Hengzongshu/ArticleAgent huggingface dataset:
Familial hypercholesterolemia (FH) is a monogenic disease, leading to atherosclerosis due to a high level of low-density lipoprotein cholesterol. Most cases of the disease are based on pathological variants in the LDLR gene. Hepatocyte-like and endothelial cells derived from individual iPSCs are a good model for developing new approaches to therapy. We obtained an iPSC line from peripheral blood mononuclear cells of the patient with compound heterozygous p.Ser177Leu/p.Cys352Arg mutation in LDLR using non-integrating vectors. The iPSCs with a confirmed patient-specific mutation demonstrate pluripotency markers, normal karyotype, and the ability to differentiate into derivatives of three germ layers.
We report the observation of B(s)⁰→J/ψf₀(980) and evidence for B(s)⁰→J/ψf₀(1370), which are CP eigenstate decay modes. These results are obtained from 121.4 fb⁻¹ of data collected at the Υ(5S) resonance with the Belle detector at the KEKB e(+)e⁻ collider. We measure the branching fractions B(B(s)⁰→J/ψf₀(980); f₀(980)→π(+)π⁻)=(1.16(-0.19)(+0.31)(stat)(-0.17)(+0.15)(syst)(-0.18)(+0.26)(N(B(s)((*))B(s)((*)))))×10⁻⁴ with a significance of 8.4σ, and B(B(s)⁰→J/ψf₀(1370); f₀(1370)→π(+)π⁻)=(0.34(-0.14)(+0.11)(stat)(-0.02)(+0.03)(syst)(-0.05)(+0.08)(N(B(s)((*))B(s)((*)))))×10⁻⁴ with a significance of 4.2σ. The last error listed is due to uncertainty in the number of produced B(s)((*))B(s)((*)) pairs.
usually discussed more complex conditions

find a set of necessary and sufficient conditions for the CP conservation in the most general 2HDM in terms of observable quantities

This set contains two simple and relatively easily testable conditions
This work is aimed to the investigation of the influence of a slots depth on disturbances in a hypersonic boundary layer.

Experimental investigations of the influence of the surface consist of streamwise slots on development of second mode disturbances in the hypersonic boundary layer are conducted on the sharp cone at Mach number M∞ = 5.9. Numerical simulation of an interaction of the ultrasonic acoustic wave with surfaces with slots, which are used in experiments, are performed.

The experiments show that second mode disturbances are dumped on surfaces with slots. The optimum slots depth is found.
The opening of the Xpress beamline [1] in 2016 has provided the high-pressure diffraction user community of the Elettra synchrotron facility a dedicated experimental set up at their disposal.This new beamline is part of a scientific partnership between India and Italy under a project administered through the Indian Institute of Sciences (IISc) Bangalore, for the development of a macromolecular and a high-pressure x-ray diffraction facilities, respectively XRD2 [2] and Xpress.A multipole superconducting wiggler (SCW) is the source of these two beamlines.

A liquid nitrogen cooled silicon single crystal (cut along the (111) direction) hosted in the splitter chamber in the Front-End section intercepts the beam from the source (SCW) and directs it to the focusing mirror of the Xpress at a fixed energy of 25 keV.At this energy, the SCW provides a factor of 14 higher photon flux compared to the permanent magnet wiggler of XRD1, the existing diffraction beamline.The beam is focused using a toroidal mirror of 1.4 m long and 2.9 mrad grazing angle with a Pt coating to achieve 80% reflectivity at 25 keV.The focused beam from the mirror is further optimized by collimators (presently 80 micron diameter) to have intense and well defined monochromatic beam required for the high-pressure x-ray diffraction experiments.On-line pressure monitoring is achieved through a ruby fluorescence microscope connected side-by-side to the final beam collimator stage.

