Hengzongshu/ArticleAgent huggingface dataset:
Cardiac anesthetics rely heavily on opioids, with the standard patient receiving between 70 and 105 morphine sulfate equivalents (MSE; 10–15 µg/kg of fentanyl). A central tenet of Enhanced Recovery Programs (ERP) is the use of multimodal analgesia. This study was performed to assess the association between nonopioid interventions employed as part of an ERP for cardiac surgery and intraoperative opioid administration.

This study represents a post hoc secondary analysis of data obtained from an institutional ERP for cardiac surgery. Consecutive patients undergoing cardiac surgery received 5 nonopioid interventions, including preoperative gabapentin and acetaminophen, intraoperative dexmedetomidine and ketamine infusions, and regional analgesia via serratus anterior plane block. The primary objective, the association between intraoperative opioid administration and the number of interventions provided, was assessed via a linear mixed-effects regression model. To assess the association between intraoperative opioid administration and postoperative outcomes, patients were stratified into high (>50 MSE) and low (≤50 MSE) opioids, 1:1 propensity matched based on 15 patients and procedure covariables and assessed for associations with postoperative outcomes of interest. To investigate the impact of further opioid restriction, ultralow (≤25 MSE) opioid participants were then identified, 1:3 propensity matched to high opioid patients, and similarly compared.

A total of 451 patients were included in the overall analysis. Analysis of the primary objective revealed that intraoperative opioid administration was inversely related to the number of interventions employed (estimated −7.96 MSE per intervention, 95% confidence interval [CI], −9.82 to −6.10, P < .001). No differences were detected between low (n = 136) and high (n = 136) opioid patients in postoperative complications, postoperative pain scores, time to extubation, or length of stay. No differences were found in outcomes between ultralow (n = 63) and high (n = 132) opioid participants. Nonopioid interventions employed as part of an ERP for cardiac surgery were associated with a reduction of intraoperative opioid administration. Low and ultralow opioid use was not associated with significant differences in postoperative outcomes. These findings are hypothesis-generating, and future prospective studies are necessary to establish the role of opioid-sparing strategies in the setting of cardiac surgery.
The approach to the problem of hydraulic fracturing design optimization is proposed which combines three modules: a fracture geometry module, an oil production module and an economic module. The approach is based on the genetic algorithm — the universal multivariate and multiobjective optimization method. The optimization process involves subsequent determination of the fracture geometry, calculation of the oil production depending on the number of fractures, and description of the investment–return cash flows. Iterated by the genetic algorithm for different set of input parameters, this approach allows determination of the optimal design of a multiply fractured well for a given set of geological and economical information.

The results show that the proposed method is plausible and can be useful for achieving projected objectives.
One of concepts giving opportunities for studying of topological insulators in non-magnetic materials, or creating scattering-immune in optical waveguides is creation of synthetic gauge fields in photonic systems. It was shown that gauge fields shift the band-gaps of optical waves, which can be applied to implement one-way nonreciprocal waveguides, even though both the waveguide core and cladding are in a topologically trivial state [1]. In our work we propose a method to create a gauge field in a synthetic photonic mesh lattice – an optical device proved its high versatility for optical experiments [2]. We demonstrate presence of localized modes due to nontrivial gauge field circulation.
The purpose of analyzing possible interpretations of the antithesis Sense and Sensibility in the title of J. Austen's novel is to provide a theoretical basis for the author’s broader research. Presented also in other articles, the entire study is devoted to the analysis of different interpretations of the antithesis in French and Russian translations: both in the title and in the main message (macrocontext) of the novel. As a practical part of the research, the author presents in the current article her own arguments related to possible new interpretations of the antithesis. Namely: 1) hypothesis about a dual nature in the meaning of the antithesis itself: not only the traditional opposition "reason vs. feelings", but also the sense of objective reality vs. individual’s subjective sensibility; 2) comparison of the moral message of the novel (opposition "reason vs. feelings" in favor of the merits of reason) and modern theories of emotional intelligence. The author tries to prove that the four-branch model of emotional intelligence by P. Salovey and J. Mayer is based on the classic message – the merits of reason, however completed with commercial and pragmatic aspects. In addition, this new interpretation of the antithesis (sense of objective reality vs. individual’s subjective sensibility) is complemented by the author with her own possible Russian versions of the novel title, reflecting the new meaning and at the same time preserving the alliteration that the English original has.
The paper examines the problems of assessing the long-term impact of intensive exploitation of natural resources on the environment of a large region. Data for empirical study obtained from information of Rosstat and Annual State Reports «On the state and protection of the environment of the Russian Federation».

