Hengzongshu/ArticleAgent huggingface dataset:
Foreign investments are the driving force in the development of the Russian oil and gas complex and the economy as a whole. So it was until 2014, today’s situation has changed somewhat: the influx of foreign investment in the energy sector of is complicated not only by imposed sanctions, but also the main obstacle - the instability of world energy prices.

This paper is devoted to a comprehensive analysis of the impact of foreign investment on the development of the oil and gas sector in Russia, which includes both directions: the impact of foreign direct investment inflows on the production and economic indicators of the oil and gas sector of Russia, and the effect of these indicators on foreign investment inflows.

The current price environment, as well as the supply and demand situation are pushing foreign investors to reduce the investment proposal. Today, the fuel and energy complex, and especially OGC, plays a huge role in the socio-economic development of the country and the increase in GDP, which determines the purpose and objectives of this study.
DNA N-glycosylases are key enzymes responsible for initiating the base excision repair of redox damaged bases in DNA.

In our studies a thermodynamic analysis of the interaction of DNA glycosylases ...
The article provides a brief overview of the problems of diagnostics and etiological verification of restrictive cardiomyopathy (RCMP). Multiple causes lead to the restrictive phenotype of intracardiac hemodynamics and diastolic dysfunction of the heart: infiltrative (amyloidosis, sarcoidosis, elastoma, metabolic syndrome, tumor metastasis to the myocardium); endomyocardial (tropical endomyocardial fibrosis, hypereosinophilic syndrome, carcinoid, radiation damage); accumulation diseases (hemochromatosis, Pompe and Gaucher diseases, Fabry disease). RKMP is also characteristic for desminopathy — so-called desmin storage disease.

This is a disease caused by mutations in the desmin gene (DES) that determine the development of cardiomyopathy or myofibrillar myopathy, and in some cases cause a combined phenotype of the disease. Desmin belongs to the group of intermediate filaments that maintain the structural and functional integrity of myofibrils. Mutations in DES lead to disruption of the assembly of filaments and a change in the myofibrillar cell lattice, which contributes to an increased vulnerability of myocytes to mechanical stress.

The article presents a clinical case of familial desminopathy associated with a new missense R118P mutation of DES gene, characterized by dominant cardiac RCMP phenotype and subclinical manifestations of myofibrillar myopathy.
The paper presents numerical simulation of the flow in hydraulic turbine based on the experimental data of the II Francis-99 workshop. The calculation domain includes the wicket gate, runner and draft tube with rotating reference frame for the runner zone. Different turbulence models such as k-ω SST, ζ-f and RSM were considered. The calculations were performed by means of in-house CFD code SigmaFlow. The numerical simulation for part load, high load and best efficiency operation points were performed.
Experimental results of observation of ethanol and propylene glycol microjets flowing into a highly rarefied medium (vacuum) through a nozzle are presented. The study of the outflow process was carried out both for horizontal and vertical outflow of liquid from the source in the direction of gravity. The condition was met for maintaining the residual gas background pressure in the discharge chamber much lower than the saturated vapor pressure of the working fluid at the selected discharge temperature. It is established that the flow from a thin capillary or small-diameter nozzle into a vacuum or highly rarefied gas medium differs significantly from the well-studied flow modes into a dense gas medium. It is shown that in all studied regimes the fluid flow is statistically unstable, with a large number of sudden changes in direction, structure, and observed density. The paper describes the main features of such a flow and the conditions for the onset of instability.
DNA repair capacity in cells of naked mole rat (Hgl), a species known for its longevity and resistance to cancer, is still poorly characterized.

Here, using the whole-cell extracts (WCEs) of Hgl, mouse and human cells, we studied the interrelation between DNA synthesis on the substrates of base excision repair and the activity of poly(ADP-ribose) polymerases (PARPs) responsible for the transfer of the ADP-ribose moieties onto different targets. The level of PAR synthesis was more than ten-fold higher in human WCE as compared to rodent WCEs, while the efficiency of DNA synthesis was comparable. Under conditions of PAR synthesis, the efficiency of DNA synthesis was only slightly enhanced in all extracts and in mouse WCEs unusual products of the primer elongation were detected. The results obtained with WCEs, recombinant proteins and recently found ability of PARPs to attach the ADP-ribose moieties to DNA allowed us to attribute these products to primer mono(ADPribosyl)ation (MARylation) at the 5ʹ-terminal phosphate by PARP3 during the DNA synthesis.

