Hengzongshu/ArticleAgent huggingface dataset:
The dromedary camel is an economically and socially important species of livestock in many parts of the world, being used for transport and the production of milk and meat. Much like cattle and horses, the camel may be found in industrial farming conditions as well as used in sporting. Camel racing is a multi-million dollar industry, with some specimens being valued at upward of 9.5 million USD. Despite its apparent value to humans, the dromedary camel is a neglected species in genomics. While cattle and other domesticated species have had much attention in terms of genome assembly, the camel has only been assembled to scaffold level, which does not give a clear indication of the order or chromosomal location of sequenced fragments.

In this study, the Reference Assistant Chromosome Assembly (RACA) algorithm was implemented to use read-pair information of camel scaffolds, aligned with the cattle and human genomes in order to organize and orient these scaffolds in a near-chromosome level assembly. This method generated 72 large size fragments (N50 54.36 Mb). These predicted chromosome fragments (PCFs) were then compared with comparative maps of camel and cytogenetic map of alpaca chromosomes, allowing us to further upgrade the assembly.

This dromedary camel assembly will be an invaluable tool to verify future camel assemblies generated with chromatin conformation or/and long read technologies. This study provides the first near-chromosome assembly of the dromedary camel, thus adding this economically important species to a growing pool of knowledge regarding the genome structure of domesticated livestock.
The current status of protection of the natural water and atmospheric resources is assessed as negative, without clear improving tendencies but with a stable pro-cyclical character. Unfortunately, the same cannot be said about the management of production and consumption waste. Even in the stagnation periods, the volume of generated and accumulated waste continues growing. In the year 2018, the first indicator doubled compared to the year 2005. Thus, the urgency of the research is augmented by the unfavourable ecological situation in Russia. The objective of the paper is to develop methodological approaches to the analysis and forecasting of the situation. The objective determined the following targets: to study the current state of the environment regarding the handling of waste, to develop premises to forecast generation and accumulation of waste, to assess the ecological load for the nearest future. Despite the active efforts to reform the waste management system undertaken since 2014, the Russian legislation is imperfect and contradictory in this aspect, not capable of stimulating the processing of waste. The principal contradictions of the ongoing reforms are considered in this paper
We propose schemes of controlled-Z and controlled-not gates with ultracold neutral atoms based on deterministic phase accumulation during double adiabatic passage of the Stark-tuned F\"orster resonance of Rydberg states. The effect of deterministic phase accumulation during double adiabatic passage in a two-level quantum system has been analyzed in detail. Adiabatic rapid passage using nonlinearly chirped pulses with rectangle intensity profile has been discussed. Nonlinear time dependence of the energy detuning from the F\"orster resonance is used to achieve a high fidelity of population transfer between Rydberg states. Fidelity of two-qubit gates has been studied with an example of the $90S+96S\ensuremath{\rightarrow}90P+95P$ Stark-tuned F\"orster resonance in Cs Rydberg atoms.
Winter wheat growing areas in the Northern hemisphere are regularly exposed to heavy frost. Due to the negative impact on yield, the identification of genetic factors controlling frost tolerance (FroT) and development of tools for breeding is of prime importance. Here, we detected QTL associated with FroT by genome wide association studies (GWAS) using a diverse panel of 276 winter wheat genotypes that was phenotyped at five locations in Germany and Russia in three years. The panel was genotyped using the 90K iSelect array and SNPs in FroT candidate genes. In total, 17,566 SNPs were used for GWAS resulting in the identification of 53 markers significantly associated (LOD ≥4) to FroT, corresponding to 23 QTL regions located on 11 chromosomes (1A, 1B, 2A, 2B, 2D, 3A, 3D, 4A, 5A, 5B and 7D). The strongest QTL effect confirmed the importance of chromosome 5A for FroT. In addition, to our best knowledge, seven FroT QTLs were discovered for the first time in this study comprising QTLs on chromosomes 3A, 4A, 1B, and two on chromosomes 2D, 3D, and 7D. Identification of novel FroT candidate genes will help to better understand the FroT mechanism in wheat and to develop more effective combating strategies.
. The work aims to check one of the assumptions under which the kinetic equation for water waves was derived in order to understand whether it can be applied to the situations described by the Phillips spectrum. We evaluate a spectral line width of the spectrum from the simulations in the framework of primordial dynamical equations at different levels of nonlinearity in the system, corresponding to the weakly turbulent Kolmogorov–Zakharov spectra ω−4, Phillips spectra ω−5, and intermediate cases. The original motivation of the work was to check one of the assumptions under which the kinetic equation for water waves was derived in order to understand whether it can be applied to the Phillips spectrum. It is shown that, even in the case of relatively high average steepness, when the Phillips spectrum is present in the system, the spectral lines are still very narrow, at least in the region of the direct cascade spectrum. It allows us to state that, even in the case of the Phillips spectrum, one of the assumptions used for the derivation of the Hasselmann kinetic equation is still valid, at least in the case of moderate whitecapping.
Inner Tracker of Novosibirsk Super Charm-Tau Factory Detector has to measure momenta of soft hadrons, which do not reach the drift chamber; complement the drift chamber in measuring the momenta; detect secondary vertices of short-lived particles. Thus, proper choice of the option for the Inner Tracker is of significant interest.

