Hengzongshu/ArticleAgent huggingface dataset:
In this contribution, a method based on a solid solution theory of clathrate hydrate for multiple cage occupancy, host lattice relaxation, and guest-guest interactions is presented to estimate hydrate formation conditions of binary and ternary gas mixtures.

We performed molecular modeling of the structure, guest distribution, and hydrate formation conditions for the CO₂ + CH₄ and CO₂ + CH₄ + N₂ gas hydrates.

In all considered systems with and without N₂, at high and medium content of CO₂ in the gas phase, we found that CO₂ was more favorable in occupying clathrate hydrate cavities than CH₄ or N₂. The addition of N₂ to the gas phase increased the ratio concentration of CO₂ in comparison with the concentration of CH₄ in clathrate hydrates and made gas replacement more effective. The mole fraction of CO₂ in the CO₂ + CH₄ + N₂ gas hydrate rapidly increased with the growth of its content in the gas phase, and the formation pressure of the CO₂ + CH₄ + N₂ gas hydrate rose in comparison to the formation pressure of the CO₂ + CH₄ gas hydrate. The obtained results agreed with the known experimental data for simple CH₄ and CO₂ gas hydrates and the mixed CO₂ + CH₄ gas hydrate.
We numerically characterise, in the three-dimensional space of adjustable cavity parameters, the performance of a recently reported layout of a flexible figure-8 laser having two independently pumped segments of active fibre in its bidirectional ring (Smirnov et al 2017 Opt. Lett. 42 1732–5).

We show that this optimisation problem can be efficiently addressed by applying a regression model based on a neural-network algorithm.
The vacuum polarization in an external gravitational field due to one loop electron-positron pair and one loop millicharged fermion-antifermion pair is studied. Considering the propagation of electromagnetic (EM) radiation and gravitational waves (GWs) in an expanding universe, it is shown that by taking into account QED effects in curved spacetime, the propagation velocity of photons is superluminal and can exceed that of gravitons. We apply these results to the case of the GW170817 event detected by LIGO. If the EM radiation and GWs are emitted either simultaneously or with a time difference from the same source, it is shown that the EM radiation while propagating with superluminal velocity, would be detected either in advance or in delay with respect to GW depending on the ratio of millicharged fermion relative charge to mass /m.
A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student's t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.
Evaporation of liquid microdroplets that fall on a solid surface with the temperature of below the Leidenfrost temperature is studied.

It has been found out that sufficiently small liquid droplets of about 10 microns can suspend at some distance from the surface (levitate) and do not reach the surface; at that, the rate of droplet evaporation is reduced by an order as compared to microdroplets, which touch the surface.

It is determined that in contrast to microdroplets, which touch the surface, the specific evaporation rate of levitating droplets is constant in time.
We report new paleomagnetic data from the ~1108 Ma intrusive Coldwell Complex (Ontario, Canada) to investigate the apparent reversal asymmetry observed in some Midcontinent Rift (MCR) rocks.

The rocks of eastern and central part of the complex are reversely magnetized with a group mean direction of D = 114.8°, I = −63.7° ( α 95 = 3.6°, N = 30). The corresponding paleomagnetic pole at P lat = 47.2°N, P long = 206.5°E ( A 95 = 4.8°) is located close to the paleomagnetic poles from nearly coeval reversely magnetized rocks of the MCR system, including the lower lava flows at Mamainse Point. The rocks of western part of the complex are normally magnetized with a group mean direction ( D = 298.0°, I = 56.9°, α 95 = 5.8°, N = 10) that passes the reversal test with respect to the reversed group mean direction.