The present experimental stage is equipped to host room temperature -high-pressure powder diffraction measurements using various kinds of Diamond Anvil Cells (DAC) in the pressure range 0-50 GPa.An image plate MAR345, with a controllable linear movement along the beam direction at two fixed vertical positions, is available for recording the diffraction pattern from both powder and single crystal samples.A Gas loading system is under commissioning, while variable temperature (300 -100 K) capillary powder diffraction stage and limited range low-temperature high-pressure measurements using a specialized DAC and liquid nitrogen cryocooler system are also planned to be added in the near future.
Introduction. The attachment is viewed as the base for assessment of individual adaptation variation throughout life. In the capacity of the core indicator of the person’s unison with external environment, the psychological well-being combines the different aspects of child life. The assessment of the psychological well-being is based on three indicators: evidence of life satisfaction; life quality assessment; difficulty levels of external and internal spectrum. The aim of the current publication is to investigate the influence of features of attachment to mother on psychological well-being of primary school-age children. Methodology and research methods. The methodological research framework was based on the main provisions of the attachment theory (J. Bowlby, M. Ainsworth). “Mother-Child Attachment Style Measure Questionnaire” method (Pupyreva, 2007) was employed to identify attachment features. The measure of psychological well-being was carried out by means of “Student’s Life Satisfaction Scale” (Toporkova, Slobodskaya et al., 2015), “Pediatric Quality of Life Inventory” and “Strength and Difficulties Questionnaire” (Goodman, Slobodskaya, Knyazev, 2005) methods. 178 primary school-age children (85 boys and 93 girls) aged 10 to 11 (mean age = 10.2) participated in the research. Results. The analysis of the results showed that secure attachment among children reduces life satisfaction, facilitates the behavioural disorders and psycho-emotional reactions, impacts on limitation of social contacts and life quality. Using the regression analysis, it was revealed that the quality of the correlation between attachment indicators and psychological well-being vary depending on degree of attachment security. It is demonstrated that maternal responsiveness and attentiveness is an absolute predictor of life satisfaction, physical and social well-being and life quality in the primary school-age period, irrespective of the child’s attachment types. The absence of mother-child closeness is the predictor for disruption of physical, emotional and social functioning, low level of life quality in insecure attachment in primary school-aged children. Scientific novelty. The specificity of psychological well-being of primary school-aged children with different types of attachment to their mother is determined. It is shown for the first time that characteristics of attachment are the predictors of life satisfaction, quality of life, and mental health of primary school-aged children. Practical significance. By identifying different regression models for the description of psychological well-being on the basis of child-mother attachment indicators, it may be possible to provide interventions to improve psychological well-being based on the characteristics of attachment.
We use numerical simulations of the reactive Euler equations to analyse the nonlinear stability of steady-state one-dimensional solutions for gaseous detonations in the presence of both momentum and heat losses.

Our results point to a possible stabilization mechanism for the low-velocity detonations in such systems.

The mechanism stems from the existence of a one-parameter family of solutions found in Semenko et al. ( Shock Waves , vol. 26 (2), 2016, pp. 141–160).
A model of the polarization of dust particles with trapped ions in an external electric field is presented. It is based on the self-consistent solution of the integral balance equation for trapped ion density and Poisson equation for the electric potential. It is shown that, in a low collisional regime, trapped ions form a spread shell with a maximum located at some distance from thecharged dust particle proportional to the ion Debye length. The estimated polarizability of dusty "quasiatoms" is very high anddepends on the strength of the external electric field due to the field ionization of trapped ions. With increase in the electricfield, the dusty "quasiatom" loses their trapped ions from far orbits due to the field ionization. The radius of the dusty "quasiatom" ionic shell becomes smaller, and the coefficient of polarizability decreases.
Findings from mendelian randomisation analyses were then compared against results from traditional observational studies (164 170 participants).

Mendelian randomisation study, using genetic data as proxies for education to minimise confounding. The main analysis used genetic data from two large consortia (CARDIoGRAMplusC4D and SSGAC), comprising 112 studies from predominantly high income countries. Finally, genetic data from six additional consortia were analysed to investigate whether longer education can causally alter the common cardiovascular risk factors. Participants: The main analysis was of 543 733 men and women (from CARDIoGRAMplusC4D and SSGAC), predominantly of European origin. Exposure: A one standard deviation increase in the genetic predisposition towards higher education (3.6 years of additional schooling), measured by 162 genetic variants that have been previously associated with education. Main outcome measure: Combined fatal and non-fatal coronary heart disease (63 746 events in CARDIoGRAMplusC4D).

This mendelian randomisation study found support for the hypothesis that low education is a causal risk factor in the development of coronary heart disease. Potential mechanisms could include smoking, body mass index, and blood lipids. In conjunction with the results from studies with other designs, these findings suggest that increasing education may result in substantial health benefits.
Anthropometric traits are of global clinical relevance as risk factors for a wide range of disease, including obesity. Yet despite many hundreds of genetic variants having been associated with anthropometric measurements, these variants still explain little variation of the traits.

Here, we develop a simple method to perform multi-trait meta-GWAS using summary statistics reported in standard single-trait meta-GWAS and replicate the findings in an independent cohort. Using the summary statistics reported by the GIANT consortium meta-GWAS of 270,000 individuals, we discovered 359 novel loci significantly associated with six anthropometric traits.

