described as excessive pulling of one's own hair.", + "output": "hair pull (Behavioral/psychiatric manifestations)" + }, + { + "input": "Definition: something described as an embryonic structure that remains after the completion of the embryonic development of an organ or system.", + "output": "Embryonic remnant (Embryonic Structure)" + }, + { + "input": "Definition: Allergen class described as a salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1280\" active clinical trials using this agent.", + "output": "ZINC SULFATE (zinc)" + }, + { + "input": "Definition: Adrenergic alpha-Antagonists described as an alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents.", + "output": "Thymoxyalcylamine (Other peripheral vasodilators in ATC)" + }, + { + "input": "Definition: something described as abnormal difficulty in staying asleep. Affected individuals tend to wake up at night and have difficulty returning to sleep. []", + "output": "Maintenance insomnia (Sign or Symptom)" + }, + { + "input": "Definition: Surgical Clamps described as an obstetric-gynecologic general manual instrument is one of a group of devices used to perform simple obstetric and gynecologic manipulative functions. This generic type of device consists of the following: (1) An episiotomy scissors is a cutting instrument, with two opposed shearing blades, used for surgical incision of the vulvar orifice for obstetrical purposes. (2) A fiberoptic metal vaginal speculum is a metal instrument, with fiberoptic light, used to expose and illuminate the interior of the vagina. (3) A metal vaginal speculum is a metal instrument used to expose the interior of the vagina. (4) An umbilical scissors is a cutting instrument, with two opposed shearing blades, used to cut the umbilical cord. (5) A uterine clamp is an instrument used to hold the uterus by compression. (6) A uterine packer is an instrument used to introduce dressing into the uterus or vagina. (7) A vaginal applicator is an instrument used to insert medication into the vagina. (8) A vaginal retractor is an instrument used to maintain vaginal exposure by separating the edges of the vagina and holding back the tissue. (9) A gynecological fibroid hook is an instrument used to exert traction upon a fibroid. (10) A pelvimeter (external) is an instrument used to measure the external diameters of the pelvis.", + "output": "Clamps, Uterine (Medical Device)" + }, + { + "input": "Definition: Sister described as a female sibling who is legally adopted by one's biological parent or legal guardian.", + "output": "Adopted Sister (Sister)" + }, + { + "input": "Definition: Hereditary disorder of endocrine system described as a group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.", + "output": "Congenital adrenal hyperplasia (Congenital Adrenal Gland Disorder)" + }, + { + "input": "Definition: something described as the following anatomical structures define the neck lymph node boundary for sublevel IIA: Superior: skull base; inferior: horizontal plane defined by the inferior border of the hyoid bone; anterior (medial): stylohyoid muscle; posterior (lateral): vertical plane defined by the spinal accessory nerve.", + "output": "Neck Lymph Node Boundary Sublevel IIA (Neck Lymph Node Boundary Levels and Sublevels)" + }, + { + "input": "Definition: Appendiceal Carcinoma Pathologic Primary Tumor TNM Finding v8 described as appendiceal carcinoma with tumor invading the submucosa (through the muscularis mucosa but not into the muscularis propria).", + "output": "Appendiceal Carcinoma pT1 TNM Finding v8 (Appendiceal Carcinoma Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: something described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Over the past week, do you usually have trouble turning over in bed?", + "output": "MDS-UPDRS - Turning in Bed (Intellectual Product)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as an oval, membrane covered opening from the tympanic cavity of the middle ear to the vestibule of the inner ear.", + "output": "Fenestra Ovalis (Ear part)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.", + "output": "Cholecystikinin (Neurotransmitters & Neuroregulators)" + }, + { + "input": "Definition: something described as the inferior portion of the basal division of the left ventricular myocardium as determined using the AHA 17-Segment Model (Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002 Jan 29;105(4):539-42.).", + "output": "LEFT VENTRICULAR BASAL INFERIOR SEGMENT (Heart part)" + }, + { + "input": "Definition: regulation of antigen processing and presentation of peptide antigen described as any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.", + "output": "upregulation of antigen processing and presentation of peptide antigen (regulation of antigen processing and presentation of peptide antigen)" + }, + { + "input": "Definition: CPTAC Responses described as indicates that human immunodeficiency virus status of a sample is unknown.", + "output": "Human Immunodeficiency Virus Unknown (CPTAC Responses)" + }, + { + "input": "Definition: penicillins described as the sodium salt form of pirbenicillin, a broad-spectrum semisynthetic penicillin with antibacterial activity. Pirbenicillin binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.", + "output": "PIRBENICILLIN SODIUM (penicillins)" + }, + { + "input": "Definition: something described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.", + "output": "septin cytoskeleton organization (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - During the last 7 days, on how many days did you do moderate activities like carrying light loads, sweeping, washing windows, and raking in the garden or yard?: days per week.", + "output": "IPA03-Days Moderate in the Garden/Yard (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic motor neuron disease with characteristics of slowly progressive predominantly proximal muscular weakness and atrophy which typically manifests with muscle cramps, fasciculations, decreased/absent deep tendon reflexes, hand tremor and elevated serum creatine kinase at onset and later associates gait disturbances and impaired vibration sensation. There is evidence the disease is caused by heterozygous mutation in the CHCHD10 gene on chromosome 22q11.", + "output": "Lower motor neuron syndrome with late-adult onset (Spinal Muscular Atrophy)" + }, + { + "input": "Definition: Finding described as a subjective score of 90% on a scale that ranges from 0%: None to 100%: All of my food.", + "output": "Percentage Food Eaten Score 90 (Finding)" + }, + { + "input": "Definition: something described as a fiber bundle located in the transition zone between the lateral white column and the anterior white column on the anterior surface of the spinal cord. It was originally said to descend from the inferior olivary complex to cervical segments of the spinal cord. Some authors report, however, that it contains fibers of the spino-olivary tracts, not olivospinal fibers ( Carpenter-1983, Brodal-1950 ). It is composed of the olivospinal tract of the medulla and the olivospinal tract of the spinal cord.", + "output": "olivospinal fibers (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: purine ribonucleoside triphosphate binding described as interacting selectively and non-covalently with XTP.", + "output": "XTP binding (purine ribonucleoside triphosphate binding)" + }, + { + "input": "Definition: Urine protein test described as the determination of the ratio of urea-nitrogen to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "Urea Nitrogen to Creatinine Ratio Measurement (Urine protein test)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.", + "output": "RNA polymerase core enzyme binding (Molecular Function)" + }, + { + "input": "Definition: Pancreatic Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 described as pancreatic neuroendocrine tumor in which the primary tumor cannot be assessed.", + "output": "Pancreatic Neuroendocrine Tumor pTX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Anatomical Abnormality described as a bony projection (spur, osteophyte) originating from the femur, often in the medial femoral neck. []", + "output": "Femoral spur (Abnormality of femur morphology)" + }, + { + "input": "Definition: something described as a molecular finding indicating the absence of multiple copies of the MYCN gene in a tissue sample.", + "output": "Absence of MYCN Gene Amplification (Laboratory or Test Result)" + }, + { + "input": "Definition: Human rhinovirus described as any viral organism that can be assigned to the species Rhinovirus A.", + "output": "HRV-A (Human rhinovirus)" + }, + { + "input": "Definition: monocarboxylic acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.", + "output": "gamma-aminobutyric acid biosynthesis (Amino Acid Biosynthesis)" + }, + { + "input": "Definition: something described as a capillary hemangioma that may regress spontaneously. It occurs in infants and children.", + "output": "Infantile Hemangioma (benign childhood vascular tumor)" + }, + { + "input": "Definition: Colloid, body substance described as a colloid that has a continuous liquid phase in which a solid is suspended in a liquid.", + "output": "Colloidal Solution (Colloid, body substance)" + }, + { + "input": "Definition: Antimonic acid-containing product described as ANTIMONY salt of meglumine that is used in the treatment of LEISHMANIASIS.", + "output": "meglumine antimoniate (Antileishmanial)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Low-intensity leisure activity (gardening, etc.).", + "output": "FAC10053 (Intellectual Product)" + }, + { + "input": "Definition: something described as a rare chromosomal anomaly associated with a wide range of phenotypic features depending on the size of the deletion. It may present with intrauterine growth retardation, failure to thrive, global developmental delay, dysmorphic features (such as broad forehead, midface retrusion, broad nasal bridge, micrognathia, smooth philtrum, low-set, dysplastic ears), congenital anomalies (such as atrial septal defect, gastrointestinal anomalies, renal and urogenital malformations, agenesis of the corpus callosum) and other clinical features (such as hearing loss, visual impairment and immune dysregulation).", + "output": "Distal monosomy 19p13.3 (Deletion of short arm of chromosome 19)" + }, + { + "input": "Definition: Estradiol and estradiol derivative described as semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution; has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives.", + "output": "Ethinyl estradiol (Estranes)" + }, + { + "input": "Definition: Cell Component described as components of the cytoplasm excluding the CYTOSOL.", + "output": "Structures, Cytoplasmic (Cell Component)" + }, + { + "input": "Definition: something described as a dose calculation unit expressed in gram(s) per cage.", + "output": "g/{cage} (Unit of Dose Calculation)" + }, + { + "input": "Definition: something described as physical location of DOCK1_Gene", + "output": "10: 128658955-129140571 (Chromosome 10 Physical Location)" + }, + { + "input": "Definition: Intellectual Product described as infusion pump software designed to reduce programming errors during the administration of medications using infusion pumps (the pumps are typically known as 'smart' pumps) by using drug dose libraries and standard limits for a facility's medications, electrolytes, and other infusates. Dose error reduction system (also known as DERS) software is intended to improve the safety of infusion procedures by warning users of incorrect medication orders, calculation errors, and misses in programming; the software only works with one or a few models of infusion pumps, usually from the same manufacturer. Some software packages include automated programming and data logging and perform a variety of algorithms to facilitate the analysis of the information related to the drug to be administered; the software typically includes interfaces to pharmacy, electronic documentation, and/or other hospital information systems.", + "output": "Software, Infusion Pump, Dose Error Reduction (Computer software)" + }, + { + "input": "Definition: something described as the accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.", + "output": "nitric oxide storage (Biologic Function)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the total (free and bound) thyroxine in a biological specimen.", + "output": "Total thyroxine level (Laboratory Procedure)" + }, + { + "input": "Definition: Congenital malformation syndrome described as describes the combination of two or more of the following anomalies: neural tube defects (e.g. anencephaly, encephalocele, spina bifida cystica), cleft lip and palate, omphalocele and congenital diaphragmatic hernia . These anomalies are associated at a higher frequency than would be expected with random combination rates.", + "output": "Schisis association syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of topical alitretinoin that may be used in the treatment of AIDS-related Kaposi sarcoma.", + "output": "Topical Panretin Regimen (Regimen Used to Treat Kaposi Sarcoma)" + }, + { + "input": "Definition: Forecast of outcome described as the likely outcome or course of a disease; the chance of recovery or recurrence.", + "output": "outcome prediction (Health Care Activity)" + }, + { + "input": "Definition: Tricuspid valve disorder described as the more common indirect type of communication where the flow of blood is from the left ventricle through a ventricular septal defect into the right ventricle and then through a defect in the tricuspid valve into the right atrium.", + "output": "Ventricular septal defect between left ventricle and right atrium (Tricuspid valve lesion)" + }, + { + "input": "Definition: Physiologic Function described as any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.", + "output": "positive regulation of natural killer cell mediated immunity (positive regulation of innate immune response)" + }, + { + "input": "Definition: something described as the branch of pharmacokinetics that studies the process by which a drug is distributed by the body.", + "output": "DISTRIBUTION (Study Reports: Pharmacokinetics)" + }, + { + "input": "Definition: regulation of type II hypersensitivity described as any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.", + "output": "regulation of type IIa hypersensitivity (Pathologic Function)" + }, + { + "input": "Definition: something described as a term that refers to the staging of primary peritoneal cancer according to the American Joint Committee on Cancer, 7th edition.", + "output": "Primary Peritoneal Cancer by AJCC v7 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as records of all subjects considered for participation in a clinical trial.", + "output": "Subject Identification Log (Intellectual Product)" + }, + { + "input": "Definition: positive regulation of execution phase of apoptosis described as any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.", + "output": "up regulation of apoptotic DNA fragmentation (Molecular Function)" + }, + { + "input": "Definition: Other Embryologic Structure described as the transparent extraembryonic sac that holds the developing fetus and surrounding amniotic fluid.", + "output": "amniotic sac (Blastocyst sac)" + }, + { + "input": "Definition: something described as organometallic compounds which contain tin and three alkyl groups.", + "output": "Compounds, Trialkyltin (Organic Chemical)" + }, + { + "input": "Definition: something described as 7-carbon saturated monocarboxylic acids.", + "output": "Acids, Heptanoic (Organic Chemical)" + }, + { + "input": "Definition: something described as problem associated with an electrical activity that exceeded the specified threshold limit of the internal integrated circuitry.", + "output": "Electrical Overstress (Medical Device Electronic Property Issue)" + }, + { + "input": "Definition: DCAF7 gene described as human DCAF7 wild-type allele is located in the vicinity of 17q23.3 and is approximately 44 kb in length. This allele, which encodes DDB1- and CUL4-associated factor 7 protein, may be involved in regulation of transcription.", + "output": "DDB1 and CUL4 Associated Factor 7 wt Allele (DCAF7 gene)" + }, + { + "input": "Definition: positive regulation of cellular biosynthetic process described as any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process.", + "output": "up-regulation of fumagillin anabolism (Molecular Function)" + }, + { + "input": "Definition: Vitamin analyses described as a measurement of the thiamine in a biological specimen.", + "output": "Assay of vitamin b-1 (Chemical procedure)" + }, + { + "input": "Definition: something described as the alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "modulation by symbiont of jasmonic acid levels in host (modulation by symbiont of host hormone or growth regulator levels)" + }, + { + "input": "Definition: Temporal Qualifier described as continually recurring or continuing without interruption.", + "output": "Constant (Qualitative Concept)" + }, + { + "input": "Definition: Disease Grade Qualifier described as a score on the Modified Ryan Scheme for Tumor Regression that indicates a complete response, defined as having no viable cancer cells.", + "output": "Complete Response Score 0 (Disease Grade Qualifier)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as protein BTG2 (158 aa, ~17 kDa) is encoded by the human BTG2 gene. This protein plays a role in the regulation of both cell proliferation and transcription.", + "output": "Protein BTG2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Association fibers and tracts described as a broad vertically oriented fiber pathway that passes from the lateral geniculate nucleus, through the retrolenticular part of the internal capsule and posterior limb of the internal capsule to the primary visual cortex: primary visual cortex and monkey area 17 of Brodmann (guenon) ( Carpenter-1983 ). It is a continuous structure, but two parts are distinguished: a more dorsal superior optic radiation and a more ventral inferior optic radiation ( Crosby-1962 ).", + "output": "visual radiations (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Chemistry Techniques, Analytical described as a methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for MOLECULARLY IMPRINTED POLYMERS (MIPs) include separations, assays and biosensors, and catalysis.", + "output": "Imprinting Technique, Molecular (Chemistry Techniques, Synthetic)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A) gene, located at chromosome 17q23-q24, which encodes for a regulatory subunit of protein kinase A (PKA). PKA is activated by the second messenger cAMP and has a variety of important functions. This genetic mutation has been identified in patients with familial myxoma (Carney complex type 1, CNC1).", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PRKAR1A (Medical Device)" + }, + { + "input": "Definition: Professional Organization or Group described as an administrative unit established to oversee efforts that transcend organizational boundaries.", + "output": "Program Office (Group)" + }, + { + "input": "Definition: something described as catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+).", + "output": "aldehyde oxygenase (deformylating) activity (carbon-carbon lyase activity)" + }, + { + "input": "Definition: KCNQ1 gene described as human KCNQ1 wild-type allele is located in the vicinity of 11p15.5 and is approximately 404 kb in length. This allele, which encodes potassium voltage-gated channel subfamily KQT member 1 protein, plays a role in the regulation of both cardiac repolarization and potassium transport. Mutations in the gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.", + "output": "SQT2 (Gene or Genome)" + }, + { + "input": "Definition: Neoplastic Process described as wilms tumor that is found in areas near the kidney and cannot be completely removed with surgery. The tumor may have spread to nearby organs and blood vessels or throughout the abdomen and to nearby lymph nodes. Lymph nodes are tiny, bean-shaped organs that help fight infection. Stage III cancer has not spread outside the abdomen.", + "output": "Stage III Renal Wilms' Tumor (stage, Wilms tumor)" + }, + { + "input": "Definition: T4 free measurement described as an indirect measurement of the free thyroxine in a biological specimen.", + "output": "Thyroxine, Free, Indirect (Laboratory Procedure)" + }, + { + "input": "Definition: Bullet-shaped phalanges of the hand described as an abnormal morphology of one or more phalanges of the thumb, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.", + "output": "Bullet-shaped phalanges of the thumb (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as a disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Also known as posterior reversible encephalopathy syndrome (PRES).", + "output": "Reversible Posterior Leukoencephalopathy Syndrome (Nervous System Disorders, CTCAE)" + }, + { + "input": "Definition: Physiologic Function described as any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.", + "output": "down-regulation of immunoglobulin production (negative regulation of production of molecular mediator of immune response)" + }, + { + "input": "Definition: something described as pertaining to the lower portion of the surface on the same side of the joint when it bends.", + "output": "LOWER FLEXOR SURFACE (Anatomic Surface)" + }, + { + "input": "Definition: Anaplastic large cell lymphoma T- and null-cell types described as t-cell non-Hodgkin lymphoma resistant to treatment.", + "output": "Refractory T-Cell Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate.", + "output": "6-aminohexanoate transaminase activity (Molecular Function)" + }, + { + "input": "Definition: Hydrolase Gene described as genes (superfamily) that encode GTP hydrolyzing enzymes, which cycle between the GDP-bound inactive state and the GTP-bound active state acting as intracellular switches in various cellular pathways, such as signal transduction.", + "output": "GTPase Gene (Hydrolase Gene)" + }, + { + "input": "Definition: Clinical Trials described as the initial introduction of an investigational new drug into humans. Phase 1 studies are typically closely monitored and may be conducted in patients or normal volunteer subjects. NOTE: These studies are designed to determine the metabolism and pharmacologic actions of the drug in humans, the side effects associated with increasing doses, and, if possible, to gain early evidence on effectiveness. During Phase 1, sufficient information about the drug's pharmacokinetics and pharmacological effects should be obtained to permit the design of well-controlled, scientifically valid, Phase 2 studies. The total number of subjects and patients included in Phase I studies varies with the drug, but is generally in the range of 20 to 80. Phase 1 studies also include studies of drug metabolism, structure-activity relationships, and mechanism of action in humans, as well as studies in which investigational drugs are used as research tools to explore biological phenomena or disease processes. [After FDA CDER Handbook, ICH E8]", + "output": "Phase I Clinical Trial (Clinical Trials)" + }, + { + "input": "Definition: PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) If you answered \"no\" to Question 36 above, was your child's activity limited by: Fear the other kids won't like him/her?", + "output": "PODCI1-Outdoor Limited by: Fear (Intellectual Product)" + }, + { + "input": "Definition: Cardiomyopathy, Dilated described as a rare familial dilated cardiomyopathy with characteristics of left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase.", + "output": "Familial dilated cardiomyopathy with conduction defect due to lamin A/C mutation (Conduction disorder of the heart)" + }, + { + "input": "Definition: cellular response to DNA damage stimulus described as any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage.", + "output": "regulation of transcription from RNA polymerase II promoter in response to DNA damage (regulation of transcription from RNA polymerase II promoter in response to stress)" + }, + { + "input": "Definition: something described as any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.", + "output": "leukemia inhibitory factor signaling pathway (enzyme linked receptor protein signaling pathway)" + }, + { + "input": "Definition: Chondrogenic Neoplasm described as a neoplastic chondrogenic process affecting multiple sites. Grossly and microscopically it resembles an osteochondroma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53457\" active clinical trials using this agent.", + "output": "Osteochondromatosis (Chondrogenic Neoplasm)" + }, + { + "input": "Definition: ELAV Proteins described as a neural-specific RRM protein that binds to several 3'UTRs, including its own as well as that of PROTO-ONCOGENE PROTEINS C-FOS and ID DNA BINDING PROTEIN INHIBITOR. It binds through the recognition of a GAAA motif in the RNAs.", + "output": "HuB Antigen (ELAV Proteins)" + }, + { + "input": "Definition: something described as reagents intended to establish points of reference (i.e., calibrate) of a group of liquids, solids, or semisolids used as a medium capable of supporting the growth of microorganisms (e.g., bacteria); these calibrators may be specific either for manual or automated tests.", + "output": "IVD Test Reagent/Kits, Microbiology, Calibration, Culture Media (Medical Device)" + }, + { + "input": "Definition: Medical Device described as a cutting device usually consisting of a sharpened blade attached to a handle.", + "output": "knives (Cutlery)" + }, + { + "input": "Definition: algorithm described as information application based on a variety of coding methods to minimize the amount of data to be stored, retrieved, or transmitted. Data compression can be applied to various forms of data, such as images and signals. It is used to reduce costs and increase efficiency in the maintenance of large volumes of data.", + "output": "Compression (Information Storage and Retrieval)" + }, + { + "input": "Definition: Congenital megalogastria described as narrowing of the pyloric channel, the opening from the stomach to the duodenum, caused by enlargement and thickening of the circular muscular layer surrounding this opening.", + "output": "Congenital or infantile stenosis of pylorus (Pyloric Stenosis)" + }, + { + "input": "Definition: Temporal Qualifier described as at any time in the past, present, or future.", + "output": "At Any Time (Temporal Qualifier)" + }, + { + "input": "Definition: something described as the historical fact that a legal or consanguineous brother or sister has died.", + "output": "Sibling dead (Death of relative)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Rapid Test, Toxicology, Antidepressant described as immunoassay reagents intended to perform qualitative analyses on a body fluid sample (e.g., serum) to determine in a short period of time (typically several minutes), one or more of a group of tricyclic antidepressant drugs, including amitryptiline, desipramine, doxepin, imipramine, and nortriptyline. Reagents used for rapid determination of tricyclic antidepressant concentration in blood differentiate therapeutic levels (typically very low) from toxic levels due to overdose when these drugs are ingested either accidentally or intentionally. The active metabolites of these antidepressants contribute to both therapeutic and adverse effects of these compounds. Rapid tests for tricyclic antidepressant determination are mostly used in emergency situations.", + "output": "IVD Test Reagent/Kits, Immunoassay, Rapid Test, Toxicology, Antidepressant, Tricyclic (Medical Device)" + }, + { + "input": "Definition: Neoplasms, Intracranial described as a malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).", + "output": "metastatic brain cancer (Malignant neoplasm of brain)" + }, + { + "input": "Definition: Miscellaneous Occupation described as occupations involved in refining of raw materials, creation of finished goods, and distribution of materials or services.", + "output": "Processing, Manufacturing, or Utilities (Miscellaneous Occupation)" + }, + { + "input": "Definition: Cell Function described as the aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.", + "output": "interphase microtubule organising center formation (cellular component assembly)" + }, + { + "input": "Definition: Stage II Penile Cancer AJCC v8 described as stage IIA includes: (T1b, N0, M0); (T2, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IIA Penile Cancer AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Cerebrovascular accident described as dementia, due to significant cerebrovascular disease, with a stepwise deteriorating course and a 'patchy' distribution of neurologic deficits.", + "output": "multi-infarct dementia or psychosis (Psychological Disorders)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the regulation and modulation of inflammatory processes.", + "output": "INFLAMMATORY CYTOKINE I-309 (CC Cytokine Gene)" + }, + { + "input": "Definition: Esophagectomy described as excision of part (partial) or all (total) of the esophagus.", + "output": "Excision of oesophagus NOS (Esophagectomy)" + }, + { + "input": "Definition: Appendiceal Carcinoma Pathologic Primary Tumor TNM Finding v7 described as appendiceal carcinoma with tumor invading muscularis propria.", + "output": "Appendiceal Carcinoma pT2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Neuropathy described as an autosomal recessive condition characterised by progressive degeneration of the central and peripheral nervous system with enlargement of axons.", + "output": "Neuropathy, Giant Axonal (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Virus described as produces malignant lymphomata in marmosets and owl monkeys with lymphocytosis and reticular cell invasion of the viscera.", + "output": "Saimirus, Herpesvirus (Virus)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any pharmacologic intervention used to destroy or dissolve a clot in a blood vessel or graft.", + "output": "therapy thrombolytic (Cardiovascular therapy)" + }, + { + "input": "Definition: Pharmacologic Substance described as indian cockroach.", + "output": "blatta orientalis/indian coc (Organic Chemical)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of cell migration.", + "output": "regulation of cell migration (Cell Function)" + }, + { + "input": "Definition: something described as a classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm.", + "output": "Paraneoplastic Syndrome (Neoplastic Process)" + }, + { + "input": "Definition: Phobic anxiety disorder described as excessive fear of being alone, or being in public places or situations (e.g., in crowds or elevators) from which there is no easy escape or where help cannot be obtained in the event of an incapacitating reaction or panic.", + "output": "AGORAPHOBIA (Psychological Disorders)" + }, + { + "input": "Definition: Statutes and Laws described as an Act prohibiting a health plan from establishing lifetime limits or annual limits on the dollar value of benefits for any participant or beneficiary after January 1, 2014. It permits a restricted annual limit for plan years beginning prior to January 1, 2014. It provides that a health plan shall not be prevented from placing annual or lifetime per-beneficiary limits on covered benefits. The Act sets up a competitive health insurance market.", + "output": "Public Law 111-148 (Regulation or Law)" + }, + { + "input": "Definition: Transcription Regulatory Protein described as b-cell CLL/lymphoma 7 protein family member B (202 aa, ~22 kDa) is encoded by the human BCL7B gene. This protein plays a role in chromatin remodeling and apoptotic signaling.", + "output": "BCL7B (Transcription Regulatory Protein)" + }, + { + "input": "Definition: Cell Component described as membrane-like channels of cytoplasm connecting adjacent plant cells. Plasmodesmata connect through pores in the CELL WALL and associate with the CYTOSKELETON machinery. They are essential for intercellular transport and communication.", + "output": "plasmodesmata (Intercellular Junctions)" + }, + { + "input": "Definition: something described as baby Eating Behaviour Questionnaire Concurrent Version (BEBQ Concurrent Version) If allowed to, my baby would take too much milk.", + "output": "BEBQ01-Baby Would Take Too Much Milk (BEBQ Concurrent Version Questionnaire Question)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior.", + "output": "rectal diverticulum development (Organ or Tissue Function)" + }, + { + "input": "Definition: Medical Device described as an ultrasonic air embolism monitor is a device used to detect air bubbles in a patient's blood stream. It may use Doppler or other ultrasonic principles.", + "output": "MONITOR, AIR EMBOLISM, ULTRASONIC (Medical Device)" + }, + { + "input": "Definition: clearance of foreign intracellular nucleic acids described as a defense process that protects an organism from invading foreign DNA.", + "output": "clearance of foreign intracellular DNA (Cell Function)" + }, + { + "input": "Definition: Homeopathic remedies letter A described as ether, ethylic ether.", + "output": "Aether (Homeopathic remedies letter A)" + }, + { + "input": "Definition: Congenital Abnormality described as a subtype of micronodular adrenal hyperplasia, characterized by multiple pigmented nodules, which may occur in isolation or as part of the Carney complex.", + "output": "PPNAD (Micronodular adrenal hyperplasia)" + }, + { + "input": "Definition: Nursing Assessment Entity described as group of symptoms related to effects of immobility", + "output": "Disuse Syndrome (Musculoskeletal System Finding)" + }, + { + "input": "Definition: Organic Chemical described as cashew nut.", + "output": "cashews nuts (Homeopathic remedies letter A)" + }, + { + "input": "Definition: Amoeba genus described as any unicellular, eukaryotic organism that is not assigned to the species level but can be assigned to the Naegleria genus level.", + "output": "Genus: Naegleria (Phylum Amoebozoa)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoma that arises from the maxillary sinus. Representative examples include squamous cell carcinoma, adenocarcinoma, and adenoid cystic carcinoma.", + "output": "Maxillary Sinus Cancer (Malignant neoplasm of maxillary sinus)" + }, + { + "input": "Definition: something described as a cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.", + "output": "mitotic cohesin complex (Cell Component)" + }, + { + "input": "Definition: Medical Device described as plain (nonimpregnated) dressings made of synthetic (e.g., polymers) or semisynthetic materials. These dressings may be adhesive or nonadhesive, and made of one or more synthetic polymers, including polyethylene and polyurethane. Synthetic dressings are intended to maintain a moist environment, absorb wound exudates and/or prevent the dressings from contact with bacteria; they are used in the management of dry or exudative wounds.", + "output": "Dressings, Nonimpregnated, Synthetic (Medical Device)" + }, + { + "input": "Definition: something described as records pertaining to an investigational product (IP).", + "output": "Invstgtl Med Prod Subcat (Intellectual Product)" + }, + { + "input": "Definition: something described as this gene plays a role in antigen presentation.", + "output": "HLA-DRA Gene (Genes, MHC Class II)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a group of nerve cells in the epithalamus ( Crosby-1962 ).", + "output": "interstitial nucleus of the habenular commissure (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as positioning and accommodation of eyes that allows the image to be brought into place on the FOVEA CENTRALIS of each eye.", + "output": "visual fixation (Visual Fields)" + }, + { + "input": "Definition: Pelvic prolapse conditions described as downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.", + "output": "uterus; prolapse (Female internal genitalia structure)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as improve understanding of the biology of opportunistic pathogens, identify potential molecular targets for effective therapies, and discover and delineate the structure and function of potential agents for prevention and treatment of HIV-associated OIs and other infections that are modified by HIV infection.", + "output": "Prevention and Treatment of Opportunistic Infection (Prophylactic treatment)" + }, + { + "input": "Definition: Multiple congenital anomalies described as a syndrome of prenatal growth deficiency with postnatal immature bone development, developmental asymmetry, abnormal sexual development, small triangular face, cafe-au-lait spots, digital anomalies, hip or elbow dislocations, and other abnormalities.", + "output": "Silver's syndrome (Multiple malformation syndrome, small stature, without skeletal dysplasia)" + }, + { + "input": "Definition: FGFR2 Protein Variant described as a change in the amino acid residue at position 375 in the fibroblast growth factor receptor 2 protein where tyrosine has been replaced by cysteine.", + "output": "CD332 Antigen Tyr375Cys (FGFR2 Protein Variant)" + }, + { + "input": "Definition: Idea or Concept described as the moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.", + "output": "ethic research (Idea or Concept)" + }, + { + "input": "Definition: Fetal ultrasound soft marker described as congenital abnormality where one, instead of the usual two, UMBILICAL ARTERY connects the fetus to the placenta.", + "output": "2 vessel umbilical cord (Congenital umbilical defect)" + }, + { + "input": "Definition: Organism Function described as the chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.", + "output": "catabolism by host of symbiont cell wall pectin (catabolism by host of symbiont carbohydrate)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a monoclonal antibody that is being studied in the treatment of some lymphomas. