Hengzongshu/ArticleAgent huggingface dataset:
The article presents the result of the numerical simulation of the turbulent flow for a rib-step system by the RANS method at the Reynolds number, calculated by the step height and average flow rate velocity, Re = 5000. The data obtained in these studies showed the influence of divergence ratio on heat transfer in a flat channel with a transverse rib acting as a vortex generator. It is shown that with an increase in the divergence ratio, the length of the recirculation zone increases, while the position of the heat transfer maximum varies slightly.
The possibility of epitaxial growth of Pb 0.7 Sn 0.3 Te crystalline topological insulator films on the Si(111) surface was shown and epitaxial relations were found. It was shown that, depending on the growth temperature, it is possible to control not only the character of the morphology, but also, to a significant extent, the smoothness of the epitaxial layer surface.

Analysis of the grown films surface morphology made it possible to establish the average value of the height and lateral size of the terraces and islands forming Pb 0.7 Sn 0.3 Te surface.
In the present paper, we experimentally study the diffusive dynamics in ensembles of self-propelled and self-rotating bristle-bots. Considering the dependence of the system dynamics on the packing density of robots as well as on the friction between individual robots, we show that the friction slightly affects the diffusive dynamics but leads to a significant change in the jamming transition corresponding to the formation of rigid clusters of robots.
A search is presented for a heavy vector-like quark, decaying into a b quark and a W boson, which is produced singly in association with a light flavor quark and a b quark. The analysis is performed using a data sample of proton-proton collisions at a center-of-mass energy of sqrt(s) = 13 TeV collected at the LHC in 2015. The data set used in the analysis corresponds to an integrated luminosity of 2.3 inverse femtobarns. The search is carried out using events containing one electron or muon, at least one b-tagged jet with large transverse momentum, at least one jet in the forward region of the detector, and missing transverse momentum. No excess over the standard model prediction is observed. Upper limits are placed on the production cross section of heavy exotic quarks: a T quark with a charge of 2/3, and a Y quark with a charge of -4/3. For Y quarks with coupling of 0.5 and B(Y to bW) = 100%, the observed (expected) lower mass limits are 1.40 (1.0) TeV. This is the most stringent limit to date on the single production of the Y vector-like quark.
Hypertrophic cardiomyopathy (HCM) is one of the most frequent cardiovascular diseases but no methods to prevent its progression have been developed. Cardiomyocytes derived from patient-specific induced pluripotent stem cells can become a platform to study pathogenesis of the disease and to search for more effective therapy methods. We generated two iPSC lines from peripheral blood mononuclear cells of an HCM patient with heterozygous p.M659I mutation in MYH7 using episomal vectors. The iPSC lines expressed pluripotency markers, demonstrated ability to spontaneously differentiate into derivatives of three germ layers, and retained the mutation.
MOTIVATION: The commonly accepted statistical mechanical theory is now multiply confirmed by using the weight matrix methods successfully recognizing DNA sites binding regulatory proteins in prokaryotes. Nevertheless, the recent evaluation of weight matrix methods application for transcription factor binding site recognition in eukaryotes has unexpectedly revealed that the matrix scores correlate better to each other than to the activity of DNA sites interacting with proteins. This observation points out that molecular mechanisms of DNA/protein recognition are more complicated in eukaryotes than in prokaryotes. As the extra events in eukaryotes, the following processes may be considered: (i) competition between the proteins and nucleosome core particle for DNA sites binding these proteins and (ii) interaction between two synergetic/antagonist proteins recognizing a composed element compiled from two DNA sites binding these proteins. That is why identification of the sequence-dependent DNA features correlating with affinity magnitudes of DNA sites interacting with a protein can pinpoint the molecular event limiting this protein/DNA recognition machinery. RESULTS: An approach for predicting site activity based on its primary nucleotide sequence has been developed. The approach is realized in the computer system ACTIVITY, containing the databases on site activity and on conformational and physicochemical DNA/RNA parameters. By using the system ACTIVITY, an analysis of some sites was provided and the methods for predicting site activity were constructed. The methods developed are in good agreement with the experimental data. AVAILABILITY: The database ACTIVITY is available at http://wwwmgs.bionet.nsc.ru/systems/Activity/ and the mirror site, http://www.cbil.upenn.edu/mgs/systems/acti vity/.
We introduce a new method of the fabrication of surface nanoscale axial photonic (SNAP) microresonators through strong bending of an optical fiber. We experimentally demonstrate that geometric deformation and refractive index variation induced by bending is sufficient for the formation of a SNAP bottle resonator with nanoscale effective radius variation (ERV) along the fiber axis. In our experiment, we bend the optical fiber into a loop and investigate the properties of the fabricated tunable bottle resonator as a function of the loop dimensions. We find that the introduced ERV is approximately proportional to the local curvature of the loop, while the ERV maximum is proportional to the maximum of the loop curvature squared. The advantages of the demonstrated method are its simplicity, robustness, and ability to mechanically tune introduced resonant structures. This is of crucial importance for the creation of robust and tunable SNAP devices for applications in optical classical and quantum signal processing and ultraprecise sensing.
In this paper, on the basis of the Monte-Carlo simulation results

