Hengzongshu/ArticleAgent huggingface dataset:
BACKGROUND: Cardiac anesthetics rely heavily on opioids, with the standard patient receiving between 70 and 105 morphine sulfate equivalents (MSE; 10–15 µg/kg of fentanyl). A central tenet of Enhanced Recovery Programs (ERP) is the use of multimodal analgesia. This study was performed to assess the association between nonopioid interventions employed as part of an ERP for cardiac surgery and intraoperative opioid administration. METHODS: This study represents a post hoc secondary analysis of data obtained from an institutional ERP for cardiac surgery. Consecutive patients undergoing cardiac surgery received 5 nonopioid interventions, including preoperative gabapentin and acetaminophen, intraoperative dexmedetomidine and ketamine infusions, and regional analgesia via serratus anterior plane block. The primary objective, the association between intraoperative opioid administration and the number of interventions provided, was assessed via a linear mixed-effects regression model. To assess the association between intraoperative opioid administration and postoperative outcomes, patients were stratified into high (>50 MSE) and low (≤50 MSE) opioids, 1:1 propensity matched based on 15 patients and procedure covariables and assessed for associations with postoperative outcomes of interest. To investigate the impact of further opioid restriction, ultralow (≤25 MSE) opioid participants were then identified, 1:3 propensity matched to high opioid patients, and similarly compared. RESULTS: A total of 451 patients were included in the overall analysis. Analysis of the primary objective revealed that intraoperative opioid administration was inversely related to the number of interventions employed (estimated −7.96 MSE per intervention, 95% confidence interval [CI], −9.82 to −6.10, P < .001). No differences were detected between low (n = 136) and high (n = 136) opioid patients in postoperative complications, postoperative pain scores, time to extubation, or length of stay. No differences were found in outcomes between ultralow (n = 63) and high (n = 132) opioid participants. CONCLUSIONS: Nonopioid interventions employed as part of an ERP for cardiac surgery were associated with a reduction of intraoperative opioid administration. Low and ultralow opioid use was not associated with significant differences in postoperative outcomes. These findings are hypothesis-generating, and future prospective studies are necessary to establish the role of opioid-sparing strategies in the setting of cardiac surgery.
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been allowed to fight for 14 days. This experiment demonstrated increased Th, Dat1 and Snca but not Bdnf mRNA levels in the former group as compared to the controls. In the latter group, the expression of the Th and Dat1 genes was still enhanced, while the level of Snca mRNA did not differ from that in the controls. These findings suggest that positive fighting experience enhances the expression of the genes concerned with dopaminergic systems and this enhanced expression is preserved for a long time afterwards. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels in the winners.
In this paper, the initial stages of local anodic oxidation (LAO) process initiated by AFM probe are studied on the wide (∼100μm) terraces of the atomic-smooth Si (111) surface when creating dense array of local oxidation points. The dependence of LAO points height on the value of voltage initiating the oxidation is found to have a pronounced step-like feature with a characteristic period of 0.7 ± 0.1 nm. The presented analysis shows for the first time the realization of the step-layer mechanism of anodic oxide growth on the Si (111) surface.
The sublithospheric origin of these diamonds is supported by the presence of mineral inclusions corresponding to associations of the transition zone and lower mantle.

The features of morphology and internal structure have been studied by optical and scanning electron microscopy (SEM), cathodoluminescence topography (CL), and electron backscatter diffraction (EBSD) techniques.

