Hengzongshu/ArticleAgent huggingface dataset:
Cloud computing and, more particularly, cloud databases, is a great technology for remote centralized data managing.However, there are some drawbacks including privacy issues, insider threats and potential database thefts.Full encryption of remote database does solve the problem, but disables many operations that can be held on DBMS side; therefore problem requires much more complex solution and specific encryptions.

In this paper, we propose a solution for secure private data storage that protects confidentiality of user's data, stored in cloud.Solution uses order preserving and homomorphic proprietary developed encryptions.Proposed approach includes analysis of user's SQL queries, encryption of vulnerable data and decryption of data selection, returned from DBMS.

We have validated our approach through the implementation of SQL queries and DBMS replies processor, which will be discussed in this paper.
Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications. Despite the fact that there is a large group of antihypertensive drugs on the market, mainly representing different combinations of inhibitors of the renin-angiotensin system, adrenoreceptor blockers in combination with diuretics, there is no generally accepted “gold standard” for drugs that would not have side effects.

The review discusses the main aspects of antisense oligonucleotides use in the context of arterial hypertension. It is well known that the medical implementation of antisense oligonucleotides aims to block the expression of particular genes involved in the pathology development, and a key advantage of this technique is a high selectivity of the effect. However, with the undoubted advantages of the method, there are difficulties in its application, related both to the properties of the oligonucleotides themselves (insufficient stability and poor penetration into cells), and to the variety of mechanisms of the origin of a particular pathology, arterial hypertension, in our case. The review provides a brief description of the main molecular targets for antisense treatment of hypertensive disease. The newest targets for therapy with oligonucleotides – microRNAs – are discussed. The main modifications of antisense nucleotides, designed to increase the duration of their effects and simplify the delivery of this type of drugs to the targets are discussed, in particular, combining antisense oligonucleotides with adenovirus-based expression vectors. Particular attention is given to antisense oligonucleotides in the complex with nanoparticles. The review discusses the results of the use of titanium dioxide (TiO2) containing antisense nanocomposites for the angiotensin converting enzyme in rats with stress induced arterial hypertension (ISIAH).

It was shown that the use of antisense oligonucleotides continues to be a promising technique for studying the mechanisms of various forms of hypertensive disease and has a high potential for therapeutic use.
We propose a method of constructing analytical, closed-form expressions for electrostatic/Newtonian potentials of non-uniform polyhedral bodies, in which the density distributions are polynomials of coordinates. Possible applications of the proposed method are spread from astronomy to nanotechnology. The method is based on the use of the generating function for the potential. Explicit expressions for the potential are derived in the case of quadratic or cubic coordinate dependence of the density within a polyhedral body.
Charge asymmetry in processes e+ e- --> mu+ mu- gamma and e+ e- --> pi+ pi- gamma is measured using 232 fb-1 of data collected with the BABAR detector at center-of-mass energies near 10.58 GeV. An observable is introduced and shown to be very robust against detector asymmetries while keeping a large sensitivity to the physical charge asymmetry that results from the interference between initial and final state radiation. The asymmetry is determined as afunction of the invariant mass of the final-state tracks from production threshold to a few GeV/c2. It is compared to the expectation from QED for e+ e- --> mu+ mu- gamma and from theoretical models for e+ e- --> pi+ pi- gamma. A clear interference pattern is observed in e+ e- --> pi+ pi- gamma, particularly in the vicinity of the f_2(1270) resonance. The inferred rate of lowest order FSR production is consistent with the QED expectation for e+ e- --> mu+ mu- gamma, and is negligibly small for e+ e- --> pi+ pi- gamma.
We perform a series of URANS simulations of the flow over a rotary oscillating cylinder at Re = 1.4 × 105 to study the possible reduction of the drag and lift forces acting on the body when the rigid wall is rotary oscillating around the axis of symmetry.

Two parameters of the external forcing are varied, i.e. the amplitude of rotation and the frequency.

We find that the high-frequency and relatively high-amplitude forcing leads to the drag reduction of 78% compared to the non-rotating case. The oscillations (rms) of drag and lift coefficients are also significantly reduced.
Aim . To identify associations of polyphenolic compounds consumption in general, as well as their particular classes with the risk of arterial hypertension (AH) in the population of Novosibirsk residents of the 45-69 age group.

