Hengzongshu/ArticleAgent huggingface dataset:
The $e^+ e^- \to K^0_{S}K^0_{L}$ cross section has been measured in the center-of-mass energy range 1004--1060 MeV at 25 energy points using $6.1 \times 10^5$ events with $K^0_{S}\to π^+π^-$ decay. The analysis is based on 5.9 pb$^{-1}$ of an integrated luminosity collected with the CMD-3 detector at the VEPP-2000 $e^+ e^-$ collider.

To obtain $ϕ(1020)$ meson parameters the measured cross section is approximated according to the Vector Meson Dominance model as a sum of the $ρ, ω, ϕ$-like amplitudes and their excitations.

This is the most precise measurement of the $e^+ e^- \to K^0_{S}K^0_{L}$ cross section with a 1.8\% systematic uncertainty.
We report the observation of two narrow structures in the mass spectra of the pi+-Y(nS) (n=1,2,3) and pi+-hb(mP)(m$ (m=1,2) pairs that are produced in association with a single charged pion in Y(5S) decays. The measured masses and widths of the two structures averaged over the five final states are M_1=(10607.2+-2.0) MeV/c2, Gamma_1=(18.4+-2.4) MeV and M_2=(10652.2+-1.5) MeV/c2, Gamma_2=(11.5+-2.2) MeV. The results are obtained with a 121.4 1/fb data sample collected with the Belle detector in the vicinity of the Y(5S) resonance at the KEKB asymmetric-energy e+e- collider.
The data and methods presented in this article are supplementing the research article "Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis", DOI: 10.1016/j.mito.2016.12.001 (Gunbin et al., 2017) [1]. Mitochondrial DNA is known to get inserted into nuclear DNA to form NUMTs, i.e. nuclear DNA pseudogenes of the mtDNA. We present here the sequences of selected NUMTs, in which time of integration can be determined with sufficient precision. We report their chromosomal positions , their position within the great ape mtDNA phylogeny, and their times of integration into the nuclear genome. The methods used to generate the data and to control their quality are also presented. The dataset is made publicly available to enable critical or extended analyzes.
Aim To study blood adipokines spectrum in people aged 25-44 years with early ischemic heart disease (IHD), including that associated with abdominal obesity (AO).Material and methods A cross-sectional study was performed on a random sample of the population aged 25-44 years in Novosibirsk. 1457 subjects (653 men, 804 women) were evaluated. This study included 123 people divided into four study subgroups: subgroup 1, with IHD associated with AO (n=24); subgroup 2, with IHD and without AO (n=25); subgroup 3, without IHD and with AO (n=44); and subgroup 4, without either IHD or AO (n=30). Concentrations of serum adipokines were measured simultaneously by multiplex assay with a Luminex MAGPIX flow fluorometer and by immune enzyme assay with a MULTISCAN analyzer.Results Subjects with early IHD had lower blood concentrations of adipsin and visfatin than subjects without IHD. Subjects with early IHD associated with AO had higher blood concentrations of adipsin, plasminogen activator inhibitor-1, and leptin and lower concentrations of monocyte chemoattractant protein-1 (MCP-1) and visfatin compared to subjects with early IHD and without AO. The multivariate logistic regression analysis showed that lower blood concentrations of MCP-1 were associated with a likelihood of early IHD.Conclusion In young people aged 25-44 years, lower blood concentrations of MCP-1 were associated with a likelihood of early IHD, including that associated with AO.
The nonlinear Schrödinger equation (NLSE) is often used as a master path-average model for fiber-optic links to analyze fundamental properties of such nonlinear communication channels. Transmission of a signal in nonlinear channels is conceptually different from linear communications.

