Hengzongshu/ArticleAgent huggingface dataset:
Methods for prioritizing or ranking candidate genes according to their importance based on specific criteria via the analysis of gene networks are widely used in biomedicine to search for genes associated with diseases and to predict biomarkers, pharmacological targets and other clinically relevant molecules. These methods have also been used in other fields, particularly in crop production. This is largely due to the development of technologies to solve problems in marker-oriented and genomic selection, which requires knowledge of the molecular genetic mechanisms underlying the formation of agriculturally valuable traits.

A new direction for the study of molecular genetic mechanisms is the prioritization of biological processes based on the analysis of associative gene networks. Associative gene networks are heterogeneous networks whose vertices can depict both molecular genetic objects (genes, proteins, metabolites, etc.) and the higher-level factors (biological processes, diseases, external environmental factors, etc.) related to regulatory, physicochemical or associative interactions. Using a previously developed method, biological processes involved in plant responses to increased cadmium content, saline stress and drought conditions were prioritized according to their degree of connection with the gene networks in the SOLANUM TUBEROSUM knowledge base.

The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. On the other hand, a group of processes related to the development of seeds was revealed to be drought specific, while processes associated with ion transport were included in the list of responses specific to salt stress and processes associated with the metabolism of lipids were found to be involved specifically in the response to cadmium.
Mixed nanocrystalline Ce-Zr-O oxides (Ce/Zr = 1 or 7/3) were prepared by modified Pechini route using ethylene glycol solutions of metal salts.

Detailed characterization of their real structure and surface properties by X-ray diffraction on synchrotron radiation with the full-profile Rietveld analysis, high resolution electron microscopy with elemental analysis, Raman spectroscopy, UV-Vis and X-ray photoelectron spectroscopy revealed a high homogeneity of cations distribution in nanodomains resulting in stabilization of disordered cubic phase.

This provides a high dispersion of NiO loaded on these mixed oxides by wet impregnation, a high reactivity and mobility of oxygen in these catalysts and strong interaction of Ni with support in the reduced state. This helps to achieve a high activity and coking stability of developed catalysts in CH4 dry reforming in feeds with CH4 concentration up to 15% and CH4/CO2 ratio =1.
Disclaimer 2019: The EACTS/EACTA/EBCP Guidelines represent the views of the EACTS, the EACTA and EBCP and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their dating. The EACTS, EACTA and EBCP are not responsible in the event of any contradiction, discrepancy and/or ambiguity between the EACTS, EACTA and EBCP Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the EACTS, EACTA and EBCP Guidelines fully into account when exercising their clinical judgement as well as in the determination and the implementation of preventive, diagnostic or therapeutic medical strategies; however, the EACTS, EACTA and EBCP Guidelines do not, in any way whatsoever, override the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and, where appropriate and/or necessary, in consultation with that patient and the patient’s care provider. Nor do the EACTS, EACTA and EBCP Guidelines exempt health professionals from giving full and careful consideration to the relevant official, updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription. The article has been co-published with permission in the British Journal of Anaesthesia, the European Journal of Cardio-Thoracic Surgery and the Interactive CardioVascular and Thoracic Surgery.
Monitoring studies were carried out according to generally accepted methods in the northern forest-steppe of West Siberia in 2019–2020, using the varieties collection of the Institute of Cytology and Genetics SB RAS. Studies have shown that the genotypes of spring wheat varieties had a significant impact on the functioning of the “plant-phytopathogensaprotrophs” system. The parasitic activity of phytopathogens (Bipolaris sorokiniana Sacc. Shoem., Fusarium spp. Link.) differed in the varietal groups to 43.6 %. Varieties of Asian origin (China, India, Kazakhstan, Syria) were most affected by the root infections, Australian varieties were least affected by phytopathogens, due to the chemical composition of root exudates, which suppressed the number of parasitic and saprotrophic microorganisms. Varietal secretions of the wheat plants roots regulated the number of saprotrophic rhizospheric microorganisms. The share of the influence of the “variety” factor on the number of saprotrophic soil microorganisms was 24.3 % and was reliable at a 1 % level. The most sensitive to the composition and number of root exudates of wheat plants turned out to be bacteria of various trophic groups, the most resistant were micromycetes. In comparison with the background indices of non-rhizospheric soil, the number of cellulosolytic bacteria increased up to 3 times (West European varieties), bacteria consuming organic nitrogen – up to 5.6 times (Asian varieties), consumers of organic nitrogen forms – up to 2.9 times (West European varieties), oligonitrophilic bacteria – up to 12.7 times (Siberian varieties). Varieties far from the region of the study (Australia, Africa, America) exerted a repressive effect on the trophic groups of microorganisms, reducing their number in comparison with indicators of non-rhizospheric soil.
This paper is a survey of some results about the structure of periodic groups saturated with finite simple groups of Lie type.

