Hengzongshu/ArticleAgent huggingface dataset:
We present a study of ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$, ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$, ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$, and ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{K}^{+}{K}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ decays using a $666\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ data sample collected with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider at and near a center-of-mass energy of 10.58 GeV. The branching fractions are measured to be $\mathcal{B}({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}})=(8.42\ifmmode\pm\else\textpm\fi{}{0.00}_{\ensuremath{-}0.25}^{+0.26})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$, $\mathcal{B}({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}})=(3.30\ifmmode\pm\else\textpm\fi{}{0.01}_{\ensuremath{-}0.17}^{+0.16})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}$, $\mathcal{B}({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}})=(1.55\ifmmode\pm\else\textpm\fi{}{0.01}_{\ensuremath{-}0.05}^{+0.06})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}$, and $\mathcal{B}({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{K}^{+}{K}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}})=(3.29\ifmmode\pm\else\textpm\fi{}{0.17}_{\ensuremath{-}0.20}^{+0.19})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$, where the first uncertainty is statistical and the second is systematic. These branching fractions do not include contributions from modes in which a ${\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ pair originates from a ${K}_{S}^{0}$ decay. We also present the unfolded invariant mass distributions for these decays.
Chromosome pairing and recombination at meiosis involves scheduled formation and repair of double-strand breaks of DNA.Rad51, the eukaryotic homologue of the bacterial RecA protein, plays a crucial role in these processes.We used antibodies against human Rad51 to examine the temporal and spatial distribution of Rad51 in the spermatocytes of the common shrew Sorex araneus (Eulipotyphla, Soricidae).We found that hundreds of Rad51 foci appeared at leptotene.At the beginning of zygotene their close association with the axial elements of the synaptonemal complex became apparent.From early to late zygotene the number of Rad51 foci gradually decreased.At pachytene we observed a further dramatic decrease in the number of foci.They were distributed irregularly along autosomal bivalents.We detected a prevalence of Rad51 signals on the original X and autosomal arms of the sex trivalent at late pachytene.We did not detect a preferential association of Rad51 foci with unpaired or non-homologously paired regions of lateral elements of synaptonemal complexes in Robertsonian multivalents.
In the paper, the authors describe some results of a numerical simulation of the air flow around a bluff body mounted on a flat plate taking into account the injection of a tracer gas through a hole located in the substrate behind the body.

The aim of this paper is to describe flow structure in the vicinity of a prism taking into account unstable stratification of the boundary layer which is characterized by a negative vertical temperature gradient.

The results of numerical simulation for an unstable thermal state were compared with those obtained for the case of stable stratification for the same geometry configuration.
Terephthalonitrile dianion couples with biphenylcarbonitriles providing dicyanosubstituted mand p-terphenyls.The influence of the cyano group position in biphenylcarbonitrile on the structure of the terphenyl scaffold is discussed.
WebProAnalyst is a web-accessible analysis tool (http://wwwmgs.bionet.nsc.ru/mgs/programs/panalyst/) designed for scanning quantitative structure-activity relationships in protein families. The tool allows users to search correlations between protein activity and physicochemical characteristics (i.e. hydrophobicity or alpha-helical amphipathicity) in queried sequences. WebProAnalyst uses aligned amino acid sequences and data on protein activity (pK, K(m), ED(50), among others). WebProAnalyst implements methods of the known ProAnalyst package, including the multiple linear regression analysis and the sequence-activity correlation coefficient. In addition, WebProAnalyst incorporates a method based on neural networks. The WebProAnalyst reports a list of sites in protein family, the regression analysis parameters (including correlation values) for the relationships between the amino acid physicochemical characteristics in the site and the protein activity values. WebProAnalyst is useful in search of the amino acid residues that are important for protein function/activity. Furthermore, WebProAnalyst may be helpful in designing the protein-engineering experiments.
Nach Bestrahlung mit Licht können Kristalle aus bestimmten Materialien plötzlich hüpfen, um die Spannung freizusetzen, die sich in ihrem Inneren als Folge einer photochemischen Reaktion aufbaut. Dabei legen sie Strecken zurück, die 102- bis 105-mal länger als sie selbst sind. Dieser Effekt ist ein Beispiel für die schnelle Umwandlung von Licht in mechanische Bewegung auf makroskopischer Ebene. In der Zuschrift auf S. 10174 ff. analysieren P. Naumov, E. V. Boldyreva et al. die kinematischen Bewegungsmuster. Bild: Bailey Curzadd.
In Russia, cancer is the second leading cause of death following cardiovascular diseases. Adoptive transfer of NK cells is a promising approach to fight cancer; however, for their successful use in cancer treatment, it is necessary to ensure their robust accumulation at tumor foci, provide resistance to the immunosuppressive tumor microenvironment, and to engineer them with higher cytotoxic activity. NK lymphocytes are known to kill cancer cells expressing a number of stress ligands; and the balance of signals from inhibitory and activating receptors on the surface of the NK cell determines whether a cytotoxic reaction is triggered.