The simulation of charged pions propagation in the perpendicular direction to the beam axis was carried out with DD4HEP program based on GEANT4. Three options were considered: 4-layered Silicon microstrip detector, 4-layered cylindrical Gas Electron Multiplier (GEM) detector and Time Projection Chamber (TPC). The simulated Detector was located in 1.5 T magnetic field directed along beam axis.

The simulation shows that pions with initial momenta less than 50 MeV /c do not pass through the beampipe and cannot be registered. Pions with momenta above 65 MeV /c leave energy depositions in all 4 layers of the Inner Tracker based on Silicon, and their trajectories can be reconstructed. Cylindrical GEM detector provides reconstruction possibility (hits in 4 layers) for pions with momenta more than 60 MeV /c. TPC with thin inner wall provides reconstruction of pions with momenta higher than 55 MeV /c. However, in this case the reconstruction procedure will be much more complicated due to a large number of background particle tracks in the sensitive volume.
There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basis in humans, it is necessary to study animal models. Our previous research on the accelerated-senescence OXYS strain has revealed two quantitative trait loci (QTLs) on rat chromosome 1 that are associated with early cataract and/or retinopathy as well as with behavioral abnormalities.

The present study was designed to analyze the genes of susceptibility to early neurodegenerative processes taking place in the OXYS rat retina and brain and to assess their potential functional clustering. The study was based on the findings from recent publications (including mapping of quantitative trait loci) and on comparative phenotyping of congenic rat strains. The backcrossing of Wistar Albino Glaxo (WAG) and OXYS strains to generate the congenics resulted in two congenic strains with high susceptibility to cataract and retinopathy but with no obvious signs of Alzheimer's disease-like brain pathology that are specific for OXYS rats.

Thus, the genes of susceptibility to brain neurodegeneration were not introgressed into the congenic strains or there is a strong effect of the genetic background on the disease phenotype. Moreover, the progression of retinopathy with age was relatively less severe in the WAG background compared to the OXYS background. A comparative analysis of previously defined QTLs and congenic segments led to identification of candidate genes with a suspected effect on brain neurodegeneration including the genes showing differential expression in the congenic strains. Overall, our findings suggest that the cause of the cataract and the cause of retinopathy phenotypes in OXYS rats may be genetically linked to each other within the introgressed segments in the WAG/OXYS-1.1 and/or WAG/OXYS-1.2 congenic strains.
It has been shown that during evaporation diameter of the drop is almost constant (the contact line is pinned) and starts to decrease only at the final moment of drop life.

This paper presents a study of the evaporation of sessile picoliter liquid drops on a heated solid surface.

It has been shown that the specific evaporation rate of a droplet (droplet weight loss per unit time per unit droplet surface area) is not constant over time: it gradually grows with time up to a maximum, but at the final stage, when the height of the drop becomes on the order of 1 μm, it decreases rapidly.
We carefully rederive the Schiff theorem

prove that the usual expression of the Schiff moment operator is correct and should be applied for calculations of atomic electric dipole moments

