Hengzongshu/ArticleAgent huggingface dataset:
The aim of the study was to investigatey the association of single-nucleotide polymorphism (SNP) rs10507391 (A>T) with the acute cerebrovascular accident (CVA) development in patients of the East Siberian population with cardiovascular pathology and its risk factors. Material and methods. The study involved 260 patients with acute CVA (age [57.0; 51.0–62.0]) and 272 patients of the control group (age [55.0; 51.0–62.0]). Among the patients who had acute CVA there were 157 men and 103 women. The control group included 170 men and 102 women. The examination of the experimental group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily blood pressure and heart rate monitoring, and analysis of the blood coagulation system. In patients of the experimental group, the following cardiovascular pathology and risk factors were present: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, and disorders of the hemostatic system. The control group was surveyed in the framework of the international “HAPIEE” project. Molecular genetic research was performed by real-time PCR. Statistical processing of the material was carried out using the following software: Statistica for Windows 7.0, Excel and SPSS 22. Results. When studying the association of SNP rs10507391 (A>T) with the acute CVA development in all the analyzed groups and subgroups of patients, a link was established between the rare TT genotype and the T allele and an increased risk of acute CVA. Conclusion. TT genotype and T allele of the SNP rs10507391 (A>T) increase the risk of acute CVA in patients regardless of previous cardiovascular pathology and its risk factors, including patients with arterial hypertension, supraventricular tachyarrhythmias, atherosclerosis of brachiocephalic arteries, impaired lipid metabolism and hemostasis system.
In this article, authors analyze zoomorphic metaphor that the Chinese and the Japanese used when they characterize the Russians.

On the first stage of study we did associative experiment with questionnaire. 100 of Chinese students and 100 of Japanese students took part. On the base of analyze of answers we selected by three typical zoonymes in Chinese and Japanese culture charactering the Russians. On the second stage of study we have analyzed associations and images of these animals existing in Russian, Chinese and Japanese linguistic cultures.

The Russians have images of bear, wolf and panther in Chinese culture and bear, wolf and fox in Japanese culture. It must be marked that all images are ambivalent and have as positive as negative characteristics. Because of the image of animals are different in Chinese and Japanese culture, the associations connecting with these animals are also different. But as the Chinese as the Japanese pay attentions on the appearance, then for the Chinese behavior is important, but for the Japanese color, place of living connecting with cold and woolen cloth that the Russian are dressed are important. The association on contiguity (the wool in animal, the cloth in man) is appeared. The white color is also important because it is associated with color of skin. The color is specified in zoonymes used by the Japanese the next way: bear 28 times, hare 10 times, hamster 9 times, fox 6 times, horse 3 times and squirrel 3 times. As for the Chinese this parameter is not important. Zoomorphic metaphor used in the relation with the Russians is connected with the following parameters. As for the Chinese with -physical characteristics (powerful, strong and, hard); imagination about Russian nation as a military nation; behavior (rough, aggressive and slow); character (open-hearted, kind and brave). As for the Japanese with appearance (beautiful, tall and white); place of living (cold place, many woolen dresses, resistant to the cold); behavior (slow, not pay attention to the surrounding people); size (big); physical characteristics (powerful).
The paper reports on a new plasma startup scenario in the Gas Dynamic Trap (GDT) magnetic mirror device. The primary 5 MW neutral beam injection (NBI) plasma heating system fires into a sufficiently dense plasma target ("seed plasma"), which is commonly supplied by an arc plasma generator.

In the reported experiments, a different approach to seed plasma generation is explored. One of the channels of the electron cyclotron resonance (ECR) heating system is used to ionize the neutral gas and build up the density of plasma to a level suitable for NBI capture. The paper presents the discharge scenario and experimental data on the seed plasma evolution during ECR heating, along with the dependencies on incident microwave power, magnetic configuration and pressure of a neutral gas.

