Hengzongshu/ArticleAgent huggingface dataset:
Modern industry and science require novel 3D optical measuring systems and laser technologies with micro/nanometer resolution for solving actual problems. Such systems, including the 3D dimensional inspection of ceramic parts for electrotechnical industry, laser inspection of wheel pair diagnostic for running trains and 3D superresolution low-coherent micro- /nanoprofilometers are presented.

The newest results in the field of laser technologies for high-precision synthesis of microstructures by updated image generator using the semiconductor laser are given.

The measuring systems and the laser image generator developed and produced by TDI SIE and IAE SB RAS have been tested by customers and used in different branches of industry and science.
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants.

To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes.

Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach.
The authors continue to use hardware acceleration to calculate tsunami wave propagation in a few seconds at modern PC. The goal of this work is to develop original implementation the FPGA-based algorithm for nested-grids computations of tsunami wave propagation. The FPGA-based Calculator, for regular grid has been proposed and numerically tested earlier. Use of the nested grid approach makes it possible to calculate wave propagation almost until the shore line. Numerical tests are based on the real digital bathymetry at southern part of Japan. Mesh step variation of the gird is from 180 m to just 7 m. Realistic shape of the initial sea surface displacement at tsunami source was used. The detailed distribution of wave height maxima around and inside the Onahama port have been issued as a result of tsunami generated by a model source located along the Japan deep-water trench. The superfast FPGA calculator provides an opportunity to obtain the calculated wave parameters inside ports and harbours even before arrival of tsunami wave.
The axially symmetric mirror trap with deuterium-tritium plasma is considered as a neutron source for the hybrid reactor.

The procedure is proposed for verifying the sufficient criterion for stability of the drift-cone ion-cyclotron mode.

Within a limited set of configurations under consideration, the maximum fusion reaction power of 5.8 MW is achieved at an input power of 100 MW.
Spin relaxation was studied in a two-dimensional electron gas confined in a wide GaAs quantum well. Recently, the control of the spin relaxation anisotropy by diffusive motion was first shown in D. Iizasa et al., arXiv:2006.08253 (2020). Here, we demonstrate electrical control by drift transport in a system with two-subbands occupied. The combined effect of in-plane and gate voltages was investigated using time-resolved Kerr rotation. The measured relaxation time present strong anisotropy with respect to the transport direction. For an in-plane accelerating electric field along $\left[110\right]$, the lifetime was strongly suppressed irrespective of the applied gate voltage. Remarkably, for transport along $\left[1\bar{1}0\right]$, the data shows spin lifetime that was gate-dependent and longer than in the $\left[110\right]$ direction regardless of the in-plane voltage. In agreement, independent results of anisotropic spin precession frequencies are also presented. Nevertheless, the long spin lifetime, strong anisotropy and drift response seen in the data are beyond the existing models for spin drift and diffusion.
The drift-flux model is used as gas-liquid mixture equations. The velocities of both phases, mixture and gas, are related by the Zuber-Findlay equation which coefficients depend on flow regime and gas void fraction.

Lagrangian coordinates are used to simplify the initial equations. The numerical solution scheme is proposed. The numerical solution of the Riemann problem is verified by comparison with the exact self-similar solution.

The model and numerical method efficiency is illustrated by examples of gas kick calculations in a vertical well.
The article examines the case of integration of an intellectually gifted adolescent with autism spectrum disorder in a general education school. The child, diagnosed with Asperger's syndrome at early school age, encountered difficulties related to the inability to study effectively at school in spite of the clear evidence of intellectual giftedness.

It provides results of the applied behavioral analysis aimed at developing general learning skills. The article reflects on the risks and advantages of the developmental work with the 'twice exceptional' adolescent following an individual behavioral plan.

Based on the results of the study, the article outlines the possible ways of forming the learning behavior skills: learning activity-based, communicative and organizational. The article discusses the necessity of further support of the 'twice exceptional' adolescent based on an integrated approach with regard to the special learning needs of the intellectually gifted adolescent.
First in the Au-Te-Se-S system (where Te ≥ Se + S) quadruple chalcogenides were obtained by dry synthesis: AuX (AuTe0,7Se0,2S0,1), Au3X10 (Au3Te6Se3S, Au3Te6Se2,5S1,5) и AuX2 (AuTe1,8Se0,2, AuTe1,8Se0,1S0,1). According to the results of X-ray phase analysis, the synthetic phases of the composition AuTe1,8(Se,S)0,2 correspond to the calaverite (AuTe2).

The unidentified peaks on the diffractograms belong to the new gold chalcogenides AuTe0,7Se0,2S0,1 and Au3Te6(Se,S)4. Obviously, they are synthetic analogues of compounds previously unknown in nature, found on the Gatching occurence of the Maleteuyamsky ore field (Central Kamchatka volcanic belt). The compositions of natural phases cover the intervals: 1) Au0,99-1,00Te0,70-0,71Se0,25-0,27S0,03-0,06; 2) Au2,91-3,08Te5,85-6,06Se1,57-3,66S2,63-0,44.