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.", + "output": "MDX-060 monoclonal antibody (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as recurrent infections by Neisseria meningitidis (one of the most common causes of bacterial meningitis), which is also known as meningococcus.", + "output": "Increased susceptibility to Neisseria meningitidis infections (Finding)" + }, + { + "input": "Definition: Kidney Diseases described as decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.", + "output": "Chronic kidney disease mineral and bone disorder (Disease or Syndrome)" + }, + { + "input": "Definition: Organic Chemical described as a chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1515\" active clinical trials using this agent.", + "output": "MCNU (Organic Chemical)" + }, + { + "input": "Definition: Pharmacologic Substance described as a humanized anti-CD123/anti-CD3 bispecific monoclonal antibody, with potential immunostimulating and antineoplastic activities. Anti-CD123/CD3 bispecific antibody JNJ-63709178 possesses two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD123, a tumor-associated antigen (TAA) overexpressed on the surface of certain tumor cells. Upon administration of JNJ-63709178, this bispecific antibody simultaneously binds to both CD3-expressing T cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This may result in potent CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain, is overexpressed in a variety of cancers; its expression is low or absent in normal, healthy cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C128486\" active clinical trials using this agent.", + "output": "anti-CD123/CD3 bispecific antibody JNJ-63709178 (Bispecific Monoclonal Antibodies)" + }, + { + "input": "Definition: something described as the flesh of animals used as food.", + "output": "Meat (meat and dairy products)" + }, + { + "input": "Definition: regulation of embryonic development described as any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.", + "output": "regulation of primitive RBC differentiation (regulation of embryonic development)" + }, + { + "input": "Definition: Chromosome 1 Physical Location described as physical location of FCGR2B_Gene", + "output": "1: 158364622-158379489 (Spatial Concept)" + }, + { + "input": "Definition: Medical Device described as monitoring systems designed to evaluate the physiologic response of a person to physical stress, typically while the individual is performing exercise on a treadmill, bicycle ergometer, or other equipment. These systems are used mostly to diagnose coronary artery diseases, to differentiate between cardiac and pulmonary diseases, and to diagnose and/or monitor the course of pulmonary and vascular diseases.", + "output": "Monitoring Systems, Physiologic, Stress Exercise (Physiologic monitoring system)" + }, + { + "input": "Definition: Domestic mammal described as large solid-hoofed herbivorous mammal (Equus caballus, family Equidae, the horse family) domesticated since a prehistoric period and used as a beast of burden, a draft animal, or for riding.", + "output": "Stallion (Equus caballus)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 3q", + "output": "3q13.1-q13.2 (Cell Component)" + }, + { + "input": "Definition: Disability issues described as having teeth in neither the mandible nor the maxilla.", + "output": "Toothless Mouth (Tooth absent)" + }, + { + "input": "Definition: Organism Function described as any process that modulates the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation.", + "output": "regulation of NMS complex assembly (regulation of kinetochore assembly)" + }, + { + "input": "Definition: Unit of Number Concentration described as a unit of measurement equal to one hundred thousand entities per unit of area equal to one high powered field.", + "output": "10^5.[HPF] (Unit of Number Concentration)" + }, + { + "input": "Definition: transferase complex described as complex that possesses imidazoleglycerol-phosphate synthase activity.", + "output": "imidazoleglycerol-phosphate synthase complex (transferase complex)" + }, + { + "input": "Definition: something described as mini-Mental State Examination 2 Standard Version - What is the date?", + "output": "MMS2-What Is the Date (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human SSTR3 wild-type allele is located in the vicinity of 22q13.1 and is approximately 6 kb in length. This allele, which encodes somatostatin receptor type 3 protein, plays a role in the inhibition of adenylyl cyclase.", + "output": "Somatostatin Receptor 3 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Finding described as acceptance of treatment; cautious behaviour at times; willingness to comply with the dentist, at times with reservation, but patient follows the dentist's directions cooperatively.", + "output": "Frankl behavioral rating positive (Finding)" + }, + { + "input": "Definition: something described as a chromosome band present on 7p", + "output": "7p15-p13 (Chromosome band)" + }, + { + "input": "Definition: something described as the developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip.", + "output": "metanephric cap formation (Organ or Tissue Function)" + }, + { + "input": "Definition: Pharyngeal disorders described as an abnormal communication between the pharynx and another organ or anatomic site.", + "output": "pharyngeal fistula (Pharyngeal Diseases)" + }, + { + "input": "Definition: Intellectual Product described as international Index of Erectile Function - Over the past four weeks how much have you enjoyed sexual intercourse?", + "output": "IIEF0108 (Intellectual Product)" + }, + { + "input": "Definition: ECG Recording Quality described as an electrocardiographic recording in which one or more of the limb electrodes are disconnected resulting in missing waveforms (often flat lines) of the respective leads.", + "output": "LIMB ELECTRODE(S) DISCONNECTED (Qualitative Concept)" + }, + { + "input": "Definition: something described as interdisciplinary study dealing with the transmission of messages or signals, or the communication of information; does not directly deal with meaning or content, but with physical representations that have meaning or content; overlaps considerably with communication theory and cybernetics.", + "output": "Theories, Information (Information Sciences)" + }, + { + "input": "Definition: Investigative Techniques described as a measure of the ability of a substance, such as a food, to quench oxygen free radicals in vitro.", + "output": "Oxygen Radical Absorbance Capacity (Laboratory Procedure)" + }, + { + "input": "Definition: Study Material described as subcategory name for the eTMF domain containing a collection of documents regarding the initiation of a clinical trial.", + "output": "Trial Start Up Subcategory (Intellectual Product)" + }, + { + "input": "Definition: Automation described as the use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.", + "output": "Computer-Aided Designs (Automation)" + }, + { + "input": "Definition: something described as a family of structurally-related short-chain collagens that do not form large fibril bundles.", + "output": "Non-Fibrillar Collagens (collagen)" + }, + { + "input": "Definition: something described as the determination of the amount of S100 calcium-binding protein B present in a sample.", + "output": "S100 Calcium-Binding Protein B Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: PRDM1 gene described as human PRDM1 wild-type allele is located within 6q21-q22.1 and is approximately 24 kb in length. This allele, which encodes PR domain zinc finger protein 1, is involved in the modulation of cytokine expression. Deletion of this gene occurs in B-cell non-Hodgkin lymphoma.", + "output": "PRDM1 wt Allele (PRDM1 gene)" + }, + { + "input": "Definition: Congenital Abnormality described as premature closing of both sides of the coronal sutures.", + "output": "BRACHYCEPHALY (Congenital abnormality of skull shape)" + }, + { + "input": "Definition: Focal pedal automatism seizure described as a type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.", + "output": "Focal aware pedal automatism seizure (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the cone or head of the penis.", + "output": "Penis, Glans (Corpus Spongiosum)" + }, + { + "input": "Definition: Molecular Function described as any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).", + "output": "negative regulation of vitamin D biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: something described as a substance being studied in the treatment of some types of cancer. CDDO may block enzymes involved in inflammation and cancer growth. It is a type of antineoplastic plant product.", + "output": "CDDO acid (Cyclooxygenase Inhibitors)" + }, + { + "input": "Definition: Finding described as fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations.", + "output": "Recurrent Deceleration (Fetal heart deceleration)" + }, + { + "input": "Definition: something described as a synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. As a lipophilic agent, prinomastat crosses the blood-brain barrier. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1811\" active clinical trials using this agent.", + "output": "(3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide (Matrix Metalloproteinase Inhibitors)" + }, + { + "input": "Definition: Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage described as stage I includes: T1, N0, M0. T1: Tumor measuring 1 cm or less and is confined within the sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage I Ampulla of Vater Neuroendocrine Tumor AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Lancefield group streptococcus described as a type of bacterium often found in the vagina. It can cause systemic infections in people with suppressed immune systems.", + "output": "Streptococcus agalactiae Lehmann and Neumann 1896 (S [Preparations])" + }, + { + "input": "Definition: Pharmacologic Substance described as a analog of antimetabolite cytarabine (ara-C), with potential antineoplastic activity. Upon administration, thiarabine (T-araC) is phosphorylated to the triphosphate form T-araCTP and competes with cytidine for incorporation into DNA. This results in an inhibition of DNA replication and RNA synthesis, chain termination and may eventually decrease tumor cell proliferation. Compared to ara-C, T-araC appears to have a longer half-life and has a higher efficacy.", + "output": "4'-thio-beta-D-arabinofuranosylcytosine (pyrimidine analog)" + }, + { + "input": "Definition: Pharmacologic Substance described as the organophosphorus agent malathion.", + "output": "butanedioic acid diethyl ester (Pediculicide)" + }, + { + "input": "Definition: Parasites described as an animal or plant that gets nutrients by living on or in an organism of another species. A complete parasite gets all of its nutrients from the host organism, but a semi-parasite gets only some of its nutrients from the host.", + "output": "Parasites. (heterotroph)" + }, + { + "input": "Definition: something described as any deviation from the normal concentration of neopterin in the blood circulation. []", + "output": "Abnormal circulating neopterin concentration (Abnormal circulating nitrogen compound concentration)" + }, + { + "input": "Definition: BACTERIA AND RICKETTSIAE described as any bacteria that is not assigned to the species level but can be assigned to the Streptomyces genus level.", + "output": "Kitasatoa Matsumae and Hata 1968 (Bacterium)" + }, + { + "input": "Definition: Cytochrome P450 Family 19 described as nonEC; cytochrome P450-like enzyme which, with an NADPH-linked reductase, catalyzes the oxidative aromatization of androgens to estrogens in the placenta, ovary, and testis, and at lower levels throughout the body.", + "output": "Aromatase (Cytochrome P450 Family 19)" + }, + { + "input": "Definition: Geographic Locations described as a geographical area under the jurisdiction of a sovereign state and marked off for administrative or other purposes.", + "output": "Territory (Geographic Area)" + }, + { + "input": "Definition: Diagnostic radioisotope described as a radiotracer composed of an analog of the reversible nitric oxide synthase (NOS) inhibitor, 2-amino 4-methylpyridine, radiolabeled with fluorine F 18, with potential imaging activity upon positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 NOS, the NOS moiety targets and binds to inducible NOS (iNOS). Upon PET/CT imaging, iNOS expression and thus the extent of inflammation can be assessed. iNOS expression is upregulated in a variety of inflammatory diseases and certain cancers and may invoke a chronic inflammatory state in tumor cells.", + "output": "Fluorine-18-containing product (Radioconjugate)" + }, + { + "input": "Definition: Products and technology for education described as equipment, products, processes, methods and technology used for acquisition of knowledge, expertise or skill at any level, such as books, manuals, educational toys, computer hardware or software, not adapted or specially designed.", + "output": "General products and technology for education (Products and technology for education)" + }, + { + "input": "Definition: Congenital Abnormality described as a rare genetic subtype of non-syndromic pontocerebellar hypoplasia with characteristics of progressive cerebellum and brainstem atrophy, corpus callosum hypo/aplasia and progressive post-natal microcephaly. Patients typically present profound global developmental delay, spastic tetraparesis, seizures, cortical visual impairment and on neuroimaging abnormal brain morphology that includes pontocerebellar hypoplasia, ''figure of 8'' midbrain appearance and more variably interhemispheric cysts, ventriculomegaly and cerebral dysmyelination. There is evidence the disease is caused by homozygous mutation in the AMPD2 gene on chromosome 1p13.", + "output": "Congenital pontocerebellar hypoplasia type 9 (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Histone deacetylase inhibitor described as a substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.", + "output": "mocetinostat (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of a mutated form of the ABL1 gene. In this fusion gene there is a point mutation where adenine has been substituted with guanine at nucleotide position 827 of the ABL1 gene.", + "output": "BCR/ABL Fusion Gene with NM 005157.5:c.827A>G (BCR-ABL Fusion Gene)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study - Description of active suicidal ideation with any methods (not plan) without intent to act.", + "output": "CSS0303C (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)" + }, + { + "input": "Definition: mRNA 3'-UTR binding described as interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.", + "output": "mRNA 3'-UTR adenylate/uridylate-rich element binding (AU-rich element binding)" + }, + { + "input": "Definition: Abnormality of mucopolysaccharide metabolism described as metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans.", + "output": "Cellular metachromasia (Finding)" + }, + { + "input": "Definition: Photometric and radiometric quantities described as a unit of luminous intensity, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). It is the luminous intensity in a given direction of a small monochromatic light source at 540 terahertz emitting 1/683 watt per steradian in that direction. This is dependent upon the definitions of the meter, kilogram, and second.", + "output": "cd (Base Unit of International System of Units)" + }, + { + "input": "Definition: something described as an orthopedic manual surgical instrument is a nonpowered hand-held device intended for medical purposes to manipulate tissue, or for use with other devices in orthopedic surgery. This generic type of device includes the cerclage applier, awl, bender, drill brace, broach, burr, corkscrew, countersink, pin crimper, wire cutter, prosthesis driver, extractor, file, fork, needle holder, impactor, bending or contouring instrument, compression instrument, passer, socket positioner, probe, femoral neck punch, socket pusher, reamer, rongeur, scissors, screwdriver, bone skid, staple driver, bone screw starter, surgical stripper, tamp, bone tap, trephine, wire twister, and wrench.", + "output": "INSTRUMENT, BENDING OR CONTOURING (Medical Device)" + }, + { + "input": "Definition: Clinical Attribute described as a study to test whether certain biological agents (e.g., viruses) or materials (e.g., nucleic acids) are capable of immortalizing cells and endowing them with the capacity to form tumors.", + "output": "ONCOGENICITY (Clinical Attribute)" + }, + { + "input": "Definition: Other Anatomic Concept described as gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.", + "output": "Channels, Ion (Biologically Active Substance)" + }, + { + "input": "Definition: something described as prevention of pressure ulcers for an individual at high risk for developing them", + "output": "pressure ulcer prevention (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: acid secretion described as the controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue.", + "output": "citric acid secretion (acid secretion)" + }, + { + "input": "Definition: something described as the use of balloon CATHETERS to remove emboli by retraction of the balloon that is inflated behind the EMBOLUS.", + "output": "Balloon Embolectomies (Embolectomy)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week, how often have you: accomplished what you wanted to do?", + "output": "QLES133 (Intellectual Product)" + }, + { + "input": "Definition: Vascular Diseases described as a symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.", + "output": "IC - Intermittent claudication (GENERAL VASCULAR DISORDERS)" + }, + { + "input": "Definition: something described as catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O.", + "output": "testosterone 16-alpha-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)" + }, + { + "input": "Definition: Gastrointestinal Motility described as a pattern of gastrointestinal muscle contraction and depolarizing myoelectric activity that moves from the stomach to the ILEOCECAL VALVE at regular frequency during the interdigestive period. The complex and its accompanying motor activity periodically cleanse the bowel of interdigestive secretion and debris in preparation for the next meal.", + "output": "migrating myoelectric complex (Organ or Tissue Function)" + }, + { + "input": "Definition: Neoplastic Process described as a morphologic variant of atypical fibroxanthoma characterized by the presence of atypical mitotic figures, high mitotic activity, and pleomorphic cells.", + "output": "Classic Type Atypical Fibroxanthoma (Atypical fibroxanthoma of skin)" + }, + { + "input": "Definition: Pharmacologic Substance described as salt from Hall, upper Australia mineral springs.", + "output": "Hall Aqua / salt from Hall mineral springs in Australia (Pharmacologic Substance)" + }, + { + "input": "Definition: Neuroendocrine Tumors described as a tumor of the eye originating from cells of the retina.", + "output": "malignant retinoblastoma of eye (Neoplasms, Neuroepithelial)" + }, + { + "input": "Definition: Parenteral Route of Drug Administration described as administration of a medicinal product between the sensory retina (neural retina) and the retinal pigment epithelium of the eye.", + "output": "Subretinal route (Intraocular Route of Drug Administration)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a monoclonal antibody against the human dipeptidyl peptidase 4 (dipeptidylpeptidase IV, DPPIV, DPP4; CD26), with potential activity against graft-versus-host disease (GvHD). Upon administration, begelomab binds to CD26 expressed on T-cells. This inhibits the stimulation of T-cells and may prevent GvHD. CD26, a membrane-bound glycoprotein with dipeptidyl peptidase activity, plays a key role in T-cell activation and immune regulation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125608\" active clinical trials using this agent.", + "output": "BEGELOMAB (Selective immunosuppressants)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of galactotriose transport.", + "output": "regulation of galactotriose transport (Cell Function)" + }, + { + "input": "Definition: Caspases, Initiator described as a long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 12 is activated by pro-apoptotic factors that are released during cell stress and by CARD SIGNALING ADAPTOR PROTEINS. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.", + "output": "Caspase-12 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Protective gloves described as a surgeon's glove is a device made of natural or synthetic rubber intended to be worn by operating room personnel to protect a surgical wound from contamination. The lubricating or dusting powder used in the glove is excluded.", + "output": "SURGEON'S GLOVES (Manufactured Object)" + }, + { + "input": "Definition: Congenital Abnormality described as peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation.", + "output": "Upper limb peromelia (Aplasia/hypoplasia involving bones of the upper limbs)" + }, + { + "input": "Definition: aldehyde-lyase activity described as catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate.", + "output": "HpaI (aldehyde-lyase activity)" + }, + { + "input": "Definition: Squamous cell carcinoma described as a carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present.", + "output": "Squamous Cell Cancer (Neoplasms malignant site unspecified NEC)" + }, + { + "input": "Definition: positive regulation of tumor necrosis factor production described as any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.", + "output": "positive regulation of TNF superfamily, member 2 secretion (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a benign neoplasm arising from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath and localized giant cell tumor of tendon sheath.", + "output": "Benign Synovioma (Benign neoplasm of soft tissue)" + }, + { + "input": "Definition: something described as this gene plays a role in the proteolytic processing of proteins involved in neuronal cellular processes.", + "output": "APP SECRETASE (Gene or Genome)" + }, + { + "input": "Definition: COPING-STRESS-TOLERANCE PATTERNS described as a pattern of valid appraisal of stressors with cognitive and/or behavioral efforts to manage demands related to well-being, which can be strengthened.", + "output": "Developing individual coping (Psychological Well Being)" + }, + { + "input": "Definition: Join Code described as a coded value specifying whether, and how, a specific activity in a set of parallel activities should come together before subsequent activities can begin. EXAMPLE(S): Wait for this activity to complete before the subsequent activity; Terminate this activity as soon as all parallel \"wait\" activities are completed (and if this activity hasn't started yet, don't start it at all); Continue this activity after all \"wait\" activities complete, but don't wait for it to complete before beginning subsequent activities. OTHER NAME(S): NOTE(S):", + "output": "Defined Composition Relationship Join Code (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a unique symbol that establishes identity of the product within the context of another product. There are multiple ways in which an identifier can be associated to a product; inherited from MaterilaIdentifier.identifier, the association to ProcessedProduct.identifier, and the association to ProductRelationship.identifier. If there is no context associated with the identifier, then MaterialIdentifier.identifier should be used. However, if the identifier for a product would be different in different context, one of the other identifiers should be used. If the product is used in multiple assemblies, and in each assembly it would be assigned a different identifier, then ProductRelationship.identifier should be used. If a kind of product is produced by different processors, and each processor assigns the product a different identifier, then ProcessedProduct.identifier should be used.", + "output": "Product Relationship Identifier (Intellectual Product)" + }, + { + "input": "Definition: response to other organism described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.", + "output": "response to insects (response to other organism)" + }, + { + "input": "Definition: RouteBySite described as administration within the distal portion of the small intestine, from the jejunum to the cecum.", + "output": "Intraileal (Functional Concept)" + }, + { + "input": "Definition: Medication Management described as the distribution, sale, or transfer of a drug not pursuant to a specific prescription.", + "output": "Medication Distribution (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen described as catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O.", + "output": "estrogen 2-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus.", + "output": "response to glutathione (Organism Function)" + }, + { + "input": "Definition: Gene or Genome described as human NR5A1 wild-type allele is located in the vicinity of 9q33 and is approximately 26 kb in length. This allele, which encodes steroidogenic factor 1 protein, is involved in the activation of transcription for genes that are associated with steroid processing. Mutations in the gene are a factor in both XY sex reversal with or without adrenal failure and adrenocortical insufficiency without ovarian defect.", + "output": "Nuclear Receptor Subfamily 5, Group A, Member 1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Finding described as an abnormal conical morphology of the primary incisor.", + "output": "Conical deciduous incisor (Conical incisor)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the hematocrit corrected reticulocytes in a biological specimen.", + "output": "Hematocrit Corrected Reticulocytes (Cell Count)" + }, + { + "input": "Definition: Intellectual Product described as a legal document completed by clinical trial independent committee members disclosing any financial arrangement between the member and the sponsor(s) of a clinical study.", + "output": "Committee Member Financial Disclosure Form (Financial Disclosure Form)" + }, + { + "input": "Definition: Product Recalls and Withdrawals described as removal of a drug from the market due to a problem occurring in the manufacture or distribution of the product.", + "output": "drug recall (Regulation or Law)" + }, + { + "input": "Definition: Qualitative Concept described as used with diseases for ethnic, cultural, or anthropological aspects, and with geographic headings to indicate the place of origin of a group of people.", + "output": "EH (epidemiologic)" + }, + { + "input": "Definition: Congenital Disorders described as a syndrome, sometimes considered as three separate entities (Kalmann syndromes 1, 2, and 3), characterized mainly by reduced hypothalamic function and reduced pituitary gonadotropic activity and deficiency of gonadotropin-releasing hormone with resulting hypogonadism and absent or reduced sense of smell due to agenesis of the olfactory bulbs. Associated anomalies include cleft palate, neurosensory hearing loss, congenital heart defect, intestinal malrotation, renal agenesis, hypertension, mental retardation, color blindness, and other defects. Most abnormalities occur in types 1 and 2; type 3 is marked mainly by hypogonadotropic hypogonadism, anosmia, and craniofacial abnormalities.", + "output": "congenital anosmia-hypogonadotropic hypogonadism syndrome (Disorder of olfactory system)" + }, + { + "input": "Definition: Mitotic Anaphase described as the cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.", + "output": "mitotic anaphase A (Mitotic Anaphase)" + }, + { + "input": "Definition: Disease or Syndrome described as charcot-Marie-Tooth disease type 4 (CMT4) belongs to the genetically heterogeneous group of CMT peripheral sensorimotor polyneuropathy diseases. Type 4 is less common and often limited to certain ethnic groups. Patients present with the typical CMT phenotype along with typical features of progressive, distally accentuated weakness and atrophy of muscles innervated by the peroneal nerve in the lower limbs, followed by weakness and atrophy of hands, sensory loss, and characteristic foot abnormalities.", + "output": "Charcot-Marie-Tooth disease type 4 (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: Abnormal magnesium concentration described as abnormally high level of magnesium in the blood.", + "output": "Hypermagnesemia (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: something described as a SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).", + "output": "syntaxin-6-syntaxin-16-Vti1a complex (SNARE complex)" + }, + { + "input": "Definition: Quantitative Concept described as an index used in neuroblastic tumors indicating the presence of less than 100 mitoses and karyorrhexis per 5,000 cells.", + "output": "Low Mitosis-Karyorrhexis Index (Mitosis-Karyorrhexis Index)" + }, + { + "input": "Definition: Cancer TNM Finding by Site described as a finding about one or more characteristics of ophthalmic sites cancer, following the rules of the TNM AJCC v8 classification system.", + "output": "Ophthalmic Sites Cancer TNM Finding v8 (Cancer TNM Finding by Site)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in deubiquitination, regulation of proteasome-mediated protein degradation and chromatin remodeling.", + "output": "CGI-70 (Gene or Genome)" + }, + { + "input": "Definition: Oriental anesthesia described as any elsewhere undefined acupuncture anesthesia, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "undef.aqpnct anes.narr req' (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as the region that includes the colon and the rectum.", + "output": "Colorectal Region (Body Location or Region)" + }, + { + "input": "Definition: something described as protein which consists of beta sheets.", + "output": "Beta protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a person undergoing radiation therapy.", + "output": "Radiation Therapy Patient (Imaging Patient)" + }, + { + "input": "Definition: Functional Concept described as administration of a medicinal product directly into the anterior chamber of the eye", + "output": "INTRACAMERAL (Injection Route of Drug Administration)" + }, + { + "input": "Definition: something described as a quantity of time in which the observation result is held to be true.", + "output": "DefinedObservation.focalDuration (Focal Duration)" + }, + { + "input": "Definition: CRQ-SAS Follow-Up Administration Version Questionnaire Question described as chronic Respiratory Questionnaire Self-Administered Standardized Format Follow-Up Administration Version Questionnaire (CRQ-SAS Follow-Up Administration Version) Performing chores (such as housework, shopping groceries).", + "output": "CRQ0204 (CRQ-SAS Follow-Up Administration Version Questionnaire Question)" + }, + { + "input": "Definition: something described as catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP.", + "output": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Energy Metabolism described as a nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.", + "output": "tca cycle (Metabolic Pathway)" + }, + { + "input": "Definition: Toxoplasma infections described as passed from mother to fetus.", + "output": "Congenital Toxoplasma Infection (Congenital neonatal infections)" + }, + { + "input": "Definition: Autonomic nervous system described as nerve supply of the heart.", + "output": "heart innervation (Organ or Tissue Function)" + }, + { + "input": "Definition: Purposeful sensory experiences described as using the sense of seeing intentionally to experience visual stimuli, such as watching a sporting event or children playing.", + "output": "Watching (Purposeful sensory experiences)" + }, + { + "input": "Definition: Functional Concept described as specifies whether the design of the study is expected to evolve during the execution of the study. EXAMPLE(S): OTHER NAME(S): Adaptive Study Indicator NOTE(S):", + "output": "StudyProtocolVersion.adaptiveDesignIndicator (Functional Concept)" + }, + { + "input": "Definition: Gastrostomy described as the placement of a feeding tube through the abdominal wall into the stomach with the assistance of fluoroscopic guidance.", + "output": "Percutaneous fluoroscopic gastrostomy (Gastrostomy)" + }, + { + "input": "Definition: Pharmacologic Substance described as an element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.", + "output": "O2 - oxygen (oxygen group elements)" + }, + { + "input": "Definition: Androstanols described as a 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation.", + "output": "ETIOCHOLANOLONE (ADRENAL AND GONADAL HORMONES)" + }, + { + "input": "Definition: something described as a question about whether an individual is or was bothered by dizziness.", + "output": "Have you, during the past week, been bothered by dizziness (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Child - In the past one month, how much of a problem has this been for you: I wake up tired.", + "output": "PedsQL Neuromuscular Module Version 3.0 Child Report - Wake Up Tired (Intellectual Product)" + }, + { + "input": "Definition: something described as used with drugs, biological preparations, and physical agents for their use in the prophylaxis and treatment of disease. It includes veterinary use.", + "output": "therapeutic use (Qualitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent of Toddler (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler) In the past one month, how much of a problem has this been for your child: It is hard for my child to explain his or her illness to other people.", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent of Toddler - Hard Explain Illness to People (Intellectual Product)" + }, + { + "input": "Definition: something described as child-Pugh Classification (Child-Pugh) Prothrombin time, sec prolonged.", + "output": "CPS0105A (Child-Pugh Clinical Classification Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.", + "output": "SUMO ligase activity (SUMO transferase activity)" + }, + { + "input": "Definition: Sarcomatoid Mesothelioma described as a malignant neoplasm arising from mesothelial cells. It is characterized by the presence of a dense collagenous tissue and atypical neoplastic cells. Sarcomatoid features, collagenous necrosis, and infiltration of muscle and adipose tissue may be present. It occurs in the pleura and less commonly in the peritoneum.", + "output": "Desmoplastic Mesothelioma (Sarcomatoid Mesothelioma)" + }, + { + "input": "Definition: something described as human DAO wild-type allele is located in the vicinity of 12q24 and is approximately 42 kb in length. This allele, which encodes D-amino-acid oxidase protein, plays a role in amino acid modification. Mutation of the gene is associated with schizophrenia and may be associated with familial amyotrophic lateral sclerosis.", + "output": "D-Amino-Acid Oxidase wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as a measurement of the aggregates composed of platelets and granulocytes in a biological specimen.", + "output": "Platelet-Granulocyte Aggregate Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Tendon Injuries described as injuries to the ROTATOR CUFF of the shoulder joint.", + "output": "cuff injury rotator (Injury of musculoskeletal system)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual rode a bicycle or a stationary bike.", + "output": "Ride a Bicycle or Stationary Bike (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the result of any gain, loss or alteration of the sequences comprising a gene, including all sequences transcribed into RNA.", + "output": "MOLPATH.MUT (Laboratory Class)" + }, + { + "input": "Definition: Ligand Binding Protein Gene described as this gene may play a role in protein-protein or protein-DNA interactions.", + "output": "PWWP DOMAIN-CONTAINING PROTEIN 2A (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: inflammatory response to antigenic stimulus described as an acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.", + "output": "acute inflammatory response to antigenic stimulus (Pathologic Function)" + }, + { + "input": "Definition: Medical Device described as mechanical shields usually made of high-impact transparent plastics attached to or placed on the laboratory benches. These shields are used in clinical laboratories to protect the workers from explosions, flames, spurting liquids, and other physical or chemical reactions.", + "output": "Shields, Mechanical, Workbench (Shields, Laser)" + }, + { + "input": "Definition: Short Bowel Syndrome described as a rare intestinal disorder of neonates of unknown etiology. Patients are born with a short small bowel (less than 75 cm in length) that compromises proper intestinal absorption and leads chronic diarrhea, vomiting and failure to thrive.", + "output": "Intestinal Pseudo-Obstructions, Idiopathic (Diabetic complications gastrointestinal)" + }, + { + "input": "Definition: Carcinoma of the Appendix described as a term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix.", + "output": "Appendiceal Carcinoma by AJCC v8 Stage (Carcinoma of the Appendix)" + }, + { + "input": "Definition: Natural regeneration described as renewal or physiological repair of damaged skeletal tissue.", + "output": "musculoskeletal regeneration (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as stage IVB includes: Any T, M1b, Risk factors: high risk. M1b: All other distant metastasis.", + "output": "Stage IVB Gestational Trophoblastic Tumor (Stage IV Gestational Trophoblastic Tumor AJCC v7)" + }, + { + "input": "Definition: Geographic Area described as a country in southern South America, bordering the South Atlantic Ocean, located between Argentina and Brazil.", + "output": "UY (South America)" + }, + { + "input": "Definition: Virus Physiological Phenomena described as the process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.", + "output": "Replication, Viral (virus infection mechanism)" + }, + { + "input": "Definition: Organ or Tissue Function described as functions of the additional muscles involved in breathing.", + "output": "Functions of accessory respiratory muscles (Respiratory muscle functions)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cohesin subunit SA-1 (1258 aa, ~144 kDa) is encoded by the human STAG1 gene. This protein plays a role in the cohesion of sister chromatids.", + "output": "SA-1 protein, human (Binding Proteins)" + }, + { + "input": "Definition: Heart described as region of wall of right atrium which separates the anterior wall of right atrium from the lateral wall of right atrium and is continuous with the valve of inferior vana cava.", + "output": "Crista terminalis of right atrium (Right atrial structure)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.", + "output": "embryonic liver development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as one of five midline nuclei of the thalamus as defined in Olszewski-1952. The other nuclei in the group are the Nucleus centralis densocellularis, the Nucleus centralis latocellularis, the Nucleus centralis superior thalami, and the Nucleus centralis intermedialis. Together they constitute the central medial nucleus and the rhomboidal nucleus ( Jones-1990 ).", + "output": "Nucleus centralis inferior thalami (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: B-cell lymphomas NEC described as a type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and may be either indolent (slow-growing) or aggressive (fast-growing). There are many different types of B-cell lymphomas, and prognosis and treatment depend on the type and stage of cancer.", + "output": "lymphoma b cell (B-cell lymphomas NEC)" + }, + { + "input": "Definition: something described as stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Papillary noninvasive carcinoma. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage 0 Renal Pelvis and Ureter Urothelial Carcinoma AJCC v7 (Transitional cell carcinoma in situ)" + }, + { + "input": "Definition: Stage IVA Lip and Oral Cavity Cancer AJCC v6 and v7 described as stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip cancer with moderately advanced local disease. Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.", + "output": "Stage IVA Lip Cancer (Neoplastic Process)" + }, + { + "input": "Definition: transferase activity, transferring alkyl or aryl (other than methyl) groups described as catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate.", + "output": "AMP dimethylallyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a tumor-like nodule or mass of inflammatory granulation tissue projecting into the lumen of the LARYNX.", + "output": "Granulomas, Laryngeal (Laryngeal Diseases)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) During the last week, has it been easy or hard for your child to: Walk more than a mile?", + "output": "PODCI222 (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as compounds that contain the decamethylenebis(trimethyl)ammonium radical. These compounds frequently act as neuromuscular depolarizing agents.", + "output": "Decamethonium Compounds (Bis-Trimethylammonium Compounds)" + }, + { + "input": "Definition: Disease or Syndrome described as this is usually an oligoclonal CD8+ lymphocytic infiltration of various organs.", + "output": "Diffuse infiltra. lymph. syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Genes, Immunoglobulin described as genes and gene segments encoding the IMMUNOGLOBULIN LIGHT CHAINS. Gene segments of the light chain genes are designated as V (variable), J (joining), and C (constant).", + "output": "GENES IG LIGHT CHAIN (Gene or Genome)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 2p", + "output": "2p24.1 (Cell Component)" + }, + { + "input": "Definition: Protein Kinase Inhibitors described as a maleimide-based, small molecule inhibitor of glycogen synthase kinase-3 (GSK-3; serine/threonine-protein kinase GSK3) with potential antineoplastic activity. Upon intravenous administration, 9-ING-41 binds to and competitively inhibits GSK-3, which may lead to downregulation of nuclear factor kappa B (NF-kappaB) and decreased expression of NF-kappaB target genes including cyclin D1, B-cell lymphoma 2 (Bcl-2), anti-apoptotic protein XIAP, and B-cell lymphoma extra-large (Bcl-XL). This may inhibit NF-kappaB-mediated survival and chemoresistance in certain tumor types. GSK-3, a constitutively active serine/threonine kinase that plays a role in numerous pathways involved in protein synthesis, cellular proliferation, differentiation, and metabolism, is aberrantly overexpressed in certain tumor types and may promote tumor cell survival and resistance to chemotherapy and radiotherapy.", + "output": "9-ING-41 (Protein Kinase Inhibitors)" + }, + { + "input": "Definition: Homeopathic remedies letter P described as pellitory-of-the-wall.", + "output": "Parietaria officinalis / pellitory of the wall (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as HIV mutation in the integrase (IN) coding region", + "output": "V72I (Finding)" + }, + { + "input": "Definition: something described as neuropsychiatric Inventory (NPI) Does the patient have periods when he/she refuses to cooperate or won't let people help him/her? Is he/she hard to handle?", + "output": "NPI - Periods When He/She Refuses to Cooperate (NPI Questionnaire Question)" + }, + { + "input": "Definition: Eukaryote described as commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.", + "output": "helminths (Eukaryote)" + }, + { + "input": "Definition: something described as this gene is involved in the regulation of signal transduction.", + "output": "PROTEIN PHOSPHATASE 2B, CATALYTIC SUBUNIT, GAMMA ISOFORM, FORMERLY (Gene or Genome)" + }, + { + "input": "Definition: Cell Function described as the cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae.", + "output": "mitotic cell cycle G1 arrest in response to pheromone (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a proprietary lipid emulsion containing five vaccines: diphtheria, pertussis, tetanus (DPT), Bacille Calmette-Guerin (BCG), measles, Serratia marcescens and pneumococcal, with potential immunostimulating activity. Subcutaneous administration of the DPT/BCG/measles/Serratia/pneumococcus vaccine activates the immune system and may both abrogate tumor-induced immune tolerance and induce an antitumor immune response, which may eradicate the tumor. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120213\" active clinical trials using this agent.", + "output": "diphtheria, pertussis, tetanus/Bacille Calmette-Guerin/measles/Serratia/pneumococcus vaccine (Cancer Vaccines)" + }, + { + "input": "Definition: Internal medicine specialty described as a subspecialty of internal medicine concerned with the study of neoplasms.", + "output": "Medical oncology specialty (Medical Specialities)" + }, + { + "input": "Definition: Chickens described as domestic chicken or any other bird at any stage of development prior to hatching.", + "output": "Chick Embryo (Embryonic Structure)" + }, + { + "input": "Definition: something described as a genus of fungi in the family Neocallimasticaceae, order NEOCALLIMASTIGALES. They contain polyflagellate zoospores and grow on a range of simple and complex carbohydrates in the rumen of sheep and cattle.", + "output": "Neocallimastix (Fungus)" + }, + { + "input": "Definition: Graft vs Host Reaction described as immunological rejection of tumor tissue/cells following bone marrow transplantation.", + "output": "Responses, Graft-vs-Neoplasm (Organ or Tissue Function)" + }, + { + "input": "Definition: cell fate commitment described as the process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote.", + "output": "apical cell fate commitment (developmental process involved in reproduction)" + }, + { + "input": "Definition: something described as the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.", + "output": "Clodronate Sodium (Organic Chemical)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a variation in the amino acid sequence for cellular tumor antigen p53.", + "output": "Cellular Tumor Antigen p53 Protein Variant (Gene Product Sequence Variation)" + }, + { + "input": "Definition: Immunologic Factor described as a monoclonal antibody directed against the melanosomal membrane protein gp75 (or Tyrosinase-Related Protein 1 [TRP1]) with potential immunostimulatory and antineoplastic activities. Flanvotumab targets and binds to gp75. This may lead to the induction of cytotoxic T cell immune and antibody-mediated immune responses against melanoma cells expressing gp75. gp75, a pigmentation-associated antigen, is expressed in melanosomes of human melanocytes and melanomas. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91384\" active clinical trials using this agent.", + "output": "FLANVOTUMAB (Immunologic Factor)" + }, + { + "input": "Definition: Female genital fluids and spaces described as a slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus.", + "output": "Cervical secretion (Female genital fluids and spaces)" + }, + { + "input": "Definition: Chlamydia described as a genus of the family CHLAMYDIACEAE comprising gram-negative non CHLAMYDIA TRACHOMATIS-like species infecting vertebrates. Chlamydophila do not produce detectable quantities of glycogen. The type species is CHLAMYDOPHILA PSITTACI.", + "output": "Genus chlamydophila (Chlamydiales)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of concentration equal to liter per hour divided by kilogram per meter squared.", + "output": "(L/h)/(kg/m2) (Unit of Dose Calculation)" + }, + { + "input": "Definition: something described as documentation that presents and summarizes the findings of the pharmacokinetic (PK) data from a trial.", + "output": "Study Reports: Pharmacokinetics (Module 4: Study Reports)" + }, + { + "input": "Definition: Pharmacologic Substance described as an antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2) site-specifically conjugated, via the non-natural amino acid linker para-acetyl-phenylalanine (pAcF), to the auristatin analog and potent microtubule inhibitor monomethyl auristatin F (MMAF), with potential antineoplastic activity. Upon administration of anti-HER2 ADC ARX788, the antibody moiety targets and binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, MMAF binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. The site-specific conjugation of the cytotoxic agent to the antibody improves the biophysical properties of ARX788, increases payload stability and optimizes its efficacy.", + "output": "ARX788 (Anti-HER2 Antibody-drug Conjugate)" + }, + { + "input": "Definition: Gene Mutant described as a change in the nucleotide sequence of the AXL gene.", + "output": "UFO Gene Mutation (Receptor Tyrosine Kinase Gene Mutation)" + }, + { + "input": "Definition: Structure of subregion of trunk described as this segment relates to the volume of the trunk that is bounded by and includes: superiorly thoracic diaphragm and inferiorly the perineum and external genitalia. The volume includes the entire transverse thickness of the body over the longitudinal extent between these upper (superior) and lower (inferior) boundaries including the overlying muscles, skin and subcutaneous tissue. The segment includes the abdominopelvic cavity, contents and wall including the posterior lumbar region, the volume of the true and false pelvic cavities including the bony pelvis and pelvic wall, the entire perineum and external genitalia including skin and subcutaneous tissue.", + "output": "Lower trunk (Structure of subregion of trunk)" + }, + { + "input": "Definition: Anatomical Abnormality described as abnormal tortuous (i.e., twisted) form of the aorta.", + "output": "Aortic tortuosity (Abnormal aortic morphology)" + }, + { + "input": "Definition: Clamps, External Occlusion described as an obstetric-gynecologic specialized manual instrument is one of a group of devices used during obstetric-gynecologic procedures to perform manipulative diagnostic and surgical functions (e.g., dilating, grasping, measuring, and scraping), where structural integrity is the chief criterion of device performance. This type of device consists of the following: (1) An amniotome is an instrument used to rupture the fetal membranes. (2) A circumcision clamp is an instrument used to compress the foreskin of the penis during circumcision of a male infant. (3) An umbilical clamp is an instrument used to compress the umbilical cord. (4) A uterine curette is an instrument used to scrape and remove material from the uterus. (5) A fixed-size cervical dilator is any of a series of bougies of various sizes used to dilate the cervical os by stretching the cervix. (6) A uterine elevator is an instrument inserted into the uterus used to lift and manipulate the uterus. (7) A gynecological surgical forceps is an instrument with two blades and handles used to pull, grasp, or compress during gynecological examination. (8) A cervical cone knife is a cutting instrument used to excise and remove tissue from the cervix. (9) A gynecological cerclage needle is a looplike instrument used to suture the cervix. (10) A hook-type contraceptive intrauterine device (IUD) remover is an instrument used to remove an IUD from the uterus. (11) A gynecological fibroid screw is an instrument used to hold onto a fibroid. (12) A uterine sound is an instrument used to determine the depth of the uterus by inserting it into the uterine cavity. (13) A cytological cervical spatula is a blunt instrument used to scrape and remove cytological material from the surface of the cervix or vagina. (14) A gynecological biopsy forceps is an instrument with two blades and handles used for gynecological biopsy procedures. (15) A uterine tenaculum is a hooklike instrument used to seize and hold the cervix or fundus. (16) An internal pelvimeter is an instrument used within the vagina to measure the diameter and capacity of the pelvis. (17) A nonmetal vaginal speculum is a nonmetal instrument used to expose the interior of the vagina. (18) A fiberoptic nonmetal vaginal speculum is a nonmetal instrument, with fiberoptic light, used to expose and illuminate the interior of the vagina.", + "output": "Clamps, External Occlusion, Umbilical Cord (Medical Device)" + }, + { + "input": "Definition: something described as liters per minute (flow rate), divided by grams (weight) or milliliters per minute (flow rate), divided by milligrams (dose).", + "output": "Liter per Gram per Minute (Unit of Dose Calculation)" + }, + { + "input": "Definition: something described as a plant genus of the family PIPERACEAE that is indigenous in the Indian Malay region and cultivated in Madagascar, and the West Indies. It contains chavibetol, chavicol and cadinene. The leaf is chewed as a stimulant, antiseptic and sialogogue. The common name of betel is also used for ARECA.", + "output": "Piper rubroglandulosum (Plant)" + }, + { + "input": "Definition: Punches, Biopsy described as biopsy punches designed to excise a segment of tissue (frequently in the form of a thin disc several millimeters in diameter) from the skin intended for laboratory examination and/or test (i.e., biopsy) with minimal sample or surrounding tissue damage. These punches are typically handheld, manual instruments with a hollow sharpened tube at the distal end and a handle. Skin biopsy punches are available in a variety of sizes and diameters, and as reusable or disposable instruments; they are useful for performing biopsies of the full thickness of the skin.", + "output": "Skin Biopsy Punches (Medical Device)" + }, + { + "input": "Definition: something described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.", + "output": "SPATULA, ORTHOPEDIC (Medical Device)" + }, + { + "input": "Definition: something described as this is a breed of rabbit, not to be confused with the rodent CHINCHILLA.", + "output": "Chinchilla Rabbits (Mammal)" + }, + { + "input": "Definition: Pharmacologic Substance described as a proprietary oil-in-water emulsion specifically designed for combining protein preparations used in vaccines. SB-AS02B adjuvant contains monophosphoryl lipid A and QS21, a saponin extracted from the South American tree Quillaja saponaria Molina. This agent may be used for formulating cancer-specific vaccine preparations such as those containing MAGE-3 melanoma protein. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2810\" active clinical trials using this agent.", + "output": "SB-AS02B adjuvant (Pharmacologic Substance)" + }, + { + "input": "Definition: Inorganic Chemical described as carbonate of lime.", + "output": "calcarea carbonica/calcium c (Homeopathic remedies letter C)" + }, + { + "input": "Definition: physical symptom described as externally visible characteristics or features of a person.", + "output": "Outward Appearance (Body Constitution)" + }, + { + "input": "Definition: something described as a cardiac myxoma arising from the atrium.", + "output": "ATRIAL MYXOMA (Benign Atrial Neoplasm)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 22q", + "output": "22q11.22 (Cell Component)" + }, + { + "input": "Definition: Portuguese translation of the Medical Subject Headings described as medicinal preparations made from living organisms or their products; venoms, enzymes may be indexed with this term; typically antibiotics and chemically pure biochemicals should not be indexed with this term, also narrower terms animal extract, plant extract, immunological substance or tissue/cell preparation should be considered.", + "output": "Biological Factor (Swedish translation of the Medical Subject Headings)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine.", + "output": "Stage IVB Fallopian Tube Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Lymphocyte Activation described as the expansion of a lymphocyte population by cell division.", + "output": "lymphocyte proliferation (mononuclear cell proliferation)" + }, + { + "input": "Definition: Organism Function described as the establishment of the sex of a female organism by physical differentiation.", + "output": "female sex differentiation (Sex Differentiation)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Cancer, Somatic Mutation, Pancreatic described as molecular assay reagents intended to identify mutations in the tumor protein p53 (TP53) gene, located at chromosome 17p13.1, that encodes for a protein that acts as a tumor suppressor and induces cellular apoptosis. This inherited genetic mutation has been identified in patients with many types of cancers", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TP53 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: something described as the date and/or date and time when a last subject to participate in a clinical trial is enrolled.", + "output": "last subject in - date, time (Temporal Concept)" + }, + { + "input": "Definition: glucosamine metabolic process described as the chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.", + "output": "glucosamine catabolic process (glucosamine-containing compound catabolic process)" + }, + { + "input": "Definition: Tooth Wear described as the loss of tooth structure by mechanical forces from opposing teeth.", + "output": "Tooth attrition (Acquired Abnormality)" + }, + { + "input": "Definition: something described as alcohol Use Disorder Identification Test: Self-Report Version - How often during the last year have you failed to do what was normally expected of you because of drinking?", + "output": "ADT01-Failed to Do as Expected (AUDIT Questionnaire Question)" + }, + { + "input": "Definition: something described as the layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans.", + "output": "basal layer of collagen and cuticulin-based cuticle extracellular matrix (Cell Component)" + }, + { + "input": "Definition: something described as the transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).", + "output": "Communicable Disease Transmission (Study of epidemiology)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as the unmarried man or woman.", + "output": "Single person (Finding of marital or partnership status)" + }, + { + "input": "Definition: Drug allergens described as a substance that stimulates the production of blood cells. Colony-stimulating factors include granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and promegapoietin.", + "output": "colony stimulating factors (Drug allergens)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual played basketball, soccer, or racquetball.", + "output": "Did you play basketball, soccer, or racquetball (Intellectual Product)" + }, + { + "input": "Definition: USSR described as a country in central Asia, north of Afghanistan, between Turkmenistan and Kazakhstan.", + "output": "Republic of Uzbekistan (Commonwealth of Independent States)" + }, + { + "input": "Definition: something described as hemogen (484 aa, ~55 kDa) is encoded by the human HEMGN gene. This protein plays a role in the differentiation of hematopoietic cells.", + "output": "Hemogen (Regulatory Protein)" + }, + { + "input": "Definition: Hereditary disorder of the integument described as an inherited condition in which benign tumors develop in hair follicles on the head, chest, back, and arms. People who have this disorder may be at increased risk of developing colon or kidney cancer.", + "output": "Multiple fibrofolliculomata (Neoplastic Syndromes, Hereditary)" + }, + { + "input": "Definition: Intellectual Product described as neuropsychiatric Inventory - Does the patient have difficulty falling asleep?", + "output": "NPI - Difficulty Falling Asleep (NPI Questionnaire Question)" + }, + { + "input": "Definition: GDS-SF Questionnaire Question described as geriatric Depression Scale Short Form - Do you think it is wonderful to be alive now?", + "output": "GDS-SF - Think Wonderful to Be Alive (GDS-SF Questionnaire Question)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as an element of the rare earth family of metals. It has the atomic symbol Tb, atomic number 65, and atomic weight 158.92.", + "output": "terbium (Element, Ion, or Isotope)" + }, + { + "input": "Definition: Wound of skin described as invasion of a wound by pathogenic microorganisms.", + "output": "Wound Infections (Focal Infection)" + }, + { + "input": "Definition: something described as HAS-BLED Bleeding Risk Score (HAS-BLED) Bleeding.", + "output": "HSB0104 (HAS-BLED Clinical Classification Question)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of guanine deaminase present in a sample.", + "output": "Guanase measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: GENERAL MICROBIOLOGY EXAMINATION, CULTURE AND STAINING PROCEDURES described as a microscopy staining method that utilizes two or more colored, acidic dyes of contrasting colors. Masson trichrome is a mixture of three dyes including aniline blue, Beibrich scarlet and Weigert's iron hematoxylin. Other related, modified trichrome staining methods include Lillie's trichrome, Gomori's trichrome and Mallory's trichrome.", + "output": "Trichrome stain (Special Histology Staining Method)" + }, + { + "input": "Definition: Taxane-Pocket Binding Agent described as a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61072\" active clinical trials using this agent.", + "output": "SAGOPILONE (Epothilones)" + }, + { + "input": "Definition: Functional Concept described as specific characteristics of a sentence's construction, including such aspects as its syntax, length, and complexity. Compare SYNTAX.", + "output": "Sentence Structure (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: something described as chronic Respiratory Questionnaire Self-Administered Standardized Format (CRQ-SAS) First Administration Version - How often during the last 2 weeks did you have a feeling of fear or panic when you had difficulty getting your breath?", + "output": "CRQ-SAS First Administration Version - Feeling of Fear or Panic (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Brain Symptom Index - I am afraid of having a seizure (convulsion).", + "output": "FBRSI - I Am Afraid of Having a Seizure (FBRSI Questionnaire Question)" + }, + { + "input": "Definition: Refractory Aggressive Non-Hodgkin Lymphoma described as adult T-cell leukemia/lymphoma that is resistant to treatment.", + "output": "Refractory Adult T-Cell Leukemia/Lymphoma (Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Deformity described as abnormal enlargement of one or both hands, along with hyperhydrosis.", + "output": "Chiromegaly (Deformity)" + }, + { + "input": "Definition: something described as joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body.", + "output": "Generalized joint laxity (Limb structure)" + }, + { + "input": "Definition: something described as any agent that inhibits heat shock protein (Hsp) 90.", + "output": "Heat Shock Protein 90 Inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: regulation of cell-cell adhesion described as any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion.", + "output": "regulation of homotypic cell-cell adhesion (regulation of cell-cell adhesion)" + }, + { + "input": "Definition: something described as experimental completion date means the last date on which data are collected from the study.", + "output": "Experimental End Date (End date)" + }, + { + "input": "Definition: Biologically Active Substance described as apoptosis-stimulating of p53 protein 1 (1090 aa, ~120 kDa) is encoded by the human PPP1R13B gene. This protein plays a role in the stimulation of cellular tumor antigen p53 activity.", + "output": "apoptosis-stimulating of p53 protein 1, human (Apoptosis Regulatory Proteins)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of CD4 T cells compared to lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.", + "output": "CD4 T Cell to Lymphocyte Ratio Measurement (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Physiologic Responses described as reassesses respiratory status to determine changes from baseline throughout the perioperative phase of care.", + "output": "Evaluates respiratory status (Health Care Activity)" + }, + { + "input": "Definition: Chromosomal translocation described as a cytogenetic abnormality that refers to the translocation of chromosome 11p15 with chromosome 15q35. It results in the formation of NUP98/JARID1A fusion gene. It is associated with the development of acute myeloid leukemia with t(11;15)(p15;q35); NUP98-JARID1A.", + "output": "t(11;15)(p15;q35) (Chromosomal translocation)" + }, + { + "input": "Definition: Dyes described as a vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.", + "output": "Nuclear Fast Red (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: MTA2 gene described as human MTA2 wild-type allele is located within 11q12-q13.1 and is approximately 9 kb in length. This allele, which encodes metastasis-associated protein MTA2, is involved in the modification of chromatin.", + "output": "PID (MTA2 gene)" + }, + { + "input": "Definition: Molecular Function described as the formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein.", + "output": "C-terminal peptidyl-serine amidation (peptidyl-serine modification)" + }, + { + "input": "Definition: Class osteichthyes - bony fish described as a resident intertidal species of fish that is mainly found in saltwater marshes and tidal creeks.", + "output": "Killifish (Cyprinodontidae)" + }, + { + "input": "Definition: something described as a declaration of a relationship between entities, consisting of a subject, predicate and object.", + "output": "Entity Statement (Statement)" + }, + { + "input": "Definition: something described as a small dog in stature, but wide and compact, with a thick, massive head. The skin on the skull and forehead should fall in dense folds. The ears should be small and thin, and folded back in the form of a rose. The coat may be red, fawn, brindle, pale yellow, washed-out red, or white. The average height range is 12-16 inches and the average weight range is 49-55 pounds.", + "output": "bulldogs (Non-Sporting Breed)" + }, + { + "input": "Definition: Skeletal muscle structure of thorax described as the most superficial of the three intercostal muscles (external, internal, innermost) found in the intercostal space, which aid in both active and passive inhalation.", + "output": "External intercostal muscles (Structure of intercostal muscle)" + }, + { + "input": "Definition: regulation of coenzyme metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme.", + "output": "negative regulation of coenzyme metabolism (regulation of coenzyme metabolic process)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Did {S} talk about events outside home involving family, friends, or neighbors?", + "output": "ADL0312B (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: Laboratory or Test Result described as a microbial susceptibility test result in which the growth of microorganisms may be inhibited by the usually achievable concentrations of antimicrobial agent when the recommended dosage is used for the site of infection. The response rates may be lower than for susceptible isolates.", + "output": "Intermediate (Laboratory or Test Result)" + }, + { + "input": "Definition: Inverted T wave described as t wave inversion in leads v2-5.", + "output": "Anterior T wave inversion (Inverted T wave)" + }, + { + "input": "Definition: Intellectual Product described as suicidal Ideation Questionnaire (SIQ) I thought that killing myself would solve my problems.", + "output": "SIQ0114 (SIQ Questionnaire Question)" + }, + { + "input": "Definition: STRUCTURAL DYSFUNCTION described as collapse of all or part of a lung due to bronchial plugging or the chest cavity being opened to atomspheric pressure.", + "output": "Pulmonary collapse with atelectasis (respiratory obstructive disorders)" + }, + { + "input": "Definition: something described as a form of ectodermal dysplasia syndrome with characteristics of trichodysplasia, with absent eyebrows and eyelashes, onychodysplasia, mild retrognathia, abnormal dermatoglyphics (excess of whorls on fingertips, radial loop on finger, hypothenar pattern), intellectual disability and normal teeth and sweating. Additional variable manifestations include high implanted or prominent ears, mild hearing loss, supernumerary nipple, caf\u00e9-au-lait spots, keratosis pilaris, and irregular menses. To date, four individuals from 2 generations of a consanguineous family of Portuguese descent have been described in the literature. Males and females were equally affected. Hidrotic ectodermal dysplasia, Halal type is inherited in an autosomal recessive manner.", + "output": "Hidrotic ectodermal dysplasia Halal type (Ectodermal dysplasia with hair-nail defect)" + }, + { + "input": "Definition: something described as a water-soluble, nano-sized formulation composed of nanoparticles encapsulating the poorly water-soluble curcumin, a signal transducer and activator of transcription 3 (Stat3), nuclear factor Kappa B (NF-kB) and poly-tyrosine kinase inhibitor (TKI), and the antineoplastic anthracycline antibiotic doxorubicin, with potential antineoplastic activity. Upon administration of the curcumin/doxorubicin-encapsulating nanoparticle IMX-110, the curcumin moiety targets and inhibits the activation of STAT3 and NF-kB and prevents STAT3- and NF-kB-mediated signaling pathways, both of which are activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, tumor resistance to apoptosis, metastasis and immune evasion. The doxorubicin moiety intercalates into DNA and interferes with topoisomerase II activity. This inhibits DNA replication and RNA synthesis, leading to tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and curcumin, by inhibiting NFkB and STAT3 activity, may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells. Chemotherapeutic agents, such as doxorubicin, upregulate the expression of NF-kB in tumor cells which generates chemotherapy-resistant tumor cells.", + "output": "IMX110 (Doxorubicin Preparation)" + }, + { + "input": "Definition: Manufactured Object described as simulators designed for training in one or more of particular clinical or surgical procedures that usually include a human anatomic model, either of the whole body (i.e., a manikin) or a partial model for a particular anatomic part, such as a head, torso, or an extremity according to the procedure to be trained. Training simulators also include a set of devices that permit the simulated training in the performance of the procedure as close as possible to the real activity. Training simulators intended for a variety of purposes, such as learning device functioning (e.g., external defibrillators), therapeutic procedures (e.g., ophthalmic, intravenous infusion), surgical and/or endoscopic procedures (e.g., arthroscopy, laparoscopy), monitoring (e.g., hemodynamic status), and other procedures are available. The simulators facilitate the training of healthcare personnel with less need for practice on human beings or animal models.", + "output": "Training Simulators (Manufactured Object)" + }, + { + "input": "Definition: Organism Attribute described as an individual who does not conform to a male/female gender identity.", + "output": "Gender Variant (Gender)" + }, + { + "input": "Definition: Dietary Supplements described as a nutritional supplement containing a proprietary mix of amino acids and electrolytes, with potential rehydrating and gastrointestinal (GI) supportive activities. Upon oral administration of the amino acid-electrolyte dietary supplement, the electrolytes are transported by amino acid-coupled transporters across the intestinal epithelial barriers. This helps rehydrate the intestinal epithelial cells, helps restore normal bowel function, prevents fluid loss and improves symptoms of diarrhea. In addition, the supplement helps restore the size and functioning of the damaged villi and facilitates the restoration of the intestinal cells, thereby helping to restore and increase nutrient absorption, restoring normal bowel function and supporting healthy immune function.", + "output": "amino acid/electrolyte-coupled transport supplement (Food)" + }, + { + "input": "Definition: Disease or Syndrome described as a focal cognitive seizure with conduction dysphasia / aphasia characterized by retained awareness throughout the seizure.", + "output": "Focal aware cognitive seizure with conduction dysphasia/aphasia (Focal aware cognitive seizure)" + }, + { + "input": "Definition: Afferent Pathways described as set of cell bodies and nerve fibers conducting impulses from the eyes to the cerebral cortex. It includes the RETINA; OPTIC NERVE; optic tract; and geniculocalcarine tract.", + "output": "visual pathway (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Esophagus and Esophagogastric Junction Cancer Pathologic TNM Finding v7 described as a pathologic finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for esophagus and esophagogastric junction cancer.", + "output": "Esophagus and Esophagogastric Junction Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.", + "output": "status; epilepticus, focal motor (Status epilepticus with prominent motor symptoms)" + }, + { + "input": "Definition: something described as the orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis.", + "output": "epithelial cell migration involved in nephron tubule morphogenesis (Cell Function)" + }, + { + "input": "Definition: Disease or Syndrome described as diseases due to or propagated by body fluids from hosts whose BLOOD has been contaminated with pathogens.", + "output": "Disease, Blood Borne (Disease or Syndrome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a post-translationally modified form of histone H3 where the lysine residue at position 4 is dimethylated. This modification may be a marker for transcriptionally active genes.", + "output": "H3K4me2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a rare primary immunodeficiency caused by homozygous CD70 mutation. It is characterized by susceptibility to Epstein-Barr virus infection, hypogammaglobulinemia, and development of B-cell non-Hodgkin lymphomas and Hodgkin lymphomas.", + "output": "LPFS3 (Disease or Syndrome)" + }, + { + "input": "Definition: Sensorineural Hearing Loss described as syndrome is characterised by the combination of sensorineural hearing loss, early greying of scalp hair and adult onset essential tremor. It has been described in three unrelated individuals. Additional family members in each family showed varied expression of these three signs. The syndrome appears to be autosomal dominant with variable penetrance but the causative mutation has not yet been identified.", + "output": "Sensorineural hearing loss, early greying, essential tremor syndrome (Auditory system hereditary disorder)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a monitor code. Use associated HCPCS II codes to bill for monitor(s). This code is used for scope-of-practice mapping, not for billing.", + "output": "Non-specified HCPCS II monitor reference code no charge (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: Injury or Poisoning described as fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).", + "output": "FRACTURES OF THE SKULL (Skull Fractures)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process.", + "output": "upregulation of androst-4-ene-3,17-dione formation (positive regulation of hormone biosynthetic process)" + }, + { + "input": "Definition: Unit of Radioactive Decay described as a unit of radioactive decay expressed in atoms of radioactive material that decay over a period of time equal to sixty seconds in a mass unit equal to one centigram.", + "output": "Disintegration per Minute per 100 milligrams (Unit of Radioactive Decay)" + }, + { + "input": "Definition: regulation of cell-substrate junction organization described as any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.", + "output": "regulation of focal adhesion disassembly (regulation of cell-substrate junction organization)" + }, + { + "input": "Definition: Ubiquitin-Transferase Gene described as this gene plays a role in the regulation of protein degradation.", + "output": "SIAH2 gene (Ubiquitin-Transferase Gene)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a kininogen of low molecular mass.", + "output": "LK binding (kininogen binding)" + }, + { + "input": "Definition: Cell division phases described as a measure of the percentage of cells in a tumor that are in the phase of the cell cycle during which DNA is synthesized. The S-phase fraction may be used with the proliferative index to give a more complete understanding of how fast a tumor is growing.", + "output": "mitotic index (Cytogenetic Analysis)" + }, + { + "input": "Definition: Gastric Gastrointestinal Stromal Tumor described as stage IIIA includes: T3, N0, M0, Mitotic rate: High. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IIIA Gastric (Stomach) Gastrointestinal Stromal Tumor (Neoplastic Process)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent of Toddler (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler) In the past 7 days, how much of a problem has this been for your child: My child gets sores and/or rashes.", + "output": "PQL1803 (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)" + }, + { + "input": "Definition: Actin-Binding Protein described as one of the minor protein components of skeletal and cardiac muscles. It functions as the calcium-binding component in a complex with BETA-TROPOMYOSIN; ACTIN; and MYOSIN and confers calcium sensitivity to the cross-linked actin and myosin filaments. Troponin itself is a complex of three regulatory proteins (TROPONIN C; TROPONIN I; and TROPONIN T).", + "output": "Troponin Complex (Proteins)" + }, + { + "input": "Definition: something described as a complete description of each unique treatment regimen to uniformly group patients for separate analysis of adverse events and response data.", + "output": "Treatment Assignment Description (Intellectual Product)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 2 of the coding sequence of the B2M gene where thymine has been mutated to guanine.", + "output": "B2M c.2T>G (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Leishmania major species complex described as intracellular parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes cutaneous ulcer form of leishmaniasis; transmission is by Phlebotomus sandflies; found in north and central Africa, Middle East, and southern Asia.", + "output": "Leishmania majors (Genus: Leishmania)" + }, + { + "input": "Definition: coumarin metabolic process described as the chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids.", + "output": "coumarin anabolism (coumarin metabolic process)" + }, + { + "input": "Definition: Pulmonary Fibrosis, CTCAE described as life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing", + "output": "Grade 4 Pulmonary Fibrosis, CTCAE (Pulmonary Fibrosis, CTCAE)" + }, + { + "input": "Definition: Rab GTPase binding described as stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.", + "output": "Rab guanyl-nucleotide exchange factor activity (Ras guanyl-nucleotide exchange factor activity)" + }, + { + "input": "Definition: Gene or Genome described as the human MIR376A1 wild-type allele is located in the vicinity of 14q32.31 and is approximately 67 bases in length. This allele, which encodes MIR376A1 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with epithelial ovarian cancer.", + "output": "hsa-mir-376a-1 (MIR376A1 gene)" + }, + { + "input": "Definition: something described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.", + "output": "STAIN, TRICHROME, MALLORY'S (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: PTPRT gene described as human PTPRT wild-type allele is located within 20q12-q13 and is approximately 1117 kb in length. This allele, which encodes receptor-type tyrosine-protein phosphatase T protein, is involved in the dephosphorylation of protein-tyrosine phosphates.", + "output": "RPTPrho (PTPRT gene)" + }, + { + "input": "Definition: Embryonic Structure described as an opening between the laryngotracheal tube and the pharynx found in the early embryo, which will form to the definitive laryngeal inlet.", + "output": "Primordial Laryngeal Inlet (Other Embryologic Structure)" + }, + { + "input": "Definition: something described as facilities for the preparation of the dead for burial or cremation, for the viewing of the body, and for funeral services.", + "output": "Funeral parlour (Non-Medical Public and Private Facilities)" + }, + { + "input": "Definition: Physical Phenomenon or Property described as the formation of a quaternary compound.", + "output": "Quaternization (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Stemonaceae described as a plant genus of the family Stemonaceae. Members contain STILBENES and phenyl BENZOFURANS.", + "output": "Stemona Lour. (Stemonaceae)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions and duplications in genes associated with syndromic hearing loss and deafness, a collection of genetic hearing loss and deafness diseases that occur in parallel with signs and symptoms of syndromes affecting other parts of the body. Genetic variants at multiple loci have been associated with syndromic hearing loss/deafness. These reagents are intended to detect deletions and duplications in multiple syndromic hearing loss and deafness-associated loci simultaneously.", + "output": "Comprehensive Syndromic Hearing Loss Gene Deletion/Duplication Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Tissue Flap Breast Reconstruction described as a type of breast reconstruction in which blood vessels called deep inferior epigastric perforators (DIEP), and the skin and fat connected to them are removed from the lower abdomen and used for reconstruction. Muscle is left in place.", + "output": "DIEP flap (Tissue Flap Breast Reconstruction)" + }, + { + "input": "Definition: Biologically Active Substance described as ubiquitous intracellular protein which, when covalently attached to other proteins, marks them for degradation or targeted transport.", + "output": "Ubiquitinated (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as restoring, to the extent possible, the natural anatomical structure", + "output": "Repair (Surgical action)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual has or had pain when moving their arm on the side of their breast surgery.", + "output": "Movement of my arm on this side is painful (Intellectual Product)" + }, + { + "input": "Definition: Sex determination described as the sex determination process that results in the initial specification of sexual status of an individual organism.", + "output": "primary sex determination (Organism Function)" + }, + { + "input": "Definition: E-TRIP Clinical Classification Question described as emory Treatment Resistance Interview for PTSD - Total points.", + "output": "ETRP0103 (Intellectual Product)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormal morphology of the distal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.", + "output": "Bullet-shaped distal phalanx of the 3rd toe (Bullet-shaped 3rd toe phalanx)" + }, + { + "input": "Definition: something described as stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage IIB Fallopian Tube Cancer (Stage II Fallopian Tube Cancer AJCC v8)" + }, + { + "input": "Definition: Chronic Lymphocytic Leukemia- Binet Staging System described as findings: Lymphocytosis only; Survival (months): more than 120.", + "output": "Stage A Chronic Lymphocytic Leukemia (Neoplastic Process)" + }, + { + "input": "Definition: Quantitative Concept described as the standard deviation in a group of values that represent the cell density.", + "output": "Standard Deviation of Cell Density (Quantitative Concept)" + }, + { + "input": "Definition: General signs and symptoms NEC described as return of spontaneous circulation after cessation of CARDIOPULMONARY RESUSCITATION.", + "output": "Autoresuscitation (Organ or Tissue Function)" + }, + { + "input": "Definition: Unit of Mass Density described as a unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters.", + "output": "mg% (Quantitative Concept)" + }, + { + "input": "Definition: Helix-Loop-Helix Motifs described as forming a single Ca2+-binding site in many calcium-binding proteins, the basic EF-Hand Domain consists of a conserved 12-residue loop region between two perpendicular 10-12 residue alpha helices (helix-loop-helix). Ca2+ interacts with loop residues in a pentagonal bipyramidal configuration; each loop residue is important for Ca2+ coordination. Loop residues 1, 3, 5, 7, 9, and 12 (invariant Glu or Asp) are directly necessary for Ca2+ binding. Amino-acid variations at positions 1, 3, 5, 7, and 9 alter ion affinity. Single or multiple domains cause structural/functional variations. EF-hand Proteins are grouped into either regulatory/signaling or structural/buffering/transport categories. Ca2+ binding to regulatory proteins induces conformational/functional change; Ca2+ binding to structural proteins seems to provide a Ca2+ buffer.", + "output": "EF Hand Motif (Helix-Loop-Helix Motifs)" + }, + { + "input": "Definition: something described as the analysis of the methylated deoxyribonucleotides present in the genome in a biological sample.", + "output": "DNA Methylation (Molecular Biology Research Technique)" + }, + { + "input": "Definition: CEA Family Gene described as this gene plays a probable role in both cell-cell signaling and cell adhesion.", + "output": "CD66c (Gene or Genome)" + }, + { + "input": "Definition: Biologically Active Substance described as a nucleoside in which THYMINE is linked to DEOXYRIBOSE.", + "output": "deoxyribosylthymine (T [Preparations])" + }, + { + "input": "Definition: Intellectual Product described as a visual representation of the national cancer burden. These maps display cancer mortality data by county and state economic regions across the country. They are color coded to distinguish between regions with high, intermediate, and low rates of cancer mortality.", + "output": "Mortality Map (Intellectual Product)" + }, + { + "input": "Definition: Vascular graft stenosis described as narrowing of the lumen of an arteriovenous graft.", + "output": "Arteriovenous graft stenosis (Arteriovenous graft occlusion)" + }, + { + "input": "Definition: Intellectual Product described as one or more sponsor-defined characters used to identify, name, or characterize the concomitant medication.", + "output": "Concomitant Medication Use Sponsor Defined Identifier (Sponsor ID)" + }, + { + "input": "Definition: something described as an orally bioavailable small molecule with potential antineoplastic activity. Foretinib binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling.", + "output": "1,1-cyclopropanedicarboxamide, N-[3-fluoro-4-([6-methody-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl) (Protein-tyrosine kinase inhibitor)" + }, + { + "input": "Definition: Skeletal described as a heterogeneous group of bone dysplasias, the common character of which is stippling of the epiphyses in infancy. The group includes a severe autosomal recessive form (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC), an autosomal dominant form (Conradi-Hunermann syndrome), and a milder X-linked form. Metabolic defects associated with impaired peroxisomes are present only in the rhizomelic form.", + "output": "Chondrodystrophia Calcificans Congenita (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: something described as a benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.", + "output": "Pramipexol (Organic Chemical)" + }, + { + "input": "Definition: positive regulation of chromosome organization described as any process that activates or increases the frequency, rate or extent of kinetochore assembly.", + "output": "up regulation of kinetochore assembly (Cell Function)" + }, + { + "input": "Definition: Other Embryologic Structure described as the membrane covering the embryonic cloaca; it is composed from ectoderm and endoderm, and, following cloacal folding during embryonic development, the membrane ruptures and is absorbed, becoming continuous with the rectum.", + "output": "Cloacal Membrane (Cloaca Chamber)" + }, + { + "input": "Definition: Disease or Syndrome described as pathological or traumatic discontinuity of the cochlea or loss of function of the cochlea.", + "output": "cochlear lesion (Labyrinthine disorder)" + }, + { + "input": "Definition: something described as any viral organism that can be assigned to the Human Parainfluenza virus 2 serotype.", + "output": "Acute Laryngotracheo-Bronchitis Virus (Human parainfluenza viruses)" + }, + { + "input": "Definition: something described as an abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.", + "output": "Subsarcolemmal accumulations of abnormally shaped mitochondria (Anatomical Abnormality)" + }, + { + "input": "Definition: Hereditary Connective Tissue Disorder described as a rare craniosynostosis syndrome with characteristics of scaphocephaly, macrocephaly, severe maxillary retrusion, and mild intellectual disability. It has been reported in 11 patients from a three-generation family. The patients had variable dysmorphic features including high forehead, marked midface hypoplasia with severe maxillary retrusion, relative or absolute prognathism, and malocclusion. More severely affected patients were male and had intellectual disability. Molecular analysis revealed a K526E mutation of the fibroblast growth factor receptor 2 gene FGFR2.", + "output": "Scaphocephaly, macrocephaly, maxillary retrusion, intellectual disability syndrome (Hereditary Connective Tissue Disorder)" + }, + { + "input": "Definition: something described as hours times nanomoles per liter (area under the curve), divided by kilograms (weight) or hours times picomoles per liter (area under the curve), divided by grams (weight).", + "output": "Hour Times Nanomole Per Liter Per Kilogram (Quantitative Concept)" + }, + { + "input": "Definition: cardiac myofibril assembly described as the process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.", + "output": "ventricular cardiac myofibril development (cardiac myofibril assembly)" + }, + { + "input": "Definition: something described as any fungal organism that can be assigned to the species Meyerozyma guilliermondii.", + "output": "Meyerozyma guilliermondii (Pichia)" + }, + { + "input": "Definition: Hydroxybenzoates described as a flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).", + "output": "4 Hydroxy 3 methoxybenzoic Acid (Hydroxybenzoates)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as using fingers on psychoneural points of a client's body part, region or full body to enhance his or her emotional balance. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.", + "output": "Tch4Hlth bsk BioKnetx ea.15m (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Dimension Point of Origin described as the point within the equipment from which definition of equipment capacity originates. EXAMPLE(S): bottom left corner, upper left corner OTHER NAME(S): NOTE(S):", + "output": "StorageEquipment.dimensionPointOfOrigin (Spatial Concept)" + }, + { + "input": "Definition: Clinical Study by Phase described as phase 2. Controlled clinical studies conducted to evaluate the effectiveness of the drug for a particular indication or indications in patients with the disease or condition under study and to determine the common short-term side effects and risks associated with the drug. NOTE: Phase 2 studies are typically well controlled, closely monitored, and conducted in a relatively small number of patients, usually involving no more than several hundred subjects. [After FDA CDER Handbook, ICH E8]", + "output": "phase ii clinical trial (Clinical Trials)" + }, + { + "input": "Definition: TRANSCRIPTION FACTOR described as a protein complex that is involved in the elongation of RNA transcripts.", + "output": "TF-SIII (Protein or Riboprotein Complex)" + }, + { + "input": "Definition: positive regulation of secondary metabolite biosynthetic process described as any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process.", + "output": "upregulation of arugosin biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Porphyrin and porphyrin derivative described as a synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size.", + "output": "meta-tetrahydroxyphenyl chlorin (Sensitizers used in photodynamic/radiation therapy)" + }, + { + "input": "Definition: Infection described as a pathologic process consisting of the formation and discharge of pus.", + "output": "Suppurative (Inflammation)" + }, + { + "input": "Definition: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines described as catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea.", + "output": "proclavaminic acid amidino hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Qualitative Concept described as leaving no doubt; not open to question.", + "output": "Unequivocal (Qualitative Concept)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).", + "output": "3',5'-cAMP metabolism (Molecular Function)" + }, + { + "input": "Definition: Combined Modality Therapy described as intravenous administration of a photosensitizing agent which selectively concentrates in cancer cells, followed by exposure of the tumor to laser light of a specific wavelength; the resulting cytotoxic free radicals destroy the tumor.", + "output": "Photochemotherapy [Ambiguous] (neoplasm/cancer radiation therapy)" + }, + { + "input": "Definition: something described as compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.", + "output": "Depsipeptides (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: TF gene described as human TF wild-type allele is located in the vicinity of 3q22.1 and is approximately 32 kb in length. This allele, which encodes serotransferrin protein, is involved in the regulation of iron transport.", + "output": "HEL-S-71p (TF gene)" + }, + { + "input": "Definition: Finding described as a reduced concentration of inhibin B in the blood.", + "output": "Decreased inhibin B level (Abnormal circulating inhibin level)" + }, + { + "input": "Definition: something described as manipulating ideas, concepts or images by guessing or assuming something based on incomplete facts or information.", + "output": "Speculating (Thinking, function)" + }, + { + "input": "Definition: Disease or Syndrome described as an acute episode of pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.", + "output": "Acute aspiration pneumonia (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the lymph nodes located immediately posterior to the ear.", + "output": "Retroauricular Lymph Node (Cervical lymph node group)" + }, + { + "input": "Definition: Hematology described as a hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.", + "output": "PLASMA THROMBOPLASTIN ANTECEDENT DEFICIENCY (Coagulation factor deficiency syndrome)" + }, + { + "input": "Definition: GDS Questionnaire Question described as geriatric Depression Scale - Is it hard for you to get started on new projects?", + "output": "GDS0120 (GDS Questionnaire Question)" + }, + { + "input": "Definition: Phosphorylation Site described as it refers to amino acid serine residue that was covalently modified by phosphate group (PO4-).", + "output": "Serine Phosphorylation Site (Amino Acid Sequence)" + }, + { + "input": "Definition: Gene or Genome described as human EPS15 wild-type allele is located in the vicinity of 1p32 and is approximately 165 kb in length. This allele, which encodes epidermal growth factor receptor substrate 15 protein, plays a role in the modulation of endocytosis and is essential for epidermal growth factor receptor internalization.", + "output": "AF1P (Gene or Genome)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as personal characteristic or state of being receptive to hypnosis.", + "output": "Susceptibility (Personality Traits)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of autophagic cell death.", + "output": "regulation of autophagic cell death (Cell Function)" + }, + { + "input": "Definition: Organic Chemical described as the disulfate salt of the stable p-toluene-sulfonate complex of s-adenosyl-L-methionine (SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active compound SAMe within cells. Although the mechanism of action is largely unknown, SAMe attenuates experimental liver damage and prevents experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver; SAMe deficiency is associated with chronic liver disease-associated decreases in the activity of methionine adenosyltransferase 1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in methionine catabolism.", + "output": "S-adenosylmethionine Tosylate Disulfate (Organic Chemical)" + }, + { + "input": "Definition: something described as solid sterile preparation consisting of one or more powders intended to be dissolved in the specified liquid to obtain a solution for injection/skin-prick test.", + "output": "Powder for Solution for Injection/Skin-Prick Test Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Rhinovirus described as species of APHTHOVIRUS causing upper respiratory tract infection in horses.", + "output": "Equine Rhinovirus type 1 (Rhinovirus)" + }, + { + "input": "Definition: something described as a clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition.", + "output": "clathrin-dependent endocytosis involved in vitellogenesis (Physiologic Function)" + }, + { + "input": "Definition: Biologic Function described as any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.", + "output": "regulation of biomineral tissue development (regulation of biomineralization)" + }, + { + "input": "Definition: Resectable Malignant Liver Neoplasm described as hepatoblastoma amenable to surgical removal.", + "output": "Resectable Hepatoblastoma (Neoplastic Process)" + }, + { + "input": "Definition: Family Lymnaeidae described as a genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.", + "output": "Lymnaea (Snails)" + }, + { + "input": "Definition: something described as problem associated with the failure of the device which is unable to regain a standard level of accuracy when performing a calibration procedure or process designed to assure the accuracy and proper performance of the device.", + "output": "Recalibrate, Failure To (Medical Device Failure to Calibrate)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a monoclonal antibody against the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the anti-TIM-3 monoclonal antibody LY3321367 binds to TIM-3 expressed on certain T cells, including tumor-infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific T lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is associated with tumor-mediated immune suppression. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C137820\" active clinical trials using this agent.", + "output": "LY 3321367 (Immunologic Factor)" + }, + { + "input": "Definition: something described as positive and Negative Syndrome Scale (PANSS) Temperature - Somatic concern.", + "output": "PANSS115 (PANSS Clinical Classification Question)" + }, + { + "input": "Definition: Heterotrimeric G Protein Subunit Gene described as this gene is involved in signal transduction and negative regulation of synaptic transmission.", + "output": "guanine nucleotide binding protein (G protein), beta polypeptide 1 (Heterotrimeric G Protein Subunit Gene)" + }, + { + "input": "Definition: something described as the analysis of all of the epigenetic DNA modifications in the genome a biological sample.", + "output": "Epigenetic Analysis (Molecular Biology Research Technique)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.", + "output": "negative regulation of protein localization to cilium (negative regulation of cellular protein localization)" + }, + { + "input": "Definition: something described as an abnormal distribution of N-acylglycines in the urine. There are numerous different N-acylglycines, and this term refers to pathological alterations in their level or distribution.", + "output": "Abnormal urinary acylglycine profile (Finding)" + }, + { + "input": "Definition: Other disorders of urethra described as a benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.", + "output": "urethral caruncle (Urethral Diseases)" + }, + { + "input": "Definition: something described as the series of events in which a stimulus from a nematode is received and converted into a molecular signal.", + "output": "perception of nematode (Cell Function)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of anastrozole and ribociclib that may be used as a treatment for hormone receptor (HR)-positive advanced or metastatic breast cancer.", + "output": "Anastrozole/Ribociclib (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Adaptor Signaling Protein Gene described as this gene is involved in intracellular signaling.", + "output": "GRB2 Associated Binding Protein 1 Gene (Gene or Genome)" + }, + { + "input": "Definition: Scalpel handle described as knife/scalpel handles designed to hold and manipulate a very small cutting or dissecting blade appropriate for microsurgical procedures. These devices typically consist of a straight, reusable handheld instrument made of either metal or plastic, with an appropriate shape for easy manipulation and a distal tip that can hold a microsurgical disposable blade with a mechanism for rapid blade exchange. The combination of the handle and the attached blade results in a microsurgical knife/scalpel.", + "output": "Knife/Scalpel Handles, Microsurgery (Scalpel handle)" + }, + { + "input": "Definition: Embolization, Therapeutic described as administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.", + "output": "Chemoembolization, Therapeutic (Embolization, Therapeutic)" + }, + { + "input": "Definition: Medical Device described as devices designed to simultaneously direct the placement of the drill hole and protect the surrounding tissue.", + "output": "Guides, Drill (Guide device)" + }, + { + "input": "Definition: Medical Device described as dental pins designed for insertion in the healthy dentine of a tooth to provide retention and/or stabilization (i.e., scaffolding) for dental restorations. These pins are typically small-diameter metal (e.g., stainless steel, titanium) cylinders, usually in a range of 1.0 to 3.2 mm (0.04 to 0.125 inch) that are inserted in a previously drilled hole in the tooth and fixed by either cement and/or threading or friction. A cylindrical hole with a beveled top is predrilled in the tooth to receive the threaded end of the pin; pins with a diameter larger than the accommodating hole may be fixed by friction alone. The upper part of the pin provides a surface for securely attaching the restoration (e.g., a reconstructed coronal portion) to the tooth. Larger devices intended for insertion into the root canal are called dental posts.", + "output": "Pins, Dental Retention (Dental Equipment and Supplies)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgical incisions made in the esophagus via an endoscopic procedure.", + "output": "Peroral Endoscopic Myotomy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Flavoproteins described as a flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.", + "output": "Reduced nicotinamide adenine dinucleotide dehydrogenase (Enzyme)" + }, + { + "input": "Definition: something described as a group of transcription factors that were originally described as being specific to ERYTHROID CELLS.", + "output": "Nuclear Factors, Erythroid-Specific (Biologically Active Substance)" + }, + { + "input": "Definition: Neoplastic Process described as a germ cell tumor that arises in the pineal region. Representative examples include teratoma, germinoma, and choriocarcinoma.", + "output": "Pineal Germ Cell Tumor (Pineal Gland Neoplasm)" + }, + { + "input": "Definition: something described as the presence of ovarian and testicular tissue in the an individual with 46,XY karyotype. The anatomical expression of this condition is variable.", + "output": "46,XY True Hermaphroditism (Congenital Abnormality)" + }, + { + "input": "Definition: therapeutic autologous lymphocytes described as a preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T-cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.", + "output": "Autologous CAR2 Anti-CD38 A2 T-lymphocytes (Cell)" + }, + { + "input": "Definition: Alkylating Drug [EPC] described as a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier.", + "output": "1-(2-chloroethyl)-3-cyclohexylnitrosourea (Nitrosoureas, antineoplastic alkylating agents)" + }, + { + "input": "Definition: regulation of oxidative phosphorylation uncoupler activity described as any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity.", + "output": "negative regulation of oxidative phosphorylation uncoupler activity (negative regulation of transporter activity)" + }, + { + "input": "Definition: SPECIFIC SUBSTANCE CHEMISTRY TESTS described as analyzing a client/patient's blood sample to assess LDL levels. Service is billed per test.", + "output": "LDL cholesterol measurement (Low density lipoprotein measurement)" + }, + { + "input": "Definition: Cell Adhesion Molecules described as integrin alpha-6 (1130 aa, ~127 kDa) is encoded by the human ITGA6 gene. This protein plays a role in both cell adhesion and laminin binding.", + "output": "CD49f Antigen (Biologically Active Substance)" + }, + { + "input": "Definition: empirical study described as a study in which the subject with the condition under study (the case) is compared against a theoretical/historical model of distribution that serves as a control.", + "output": "case studies (Report)" + }, + { + "input": "Definition: something described as auditory Verbal Learning Test - List A, Word 13.", + "output": "AVL02-List A Word 13 (Intellectual Product)" + }, + { + "input": "Definition: Communication described as informational content of communications transmitted between persons or systems.", + "output": "message (Intellectual Product)" + }, + { + "input": "Definition: Islands in region of Portugal described as a group of nine islands and several islets belonging to Portugal in the north Atlantic Ocean off the coast of Portugal. The islands are named after the acores, the Portuguese for goshawks, living there in abundance.", + "output": "The Azores (Portugal)" + }, + { + "input": "Definition: Body tissue described as any of the tissues that contain hematopoietic cells and/or lymphocytes and immune system cells.", + "output": "HEMOLYMPHORETICULAR TISSUE (Body tissue)" + }, + { + "input": "Definition: Abnormal spatial orientation of the cardiac segments described as abnormality of the spatial relationship of the atria to other components of the heart.", + "output": "Abnormal atrial arrangement (Congenital abnormality of atria and atrial septum)" + }, + { + "input": "Definition: something described as brief Pain Inventory (BPI) Other methods I use to relieve pain include; distraction.", + "output": "BPI131D (BPI Questionnaire Question)" + }, + { + "input": "Definition: LABORATORY ABNORMALITIES described as a diffuse form of amyloidosis.", + "output": "Generalized amyloid deposition (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: something described as a condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets. Myelosuppression is a side effect of some cancer treatments. When myelosuppression is severe, it is called myeloablation.", + "output": "Bone marrow suppression (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, preladenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.", + "output": "7H-Pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)- (Organic Chemical)" + }, + { + "input": "Definition: Cardinal cell part described as cell part which consists of parts of the cytoplasm and plasma membrane protruding from the cell body. Examples: cilium, microvillus, axon.", + "output": "Cell appendage (Cell segment)" + }, + { + "input": "Definition: Tumor marker measurement described as the determination of the prostate specific antigen present in a sample.", + "output": "Prostate specific antigen (PSA); total (Prostate specific antigen (PSA))" + }, + { + "input": "Definition: Medical Device described as surgical driver/extractors designed to insert and extract bone plates into or from the surface of bones by applying linear force during orthopedic procedures. These instruments are typically manual, handheld devices with a working end that fits the plate (e.g., by threading to it) and a handle for manipulation. Bone plate driver/extractors are used mainly for temporary insertion of templates in orthopedic procedures (e.g., femur, knee prostheses implantation); dedicated instruments are available for particular plates used in specialized prostheses (e.g., patella templates).", + "output": "Driver/Extractors, Bone Plate (Driver/Extractors)" + }, + { + "input": "Definition: Country described as a country in Central Europe, northwest of Romania.", + "output": "hungary (Southeastern Europe)" + }, + { + "input": "Definition: Finding described as mild memory impairment", + "output": "Grade 1 Memory Impairment, CTCAE (Memory Impairment, CTCAE 5.0)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent operative intervention indicated", + "output": "Grade 4 Typhlitis, CTCAE (Finding)" + }, + { + "input": "Definition: Degenerative Diseases, Central Nervous System described as a disorder that belongs in the group of leukodystrophies. It is caused by mutations in the ASPA gene which is responsible for the production of the enzyme aspartoacylase. It is characterized by spongy degeneration of the white matter of the brain. Signs and symptoms appear in infancy and include mental retardation, loss of motor skills, abnormal muscle tone, feeding difficulties and a very large head.", + "output": "Spongy degeneration of white matter (Degenerative Diseases, Central Nervous System)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the sodium channel epithelial 1 beta subunit (SCNN1B) gene, located at chromosome 16p12.2, which encodes the protein amiloride-sensitive sodium channel subunit beta. Genetic variants at this locus have been associated with bronchiectasis, pseudohypoaldosteronism, and pseudoprimary hyperaldosteronism.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SCNN1B (Medical Device)" + }, + { + "input": "Definition: Spatial Concept described as the greatest possible length of a straight line passing through the center of a circular or spheroid object that connects two points on the circumference.", + "output": "Outer Diameter (Spatial Concept)" + }, + { + "input": "Definition: positive regulation of developmental process described as any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning.", + "output": "positive regulation of cuticle tanning (positive regulation of developmental process)" + }, + { + "input": "Definition: Neoplastic Process described as mucinous cystadenoma of childhood is a benign epithelial ovarian neoplasm with characteristics of a usually unilateral, cystic, unilocular or multilocular lesion with a thin wall or septa and no intracystic solid portion on imaging. It often presents with abdominal pain or an asymptomatic abdominal mass and can be associated with ovarian torsion or malignant transformation.", + "output": "Mucinous cystadenoma of ovary in childhood (Neoplastic Process)" + }, + { + "input": "Definition: something described as a family of bacteriophages containing one genus (Cystovirus) with one member (BACTERIOPHAGE PHI 6).", + "output": "Family Cystoviridae (Virus)" + }, + { + "input": "Definition: CPTAC Responses described as a response that evidence of disease was present after completion of therapy.", + "output": "Evidence of Disease Present after Completion of Therapy (CPTAC Responses)" + }, + { + "input": "Definition: Medical Device described as furniture typically consisting of a platform covered with nonskid (e.g., rubber) material that is mounted on a chromed or stainless steel tubular low structure (e.g., 20 to 30 cm height). Footstools are used for supporting the feet of a seated patient or as an aid for a patient to reach a high surface such as a bed or table.", + "output": "Footstool (Devices)" + }, + { + "input": "Definition: Czech translation of the Medical Subject Headings described as disorders caused by the intentional or unintentional ingestion or exposure to chemical substances such as PHARMACEUTICAL PREPARATIONS; NOXAE; and PESTICIDES.", + "output": "Chemically-Induced Disorder (Polish translation of the Medical Subject Headings)" + }, + { + "input": "Definition: something described as computerized multimedia that contain images, video clips, and sounds in addition to or instead of text, and include highlighted elements that, when selected by the user, instruct the computer program to retrieve one or more of the computerized media.", + "output": "Hypermedium (Intellectual Product)" + }, + { + "input": "Definition: something described as combination package consisting of a gastro-resistant tablet and a rectal suspension.", + "output": "Gastro-Resistant Tablet plus Rectal Suspension Dosage Form (Combined Dosage Form)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.", + "output": "medium-chain-fatty-acid-CoA ligase activity (Molecular Function)" + }, + { + "input": "Definition: Biologic Function described as a process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism.", + "output": "envenomation resulting in negative regulation of calcium channel activity in other organism (Biologic Function)" + }, + { + "input": "Definition: ophthalmic preparation described as the hydrochloride salt form of apraclonidine, a clonidine derivative with selective alpha-2-adrenergic agonistic property. When administered directly to eyes, apraclonidine hydrochloride enhances aqueous humor outflow and decreases aqueous production by vasoconstriction. It is used mostly in ophthalmic preparations for decreasing intraocular pressure.", + "output": "Apraclonidine hydrochloride (A [Preparations])" + }, + { + "input": "Definition: Population Group described as a kind of physical entity describing a group of intended study subjects, which is the primary unit of operational and/or administrative interest in a study.", + "output": "PlannedStudySubject (Population Group)" + }, + { + "input": "Definition: something described as the most dorsal of three subdivisions of the dysgranular insula. Identified by multiple stains, it is found in the human ( Morel-2013 ) and the macaque ( Gallay-2012 ). The others are area Id1 and area Id2.", + "output": "Id3 (Body Location or Region)" + }, + { + "input": "Definition: something described as a question about an individual's ability to put on make-up or shave.", + "output": "Putting on make-up or shaving (Intellectual Product)" + }, + { + "input": "Definition: Osteopathic manipulation, functional method described as an indirect treatment approach that involves finding the dynamic balance point and one of the following: applying an indirect guiding force, holding the position or adding compression to exaggerate position and allow for spontaneous readjustment. The osteopathic practitioner guides the manipulative procedure while the dysfunctional area is being palpated in order to obtain a continuous feedback of the physiologic response to induced motion. The osteopathic practitioner guides the dysfunctional part so as to create a decreasing sense of tissue resistance (increased compliance).", + "output": "Functional Method (Indirect Treatment)" + }, + { + "input": "Definition: Neoplastic Process described as squamous cell carcinoma of the head and neck which is amendable to surgical removal.", + "output": "Resectable Head and Neck Squamous Cell Cancer (Squamous cell carcinoma of the head and neck)" + }, + { + "input": "Definition: something described as stage IIIB includes: T3b, N0/N1, M0. T3b: Primary peritoneal cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis.", + "output": "Stage IIIB Primary Peritoneal Carcinoma AJCC v8 (Stage III Primary Peritoneal Cancer AJCC v8)" + }, + { + "input": "Definition: something described as blood vessels forming villous structures in the third, fourth, and lateral ventricles of the brain.", + "output": "CHOROID PLEXUS (Brain ventricle part)" + }, + { + "input": "Definition: Bone structure of anterior cranial fossa described as the butterfly-shaped bone located at the base of the skull that helps to form the orbit of the eye.", + "output": "Os sphenoidale (Neurocranium)" + }, + { + "input": "Definition: Body part described as the thick curved ridge in the upper area of the ilium.", + "output": "iliac crest (Bone structure of ilium)" + }, + { + "input": "Definition: something described as a measurement of the toxic vacuolation in any of the granulocytic blood cells.", + "output": "Toxic Vacuolation (Histopathology)" + }, + { + "input": "Definition: something described as a morphologic finding indicating the presence of focal or diffuse tumor cell necrosis involving part of the neoplastic cellular infiltrate in a tissue sample. Viable tumor cells are still present.", + "output": "Incomplete Necrosis (Finding)" + }, + { + "input": "Definition: something described as a composite substructure of midbrain tegmentum that includes the magnocellular part of the red nucleus, the dorsal nucleus of the lateral lemniscus, the peripeduncular nucleus and certain nuclei of the midbrain reticular formation including the cuneiform nucleus, the subcuneiform nucleus, the pedunculopontine tegmental nucleus and the linear nucleus of the raphe. It also includes the nucleus intracuneiformis and the parabrachial pigmented nucleus ( Crosby-1962 ).", + "output": "deep tegmental gray (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a type of long, unbranched polysaccharide molecule. Glycosaminoglycans are major structural components of cartilage and are also found in the cornea of the eye.", + "output": "GAG (Connective tissue protein)" + }, + { + "input": "Definition: Benign Neoplasm described as a WHO grade I meningioma characterized by the presence of psammoma bodies that predominate over the meningeal cells.", + "output": "Meningioma, Psammomatous (Benign neoplasm of meninges)" + }, + { + "input": "Definition: something described as a diagnostic spirometer is a device used in pulmonary function testing to measure the volume of gas moving in or out of a patient's lungs.", + "output": "Diagnostic Spirometers (Pulmonary function analyser/analysis system)" + }, + { + "input": "Definition: Tissue described as unbroken cellular lining (intima) of the lymph vessels (e.g., the high endothelial lymphatic venules). It is more permeable than vascular endothelium, lacking selective absorption and functioning mainly to remove plasma proteins that have filtered through the capillaries into the tissue spaces.", + "output": "Endotheliums, Lymphatic (Tissue)" + }, + { + "input": "Definition: something described as the surgical removal of the uterus and surrounding structures, including bilateral pelvic lymph nodes, the parametrium, and the upper one-third to one-half of the vagina.", + "output": "Radical hysterectomy (Excision of adnexa of uterus)" + }, + { + "input": "Definition: Disease or Syndrome described as collapsing glomerulopathy for which no underlying cause has been identified.", + "output": "Primary Collapsing Glomerulopathy (Renal glomerular disease)" + }, + { + "input": "Definition: something described as the hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.", + "output": "proton-transporting ATP synthase, catalytic core (Cell Component)" + }, + { + "input": "Definition: Bone and Bones described as tissue component of lamellar bone, each instance of which is made up of some thin intersecting lamellae, usually internal to some compact bone.", + "output": "Spongy Bones (Skeletal material)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as DNA polymerase delta catalytic subunit (1107 aa, ~124 kDa) is encoded by the human POLD1 gene. This protein is involved in both DNA leading strand synthesis and Okazaki fragment completion.", + "output": "POLD1 (Enzyme)" + }, + { + "input": "Definition: Anaplastic ganglioglioma described as the reemergence of anaplastic ganglioglioma after a period of remission.", + "output": "Recurrent Anaplastic Ganglioglioma (Recurrent Primary Malignant Central Nervous System Neoplasm)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O.", + "output": "2,2',3-trihydroxybiphenyl monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1254\" active clinical trials using this agent.", + "output": "TIAZOFURIN (Pharmacologic Substance)" + }, + { + "input": "Definition: Haemophilus influenzae described as any bacterial organism that can be assigned to the species Haemophilus