PARP1/PARP2 can then transfer the ADP-ribose moieties onto initial ADP-ribose. Our results suggest that MARylation/PARylation of DNA in the extracts depends on the ratios between PARPs and can be controlled by DNA-binding proteins.
according to which synthesis of secretory proteins is concomitant with the protein transport across the endoplasmic membrane

Fragments of rough endoplasmic reticulum containing polysomes bound to the membranes only at the 5 end were visualized in electron microscopic spreads from Chironomus thummi salivary gland cells. The length of the nascent protein molecules in the polysomes increased from the 5 to the 3 (free) polysome end

The data obtained disagree with the generally accepted model
Results of the first stage of the researches conducted in 2012-2013 are presented in article. Researches are connected with studying of transformational processes intra corporate of management practices in the Russian companies and their subsequent institutionalization. Preliminary results showed that in the companies there is a standard set of organizational routines which part are information, and administrative routines, routines of the power of the founder, genetic, institutional and development routines. During research statistically significant connection between types of organizational structures, the sizes of the organization, information processing and administrative practices is established. It is revealed as change of approaches to management of the organization can affect a corruption component.
Specific features of the LIGA-technology methods elaborated at the Siberian Synchrotron and Terahertz Radiation Centre (SSTRC, BINP SB RAS) and fabrication of terahertz filters and optical elements based on high-aspect self-bearing microstructures of the pseudo-metallic type are described.

The essence of the method consists in deep X-ray lithographic patterning of an organic glass (PMMA) substrate followed by covering its entire surface with a thin layer of metal (silver).

The structures produced are using in the experiments at the Novosibirsk free electron laser.
АннотацияИсследованы методы формирования синтезированного изображения с увеличенной глубиной резкости из последовательности кадров, оперативно полученных при фокусировке на различную дальность с применением жидкостной оптики.Разработан алгоритм, основанный на построении картосхемы дальностей путем анализа пирамиды контраста и взвешен-
Leukocytes are the main cells of immune system, but also contribute to other systems and participate in pathogenesis of different diseases. In particular, leukocytes are involved in the progression of diabetic retinopathy due to their hyperactivation in diabetes. However, a connection between diabetes and the dysfunction of leukocytes is poorly understood. For a more complete picture, studies of the leukocytes activation under the influence of various substances are necessary. Arachidonic acid (AA) and its metabolites are the strongest activating factors of leukocytes. However, the studies involving AA are complicated because it is water-insoluble. Here we describe the method to study activation using photolabile analogs of AA.
Telomeres are generally considered heterochromatic. On the basis of DNA composition, the telomeric region of Drosophila melanogaster contains two distinct subdomains: a subtelomeric region of repetitive DNA, termed TAS, and a terminal array of retrotransposons, which perform the elongation function instead of telomerase.

We have identified several P-element insertions into this retrotransposon array and compared expression levels of transgenes with similar integrations into TAS and euchromatic regions.

