Hengzongshu/ArticleAgent huggingface dataset:
Experiments were carried out on recombinant B6.CBA-D13Mit76C (B6-M76C) and B6.CBA-D13Mit76B (B6-M76B) mouse lines created by transferring a 102.73-118.83 Mbp fragment of chromosome 13, containing the 5-HT1A receptor gene, from CBA or C57BL/6 strains to a C57BL/6 genetic background, correspondingly. We have recently shown different levels of 5-HT1A receptor functionality in these mouse lines.

The administration of BDNF (300 ng/mouse, i.c.v.) increased the levels of exploratory activity and intermale aggression only in B6-M76B mice, without affecting depressive-like behavior in both lines. In B6-M76B mice the behavioral alterations were accompanied by a decrease in the 5-HT2A receptor functional activity and the augmentation of levels of serotonin and its main metabolite, 5-HIAA (5-hydroxyindoleacetic acid), in the midbrain. Moreover, the levels of dopamine and its main metabolites, HVA (homovanillic acid) and DOPAC (3,4-dihydroxyphenylacetic acid), were also elevated in the striatum of B6-M76B mice after BDNF treatment. In B6-M76C mice, central BDNF administration led only to a reduction in the functional activity of the 5-HT1A receptor and a rise in DOPAC levels in the midbrain.

The obtained data suggest the importance of the 102.73-118.83 Mbp fragment of mouse chromosome 13, which contains the 5-HT1A receptor gene, for BDNF-induced alterations in behavior and the brain monoamine system.
Human apurinic/apyrimidinic (AP)-endonuclease APE1 is one of the key enzymes taking part in the repair of damage to DNA. The primary role of APE1 is the initiation of the repair of AP-sites by catalyzing the hydrolytic incision of the phosphodiester bond immediately 5' to the damage. In addition to the AP-endonuclease activity, APE1 possesses 3'-5' exonuclease activity, which presumably is responsible for cleaning up nonconventional 3' ends that were generated as a result of DNA damage or as transition intermediates in DNA repair pathways.

In this study, the kinetic mechanism of 3'-end nucleotide removal in the 3'-5' exonuclease process catalyzed by APE1 was investigated under pre-steady-state conditions. DNA substrates were duplexes of deoxyribonucleotides with one 5' dangling end and it contained a fluorescent 2-aminopurine residue at the 1st, 2nd, 4th, or 6th position from the 3' end of the short oligonucleotide. The impact of the 3'-end nucleotide, which contained mismatched, undamaged bases or modified bases as well as an abasic site or phosphate group, on the efficiency of 3'-5' exonuclease activity was determined.

