{ "Contributors": "Disease_Oncology~(DO) authors", "Source": "DO", "URL": "https://github.com/DiseaseOntology/HumanDiseaseOntology", "Reasoning": [], "Input_language": [ "English" ], "Output_language": [ "English" ], "Instruction_language": [ "English" ], "Domains": [ "Medicine", "Clinical Knowledge", "Disease" ], "Positive Examples": [], "Negative Examples": [], "Instances": [ { "input": "infiltrating ureter transitional cell carcinoma", "output": "Infiltrating urothelial carcinoma that affects the renal pelvis and ureter." }, { "input": "familial melanoma", "output": "A melanoma defined by the presence of multiple cases of cutaneous melanoma among blood-relatives on the same side of the family. it is caused by germline mutations in the cdkn2a or cdk4 genes. it is associated with an increased risk of pancreatic cancer in a subset of cdkn2a families (who, 2006)." }, { "input": "adult botryoid rhabdomyosarcoma", "output": "A botryoid rhabdomyosarcoma that is present in an adult." }, { "input": "adult vagina botryoid rhabdomyosarcoma", "output": "A vagina botryoid rhabdomyosarcoma that presents in adulthood." }, { "input": "ethmoid sinus ectopic meningioma", "output": "An extremely rare meningioma that arises as a primary ectopic tumor in the ethmoid sinus." }, { "input": "pineal region teratoma", "output": "A mature or immature teratoma that arises in the pineal region." }, { "input": "pineal region mature teratoma", "output": "A mature teratoma that is located_in the pineal region." }, { "input": "liver carcinoma", "output": "A liver cancer that has_material_basis_in epithelial cells." }, { "input": "oxyphilic endometrial endometrioid adenocarcinoma", "output": "An endometrial adenocarcinoma that is composed predominantly or entirely of large eosinophilic cells." }, { "input": "mediastinal gray zone lymphoma", "output": "A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large b-cell lymphoma and classic hodgkin lymphoma. the identification of this group of lymphomas, along with recent gene expression profiling results (pdl2 gene expression in both mediastinal (thymic) large b-cell lymphoma tissues and hodgkin lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large b-cell lymphomas and classic hodgkin lymphomas are related entities." }, { "input": "mediastinal malignant lymphoma", "output": "A lymphoma that arises from the mediastinum. representative examples include mediastinal (thymic) large b-cell lymphoma and hodgkin lymphoma." }, { "input": "parasagittal meningioma", "output": "A meningioma that affects the falx cerebri." }, { "input": "hepatoblastoma", "output": "Hepatoblastoma" }, { "input": "spinal cord neuroblastoma", "output": "A neuroblastoma that affects the spinal cord." }, { "input": "spinal cord primitive neuroectodermal neoplasm", "output": "A central nervous system embryonal tumor, not otherwise specified arising from the spinal cord." }, { "input": "skin tag", "output": "A reactive cutaneous fibrous lesion that is characterized by a small, painless, flesh colored peduncle arising on the surface of the skin, and develops_from areas of friction, or may be associated with hpv virus, or crohn's disease." }, { "input": "embryonal cancer", "output": "A germ cell cancer that is associated with an embryo." }, { "input": "small bowel fibrosarcoma", "output": "A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel." }, { "input": "ureter small cell carcinoma", "output": "A rare carcinoma that arises from the ureter. it is characterized by the presence of small neuroendocrine cells. the prognosis is poor." }, { "input": "ureter transitional cell carcinoma", "output": "A carcinoma that arises from the transitional epithelium of the ureter. it is associated with tobacco use and usually presents with gross or microscopic hematuria." }, { "input": "ovarian seromucinous carcinoma", "output": "An ovarian carcinoma that is biphasic and has_material_basis_in epithelial and mesenchymal elements." }, { "input": "familiar ovarian carcinoma", "output": "Ovarian carcinoma that has developed in relatives of patients that have a history of ovarian carcinoma." }, { "input": "eye lymphoma", "output": "A lymphoma by site that is manifested in immune system cells called lymphocytes." }, { "input": "glomangiomatosis", "output": "A benign perivascular tumor that is characterized as a vascular variant of a glomus tumor." }, { "input": "predominantly cortical thymoma", "output": "A thymic epithelial neoplasm characterized by the presence of expanded areas which resemble the normal thymic cortex. the neoplastic epithelial cells are small and scant and there is a dense t-lymphocytic component present. areas of medullary differentiation with or without hassall's corpuscles are also present. it may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. it has a low grade malignant potential. the majority of cases occur in the anterior mediastinum as masaoka stage i tumors. a minority of the cases occur as stage ii tumors." }, { "input": "peroneal nerve paralysis", "output": "Lesion of lateral popliteal nerve" }, { "input": "retinal edema", "output": "Retinal edema" }, { "input": "dental enamel hypoplasia", "output": "An acquired or hereditary condition due to deficiency in the formation of tooth enamel (amelogenesis). it is usually characterized by defective, thin, or malformed dental enamel. risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors." }, { "input": "urinary bladder inverted papilloma", "output": "A neoplasm of the bladder in which the epithelial cells grow downward into the underlying supportive tissue, which often causes hematuria." }, { "input": "bladder transitional cell papilloma", "output": "A rare benign condition, characterized by a papillary growth in the urinary tract with a central fibrovascular core. the latter is lined by normal urothelium." }, { "input": "urethra inverted papilloma", "output": "A neoplasm of the urethra in which the epithelial cells grow downward into the underlying supportive tissue." }, { "input": "ureter inverted papilloma", "output": "A neoplasm of the ureter in which the epithelial cells grow downward into the underlying supportive tissue, which often causes hematuria." }, { "input": "ureter urothelial papilloma", "output": "A benign epithelial neoplasm that produces visible warty projections from the epithelial surface of the ureter." }, { "input": "childhood intraocular retinoblastoma", "output": "An intraocular retinoblastoma that effects children." }, { "input": "childhood brain meningioma", "output": "A brain meningioma of childhood that is characterized by brain tumor which develops from the membranes that surround the brain and spinal cord, has_material_basis_in abnormally proliferating cells derives_from meningeal cells of embryonic ectoderm origin." }, { "input": "vulvar inverted follicular keratosis", "output": "An inverted follicular keratosis that is located_in the vulva." }, { "input": "vulvar seborrheic keratosis", "output": "A benign squamous neoplasm that arises from the vulva. it is characterized by the proliferation of the basal cells in the squamous epithelium, acanthosis, hyperkeratosis, and cysts formation." }, { "input": "inverted follicular keratosis", "output": "Seborrheic keratosis that arises from follicular structures in the skin. it presents as a solitary nodule in the skin and is characterized by the presence of prominent squamous eddies." }, { "input": "sphenoidal sinus benign neoplasm", "output": "A benign or malignant neoplasm that affects the sphenoid sinus. representative examples of benign neoplasms include schneiderian papilloma and salivary gland-type adenoma. representative examples of malignant neoplasms include carcinoma and lymphoma." }, { "input": "malignant gastric teratoma", "output": "A malignant teratoma that has_material_basis_in gastric tissue." }, { "input": "combat disorder", "output": "An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress." }, { "input": "telangiectatic osteogenic sarcoma", "output": "An osteosarcoma usually arising from the metaphysis of long bones. it is characterized by the presence of a cystic architecture with blood-filled spaces. the prognosis is similar to that of conventional osteosarcoma." }, { "input": "aleukemic monocytic leukemia cutis", "output": "An aleukemic leukemia cutis that is characterized by infiltration of the skin by neoplastic monocytes." }, { "input": "rectal cloacogenic carcinoma", "output": "A carcinoma that arises from the transitional zone at the junction of the rectum and anus." }, { "input": "bartholin's gland squamous cell carcinoma", "output": "A bartholin's gland carcinoma that derives_from squamous epithelial cells." }, { "input": "acute canaliculitis", "output": "An acute inflammation of lacrimal passage that is characterized by inflammation of the lacrimal caniculi, has_symptom epiphora, has_symptom conjunctivitis, has_symptom eyelid mattering and has_symptom purulent discharge." }, { "input": "acute inflammation of lacrimal passage", "output": "Acute and unspecified inflammation of lacrimal passages" }, { "input": "bladder urothelial papillary carcinoma", "output": "An invasive or non-invasive papillary transitional cell carcinoma of the urinary bladder. it is classified as low - or high-grade. -- 2003" }, { "input": "micropapillary variant infiltrating bladder urothelial carcinoma", "output": "An infiltrating bladder transitional cell carcinoma exhibiting micropapillary growth pattern." }, { "input": "pancreatic cholera", "output": "A rare syndrome characterized by severe watery diarrhea, hypokalemia, and achlorhydria. it is caused by the oversecretion of vasoactive intestinal peptide from the pancreatic islet cells." }, { "input": "dentin sensitivity", "output": "Pain associated with exposed dentin surfaces of the teeth." }, { "input": "peripheral epithelioid sarcoma", "output": "An epithelioid sarcoma involving the extremities. it usually presents as nodular masses in the dermis and subcutaneous tissues or in the tendons and fascia. it frequently recurs and metastasizes to other anatomic sites. the most common sites of metastasis are the lungs, lymph nodes, bones, and brain." }, { "input": "mitochondrial myopathy", "output": "A myopathy that is characterized by mitochondrial dysfunction." }, { "input": "intraocular mixed cell type melanoma", "output": "Uveal melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells." }, { "input": "iris mixed cell melanoma", "output": "Iris melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells." }, { "input": "malignant iris melanoma", "output": "A uveal melanoma that arises from the iris. it is the most common primary malignant neoplasm of the iris. the majority arise in preexisting nevi." }, { "input": "intermediate cell type choroid melanoma", "output": "Choroid melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells." }, { "input": "intermediate cell type ciliary body melanoma", "output": "Ciliary body melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells." }, { "input": "gallbladder mucinous carcinoma", "output": "An adenocarcinoma that arises from the gallbladder. it is characterized by the presence of extracellular mucin that constitutes more than fifty-percent of the tumor." }, { "input": "disease of anatomical entity", "output": "A disease that manifests in a defined anatomical structure." }, { "input": "mitochondrial metabolism disease", "output": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction." }, { "input": "acth-secreting pituitary adenoma", "output": "A functioning pituitary adenoma that characterized by excess cortisol a primary cause of cushing's syndrome." }, { "input": "gemistocytic astrocytoma", "output": "A rare variant of diffuse astrocytoma. it is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. to make the diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (adapted from who)" }, { "input": "childhood cerebral astrocytoma", "output": "An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. the infratentorial location is more common in children." }, { "input": "protoplasmic astrocytoma", "output": "A rare variant of diffuse astrocytoma. it is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant gfap expression. this lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. when occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (adapted from who)" }, { "input": "dentin dysplasia", "output": "A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology." }, { "input": "ovarian mucinous cystadenofibroma", "output": "An ovarian mucinous adenofibroma that is characterized by the presence of cysts or cystic spaces." }, { "input": "infiltrating lipoma", "output": "A benign tumor, composed of lobules of mature adipocytes, that penetrates the surrounding tissue from which it arises. there is usually a higher local recurrence rate when compared with non-infiltrating lipomas." }, { "input": "tendon sheath lipoma", "output": "A synovium neoplasm that is located_in the tendon sheath." }, { "input": "lumbosacral lipoma", "output": "A benign well-circumscribed tumor, composed of lobules of mature adipocytes, that arises within the lumbosacral tissue of the spine." }, { "input": "mucinous intrahepatic cholangiocarcinoma", "output": "An intrahepatic cholangiocarcinoma that produces abundant mucin." }, { "input": "bronchial mucus gland adenoma", "output": "A benign adenomatous neoplasm that arises from the mucous glands in the bronchus." }, { "input": "glottis squamous cell carcinoma", "output": "A squamous cell carcinoma that is located_in the glottis." }, { "input": "bile duct clear cell adenocarcinoma", "output": "A clear cell adenocarcinoma that is located_in the bile duct." }, { "input": "anisakiasis", "output": "A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in anisakis simplex or has_material_basis_in pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung." }, { "input": "childhood immature teratoma of ovary", "output": "An immature teratoma of overy that presents in childhood." }, { "input": "uveal epithelioid cell melanoma", "output": "A uveal melanoma characterized by the presence of malignant large epithelioid melanocytes." }, { "input": "basaloid lung carcinoma", "output": "A large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis." }, { "input": "cervical basaloid squamous cell carcinoma", "output": "A cervical squamous cell carcinoma that is characterized by nests of immature, basal-type squamous cells with scanty cytoplasm." }, { "input": "penis basaloid carcinoma", "output": "An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. it is characterized by the presence of nests of small malignant cells. the malignant cells tend to invade deeply into the adjacent tissues. comedo-type necrosis is often present." }, { "input": "vulvar basaloid squamous cell carcinoma", "output": "A vulva squamous cell carcinoma that is composed of nests of immature, basal-type squamous cells with scanty cytoplasm." }, { "input": "basaloid squamous cell skin carcinoma", "output": "An aggressive variant of skin squamous cell carcinoma characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm." }, { "input": "leber hereditary optic neuropathy", "output": "Hereditary optic atrophy" }, { "input": "thymus basaloid carcinoma", "output": "A rare primary thymic carcinoma, characterized by the presence of tumor cell lobules with peripheral palisading, and a basophilic staining pattern. more than half of reported cases were associated with the presence of a multilocular thymic cyst. metastases to lung and liver have been reported in approximately 30% of cases." }, { "input": "esophageal basaloid squamous cell carcinoma", "output": "A rare morphologic variant of esophageal squamous cell carcinoma. histologically, it is composed of closely packed cells with hyperchromatic nuclei and scant basophilic cytoplasm. it has a similar prognosis to the conventional squamous cell carcinoma of the esophagus. (who)" }, { "input": "multiple skull base meningioma", "output": "Multiple meningiomas that affect the skull base." }, { "input": "mature b-cell neoplasm", "output": "A neoplasm that arises from mature b-lymphocytes or plasma cells. representative examples include mature b-cell non-hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, and plasma cell neoplasms." }, { "input": "b-cell lymphoma", "output": "A non-hodgkin lymphoma that has_material_basis_in b cells." }, { "input": "spinal cord dermoid cyst", "output": "A dermoid cyst that is located_in the spinal cord." }, { "input": "breast lipid-rich carcinoma", "output": "A lipid-rich carcinoma characterized by the presence of cytoplasmic neutral lipids in the vast majority of the malignant cells." }, { "input": "malignant melanocytic peripheral nerve sheath tumor of mediastinum", "output": "A rare variant of malignant peripheral nerve sheath tumor that arises from the mediastinum. it is characterized by the presence of malignant cells that contain melanin." }, { "input": "adult cystic teratoma", "output": "A cystic teratoma that is present in an adult." }, { "input": "lung mixed small cell and squamous cell carcinoma", "output": "A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma." }, { "input": "multicentric papillary thyroid carcinoma", "output": "A papillary carcinoma arising in the thyroid gland from multiple foci." }, { "input": "columnar cell variant papillary carcinoma", "output": "A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells." }, { "input": "tall cell variant papillary carcinoma", "output": "A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns. necrotic changes and high mitotic activity are present." }, { "input": "splenic manifestation of hairy cell leukemia", "output": "Infiltration and expansion of the red pulp of the spleen by hairy cell leukemia." }, { "input": "childhood epithelioid sarcoma", "output": "An epithelioid sarcoma occurring in childhood." }, { "input": "macrocystic pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of collections of thin-walled spaces." }, { "input": "splenic manifestation of leukemia", "output": "A leukemia that is located_in the spleen. it results_in an enlargement of the leukemia." }, { "input": "diaphragma sellae meningioma", "output": "A meningioma that arises from the diaphragma sellae." }, { "input": "epiglottis neoplasm", "output": "A benign or malignant neoplasm that affects the epiglottis." }, { "input": "refractory hairy cell leukemia", "output": "A refractory hematologic cancer that is a mature b cell cancer that does not yield readily to treatment." }, { "input": "refractory hematologic cancer", "output": "A hematologic cancer that is located in the blood or bone marrow that doesn't respond to treatment." }, { "input": "radiation cystitis", "output": "Irradiation cystitis" }, { "input": "hcl-v", "output": "An indolent chronic b-cell leukemia resembling classic hairy cell leukemia but shows variant cytologic, hematologic, and immunophenotypic features and is resistant to the conventional therapy applied to hairy cell leukemia. biologically, it is not related to hairy cell leukemia." }, { "input": "urinary bladder small cell neuroendocrine carcinoma", "output": "A highly aggressive carcinoma, histologically resembling small cell lung carcinoma. in most cases it is associated with carcinoma in situ." }, { "input": "gallbladder small cell carcinoma", "output": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. it is characterized by the presence of malignant small cells." }, { "input": "esophagus small cell carcinoma", "output": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. it is characterized by the presence of malignant small cells." }, { "input": "ampulla of vater small cell carcinoma", "output": "An aggressive neuroendocrine carcinoma arising from the ampulla of vater and the periampullary region. morphologically, it is characterized by the presence of small malignant cells, necrosis, and a high mitotic rate. signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss." }, { "input": "cystitis cystica", "output": "A cysititis that is characterized by hyperplasia of bladder submucosa and cyst formation caused by chronic irritation of the bladder." }, { "input": "endometrial small cell carcinoma", "output": "An small cell carcinoma that has_material_basis_in small cells and located_in the endometrium." }, { "input": "bartholin's gland small cell carcinoma", "output": "A small cell carcinoma that is characterized as an undifferentiated neoplasm composed of primitive-appearing cells and located_in bartholin's gland." }, { "input": "prostate small cell carcinoma", "output": "A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis. it is composed of small cells containing neurosecretory granules." }, { "input": "thymus small cell carcinoma", "output": "An aggressive, small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and numerous apoptotic bodies." }, { "input": "laryngeal small cell carcinoma", "output": "A rare carcinoma that arises from the larynx. it is characterized by the presence of small neuroendocrine cells. it metastasizes early and has an aggressive clinical course." }, { "input": "langerhans cell sarcoma", "output": "A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones." }, { "input": "ankylosing spondylitis", "output": "A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. the disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage." }, { "input": "rheumatoid arthritis", "output": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint." }, { "input": "prostate stromal sarcoma", "output": "A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate." }, { "input": "anaplastic oligodendroglioma", "output": "An oligodendroglioma that is characterized by focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)." }, { "input": "rectal leiomyoma", "output": "A rectal benign neoplasm that has_material_basis_in smooth muscle tissue." }, { "input": "subacute thyroiditis", "output": "Subacute thyroiditis" }, { "input": "thyroiditis", "output": "Thyroiditis" }, { "input": "lung occult adenocarcinoma", "output": "A lung adenocarcinoma detectable by sputum cytology only. the primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed." }, { "input": "lung occult large cell carcinoma", "output": "A large cell lung carcinoma detectable by sputum cytology only. the primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed." }, { "input": "cloacogenic carcinoma", "output": "An anal carcinoma arising from the transitional zone of the anal canal." }, { "input": "anus basaloid carcinoma", "output": "An anal squamous cell carcinoma characterized by the presence of malignant cells with hyperchromatic nuclei and peripheral nuclear