Raman spectra of synthetic and natural gold chalcogenides with a similar composition have identical character.
We are concerned with a hydrodynamical model of layered structures at the presence of the electric current.

We formulate a linearized stability problem for shock waves

and prove its ill-posedness, which means instability of shock waves for the given model of layered structures.
There has recently been great interest in the cryogels based on polyvinyl alcohol. Cryogel usage allows improving existing materials and creating new ones. Cryogel is completely safe, both for humans and for the soil. It protects the soil from drying out and erosion and enhances plant growth, making them more adaptive to the environment. Under the conditions of the Far North, cryogels might be used to strengthen building structures in order to prevent destruction. There is a question of monitoring cryogel distribution in the treated environment. To do this, one needs to know the physical properties of cryogel and composites with ground on its basis. This work aims to study the electrical properties and pore space structure of the composites made from ground and cryogel at various temperatures and various amounts of freezing cycles.
Characteristics and catalytic activity in hydrogen production from formic acid of Au catalysts supported on porous N-free (Au/C) and N-doped carbon (Au/N-C) have been compared with those of Au/SiO2 and Au/Al2O3 catalysts.

According to XPS data the Au was present in metallic state in all catalysts after the reaction. TEM analysis revealed that the use of the N-C support allowed obtaining highly dispersed Au nanoparticles with a mean size of about 2 nm, which was close to those for the Au catalysts on the oxide supports. This was confirmed by density functional theory (DFT) calculations.

Among the catalysts examined, the Au/N-C catalyst showed the highest Au mass-based catalytic activity. The following trend was found at 448 K: Au/N-C > Au/SiO2 > Au/Al2O3, Au/C. The trend for the selectivity in hydrogen production was different: Au/C (99.5%) > Au/Al2O3 (98.0%) > Au/N-C (96.3%) > Au/SiO2 (83.0%). However, it was by a factor of 5 smaller than that for the Au/C catalyst. The difference in dispersion could explain the difference in the catalytic activity for the carbon-based catalysts. Additionally, the high activity of the Au/N-C catalyst could be related to the presence of pyridinic type nitrogen on the N-doped carbon surface, which activates the formic acid molecule forming pyridinium formate species further interacting with Au. The results of this study may assist the development of novel Au catalysts for different catalytic reactions.
The mounting challenge of preserving the quality of life in an aging population directs the focus of longevity science to the regulatory pathways controlling healthspan.

To understand the nature of the relationship between the healthspan and lifespan and uncover the genetic architecture of the two phenotypes, we studied the incidence of major age-related diseases in the UK Biobank (UKB) cohort. We observed that the incidence rates of major chronic diseases increase exponentially. The risk of disease acquisition doubled approximately every eight years, i.e., at a rate compatible with the doubling time of the Gompertz mortality law. Assuming that aging is the single underlying factor behind the morbidity rates dynamics, we built a proportional hazards model to predict the risks of the diseases and therefore the age corresponding to the end of healthspan of an individual depending on their age, gender, and the genetic background. We suggested a computationally efficient procedure for the determination of the effect size and statistical significance of individual gene variants associations with healthspan in a form suitable for a Genome-Wide Association Studies (GWAS). Using the UKB sub-population of 300,447 genetically Caucasian, British individuals as a discovery cohort.