aegyptius.", + "output": "Haemophilus influenzae, biotype III (Haemophilus influenzae)" + }, + { + "input": "Definition: NSCLC-SAQ Version 1.0 Questionnaire Question described as non-Small Cell Lung Cancer Symptom Assessment Questionnaire v1.0 - How would you rate your coughing at its worst over the last 7 days?", + "output": "NSCLC1-Rate Coughing at Worst (NSCLC-SAQ Version 1.0 Questionnaire Question)" + }, + { + "input": "Definition: Disease or Syndrome described as hypersensitivity in form of an adverse immune reaction against insects. []", + "output": "Insect allergy (Hypersensitivity)" + }, + { + "input": "Definition: Genetic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle.", + "output": "down regulation of transcription during meiosis (negative regulation of transcription, DNA-templated)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Since Last Visit - Have you taken any steps towards making a suicide attempt or preparing to kill yourself (such as collecting pills, getting a gun, giving valuables away or writing a suicide note)?", + "output": "C-SSRS Since Last Visit - Preparatory Acts or Behaviors Toward Suicide Attempt (Intellectual Product)" + }, + { + "input": "Definition: snoRNP binding described as interacting selectively and non-covalently with a box H/ACA snoRNP complex.", + "output": "box H/ACA snoRNP complex binding (Genetic Function)" + }, + { + "input": "Definition: something described as a blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.", + "output": "Systems, I Blood-Group (Body System)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as evaluating and managing a new client in a comprehensive, 60-minute, in-office meeting. This code may be used by providers of services who are able to diagnose.", + "output": "Comprehensive new in-office 60 minutes (New client in-office with ICD diagnosis)" + }, + { + "input": "Definition: something described as stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.", + "output": "photoreceptor disc membrane (Cell Component)" + }, + { + "input": "Definition: Organ or Tissue Function described as the radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem.", + "output": "leaf phyllotactic patterning (phyllotactic patterning)" + }, + { + "input": "Definition: Biologically Active Substance described as RAD50-interacting protein 1 (792 aa, ~91 kDa) is encoded by the human RINT1 gene. This protein plays a role in both telomere maintenance and vesicle transport.", + "output": "Rad50-interacting protein 1, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Unit of acceleration described as an indication of the type of unit of measure being used to express linear acceleration.", + "output": "Unit of Linear Acceleration (Unit of acceleration)" + }, + { + "input": "Definition: ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Naming task for fingers of the dominant hand, middle finger.", + "output": "CDISC ADAS-Cog - Naming Objects and Fingers: Middle (Intellectual Product)" + }, + { + "input": "Definition: Psychotherapy described as method of training to reduce stress and bring the autonomic nervous system under voluntary control.", + "output": "Autogenic technique (psychotherapy using change in consciousness)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Bone Marrow Syndrome, Diamond Blackfan Anemia described as molecular assay reagents intended to identify mutations in genes associated with Diamond-Blackfan anemia, a bone marrow disorder that leads to reduced numbers of red blood cells. Genetic variants at multiple loci have been associated with Diamond-Blackfan anemia. These reagents are intended to detect mutations in multiple Diamond-Blackfan anemia-associated loci simultaneously.", + "output": "Diamond Blackfan Anemia Gene Mutation Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Peptide Fragments described as partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.", + "output": "Fragments, Ig (Peptide Fragments)" + }, + { + "input": "Definition: something described as the area under the urinary excretion rate curve (AURC) from time 0 to the last measurable rate.", + "output": "Area Under Urinary Excretion Rate Curve All (Area Under Urinary Excretion Rate Curve)" + }, + { + "input": "Definition: Sulfonylurea Compounds described as n-4-beta-(2-methoxy-5-chlorobenzamido) -ethylbenzosulfonyl-N'- cyclohexylurea; hypoglycemic used against non-insulin dependent diabetes mellitus; thought to act by increasing insulin receptor expression in target tissues.", + "output": "Glyburide-containing product (Second generation sulfonylurea)" + }, + { + "input": "Definition: Occupational Activity described as services, systems and policies for the provision of mass communication through radio, television, newspapers and internet.", + "output": "Media services, systems and policies (CHAPTER 5 SERVICES, SYSTEMS AND POLICIES)" + }, + { + "input": "Definition: Cardiovascular route described as injection of a medicinal product into an artery.", + "output": "Intraarterial use (RouteBySite)" + }, + { + "input": "Definition: Abnormal brain FDG positron emission tomography described as reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan.", + "output": "Hypothalamic hypometabolism in FDG PET (Abnormal brain FDG positron emission tomography)" + }, + { + "input": "Definition: chemokine receptor binding described as interacting selectively and non-covalently with a chemokine receptor in the CXCR family.", + "output": "CXCR chemokine receptor binding (Molecular Function)" + }, + { + "input": "Definition: Drug allergens described as magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.", + "output": "MAGNESIUM (Magnesium Compounds)" + }, + { + "input": "Definition: Probe, sound, bougie AND/OR airway described as a device used to stretch or enlarge an opening.", + "output": "Dilator (PROBES, SOUNDS, BOUGIES AND AIRWAYS)" + }, + { + "input": "Definition: Intellectual Product described as a set of image generation parameter values necessary to create a single set of images from a single MR scan. EXAMPLE(S): OTHER NAME(S): NOTE(S): Given that this sub-subclass of ImagingProcessProtocolElement actually names the process as Reconstruction and includes that word in the name of the class, the word Process is omitted from the class name.", + "output": "Magnetic Resonance Imaging Reconstruction Protocol Element (Protocol Element)" + }, + { + "input": "Definition: nervous system process described as any process pertaining to the functions of the nervous and muscular systems of an organism.", + "output": "neuromuscular process (Organism Function)" + }, + { + "input": "Definition: something described as a methylxanthine and derivative of theophylline. Proxyphylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Proxyphylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.", + "output": "1,3-Dimethyl-7-(2-hydroxypropyl)xanthine (Pharmacologic Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable inhibitor of both the serine/threonine kinase P21-activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD)-synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT; NAMPRTase), with potential antineoplastic activity. Upon administration, KPT-9274 allosterically binds to, destabilizes and causes degradation of PAK4. This inhibits PAK4-mediated signaling, induces cell death in, and inhibits the proliferation of PAK4-overexpressing tumor cells. In addition, KPT-9274 binds to and inhibits the activity of NAMPT. This depletes cellular NAD and inhibits NAD-dependent enzymes, both of which are needed for rapid cell proliferation; this results in tumor cell death in NAMPT-overexpressing cancer cells. PAK4, a serine/threonine kinase and member of the PAK family of proteins upregulated in various cancer cell types, regulates cell motility, proliferation and survival. NAMPT, an enzyme that is responsible for maintaining the intracellular NAD pool, plays a key role in the regulation of cellular metabolism and has cytokine-like activities. NAMPT is often overexpressed in a variety of cancers and metabolic disorders and tumor cells rely on NAMPT activity for their NAD supply. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C126646\" active clinical trials using this agent.", + "output": "KPT-9274 (Pharmacologic Substance)" + }, + { + "input": "Definition: NCI-Designated Comprehensive Cancer Center described as the goal of the Barbara Ann Karmanos Cancer Institute is the ultimate prevention and cure of cancer. The Center's programs are directed to the prevention, early detection, or treatment of neoplasia and are based on the KCI's laboratory, clinical, and population research. A primary objective is to integrate scientific research and clinical programs with community outreach activities to local populations in Detroit. Research is conducted through more than 300 clinical trials at the Center, including a Phase I trial program. It has a partnership with Wayne State University School of Medicine and received NCI designation in 1978.", + "output": "Barbara Ann Karmano Cancer Institute (Health Care Related Organization)" + }, + { + "input": "Definition: Intellectual Product described as data submitted to an abbreviated new animal drug application.", + "output": "Abbreviated New Animal Drug Application (Application)" + }, + { + "input": "Definition: Central Nervous System described as class of psychoses with disturbance mainly of cognition (content and form of thought, perception, sense of self versus external world, volition) and psychomotor function, rather than affect.", + "output": "Dementia praecox (Central Nervous System)" + }, + { + "input": "Definition: Clostridiales described as a genus of anaerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Ruminococcaceae.", + "output": "Genus Faecalibacterium (Clostridiales)" + }, + { + "input": "Definition: Mutation described as mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.", + "output": "Insertional Mutagenesis (Mutation)" + }, + { + "input": "Definition: something described as a lymph node located along the internal iliac artery.", + "output": "Hypogastric node (Common iliac lymph node)" + }, + { + "input": "Definition: Research Device described as small solid plates (e.g., glass, silicon, nylon) on which densely packed samples (up to one million or more spots per microarray) of known sequences of nucleic acid nucleotides (e.g., DNA fragments known as oligonucleotides) in a predetermined array are either synthesized using photolithographic procedures or deposited using pin-spotting procedures (e.g., with ink-jet printers). Typically, the microarray is washed with a labeled (e.g., fluorescent) sample of an unknown sequence. The immobilized microarray spots mate with the sample sequences according to their complementary nature. The resulting fluorescence pattern permits the identification of the sample sequence using an appropriate reader (scanner) and/or data processing using a molecular array analyzer. Dedicated molecular microarrays are used for genetic expression, to detect variations in gene copies, and to detect gene mutations/polymorphisms.", + "output": "Molecular Microarray Spots (In Vitro Diagnostics and Laboratory Equipment)" + }, + { + "input": "Definition: something described as a class of substances that binds to and activates a receptor and is intended to induce the maximum biological response.", + "output": "FULL RECEPTOR AGONIST (Agonist)" + }, + { + "input": "Definition: Diagnostic, Therapeutic, and Research Equipment described as physiologic measuring instruments designed to detect, quantify, and give a real-time analysis of breathing sounds captured during a short span of time (e.g., 30 seconds). These instruments also measure the proportion of the respiratory cycle occupied by continuous high-pitched whistling noises (i.e., wheezing). These instruments typically consist of a handheld unit with on/off controls; an electronic processor with dedicated software; a display; and a detachable probe that includes a sound sensor which is placed on the patient's neck. Breathing sounds measuring instruments are used in healthcare facilities, in the field, and at home for a quick evaluation of the patient's status and to detect the presence of wheezing after drug (e.g., bronchodilator) administration.", + "output": "Breath Sounds Measuring Instruments (Measuring Instruments)" + }, + { + "input": "Definition: Bone Diseases, Developmental described as a congenital abnormality in which the meninges protrude through a defect in the cranium.", + "output": "Cranial Meningocele (Congenital anomaly of skull)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as a congenital cortical development anomaly due to abnormal neuronal migration involving neocortical and hippocampal lamination, corpus callosum, cerebellum and brainstem. A large clinical spectrum can be observed, from children with severe epilepsy and intellectual and motor deficit to cases with severe cerebral dysgenesis in the antenatal period leading to pregnancy termination due to the severity of the prognosis.", + "output": "Lissencephaly due to TUBA1A (tubulin alpha 1A) mutation (Lissencephaly)" + }, + { + "input": "Definition: Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 - I am able to enjoy life.", + "output": "FAC050-I Am Able to Enjoy Life (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 63 above, was your activity limited by: General health?", + "output": "PODCI365 (PODCI Adolescent Self-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Enzyme described as peptidyl-prolyl cis-trans isomerase D (370 aa, ~41 kDa) is encoded by the human PPID gene. This protein plays a role in the isomerization of imidic peptide bonds.", + "output": "Cyp40 protein, human (Enzyme)" + }, + { + "input": "Definition: something described as infiltration of numerous eosinophils (usually greater than 15 per high power field) into the squamous epithelium of the esophagus, and layering of eosinophils on the surface layer of the esophagus.", + "output": "Eosinophilic infiltration of the oesophagus (Eosinophilic gastroenteritis)" + }, + { + "input": "Definition: Daily or Recreational Activity described as repose after exertion.", + "output": "Rests (Energy Maintenance)" + }, + { + "input": "Definition: Emetogenic Therapy Adjuncts described as the hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.", + "output": "Dihydrate, Ondansetron Monohydrochloride (Emetogenic Therapy Adjuncts)" + }, + { + "input": "Definition: Glycine subgen. Soja described as food plant which contains little starch and is rich in protein; used to prepare protein supplements; also furnishes commercially important enzymes and other products.", + "output": "Glycine max (L.) Merr. (Glycine subgen. Soja)" + }, + { + "input": "Definition: something described as inability to evacuate bowels properly, characterized by difficulty passing motions and a sensation of blockage or incomplete emptying.", + "output": "Obstructive defecation syndrome (Functional disorder of intestine)" + }, + { + "input": "Definition: Cell Function described as the disassembly of a bipolar filament composed of myosin II molecules.", + "output": "myosin II filament disassembly (myosin II filament organization)" + }, + { + "input": "Definition: something described as human TPI1 wild-type allele is located in the vicinity of 12p13.31 and is approximately 4 kb in length. This allele, which encodes triosephosphate isomerase protein, is involved in the isomerization of both glyceraldehyde 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in both glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency.", + "output": "TIM (TPI1 gene)" + }, + { + "input": "Definition: Action described as freedom from activity.", + "output": "resting (body physical activity)" + }, + { + "input": "Definition: something described as a form-genus of spherical to rod-shaped CYANOBACTERIA in the order Chroococcales. They contain THYLAKOIDS and are found in a wide range of habitats.", + "output": "Anacystis (Bacterium)" + }, + { + "input": "Definition: Shield described as shields designed to block or attenuate the radiation beam during radiotherapy procedures (also known as radiotherapy block shields or shielding blocks). These shields may consist of pre-shaped lead blocks or custom-made devices created using a low-melting-point alloy (i.e., one that melts at less than 100 degrees Celsius [212 degrees Fahrenheit]) in the casting procedure. These low-melting-point alloys are also known as Cerrobend and Lipowitz's alloys. Radiotherapy block shields have a shape that permits the performance of the radiotherapy procedure on the target tissues while shielding unwanted radiation in order to avoid damage to healthy tissues. They are used in radiotherapy areas in healthcare facilities. Other alloys (e.g., tungsten based) are also used to make radiotherapy block shields.", + "output": "Shields, Radiotherapy Block (Shield)" + }, + { + "input": "Definition: something described as moderate pain; limiting instrumental ADL", + "output": "Grade 2 Gastrointestinal Pain, CTCAE (Finding)" + }, + { + "input": "Definition: Health Care Activity described as developing and/or revising a patient's care plan while remaining consistent with his or her religious beliefs. Service is billed in 15-minute increments.", + "output": "sprtlnrse care plan devment/ (Spiritual nursing care)" + }, + { + "input": "Definition: Finding related to pregnancy described as describes the pregnancy state of a referenced subject.", + "output": "PREGSTAT (Finding)" + }, + { + "input": "Definition: R [Preparations] described as a drug used to treat a nerve disease called amyotrophic lateral sclerosis (ALS). It is also being studied in the treatment of melanoma (a type of skin cancer). Riluzole blocks the release of a substance that melanoma cells need to grow. It is a type of glutamate release inhibitor.", + "output": "2 Amino 6 trifluoromethoxybenzothiazole (Thiazoles)" + }, + { + "input": "Definition: something described as steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.", + "output": "cholestene (Organic Chemical)" + }, + { + "input": "Definition: something described as one of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.", + "output": "INSULIN LIKE GROWTH FACTOR 05 BINDING PROTEIN (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Spinal Cord Compression, CTCAE described as severe symptoms; limiting self care ADL", + "output": "Grade 3 Spinal Cord Compression, CTCAE (Spinal Cord Compression, CTCAE)" + }, + { + "input": "Definition: Abnormality of the posterior pituitary described as a lack of antidiuretic hormone that causes excessive production of very dilute urine", + "output": "Neurohypophyseal diabetes insipidus (Hypopituitarism)" + }, + { + "input": "Definition: Registered nurse described as (1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, provides preoperative, intraoperative, and postoperative care to patients and assists in management and resuscitation of critical patients in intensive care, coronary care, and emergency situations. Nurse anesthetists are certified following successful completion of credentials and state licensure review and a national examination directed by the Council on Certification of Nurse Anesthetists. (2) A registered nurse who is qualified by special training to administer anesthesia in collaboration with a physician or dentist and who can assist in the care of patients who are in critical condition.", + "output": "crna (Anesthetist)" + }, + { + "input": "Definition: something described as the protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.", + "output": "Ventral hernia without mention of obstruction or gangrene (Other hernia of abdominal cavity without mention of obstruction or gangrene)" + }, + { + "input": "Definition: something described as moderate symptoms; limiting instrumental ADL", + "output": "Grade 2 Olfactory nerve disorder (Olfactory Nerve Disorder, CTCAE)" + }, + { + "input": "Definition: Escape of urine from bladder described as an abnormal communication between the urinary bladder and another organ or anatomic site.", + "output": "vesical fistulas (Anatomical Abnormality)" + }, + { + "input": "Definition: Medical Device described as tourniquets designed to circumferentially constrict/compress an extremity for a limited period of time to control venous and arterial blood flow with a non-inflatable strap. These tourniquets usually consist of a plain (e.g., rubber, fabric) elastic band that may include some means (e.g., clips) for fixing around the limb. Strap non-inflatable tourniquets are used mainly for phlebotomy and/or intravenous infusion procedures; dedicated tourniquets are also available for use in emergency situations to control hemorrhage.", + "output": "Tourniquets, Non-Inflatable Strap (Medical Device)" + }, + { + "input": "Definition: something described as a finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).", + "output": "Kidney Anastomotic Leak (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: Synapses described as a synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.", + "output": "Schaffer collateral - CA1 synapse (Synapses)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in phospholipid metabolism.", + "output": "PPLA2 (Gene or Genome)" + }, + { + "input": "Definition: Monitors, Physiologic, Respiration described as monitors designed to simultaneously and continuously sample, measure, and display the concentrations of several anesthetic gases, such as nitrogen oxide (N2O), and halogenated agents (e.g., halothane, enflurane, and isoflurane) administered to a patient during surgical procedures using general anesthesia. Some monitors are also capable of determining the concentrations of the anesthetic gases using the principle that different gases absorb infrared light (IR) at different wavelengths (IR spectrometry). Other monitors use the change of resonant frequency in a quartz crystal as its mass increases when a special coating absorbs the anesthetic agent. Still other monitors combine different techniques to perform the measurements. Anesthetic gas monitors are used during anesthetic administration to ensure that appropriate levels of these agents are administered to patients.", + "output": "Monitors, Bedside, Anesthetic Gas (Medical Device)" + }, + { + "input": "Definition: Spatial Concept described as physical location of BRS3_Gene", + "output": "X: 135295645-135300118 (Spatial Concept)" + }, + { + "input": "Definition: Physical Examination described as baker's cyst: Popliteal cysts resulting from a synovial effusion of the knee. A communication exists between the knee joint and the semimembranosus-gastrocnemial bursa beneath the medial head of the gastrocnemius muscle. These cysts may rupture and result in pain, swelling and erythema of the calf (pseudothrombophlebitis).", + "output": "Swelling behind knee (Baker's cyst) present (Finding)" + }, + { + "input": "Definition: Capnocytophaga described as a gram-negative gliding bacterium isolated from the oral cavity. It is a pathogen often causing PERIODONTITIS.", + "output": "Sphaerocytophaga (Bacterium)" + }, + { + "input": "Definition: alkaloid catabolic process described as the chemical reactions and pathways resulting in the breakdown of ajmaline.", + "output": "ajmaline breakdown (organic hydroxy compound catabolic process)" + }, + { + "input": "Definition: something described as an independent variable manipulated by the experimentalist with the intention to affect biological systems in a way that can be measured by an assay. EXAMPLE(S): genotype, time as a factor in time series studies, dose a factor in dose response studies, compound as a factor in compound treatment studies, or disease state in disease studies OTHER NAME(S): NOTE(S):", + "output": "Experimental Factor (Factor)" + }, + { + "input": "Definition: Intellectual Product described as a table of data specifically regarding systemic chemotherapy.", + "output": "Systemic Chemotherapy Table (Intellectual Product)" + }, + { + "input": "Definition: Delivery of Health Care described as interactions between health personnel and patients.", + "output": "Professional Patient Relationship (Interpersonal Relations)" + }, + { + "input": "Definition: something described as the presence of a fistula between the perineum and the rectum.", + "output": "Rectoperineal fistula (gastrointestinal)" + }, + { + "input": "Definition: Common nursing interventions described as assessing a patient's mental health and/or emotional wellbeing.", + "output": "assessment mental health (Health Care Activity)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Interviewer - In the past 30 days: How much of a problem did your family have because of your health problems?", + "output": "WHODAS 2.0 36-item Version Interviewer-administered - How Much Problem Did Your Family Have (Intellectual Product)" + }, + { + "input": "Definition: Qualitative Concept described as of or relating to a septum.", + "output": "Septate (Qualitative Concept)" + }, + { + "input": "Definition: something described as the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) How would you rate each of the following during the last 4 weeks? Your ability to reach orgasm (climax)?", + "output": "EPIC1-Rate Ability to Reach Orgasm (Intellectual Product)" + }, + { + "input": "Definition: Tracheophyta described as buttercup, crowfoot.", + "output": "crowfoot (Ranunculus)" + }, + { + "input": "Definition: Unit of mass described as the non-SI unit of mass equal to 0.3732417216 kg.There are 12 apothecaries ounces, or 240 pennyweight, or 5760 grains in the Troy pound.", + "output": "pound (Unit of mass)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as a substance that is used in cancer research to cause tumors in laboratory animals. This is done to test new diets, drugs, and procedures for use in cancer prevention and treatment.", + "output": "4 nitroquinoline N oxide (Nitroquinolines)" + }, + { + "input": "Definition: Pregnancy Outcome described as an infant delivered, that breathes/shows any evidence of life (e.g. beating heart, pulsation of umbilical cord) or definite movement of voluntary muscles.", + "output": "Live Birth (Pregnancy Outcome)" + }, + { + "input": "Definition: something described as a biomarker identifying T-cells in normal lymphoid tissues and in lymphoproliferative disorders.", + "output": "T-Cell Marker (Biological Markers)" + }, + { + "input": "Definition: something described as a cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.", + "output": "oxidative stress-induced premature senescence (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk & Resilience Inventory-2 - During deployment: I had problems getting in touch with a family member or other loved one.", + "output": "DRRI1M01 (Intellectual Product)" + }, + { + "input": "Definition: Social Problems described as the fraudulent misrepresentation of the diagnosis and treatment of disease.", + "output": "Quackeries (Social Problems)" + }, + { + "input": "Definition: Centrosome described as self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.", + "output": "Centriole structure (Centrioles)" + }, + { + "input": "Definition: Finding described as the pressure within the left ventricle of the heart at the end of the period when the chambers of the heart refill with blood and just before the contraction begins.", + "output": "Lt ventric end-diast pressure (Left ventricular pressure)" + }, + { + "input": "Definition: something described as extent of positive perception of nursing care to relieve pain", + "output": "Client Satisfaction: Pain Management (Satisfaction with Care)" + }, + { + "input": "Definition: Planned Start of Assessment Interval described as the period of time that the cardiovascular system findings assessment, done over an interval of time, is intended to begin.", + "output": "CVSTINT (Temporal Concept)" + }, + { + "input": "Definition: General Qualifier described as made for or directed or adjusted to a particular individual.", + "output": "Personalized (Qualitative Concept)" + }, + { + "input": "Definition: something described as a question about whether an individual did any heavy work around the house.", + "output": "Do Heavy household Chores (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Secretory Granule described as granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.", + "output": "secondary granule (Secretory Granule)" + }, + { + "input": "Definition: Malignant tumor of orbit described as a melanoma that arises from the structures of the orbit.", + "output": "Orbital Melanoma (Neoplastic Process)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as material inserted into a prepared tooth cavity, or the process of inserting, condensing, shaping and finishing this material in a prepared tooth cavity or root canal.", + "output": "Dental procedure;filling (Restoration of tooth)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite described as molecular assay reagents intended to identify Amoeboid protozoa, a genus of hematozoan protozoa, by detecting specific nucleic acid information of the target parasite. Some species of these parasites may cause amebiasis (typically in the intestines, but potentially extending to the liver and lungs); they are transmitted to humans through water or cysts in contaminated food.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Amoeboid Protozoa (Medical Device)" + }, + { + "input": "Definition: Magnetic Resonance Imaging described as a type of MAGNETIC RESONANCE IMAGING that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.", + "output": "ECHO PLANAR MRI (Diagnostic Procedure)" + }, + { + "input": "Definition: Health Care Activity described as actions performed to control problems pertaining to the kidney", + "output": "rnax perform renal care (Health Care Activity)" + }, + { + "input": "Definition: Male population group described as an inability to have an erection of the penis adequate for sexual intercourse.", + "output": "Difficulty getting an erection (Erectile dysfunction)" + }, + { + "input": "Definition: Disease or Syndrome described as a type of focal myoclonic seizure during which awareness is fully retained throughout.", + "output": "Focal aware myoclonic seizure (Focal motor aware seizure)" + }, + { + "input": "Definition: Finding described as hairline fracture; mild pain; limiting instrumental ADL; non-operative intervention indicated", + "output": "Grade 2 Hip Fracture, CTCAE (Finding)" + }, + { + "input": "Definition: Cell described as a secretory cell that discharges its product without loss of cytoplasm.", + "output": "Eccrine Cell (Epithelial Cells)" + }, + { + "input": "Definition: something described as cartridge dental syringes designed to introduce impression and/or filling materials under high pressure during dental procedures. Dental impression/filling syringes are used either in permanent teeth and in retrograde root-canal filling procedures and/or to obtain a negative copy (i.e., impression) of dental or related structures (e.g., dental arch), typically for construction or assembly of a fixed restoration or denture.", + "output": "Impression/Filling Material Dental Syringes (Medical Device)" + }, + { + "input": "Definition: Household appliance described as sinks designed for cleaning food preparation and delivery utensils and/or washing dishes. These sinks typically consist of one or more large, deep stainless steel bowls with a seamless construction without crevices; several faucets; a cold and hot water supply; and appropriate tubing for drainage. Kitchen sinks are used in central food preparation and nourishment stations of healthcare facilities.", + "output": "Sinks, Kitchen (Household appliance)" + }, + { + "input": "Definition: Logical Condition described as a fact that must always be true just after the execution of some section of code.", + "output": "Post-condition (Conceptual Entity)" + }, + { + "input": "Definition: something described as semi-solid preparation consisting of a gel intended to be placed in the pouch between the tooth and the gingiva.", + "output": "Periodontal Gel Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Antidiabetics described as any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).", + "output": "GLP-1 Mimetics (Antidiabetics)" + }, + { + "input": "Definition: something described as the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion.", + "output": "signal transduction involved in positive regulation of conjugation with cellular fusion (positive regulation of conjugation with cellular fusion)" + }, + { + "input": "Definition: Brassicaceae described as weed used in studies of root growth pattern changes and molecular genetics of higher plants; in Family Brassicaceae.", + "output": "Cardaminopsis Hayek (Plant)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) AIDS or DEVICES that you usually use for any of these activities - Devices used for dressing (button hook, zipper pull, long-handled shoe horn, etc.).", + "output": "HAQ01-Aid: Devices Used for Dressing (HAQ-DI Questionnaire Question)" + }, + { + "input": "Definition: regulation of cellular component size described as intracellular or extracellular processes that control, manage, or govern adoption, production, or maintenance of sustained or transient changes in cell size.", + "output": "regulation of cell size (Cell Growth Processes)" + }, + { + "input": "Definition: something described as deletion of the short arm of chromosome 10 with retarded psychomotor development and variable abnormalities, including dwarfism, craniofacial dysmorphism (downslanting palpebral fissures, anteverted nostrils, and eye and ear anomalies), deformed hands and feet, cryptorchidism, and dysplasia of the olfactory system.", + "output": "chromosome 10p deletion syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: cation channel complex described as an assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.", + "output": "NMDA selective glutamate receptor complex (ionotropic glutamate receptor complex)" + }, + { + "input": "Definition: MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of medulloblastoma.", + "output": "MIRN326 (MicroRNA Gene)" + }, + { + "input": "Definition: Teaching how to perform activity described as assisting in the establishment and maintenance of successful breastfeeding", + "output": "Instructn relating breast-feed (Lactation management)" + }, + { + "input": "Definition: MMSE Functional Test Question described as mini-Mental State Examination - Now I am going to ask you to repeat what I say. Ready? \"No ifs, ands, or buts.\" Now you say that.", + "output": "MMS1-Repeat What I Say (MMSE Functional Test Question)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of folinic acid (leucovorin), 5-fluorouracil, and liposomal irinotecan that may be used in the treatment of adenocarcinoma of the pancreas.", + "output": "Folinic Acid/Fluorouracil/Liposomal Irinotecan (Regimen Used to Treat Pancreatic Carcinoma)" + }, + { + "input": "Definition: something described as a measurement of the endomysial IgA antibody in a biological specimen.", + "output": "EDMIGAAB (Laboratory Procedure)" + }, + { + "input": "Definition: something described as agents used to occlude dental enamel pits and fissures in the prevention of dental caries.", + "output": "Fissure Sealants, Pit (Biomedical or Dental Material)" + }, + { + "input": "Definition: Abnormal circulating metabolite concentration described as any deviation from the normal concentration of a nitrogen compound in the blood circulation.", + "output": "Abnormal circulating nitrogen compound concentration (Finding)" + }, + { + "input": "Definition: Professional or Occupational Group described as workers who use wood, veneers, and laminates to manufacture a variety of products such as cabinets and furniture.", + "output": "Woodworkers (Miscellaneous Occupation)" + }, + { + "input": "Definition: outer mitochondrial membrane protein complex described as a large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.", + "output": "mitochondrial sorting and assembly machinery complex (Cell Component)" + }, + { + "input": "Definition: Intellectual Product described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale - Grip: Are you able to open car doors?", + "output": "HAQ0228 (Intellectual Product)" + }, + { + "input": "Definition: SF36 v2 0 Standard Questionnaire Question described as the Short Form 36 Health Survey Standard, US Version 2.0 (SF36 v2.0 Standard) Question 3d.", + "output": "SF-36 v2.0 Standard - Question 3d (Intellectual Product)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was unable to walk alone, even with walking equipment, but was able to walk short distances with the help of another person and required a wheelchair to get around the neighborhood.", + "output": "Unable to walk alone, even with walking equipment. Able to walk short distances with the help of another person, and required a wheelchair to get around the neighborhood (Finding)" + }, + { + "input": "Definition: MIR429 gene described as the human MIR429 wild-type allele is located in the vicinity of 1p36.33 and is approximately 82 bases in length. This allele, which encodes MIR429 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with development of breast cancer.", + "output": "MicroRNA 429 wt Allele (MIR429 gene)" + }, + { + "input": "Definition: something described as a region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.", + "output": "chromocenter (Region of chromosome)" + }, + { + "input": "Definition: Precursor B-cell lymphoblastic leukemia described as b acute lymphoblastic leukemia with translocations involving tyrosine kinases, or translocations involving either the cytokine receptor-like factor 2 (CRLF2) or rearrangements leading to truncation and activation of the erythropoietin receptor (EPOR). It is associated with an adverse prognosis.", + "output": "B-ALL with Translocations Involving Tyrosine Kinases or Cytokine Receptors (B-lymphoblastic leukemia lymphoma BCR-ABL1-like)" + }, + { + "input": "Definition: Receptor described as a TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.", + "output": "Receptor, TIE-1 (Receptors, TIE)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of vulvar cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.", + "output": "Vulvar Cancer Clinical Distant Metastasis TNM Finding v7 (Vulvar Cancer Clinical TNM Finding v7)" + }, + { + "input": "Definition: Nasal dosage form described as a medication delivered as a mist to be inhaled through the nose as a measured dose", + "output": "Nasal Inhaler Dosage Form (Medical Device)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure of a quantity of substance per unit mass, expressed as the quantity of substance in International Units, divided by the mass of the substance in kilograms. It is also used as a dose calculation unit expressed in International Units of biological activity per one kilogram of body mass.", + "output": "/kg (Unit of Arbitrary Substance Concentration)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as guanylate cyclase soluble subunit alpha-1 (690 aa, ~77 kDa) is encoded by the human GUCY1A1 gene. This protein is involved in the biosynthesis of cGMP.", + "output": "NOGC, Alpha-1 Subunit (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as phenylalanine-tRNA ligase beta subunit (589 aa, ~66 kDa) is encoded by the human FARSB gene. This protein plays a role in attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA.", + "output": "Phenylalanyl-tRNA Ligase Beta Subunit (Biologically Active Substance)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the Clinical Opiate Withdrawal Scale (COWS) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).", + "output": "QS-COWS TEST (Intellectual Product)" + }, + { + "input": "Definition: lipoprotein particle binding described as interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.", + "output": "VLDL binding (lipoprotein particle binding)" + }, + { + "input": "Definition: Coal described as a natural fuel formed by partial decomposition of vegetable matter under certain environmental conditions.", + "output": "Coal product, NOS (Coal AND/OR petroleum product)" + }, + { + "input": "Definition: Anatomical Abnormality described as abnormal shape of one or more phalanges of the thumb such that affected phalanges resemble a triangle.", + "output": "Triangular shaped thumb phalanx (Anatomical Abnormality)" + }, + { + "input": "Definition: Mammal described as the Beagle is a hardy, sturdy squarely-built, small hound, with a short coat in tri-color, red and white, orange and white, or lemon and white. The ears are long, wide, and pendant. The average height range is 13-16 inches and the average weight range is 20-25 pounds.", + "output": "Beagle (Canis familiaris)" + }, + { + "input": "Definition: something described as olation of molecule generally by way of suspending the molecule in its mother liquor followed by super saturation.", + "output": "Purification, Crystallization (Laboratory Procedure)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 test name.", + "output": "QS-NCCN-FACT FBRSI-24 Version 2 TEST (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Pulmonary function tests described as the total volume of air in the lungs after maximum inhalation as a proportion of the predicted normal value.", + "output": "TLCPP (Pulmonary function tests)" + }, + { + "input": "Definition: hydro-lyase activity described as catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O.", + "output": "3-hydroxypropionyl-CoA dehydratase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a class of BRYOPHYTA .", + "output": "Andreaeopsida J.H.Schaffn., 1909 (Plant)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as agent that promotes the urinary excretion of uric acid.", + "output": "Probenecid-containing product (Electrolyte and renal drugs)" + }, + { + "input": "Definition: Quantitative Concept described as a stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.", + "output": "Markov Chain (Stochastic Modeling)" + }, + { + "input": "Definition: Vitamins described as a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries. Found in citrus and other fruits, and in vegetables, vitamin C cannot be produced or stored by humans and must be obtained in the diet. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C285\" active clinical trials using this agent.", + "output": "\u00e1cido asc\u00f3rbico (Organic Chemical)" + }, + { + "input": "Definition: Biologically Active Substance described as ligands of the TIE2 receptor involved in angiogenesis.", + "output": "Angiopoietins (Growth Factor)" + }, + { + "input": "Definition: Vaginal Pain, CTCAE 5.0 described as mild pain", + "output": "Grade 1 Vaginal pain (Vaginal Pain, CTCAE 5.0)" + }, + { + "input": "Definition: Male urogenital diaphragm described as lobular organ the parenchyma of which consists of glandular acini which communicate the bulbar part of the urethra. Examples: There only two instances, right and left bulbo-urethral glands.", + "output": "GLAND, BULBOURETHRAL (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Pharmacologic Substance described as a drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.", + "output": "2-(1-HEXYLOXYETHYL)-2-DEVINYLPYROPHEOPHORBIDE A (Photosensitizing Agents)" + }, + { + "input": "Definition: WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered (WHODAS 2.0 12+24-item Version Interviewer-administered) Which describes your main work status best?", + "output": "WHODAS 2.0 12+24-item Version Interviewer-administered - Describes Main Work Status Best (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify hepatitis A virus, a member of the family Picornaviridae, by detecting the nucleic acid of the target virus. Hepatitis A virus may cause hepatitis, a disease characterized by jaundice and the increase of some enzymes in serum (e.g., aspartate aminotransferase); these viruses are almost exclusively transmitted by the fecal-oral route or via contaminated food or water, although parenteral transmission is possible.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Hepatitis A (Medical Device)" + }, + { + "input": "Definition: something described as carotenoid which is a terpene assembled from 8 isoprene units.", + "output": "2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene (L [Preparations])" + }, + { + "input": "Definition: something described as an internist who concentrates on disorders of the internal (endocrine) glands such as the thyroid and adrenal glands. This specialist also deals with disorders such as diabetes, metabolic and nutritional disorders, obesity, pituitary diseases and menstrual and sexual problems.", + "output": "Physicians; Physician/Osteopath; Endocrinology, Diabetes & Metabolism (Professional or Occupational Group)" + }, + { + "input": "Definition: Childhood Acute Myeloid Leukemia Not Otherwise Specified described as an acute megakaryoblastic leukemia occurring in children.", + "output": "Childhood Acute Megakaryocytic Leukemia (Neoplastic Process)" + }, + { + "input": "Definition: Cell Function described as a process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling.", + "output": "G2/M transition DNA damage checkpoint effector process (Cell Function)" + }, + { + "input": "Definition: Type of drug described as agents which reduce or control high cholesterol and bring about lower cholesterol levels in both the blood and the liver.", + "output": "INHIB CHOLESTEROL (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as the Short Form 36 Health Survey Acute, Version 1.0 (SF36 v1.0 Acute) Question 8.", + "output": "SF-36 v1.0 Acute - Question 8 (SF36 v1 0 Acute Questionnaire Question)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated", + "output": "Grade 4 Bronchial Fistula, CTCAE (Bronchial Fistula, CTCAE)" + }, + { + "input": "Definition: Transcription factor genes described as this gene plays a regulatory role in cell cycle progression.", + "output": "v-MYB Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Actinobacteria phylum described as a family of bacteria including numerous parasitic and pathogenic forms.", + "output": "Actinomycetaceae Buchanan 1918 (Approved Lists 1980) emend. Nouioui et al. 2018 (Actinobacteria class)" + }, + { + "input": "Definition: something described as a question about whether an individual worries or worried that the transplant will not work.", + "output": "I worry that the transplant will not work (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome characterized by early-childhood onset of cerebellar ataxia associated with generalized tonic-clonic epilepsy and psychomotor development delay, dysarthria, gaze-evoked nystagmus and learning disability. Other features in some patients include upper motor neuron signs with leg spasticity and extensor plantar responses, and mild cerebellar atrophy on brain MRI. Caused by homozygous mutation in the WWOX gene on chromosome 16q23.", + "output": "Autosomal recessive cerebellar ataxia, epilepsy, intellectual disability syndrome due to WWOX deficiency (Hereditary disorder of the visual system)" + }, + { + "input": "Definition: Other excision procedures on abdomen, peritoneum or omentum described as surgery to remove the lower part of the bowel, rectum, uterus, cervix, ovaries, fallopian tubes, and vagina. Pelvic lymph nodes may also be removed.", + "output": "Posterior pelvic exenteration (Other excision procedures on abdomen, peritoneum or omentum)" + }, + { + "input": "Definition: Carts, Storage/Transport described as carts designed for storage and local transportation of physiologic monitors, accessories, and products needed for patient monitoring inside a particular area of a healthcare facility. These carts typically consist of an open or enclosed structure made of metal, plastic, or a combination of these materials and may include drawers and shelves. The structure is mounted on wheels that are usually an integral part of the cart. Physiologic monitor carts are used in intensive care units, emergency rooms, patient rooms, and doctors' offices for temporary assessment or to evaluate particular physiologic parameters.", + "output": "Carts, Storage/Transport, Physiologic Monitor (Medical Device)" + }, + { + "input": "Definition: Conceptual Entity described as a therapeutically active agent, treatment regimen or procedure that is intended to provide baseline measurements for the experimental protocol of a clinical trial.", + "output": "Active Comparator (Conceptual Entity)" + }, + { + "input": "Definition: something described as an invasive adenocarcinoma of the breast usually affecting post-menopausal women, characterized by extensive spindle cell metaplasia of the neoplastic glandular cells.", + "output": "breast adenocarcinoma with spindle cell metaplasia (Adenocarcinoma with spindle cell metaplasia)" + }, + { + "input": "Definition: Organophosphates described as the organophosphorus agent tetrachlorvinphos.", + "output": "TCVP (Organophosphates)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an amino acid derivative used to counteract high blood pressure caused by interleukin-2.", + "output": "L NG Monomethyl Arginine (Nitric Oxide Synthase Inhibitor)" + }, + { + "input": "Definition: Pigmentation Disorders described as excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.", + "output": "HYPERPIGMENTATION (Pigmentation Disorders)" + }, + { + "input": "Definition: Disease or Syndrome described as an allergy to Penicillin.", + "output": "allergies penicillin (Drug-related disorder)" + }, + { + "input": "Definition: something described as a suction lipoplasty system is a device intended for aesthetic body contouring. The device consists of a powered suction pump (containing a microbial filter on the exhaust and a microbial in-line filter in the connecting tubing between the collection bottle and the safety trap), collection bottle, cannula, and connecting tube. The microbial filters, tubing, collection bottle, and cannula must be capable of being changed between patients. The powered suction pump has a motor with a minimum of 1/3 horsepower, a variable vacuum range from 0 to 29.9 inches of mercury, vacuum control valves to regulate the vacuum with accompanying vacuum gauges, a single or double rotary vane (with or without oil), a single or double diaphragm, a single or double piston, and a safety trap.", + "output": "SYSTEM, SUCTION, LIPOPLASTY (Medical Device)" + }, + { + "input": "Definition: something described as west Haven Hepatic Encephalopathy Grade test name.", + "output": "CC-West Haven Criteria TEST (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as vegetable charcoal.", + "output": "carbo vegetabilis/vegetable (Pharmacologic Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as tropomyosin alpha-3 chain isoform 2 (248 aa, ~30 kDa) is encoded by the hTM5 allele of the human TPM3 gene. This protein plays a role in the stabilization of the actin cytoskeleton.", + "output": "Tropomyosin Alpha-3 Chain Isoform 2 (TPM3 Gene Product)" + }, + { + "input": "Definition: Professional or Occupational Group described as a pathologist that submits a proposal or letter of intent to participate in a study or who submits results or diagnoses for use in a study.", + "output": "Submitting Pathologist (Professional or Occupational Group)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by Turnbull et al in 1992, which measures the level of bladder function and control, as well as the extent to which bladder problems have an impact on everyday activities. The questionnaire contains 4 questions which are scored ranging from 0 (not at all) to 4 (daily).", + "output": "BLCS01 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as an indication that an individual's growth plates are open and that bone growth is likely to continue.", + "output": "Skeletally Immature (Finding)" + }, + { + "input": "Definition: something described as a plant genus. The distilled essential oil is approximately 1/3 borneol and 1/8 CAMPHOR.", + "output": "Micromerias (Mentheae)" + }, + { + "input": "Definition: something described as a genus of RNA viruses in the family BIRNAVIRIDAE infecting fish, mollusks, and crustaceans. It is transmitted both vertically and horizontally with no known vectors. The natural hosts are salmonids and the type species is INFECTIOUS PANCREATIC NECROSIS VIRUS.", + "output": "Aquabirnavirus (Virus)" + }, + { + "input": "Definition: BMP Receptor Signaling Pathway described as a series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule.", + "output": "BMP signaling pathway involved in Malpighian tubule cell chemotaxis (Molecular Function)" + }, + { + "input": "Definition: Breast Cancer Clinical TNM Finding v6 described as a clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor.", + "output": "Breast Cancer Clinical Primary Tumor TNM Finding v6 (Finding)" + }, + { + "input": "Definition: something described as this gene is involved in the regulation of gene expression and plays a role in the development of squamous cell carcinoma.", + "output": "MicroRNA 133a-1 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a question about an individual's current ability to do their usual activities.", + "output": "Usual Activities Today (Intellectual Product)" + }, + { + "input": "Definition: Necrosis of anatomical site described as a necrotic process affecting the pancreas.", + "output": "pancreas; necrosis (Necrosis of anatomical site)" + }, + { + "input": "Definition: Finding described as a subjective answer of strong agreement.", + "output": "Very (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Congenital Disorders described as a rare genetic congenital secondary polycythemia disorder characterized by increased hemoglobin, hematocrit and erythropoietin serum levels and normal oxygen affinity, which usually manifests with headache, dizziness, dyspnea and/or plethora. Patients present an increased risk of hemorrhage, thrombosis and early death. There is evidence this disease is caused by homozygous or compound heterozygous mutation in the VHL gene on chromosome 3p25.", + "output": "Von Hippel Lindau dependent polycythaemia (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Enter the highest score on any 1 of the 4 sleep items.", + "output": "QIDSR1-Highest Score Sleep Items (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's distress related to their practical problems with insurance or finances.", + "output": "Distress over Practical Problem with Insurance or Finances (Findings-Based Question)" + }, + { + "input": "Definition: something described as an employment agreement where the employer pays an arranged amount at a steady yearly interval regardless of hours worked.", + "output": "Salaried annual (Functional Concept)" + }, + { + "input": "Definition: disorder of propionate metabolism described as increased concentration of methylmalonic acid in the blood.", + "output": "Methylmalonic aciduria (Non-amino organic acidemia AND/OR aciduria)" + }, + { + "input": "Definition: something described as a malignant peripheral nerve sheath tumor occurring during adulthood. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7814\" active clinical trials using this agent.", + "output": "neurofibrosarcoma, adult (Neoplastic Process)" + }, + { + "input": "Definition: something described as a membrane protein and MHC class I antigen. It contains an IMMUNOGLOBULIN C1-SET DOMAIN and interacts with BETA 2-MICROGLOBULIN. It may also regulate the interaction of TRANSFERRIN with the TRANSFERRIN RECEPTOR. Mutations in the HFE gene are associated with cases of FAMILIAL HEMOCHROMATOSIS.", + "output": "HFE Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.", + "output": "SA node cell differentiation (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as tissue factor (295 aa, ~33 kDa) is encoded by the human F3 gene. This protein is involved in both binding to coagulation factor VII and the initiation of blood coagulation.", + "output": "Factor III (Immunologic Factor)" + }, + { + "input": "Definition: positive regulation of mesoderm development described as any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry.", + "output": "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry (positive regulation of mesoderm development)" + }, + { + "input": "Definition: Supratentorial Cistern described as a discrete space situated dorsal to the midbrain where the arachnoid mater and pia mater are separated, and through which a number of important vascular structures pass, including the great cerebral vein, the basal vein of Rosenthal, and the posterior cerebral artery.", + "output": "Superior Supratentorial Cistern (Supratentorial Cistern)" + }, + { + "input": "Definition: something described as a question about an individual's distress from their mouth sores.", + "output": "Mouth sores (Intellectual Product)" + }, + { + "input": "Definition: Qualitative Concept described as quality of firmness produced by cohesion of the particles composing a substance, observed by its inflexibility or resistance to indentation or distortion.", + "output": "Hardnesses (Mechanical Phenomena)" + }, + { + "input": "Definition: cellular diagnosis, AIDS-related lymphoma described as a morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.", + "output": "AIDS Related Immunoblastic Large Cell Lymphoma (Non-Hodgkin lymphoma associated with Human immunodeficiency virus infection)" + }, + { + "input": "Definition: Investigations, CTCAE described as a finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.", + "output": "Fibrinogen Decreased, CTCAE (Finding)" + }, + { + "input": "Definition: Pus cells present described as the presence of white blood cells (LEUKOCYTES) in the urine. It is often associated with bacterial infections of the urinary tract. Pyuria without BACTERIURIA can be caused by TUBERCULOSIS, stones, or cancer.", + "output": "Pus cells in urine (Abnormal urine)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets", + "output": "neoplasm/cancer radioimmunotherapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Swallowing status: esophageal phase described as the location of the pain is in the upper and middle region of the abdomen, located within the sternal angle.", + "output": "Epigastric Pain (Abdominal Pain)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's observation of the worst severity they have experienced related to decreased sexual interest over the past seven days.", + "output": "In the past 7 days, what was the severity of your decreased sexual interest at its worst (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Drop - Unit of Volume described as a unit of volume in British Imperial system equal to 1/36 fluid dram or approximately 99 microliters.", + "output": "Drop (Quantitative Concept)" + }, + { + "input": "Definition: medications and vaccines described as a group of organic or inorganic substances capable of preventing the genotoxic and carcinogenic effects of free-radical compounds. Antioxidants bind to and neutralize ('scavenge') free radicals, thereby transforming them into non-toxic compounds and blocking their genotoxic and carcinogenic effects. This class of agents includes the vitamins C and E, the carotenoids, and selenium. Organic antioxidants are found in high concentrations in fruits, seeds and vegetables.", + "output": "Anti-Oxidants (medications and vaccines)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 5, Word 9.", + "output": "ADNI AVLT - List A Recall 5 Word 9 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: something described as specification for unambiguously describing the structure of chemical molecules using short ASCII strings. SMILES strings can be imported by most molecular editors for conversion back into two-dimensional drawings or three-dimensional models for the molecules.", + "output": "Simplified Molecular Input Line Entry System (Document type)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cytoplasmic receptor and peroxin that contains a series of WD40 REPEATS and binds to PEROXISOME TARGETING SIGNAL 2. It is essential for protein import into PEROXISOMES; mutations in the human PEX7 gene are associated with PEROXISOMAL DISORDERS such as Type 1 CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC.", + "output": "PTS2 Receptors (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as a naturally occurring, bright green, fibrous amphibole asbestos mineral found in metamorphic rocks and as a contaminant in amosite asbestos. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Actinolite asbestos is a known human carcinogen.", + "output": "Actinolite Asbestos (Asbestos)" + }, + { + "input": "Definition: Safety described as identifies the presence of or use of prosthetics, implants, or corrective devices and modifies nursing care as indicated for planned procedure.", + "output": "Assesses presence of prosthetics, implants, or corrective devices (Health Care Activity)" + }, + { + "input": "Definition: something described as a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.", + "output": "excitatory postsynaptic potential (regulation of postsynaptic membrane potential)" + }, + { + "input": "Definition: something described as a species of facultatively anaerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria. This species is nonmotile, oxidase negative, ferments sucrose, hydrolyzes esculin and reduces nitrate. E. asburiae is endophytic in many plant species and an opportunistic pathogen in humans, causing community acquired pneumonia.", + "output": "Enterobacter muelleri Kampfer et al. 2015 (Enterobacter cloacae complex)" + }, + { + "input": "Definition: Medical Device described as prepackaged collections (either custom or standard) of the necessary equipment and supplies for healthcare personnel to use for thorough cleaning and hard rubbing (i.e., scrubbing) of the hands and arms before surgery or other procedures that require a certain level of cleansing by participating personnel in order to reduce/prevent the transmission of infection to patients. These trays (also known as kits) typically include a scrub brush impregnated with an antimicrobial soap/solution (e.g., povidone-iodine, chloroxylenol, etc.) and are packaged as single-use, sterile items.", + "output": "Surgical Scrub Trays (Procedure Kit/Trays)" + }, + { + "input": "Definition: something described as heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.", + "output": "Benzothiadiazines (Thiazides)" + }, + { + "input": "Definition: something described as the highest federal court in the United States, consisting of nine justices and having jurisdiction over all other courts in the nation.", + "output": "US SUPREME COURT (Organization)" + }, + { + "input": "Definition: Abdominal Muscles described as the group of muscles in the torso that are closest to the spine and furthest from the skin such as the psoas muscle and the quadratus lumborum.", + "output": "Deep Abdominal Muscle (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a rare malignant soft tissue neoplasm of uncertain differentiation, characterized by the presence of chondroblast-like cells in a myxoid stroma and a multinodular growth pattern. The most common sites of involvement are the deep soft tissues of the extremities, particularly the thigh. It usually presents as an enlarging soft tissue mass. Patients may have long survivals, but local recurrences and metastases occur in approximately half of the cases. The most common site of metastasis is the lungs.", + "output": "Extraskeletal myxoid chondrosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate.", + "output": "glutamate catabolic process to butyrate (Molecular Function)" + }, + { + "input": "Definition: Hospital Administration described as reorganization of the hospital corporate structure.", + "output": "HOSP REORGAN (Hospital Administration)" + }, + { + "input": "Definition: Cell Function described as a process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.", + "output": "protein localization to cell surface (Cell Function)" + }, + { + "input": "Definition: something described as classification of substance use data.", + "output": "SUSCAT (Classification)" + }, + { + "input": "Definition: Gene Abnormality described as an increase in the copy number of a particular gene. This type of abnormality can be either inherited or somatic.", + "output": "Gene Amplification (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(11;12)(q23;q13) which fuses exon 9 of the MLL gene to most of the SARNP gene. This rearrangement is associated with acute myelomonocytic leukemia.", + "output": "MLL/CIP29 FUSION GENE (Gene or Genome)" + }, + { + "input": "Definition: CHART-SF Paper Version Questionnaire Question described as craig Handicap Assessment and Reporting Technique-Short Form Paper Version - With how many strangers have you initiated a conversation in the last month?", + "output": "CHART-SF Paper Version - Initiated Conversation With Strangers Last Month (Intellectual Product)" + }, + { + "input": "Definition: Kidney Diseases described as the presence of calculi (stones) in the kidneys.", + "output": "NEPHROLITHIASIS (Abnormal renal morphology)" + }, + { + "input": "Definition: something described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Did you need to rest?", + "output": "EORTC QLQ-C30 Version 3 - Did You Need to Rest (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (November 2002) - Long Last 7 Days Telephone Format - During the last 7 days, on how many days did you do vigorous physical activities in your leisure time?", + "output": "IPA0222 (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)" + }, + { + "input": "Definition: Body Space or Junction described as substructures of the third ventricle. They include the infundibular recess, the suprapineal recess, the pineal recess and the optic recess in primates ( Carpenter-1983 ) and the mammillary recess in rodents ( Paxinos-2001; Swanson-1998 ).", + "output": "recesses of third ventricle (Body Space or Junction)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.", + "output": "promoter-specific chromatin binding (chromatin binding)" + }, + { + "input": "Definition: Nervous system neoplasms malignant NEC described as cancer that arises in immature nerve cells and affects mostly infants and children.", + "output": "NEUROBLASTOMA (Nervous System Neoplasms)" + }, + { + "input": "Definition: Mania, CTCAE described as mild manic symptoms", + "output": "Grade 1 Mania, CTCAE (Mania, CTCAE)" + }, + { + "input": "Definition: C-SSRS Baseline/Screening Version Questionnaire Question described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Have you started to work out or worked out the details of how to kill yourself? Do you intent to carry out this plan? (Past X Months).", + "output": "CSS0405B (C-SSRS Baseline/Screening Version Questionnaire Question)" + }, + { + "input": "Definition: sphingolipid transfer activity described as removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.", + "output": "ceramide carrier activity (sphingolipid transfer activity)" + }, + { + "input": "Definition: Carboxy-Lyases described as catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.", + "output": "alpha Ketoacid Carboxylase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as cup-like receptacles designed to be placed in the vagina in order to collect menstrual fluid.", + "output": "Collectors, Menstrual Fluid (Collector device)" + }, + { + "input": "Definition: something described as diabetes Distress Scale for Partners of Adults with Type 1 Diabetes - During the past month, I have been: Feeling that my partner doesn't try hard enough to manage his/her diabetes.", + "output": "PARTNER-DDS - Partner Doesn't Try Hard Enough (PARTNER-DDS Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid.", + "output": "cyclic 2,3-bisphospho-D-glycerate biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Numbers described as an indication of the number of metastatic tumors detected.", + "output": "Number of metastases (Numbers)" + }, + { + "input": "Definition: something described as the modification of an RNA molecule by removal of a uridine nucleotide.", + "output": "RNA uridine excision (Genetic Function)" + }, + { + "input": "Definition: plasmatocyte differentiation described as the process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte.", + "output": "lymph gland plasmatocyte differentiation (larval lymph gland hemocyte differentiation)" + }, + { + "input": "Definition: DNA-binding transcription factor activity described as interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.", + "output": "DNA-binding transcription activator activity (Genetic Function)" + }, + { + "input": "Definition: something described as the known quantity of intake in one day of a polyunsaturated, omega 3 fatty acid with a 22-carbon chain and six cis double bonds.", + "output": "Measured intake of docosahexaenoic acid in 24 hours (Quantitative Concept)" + }, + { + "input": "Definition: Chromosomes described as a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.", + "output": "Nuclear chromosome (Cell Component)" + }, + { + "input": "Definition: Callyspongiidae described as a genus of SPONGES in the family Callyspongiidae comprised of a regular ectosomal reticulate skeleton.", + "output": "Callyspongias (Porifera)" + }, + { + "input": "Definition: benzamide described as a benzamide derivative that is used as a dopamine antagonist.", + "output": "Monohydrochloride, Tiapride (Pharmacologic Substance)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any elsewhere undefined miscellaneous chiropractic service, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.", + "output": "Undefined miscellaneous chiropractic service narrative required (Chiropractic Strapping)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as performing electronic range-of-motion test(s) on a client's extremity or extremities excluding his or her hands. Service is billed in 15-minute increments.", + "output": "lctrnc tst xtrmtW/O hnds ea. (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Imaging, Three-Dimensional described as use of a computer and scanning devices to create three-dimensional pictures.", + "output": "stereotaxis (Imaging, Three-Dimensional)" + }, + { + "input": "Definition: Tricyclic Antidepressive Agents described as the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property. Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action.", + "output": "TRIMIPRAMINE MALEATE (Tricyclic Antidepressive Agents)" + }, + { + "input": "Definition: something described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage 0 Squamous Cell Carcinoma of the Hypopharynx (Hypopharyngeal Squamous Cell Carcinoma)" + }, + { + "input": "Definition: regulation of gene silencing by RNA described as any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.", + "output": "negative regulation of gene silencing by RNA (negative regulation of gene silencing)" + }, + { + "input": "Definition: Finding described as mild symptoms; no anxiety; intervention not indicated", + "output": "Grade 1 Laryngopharyngeal dysesthesia (Laryngopharyngeal Dysesthesia, CTCAE)" + }, + { + "input": "Definition: something described as stretchers that can be converted from stretcher to chair and back to stretchers, usually without transferring the patient from them.", + "output": "Chair/Stretchers (Medical Device)" + }, + { + "input": "Definition: Cell Function described as the directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.", + "output": "acetyl-CoA transport (coenzyme transport)" + }, + { + "input": "Definition: something described as a form of Parkinson disease with age of onset of more than 50 years, tremor at rest, gait complaints and falls, bradykinesia, rigidity and painful cramps. Patients usually present a low risk of developing non-motor symptoms, dystonia, dyskinesia and levodopa-induced dyskinesia. The exact etiology is still unknown but mutations in the genes SNCA (4q21.3-q22), LRRK2 (12q12), and VPS35 (16q12) have been implicated in its pathogenesis. Transmission is autosomal dominant.", + "output": "Parkinson disease autosomal dominant late onset (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: something described as the hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.", + "output": "Ketamine hydrochloride (NMDA receptor antagonist)" + }, + { + "input": "Definition: Electrophoresis, Gel, Two-Dimensional described as methods of comparing two or more samples on the same two-dimensional gel electrophoresis gel.", + "output": "2-Dimensional Difference Gel Electrophoresis (Laboratory Procedure)" + }, + { + "input": "Definition: Arachnoid Cysts described as an arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards.", + "output": "Suprasellar arachnoid cyst (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as asymptomatic", + "output": "Grade 1 Esophageal fistula (Finding)" + }, + { + "input": "Definition: RNA phosphodiester bond hydrolysis described as the chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.", + "output": "RNA phosphodiester bond hydrolysis, exonucleolytic (RNA phosphodiester bond hydrolysis)" + }, + { + "input": "Definition: something described as short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.", + "output": "Fatty Acid, Short-Chain (Biologically Active Substance)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days: How much have you been emotionally affected by your health condition?", + "output": "WHODAS 2.0 36-item Version Self-administered - Emotionally Affected by Health (Intellectual Product)" + }, + { + "input": "Definition: response to oxygen-containing compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus.", + "output": "response to thapsigargin (Physiologic Function)" + }, + { + "input": "Definition: something described as group activities directed against VACCINATION.", + "output": "Groups, Anti-Vaccine (Social Behavior)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.", + "output": "regulation of natural killer cell mediated immune response to tumor cell (regulation of natural killer cell mediated immunity)" + }, + { + "input": "Definition: Intellectual Product described as national Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Self-Administered Format - Difficulty With Activities: How much difficulty do you have driving in difficult conditions, such as in bad weather, during rush hour, on the freeway, or in city traffic? Would you say you have:", + "output": "VFQ25-Self Administered Format - Driving in Difficult Condition (Intellectual Product)" + }, + { + "input": "Definition: Eardrum & Middle Ear: Repair described as surgical restoration of a perforated tympanic membrane by grafting.", + "output": "myringoplasty by graft (Otoplasty)" + }, + { + "input": "Definition: Finding described as an increase in the level of galactitol in the plasma.", + "output": "Increased level of galactitol in plasma (Abnormal circulating carbohydrate concentration)" + }, + { + "input": "Definition: something described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Telephone Format - How much time did you usually spend walking on one of those days?: Minutes per day.", + "output": "IPA0106B (Intellectual Product)" + }, + { + "input": "Definition: something described as the procedures through which a group approaches, attacks, and solves a common problem.", + "output": "Group Processes (Social Behavior)" + }, + { + "input": "Definition: Biologically Active Substance described as DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.", + "output": "rdna (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Approach Anatomic Site Laterality Code described as a coded value specifying the side of the body (or a paired organ) that is an access point for a procedure.", + "output": "PerformedProcedure.approachAnatomicSiteLateralityCode (Approach Anatomic Site Laterality Code)" + }, + { + "input": "Definition: Pharmacologic Substance described as a viral vaccine comprised of a recombinant fowlpox vector construct encoding a modified epitope of the melanoma antigen glycoprotein 100 (gp100), ES-2092M(gp100), containing an endoplasmic reticulum signal sequence targeted to the endoplasmic reticulum apparatus. Vaccination with recombinant fowlpox-gp100p209 vaccine may stimulate the host immune system more efficiently to mount a cytotoxic T lymphocyte response against tumor cells expressing the gp100 antigen.", + "output": "rF-gp100p209 (fowlpox virus vaccine)" + }, + { + "input": "Definition: Curettes, Dental described as curettes designed for excising tissue usually to clean out and/or remove debris from infected cavities in bone and/or tooth sockets during surgical procedures in the oral cavity. These curettes typically consist of handheld, manual instruments with a working end that resembles a solid spoon with sharp edges and a handle at the other end. Oral surgery/dental curettes can be various sizes either with straight or angled shapes according to the nature and location of the bone cavity or tooth socket.", + "output": "Curettes, Dental/Oral Surgery (Curettes, Dental)" + }, + { + "input": "Definition: something described as an area of cerebral cortex defined on the basis of cytoarchitecture in the macaque. The area labeled FC was described together with area FCBm of Bonin and area FCop of Bonin as \\\"a zone which surrounds the frontal lobe... anterior to the agranular cortex... which contains but a feeble granular layer.