In contrast to insertions in TAS, which are silenced, reporter genes in the terminal HeT-A, TAHRE, or TART retroelements did not exhibit repressed expression in comparison with the same transgene construct in euchromatin. These data, in combination with cytological studies, provide evidence that the subtelomeric TAS region exhibits features resembling heterochromatin, while the terminal retrotransposon array exhibits euchromatic characteristics.
High-flux neutron sources are relevant to testing materials for thermonuclear facilities and hadron colliders, treating malignant tumors with boron neutron capture therapy, and other applications.An accelerator-based neutron source was proposed and implemented at the Budker Institute of Nuclear Physics in Novosibirsk, Russia.It comprises an originally designed tandem accelerator, a solid lithium target, and a neutron beam shaping assembly.The neutron source has been found capable of producing high neutron fluxes in different energy ranges, from thermal to fast.It is applicable to a wide range of research tasks, including the characterization of neutron detectors, intended for fusion studies, in-depth investigation of the promising 11 B(p, ) neutronless fusion reaction, etc.
The dual role of the constitutive androstane receptor (CAR) as both a xenosensor and a regulator of endogenous energy metabolism (lipogenesis and gluconeogenesis) has recently gained acceptance. Here, we investigated the effects of 4-[(4R,6R)-4,6-diphenyl-1,3-dioxan-2-yl]-N,N-dimethylaniline (transpDMA), an effective CAR activator, on the gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in rat livers.The effects of transpDMA were investigated in normal and high-fat diet-fed Wistar rats using real-time PCR, Western blotting, chromatin immunoprecipitation assays (ChIP), glucose tolerance test and insulin tolerance test.The expression of the gluconeogenic enzymes PEPCK and G6Pase was repressed by transpDMA treatment under fasting conditions. Long-term CAR activation by transpDMA significantly reduced fasting blood glucose levels and improved glucose homeostasis and insulin sensitivity in high-fat diet-fed rats. The metabolic benefits of CAR activation by transpDMA may have resulted from the inhibition of hepatic gluconeogenic genes. ChIP assays demonstrated that transpDMA prevented the binding of forkhead box O1 (FOXO1) to insulin response sequences in the PEPCK and G6Pase gene promoters in rat livers. Moreover, transpDMA-activated CAR inhibited hepatocyte nuclear factor-4α (HNF4α) transactivation by competing with HNF4α for binding to the specific binding element (DR1-site) in the gluconeogenic gene promoters.Our results provide evidence to support the conclusion that transpDMA inhibits the gluconeogenic genes PEPCK and G6Pase through suppression of HNF4α and FOXO1 transcriptional activity.
The cocrystal of betulin with adipic acid was prepared using a liquid-assisted grinding method. The formation of cocrystal was confirmed by powder X-ray diffraction and IR spectroscopy methods. In order to choose a liquid for preparing cocrystal, solvents of different polarity were compared. It was shown that cocrystal of betulin with adipic acid was formed if solvents were used during mechanical treatment, in which the increased solubility of adipic acid was observed
CRIC is a high-level information system which provides flexible, reliable and complete topology and configuration description for a large scale distributed heterogeneous computing infrastructure. CRIC aims to facilitate distributed computing operations for the LHC experiments and consolidate WLCG topology information. It aggregates information coming from various low-level information sources and complements topology description with experimentspecific data structures and settings required by the LHC VOs in order to exploit computing resources.

Being an experiment-oriented but still experiment-independent information middleware, CRIC offers a generic solution, in the form of a suitable framework with appropriate interfaces implemented, which can be successfully applied on the global WLCG level or at the level of a particular LHC experiment. For example there are CRIC instances for CMS[11] and ATLAS[10]. CRIC can even be used for a special task. For example, a dedicated CRIC instance has been built to support transfer tests performed by DOMA Third Party Copy working group.

Moreover, extensibility and flexibility of the system allow CRIC to follow technology evolution and easily implement concepts required to describe new types of computing and storage resources. The contribution describes the overall CRIC architecture, the plug-in based implementation of the CRIC components as well as recent developments and future plans.
The review systematizes modern data on the biochemical markers that can clarify the nature and the course of chronic bronchitis. The article describes markers associated with bronchopulmonary pathology, such as tumor necrosis factor alpha (TNFα), interleukin 1 (IL-1), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tissue factor, type 1 plasminogen activator inhibitor (PAI-1), and monocyte chemoattractant protein-1 (MCP-1). For each biomolecule, its properties, functions, direct role in body processes, and associations with bronchopulmonary pathology are described. The use of these markers for early diagnosis of bronchopulmonary pathology and monitoring of the treatment effectiveness is promising and requires further in-depth study.
Spin relaxation has been at the core of many studies since the early days of NMR, and the undelying theory worked out by its founding fathers. However, this theory has been recently questioned (Bengs and Levitt (2020)) in the light of Linblad theory of quantum Markovian master equations.

