Hengzongshu/ArticleAgent huggingface dataset:
The present study aimed to analyze possible associations of rs7412 and rs429358 of the APOE gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 subjects, age 53.8 ± 7.0 years, males/females 50/50). PCR was conducted with fluorescence detection according to the TaqMan principle on a real-time PCR machine. The frequency of a minor allele (C) of rs429358 was 0.13, and the frequency of a minor allele (T) of rs7412 was 0.09. In our study, the woman with the rare ɛ1/ɛ4 genotype had substantial aberrations in blood lipid levels. In Kaplan-Meier curves, statistically significant differences were revealed in the prognosis of survival within the subgroup of females who had a myocardial infarction (p = 0.0006): the prognosis was worse for carriers of the ɛ2/ɛ2 genotype and for ɛ4/ɛ4 carriers. Survival analysis regarding deaths from all causes showed (p = 0.0238) that female carriers of the ɛ2/ɛ4 genotype had a worse prognosis than did carriers of other genotypes. Thus, in the population of Western Siberia (Russia), we confirmed statistically significant associations between rs7412 & rs429358 genotypes and lipid profile parameters.
This method has been developed and published by the authors of the present article earlier.

The assessment is based on structural models and formation conditions reconstruction for the reservoir’s constituents, permeable complex and caprock. Tectonic and lithologic-and-facies criteria are considered.

In this article, the results are shown of quantitative oil-and-gas potential assessment for the most promising Bathonian regional reservoir of the Jurassic sediments in the Yenisei-Khatanga territory and the adjacent territory of the Gydan petroleum province. The methodology and results of the oil-and-gas potential assessment of the Bathonian reservoir are described.
The interaction of potassium bismuth citrate (PBC) with polysaccharides of various structures – dextran (linear) and arabinogalactan (branched) was investigated. The NMR method revealed the donor-acceptor character of the interaction of dextran with PBC in water solutions. Synchrotron radiation and transmission electron microscopy was show the formation of the anisotropic PBC-nanocrystals the covered of dextran layers.
Reported traditional gender role attitudes (GRAs) have been related to worse mental health in western countries.

This study examined the link of GRAs with symptoms of depression and generalised anxiety disorder (GAD) in two Russian cities. We used interview data from the cross-sectional Know Your Heart Study conducted among 5099 adults aged 35-69 in the Russian cities of Arkhangelsk and Novosibirsk between 2015 and 2017. Attitudes about gender inequality and division of labour between women and men at home or in the public sphere were measured by single items. Binary variables indicating presence of symptoms of depression and GAD were defined by a cut-off of ≥ 5 of the PHQ-9 and GAD-7 scores respectively. Multivariable logistic regression was used to determine crude and adjusted associations.

There was evidence that all types of GRAs were associated with symptoms of depression and GAD consistent with a U-shape after controlling for confounding with stronger evidence for all relationships for depression than for GAD. Odds of depressive symptoms were elevated among participants strongly agreeing to gender inequality and gender division of labour. There was good evidence for effect measure modification by age. The possibilities of measurement error of the exposure and outcomes, residual confounding and reverse causality are important limitations of this study. Agreeing to gender inequality and gender division of labour was associated with reporting symptoms of common mental disorders in Russia. This study adds evidence for a link of GRAs with mental health from a non-western context.
This article presents the results of approbation of the method for registering temperature distributions based on the planar laser-induced fluorescence of a hydroxyl radical (OH) when the band (1-0) of the A 2 Σ + –X 2 Π system is excited. The thermometry is based on the recording the ratio of the radiation intensity of the band (2-0) and the bands (0-0), (1-1). Numerical modelling of fluorescence spectra is performed using the LASKIN program for the most frequent excitation lines Q 2 (7), Q 1 (8), R 1 (14), P 1 (2). The temperature field of a swirling flame, impinging on a flat cold surface, for H / d = 1, 2 and 3 calibres (where H is the distance between the jet nozzle and the surface, d is the outlet diameter of the nozzle) is obtained. The results of the work demonstrate that when the transition Q 1 (8) is excited, the ratio of the intensity of fluorescence signals for the band (2-0) and the bands (0-0), (1-1) provides a high sensitivity to temperature and is not significantly affected by fluorescence quenching. The report also concludes that this method can be implemented using single pulsed laser illumination and is effective for the detecting the position of flow recirculation zones and registering hot heat release zones with the combustion products.
Activities of the European explorers, French in particular, in the territory of Central Asia not once have been the subject of attention and research by specialists. However, only a few mentions in scientific literature can be found about the work of Ch.-E. Ujfalvy in the territory of Jetysu. They are particularly small in number and contain either mentions about the fact of that journey or general descriptions of the expedition.