After a short transition (about 1 ms) the discharge becomes essentially similar to a standard one initiated by the plasma gun. The characteristics of consequent high-power NBI discharge are studied and differences to the conventional scenario are discussed. A theoretical model describing the ECR breakdown and the seed plasma accumulation in a large scale mirror trap is developed on the basis of the GDT experiment.
Accuracy of the horizontal well placement in the target reservoir becomes essential for efficient oilfield development. Geosteering of a well with a complex trajectory is performed using real-time geophysical data obtained while drilling.

The presented work is devoted to the development of a new software for horizontal oil and gas wells geosteering. Algorithms based on logging data correlation and electromagnetic logging data numerical inversion methods are used for well placement.

The developed application is based on web-technologies and has a client-server architecture. To optimize the resource-intensive calculations execution time, high-performance cloud computing is used.
The article is devoted to a number of solutions for organizing work with memory in educational languages and programming systems aimed at teaching the preparation of multi-threaded programs over shared memory. The consideration was carried out within the framework of the SYNCHRO programming language for educational purposes, which made it possible to analyze variants of such solutions without the limitations typical for traditional manufacturing tools and devices of standard programming systems.

The article gives a clear formulation of an abstract machine and a diagram of a command system that allows you to define the behavior of a program as a distributed system from a number of threads interacting in terms of access to the values of variables located in shared memory. The device of shared memory and mechanisms of access to it by individual processes, which are a sequence of command execution, some of which are requests to shared memory, are described. The focus is on the convenience of debugging small programs used to introduce concurrency problems in the learning process, where the pace of learners’ understanding of the problems is more important than achieving program efficiency and performance. When choosing a system of commands for an abstract machine, the principles of functional programming were taken into account as a popular paradigm at the stage of preparing prototypes and models of multi-threaded programs.

From these principles, the conclusion is drawn of the consequences that allow you to successfully select elementary instructions that support working with memory in the style of data immutability and their transactional processing. For educational tasks in programming, the ability to ensure the correctness and completeness of solutions is more important than the efficiency and productivity of the received programs. This is the path to building reliable and secure software. The solution to this problem is useful when studying programming methods, as well as studying the history of programming languages, comparing programming paradigms, the potential of the schemes and models used, assessing the level of novelty of the programming languages being created, creating a technique for measuring different characteristics of programs on models and choosing criteria for the practicality of the created programs.
This abstract book contains abstracts of the various research ideas presented at The Second Eurasian RISK-2020 Conference and Symposium.The RISK-2020 Conference and Symposium served as a perfect venue for practitioners, engineers, researchers, scientists, managers and decision-makers from all over the world to exchange ideas and technology about the latest innovation developments dealing with risk minimization.
The project of heavy ion beam probe (HIBP) in Gas-Dynamic Trap (GDT) device is presented in the paper. HIBP will be placed at the midplane of GDT. It will measure electric potential in 8 positions along the plasma diameter simultaneously. Beam of primary ions Xe+1 is produced by 4-electrode accelerating system and has the following parameters: current up to 7 mA, ion energy of 60-76 keV, size of 4 mm and angular spread at the level of 1/e about 4 mrad. Secondary ions Xe+2 are produced by primary beam ionization in plasma and enter the small aperture detector based on 30-degrees electrostatic energy analyzer. Each detector channel provides potential measurement with accuracy of 10-50 V and spatial resolution of 2 cm at sampling rate up to 1 MHz.
In the paper the new experimental data are presented to study the gas-liquid flow in minichannels with a thickness of 1 mm and 1.2 mm in isothermal conditions. The design (fluid input conditions) and the width of the channels were changed.