We use here the NLSE channel model to explain and illustrate some new unusual features introduced by nonlinearity. In general, NLSE describes the co-existence of dispersive (continuous) waves and localized (here in time) waves: soliton pulses. The nonlinear Fourier transform method allows one to compute for any given temporal signal the so-called nonlinear spectrum that defines both continuous spectrum (analog to conventional Fourier spectral presentation) and solitonic components. Nonlinear spectrum remains invariant during signal evolution in the NLSE channel. Applying Zakharov-Shabat spectral problem to a single WDM or OFDM symbol with multiple sub-carriers, we quantify the effect of statistical occurrence of discrete eigenvalues in such an information-bearing optical signal.

We examine conventional orthogonal frequency-division multiplexing (OFDM) and wavelength-division multiplexing (WDM) return-to-zero signals and demonstrate that both signals at certain power levels have soliton component. We would like to stress that this effect is completely different from the soliton communications studied in the past. Moreover, we observe that at signal powers optimal for transmission, an OFDM symbol with high probability has a soliton component.
Surface- and tip-enhanced resonant Raman scattering (resonant SERS and TERS) by optical phonons in a monolayer of CdSe quantum dots (QDs) is demonstrated.

The SERS enhancement was achieved by employing plasmonically active substrates consisting of gold arrays with varying nanocluster diameters prepared by electron-beam lithography. The LSPR positions as a function of nanocluster diameter were experimentally determined from spectroscopic micro-ellipsometry, and compared to numerical simulations showing good qualitative agreement. The monolayer of CdSe QDs was deposited by the Langmuir-Blodgett-based technique on the SERS substrates. By tuning the excitation energy close to the band gap of the CdSe QDs and to the LSPR energy, resonant SERS by longitudinal optical (LO) phonons of CdSe QDs was realized.

A SERS enhancement factor of 2 × 10(3) was achieved. This allowed the detection of higher order LO modes of CdSe QDs, evidencing the high crystalline quality of QDs. The dependence of LO phonon mode intensity on the size of Au nanoclusters reveals a resonant character, suggesting that the electromagnetic mechanism of the SERS enhancement is dominant. Finally, the resonant TERS spectrum from CdSe QDs was obtained using electrochemically etched gold tips providing an enhancement on the order of 10(4). This is an important step towards the detection of the phonon spectrum from a single QD.
The Free Electron Laser (FEL) based on multi-turn microtron-recuperator is currently operating in Novosibirsk. For successful operation of the facility, a specialized control system was developed. The software part of this system consists of a set of different program modules. For ensuring program connection between a client and server parts of the control software, the Channel Access protocol from the EPICS framework was employed. Features and examples of using this protocol without utilizing the whole EPICS system are described in this article.
The Olkhon terrane in the Western Baikal area accommodates four types of carbonate-silicate mixtures: injection (protrusion), metamorphic-boudinated, mingling, and tectonite marble mélange.

The outcrops of injection mélange consist of a carbonate matrix with inclusions of native silicic rocks found in the immediate vicinities, commonly cover large areas and lack any distinct linearity in the map view. Mélange of the metamorphic boudinage type comprises diopsidite and tremilote-diopsidite fragments in a dolomitic or calcite-dolomitic matrix. Mingling mélange appears as calcite marble or carbonate-silicate (calciphyre) veins with metadolerite and granite inclusions of different sizes. The veins formed by intrusion of carbonate and silicate melt batches and subsequent fragmentation of silicate rocks that crystallized earlier.

Its origin is apparently due to tectonism and related metamorphism of quartz sandstones in Neoproterozoic strata on the passive margin of the Siberian craton. Marble tectonites localized in narrow zones record the late phase of ductile marble injection.
The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level.

Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes or their segments or particular genes within the genome, and therefore to modify the set, position and copy number of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide a possibility to introduce into genome relatively large segments of alien chromosome material, either artificially constructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transfer whole chromosomes or their fragments between different genomes within and between species.

Advantages and limitations of these approaches are discussed.
Bread wheat ( Triticum aestivum L.) is one of the most important agricultural plants wearing abiotic stresses, such as water deficit and cold, that cause its productivity reduction. Since resistance to abiotic factors is a multigenic trait, therefore modern genome-wide approaches can help to involve various genetic material in breeding. One technique is full transcriptome analysis that reveals groups of stress response genes serving marker-assisted selection markers.