Our results do not support the previous model in which the complex was emplaced during two periods of reversed geomagnetic field polarity separated by a period of normal polarity and hence encompasses two geomagnetic reversals. Instead, our new data indicate that the Coldwell Complex records only two polarity intervals separated by a symmetrical reversal at ~1102–1105 Ma. This reversal is likely equivalent to the lowermost reversal recorded at Mamainse Point and provides further evidence that the apparent reversal asymmetry reflects a plate motion rather than a persistent nondipole field geometry. Together with a high‐quality data from the ~1098 Ma North Shore Volcanics, our data indicate a rapid velocity of Laurentia at ~25 ± 4 cm/yr. The fast plate motion may reflect a decreased mantle drag due to vigorous mantle indicated by widespread intraplate magmatism at ~1.1 Ga.
The dependence of porosity and durability of Al2O3 on various organic additives (ethylene glycol, diethylene glycol, glycerin, industrial oil and their combinations) was shown.

Some of results were used to synthesize 3D-structured catalysts.
In traditional Russian literature, the motif of losing oneself regularly serves as the motivation for spiritual transformation and search for salvation of the character, promoting the plot of a literary text and creating new types of characters. However, it is not difficult to notice the transformation in the utilization and implementation of this motif in the plot composition of postmodern texts based on the principle of uncertainty and randomness, which is opposed to the teleology of the classical narrative. The relevance of the topic is due to the insufficiency of research on such changes, especially in the postmodern works by Viktor Pelevin. Though there have been several observations on Pelevin’s textual structure, the role of motifs in organizing and constructing the plot remains outside the scope of researchers’ attention. This article aims to reveal the role and specifics of the motif “the loss of oneself” as a plot-forming component in the novel Generation “P” by V. O. Pelevin. Based on the contemporary motif theory, it particularly pays attention to the context of allomotifs and events associated with the motifeme of losing oneself, following A. Dundes, who understands the motifeme as the basic unit in the paradigmatics of the narrative, and allomotifs as its syntagmatic variants. Through analyzing various variations of allomotifs “the loss of oneself” (losing the feeling of eternity, symbolic death, metamorphosis, manipulation, etc.), the paper attempts to reveal constructive components of the narrative structure in this novel, which determined its artistic semantics. Arguing the tragic essence of the individual value orientation on consumerism in the context of the eschatological media mythology, it also finds out that Pelevin constructs the plot as Tatarsky’s rising up the career ladder, accompanied by the loss of personality, the replacement of Homo sapiens by Homo Zappiens. To achieve this purpose, he widely uses different schemes that implement the emic motifeme through various variations of allomotifs. That’s why, the success of the protagonist in the ending does not mean the spiritual salvation, but the totality of submission to the God of money and immersion in the void, where the way out of the new social and mental impasse is impossible not only for the protagonist but also for the novelist himself. Keywords: Victor Pelevin, Generation “P”， motifeme of losing oneself, set of allomotifs, mythopoetics
The conditional mutations in D. melanogaster are produced by gamma-irradiation, maintained in laboratory cultures, and inherited as gene mutations. However, their manifestation differs from the conventional mutations by several specific features. The most noticeable specific feature is their conditional nature, i.e., a conditional mutation manifests itself in the individuals of a certain genotype being silent in the individuals with another genotype. A particular procedure for mutation recovery determines what these genotypes will be. An overwhelming number of mutations are conditional dominant lethals. The viable mutation carriers display a drastically decreased fertility. Early zygotic lethality is inherited according to parental type (maternal or paternal). The carriers of conditional mutations give the offspring with a high rate of monstrosities. The possibility for the offspring to form monstrosities is inherited according to a parental (maternal or paternal) type. The level of fertility of conditional mutants is altered by chromosomal rearrangements. The chromosomal rearrangements themselves cause a decrease in fertility. Lethality of the progenies produced by the parents carrying rearrangements is inherited according to a parental (maternal or paternal) type. The results allow for a set of logical arguments in favor of that 1) the genome has a specialized system of genes (ontogenes) that control the course of individual development; 2) unlike a classical gene, acting according to the scheme DNA à RNA à protein, the ontogene implements the regulation according to the scheme DNA à RNA; and 3) the course of individual development is programmed by double-strand RNAs produced by ontogenes in germline cells.
This study was carried out through 2010-2014, seasons on on …fresh herbs of Plantago major plant, which was collected from a private nurseries of El Qanater el Khayreyya, Al- Qaluobia Governorate, Egypt. The aim of this study was to investigate the protective potential of ethanolic crud extract of Plantago major against oxidative stress induced by carbon tetrachloride (CCl4) in different tissues in rats.

