Hengzongshu/ArticleAgent huggingface dataset:
Aggressiveness in humans is a hereditary behavioral trait that mobilizes all systems of the body—first of all, the nervous and endocrine systems, and then the respiratory, vascular, muscular, and others—e.g., for the defense of oneself, children, family, shelter, territory, and other possessions as well as personal interests. The level of aggressiveness of a person determines many other characteristics of quality of life and lifespan, acting as a stress factor. Aggressive behavior depends on many parameters such as age, gender, diseases and treatment, diet, and environmental conditions. Among them, genetic factors are believed to be the main parameters that are well-studied at the factual level, but in actuality, genome-wide studies of aggressive behavior appeared relatively recently. One of the biggest projects of the modern science—1000 Genomes—involves identification of single nucleotide polymorphisms (SNPs), i.e., differences of individual genomes from the reference genome. SNPs can be associated with hereditary diseases, their complications, comorbidities, and responses to stress or a drug. Clinical comparisons between cohorts of patients and healthy volunteers (as a control) allow for identifying SNPs whose allele frequencies significantly separate them from one another as markers of the above conditions. Computer-based preliminary analysis of millions of SNPs detected by the 1000 Genomes project can accelerate clinical search for SNP markers due to preliminary whole-genome search for the most meaningful candidate SNP markers and discarding of neutral and poorly substantiated SNPs. Here, we combine two computer-based search methods for SNPs (that alter gene expression) {i} Web service SNP_TATA_Comparator (DNA sequence analysis) and {ii} PubMed-based manual search for articles on aggressiveness using heuristic keywords. Near the known binding sites for TATA-binding protein (TBP) in human gene promoters, we found aggressiveness-related candidate SNP markers, including rs1143627 (associated with higher aggressiveness in patients undergoing cytokine immunotherapy), rs544850971 (higher aggressiveness in old women taking lipid-lowering medication), and rs10895068 (childhood aggressiveness-related obesity in adolescence with cardiovascular complications in adulthood). After validation of these candidate markers by clinical protocols, these SNPs may become useful for physicians (may help to improve treatment of patients) and for the general population (a lifestyle choice preventing aggressiveness-related complications).
The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms.

It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.
We study nonlinear self-imaging dynamics in graded-index multimode optical fibers.

Side-scattering of light that accompanies the propagation of intense femtosecond pulses

permits us to directly measure the self-imaging period.
РЕШЕНИЕ ЭЛЛИПТИЧЕСКИХ УРАВНЕНИЙ В ПОЛИГОНАЛЬНЫХ ОБЛАСТЯХ МЕТОДОМ КОЛЛОКАЦИИ И НАИМЕНЬШИХ КВАДРАТОВ В.П.Шапеев 1,2 , Л.С.Брындин 1,2 , В.А.Беляев 1 1 Институт теоретической и прикладной механики им.С.А.Христиановича СО РАН, г
A comparative analysis of the detonation products and thermodynamic parameters of four individual explosives is performed, and their effect on experimental electrical conductivity is considered. With a carbon fraction greater than 0.1, the electrical conductivity is determined by the carbon content.
Poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerases (PARPs) is one of the immediate cellular responses to DNA damage. The histone PARylation factor 1 (HPF1) discovered recently to form a joint active site with PARP1 and PARP2 was shown to limit the PARylation activity of PARPs and stimulate their NAD + -hydrolase activity.

Here we demonstrate that HPF1 can stimulate the DNA-dependent and DNA-independent autoPARylation of PARP1 and PARP2 as well as the heteroPARylation of histones in the complex with nucleosome. The stimulatory action is detected in a defined range of HPF1 and NAD + concentrations at which no HPF1-dependent enhancement in the hydrolytic NAD + consumption occurs.

PARP2, comparing with PARP1, is more efficiently stimulated by HPF1 in the autoPARylation reaction and is more active in the heteroPARylation of histones than in the automodification, suggesting a specific role of PARP2 in the ADP-ribosylation-dependent modulation of chromatin structure. Possible role of the dual function of HPF1 in the maintaining PARP activity is discussed.
Участие Контрольно-счетной палаты Новосибирской области в осуществлении регионального государственного финансового контроля в сфере государственных
Interindividual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive behavior toward humans for &gt;64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals.
The evolution of the artificial wave packet in swept-wing supersonic boundary layer was experimentally studied at M = 2. The localized disturbances were generated by a pulse glow discharge. Measurements were provided by a hot-wire anemometer. The spatial structure of the wave packet was studied. It was found that the wave packet has an asymmetric shape. In addition, the velocity of the propagation downstream of the wave packet was estimated.
This article examines the results of market transformation of the agrarian sector in Russia 1990s-2000s, as well as social risks of human development. The author defines social risks as possible negative consequences of social policies that represent a threat to human development.

