Hengzongshu/ArticleAgent huggingface dataset:
The rate‐limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase (TPH), was studied in brain areas of male mice with repeated experience of victory (winners) or defeat (losers) gained in 10 daily agonistic confrontations. A reduction of TPH activity in the midbrain and an increase in the hypothalamus was demonstrated for winners compared with controls. In contrast, repeated defeat in social confrontations was associated with higher TPH activity in the striatum and hypothalamus in losers compared with controls. Agonistic interactions did not affect TPH activity in the amygdala, nucleus accumbens or hippocampus in either winners or losers. The sensory contact technique used in this work for generating winners and losers may be productive in the analysis of TPH gene regulation.
During the First Intermediate Period in the Denderite nome false-door stelae were a luxury appropriate only for top officials and their nearest relatives. However, the false door of Neferiu is an exception to this rule. He is not said to have held any office, and although his ranking titles seem relatively high, we know that at that period such titles were often appropriated by provincials devoid of top positions.

Thus, on account of his low 'official status' (if any at all), Neferiu needed to inventively justify his moral right to his prestigious false door, and this is the purport of his inscription on its right jambs. The reference to 'nourishing (even) the great' implies that in the year of famine Neferiu, owing to his wealth and generosity, turned out to be a more useful person for his town than even its top officials.

His claims that he 'was aggrandized beyond great men and officials' and praised by 'the entire town' also put him on a par with local magnates. His prosperous longevity, 'documented' by his 'elderly' representation on the left, is said to have been granted by the god Iqer (in gratitude for the salvation of his townspeople, the god's flock and providers). Meanwhile, it was mostly nomarchs and overseers of priests who attributed their good fortune to the favor of a local god.
Arabinogalactan, a water-soluble natural polysaccharide, has potent innate immuno-modulatory and anti-cancer activity and can serve as a carrier material in targeted drug delivery. The molecular weight and supramolecular structure of the polymer are very important for its pharmacological and technological applications. In this work, we used synchrotron small-angle X-ray scattering as an instrument to study the supramolecular structure of arabinogalactan in aqueous solutions. The formation of polymer associates was confirmed also by means of the terahertz laser ablation and atomic force microscopy studies. SAXS experiments were made at accelerators complex VEPP-3/VEPP-4.
A parallel server system with n identical servers is considered. The service time distribution has a finite mean 1 / μ, but otherwise is arbitrary. Arriving customers are routed to one of the servers immediately upon arrival.

The join-idle-queue routeing algorithm is studied, under which an arriving customer is sent to an idle server, if such is available, and to a randomly uniformly chosen server, otherwise. We consider the asymptotic regime where n → ∞ and the customer input flow rate is λ n.

Under the condition λ / μ < ½, we prove that, as n → ∞, the sequence of (appropriately scaled) stationary distributions concentrates at the natural equilibrium point, with the fraction of occupied servers being constant at λ / μ. In particular, this implies that the steady-state probability of an arriving customer waiting for service vanishes.
Eigenvalue-type equations for Löwdin-Amos-Hall spin-paired (corresponding) orbitals are developed to provide an alternative to the standard spin-polarized Hartree-Fock or Kohn-Sham equations in dealing with broken-symmetry (BS) states.

To derive paired orbitals for different spins (PODS) equations there has been applied Adams-Gilbert 'localizing' operator approach. The PODS equations contain different operators for different spins the eigenvectors of which are paired orbitals associated with the same eigenvalue for each pair.