Our results observed that CCl4 exhibited a significant increase in the levels of serum glucose and lipid profile i.e. total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL) with a significant decrease in the level of high density lipoprotein cholesterol (HDL). Also, CCl4 increase liver function including serum aminotransferases (AST and ALT), alkaline phosphatase (ALPh), total protein, albumin (ALB) and total bilirubin activities and kidney function including the levels of serum urea, uric acid and creatinine amounts. Treatment with ethanolic P. major extract at 100mg/kg b.wt before, with and after treatment with CCl4 significantly prevented all of these typically observed changes . Also, P. major extract statistically significant (P<0.01) inhibit DNA damage induced by CCl4 in bone marrow and sperms of rats.

Our findings indicate that P. major has a significant protective effect against CCl4 induced genotoxicity and biochemical changes in rat, which may be due to its antioxidant properties.
Currently, cucurbiturils are being actively researched all over the world. Research is focused on the ways of improving the solubility and selectivity of cucurbiturils, increasing the stability of the complexes with other particles in various media and enhancing their ability to bind and release various substances. The most significant area of our research is the assessment of safety, studying the biological properties and synergistic effects of cucurbiturils during complexation with drugs. In this article, the hemocompatibility of erythrocytes and leukocytes with cucurbiturils was investigated. We demonstrated that cucurbiturils have no cytotoxic effect, even at high concentrations (1 mM) and do not affect the viability of PBMCs. However, cucurbiturils can increase the level of the early apoptosis of lymphocytes and cucurbit[7]uril enhances hemolysis in biologically relevant media. Despite this, cucurbiturils are fairly safe organic molecules in concentrations up to 0.3 mM. Thus, we believe that it will become possible to use polymer nanostructures as drug delivery systems in clinical practice, since cucurbiturils can be modified to improve pharmacological properties.
This paper is devoted to a mathematical model of a chaotic dynamics of a polymer chain in water. The model consists of a parabolic equation that is derived according to the self-consistent field approach. This model is employed for the numerical simulation of a biological sensor that detects the presence of a specific protein in the fluid. The sensor is absolutely simple and seems to be new. Besides that, the suggested equation is interesting from the mathematical point of view. It includes a non-local operator of integration not only over the past time interval as in the problems with memory but also over the future time interval. It is unusual for parabolic problems.
We consider the problem of existence of perfect $2$-colorings (equitable $2$-partitions) of Hamming graphs with given parameters. We start with conditions on parameters of graphs and colorings that are necessary for their existence. Next we observe known constructions of perfect colorings and propose some new ones giving new parameters. At last, we deduce which parameters of colorings are covered by these constructions and give tables of admissible parameters of $2$-colorings in Hamming graphs $H(n,q)$ for small $n$ and $q$. Using the connection with perfect colorings, we construct an orthogonal array OA(2048,7,4,5).
From 2011 to 2014, the BESIII experiment collected about 5 fb−1 data at center-of-mass energies around 4 GeV for the studies of the charmonium-like and higher excited charmonium states. By analyzing the di-muon process e+e− → γISR/FSRμ+μ−, the center-of-mass energies of the data samples are measured with a precision of 0.8 MeV. The center-of-mass energy is found to be stable for most of the time during data taking.
The Ni2P/SiO2 catalyst, which was prepared by in situ temperature-programmed reduction and in the mixture with the inert (SiC, SiO2) or acidic (γ-Al2O3) material was studied in methyl palmitate hydrodeoxygenation (HDO). Methyl palmitate HDO was carried out at temperatures of 270–330 °C, H2/feed volume ratio of 600 Nm3/m3, and H2 pressure of 3.0 MPa. Ni2P/SiO2 catalyst, diluted with γ-Al2O3 showed a higher activity than Ni2P/SiO2 catalyst diluted with SiC or SiO2. The conversion of methyl palmitate increased significantly in the presence of γ-Al2O3 most probably due to the acceleration of the acid-catalyzed reaction of ester hydrolysis. The synergism of Ni2P/SiO2 and γ-Al2O3 in methyl palmitate HDO can be explained by the cooperation of the metal sites of Ni2P/SiO2 and the acid sites of γ-Al2O3 in consecutive metal-catalyzed and acid-catalyzed reactions of HDO. The obtained results let us conclude that the balancing of metal and acid sites plays an important role in the development of the efficient catalyst for the HDO of fatty acid esters over supported phosphide catalysts.
Currently, there are a number of computer systems that allow the user to reconstruct molecular-genetic networks using the data automatically extracted from the texts of scientific publications. Examples of such systems are STRING, Pathway Commons, MetaCore and Ingenuity. The MetaCore and Ingenuity systems permit taking into account tissue-specific gene expression during the reconstruction of gene networks.