Kinetic data revealed that the rate-limiting step of 3' nucleotide removal by APE1 in the 3'-5' exonuclease process is the release of the detached nucleotide from the enzyme's active site.
The results of the flow investigation at the supersonic combustor entrance at tests in the regime of an attached pipe-line are presented. As a source of working gas, a discharge pre-chamber of an impulse wind tunnel was used. The three-dimensional numerical simulation was performed using the software package ANSYS Fluent from the nozzle critical section to the combustor entrance with experimental initial data. The experiments were carried out with the following airflow parameters: M = 4, total pressure P0 = 5.7÷2.0 MPa and total temperature T0=1750÷1200 K. Air flow characteristics and their distribution at the combustor entrance were obtained. It is established that the Mach number field non-uniformity in the flow core at the combustor entrance is 2.3% with a maximum thickness of the boundary layer of 10.7 mm. A good agreement between the calculated and experimental data was obtained.
Development of modern intelligent monitoring and control systems in energy, allowing reducing the level of harmful emissions and energy intensity production is relevant. In the scientific literature usage of new efficient machine learning techniques for automatic extraction of features for the classification of combustion regimes is insufficiently covered. In this paper we describe a method for determining combustion regimes based on images of flames. To determine the combustion regimes, a convolutional neural network is trained using labeled data. It is shown that in the gas flame colour images the accuracy of the classification of regimes is up to 98%. Results of the convolutional neural network are compared to classification results of various linear models.
We experimentally demonstrate that Kerr spatial self-cleaning of a pulsed beam can be obtained in an amplifying multimode optical fiber. An input peak power of 500 W only was sufficient to produce a quasi-single-mode emission from the double-clad ytterbium doped multimode fiber (YMMF) with non-parabolic refractive index profile. We compare the self-cleaning behavior observed in the same fiber with loss and with gain. Laser gain introduces new opportunities to achieve spatial self-cleaning of light in multimode fibers at a relatively low power threshold.
Increasing amounts of data support a role for guanine quadruplex (G4) DNA and RNA structures in various cellular processes. We stained different organisms with monoclonal antibody 1H6 specific for G4 DNA. Strikingly, immuno-electron microscopy showed exquisite specificity for heterochromatin. Polytene chromosomes from Drosophila salivary glands showed bands that co-localized with heterochromatin proteins HP1 and the SNF2 domain-containing protein SUUR. Staining was retained in SUUR knock-out mutants but lost upon overexpression of SUUR. Somatic cells in Macrostomum lignano were strongly labeled, but pluripotent stem cells labeled weakly. Similarly, germline stem cells in Drosophila ovaries were weakly labeled compared to most other cells. The unexpected presence of G4 structures in heterochromatin and the difference in G4 staining between somatic cells and stem cells with germline DNA in ciliates, flatworms, flies and mammals point to a conserved role for G4 structures in nuclear organization and cellular differentiation.
The gasification of Russian regions is one of the most important problems for the national economy. The development of the gas supply system contributes to the socio-economic development of the regional economy, to the increase increasing the level and quality of life, and to the solution of the key environmental issues. The Krasnoyarskiy Kray is the only region in the east of the country that has a significant resource potential of natural gas but at the same time, it can’t be connected to the trunk gas pipeline in the short and long term perspective.

The purpose of the study is to assess the efficiency of investments in the construction of gas supply facilities, gasification, and their exploitation in the southern and central regions of the Krasnoyarskiy Kray. In this study authors solved the following objectives: we systematized information about the current state of the Krasnoyarskiy Kray gasification and the prerequisites for its development (resource base and transport infrastructure); we assessed economic efficiency of the investments in the construction, gasification, and exploitation of gas supply facilities in the southern and central regions of the Krasnoyarskiy Kray; we formulated proposals to ensure economic efficiency using the mechanism of public-private partnership.

The authors recommend an option according to which federal budget investments will amount to 70% of their total investment in the Krasnoyarskiy Kray gasification program. Under this option, the selling price of gas will drop to 4708 rubles per 1000 cubic meters of natural gas excluding VAT. Organization of production, preparation for transport, and transportation of natural gas in the central regions of the Krasnoyarskiy Kray will create new highly paid jobs, significantly increase the GRP, and improve the demographic situation.
The study was dedicated to investigation of some hemostasis and endothelial dysfunction factors association with probability of presence of vulnerable atherosclerotic plaques in coronary arteries in men with atherosclerosis. The blood levels of factor VII, factor XII and MCP-1 were higher, and concentration of sVCAM-1 lower in men with vulnerable atherosclerotic plaques in the coronary arteries, compared to men who had stable plaques. Have been revealed correlation links between the blood levels of factor II, factor XII, MCP-1 and the presence of vulnerable atherosclerotic plaques in the coronary arteries. Results of logistic regression analysis showed that the relative risk of present of vulnerable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII and MCP-1.
Synchrotron radiation facilities are no longer 'exotic' experimental tools for many researchers. A network of synchrotrons already covers Europe, North and South Americas, Asian countries and is widely used by a highly international scientific community. Construction of new synchrotrons in other geographical regions is planned.

In particular, three new synchrotrons are planned to be constructed and subsequently used in Russia, including the one of the three (SKIF) to be located in Novosibirsk region.