Diamonds typically have complicated growth histories displaying alternating episodes of growth, dissolution, and post-growth deformation and crushing processes. Most crystals have endured both plastic and brittle deformation during the growth history. Abundant deformation and resorption/growth features suggest a highly dynamic growth environment for super-deep diamonds. High temperatures expected in the transition zone and lower mantle could explain the plastic deformations of super-deep diamonds with low nitrogen content.
The aim of the study was to determine the efficacy of recombinant human interferon lambda 1 (IFN-λ1) against human adenovirus serotype 5 in a culture of human conjunctival cells Chang conjunctiva clone 1-5c-4. Material and methods. The study design consisted of three experimental schemes, reflecting a prophylactic and two options for a therapeutic and prophylactic treatment regimen (with the constant presence of the virus in the culture medium and with its removal after adsorption). The antiviral activity of IFN-λ1 was determined by the number of viable cells after exposure to the virus (MTT test). Results and discussion. It has been established that IFN-λ1 has antiviral activity against human adenovirus in vitro under a prophylactic and therapeutic-prophylactic scheme of administration at an infection dose of 1 and 10 TCID 50 (50% tissue culture infectious dose), but not at an infection dose of 100 TCID 50 . The antiviral effect of the use of IFN-λ1 in a therapeutic and prophylactic regimen at an infection dose of 1 TCID 50 was comparable to that of IFN-α. At the same time, both interferons did not have a toxic effect on the cell culture even at a concentration of 84 and 58 μg/ml, respectively. The antiviral activity and the absence of cytotoxic action provide the basis for further study of the possibility of development of based on IFN-λ1 drug for eye conjunctiva viral diseases treatment.
This article provides an overview of the metaanalyzes (PubMed, 19952019) of alcohol and non-alcoholic (coffee, tea, dairy products) beverage consumption in relation to risk of pancreatic cancer PC (PubMed, 19952019). Increased the PC risk was associated with high alcohol intake. The increased risk for heavy drinking did not explained by residual confounding by history of pancreatitis or tobacco smoking or diabetes. Light-moderate alcohol intake may reduced the PC risk, probably due to the fasting insulin levels decrement, which leads to the diminished the РС risk. The association between alcohol and the PC was stronger in men than in women. Some metaanalyzes demonstrated that a small amount of coffee may reduce PC risk, and a large amount to increase PC risk. Another meta-analyzes have not confirmed any association between the PC risk and coffee or tea consumption. One meta-analysis revealed a direct association of the PC risk with the dairy products consumption, but most research showed no such connection. Nutrition is considered to be associated with the PC risk, but the degree of risk due to structure of beverages consumption (dose, duration, alcohol, coffee, tea, dairy products pattern) is still not clear.
Using an modern many-particle method for the derivation of non-Markovian binary kinetic equations, we have treated theoretically the applicability of the encounter theory (ET) (the prototype of the collision theory) concepts to the widely known diffusion assisted irreversible bulk reaction A+A-->product (for example, radical reaction) in dilute solutions.

The method shows that the agreement with the ET is observed when the familiar integral ET is employed which in this method is just a step in the derivation of kinetic equations. It allows for two-particle correlations only, but fails to take account of correlation of reactant simultaneously with the partner of the encounter and the reactant in the bulk. However, the next step leading to the modified ET under transformation of equations to the regular form both extends the time range of the applicability of ET rate equation (as it was for reactions proceeding with one of the reactants in excess), and gives the equation of the generalized ET.