The recently discussed corrections to the definition of the Schiff moment are absent
Magnetic resonance imaging of [1-13 C]hyperpolarized carboxylates (most notably, [1-13 C]pyruvate) allows one to visualize abnormal metabolism in tumors and other pathologies. Herein, we investigate the efficiency of 1 H and 13 C hyperpolarization of acetate and pyruvate esters with ethyl, propyl and allyl alcoholic moieties using heterogeneous hydrogenation of corresponding vinyl, allyl and propargyl precursors in isotopically unlabeled and 1-13 C-enriched forms with parahydrogen over Rh/TiO2 catalysts in methanol-d4 and in D2 O. The maximum obtained 1 H polarization was 0.6±0.2 % (for propyl acetate in CD3 OD), while the highest 13 C polarization was 0.10±0.03 % (for ethyl acetate in CD3 OD). Hyperpolarization of acetate esters surpassed that of pyruvates, while esters with a triple carbon-carbon bond in unsaturated alcoholic moiety were less efficient as parahydrogen-induced polarization precursors than esters with a double bond. Among the compounds studied, the maximum 1 H and 13 C NMR signal intensities were observed for propyl acetate. Ethyl acetate yielded slightly less intense NMR signals which were dramatically greater than those of other esters under study.
This paper describes an algorithm for creating hash function, resistant for quantum computer.The given approach is based on the problem of solving a system of polynomial equations in integers, where the number of equations is less than the number of unknown parameters.The developed algorithm is parameterized so the result of the hash function depends on several parameters, therefore, it will take considerably longer to select the solution of the task.The avalanche effect is about 50%, collision is impossible because the task to find a solution of the described system of equations with a degree greater than 3 is algorithmically unsolvable.This hash function was developed for blockchain to ensure its integrity, but it can also be used in any application where a hash function is needed.
Accurate analysis at the single-cell level has become a highly attractive tool for investigating cellular content. An electroosmotic-driven microfluidic chip with arrays of 30-μm-diameter microwells was developed for single-cell electric lysis in the present study. The cellular occupancy in the microwells when the applied voltage was 5 V (82.4%) was slightly higher than that at an applied voltage of 10 V (81.8%). When the applied voltage was increased to 15 V, the cellular occupancy in the microwells dropped to 64.3%. More than 50% of the occupied microwells contain individual cells. The results of electric lysis experiments at the single-cell level indicate that the cells were gradually lysed as the DC voltage of 30 V was applied; the cell was fully lysed after 25 s. Single-cell electric lysis was demonstrated in the proposed microfluidic chip, which is suitable for high-throughput cell lysis.
The recognition of transcription factor binding sites (TFBSs) is the first step on the way to deciphering the DNA regulatory code. There is a large variety of experimental approaches providing information on TFBS location in genomic sequences. Many computational approaches to TFBS recognition based on the experimental data obtained are available, each having its own advantages and shortcomings. This article provides short review of approaches to computational recognition of TFBS in genomic sequences and methods of experimental verification of predicted sites. We also present a case study of the interplay between experimental and theoretical approaches to the successful prediction of Steroidogenic Factor 1 (SF1).
The reaction of [Cp(Bn) Fe(η(5) -P5 )] (1) (Cp(Bn) =η(5) -C5 (CH2 Ph)5 ) with CuI selectively yields a novel spherical supramolecule (CH2 Cl2 )3.4 @[(Cp(Bn) FeP5 )12 {CuI}54 (MeCN)1.46 ] (2) showing a linkage of the scaffold atoms which is beyond the Fullerene topology. Its extended CuI framework reveals an outer diameter of 3.7 nm-a size that has not been reached before using five-fold symmetric building blocks. Furthermore, 2 shows a remarkable solubility in CH2 Cl2 , and NMR spectroscopy reveals that the scaffold of the supramolecule remains intact in solution. In addition, a novel 2D polymer [{Cp(Bn) Fe(η(5) -P5 )}2 {Cu6 (μ-I)2 (μ3 -I)4 }]n (3) with an uncommon structural motif was isolated. Its formation can be avoided by using a large excess of CuI in the reaction with 1.
Aims To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function.

Design Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance. Setting Europe. Participants More than 34 000 adults. Measurements Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed. Findings Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R2 = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: −0.74 SD (95% CI = −1.88, 0.41) for immediate recall, −1.09 SD (95% CI = −2.38, 0.21) for delayed recall, −0.63 SD (95% CI = −1.78, 0.53) for verbal fluency and −0.16 SD (95% CI = −1.29, 0.97) for processing speed.