Analysis of archaeological materials gathered by scientists has not been carried out before. The expeditionary route passed through territories that the French author called the Russian Turkestan, by limiting it to Semey in the north, Zarafshan in the south, Fergana Valley in the east and Aral Sea in the west.

Ch.-E. Ujfalvy's monograph includes not only texts, but also illustrative material. He also outlined the archaeological sites and findings among the landscaping and natural attractions described by the explorer. He has covered some of them in text and some are simply sketched and attached as illustrations to the monograph. The scientist highlights several types of archaeological objects. The article provides a data review about archaeological antiquities of the Jetysu region, gathered by Ch.-E. Ujfalvy in the course of his expedition.
MOTIVATION: Gene networks that provide the regulation of physiological processes are the basic feature of organisms. Information regarding the regulation of gene expression and signal transduction pathways is increasing rapidly. However, the information is hard to formalize and systematize. Ways and means for automated visualization of the gene networks based on their formalized description are needed. RESULTS: The object-oriented database GeneNet and the software for its automated visualization have been developed. The main principles of a formalized description of the gene network have been worked out. Antiviral response and erythropoiesis are provided as examples to show how this is achieved. The GeneNet graphical user interface written in Java provides automated generation of the gene network diagrams and allows visualization and exploration of the GeneNet database through the Internet. A system of filters allows the selection of particular components of the network for visualization. AVAILABILITY: The GeneNet database and its graphical user interface are available at http://wwwmgs.bionet.nsc.ru/systems/MGL/GeneN et/ CONTACT: fedor@bionet.nsc.ru
Aim : to evaluate the impact of tissue-engineered structures (TES) transplantation based on mesenchymal stromal cell (MSC) sheets in myocardial infarction on the activation of the epicardial cell pool and vascularization of the damaged zone.

Materials and methods . Mesenchymal stromal cells were obtained from samples of subcutaneous fat of Wistar rats and C57Bl/6 mice. Tissue engineering structures were obtained by culturing cell sheets on thermosensitive plates (Nunc Dishes with UpCell Surface). Transplantation of TESs was performed after myocardial infarction modeling in rats by ligation of the anterior descending coronary artery. Transplant cells and damaged zones were assessed using immunofluorescent staining of myocardial cryosections. The impact of MSC secretion products on the migration activity of epicardial cells in vitro was evaluated using the explant culture method.

Results . MSCs in TESs after transplantation remain viable and induce activation of the epicardial cell pool and local increase of the damaged zone vascularization. The in vitro experiments showed that the conditioned environment of MSCs stimulates the migratory activity of epicardial cells and initiates the formation of activated Wt1/POD1 precursor cells. Conclusion . TES transplantation on the basis of MSC sheets seems to be a promising approach for effective delivery of viable cells into myocardium to activate the epicardial cellular niche and reparative angiogenesis.
Общественная организация «Российская ассоциация эндокринологов» КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ САХАРНЫЙ ДИАБЕТ 1 ТИПА ТЕРМИНЫ И ОПРЕДЕЛЕНИЯ

Аналоги инсулина -форма инсулина, в которой произведены некоторые изменения в молекуле человеческого инсулина

Аналог действует так же, как инсулин, но с фармакокинетическими/фармакодинамическими различиями, которые могут иметь преимущества
The method is highly competitive with the known discrete layer peeling method in speed

A new numerical method is developed for solution of the Gel'fand - Levitan - Marchenko inverse scattering integral equations. The method is based on the fast inversion procedure of a Toeplitz Hermitian matrix and special bordering technique

exceeds it noticeably in accuracy at high reflectance
The coherent anti-Stokes Raman spectroscopy (CARS) has attracted a great attention as non-invasive method of real-time monitoring of processes occurring in biological tissues and cells. It needs a special kind of optical source that would be compact, stable and low cost.