Comparing transcriptome profiles of the same genetic material under several stresses is essential and makes the whole picture. Here, we addressed this by studying the transcriptomic response to water deficit and cold stress for two evolutionarily distant bread wheat varieties: stress-resistant cv. Saratovskaya 29 (S29) and stress-sensitive cv. Yanetzkis Probat (YP). For the first time, transcriptomes for these cultivars grown under abiotic stress conditions were obtained using Illumina based MACE technology.

We identified groups of genes involved in response to cold and water deficiency stresses, including responses to each stress factor and both factors simultaneously that may be candidates for resistance genes. We discovered a core group of genes that have a similar pattern of stress-induced expression changes. The particular expression pattern was revealed not only for the studied varieties but also for the published transcriptomic data on cv. Jing 411 and cv. Fielder. Comparative transcriptome profiling of cv. S29 and cv. YP in response to water deficit and cold stress confirmed the hypothesis that stress-induced expression change is unequal within a homeologous gene group. As a rule, at least one changed significantly while the others had a relatively lower expression. Also, we found several SNPs distributed throughout the genomes of cv. S29 and cv. YP and distinguished the studied varieties from each other and the reference cv. Chinese Spring. Our results provide new data for genomics-assisted breeding of stress-tolerant wheat cultivars.
We study experimentally the propagation of internal waves in two different three-dimensional (3D) geometries, with a special emphasis on the refractive focusing due to the 3D reflection of obliquely incident internal waves on a slope.

Both studies are initiated by ray tracing calculations to determine the appropriate experimental parameters. First, we consider a 3D geometry, the classical set-up to get simple, 2D parallelogram-shaped attractors in which waves are forced in a direction perpendicular to a sloping bottom. Here, however, the forcing is of reduced extent in along-slope, transverse direction. Direct numerical simulations confirm the dynamics, emphasize the role of boundary conditions and reveal the phase shifting in the transversal direction. Second, we consider a long and narrow tank having an inclined bottom, to simply reproduce a canal. In this case, the energy is injected in a direction parallel to the slope.

We show how the refractive focusing mechanism explains the formation of attractors over the whole width of the tank, even away from the forcing region. Interestingly, the wave energy ends up forming 2D internal wave attractors in planes that are transverse to the initial propagation direction. This focusing mechanism prevents indefinite transmission of most of the internal wave energy along the canal.
The cross-section for inclusive phi meson production in pp collisions at a centre-of-mass energy of sqrt(s) = 7 TeV has been measured with the LHCb detector at the Large Hadron Collider. The differential cross-section is measured as a function of the phi transverse momentum p_T and rapidity y in the region 0.6 phi X) = 1758 pm 19(stat) ^{+43}_{-14}(syst) pm 182(scale) microbarn, where the first systematic uncertainty depends on the p_T and y region and the second is related to the overall scale. Predictions based on the Pythia 6.4 generator underestimate the cross-section.
The results of experiments to assess the possible influence on seismic safety of structures of seasonal changes in the natural frequencies of the underlying soils are given.

It is shown that the resonance properties of the surface soil layer during the year can vary more significantly than the properties of the structures built on them.

This can lead to the coincidence of natural frequencies of the soil layer and the structures standing on it, which ultimately reduces their seismic safety.
Long-term data on flowering phenology of 9 Campanula L. species were processed using computer modeling. Modified model is proposed to describe flowering of monocarpic shoots with multi-flowered inflorescences taking into account structural inflorescence features and morphogenesis of floral zone. The flowering patterns are determined by degree of inflorescence branching and sequence of flowers opening in them. It is shown that flowering curve for simple inflorescences is unimodal: it has single peak associated with opening of terminal flower and flowers on the 1st order axes. For compound inflorescences two maxima are noted (the second of them is due to opening of flowers on the 2nd order axes), or curve has wavy character. Regression curves describing sequence of flowers opening on the 1 st order axes are different. They are C-shaped if flowering begins in lower third of the inflorescence and then spreads divergently. More often terminal flower opens first, and is accompanied by several flowers in lower third of inflorescence, while next flowers open in divergent way. In this case the regression curves are S-shaped. The proposed model reproduces picture of individual flowering with natural variability, and can be used to describe flowering of various taxa of herbaceous plants with multi-flowered inflorescences.
Most young patients with hyperglycemia have type 1 diabetes and type 2 diabetes but up to 10% of all cases of the disease occur in MODY (Maturity Onset Diabetes of the Young). Published abstracts show features of the debut, laboratory and genetic characteristics of MODY in the Russian population. However there is a small amount of data on the clinical course of this nosology in the Russian Federation.

