Hengzongshu/ArticleAgent huggingface dataset:
The idea that chaotic set of quantum vortices can mimic classical turbulence, or at least reproduce many main features, is currently actively being developed. Appreciating significance of the challenging problem of the classical turbulence it can be expressed that the idea to study it in terms of quantized line is indeed very important and may be regarded as a breakthrough. For this reason, this theory should be carefully scrutinized. One of the basic arguments supporting this point of view is the fact that vortex tangle decays at zero temperature, when the apparent mechanism of dissipation (mutual friction) is absent. Since the all possible mechanisms of dissipation of the vortex energy, discussed in the literature, are related to the small scales, it is natural to suggest that the Kolmogorov cascade takes the place with the flow of the energy, just as in the classical turbulence. In a series of recent experiment attenuation of vortex line density was observed and authors attribute this decay to the properties of the Kolmogorov turbulence.

In the present work we discuss alternative possibility of decay of the vortex tangle, which is not related to dissipation at small scales. This mechanism is just the diffusive like spreading of the vortex tangle.

We discuss a number of the key experiments, considering them both from the point of view of alternative explanation and of the theory of Kolmogorov turbulence in quantum fluids.
ИЗМЕРЕНИЕ ИОНИЗАЦИОННЫХ ВЫХОДОВ ЯДЕР ОТДАЧИ В ЖИДКОМ АРГОНЕ

С ПОМОЩЬЮ ДВУХФАЗНОГО ДЕТЕКТОРА С ОПТИЧЕСКИМ СЧИТЫВАНИЕМ
Cave sites often become objects of palynological reconstructions; however, the question of the representativeness of cave deposits for palynological researches in connection with the specifics of the distribution and burial of pollen grains in the caves is currently relevant and insufficiently studied.

This article provides the results of a palynological study of surface samples from three sites: Strashnaya, Chagyrskaya, and Biyka-1 caves (Altai Territory). The comparison of the results based on the study of samples inside and outside the caves showed their similarity, which confirms the assumption that such data can be used for climatic reconstructions.

However, there are aspects necessary to be taken into consideration when interpreting palynological data obtained from the deposits of cave sites, which is also confirmed by other researchers. Such aspects include the following: location of the sampling site: there is a negative correlation between the distance from the cave entrance and the concentration of pollen, as well as the content of anemophilic plants pollen in a sample; animal activity inside the cave: animal roosting and denning behavior or insect nesting inside the cave may cause distortion of palinospectra; cave morphology, size and number of cave entrances: it was noted that caves with one sufficiently wide entrance are more indicative, because it can provide sufficient air circulation in the cave; orientation of the cave entrances: palinospectra inside the cave may reflect the local vegetation of the territory to which the entrance is directed; specificity of the distribution of pollen grains of plants of various families: it was noted that the accumulation of pollen of entomophilic plants closer to the back of the cave is higher than anemophilic ones; different degree of resistance of the shells of pollen grains of different families: pollen grains with a shell more resistant to post-deposition processes may be present in palinospectra in greater concentration due to the destruction of grains with a less resistant shell.
To assess the outcomes of myocardial revascularization (MR) and identify risk factors for early postoperative complications in patients with coronary artery disease (CAD) with acute coronary syndrome (ACS) in the context of coronavirus disease 2019 (COVID-19) pandemic.

The study included 769 patients aged 67,0±4,4 years with CAD with ACS in the period from April to October 2020. In an expedited manner, percutaneous transluminal coronary angioplasty (n=699) and on pump coronary artery bypass grafting (CABG) (n=70) were performed. All patients underwent a COVID-19 rapid tests. After MR, the following outcomes were recorded: adverse cardiovascular events and other complications; various surgical interventions; bilateral COVID-19 pneumonia; death. The follow-up period lasted 30 days.