The vast territory of Asian Russia was chosen as the object of research. The results indicate a significant increase in environmental problems at each stage of industrial development in this region.

These problems are especially acute in connection with the entry of Asian Russia into the next wave of accelerated industrialization of raw materials, characterized by a significant expansion of projects for the extraction and processing of solid minerals and hydrocarbons. This requires improving institutional mechanisms for regulating environmental protection to increase the sustainability of the region's development.
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. People infected with HIV-1 are a particularly vulnerable group, as they may be at a higher risk than the general population of contracting COVID-19 with clinical complications. For such patients, drugs with a broad spectrum of antiviral activity are of paramount importance. Glycyrrhizinic acid (Glyc) and its derivatives are promising biologically active compounds for the development of such broad-spectrum antiviral agents.

In this work, derivatives of Glyc obtained by acylation with nicotinic acid were investigated. The resulting preparation, Glycyvir, is a multi-component mixture containing mainly mono-, di-, tri- and tetranicotinates. The composition of Glycyvir was characterized by HPLC-MS/MS and its toxicity assessed in cell culture. Antiviral activity against three strains of SARS-CoV-2 was tested in vitro on Vero E6 cells by MTT assay.

Glycyvir was shown to inhibit SARS-CoV-2 replication in vitro (IC
Age-related macular degeneration (AMD), a neurodegenerative and vascular retinal disease, is the leading cause of blindness in the developed world. Accumulating evidence suggests that alterations in the expression of a small heat shock protein (αB-crystallin) are involved in the pathogeneses of AMD.

Here we demonstrate that senescence-accelerated OXYS rats—an animal model of the dry form of AMD—develop spontaneous retinopathy against the background of reduced expression of αB-crystallin in the retina at the early preclinical stages of retinopathy (age 20 days) as well as at 4 and 24 months of age, during the progressive stage of the disease. The level of αA-crystallin expression in the retina of OXYS rats at all the ages examined was no different from that in disease-free Wistar rats. Treatment with the mitochondria-targeted antioxidant SkQ1 (plastoquinonyl-decyltriphenylphosphonium) from 1.5 to 4 months of age, 250 nmol/kg, increased the level of αB-crystallin expression in the retina of OXYS rats.

SkQ1 slowed the development of retinopathy and reduced histological aberrations in retinal pigment epithelium cells. SkQ1 also attenuated neurodegenerative changes in the photoreceptors and facilitated circulation in choroid blood vessels in the retina of OXYS rats; this improvement was probably linked with the restoration of αB-crystallin expression.
Berriasian (Early Cretaceous) oyster Pycnogryphaea weberae from Crimea is one of the earliest known pycnodonteine oysters.

Examination of shell morphology and microstructure of this species shows that it shares characters of the subfamilies Gryphaeinae and Pycnodonteinae.Shell microstructure of Pycnogryphaea weberae lacks vesicular structure and is similar to microstructure of the genus Gryphaea.At the same time the shell of this species possesses morphological characters typical of pycnodonteins: development of chomata and well-defined circumferential curb.

Pycnogryphaea weberae is regarded as a transitional taxon between the subfamilies Gryphaeinae and Pycnodonteinae and referred herein to a new genus Pycnogryphaea within the Pycnodonteinae.This suggests that the subfamily Pycnodonteinae likely originated from the Late Jurassic representatives of the genus Gryphaea (Gryphaeinae) in Berriassian.First pycnodonteins preserved shell microstructure of the genus Gryphaea but developed chomata along all the perimeter of both valves.
Among breast cancer (BC) patients the outcomes of anticancer therapy vary dramatically due to the highly heterogeneous molecular characteristics of BC. Therefore, an extended panel of BC cell lines are required for in vitro and in vivo studies to find out new characteristic of carcinogenesis and metastasis.