Aim: To investigate the characteristics of the 3-year course of GCK-MODY diagnosed after 18 years. Materials and methods : 85 probands and 46 relatives of the first and second degrees of kinship with a clinical diagnosis of GCK-MODY were examined: biochemical and hormonal blood tests, ultrasound, molecular genetic studies. Patients were invited for a follow-up visit 3 years after verification of the pathogenic mutations associated with GCK-MODY. Examination, biochemical and hormonal analyzes , ultrasound were done in second visit.

Results: The diagnosis GCK-MODY was verified by a molecular genetic study in 25 probands (29.4%). In 33 of 46 (71.7%) relatives of patients with GCK-MODY were diagnosed identical mutations. In 31 patients with GCK-MODY diagnosed after 18 years, a dynamic observation was performed for three years. Most patients over 18 years of age did not have clinical manifestations of carbohydrate metabolism disorders when diagnosing GCK-MODY and follow up visit. Skin rashes and allergic reactions prevailed among concomitant pathologies. Patients with GCK-MODY had preserved β-cell secretion, HbA1c targets were achieved. Low fasting hyperglycemia prevailed which persisted even after treatment correction. Among the characteristics of carbohydrate metabolism, biochemical, lipid and hormonal parameters during GCK-MODY verification and after three years of observation no significant differences were obtained, which indicates a stable course of the disease. Half of the patients achieved normoglycemia by rational nutrition, two people with GCK-MODY within three years after determining the diagnosis were transferred from insulin therapy to oral glucose-lowering drugs. Among oral glucose-lowering drugs prior to GCK-MODY verification most patients used metformin, 3 years later — dipeptidyl peptidase-4 inhibitors. Conclusion. The results of a three-year follow-up of a group of patients with GCK-MODY demonstrate a non-progressive course of this type of diabetes with stable indicators of carbohydrate metabolism and low fasting hyperglycemia that persists after 3 years of observation. With the verification of GCK-MODY and the achievement of the target values of glycated hemoglobin and postprandial glycaemia by rational nutrition, even if a low level of fasting hyperglycemia is determined, the prescription of oral glucose-lowering drugs is not indicated in most cases.
Earlier, GLIS3 gene polymorphisms have been shown to be associated with the development of maturity onset diabetes of the young (MODY).

We screened GLIS3 gene sequences among patients with MODY to identify probably pathogenic variants by whole-exome sequencing. We estimated frequency of rare single-nucleotide variants in the coding region of GLIS3 in a Caucasian population and among individuals with carbohydrate metabolism disorders in Russia. We identified 15 single-nucleotide variants in GLIS3. Three rare variants (minor allele frequency < 1%) rs806052, rs143051164, and rs149840771 were genotyped in 126 cases of MODY, in 188 patients with type 2 diabetes mellitus (DM2), and 564 randomly selected Caucasian individuals in Russia.

A heterozygous rs806052 variant was identified in one patient with DM2; c.1270T frequency was 0.003. Prevalence of rs143051164 c.844G was 0.003 in the control population and 0.004 and 0.003 in MODY and DM2 samples, respectively. Prevalence of rs149840771 c.2096A was 0.003 and 0.004 in the control population and among MODY patients, respectively. In DM2 patients, rs149840771 c.2096A was not identified. We did not detect any associations of rs806052, rs143051164, and rs149840771 with carbohydrate metabolism disorders among patients with MODY and DM2 in Russia.
In the present study behavioral effects of the 5-HT 2C serotonin receptor were investigated in different mouse strains.