In full agreement with physical considerations, this theory reveals macroscopic correlations induced by the encounters in the reservoir of free walks. This means that the encounters of reactants in solution are correlated on a rather large time interval of the reaction. Though any nonstationary (non-Markovian) effects manifest themselves rather weakly in the kinetics of the bimolecular reaction in question, just the existence of the revealed macroscopic correlations in the binary theory is of primary importance. In particular, it means that the well-known phenomena which are generally considered to be associated solely with correlation of particles on the encounter (for example, chemically induced dynamic nuclear polarization) may be induced by correlation in the reservoir of free random walks of radicals in solution.
Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly polarized, catalyst-free fluids can be obtained in a catalysis-free regime using a chemical reaction with molecular addition of parahydrogen to a water-soluble Rh(I) complex carrying a payload of compound with unsaturated (C═C) bonds. Hydrogenation of norbornadiene leads to formation of norbornene, which is eliminated from the Rh(I) complex and, therefore, leaves the aqueous phase and becomes a gaseous hyperpolarized molecule. The Rh(I) metal complex resides in the original liquid phase, while the product of hydrogen addition is found exclusively in the gaseous phase based on the affinity. Hyperpolarized norbornene (1)H NMR signals observed in situ were enhanced by a factor of approximately 10,000 at a static field of 47.5 mT. High-resolution (1)H NMR at a field of 9.4 T was used for ex situ detection of hyperpolarized norbornene in the gaseous phase, where a signal enhancement factor of approximately 160 was observed. This concept of stoichiometric as opposed to purely catalytic use of PHIP-available complexes with an unsaturated payload precursor molecule can be extended to other contrast agents for both homogeneous and heterogeneous PHIP. The Rh(I) complex was employed in aqueous medium suitable for production of hyperpolarized contrast agents for biomedical use. Detection of PHIP hyperpolarized gas by low-field NMR is demonstrated here for the first time.
A ground-based laser system for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the atmosphere. We demonstrate that for the relevant laser parameters, this self-focusing can noticeably decrease the laser intensity on the target. We show that the detrimental effect can be, to a great extent, compensated for by applying the optimal initial beam defocusing. The effect of laser elevation on the system performance is discussed. A study of ground-based laser schemes for removing space debris concludes that beam self-focusing may be an issue. The concept of laser space cleaning entails using powerful lasers to knock debris out of its original orbit so that it moves to a lower orbit and ultimately burns up in the atmosphere. Alexander Rubenchik and co-workers have now studied the optical effects of transmitting such powerful beams through the atmosphere and conclude that nonlinear effects such as self-focusing, stimulated Raman scattering and turbulent broadening of the beam will need to be mitigated. Fortunately, locating the laser at an altitude of 4000 m above sea level and carefully controlling its beam size, pulse duration and initial defocusing can help to compensate for such nonlinear effects and thus make the approach feasible.
For a long time, functional Java programming was not possible. However, lambda expressions appeared in version 8 of the Java language. Due to the support of standard library classes (Stream, Optional, etc.) in Java, it became possible to describe transformations over data in a functional style. Java is a rather old language with a large imperative code base written in it.

Using IntelliJ Idea as a platform software tool was developed that allows you to find places where it is possible to automatically convert an imperative code to an equivalent code that uses Stream API, as well as an automatic fix that allows you to make a replacement. Refactoring uses IntelliJ Idea framework to analyze Java code, and integrates into the IDE itself. One of the main criteria for the correct operation of the algorithm is the security of this transformation. The user cannot trust the tool if the transformation can change the semantics of the code. This article discusses various constraints that are imposed on code patterns so that transformation without distortion of semantics is possible.

Refactoring has been tested in various libraries to verify the semantics are preserved by checking the test results before and after applying refactoring. This article will not describe the impact of using the Stream API on the performance of the application.
Aging is a major risk factor of numerous human diseases. Adverse genetic variants may contribute to multiple manifestations of aging and increase the number of comorbid conditions. There is evidence of links between hypertension and age-related diseases, although the genetic relationships are insufficiently studied.

Here, we investigated the contribution of hypertension to the development of accelerated-senescence syndrome in OXYS rats. We compared transcriptome sequences of the prefrontal cortex, hippocampus, and retina of OXYS rats with the genotypes of 45 rat strains and substrains (which include models with hypertension) to find single-nucleotide polymorphisms (SNPs) both associated with hypertension and possibly contributing to the development of age-related diseases.