The boundaries between the patterns of the gas-liquid flow were determined. Gas-liquid flow regimes maps were created. The patterns of a gas-liquid flow and transition between flow patterns were analyzed in detail. It made possible to find out the features of the gas-liquid flow in the solar collectors minichannels.
The study and comparison of mutation(al) spectra is an important problem in molecular biology, because these spectra often reflect on important features of mutations and their fixation. Such features include the interaction of DNA with various mutagens, the function of repair/replication enzymes, and properties of target proteins. It is known that mutability varies significantly along nucleotide sequences, such that mutations often concentrate at certain positions, called "hotspots," in a sequence.

In this paper, we discuss in detail two approaches for mutation spectra analysis: the comparison of mutation spectra with a HG-PUBL program, (FTP: sunsite.unc.edu/pub/academic/biology/dna-mutations/hyperg) and hotspot prediction with the CLUSTERM program (www.itba.mi.cnr.it/webmutation; ftp.bionet.nsc.ru/pub/biology/dbms/clusterm.zip). Several other approaches for mutational spectra analysis, such as the analysis of a target protein structure, hotspot context revealing, multiple spectra comparisons, as well as a number of mutation databases are briefly described.

Mutation spectra in the lacI gene of E. coli and the human p53 gene are used for illustration of various difficulties of such analysis.
Background. Barley ( Hordeum vulgare L.) and oat ( Avena sativa L.) are grain crops belonging to one of the main sources of food and forage in the Russian Federation. They contain proteins, various groups of vitamins, fats, carbohydrates, β-glucans, minerals and different bioloactive compounds, including anthocyanins. Recently, much attention has been given to anthocyanins due to their various valuable properties. Therefore, the grain of barley and oat is a potentially promising economic product and a component of functional nutrition.

Materials and methods. 32 barley and 11 oat accessions were studied by spectrophotometry. Anthocyanins were extracted from barley and oat kernels with a 1% HCl solution in methanol.

Results and discussion. As a result of the study, accessions and varieties with the highest content of anthocyanins were identified: for barley these are k-15904 (China), k-19906 (Mongolia), k-18709 (Japan), k-18723, k-18729 (Canada), k-17725 (Turkey) belonging to var. violaceum ; k-29568 (Japan) – var. densoviolaceum ; k-8690 (Ethiopia) – var. griseinigrum ; k-28205 (Germany) – var. nudidubium ; and for oat these are k-15527 ( A. ayssinica Hochst. var. braunii Koern., Ethiopia) and k-15245 ( A. strigosa Schreb. subsp. brevis var. tephera Mordv. ex Sold. et Rod., Poland). Conclusion. The obtained results demonstrated that the VIR collection includes accessions with potential value for the development of varieties with an increased anthocyanin content, which can be used as functional food products.
The research is devoted to the scientific justification of metal processing by pressure with the help of thick monolithic plates forming (thickness 40 mm) from the V95 (analog 7475) (Al-Zn-Mg-Cu) and V-1461 (analog 2099) (Al-Cu-Li-Zn) alloys in creep and close-to-superplasticity.

Optimum parameters of the technological process of plate forming are described. The effect of temperature on the magnitude of mechanical stresses (relaxation) during the tests of materials on pure bending is experimentally determined. Forming of thick plates (40 mm) on the UFP-1M unit, and the control of the obtained surface, in comparison with the given electronic model, made it possible to experimentally determine the time and number of forming stages.

Mechanical properties of the material after the technological process and heat treatment are preliminary evaluated. The efficiency of using the obtained parameters of the technological process and treatment of metals by pressure in such methods in general is shown.
Visualizations are used to better understand collections of scientific publications. Various methods of analyzing text collections can be used to build these visualizations.

This article discusses two methods Paper2vec and Cite2vec that get vector representations of documents using citation information.

To demonstrate a work of these techniques and an example of their application, visualizations were developed, which are described in this paper.
We introduce a thermodynamical model of filament growing when a current pulse via memristor flows.

The model is the boundary value problem, which includes nonstationary heat conduction equation with non-linear Joule heat source, Poisson equation, and Shockley-Read-Hall equations taking into account strong electron-phonon interactions in trap ionization and charge transport processes. The charge current, which defines the heating in the model, depends on the rate of the oxygen vacancy generation. The latter depends on the local temperature.