palisading." }, { "input": "anal buschke-lowenstein tumor", "output": "A large, well differentiated squamous cell carcinoma with a cauliflower-like appearance, characterized by the presence of an exophytic and endophytic growth pattern. morphologically, there is papillomatosis and acanthosis present, however cytologically the neoplastic squamous cells have a benign appearance. dysplastic changes are minimal. it does not respond to conservative treatment and it is regarded by many authors as an intermediate lesion between condyloma acuminatum and squamous cell carcinoma." }, { "input": "anal canal squamous cell carcinoma", "output": "An anal canal cancer that derives_from epithelial squamous cells." }, { "input": "mixed eosinophil-basophil adenoma", "output": "An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes." }, { "input": "autoimmune hemolytic anemia", "output": "An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies." }, { "input": "benign dermal neurilemmoma", "output": "A benign schwannoma occurring in the skin." }, { "input": "subacute lymphocytic thyroiditis", "output": "Thyroiditis associated with painless enlargement of the thyroid gland. it occurs more frequently in females and is characterized by alterations between hyperthyroidism and hypothyroidism and the eventual return to normal thyroid gland function." }, { "input": "autoimmune thyroiditis", "output": "An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues." }, { "input": "ovarian endometrioid cystadenoma", "output": "An ovarian cystadenoma that is characterized by the presence of endometrial tissue." }, { "input": "hereditary conventional renal cell carcinoma", "output": "A manifestation of von hippel-lindau disease or other familial renal cell cancer syndromes that present as a malignant epithelial neoplasm of the kidney. it is characterized by the presence of lipid-containing clear cells within a vascular network. the tumor usually is bilateral and polycentric, and metastasizes to unusual sites. late metastasis is common." }, { "input": "maxillary sinus adenoid cystic carcinoma", "output": "An adenoid cystic carcinoma that arises from the maxillary sinus. it usually has an aggressive clinical course." }, { "input": "normocytic anemia", "output": "Anemia in which the red blood cell volume is normal." }, { "input": "intermediate malignant teratoma", "output": "A malignant teratoma characterized by the presence of an intermediate amount of undifferentiated tissues." }, { "input": "melanomatosis", "output": "A condition characterized by multiple melanomas." }, { "input": "lung combined large cell neuroendocrine carcinoma", "output": "A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma." }, { "input": "psammomatous meningioma", "output": "A who grade i meningioma characterized by the presence of psammoma bodies that predominate over the meningeal cells." }, { "input": "fibrous meningioma", "output": "A who grade i meningioma characterized by the presence of spindle cells that form bundles in a collagen matrix." }, { "input": "meningothelial meningioma", "output": "A who grade i meningioma characterized by the presence of tumor cells that form lobules. the tumor cells are generally uniform. whorls and psammoma bodies are usually not present." }, { "input": "transitional meningioma", "output": "A who grade i meningioma characterized by the coexistence of meningothelial cells and fibrous architectural patterns." }, { "input": "noninvasive malignant thymoma", "output": "A morphologically malignant thymoma that is entirely confined within the capsule." }, { "input": "gallbladder papillary carcinoma", "output": "A papillary carcioma that is located_in the gallbladder." }, { "input": "breast giant fibroadenoma", "output": "A breast fibroadenoma that is larger than 5 cm." }, { "input": "spinal meninges cancer", "output": "Malignant neoplasm of spinal meninges" }, { "input": "postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma", "output": "A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll) expressing somatic hypermutations of the immunoglobulin heavy chain (igh) genes. the recognition of this variant alters the belief that cll/sll is always derived from a naive, pregerminal center b-cell. the presence of somatic hypermutations of igh genes occurs in approximately 50% of cll/sll cases and implies a postgerminal center, memory origin. patients with this variant of cll/sll have a favorable prognosis, with a reported median survival of more than 24 years." }, { "input": "childhood cns embryonal cell carcinoma", "output": "A central nervous system childhood germ cell tumor characterized by germ cell tumor that develops from embryonic cells that remain in the brain after birth has_material_basis_in abnormally proliferating cells derives_from germ cells." }, { "input": "central nervous system embryonal carcinoma", "output": "A malignant germ cell tumor of the central nervous system composed of large cells that proliferate in cohesive nests and sheets. in rare occasions, tumor cells may replicate the structure of the early embryo, forming \"embryoid bodies\" replete with germ discs and miniature amniotic cavities. additional morphologic characteristics include enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis. (adapted from who)" }, { "input": "adult central nervous system embryonal carcinoma", "output": "A central nervous system adult germ cell tumor that develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has_material_basis_in abnormally proliferating cells derives_from germ cells." }, { "input": "mucinous cystadenocarcinoma of pancreas", "output": "A pancreatic cystadenocarinoma that is characterized by histological characteristics of columnar, mucin-producing epithelium associated with ovarian-type subepithelial stroma, which does not communicate with the pancreatic ductal system, most frequently localized to the body or tail of the pancreas." }, { "input": "pancreatic mucinous cystadenoma", "output": "A non-invasive or invasive cystic epithelial neoplasm that affects almost exclusively females. it is characterized by the presence of columnar mucin-producing epithelial cells and ovarian-type stroma formation." }, { "input": "pancreatic invasive mucinous cystadenocarcinoma", "output": "A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and a focal or extensive invasive carcinomatous component." }, { "input": "female stress incontinence", "output": "The involuntary loss of urine in females secondary to insufficient strength of the pelvic floor muscles; this can result from physical changes following pregnancy and childbirth, or as a response to a decrease in estrogen during menopause." }, { "input": "uterine corpus apoplectic leiomyoma", "output": "An uterine corpus cellular leiomyoma that is characterized by stellate zones of recent hemorrhage within nodules of hypercellular smooth muscle." }, { "input": "uterine corpus cellular leiomyoma", "output": "An uterine benign neoplasm that derives_from smooth muscle cells and that is located_in the uterine corpus." }, { "input": "bladder urachal urothelial carcinoma", "output": "A transitional cell carcinoma of the urinary bladder that arises from the urachal epithelium." }, { "input": "lymphoepithelioma-like acinar prostate adenocarcinoma", "output": "A variant of prostate carcinoma characterized by the presence of malignant cells forming syncytial patterns and dense lymphocytic infiltrates." }, { "input": "selective igd deficiency disease", "output": "A selective immunoglobulin deficiency disease that is characterized by low serum levels of igd immunoglobulins, but is associated with few clinical symptoms." }, { "input": "familiar fallopian tube carcinoma", "output": "Fallopian tube carcinoma that has developed in relatives of patients that have a history of fallopian tube carcinoma." }, { "input": "cribriform variant testicular seminoma", "output": "A morphologic variant of testicular seminoma characterized by the presence of seminoma cells arranged in cribriform patterns and few lymphocytes." }, { "input": "premenstrual tension", "output": "Premenstrual tension syndrome" }, { "input": "nodular episcleritis", "output": "A scleral disease that is characterized by painful inflammation with surface nodule formation of the episcleral tissues that, importantly, spares the sclera itself and has_symptom pain, red eyes, photophobia, tearing, blurry vision, and appearance of eye surface irregularity. nodular episcleritis is typically self-limited and may be caused by vascular congestion within the superficial episcleral plexus." }, { "input": "congenital epulis", "output": "A congenital gingival tumor that occurs along the alveolar ridge of the maxilla. it usually affects female infants. the histogenesis is unknown. morphologically, it is characterized by the presence of large cells with eosinophilic granular cytoplasm. complete surgical resection is curative." }, { "input": "uterine corpus adenocarcinofibroma", "output": "A uterine body mixed cancer that derives_from epithelial cells which originate in glandular tissue and connective tissue." }, { "input": "skene gland carcinoma", "output": "An adenocarcinoma arising in the accessory urethral glands." }, { "input": "endometrial endometrioid adenocarcinoma, secretory variant", "output": "An endometrial adenocarcinoma that is characterized by the presence of confluent, cribriform or villoglandular voluminous glands with glycogen, subnuclear vacuoles (resembles day 17 - 22 endometrium), plus late secretory pattern in uninvolved endometrium." }, { "input": "mucin-rich endometrial endometrioid adenocarcinoma", "output": "An endometrial adenocarcinoma that is characterized by the presence of abundant mucin." }, { "input": "childhood extraosseous osteosarcoma", "output": "An osteosarcoma arising from the soft tissue, and occurring during childhood." }, { "input": "urethral benign neoplasm", "output": "Cancer or tumors of the urethra. benign epithelial tumors of the urethra usually consist of squamous and transitional cells. primary urethral carcinomas are rare and typically of squamous cells. urethral carcinoma is the only urological malignancy that is more common in females than in males." }, { "input": "endodermal sinus pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of connective tissue stalks that contain a blood vessel and are lined by cells with clear cytoplasm and prominent nucleoli." }, { "input": "astroblastoma", "output": "A malignant astrocytoma that is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for gfap), arranged perivascularly." }, { "input": "urinary system benign neoplasm", "output": "An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra." }, { "input": "breast adenomyoepithelial adenosis", "output": "An uncommon variant of breast adenosis characterized by the presence of irregularly shaped glands, epithelial cells with eosinophilic cytoplasm, and prominent myopepithelial cells. mild atypia may be present." }, { "input": "jewett-marshall bladder cancer", "output": "Stage iv includes t4b, no,mo/any t ni, mo/ any t n2 mo,/ any t n3 mo/ any t any n m1 : t4b: tumor invades the pelvic wall, abdominal wall. n1: metastasis in a single lymph node, 2 cm or less in greatest dimension. n2: metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. n3: metastasis in a lymph node more than 5 cm in greatest dimension. m1: distant metastasis." }, { "input": "axonal neuropathy", "output": "Any nerve disorder affecting the axon of a nerve." }, { "input": "urethral disease", "output": "A urinary system disease that is located_in the urethra." }, { "input": "ovarian serous cystadenofibroma", "output": "An ovarian serous adenofibroma that is characterized by the presence of cysts or cystic spaces." }, { "input": "cranial pseudosarcomatous fasciitis", "output": "A rare self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the cranium. this is an osteolytic lesion. it is characterized by the presence of plump spindle-shaped fibroblasts, multinucleated osteoclast-like giant cells, chronic inflammatory infiltrate, red blood cell extravasation, and high mitotic activity." }, { "input": "pseudosarcomatous fibromatosis", "output": "Pseudosarcomatous fibromatosis" }, { "input": "iris spindle cell melanoma", "output": "A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris." }, { "input": "esophageal tuberculosis", "output": "A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. the infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss." }, { "input": "nephrogenic adenoma of urinary bladder", "output": "A metaplastic lesion of the urothelium found in the urinary bladder. it is characterized by the presence of aggregates of cuboidal or hobnail cells and represents a reaction of the urothelium to injury caused by instrumentation, surgery or calculi." }, { "input": "nephrogenic adenoma", "output": "A reactive metaplastic change in the urinary tract epithelium. the metaplastic changes in the epithelium resemble renal tubular structures. it can occur following surgical procedures, inflammation, stone formation, or trauma." }, { "input": "urethra cancer", "output": "An urinary tract cancer that derives_from the tissues of the urethra." }, { "input": "childhood ovarian dysgerminoma", "output": "A childhood ovarian germ cell tumor that derives_from cells that give rise to egg cells." }, { "input": "ovarian stromal hyperthecosis", "output": "An ovarian disease that is characterized by the presence of nests of luteinized theca cells scattered throughout the ovary, which results in severe hyperandrogenism and insulin resistance. clinical symptoms involve slowly progressive acne, hirsutism, virilization." }, { "input": "thymic dysplasia", "output": "The developmental arrest and architectural distortion of the thymus that results in immunodeficiency." }, { "input": "rectum sarcomatoid carcinoma", "output": "A biphasic rectal carcinoma with a spindle cell, sarcomatoid component." }, { "input": "male urethral cancer", "output": "A primary or metastatic malignant neoplasm that affects the male urethra." }, { "input": "solid pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of aggregates of polygonal malignant cells with clear cytoplasm and prominent nucleoli." }, { "input": "vulvar keratinizing squamous cell carcinoma", "output": "A vulva squamous cell carcinoma that is characterized by keratin pearls, abundant keratohyaline granules or dense cytoplasmic keratinization." }, { "input": "kimura disease", "output": "A chronic, benign, inflammatory condition that is characterized by the swelling of lymph node in the head and neck." }, { "input": "superficial urinary bladder cancer", "output": "A carcinoma of bladder that originates in the epithelial cells (the internal lining) of the bladder wall and is limited to this area." }, { "input": "pituitary hypoplasia", "output": "Incomplete development of the pituitary gland." }, { "input": "adrenal medulla carcinoma", "output": "An adrenal medulla cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, { "input": "female urethral cancer", "output": "A primary or metastatic malignant neoplasm that affects the female urethra." }, { "input": "pulmonary vein leiomyosarcoma", "output": "A leiomyosarcoma that is located_in the pulmonary vein." }, { "input": "pulmonary artery leiomyosarcoma", "output": "A leiomyosarcoma that is located_in the pulmonary artery." }, { "input": "superior vena cava leiomyosarcoma", "output": "A leiomyosarcoma that is located_in the superior vena cava." }, { "input": "cerebral primitive neuroectodermal tumor", "output": "A central nervous system embryonal tumor, not otherwise specified arising from the cerebral hemispheres." }, { "input": "hematopoietic system disease", "output": "A disease of anatomical entity that has_material_basis_in hematopoietic cells." }, { "input": "nijmegen breakage syndrome", "output": "A syndrome characterized by chromosomal instability, microcephaly, growth retardation, immunodeficiency, cellular hypersensitivity to x-rays, and predisposition to cancer that has_material_basis_in homozygous or compound heterozygous mutation in nbn on chromosome 8q21.3." }, { "input": "colonic l-cell glucagon-like peptide producing tumor", "output": "A neuroendocrine tumor that arises from the colon and produces glucagon-like peptides. morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns." }, { "input": "l-cell glucagon-like peptide producing tumor", "output": "A neuroendocrine tumor that arises from the gastrointestinal tract and produces glucagon-like peptides. morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns." }, { "input": "vulvar keratoacanthoma", "output": "A vulva squamous cell carcinoma that is rapidly growing, self-limited, and characterized by the presence of a central crater that contains squamous cells. the proliferating squamous cells infiltrate the dermis below and produce keratin masses that are pushed towards the surface of the tumor. it is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior." }, { "input": "vulvar non-keratinizing squamous cell carcinoma", "output": "A vulva squamous cell carcinoma that is composed of polygonal squamous cells growing in sheets or nests that may have intercellular bridges, but keratin pearls are not present." }, { "input": "ovarian endometrioid cystadenofibroma", "output": "An ovarian endometrioid adenofibroma that is characterized by the presence of cysts and/ or cystic spaces." }, { "input": "cutaneous anthrax", "output": "An anthrax disease that results_in infection located_in skin, has_material_basis_in bacillus anthracis, which is transmitted_by contact with infected animals or animal products. the infection has_symptom skin lesion that eventually forms an ulcer with a black center." }, { "input": "anthrax disease", "output": "A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath." }, { "input": "pineal region germinoma", "output": "A type of germ cell tumor that is found in the pineal gland in the brain. symptoms of pineal germinomas include headaches, changes in vision, nausea, and vomiting." }, { "input": "childhood brain germinoma", "output": "A brain germinoma that is characterized by tumor of the germ cell in childhood that has_material_basis_in abnormally proliferating cells derives_from germ cells, located_in pineal area and located_in suprasellar area." }, { "input": "dermatographia", "output": "A physical urticaria induced by stroking of the skin." }, { "input": "childhood germ cell brain tumor", "output": "A central nervous system childhood germ cell tumor that is characterized by germ cell tumor, that develops from embryonic cells that remain in the brain after birth has_material_basis_in abnormally proliferating cells derives_from germ cells." }, { "input": "polyvesicular vitelline pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of collections of vesicles that are surrounded by connective tissue." }, { "input": "sarcomatoid uterine corpus endometrioid adenocarcinoma", "output": "An endometrial adenocarcinoma that has_material_basis_in mesenchymal elements." }, { "input": "uterus perivascular epithelioid cell tumor", "output": "A perivascular epithelioid cell tumor that is located_in the uterus." }, { "input": "ovarian clear cell cystadenocarcinoma", "output": "An ovarian cystadenocarcinoma that is characterized by the presence of cells with clear cytoplasm." }, { "input": "polyp of middle ear", "output": "Polyp of middle ear" }, { "input": "monoclonal gammopathy of uncertain significance", "output": "A blood protein disease that is characterized by the presence of an abnormal protein called monoclonal protein in the blood." }, { "input": "epididymis adenomatoid tumor", "output": "A male reproductive organ benign neoplasm that is located_in the epididymis." }, { "input": "enterobiasis", "output": "A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm enterobius vermicularis. the major symptom is perianal itching. infected people experience perianal pruritus and excoriations from scratching." }, { "input": "acantholytic variant squamous cell breast carcinoma", "output": "A breast squamous cell carcinoma that is characterized by lack of cohesiveness of the tumour cells resulting in a pseudovascular or pseudoglandular appearance." }, { "input": "adenomatoid tumor", "output": "Benign neoplasm of mesothelial tissue, unspecified" }, { "input": "spindle cell variant squamous cell breast carcinoma", "output": "A breast squamous cell carcinoma that is characterized by the presence of spindle-shaped malignant cells and arises from the breast parenchyma." }, { "input": "large cell keratinizing variant squamous cell breast carcinoma", "output": "A breast squamous cell carcinoma characterized by large epithelial cells that contain keratin." }, { "input": "childhood pleomorphic rhabdomyosarcoma", "output": "A rare aggressive rhabdomyosarcoma occurring in children. the neoplasm is characterized by the presence of bizarre round, spindle, and polygonal cells." }, { "input": "chronic nk-cell lymphocytosis", "output": "A hypersensitivity reaction type iv disease that is characterized by absolute lymphocytosis of natural killer (cd3- cd16+) cells often with concurrent cytopenia and has_symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy." }, { "input": "malignant pleural mesothelioma", "output": "A pleural cancer that has_material_basis_in mesothelium cells." }, { "input": "diverticulitis", "output": "An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall." }, { "input": "duodenal somatostatinoma", "output": "A somatostatin-producing neuroendocrine tumor that arises from the duodenum. it is characterized by the presence of tubulo-glandular structures." }, { "input": "large cell carcinoma with rhabdoid phenotype", "output": "A large cell lung carcinoma characterized by the presence of rhabdoid cells." }, { "input": "petrous apex meningioma", "output": "A meningioma that affects the petrous apex." }, { "input": "cervical keratinizing squamous cell carcinoma", "output": "A cervical squamous cell carcinoma that is characterized by keratin pearls, abundant keratohyaline granules or dense cytoplasmic keratinization." }, { "input": "posterior urethra cancer", "output": "A female urethral cancer located_in the posterior urethra." }, { "input": "osgood-schlatter's disease", "output": "A bone inflammation disease that involves rupture of the growth plate in children located_in tibia." }, { "input": "vulvar proximal-type epithelioid sarcoma", "output": "An epithelioid sarcoma of the proximal type involving the vulva." }, { "input": "central epithelioid sarcoma", "output": "An epithelioid sarcoma predominantly involving the pelvis, perineum, and genital organs. it tends to