A total of 725 polymorphisms were common between OXYS rats and one or more hypertensive rat strains/substrains being analyzed. Multidimensional scaling detected significant similarities between OXYS and ISIAH rat genotypes and significant differences between these strains and the other hypertensive rat strains/substrains. Nonetheless, similar sets of SNPs produce a different phenotype in OXYS and ISIAH rats depending on hypertension severity. We identified 13 SNPs causing nonsynonymous amino-acid substitutions having a deleterious effect on the structure or function of the corresponding proteins and four SNPs leading to functionally significant structural rearrangements of transcripts in OXYS rats. Among them, SNPs in genes Ephx1, Pla2r1, and Ccdc28b were identified as candidates responsible for the concomitant manifestation of hypertension and signs of accelerated aging in OXYS rats.
Measurements of the branching fractions of and decays are performed using a data sample corresponding to of proton-proton collision data collected with the LHCb detector at a centre-of-mass energy of , where the mesons are reconstructed in the final state. The first observation of the decay and the first evidence for the decay are reported with branching fractions
Neutron veto detector based on liquid scintillator containing hydrogen atoms is an integral part of any underground experiment for dark matter search. So far, a flammable mixture of liquid hydrocarbons was used as a liquid scintillator in such detectors.

In this work, we have studied the primary scintillations in pure liquid argon and its mixtures with methane, the CH4 content varying from 100 ppm to 5%.

The primary scintillations have for the first time been observed in liquid argon doped with methane, in the visible and near infrared range, and their relative light yields have been measured as a function of the CH4 content.
The processes of heat and mass transfer in systems with liquid-gas interface are of interest to a wide range of problems. Destruction dynamics of thin horizontal layers of silicone oils were investigated using confocal sensor on a 3D-positioning system. The numerical solution of the problem was obtained in the lubrication approximation theory for two-dimensional axisymmetric thermocapillary flow. The model takes into account the surface tension, viscosity, gravity and heat transfer in the substrate. The numerical algorithm for the joint solution of the energy equation and the evolution equation for the liquid layer thickness has been developed. The establishment method was used to obtain the stationary solutions. Experimental measurements and numerical calculations were made for silicone oils of different viscosities, heating power and initial thickness. The significant effect of the surface tension coefficient and its temperature coefficient on thermocapillary deformation was detected. It was experimentally established that the deformation value depends on a heat flux value. A liquid bump is formed at the boundary of the heating region that is also observed in numerically calculated profiles.
The Klyuchevskoy group of volcanoes (KGV) in Kamchatka includes three presently active volcanoes (Klyuchevskoy, Bezymianny, and Tolbachik) located close together in an area of approximately 50 × 80 km. These three volcanoes have completely different compositions and eruption styles from each other. We have analyzed new data recorded by a temporary seismic network consisting of 22 seismic stations operated within the area of Tolbachik in 2014–2015 in conjunction with the data from the permanent network and the temporary PIRE network deployed at the Bezymianny volcano in 2009. The arrival times of the P and S waves were inverted using a local earthquake tomography algorithm to derive 3‐D seismic models of the crust beneath the KGV as well as accurate seismicity locations. High‐resolution structures beneath the Tolbachik volcanic complex were identified for the first time in this study. The tomography results reveal three different types of feeding system for the main KGV volcanoes. The basaltic lavas of the Klyuchevskoy volcano are supplied directly from a reservoir at a depth of 25–30 km through a nearly vertical pipe‐shaped conduit. The explosive Bezymianny volcano is fed through a dispersed system of crustal reservoirs where a lighter felsic material separates from the mafic component and ascends to the upper crust to form andesitic magma sources. For Tolbachik, low‐viscosity volatile‐saturated basalts ascend from two deep reservoirs following a system of fractures in the crust associated with the intersections of regional faults.
To describe the dynamics of a viscous heat-conducting gas, we use the complete system of Navier—Stokes equations with allowance for heat fluxes. Mathematical description of the dynamics of liquid metals under high-energy external influences (laser radiation or plasma flow) includes, in addition to the Navier—Stokes system of an incompressible viscous fluid, also heat fluxes and processes of nonequilibrium crystallization of a deformable fluid. Differentially invariant solutions are a generalization of partially invariant solutions, and their active study for various models of continuous medium mechanics is just beginning. In the construction of partially invariant and differentially invariant solutions, there are overdetermined systems of differential equations that require a compatibility analysis. The algorithms for reducing such systems to involution in a finite number of steps are described by Cartan, Finikov, Kuranishi, and other authors.

