Hengzongshu/ArticleAgent huggingface dataset:
There is currently no approved antiviral therapy for treatment of Marburg virus disease (MVD). Although filovirus infection outbreaks are quite rare, the high mortality rates in such outbreaks make the development of anti-filoviral drugs an important goal of medical chemistry and virology.

Here, we performed screening of a large library of natural derivatives for their virus entry inhibition activity using pseudotype systems. The bornyl ester derivatives containing saturated N-heterocycles exhibited the highest antiviral activity. It is supposed that compounds with specific inhibitory activity toward MarV-GP-dependent virus entry will inhibit the rVSIV-ΔG-MarV-GP pseudotype much more efficiently than the control rVSIV-ΔG-G pseudotype. At the same time, the compounds similarly inhibiting both pseudotypes will likely affect rVSIV capsid replication or the cellular mechanisms common to the entry of both viruses.

Borneol itself is not active against both pseudotypes and is nontoxic, whereas its derivatives have varying toxicity and antiviral activity. Among low-toxic borneol derivatives, six compounds turned out to be relatively specific inhibitors of MarV-GP-mediated infection (SC > 10). Of them, compound 6 containing a methylpiperidine moiety exhibited the highest virus-specific activity. Notably, the virus-specific activity of this compound is twice as high as that of the reference.
Reaction of heterometallic cubane-type cluster complexes—[Mo3{Pd(dba)}S4Cl3(dbbpy)3]PF6, [Mo3{Pd(tu)}S4Cl3(dbbpy)3]Cl and [Mo3{Pd(dba)}S4(acac)3(py)3]PF6, where dba—dibenzylideneacetone, dbbpy—4,4′-di-tert-butyl-2,2′-bipyridine, tu—thiourea, acac—acetylacetonate, py—pyridine, with white phosphorus (P4) in the presence of water

The crucial role of the Pd atom in the cluster core {Mo3PdS4} has been established in the hydrolytic activation of P4 molecule. The main intermediate of the process, the cluster complex [Mo3{PdP(OH)3}S4Cl3(dbbpy)3]+ with coordinated P(OH)3 molecule and phosphine PH3, have been detected by 31P NMR spectroscopy in the reaction mixture.

leads to the formation of phosphorous acid H3PO3 as the major product.
Aim. To study factors of endothelial dysfunction in order to find their associations with coagulation factors, inflammatory markers and unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis. Material and methods . The study included men with coronary atherosclerosis without acute coronary syndrome. We assessed blood concentrations of endothelial dysfunction factors (endothelin 1, monocyte chemoattractant protein-1 (MCP-1), adhesion molecules sVCAM-1, asymmetric dimethylarginine, homocysteine, plasminogen activator inhibitor-1) blood coagulation (factor II, factor VII, factor XII, antithrombin III), biomarkers of inflammation (tumor necrosis factor alpha, interleukins (IL-1-beta, IL-6, IL-8), C-reactive protein). Results. The presence of unstable atherosclerotic plaques was associated with an increased blood level of MCP-1 (1,9 times higher; p<0,05) and a reduced concentration of sVCAM-1 (1,4 times lower; p<0,05) compared with men who withiut unstable plaques in the coronary arteries. The largest number of correlations was found between the level of MCP-1 in blood, concentrations of factor VII, antithrombin III, IL-8, C-reactive protein, IL-1 beta and the presence of unstable atherosclerotic plaques in men. Conclusion. The results showed that the relative risk of unstable atherosclerotic plaques in the coronary arteries is associated with an increased level of MCP-1 in the blood.
The wavelet analysis of the integral images can be used in extraction of the depth of the photographed/synthesized 3D objects. The result of the analysis, however, depends on the colour/texture of the object and thus can be ambiguous.

In this paper, we propose to normalize the image before processing in order to avoid such an ambiguity, and to extract the depth without regard to the colour/texture.

The proposed technique is verified in multiple integral/plenoptic images and can be applied to multiview and light-field displays as well.
Fragments of rough endoplasmic reticulum containing polysomes bound to the membranes only at the 5 end were visualized in electron microscopic spreads from Chironomus thummi salivary gland cells. The length of the nascent protein molecules in the polysomes increased from the 5 to the 3 (free) polysome end. The data obtained disagree with the generally accepted model according to which synthesis of secretory proteins is concomitant with the protein transport across the endoplasmic membrane.
The purpose of the study is to determine the main semantic variations of the mythological archetype of voice in the oral tradition, subsequently embedded in the socio-cultural and linguistic mentality.