It is based on a talk of authors given on the XI workshop on Group theory dedicated to the 70-th anniversary of A.
The energy response of the ATLAS calorimeter is measured for single charged pions with transverse momentum in the range $10

Charged pions originating from $\tau$-lepton decays are used to provide a sample of high-$p_\textrm{T}$ isolated particles, where the composition is known, to test an energy regime that has not previously been probed by in situ single-particle measurements. To investigate the source of the discrepancies, the width of the distribution of the ratio of calorimeter energy to track momentum, the energies per layer and response in the hadronic calorimeter are also compared between data and simulation.

The calorimeter response to single-pions is observed to be overestimated by ${\sim}2\%$ across a large part of the $p_{\textrm{T}}$ spectrum in the central region and underestimated by ${\sim}4\%$ in the endcaps in the ATLAS simulation. The uncertainties in the measurements are ${\lesssim}1\%$ for $15
The lifetime of the τ lepton is measured using the process e+e−→τ+τ−, where both τ leptons decay to 3πντ. The result for the mean lifetime, based on 711 fb−1 of data collected with the Belle detector at the Υ(4S) resonance and 60 MeV below, is τ=(290.17±0.53(stat)±0.33(syst))×10−15 s. The first measurement of the lifetime difference between τ+ and τ− is performed. The upper limit on the relative lifetime difference between positive and negative τ leptons is |Δτ|/τ<7.0×10−3 at 90% C.L.Received 1 November 2013DOI:https://doi.org/10.1103/PhysRevLett.112.031801© 2014 American Physical Society
The formation of reversible switchable nanostructures monitored by solution and solid‐state methods is still a challenge in supramolecular chemistry.

By a comprehensive solid state and solution study we demonstrate the potential of the fivefold symmetrical building block of pentaphosphaferrocene in combination with Cu I halides to switch between spheres of different porosity and shape. With increasing amount of CuX, the structures of the formed supramolecules change from incomplete to complete spherically shaped fullerene‐like assemblies possessing an I h ‐C 80 topology at one side and to a tetrahedral‐structured aggregate at the other.

In the solid state, the formed nano‐sized aggregates reach an outer diameter of 3.14 and 3.56 nm, respectively. This feature is used to reversibly encapsulate and release guest molecules in solution.
We study the evolution of thick domain walls in the expanding universe. We have found that the domain wall evolution crucially depends on the time-dependent parameter C ( t ) = 1/( H ( t ) δ 0 ) 2 , where H ( t ) is the Hubble parameter and δ 0 is the width of the wall in flat space-time. For C ( t ) > 2 the physical width of the wall, a ( t ) δ ( t ), tends with time to constant value δ 0 , which is microscopically small. Otherwise, when C ( t ) ≤ 2, the wall steadily expands and can grow up to a cosmologically large size.
We test the predictions of the theory of weak wave turbulence by performing numerical simulations of the Gross-Pitaevskii equation (GPE) and the associated wave-kinetic equation (WKE).

We consider an initial state localized in Fourier space, and we confront the solutions of the WKE obtained numerically with GPE data for both the wave-action spectrum and the probability density functions (PDFs) of the Fourier mode intensities.

We find that the temporal evolution of the GPE data is accurately predicted by the WKE, with no adjustable parameters, for about two nonlinear kinetic times. Qualitative agreement between the GPE and the WKE persists also for longer times with some quantitative deviations that may be attributed to the combination of a breakdown of the theoretical assumptions underlying the WKE as well as numerical issues. Furthermore, we study how the wave statistics evolves toward Gaussianity in a timescale of the order of the kinetic time. The excellent agreement between direct numerical simulations of the GPE and the WKE provides a solid foundation to the theory of weak wave turbulence.
This work presents new experimental data on the evolution of two-dimensional (2D) ordered arrays of microdroplets levitating over a heated liquid surface. It was found that the average distance between the centers of the droplets in the array increases with the droplet diameter, being practically independent of the number of droplets in the array and substrate temperature. Dimensionless correlation ratios for the distance between the droplets were obtained, which can be used to verify the theoretical models under development.
We develop a new mathematical model for rotational sedimentation of particles for steady flows of a viscoplastic granular fluid in a concentric-cylinder Couette geometry when rotation of the Couette cell inner cylinder is prescribed.

We treat the suspension as a micro-polar fluid. The model is validated by comparison with known data of measurement.