During the hospitalization, COVID-19 was detected in 5,3% of patients (n=41). Among them, bilateral multisegmental pneumonia developed in 48,8%. Among infected patients, COVID-19-related mortality in the early postoperative period was 9,8%. The all-cause mortality rate was 0,7%. On pump CABG significantly increases the risk of developing COVID-19 pneumonia (odds ratio (OR), 23,2; 95% confidence interval (CI) 14,2-35,4; p<0,001). After MR, COVID-19 pneumonia was associated with respiratory (OR, 7,6; 95% CI, 4,3-11,5; p=0,001) and heart failure (OR, 4,2; 95% CI, 2,9-8,6; p=0,001), atrial fibrillation (OR, 8,3; 95% CI, 4,1-13,9; p=0,001), as well as with all-cause mortality (OR, 10,3; 95% CI, 5,2-16,7; p=0,005). Recurrent transmural myocardial infarction in patients with CAD was associated with heart failure after MR (OR, 7,1; 95% CI, 2,4-12,6; p=0,012). Conducting on pump CABG in patients with CAD with ACS is the leading trigger for developing COVID-19 pneumonia, which, during hospitalization after MR, was associated not only with respiratory complications, but also with impaired heart function, which significantly increases the death risk in this category of patients.
The results of numerical experiments on the modeling of shock wave loading of solid and porous carbides with various stoichiometric compositions are presented.

The model is based on the assumption that all the components of the mixture, including gas, have similar pressure, velocity and temperature. The model allows describing the behavior of porous materials and mixes in a wide range of porosity and pressures with precision of experiment. The behavior of complex materials such as carbides is considered as a mixture.

The model accurately describes the behavior of the carbides with equal shares of the components of WC, TiC, TaC, NbC and the behavior of boron carbide B 4 C. Comparison for data of calculation and experimental data was held for carbides with different porosity.
Aim . To study association between polymorphisms of candidate genes and the development of non-infectious and infectious endocarditis (IE). Material and methods . During the study 175 patients were examined. They were divided into two groups: the first group — 81 patients with non-infectious endocarditis and the second one — 94 patients with IE. We present a comparative analysis of the genotype frequencies of the five genes polymorphisms: rs11697325 (-8202 A/G) of the MMP9 gene, 4a/4b of the NOS3 gene, rs4340 of the ACE gene, rs2476601 (С1858Т) of the PTPN22 gene, rs231775 (49 A/G) of the CTLA4 gene in groups of patients with endocarditis and healthy individuals. Results . We found association between endocarditis and rs11697325 (-8202 A/G) of the MMP9 gene, 4a/4b of the NOS3 gene, as well as rs2476601 (C1858T) of the PTPN22 gene with IE. Conclusion . Thus, association between three of the five polymorphisms and vegetations on the valvular heart apparatus was revealed.
Les dictionnaires d'associations évoquées par les mots sont créés à partir de la collecte des réactions données à un stimulus lexical (500 réactions au moins par stimulus). La plupart de ces réactions s'explique par des relations logiques basées sur le sens du stimulus proposé.

Nous analyserons ici cette catégorie de réactions pour en proposer une typologie : le jeu peut consister en un simple écho (homonyme ou paronyme) du stimulus, soit c'est l'association des deux qui est ludique. Nous analysons les cas douteux, qui peuvent être dus à une lecture erronée du stimulus ou une orthographe douteuse de la réaction.

discuterons du bien-fondé de la prise en compte des jeux de mots dans le dictionnaire d'associations, dont le principe est d'être formé de réactions spontanées au stimulus, tandis qu'un jeu de mot suppose une réflexion, si courte soit-elle.
The evolution of mechanical properties of Russian steel St3 subjected to cyclic elasto-plastic deformation is analyzed under a broad spectrum of loading conditions. This particular material is chosen due to its wide use in industrial facilities operating in Arctic and Russian North. Basic state parameters are determined, including the true strains, secant and tangent moduli, heat generation due to plastic dissipation, thus characterizing the evolution of the thermo-mechanical state. The temporal evolution of kinetic parameters during each loading block provides insights into the hardening and damage accumulation. These data form an experimental basis for development, calibration, and validation of new material models. The main effects are identified and discussed, and the modelling approaches are assessed.
Small non-coding RNAs have gained substantial attention due to their roles in animal development and human disorders. Among them, microRNAs are special because individual gene sequences are conserved across the animal kingdom. In addition, unique and mechanistically well understood features can clearly distinguish bona fide miRNAs from the myriad other small RNAs generated by cells. However, making this distinction is not a common practice and, thus, not surprisingly, the heterogeneous quality of available miRNA complements has become a major concern in microRNA research.