In this article, we review the conventional approach of quantum mechanical theory of NMR relaxation and show that under the usual assumptions, it is equivalent to the Linblad formulation.

We also comment on the debate over semi-classical versus quantum versions of spectral density functions involved in relaxation.
Wrong labels appear as a result of inaccuracy made by a radiologist in the process of manual annotation of computed tomography images.

This paper presents an automatic algorithm for the segmentation of areas affected by an acute stroke on the non-contrast computed tomography brain images. The proposed algorithm is designed for learning in a weakly supervised scenario when some images are labeled accurately, and some images are labeled inaccurately. We propose methods for solving the segmentation problem in the case of inaccurately labeled training data. We use the U-Net neural network architecture with several modifications.

Experiments on real computed tomography scans show that the proposed methods increase the segmentation accuracy.
An electric field that builds in the direction against current, known as negative nonlocal resistance, arises naturally in viscous flows and is thus often taken as a telltale of this regime. Here we predict negative resistance for the ballistic regime, wherein the ee collision mean free path is greater than the length scale at which the system is being probed. Therefore, negative resistance alone does not provide strong evidence for the occurrence of the hydrodynamic regime; it must thus be demoted from the rank of a smoking gun to that of a mere forerunner. Furthermore, we find that negative response is log-enhanced in the ballistic regime by the physics related to the seminal Dorfman-Cohen log divergence due to memory effects in the kinetics of dilute gases. The ballistic regime therefore offers a unique setting for exploring these interesting effects due to electron interactions.
Piwi in a complex with Piwi-interacting RNAs (piRNAs) triggers transcriptional silencing of transposable elements (TEs) in Drosophila ovaries, thus ensuring genome stability. To do this, Piwi must scan the nascent transcripts of genes and TEs for complementarity to piRNAs. The mechanism of this scanning is currently unknown.

Here we report the DamID-seq mapping of multiple Piwi-interacting chromosomal domains in somatic cells of Drosophila ovaries. These domains significantly overlap with genomic regions tethered to Nuclear Pore Complexes (NPCs). Accordingly, Piwi was coimmunoprecipitated with the component of NPCs Elys and with the Xmas-2 subunit of RNA transcription and export complex, known to interact with NPCs. However, only a small Piwi fraction has transient access to DNA at nuclear pores.

Importantly, although 36% of the protein-coding genes overlap with Piwi-interacting domains and RNA-immunoprecipitation results demonstrate promiscuous Piwi binding to numerous genic and TE nuclear transcripts, according to available data Piwi does not silence these genes, likely due to the absence of perfect base-pairing between piRNAs and their transcripts.
We analyzed the interrelation between the efficiency of a gene expression and the nucleotide composition of all protein‐coding sequences in 38 unicellular organisms whose complete genomic sequences are known. These organisms comprise 37 prokaryotic (29 eubacteria and eight archaebacteria) and one eukaryotic (yeast) species. We demonstrated that frequency analysis of gene codon composition fails to reflect adequately the gene expression efficiency of all these organisms. We constructed a measure, the elongation efficiency index, that considers simultaneously the information on codon frequencies and the degree of mRNA local self‐complementarity. This measure recognizes the ribosome‐coding genes as highly expressed in all the unicellular organisms studied. According to our analysis, these species fall into five groups differentiated by the process that makes the key contribution to the elongation rate.
We have proposed and tested a method for characterization of the signal sequences and determinations of target protein localization in a plant cell. This method, called the AgI-PrI, implies extraction of protoplasts from plant tissues after agroinfiltration. The suggested approach combines the advantages of two widely used methods for transient gene expression in plants-agroinfiltration and transfection of isolated protoplasts. The AgI-PrI technic can be applied to other plant species.
This work represents the first comprehensive report on quantitative metabolomic composition of tissues of pike-perch (Sander lucioperca) and Siberian roach (Rutilus rutilus lacustris).

The total of 68 most abundant metabolites are identified and quantified in the fish lenses and gills by the combination of LC-MS and NMR.