Within the proposed theory, we prove that sedimentation occurs due to particles' rotation and rotational diffusion.
The catalyst systems (FI)TiCl3/MAO (FI = phenoxyimine ligand with an additional aryl–O–CH3 donor) display exceptionally high activity in selective ethylene trimerization. By means of NMR and EPR spectroscopy, the nature of the Ti species formed in the catalyst systems (FI)TiCl3/MAO, (FI)TiCl3/MMAO, and (FI)TiCl3/AlR3/[Ph3C]+[B(C6F5)4]− (R = Me, Et, iBu) has been studied. It was shown that outer-sphere ion pairs of the type [(FI)TiIVMe2]+[A]− ([A]− = [MeMAO]−, [MeMMAO]−, [B(C6F5)4]−) are formed at the initial stage of the reaction of (FI)TiCl3 with MAO, MMAO, and AlMe3/[Ph3C]+[B(C6F5)4]−. These ion pairs further partially convert into TiIII and TiII species. In the systems (FI)TiCl3/MAO and (FI)TiCl3/AlMe3/[Ph3C]+[B(C6F5)4]−, complexes with the proposed structures (FI)TiIIIMe2, (FI)TiIICl, and [(FI)TiII(S)]+[A]− ([A]− = [MeMAO]−, [B(C6F5)4)]−, S = solvent, vacancy) were observed (concentrations of TiIII species was lower than those of the TiII congeners). In contrast, in the system (FI)TiCl3/MMAO, the concentrations of TiIII species (ion pairs of the type [(FI)TiIII(μ-H)(μ-Cl)AliBu2]+[MeMMAO]−) were higher than those of the TiII counterparts (ion pairs [(FI)TiII(S)]+[MeMMAO]−). The system (FI)TiCl3/MMAO displays lower activity and selectivity in 1-hexene formation, in comparison to (FI)TiCl3/MAO, due to undesirable PE generation. Probably, TiII and TiIV ion pairs are those participating in ethylene trimerization.
We report the analysis of the three-body e^{+}e^{-}→BB[over ¯]π^{±}, BB[over ¯]^{*}π^{±}, and B^{*}B[over ¯]^{*}π^{±} processes, including the first observations of the Z_{b}^{±}(10610)→[BB[over ¯]^{*}+c.c.]^{±} and Z_{b}^{±}(10650)→[B^{*}B[over ¯]^{*}]^{±} transitions that are found to dominate the corresponding final states. We measure Born cross sections for the three-body production of σ(e^{+}e^{-}→[BB[over ¯]^{*}+c.c.]^{±}π^{∓})=[17.4±1.6(stat)±1.9(syst)] pb and σ(e^{+}e^{-}→[B^{*}B[over ¯]^{*}]^{±}π^{∓})=[8.75±1.15(stat)±1.04(syst)] pb and set a 90% C.L. upper limit of σ(e^{+}e^{-}→[BB[over ¯]]^{±}π^{∓})<2.9 pb. The results are based on a 121.4 fb^{-1} data sample collected with the Belle detector at a center-of-mass energy near the ϒ(10860) peak.
An efficient and operationally simple synthesis of 7-deuteropyrazolo[1,5-a]pyridine and 7-deutero-1,2,4-triazolo[1,5-a]pyridine derivatives using α-H/D exchange of 1-aminopyridinium cations in basic D2O followed by a 1,3-cycloaddition of acetylenes and nitriles is presented.

A high regioselectivity and a high degree of deuterium incorporation were achieved. The procedure was applied for several 4-R-1-aminopyridinium cations (R = H, Me, OMe).
We investigate and compare soliton turbulence appearing as a result of modulational instability of the homogeneous wave train in three nonlinear models for surface gravity waves

the nonlinear Schrödinger equation, the super compact Zakharov equation, and the fully nonlinear equations written in conformal variables. We show that even at a low level of energy and average wave steepness, the wave dynamics in the nonlinear Schrödinger equation fundamentally differ from the dynamics in more accurate models. We study energy losses of wind waves due to their breaking for large values of total energy in the super compact Zakharov equation and in the exact equations

and show that in both models, the wave system loses 50% of energy very slowly, during few days.
The relation between Russia’s macroeconomic growth and its regional components for the period of 1990–2013 is considered in the paper. The hypothesis is that the increase in regional disparities within the post-Soviet period, picked up by standard measures and noted by many authors, is not connected with the systemic removal of regional indicators from each other. The Russian regional space is considered to have specific forms of convergence-divergence, required to be identified.

The dynamics of regional space configuration in Russia is considered from a new point of view—as a distribution of mass (volume) of the gross regional product (GRP) over the growth rates. The estimation and forecast of the structural characteristics of GRP mass distribution are made on the basis of the “distribution dynamics” approach. Using this approach, the forecast of the GRP dynamics and structure until 2025 is made.