We investigate a possibility of using highly-chirped dissipative soliton oscillator together with a narrowband fiber Bragg grating and all-fiber amplifier. Optical pulses with the duration of 85 ps and the peak power of 400 W were generated at the output of the fiber system with the repetition rate about 13 MHz.

Developed source is suitable to pump a fiber optical parametric oscillator for CARS.
A measurement of the $CP$ asymmetry in ${B}^{+}\ensuremath{\rightarrow}{K}^{+}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ decays is presented using $pp$ collision data, corresponding to an integrated luminosity of $1.0\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$, recorded by the LHCb experiment during 2011 at a center-of-mass energy of 7 TeV. The measurement is performed in seven bins of ${\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ invariant mass squared in the range $0.05<{q}^{2}<22.00\text{ }\text{ }{\mathrm{GeV}}^{2}/{c}^{4}$, excluding the $J/\ensuremath{\psi}$ and $\ensuremath{\psi}(2S)$ resonance regions. Production and detection asymmetries are corrected for using the ${B}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}{K}^{+}$ decay as a control mode. Averaged over all the bins, the $CP$ asymmetry is found to be ${\mathcal{A}}_{CP}=0.000\ifmmode\pm\else\textpm\fi{}0.033\text{ }(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}0.005\text{ }(\mathrm{syst})\ifmmode\pm\else\textpm\fi{}0.007$ ($J/\ensuremath{\psi}K$), where the third uncertainty is due to the $CP$ asymmetry of the control mode. This is consistent with the standard model prediction.
Antiphon (c. 480–411 BCE) was famous in antiquity for his forensic speeches as well as more theoretical works, such as The Truth and On concord. He is also credited with the invention of logography as a profession. The majority of his heritage is now lost.

The present publication contains a collection of scant doxographic evidence about Antiphon’s life and writings.

The evidences are based on A. Lask and G. Most’ Early Greek Philosophy (2016).
Background: Dendritic cells (DCs) are known to contribute to the pathogenesis of different autoimmune diseases. It is clear nowadays the role of DCs in rheumatoid arthritis (RA) but not well investigated in Axial spondylitis (AxSpA). DCs are a heterogeneous population and can be divided into groups: myeloid (mDCs) and plasmacytoid (pDCs). DCs can induce both immune response and tolerance. Objectives: To investigate the subpopulations of peripheral blood myeloid and plasmacytoid DCs in patients with early stage of RA (duration of illness up to 12 months) and AS. Methods: The study include sixty five patients with early forms of diseases including 55 patients with RA and 10 patients with AxSpA. Diagnosis RA was established according ACR/EULAR criteria (2010). Diagnosis AxSpA was established according ASAS criteria. All patients received conventional synthetic DMARDs. Thirty patients with osteoarthritis (OA) used as a control group. Analysis of the content of the B-lymphocytes, myeloid and plasmacytoid DCs was carried out by flow cytometry. B-lymphocytes, subtypes of peripheral blood DCs were characterized by the following phenotypes: myeloid DCs (CD3-CD14-CD19-HLA-DR + CD11c + CD123-), plasmacytoid DCs (CD3-CD14-CD19-HLA-DR + CD11c-CD123 +), B-lymphocytes (CD19 +). Analyses were performed before treatment and after 3 and 6 months. Results: Patients with early RA are characterized by significant evaluation of the population of myeloid DCs in comparison of patients with osteoarthritis (25.3% vs 21.5, p=0.005). Furthermore, the difference was found in the number of cells with the phenotype B-lymphocytes: 5.7% vs 3.1%, p = 0.0007). No significant differences were observed in the number of plasmocytoid DCs. After 3 and 6 month of observation we detected reducing amount of myeloid DCs 26.7% vs 20.1% vs 16.4% respectively. Disease activity according to DAS28 droped to low (4.32 to3.06, p=0.03). Patients with AxSpA are characterized a lower mDCs levels in compared with RA (19.3% vs 26.7, p=0.07). After 6 month of investigation we detected decreasing mDCs (19.3% to 14.2%, p=0.05). The percent of pDCs were constant and did not differ from the level of healthy donors. Conclusion: The data obtained indicate that early form of rheumatic diseases namely rheumatoid arthritis and axial spondylitis have the common features such as the dominance of mDCs and their decreasing in reduction of activity of disease. Disclosure of Interests: None declared
使用LHCb实验记录的1.0 fb⁻¹积分亮度观测衰变过程