The novel variants had an enriched rediscovery rate in the replication cohort. Our results provide new important insights into the biological mechanisms underlying anthropometric traits and emphasize the value of combining multiple correlated phenotypes in genomic studies. Our method has general applicability and can be applied as a secondary analysis of any standard GWAS or meta-GWAS with multiple traits.
Using the density matrix formalism, we prove the existence of the periodic steady state for an arbitrary periodically driven system described by linear dynamic equations. This state has the same period as the modulated external influence, and it is realized as an asymptotic solution $(t\rightarrow+\infty)$ due to relaxation processes.

The presented derivation simultaneously contains a simple and effective computational algorithm (without using either the Floquet or Fourier formalisms), which automatically guarantees a full account of all frequency components. As a particular example, for three-level $\mathrm{\Lambda}$ system we calculate the line shape and field-induced shift of the dark resonance formed by the field with a periodically modulated phase. Also we have analytically solved a basic theoretical problem of the direct frequency comb spectroscopy, when the two-level system is driven by the periodic sequence of rectangular pulses.

In this case, the radical dependence of the spectroscopy line shape on pulse area is found. Moreover, the existence of quasiforbidden spectroscopic zones, in which the Ramsey fringes are significantly reduced, is predicted. Our results have a wide area of applications in laser physics, spectroscopy, atomic clocks, and magnetometry. Also they can be useful for any area of quantum physics where periodically driven systems are considered.
In this study we analyze the applicability of specific machine learning algorithms to the task of detecting sentences containing argumentation in Russian text. We employ a collection of scientific and popular science texts with manually annotated argumentation to evaluate the quality of identifying argumentative sentences in terms of precision, recall, and F -measure. The experiment involves three algorithms: MNB, SVM, and MLP. The bag of words model is used for representing texts. Lemmas of words in analyzed sentences serve as features for the classification. We perform the automatic selection of informative features in accordance with Variance and χ 2 criteria combined with the weight-based filtration of lemmas (via TF*IDF and EMI). The training set includes around 800 sentences, while the test set contains 180. The MNB algorithm demonstrates the highest F -measure and recall scores on almost all feature sets (maximal values reached equal 68.7% and 89% respectively), while the MLP algorithm shows the best precision for about half of feature selection variations (the maximal value is 72.5%).
The article focuses on the need to consider classical medieval texts not only as sources of historical information, but also as author's works subject to a certain methodology and using a variety of historiographical technologies and ideological schemes.

The specific subject of the study is the two main sources on the history of the Eastern and Western Khitans ("Khitan Guo Chi" / "History of the Khitan state" and "Liao Shi" / "History of the [dynasty] Liao"), who created the largest state structures in the pre-Mongol period. "Khian Guo Zhi" is more of a history of the Khitan ethnos, whereas "Liao Shi" is a history of the dynasty, i.e., of the state construction. Their authors carried out impressive synthetic work to prove certain postulates. These are, strictly speaking, not scientific approaches, but ideological, existing, moreover, often in the form of Philistine fabrications. These sources raise a particularly significant problem of the origin of the Khitan, their dynasty, civilizational affiliation of the Khitan, the Khitan determination of the place in a nomadic world, the specifics of socio-economic and social system of the state of Liao, Khitan influence on the social development of the far East and East Asian regions. In them, the Chinese civilizational paradigm was applied to the fullest extent possible, the essential worldview settings of classical Chinese historiography are traced: Sino-centrism, sedentary centrism, Han-fan dichotomies and culture – nature.

As a result, we have the maximum possible penetration in those days into the two most important topics-the people as a geopolitical actor and the state as a civilizational-state structure. As a result, these works had a significant impact on the development of the two most common approaches to studying the history of Khitan, which are considered as classical barbarians who constantly attacked China and for this purpose created their own quasi-state, but under the influence of Chinese civilization "grew" to the level of the traditional dynasty.
The evolution of the spatial form of the flow versus the Rayleigh number in layers with two rigid horizontal boundaries and layers with a free surface is experimentally investigated depending on the Rayleigh and Marangoni numbers.