Previously, we developed the ANDSystem tool, which also provides an automated extraction of knowledge from scientific texts and allows the reconstruction of gene networks. The main difference between our system and other tools is in the different types of interactions between objects, which makes the ANDSystem complementary to existing well-known systems.

However, previous versions of the ANDSystem did not contain any information on tissue-specific expression.
A search for new physics in energetic, high-multiplicity final states has been performed using proton-proton collision data collected with the CMS detector at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 2.3 inverse femtobarns. The standard model background, dominated by multijet production, is determined exclusively from control regions in data. No statistically significant excess of events is observed. Model-independent limits on the product of the cross section and the acceptance of a new physics signal in these final states are set and further interpreted in terms of limits on the production of black holes. Semiclassical black holes and string balls with masses as high as 9.5 TeV, and quantum black holes with masses as high as 9.0 TeV are excluded by this search in the context of models with extra dimensions, thus significantly extending limits set at a center-of-mass energy of 8 TeV with the LHC Run 1 data.
Pyrrhotite (or Cu-poor) massive ores of the Skalisty mine located in Siberia, Russia, are unique in terms of their geochemical features. These ores are Ni-rich with Ni/Cu ratios in the range 1.3–1.9 and contain up to 12.25 ppm Ir + Rh + Ru in bulk composition, one of the highest IPGE contents for the Norilsk–Talnakh ore camp. The reasons behind such significant IPGE Contents cannot simply be explained by the influence of discrete platinum-group minerals on the final bulk composition of IPGE because only inclusions of Pd minerals such as menshikovite, majakite, and mertieite II in Pd-maucherite were observed. According to LA-ICP-MS data obtained, base metal sulfides such as pyrrhotite, pentlandite, and pyrite contain IPGE as the trace elements. The most significant IPGE concentrator being Py, which occurs only in the least fractionated ores, and contains Os up to 4.8 ppm, Ir about 6.9 ppm, Ru about 38.3 ppm, Rh about 36 ppm, and Pt about 62.6 ppm. High IPGE contents in the sulfide melt may be due to high degrees of partial melting of the mantle, interaction with several low-grade IPGE impulses of magma, and (or) fractionation of the sulfide melt in the magma chamber.
Background Oxidative stress plays an important role in the development of neurodegenerative diseases: it either can be the initiator or part of a pathological cascade leading to the neuron’s death. Although a lot of methods are known for oxidative stress study, most of them operate on non-native cellular substrates or interfere with the cell functioning. Genetically encoded (GE) biosensors of oxidative stress demonstrated their general functionality and overall safety in various live systems. However, there is still insufficient data regarding their use for research of disease-related phenotypes in relevant model systems, such as human cells.