测量了分支比分数值，发现B̄s⁰→Ds⁺K⁻π⁺π⁻衰变可用于测量弱相位γ，并首次观测到B̄s⁰→Ds1(2536)⁺π⁻衰变
This work is devoted to determining of transport characteristics of a granular medium in an adsorber by the example of hollow glass microspheres and a composite sorbent on their basis. To carry out the research a special experimental stand was constructed to determine the transport characteristics for various gases at given pressure and temperature values in the adsorber. The technique of experiment and processing of experimental data for the purpose of determining transport characteristics of granular medium has been worked out. For microspheres of type MS-V-2L, MS-VP, MS-VP-A9 and composite sorbent based on microspheres MS-VP-A9 were determined the gas permeability of the granular medium, the propagation velocity of the pressure wave in a granular medium, the time of filling with gas of the adsorber containing microspheres or the composite sorbent.
We studied the level of spontaneous telomere dysfunction in Rattus norvegicus (Berkenhout, 1769) (Rodentia, Muridae) embryonic fibroblasts (rEFs) and in cultured in vitro rat pluripotent stem cells (rPSCs), embryonic stem cells (rESCs) and induced pluripotent stem cells (riPSCs), on early passages and after prolonged cultivation. Among studied cell lines, rESCs showed the lowest level of telomere dysfunction, while the riPSCs demonstrated an elevated level on early passages of cultivation. In cultivation, the frequency of dysfunctional telomeres has increased in all studied cell lines; this is particularly true for dysfunctional telomeres occurring in G1 stage in riPSCs. The obtained data are mainly discussed in the connection with the specific structure of the telomere regions and their influence on the differential DNA damage response in them.
The response of extra-tropical evergreen and deciduous Russian forest ecosystems to a wide range of atmospheric background conditions is considered.

This study is performed by using a land-surface model, JSBACH. Two numerical experiments are carried out: with hotter and more humid (model PLASIM) and more moderate (model INMCM4) atmospheric background conditions. A perturbation in the climate system is set by using the RCP 8.5 climate scenario.

The study has shown a geographical redistribution of the extra-tropical evergreen and deciduous forests across Russia as well as an increase in their fractions in some already forested regions. An increase in the gross and net CO2 assimilation and respiration of these types of forest vegetation, as their response to the climatic disturbances, is obtained. However, even under the conditions of extremely intense climatic disturbances the Russian forest ecosystems will continue to act as CO2 sinks.
Large device variation is a fundamental challenge for resistive random access memory (RRAM) array circuit. Improved device-to-device distributions of set and reset voltages in a SiNx RRAM device is realized via arsenic ion (As+) implantation. Besides, the As+-implanted SiNx RRAM device exhibits much tighter cycle-to-cycle distribution than the nonimplanted device. The As+-implanted SiNx device further exhibits excellent performance, which shows high stability and a large 1.73 × 103 resistance window at 85 °C retention for 104 s, and a large 103 resistance window after 105 cycles of the pulsed endurance test. The current–voltage characteristics of high- and low-resistance states were both analyzed as space-charge-limited conduction mechanism. From the simulated defect distribution in the SiNx layer, a microscopic model was established, and the formation and rupture of defect-conductive paths were proposed for the resistance switching behavior. Therefore, the reason for such high device performance can be attributed to the sufficient defects created by As+ implantation that leads to low forming and operation power.
Our analysis is based on a data set of $(772\pm 11)\times 10^{6}$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^+e^-$ collider.