Conclusions The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.
New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3′ or 5′-end were synthesized and characterized. Low cytotoxicity of the conjugates and their ability to be taken up into cells without transfection agents were demonstrated. Lipid-conjugated siRNAs targeting repulsive guidance molecules a (RGMa) have shown a comparable gene silencing activity in PK-59 cells to unmodified control siRNA when delivered into the cells via Lipofectamine mediated transfection.
The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies.

Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed.

It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.
Thirty-two muskrats (Ondatra zibethicus) were captured for surveillance of avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia, Russia.

A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskrat using chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidase genes of this isolate were classified into the Eurasian avian-like influenza virus clade and closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wild water birds in Italy and Sweden, respectively. Other internal genes were also closely related to LPAIVs isolated from Eurasian wild water birds.

Results suggest that interspecies transmission of LPAIVs from wild water birds to semiaquatic mammals occurs, facilitating the spread and evolution of LPAIVs in wetland areas of Western Siberia.
The goal of the paper is to propose and study a concept of contract-based domination by coalitions for competitive economies. The formal mathematical notion of contract (an elementary exchange of commodities), the contractual allocations of different kinds and their stability properties are introduced and investigated.It is shown that applying this approach one can describe different known classical concepts for a perfect economy — equilibria, core, fuzzy core etc. — in pure game-theoretical terms. For non-perfect economies, in which not every contract is permissible, it may serve as one of the model’s primitives to refine and to solve various theoretical problems.
The paper deals with the analysis of the role and ranking positions of leading corporations. Basic approach of industrial economics is used as the starting point of the analysis. Special coefficients of “sustainability” and “stability” of leadership, indicating companies’ positions, are proposed to describe firms’ market power. Empirical part is based on data provided by national rating agency Expert Ra for a long-term period from 2000 to 2011. Comparison of national and regional markets enabled us to find out that generally the positions of Russian leading corporations are stable and sustainable. Market power of leading companies is rather significant, therefore at the national level, competition could hardly be intensive. More competitive structures are developed at regional level. Regional markets demonstrated more rapid response to crisis. At the same time, expansion of national and transnational corporations has great influence on regional markets’ structures.
titanium–magnesium catalysts often used in polymerization processes

study by photoluminescence spectroscopy (PL) in combination with diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). The interaction of dibutyl phthalate (DBP) with MgCl2 was studied at DBP added /Mg = 0–1 (mol/mol). The luminescence spectra with excitation at 278 nm and the excitation spectra for main emission bands were recorded.

It was shown that DBP adsorbed on magnesium chloride, both in the form of donor–acceptor complexes (D + A – ) and in the form of molecular complexes. At DBP added /Mg <0.15, the formation of D + A – complexes occur predominantly; with an increase in DBP added /Mg, the fraction of molecular complexes increases. Molecular complexes are destroyed during the treatment of the support by TiCl4. In this case, the structure of magnesium chloride is disordered and new coordination–unsaturated sites are formed. The application of PL spectroscopy to such systems made it possible to detect interactions within and between donor molecules, which would be particularly challenging to achieve using other spectroscopic methods. Both spectroscopic methods provided crucial information about the existence of two types of complexes on the sample surface which is important for tuning the synthesis procedure of the titanium–magnesium catalysts for olefin polymerization.
Our purpose on the present occasion is to evaluate some ideas the biographers of late antiquity held about the origins of European thought. Speaking about this period we are no longer dealing with the question of transferring of the archaic practices: these practices are indeed long dead. What we encounter can be better defined as the import of ideas.

Equally important is a study of the changing attitudes of our authors: rather than passive witnesses, they became active participants of this import. The process is truly fascinating and we hope that the following examples, mostly from Hippolytus, will elucidate this. The best, almost a paradigmatic example is Pythagoras, who in late antiquity had many faces. His biography is an interesting instance of general change of attitude to ancient wisdom, typical for the source utilized by Hippolytus. Looking at a number of peculiar features of Hippolytus' report which, we hope, will help us to see why the image of Pythagoras and his philosophy, formed by Hippolytus, is somewhat untypical for the period.

We will see that Hippolytus' biographic report, however garbled, shows no signs of so-called 'Neopythagorean' biographic development. Admittedly, the later authors frequently combine their sources to make them suitable to their needs, polemical or apologetic. Do we still have a reason to believe that these stories, however doubtful from the historical point of view, may contain the germs of truth?