One of the problems related to constructing the synchrotrons in new regions is to educate a broad enough research community, so that sufficient number of efficient users of these facilities appears, who can submit highlevel proposals which are adequate to the level of the unique instruments, perform experiments, process and interpret data. Not only technical support engineers, but also beamline scientists and educated users are needed.
A primordial magnetic field with strength in the 1–10 pG range can resolve the tension between different measurements of the Hubble constant and provide an explanation for the excess opacity in the 21 cm line at redshift 15 < z < 20 if it is present during the recombination and reionization epochs. This field can also survive in the voids of the large-scale structure in the present day universe. We study the sensitivity reach of the gamma-ray technique for measurement of such a relatively strong cosmological magnetic field using deep exposure(s) of the nearest hard spectrum blazar(s) with CTA telescopes. We show that the gamma-ray measurement method can sense the primordial magnetic field with a strength of up to 10 −11 G. Combination of the cosmic microwave background and gamma-ray constraints can thus sense the full range of possible cosmological magnetic fields to confirm or rule out their relevance to the problem of the origin of cosmic magnetic fields, as well as their influence on recombination and reionization epochs.
Objectives The effects of atorvastatin on the atherogenic and anti-atherogenic lipoprotein-cholesterol (C-LP) and lipoprotein-triglyceride (TG-LP) fractions and subfractions at the early stage of murine acute hyperlipidaemia, and its pleiotropic anti-inflammatory effects via the activity of matrix metalloproteinases (MMPs) were studied. Methods Atorvastatin (75 mg/kg) was administered to ICR mice with acute lipaemia induced by a single injection of Triton WR 1339 (500 mg/kg). A novel small-angle X-ray scattering (SAXS) method was used for the determination of the fractional and subfractional composition of C-LP and TG-LP. Key finding In Triton WR 1339-treated mice, there was a drastic increase in the atherogenic low-density C-LP (C-LDL) fraction, intermediate density lipoprotein-cholesterol (C-IDL) subfraction, and very low-density C-LP (C-VLDL) fractions (C-VLDL3–5 subfraction). Additionally, there was an increase in the C-HDL3 subfraction. Treatment of lipaemia with atorvastatin resulted in the normalization of the atherogenic C-LDL fraction and the C-IDL subfraction. A decrease in C-VLDL (C-VLDL3–5 subfraction), total cholesterol and, especially, triglyceride (TG) concentrations was also demonstrated. Similar results were obtained with the TG-LP fractions and subfractions. Additionally, atorvastatin treatment resulted in an increase in the serum and liver MMP activity. Conclusion High-dose atorvastatin therapy exerts its rapid lipid-lowering and pleiotropic effect(s) in the early stages of acute lipaemia induced with Triton WR-1339.
We present the numerical study of the statistical properties of the partially coherent quasi-CW high-Q cavity Raman fiber laser. The statistical properties are different for the radiation generated at the spectrum center or spectral wings.

It is found that rare extreme events are generated at the far spectral wings at one pass only. The mechanism of the extreme events generation is a turbulent-like four-wave mixing of numerous longitudinal generation modes.

The similar mechanism of extreme waves appearance during the laser generation could be important in other types of fiber lasers.
We consider a single machine, a set of unit-time jobs, and a set of unit-time errors. We assume that the time-slot at which each error will occur is not known in advance but, for every error, there exists an uncertainty area during which the error will take place. In order to find if the error occurs in a specific time-slot, it is necessary to issue a query to it. In this work, we study two problems: (i) the error-query scheduling problem, whose aim is to reveal enough error-free slots with the minimum number of queries, and (ii) the lexicographic error-query scheduling problem where we seek the earliest error-free slots with the minimum number of queries. We consider both the off-line and the on-line versions of the above problems. In the former, the whole instance and its characteristics are known in advance and we give a polynomial-time algorithm for the error-query scheduling problem. In the latter, the adversary has the power to decide, in an on-line way, the time-slot of appearance for each error. We propose then both lower bounds and algorithms whose competitive ratios asymptotically match these lower bounds.
Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here.

New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-O-benzoyl-d-ribofuranose and 5-substituted uracil moieties and have half-maximal inhibitory concentrations (IC50) in the lower micromolar and submicromolar range. 2′,3′,5′-Tri-O-benzoyl-5-iodouridine manifested the strongest inhibitory effect on Tdp1 (IC50 = 0.6 μM). A decrease in the number of benzoic acid residues led to a marked decline in the inhibitory activity, and pyrimidine nucleosides lacking lipophilic groups (uridine, 5-fluorouridine, 5-chlorouridine, 5-bromouridine, 5-iodouridine, and ribothymidine) did not cause noticeable inhibition of Tdp1 (IC50 > 50 μM). No PARP1/2 inhibitors were found among the studied compounds (residual activity in the presence of 1 mM substances was 50–100%).