Preliminary applications to simple systems show viability of this approach. Although the spectrum of possible applications of the PODS equations seems to be quite wide, they would be especially useful for obtaining and analyzing the S(z) = 0 BS solutions for the systems with antiferromagnetic structure.
The tenoxicam (4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide), is a non-steroidal antiinflammatory drug (NSAID), member of oxicam family, widely used in the treatment of osteoporosis.Tenoxicam (TXM) could be present in the β-keto-enolic form (BKE) or β-diketone (BDK) and in a zwitterionic form (ZWC) (Figure 1).However, in solid form (more than 20 different compounds including polymorphic modifications, co-crystals, and solvates) [1 and present work] TXM has predominantly found in the zwitterionic form (ZWC).While in a dissolved form, keto-enolic equilibrium is observed since recorded by us experimental absorption and fluorescence spectra for various TXM solutions show presence two forms of TXM (called A and B) in solvents with high polarity and only A form of TNX in low polar solvents (cyclohexane, toluene, chloroform, dioxane).This led us to think about the possibility to obtain solid forms of tenoxicam contain it in BKE or BDK form.
The motivation of this work is connected with recent studies, both numerical and experimental, on study of emitted vortex loops.

The investigation is performed on the supposition that the vortex loops have the Brownian or random walking structure with the generalized Wiener distribution. The statistics of vortex loops emitted from the domain with quantum turbulence is studied.

We demonstrated how the statistics of emitted loops is expressed in terms of the vortex tangle parameters and performed the comparison with numerical simulations. This technique opens up new opportunities to probe superfluid turbulence. The main goal is to relate the properties of the emitted vortex loops with the parameters of quantum turbulence.
analytical two-soliton solutions of the nonlinear Schrodinger equation

numerical simulations of the soliton interactions in the Dyachenko–Zakharov equation for the envelope of gravity waves in deep water

The relative phase of the solitons is shown to be the key parameter determining the dynamics of the interaction. We find that the maximum of the wave field can significantly exceed the sum of the soliton amplitudes. The solitons lose up to a few percent of their energy during the collisions due to radiation of incoherent waves and in addition exchange energy with each other. The level of the energy loss increases with certain synchronization of soliton phases. Each of the solitons can gain or lose the energy after collision, resulting in increase or decrease in the amplitude. The magnitude of the space shifts that solitons acquire after collisions depends on the relative phase and can be either positive or negative.
Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P ‐value below 10 −5 . Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain‐related disorder via breath, in this case CP.
Reptiles are good objects for studying the evolution of sex determination, since they have different sex determination systems in different lineages. Lacertid lizards have been long-known for possessing ZZ/ZW type sex chromosomes. However, due to morphological uniformity of lacertid chromosomes, the Z chromosome has been only putatively cytologically identified.

We used lampbrush chromosome (LBC) analysis and FISH with a W-specific probe in Eremiasvelox (Pallas, 1771) to unequivocally identify the ZW bivalent and investigate its meiotic behavior.

The heterochromatic W chromosome is decondensed at the lampbrush stage, indicating active transcription, contrast with the highly condensed condition of the lampbrush W chromosomes in birds. We identified the Z chromosome by its chiasmatic association with the W chromosome as chromosome XIII of the 19 chromosomes in the LBC karyotype. Our findings agree with previous genetic and genomic studies, which suggested that the lacertid Z chromosome should be one of the smaller macrochromosomes.
The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (AD). Nonetheless, it now seems increasingly unlikely that amyloid toxicity is the cause of sporadic AD, which leads to cognitive decline.

Here, using accelerated-senescence nontransgenic OXYS rats, we confirmed that aggregation of Aβ is a later event in AD-like pathology. We showed that an age-dependent increase in the levels of Aβ 1–42 and extracellular Aβ deposits in the brain of OXYS rats occur later than do synaptic losses, neuronal cell death, mitochondrial structural abnormalities, and hyperphosphorylation of the tau protein. We identified the variants of the genes that are strongly associated with the risk of either late-onset or early-onset AD, including App, Apoe4, Bace1, Psen1, Psen2, and Picalm. We found that in OXYS rats nonsynonymous SNPs were located only in the genes Casp3 and Sorl1.

Thus, we present proof that OXYS rats may be a model of sporadic AD. It is possible that multiple age-associated pathological processes may precede the toxic amyloid accumulation, which in turn triggers the final stage of the sporadic form of AD and becomes a hallmark event of the disease.
The study of the outflow process was carried out both for horizontal and vertical outflow of liquid from the source in the direction of gravity. The condition was met for maintaining the residual gas background pressure in the discharge chamber much lower than the saturated vapor pressure of the working fluid at the selected discharge temperature.

