Hengzongshu/ArticleAgent huggingface dataset:
The NF-κB transcription factor controls the expression of genes responsible for cell cycle, apoptosis, and other immunoregulatory functions. Some nonspecific NF-κB inhibitors were found after discovering the possibility of blocking tumor growth through suppression of NF-κB activity, but their use was complicated by multiple side effects, such as interleukin-1β-related systemic inflammation or non-immunerelated complications, which may be due to inhibition of the p65 NF-κB subunit that plays a central role in organogenesis and inflammation. Inhibition of the c-Rel subunit leads to tumor growth restriction by modulating the T-regulatory cell activity. In 2017, Grinberg-Bleyer and co-authors checked the hypothesis that selective inhibition of the c-Rel subunit can be performed using pentoxifylline and will effectively regulate Treg activity during tumor growth. The authors showed that pentoxphylline, an FDA-approved drug, could indeed induce selective degradation of c-Rel without affecting p65, and suggested that such an effect could be effective in suppressing tumor growth.

In this regard, we aimed to investigate in vitro how pentoxifylline affect the functional activity and antitumor cytotoxic potential of T-cells in cancer patients. The objects of the study were peripheral blood mononuclear cells from 25 patients with primary breast cancer (no metastases), 15 patients with metastatic breast cancer, and 25 healthy women without breast pathology. Informed consent was obtained from all donors and patients. The study was approved by the local ethics committee.

Here we showed that pentoxifylline treatment in vitro enhances the pro-apoptotic and cytotoxic antitumor response via increasing the expression of TRAIL on T-lymphocytes, mainly in healthy donors and patients with metastatic breast cancer, both on intact T-cells and in response to the cells of the tumor line of human breast carcinoma ZR-75-1. In healthy donors, in the presence of pentoxifylline, a population of highly expressing TRAIL CD4 and CD8 T-cells appears.
Topological insulators (TIs) possess spin-polarized Dirac fermions on their surface but their unique properties are often masked by residual carriers in the bulk. Recently, (Sb 1− x Bi x ) 2 Te 3 was introduced as a non-metallic TI whose carrier type can be tuned from n to p across the charge neutrality point. By using time- and angle-resolved photoemission spectroscopy, we investigate the ultrafast carrier dynamics in the series of (Sb 1− x Bi x ) 2 Te 3 . The Dirac electronic recovery of ∼10 ps at most in the bulk-metallic regime elongated to >400 ps when the charge neutrality point was approached. The prolonged nonequilibration is attributed to the closeness of the Fermi level to the Dirac point and to the high insulation of the bulk. We also discuss the feasibility of observing excitonic instability of (Sb 1− x Bi x ) 2 Te 3 .
Spatio-temporal evolution of disturbance waves and ripple waves in annular gas-liquid flow was studied using high-speed modification of laser-induced fluorescence technique. Both flow regimes with and without entrainment were studied. It was shown that all the ripples in regimes with entrainment arise due to instability of back slopes of the disturbance waves, and their further evolution is predefined by the point of appearance. In regimes without entrainment two types of waves were detected, where waves of one type arise due to instability of back slopes of waves of the other type. Thus, similarity of wavy structure of flow regimes with and without entrainment was established.
In this study, single walled carbon nanotubes and reduced graphene oxide covalently and non-covalently functionalised by ZnPc were added to P3HT:PCBM blend in order to investigate the effects of these hybrid materials on P3HT:PCBM organic solar cell performance.
At present due to depletion of reserves in the majority of Western Siberia oil and gas fields, with reservoirs mainly related to lower Cretaceous and Jurassic section interval, the basement intervals present primary scientific and practical interest for prospecting and exploration. At the Bystrovka vibroseismic test site (Novosibirsk region), the Paleozoic basement occurs at depth of about 10 m. This allowed investigating its elastic properties with shallow seismic technique using VSP. Results of these investigations are presented in the present paper.
Ensuring the safety and high operation reliability of nuclear reactors takes 100% inspection of geometrical parameters of fuel assemblies, which include the grid spacers fabricated as cellular structure with fuel elements. The required grid spacers' geometry of assembly in the transverse and longitudinal cross sections is extremely important for maintaining the necessary heat regime.