The solution of the introduced problem allows one to describe the kinetics of the switch process and the final filament morphology.
Reliable transcription factor binding site (TFBS) prediction methods are essential for computer annotation of large amount of genome sequence data. However, current methods to predict TFBSs are hampered by the high false-positive rates that occur when only sequence conservation at the core binding-sites is considered. To improve this situation, we have quantified the performance of several Position Weight Matrix (PWM) algorithms, using exhaustive approaches to find their optimal length and position. We applied these approaches to bio-medically important TFBSs involved in the regulation of cell growth and proliferation as well as in inflammatory, immune, and antiviral responses (NF-κB, ISGF3, IRF1, STAT1), obesity and lipid metabolism (PPAR, SREBP, HNF4), regulation of the steroidogenic (SF-1) and cell cycle (E2F) genes expression. We have also gained extra specificity using a method, entitled SiteGA, which takes into account structural interactions within TFBS core and flanking regions, using a genetic algorithm (GA) with a discriminant function of locally positioned dinucleotide (LPD) frequencies. To ensure a higher confidence in our approach, we applied resampling-jackknife and bootstrap tests for the comparison, it appears that, optimized PWM and SiteGA have shown similar recognition performances. Then we applied SiteGA and optimized PWMs (both separately and together) to sequences in the Eukaryotic Promoter Database (EPD). The resulting SiteGA recognition models can now be used to search sequences for BSs using the web tool, SiteGA. Analysis of dependencies between close and distant LPDs revealed by SiteGA models has shown that the most significant correlations are between close LPDs, and are generally located in the core (footprint) region. A greater number of less significant correlations are mainly between distant LPDs, which spanned both core and flanking regions. When SiteGA and optimized PWM models were applied together, this substantially reduced false positives at least at higher stringencies. Based on this analysis, SiteGA adds substantial specificity even to optimized PWMs and may be considered for large-scale genome analysis. It adds to the range of techniques available for TFBS prediction, and EPD analysis has led to a list of genes which appear to be regulated by the above TFs.
We consider a six-dimensional (1,0) hypermultiplet model coupled to an external field of vector/tensor system

Manifestly a (1,0) supersymmetric procedure of computing the effective action is developed in the framework of the superfield proper-time technique

The leading low-energy contribution to the effective action is calculated
previous measurements

We perform a measurement of the tau -> l gamma nu anti-nu (l = e, mu) branching fractions for a minimum photon energy of 10 MeV in the tau rest frame, using 431fb^-1 of e^+e^- collisions collected at the center-of-mass energy of the Upsilon(4S) resonance with the BaBar detector at the PEP-II storage rings

We find B(tau -> mu gamma nu anti-nu ) = (3.69pm0.03pm0.10)x10^-3, and B(tau -> e gamma nu anti-nu ) = (1.847pm0.015pm0.052)x10^-2, where the first quoted error is statistical, and the second is systematic. These results are substantially more precise than previous measurements
Difficulties related to the subjective perception of patients of his condition has limited the possibility of increasing daily dose of isotretinoin, and the lack of result from the previous therapy with basic medications has made isotretinoin a drug of choice.

The article presents 3 clinical observations of women of 51, 55 and 57 years old with severe rosacea, who reached the state of remission after a prolonged course of systemic therapy with low doses of isotretinoin.

Cumulative dose of isotretinoin for persistent clinical remission was 46.4 mg/kg of weight, 17.6 mg/kg, 12.6 mg/kg respectively.
We report the results of a study of $B^{\pm}\to K^{\pm}\eta_c$ and $B^{\pm}\to K^{\pm}\eta_c(2S)$ decays followed by $\eta_c$ and $\eta_c(2S)$ decays to $(K_SK\pi)^0$.