\\\" The authors regarded it as homologous to area FC of the human as defined by Economo ( Bonin-1947 ).", + "output": "area FC of Bonin (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Disease or Syndrome described as viral infections that may be transmitted between non-human animals and HUMANS.", + "output": "Infection, Zoonotic Viral (Zoonoses)" + }, + { + "input": "Definition: Ability to self-administer medication described as personal actions to administer oral and topical medications to meet therapeutic goals independently with or without assistive device", + "output": "Self-care: non-parenteral medication (Individual Behavior)" + }, + { + "input": "Definition: Intellectual Product described as residual Wilms' tumor confined to the abdomen; Lymph nodes in the renal hilum, the periaortic chains, or beyond are found to contain tumor; diffuse peritoneal contamination by the tumor; implants are found on the peritoneal surfaces; tumor extends beyond the surgical margins either microscopically or grossly; tumor is not completely resectable because of local infiltration into vital structures.", + "output": "SIOP/COG/NWTSG Stage III (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as the progression of the symbiont from an initial condition to a later condition, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction.", + "output": "development of symbiont in host vacuole (development of symbiont in host cell)" + }, + { + "input": "Definition: FHS CVD 10-Year Risk Score Clinical Classification Question described as framingham Heart Study Cardiovascular Disease 10-Year Risk Score (FCVD1-Framingham CVD 10-Year Risk Score) Risk score.", + "output": "FCVD1-Framingham CVD 10-Year Risk Score (Finding)" + }, + { + "input": "Definition: UML Entity described as a collection of Privilege objects. Indicates which privileges belong to this role.", + "output": "Privileges (UML Entity)" + }, + { + "input": "Definition: something described as any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.", + "output": "regulation of establishment of BBB (regulation of nervous system development)" + }, + { + "input": "Definition: CPTAC Responses described as a response indicating that local anesthesia agents were administered.", + "output": "Local Anesthesia Agents were Administered (Finding)" + }, + { + "input": "Definition: Radiation therapy complication described as a rare neurological disease characterised by the development of paraesthesia as well as in severe cases progressive paresis and paralysis following irradiation of tumours in which the spinal cord is included within the radiation field. Symptoms may develop months or years after radiation therapy was administered.", + "output": "Radiation myelitis (Back Injuries)" + }, + { + "input": "Definition: Peptic Ulcer described as peptic ulcer located in the duodenum, the shortest and widest portion of the small intestine adjacent to the pylorus of the stomach.", + "output": "Duodenal ulcer disease (gastrointestinal)" + }, + { + "input": "Definition: Cell Function described as the directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6.", + "output": "short-chain fatty acid transport (Cell Function)" + }, + { + "input": "Definition: Health Care Related Organization described as residential treatment centers for individuals with leprosy.", + "output": "Leper Colonies (Health care facility)" + }, + { + "input": "Definition: BPRS 1988 Version Clinical Classification Question described as brief Psychiatric Rating Scale 1988 Version - Hostility.", + "output": "BPRS01-Hostility (Intellectual Product)" + }, + { + "input": "Definition: Nodular pattern on pulmonary HRCT described as a nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases.", + "output": "Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT (Nodular pattern on pulmonary HRCT)" + }, + { + "input": "Definition: gated channel activity described as enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.", + "output": "mechanically-gated channel activity (gated channel activity)" + }, + { + "input": "Definition: Pylorospasm described as an abnormality characterized by thickening of the muscle in the wall of the pylorus. It results in the narrowing of the pyloric channel. The overlying mucosa may appear hypertrophic as well. Clinical signs and symptoms appear early in life and include projectile vomiting and dehydration.", + "output": "STENOSIS PYLORIC HYPERTROPHIC CONGENITAL (gastrointestinal)" + }, + { + "input": "Definition: Neurological device described as an electroencephalograph is a device used to measure and record the electrical activity of the patient's brain obtained by placing two or more electrodes on the head.", + "output": "electroencephalograph (Standard EEG machine)" + }, + { + "input": "Definition: Finding described as a rating of a body of water based on measurable physical, chemical, and biological characteristics.", + "output": "water quality (Finding)" + }, + { + "input": "Definition: Organ or Tissue Function described as the regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system.", + "output": "androstenedione secretion (lipid export from cell)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores.", + "output": "sporocyte differentiation (Cell Function)" + }, + { + "input": "Definition: Metabolic disorders NEC described as abnormally low levels of aldosterone in the blood.", + "output": "Hypoaldosteronemia (Adrenal gland hypofunction)" + }, + { + "input": "Definition: Finding described as a response that evidence of disease is unknown after completion of therapy.", + "output": "Evidence of Disease Unknown after Completion of Therapy (Finding)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Additional Concerns: I feel weak all over.", + "output": "FAC017-I Feel Weak All Over (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: inorganic anion transmembrane transporter activity described as enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.", + "output": "sulfate transmembrane transporter activity (inorganic anion transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a standardized rating scale developed by Leonard Handelsman and colleagues in 1987 to evaluate the severity of an individual's opiate withdrawal signs and symptoms. This instrument contains 16 items or symptoms that pertain to opiate withdrawal, which are completed by the individual. Each item is rated on a scale of 0 to 4 with 0 being not at all and 4 being extremely.", + "output": "SOWS Subjective (Intellectual Product)" + }, + { + "input": "Definition: L-phenylalanine biosynthetic process described as the chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.", + "output": "L-phenylalanine anabolism from chorismate via phenylpyruvate (chorismate metabolic process)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid dosage form, usually in the shape of a square or rectangle.", + "output": "Block Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Bacteria, Yersinia Species, Antibody described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to species of Yersinia, a genus of ovoid-shaped bacteria of the family Enterobacteriaceae. Yersinia species that are pathologic to humans include Y. pestis, which causes bubonic plague; Y. enterocolitica, which causes acute gastroenteritis and mesenteric lymphadenitis; and Y. pseudotuberculosis, which causes mesenteric lymphadenitis without gastroenteritis.", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Yersinia Species, IgG Antibody (Medical Device)" + }, + { + "input": "Definition: something described as a coded value specifying special handling requirements for the device. EXAMPLE(S): keep at room temperature, store upright OTHER NAME(S): NOTE(S):", + "output": "Device Handling Code (Intellectual Product)" + }, + { + "input": "Definition: antiporter described as an electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.", + "output": "Calcium Sodium Antiporter (antiporter)" + }, + { + "input": "Definition: Numeric Test Result described as the numerical identifier of vital signs result data in standard units.", + "output": "Vital Signs Numeric Result in Standard Unit (Quantitative Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as the branch of pathology that focuses the causes and nature and effects of diseases of the lungs and respiratory structures.", + "output": "Pulmonary Pathology (Disease or Syndrome)" + }, + { + "input": "Definition: AKT Inhibitor described as an orally bioavailable pan inhibitor of the serine/threonine protein kinase AKT (protein kinase B) enzyme family with potential antineoplastic activity. Upon oral administration, AKT inhibitor ARQ 751 selectively binds to and inhibits the activity of the AKT isoforms 1, 2 and 3, which may result in the inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. This may lead to a reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C128250\" active clinical trials using this agent.", + "output": "ARQ 751 (Pharmacologic Substance)" + }, + { + "input": "Definition: Hematopoietic Cell Transplantation Conditioning Regimen described as a chemotherapeutic regimen composed of busulfan and melphalan used as a conditioning regimen for stem cell transplantation (SCT).", + "output": "BuMel regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the metarubricytes to leukocytes in a biological sample. The measurement may be expressed as either a ratio or a percentage.", + "output": "METARBLE (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: UPDRS Questionnaire Question described as unified Parkinson's Disease Rating Scale - Activities of daily living (for both 'on' and 'off'): Cutting food and handling utensils.", + "output": "UPD1-Activities:Cut Food/Handle Utensil (Intellectual Product)" + }, + { + "input": "Definition: something described as systems designed to continuously acquire, measure, process, and display biologic, technical, environmental, or other data from one or more patients, devices, or other targets. These systems typically consist of a central station monitor that receives, consolidates, and displays information from a set of monitors and/or appropriate sensors (e.g., temperature, pressure) that are deployed throughout a healthcare area; cables and/or wireless links; computerized processing units; and display monitors. Dedicated monitoring systems are typically used in healthcare facilities to monitor physiologic and clinical laboratory parameters; other monitoring systems may be used to monitor technical and safety characteristics (e.g., radiation levels, presence of pathogens), and environmental data.", + "output": "monitor system (Monitors & Monitoring Systems & Physiologic Monitor Modules)" + }, + { + "input": "Definition: something described as primary repair of injured organ/structure indicated", + "output": "Grade 1 Intraoperative urinary injury (Intraoperative Urinary Injury, CTCAE)" + }, + { + "input": "Definition: something described as a character or string that represents the short code name of the finding of the event or intervention.", + "output": "FATESTCD (Test Code)" + }, + { + "input": "Definition: Non-synonymous ALK Gene Mutation described as a nucleotide substitution at position 3520 of the coding sequence of the ALK gene where thymine has been mutated to cytosine.", + "output": "Anaplastic Lymphoma Receptor Tyrosine Kinase c.3520T>C (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as abnormal release of dense granules from platelets.", + "output": "Abnormal platelet dense granule secretion (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human TFE3 wild-type allele is located in the vicinity of Xp11.22 and is approximately 17 kb in length. This allele, which encodes transcription factor E3 protein, plays a role in the regulation of immunoglobulin expression. The gene is involved in chromosomal aberrations that are associated with papillary renal cell carcinoma and alveolar soft part sarcoma.", + "output": "TFEA (TFE3 gene)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 12q", + "output": "12q13-q15 (Cell Component)" + }, + { + "input": "Definition: Pharmacologic Substance described as glycopeptides that have an additional lipophilic side chains. Several semisynthetic lipoglycopeptide antibiotics are derived from naturally occurring lipoglycopeptide and glycopeptide antibiotics.", + "output": "Lipoglycopeptides [EXT] (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a dose calculation unit expressed in milliliter(s) per animal.", + "output": "Milliliter per Animal (Unit of Dose Calculation)" + }, + { + "input": "Definition: negative regulation of voltage-gated potassium channel activity described as any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.", + "output": "down regulation of Kir channel activity (regulation of inward rectifier potassium channel activity)" + }, + { + "input": "Definition: Benign neoplasm of thyroid gland described as a rare benign vascular neoplasm that arises from the thyroid gland. This category includes hemangiomas, cavernous hemangiomas, and lymphangiomas.", + "output": "Thyroid Gland Benign Vascular Neoplasm (Benign vascular neoplasm)" + }, + { + "input": "Definition: something described as hours times picomoles per milliliter.", + "output": "pmol*h/mL (Measurement Unit Description)" + }, + { + "input": "Definition: Measure of pregnancy described as the best estimated due date is determined by: last menstrual period (LMP) if confirmed by early ultrasound or no ultrasound performed, or early ultrasound if no known LMP or the ultrasound is not consistent with LMP, or known date of fertilization (e.g. Assisted Reproductive Technology (ART), Intrauterine Insemination (IUI)).", + "output": "baby's due date (Finding)" + }, + { + "input": "Definition: Third generation cephalosporin described as the sodium salt form of ceftizoxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Ceftizoxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.", + "output": "Epocelin (C [Preparations])" + }, + { + "input": "Definition: Medical Device described as dedicated laboratory incubators designed to provide mechanical mixing (either by shaking, rotation, or both) to platelet containers placed in the incubator chamber. These incubators typically include a corrosion-resistant chamber with appropriate racks for a variety of containers; a mechanism that provides the mechanical movement; devices for accurate cooling and/or heating the chamber; speed, temperature, and door-opening controls; local and remote alarms; and recording devices to keep a detailed record of all the events during platelet storage. Platelet laboratory shaker/rotator incubators are available in stand-alone and tabletop models.", + "output": "Incubators, Laboratory, Shaker/Rotator, Platelet (Incubators, Laboratory, Shaker/Rotator)" + }, + { + "input": "Definition: Pharmacologic Substance described as any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.", + "output": "DNA Topoisomerase Inhibitor (Enzyme Inhibitors)" + }, + { + "input": "Definition: Testing Was Performed described as an indication that 1p/19q deletion analysis was performed during the study.", + "output": "1p/19q Deletion Analysis Was Performed (Finding)" + }, + { + "input": "Definition: something described as a fusion gene that results from a chromosomal rearrangement either t(3;3)(q21;q26) or inv(3)(q21q26) which fuses the promoter sequences from the GATA2 gene on either the 5' or 3' side of the coding sequence of the MECOM gene. This rearrangement is associated with overexpression of the histone-lysine N-methyltransferase MECOM protein and 3q21q26 syndrome-related leukemias.", + "output": "GATA2/MECOM Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: Atherectomy Device Characteristics described as the length of the tip of the atherectomy device, if present.", + "output": "Atherectomy Device Tip Length (Quantitative Concept)" + }, + { + "input": "Definition: Organic Chemical described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.", + "output": "cresyl blue (Organic Chemical)" + }, + { + "input": "Definition: Governmental or Regulatory Activity described as legislation, regulations and standards that govern the moving of persons or goods by road, paths, rail, air or water, such as transportation planning acts and policies, policies for the provision and access to public transportation.", + "output": "Transportation policies (Transportation services, systems and policies)" + }, + { + "input": "Definition: something described as a dose calculation unit expressed in milliliter(s) per cage.", + "output": "mL/cage (Unit of Dose Calculation)" + }, + { + "input": "Definition: Cardiovascular Diseases described as any heart disorder characterized by a defect in valve structure or function.", + "output": "Valvular Heart Diseases and Syndromes (Blood, Heart and Circulation)" + }, + { + "input": "Definition: something described as the reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure.", + "output": "penile bone development (Bone Development)" + }, + { + "input": "Definition: something described as the numerical value that represents the result of a clinical assessment of muscle strength and function during dorsiflexion that is based on the Brooke Modified Medical Research Council Manual Muscle Test. (Brooke MH, Griggs RC, Mendell JR, Fenichel GM, et al. Clinical trial in Duchenne dystrophy. I. The design of the protocol. Muscle Nerve. 1981 May-Jun;4(3):186-97. doi:10.1002/mus.880040304).", + "output": "Brooke mMRC MMT Score, Dorsiflexion (Score)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV vulvar cancer is divided into stages IVA and IVB. In stage IVA, the cancer (1) has spread to nearby lymph nodes on both sides of the groin, or (2) has spread beyond nearby tissues to the upper part of the urethra, bladder, or rectum, or (3) is attached to the pelvic bone and may have spread to lymph nodes. In stage IVB, the cancer has spread to distant parts of the body.", + "output": "Stage IV Vulvar Cancer AJCC v6 (Vulval neoplasms malignant)" + }, + { + "input": "Definition: something described as human HSPBAP1 wild-type allele is located in the vicinity of 3q21.1 and is approximately 54 kb in length. This allele, which encodes HSPB1-associated protein 1, may be involved in the regulation of the response to cell stress. A chromosomal translocation t(2;3)(q35;q21) of this gene and the DIRC3 gene is associated with renal cell carcinoma.", + "output": "PASS1 (HSPBAP1 gene)" + }, + { + "input": "Definition: something described as in vitro fertilisation with subsequent transfer to an unrelated surrogate.", + "output": "In vitro fertilisation with surrogacy (Fertilization in Vitro)" + }, + { + "input": "Definition: C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicidality Severity Rating Scale Already Enrolled Subjects (C-SSRS Already Enrolled Subjects ) Total number of interrupted. (Since Study Start).", + "output": "C-SSRS Already Enrolled Subjects - Number of Interrupted Suicide Attempts (C-SSRS Already Enrolled Subjects Questionnaire Question)" + }, + { + "input": "Definition: Finding described as muscle hypertrophy affecting the thighs.", + "output": "Thigh hypertrophy (MUSCLE SOFT, TISSUE)" + }, + { + "input": "Definition: Regimen Used to Treat Hodgkin Lymphoma described as a chemotherapy regimen consisting of doxorubicin hydrochloride (Adriamycin), bleomycin, vinblastine and dacarbazine, used alone or in combination with radiation therapy, for the primary treatment of Hodgkin lymphoma.", + "output": "Adriamycin-Bleomycin-Vinblastine-Dacarbazine Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as stage IIIA includes: T3a, N0, M0. T3a: microscopic peritoneal metastasis outside the pelvis. N0: no regional lymph node metastasis. M0: no distant metastasis.", + "output": "FIGO Stage IIIA Fallopian Tube Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as deoxyribonucleic acid that makes up the genetic material of protozoa.", + "output": "DNA, Protozoan (DNA)" + }, + { + "input": "Definition: something described as positive and Negative Syndrome Scale - Motor retardation.", + "output": "PANSS - Motor Retardation (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as a vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.", + "output": "Red, Toluylene (Dyes)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's ability to write letters or notes.", + "output": "Writing (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life (PedsQL) Neuromuscular Module Acute Version 3 Young Adult Parent Report (Copyright 1998 JW Varni, Ph.D. Iannaccone, S.T., Hynan, L.S., Morton, A., Buchanan, R., Limbers, C.A., Varni, J.W., the AmSMART Group (2009). The PedsQL in pediatric patients with Spinal Muscular Atrophy: Feasibility, reliability, and validity of the Pediatric Quality of Life Inventory Generic Core Scales and Neuromuscular Module. Neuromuscular Disorders, 19, 805-812. Davis, S.E., Hynan, L.S., Limbers, C.A., Andersen, C.M., Greene, M.C., Varni, J.W., Iannaccone, S.T. (2010). The PedsQL in pediatric patients with Duchenne Muscular Dystrophy: Feasibility, reliability, and validity of the Pediatric Quality of Life Inventory Neuromuscular Module and Generic Core Scales. Journal of Clinical Neuromuscular Disease, 11, 97-109).", + "output": "PEDSQL NEUROMUSCULAR MODULE ACUTE V3 YOUNG ADULT PARENT REPORT (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as a binary digit, the smallest unit of storage.", + "output": "Bit (Miscellaneous Unit)" + }, + { + "input": "Definition: Increased level described as an elevated concentration of glucagon in the blood circulation. []", + "output": "Increased glucagon level (Abnormal glucagon level)" + }, + { + "input": "Definition: something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated", + "output": "Grade 1 Rectal obstruction (Finding)" + }, + { + "input": "Definition: molecular diagnostics gene rearrangement described as a procedure used to detect and identify rearrangements involving the BRAF gene.", + "output": "BRAF Rearrangement Analysis (molecular diagnostics gene rearrangement)" + }, + { + "input": "Definition: Antibiotic described as an ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.", + "output": "5-(Methylamino)-2-(((2R,3R,6S,8S,9R,11R)-3,9,11-Trimethyl-8-((1S)-1-Methyl-2-Oxo-2-(1H-Pyrrol-2-yl)Ethyl)-1,7-Dioxaspiro(5.5)Undec-2-yl)Methyl)-4-Benzoxazolecarboxylic Acid (Organic Chemical)" + }, + { + "input": "Definition: Streptococcus described as a non-taxonomic grouping of beta-hemolytic species within the Streptococcus genus that are assigned to the F group.", + "output": "BETA STREPTOCOCCUS, GROUP F (Bacterium)" + }, + { + "input": "Definition: purine ribonucleoside metabolic process described as the chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.", + "output": "purine ribonucleoside biosynthetic process (ribonucleoside biosynthetic process)" + }, + { + "input": "Definition: something described as arising from, pertaining to, or having two locations.", + "output": "Bifocal (Spatial Concept)" + }, + { + "input": "Definition: Measurement Unit Description described as hours times picograms per milliliter, divided by meters squared.", + "output": "h*pg/mL/m2 (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the Columbia-Suicide Severity Rating Scale Children's Baseline (C-SSRS Children's Baseline) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).", + "output": "Columbia-Suicide Severity Rating Scale Children's Baseline Questionnaire Test Name (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Have you had pain?", + "output": "EORTC QLQ-C30 Version 3 - Have You Had Pain (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: something described as the directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.", + "output": "amino acid efflux (export across plasma membrane)" + }, + { + "input": "Definition: rnax cardiovascular care actions described as activities that promote cardiac or circulatory function such as energy conservation and fluid balance.", + "output": "care cardiac (Care of body sites)" + }, + { + "input": "Definition: Malignant Neoplasms described as cancer that forms in a parotid gland, the largest of the salivary glands, which make saliva and release it into the mouth. There are 2 parotid glands, one in front of and just below each ear. Most salivary gland tumors begin in parotid glands.", + "output": "parotid cancer (Parotid Neoplasms)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bladder Version 4 - Additional Concerns: I have a good appetite.", + "output": "FAC006-I Have a Good Appetite (Intellectual Product)" + }, + { + "input": "Definition: something described as a procedure performed to bypass partially or completely occluded coronary arteries with veins and/or arteries harvested from elsewhere in the body, thereby improving the blood supply to the coronary circulation supplying the myocardium (heart muscle).", + "output": "Family History of CABG (Family Surgical History)" + }, + { + "input": "Definition: aldehyde oxidase activity described as catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide.", + "output": "aryl-aldehyde oxidase activity (aldehyde oxidase activity)" + }, + { + "input": "Definition: Quantitative Concept described as a dose calculation unit expressed in milliliter(s) per square meter.", + "output": "Milliliter per meter squared (Unit of cardiothoracic assessment)" + }, + { + "input": "Definition: Plant Extracts described as chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.", + "output": "Herbal Drugs, Chinese (Plant Extracts)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a radiopharmaceutical consisting of ethylenedicysteine-deoxyglucose (EC-DG) labeled with the metastable radioisotope technetium Tc-99 (99mTc). Upon administration, technetium Tc 99m ethylenedicysteine-deoxyglucose accumulates in cells with increased metabolic activity such as proliferating tumor cells; tumor tissue may then be imaged using gamma scintigraphy.", + "output": "99mTc Ethylenedicysteine-Deoxyglucose (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: HLA class II antigen described as a HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.", + "output": "HLA - Human leucocyte antigen DR7 (HLA class II antigen)" + }, + { + "input": "Definition: Tumor-Related Protein described as melanoma-associated antigen 6 (314 aa, ~35 kDa) is encoded by the human MAGEA6 gene. This protein may enhance ubiquitin ligase activity.", + "output": "Cancer/Testis Antigen 1.6 (Tumor-Related Protein)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 20-aldehyde-leukotriene B4 + O2 + NADPH + H(+) = 20-carboxy-leukotriene B4 + H2O + NADP(+).", + "output": "20-aldehyde-leukotriene B4 20-monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Research Career Programs, K-Series described as the purpose of the NCI Transition Career Development Award (K22) is to provide \"protected time\" for newly independent investigators to develop and receive support for their initial cancer research programs. This award is intended to facilitate the transition of investigators from the mentored to the independent stage of their careers in cancer research. It applies to clinicians who are pursuing basic science careers; clinicians who are pursuing careers in patient-oriented research; and to individuals pursuing careers in the prevention, control and population sciences.", + "output": "K22 Mechanism (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIB includes: T2b N0, M0. T2b: Extension and/or implants on other pelvic tissues. No malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "FIGO Stage IIB Malignant Germ Cell Tumor of Ovary (Stage II Ovarian Germ Cell Tumor AJCC v6 and v7)" + }, + { + "input": "Definition: Antineoplastic Agents described as a drug used to treat certain types of chronic myelogenous leukemia (CML). It is used in patients who have not gotten better after treatment with other anticancer drugs or who are not able to take imatinib mesylate. It is also being studied in the treatment of other types of cancer. Nilotinib blocks a protein called BCR/ABL which is made in CML cells that contain the Philadelphia chromosome (an abnormal chromosome 22 that has part of chromosome 9 attached). It is a type of tyrosine kinase inhibitor.", + "output": "nilotinib (Organic Chemical)" + }, + { + "input": "Definition: Neurologic Examination described as involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.", + "output": "reflexed (Psychophysiology)" + }, + { + "input": "Definition: Proteins described as proteins on the cytoplasmic side of the GOLGI APPARATUS cisternae that tether the cisternae to each other or to the transport vesicles of the TRANS-GOLGI NETWORK to maintain the Golgi structure and function.", + "output": "Protein, Golgi Matrix (Proteins)" + }, + { + "input": "Definition: something described as specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.", + "output": "PHOTORECEPT CELLS VERTEBRATE (Cell)" + }, + { + "input": "Definition: something described as the region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.", + "output": "postsynaptic endocytic zone membrane (Synaptic Membranes)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's physician handles people's emotions very well.", + "output": "Physician Handles People's Emotions Very Well (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: regulation of maintenance of mitotic sister chromatid cohesion described as any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms.", + "output": "regulation of maintenance of mitotic sister chromatin cohesion along arms (Cell Function)" + }, + { + "input": "Definition: something described as gas germicides, whose main component is ethylene oxide, intended for killing and/or total inactivation (i.e., sterilization) of microorganisms (i.e., viruses, bacteria, fungi, and their spores). These gas germicides typically consist of a mixture of ethylene oxide with other inactive components, such as carbon dioxide, nitrogen, or dichlorodifluoromethane.; tThey are used in sterilizing units that include a closed chamber in which the time, temperature, and/or concentration of the germicidal during the sterilization process are controlled. The germicide is toxic and must be eliminated after the sterilization cycle is complete. Ethylene oxide germicides are mainly used to sterilize surgical instruments, reusable supplies, and pharmaceutical products that cannot support conventional high temperature sterilization (e.g., devices that contain plastic or rubber components).", + "output": "Germicides, Gas, Ethylene Oxide (Organic Chemical)" + }, + { + "input": "Definition: Fibrinogen abnormality described as a coagulation disorder characterized by the partial or complete absence of fibrinogen (factor I) activity in the blood.", + "output": "Factor I Deficiency (Blood Coagulation Disorders, Inherited)" + }, + { + "input": "Definition: Antispasmodics described as a combination agent, comprised of belladonna alkaloids and Phenobarbital, with gastrointestinal anticholinergic activity. The belladonna alkaloids produce an anticholinergic effect by the competitive inhibition of acetylcholine at the parasympathetic neuro-effector junction, and the barbiturates produce a sedative effect probably as a result of their inhibition of synaptic neurotransmitters in the central nervous system (CNS).", + "output": "Donnatal (Antispasmodics)" + }, + { + "input": "Definition: Space of ventricular system of brain described as the narrow channel that connects the third ventricle with the lateral ventricle; it is located between the fornix and the dorsal surface of the thalamus ( Gray-1918a; NeuroNames ).", + "output": "Foramen of Monro (Brain part)" + }, + { + "input": "Definition: Malignant neoplasm of large intestine described as the reemergence of colon carcinoma after a period of remission.", + "output": "Recurrent Cancer of the Colon (Intestinal Cancer)" + }, + { + "input": "Definition: something described as a broad ranging concept that incorporates an individual's physical health, psychological state, level of independence, social relationships, personal beliefs, and their relationships to salient features of the environment. NOTE: Quality of life is one way to measure the benefits or negative impacts of an \"improvement\" measured in terms of a physiological or psychological symptom. QoL research seeks to quantify what an intervention means to a patient's sense that their life has changed. NOTE: See also definition from FDA eCOA Glossary.", + "output": "Quality of life finding (health & life quality)" + }, + { + "input": "Definition: Organ segment described as organ segment which is regional part of accessory parotid gland. Examples: duct tree of accessory parotid gland, duct of accessory parotid gland.", + "output": "Accessory parotid gland segment (Organ segment)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.", + "output": "L-aspartate:ammonia ligase (ammonia ligase activity)" + }, + { + "input": "Definition: regulation of late endosome to lysosome transport described as any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport.", + "output": "negative regulation of late endosome to lysosome transport (regulation of late endosome to lysosome transport)" + }, + { + "input": "Definition: something described as a measure of sustained attention where the subject is instructed to respond one way whenever the stimulus is an X that was preceded by an A and another way for all other stimuli, including an A, an X that was not preceded by an A, and any other letter.", + "output": "AX Continuous Performance Test (Intellectual Product)" + }, + { + "input": "Definition: Gamma-aminobutyric Acid (GABA) Augmenting Agents described as a benzodiazepine derivative with anti-anxiety, sedative, hypnotic and anticonvulsant properties. Diazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic system and the hypothalamus. This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.", + "output": "Diazepam [anesthesia] (Muscle Relaxing Drugs)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of two ( Swanson-2004 ) or three ( Paxinos-2009b ) subdivisions of the basolateral nucleus of the amygdala identified by Nissl stain in the rat. The second, reported by both authors, is the anterior part of the basolateral nucleus. The third, if present, is the ventral part of the basolateral nucleus ( Paxinos-2009b ). All three are reported in the mouse ( Dong-2004; Franklin-2008 ).", + "output": "Basolateral nucleus of the amygdala posterior part (basolateral nucleus of the amygdala)" + }, + { + "input": "Definition: carbohydrate derivative binding described as interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.", + "output": "proteoglycan binding (carbohydrate derivative binding)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of volume fraction expressed as a volume of the constituent in cubic meters per the volume of the system represented in cubic meters.", + "output": "meter3/meter3 (Quantitative Concept)" + }, + { + "input": "Definition: Receptor described as membrane-associated progesterone receptor component 1 (195 aa, ~22 kDa) is encoded by the human PGRMC1 gene. This protein may play a role in progesterone uptake.", + "output": "PGRMC1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Numerical value described as the value assigned to the parameter in the context of the use of the device or software. EXAMPLE(S): \"2100\" for the analysis end point for GeneMapper v3.7, \"G5\" for the GeneMapper v3.7 Dye Set G5 for 5 color dye analysis modules. OTHER NAME(S): NOTE(S):", + "output": "Device Parameter Value With Attribute Value (Intellectual Product)" + }, + { + "input": "Definition: Other nasal preparations in ATC described as a component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B.", + "output": "Framycetinum (neomycin)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as a branch of pharmacology concerned with the effects of drugs on the nervous system.", + "output": "neuropharmacology (Neuroscience discipline)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was unable to speak at all.", + "output": "Unable to speak at all (Finding)" + }, + { + "input": "Definition: Functional Concept described as a description of the area or extent of the body that is exposed to radiation. This may include information about the body part that is irradiated as well as procedures that may be done in conjunction with the radiation.", + "output": "BIRRMDL (Model - style/design)" + }, + { + "input": "Definition: something described as matrix metalloproteinase-14 (582 aa, ~66 kDa) is encoded by the human MMP14 gene. This protein is involved in both extracellular matrix proteolysis and the activation of 72 kDa type IV collagenase.", + "output": "MMP-X1 (Matrix Metalloproteinases)" + }, + { + "input": "Definition: something described as a lithium test system is a device intended to measure lithium (from the drug lithium carbonate) in serum or plasma. Measurements of lithium are used to assure that the proper drug dosage is administered in the treatment of patients with mental disturbances, such as manic-depressive illness (bipolar disorder).", + "output": "ATOMIC ABSORPTION, LITHIUM (Medical Device)" + }, + { + "input": "Definition: Paranasal Sinus Cancer described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis.", + "output": "Stage III Paranasal Sinus Carcinoma (Paranasal Sinus Cancer)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as high density small VLDL particles (30-40 nm).", + "output": "VLDL3 Lipoproteins (Biologically Active Substance)" + }, + { + "input": "Definition: Organic Chemical described as a quassinoid phytochemical isolated from the plant Simaba guianensis with potential antineoplastic and antimalarial activities.", + "output": "gutolactone (Organic Chemical)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a substance being studied in the treatment of brain tumors. It combines a protein that binds to certain tumor cells with a bacterial toxin that kills tumor cells.", + "output": "TP-38 immunotoxin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Transitional vertebra described as condition with either the sacralisation of the lowest lumbar segment or the lumbarisation of the most superior sacral segment of the spine.", + "output": "Transitional lumbosacral vertebra (Spinal Diseases)" + }, + { + "input": "Definition: Penile Cancer Pathologic Primary Tumor TNM Finding v8 described as penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion.", + "output": "Penile Squamous Cell Carcinoma pT3 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as assessing the health status of an existing client in a simple, 15-minute, in-facility meeting to develop a treatment plan. This code may be used by practitioners trained to perform client/patient assessments.", + "output": "Simple existing in-facility 15 minutes (Remote location existing client without ICD diagnosis)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - If you answered \"no\" to Question 36 above, was your child's activity limited by: Activity not in season?", + "output": "PODCI Pediatric Parent-Reported Version - Outdoor Limited by: Season (Intellectual Product)" + }, + { + "input": "Definition: PGI Generic Modification Version Questionnaire Question described as patient Global Impression Generic Modification Version (PGI Generic Modification Version) Considering all the ways your condition impacts you, how severe is your condition at this time?", + "output": "PGI0101 (PGI Generic Modification Version Questionnaire Question)" + }, + { + "input": "Definition: something described as the chloride salt form of oxybutynin, a tertiary amine and anticholinergic agent with antispasmodic activity. Oxybutynin chloride exerts its antimuscarinic effect on bladder smooth muscle by blocking muscarinic receptors in smooth muscle, thereby inhibiting acetylcholine binding. This results in a relaxation of bladder smooth muscle, a reduction of involuntary muscle contractions and delays the initial desire to void. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73597\" active clinical trials using this agent.", + "output": "Oxybutynin HCl product (urinary tract antispasmodics)" + }, + { + "input": "Definition: something described as episodic fever that recurs at irregular intervals. []", + "output": "Non-periodic recurrent fever (Finding)" + }, + { + "input": "Definition: Antineoplastic Agents described as a transcription activator-like effector nucleases (TALEN)-edited plasmid targeting the human papillomavirus (HPV) type 16 (HPV16) epitope E6, with potential antineoplastic activity. Upon administration of TALEN-edited HPV16 E6 T27, the TALEN targets and binds to a specific site on genomic HPV16 E6 and cleaves the DNA sequences encoding E6. This causes double-strand DNA (dsDNA) breaks within the viral DNA, which prevents the transcription and translation of E6. Inhibition of E6 expression restores and increases the expression of tumor suppressor genes, such as p53, and proapoptotic protein BAK, and promotes downstream signaling. Altogether, TALEN-based HPV editing increases apoptosis, reduces viral replication and viral load, eliminates HPV and inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16 E6 is an oncogene vital to viral function and HPV infection, and promotes carcinogenesis.", + "output": "T27 (Pharmacologic Substance)" + }, + { + "input": "Definition: SIQ Questionnaire Question described as suicidal Ideation Questionnaire - I thought about writing a will.", + "output": "SIQ01-I Thought About Writing a Will (SIQ Questionnaire Question)" + }, + { + "input": "Definition: something described as performance of the Upper Limb Module for DMD Version 2.0 - Shoulder flexion to shoulder height with 500g weight.", + "output": "PUL0204 (PUL 2.0 Functional Test Question)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.", + "output": "carbohydrate binding (Molecular Function)" + }, + { + "input": "Definition: Cuboidal Epithelium described as unilaminar epithelium, which consists of a single layer of cuboidal cells. Examples: epithelium of proximal renal tubule, pigmented layer of retina, epithelium of lens.", + "output": "Simple cuboidal epithelium (Unilaminar epithelium)" + }, + { + "input": "Definition: Intellectual Product described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Have you felt downhearted and blue?", + "output": "MSQOL-54 - Felt Downhearted and Blue (Intellectual Product)" + }, + { + "input": "Definition: Receptor status described as an indication that expression of GNRHR has been detected in a sample.", + "output": "LRHR Positive (Receptor status)" + }, + { + "input": "Definition: something described as a protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.", + "output": "homotetrameric ADPG pyrophosphorylase complex (Cell Component)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of mass flow rate equal to one picogram per minute.", + "output": "pg/min (Unit of Dose Calculation)" + }, + { + "input": "Definition: something described as a supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.", + "output": "Vertical supranuclear gaze palsy (Disease or Syndrome)" + }, + { + "input": "Definition: Neural Groove described as an embryologic structure that develops as a result of accelerated growth near the margin of the neural plate relative to that of the midline. Two neural folds bound the neural groove ( Carpenter-1983 ).", + "output": "Folds, Neural (Region of neural plate)" + }, + { + "input": "Definition: Organic Chemical described as macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.", + "output": "Tylosin product (Antibiotics)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals.", + "output": "propylene metabolism (Xenobiotic Metabolism)" + }, + { + "input": "Definition: Benign tumor of penis described as a schwannoma that occurs in the penis.", + "output": "Penile Schwannoma (Peripheral Nerve Schwannoma)" + }, + { + "input": "Definition: Intellectual Product described as an expression that conveys significant information about the type of measurement of observation.", + "output": "Measurement Unit Description (Data Element)" + }, + { + "input": "Definition: N1 category described as a general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm); for cutaneous melanoma it refers to micrometastasis in one regional lymph node; for colorectal cancer it refers to metastasis in one regional lymph node.", + "output": "N1a Lymph Node Stage (Finding)" + }, + { + "input": "Definition: Intestinal Diseases described as chemia of the intestine that is rapid in onset.", + "output": "Acute vascular insufficiency of intestine, NOS (Disease or Syndrome)" + }, + { + "input": "Definition: Neurocutaneous Syndromes described as syndrome that may be classified among the neurocutaneous syndromes, associates abnormalities of the cerebellum (rhombencephalosynapsis), cranial nerves (trigeminal anaesthesia), and scalp (alopecia). It has been reported in 11 individuals so far. Other features observed in patients were craniosynostosis, midfacial hypoplasia, bilateral corneal opacities, low-set ears, short stature, moderate intellectual impairment and ataxia. Hyperactivity, depression, self-injurious behaviour and bipolar disorder have also been reported.", + "output": "Cerebellotrigeminal dermal dysplasia (alopecia congenita)" + }, + { + "input": "Definition: Biomedical or Dental Material described as white, water soluable polymer based on acrylamide; used as a thickening or suspending agent in water based formulations.", + "output": "Polyacrylamide (Amide and amide derivative)" + }, + { + "input": "Definition: ASEX-Male Version Questionnaire Question described as arizona Sexual Experiences Scale Male - How easily are you sexually aroused (turned on)?", + "output": "ASEX02-Sexually Aroused (ASEX-Male Version Questionnaire Question)" + }, + { + "input": "Definition: something described as a diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization.", + "output": "Beta-heterochromatin (Cell Component)" + }, + { + "input": "Definition: Cell Function described as the process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium.", + "output": "R8 cell development (Cell Function)" + }, + { + "input": "Definition: Immune System Phenomena described as the sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.", + "output": "complement cascade (activation of immune response)" + }, + { + "input": "Definition: Hair Color described as hypopigmented hair that appears white.", + "output": "hair white (Color of hair - finding)" + }, + { + "input": "Definition: something described as one of three subdivisions of the dentate gyrus in the rat ( Swanson-2004) and the mouse ( Dong-2004 ). The other two are the lateral blade of the dentate gyrus and the crest of the dentate gyrus. Each of these subdivisions consists of the molecular layer of the dentate gyrus, the granular layer of the dentate gyrus, and the polymorphic layer of the dentate gyrus.", + "output": "dentate gyrus, medial blade (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-General Version 4 (FACT-G Version 4) Functional Well-Being: My work (include work at home) is fulfilling.", + "output": "FAC00122 (FACT-G Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Benign neoplasm of esophagus described as a benign adipose tissue neoplasm of the esophagus. Clinical presentation includes obstruction, dysphagia, regurgitation, vomiting and reflux. It may be associated with aspiration and consecutive respiratory infections.", + "output": "Lipoma of the Esophagus (Lipoma)" + }, + { + "input": "Definition: Classification described as this SMQ is a sub-SMQ of Central nervous system vascular disorders (SMQ). For a detailed description, please refer to the one in Central nervous system vascular disorders (SMQ).", + "output": "Conditions associated with central nervous system hemorrhages and cerebrovascular accidents (Classification)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the glutamic acid decarboxylase antibody in a biological specimen.", + "output": "Glutamic Acid Decarboxylase Antibody (Immunologic Tests)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking 1/2 mile (almost 1 km) on flat ground at a normal speed without stopping.", + "output": "FAC10031 (Intellectual Product)" + }, + { + "input": "Definition: Property or Attribute described as the main language that is spoken by the subject most frequently or dominantly.", + "output": "Primary Language Spoken (Property or Attribute)" + }, + { + "input": "Definition: lysosomal transport described as the directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol.", + "output": "transmembrane L-cystine transport from lysosomal lumen to cytosol (vacuolar transmembrane transport)" + }, + { + "input": "Definition: something described as a response indicating that an individual had mild pain or disturbing body sensations, but that they do or did not limit activities.", + "output": "Mild Pain or Disturbing Body Sensations Not Limiting Activities (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the CCL21, chemokine (C-C motif) ligand 21, in a biological specimen.", + "output": "Secondary Lymphoid Tissue Chemokine (Chemokine Measurement)" + }, + { + "input": "Definition: something described as a question about time spent walking or hiking outdoors.", + "output": "Time Spent Walking or Hiking Outdoors (Intellectual Product)" + }, + { + "input": "Definition: Postinfectious neuralgia described as pain that occurs after the disappearance of herpes zoster infection lesions.", + "output": "Postzoster neuralgia (Peripheral Nervous System Infectious Disorder)" + }, + { + "input": "Definition: Immunologic Factor described as an aerosol formulation of aldesleukin, a recombinant form of interleukin-2 (IL-2), with potential immunostimulating activity. Upon IL-2 inhalation, this cytokine activates lymphokine-activated killer cells and natural killer cells, and induces expression of cytotoxic cytokines, such as interferon-gamma and transforming growth factor-beta. This may eventually halt tumor cell growth. Localized administration of IL-2 may decrease toxicity and increase efficacy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101794\" active clinical trials using this agent.", + "output": "aerosolized recombinant IL-2 (Immunologic Factor)" + }, + { + "input": "Definition: Abnormal drug response described as high plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.", + "output": "Elevated plasma drug concentration (Abnormal drug response)" + }, + { + "input": "Definition: Nitrogen-Fixing Bacteria described as a genus of Gram-negative, motile, spirillum-shaped bacteria in the Proteobacteria phylum and Betaproteobacteria class that colonize diverse plants. Many species within Herbaspirillum are able to fix nitrogen. Sugars are oxidized, but not fermented.", + "output": "Herbaspirillum Baldani et al. 1986 emend. Carro et al. 2012 (Bacterium)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as NF-kappa B p105 precursor protein is constitutively processed by the PROTEASOME to produce NF-kappa B p50 subunit. It helps regulate map kinase signaling through its association with Map3k8 protein.", + "output": "NF-kappa B p105 Precursor Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: HADS Questionnaire Question described as hospital Anxiety and Depression Scale - I feel cheerful.", + "output": "HADS01-I Feel Cheerful (Intellectual Product)" + }, + { + "input": "Definition: Dermatitis and Pruitus Agents described as a glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation.", + "output": "Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-,(11beta,16alpha)- (Corticosteroid [EPC])" + }, + { + "input": "Definition: Silurana described as the Western clawed frog, Xenopus tropicalis.", + "output": "Xenopus laevis tropicalis (Amphibian)" + }, + { + "input": "Definition: Gene Mutation described as this gene plays a role in cell survival and the negative regulation of cell growth.", + "output": "CHECKPOINT KINASE 2 (Gene or Genome)" + }, + { + "input": "Definition: something described as this term applies if one or more of the phalanges of the 4th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.", + "output": "Duplication of phalanx of 4th finger (Abnormal 4th finger phalanx morphology)" + }, + { + "input": "Definition: regulation of cell proliferation involved in heart morphogenesis described as any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.", + "output": "regulation of cell proliferation involved in heart valve morphogenesis (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protease-cleavable peptide linked to a fluorescent probe, with potential imaging activity. Upon intravenous infusion of the fluorescent protease-activated peptide AVB-620 before surgery, the peptide moiety of AVB-620 can be cleaved by proteases overexpressed by tumor cells. This activates the fluorescent probe and the tumor cells expressing the proteases can be detected using a fluorescence imaging system. This allows for the visualization and removal of the tumor during surgery.", + "output": "fluorescent protease-activated peptide AVB-620 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Complete duplication of the phalanges of the 2nd finger described as complete duplication of the distal phalanx of index finger.", + "output": "Complete duplication of the outermost bone of the index finger (Complete duplication of the phalanges of the 2nd finger)" + }, + { + "input": "Definition: Cyclin A described as a cyclin A subtype primarily found in male GERM CELLS. It may play a role in the passage of SPERMATOCYTES into meiosis I.", + "output": "Cyclin A1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a cancer vaccine consisting of allogeneic, immortalized dendritic cells (DCs) loaded with tumor specific antigens and activated, with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration of the allogeneic dendritic cell vaccine COMBIG-DC, these activated DCs attract natural killer (NK) cells, induce an anti-inflammatory response leading to the induction of NK-cell-mediated tumor cell death. Upon release of tumor associated antigens (TAAs) from the lysed tumor cells, these antigens are taken up by antigen presenting cells which activate the immune system to elicit a potent cytotoxic T-cell (CTL) response against the TAAs, resulting in the death of TAAs-expressing tumor cells.", + "output": "allogeneic dendritic cell vaccine COMBIG-DC (Immunologic Factor)" + }, + { + "input": "Definition: something described as test codes of questionnaire questions associated with the Expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).", + "output": "Expanded Disability Rating Scale - Postacute Interview Caregiver Version Questionnaire Test Code (Intellectual Product)" + }, + { + "input": "Definition: something described as below the xiphoid.", + "output": "Subxiphoid approach (Procedural approach)" + }, + { + "input": "Definition: negative regulation of nitrogen utilization described as any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle.", + "output": "negative regulation of glutamate metabolic process via glutamine and ammonia (negative regulation of nitrogen utilization)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide.", + "output": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity (2-oxoglutarate-dependent dioxygenase activity)" + }, + { + "input": "Definition: Infusion or Flow Problem described as problem associated with a delivery overdose of therapeutic agents, such as drugs or fluids being delivered into a device or a patient.", + "output": "Overinfusion (Finding)" + }, + { + "input": "Definition: something described as human CSF2RB wild-type allele is located in the vicinity of 22q13.1 and is approximately 17 kb in length. This allele, which encodes cytokine receptor common beta chain protein, is involved in signal transduction. Mutations in the gene that produce variant alleles are associated with the pathogenesis of that myeloproliferative disorder and protein alveolar proteinosis.", + "output": "IL5RB (CSF2RB gene)" + }, + { + "input": "Definition: Bronchi described as a hyaline cartilage in the form of irregular rings in the larger bronchi that changes to small plates and islands in the smaller bronchi.", + "output": "Cartilage of bronchus (Cartilage)" + }, + { + "input": "Definition: Cervical biopsy described as removal of tissue from the ectocervix for microscopic examination.", + "output": "Ectocervical Biopsy (Diagnostic Procedure)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 - Physical Well-Being: I am bothered by side effects of treatment.", + "output": "FAC071-Bothered by Treatment Side Effect (Intellectual Product)" + }, + { + "input": "Definition: something described as diets which become fashionable, but which are not necessarily nutritious.", + "output": "Diet Fads (Diet)" + }, + { + "input": "Definition: Intellectual Product described as baby Eating Behaviour Questionnaire - Concurrent - My baby finds it difficult to manage a complete feed.", + "output": "BEBQ0113 (Intellectual Product)" + }, + { + "input": "Definition: Finding described as a disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.", + "output": "Conjunctivitis, CTCAE (Infections and Infestations, CTCAE)" + }, + { + "input": "Definition: something described as adrenal insufficiency secondary to a defect in ACTH production.", + "output": "ACTH deficient adrenal insufficiency (Disease or Syndrome)" + }, + { + "input": "Definition: Soft tissue lesion described as INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.", + "output": "Inflammation of mouth (Soft tissue lesion)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a human monoclonal antibody directed against the WNT antagonist dickkopf homolog 1 (DKK1), with potential anti-osteolytic activity. Anti-DKK1 monoclonal antibody LY2812176 binds to and inhibits DKK1, thereby restoring signaling through the WNT pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1, overexpressed by myeloma cells, is an inhibitor of the WNT signaling pathway and prevents the mediated formation of bone. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99123\" active clinical trials using this agent.", + "output": "Anti-DKK-1 Monoclonal Antibody LY2812176 (Immunologic Factor)" + }, + { + "input": "Definition: A [Preparations] described as a substance found in the pits of many fruits such as apricots and papayas, and in other foods. It has been tried in some countries as a treatment for cancer, but it has not been shown to work in clinical studies. Amygdalin is not approved for use in the United States.", + "output": "Amygdaloside (Nitriles)" + }, + { + "input": "Definition: Structure of half of brain lateral to midsagittal plane described as the fissure between the gracile lobule and inferior semilunar lobule of the cerebellum", + "output": "Fissura ansoparamediana (Structure of cerebellar fissure)" + }, + { + "input": "Definition: Organic Chemical described as the oil extracted from the seeds of Camellia sinensis. Camellia oil is used in skincare preparations for it anti-oxidant properties. Camellia oil can also be used as a cooking oil.", + "output": "Tea Seed Oil (C [Preparations])" + }, + { + "input": "Definition: something described as catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O.", + "output": "lupeol 28-monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions or duplications of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, located at chromosome 7q31.2, which encodes the protein cystic fibrosis transmembrane conductance regulator. This protein functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. Transport of chloride ions helps control the movement of water in tissues and maintains the fluidity of mucus and other secretions. Genetic variants at this locus have been associated with hereditary pancreatitis, congenital bilateral absence of the vas deferens, cystic fibrosis, and bronchiectasis. Additionally, specific genetic variants have been associated with response to the drugs ivacaftor and lumacaftor in patients in whom cystic fibrosis has been diagnosed.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CFTR (Medical Device)" + }, + { + "input": "Definition: Cell Function described as the orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.", + "output": "chondrocyte intercalation involved in growth plate cartilage morphogenesis (Migration, Cell)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a peptide which has an amino acid sequence that is identical to a portion of a protein that is in the Ras subfamily of small GTPases.", + "output": "Ras Peptide (Immunologic Factor)" + }, + { + "input": "Definition: Body tissue described as tissue and cells derived from nonhuman animals for use in research, as opposed to whole living animals.", + "output": "animal tissue (Tissue)" + }, + { + "input": "Definition: something described as a chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma.", + "output": "chronic inflammatory response to non-antigenic stimulus (chronic inflammatory response)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Child Report (PedsQL Neuromuscular Module Version 3.0 Young Child Report) Think about how you have been doing for the last few weeks. Please listen carefully to each sentence and tell me how much of a problem this is for you: It is hard to use the bathroom.", + "output": "PQL0709 (Intellectual Product)" + }, + { + "input": "Definition: Exotropia described as a type of exotropia (divergent strabismus) in which binocular single vision alternates with large angle exotropia in rhythmic cycle.", + "output": "Cyclic exotropia (Exotropia)" + }, + { + "input": "Definition: purine ribonucleoside binding described as interacting selectively and non-covalently with GMP, guanosine monophosphate.", + "output": "GMP binding (anion binding)" + }, + { + "input": "Definition: Gene or Genome described as human CYP7A1 wild-type allele is located within 8q11-q12 and is approximately 10 kb in length. This allele, which encodes cytochrome P450 7A1 protein, plays a role in the hydroxylation of cholesterol to initiate bile acid synthesis. Functional mutations in the CYP7A1 gene that decrease or abolish the enzymatic activity of the cytochrome P450 7A1 protein are associated with elevated levels of low density lipoprotein.", + "output": "CP7A (Gene or Genome)" + }, + { + "input": "Definition: Surgical Fixation Devices described as a flat, flexible strip of material used to cover or fasten together damaged tissue.", + "output": "Surgical Tape (Surgical Fixation Devices)" + }, + { + "input": "Definition: Finding described as moderate symptoms; intervention indicated", + "output": "Grade 2 Larynx hemorrhage (Laryngeal Hemorrhage, CTCAE)" + }, + { + "input": "Definition: something described as a species of aerobic, Gram-positive, rod shaped bacteria assigned to the phylum Actinobacteria. This species is catalase and urease positive, acid-fast, hydrolyzes esculin but not casein, reduces nitrate, and characteristically produces a mycelium that fragments into bacillary and coccoid elements. N. asteroides is naturally found in soil, ans lake and marine sediment where it digests plant matter; but in humans it is an opportunistic pathogen and one of the causative agents of nocardiosis in immunocompromised individuals.", + "output": "Actinomyces eppinger (Bacterium)" + }, + { + "input": "Definition: Abdominal lymph node group described as a lymph node along the left gastric artery or greater omentum.", + "output": "Gastric Lymph Node (Abdominal lymph node group)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's agreement that they would avoid making a decision about a medical test or treatment if experts had conflicting opinions about it.", + "output": "I would avoid making a decision about a medical test or treatment if experts had conflicting opinions about it (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: DCAF7 gene described as human DCAF7 wild-type allele is located in the vicinity of 17q23.3 and is approximately 44 kb in length. This allele, which encodes DDB1- and CUL4-associated factor 7 protein, may be involved in regulation of transcription.", + "output": "WDR68 (DCAF7 gene)" + }, + { + "input": "Definition: something described as an enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water.", + "output": "Peroxidase, Glutathione (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Miscellaneous Occupation described as the group of professions that include baggage porters, bellhops, and concierges, tour and travel guides, and flight attendants.", + "output": "Transportation, Tourism, and Lodging Attendants (Professional or Occupational Group)" + }, + { + "input": "Definition: Intellectual Product described as a standard terminology developed and maintained by Clinical Data Interchange Standards Consortium (CDISC) and the National Cancer Institute Enterprise Vocabulary Services (NCI-EVS) to support CDISC models, domains and specifications for data representation in regulated research.", + "output": "Clinical Data Interchange Standards Consortium Controlled Terminology (Intellectual Product)" + }, + { + "input": "Definition: something described as a morphologic finding referring to the presence of multiple foci of serpentine necrosis and glial cell perivascular pseudopalisading in a glioma.", + "output": "Multiple Serpentine Pseudopalisading Pattern (Perivascular Pseudopalisading)" + }, + { + "input": "Definition: Dog family described as medium-sized terrestrial carnivores, in the genus Canis, family CANIDAE. Three species are recognized, two found only in Africa and one found in Africa, Europe, and Asia.", + "output": "Jackals (Mammal)" + }, + { + "input": "Definition: Molecular Function described as the incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.", + "output": "cluster assembly (iron-sulfur cluster assembly)" + }, + { + "input": "Definition: Gastrointestinal Disorders, CTCAE described as a disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.", + "output": "Oral Dysesthesia (Finding)" + }, + { + "input": "Definition: Diagnostic Procedure described as the static elastic recoil pressure of the lungs at a given lung volume.", + "output": "Quasi-Static Compliance (Diagnostic Procedure)" + }, + { + "input": "Definition: Cell Component described as a protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.", + "output": "t-UTP complex location (Cell Component)" + }, + { + "input": "Definition: Disease or Syndrome described as an infectious process affecting the small intestine.", + "output": "Small Intestinal Infection (Intestinal infectious disease)" + }, + { + "input": "Definition: Interleukin Receptor described as cell surface receptors that are specific for INTERLEUKIN-1. Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. Signaling from interleukin-1 receptors occurs via interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.", + "output": "Receptor, Interleukin-1 (Immunologic Factor)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of lip and oral cavity cancer, following the rules of the TNM AJCC v7 classification system. The assessment of the primary tumor is based on inspection and palpation of the oral cavity and neck. Additional studies may include CT, MRI, or ultrasound.", + "output": "Lip and Oral Cavity Cancer Clinical TNM Finding v7 (Finding)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Cytomegalovirus described as molecular assay reagents intended to identify Cytomegalovirus (CMV), a DNA virus of the family Herpesviridae, by detecting the deoxyribonucleic acid (DNA) of the target virus. CMV may cause a variety of diseases (e.g., cytomegalic inclusion diseases, leukemia) depending on the immune status and age of the host; persistence of the virus for the lifetime of the host is common.", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Cytomegalovirus, DNA (Medical Device)" + }, + { + "input": "Definition: cell chemotaxis to fibroblast growth factor described as the directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF).", + "output": "endothelial cell chemotaxis to fibroblast growth factor (Cell Function)" + }, + { + "input": "Definition: Plant described as a plant genus of the family URTICACEAE which is the most common cause of pollinosis in Mediterranean countries. It is the source of 'allergen Par o I' and of Pollinex used for DESENSITIZATION, IMMUNOLOGIC.", + "output": "Parietaria L., 1753 (Urticaceae)" + }, + { + "input": "Definition: something described as reagents available as home-test kits that permit the determination of high-density lipoprotein cholesterol (HDL-C) in a sample of whole blood. HDL-C determination kits for home use permit patients to check the level of HDL cholesterol in their blood.", + "output": "IVD Test Reagent/Kits, Home Assay, Whole Blood, Cholesterol, High-Density Lipoprotein (IVD Test Reagent/Kits, Home Assay, Whole Blood, Cholesterol)" + }, + { + "input": "Definition: something described as a posttranscriptional regulation of gene expression that results in regulation of synapse organization.", + "output": "regulation of synapse organisation by posttranscriptional regulation of gene expression (Genetic Function)" + }, + { + "input": "Definition: something described as a chemical pathologist has expertise in the biochemistry of the human body as it applies to the understanding of the cause and progress of disease. This physician functions as a clinical consultant in the diagnosis and treatment of human disease. Chemical pathology entails the application of biochemical data to the detection, confirmation or monitoring of disease.", + "output": "Allopathic & Osteopathic Physicians; Pathology, Chemical Pathology (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as proteins obtained from species of REPTILES.", + "output": "Reptilian Proteins (Proteins)" + }, + { + "input": "Definition: US State described as a state in the northern midwest United States. Its capital is St. Paul.", + "output": "MN (Great Lakes Region)" + }, + { + "input": "Definition: Bladder Neoplasm described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.", + "output": "Stage 0 Bladder Adenocarcinoma AJCC v6 and v7 (Bladder Neoplasm)" + }, + { + "input": "Definition: something described as the numerical identifier of a body weight result in standard units.", + "output": "BWSTRESN (Quantitative Concept)" + }, + { + "input": "Definition: something described as one of four cell groups identified by Nissl stain in the periolivary region of the macaque. The others are the medioventral periolivary nucleus, the superior paraolivary nucleus, and the dorsal periolivary region ( Paxinos-2009a ). It is also identified by some authors in the rat ( Paxinos-2009b ) and the mouse ( Paxinos-2001 ). Functionally it is part of the subcortical auditory system ( Swanson-2004 ).", + "output": "lateroventral periolivary nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Urinalysis described as providing an analysis of a client/patient's urine sample to assess his or her oxidative stress levels. Service is billed per test.", + "output": "Oxidative stress metabolic urinalysis each test (Laboratory Procedure)" + }, + { + "input": "Definition: something described as stage III includes: Any T, N1-3, M0. Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC. There are no clinical subgroups for stage III. N1: Cutaneous melanoma with metastasis in one regional lymph node. N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes. N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s). M0: No detectable evidence of distant metastases.", + "output": "Stage III Lentigo Maligna AJCC v7 (Neoplastic Process)" + }, + { + "input": "Definition: 3-hydroxyacyl-CoA dehydrogenase activity described as catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.", + "output": "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity (3-hydroxyacyl-CoA dehydrogenase activity)" + }, + { + "input": "Definition: Mutation Abnormality described as a mutation occurring in a sequence that regulates non-sense mediated mRNA decay.", + "output": "Non-Sense Mediated Decay Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.", + "output": "D-alanyl-D-alanine carboxypeptidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as physical location of CDH5_Gene", + "output": "16: 64958064-64996190 (Spatial Concept)" + }, + { + "input": "Definition: something described as life-threatening consequences; intubation or urgent intervention indicated", + "output": "Grade 4 Pleura hemorrhage (Pleural Hemorrhage, CTCAE)" + }, + { + "input": "Definition: Disease or Syndrome described as acute Iritis: inflammation of the iris, usually marked by pain, photophobia, constriction of the pupil, and a flair of scleral erythema surrounding the iris. It is best diagnosed by a slit lamp examination. In JRA there may be little discomfort.", + "output": "Acute anterior uveitis or iridocyclitis or hypopyon (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a question about whether an individual plans to take a leave of absence from work over the next year because of their caregiving.", + "output": "Do you plan to take a leave of absence from work over the next year because of your caregiving (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the genetic complement of a microorganism as represented in its DNA or in some microorganisms its RNA.", + "output": "Microbial Genome (Gene or Genome)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway.", + "output": "positive regulation of brassinosteroid mediated signalling (positive regulation of signal transduction)" + }, + { + "input": "Definition: TRANSCRIPTION FACTOR described as thyroid transcription factor 1 (371 aa, ~39 kDa) is encoded by the human NKX2-1 gene. This protein is involved in transcriptional regulation.", + "output": "thyroid transcription factor 1, human (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA.", + "output": "phenylacetyl-CoA:quinone oxidoreductase activity (oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor)" + }, + { + "input": "Definition: Skin or nodule biopsy performed described as subcutaneous Rheumatoid Nodule: a subcutaneous nodule which reveals an irregularly shaped central zone of fibrinoid necrosis surrounded by large mononuclear cells. This core is enveloped by an outer zone of granulation tissue containing lymphocytes and plasma cells.", + "output": "Skin biopsy, subcutaneous RA nodule (Skin finding)" + }, + { + "input": "Definition: something described as a sudden or brief burst of light.", + "output": "Flashers (Visual Manifestations)" + }, + { + "input": "Definition: BCL-2 Gene Family described as the B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.", + "output": "bcl 2 Genes (Proto-Oncogenes)" + }, + { + "input": "Definition: telodendria described as rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.", + "output": "rod telodendria (telodendria)" + }, + { + "input": "Definition: Orientation training described as actions performed to promote the ability to locate oneself in environment", + "output": "reality orientation (Cognitive Therapy)" + }, + { + "input": "Definition: something described as reduced ocular movement of the superior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy.", + "output": "Under-depression in adduction (Finding)" + }, + { + "input": "Definition: something described as poliovirus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to poliovirus in serum. Additionally, some of these reagents consist of poliovirus antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify polioviruses from clinical specimens or from tissue culture isolates derived from clinical specimens. The identification aids in the diagnosis of poliomyelitis (polio) and provides epidemiological information on this disease. Poliomyelitis is an acute infectious disease which in its serious form affects the central nervous system resulting in atrophy (wasting away) of groups of muscles, ending in contraction and permanent deformity.", + "output": "ANTIGENS, CF (INCLUDING CF CONTROL), POLIOVIRUS 1-3 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Non-Small Cell Lung Carcinoma described as lung non-small cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.", + "output": "Advanced Lung Non-Small Cell Carcinoma (Metastatic Lung Non-Small Cell Carcinoma)" + }, + { + "input": "Definition: Impairment in personality functioning described as an abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response.", + "output": "Abnormal fear/anxiety-related behaviour (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as bladder Control Scale test code.", + "output": "QS-BLCS TESTCD (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Genetic Function described as the covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine.", + "output": "charged-tRNA modification (cellular protein modification process)" + }, + { + "input": "Definition: PERSONALITY AND PERSONALITY TRAITS described as an affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.", + "output": "Cyclothymia [Ambiguous] (PERSONALITY AND PERSONALITY TRAITS)" + }, + { + "input": "Definition: something described as serial analysis of gene expression (SAGE) is novel method of assessing the variation in the type or amount of genes expressed in different tissues, at different times in development or in normal versus malignant cells.", + "output": "SAGE Library (Expression Library)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter P described as san qi", + "output": "Pseudoginseng / san qi (Oriental herbs and natural substances letter P)" + }, + { + "input": "Definition: something described as treatment methods or techniques which are based on the knowledge of mind and body interactions. These techniques can be used to reduce the feeling of tension and effect of stress, and to enhance the physiological and psychological well-being of an individual.", + "output": "Therapy, Mind-Body (Complementary therapies)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of rituximab, gemcitabine and oxaliplatin used in the treatment of diffuse large B-cell lymphoma (DLBCL).", + "output": "GEMOX-R (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: regulation of transcription, DNA-templated described as any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V.", + "output": "regulation of transcription from RNA polymerase V promoter (Genetic Function)" + }, + { + "input": "Definition: Defibrillator/Pacemakers described as defibrillators/cardioverters that are permanently inserted (implanted) abdominally, pectorally, or subcutaneously. Pectoral and abdominally implanted devices are connected to the patient's heart through a set of epicardial or transvenous leads. These defibrillators/cardioverters consist of a hermetically sealed container, including a lightweight battery, electronic circuitry to sense cardiac activity and produce the electrical pulses (shocks), and electrode leads that conduct the myocardial signals to the defibrillator and the electrical defibrillating pulses to the patient when needed. Implantable defibrillators/cardioverters are intended to:(1) restore normal rhythm and contractile function in patients who are experiencing ventricular fibrillation or ventricular tachycardia that is not accompanied by a palpable pulse (i.e., defibrillation) or (2) correct noncritical dysrhythmias (e.g., to supraventricular tachycardia, ventricular reentrant tachycardia, atrial flutter and atrial fibrillation) by applying relatively low-level stimuli shocks synchronized to the patient's ECG (i.e., cardioversion). Subcutaneous implanted defibrillator/cardioverters that are connected to leads and electrodes anchored under the skin above but not touching the heart are also available.", + "output": "Implantable Cardioverter Defibrillators (Medical Device)" + }, + { + "input": "Definition: something described as a non-neoplastic disorder that affects the sternum.", + "output": "Non-Neoplastic Sternal Disorder (Non-Neoplastic Chest Wall Disorder)" + }, + { + "input": "Definition: something described as a type of semi-solid pharmaceutical dose form consisting of a large volume of gas dispersed in a liquid or sometimes a solid phase.", + "output": "Aerosol Foam Dosage Form Category (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as acute renal failure (ARF) is characterized by a relatively rapid decline in renal function that leads to the accumulation of water, crystalloid solutes, and nitrogenous metabolites in the body. Other clinical features include: increase in serum creatinine and urea nitrogen levels (azotemia) greater than 0.5 and 10 mg per deciliter, respectively; oliguria; and changes in the rate of urine flow. ARF may present with a de novo onset in individuals whose baseline renal function was within normal limits. Additionally, ARF may consist of acute exacerbation of pre-existing chronic renal insufficiency.", + "output": "Acute renal failure (Classification)" + }, + { + "input": "Definition: Design, Analysis & Interpretation described as the likelihood of the chance occurrence of specific events. May include the mathematical study of probability theory.", + "output": "Probabilities (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process.", + "output": "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process)" + }, + { + "input": "Definition: something described as the relative proportion of subjects to be randomized.", + "output": "randomizationWeight (Conceptual Entity)" + } + ] +} \ No newline at end of file