Material and methods . In 2003-2005, an epidemiological survey of the population of 45-69 years of Novosibirsk was conducted (HAPIEE international project "Determinants of cardiovascular diseases in Eastern Europe: a multicenter cohort study"). 9360 people were examined, including 4266 men and 5094 women. The average age of the surveyed was 576 years A nutrition assessment was performed using Food Frequency Questionnaire (FFQ) questionnaire. The European base Phenol-Explorer 3,6 was used to estimate the content of polyphenolic compounds and their subclasses. In the structure of each product group, food habits of the Siberian population, typically used products were taken into account. AH was diagnosed in case of systolic blood pressure (SBP) levels >140 mm Hg. and/or diastolic blood pressure (DBP) >90 mm Hg, as well as in individuals with normal blood pressure values while taking antihypertensive drugs in the last two weeks prior to this survey.

Results . The risk of AH developing in the quartile with the highest total consumption of polyphenolic compounds in men is 33% less than in the quartile with the lowest consumption (odds ratio (OR) 0,67 confidence interval (CI) 0,56-0,79, P=0.004), and in women, respectively, — 37% less ( OR 0,63, CI 0,54-0,74, P<0,001). For certain classes of polyphenolic compounds: the highest level of consumption of flavonoids associates with a reduction of AH risk in men by 33% (OR 0,67 CI 0,57-0,80, P<0,001) and in women — by 39% (OR 0,61, CI 0,57-0,71, P=0,002). For both men and women, the probability of AH developing in the quartile with consumption of phenolic acids is 21% lower (OR 0,79, CI 0,66-0,94, P=0,002) and 16% (OR 0,84, CI 0,72-0,99, P<0,001), respectively. In men, the consumption of other polyphenols is also significant (the risk with maximum use is reduced by 18%, OR 0,84, CI 0,69-0,98, P=0,018). Conclusion . In the population of Novosibirsk (age group 45-69 years), high levels of consumption of polyphenols in general, as well as such subclasses as flavonoids and phenolic acids, are associated with a decrease of AH risk.
We can observe self‐organization properties in various systems. However, modern networked dynamical sociotechnical systems have some features that allow for realizing the benefits of self‐organization in a wide range of systems in economic and social areas.

The review examines the general principles of self‐organized systems, as well as the features of the implementation of self‐organization in sociotechnical systems. We also delve into the production systems, in which the technical component is decisive, and social networks, in which the social component dominates; we analyze models used for modeling self‐organizing networked dynamical systems.

It is shown that discrete models prevail at the micro level. Furthermore, the review deals with the features of using continuous models for modeling at the macro level.
The paper is devoted to an experimental and theoretical study of effect of moderate angle-of-attack variation on disturbances evolution and laminar-turbulent transition in a supersonic boundary layer on swept wing at Mach 2.

For the same conditions, calculations based on linear stability theory are performed.

Monotonous growth of the transition Reynolds numbers with angle of attack increasing from −2° to 2.7° is confirmed. The experimental and computational results show a favourable comparison.
The vortex rope in a hydro turbine draft tube is one the main and strong sources of pulsations in non-optimal modes of hydro turbine operation. We examine the case of a Francis turbine model operated at partial discharge, where a strong precessing vortex rope is developed in the discharge cone downstream the runner. Available experimental data provide the circumferentially averaged axial and circumferential velocity profiles, as well as the vortex rope geometry, precessing frequency, and the level of pressure fluctuation at the wall. The mathematical models presented in this paper can correctly recover all this information without actually computing the full three-dimensional unsteady flow in the hydraulic turbine. As a result, we provide valuable mathematical tools for assessing the turbine behaviour at off-design operating regimes in the early stages of runner design, with computational effort several orders of magnitude less than the current approaches of simulating the complex turbine flow.
We measured ordinary and extraordinary refractive index and absorption of ferroelectric lead germanate in the range of 0.1—1.3 THz by the method of terahertz time- domain spectroscopy. We studied soft mode behaviour with the rise of temperature by fitting imaginary part of the complex dielectric permittivity with three Lorentz oscillators. We found that high birefringence and dichroism of lead germanate or its analogues can be used for manufacturing of effective terahertz polarizing filters.
When a metal plate is subjected to a strong shock impact, its free surface emits a flow of particles of different sizes (shock-wave 'dusting'). Traditionally, the process of dusting is investigated by the methods of pulsed x-ray or piezoelectric sensor or via an optical technique. The particle size ranges from a few microns to hundreds of microns. The flow is assumed to include also finer particles, which cannot be detected with the existing methods yet.

On the accelerator complex VEPP-3-VEPP-4 at the BINP there are two experiment stations for research on fast processes, including explosion ones. The stations enable measurement of both passed radiation (absorption) and small-angle x-ray scattering on synchrotron radiation (SR). Radiation is detected with a precision high-speed detector DIMEX. The detector has an internal memory of 32 frames, which enables recording of the dynamics of the process (shooting of movies) with intervals of 250 ns to 2 μs. Flows of nano- and microparticles from free surfaces of various materials (copper and tin) have been examined. Microparticle flows were emitted from grooves of 50-200 μs in size and joints (gaps) between metal parts. With the soft x-ray spectrum of SR one can explore the dynamics of a single microjet of micron size.