We addressed this by extensively expanding our curated microRNA gene database - MirGeneDB - to 45 organisms, encompassing a wide phylogenetic swath of animal evolution. By consistently annotating and naming 10,899 microRNA genes in these organisms, we show that previous microRNA annotations contained not only many false positives, but surprisingly lacked >2000 bona fide microRNAs.

Indeed, curated microRNA complements of closely related organisms are very similar and can be used to reconstruct ancestral miRNA repertoires. MirGeneDB represents a robust platform for microRNA-based research, providing deeper and more significant insights into the biology and evolution of miRNAs as well as biomedical and biomarker research.
Obesity and diabetes mellitus are known to lead to the development of metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The mechanisms of programmed cell death are actively involved in maintaining cellular homeostasis along development of NAFLD. Proteins of the BCL-2 family are key regulators of physiological and pathological apoptosis. Homozygous males of BKS.Cg-Dock7 m Lepr db /+/+/J mice ( db/db mice) are characterized by progressive obesity and the development of type 2 diabetes mellitus (DM2) with severe hyperglycemia at 4–8 weeks and organ lesions at 8–10 weeks of age. The aim of this research was to study the expression of molecular cell regulators of apoptosis in liver cells of db/db mice males at different stages of obesity and diabetes development (at the age of 10 and 18 weeks). Immunohistochemical analysis (using the indirect avidin-biotin peroxidase method) and morphometric evaluation of the expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bad in liver cells of studied animals at different stages of obesity and DM2 were carried out. An excess of the value of the Bcl-2 protein staining area over the Bad protein staining area was revealed in the liver of 10-week-old animals. The Bcl-2/Bad expression area ratio in 10-week-old animals was twice as high as in 18-week-old animals, which indicates the presence of conditions for blocking apoptosis in the liver of younger db/db mice. At the 18th week of life, db/db mice displayed an almost threefold increase in the expression area of the Bad protein against the background of an unchanged expression of the Bcl-2 protein. The decrease in the Bcl-2/Bad staining area ratio in 18-week-old animals was due to the increase in the Bad expression area, which indicates the absence of antiapoptotic cell protection and creates conditions for activation of the mitochondrial pathway of apoptosis in the liver of male db/db mice with pronounced signs of obesity and DM2.
Computational modelling of mammalian cell cycle regulation is a challenging task, which requires comprehensive knowledge on many interrelated processes in the cell.

We have developed a web-based integrated database on cell cycle regulation in mammals in normal and pathological states (Cyclonet database). It integrates data obtained by 'omics' sciences and chemoinformatics on the basis of systems biology approach. Cyclonet contains information on relevant genes and molecules; diagrams and models of cell cycle regulation and results of their simulation; microarray data on cell cycle and on various types of cancer, information on drug targets and their ligands, as well as extensive bibliography on modelling of cell cycle and cancer-related gene expression data. The Cyclonet database is also accessible through the BioUML workbench, which allows flexible querying, analyzing and editing the data by means of visual modelling.

Cyclonet aims to predict promising anticancer targets and their agents by application of Prediction of Activity Spectra for Substances. Cyclonet is a specialized resource, which enables researchers working in the field of anticancer drug discovery to analyze the wealth of currently available information in a systematic way. The Cyclonet database is available at http://cyclonet.biouml.org.
This article presents a study of bound periodically oscillating coherent structures arising on the free surface of deep water. Such structures resemble the well known bi-soliton solution of the nonlinear Schrödinger equation. The research was carried out in the super-compact Dyachenko-Zakharov equation model for unidirectional deep water waves and the full system of nonlinear equations for potential flows of an ideal incompressible fluid written in conformal variables. The special numerical algorithm that includes a damping procedure of radiation and velocity adjusting was used for obtaining such bound structures. The results showed that in both nonlinear models for deep water waves after the damping is turned off, a periodically oscillating bound structure remains on the fluid surface and propagates stably over hundreds of thousands of characteristic wave periods without losing energy.
The results of physical modeling show that the influence of boundary roughness on its reflectivity depends on the ratio of roughness characteristic dimension and wavelength.