Several O-benzoylated uridine and cytidine derivatives strengthened the action of topotecan on HeLa cervical cancer cells.
We study the processes $\gamma \gamma \to \eta_c \to \eta' K^+ K^-$, $\eta' \pi^+ \pi^-$, and $\eta \pi^+ \pi^-$ using a data sample of 519 $fb^{-1}$ recorded with the BaBar detector operating at the SLAC PEP-II asymmetric-energy $e^+e^-$ collider at center-of-mass energies at and near the $\Upsilon(nS)$ ($n = 2,3,4$) resonances. This is the first observation of the decay $\eta_c \to \eta' K^+ K^-$ and we measure the branching fraction $\Gamma(\eta_c \to \eta' K^+ K^-)/(\Gamma(\eta_c \to \eta' \pi^+ \pi^-)=0.644\pm 0.039_{\rm stat}\pm 0.032_{\rm sys}$. Significant interference is observed between $\gamma \gamma \to \eta_c\to \eta \pi^+ \pi^-$ and the non-resonant two-photon process $\gamma \gamma \to \eta \pi^+ \pi^-$. A Dalitz plot analysis is performed of $\eta_c$ decays to $\eta' K^+ K^-$, $\eta' \pi^+ \pi^-$, and $\eta \pi^+ \pi^-$. Combined with our previous analysis of $\eta_c \to K \bar K \pi$, we measure the $K^*_0(1430)$ parameters and the ratio between its $\eta' K$ and $\pi K$ couplings. The decay $\eta_c \to \eta' \pi^+ \pi^-$ is dominated by the $f_0(2100)$ resonance, also observed in $J/\psi$ radiative decays. A new $a_0(1700) \to \eta \pi$ resonance is observed in the $\eta_c \to \eta \pi^+ \pi^-$ channel. We also compare $\eta_c$ decays to $\eta$ and $\eta'$ final states in association with scalar mesons as they relate to the identification of the scalar glueball.
The research results of processes proceeding in supersonic jets of light hydrocarbons, activated by an electron beam are presented.

It is shown, that condensation suppressed at activation by electrons in the initial stage of condensation.

The developed condensation conditions mode leads to increasing of a part of heavy corpuscles in activated stream and not only owing to stimulation of condensation but because of formation of heavy hydrocarbonic molecules.
Background Rheumatoid arthritis (RA) is associated with early progression of cardiovascular (CV) diseases. The CV risk calculators had been verified on a specific population1 and should be applied predominantly for them. Systematic COronary Risk Evaluation (SCORE) was recommended by EULAR for use in RA patients with multiplying coefficient 1,5.2 Nevertheless, SCORE don't consider RA-specific factors and couldn't be used in young patient. For timely prevention additional criteria is needed to evaluate CV risk in RA-patents. A presence of atherosclerotic plaque (APl) or intima-media thickening, assessed by carotid ultrasonography, may be used as a high CV risk marker after adjustment by age and sex factors.

Methods One hundred forty eight Caucasian patients with RA (age – 53 years;40; 60 DAS28 5.01 [3.91; 5.90]) without (APl) were included in our study. Patients had ACR-defined RA (1987 classification criteria). All patients gave written informed consent before enrollment. SCORE with multiplying coefficient 1.5 was used for the CV risk determining. Range of atherosclerotic progression was assessed by ultrasonography with measurement of carotid intima-media thickness (IMT). IMT measured had been compared with ranges followed:<35/35–44/45–54/55–64/65–74/>75 age – 0,55/0,72/0,72/0,80/0,86/1,0 mm for the right artery and 0,53/0,65/0,73/0,85/0,89/1,0 mm for the left one (men); 0,47/0,51/0,71/0,78/0,87/0,87/0,87 mm for the right artery and 0,50/0,55/0,71/0,80/0,91/0,98 for the left one (women), respectively.3 Descriptive statistics, Chi-squared test, Spearman rank correlation coefficient were used for data analysis. Results are presented as median and 25th/75th percentiles (Me [25th percentile; 75th percentile].