Breast cancer cells were prepared by optimizing technique from tumor samples. We used real-time RT-PCR, flow cytometry, western blotting, cytotoxicity assay, karyotyping and fluorescent and electron microscopy analyses to characterize the established cell lines. BC xenografts in scid mice were used for in vivo tumorigenicity studies.

The technique of preparing primary cells was optimized and this resulted in a high output of viable and active proliferated cells of nine patient-derived breast cancer cell lines and one breast non-malignant cell line. High E-cadherine and EpCAM expression correlated positively with epithelial phenotype while high expression of N-cadherine and Vimentin were shown in cells with mesenchymal phenotype. All mesenchymal-like cell lines were high HER3-positive-up to 90%. More interesting than that, is that two cell lines under specific culturing conditions (pulsed hypoxia and conditioned media) progressively transformed from mesenchymal to epithelial phenotypes displaying the expression of respective molecular markers proving that the mesenchymal-to-epithelial transition occurred. Becoming epithelial, these cells have lost HER3 and decreased HER2 membrane receptors. Three of the established epithelial cancer cell lines were tumorigenic in SCID mice and the generated tumors exhibited lobules-like structures. Ultrastructure analysis revealed low-differentiate phenotype of tumorigenic cell lines. These cells were in near-triploid range with multiple chromosome rearrangements. Tumorigenic BrCCh4e cells, originated from the patient of four-course chemotherapy, initiated metastasis when they were grafted subcutaneous with colonization of mediastinum lymph nodes.The developed BC cells metastasizing to mediastinum lymph nodes are a relevant model for downstream applications. Moreover, our findings demonstrate that pulsed hypoxia induces transformation of primary fibroblastoid breast cancer cells to epithelial-like cells and both of these cultures-induced and original-don't show tumor initiating capacity.
NMR hyperpolarization techniques enhance nuclear spin polarization by several orders of magnitude resulting in corresponding sensitivity gains. This enormous sensitivity gain enables new applications ranging from studies of small molecules by using high‐resolution NMR spectroscopy to real‐time metabolic imaging in vivo . Several hyperpolarization techniques exist for hyperpolarization of a large repertoire of nuclear spins, although the 13 C and 15 N sites of biocompatible agents are the key targets due to their widespread use in biochemical pathways. Moreover, their long T 1 allows hyperpolarized states to be retained for up to tens of minutes. Signal amplification by reversible exchange (SABRE) is a low‐cost and ultrafast hyperpolarization technique that has been shown to be versatile for the hyperpolarization of 15 N nuclei. Although large sensitivity gains are enabled by hyperpolarization, 15 N natural abundance is only ∼0.4 %, so isotopic labeling of the molecules to be hyperpolarized is required in order to take full advantage of the hyperpolarized state. Herein, we describe selected advances in the preparation of 15 N‐labeled compounds with the primary emphasis on using these compounds for SABRE polarization in microtesla magnetic fields through spontaneous polarization transfer from parahydrogen. Also, these principles can certainly be applied for hyperpolarization of these emerging contrast agents using dynamic nuclear polarization and other techniques.
A pioneering research on a self-assembly of the magneto-anisotropic module [Re(CN)7]3− with the Mn(III) complexes involving Salen type (N,N′-ethylenebis(salicylideneiminate)) Schiff base (SB) ligands was performed using the known [Mn(3MeOSalen)(H2O)2]2(ClO4)2·H2O (1) and the firstly synthesized [Mn2(5MeSalen)2OAc]PF6 (2).