A universal method for 3D grid spacer inspection using the diffractive optical element, which generates, as the structured light, a multiple-ring pattern on the inner surface of a grid spacer cell is investigated.

The experimental measurement error for cell centers position deviation is ±7 µm, and the error for overall dimensions is ±11 µm.
The paperexamines the attitude to uncertainty and risk withinthe Russian model of management by A.P. Prokhorov. It is shown that the attitudeis determined by the dual nature of this model. The Russian managementsystem in itsmobilization phase easily copes with the uncertainty and allows risky decisions. In the stable phase, the Russian model rejects risk, and security, understood as maintaining the achieved state, becomes a priority. A risky situation is a type of uncertain one when the occurrence of possible events is probable and can be estimated. In this situation, it is possible to assess the likelihood of events resulting from the influence of the natural environment, the actions of partners, opponents, etc., which cannot be done in a situationof uncertainty, and this is thekey factor that distinguishes between risk and uncertainty. Wedefine risk as an integral indicator that combines assessments of both the probabilities of implementing a solution and the quantitative characteristics of its consequences. Thus, risk management presupposes, first of all, a conscious and rational choice. Since changing the national model of management takes a lot of time, wesuggest to try to change the attitude to risk in modern Russian organizations.
Grammatical category of quantity is absent in the Japanese language but there are many different grammatical, lexical, derivational and morphological modes of expression of quantity. This paper provides an analysis of the lexical mode of expression of quantitative meanings and their semantics with the help of onomatopoeic (giongo) and mimetic (gitaigo) words in the Japanese language. Based on the analysis, we have distinguished the following semantic groups: mimetic words A) existence of some (large or small) quantity (things, phenomena and people), B) degree of change of quantity; and onomatopoeic words A) single sound, B) repetitive sounds.
The elliptic flow of prompt and non-prompt J/ψ was measured in the dimuon decay channel in Pb+Pb collisions at √sNN=5.02 TeV with an integrated luminosity of 0.42 nb⁻¹ with the ATLAS detector at the LHC.

The prompt and non-prompt signals are separated using a two-dimensional simultaneous fit of the invariant mass and pseudo-proper decay time of the dimuon system from the J/ψ decay. The measurement is performed in the kinematic range of dimuon transverse momentum and rapidity 9

It is found that prompt and non-prompt J/ψ mesons have non-zero elliptic flow. Prompt J/ψ v₂ decreases as a function of pT, while for non-prompt J/ψ it is, with limited statistical significance, consistent with a flat behaviour over the studied kinematic region. There is no observed dependence on rapidity or centrality.
In this manuscript we define Vassiliev measures of complexity for open curves in 3-space. These are related to the coefficients of the enhanced Jones polynomial of open curves in 3-space.

These Vassiliev measures are continuous functions of the curve coordinates and as the ends of the curve tend to coincide, they converge to the corresponding Vassiliev invariants of the resulting knot. We focus on the second Vassiliev measure from the enhanced Jones polynomial for closed and open curves in 3-space. For closed curves, this second Vassiliev measure can be computed by a Gauss code diagram and it has an integral formulation, the double alternating self-linking integral. The double alternating self-linking integral is a topological invariant for closed curves and a continuous function of the curve coordinates for open curves in 3-space.