The boundary roughness leads to a decrease in the effective reflection coefficients at subcritical and to their increase at supercritical angles of incidence. A change in the azimuth of the plane of incidence with respect to the roughness direction appreciably affects the reflection coefficients only at supercritical angles.
We show that a sufficient condition for the weak limit of a sequence of $W^1_q$-homeomorphisms with finite distortion to be almost everywhere injective for $q \geq n-1$, can be stated by means of composition operators.

Applying this result, we study nonlinear elasticity problems with respect to these new classes of mappings.

Furthermore, we impose loose growth conditions on the stored-energy function for the class of $W^1_n$-homeomorphisms with finite distortion and integrable inner as well as outer distortion coefficients.
Theauxin efflux carrier PIN1 is a key mediator of polar auxin transport in developing plant tissues. This is why factors that are supposed to be involved in auxin distribution are frequently tested in the regulation of PIN1 expression. As a result, diverse aspects of PIN1 expression are dispersed across dozens of papers entirely devoted to other specific topics related to the auxin pathway. Integration of these puzzle pieces about PIN1 expression revealed that, along with a recurring pattern, some features of PIN1 expression varied from article to article.

To determine if this uncertainty is related to the specific foci of articles or has a basis in the variability of PIN1 gene activity, we performed a comprehensive 3D analysis of PIN1 expression patterns in Arabidopsis thaliana roots. We provide here a detailed map of PIN1 expression in the primary root, in the lateral root primordia and at the root-shoot junction. The variability in PIN1 expression pattern observed in individual roots may occur due to differences in auxin distribution between plants. To simulate this effect, we analysed PIN1 expression in the roots from wild type seedlings treated with different IAA concentrations and pin mutants.

Most changes in PIN1 expression after exogenous IAA treatment and in pin mutants were also recorded in wild type but with lower frequency and intensity. Comparative studies of exogenous auxin effects on PIN1pro:GUS and PIN1pro:PIN1-GFP plants indicated that a positive auxin effect is explicit at the level of PIN1 promoter activity, whereas the inhibitory effect relates to post-transcriptional regulation. Our results suggest that the PIN1 expression pattern in the root meristem accurately reflects changes in auxin content. This explains the variability of PIN1 expression in the individual roots and makes PIN1 a good marker for studying root meristem activity.
We analyzed the whole-genome experimental maps of nucleosomes in Drosophila melanogaster and classified genes by the expression level in S2 cells (RPKM value, reads per kilobase million) as well as the number of tissues in which a gene was expressed (breadth of expression, BoE). Chromatin in 5′-regions of genes we classified on four states according to the hidden Markov model (4HMM). Only the Aquamarine chromatin state we considered as Active, while the rest three states we defined as Non-Active.

We analyzed the whole-genome experimental maps of nucleosomes in Drosophila melanogaster and classified genes by the expression level in S2 cells (RPKM value, reads per kilobase million) as well as the number of tissues in which a gene was expressed (breadth of expression, BoE). Chromatin in 5′-regions of genes we classified on four states according to the hidden Markov model (4HMM).

Surprisingly, about 20/40% of genes with 5′-regions mapped to Active/Non-Active chromatin possessed the minimal/at least modest RPKM and BoE. We found that regardless of RPKM/BoE the genes of Active chromatin possessed the regular nucleosome arrangement in 5′-regions, while genes of Non-Active chromatin did not show respective specificity. Only for genes of Active chromatin the RPKM/BoE positively correlates with the number of nucleosome sites upstream/around TSS and negatively with that downstream TSS. We propose that for genes of Active chromatin, regardless of RPKM value and BoE the nucleosome arrangement in 5′-regions potentiates transcription, while for genes of Non-Active chromatin, the transcription machinery does not require the substantial support from nucleosome arrangement to influence gene expression.
The Char suture–shear zone in East Kazakhstan is located in the north-western Central Asian Orogenic Belt (CAOB). The Char tonalites and plagiogranites occur as NW-striking linear chains inside Visean serpentinite mélange.