In the case of 1, a slow diffusion of the component solutions led to the ionic compound Ph4P[Mn(3MeOSalen)(H2O)2]2[Re(CN)7]·6H2O (3). The direct mixing of the same solutions has resulted in the microcrystalline nearly insoluble solid [Mn(3MeOSalen)(H2O))4Re(CN)7]ClO4·1.5MeCN·6.5H2O, which is likely to comprise the pentanuclear clusters [(MnIII(SB)(H2O))4Re(CN)7]+. The use of 2 resulted in a 2D-network assembly of octanuclear clusters, [{(Mn(5MeSalen))6(H2O)2Re(CN)7}2Re(CN)7]Cl2(PF6)·H2O (4), incorporating one Re-center in a pentagonal bipyramid coordination environment, while another has strongly distorted capped trigonal prism as a coordination polyhedron. A synthetic challenge to obtain the 0D assemblies with Re:Mn ≥ 3 has yielded a hexanuclear complex [Mn(5MeSalen)H2O(i-PrOH)][(Mn(5MeSalen))5H2O(i-PrOH)2Re(CN)7](PF6)2(OAc)·2i-PrOH (5) being 1D chain via a bridging phenoxyl group. Owing to a low solubility of the final product, an addition of a bulk anion Ph4B− to the MeCN/MeOH solution of [Re(CN)7]3−and 1 in ratio 1:6 resulted in rhenium-free matter [Mn(3MeOSalen)(H2O)2][Mn(3MeOSalen)(H2O)MeCN](Ph4B)2·5MeCN (6).

The latter was observed for the first time for Re(IV) complexes.
The results of numerical investigation of the ignition of a stoichiometric methane-air mixture in the presence of carbon particles with diameters of 20-52 μm in the temperature range 950-1150 K and pressures of 1.5-2.0 MPa are presented. The calculated data of the ignition delay times of coal particles in the coal particles/air mixture and of the ignition delay times of methane and coal particles in the methane/coal particles /air mixture are compared with the experimental ones.

A satisfactory agreement of the data on the coal particles ignition delay times and methane ignition delay times in all the mixtures considered is shown.
Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter.

We search for single-photon events in 53 fb−1 of e+e− collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A′ through the process e+e−→γA′; A′→invisible.

We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A′ to e+e− in the mass range mA′≤8 GeV. In particular, our limits exclude the values of the A′ coupling suggested by the dark-photon interpretation of the muon (g−2)μ anomaly, as well as a broad range of parameters for the dark-sector models.
Comparison of the two laser sources (UV nanosecond and IR femtosecond) used for the formation of micro-relief at the silicon surface showed the advantage of the second one. A four-level silicon diffractive THz Fresnel lens has been fabricated by laser ablation at high repetition rate (f = 200 kHz) of femtosecond Yb:YAG laser. Features of the lens were investigated in the beam of the Novosibirsk free electron laser at the wavelength of 141 μm. Detailed results of investigation of fabricated lens micro-relief are presented. The measured diffractive efficiency of the lens is in good agreement with the theoretical prediction.
Aim. Evaluation of the possibilities of a new semi-quantitative rapid test for procalcitonin in the diagnosis of multisegmental community-acquired pneumonia.

Materials and methods. A one-stage comparative study involved 123 patients hospitalized in a hospital with a confirmed diagnosis of community-acquired pneumonia. The mean age of the patients was 49.521.0 (MSD) years. On the first day of hospitalization, all patients underwent a general clinical examination, chest x-ray, and a plasma procalcitonin level was determined using a semi-quantitative rapid test.