a signal processing algorithm for determination of the energy deposited in real time by incident particles has been developed and implemented in the created electronics prototype of the trigger system for an electromagnetic calorimeter of the COMET experiment. The energy thresholds for trigger cells are determined which make it possible to select signal events – an electron with a momentum of 105 MeV/c, and significantly reduce a rate of background events. The electronics prototype of the trigger system has been verified by testbench measurements and electron beam experiments.

The obtained results satisfy the key requirement of the calorimeter – the energy resolution in real time is better than 5 % for the signal electron energy.
Purpose. The article introduces single findings of bronze armament objects that were gathered in the course of an expeditionary journey during 1840–1843 on the territory of the Irtysh region (within the limits of southern steppe regions of Western Siberia, Altai Steppes and Eastern Kazakhstan) by a famous Russian scientist, botanist, officer of Saint Petersburg Botanical Gardens Alexander Gustav von Schrenck. Results. The archaeological objects gathered by the explorer are presently stored in the collection of the Peter the Great Museum of Anthropology and Ethnography of RAS in Saint Petersburg. They include various objects of armament and accessories of horse harness. The archaeological objects considered in the article are armament objects of close and hand-to-hand combats of ancient nomads. They are analyzed and classified on formal grounds according to the previously developed scientific methodology. The collection features a bronze spearhead with a bilobated feather and conical plug, a bronze dagger with a guard and a top and two bronze plug chisels with tetrahedral and circular peen and elongated butt ends. We provide some comments on chronology and the territory where similar objects were found in the sites of the Early Iron Age in Eurasian Steppe. Our classification is based on analogues of the objects studied, which were found at several archaeological sites on the contiguous territories of Southern Siberia and Central Asia. We also made certain assumptions on the cultural identity of the findings of the bronze armament objects of close and hand-to-hand combats which we analyzed. Conclusion. Having considered the analogues, we refer the objects of the ancient bronze weapon studied as a part of the museum collection and stored there, which were gathered on the territory of the Irtysh Region in the middle of the 19th century by A. G. von Schrenck, to the complex of battlefield assets of the ancient Eurasian Steppe nomads of Scythian times. The analysis provided and our introduction of these materials expands the range of available sources on armament and military science of the ancient nomadic population gathered by A. G. von Schrenck in several regions of Northern and Central Asia.
Confined carbon species play a dual role in the non-oxidative dehydroaromatization of methane over single-atom Mo/ZSM-5 catalysts. In their Communication on page 1016 ff., N. Kosinov, E. J. M. Hensen et al. applied operando spectroscopy, microscopy, and isotope labeling of methane to establish that polyaromatic hydrocarbons, formed in the micropores of the zeolite catalyst, are necessary intermediates for benzene formation. These species lead to catalyst deactivation by agglomeration in heavy deposits that block access to the pores.
The trivial lower bound for the 2-distance chromatic number χ 2 (G) of any graph G with maximum degree ∆ is ∆ + 1.It is known that χ 2 = ∆ + 1 if the girth g of G is at least 7 and ∆ is large enough.There are graphs with arbitrarily large ∆ and g ≤ 6 having χ 2 (G) ≥ ∆ + 2.