We measure the absolute branching fraction of $\bar{B}^{0} \to \bar{\Lambda}_{c}^{-} \Xi_{c}^{+}$ with the $\Xi_c^+$ recoiling against $\bar{\Lambda}_c^-$ in $\bar{B}^0$ decays. We then measure the product branching fractions ${\cal B}(\bar{B}^{0} \to \bar{\Lambda}_c^- \Xi_c^+){\cal B}(\Xi_c^+ \to \Xi^- \pi^+ \pi^+)$ and ${\cal B}(\bar{B}^{0} \to \bar{\Lambda}_c^- \Xi_c^+){\cal B}(\Xi_c^+ \to p K^- \pi^+)$.

Dividing these product branching fractions by $\bar{B}^{0} \to \bar{\Lambda}_{c}^{-} \Xi_{c}^{+}$ yields: ${\cal B}(\Xi_c^+ \to \Xi^- \pi^+ \pi^+) = [2.86 \pm 1.21(\rm stat.) \pm 0.38(\rm syst.)]\%$ and ${\cal B}(\Xi_c^+ \to p K^- \pi^+)=[0.45 \pm 0.21(\rm stat.) \pm 0.07(\rm syst.)]\%$. Our result for ${\cal B}(\Xi_c^+ \to \Xi^- \pi^+ \pi^+)$ can be combined with $\Xi_c^+$ branching fractions measured relative to $\Xi_c^+ \to \Xi^- \pi^+ \pi^+$ to set the absolute scale for many $\Xi_c^+$ branching fractions.
The article is devoted to research of features of mythological model, which is reflected in the late journalism of Valentin Rasputin. The complex of interconnected myths is revealed, their historical roots are traced. The eschatological myth is considered; the author shows that the messianic idea of Russia’s unique role in the world is accompanied by the construction of the enemy image. Images of internal enemies (liberals) and external enemies (Europe and America) are demonized. The eschatological experiences of the crisis moments of “adjustment period” and the beginning of the 21st century are accompanied by utopian nostalgia for the “Golden Age”, which the writer saw in the historical background of Russia, particularly in the Soviet era. The article considers Rasputin’s utopian idea of power and the government leader. Denying liberal values, the writer asserts the idea of a strong ruler, whose main function is to “fulfill God’s laws”. Stalin is recognized as an example of a leader who expressed the «national spirit». Rasputin’s mythology has common features with the concept of “Third Rome” and with some categories of Old Russian autocratic ideology of the 16th century, as well as with the ideas of Old Believers. The article traces the ways of constructing the author’s myth. The writer’s mythology is based on non-critical use of concepts and myths and is based on archetypes of national mythology. Besides, the writer constructs the myth with the help of language tools, creating neologisms and using estimation vocabulary. Rasputin's mythological model reflects the conceptual core of conservative ideology.
In 2021, the Sagai archaeological team of the Institute of Archeology and Ethnography SB RAS excavated four funerary and memorial complexes in the construction zone of the «Second track on the Chаrtykovsкy - Kamyshta stretch of the Krasnoyarsk railway». Mound 2 of the Sagayskaya protoka 2 burial ground contained 11 graves. Traces of diverse funeral rites were noted: intact corpses and partial burials of adults and infants in stone boxes and ground pits without stone structures. The grave inventory is poor - vessels and two iron objects (a knife and a buckle). Petroglyphic images were noted on the slabs of the boxes. Among them, there is a composition of the battle of two warriors, one of whom is on skis. At the site of the “Single kurgan Sagayskaya protoka 5”, Tesinsky graves 1 and 3 were made in the stone ceiling of the Saragash grave. In grave 1, two adults were buried. A partial burial (grave 2) was found at some distance. The burials are tentatively dated to the range of the 1st century BC - 1st century AD. In addition to the burials, an excavation trench was established revealing cultural layer containing roughly made stone tools from river pebbles, fragments of animal bones and ceramic vessels with ornaments typical for the Tashtyk pottery. In the areas associated with burial mound 6 (burial site Sagayskaya protoka 2) and burial mounds 1 and No. 2 (burial ground Sagayskaya protoka 8), 39 cult sites were recorded. By their construction, the sites can be classified into several groups: ground pits with animal bones and vessels under the stone work ceiling; ground pits with the remains of wooden posts; ground pits filled with rubble stones; slabs with the edge dug in the ground or tumbled down. The features of the ceramics make it possible to attribute the graves to the Tashtyk culture.