For polygonal curves, the double alternating self-linking integral obtains a simpler expression in terms of geometric probabilities. For a polygonal curve with 4 edges, the double alternating self-linking integral coincides with the signed geometric probability of obtaining the knotoid k2.1 in a random projection direction.
Intensively evaporating liquid films shear-driven in a mini- or micro-channel under the action of cocurrent gas flow are promising for the use in modern cooling systems of semiconductor devices. In this work, we investigated the influence of liquid and gas flow rates on the critical heat flux in a locally heated film of water, moving under the action of air flow in a mini-channel. In experiments a record value of critical heat flux of 870 W/cm2 was reached. Heat spreading into the substrate and heat losses to the atmosphere in total do not exceed 25 % at heat fluxes above 400 W/cm2. A comparison with the critical heat flux for water flow boiling in the channel shows that, for shear-driven liquid films the critical heat flux is almost an order of magnitude higher.
Siberian silk moth (Dendrolimus superans sibiricus) is a very dangerous pest of coniferous trees, in particular, larch and various pine species. Outbreaks of this pest lead to defoliation and forest destruction in a vast area of the Asian part of Russia. Many biological agents, such as viruses, pathogenic microorganisms and parasitoids, prevent the growth of Siberian silk moth population.

Two samples from a Siberian silk moth population collected in 2014 and 2016 in Khabarovsk area were studied for Wolbachia infection. We found a high Wolbachia prevalence in the population of Siberian silk moth, in particular, the sample of 2014 was totally infected and the sample of 2016 had 90 % infected specimens. There were at least two distinct Wolbachia strains reveled by analysis of two loci from the MLST protocol, namely f tsZ-36, f bpA-4 and f tsZ-22, f bpA-9.

Here we consider non-pathogen symbiotic Wolbachia bacteria, which are transovarially transmitted between specimens from mother to offspring. This symbiont has an ability to affect biology of its host. In theory, Wolbachia can prevent the growth of population size or induce it, which determines the focus of interest in Wolbachia-host investigation. In this study, a possible role of Wolbachia in the symbiotic association with Siberian silk moth and general ways of investigation of this symbiosis are discussed.
Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Bacillius subtilis, Actinomyces viscosus and Escherichia coli bacterial strains. Coumarin-benzoic acid hybrids 4с, 42с and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin (29) showed promising activity against S. aureus strains, and the 1,2,3-triazolyloct-1-inyl linked coumarin-2,3-furocoumarin hybrid 37c was endowed with high selectivity against B. subtilis and E. coli species. The in vitro antibacterial activity of 4с, 29, 37c and 42с can potentially be compared with that of a number of modern antibiotic drugs used in the clinic, suggesting promising prospects for further research. A detailed study of the molecular interactions with the targeted protein MurB was performed using docking simulations and the obtained results are quite promising.
Correction for 'Na4Ca(CO3)3: a novel carbonate analog of borate optical materials' by Sergey V. Rashchenko et al., CrystEngComm, 2018, 20, 5228–5232.
Summary Using immunolocalization of MLH1, a mismatch repair protein that marks crossover sites along synaptonemal complexes, we estimated the total length of the genetic map, the recombination rate and crossover distribution in the American mink ( Mustela vison ). We prepared spreads from 130 spermatocytes of five male minks and mapped 3320 MLH1 foci along 1820 bivalents. The total recombination length of the male mink genome, based on the mean number of MLH1 foci for all chromosomes, was 1327 cM. The overall recombination rate was estimated to be 0.48 cM/Mb. In all bivalents, we observed prominent peaks of MLH1 foci near the distal ends and a paucity of them near the centromeres. This indicates that genes located at proximal regions of the chromosomes should display much tighter genetic linkage than physically equidistant markers located near the telomeres.
Исследование кристаллических аминокислот в условиях высоких давлений (как фазовых переходов, так и анизотропии деформации структуры в области устойчивости одной и той же фазы) позволяет лучше понять межмолекулярные взаимодействия и внутримолекулярную динамику в данных системах.Кристаллические аминокислоты используются как лекарственные препараты и подвергаются механическим воздействиям при таблетировании.Они рассматриваются как перспективные материалы благодаря нелинейным оптическим и пьезоэлектрическим свойствам.Наконец, кристаллические аминокислоты служат модельными объектами для изучения динамики биополимеров [1; 2].К настоящему времени исследовано влияние давления на несколько полиморфных модификаций глицина [3-9], Lи DL-формы серина [10-17], L-цистеин [18], L-аланин [19], L-аспарагин [20; 21], DL-валин [17], таурин [22], L-треонин [23], L-цистин [24].Представляет интерес не только варьировать боковые заместители в молекуле аминокислоты или сопоставлять влияние давле-
High-pressure research of the crystals of organic and coordination compounds is now a well-established field. However, the studies of multicomponent crystals (hydrates, solvates, salts and co-crystals) are just emerging.