We prove the 2-distance 4-colorability of planar subcubic graphs with g ≥ 22.

We prove the 2-distance 4-colorability of planar subcubic graphs with g ≥ 22.
The Cryogenian geological record of Siberia is scarce and ambiguous. Late Neoproterozoic strata of presumed glaciogenic origin of the Marnya Formation, Oselok Group cropping out along the Uda River in the Eastern Sayan Ranges, south‐western Siberia has received considerable attention due to the presence of at least three distinctive diamictite units. The lower diamictite unit (Karapchetui Member) is in subvertical contact (previously interpreted as a glacial valley) with stratigraphically older strata of the Tagul and Ipsit formations of the Karagas Group, and is represented by a wedge‐shaped unit of breccia that hosts numerous ellipsoidal sandstone bodies (previously thought to be boulders). The boulders are here reinterpreted as early diagenetic quartz and feldspar‐cemented sandstone concretions exhumed and redeposited from the Ipsit Formation when the latter was still uncemented and easily erodible. Tectonic compression, reverse faulting and localised continuous syndepositional uplift led to exhumation of the concretions, whereas subsequent extension, reactivation of the fault and ‘negative inversion’ of the basin produced accommodation space for redeposition of the exhumed concretions. In the process of redeposition, exfoliating concretions produced abundant debris that provided clasts for the breccia deposit. The Karapchetui diamictite, therefore, can serve as a sedimentary archive of late Neoproterozoic tectonic activity at the south‐western margin of the Siberian Craton.
Identification of prognostic molecular markers of breast cancer is extremely important.The spreading out of the primary breast tumour cells to the lymphatic system is at the forefront of symbolising the first signs of distant organ metastasis.Deregulated genes in breast cancer tissues that spread to lymph nodes may show early predictive molecular markers.

In the present study, we selected five microRNAs, which play a key function in the invasion-metastasis cascade.We investigated the levels of microRNAs in 80 paired samples of BC and matched adjoining tissues, and we examined the potential relationships between microRNA levels and positive lymph node status.

Our results attest that three microRNAs (miR-21, miR-155, miR-222) were significantly up-regulated, whilst miR-205 was substantially down-regulated in BC tissues in relation to normal adjoining tissues in a heterogeneous patient cohort.The high levels of two microRNAs, miR-155 and miR-222, showed a statistical relation with the positive lymph node status, especially in patients that had triple negative BC. Conversely, miR-155 was substantially down-regulated in tumour tissues of patients who received preoperative neoadjuvant chemotherapy (NAC) compared with tumour tissues of patients without NAC in cohorts sub-classified to lymph node positive status.Our findings show evidence that the miR-155 and the miR-222 can be defined as molecular markers in regards to cancer patients to prognosticate spread to the lymph node.They also showed that the miR-155 could have crucial significances in BC treatment.
To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well as the genetic stability of individual tumours.

In this study, we describe a new axis between DNA repair and detoxification of aldehyde derivatives

with important implications for patient prognosis and treatment.
Bismuth-doped fibre amplifiers offer an attractive solution for expanding the bandwidth of fibre-optic telecommunication systems beyond the current C-band (1530-1565 nm).

We report a bismuth-doped fibre amplifier in the spectral range from 1370 to 1490 nm, with a maximum gain exceeding 31 dB, and a noise figure as low as 4.75 dB. The developed system is studied for forward, backward, and bi-directional pumping schemes and three different signal power levels.

The forward pumping scheme demonstrates the best performance in terms of the achieved noise figure. The developed amplifier can be potentially used as an in-line amplifier with >20dB gain in the spectral band from 1405 to 1460 nm.
The work was carried out in the period 2014-2017. The goal was set to create a new earlyripening variety with а high fodder and seed productivity, high protein content, and an even ripening of seeds.