The 5-HT 2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT 2C receptor antagonist RS102221. To study the role of genotype in 5-HT 2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We also compared the interstrain differences in functional response to 5-HT 2C and 5-HT 2A receptors activation measured by the quantification of receptor-mediated head-twitches. Moreover, we found that 5-HT 2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice.

We found that the 5-HT 2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Taken together, our data indicate the implication of the 5-HT 2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT 2C and 5-HT 2A receptors.
Hybrid sterility is an important step in the speciation process. Hybrids between dwarf hamsters Phodopus sungorus and P. campbelli provide a good model for studies in cytological and genetic mechanisms of hybrid sterility. Previous studies in hybrids detected multiple abnormalities of spermatogenesis and a high frequency of dissociation between the X and Y chromosomes at the meiotic prophase. In this study, we found that the autosomes of the hybrid males and females underwent paring and recombination as normally as their parental forms did. The male hybrids showed a significantly higher frequency of asynapsis and recombination failure between the heterochromatic arms of the X and Y chromosomes than the males of the parental species. Female hybrids as well as the females of the parental species demonstrated a high incidence of centromere misalignment at the XX bivalent and partial asynapsis of the ends of its heterochromatic arms. In all three karyotypes, recombination was completely suppressed in the heterochromatic arm of the X chromosome, where the pseudoautosomal region is located. We propose that this recombination pattern speeds up divergence of the X- and Y-linked pseudoautosomal regions between the parental species and results in their incompatibility in the male hybrids.
Pre-eclampsia is the most common complication occurring during pregnancy. In the majority of cases, it is concurrent with other pathologies in a comorbid manner (frequent co-occurrences in patients), such as diabetes mellitus, gestational diabetes and obesity. Providing bronchial asthma, pulmonary tuberculosis, certain neurodegenerative diseases and cancers as examples, we have shown previously that pairs of inversely comorbid pathologies (rare co-occurrences in patients) are more closely related to each other at the molecular genetic level compared with randomly generated pairs of diseases. Data in the literature concerning the causes of pre-eclampsia are abundant. However, the key mechanisms triggering this disease that are initiated by other pathological processes are thus far unknown. The aim of this work was to analyse the characteristic features of genetic networks that describe interactions between comorbid diseases, using pre-eclampsia as a case in point. The use of ANDSystem, Pathway Studio and STRING computer tools based on text-mining and database-mining approaches allowed us to reconstruct associative networks, representing molecular genetic interactions between genes, associated concurrently with comorbid disease pairs, including pre-eclampsia, diabetes mellitus, gestational diabetes and obesity. It was found that these associative networks statistically differed in the number of genes and interactions between them from those built for randomly chosen pairs of diseases. The associative network connecting all four diseases was composed of 16 genes (PLAT, ADIPOQ, ADRB3, LEPR, HP, TGFB1, TNFA, INS, CRP, CSRP1, IGFBP1, MBL2, ACE, ESR1, SHBG, ADA). Such an analysis allowed us to reveal differential gene risk factors for these diseases, and to propose certain, most probable, theoretical mechanisms of pre-eclampsia development in pregnant women. The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or INS]-[NOS3]-[pre-eclampsia]; [INS]-[HSPA4 or CLU]-[pre-eclampsia]; [ACE]-[MTHFR]-[pre-eclampsia]. For pre-eclampsia, diabetes mellitus, gestational diabetes and obesity, we showed that the size and connectivity of the associative molecular genetic networks, which describe interactions between comorbid diseases, statistically exceeded the size and connectivity of those built for randomly chosen pairs of diseases. Recently, we have shown a similar result for inversely comorbid diseases. This suggests that comorbid and inversely comorbid diseases have common features concerning structural organization of associative molecular genetic networks.