have a more aggressive clinical course as compared to the more frequently seen distal-type epithelioid sarcoma." }, { "input": "brain ependymoma", "output": "A brain glioma that is characterized by tumor of the ependyma, has_material_basis_in abnormally proliferating cells derives_from ependymal cells, located_in spine in adults and located_in intracranial (4th ventricle) in children." }, { "input": "lymphatic system disease", "output": "An immune system disease that is located_in the lymphatic system." }, { "input": "peptic ulcer disease", "output": "Peptic ulcer, site unspecified" }, { "input": "childhood infratentorial ependymoma", "output": "An ependymoma that arises from the infratentorial region of the brain and occurs during childhood." }, { "input": "childhood supratentorial ependymoma", "output": "An ependymoma that arises from the supratentorial region of the brain and occurs during childhood." }, { "input": "extrahepatic bile duct papillary adenoma", "output": "An extrahepatic bile duct adenoma that is located_in the extrahepatic bile duct." }, { "input": "small intestine benign neoplasm", "output": "A benign or malignant neoplasm that affects the small intestine. representative examples of benign neoplasms include lipoma and leiomyoma. representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma." }, { "input": "small intestinal l-cell glucagon-like peptide producing tumor", "output": "A neuroendocrine tumor that arises from the small intestine and produces glucagon-like peptides. morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns." }, { "input": "breast intraductal papillomatosis", "output": "A benign breast neoplasm characterized by the presence of multiple intraductal papillomas." }, { "input": "wolffian adnexal neoplasm", "output": "A benign or malignant epithelial neoplasm of probable wolffian origin. it predominantly arises from the broad ligament and presents as a unilateral adnexal mass." }, { "input": "lumbar spinal canal and spinal cord meningioma", "output": "A meningioma that arises from the meninges of the lumbar region of the spinal cord." }, { "input": "childhood central nervous system mixed germ cell tumor", "output": "A central nervous system germ cell tumor of childhood that is characterized by mixed germ cell tumor, develops from embryonic cells that remain in the brain after birth has_material_basis_in abnormally proliferating cells derives_from germ cells." }, { "input": "inhibited female orgasm", "output": "Female orgasmic disorder" }, { "input": "endocervical carcinoma", "output": "A cervix carcinoma that is located_in the endocervix." }, { "input": "peptic ulcer perforation", "output": "Penetration of a peptic ulcer through the wall of duodenum or stomach allowing the leakage of luminal contents into the peritoneal cavity." }, { "input": "periductal breast myoepitheliosis", "output": "A breast myoepitheliosis that is characterized by multifocal, often microscopic proliferation of myoepithelial cells around small ducts." }, { "input": "breast myoepitheliosis", "output": "A breast myoepithelial neoplasm that is characterized by multifocal, often microscopic proliferation of myoepithelial cells in or around small ducts." }, { "input": "childhood infratentorial embryonal tumor with multilayered rosettes, c19mc-altered", "output": "A childhood embryonal tumor with multilayered rosettes, c19mc-altered that arises from the infratentorial region and occurs in children." }, { "input": "acute gonococcal endometritis", "output": "An acute endometritis that is caused by gonorrhea." }, { "input": "acute endometritis", "output": "An endometritis that is characterized by onset within the past 1 - 3 days." }, { "input": "anal gland adenocarcinoma", "output": "An anus carcinoma that derives_from epithelial cells of glandular origin located_in the anal gland." }, { "input": "squamous papillomatosis", "output": "A benign squamous neoplasm characterized by a papillary growth pattern, diffusely involving a specific anatomic site." }, { "input": "breast cystic hypersecretory carcinoma", "output": "A breast secretory carcinoma that is characterized by numerous cysts of varying sizes containing gelatinous material on gross examination, microscopically dilated ducts containing eosinophilic secretion and the absence of micropapillary pattern and cytological atypia in the lining epithelium." }, { "input": "breast ductal adenoma", "output": "A breast adenoma that is characterized by a prominent fibrotic capsule and a bilayered tubular component." }, { "input": "pregnancy adenoma", "output": "A breast adenoma that occurs during pregnancy." }, { "input": "bladder tuberculosis", "output": "An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles." }, { "input": "breast apocrine adenoma", "output": "A breast adenoma that is characterized by apocine differentiation." }, { "input": "mixed epithelial/mesenchymal metaplastic breast carcinoma", "output": "A breast metaplastic carcinoma that is characterized by the presence of epithelial and mesenchymal components." }, { "input": "ceruminoma", "output": "A tumor (abnormal growth of tissue) of the ceruminal gland. [hpo:probinson]" }, { "input": "gonorrhea", "output": "A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. the infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods." }, { "input": "infiltrating bladder urothelial carcinoma sarcomatoid variant", "output": "An invasive transitional cell carcinoma of the bladder that exhibits spindle cell sarcomatoid features." }, { "input": "vulvar eccrine porocarcinoma", "output": "A vulva carcinoma that is characterized by heterogenous histology that includes squamous cells, mucinous cells, clear cells, pigmented cells, and spindle cells and derives_from eccrine sweat glands." }, { "input": "eccrine porocarcinoma", "output": "A rare malignant neoplasm of the sweat glands. it most often develops as a form of degenerative progression from a benign eccrine poroma." }, { "input": "vulvar clear cell hidradenocarcinoma", "output": "A vulva carcinoma that derives_from sweat glands and is characterized by the presence of clear cells." }, { "input": "pancreatic intraductal papillary-colloid carcinoma", "output": "A malignant glandular neoplasm arising from the exocrine pancreas. microscopically it is characterized by the presence of mucoid stroma formation, papillary patterns, and cystic changes. it has been associated with kras and tp53 gene mutations." }, { "input": "pancreatic intraductal papillary-mucinous neoplasm", "output": "A pancreatic cancer that is characterized as a slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts." }, { "input": "pancreatic foamy gland adenocarcinoma", "output": "A pancreatic ductal adenocarcinoma characterized by the presence of adenocarcinoma cells with foamy cytoplasm." }, { "input": "breast scirrhous carcinoma", "output": "A breast carcinoma that is characterized by the presence of hard, fibrous, particularly invasive tumors in which the malignant cells occur singly or in small clusters or strands in dense connective tissue." }, { "input": "situs inversus", "output": "A visceral heterotaxy that is characterized by complete right-to-left reversal of the position of the major thoracic and abdominal organs." }, { "input": "glottis verrucous carcinoma", "output": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the glottic area of the larynx. it usually presents with hoarseness." }, { "input": "subglottis verrucous carcinoma", "output": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the subglottic area of the larynx." }, { "input": "subglottis squamous cell carcinoma", "output": "A squamous cell carcinoma of the larynx that arises from the subglottic area. symptoms include dyspnea and stridor. it spreads to the hypopharynx, trachea, and thyroid gland." }, { "input": "supraglottis verrucous carcinoma", "output": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the supraglottic area of the larynx." }, { "input": "supraglottis squamous cell carcinoma", "output": "A squamous cell carcinoma of the larynx that arises from the supraglottic area. signs and symptoms include dysphagia, a sensation of foreign body in the throat, and hemoptysis. it spreads to the space anterior to the epiglottis, pyriform sinus, and base of the tongue." }, { "input": "gestational ovarian choriocarcinoma", "output": "A choriocarcinoma of the ovary that develops in the presence of a preceding gestational event." }, { "input": "asbestos-related lung carcinoma", "output": "A carcinoma arising in the lung due to exposure to asbestos." }, { "input": "cervical lymphoepithelioma-like carcinoma", "output": "A cervical squamous cell carcinoma that is characterized by poorly defined islands of undifferentiated squamous cells in a background intensely infi ltrated by lymphocytes. the tumour cells have uniform, vesicular nuclei with prominent nucleoli and moderate amounts of slightly eosinophilic cytoplasm. the cell borders are indistinct." }, { "input": "lymphoepithelioma-like thymic carcinoma", "output": "A rare, usually aggressive primary thymic carcinoma, characterized by a syncytial growth of undifferentiated carcinoma cells and the presence of a lymphoplasmacytic infiltrate. more than 40% of cases are associated with epstein-barr virus infection." }, { "input": "stomach disease", "output": "A gastrointestinal system disease that is located_in the stomach." }, { "input": "infiltrating bladder lymphoepithelioma-like carcinoma", "output": "Infiltrating carcinoma with lymphoepithelioma-like features that affects the bladder." }, { "input": "conventional osteosarcoma", "output": "A bone osteosarcoma that is characterized by the presence of osteoid extracellular matrix and that arises from the medullary portion of the bone. it affects the long bones and most commonly, the distal femur, proximal tibia, and proximal humerus. pain with or without a palpable mass is the most common clinical presentation." }, { "input": "fibrosarcomatous osteosarcoma", "output": "A conventional osteosarcoma characterized by the presence of spindle shaped cells." }, { "input": "chief cell adenoma", "output": "A parathyroid gland adenoma composed predominantly of neoplastic chief cells. these cells have either slightly eosinophilic or vacuolated cytoplasm, and round nuclei." }, { "input": "parathyroid adenoma", "output": "A parathyroid gland benign neoplam that is located_in the parathyroid." }, { "input": "parathyroid transitional clear cell adenoma", "output": "A parathyroid gland adenoma composed predominantly of neoplastic cells with clear cytoplasm." }, { "input": "mixed cell type adenoma of parathyroid", "output": "A parathyroid gland adenoma that contains a mixture of neoplastic cells (chief cells, oncocytes, and clear cells)." }, { "input": "parathyroid oncocytic adenoma", "output": "A parathyroid gland adenoma composed predominantly or entirely of neoplastic cells with abundant granular eosinophilic cytoplasm." }, { "input": "childhood intracortical osteosarcoma", "output": "A high grade malignant bone-forming mesenchymal neoplasm that produces osteoid and occurs in childhood. it arises from the medullary portion of the bone. it affects the long bones, and most commonly, the distal femur, proximal tibia, and proximal humerus. pain with or without a palpable mass is the most common clinical presentation. it usually has an aggressive growth and may metastasize through the hematogenous route. the lung is the most frequent site of metastasis." }, { "input": "sarcomatosis of the meninges", "output": "A rare condition characterized by diffuse spread of sarcoma cells throughout the meninges. the neoplastic cells are derived from meningeal connective tissue. clinically, this disorder may present as a fulminant pachymeningitis and/or encephalitis." }, { "input": "meninges sarcoma", "output": "A rare sarcoma arising from the meninges." }, { "input": "sarcomatosis", "output": "A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body." }, { "input": "adult embryonal tumor with multilayered rosettes, c19mc-altered", "output": "An embryonal tumor with multilayered rosettes, c19mc-altered, occurring in adults." }, { "input": "cowper gland carcinoma", "output": "A male reproductive organ cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is_located_in the cowper's gland." }, { "input": "macular holes", "output": "A hole in the macula of the retina." }, { "input": "suprasellar meningioma", "output": "A meningioma that arises from the suprasellar region." }, { "input": "gasserian ganglion meningioma", "output": "A meningioma that affects the trigeminal ganglion." }, { "input": "malignant granular cell skin tumor", "output": "A malignant granular cell tumor that arises from the skin." }, { "input": "cholangiolocellular carcinoma", "output": "An intrahepatic cholangiocarcinoma that arises from the canals of hering." }, { "input": "acantholytic squamous cell skin carcinoma", "output": "A histologic variant of squamous cell carcinoma that arises from the skin. it is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis." }, { "input": "multiple spinal canal and spinal cord meningioma", "output": "Multiple meningiomas that arises from the spinal meninges." }, { "input": "pulmonary type ovarian small cell carcinoma", "output": "An ovarian small cell carcinoma that resembles pulmonary small cell carcinoma of neuroendocrine type." }, { "input": "small-cell carcinoma of the ovary of hypercalcemic type", "output": "An ovarian small cell carcinoma that is associated with paraneoplastic hypercalcemia." }, { "input": "adult infiltrating astrocytic neoplasm", "output": "An infiltrating astrocytic tumor of the brain occurring in adults." }, { "input": "endometrial mixed adenocarcinoma", "output": "An endometrial adenocarcinoma that is composed of both type i (endometrioid) and type ii (serous or clear cell type) tumors, with at least 10% of each component." }, { "input": "non-gestational ovarian choriocarcinoma", "output": "An ovarian primitive germ cell tumor that has_material_basis_in trophoblastic cells and develops in the absence of a preceding gestational event." }, { "input": "muscular atrophy", "output": "Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation." }, { "input": "testicular fibroma", "output": "A benign neoplasm that arises from the testis and is characterized by the presence of fusiform cells and collagenization." }, { "input": "testicular thecoma", "output": "A rare benign tumor that arises from the testis and is characterized by the presence of lipid-rich neoplastic spindle cells." }, { "input": "sphenoid sinus inverted papilloma", "output": "A benign neoplasm that arises from the ciliated respiratory mucosa that lines the sphenoid sinus. it results from the invagination and proliferation of epithelial cells in the underlying stroma." }, { "input": "sphenoid sinus schneiderian papilloma", "output": "A papilloma that arises from the ciliated respiratory mucosa that lines the sphenoid sinus. it is classified as inverted papilloma and oncocytic papilloma." }, { "input": "retinoblastoma", "output": "A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina." }, { "input": "maxillary sinus adenocarcinoma", "output": "An adenocarcinoma that arises from the maxillary sinus." }, { "input": "pancreatic non-invasive intraductal papillary-mucinous carcinoma", "output": "A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit loss of polarity, nuclear stratification, hyperchromasia, and pleomorphism. there is severe architectural atypia and frequent mitotic figures present." }, { "input": "leptomeninges sarcoma", "output": "A sarcoma arising from the leptomeninges." }, { "input": "neuroblastoma", "output": "An autonomic nervous system neoplasm that derives_from immature nerve cells." }, { "input": "abdominal aortic aneurysm", "output": "An aortic aneurysm that is located_in the abdominal aorta." }, { "input": "bladder urachal adenocarcinoma", "output": "A rare bladder adenocarcinoma that develops from the urachal remnant." }, { "input": "pancreatic acth hormone producing tumor", "output": "A malignant, ectopic acth secreting pancreatic neuroendocrine tumor, associated with cushing syndrome. the prognosis is usually poor." }, { "input": "non-functioning pancreatic endocrine tumor", "output": "A low or intermediate grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. it is characterized by the absence of a hormone-related clinical syndrome." }, { "input": "gastrointestinal system disease", "output": "A disease of anatomical entity that is located_in the gastrointestinal tract." }, { "input": "rectum signet ring adenocarcinoma", "output": "An infiltrating adenocarcinoma arising from the rectum. it is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. these cells constitute more than 50% of the malignant cellular population." }, { "input": "perianal skin paget's disease", "output": "Paget disease involving the perianal skin." }, { "input": "retinal cell cancer", "output": "A malignant neoplasm that derives_from the retina." }, { "input": "tuberculum sellae meningioma", "output": "A meningioma that arises from the tuberculum sellae." }, { "input": "colloid carcinoma of the pancreas", "output": "An infiltrating pancreatic ductal adenocarcinoma, characterized by the presence of malignant cells floating in pools of mucin. it has a more favorable prognosis than the conventional infiltrating ductal adenocarcinoma. it often arises in association with intraductal pancreatic mucinous neoplasms and in some cases it may result in the development of pseudomyxoma peritonei." }, { "input": "epilepsy with generalized tonic-clonic seizures", "output": "An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type." }, { "input": "acinar cell cystadenocarcinoma", "output": "A cystic adenocarcinoma characterized by the presence of relatively uniform neoplastic cells which produce pancreatic enzymes and are arranged in acinar patterns. signs and symptoms include abdominal pain, weight loss, nausea, and diarrhea. it usually has an aggressive clinical course." }, { "input": "childhood malignant hemangiopericytoma", "output": "A malignant hemangiopericytoma occurring in childhood." }, { "input": "childhood malignant schwannoma", "output": "A malignant peripheral nerve sheath tumor occurring in children." }, { "input": "signet ring cell intrahepatic cholangiocarcinoma", "output": "An intrahepatic cholangiocarcinoma characterized by the presence of signet ring adenocarcinoma cells." }, { "input": "pancreatic colloid cystadenoma", "output": "A non-metastasizing cystic epithelial neoplasm arising from the exocrine pancreas. it is composed of columnar, mucin-producing epithelial cells. it occurs almost exclusively in women. large tumors are often accompanied by a palpable abdominal mass." }, { "input": "retinal telangiectasia", "output": "Dilatation of small blood vessels of the retina. [hpo:probinson]" }, { "input": "retina lymphoma", "output": "A lymphoma arising from the retina." }, { "input": "childhood extraocular retinoblastoma", "output": "An extraocular retinoblastoma that effects children." }, { "input": "intraocular lymphoma", "output": "A form of malignant cancer which occurs within the eyeball." }, { "input": "adult brain ependymoma", "output": "A brain ependymoma that is characterized by tumor in the ependyma of adults located_in spine, located_in intracranial (4th ventricle) and has_material_basis_in abnormally proliferating cells derives_from ependymal cells." }, { "input": "extrahepatic biliary papillomatosis", "output": "A biliary papillomatosis located_in an extrahepatic bile duct." }, { "input": "neonatal leukemia", "output": "A childhood leukemia that occurs during the neonatal period." }, { "input": "childhood leukemia", "output": "A leukemia that occurs in children." }, { "input": "childhood multilocular cystic kidney neoplasm", "output": "A kidney benign neoplasm that encompasses cystic nephroma and cystic partially differentiated nephroblastoma." }, { "input": "carcinoma of supraglottis", "output": "A carcinoma of the larynx that arises from the supraglottic area." }, { "input": "subglottis carcinoma", "output": "A carcinoma of the larynx that arises from the subglottic area." }, { "input": "coats disease", "output": "Exudative retinopathy" }, { "input": "delusional disorder", "output": "A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect." }, { "input": "breast osteosarcoma", "output": "A breast sarcoma that arises from bone." }, { "input": "adult spinal cord ependymoma", "output": "An ependymoma of the spinal cord occurring in adults." }, { "input": "placenta disease", "output": "A uterine disease that is located_in the placenta." }, { "input": "adult spinal cord glioblastoma multiforme", "output": "A rare spinal tumor which is highly malignant and tends to be locally invasive of surrounding neural tissue. the tumor also tends to spread throughout the neuroaxis and is often rapidly progressive. histologically the tumors are highly cellular with nuclear and cellular pleomorphism, endothelial proliferation, mitotic figures, and, often, necrosis. this tumor has a relatively poor prognosis. clinical features may include pain followed by rapidly progressive neurologic deficits such as extremity weakness, sensory changes, spasticity, and incontinence. (from innocenzi et al., clin neurol neurosurg 1997 feb;99(1):1-5)" }, { "input": "necrotic uveal melanoma", "output": "An uveal melanoma characterized by the presence of tumor cell necrosis." }, { "input": "mixed astrocytoma-ependymoma-oligodendroglioma", "output": "A mixed glioma characterized by the presence of astrocytic, ependymal, and oligodendroglial neoplastic components." }, { "input": "petroclival meningioma", "output": "A meningioma that affects the petroclival region." }, { "input": "sphenoorbital meningioma", "output": "A meningioma that affects the sphenoorbital region." }, { "input": "renal infectious disease", "output": "Renal tubulo-interstitial disease, unspecified" }, { "input": "sphenocavernous meningioma", "output": "A meningioma that affects the sphenocavernous region." }, { "input": "spinal multifocal clear cell meningioma", "output": "A clear cell meningioma arising in multiple areas of the spinal cord characterized by the presence of clear glycogen-rich polygonal cells." }, { "input": "adult papillary meningioma", "output": "A papillary meningioma occurring in adults." }, { "input": "adult extraosseous osteosarcoma", "output": "An osteosarcoma that is located_in the soft tissues without direct attachment to the skeletal system and results in the production of osteoid, bone, or chondroid material." }, { "input": "end stage renal