Experimental results of observation of ethanol and propylene glycol microjets flowing into a highly rarefied medium (vacuum) through a nozzle are presented.

It is established that the flow from a thin capillary or small-diameter nozzle into a vacuum or highly rarefied gas medium differs significantly from the well-studied flow modes into a dense gas medium. It is shown that in all studied regimes the fluid flow is statistically unstable, with a large number of sudden changes in direction, structure, and observed density. The paper describes the main features of such a flow and the conditions for the onset of instability.
Protocyanin is a complex pigment extracted from flower petals of blue cornflower, Centaurea cyanus.The components of protocyanin were recently demonstrated to be anthocyanin (AN), flavone glycoside (FL), Fe 3+ , Mg 2+ and Ca 2+ ions [1] .For X-ray structure determination, protocyanin was reconstructed from the components and crystallized in space group P2 1 2 1 2 1 with unit cell dimensions of a = 29.7,b = 49.2 and c = 78.3Å.Two protocyanin molecules are contained in an asymmetric unit.Data were collected on the beam line 6A at Photon Factory KEK to1.05 Å resolution.The refined molecule has pseudo three-fold symmetry and four metals align along the pseudo three-fold axis in order of Ca 2+ , Fe 3+ , Mg 2+ and Ca 2+ .The four metals are coordinated to six AN and six FL molecules.The inner Fe 3+ and Mg 2+ ions are each coordinated to three AN's, respectively, while the outer two Ca 2+ ions are each coordinated to three FL's.Both AN and FL molecules are self-associated with each other as AN-AN and FL-FL in pair and this hydrophobic association also exists between AN and FL molecules, building copigmentation stacks.Protocyanin is a tetra-metal (Fe 3+ , Mg 2+ , 2Ca 2+ ) nuclear complex, a new type of supramolecular pigment.
Cellularization of the Drosophila embryo is an unusually synchronous form of cytokinesis in which polarized membrane extension proceeds in part through incorporation of new membrane via fusion of apically-translocated Golgi-derived vesicles.We describe here involvement of the signaling enzyme Phospholipase D (Pld) in regulation of this developmental step. Functional analysis using gene targeting revealed that cellularization is hindered by the loss of Pld, resulting frequently in early embryonic developmental arrest. Mechanistically, chronic Pld deficiency causes abnormal Golgi structure and secretory vesicle trafficking.Our results suggest that Pld functions to promote trafficking of Golgi-derived fusion-competent vesicles during cellularization.
The optical properties of a number of Hg1-xCdxTe bulk epilayers (x = 0.152 - 0.23) and heterostructures with quantum wells (QW) based on narrow gap HgCdTe are examined aiming to reveal the prospects of such structures for laser development in long wave infrared and very long wave infrared ranges.

Experimental evidence of long wavelength superluminescence, i.e. amplification of spontaneous emission, at 8.4 μm in narrow gap HgCdTe bulk epitaxial film at 100 K is reported.