The scientific novelty of the study lies in conducting a comprehensive analysis of the voice archetype that has not been undertaken before and providing a description of its semiotic capabilities at an early stage of the formation of a mythological paradigm that responds to the topical issue of language and thought.

As a result of the study, the following semantic variations have been identified in the voice archetype: the transfer of voice acoustic properties on natural phenomena (god’s word is thunder, his weapon is lightning, his breath is the wind) and the reflection of the heavenly elements in the human speech, i.e. the power of incantations; personification of voice (speech) as of gods of eloquence and prayers; the transfer of voice semantics into the field of divine knowledge with the acquisition of constitutive power; voice abstraction (voice as an opinion, voice of conscience, rumour).
The process e⁺e⁻→ηηγ is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb⁻¹ collected by the SND detector at the VEPP-2000 e⁺e⁻ collider.

The e⁺e⁻→ηηγ cross section is measured for the first time. It is shown that the dominant mechanism of this reaction is the transition through the φη intermediate state. The search for radiative processes contributing to the e⁺e⁻→ηηγ cross section is performed.

Our result on the e⁺e⁻→ηηγ cross section is consistent with the e⁺e⁻→φη measurement in the φ→K⁺K⁻ mode. No significant signal is observed for radiative processes contributing to the e⁺e⁻→ηηγ cross section.
Let Λ be the group generated by reflections in faces of a Coxeter tetrahedron in the hyperbolic space H 3 .

A tetrahedral manifold is a hyperbolic manifold M = H 3 /Γ uniformized by a torsion free subgroup Γ of the group Λ. By a mirror symmetry we mean an orientation reversing isometry of the manifold acting by reflection.

The aim of the paper to investigate mirror symmetries of the tetrahedral manifolds.
Wir untersuchen eine neuartige Gruppe von Polarisationsmitteln – gemischtvalente Verbindungen – mittels theoretischer und experimenteller Methoden und demonstrieren ihre Leistungsfähigkeit in NMR‐Experimenten mit Hochfeld‐DNP (DNP=Dynamic Nuclear Polarization, dynamische Kernpolarisation) im festen Zustand. Diese gemischtvalenten Verbindungen stellen eine Gruppe von Molekülen dar, bei denen die molekulare Mobilität auch in Festkörpern erhalten bleibt. Folglich können solche Polarisationsmittel unter günstigen Bedingungen für die dynamische Kernpolarisationsbildung bei ultrahohen Magnetfeldern verwendet werden, um Overhauser‐DNP‐Experimente im Festkörper durchzuführen.
Hundreds of genome-wide association studies (GWAS) of human traits are performed each year. The results of GWAS are often published in the form of summary statistics. Information from summary statistics can be used for multiple purposes – from fundamental research in biology and genetics to the search for potential biomarkers and therapeutic targets. While the amount of GWAS summary statistics collected by the scientific community is rapidly increasing, the use of this data is limited by the lack of generally accepted standards. In particular, the researchers who would like to use GWAS summary statistics in their studies have to become aware that the data are scattered across multiple websites, are presented in a variety of formats, and, often, were not quality controlled. Moreover, each available summary statistics analysis tools will ask for data to be presented in their own internal format. To address these issues, we developed GWAS-MAP, a high-throughput platform for aggregating, storing, analyzing, visualizing and providing access to a database of big data that result from region- and genome-wide association studies. The database currently contains information on more than 70 billion associations between genetic variants and human diseases, quantitative traits, and “omics” traits. The GWAS-MAP platform and database can be used for studying the etiology of human diseases, building predictive risk models and finding potential biomarkers and therapeutic interventions. In order to demonstrate a typical application of the platform as an approach for extracting new biological knowledge and establishing mechanistic hypotheses, we analyzed varicose veins, a disease affecting on average every third adult in Russia. The results of analysis confirmed known epidemiologic associations for this disease and led us to propose a hypothesis that increased levels of MICB and CD209 proteins in human plasma may increase susceptibility to varicose veins.
Results of experiments and numerical modeling of gas-powder flow for laser cladding are presented. Numerical simulation is based on solving Navier-Stokes equations with Lagrange approach for particle. The main attention is paid to the process of interaction between powder particles and nozzle walls. Simple particle-wall interaction model was suggested and verified with experiments for gas-powder jet formed in the long tubes with different diameters. The model was used for simulation of powder transport in the coaxial nozzle for laser cladding.
20 世纪 70 年代末 80 年代初，对外汉语教学经过几十年的发展，出现了一派改革的新形势。在这场改革中，按语言技能设课成为一种倾向，听力课由此成为一门独立的课型，关于听力教学的研究也逐渐多了起来。