Among them author refers to the lack of resources required for the reproduction of human capital; low public spending on health, education and recreational services not compensated for the lack of individual investments in human capital development; excessive social stratification of society, not conducive to economic growth and social development; low share of the middle class as a support and the driving force of innovation development and social progress; lack of an economic base for the expansion of the middle class.

By summarizing, the author concludes that the lack of resources for human development makes illusory hopes for breakthrough innovation in the development of the agro-food complex in rural areas.
The development of bread wheat introgressions with alien genetic material from cultural and wild Triticeae species is an effective method for expanding the wheat gene pool necessary for breeding. To date, numerous collections of introgressions as substitutions and chromosome modifications have been obtained; however, the creation and study of wheat with new valuable traits still remain an important line of research. Rye Secale cereale L., whose chromosomes carry genes that control valuable economic and biological characteristics and properties, is widely used to produce new wheat forms.

In this study, a wheat-rye translocation obtained by backcrossing the wheat-rye disomic-substitution line 2R(2D)1 with the variety Novosibirskaya 67 was characterized. The chromosomal composition of karyotypes was studied using fluorescent in situ hybridization and C-banding. Two centric translocations, derived from two long arms of chromosomes 2D and 2R, T2DL.2RL, were identified, the remaining 40 wheat chromosomes did not undergo modifications. Meiosis in the lines was stable. Chromosomes T2DL.2RL formed bivalents in all meiocytes, which confirmed their homology.

The morphological characteristics of the spike in the T2DL.2RL line and Novosibirskaya 67 did not differ. A comparative analysis of productivity between the T2DL.2RL translocation line and the parental forms, Novosibirskaya 67 and the 2R(2D)1 line, was carried out. The T2DL.2RL line is inferior to Novosibirskaya 67 in all characters with different confidence levels. The productivity characters of the 2R(2D)1 line exceeded or did not differ from those of T2DL.2RL, however, the mass of 1000 grains was significantly lower. The results showed the effect of the T2DL.2RL translocation on the trait 'plant height'. This character was significantly lower than that of Novosibirskaya 67 in two vegetation periods. Consequently, the T2DL.2RL translocation reduces plant height and productivity.
In dividing cells, expression of mutations is DNA strand symmetric. Of all mutations originating de novo in nondividing cells, only those in the transcribed (noncoding) strand are immediately expressed in mRNA and protein. In contrast, any new mutation in the nontranscribed (coding) strand remains unexpressed until the cells enter S phase and begin proliferation. This previously unrecognized difference enables us to examine the cell cycle-dependent origin of multiple tumorigenic mutations in stem cells.

The human p53 gene, which acts as a gatekeeper in the control of G1 to S phase transition, was chosen for the analysis. Of all multiple mutations contained in p53 databases, we have tested in detail CpG transitions. Three features of CpG sites dictate this choice: C --> T transitions at methylated mCpG are the direct product of mC deamination and are replication-independent; it is easy to identify the strand bearing a primary mC --> T event because C --> T on the transcribed strand appears as G --> A on the nontranscribed strand; and CpG transitions are the most frequent (as both singular and multiple occurrences) tumor-related p53 mutations. The origin of double nonsilent CpG transitions in nondividing cells predicts a significant excess of the heterostrand (C --> T, G --> A) doublets over the homostrand (C --> T, C --> T and G --> A, G --> A) doublets.

For p53, we found such an excess. Based on this result, along with the results of three other tests reported here, we conclude that the majority of multiple p53 mutations from human tumors occurred in quiescent stem cells.
The article presents the results of the practical implementation of the methodology for assessing the innovative potential of small and medium-sized businesses of the Republic of Kazakhstan.To identify the level of development of innovative activity of SMEs in Kazakhstan the methods of correlation and regression analysis were implemented.The analysis conducted on the basis of available statistical materials disclosures the impact of different factors on the innovative potential of small and medium-sized businesses.According to the author's approach to the evaluation of innovative potential, there are three groups of factors affecting the innovative potentialfactors of general economic development, factors of development of small and medium-sized businesses and factors of development of research activities.The article also analyzes the main indicators of innovation activity of the considered enterprises and institutional features of their development.The results of the research allowed to identify both the advantages and disadvantages of innovative activity of national SMEs.
Due to their high optical damage threshold, borate crystals can be used for the efficient nonlinear down-conversion of terawatt laser radiation into the terahertz (THz) frequency range of the electromagnetic spectrum.