Employing heterostructures with QW is demonstrated to be promissory for furthering the radiation wavelength to 10 - 30 μm range.
Longitudinal and tangential components of the mean velocity field inside the Ranque tube of square cross section are presented for a central longitudinal section. Measurements are carried at central plane over the entire tube, with 1-2 millimeter step in transverse direction and with 10 millimeter step along the tube. The data is presented in the form of velocity maps.
We study the γ*γ* total cross section in the NLA BFKL approach. We have extracted the NLO corrections to the photon impact factor from two recent papers of Balitsky and Chirilli and Chirilli and Kovchegov and used them to build several representations of the total cross section, equivalent within the NLA. We have combined these different representations with two among the most common methods for the optimization of a perturbative series, namely PMS and BLM, and compared their behavior with the energy with the only available experimental data, those from the LEP2 collider.
Simulation of background particle fluxes generated by colliding beams is performed with FLUKA package for the Super C-Tau factory Detector (SCTD). Two processes are considered as main sources of luminosity generated background: two-photon production of electron-positron pairs and Bha-Bha scattering with bremsstrahlung photon emission (radiative Bha-Bha). The SCTD geometry is described corresponding to the last version of the Conceptual Design Report. The magnetic field based on the calculation in ANSYS is introduced in the model. Main results of the simulation for beam energy of 3 GeV, luminosity of 10 35 cm −2 s −1 and 1.5 T magnetic field are the following: charged particle fluence in the region of the Inner Tracker (radius 5cm -20 cm, Z between -30cm and 30 cm) is between 10 5 particles/(cm 2 s) and ∼10 3 particles/(cm 2 s); 1-MeV neutron equivalent fluence for Si in the regions corresponding to electronics of the Inner Tracker and the Drift Chamber is below 10 11 n/(cm 2 y) and absorbed dose is below 100 Gy/y in the hottest regions of the detector.
ABSTRACT Back pain (BP) is a common condition of major social importance and poorly understood pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts allowed us to perform a very large GWAS (total N = 509,070) and examine the genetic correlation and pleiotropy between BP and its clinical and psychosocial risk factors. We identified and replicated three BP associated loci, including one novel region implicating SPOCK2 / CHST3 genes. We provide evidence for pleiotropic effects of genetic factors underlying BP, height, and intervertebral disc problems. We also identified independent genetic correlations between BP and depression symptoms, neuroticism, sleep disturbance, overweight, and smoking. A significant enrichment for genes involved in central nervous system and skeletal tissue development was observed. The study of pleiotropy and genetic correlations, supported by the pathway analysis, suggests at least two strong molecular axes of BP genesis, one related to structural/anatomic factors such as intervertebral disk problems and anthropometrics; and another related to the psychological component of pain perception and pain processing. These findings corroborate with the current biopsychosocial model as a paradigm for BP. Overall, the results demonstrate BP to have an extremely complex genetic architecture that overlaps with the genetic predisposition to its biopsychosocial risk factors. The work sheds light on pathways of relevance in the prevention and management of LBP.
Phosphine-thioether ligands were coordinated to the Mo3S4 cluster to afford [Mo3S4Cl3(PS)3]+ complexes. Their catalytic activity in nitrobenzene reduction reflects the different hemilabile behaviours of PS1, PS2 and PS3.
digital back-propagation method

application of dynamic multi-layer perceptron networks for long haul transmission systems

showing performance improvement and significant superiority of neural network complexity over digital back-propagation method
The interest in this regime of beam-plasma interaction is associated with highly efficient generation of electromagnetic waves near the plasma frequency harmonics that has been recently observed in laboratory experiments on the GOL-3 mirror trap. It has been found that the radiation power only from the vicinity of the doubled plasma frequency in these experiments can reach 1% of the total beam power. Subsequent theoretical and simulation studies have shown that the most likely candidate for explaining such efficient generation of electromagnetic radiation is the mechanism of a beam-driven plasma antenna based on the conversion of the most unstable plasma oscillations on a longitudinal density modulation of plasma ions.

In this paper, electromagnetic emissions produced by a beam-plasma system are investigated using particle-in-cell simulations for the particular case when the typical transverse size of both the 100 keV electron beam and the produced plasma channel is comparable to the radiation wavelength. In this paper, we investigate how effectively this mechanism can work in a real experiment at the GOL-3 facility, when a thin subrelativistic electron beam gets a large angular spread due to compression by a magnetic field, and the gas into which it is injected has macroscopic density gradients.
This work presents the results of experiments using synchrotron radiation from the VEPP-4M accelerator complex at Budker Institute of Nuclear Physics.