本文从实践出发，对 2018 年春季复旦大学来华留学生中 39 名中级水平学生的听力学习情况进行了调查，分别从学生对听力课的态度、对听力课的认知、对教材的使用体验、对教师的满意度以及练习题设置五个方面做了详细的调查和分析。

为了提高中级汉语听力教学的效果，本文基于此次调查和分析的结果，拟从听力课本身、听力内容、
DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins remaining largely unexplored.

We used solution NMR spectroscopy, restrained and free molecular dynamics to obtain the structures and investigate dominant motions for a set of DNA duplexes containing CpG sites permuted with combinations of 5-methylcytosine (mC), the primary epigenetic base, and 8-oxoguanine (oxoG), an abundant DNA lesion. Guanine oxidation significantly changed the motion in both hemimethylated and fully methylated DNA, increased base pair breathing, induced BI→BII transition in the backbone 3' to the oxoG and reduced the variability of shift and tilt helical parameters. UV melting experiments corroborated the NMR and molecular dynamics results, showing significant destabilization of all methylated contexts by oxoG.

Notably, some dynamic and thermodynamic effects were not additive in the fully methylated oxidized CpG, indicating that the introduced modifications interact with each other. Finally, we show that the presence of oxoG biases the recognition of methylated CpG dinucleotides by ROS1, a plant enzyme involved in epigenetic DNA demethylation, in favor of the oxidized DNA strand. Thus, the conformational and dynamic effects of spurious DNA oxidation in the regulatory CpG dinucleotide can have far-reaching biological consequences.
We report results of systematic measurements of charge transport properties of the 20.5nm wide HgTe-based quantum well in perpendicular magnetic field, performed under hydrostatic pressures up to 15.1 kbar. At ambient pressure transport is well described by the two-band semiclassical model.In contrast, at elevated pressure, we observed non-monotonic pressure dependence of resistivity at CNP. For pressures lower than $\approx9$ kbar, resistivity grows with pressure, in accord with expectations from the band structure calculations and the model incorporating effects of disorder on transport in 2D semimetals with indirect band overlap. For higher pressures, the resistivity saturates and starts decreasing upon further increase of pressure. Above $\approx14$ kbar the resistance and hopping transport character sharply change, which may indicate formation of the excitonic insulator state. The data also reveals strong influence of disorder on transport in 2D electron-hole system with a small band overlap.
We assume that current state of the Universe is described by the Inert Doublet Model, containing two scalar doublets, one of which is responsible for EWSB and masses of particles and the second one having no couplings to fermions and being responsible for dark matter.We consider possible evolutions of the Universe to this state during cooling down of the Universe after inflation.We found that in the past Universe could pass through phase states having no DM candidate.In the evolution via such states in addition to a possible EWSB phase transition (2-nd order) the Universe sustained one 1-st order phase transition or two phase transitions of the 2-nd order.
Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth factor (TGF-β)/bone morphogenetic protein (BMP) signaling and epithelial-mesenchymal transition (EMT) in lung cancer. AMH is a TGF-β/BMP superfamily member, and AMHR2 heterodimerizes with type I receptors (ALK2, ALK3) also used by the type II receptor for BMP (BMPR2). AMH signaling regulates expression of BMPR2, ALK2, and ALK3, supports protein kinase B-nuclear factor κB (AKT-NF-κB) and SMAD survival signaling, and influences BMP-dependent signaling in non-small cell lung cancer (NSCLC). AMH and AMHR2 are selectively expressed in epithelial versus mesenchymal cells, and loss of AMH/AMHR2 induces EMT. Independent induction of EMT reduces expression of AMH and AMHR2. Importantly, EMT associated with depletion of AMH or AMHR2 results in chemoresistance but sensitizes cells to the heat shock protein 90 (HSP90) inhibitor ganetespib. Recognition of this AMH/AMHR2 axis helps to further elucidate TGF-β/BMP resistance-associated signaling and suggests new strategies for therapeutic targeting of EMT.
The method of Fe3O4 magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry. The experimental details of nanoparticle administration to tumor-bearing mice, magnetic resonance imaging scanning as well as subsequent tumor sample collection and their processing for transmission electron microscopy, inductively coupled plasma atomic emission spectroscopy, histological and immunohistochemical analyses are described.