Methods We applied CRISPR/Cas9 genome editing to introduce mutations (c.272A>C and c.382G>C) in the associated with amyotrophic lateral sclerosis SOD1 gene of induced pluripotent stem cells (iPSC) obtained from a healthy individual. Using CRISPR/Cas9, we modified these mutant iPSC lines, as well as the parental iPSC line, and a patient-specific SOD1 D91A/D91A iPSC line with ratiometric GE biosensors of cytoplasmic (Cyto-roGFP2-Orp1) and mitochondrial (Mito-roGFP2-Orp1) H 2 O 2 . The biosensors sequences along with a specific transactivator for doxycycline-controllable expression were inserted in the “safe harbor” AAVS1 (adeno-associated virus site 1) locus. We differentiated these transgenic iPSCs into motor neurons and investigated the functionality of the biosensors in such a system. We measured relative oxidation in the cultured motor neurons and its dependence on culture conditions, age, and genotype, as well as kinetics of H 2 O 2 elimination in real-time.

Results We developed a cell-based platform consisting of isogenic iPSC lines with different genotypes associated with amyotrophic lateral sclerosis. The iPSC lines were modified with GE biosensors of cytoplasmic and mitochondrial H 2 O 2 . We provide proof-of-principle data showing that this approach may be suitable for monitoring oxidative stress in cell models of various neurodegenerative diseases as the biosensors reflect the redox state of neurons. Conclusion We found that the GE biosensors inserted in the AAVS1 locus remain functional in motor neurons and reflect pathological features of mutant motor neurons, although the readout largely depends on the severity of the mutation.
We report the complex phase behavior of the glass forming protic ionic liquid (PIL) d3-octylphosphonium bis(trifluoromethylsulfonyl)imide [C
Synergistic effects between –NO2 groups and open metal sites lead to optimal binding of CO2 molecules within MFM-102-NO2via hydrogen bonding to C–H groups.
This article discusses the main facts about one of the leaders of the nomadic Ewenkis of Transbaikalia  Gantimur, who in 1666/67 left Qing empire and got through the process of naturalization in Russia. The author criticizes the narrative that is widespread in the state and local historical works and genealogical writings. According to it, Gantimur belonged to the Manchu ruling elite and allegedly participated in 1655 in the attack on the Russian Komarsky ostrog (fortress), located on the right bank of the Amur. Based on the analysis of a broad range of archival and published sources (petitions of Gantimur and his descendants, reports of Russian explorers and administrators, diplomatic documents drawn up during the Russian-Manchu negotiations) and historical research, it is shown, how this narrative appeared and became prevalent. The author proves that this historical myth does not correspond to real facts and was fabricated by the grandchildren of Gantimur in order to improve their status in the Russian social hierarchy and increase wealth. This article concludes by arguing that Gantimur was not part of the Manchu elite and did not take part in the Manchu campaigns on the Amur river.
Comorbid states of diseases significantly complicate diagnosis and treatment. Molecular mechanisms of comorbid states of asthma and hypertension are still poorly understood. Prioritization is a way for identifying genes involved in complex phenotypic traits. Existing methods of prioritization consider genetic, expression and evolutionary data, molecular-genetic networks and other. In the case of molecular-genetic networks, as a rule, protein-protein interactions and KEGG networks are used.

ANDSystem allows reconstructing associative gene networks, which include more than 20 types of interactions, including protein-protein interactions, expression regulation, transport, catalysis, etc. In this work, a set of genes has been prioritized to find genes potentially involved in asthma and hypertension comorbidity. The prioritization was carried out using well-known methods (ToppGene and Endeavor) and a cross-talk centrality criterion, calculated by analysis of associative gene networks from ANDSystem.

The identified genes, including IL1A, CD40LG, STAT3, IL15, FAS, APP, TLR2, C3, IL13 and CXCL10, may be involved in the molecular mechanisms of comorbid asthma/hypertension. An analysis of the dynamics of the frequency of mentioning the most priority genes in scientific publications revealed that the top 100 priority genes are significantly enriched with genes with increased positive dynamics, which may be a positive sign for further studies of these genes.