Dynamic of small-angle X-ray scattering of synchrotron radiation was implemented on the synchrotron radiation beamline 8-b. Here given beam parameters and described elements of the station and detector system. The distance from the axis of the explosive charge to the detector was 3432 mm. The strip size of the detector DIMEX was 0.1 mm. Thus, a single channel of the detector DIMEX in these experiments corresponded to the scattering angle 2θ: 1 detector channel = 0.02914 mrad. The SAXS measurement technique on this station enables detection of nanoparticles ranging in size from 2 nm to 200 nm with exposure time 73 ps for one frame. It is possible to record 100 frames with interval 100 ns. In this work used TNT with 30 mm in diameter and 55 mm in length.

Ultra fine diamonds of 2 nm size was detected behind the detonation front, after that the average size of particles increases up to 5–6 nm during few microseconds.
This letter describes the observation of the light-by-light scattering process, γγ→γγ, in Pb+Pb collisions at √s_NN = 5.02 TeV.

The analysis is conducted using a data sample corresponding to an integrated luminosity of 1.73 nb⁻¹, collected in November 2018 by the ATLAS experiment at the LHC. Light-by-light scattering candidates are selected in events with two photons produced exclusively, each with transverse energy E_T^γ > 3 GeV and pseudorapidity |η_γ| < 2.37, diphoton invariant mass above 6 GeV, and small diphoton transverse momentum and acoplanarity.

After applying all selection criteria, 59 candidate events are observed for a background expectation of 12 ± 3 events. The observed excess of events over the expected background has a significance of 8.2 standard deviations. The measured fiducial cross section is 78 ± 13 (stat.) ± 7 (syst.) ± 3 (lumi.) nb.
High energy photon colliders (γγ,γe) are based on e - e - linear colliders where high energy photons are produced using Compton scattering of laser light on high energy electrons just before the interaction point. This paper is a part of the Technical Design Report of the linear collider TESLA. 1 Physics program, possible parameters and some technical aspects of the photon collider at TESLA are discussed.
A convenient one-pot approach to alkylcyanobiaryls is described. The method is based on biaryl cross-coupling between the sodium salt of the terephthalonitrile dianion and a neutral aromatic nitrile in liquid ammonia, and successive alkylation of the long-lived anionic intermediate with alkyl bromides. The reaction is compatible with benzonitriles that contain methyl, methoxy and phenyl groups, fluorine atoms, and a 1-cyanonaphthalene residue. The variety of ω-substituted alkyl bromides, including an extra bromine atom, a double bond, cyano and ester groups, as well as a 1,3-dioxane fragment are suitable as alkylation reagents.
The translation start site plays an important role in the control of translation efficiency of eukaryotic mRNAs. The recognition of the start AUG codon by eukaryotic ribosomes is considered to depend on its nucleotide context. However, the fraction of eukaryotic mRNAs with the start codon in a suboptimal context is relatively large. It may be expected that mRNA should possess some features providing efficient translation, including the proper recognition of a translation start site. It has been experimentally shown that a downstream hairpin located in certain positions with respect to start codon can compensate in part for the suboptimal AUG context and also increases translation from non-AUG initiation codons. Prediction of such a compensatory hairpin may be useful in the evaluation of eukaryotic mRNA translation properties. We evaluated interdependency between the start codon context and mRNA secondary structure at the CDS beginning: it was found that a suboptimal start codon context significantly correlated with higher base pairing probabilities at positions 13 – 17 of CDS of human and mouse mRNAs. It is likely that the downstream hairpins are used to enhance translation of some mammalian mRNAs in vivo. Thus, we have developed a tool, AUG_hairpin, to predict local stem-loop structures located within the defined region at the beginning of mRNA coding part. The implemented algorithm is based on the available published experimental data on the CDS-located stem-loop structures influencing the recognition of upstream start codons. An occurrence of a potential secondary structure downstream of start AUG codon in a suboptimal context (or downstream of a potential non-AUG start codon) may provide researchers with a testable assumption on the presence of additional regulatory signal influencing mRNA translation initiation rate and the start codon choice. AUG_hairpin, which has a convenient Web-interface with adjustable parameters, will make such an evaluation easy and efficient.