The vetch cultivar Obskaya 16 was created by the method of hybridization on the basis of genetically different and ecologically-distant genotypes with subsequent multiple selection according to the specified parameters from the Kamalinskaya 611 × Novosibirskskaya hybrid populations.

The vetch cultivar Obskaya 16 combines early ripeness with high fodder and seed productivity. The length of the growing season of the new cultivar is, on average, 81 days, which allows for the production of certified seeds annually. During all the years of testing in breeding nurseries, the new cultivar surpassed the standard Kamalinskaya 611 in green mass by 41%, in dry matter by 40%, and in grain by 27%. This cultivar is of mowing type, its average seed yield is 2.43 t/ha, green mass 28 t/ha, dry matter – 5.82 t/ha. The main economic and valuable characteristics of the Obskaya 16 cultivar are as follows: the height of the stem is 85-120 cm, the number of internodes is 19-25, the height of attachment of the lower seed pods is 78 cm. The average number of seed pods per plant is 24, the maximum is 46, the average number of seeds per a seed pod is 7-8. The mass of 1000 seeds is 72.6 g. The colour of the seed coat is mainly black velvet (92%) and brown (8%). Crude protein content is 25.3–30.5%. In 2016 the cultivar of spring common vetch was passed to the state variety testing under the name Obskaya 16. The newly created cultivar surpasses the previously recognized varieties in the region by early ripeness, fodder and seed productivity, as well as high fodder quality.
Plasma wakefield dynamics over timescales up to 800 ps, approximately 100 plasma periods, are studied experimentally at the Advanced Wakefield Experiment (AWAKE). The development of the longitudinal wakefield amplitude driven by a self-modulated proton bunch is measured using the external injection of witness electrons that sample the fields. In simulation, resonant excitation of the wakefield causes plasma electron trajectory crossing, resulting in the development of a potential outside the plasma boundary as electrons are transversely ejected. Trends consistent with the presence of this potential are experimentally measured and their dependence on wakefield amplitude are studied via seed laser timing scans and electron injection delay scans.
Mesenchymal stem cells (MSCs) are considered as a promising tool for the treatment of inflammatory and degenerative diseases, but their effectiveness is associated with the survival of cells in an unfavorable microenvironment. Erythropoietin exhibits an anti-apoptotic effect for non-hematopoietic cells of the human and animal body.

The aim of the study was to evaluate the morphofunctional properties of MSCs cultured with erythropoietin. Material and methods. MSCs were obtained from bone marrow aspirate of patients with chronic heart failure. The primary culture of MSCs-EPO was obtained by growth MSCs of the 4th passage for 7-8 days with erythropoietin at a dose of 33 IU/mL. The phenotype, differentiation in the adipogenic and osteogenic directions, proliferation, migration, and production of nitric oxide of MSCs were studied.