Biodistribution of the nanoparticles in mice and blood serum analysis data for experimental animals are given. The data are useful for an experiment workflow design and for the development of theranostic systems based on magnetic nanoparticles.
Let G be a locally finite group and let F(G) be the Hirsch–Plotkin radical of G. Let S denote the full inverse image of the generalized Fitting subgroup of G/F(G) in G. Assume that there is a number k such that the length of every nested chain of centralizers in G does not exceed k. The Borovik–Khukhro conjecture states, in particular, that under this assumption, the quotient G/S contains an abelian subgroup of finite index bounded in terms of k.

We disprove this statement and prove a weak analogue of it.

We disprove this statement and prove a weak analogue of it.
Currently, microwave is one of the most interesting ways to conduct drying of dielectric materials, in particular coal.

In this paper, two processes were considered - heating and drying. The temperature field of the coal semi-mass in the heating mode is found analytically strictly with the use of integral transformations. The drying process is formulated as a nonlinear Stephen problem with a moving boundary of the liquid-vapor phase transformation. The temperature distribution, speed and drying time in this mode are determined approximately analytically.

Parametric analysis of the influence of the material and boundary conditions on the dynamics of warming up and drying is revealed.
We first prove the following: Let [Formula: see text] and [Formula: see text]. Let [Formula: see text] and [Formula: see text] be closed, oriented, [Formula: see text]-dimensional [Formula: see text]-connected, simple submanifolds of [Formula: see text]. Then [Formula: see text] and [Formula: see text] are isotopic if and only if a Seifert matrix associated with a simple Seifert hypersurface for [Formula: see text] is [Formula: see text]-[Formula: see text]-equivalent to that for [Formula: see text]. We also discuss the [Formula: see text] case. This result implies one of our main results: Let [Formula: see text]. A 1-link [Formula: see text] is pass-equivalent to a 1-link [Formula: see text] if and only if [Formula: see text] is [Formula: see text]-pass-equivalent to [Formula: see text]. Here, [Formula: see text] means the knot product of [Formula: see text] and [Formula: see text], and [Formula: see text] means [Formula: see text]. See the body of the paper for the definition of knot products. It also implies the other main results: We strengthen the authors’ old result that two-fold cyclic suspension commutes with the performance of the twist move for spherical [Formula: see text]-knots. See the body for the precise statement. Furthermore, it implies the following: Let [Formula: see text] and [Formula: see text]. Let [Formula: see text] be a closed oriented [Formula: see text]-submanifold of [Formula: see text]. Then [Formula: see text] is a Brieskorn submanifold if and only if [Formula: see text] is [Formula: see text]-connected, simple and has a [Formula: see text]-Seifert matrix associated with a simple Seifert hypersurface that is [Formula: see text]-[Formula: see text]-equivalent to a [Formula: see text]-type (see the body of the paper for a definition). We also discuss the [Formula: see text] case.
2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-5-(4-iodophenyl)-4,4-dimethyl-4H-imidazole 3-oxide reacts with phenylboronic acid and its substituted derivatives in a cross-coupling reaction of the Suzuki-Miyaura type to form 5-biphenyl derivatives of 4H-imidazole-N-oxide. Interaction of the same compound with B2(pin)2 in the presence of PdCl2(PPh3)2 proceeds through the formation of intermediate 1,3,2-dioxoborolane and leads to the product of homocoupling: biphenyl-bis(imidazole). Oxidation of the resultant imidazoles with lead dioxide quantitatively yields stable conjugated phenoxyl-nitroxyl mono- and diradicals, which are of interest as electroactive paramagnetic materials. The crystal structure of the monoradical, 2,6-di-tert-butyl-4-[1-oxido-4-(biphenyl-4-yl)-5,5-dimethyl-1H-imidazole-2(5H)-ylidene]cyclohex-2,5-dienone, its magnetic susceptibility, EPR spectra of the obtained hybrid radicals in solution, and cyclic voltammetry characteristics of 4H-imidazoles were studied.
Elevated glucocorticoid level in the early postnatal period is associated with glucocorticoid therapy prescribed at preterm delivery most often has severe long-lasting neurodevelopmental and behavioural effects. Detailed molecular mechanisms of such programming action of antenatal glucocorticoids on behaviour are still poorly understood.