We hypothesized that stronger cytotoxicity of NK cells could be achieved via gene editing aimed at enhancing the activating signaling cascades and/or weakening the inhibitory ones, thereby shifting the balance of signals towards NK cell activation and target cell lysis. Here, we took advantage of the CRISPR/Cas9 system to introduce mutations in the coding sequence of the shp-2 (PTPN11) gene encoding the signaling molecule of inhibitory pathways in NK cells. These shp-2 knock-out NK cells were additionally transduced to express a chimeric antigen receptor (CAR) that selectively recognized the antigen of interest on the target cell surface and generated an activating signal.

We demonstrate that the combination of shp-2 gene knockout and CAR expression increases the cytotoxicity of effector NK-like YT cells against human prostate cancer cell line Du-145 with ectopic expression of PSMA protein, which is specifically targeted by the CAR.
The article discusses the security problems of the Central Asian region, closely related to the ongoing war in Afghanistan. The author sets out his understanding of the term “state security”, which includes the problems of the armed forces and security agencies, primarily responsible for the fight against terrorism and separatism. However, there is also an understanding of the current state of the economy, interethnic relations, the preservation of natural resources, and the balance of interests in international relations. In particular, an assessment is given of the mutual relations between the countries of Central Asia and China in connection with the implementation of the project “One belt – one way”. The situation in the region is characterized by a high degree of tension in neighboring Afghanistan, where armed conflicts continue between various local opposing forces, as well as American troops and the Taliban. Fighting in Afghanistan is an immediate threat to neighboring Central Asian states. In connection with the dangerous insecurity in Afghanistan, which negatively affects the situation in the entire Central Asian region, it is necessary to note the positive role of the Chinese leadership in its attempts to contribute to the settlement of the conflict. Beijing, interested in implementing its various infrastructure projects, provides its own platform for meetings between representatives of the warring parties, promoting mutual understanding.
The present study reviews the taxonomy of Late Jurassic-Early Cretaceous oysters from the Northern and the Subpolar Urals (Western Siberia) and northern East Siberia.Previous studies have documented 10 species from the genus Liostrea (L.delta, L. cucurbita, L. praeanabarensis, L. anabarensis, L. plastica, L. gibberosa, L
We consider a problem of formal evaluation of spatial resolution in seismic tomography. We have shown that a traditional method of resolution estimate based on calculation of the resolution matrix appears to be misleading in a case of using the parameterization grid with different spacing. We have proposed an alternative algorithm based on reconstruction of a series of unit anomalies of fixed shapes. Furthermore, we have developed an algorithm for the direction dependent resolution estimates.
The motivation of this joint complex studies is related to the actual necessity of analyzing the strong wind impact in the coastline of the "sea-land" typical for Taiwan Island, as well as due to the long-established creative collaboration between partners from the Khristianovich Institute of Theoretical and Applied Mechanics SB RAS and National Cheng Kung University in Taiwan. Experimental studies were carried out in wind tunnels in Novosibirsk and Taiwan, in particular, in November this year, planned further experiments in wind tunnels in Taiwan. Numerical studies were carried out mainly in St. Petersburg, where for more than twenty years the package VP2/3 (velocity-pressure, 2D/3D) has been developing. Interest to the flow past a semicircular cylinder is high due to its phenomenal characteristics: ultra-low negative lift at zero angle of attack. In this paper, this effect is explained numerically, and this body is recommended for testing methods, models and packages. The influence of the Mach number on the flow past a semicircular cylinder at zero angle of attack is illustrated in the Mach number range M = 0 - 0.5. Turbulent regime with a throttling effect gave an exceptional result - the stabilization of the flow in the wake behind the circular cylinder when air is gone through the outlet channel from the zone of increased pressure in front of the body with the release of the jet inside the near wake. There is made a comparison of the experimental behavior of the resistance of a circular cylinder with an increase in the Reynolds number and the calculated dependence for a cylinder in a casing with holes. A three-fold decrease in drag on high Re numbers was detected. Completion of the test section of the T-325M wind tunnel of ITAM SB RAS allowed to increase (in several times) the Reynolds number of an incompressible flow. Design and manufacturing of circular and semicircular cylinders having the structured surface has been performed, for which some preliminary physical experiments in the test section of T-325M wind tunnel of ITAM SB RAS within the Reynolds and Mach numbers range citied above were carried out.
A measurement of off-shell Higgs boson production in the $ZZ\to4\ell$ and $ZZ\to2\ell2\nu$ decay channels, where $\ell$ stands for either an electron or a muon, is performed using data from proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=13$ TeV.