The dynamics of density distribution along micro jets were determined. Under a shock wave (∼ 60 GPa) acting on tin disks, flows of microparticles from a smooth surface were recorded.
This work describes the module of the RiskPanel software system, performing risk analysis of multi-step computer attacks. The module is based on statistical analysis of actual computer attack precedents. At the user's request the system calculates objective probability of information security risks, taking into account all possible multi-step attacks (i.e. possible combinations of known attacks). The estimation of probability is presented as an interval because we don't always have a full description of real attacks. The task of this work is described using the model-theoretic formalism. The first step is to build a knowledge base of computer attacks. The formal description of the knowledge base structure is made with the Description Logic. Formalization of estimated (fuzzy) judgments is made in the language of the Fuzzy Model Theory. The article contains algorithms for calculation of probabilistic risk intervals and describes program implementation of the developed methods.
A collection of introgression lines was obtained from crosses of common wheat (Triticum aestivum L.) cultivars with tetraploid wheat Triticum timopheevii (Zhuk.).

Evaluation of resistance to fungal diseases revealed the lines with resistance to leaf and stem rusts, powdery mildew, spot blotch, and loose smut, the most widespread in Siberian region of Russia. Localization of the T. timopheevii genome fragments by means of microsatellite markers determined higher frequency of substitutions and translocations on chromosomes 1А, 2A, 2B, 5A, 5B and 6B. Molecular mapping of the loci determining leaf rust resistance revealed two independent loci on chromosomes 5B and 2A.

The major locus on 5BS.5BL-5GL translocated chromosome accounting 64% of the phenotypic variance of the trait was found to be closely linked to microsatellite markers Xgwm814 and Xgwm1257. The other, minor locus, controlling 11% of the trait was mapped next to Xgwm312 on chromosome 2A. Microsatellite markers located near these genes may be used for controlling the transfer of valuable traits in new wheat cultivars.
Genome-wide association studies have provided a vast array of publicly available SNP × phenotype association results. However, they are often in disparate repositories and formats, making downstream analyses difficult and time consuming. PheLiGe (https://phelige.com) is a database that provides easy access to such results via a web interface. The underlying database currently stores >75 billion genotype-phenotype associations from 7347 genome-wide and 1.2 million region-wide (e.g. cis-eQTL) association scans. The web interface allows for investigation of regional genotype-phenotype associations across many phenotypes, giving insights into the biological function affected by the variant in question. Furthermore, PheLiGe can compare regional patterns of association between different traits. This analysis can ascertain whether a co-association is due to pleiotropy or linkage. Moreover, comparison of association patterns for a complex trait of interest and gene expression and protein levels can implicate causal genes.
Despite longstanding applications of microbial proteases and a large number of research papers, the search for new protease genes, the construction of producer strains, and the development of methods for their practical application are still relevant and important, judging by the number of citations of the research articles on proteases and their microbial producers. This enzyme class represents the largest share of the industrial production of proteins worldwide.

The review covers subtilisin classification, the history of their discovery, and subsequent research on the optimization of their properties. An overview of the classes of subtilisin proteases and related enzymes is provided too. There is a discussion about the problems with the search for (and selection of) subtilases from natural strains of various microorganisms, approaches to (and specifics of) their modification, as well as the relevant genetic engineering techniques. Details are provided on the methods for expression optimization of industrial subtilases of various strains: the details of the most important parameters of cultivation, i.e., composition of the media, culture duration, and the influence of temperature and pH. Also presented are the results of the latest studies on cultivation techniques: submerged and solid-state fermentation.