disease", "output": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease." }, { "input": "infiltrating nipple syringomatous adenoma", "output": "A nipple benign neoplasm that is characterized a as locally infiltrative nonmetastasizing tumor of the nipple." }, { "input": "chronic kidney disease", "output": "A kidney failure that is characterized by the gradual loss of kidney function." }, { "input": "pancreatic non-functioning delta cell tumor", "output": "A usually malignant neuroendocrine tumor arising from the delta cells of the pancreas. it is not associated with a hormonal syndrome." }, { "input": "childhood embryonal tumor with multilayered rosettes, c19mc-altered", "output": "An embryonal tumor with multilayered rosettes, c19mc-altered that occurs during childhood." }, { "input": "female breast carcinoma", "output": "A breast carcinoma that is manifested in the female breast." }, { "input": "interdigitating dendritic cell sarcoma", "output": "A histiocytic and dendritic cell cancer that effect dendritic cells." }, { "input": "dendritic cell sarcoma", "output": "A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes." }, { "input": "laryngeal disease", "output": "Fracture of other parts of neck" }, { "input": "maxillary sinus inverted papilloma", "output": "A benign neoplasm that arises from the ciliated respiratory mucosa that lines the maxillary sinus. it results from the invagination and proliferation of epithelial cells in the underlying stroma." }, { "input": "adult xanthogranuloma", "output": "A xanthogranuloma that occurs in adults." }, { "input": "uterine corpus atypical polypoid adenomyoma", "output": "An atypical polypoid adenomyoma that is located_in the uterine corpus." }, { "input": "luteoma", "output": "An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium." }, { "input": "mite infestation", "output": "A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family sarcoptidae, trombiculidae and demodicidae." }, { "input": "ocular hypotension", "output": "Hypotony of eye" }, { "input": "adult extraskeletal myxoid chondrosarcoma", "output": "An extraskeletal myxoid chondrosarcoma occurring in adults." }, { "input": "intracranial chondrosarcoma", "output": "An extraskeletal myxoid chondrosarcoma arising from the structures within the cranium." }, { "input": "mixed astrocytoma-ependymoma", "output": "A tumor of mixed cell type with astrocytic components as well as ependymoma components." }, { "input": "maxillary sinus squamous cell carcinoma", "output": "A squamous cell carcinoma that is located_in the maxillary sinus." }, { "input": "mixed oligodendroglioma-astrocytoma", "output": "A diffuse glioma characterized by the presence of both an astrocytic and an oligodendroglial component and the absence of information on the idh genes status." }, { "input": "cervical spinal canal and spinal cord meningioma", "output": "A meningioma that arises from the meninges of the cervical region of the spinal cord." }, { "input": "mediastinal psammomatous neurilemmoma", "output": "A mediastinal neurilemmoma characterized by the presence of psammoma bodies." }, { "input": "epithelial malignant thymoma", "output": "Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. the majority of cases occur in the anterior mediastinum as masaoka stage ii or stage iii tumors. it is almost always invasive, it recurs frequently, and metastasizes in approximately 20% of the cases." }, { "input": "malignant type a thymoma", "output": "A type a thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize." }, { "input": "testis refractory cancer", "output": "Malignant testicular germ cell tumor that is resistant to treatment." }, { "input": "glandular-alveolar pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of gland-like spaces, irregular alveoli, and tubular structures." }, { "input": "refractory t lymphoblastic leukemia/lymphoma", "output": "T-lymphoblastic leukemia/lymphoma resistant to treatment" }, { "input": "barrett's adenocarcinoma", "output": "An adenocarcinoma arising from barrett metaplastic epithelium in the esophagus. there is evidence supporting the idea that the barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. adenocarcinomas arising in the setting of barrett esophagus are typically papillary and/or tubular. in terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002" }, { "input": "adult central nervous system mixed germ cell tumor", "output": "A central nervous system adult germ cell tumor that develops from misfolding and misplacement of embryonic cells into the lateral mesoderm, causing these cells to become entrapped in different areas of the brain, has_material_basis_in abnormally proliferating cells derives_from germ cells." }, { "input": "stroma-dominant and stroma-poor composite ganglioneuroblastoma", "output": "A neuroblastic tumor characterized by the presence of a ganglioneuroblastoma component and the formation of schwannian stroma which is the predominant component of the tumor volume." }, { "input": "schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma", "output": "A neuroblastic tumor characterized by the presence of a ganglioneuroblastoma component and the formation of schwannian stroma which constitutes more than fifty-percent of the tumor volume." }, { "input": "nipple duct carcinoma", "output": "A nipple carcinoma that is located_in the nipple duct." }, { "input": "sarcomatoid penile squamous cell carcinoma", "output": "A squamous cell carcinoma that arises from the penis and is characterized by the presence of malignant spindle-shaped cells." }, { "input": "duodenal gastrinoma", "output": "A gastrin-producing neuroendocrine tumor that arises from the duodenum. it is characterized by the presence of uniform cells that form pseudorosettes. the neoplastic cells have uniform nuclei and small amount of eosinophilic cytoplasm." }, { "input": "malignant spiradenoma", "output": "A very rare, aggressive carcinoma of the sweat glands arising from malignant transformation of a long standing spiradenoma. it usually grows in the upper extremities, lower extremities, trunk, and head and neck. it has the tendency to recur and metastasize most often to the lymph nodes, bones, and lungs." }, { "input": "cervical non-keratinizing squamous cell carcinoma", "output": "A cervical squamous cell carcinoma that is characterized by polygonal squamous cells growing in sheets or nests but keratin pearls are not present." }, { "input": "tamoxifen-related endometrial lesion", "output": "An endometrial disease that is caused by tamoxifen exposure." }, { "input": "lipid-cell variant infiltrating bladder urothelial carcinoma", "output": "A variant of infiltrating bladder urothelial carcinoma characterized by the presence of lipid laden tumor cells." }, { "input": "plasmacytoid variant infiltrating bladder urothelial carcinoma", "output": "A variant of infiltrating bladder urothelial carcinoma. it is characterized by plasmacytoid-like features." }, { "input": "nested variant infiltrating bladder urothelial carcinoma", "output": "A variant of infiltrating bladder urothelial carcinoma. it is characterized by a nested growth pattern." }, { "input": "microcystic variant infiltrating bladder urothelial carcinoma", "output": "A variant of infiltrating bladder urothelial carcinoma. it is characterized by microcysts formation. it is also associated with intracytoplasmic mucin deposits and calcification in cyst walls." }, { "input": "lymphoma-like variant infiltrating bladder urothelial carcinoma", "output": "A variant of infiltrating bladder urothelial carcinoma with lymphoma-like features." }, { "input": "breast malignant eccrine spiradenoma", "output": "A breast cancer that arises_from cutaneous sweat glands and is characterized by a focus of benign spiradenoma within or adjacent to the malignant tumor, as evidenced by increased mitotic rate, necrosis, nuclear atypia, pleomorphism, and hyperchromasia, loss of nested and trabecular growth patterns, and absence of a dual cell population." }, { "input": "sclerosing breast papilloma", "output": "A breast duct papilloma that is characterized by a central area of scarring and elastosis, derived from an obliterated duct." }, { "input": "cerebral falx meningioma", "output": "A meningioma that affects the falx cerebri." }, { "input": "varicose veins", "output": "A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin." }, { "input": "central nervous system osteosarcoma", "output": "An osteosarcoma arising from the brain or spinal cord." }, { "input": "familial glomangioma", "output": "A familial glomus tumor." }, { "input": "thyrotoxicosis", "output": "A thyroid gland disease that is characterized by excess thyroid hormone." }, { "input": "hyperthyroidism", "output": "A thyroid gland disease that involves an over production of thyroid hormone." }, { "input": "frontal convexity meningioma", "output": "A meningioma that affects the frontal sulcus." }, { "input": "supraglottis neoplasm", "output": "A benign or malignant neoplasm that affects the supraglottic area of the larynx." }, { "input": "alveoli adenoma", "output": "A benign, well circumscribed lung neoplasm morphologically characterized by the presence of cystic spaces resembling alveoli, lined by a simple cuboidal epithelium. the cystic spaces are surrounded by a spindle cell stroma which may show myxoid changes. it is a solitary, usually peripheral lung lesion. patients are usually asymptomatic and its discovery is an incidental finding during chest x-ray examination. surgical excision is curative." }, { "input": "pancoast tumor", "output": "A rare neoplastic syndrome characterized by obstruction of the thoracic outlet leading to compression of the brachial plexus and vessels within. it is usually caused by a malignant neoplasm in the superior pulmonary sulcus. the most commonly involved neoplasms are non-small cell lung carcinomas. clinical signs include horner's syndrome, shoulder pain radiating down the arm in the ulnar distribution followed by edema and atrophy of the affected extremity. clinical course usually leads to early local invasion of the bony thoracic structures. prognosis is highly stage-dependent." }, { "input": "penis mixed squamous cell carcinoma", "output": "A squamous cell carcinoma that arises from the penis and is characterized by a mixture of morphologic patterns (e.g., high grade squamous cell carcinoma and verrucous carcinoma or warty-basaloid carcinoma)." }, { "input": "hemarthrosis", "output": "Hemarthrosis" }, { "input": "benign pericardial teratoma", "output": "A mature teratoma that arises from the pericardium." }, { "input": "penis papillary carcinoma", "output": "A papillary carcinoma that is located_in the penis." }, { "input": "glomangiomyoma", "output": "A morphologic variant of the glomus tumor with architectural features similar to solid glomus tumor. it is characterized by the presence of elongated glomus cells which resemble mature smooth muscle." }, { "input": "liver fibrosarcoma", "output": "A fibrosarcoma of soft tissue and sarcoma of liver that is located_in the liver." }, { "input": "myxoid liposarcoma of the ovary", "output": "A myxoid liposarcoma that is located_in the ovary." }, { "input": "gastric signet ring cell adenocarcinoma", "output": "A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin." }, { "input": "sporadic breast cancer", "output": "A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their dna that would increase their risk for that cancer." }, { "input": "periocular meningioma", "output": "A meningioma that affects the periocular region." }, { "input": "pineal region meningioma", "output": "A meningioma that affects the pineal gland." }, { "input": "childhood ovarian embryonal carcinoma", "output": "An ovarian embryonal carcinoma that occurs in childhood." }, { "input": "testis polyembryoma", "output": "A rare malignant germ cell tumor that arises from the testis and is characterized by the presence of embryoid bodies." }, { "input": "chest wall parachordoma", "output": "A parachordoma arising from the chest wall." }, { "input": "bladder tubulo-cystic clear cell adenocarcinoma", "output": "A rare morphologic variant of bladder carcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a tubulo-cystic pattern." }, { "input": "bladder papillary clear cell adenocarcinoma", "output": "A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a papillary pattern." }, { "input": "olfactory groove meningioma", "output": "A meningioma that affects the olfactory sulcus." }, { "input": "pituitary stalk meningioma", "output": "A meningioma that affects the pituitary stalk." }, { "input": "frontal sinus inverted papilloma", "output": "A benign neoplasm that arises from the ciliated respiratory mucosa that lines the frontal sinus. it results from the invagination and proliferation of epithelial cells in the underlying stroma." }, { "input": "intraductal breast myoepitheliosis", "output": "A breast myoepitheliosis that is characterized by multifocal, often microscopic proliferation of myoepithelial cells in small ducts." }, { "input": "sarcomatous intrahepatic cholangiocarcinoma", "output": "A rare, aggressive variant of intrahepatic cholangiocarcinoma. it is characterized by the presence of adenocarcinoma cells that are intermingled with malignant pleomorphic spindle cells." }, { "input": "childhood central nervous system germinoma", "output": "A germinoma arising from the central nervous system during childhood." }, { "input": "myxomatous pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of myxomatous tissue that contains collections of malignant cells with prominent nucleoli." }, { "input": "classic congenital mesoblastic nephroma", "output": "A congenital mesoblastic nephroma characterized by the presence of interlacing fascicles of fibroblastic cells, low mitotic activity, and collagen formation." }, { "input": "cocaine abuse", "output": "A substance abuse that involves the recurring use of cocaine despite negative consequences." }, { "input": "maxillary sinus schneiderian papilloma", "output": "A papilloma that arises from the ciliated respiratory mucosa that lines the maxillary sinus. it is classified as inverted papilloma and oncocytic papilloma." }, { "input": "bladder mixed adenocarcinoma", "output": "A variant of bladder adenocarcinoma that histologically consists of more than one growth pattern such as enteric, mucinous or signet ring types." }, { "input": "bladder hepatoid adenocarcinoma", "output": "A rare variant of bladder adenocarcinoma. it is characterized by the presence of a mixture of polygonal hepatoid cells and glandular adenocarcinoma cells." }, { "input": "fetal adenoma", "output": "A thyroid gland adenoma composed of microfollicular structures." }, { "input": "vaginal tubulovillous adenoma", "output": "A vaginal adenoma that is a polyp that resembles colorectal tubulovillous adenoma." }, { "input": "extrahepatic bile duct cystadenoma", "output": "A bile duct cystadenoma located_in an extrahepatic bile duct." }, { "input": "cellular phase chronic idiopathic myelofibrosis", "output": "Primary myelofibrosis characterized by bone marrow hypercellularity and the presence of atypical megakaryocytes. there is no increase in the percentage of myeloblasts and no significant increase in reticulin or collagen fibrosis in the bone marrow." }, { "input": "fibroepithelial polyp of urethra", "output": "A benign polypoid lesion of mesodermal origin that arises from the urethra." }, { "input": "nephrogenic adenoma of the urethra", "output": "A metaplastic lesion of the urothelium found in the urethra. it is characterized by the presence of aggregates of cuboidal or hobnail cells and represents a reaction of the urothelium to injury caused by instrumentation, surgery or calculi." }, { "input": "lipodystrophy", "output": "A connective tissue disease that is characterized by marked reduction, absence, and/or the redistribution of adipose tissue." }, { "input": "periampullary adenocarcinoma", "output": "A cancer that forms near the ampulla of vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine)." }, { "input": "neuronitis", "output": "A central nervous system disease that is characterized by neuron inflammation." }, { "input": "mature gastric teratoma", "output": "A mature teratoma that has_material_basis_in gastric tissue." }, { "input": "anal canal paget's disease", "output": "Paget disease involving the squamous epithelium of the anal canal." }, { "input": "osteochondrosis", "output": "An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone." }, { "input": "septic arthritis", "output": "An arthritis that involves infection by a pathogen located_in joint." }, { "input": "breast columnar cell mucinous carcinoma", "output": "A breast mucinous carcinoma that is characterized by tall columnar cells with basal, bland nuclei, intracytoplasmic and extracytoplasmic mucin and is grossly solid." }, { "input": "epiglottis cancer", "output": "Malignant neoplasm of anterior surface of epiglottis" }, { "input": "gallbladder lymphoma", "output": "A lymphoma that arises from the gallbladder, with the bulk of the tumor located at this site." }, { "input": "thymus clear cell carcinoma", "output": "A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm." }, { "input": "thymus sarcomatoid carcinoma", "output": "A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of tumor cells morphologically resembling soft tissue sarcoma." }, { "input": "adrenal gland ganglioneuroblastoma", "output": "A ganglioneuroblastoma arising from the adrenal gland." }, { "input": "pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma", "output": "A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll) that lacks somatic hypermutations of the immunoglobulin heavy chain (igh) genes, implying pregerminal center b-cell origin. microarray gene expression profiling studies have demonstrated the expression of zap-70 gene (syk family tyrosine kinase) in this subset of cll/cll. patients with this variant of cll/sll have an unfavorable prognosis compared to those with somatic hypermutations of the igh genes, with a median survival of approximately 6-8 years." }, { "input": "malignant childhood germ cell neoplasm", "output": "A malignant germ cell tumor that occurs during childhood." }, { "input": "pancreatic invasive intraductal papillary-mucinous carcinoma", "output": "A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of a focal or multifocal invasive carcinomatous component. the invasive carcinoma is either colloid or ductal adenocarcinoma." }, { "input": "appendiceal l-cell glucagon-like peptide producing tumor", "output": "A neuroendocrine tumor arising from the wall of the appendix, producing glucagon-like peptides. morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns." }, { "input": "fibroosseous pseudotumor of digits", "output": "A non-neoplastic soft tissue disorder characterized by the localized formation of reactive fibrous and bone tissues. it usually occurs in the subcutaneous tissue of the proximal phalanx. less frequently, it involves the toe. it presents with swelling and pain of the affected area. the prognosis is excellent. however, incomplete excision may lead to the re-growth of the lesion." }, { "input": "complement component 5 deficiency", "output": "A complement deficiency that is characterized by susceptibility to recurrent bacterial infections especially to infections of enveloped organisms, and has_material_basis_in mutation in the complement component 5 (c5) gene on chromosome 9q33.2 that encodes the fifth component of complenent, a part of the innate immune system." }, { "input": "thyroid gland hurthle cell carcinoma", "output": "A thyroid gland follicular carcinoma that is characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli." }, { "input": "thyroid hurthle cell adenoma", "output": "A thyroid gland adenoma composed of large cells with abundant granular eosinophilic cytoplasm and large nuclei with prominent nucleoli." }, { "input": "gallbladder melanoma", "output": "A melanoma that arises from the gallbladder." }, { "input": "interstitial myocarditis", "output": "Inflammation of the heart characterized by infiltration of the interstitial tissues by inflammatory cells, histiocytes, and the formation of granulomas. giant cells are often present." }, { "input": "endocervical type cervical adenomyoma", "output": "A cervical adenomyoma that is located_in the endocervix and is characterized by a well circumscribed neoplasm composed of irregularly shaped, benign endocervical-type glands, admixed with myomatous smooth muscle." }, { "input": "endometrial type cervical adenomyoma", "output": "A cervical adenomyoma that is characterized by glands and cysts lined by a single layer of endocervical-type mucinous epithelium admixed with smooth muscle." }, { "input": "cervical atypical polypoid adenomyoma", "output": "A cervical adenomyoma that is tumor of endometrium, lower uterine segment and endocervix and is characterized by atypical complex glands with squamous metaplasia mixed with myofibromatous stroma." }, { "input": "fallopian tube gestational choriocarcinoma", "output": "A gestational choriocarcinoma that is located_in the fallopian tube." }, { "input": "gestational uterine corpus choriocarcinoma", "output": "A gestational choriocarcinoma that is located_in the uterine corpus." }, { "input": "uterine corpus choriocarcinoma", "output": "A choriocarcinoma that is located_in the uterine corpus." }, { "input": "mediastinitis", "output": "A connective tissue disease characterized by inflammation located_in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities." }, { "input": "papillary pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of numerous papillary structures that are lined by cells with prominent nucleoli." }, { "input": "hepatoid pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of hepatoid cells collections." }, { "input": "myotonic cataract", "output": "A cataract that is characterized by multicolored, iridescent opacification of the lens of the eye, and associated with myotonic dystrophy." }, { "input": "myocarditis", "output": "An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle." }, { "input": "tertiary syphilis", "output": "A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems." }, { "input": "sacral spinal canal and spinal cord meningioma", "output": "A meningioma that arises from the meninges of the sacral region of the spinal cord." }, { "input": "hilar lung carcinoma", "output": "A lung carcinoma arising from the hilum of the lung." }, { "input": "lung superior sulcus carcinoma", "output": "A carcinoma originating from the apical lung. most superior sulcus lung carcinomas are bronchogenic carcinomas. this carcinoma may be associated with