The data were collected by the ATLAS experiment in 2015 and 2016 at the Large Hadron Collider, and they correspond to an integrated luminosity of 36.1 fb$^{-1}$.

An observed (expected) upper limit on the off-shell Higgs signal strength, defined as the event yield normalised to the Standard Model prediction, of 3.8 (3.4) is obtained at 95% confidence level (CL). Assuming the ratio of the Higgs boson couplings to the Standard Model predictions is independent of the momentum transfer of the Higgs production mechanism considered in the analysis, a combination with the on-shell signal-strength measurements yields an observed (expected) 95% CL upper limit on the Higgs boson total width of 14.4 (15.2) MeV.
The paper deals with the experimental study of the gas (nitrogen) driven rivulet flow regimes of water outflowing from the nozzle with a width of 10 mm into minichannel with the height of 1.6±0.02 mm and a width of 30 mm. The authors revealed a new flow regime – namely “rivulet bridge” whose occurrence is attributed to the influence of relatively large static wetting angle of water on the flow regimes. The paper presents a map of the various rivulet flow regimes characterized by different surface geometry and types of surface deformations.
The article analyzes the family system as an important factor and resource of development in the organization of assistance to a child with ASD. The results of an empirical study of parental burnout and family situation experience in relation to the nature of family communication in mothers and fathers of children with ASD are presented. In a sample of 47 parents aged from 27 to 54 years (20 fathers and 27 mothers; the average age of fathers is 39.5 + 6.1, the average age of mothers is 37.7 + 6.2), raising children with ASD, the material was collected using the author's questionnaire, the questionnaire “Parental burnout”, the method “Typical family status” and the projective method “Family sociogram”. The results of the study showed a higher level of emotional exhaustion in the group of mothers. Symbiotic, close intersecting relationships in the studied families, which serve as some support and support in the current situation, are accompanied by a decrease in the parents’ indicators of neuropsychic stress, while distancing in family relations, on the contrary, is accompanied by an increase in neuropsychic stress. It is also revealed that the preservation of marital relations is accompanied by the acceptance of oneself as a parent who adequately fulfills their parental functions.
The quantum numbers of the X(3872) meson are determined to be JPC = 1++ based on angular correlations in B+ to X(3872) K+ decays, where X(3872) to pi+pi- J/psi and J/psi to \mu+\mu-. The data correspond to 1.0 fb-1 of pp collisions collected by the LHCb detector. The only alternative assignment allowed by previous measurements, JPC=2-+, is rejected with a confidence level equivalent to more than eight Gaussian standard deviations using the likelihood-ratio test in the full angular phase space. This result favors exotic explanations of the X(3872) state.
The occurrence of snow avalanches is mainly influenced by meteorological conditions and the configuration of snow cover layers.

Machine learning methods have predictive power and are capable of predicting new events. From the trained machine learning models, an ensemble is obtained that predicts the possibility of avalanches. The model obtained in the article uses avalanche data, meteorological data and generated data on the state of snow cover for training. Snow data is generated by the SNOWPACK software package.

This allows the resulting solution to be used in more mountainous areas than solutions using a wider range of less available data.
The Geochemical and mineralogical studies showed, that harzburgites of the Chagan-Uzun massif are restites with a degree of partial melting 15–20 %, which formed at temperatures 1520–1420 ° С under the conditions of the mid-oceanic ridge and transformed during the evolution of paleooceanic structures under the influence of magmatic processes at the initial stages of subduction and manifestation of boninite magmatism.

The combined use of data on the geochemistry of rare and rare earth elements, as well as on the compositions of pyroxenes, Cr-spinels, melt inclusions in Cr-spinels and computational modeling, indicates the formation of clinopyroxenites of Chagan-Uzun ophiolites at the mid-oceanic ridge during crystallization of picrite and picrobasalt melts at temperatures 1315–1245 °C and pressures 4–2 kbar. The study of amphiboles showed high metamorphic parameters of transformation of harzburgites (5.1–1.9 kbar, 820–700 ° С ) and clinopyroxenites (2.6–1.4 kbar and 740–680 ° С ) of the Chagan-Uzun massif, typical for ultrabasites from the modern mid-oceanic ridges.