In this work, we carried out a thorough study of the terahertz optical properties of the lithium tetraborate crystal (Li2B4O7; LB4) at 295 and 77 K. Approximating the terahertz refractive index in the form of Sellmeier’s equations, we assessed the possibility of converting the radiation of widespread high-power laser sources with wavelengths of 1064 and 800 nm, as well as their second and third harmonics, into the THz range.

It was found that four out of eight types of three-wave mixing processes are possible. The conditions for collinear phase matching were fulfilled only for the o − e → o type of interaction, while cooling the crystal to 77 K did not practically affect the phase-matching curves. However, a noticeable increase of birefringence in the THz range with cooling (from 0.12 to 0.16) led to an increase in the coherence length for o − o → e and e − e → e types of interaction, which are potentially attractive for the down-conversion of ultrashort laser pulses.
The present paper reports on the measurements of flow structure and heat transfer in swirling jets, impinging normally on a flat heated wall.

Velocity field is measured by using the stereoscopic particle image velocimetry technique, whereas the wall temperature is monitored by IR imaging. Two cases of distances between the jet nozzle and impingement surface are considered, namely, one and two nozzle diameters. The Reynolds number is fixed as Re = 5000. Flows of non-swirling, weakly and strongly swirling jets are investigated.

Only for the latter case in free jet flow configuration, the swirl intensity exceeds a critical value for breakdown of the swirling jet's vortex core, corresponding to the formation of a central recirculation zone. For the confined jet conditions, the superimposed swirl in both cases results in presence of an extended recirculation zone between the nozzle and impingement wall, which is found to reduce heat transfer around the stagnation point for the separation distance of two nozzle diameters. However, for the separation distance of one nozzle diameter, the high-swirl jet is found to provide most effective overall cooling of the wall.
Актуальность исследованиясостоит в необходимости расширения минеральной сырьевой базы России. Восточное Забайкалье является одним из старейших золотодобывающих регионов страны. Тем не менее даже в таком хорошо изученном регионе остро стоит вопрос о поисках и обнаружении новых рудных месторождений. Для успешного выполнения такой задачи необходимы данные детального изучения уже известных рудных месторождений, которые могут быть использованы для разработки научно обоснованных критериев поиска рудных месторождений и прогноза оруденения. К таким данным относится определение источников рудоносных магматических расплавов, возраста и условий формирования золотого оруденения Александровского месторождения.

Методы. Для определения элементного состав пород использовался рентгенфлуоресцентный метод и стандартный химический анализ, концентрации редкоземельных элементов измерялисьсорбционно-атомно-эмиссионным анализом с индуктивно-связанной плазмой (ГИН СО РАН, г. Улан-Удэ). Изучение изотопного состава серы сульфидов, содержаний Au и Ag, изотопного возраста (40Ar/39Ar) проведено в Центре коллективного пользования многоэлементных и изотопных исследований СО РАН (г. Новосибирск). Флюидные включения в кварце рудных жил изучены традиционными методами термобарогеохимии и методом КР-спектроскопии.