From the literature data reviewed, we can conclude that native enzymes (i.e., those obtained from natural sources) currently hardly have any practical applications because of the decisive advantages of the enzymes modified by genetic engineering and having better properties. The vast majority of subtilisin proteases are expressed in producer strains belonging to different species of the genus Bacillus. Meanwhile, there is an effort to adapt the expression of these enzymes to other microbes, in particular species of the yeast Pichia pastoris.
A commented translation into Russian of Empedocles’ fragment B17 with the addition of several new lines available in the Strasbourg papyrus (on the basis of the so called Ensemble c). This badly fragmented piece of evidence is translated into Russian for the first time.
Objective. To study in cross-sectional research the association of actual nutrition with estimates of cognitive function (CF) in the population of men and women of middle and older age (45–69 years). Materials and methods . The study was conducted in the framework of the international project HAPIEE on a random subsample (2,159 men, 2,525 women) of residents of Novosibirsk. Evaluation of CF was carried out using standard methods (test for direct reproduction of 10 words, test for speech activity (associative thinking) and test for delayed reproduction). Nutrition data was obtained from population surveys in the HAPIEE project using a questionnaire to assess the frequency of food consumption. Statistical data processing was performed using the SPSS 13.0 application package. The GLM procedure was used, allowing to take into account the influence of related factors. Differences were considered statistically significant at p < 0.05. Results . The presence of a significant correlation between the actual nutrition with standardization by age, body mass index and level of education with CF estimates was found. It has been shown that higher consumption of fruits and vegetables was significantly associated with higher scores in both men and women. Women, unlike men, also showed significantly higher CF estimates for consumption of rice, meat products and dairy products. In addition, there was a negative association of CF with the consumption of a number of products. Men showed a significant decrease in the estimates of CF with the consumption of sugar and fats; in women, in the consumption of white bread, sugar and fat. Conclusion : the results of our study showed the presence of a significant association of CF estimates with the level of consumption of a number of products, both positive and negative, in middle-aged and older people. These data may be useful in the development of nutritional recommendations for the prevention of violations of CF.
In the article the four-level model of the image of the author of publicistic text is considered. There are metatext, its structure and semantics are analyzed. The authors analyze the formation of meanings at the level of actual, conceptual and implicit information. The article proves the connection of metalanguage behavior with the semantic structure of the text. The authors identify the main functions of metatext in the column genre: coherence, differentiation of subject-speech narrative plans, characterization of words and utterances as signals of an epoch or social situation, modeling of the author’s image, etc. “Textotyping” is considered as special function of metatext. The authors also distinguish different types of metatext, including hidden metatext and metatext and fictitious metatext. A sample of metatext analysis of media production is shown. The article analyzes the speech mask and metatext behavior as a component of the author’s image.
Modern high-power lasers exhibit a rich diversity of nonlinear dynamics, often featuring nontrivial co-existence of linear dispersive waves and coherent structures. While the classical Fourier method adequately describes extended dispersive waves, the analysis of time-localised and/or non-stationary signals call for more nuanced approaches. Yet, mathematical methods that can be used for simultaneous characterisation of localized and extended fields are not yet well developed. Here, we demonstrate how the Nonlinear Fourier transform (NFT) based on the Zakharov-Shabat spectral problem can be applied as a signal processing tool for representation and analysis of coherent structures embedded into dispersive radiation. We use full-field, real-time experimental measurements of mode-locked pulses to compute the nonlinear pulse spectra. For the classification of lasing regimes, we present the concept of eigenvalue probability distributions. We present two field normalisation approaches, and show the NFT can yield an effective model of the laser radiation under appropriate signal normalisation conditions.
On generic structures preserving elementary equivalence and elementary embeddabilityWe consider criteria for elementary equivalence and elementary embeddability for generic structures.They use classical characterizations for the general case.The criterion for elementary equivalence is based on the well known Fraïssé-Taimanov-Ehrenfeucht overturning method.The criterion for elementary embeddability uses the known Tarski-Vaught test.
Статья посвящена ускорению параллельного решения трехмерных краевых задач методом декомпозиции расчетной области на подобласти, сопрягаемые без наложения. Декомпозиция проводится равномерной параллелепипедальной макросеткой. В каждой подобласти и на границе сопряжения (интерфейсе) строятся свои структурированные подсетки. Объединение этих подсеток образует квазиструктурированную сетку, на которой решается поставленная задача. Распараллеливание решения осуществляется при помощи MPI-технологий. Предложен и экспериментально исследован алгоритм ускорения внешнего итерационного процесса по подобластям для решения системы линейных алгебраических уравнений, аппроксимирующих уравнение Пуанкаре-Стеклова на интерфейсе. Проведены серии численных экспериментов на различных квазиструктурированных сетках и при различных параметрах вычислительных алгоритмов, показывающих ускорение вычислений. This paper is devoted to the acceleration of the parallel solution of three-dimensional boundary value problems by the computational domain decomposition method into subdomains that are conjugated without overlapping. The decomposition is performed by a uniform parallelepipedal macrogrid. In each subdomain and on the interface, some structured subgrids are constructed. The union of these subgrids forms a quasi-structured grid on which the problem is solved. The parallelization is carried out using the MPI-technology. We propose and experimentally study the acceleration algorithm for an external iterative process on subdomains to solve a system of linear algebraic equations approximating the Poincare-Steklov equation on the interface. A number of numerical experiments are carried out on various quasi-structured grids and with various parameters of computational algorithms showing the acceleration of computations.