We identified 12 loci associated with healthspan and reaching the whole-genome level of significance. We observed strong (| ρ g | > 0.3) genetic correlations between healthspan and the incidence of specific age-related disease present in our healthspan definition (with the notable exception of dementia). Other examples included all-cause mortality (as derived from parental survival, with ρ g = −0.76), life-history traits (metrics of obesity, age at first birth), levels of different metabolites (lipids, amino acids, glycemic traits), and psychological traits (smoking behaviour, cognitive performance, depressive symptoms, insomnia). We conclude by noting that the healthspan phenotype, suggested and characterized here, offers a promising new way to investigate human longevity by exploiting the data from genetic and clinical data on living individuals.
Exosomes represent a sort of extracellular vesicles, which transfer molecular signals in organism and possess markers of producing cells. Our study was aimed at search of exosomes in the tears of healthy humans, confirmation of their nature and examination of exosome morphological and molecular-biological characteristics. The tears (110-340 ml) were collected from 24 healthy donors (aged 46-60 years); individual probes were centrifuged at 20000 g for 15 min to pellet cell debris. The supernatants were examined in electron microscope using negative staining; and they were also used for isolation and purification of the exosomes by filtration (100 nm pore-size) and double ultracentrifugation (90 min at 100000 g, 4°C). The “pellets” were subjected to electron microscopy, immunolabeling. The RNA and DNA were isolated from the samples, and their sizes were evaluated by capillary electrophoresis, the concentration and localization of nucleic acids were determined. Sequencing of DNA was performed using MiSeq (“Illumina”, USA), data were analyzed using CLC GW 7.5 (“Qiagen”, USA). Sequences were mapped on human genome (hg19). Electron microscopy revealed in supernatants of the tears cell debris, spherical microparticles (20-40 nm), membrane vesicles and macromolecular aggregates. The “pellets” obtained after ultracentrifugation, contained microparticles (17%), spherical and cup-shaped EVs (40-100 nm, 83%), which were positive for CD63, CD9 and CD24 receptors (specific markers of exosomes). Our study showed presence of high amount of exosomes in human tears, and relation of the exosomes with RNA (size less than 200 nt) and DNA (size was 3-9 kb). Sequencing of the DNA showed that about 92% of the reads mapped to human genome.
We propose a new model, entitled S-CTC, for description of quantum systems in the presence of CTC – closed time-like curves. The model is based on the viewpoint on any quantum state as an observer’s state of knowledge of the system preparation procedure. We compare and contrast our S-CTC model with D-CTC and P-CTC models and show that S-CTC shares special quantum features with both D-CTC and P-CTC. As far as the interaction of the quantum system with itself coming from the future concerns, S-CTC is formally equivalent to P-CTC. On the other hand, when calculating outcome probabilities for a measurement within the time interval between the entrance and exit of CTC, S-CTC becomes equivalent to D-CTC. Both these models require the concept of alternative realities (worlds) where different measurement outcomes are recorded and alternative connections of these realities by CTC.
The purpose of the study is to identify and analyze patterns of the diurnal dynamics of the expression of genes that diﬀer in the shape of the curve. It can be expected that the similarity of the patterns of daily expression (shape of the curve) of genes is a reﬂection of the synchronization of gene expression by common external and internal signals or participation in similar biological processes. Diﬀerent signals that have daily dynamics (light, activity, nutrition, stress, temperature, etc.) can aﬀect diﬀerent levels of expression regulation, which can be manifested in various forms of patterns of daily gene expression. In our research, we used experimental data on gene expression at the level of translation (ribosome profling) in the liver and kidney of a mouse (GSE67305 and GSE81283). To identify genes with a daily rhythm of expression, we used a oneway analysis of variance. To identify similar­in­shape curves of the daily dynamics of gene expression, we propose an approach based on cluster analysis. The distance between the genes was calculated by aligning the phases and fnding the maximum cross­correlation between the patterns of the daily expression of these genes by the cyclic shift. This approach allowed us to identify genes that have not only expression patterns with a single maximum (sinusoidal, asymmetrical, shifted to the left or right, pulsed), but also complex composite signals with several extremes. As a result, the groups of genes united by the similarity of the shape of the daily expression curve without regard to their phase characteristics were identifed. GO enrichment analysis of groups of genes with sharply different patterns of daily expression (sinusoidal and pulsed) in the mouse kidneys and liver showed that the group of genes with a sinusoidal pattern was more associated with regulation of circadian rhythm and metabolism. The group of genes with a pulsed pattern is largely associated with the protective functions of the organism, which require the quick response. Thus, our studies have confrmed the eﬀectiveness of the proposed approach to the analysis of the diurnal dynamics of gene expression. The identifed dynamic patterns of diurnal expression are important for the further study of complex circadian regulation, synchronization and interaction of biological processes with diurnal dynamics in mammals.
Aim. To study serum levels of Klotho protein in men with arterial hypertension and to explore its association with some cardiometabolic risk factors.

Methods . 134 men with hypertension aged 50-65 years old and over 80 years old were enrolled in a study. 44 men of the corresponding age without high blood pressure were enrolled in the control group. Serum levels of Klotho protein were measured using ELISA.

Results. Both, the study and the control group, have similar serum levels of Klotho protein (464 [287; 849] and 458 [128; 1121] pg/dL, respectively; p>0.05). Significant differences in the serum levels of Klotho protein in the study groups are related to three risk factors: physical inactivity, obesity, and the presence of diabetes mellitus. A positive correlation between Klotho protein levels and regular physical activity has been found in men with arterial hypertension. Besides, negative correlations between Klotho proteins and diabetes mellitus and obesity have been stated. Multivariate analysis reports a positive association between Klotho protein and regular physical activity in men with hypertension regardless of their age, diabetes, lipid disorders, and obesity. Conclusion . Men with arterial hypertension and without it have similar Klotho protein levels. Serum Klotho protein levels are lower in obese men who are physically inactive. Klotho protein levels are lower in men with hypertension and concomitant diabetes mellitus. Klotho protein is positively associated with regular physical activity regardless of age and some cardiometabolic risk factors in men with arterial hypertension.
Objectives of the TAIGA Astrophysical complex include the study of the flux of charged cosmic rays and diffuse gamma rays with energies above 100 TeV. This complex is located in the Tunka Valley about 50 km from Lake Baikal at the site of the Tunka-133 Cherenkov facility.