In general, results of comprehensive studies made it possible to determine the sequence of paleogeodynamic processes of formation of ultramafic rocks of the Chagan-Uzun massif. Initial formation of harzburgites in the course of partial melting of mantle and crystallization of clinopyroxenites in the magma chamber occurred under the conditions of the mid-oceanic ridge. At the next stage, ultramafic rocks fell within the subduction-zone initiation area, where they were exposed to the influence of boninite melts.
The desolvated (3,24)-connected metal–organic framework (MOF) material, MFM-160a, [Cu3(L)(H2O)3] [H6L = 1,3,5-triazine-2,4,6-tris(aminophenyl-4-isophthalic acid)], exhibits excellent high-pressure uptake of CO2 (110 wt% at 20 bar, 298 K) and highly selective separation of C2 hydrocarbons from CH4 at 1 bar pressure. Henry's law selectivities of 79:1 for C2H2:CH4 and 70:1 for C2H4:CH4 at 298 K are observed, consistent with ideal adsorption solution theory (IAST) predictions. Significantly, MFM-160a shows a selectivity of 16:1 for C2H2:CO2. Solid-state 2H NMR spectroscopic studies on partially deuterated MFM-160-d12 confirm an ultra-low barrier (∼2 kJ mol–1) to rotation of the phenyl group in the activated MOF and a rotation rate 5 orders of magnitude slower than usually observed for solid-state materials (1.4 × 106 Hz cf. 1011–1013 Hz). Upon introduction of CO2 or C2H2 into desolvated MFM-160a, this rate of rotation was found to increase with increasing gas pressure, a phenomenon attributed to the weakening of an intramolecular hydrogen bond in the triazine-containing linker upon gas binding. DFT calculations of binding energies and interactions of CO2 and C2H2 around the triazine core are entirely consistent with the 2H NMR spectroscopic observations.
The results of investigations of relaxation processes of donor bound electrons in the germanium doped by arsenic at cryogenic temperatures are presented. The lifetimes of p-type excited states of a donor were measured by pump-probe technique utilizing THz radiation from free-electron laser NovoFEL. The uniaxial stress along [111] axis was applied to the crystal to modify the energy spectrum of the impurity and intervalley relaxation processes. The analysis of experimental for p-type excited states allows to get the upper limit for the relaxation time of lowest 1s excited state. The comparison of obtained experimental results with the theoretical estimates for the interaction with TA phonons indicates on the enhancement of the interaction with the phonons having wavenumbers corresponding to the flat part of the dispersion.
The consumption of food rich in sugar and fat provokes obesity. Prenatal conditions have an impact on taste preferences and metabolism in the adult offspring, and this impact may manifest differently in different sexes. An increase in blood leptin level in pregnant females reduces the risk of obesity and insulin resistance in the offspring, although the mechanisms mediating this effect are unknown. Neither is it known whether maternal leptin affects taste preferences.

In this study, we investigated the effect of leptin administration to pregnant mice on the development of diet-induced obesity, food choice, and gene expression in the liver and muscles of the offspring with regard to sex. Leptin was administered to female mice on days 11, 12, and 13 of pregnancy. In male and female offspring, growth rate and intake of standard chow after weaning, obesity development, gene expression in the liver and muscles, and food choice when kept on a high-calorie diet (standard chow, lard, sweet cookies) were recorded.

Leptin administration to pregnant females reduced body weight in the female offspring fed on the standard diet. When the offspring were given a high-calorie diet, leptin administration inhibited obesity development and reduced the consumption of cookies only in males. It also increased the consumption of standard chow and the mRNA levels of genes for the insulin receptor and glucose transporter type 4 in the muscles of both male and female offspring. The results demonstrate that an increase in blood leptin levels in pregnant females has a sex-specific effect on the metabolism of the offspring increasing resistance to obesity only in male offspring. The mechanism underlying this effect includes a shift in food preference in favor of a balanced diet and maintenance of insulin sensitivity in muscle tissues.
Plant expression systems are currently regarded as promising alternative platforms for the production of recombinant proteins, including the proteins for biopharmaceutical purposes. However, the accumulation level of a target protein in plant expression systems is still rather low compared with the other existing systems, namely, mammalian, yeast, and E. coli cells. To solve this problem, numerous methods and approaches have been designed and developed. At the same time, the random nature of the distribution of transgenes over the genome can lead to gene silencing, variability in the accumulation of recombinant protein, and also to various insertional mutations.

The current research study considered inserting target genes into pre-selected regions of the plant genome (genomic 'safe harbors') using the CRISPR/Cas system. Regions of genes expressed constitutively and at a high transcriptional level in plant cells (housekeeping genes) that are of interest as attractive targets for the delivery of target genes were characterized. The approach of 'euchromatization' of the transgene integration region using the modified dCas9 associated with transcription factors is considered.

The results of the first attempts to deliver target genes to the regions of housekeeping genes are discussed. A number of the specific features in the spatial chromatin organization allowing individual genes to efficiently transcribe are discussed.
We give direct experimental evidence for the observation of the full transverse self-modulation of a relativistic proton bunch propagating through a dense plasma. The bunch exits the plasma with a density modulation resulting from radial wakefield effects with a period reciprocal to the plasma frequency. We show that the modulation is seeded by using an intense laser pulse co-propagating with the proton bunch which creates a relativistic ionization front within the bunch. We show by varying the plasma density over one order of magnitude that the modulation period scales with the expected dependence on the plasma density.