The study revealed that the cultivation of MSCs with erythropoietin contributes to an increase in the expression of the main surface molecules that characterize the cells belonging to true MSCs, possess to differentiated of MSCs into adipocytes and osteoblasts, a change in the expression levels of adhesion molecules, a decrease in the level of apoptosis, increased cell migration during the induction of oxidative stress and hyperglycemia. Conclusion. Cultivation of MSCs with erythropoietin increases the resistance of cells to adverse microenvironment factors.
Microscopic images are widely used in plant biology as an essential source of information on morphometric characteristics of the cells and the topological characteristics of cellular tissue pattern due to modern computer vision algorithms. High-resolution 3D confocal images allow extracting quantitative characteristics describing the cell structure of leaf epidermis. For some issues in the study of cereal leaves development, it is required to apply the staining techniques with fluorescent dyes and to scan rather large fragments consisting of several frames. We aimed to develop a tool for processing multi-frame multi-channel 3D images obtained from confocal laser scanning microscopy and taking into account the peculiarities of the cereal leaves staining. We elaborated an ImageJ-plugin LSM-W2 that allows extracting data on Leaf Surface Morphology from Laser Scanning Microscopy images. The plugin is a crucial link in a workflow for obtaining data on structural properties of leaf epidermis and morphological properties of epidermal cells. It allows converting large lsm-files (laser scanning microscopy) into segmented 2D/3D images or tables with data on cells and/or nuclei sizes. In the article, we also represent some case studies showing the plugin application for solving biological tasks. Namely the plugin is applied in the following cases: defining parameters of jigsaw-puzzle pattern for maize leaf epidermal cells, analysis of the pavement cells morphological parameters for the mature wheat leaf grown under control and water deficit conditions, initiation of cell longitudinal rows, and detection of guard mother cells emergence at the initial stages of the stomatal morphogenesis in the growth zone of a wheat leaf. The proposed plugin is efficient for high-throughput analysis of cellular architecture for cereal leaf epidermis. The workflow implies using inexpensive and rapid sample preparation and does not require the applying of transgenesis and reporter genetic structures expanding the range of species and varieties to study. Obtained characteristics of the cell structure and patterns further could act as a basis for the development and verification for spatial models of plant tissues formation mechanisms accounting for structural features of cereal leaves. The implementation of this workflow is available as an ImageJ plugin distributed as a part of the Fiji project (FijiisjustImageJ: https://fiji.sc/ ). The plugin is freely available at https://imagej.net/LSM_Worker , https://github.com/JmanJ/LSM_Worker and http://pixie.bionet.nsc.ru/LSM_WORKER/ .
Four new gadolinium(III) metal-organic frameworks containing 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen) chelate ligands and trans-1,4-cyclohexanedicarboxylate (chdc2−) were synthesized. Their crystal structures were determined by single-crystal X-ray diffraction analysis. All four coordination frameworks are based on the binuclear carboxylate building units. In the compounds [Gd2(bpy)2(chdc)3]·H2O (1) and [Gd2(phen)2(chdc)3]·0.5DMF (2), the six-connected {Ln2(L)2(OOCR)6} blocks form a 3D network with the primitive cubic (pcu) topology. In the compounds [Gd2(NO3)2(phen)2(chdc)2]·2DMF (3) and [Gd2Cl2(phen)2(chdc)2]·0.3DMF·2.2dioxane (4), the four-connected {Ln2(L)2(X)2OOCR)4} units (where X = NO3− for 3 or Cl− for 4) form a 2D square-grid (sql) network.

The solid-state luminescent properties were investigated for the synthesized frameworks. Bpy-containing compound 1 shows no luminescence, possibly due to the paramagnetic quenching by Gd3+ cation. In contrast, the phenathroline-containing MOFs 2–4 possess yellow emission under visible excitation (λex = 460 nm) with the tuning of the characteristic wavelength by the coordination environment of the metal center.
The psychopathological features of patients with excoriated acne are analysed. An integrative anx-iety test among 43 patients (mean age 24.7±7.1 years) demonstrated borderline values and a high level of personal anxiety in 46.5% of cases; assessment according to the Beck Depression Inventory revealed subdepression among 25.6% and depression among 13.9% of patients; the Global Severity Index (GSI) of the Symptom Checklist-90-R (SCL-90-R) was in the zone of elevated and high val-ues among 31.1% of patients. The greatest deviations from the norm were observed in the areas of interpersonal sensitivity among 34.9% of patients; dev phobic anxiety – 30.2%; paranoia – 30.2%; while somatisation of complaints was observed among 27.9% of patients. The obsessive-compulsive subscale exceeded normative values among 21% of patients.
The Zarnitsa kimberlite pipe is one of the largest pipes of the Yakutian diamondiferous province. Currently, some limited published data exists on the diamonds from this deposit. Among the diamond population of this pipe there is a specific series of dark gray to black diamonds with transition morphologies between octahedron and rounded rhombic dodecahedron. These diamonds have specific zonal and sectorial mosaic-block internal structures. The inner parts of these crystals have polycrystalline structure with significant misorientations between sub-individuals. The high consistency of the mechanical admixtures (inclusions) in the diamonds cores can cause a high grid stress of the crystal structure and promote the block (polycrystalline) structure of the core components. These diamond crystals have subsequently been formed due to crystallization of bigger sub-individuals on the polycrystalline cores according to the geometric selection law.