The study included analysis of geological setting, major and trace elements, and rock petrogenesis. Petrographycally, the tonalites show signs of syntectonic deformation, and the plagiogranites are less deformed suggesting their later intrusion. The tonalites yielded a LA-ICP-MS zircon age of ca. 323 Ma. Compositionally, the tonalites and plagiogranites are characterized by high SiO2 and Al2O3, Sr/Y > 40 and low Yb. Their multi-element patterns show clear Nb-Ta negative anomalies. The low Nb/Ta ratios and Zr suggest a MORB-type protolith with subchondritic Nb/Ta and low Zr. The low contents of K and Rb suggest weak assimilation of the melts by island arc felsic crust.

The subchondritic Nb/Ta ratios exclude their derivation by the melting of subducted/dehydrated MORB. We argue that the Char high-Al tonalites and plagiogranites formed by the melting of hydrated MORB at the base of the mafic lower crust at pressures of 10–15 kbar. Their geochemical features suggest their origin by the melting of mafic lower crust in relation to the collision of the Siberian and Kazakhstan continents.
This paper presents a study of the interaction of liquid microdroplets falling on a solid surface whose temperature is varied from 75 °C to 155 °C.

It has been shown for the first time that droplet levitation above a solid surface is possible at a temperature below the saturation temperature.

It has been found that for levitated droplets, the specific evaporation rate is constant in time, but for sessile droplets, it increases sharply. The evaporation rate for sessile droplet was found an order of magnitude higher than that for levitated droplets.
Denham Harman's oxidative damage theory identifies superoxide (O2•-) radicals as central agents of aging and radiation injury, with Mn2+-dependent superoxide dismutase (MnSOD) as the principal O2•--scavenger. However, in the radiation-resistant nematode Caenorhabditis elegans, the mitochondrial antioxidant enzyme MnSOD is dispensable for longevity, and in the model bacterium Deinococcus radiodurans, it is dispensable for radiation resistance. Many radiation-resistant organisms accumulate small-molecule Mn2+-antioxidant complexes well-known for their catalytic ability to scavenge O2•-, along with MnSOD, as exemplified by D. radiodurans. Here, we report experiments that relate the MnSOD and Mn-antioxidant content to aging and oxidative stress resistances and which indicate that C. elegans, like D. radiodurans, may rely on Mn-antioxidant complexes as the primary defense against reactive oxygen species (ROS). Wild-type and ΔMnSOD D. radiodurans and C. elegans were monitored for gamma radiation sensitivities over their life spans while gauging Mn2+-antioxidant content by electron paramagnetic resonance (EPR) spectroscopy, a powerful new approach to determining the in vivo Mn-antioxidant content of cells as they age. As with D. radiodurans, MnSOD is dispensable for radiation survivability in C. elegans, which hyperaccumulates Mn-antioxidants exceptionally protective of proteins. Unexpectedly, ΔMnSOD mutants of both the nematodes and bacteria exhibited increased gamma radiation survival compared to the wild-type. In contrast, the loss of MnSOD renders radiation-resistant bacteria sensitive to atmospheric oxygen during desiccation. Our results support the concept that the disparate responses to oxidative stress are explained by the accumulation of Mn-antioxidant complexes which protect, complement, and can even supplant MnSOD. IMPORTANCE The current theory of cellular defense against oxidative damage identifies antioxidant enzymes as primary defenders against ROS, with MnSOD being the preeminent superoxide (O2•-) scavenger. However, MnSOD is shown to be dispensable both for radiation resistance and longevity in model organisms, the bacterium Deinococcus radiodurans and the nematode Caenorhabditis elegans. Measured by electron paramagnetic resonance (EPR) spectroscopy, small-molecule Mn-antioxidant content was shown to decline in unison with age-related decreases in cell proliferation and radioresistance, which again are independent of MnSOD presence. Most notably, the Mn-antioxidant content of C. elegans drops precipitously in the last third of its life span, which links with reports that the steady-state level of oxidized proteins increases exponentially during the last third of the life span in animals. This leads us to propose that global responses to oxidative stress must be understood through an extended theory that includes small-molecule Mn-antioxidants as potent O2•--scavengers that complement, and can even supplant, MnSOD.