The aim of this paper is to give a personal view of what makes the multicomponent organic systems peculiar for high-pressure research as compared with the monocomponent ones. Several different types of structure response to compression and reverse decompression are reviewed with examples based on research of salts, co-crystals and hydrates of amino acids.

Challenges and prospects of further studies are discussed.
The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti‐parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio of Pols α, δ and ϵ, with the assistance of Pol ζ and Y‐family Pols at difficult DNA template structures or sites of DNA damage. The parameters of the synthesis at a given location are dictated by the quality and quantity of nucleotides in the pools, replication fork architecture, transcription status, regulation of Pol switches, and structure of chromatin. The result of these transactions is a subject of survey and editing by DNA repair. Environ. Mol. Mutagen., 2012. © 2012 Wiley Periodicals, Inc.
This article presents new data on the properties of the diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotides d(TpCp*A) [1,2]. The data include information on isolation, identification, treatment with snake venom phosphodiesterase and structural analysis by 1D and 2D NMR spectroscopy and restrained molecular dynamics analysis. The data can be used for preparation, analysis, application of phosphoryl guanidine oligonucleotide and for development of new nucleic acids derivatives. This data article is associated with the manuscript titled "Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: isolation and properties" [1].
Drosophila melanogaster polytene chromosomes display specific banding pattern; the underlying genetic organization of this pattern has remained elusive for many years. In the present paper, we analyze 32 cytology-mapped polytene chromosome interbands. We estimated molecular locations of these interbands, described their molecular and genetic organization and demonstrate that polytene chromosome interbands contain the 5' ends of housekeeping genes. As a rule, interbands display preferential "head-to-head" orientation of genes. They are enriched for "broad" class promoters characteristic of housekeeping genes and associate with open chromatin proteins and Origin Recognition Complex (ORC) components. In two regions, 10A and 100B, coding sequences of genes whose 5'-ends reside in interbands map to constantly loosely compacted, early-replicating, so-called "grey" bands. Comparison of expression patterns of genes mapping to late-replicating dense bands vs genes whose promoter regions map to interbands shows that the former are generally tissue-specific, whereas the latter are represented by ubiquitously active genes. Analysis of RNA-seq data (modENCODE-FlyBase) indicates that transcripts from interband-mapping genes are present in most tissues and cell lines studied, across most developmental stages and upon various treatment conditions. We developed a special algorithm to computationally process protein localization data generated by the modENCODE project and show that Drosophila genome has about 5700 sites that demonstrate all the features shared by the interbands cytologically mapped to date.
Aim. The goal of the study was to analyze the differential expression of lipid metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis. Material and Methods. The study was performed on the specimens of atherosclerotic plaques in 45–65-year-old patients with coronary atherosclerosis with stable exertional angina functional class II-IV without acute coronary syndrome. Coronary atherosclerosis was verified by coronary angiography. Atherosclerotic plaque tissue was sampled intraoperatively when indicated. Whole-genome sequencing of ribonucleic acid (RNA) was performed using the TruSeq RNA Sample Preparation Kit (Illumina, USA). Results. We analyzed the differences in the expression of 12 genes including LDLR, APOB, PCSK9, LDLRAP1, LIPA, STAP1, ABCA1, APOA1, APOE, LPL, SCARB1 , and SREBF2 depending on the type of atherosclerotic plaques. The expression level of APOE gene was eight times higher in unstable atherosclerotic plaques of dystrophic-necrotic type ( p < 0.0001). The expression levels of LDLR and APOB genes were eight times higher in stable atherosclerotic plaques ( p < 0.0001). We did not find differences in the expression levels of the ABCG5, ABCG8, APOC3, CETP, CLPS, CYP7A1 , and PNPLA5 genes. Conclusion. The study showed the differences in the activity of individual metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis. Obtained data may become the basis for the development of test systems aimed at predicting the development of atherosclerotic process and its complications.
7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate.