In this paper, differential invariants are used to construct solutions for equations of the dynamics of a viscous heat-conducting gas and the dynamics of a viscous incompressible fluid modified by nanopowder inoculators. Differentially invariant solutions can also be considered as solutions with differential constraints; therefore, when developing them, the approaches and methods developed by the science schools of academicians N. N. Yanenko and A. F. Sidorov will be actively used. However, the difficultly foreseeable volume of intermediate calculations complicates their practical application. Therefore, the methods of computer algebra are actively used here, which largely helps in solving this difficult problem.

It is proposed to use the constructed exact solutions as tests for formulas, algorithms and their software implementations when developing and creating numerical methods and computational program complexes. This combination of effective numerical methods, capable of solving a wide class of problems, with analytical methods makes it possible to make the results of mathematical modeling more accurate and reliable.
Newcastle disease virus (NDV) isolates from wild duck and pigeon in Russia

complete genome sequencing and comparative sequence analysis of the F gene

strains classified as NDV class II, genotypes VIId and VIb/2
Bacteriophage T7 early transcripts were used as carriers of alkylating groups to affect complementary T7 DNA sites for inducing mutations in preselected genes. A heterofunctional polyalkylating agent N,N,N'-tri-(beta-chloroethyl)-N'-(p-formylphenyl)propylene diamine-1,3 was attached to 3-5% of the transcript nucleotides. The controlled alkylating groups carried on RNA were activated after RNA . DNA hybridization. The modified transcripts were shown to hybridize only with the complementary H strand and to form covalently bound R loops in the appropriate T7 sites. The T7 DNA molecules locally alkylated by the modified transcripts of gene 1.3 coding for T7 ligase were packaged into T7 proteins and used to infect Escherichia coli B. As judged by plating efficiency and the ligase-deficient E. coli BL2 strain, 4 of 140 plaques obtained after infection contained mutants defective in gene 1.3 in amounts of 0.7-1.5%. The T7 DNA locally alkylated by the modified transcripts of gene 0.3 and 1.1 were used for the transfection of E. coli C1757. Analysis of 24 plaques produced by transfection indicated that 3 contained mutants defective in gene 0.3 in amounts of 2-10%. The mutants had also a second unidentified mutation. Complementation analysis data suggest that the second mutation is due to a defect in gene 1.1. The results obtained demonstrate the efficiency of the approach developed for gene-directed mutagenesis.
Background/Aims: Renal principal cells maintain their intracellular water and electrolyte content despite significant fluctuations of the extracellular water and salt concentrations. Their water permeability decreases rapidly (within a few seconds) after successive hypo-osmotic shocks. Our aim was to investigate the contribution of the apical and basolateral surface to this effect and the potential influence of fast reduction in AQP-2, -3 or -4 plasma membrane content. Methods: Rat principal cells of kidney collecting duct fragments underwent hypo-osmotic challenge applied apically or basolaterally and the regulatory volume decrease (RVD) was measured by the calcein quenching method. The AQP -2, -3 and -4 content of the plasma membrane fraction was quantified by Western blotting. Results: The hypo-osmotic shock applied apically causes rapid swelling with high apparent water permeability and fast RVD. An identical successive shock after 15-20 sec causes significantly lower swelling rate with 3-fold reduction in apparent water permeability. This reaction is accompanied by AQP2 decrease in the plasma membrane while AQP3 and AQP4 are unaffected. The contribution of the basolateral cell surface to RVD is significantly lower than the apical. Conclusion: These results indicate that in principal cells the effective mechanism of RVD is mainly regulated by the apical cell plasma membrane.