Results. Indicators of a new semi-quantitative rapid test for procalcitonin of at least 2 ng/ml are directly related to laboratory and instrumental indicators reflecting the severity of community-acquired pneumonia, namely, the severity of respiratory failure (p=0.001), respiratory rate (p=0.001), and heart rate contractions (p=0.001), systolic blood pressure (p=0.025), oxygen saturation (p=0,001), erythrocyte sedimentation rate (p=0.021), fibrinogen (p=0.003) and high CRB-65 scores (p=0.001). They are also associated with multisegmental community-acquired pneumonia (2=4.7; p=0.030) and complications of this disease, such as hydrothorax (p=0.029) and death (2=22.1; p=0.001). Conclusion. Using a new semi-quantitative rapid test for procalcitonin allows you to optimize the diagnosis of complications of community-acquired pneumonia and determine the high risk of multisegmental pneumonia.
Antisense transcription is an important mechanism of gene expression regulation. Antisense RNAs play a role in mRNA processing, translation and epigenetic modifications of DNA and histones in the locus of their origin, leading to gene silencing. HTT is a widely expressed gene, the mutation of which causes Huntington’s disease. The product of the gene plays an important role in many cell processes, such as intracellular trafficking, cell division, autophagy, and others. An antisense transcription has been found at the HTT 5’-region. The HTT-AS gene has been reported to affect HTT expression in a Dicer-dependent manner. In this study, we analyzed extensive data from RNA-seq experiments for antisense transcription at the HTT locus. Antisense transcripts corresponding to the HTT-AS gene were not found. However, we revealed a number of antisense transcripts in different parts of the locus that may take part in the regulation and functioning of the HTT gene. Keywords: antisense transcription, HTT-AS, HTTregulation, Huntington’s disease
In 1992In -2000, new e + e -→ hadrons data were collected in the energy range 0.36 < √ s < 1.4 GeV with the CMD-2 and SND detectors at the VEPP-2M collider in Novosibirsk.The status of the R(s) measurement by the CMD-2 group is presented.
In this work the authors demonstrate efficiency of thin water film, shear driven by gas flow in the mini-channel with local heater.

The effect of microgrooves on heating surface is demonstrated.

It is shown that microgrooves on the heating surface can provide an increase in the critical heat flux due to the capillary effect of microgrooves.
Generalized Hidden Local Symmetry (GHLS) model is the chiral model of pseudoscalar, vector, and axial vector mesons and their interactions. It contains also the couplings of strongly interacting particles with electroweak gauge bosons. Here, GHLS model is confronted with the ALEPH data on the decay $\tau^-\to\pi^-\pi^-\pi^+\nu_\tau$. It is shown that the invariant mass spectrum of final pions in this decay calculated in GHLS framework with the single $a_1(1260)$ resonance disagrees with the experimental data at any reasonable number of free GHLS parameters. Two modifications of GHLS model based on inclusion of two additional heavier axial vector mesons are studied. One of them giving a good description of the ALEPH data, with all the parameters kept free is shown to result in very large $\Gamma_{a_1^\pm\to\pi^\pm\gamma}$ partial width. The other scheme with the GHLS parameters fixed in a way that the universality is preserved and the observed central value of $\Gamma_{a_1^\pm\to\pi^\pm\gamma}$ is reached, results in a good description of the three pion spectrum in $\tau^-\to\pi^+\pi^-\pi^-\nu_\tau$ decay.
In aqueous solution, cyclodextrins (CDs) are able to bind strongly either hydrophobic species or also hydrophilic molecules such as octahedral hexametallic cluster. Systematic investigation of the reactivity between native CDs (α- or β-CD) and water-soluble rhenium clusters [Re6Q8(CN)6]4– with Q = S, Se, and Te were performed, leading to six new crystal structures revealing different types of supramolecular arrangements. Encapsulation of [Re6Q8(CN)6]4– (Q = S, Se, or Te) within two β-CDs is observed regardless of the cluster size. Interestingly, different assembling scenarios are pointed out depending on the host–guest matching featured by no, partial, or deep inclusion complexes that involved either primary or secondary rim of the CD tori. In the specific case of α-CD, only the smaller cluster [Re6S8(CN)6]4– is able to form inclusion complex with the tori host. Solution investigations, using a set of complementary techniques including isothermal titration calorimetry, multinuclear NMR methods, cyclic voltammetry, and electrospray ionization mass spectrometry, corroborate nicely conclusions of the solid-state studies. It appears clearly that size-matching supported by solvent effects play key roles in the stability of the host–guest complexes. At last, circular dichroism studies underline that the chirality induction from cyclodextrins to the rhenium cluster depends strongly on the strength of host–guest interactions.