The results are obtained from a data sample containing 535 million $B\bar{B}$-meson pairs collected by the Belle experiment at the KEKB $e^+e^-$ collider. We measure the products of the branching fractions ${\mathcal B}(B^{\pm}\to K^{\pm}\eta_c){\mathcal B}(\eta_c\to K_S K^{\pm}\pi^{\mp})=(26.7\pm 1.4(stat)^{+2.9}_{-2.6}(syst)\pm 4.9(model))\times 10^{-6}$ and ${\mathcal B}(B^{\pm}\to K^{\pm}\eta_c(2S)){\mathcal B}(\eta_c(2S)\to K_S K^{\pm}\pi^{\mp})=(3.4^{+2.2}_{-1.5}(stat+model)^{+0.5}_{-0.4} syst))\times 10^{-6}$. Interference with the non-resonant component leads to significant model uncertainty in the measurement of these product branching fractions. Our analysis accounts for this interference and allows the model uncertainty to be reduced.

We also obtain the following charmonia masses and widths: $M(\eta_c)=(2985.4\pm 1.5(stat)^{+0.5}_{-2.0}(syst))$ MeV/$c^2$, $\Gamma(\eta_c)=(35.1\pm 3.1(stat)^{+1.0}_{-1.6}(syst))$ MeV/$c^2$, $M(\eta_c(2S))=(3636.1^{+3.9}_{-4.2}(stat+model)^{+0.7}_{-2.0}(syst))$ MeV/$c^2$, $\Gamma(\eta_c(2S))=(6.6^{+8.4}_{-5.1}(stat+model)^{+2.6}_{-0.9}(syst))$ MeV/$c^2$.
A large data sample of e + e - → 4π collected by the CMD-3 experiment at the VEPP-2000 e + e − collider

allowed for an amplitude analysis of the process e + e − → 4π in the center-of-mass energy range 900–2000 MeV

Various intermediate components were distinguished and dominance of the ωπ 0 and a 1 π amplitudes has been proved
An experimental study of the flow of a water film over a heated surface for Re = 15-50 was performed. The influence of the development of thermocapillary instability on the wave amplitudes, the deformation of the surface of the liquid film, and the formation of the first stable dry spot on the heater are investigated. It is shown that the interaction of waves with thermocapillary structures can lead to an increase in the critical heat flux corresponding to the rupture of the liquid film, as compared with the data known in the literature.
Methylotrophic yeasts have been used as the platform for expression of heterologous proteins since the 1980’s. They are highly productive and allow producing eukaryotic proteins with an acceptable glycosylation level. The first Pichia pastoris-based system for expression of recombinant protein was developed on the basis of the treeexudate-derived strain obtained in the US southwest. Being distributed free of charge for scientific purposes, this system has become popular around the world. As methylotrophic yeasts were classified in accordance with biomolecular markers, strains used for production of recombinant protein were reclassified as Komagataella phaffii.

Although patent legislation suggests free access to these yeasts, they have been distributed on a contract basis. Whereas their status for commercial use is undetermined, the search for alternative stains for expression of recombinant protein continues. Strains of other species of methylotrophic yeasts have been adapted, among which the genus Ogataearepresentatives prevail. Despite the phylogenetic gap between the genus Ogataeaand the genus Komagataellarepresentatives, it turned out possible to use classic vectors and promoters for expression of recombinant protein in all cases. There exist expression systems based on other strains of the genus Komagataellaas well as the genus Candida.

The potential of these microorganisms for genetic engineering is far from exhausted. Both improvement of existing expression systems and development of new ones on the basis of strains obtained from nature are advantageous. Historically, strains obtained on the southwest of the USA were used as expression systems up to 2009. Currently, expression systems based on strains obtained in Thailand are gaining popularity. Since this group of microorganisms is widely represented around the world both in nature and in urban environments, it may reasonably be expected that new expression systems for recombinant proteins based on strains obtained in other regions of the globe will appear.