Результаты. Определен возраст (40Ar/39Ar) синрудного серицита (162 ±2,3 млн лет), соответствующий возрасту интрузий амуджикано-шахтаминского комплекса. Установлено, что вариации изотопного состава кислорода рудоносного кварца, изотопов серы сульфидов соответствуют флюиду магматической природы. Анализ распределения редких и редкоземельных элементов указывает на то, что источниками оруденения были разноглубинные, в разной степени дифференцированные магматические очаги, функционировавшие как в верхней, так и в нижней континентальной коре. По данным исследования флюидных включений в кварце рудных жил, кристаллизация минеральных парагенезисов руд месторождения происходила в интервале температур от 150 до 402°С. Продуктивная минеральная ассоциация формировалась при температуре 402–360°С. Установлено участие в процессе рудообразования рудообразующих флюидов, различающихся по солевому составу, что указывает на разные условия генерации и природу рудообразующих флюидов. Отличительной особенностью месторождения является образование руд за счет разноглубинных, в разной степени дифференцированных рудоносных магматических источников.
EDITORIAL article Front. Genet., 02 February 2022 | https://doi.org/10.3389/fgene.2022.831320
Isolated human ribosomal protein uS3 has extra-ribosomal functions including those related to base excision DNA repair, e.g. AP lyase activity that nicks double-stranded (ds) DNA 3΄ to the abasic (AP) site. However, the ability of uS3 residing within ribosome to recognize and cleave damaged DNA has never been addressed. Here, we compare interactions of single-stranded (ss) DNA and dsDNA bearing AP site with human ribosome-bound uS3 and with the isolated protein, whose interactions with ssDNA were not yet studied. The AP lyase activity of free uS3 was much higher with ssDNA than with dsDNA, whereas ribosome-bound uS3 was completely deprived of this activity. Nevertheless, an exposed peptide of ribosome-bound uS3 located far away from the putative catalytic center previously suggested for isolated uS3 cross-linked to full-length uncleaved ssDNA, but not to dsDNA. In contrast, free uS3 cross-linked mainly to the 5΄-part of the damaged DNA strand after its cleavage at the AP site. ChIP-seq analysis showed preferential uS3 binding to nucleolus-associated chromatin domains. We conclude that free and ribosome-bound uS3 proteins interact with AP sites differently, exhibiting their non-translational functions in DNA repair in and around the nucleolus and in regulation of DNA damage response in looped DNA structures, respectively.
We report searches for ${B}^{0}\ensuremath{\rightarrow}\text{invisible}$ and ${B}^{0}\ensuremath{\rightarrow}\text{invisible}+\ensuremath{\gamma}$ decays, where the energy of the photon is required to be larger than 0.5 GeV. These results are obtained from a $711\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ data sample that contains $772\ifmmode\times\else\texttimes\fi{}{10}^{6}B\overline{B}$ pairs and was collected near the $\mathrm{\ensuremath{\Upsilon}}(4S)$ resonance with the Belle detector at the KEKB ${e}^{+}{e}^{\ensuremath{-}}$ collider. We observe no significant signal for either decay and set upper limits on their branching fractions at 90% confidence level of $\mathcal{B}({B}^{0}\ensuremath{\rightarrow}\text{invisible})<7.8\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ and $\mathcal{B}({B}^{0}\ensuremath{\rightarrow}\text{invisible}+\ensuremath{\gamma})<1.6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$.
Long-term data on flowering phenology of 9 Campanula L. species were processed using computer modeling.

Modified model is proposed to describe flowering of monocarpic shoots with multi-flowered inflorescences taking into account structural inflorescence features and morphogenesis of floral zone. The flowering patterns are determined by degree of inflorescence branching and sequence of flowers opening in them.

It is shown that flowering curve for simple inflorescences is unimodal: it has single peak associated with opening of terminal flower and flowers on the 1st order axes. For compound inflorescences two maxima are noted (the second of them is due to opening of flowers on the 2nd order axes), or curve has wavy character. Regression curves describing sequence of flowers opening on the 1 st order axes are different. They are C-shaped if flowering begins in lower third of the inflorescence and then spreads divergently. More often terminal flower opens first, and is accompanied by several flowers in lower third of inflorescence, while next flowers open in divergent way. In this case the regression curves are S-shaped. The proposed model reproduces picture of individual flowering with natural variability, and can be used to describe flowering of various taxa of herbaceous plants with multi-flowered inflorescences.
We consider multiprocessor task scheduling problems with dedicated processors. We determine the tight optima localization intervals for different subproblems of the basic problem.

Based on the ideas of a computer‐aided technique developed by Sevastianov and Tchernykh for shop scheduling problems, we elaborate a similar method for the multiprocessor task scheduling problem. Our method allows us to find an upper bound for the length of the optimal schedule in terms of natural lower bound.

As a byproduct of our results, a family of linear‐time approximation algorithms with a constant ratio performance guarantee is designed for the NP‐hard subproblems of the basic problem, and new polynomially solvable classes of problems are found.
AgGd(MoO4)2:Ho3+/Yb3+ double molybdates with five concentrations of Ho3+ and Yb3+ were synthesized by the microwave employed sol–gel based process (MES), and the crystal structure variation, concentration effects, and spectroscopic characteristics were investigated. The crystal structures of AgGd1−x−yHoxYby(MoO4)2 (x = 0, 0.05; y = 0, 0.35, 0.4, 0.45, 0.5)at room temperature were determined in space group I41/a by Rietveld analysis. Pure AgGd(MoO4)2 has a scheelite-type structure with mixed occupations of (Ag,Gd) sites and cell parameters a = 5.24782 (11) and c = 11.5107 (3) Å, V = 317.002 (17) Å3, Z = 4. In doped samples, the sites are occupied by a mixture of (Ag,Gd,Ho,Yb) ions, which provides a linear cell volume decrease with the doping level increase. Under the excitation at 980 nm, AGM:0.05Ho,yYb phosphors exhibited a yellowish green emission composed of red and green emission bands according to the strong transitions 5F5 → 5I8 and 5S2/5F4 → 5I8 of Ho3+ ions. The evaluated photoluminescence and Raman spectroscopic results were discussed in detail. The upconversion intensity behavior dependent on the Yb/Ho ratio is explained in terms of the optimal number of Yb3+ ions at the characteristic energy transfer distance around the Ho3+ ion.