pancoast syndrome. lt is also known as pancoast tumor." }, { "input": "fallopian tube cystadenofibroma", "output": "A fallopian tube adenofibroma that is characterized by the presence of cysts and/or cystic spaces." }, { "input": "upper clivus meningioma", "output": "A meningioma that affects the upper clivus." }, { "input": "penile urethral cancer", "output": "A primary or metastatic malignant neoplasm that affects the penile urethra." }, { "input": "central breast papilloma", "output": "A breast duct papilloma that is located_in a major duct." }, { "input": "microscopic breast papilloma", "output": "A benign papillary neoplasm that arises in a terminal ductal lobular unit. it is characterized by the presence of a fibrovascular core that is lined by benign epithelial and myoepithelial proliferations. peripheral breast papillomas are often multiple and are usually found microscopically. patients are often asymptomatic." }, { "input": "atypical breast papilloma", "output": "A breast duct papilloma that is characterized by the presence of cells that are abnormal but are not yet malignant." }, { "input": "periapical periodontitis", "output": "Chronic apical periodontitis" }, { "input": "intrahepatic biliary papillomatosis", "output": "A biliary papillomatosis located_in an intrahepatic bile duct." }, { "input": "inflammatory liposarcoma", "output": "A rare morphologic variant of well differentiated liposarcoma occurring most often in the retroperitoneum. it is characterized by the presence of a predominant inflammatory infiltrate composed of lymphoplasmacytic aggregates." }, { "input": "lower clivus meningioma", "output": "A meningioma that affects the lower clivus." }, { "input": "periodontitis", "output": "Chronic periodontitis" }, { "input": "meningeal melanomatosis", "output": "A central nervous system melanocytic neoplasm that is characterized as an extra-axial well-encapsulated malignant tumour with diffuse meningeal growth and dark coloration (due to high melanin contents)." }, { "input": "adult pleomorphic rhabdomyosarcoma", "output": "An aggressive rhabdomyosarcoma occurring in adults. the neoplasm is characterized by the presence of bizarre round, spindle, and polygonal cells. clinical presentation includes a rapidly enlarging painful mass usually in the lower extremities." }, { "input": "chronic rhinitis", "output": "A rhinitis which is persistent and long-lasting. it may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding." }, { "input": "vulva fibroepithelial polyp", "output": "A polypoid lesion that arises from the vulva and is characterized by the presence of fibrovascular stroma lined by squamous epithelium. there is no evidence of epithelial atypia." }, { "input": "bulbomembranous urethral cancer", "output": "A malignant neoplasm that affects the bulbomembranous part of the urethra." }, { "input": "ureter tuberculosis", "output": "An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures." }, { "input": "anterior urethra cancer", "output": "A female urethral cancer located_in the anterior urethra." }, { "input": "synovial angioma", "output": "A rare hemangioma arising from synovium lining surfaces." }, { "input": "intratubular embryonal carcinoma", "output": "An embryonal testis carcinoma that is located within a tubule." }, { "input": "adult epithelioid sarcoma", "output": "An epithelioid sarcoma occurring in adults." }, { "input": "peritonitis", "output": "A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. the symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output." }, { "input": "clear cell squamous cell skin carcinoma", "output": "A squamous cell carcinoma of the skin with a prominent clear cell component." }, { "input": "atypical follicular adenoma", "output": "An encapsulated or well-circumscribed tumor composed of well-differentiated follicular cells with well-developed or partially developed nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. that is this is a tumor indeterminate between follicular adenoma and follicular carcinoma. tumors in which vascular invasion has been excluded by all means are called non-invasive follicular thyroid neoplasms with papillary-like nuclear features. (who 2017)" }, { "input": "scabies", "output": "A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades." }, { "input": "cataract", "output": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision." }, { "input": "mixed endometrial stromal and smooth muscle tumor", "output": "A uterine corpus cancer that has_material_basis_in endometrial stroma and smooth muscle cells." }, { "input": "lymph node palisaded myofibroblastoma", "output": "A lymph node benign neoplasm that is composed of myoid or myofibroblastic spindle cells, with focal palisading and so-called amianthoid fibers." }, { "input": "nonossifying fibromyxoid tumor", "output": "A rare soft tissue tumor of uncertain lineage characterized by the presence of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. metaplastic bone formation is not present." }, { "input": "early invasive cervical adenocarcinoma", "output": "A cervical adenocarcinoma that is characterized by tumor cells that are identical to those in adenocarcinoma in situ (acis) and mcroscopic findings that suggest invasion." }, { "input": "sclerosing adenosis of breast", "output": "A proliferative type fibrocystic change of breast that is characterized by enlarged lobules that are distorted by scar-like tissue and excess glandular tissue." }, { "input": "auditory system cancer", "output": "An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs." }, { "input": "perineural angioma", "output": "A hemangioma arising from perineural tissues." }, { "input": "microglandular adenosis of breast", "output": "A rare variant of breast adenosis characterized by the proliferation of small round glands in a collagenous stroma. the epithelial cells are cuboidal and there are no myopepithelial cells present. there is no evidence of atypia." }, { "input": "childhood choriocarcinoma of the ovary", "output": "A choriocarcinoma of the ovary that is present during childhood." }, { "input": "appendicitis", "output": "A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. the infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever." }, { "input": "villoglandular variant cervical mucinous adenocarcinoma", "output": "A cervical mucinous adenocarcinoma that is characterized by a dominant pattern of well differentiated, thin and simple papillary structures without broad, fibrovascular cores." }, { "input": "intestinal variant cervical mucinous adenocarcinoma", "output": "A cervical mucinous adenocarcinoma that is characterized by areas of intestinal type differentiation." }, { "input": "endocervical type cervical mucinous adenocarcinoma", "output": "A cervical mucinous adenocarcinoma characterized by the presence of malignant glandular cells that resemble those of the endocervix." }, { "input": "aortic malignant tumor", "output": "A vascular cancer that is located_in the aorta." }, { "input": "epithelioid malignant peripheral nerve sheath tumor", "output": "A rare variant of malignant peripheral nerve sheath tumor composed predominantly or exclusively of epithelioid cells." }, { "input": "complement component 3 deficiency", "output": "A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has_material_basis_in autosomal recessive inheritance of mutation in the c3 gene on chromosome 19p13.3, has_symptom recurrent bacterial infections." }, { "input": "pseudoglandular variant testicular seminoma", "output": "A morphologic variant of testicular seminoma characterized by the presence of seminoma cells arranged in pseudoglandular patterns and few lymphocytes." }, { "input": "glassy cell variant cervical adenosquamous carcinoma", "output": "A cervical adenosquamous carcinoma that is a rare form and is composed of cells with a glass-like cytoplasm." }, { "input": "enteric pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of immature glands." }, { "input": "chordoid meningioma", "output": "A meningioma that is characterized by the predominance of tissues that are histologically similar to chordoma." }, { "input": "adult malignant schwannoma", "output": "A malignant peripheral nerve sheath tumor occurring during adulthood." }, { "input": "reticular pattern testicular yolk sac tumor", "output": "A yolk sac tumor that arises from the testis and is characterized by the presence of a meshwork of small vacuolated cells resulting in a honeycomb appearance." }, { "input": "adult type testicular granulosa cell tumor", "output": "A rare sex cord-stromal tumor that arises from the testis in adults. gynecomastia is present in approximately a quarter of the patients. several morphologic patterns have been identified and include insular, gyriform, trabecular, pseudosarcomatous, and solid. metastases occur in approximately twenty percent of the cases." }, { "input": "osteoarthritis", "output": "An arthritis that has_material_basis_in worn out cartilage located_in joint." }, { "input": "trombiculiasis", "output": "A mite infestation that involves rash caused by leptotrombidium deliense." }, { "input": "osteochondritis dissecans", "output": "An ischemic bone disease that results_in necrosis located_in epiphysis." }, { "input": "cork-handlers' disease", "output": "An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus penicillium glabrum. the symptoms include dyspnea, wheezing cough, fever and asthenia." }, { "input": "malignant cornea melanoma", "output": "A melanoma within the cornea of the eye." }, { "input": "meckel's diverticulitis", "output": "A diverticulits characterized by the inflammation of a congenital diverticulum, which is a slight bulge of the small intestine present at birth." }, { "input": "microinvasive cervical squamous cell carcinoma", "output": "A cervical squamous cell carcinoma that is characterized by invasion which diagnosed by microscopy only. invasion is limited to measured stromal invasion with a maximum depth of 5_mm and no wider than 7_mm diameter." }, { "input": "extrinsic allergic alveolitis", "output": "An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss." }, { "input": "childhood kidney angiomyolipoma", "output": "An angiomyolipoma occurring in childhood." }, { "input": "kidney angiomyolipoma", "output": "An angiomyolipoma arising from the kidney." }, { "input": "carcinoma arising in nasal papillomatosis", "output": "A rare squamous cell carcinoma that either arises from or is associated with the presence of inverted papilloma in the nose." }, { "input": "congenital fibrosarcoma", "output": "A fibrosarcoma that occurs in infants. it shares identical morphologic features with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that results in etv6-ntrk3 gene fusion. it usually affects the superficial and deep soft tissues of the extremities. the prognosis is generally much more favorable than for adult fibrosarcoma, and it rarely metastasizes." }, { "input": "colloid adenoma", "output": "A thyroid gland adenoma composed of large size follicles." }, { "input": "malignant glandular tumor of peripheral nerve sheath", "output": "A variant of malignant peripheral nerve sheath tumor characterized by the presence of glandular epithelium." }, { "input": "follicular infundibulum tumor", "output": "A tumor involving the follicular infundibulum." }, { "input": "retinal melanoma", "output": "A melanoma affecting the retinal portion of the eye. --2003" }, { "input": "breast apocrine carcinoma in situ", "output": "A breast carcinoma in situ that is characterized by abundant eosinophilic apocrine cytoplasm and large nuclei. it is a variant of ductal carcinoma in situ of the breast." }, { "input": "physiological polycythemia", "output": "Polycythemia that is not pathologic." }, { "input": "polycythemia", "output": "A bone marrow disease characterized by an increased number of red blood cells in the bloodstream resulting in thicker blood and reduced blood flow." }, { "input": "thyroid malformation", "output": "An anatomic abnormality of the thyroid gland." }, { "input": "intestinal obstruction", "output": "Unspecified intestinal obstruction, unspecified as to partial versus complete obstruction" }, { "input": "afferent loop syndrome", "output": "A postgastrectomy syndrome that is characterized by obstruction of the afferent loop that arises after gastric surgery with gastrojejunostomy reconstruction." }, { "input": "postgastrectomy syndrome", "output": "Postgastric surgery syndromes" }, { "input": "ileus", "output": "A condition caused by the lack of intestinal peristalsis or intestinal motility without any mechanical obstruction. this interference of the flow of intestinal contents often leads to intestinal obstruction. ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced." }, { "input": "paralytic ileus", "output": "Paralytic ileus" }, { "input": "brachial plexus lesion", "output": "A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus." }, { "input": "intestinal volvulus", "output": "An intestinal obstruction characterized by abnormal rotation of the intestines." }, { "input": "intussusception", "output": "Intussusception" }, { "input": "intestinal impaction", "output": "Other impaction of intestine" }, { "input": "cyclothymic disorder", "output": "A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes." }, { "input": "riboflavin deficiency", "output": "A nutritional deficiency disease that is characterized by stomatitis, cheilosis, glossitis, conjunctivitis, and anemia, develops_from vitamin b2 (riboflavin) deficiency, has_symptom red chapped lips, painful swollen tongue, sore throat, blurred vision, and fatigue, and has_material_basis_in inadequate intake, endocrine disorder, liver disorder, alcoholism, and dialysis." }, { "input": "pyridoxine deficiency anemia", "output": "A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin b6), and has_material_basis_in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid)." }, { "input": "choline deficiency disease", "output": "A nutritional deficiency disease that is characterized by deficiency of choline, which has been associated with development of fatty liver, and possibly has_material_basis_in inadequate intake and exacerbated by a genetic predisposition." }, { "input": "pellagra", "output": "A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin b3), has_symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has_material_basis_in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects." }, { "input": "aicardi syndrome", "output": "A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye." }, { "input": "corneal ulcer", "output": "Corneal ulcer" }, { "input": "retinoschisis", "output": "Unspecified retinoschisis" }, { "input": "retinal degeneration", "output": "A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina." }, { "input": "influenza", "output": "A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in influenzavirus a, has_material_basis_in influenzavirus b, or has_material_basis_in influenzavirus c, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness." }, { "input": "localized scleroderma", "output": "Localized scleroderma [morphea]" }, { "input": "whipple disease", "output": "Whipple's disease" }, { "input": "actinomycosis", "output": "A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in actinomyces israelii, has_material_basis_in actinomyces gerencseriae, has_material_basis_in actinomyces naeslundii, has_material_basis_in actinomyces odontolyticus, has_material_basis_in actinomyces viscosus, has_material_basis_in actinomyces meyeri, has_material_basis_in propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures." }, { "input": "arthritis", "output": "A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint." }, { "input": "rheumatic myocarditis", "output": "Acute rheumatic heart disease, unspecified" }, { "input": "transient retinal arterial occlusion", "output": "Transient retinal artery occlusion" }, { "input": "retinal artery occlusion", "output": "Sudden ischemia in the retina due to blocked blood flow through the central retinal artery or its branches leading to sudden complete or partial loss of vision, respectively, in the eye." }, { "input": "maple bark strippers' lung", "output": "An opportunistic mycosis that is located_in lungs caused by inhalation of fungal spores while stripping the bark from maple logs, has_material_basis_in cryptostroma corticale." }, { "input": "mucormycosis", "output": "An opportunistic mycosis that results_in fungal infection located_in sinuses, located_in brain, or located_in lungs of immunocompromised people, has_material_basis_in mucorales molds." }, { "input": "polyhydramnios", "output": "A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac." }, { "input": "rheumatoid arthritis interstitial lung disease", "output": "An interstitial lung disease that is characterized by the development of pleuroparenchymal disease secondary to rheumatoid arthritis, including pleural effusions, pleural fibrosis, pulmonary vascular disease, and airway complications." }, { "input": "hereditary night blindness", "output": "Congenital night blindness" }, { "input": "night blindness", "output": "A retinal disease that is characterized by difficulty or the inability to see in relatively low light." }, { "input": "lung disease", "output": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide." }, { "input": "hereditary retinal dystrophy", "output": "Hereditary retinal dystrophy" }, { "input": "fundus dystrophy", "output": "A group of disorders involving predominantly the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the retina; retinal pigment epithelium; bruch membrane; choroid; or a combination of these tissues." }, { "input": "bullous skin disease", "output": "A dermatitis that is characterized by blisters filled with a watery fluid, located_in skin. the disease is associated with the amount of gluten ingested." }, { "input": "impetigo herpetiformis", "output": "An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy." }, { "input": "impetigo", "output": "A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous." }, { "input": "dermatitis herpetiformis", "output": "Dermatitis herpetiformis" }, { "input": "bullous pemphigoid", "output": "A pemphigoid that is characterized by large blisters." }, { "input": "juvenile dermatitis herpetiformis", "output": "Chronic bullous disease of childhood" }, { "input": "subcorneal pustular dermatosis", "output": "Subcorneal pustular dermatitis" }, { "input": "bartholin's duct cyst", "output": "A female reproductive system disease that is characterized by a fluid-filled swelling in the bartholin's glands." }, { "input": "puerperal pulmonary embolism", "output": "Thromboembolism in pregnancy" }, { "input": "acute pulmonary heart disease", "output": "Other pulmonary embolism with acute cor pulmonale" }, { "input": "cor pulmonale", "output": "A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs." }, { "input": "acute cor pulmonale", "output": "Other pulmonary embolism with acute cor pulmonale" }, { "input": "barbiturate abuse", "output": "A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences." }, { "input": "monocytic leukemia", "output": "A myeloid leukemia that is characterized by a dominance of monocytes in the marrow." }, { "input": "ulcer of lower limbs", "output": "A chronic ulcer of skin where the ulcer is not a decubitus ulcer." }, { "input": "polymyalgia rheumatica", "output": "A collagen disease that is characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck." }, { "input": "hypopharynx cancer", "output": "A pharynx cancer that is located_in the hypopharynx." }, { "input": "gastroesophageal reflux disease", "output": "Gastro-esophageal reflux disease without esophagitis" }, { "input": "herpes zoster", "output": "A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. the infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia." }, { "input": "reticulosarcoma", "output": "An antiquated term that refers to a non-hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes." }, { "input": "collagen disease", "output": "A connective tissue disease that characterized by connective tissue disease that has_material_basis_in inheritable defects in collagen." }, { "input": "sezary's disease", "output": "S\u00e9zary disease" }, { "input": "hodgkin's lymphoma, lymphocytic-histiocytic predominance", "output": "Lymphocyte-rich hodgkin lymphoma" }, { "input": "chronic fatigue syndrome", "output": "A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions." }, { "input": "malignant hyperthermia", "output": "A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature and that has_material_basis_in heterozygous mutation in the ryanodine receptor gene (ryr1) on chromosome 19q13. manifestations of malignant hyperthermia (mh) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine)." }, { "input": "chronic ulcer of skin", "output": "Non-pressure chronic ulcer of skin, not elsewhere classified" }, { "input": "chronic myeloid leukemia", "output": "A myeloid leukemia that is characterized by over production of white blood cells." }, { "input": "pyoderma gangrenosum", "output": "Pyoderma gangrenosum" }, { "input": "vallecula cancer", "output": "Malignant neoplasm of vallecula" }, { "input": "oropharynx cancer", "output": "A pharynx cancer that is located_in the oropharynx." }, { "input": "biotinidase deficiency", "output": "A multiple carboxylase deficiency that involves a deficiency in biotinidase as the body is not able to use biotin and results in biotin deficiency, and has_material_basis_in homozygous or compound heterozygous mutation in the btd gene on chromosome 3p25." }, { "input": "lip cancer", "output": "Malignant neoplasm of lip" }, { "input": "herpes simplex", "output": "A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in human herpesvirus 1 or has_material_basis_in human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person." }, { "input": "hodgkin's lymphoma", "output": "A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell." }, { "input": "infectious mononucleosis", "output": "A viral infectious disease that results in inflammation, located in pharynx, has_material_basis_in human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly." }, { "input": "multiple carboxylase deficiency", "output": "An amino acid metabolic disorder that involves failures of carboxylation enzymes." }, { "input": "lichen nitidus", "output": "Lichen nitidus" }, { "input": "lichen disease", "output": "Lichen simplex chronicus" }, { "input": "ulcerative colitis", "output": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores." }, { "input": "soft palate cancer", "output": "Malignant neoplasm of soft palate" }, { "input": "burkitt lymphoma", "output": "A mature b-cell neoplasm of b-cells found in the germinal center." }, { "input": "holocarboxylase synthetase deficiency", "output": "A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase." }, { "input": "acute vascular insufficiency of intestine", "output": "Ischemia of the intestine that is rapid in onset." }, { "input": "chronic monocytic leukemia", "output": "Chronic myelomonocytic leukemia" }, { "input": "scarlet fever", "output": "An upper respiratory tract disease described as an acute contagious disease caused by group a bacteria of the genus streptococcus (especially various strains of s. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash." }, { "input": "upper gum cancer", "output": "Malignant neoplasm of upper gum" }, { "input": "gum cancer", "output": "Malignant neoplasm of gum" }, { "input": "herpetic whitlow", "output": "A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in human herpesvirus 1 and has_material_basis_in human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes." }, { "input": "peyronie's disease", "output": "Induration penis plastica" }, { "input": "oral cavity cancer", "output": "A gastrointestinal system cancer that is located_in the oral cavity." }, { "input": "recurrent hypersomnia", "output": "A sleep disorder that involves recurring bouts of excessive amounts of sleepiness." }, { "input": "diplegia of upper limb", "output": "Diplegia of upper limbs" }, { "input": "measles", "output": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. the infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash." }, { "input": "hodgkin's lymphoma, lymphocytic depletion", "output": "Lymphocyte depleted hodgkin lymphoma" }, { "input": "nervous system disease", "output": "A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system." }, { "input": "upper lip cancer", "output": "Malignant neoplasm of external upper lip" }, { "input": "kaposi's sarcoma", "output": "A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in human herpesvirus 8 (hhv8)." }, { "input": "prostate carcinoma in situ", "output": "An in situ carcinoma that is located_in the prostate." }, { "input": "uvula cancer", "output": "Malignant neoplasm of uvula" }, { "input": "phlebitis", "output": "A vein disease that is characterized by inflammation of a vein." }, { "input": "duodenitis", "output": "Duodenitis" }, { "input": "tongue cancer", "output": "Malignant neoplasm of base of tongue" }, { "input": "vasculitis", "output": "A vascular disease that is characterized by inflammation of the blood vessels." }, { "input": "hodgkin's lymphoma, mixed cellularity", "output": "Mixed cellularity hodgkin lymphoma" }, { "input": "chickenpox", "output": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. the infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters." }, { "input": "vein disease", "output": "A vascular disease that is located_in a vein." }, { "input": "postcricoid region cancer", "output": "Malignant neoplasm of postcricoid region" }, { "input": "lip carcinoma in situ", "output": "An oral cavity carcinoma in situ that is located_in the lip." }, { "input": "aryepiglottic fold cancer", "output": "Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect" }, { "input": "maxillary sinus cholesteatoma", "output": "A cholesteatoma located_in paranasal sinus." }, { "input": "eating disorder", "output": "A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health." }, { "input": "perinatal necrotizing enterocolitis", "output": "Necrotizing enterocolitis" }, { "input": "alcoholic gastritis", "output": "Alcoholic gastritis" }, { "input": "paraneoplastic polyneuropathy", "output": "A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. pathologically, there are inflammatory changes in peripheral nerves. the most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (adams et al., principles of neurology, 6th ed, p1334)" }, { "input": "myeloid sarcoma", "output": "Myeloid sarcoma" }, { "input": "skin carcinoma in situ", "output": "A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues." }, { "input": "tonsillar pillar cancer", "output": "Malignant neoplasm of tonsillar pillar (anterior) (posterior)" }, { "input": "anorexia nervosa", "output": "An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image." }, { "input": "cholesteatoma", "output": "A keratosis that is characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction." }, { "input": "mycosis fungoides", "output": "Mycosis fungoides" }, { "input": "myeloid leukemia", "output": "A leukemia that is located_in myeloid tissue." }, { "input": "neuropathy", "output": "A nervous system disease that is located_in nerves or nerve cells." }, { "input": "cheek mucosa cancer", "output": "Malignant neoplasm of cheek mucosa" }, { "input": "genital herpes", "output": "A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in human herpesvirus 1 or has_material_basis_in human herpesvirus 2, which is transmitted_by sexual contact. the infection has_symptom sores, has_symptom fever, and has_symptom swollen glands." }, { "input": "neurofibromatosis", "output": "Neurofibromatosis (nonmalignant)" }, { "input": "decubitus ulcer", "output": "A chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure." }, { "input": "in situ carcinoma", "output": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues." }, { "input": "vascular dementia", "output": "A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain." }, { "input": "milker's nodule", "output": "A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. the infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy." }, { "input": "anaerobic pneumonia", "output": "An aspiration pneumonia caused by anaerobic bacteria like bacteroides fragilis, peptostreptococcus, anaerobic streptococci, fusobacterium species (fusobacterium nucleatum and fusobacterium necrophoram). lung abscess and empyema are diagnosed in this disease." }, { "input": "carotid body cancer", "output": "A vascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery." }, { "input": "smallpox", "output": "A viral infectious disease that results in infection located in skin, has_material_basis_in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk." }, { "input": "leukoplakia of penis", "output": "Leukoplakia of penis" }, { "input": "bacterial pneumonia", "output": "A pneumonia involving inflammation of the lungs caused by bacteria." }, { "input": "seborrheic dermatitis", "output": "A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast malassezia furfur. the symptoms include itching, skin lesions and scales, redness, plaques and hair loss." }, { "input": "erythema infectiosum", "output": "Erythema infectiosum [fifth disease]" }, { "input": "gastric mucosal hypertrophy", "output": "Other gastritis" }, { "input": "pyomyositis", "output": "Infective myositis" }, { "input": "acute megakaryocytic leukemia", "output": "An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers." }, { "input": "contagious pustular dermatitis", "output": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. the infection has_symptom lesions on the finger, hand, arm, face, and penis." }, { "input": "crohn's disease", "output": "An intestinal disease that involves inflammation located_in intestine." }, { "input": "rubella", "output": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. the infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis." }, { "input": "disseminated chorioretinitis", "output": "Disseminated chorioretinal inflammation" }, { "input": "breast carcinoma in situ", "output": "An in situ carcinoma that is located_in the breast." }, { "input": "eye carcinoma in situ", "output": "A carcinoma in situ that is characterized by the spread of cancer in the eye and the lack of invasion of surrounding tissues." }, { "input": "lung carcinoma in situ", "output": "An in situ carcinoma that is located_in the lung." }, { "input": "trachea carcinoma in situ", "output": "An in situ carcinoma that is located_in the trachea." }, { "input": "intermediate coronary syndrome", "output": "Unstable angina" }, { "input": "heterophyiasis", "output": "A parasitic helminthiasis infectious disease that involves intestinal infection by the parasite of the genus heterophyes. the symptoms are diarrhea and colicky abdominal pain. migration of the eggs to the heart, results in fatal myocardial and valvular damage. brain can also be infected." }, { "input": "colon carcinoma in situ", "output": "An intestine carcinoma in situ that is located_in the colon." }, { "input": "parasitic helminthiasis infectious disease", "output": "A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes." }, { "input": "hodgkin's lymphoma, nodular sclerosis", "output": "Nodular sclerosis hodgkin lymphoma" }, { "input": "metagonimiasis", "output": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by metagonimus yokogawai. the symptoms are diarrhea and colicky abdominal pain. the heart and brain can also be infected." }, { "input": "sublingual gland cancer", "output": "A salivary gland cancer that is located_in the sublingual gland." }, { "input": "fascioliasis", "output": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by fasciola hepatica or fasciola gigantica. during the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa." }, { "input": "salivary gland cancer", "output": "An oral cavity cancer that is located_in the salivary gland." }, { "input": "lupus erythematosus", "output": "An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs." }, { "input": "tonsil cancer", "output": "Malignant neoplasm of tonsil" }, { "input": "pulmonary subvalvular stenosis", "output": "Pulmonary infundibular stenosis" }, { "input": "acute monocytic leukemia", "output": "A monocytic leukemia where the majority of monocytic cells are promonocytes." }, { "input": "actinic keratosis", "output": "Actinic keratosis" }, { "input": "molluscum contagiosum", "output": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. the infection has_symptom lesions which are flesh-colored with a pit in the center." }, { "input": "neuromyelitis optica", "output": "A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis)." }, { "input": "penis carcinoma in situ", "output": "An in situ carcinoma that is located_in the penis." }, { "input": "fasciolopsiasis", "output": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by fasciolopsis buski. the symptoms include diarrhea, abdominal pain, fever, ascites, anasarca and intestinal obstruction." }, { "input": "rosacea", "output": "Rosacea" }, { "input": "lower lip cancer", "output": "Malignant neoplasm of external lower lip" }, { "input": "chorioretinitis", "output": "Unspecified chorioretinal inflammation" }, { "input": "pityriasis rosea", "output": "A dermatitis that is characterized by an initial large round spot on the chest, abdomen, or back, often referred to as a herald patch, that is usually followed within a week by a distinctive pattern of similar but smaller papules on the torso, arms, and legs." }, { "input": "psoriasis", "output": "A skin disease that is characterized by patches of thick red skin and silvery scales." }, { "input": "mitochondrial encephalomyopathy", "output": "A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. these are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (from adams et al., principles of neurology, 6th ed, pp984-5)" }, { "input": "progressive myoclonus epilepsy", "output": "A variable age at onset electroclinical syndrome characterized by a relentlessly progressive disease course until death." }, { "input": "tinea nigra", "output": "A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions." }, { "input": "dermatophytosis", "output": "A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source." }, { "input": "leukoplakia of vagina", "output": "A vaginal disease that is a precancerous lesion that is characterized by the presence of white plaques which cannot be rubbed off. histology shows increased keratin." }, { "input": "skin melanoma", "output": "A skin cancer that has_material_basis_in melanocytes." }, { "input": "autoimmune thrombocytopenic purpura", "output": "A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies." }, { "input": "primary thrombocytopenia", "output": "Other primary thrombocytopenia" }, { "input": "learning disability", "output": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information." }, { "input": "atrophic gastritis", "output": "Chronic atrophic gastritis" }, { "input": "wilson disease", "output": "A metal metabolism disease that is characterized by excess copper stored in various body tissues, particularly the liver, brain, and corneas of the eyes." }, { "input": "retromolar area cancer", "output": "Malignant neoplasm of retromolar area" }, { "input": "evans' syndrome", "output": "Evans syndrome" }, { "input": "plantar fascial fibromatosis", "output": "A connective tissue disease characterized by progressive fibrosis and thickening located_in the palmar fascia and has_symptom early painless nodules, has_symptom decreased range of motion, has_symptom weakened grip, and has_symptom eventual contracture." }, { "input": "waldeyer's ring cancer", "output": "Malignant neoplasm of waldeyer's ring" }, { "input": "seborrheic infantile dermatitis", "output": "A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by malassezia furfur. it is occasionally linked to immune disorders. the symptoms include thick, crusty, yellow or brown scales over the child's scalp." }, { "input": "lattice corneal dystrophy", "output": "An epithelial-stromal tgfbi dystrophy that is characterized by recurrent erosions and lattice line refractile and fleck-like opacification located_in the cornea, amyloid deposits beginning in the anterior stroma, and progressive vision loss later in life, and has_material_basis_in autosomal dominant inheritance of mutation of transforming growth factor beta-induced gene located in chromosome 5q31.1, which encodes keratoepithelin. abnormalities lead to increased amyloid protein deposition and disruption of the corneal surface." }, { "input": "diabetic retinopathy", "output": "Disease of the retina as a complication of diabetes mellitus. it is characterized by the progressive microvascular complications, such as aneurysm, interretinal edema, and intraocular pathologic neovascularization." }, { "input": "sideroblastic anemia", "output": "An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes)." }, { "input": "cowpox", "output": "A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in cowpox virus, which is transmitted_by contact with an infected animal. the infection results_in_formation_of vesicopustular lesions on the hands or face." }, { "input": "metal metabolism disorder", "output": "An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals." }, { "input": "tonsillar fossa cancer", "output": "Malignant neoplasm of tonsillar fossa" }, { "input": "subacute sclerosing panencephalitis", "output": "A viral infectious disease that results_in infection located_in brain and that has_material_basis_in measles virus which is immune resistant." }, { "input": "autosomal dominant polycystic kidney disease", "output": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion." }, { "input": "narcolepsy", "output": "A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work." }, { "input": "choledochal cyst", "output": "A bile duct disease characterized by cystic dilation of one or more extrahepatic or intrahepatic bile ducts." }, { "input": "cervix uteri carcinoma in situ", "output": "An uterus carcinoma in situ that is located_in the uterine cervix." }, { "input": "polycythemia vera", "output": "A myeloproliferative neoplasm characterized by erythroid hyperplasia, myeloid leukocytosis, thrombocytosis, and splenomegaly." }, { "input": "degenerative disc disease", "output": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc." }, { "input": "hepatopulmonary syndrome", "output": "Hepatopulmonary syndrome" }, { "input": "sudden infant death syndrome", "output": "A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation." }, { "input": "psoriatic arthritis", "output": "An arthritis that is characterized by joint inflammation that usually occurs in combination with psoriasis." }, { "input": "liver lymphoma", "output": "A rare lymphoma that arises from the liver and the bulk of the tumor is located in the liver. the most frequent types of lymphoma that arise from the liver are diffuse large b-cell lymphoma and mucosa-associated lymphoid tissue lymphoma." }, { "input": "larynx carcinoma in situ", "output": "An in situ carcinoma that is located_in the larynx." }, { "input": "esophageal leukoplakia", "output": "A rare condition that usually affects the middle-to-distal esophagus in middle-aged and elderly people. there is usually a history of tobacco smoking or alcohol intake. dysphagia is the presenting symptom. morphologically, the lesions are well-demarcated and are characterized by epithelial hyperplasia, thickened basal layer, prominent granular cell layer, and hyperorthokeratosis. in a minority of patients this condition is associated with adjacent high-grade squamous dysplasia and/or squamous cell carcinoma." }, { "input": "intestine carcinoma in situ", "output": "An in situ carcinoma that is located_in the intestine." }, { "input": "gastrointestinal lymphoma", "output": "A non-hodgkin or hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site." }, { "input": "parotid gland cancer", "output": "A salivary gland cancer that is located_in the parotid gland." }, { "input": "polyp of corpus uteri", "output": "Polyp of corpus uteri" }, { "input": "uterine cervix leukoplakia", "output": "A cervix disease that is characterized by the presence of a hyperkeratotic lesion." }, { "input": "zellweger syndrome", "output": "A peroxisomal biogenesis disorder that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (pex) genes." }, { "input": "bladder carcinoma in situ", "output": "An in situ carcinoma that is located_in the bladder." }, { "input": "peroxisomal disease", "output": "An inherited metabolic disorder that involves peroxisome malfunction." }, { "input": "pityriasis versicolor", "output": "A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales." }, { "input": "ritter's disease", "output": "A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus staphylococcus (s. aureus). the infection has_symptom redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability." }, { "input": "leishmaniasis", "output": "A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus leishmania, which is transmitted by the bite of sand fly (subfamily phlebotominae)." }, { "input": "liver fibroma", "output": "A solitary fibrous tumor that arises from the liver. it affects females more frequently than males. signs and symptoms include the presence of an abdominal mass and abdominal discomfort." }, { "input": "lethal midline granuloma", "output": "Lethal midline granuloma" }, { "input": "systemic lupus erythematosus", "output": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart." }, { "input": "discoid lupus erythematosus of eyelid", "output": "Discoid lupus erythematosus of eyelid" }, { "input": "anal carcinoma in situ", "output": "An in situ carcinoma that is located_in the anus." }, { "input": "parapsoriasis", "output": "Parapsoriasis" }, { "input": "rem sleep behavior disorder", "output": "A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement." }, { "input": "esophagus carcinoma in situ", "output": "An in situ carcinoma that is located_in the esophagus." }, { "input": "erythematosquamous dermatosis", "output": "A skin condition that primarily affects the scalp and face and presents as scaly inflammation. examples include itchy, dry skin and dandruff." }, { "input": "sebaceous gland disease", "output": "A skin disease that is located_in the sebaceous gland." }, { "input": "occipital lobe neoplasm", "output": "Malignant neoplasm of occipital lobe" }, { "input": "uterus carcinoma in situ", "output": "An in situ carcinoma that is located_in the uterus." }, { "input": "cutaneous leishmaniasis", "output": "A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions." }, { "input": "granuloma inguinale", "output": "A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. the infection has_symptom painless genital ulcers." }, { "input": "acute myeloid leukemia", "output": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, { "input": "amyloidosis", "output": "A disease of metabolsism that is characterized by extracellular tissue deposition of mis-folded amyloid fibrils built up by twisted protofilaments, deposited in the spaces between the cells of vital organs, causing disruption of organ tissue structure and function. these deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition." }, { "input": "eczema herpeticum", "output": "A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in human herpesvirus 1 or human herpesvirus 2. the infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes." }, { "input": "lower gum cancer", "output": "Malignant neoplasm of lower gum" }, { "input": "atrophic muscular disease", "output": "A neuromuscular disease that is characterized by an abnormal reduction in the muscle volume and atrophy." }, { "input": "liver carcinoma in situ", "output": "An in situ carcinoma that is located_in the liver." }, { "input": "stomach carcinoma in situ", "output": "An in situ carcinoma that is located_in the stomach." }, { "input": "peliosis hepatis", "output": "Peliosis hepatis" }, { "input": "xeroderma of eyelid", "output": "Xeroderma of eyelid" }, { "input": "visceral leishmaniasis", "output": "A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. the symptoms include fever, weight loss, and an enlarged spleen and liver." }, { "input": "hard palate cancer", "output": "Malignant neoplasm of hard palate" }, { "input": "variola minor", "output": "A smallpox that results_in milder infection, located_in skin, has_material_basis_in variola virus. the infection results_in_formation_of lesions." }, { "input": "mucocutaneous leishmaniasis", "output": "A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa." }, { "input": "gas gangrene", "output": "A commensal bacterial infectious disease that results in infection, located in muscle tissue, has_material_basis_in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis." }, { "input": "liver benign neoplasm", "output": "A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma." }, { "input": "achalasia", "output": "An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing." }, { "input": "neurotic excoriation", "output": "Factitial dermatitis" }, { "input": "wiskott-aldrich syndrome", "output": "A syndrome that is characterized by abnormal immune