The average annual growth rate is expected to be around 104,5 % by 2025, while differentiation of growth rates significantly increases. The phase of macroeconomic growth over the last 15 years is reflected on its regional components: GRP growth in Russia in general, both before and after the crisis of 2009, creates a denser distribution than in 2009. The general trend of the 2000s and subsequent years is characterized by a certain decline in the differentiation of GRP per capita relating to the main regional space of Russia (74 regions). The results of this research may be useful for regional regulation policy purposes. A significant part of the Russian regions in 2009–2013, in spite of the dominant trend, provides dynamics not worse than that of the number of countries with a developed market.
Down-regulator associated protein, DrAp1, acts as a negative cofactor (NC2α) in a transcription repressor complex together with another subunit, down-regulator Dr1 (NC2β).

In binding to promotors and regulating the initiation of transcription of various genes,
The interest in nucleoporins originates from their identification as constituents of nuclear pores. The latter are visible as prominent annuli in the electron microscope (Callan et al., 1949). Comprehensive studies carried out in the 1950s led to these general conclusions: i) all nuclear envelope (NE) have pores, and ii) irrespective of species or cell type, the pore complexes show similarities in shape and size. This very much supported the hypotheses suggesting that these pores might act as transport channels between the nucleus and the cytoplasm of eukaryotic cells. A breakthrough for these ideas was achieved by the combination of microinjection techniques with transmission electron microscopy (TEM). In 1962, Feldherr injected contrasting permeants into the cytoplasm of amebas and observed their path through pores using TEM. Together with the observation of giant polycystronic messengers in transit through nuclear pores (Stevens and Swift, 1966), these experiments determined the direction of further study in the context of nucleocytoplasmic transport.
Solution-grown single crystals of furan/phenylene co-oligomer combine efficient charge transport properties and high fluorescence efficiency.
Uterine bleeding caused by placenta previa is one of the main causes of massive blood loss and death in obstetric practice.Objectives. To analyze the efficacy and safety of various therapeutic strategies to stop uterine bleeding in women in labor and puerperants on the basis of research results.Materials and Methods. Available researches on the diagnosis and treatment of uterine bleeding with placenta previa between 2000 and 2015 were included in the study. The search was carried out in medical databases PubMed and Cochrane Library with free access to the publication.Results. 61 publications were included in the analysis. The basic principles of diagnosis and intensive therapy of uterine bleeding with placenta previa are presented from the position of obstetrician and anaesthesiologist-resuscitator. Particular attention is paid to the analysis of studies evaluating the efficacy and safety of infusion-transfusion therapy in this category of patients. Main indications and contraindications to blood clotting factors and antifibrinolytic agents are shown.Conclusion. The combined use of all available modern methods of stopping uterine bleeding can significantly reduce blood loss and help to improve disease outcomes. The most promising therapy is a targeted assignment of clotting factors concentrates under the control of thromboelastography which indicates the need for further research.
We provide sufficient conditions for stability of a linear structurally heterogeneous economy under heterogeneous learning of agents, extending the results of Honkapohja and Mitra (2006), Kolyuzhnov (2011), and Bogomolova and Kolyuzhnov (2019). Sufficient conditions for stability under heterogeneous mixed RLS/SG learning for four classes of models: models without lags and with lags of the endogenous variable and with t or t-1- dating of expectations, are provided for the cases of the diagonal structure of the shock process behaviour or the heterogeneous RLS learning and are presented in terms of structural heterogeneity and are independent of heterogeneity in learning. The results are based on the negative diagonal dominance approach and are provided, first, in terms of the existence of the weights for aggregation of endogenous variables and of expectations across agents, interrelated in a special way, and then in terms of the E-stability of a suitably defined aggregate economy. The fundamental nature of the approach adopted in the paper allows one to apply its results to a vast majority of the existing and prospective linear and linearized economic models (including estimated DSGE models) with adaptive learning of agents.
Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers. We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.
According to the novel approach to the treatment of patients as persons, the phenomenon of palliation distinguishes modern medicine from the traditional medical paternalism. it means that medical science and practice go beyond physical health, when treatment methods aimed to improving the quality of patient’ life are widely used. man as a phenomenon of culture becomes something much more than his physical body.

The purpose of the study was to analyze the palliative care legislation.

The palliative care was shown not to be a type of medical care, but it refers to the terms used in clinical practice to determine the purposes of specialized treatment aimed at not curing the disease, but rather extending life and controlling symptoms. it is necessary to include patients’ relatives and friends to the number of people in need of medical care. The development of the federal state educational standard of higher education in the specialty of a palliative care physician is also of great importance.