It is shown that the concentrations of some compounds in the lens are much higher than that in the gills; that indicates the importance of these metabolites for the adaptation to the specific living conditions and maintaining the homeostasis of the fish lens. The lens metabolome undergoes significant seasonal changes due to the variations of dissolved oxygen level and fish feeding activity. The most season-affected metabolites are osmolytes and antioxidants, and the most affected metabolic pathway is the histidine pathway. In late autumn, the major lens osmolytes are N-acetyl-histidine and threonine phosphoethanolamine (Thr-PETA), while in winter the highest concentrations were observed for serine phosphoethanolamine (Ser-PETA) and myo-inositol. The presence of Thr-PETA and Ser-PETA in fish tissues and their role in cell osmotic protection are reported for the first time. The obtained concentrations can be used as baseline levels for studying the influence of environmental factors on fish health.
OXYS rats are the model of precocious senescence. Numerous studies addressed physiology and behavior in rats of this strain during a postnatal period of their life, however, preimplantation development in OXYS rats has not yet been investigated.

This study is addressing preimplantation embryonic development in OXYS rats both in vivo and in vitro. Rats of the WAG strain were used as controls. For studying the in vivo development, the embryos were collected from OXYS and WAG rats on day 5 post coitum, the stages of embryo development were estimated, the percentage of embryos at blastocyst stage and the cell numbers in these blastocysts were counted. In a special experiment, for studying in vitro development, the embryos were collected from both rat strains on day 4 post coitum and were cultured in vitro in P1 medium for 48 hours with or without supplementation with IGF-1 (200 ng/mL). Thereafter the percentage of embryos at blastocyst stage and the cell numbers in these blastocysts were counted in the same manner as for the in vivo experiment.

This study reports that in vivo derived blastocysts of OXYS rats contain fewer cells on day 5 of their development than in vivo derived blastocysts of WAG rats. In vitro culture of the early preimplantation embryos in P1 medium mitigated the difference in the rate of embryo development between these two strains, the addition of IGF-1 into culture medium exerts neither negative nor positive effect on the rate of in vitro embryo development in rats of both strains.
During the research seismogeological models of the Neoproterozoic-Phanerozoic sedimentary complexes of the Siberian Platform (Anabar-Khatanga and Lena-Anabar oil and gas regions) northern part were constructed.

The existing geological and geophysical materials do not allow precisely stratify the Laptev Sea basin sedimentary cover. The thickness of platform deposits in which reaches 14-15 kilometers.

It is concluded that in the Anabar-Khatanga and Lena-Anabar oil-and-gas areas Permian anticlinal traps complexly related to the salt diapirs have the best prospects of petroleum production. The carbonate deposits of Riphean-Carbon are also of interest. From the structural-tectonic and general-scientific positions, this sedimentary basin is located in favorable conditions for the formation of hydrocarbon fields.
The article observes the main provisions of the clinical recommendations for prevention, anesthesia and intensive care for postpartum hemorrhage. The main risk factors, possible complications, principles of clinical and laboratory diagnosis in this pathology are consistently presented. Particular attention is paid to issues of infusion, transfusion therapy and correction of coagulopathic disorders. The problems of estimating the amount of blood loss, diagnosing disorders of the hemostatic system, regulation of hemodynamics in hemorrhagic shock are discussed. The use of recombinant coagulation factors in coagulopathy on the background of massive blood loss has been substantiated.
An experimental study of supersonic boundary layer on a flat plate with coating permeability at two Mach numbers 2 and 2.5 was carried out.

The flow disturbances were measured by a constant-temperature anemometer (CTA), operating in the scanning regime. The procedure for calibrating a constant-temperature anemometer has been performed.

It was shown that the coefficients of sensitivity to pulsations of mass flow rate and stagnation temperature are practically independent of the Mach number of the oncoming flow. In experiments on a flat plate with porosity, the positions of the laminar-turbulent transition were determined. The obtained experimental data can be used in calculations and numerical prediction of a laminar-turbulent transition in a supersonic boundary layer.