system function and a reduced ability to form blood clots resulting from a decrease in the number and size of blood cell fragments involved in clotting (microthrombocytopenia)." }, { "input": "liver leiomyoma", "output": "A benign smooth muscle neoplasm arising from the liver. it is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern." }, { "input": "submandibular gland cancer", "output": "Malignant neoplasm of submandibular gland" }, { "input": "rectum carcinoma in situ", "output": "An in situ carcinoma that is located_in the rectum." }, { "input": "liver inflammatory pseudotumor", "output": "A multinodular intermediate fibroblastic neoplasm arising from the liver. it is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells." }, { "input": "amebiasis", "output": "A parasitic protozoa infectious disease that involves infection caused by the amoeba entamoeba histolytica. amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. the infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs." }, { "input": "pemphigus", "output": "An autoimmune disease of skin and connective tissue that is characterized by blistering of the outer layer of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals), causing lesions and blisters that are easily ruptured." }, { "input": "vestibule of mouth cancer", "output": "Malignant neoplasm of vestibule of mouth" }, { "input": "dyskinesia of esophagus", "output": "Dyskinesia of esophagus" }, { "input": "speech disorder", "output": "A communication disorder that involves difficulty with the act of speech production." }, { "input": "lichen planus", "output": "A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes." }, { "input": "barrett's esophagus", "output": "An esophageal disease characterized by a change of normal esophageal squamous epithelium to a columnar and intestinal-type epithelium." }, { "input": "periodic limb movement disorder", "output": "A sleep disorder that involves involuntary limb movement during sleep." }, { "input": "herpes zoster oticus", "output": "A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache." }, { "input": "pityriasis rubra pilaris", "output": "A skin disease that is characterized by hyperkeratotic follicular papules coalescing into orange-red scaly plaques, islands of sparing, and palmoplantar keratoderma." }, { "input": "central sleep apnea", "output": "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing." }, { "input": "pompholyx", "output": "A sweat gland disease that is characterized by recurrent vesicles and bullae that develop particularly upon the lateral palms, soles, and fingers and has_symptom pruritis and cracked skin." }, { "input": "kidney carcinoma in situ", "output": "An in situ carcinoma that is located_in the kidney." }, { "input": "pyriform sinus cancer", "output": "Malignant neoplasm of pyriform sinus" }, { "input": "erythromelalgia", "output": "A neuropathy that is characterized by intense, burning pain of affected extremities, severe redness and increased skin temperature." }, { "input": "alagille syndrome", "output": "A liver disease that is characterized by an accumulation of bile in the liver resulting from a reducted number of liver small bile ducts." }, { "input": "cerebral amyloid angiopathy", "output": "An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia." }, { "input": "pallister-hall syndrome", "output": "A syndrome that is characterized by hypothalamic hamartoma, pituitary dysfunction, central polydactyly, and visceral malformations and has_material_basis_in autosomal dominant heterozygous mutation in the gli3 gene on chromosome 7p14." }, { "input": "beemer-langer syndrome", "output": "A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly." }, { "input": "acrocallosal syndrome", "output": "A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation." }, { "input": "amino acid metabolic disorder", "output": "An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids." }, { "input": "gastrointestinal stromal tumor", "output": "Gastrointestinal stromal tumor" }, { "input": "mast-cell leukemia", "output": "A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood." }, { "input": "frontotemporal dementia", "output": "A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language." }, { "input": "colorectal cancer", "output": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, { "input": "waardenburg syndrome", "output": "A syndrome characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes." }, { "input": "nasopharynx carcinoma", "output": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract." }, { "input": "homocystinuria", "output": "An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine." }, { "input": "histidine metabolism disease", "output": "An amino acid metabolic disorder that involves deficiency in histidine." }, { "input": "cystinuria", "output": "An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder." }, { "input": "urea cycle disorder", "output": "An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream." }, { "input": "glycine encephalopathy", "output": "An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues." }, { "input": "maple syrup urine disease", "output": "An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures." }, { "input": "alkaptonuria", "output": "An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct." }, { "input": "ornithine carbamoyltransferase deficiency", "output": "An urea cycle disorder that involves a mutated and ineffective form of the enzyme ornithine transcarbamylase." }, { "input": "citrullinemia", "output": "An inherited urea cycle disorder that involves the accumulation of ammonia and other toxic substances in the blood." }, { "input": "hyperlysinemia", "output": "An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood." }, { "input": "tyrosinemia", "output": "An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine." }, { "input": "hyperargininemia", "output": "An urea cycle disorder that involves arginase deficiency resulting in elevated levels of plasma arginine." }, { "input": "hyperhomocysteinemia", "output": "An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood." }, { "input": "carbamoyl phosphate synthetase i deficiency disease", "output": "A urea cycle disorder that involves accumulation of ammonia in the blood." }, { "input": "phenylketonuria", "output": "An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (pah), rendering it nonfunctional." }, { "input": "ocular hypertension", "output": "An eye disease that is characterized by elevated intraocular pressure in the absence of optic nerve damage or visual field loss." }, { "input": "borderline glaucoma", "output": "A glaucoma characterized by clinical features and risk factors that are associated with high likelihood to developing optic atrophy secondary to glaucoma in the future. these features may include elevated intraocular pressure, retinal nerve fiber layer abnormalities, abnormal anterior chamber angles, and/or a positive family history for glaucoma without any evidence of current optic nerve atrophy." }, { "input": "priapism", "output": "A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain." }, { "input": "myopathy of extraocular muscle", "output": "Myopathy of extraocular muscles" }, { "input": "cleft lip", "output": "An orofacial cleft that is characterized by a congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences." }, { "input": "lip disease", "output": "A mouth disease located_in the lip." }, { "input": "myocardium cancer", "output": "A primary or metastatic malignant neoplasm that affects the myocardium." }, { "input": "language disorder", "output": "A communication disorder that involves the processing of linguistic information." }, { "input": "orbital disease", "output": "An adnexa disease that is located_in the eye socket." }, { "input": "neurofibroma of the heart", "output": "A rare neurofibroma that affects the heart." }, { "input": "splenic tuberculosis", "output": "An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen." }, { "input": "mechanical strabismus", "output": "Mechanical strabismus" }, { "input": "rectal prolapse", "output": "Rectal prolapse" }, { "input": "monieziasis", "output": "A parasitic helminthiasis infectious disease that involves zoonotic infection caused by moniezia expansa, the common tapeworm of sheep." }, { "input": "nasal cavity benign neoplasm", "output": "A respiratory system benign neoplasm that arises from the nasal cavity." }, { "input": "chronic ethmoiditis", "output": "A ethmoid sinusitis which lasts for 12 weeks or more." }, { "input": "lymphangitis", "output": "A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. it is caused by streptococcus pyogenes (group a strep) or staphylococcus aureus. lymphangitis is also sometimes called blood poisoning." }, { "input": "scotoma", "output": "Scotoma of blind spot area" }, { "input": "urethral false passage", "output": "Urethral false passage" }, { "input": "viral infectious disease", "output": "A disease by infectious agent that results in infection, has_material_basis_in viruses." }, { "input": "urethral diverticulum", "output": "Urethral diverticulum" }, { "input": "carotid artery dissection", "output": "Dissection of carotid artery" }, { "input": "diabetes mellitus", "output": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both." }, { "input": "type 2 diabetes mellitus", "output": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, { "input": "brain disease", "output": "A central nervous system disease that is located_in the brain." }, { "input": "intrinsic asthma", "output": "A chronic asthma that is triggered by factors not attributable to allergies." }, { "input": "status asthmaticus", "output": "An acute asthma that is characterized by an acute episode with a progressive severity that is poorly responsive to standard therapeutic measures, regardless of disease severity or phenotypic variant." }, { "input": "vesiculitis", "output": "Inflammatory disorders of seminal vesicle" }, { "input": "keratoconjunctivitis", "output": "Keratoconjunctivitis" }, { "input": "orbital plasma cell granuloma", "output": "Granuloma of orbit" }, { "input": "postural kyphosis", "output": "A kyphosis that has_material_basis_in slouching which results_in stretching of spinal ligament and abnormal formation located_in vertebra." }, { "input": "fuchs' heterochromic uveitis", "output": "A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface." }, { "input": "iridocyclitis", "output": "Primary iridocyclitis" }, { "input": "gonococcal iridocyclitis", "output": "Gonococcal iridocyclitis" }, { "input": "lens-induced iridocyclitis", "output": "Lens-induced iridocyclitis" }, { "input": "infectious anterior uveitis", "output": "Secondary infectious iridocyclitis" }, { "input": "tracheitis", "output": "A tracheal disease which involves bacterial infection of the trachea often caused by staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. the symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions." }, { "input": "croup", "output": "A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. the disease is caused by viruses, bacteria, allergies and inhaled irritants. it is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. croup is caused by parainfluenza virus (types 1 and 2), influenza a and b viruses, measles virus, adenovirus, respiratory syncytial virus, staphylococcus and streptococcus." }, { "input": "acute laryngitis", "output": "A laryngitis which lasts less than a few days." }, { "input": "epiglottitis", "output": "An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. haemophilus influenzae type b is the most common bacterial causative agent, although some cases are attributable to streptococcus pneumoniae or streptococcus pyogenes. the infection can cause the epiglottis to either obstruct or completely close off the windpipe. epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor." }, { "input": "epididymo-orchitis", "output": "Epididymo-orchitis" }, { "input": "epididymitis", "output": "Epididymitis" }, { "input": "hypopituitarism", "output": "A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland." }, { "input": "acute myocardial infarction", "output": "Acute myocardial infarction" }, { "input": "diabetes insipidus", "output": "A kidney disease that is characterized by polydipsia and polyuria with a dilute urine having a specific gravity less than 1.010, hypernatremia, and dehydration." }, { "input": "panhypopituitarism", "output": "A hypopituitarism characterized by deficiency in growth hormone and at least one other pituitary hormone." }, { "input": "allergic asthma", "output": "An extrinsic asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. the disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness." }, { "input": "blepharitis", "output": "An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow." }, { "input": "hypertensive encephalopathy", "output": "Hypertensive encephalopathy" }, { "input": "intracranial hypertension", "output": "A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has_symptom headache, has_symptom vomiting, has_symptom altered mental status, has_symptom papilledema." }, { "input": "chronic cholangitis", "output": "Cholangitis that is persistent and long-standing." }, { "input": "cervical mullerian papilloma", "output": "A cervical benign neoplasm that is a polypoid lesion of the superficial cervix or vagina of young girls to adult women and is characterized by papillary stalks covered by mucinous epithelium with focal squamous metaplasia, highly cellular fibrous tissue, no atypia, and minimal mitotic activity." }, { "input": "cervix squamous papilloma", "output": "A cervical benign neoplasm that is a polypoid lesion characterized by a single papillary frond with a central fibrovascular core and mature squamous epithelium." }, { "input": "cholangitis", "output": "A bile duct disease that is an inflammation of the bile duct." }, { "input": "steatotic liver disease", "output": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes." }, { "input": "lipid storage disease", "output": "A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues." }, { "input": "dientamoebiasis", "output": "A parasitic protozoa infectious disease that involves infection of the large intestine by a protozoan parasite dientamoeba fragilis. the symptoms include diarrhea, stomach pain and cramping, loss of appetite and weight, nausea, and fatigue." }, { "input": "uterine corpus cancer", "output": "A uterine cancer that is located_in the uterine corpus." }, { "input": "exposure keratitis", "output": "Exposure keratoconjunctivitis" }, { "input": "cholesteatoma of external ear", "output": "A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. it may develop spontaneously or as a consequence of infection, trauma or surgery." }, { "input": "otitis externa", "output": "An external ear disease that involves inflammation of the outer ear and ear canal. it can be caused by active bacterial or fungal infections." }, { "input": "nail-patella syndrome", "output": "A syndrome characterized by nail dysplasia and absent or hypoplastic patellae that has_material_basis_in heterozygous mutation in the lmx1b gene on chromosome 9q33.3." }, { "input": "bacterial meningitis", "output": "A meningitis that has_material_basis_in a bacterial infection." }, { "input": "meningitis", "output": "A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. it can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells." }, { "input": "sheehan syndrome", "output": "Hypopituitarism" }, { "input": "pulmonary embolism", "output": "An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot." }, { "input": "postpartum depression", "output": "An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth." }, { "input": "ulcerative blepharitis", "output": "Ulcerative blepharitis" }, { "input": "meckel's diverticulum", "output": "A physical disorder that is characterized by a congenital abnormality characterized by the outpouching or sac formation in the ileum." }, { "input": "chronic dacryoadenitis", "output": "Chronic dacryoadenitis" }, { "input": "pulmonary eosinophilia", "output": "A hypereosinophilic syndrome characterized by the accumulation of eosinophils in the lungs." }, { "input": "dacryoadenitis", "output": "Dacryoadenitis" }, { "input": "leukocyte disease", "output": "A hematopoietic system disease that is located_in white blood cells." }, { "input": "chronic eosinophilic pneumonia", "output": "An eosinophilic pneumonia which slowly progresses over weeks to months. life-threatening shortness of breath can develop if the condition is not treated. individuals are often diagnosed with asthma before the advent of this disease." }, { "input": "loeffler syndrome", "output": "An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. it can occur in response to a parasitic infection." }, { "input": "benign mammary dysplasia", "output": "A breast benign neoplasm that encompasses a range of conditions in which there is marked change in the breast tissue." }, { "input": "cannabis abuse", "output": "A substance abuse that involves the recurring use of cannabis despite negative consequences." }, { "input": "acute ethmoiditis", "output": "A ethmoid sinusitis which lasts for less than 4 weeks." }, { "input": "ethmoid sinusitis", "output": "A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead." }, { "input": "simple chronic conjunctivitis", "output": "Simple chronic conjunctivitis" }, { "input": "plasma cell leukemia", "output": "A plasma cell neoplasm that is characterized by the presence of a circulating clonal plasma cell count that exceeds 2x10^9/l or is 20% of the leukocyte differential count." }, { "input": "acute dacryoadenitis", "output": "Acute dacryoadenitis" }, { "input": "laron syndrome", "output": "A syndrome characterized by marked short stature with normal or high serum growth hormone and low serum insulin-like growth factor-1 levels that has_material_basis_in homozygous or compound heterozygous mutation in ghr on chromosome 5p13-p12." }, { "input": "latent syphilis", "output": "A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease." }, { "input": "tuberculous pneumothorax", "output": "A pneumothorax in which air enters into the pleural cavity." }, { "input": "lassa fever", "output": "A viral infectious disease that results_in infection, has_material_basis_in mammarenavirus lassaense, which is transmitted_by multimammate rat of the genus mastomys. the infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding." }, { "input": "multiple myeloma", "output": "A myeloid neoplasm that is located_in the plasma cells in bone marrow." }, { "input": "vascular skin disease", "output": "Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area." }, { "input": "refractory plasma cell neoplasm", "output": "A plasma cell neoplasm that is resistant to treatment." }, { "input": "indolent plasma cell myeloma", "output": "A multiple myeloma that is characterized by m protein in serum and/or urine and evidence of organ damage related the plasma cell neoplasm." }, { "input": "smoldering myeloma", "output": "A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody." }, { "input": "adrenal gland disease", "output": "An endocrine system disease that is located_in the adrenal gland." }, { "input": "peripheral nerve schwannoma", "output": "A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of schwann cells. it recurs infrequently and only rare cases associated with malignant transformation have been reported." }, { "input": "nasopharyngeal disease", "output": "Pathological processes involving the nasopharynx." }, { "input": "primary ciliary dyskinesia", "output": "A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, eustachian tube, middle ear) and fallopian tube." }, { "input": "bronchiectasis", "output": "A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances." }, { "input": "dextrocardia", "output": "Dextrocardia" }, { "input": "choanal atresia", "output": "Choanal atresia" }, { "input": "neonatal candidiasis", "output": "A candidiasis that involves fungal infection in neonates caused by candida species. low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates." }, { "input": "venezuelan equine encephalitis", "output": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in venezuelan equine encephalitis virus, which is transmitted_by culex mosquitoes. the infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region." }, { "input": "encephalitis", "output": "A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms." }, { "input": "urethral calculus", "output": "Calculus in urethra" }, { "input": "esophagus squamous cell papilloma", "output": "A rare neoplasm arising from the distal third of the esophagus. morphologically, it is characterized by the presence of fibrovascular cores covered by mature stratified squamous epithelium. progression to squamous cell carcinoma is extremely rare." }, { "input": "lower urinary tract calculus", "output": "A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone." }, { "input": "krukenberg carcinoma", "output": "An ovary epithelial cancer that is a metastatic signet-ring cell carcinoma, which spreads to the ovary from gastric tissue." }, { "input": "fasciitis", "output": "A connective tissue disease characterized by inflammation located in the fascia." }, { "input": "proliferative fasciitis", "output": "A rapidly growing, poorly circumscribed, mass-forming proliferation that arises from the subcutaneous tissues. it is characterized by the presence of spindle-shaped fibroblasts, round ganglion-like cells, myxoid to collagenous stroma formation, and high mitotic activity. it recurs only rarely following local excision and does not metastasize." }, { "input": "staphyloenterotoxemia", "output": "A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in staphylococcus aureus. the infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness." }, { "input": "esophagus leiomyoma", "output": "A benign smooth muscle neoplasm arising from the lower part of the esophagus. it is the most common mesenchymal neoplasm of the esophagus. dysphagia is a frequent clinical symptom." }, { "input": "plantar fasciitis", "output": "Plantar fascial fibromatosis" }, { "input": "ischemic fasciitis", "output": "A reactive, painless lesion which is characterized by a pseudosarcomatous proliferation of fibroblasts and myofibroblasts usually in the deep subcutaneous tissue. it occurs mainly around the limb girdles, sacral region, and greater trochanter. it affects mainly elderly patients and sometimes is associated with physical immobility. local excision is usually curative." }, { "input": "necrotizing fasciitis", "output": "Necrotizing