Conclusions Using age- and sex-specific criteria for the IMT evaluation may be useful in young patients with RA.
The purpose of this paper is to develop further the main concepts of Phenomena Dynamic Logic (P-DL) and Cognitive Dynamic Logic (C-DL), presented in the previous paper. The specific character of these logics is in matching vagueness or fuzziness of similarity measures to the uncertainty of models. These logics are based on the following fundamental notions: generality relation, uncertainty relation, simplicity relation, similarity maximization problem with empirical content and enhancement (learning) operator. We develop these notions in terms of logic and probability and developed a Probabilistic Dynamic Logic of Phenomena and Cognition (P-DL-PC) that relates to the scope of probabilistic models of brain. In our research the effectiveness of suggested formalization is demonstrated by approximation of the expert model of breast cancer diagnostic decisions. The P-DL-PC logic was previously successfully applied to solving many practical tasks and also for modelling of some cognitive processes.
In the paper the ignition delay times of hydrogen-silane-air mixtures at low pressures from 0.4 atm to 1 atm and mixture temperatures from 300 K to 900 K using the detailed kinetic mechanisms were calculated.

It was shown that dependencies of ignition delay time on temperature are non-monotonic. In these dependences a region of "negative temperature coefficient" is presented. The effect of the mixture pressure and the silane concentration in the mixture on the length of this region was revealed.

It was shown that the increasing of the silane concentration in the mixture, as well as the increasing the mixture pressure, leads to increasing of the "negative temperature coefficient" region length.
The main application area for GaSe crystals is nonlinear optics, but there are problems with machining and antireflection coatings due to the layered structure of GaSe. Large GaSe crystals with dominant ε-modification were grown. Using various harmonics of a femtosecond laser, antireflection microstructures (ARM) were fabricated by laser ablation on the plate surface and modes providing increased transmission up to 90% in the mid-IR were selected. Using SEM and optical microscopy, as well as EDX and optical spectroscopy, defects on the GaSe surface and their effect on the spectral region and the degree of transmission increase were studied.
The Department of Semiconductor Physics at the Faculty of Physics, Novosibirsk State University, trains specialists for research work in the field of condensed matter physics, semiconductor physics and the physics of low-dimensional systems and nanostructures. It also provides knowledge enabling its graduates to participate in developing semiconductor technologies, improving existing and creating new opto-, micro- and nanoelectronic devices.

The article describes the history of the creation of the department, the main stages of the formation of training courses and work on the organization of students’ research practice in the laboratories of Rzhanov Institute of Semiconductor Physics (ISP), which is the basic Institute for the department. An overview of the training courses taught at the department for the preparation of bachelors and masters is given.

It is told about the scientific and technological achievements of ISP, and about unique measuring, analytical and technological equipment available in the laboratories of the Institute, which is the basis for organizing research work of students at a high scientific and methodological level.
A problem on generation of unsteady nonlinear waves on the surface of an infinitely deep ideal fluid due to the motion of a submerged elliptical cylinder is considered. It is supposed that the cylinder can rotate in addition to translational two-dimensional motion.

The initial formulation of the problem is reduced to an integrodifferential system of equations for the functions defining the free surface shape, the normal and tangential components of velocity on the free boundary.

The small-time asymptotics of the solution is constructed in the case of the cylinder that moves with a constant acceleration from rest.
In this work, we propose a concept of a coupled fiber laser exhibiting PT-symmetry properties. We consider a system operated via Raman gain. The scheme comprises two identical fiber loops (ring cavities) connected by means of two fiber couplers with variable phase shift between them. We show that by changing the phase shift one can switch between generation regimes, realizing either PT-symmetric or PT-broken solution. Furthermore, the paper investigates some peculiarities of the system such as power oscillations and the role of nonlinear phase shift in fiber rings.
Powerful femtosecond laser pulses that propagate through narrow ablating capillaries cause modification of capillary walls

which is studied experimentally and theoretically. At low intensities, laser-induced periodic surface structures (LIPSS) and porous coating composed of sub-micron particles appear on the walls. At higher intensities, the surface is covered by deposited droplets of the size up to 10 $μ$m. In both cases, the ablated material forms a solid plug that completely blocks the capillary after several hundreds or thousands of pulses.

The suggested theoretical model indicates that plug formation is a universal effect. It must take place in any narrow tube subject to ablation under the action of short laser pulses.