Here we describe a study of 7-MG inhibition mechanism using molecular dynamics, fluorescence anisotropy and single-particle Förster resonance energy transfer (spFRET) microscopy approaches to elucidate intermolecular interactions between 7-MG, PARP-1 and nucleosomal DNA. It is shown that 7-MG competes with substrate NAD+ and its binding in the PARP-1 active site is mediated by hydrogen bonds and nonpolar interactions with the Gly863, Ala898, Ser904, and Tyr907 residues.

7-MG promotes formation of the PARP-1–nucleosome complexes and suppresses DNA-dependent PARP-1 automodification. This results in nonproductive trapping of PARP-1 on nucleosomes and likely prevents the removal of genotoxic DNA lesions.
There are evidences that obese women exhibit a detrimental oocyte quality. However, it remains unclear how this change is associated with obesity, indirectly – or directly through a change in the content and/or composition of lipids in oocytes.

The aim of this work was to study effects of a high-fat diet applied to female donor mice on the amount and qualitative composition of lipids of immature and in vivo matured oocytes. A high-fat diet caused larger body weight in female mice compared with the control (p < 0.001; 44.77±1.46 and 35.22±1.57, respectively), and increased the blood levels of cholesterol (p < 0.05; 2.06±0.10 and 1.78±0.10, respectively) and triglycerides (p < 0.05; 2.13±0.23 and 1.49±0.21, respectively). At the same time, this diet does not affect the level of unsaturation of lipids in immature (0.207±0.004 in the experiment and 0.206±0.002 in the control) and matured oocytes (0.212±0.005 in the experiment and 0.211±0.003 in the control).

Total lipid content increased during in vivo maturation of mouse oocytes. The amount of lipids was greater in mature oocytes in the experimental group compared to the control (p < 0.01; 8.15±0.37 and 5.83±0.14, respectively). An increase in intracellular lipid amount during oocyte maturation was revealed both after a standard diet (p < 0.05; 4.72±0.48 and 5.83±0.14, respectively) and after a fat-rich diet (p < 0.001; 3.45±0.62 and 8.15±0.37, respectively). Thus, during in vivo oocyte maturation in mice the content of intracellular lipids enhanced, the high-fat diet aggravated this dynamics of lipid increase during in vivo maturation of oocytes.
We report a hitherto undiscovered frequency shift for forbidden J = 0-->J = 0 clock transitions excited in atoms confined to an optical lattice. These shifts result from magnetic-dipole and electric-quadrupole transitions, which have a spatial dependence in an optical lattice that differs from that of the stronger electric-dipole transitions. In combination with the residual translational motion of atoms in an optical lattice, this spatial mismatch leads to a frequency shift via differential energy level spacing in the lattice wells for ground state and excited state atoms. We estimate that this effect could lead to fractional frequency shifts as large as 10(-16), which might prevent lattice-based optical clocks from reaching their predicted performance levels. Moreover, these effects could shift the magic wavelength in lattice clocks in three dimensions by as much as 100 MHz, depending on the lattice configuration.
The review of the studies of GaAs and GaN surfaces performed by the authors at the Institute of Semiconductor Physics (Novosibirsk) are presented. The results of these studies are used for further elucidation of the physics of photoemission from the surfaces with negative electron affinity (NEA) and improving the performance of NEA-photocathodes.

To meet these requirements, the experimental procedures aimed at preparing atomically clean and flat surfaces with certain reconstructions, which are subsequently activated to the state of NEA in ultra-high vacuum by coadsorption of cesium and oxygen, are developed.

The surface morphological, structural, and electronic phenomena occurring on various stages of these preparation procedures are studied, and the relation of these phenomena to the physical limits of NEA-photocathode performance are discussed.