fasciitis" }, { "input": "intravascular fasciitis", "output": "A rare self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the vessels. it is characterized by the presence of plump spindle-shaped fibroblasts, multinucleated osteoclast-like giant cells, chronic inflammatory infiltrate, red blood cell extravasation, and high mitotic activity." }, { "input": "neurofibroma of the esophagus", "output": "A non-metastasizing encapsulated neoplasm arising from nerves in the esophagus. morphologically, it is characterized by the presence of fibroblasts and schwann cells." }, { "input": "orthostatic proteinuria", "output": "Orthostatic proteinuria, unspecified" }, { "input": "neurofibroma", "output": "A moderately firm, benign, encapsulated tumor resulting from proliferation of schwann cells and fibroblasts that includes portions of nerve fibers. the tumors usually develop along peripheral or cranial nerves and are a central feature of neurofibromatosis 1, where they may occur intracranially or involve spinal roots. pathologic features include fusiform enlargement of the involved nerve. microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (from adams et al., principles of neurology, 6th ed, p1016)" }, { "input": "vesicoureteral reflux", "output": "A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter." }, { "input": "non-congenital cyst of kidney", "output": "Cyst of kidney, acquired" }, { "input": "kidney hypertrophy", "output": "Hypertrophy of kidney" }, { "input": "episodic ataxia", "output": "A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement." }, { "input": "pelger-huet anomaly", "output": "A hematopoietic system disease characterized by white blood cells with unusually shaped nuclei that has_material_basis_in heterozygous mutation in lbr on chromosome 1q42.12." }, { "input": "stomatitis", "output": "A mouth disease that is characterized by inflammation of the mouth and lips." }, { "input": "sarcocystosis", "output": "A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus sarcocystis. the symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy." }, { "input": "babesiosis", "output": "A parasitic protozoa infectious disease that has_symptom mild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus babesia, which reproduce in red blood cells and cause hemolytic anemia. they are transmitted by ixodid ticks or by blood transfusion. babesiosis is a zoonotic disease." }, { "input": "congenital nystagmus", "output": "A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction." }, { "input": "pathologic nystagmus", "output": "Nystagmus" }, { "input": "systolic heart failure", "output": "Unspecified systolic (congestive) heart failure" }, { "input": "oral mucosa leukoplakia", "output": "A mouth disease that is characterized by a white patch or plaque that develops in the oral cavity and is strongly associated with smoking." }, { "input": "aphthous stomatitis", "output": "A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers." }, { "input": "placental abruption", "output": "A placenta disease that is characterized by separation of the placental lining from the uterus of the mother." }, { "input": "senile cataract", "output": "A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging." }, { "input": "noma", "output": "Necrotizing ulcerative stomatitis" }, { "input": "ulcerative stomatitis", "output": "Other forms of stomatitis" }, { "input": "pulmonary emphysema", "output": "A chronic obstructive pulmonary disease that is characterized by permanent enlargement of air spaces distal to the terminal bronchioles and the destruction of the alveolar walls." }, { "input": "cervical incompetence", "output": "A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term." }, { "input": "yellow fever", "output": "A viral infectious disease that results in infection, has_material_basis_in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood." }, { "input": "toxic myocarditis", "output": "An acute myocarditis that is characterized by an underlying toxin insult to the myocardium that induces acute inflammation." }, { "input": "gonococcal keratitis", "output": "Gonococcal keratitis" }, { "input": "gonococcal endophthalmia", "output": "Other gonococcal eye infection" }, { "input": "ophthalmia neonatorum", "output": "A bacterial conjuctivitis that is characterized by pain and tenderness in the eyeball and conjuctival discharge." }, { "input": "tenosynovitis", "output": "Inflammation of the synovial lining of a tendon sheath. causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and achilles tendon. the tendon sheaths become inflamed and painful, and accumulate fluid. joint mobility is usually reduced." }, { "input": "bacterial conjunctivitis", "output": "Mucopurulent conjunctivitis" }, { "input": "rosacea conjunctivitis", "output": "Rosacea conjunctivitis" }, { "input": "tendinitis", "output": "Enthesopathy, unspecified" }, { "input": "occlusion of gallbladder", "output": "Obstruction of gallbladder" }, { "input": "hydrops of gallbladder", "output": "Hydrops of gallbladder" }, { "input": "neovascular inflammatory vitreoretinopathy", "output": "A retinal and vitreous disease characterized by ocular inflammation, vascular dropout, large spots of hyperpigmentation, neovascularization of the peripheral and posterior retina, vitreous hemorrhage, and retinal detachment that has_material_basis_in heterozygous mutation in the capn5 gene on chromosome 11q13.5." }, { "input": "vitreous disease", "output": "An eye and adnexa disease that is located in the vitreous of the eye." }, { "input": "ophthalmia nodosa", "output": "Ophthalmia nodosa" }, { "input": "vitreous abscess", "output": "A vitreous disease that is characterized by an abscess located_in the vitreous of the eye." }, { "input": "purulent endophthalmitis", "output": "Purulent endophthalmitis" }, { "input": "vitreous detachment", "output": "Vitreous degeneration" }, { "input": "renal tuberculosis", "output": "An urogenital tuberculosis that results_in formation of granulomas located_in kidney." }, { "input": "acute allergic mucoid otitis media", "output": "A blue drum syndrome caused by an allergen." }, { "input": "blue drum syndrome", "output": "A acute transudative otitis media involving thick, viscid and mucuslike fluid effusion due to which the drum appears blue in color." }, { "input": "eustachian tube disease", "output": "A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. it can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation." }, { "input": "upper respiratory tract disease", "output": "A respiratory system disease which involves the upper respiratory tract." }, { "input": "postcholecystectomy syndrome", "output": "A biliary tract disease characterized by the continuation or development of new gastrointestinal symptoms after cholecystectomy." }, { "input": "biliary tract disease", "output": "A hepatobiliary disease that is located_in the biliary tract." }, { "input": "pelvic varices", "output": "A varicose veins that is located_in the pelvis." }, { "input": "diabetic neuropathy", "output": "Peripheral, autonomic, and cranial nerve disorders that are associated with diabetes mellitus. these conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (vasa nervorum). relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see oculomotor nerve diseases); mononeuropathy; mononeuropathy multiplex; diabetic amyotrophy; a painful polyneuropathy; autonomic neuropathy; and thoracoabdominal neuropathy. (from adams et al., principles of neurology, 6th ed, p1325)" }, { "input": "type 1 diabetes mellitus", "output": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production." }, { "input": "perianal hematoma", "output": "Perianal venous thrombosis" }, { "input": "hemorrhoid", "output": "A pelvic varices that is characterized by swollen, inflamed veins around the anus or lower rectum." }, { "input": "internal hemorrhoid", "output": "A hemorrhoid that is located_in the rectum." }, { "input": "emphysematous cholecystitis", "output": "A cholecystitis consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues, where gallbladder wall necrosis causes gas formation in the lumen or wall." }, { "input": "xanthogranulomatous cholecystitis", "output": "A cholecystitis characterized by nodules containing lipid-laden macrophages." }, { "input": "myocardial stunning", "output": "Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity." }, { "input": "heart aneurysm", "output": "Aneurysm of heart" }, { "input": "transient neonatal thrombocytopenia", "output": "Transient neonatal thrombocytopenia" }, { "input": "female breast upper-outer quadrant cancer", "output": "A female breast cancer that is located_in the upper-outer quadrant of the breast." }, { "input": "diastolic heart failure", "output": "Unspecified diastolic (congestive) heart failure" }, { "input": "irritable bowel syndrome", "output": "An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause." }, { "input": "bowel dysfunction", "output": "Functional intestinal disorder, unspecified" }, { "input": "trichinosis", "output": "A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by trichinella spiralis, trichinella nativa or trichinella britovi. intestinal invasion causes diarrhea, abdominal pain and vomiting. larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. myocarditis, central nervous system involvement, and pneumonitis can also occur." }, { "input": "bulbar polio", "output": "A paralytic poliomyelitis that results in destruction located in motor neurons of brainstem, has_material_basis_in human poliovirus 1, has_material_basis_in human poliovirus 2, or has_material_basis_in human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. the infection has symptom difficulty breathing, has symptom difficulty speaking, has symptom difficulty swallowing, and has symptom difficulty chewing." }, { "input": "myositis fibrosa", "output": "Interstitial myositis" }, { "input": "toxocariasis", "output": "A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of toxocara canis or toxocara cati. the larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions." }, { "input": "hereditary choroidal atrophy", "output": "Hereditary choroidal dystrophy" }, { "input": "eye degenerative disease", "output": "Degenerated conditions of globe" }, { "input": "choroidal sclerosis", "output": "Unspecified choroidal degeneration" }, { "input": "tuberculous peritonitis", "output": "A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. the infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation." }, { "input": "goodpasture syndrome", "output": "An autoimmune disease that is characterized by antibody attack of the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure." }, { "input": "hypersensitivity vasculitis", "output": "A hypersensitivity reaction type iii disease that is characterized by inflammation and injury to blood vessels and has_symptom purpura, telangiectasia, blistering, urticaria, and ulcers." }, { "input": "diffuse secondary choroid atrophy", "output": "Diffuse secondary atrophy of choroid" }, { "input": "polyarteritis nodosa", "output": "A vasculitis that is characterized by necrotizing inflammation of medium or small arteries." }, { "input": "choroideremia", "output": "Choroideremia" }, { "input": "radioulnar synostosis", "output": "Other congenital malformations of upper limb(s), including shoulder girdle" }, { "input": "neonatal abstinence syndrome", "output": "A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment." }, { "input": "hyperopia", "output": "A refractive error that is characterized by rays of light entering the eye parallel to the optic axis are brought to a focus behind the retina, as a result of the eyeball being too short from front to back." }, { "input": "refractive error", "output": "Unspecified disorder of refraction" }, { "input": "hypertropia", "output": "Vertical strabismus" }, { "input": "cyclotropia", "output": "Cyclotropia" }, { "input": "accommodative esotropia", "output": "Accommodative component in esotropia" }, { "input": "esotropia", "output": "A strabismus that is characterized the eye which turns inward toward the nose." }, { "input": "hypotropia", "output": "Vertical strabismus in which there is permanent downward deviation of the visual axis of one eye." }, { "input": "monofixation syndrome", "output": "Monofixation syndrome" }, { "input": "peripheral vertigo", "output": "A vestibular disease that is characterized by a sensation of motion or spinning that is often described as dizziness due to a problem in the part of the inner ear that controls balance." }, { "input": "endolymphatic hydrops", "output": "M\u00e9ni\u00e8re's disease" }, { "input": "meniere's disease", "output": "A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss." }, { "input": "lingual-facial-buccal dyskinesia", "output": "Idiopathic orofacial dystonia" }, { "input": "congenital syphilis", "output": "A syphilis that results_in a multisystem infection in the fetus via the placenta." }, { "input": "interstitial keratitis", "output": "A connective tissue disease characterized by corneal scarring that develops from non-suppurative inflammation located_in the corneal stroma, has_symptom visual acuity loss, has_symptom pain, and has_symptom lacrimation." }, { "input": "deep keratitis", "output": "Interstitial and deep keratitis" }, { "input": "alopecia areata", "output": "An autoimmune disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots." }, { "input": "miliary tuberculosis", "output": "An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs." }, { "input": "toxic maculopathy", "output": "Toxic maculopathy" }, { "input": "intestinal disaccharidase deficiency", "output": "A classification of inherited or acquired disorders of sugar metabolism. deficiencies of lactase, maltase or sucrase-isomaltase usually occur irreversibly and independent of one another. congenital deficiencies are rare whereas acquired deficiencies are more common and may be seen following intestinal mucosal brush-border injury. clinical signs include abdominal cramping, bloating, flatulence and diarrhea following dietary intake of lactose, maltose or sucrose. the clinical course leads to malabsorption of disaccharides which has implications for normal growth and development if manifested at an early age." }, { "input": "hereditary fructose intolerance syndrome", "output": "A carbohydrate metabolic disorder characterized by recurrent vomiting, abdominal pain, and hypoglycemia that may be fatal after introduction of fructose or sucrose to the diet that has_material_basis_in homozygous or compound heterozygous mutation in the aldolase b gene (aldob) on chromosome 9q31." }, { "input": "alopecia", "output": "A hypotrichosis that is characterized by a loss of hair from the head or body." }, { "input": "galactosemia", "output": "A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues." }, { "input": "urethral gland abscess", "output": "Urethral abscess" }, { "input": "mitral valve prolapse", "output": "A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole." }, { "input": "cardiovascular syphilis", "output": "A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries." }, { "input": "becker muscular dystrophy", "output": "A muscular dystrophy that involves slowly worsening muscle weakness of the legs and pelvis, and has_material_basis_in x-linked recessive inheritance of mutation in the dystrophin gene on chromosome xp21." }, { "input": "muscular dystrophy", "output": "A myopathy is characterized by progressive skeletal muscle weakness degeneration." }, { "input": "alternating esotropia", "output": "Alternating esotropia" }, { "input": "median arcuate ligament syndrome", "output": "Celiac artery compression syndrome" }, { "input": "periodontosis", "output": "Periodontosis" }, { "input": "villonodular synovitis", "output": "Villonodular synovitis (pigmented), unspecified site" }, { "input": "congenital heart block", "output": "An atrioventricular block characterized by the presence of conduction system disease of any form, which is diagnosed on or before 28 days of life." }, { "input": "meibomian cyst", "output": "A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid." }, { "input": "follicular mucinosis", "output": "Alopecia mucinosa" }, { "input": "internal hordeolum", "output": "Hordeolum internum" }, { "input": "hordeolum", "output": "An eyelid disease that is characterized by an infection of the sebaceous glands at the base of the eyelashes. styes are generally caused by a staphylococcus aureus bacterial infection." }, { "input": "central corneal ulcer", "output": "A corneal ulcer that is characterized by ulceration and opacification of the central cornea and is caused by minor trauma and subsequent infection by bacterial or mycotic organisms." }, { "input": "infected hydrocele", "output": "Infected hydrocele" }, { "input": "omsk hemorrhagic fever", "output": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in omsk hemorrhagic fever virus, which is transmitted_by dermacentor and transmitted_by ixodes species of ticks. the infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum." }, { "input": "developmental coordination disorder", "output": "A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired." }, { "input": "waterhouse-friderichsen syndrome", "output": "An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland." }, { "input": "chronic inflammation of lacrimal passage", "output": "A lacrimal apparatus disease that is characterized by longstanding inflammation of the lacrimal passage, and has_symptom pain, increased or decreased tearing, and swelling between the eye and nose." }, { "input": "chronic canaliculitis", "output": "Chronic lacrimal canaliculitis" }, { "input": "chronic dacryocystitis", "output": "Chronic dacryocystitis" }, { "input": "dacryocystitis", "output": "An acute inflammation of lacrimal passage that is characterized by inflammation of the lacrimal sac, has_symptom conjunctivitis and has_symptom purulent discharge." }, { "input": "dacryocystocele", "output": "A congenital or acquired mucocele that develops in the lacrimal sac. it is usually the result of nasolacrimal duct abnormalities or obstruction." }, { "input": "lymph node disease", "output": "Any disorder of the lymph nodes." }, { "input": "constant exophthalmos", "output": "Constant exophthalmos" }, { "input": "steroid-induced glaucoma", "output": "A glaucoma characterized by elevated intraocular pressure secondary to chronic corticosteroid use, which leads to glaucomatous optic nerve atrophy and progressive vision loss and has_symptom progressive decreased vision, visual field defects, and decreased peripheral vision. steroid-induced glaucoma is caused by chronic corticosteroid use." }, { "input": "acute lymphoblastic leukemia", "output": "A acute leukemia that is characterized by over production of lymphoblasts." }, { "input": "acute biphenotypic leukemia", "output": "An acute leukemia that is characterized by the occurrence of more than one type of leukemia at the same time resulting from either the occurrence of blasts which coexpress myeloid and t or b lineage antigens or concurrent b and t lineage antigens." }, { "input": "hypoplastic left heart syndrome", "output": "A congenital heart disease characterized by abnormal development of the left-sided structures of the heart." }, { "input": "periostitis", "output": "A connective tissue disease characterized by inflammation located_in the periosteum of the bone." }, { "input": "hemometra", "output": "A uterine disease that is characterized by the presence of blood in the uterine cavity." }, { "input": "toxoplasmosis", "output": "A coccidiosis that has_material_basis_in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia." }, { "input": "carotenemia", "output": "An acquired metabolic disease that is characterized by yellow-orange skin pigmentation due to high levels of carotene in blood." }, { "input": "uterine inversion", "output": "A uterine disease that is characterized by the uterine cavity turning inside out as a complication of childbirth." }, { "input": "obesity", "output": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, { "input": "hypervitaminosis d", "output": "An overnutrition that is characterized by elevated vitamin d, which can subsequently cause high levels of calcium, has_symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has_material_basis_in excess intake of vitamin d." }, { "input": "hypervitaminosis a", "output": "An overnutrition that is characterized by excess vitamin a, has_symptom hepatomegaly, anorexia, fever, alopecia, and arthralgia, and has_material_basis_in excessive intake of vitaimin a, and/or derangement of vitamin a metabolism." }, { "input": "substance dependence", "output": "A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance." }, { "input": "drug dependence", "output": "A substance dependence that involves the continued use of drugs despite problems related to use of the substance." }, { "input": "cocaine dependence", "output": "A drug dependence that is a psychological dependency on the regular use of cocaine." }, { "input": "heroin dependence", "output": "An opiate dependence that involves the continued use of heroin despite problems related to use of the substance." }, { "input": "hallucinogen dependence", "output": "A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance." }, { "input": "acute female pelvic peritonitis", "output": "Female acute pelvic peritonitis" }, { "input": "eosinophilia-myalgia syndrome", "output": "A hypereosinophilic syndrome that is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration." }, { "input": "orbit lymphoma", "output": "An orbital cancer that has_material_basis_in some lymphocyte." }, { "input": "orbit sarcoma", "output": "An orbital cancer that has_material_basis_in abnormally proliferating cells derived from embryonic mesoderm." }, { "input": "tertiary neurosyphilis", "output": "A tertiary syphilis that results in infection located in brain or located in spinal cord." }, { "input": "hypereosinophilic syndrome", "output": "A leukocyte disease that is characterized by high numbers of eosinophils which over time enter various tissues, eventually damaging organs." }, { "input": "hypoglycemia", "output": "A glucose metabolism disease that is characterized by abnormally low levels of blood glucose." }, { "input": "peripartum cardiomyopathy", "output": "A dilated cardiomyopathy that is characterized by a weakness of the heart muscle that begins sometime during the final month of pregnancy through about five months after delivery." } ], "Categories": [ "Explanation" ], "Definition": [ "Assuming you are a doctor, please explan the following given medical professional entity for me." ] }