TAIGA includes the TAIGA-HiSCORE wide-angle Cherenkov array, the network of Imaging Atmospheric Cherenkov Telescopes (TAIGA-IACT), the Tunka-Grande and TAIGA-Muon scintillation arrays. In this work, we present the results of an analysis of the joint events of the Tunka-Grande scintillation array and TAIGA-HiSCORE and Tunka-133 Cherenkov facilities.

The results verify sufficient accuracy of the scintillation experiment for the hybrid study of mass composition of cosmic rays and gamma-hadron separation.
Used the set-up with a semi-circular gap allows the realization of different types of Couette flow and to change the flow parameters (velocity, pressure, Reynolds and Knudsen numbers, etc.) over a wide range. Reynolds number can be varied by the cylinder rotation speed and pressure inside the facility. Obtaining high Knudsen numbers is possible at low pressures and using light gases, since the system is sealed. The nature of the flow varies from laminar to turbulent ones. Simulation of the properties of the flat Couette flow in the stand should be ensured by minimizing the influence on the flow of centrifugal forces, which are manifested by distortion of the linear velocity profile. Preliminary experiments have shown the possibility of modeling the formation of longitudinal vortices in a semi-circular channel similar to the circular Couette flow.
Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical practice, applications of existing diagnostic solutions based on the detection of somatic mutations or analysis of gene expression are limited by their high cost and difficulties with clinical interpretation. The aim of our work was to develop an algorithm for the differential diagnosis of thyroid nodules on the basis of a small set of molecular markers analyzed by real-time PCR.A total of 494 preoperative FNA samples of thyroid goiters and tumors from 232 patients with known histological reports were analyzed: goiter, 105 samples (50 patients); follicular adenoma, 101 (48); follicular carcinoma, 43 (28); Hürthle cell carcinoma, 25 (11); papillary carcinoma, 121 (56); follicular variant of papillary carcinoma, 80 (32); and medullary carcinoma, 19 (12). Total nucleic acids extracted from dried FNA smears were analyzed for five somatic point mutations and two translocations typical of thyroid tumors as well as for relative concentrations of HMGA2 mRNA and 13 microRNAs and the ratio of mitochondrial to nuclear DNA by real-time PCR. A decision tree-based algorithm was built to discriminate benign and malignant tumors and to type the thyroid cancer. Leave-p-out cross-validation with five partitions was performed to estimate prediction quality. A comparison of two independent samples by quantitative traits was carried out via the Mann-Whitney U test.A minimum set of markers was selected (levels of HMGA2 mRNA and miR-375, - 221, and -146b in combination with the mitochondrial-to-nuclear DNA ratio) and yielded highly accurate discrimination (sensitivity = 0.97; positive predictive value = 0.98) between goiters with benign tumors and malignant tumors and accurate typing of papillary, medullary, and Hürthle cell carcinomas. The results support an alternative classification of follicular tumors, which differs from the histological one.The study shows the feasibility of the preoperative differential diagnosis of thyroid nodules using a panel of several molecular markers by a simple PCR-based method. Combining markers of different types increases the accuracy of classification.
Background Social cohesion has a potential protective effect against depression, but evidence for Central and Eastern Europe is lacking.

Methods Cohort data from 15 438 older urban participants from the Health, Alcohol and Psychosocial factors In Eastern Europe project were analysed. Baseline social cohesion was measured by five questions, and depressive symptoms were measured 3 years later by the 10-item Center for Epidemiological Depression (CES-D) Scale. Nested logistic regression models estimated ORs of elevated depressive symptoms (CES-D 10 score ≥4) by z-scores and tertiles of social cohesion.

Results Per 1 SD decrease in social cohesion score, adjusted ORs of elevated depressive symptoms were 1.13 (95% CI 1.05 to 1.23) and 1.05 (95% CI 0.99 to 1.13) in men and women, respectively. Further adjustment for smoking and drinking did not attenuate these associations in either men (OR=1.13, 95% CI 1.05 to 1.22) or women (OR=1.05, 95% CI 0.99 to 1.13). Similarly, the fully adjusted ORs comparing the lowest versus highest social cohesion tertile were 1.33 (95% CI 1.10 to 1.62) in men and 1.18 (95% CI 1.01 to 1.39) in women. Conclusions Lower levels of social cohesion was associated with heightened depressive symptoms after a 3-year follow-up among older Czech, Russian and Polish adults. These effects appeared stronger in men, and alcohol and smoking played no appreciable role in this association.