To address this question we studied neurotrophins: Bdnf , Nt-3 , Ngf and their receptors: p75ngfr , Sorcs3 expression changes after subcutaneous dexamethasone (DEX) 0.2 mg/kg injection to P2 rat pups. Neurotrophins expression level was studied in the hippocampus (HPC). p75ngfr and Sorcs3 expression was studied in the brainstem—region where monoamine neurons are located. Immunohistochemically P75NTR protein level changes after DEX were investigated in the brainstem Locus Coereleus norepinephrine neurons (NE). Impact of elevated glucocorticoid level in the neonatal period and unpredictable stress (CMUS) at the end of adolescence on depressive-like behaviour was studied.

In the first hours after DEX administration elevation of neurotrophins expression in HPC and decline of receptor’s expression in the NE brainstem neurons were observed. Single neonatal DEX injection leads to decrease in depressive-like behaviour, observed in FST, independently from chronic stress. Neonatal DEX administration decreased Ntf3 and SorCS1 expression in the brainstem. Also Bdnf mRNA level in the brainstem of these animals didn’t decrease after FST. CMUS at the end of adolescence changed p75ngfr and SorCS3 expression in the brainstem in the animals that received single neonatal DEX administration.
The characteristics of MIS structures based on insulating PbSnTe:In films with compositions in the vicinity of a band inversion grown by molecular beam epitaxy (MBE) were studied. It has been shown that a number of their features can be caused by a ferroelectric phase transition with a Curie temperature in the range T ≈ 15–20 K.
Multiplex PCR has multiple applications in molecular biology, including developing new targeted NGS-panels.

We present NGS-PrimerPlex, an efficient and versatile command-line application that designs primers for different refined types of amplicon-based genome target enrichment. It supports nested and anchored multiplex PCR, redistribution among multiplex reactions of primers constructed earlier and extension of existing NGS-panels. The primer design process takes into consideration formation of secondary structures, non-target amplicons between all primers of a pool, primers and high-frequent genome SNPs overlapping. Moreover, users of NGS-PrimerPlex are free from manually defining input genome regions, because it can be done automatically from a list of genes or their parts like exon or codon numbers.

Using the program, NGS-panel for sequencing the LRRK2 gene coding regions was created, and 354 DNA samples were studied successfully with median coverage of 97.4% of target regions by at least 30 reads.
Boron neutron capture therapy (BNCT) is an anticancer modality realized through 10B accumulation in tumor cells, neutron irradiation of the tumor, and decay of boron atoms with the release of alpha-particles and lithium nuclei that damage tumor cell DNA. As high-LET particle release takes place inside tumor cells absorbed dose calculations are difficult, since no essential extracellular energy is emitted. We placed gold nanoparticles inside tumor cells saturated with boron to more accurately measure the absorbed dose. T98G cells accumulated ~50 nm gold nanoparticles (AuNPs, 50 µg gold/mL) and boron-phenylalanine (BPA, 10, 20, 40 µg boron-10/mL), and were irradiated with a neutron flux of 3 × 108 cm−2s−1. Gamma-rays (411 keV) emitted by AuNPs in the cells were measured by a spectrometer and the absorbed dose was calculated using the formula D = (k × N × n)/m, where D was the absorbed dose (GyE), k—depth-related irradiation coefficient, N—number of activated gold atoms, n—boron concentration (ppm), and m—the mass of gold (g). Cell survival curves were fit to the linear-quadratic (LQ) model. We found no influence from the presence of the AuNPs on BNCT efficiency. Our approach will lead to further development of combined boron and high-Z element-containing compounds, and to further adaptation of isotope scanning for BNCT dosimetry.