The experiments were carried out with layers of ethyl alcohol and water. A thermal imager was used to measure temperature fields on free surfaces of liquids.
This article examines evidence for elevations in basal metabolic rate (BMR) among indigenous Northern (circumpolar) populations and considers potential mechanisms and the adaptive basis for such elevations. Data on BMR among indigenous (n = 109 males; 122 females) and nonindigenous (n = 15 males; 22 females) circumpolar groups of North America and Siberia are compiled and compared to predicted BMRs based on three different references: body surface area (Consolazio et al., 1963), body mass (Schofield, 1985), and fat-free mass (Poehlman and Toth, 1995). Regardless of which reference is used, indigenous circumpolar groups show systematic and statistically significant elevations in BMR ranging from +7% to +19% above predicted values for indigenous men and from +3 to +17% for indigenous women. Nonindigenous males also show elevations in BMR, although not to the same extent as in indigenous men (deviations = +3 to +14%), whereas nonindigenous females show no clear evidence of elevated BMRs (deviations = -7 to +5%). This pattern of variation between indigenous and nonindigenous groups suggests that both functional and genetic factors play a role in metabolic adaptation to northern climes. Recent studies on the ecology and genetics of thyroid function offer insights into the mechanisms through which indigenous circumpolar populations may regulate metabolic rates. Studies of seasonal variation in thyroid hormone levels suggest that indigenous circumpolar populations may have a greater capacity to elevate BMR during severe cold than nonindigenous groups. Recent twin studies indicate a significant genetic component of thyroid responses to environmental stressors. Further research exploring the genetics of seasonal variation in thyroid function and BMR among circumpolar groups would advance understanding of the role that selection may have played in shaping metabolic variation.
One of the most widespread prokaryotic symbionts of invertebrates is the intracellular bacteria of Wolbachia genus which can be found in about 50% of insect species. Wolbachia causes both parasitic and mutualistic effects on its host that include manipulating the host reproductive systems in order to increase their transmission through the female germline, and increasing the host fitness. One of the mechanisms, promoting adaptation in biological organisms, is a non-specific neuroendocrine stress reaction. In insects, this reaction includes catecholamines, dopamine, serotonin and octopamine, which act as neurotransmitters, neuromodulators and neurohormones. The level of dopamine metabolism correlates with heat stress resistance in Drosophila adults. To examine Wolbachia effect on Drosophila survival under heat stress and dopamine metabolism we used five strains carrying the nuclear background of interbred Bi90 strain and cytoplasmic backgrounds with different genotype variants of Wolbachia (produced by 20 backcrosses of Bi90 males with appropriate source of Wolbachia). Non-infected Bi90 strain (treated with tetracycline for 3 generations) was used as a control group. We demonstrated that two of five investigated Wolbachia variants promote changes in Drosophila heat stress resistance and activity of enzymes that produce and degrade dopamine, alkaline phosphatase and dopamine-dependent arylalkylamine N-acetyltransferase. What is especially interesting, wMelCS genotype of Wolbachia increases stress resistance and the intensity of dopamine metabolism, whereas wMelPop strain decreases them. wMel, wMel2 and wMel4 genotypes of Wolbachia do not show any effect on the survival under heat stress or dopamine metabolism. L-DOPA treatment, known to increase the dopamine content in Drosophila, levels the difference in survival under heat stress between all studied groups. The genotype of symbiont determines the effect that the symbiont has on the stress resistance of the host insect.
B chromosomes (Bs) represent a variable addition to the main karyotype in some lineages of animals and plants. Bs accumulate through non-Mendelian inheritance and become widespread in populations. Despite the presence of multiple genes, most Bs lack specific phenotypic effects, although their influence on host genome epigenetic status and gene expression are recorded. Previously, using sequencing of isolated Bs of ruminants and rodents, we demonstrated that Bs originate as segmental duplications of specific genomic regions, and subsequently experience pseudogenization and repeat accumulation.

Here, we used a similar approach to characterize Bs of the red fox (Vulpes vulpes L.) and the Chinese raccoon dog (Nyctereutes procyonoides procyonoides Gray). We confirm the previous findings of the KIT gene on Bs of both species, but demostrate an independent origin of Bs in these species, with two reused regions.

Comparison of gene ensembles in Bs of canids, ruminants, and rodents once again indicates enrichment with cell-cycle genes, development-related genes, and genes functioning in the neuron synapse. The presence of B-chromosomal copies of genes involved in cell-cycle regulation and tissue differentiation may indicate importance of these genes for B chromosome establishment.
A popular version of the finite strain Maxwell fluid is considered, which is based on the multiplicative decomposition of the deformation gradient tensor. The model combines Newtonian viscosity with hyperelasticity of Mooney-Rivlin type; it is a special case of the viscoplasticty model proposed by Simo and Miehe (1992). A simple, efficient and robust implicit time stepping procedure is suggested. Lagrangian and Eulerian versions of the algorithm are available, with equivalent properties. The numerical scheme is iteration free, unconditionally stable and first order accurate. It exactly preserves the inelastic incompressibility, symmetry, positive definiteness of the internal variables, and w-invariance. The accuracy of the stress computations is tested using a series of numerical simulations involving a non-proportional loading and large strain increments. In terms of accuracy, the proposed algorithm is equivalent to the modified Euler backward method with exact inelastic incompressibility; the proposed method is also equivalent to the classical integration method based on exponential mapping. Since the new method is iteration free, it is more robust and computationally efficient. The algorithm is implemented into MSC.MARC and a series of initial boundary value problems is solved in order to demonstrate the usability of the numerical procedures.