Hengzongshu/ArticleAgent huggingface dataset:
We report on an extension of the quasi-resonance (QUASR) pulse sequence used for signal amplification by reversible exchange (SABRE), showing that we may target distantly J-coupled 19F-spins.

Polarization transfer from the parahydrogen-derived hydrides to the 19F nucleus is accomplished via weak five-bond J-couplings using a shaped QUASR radio frequency pulse at a 0.05 T magnetic field. An accumulation of 19F polarization on the free ligand is achieved with subsequent repetition of this pulse sequence. The hyperpolarized 19F signal exhibits clear dependence on the pulse length, irradiation frequency, and delay time in a manner similar to that reported for 15N QUASR-SABRE.

The net result is the direct generation of hyperpolarized 19F z-magnetization, derived from the parahydrogen singlet order. Moreover, the hyperpolarized 19F signals of 3-19F-14N-pyridine and 3-19F-15N-pyridine isotopologues are similar, suggesting that (i) polarization transfer via QUASR-SABRE is irrespective of the nitrogen isotopologue and (ii) the presence or absence of the spin-1/2 15N nucleus has no impact on the efficiency of QUASR-SABRE polarization transfer. Although optimization of polarization transfer efficiency to 19F (P19F ≈ 0.1%) was not the goal of this study, we show that high-field SABRE can be efficient and broadly applicable for direct hyperpolarization of 19F spins.
A bstract The production of B ± mesons in proton-proton collisions at $ \sqrt {s} $ = 7 TeV is studied using 35 pb −1 of data collected by the LHCb detector. The B ± mesons are reconstructed exclusively in the B ± → J/ψK ± mode, with J/ψ → μ + μ − . The differential production cross-section is measured as a function of the B ± transverse momentum in the fiducial region 0 < p T < 40 GeV / c and with rapidity 2 . 0 < y < 4 . 5. The total cross-section, summing up B + and B − , is measured to be σ ( pp → B ± X, 0 < p T < 40 GeV / c , 2 . 0 < y < 4 . 5) = 41 . 4 ± 1 . 5 (stat . ) ± 3 . 1 (syst . ) μb .
Propagation of high-intensity, high-contrast (<10−8), 50 fs laser pulses through triangular copper capillaries is experimentally studied.

The relative transmission through 20-mm-long, about 50 μm wide capillaries is directly measured to be 70% for input intensities up to 1017 W/cm2. The copper reflectivity in vacuum, helium, and air is measured in the intensity range of 1010–1017 W/cm2. The dependence of the capillary lifetime on the pulse energy is measured.

No reflectivity decrease in vacuum and helium is observed, which leads to the conclusion that copper capillary waveguides can efficiently guide laser pulses of intensities greater than 1019 W/cm2 on the capillary axis (that corresponds to 1017 W/cm2 on the walls). The reduction of the transmission efficiency to zero after a number of transmitted pulses is observed, which is caused by plug formation inside the capillary.
The article deals with the study of interrelation of trace elements and morphology of lymph nodes at different localization and age-related changes.

Lymph nodes of different localization at young and old animals were analyzed by a morphological method with definition of trace elements by roentgen fluorescent method and the use of synchrotron radiation.

There are data on forming of the lymphoid-microelement association important for integrative assessment of the structural organization of lymph nodes. Structural modification of lymph nodes has certain patterns, proceeding from features of a microelement profile. The region-dependent morphological variant of lymph nodes corresponds to a certain content of trace elements and their correlation with compartments of lymph nodes. Trace elements deficiency and reduction of compartments of lymph nodes are considered as predictors of aging of lymphoid tissue. The results have practical significance to justify a higher traceelement content in anti-aging programs.
Computational analysis of gene regulatory regions is important for prediction of functions of many uncharacterized genes. With this in mind, search of the target genes for interferon (IFN) induction appears of interest. IFNs are multi-functional cytokines. Their effects are immunomodulatory, antiviral, antibacterial, and antitumor. The interaction of the IFNs with their cell surface receptors produces an activation of several transcription factors. Four regulatory factors, ISGF3, STAT1, IRF1, and NF-κB, are essential for the function of the IFN system. The aim of this work is the development of computational approaches for the recognition of DNA binding sites for these factors and computer programs for the prediction of the IFN-inducible regions. We developed computational approaches to the recognition of the binding sites for ISGF3, STAT1, IRF1, and NF-κB. Analysis of the distribution of these binding sites demonstrated that the regions -500 upstream of the transcription start site in IFN-inducible genes are enriched in putative binding sites for these transcription factors. Based on selected combinations of the sites whose frequencies were significantly higher than in the other functional gene groups, we developed methods for the prediction of the IFN-inducible promoters and enhancers. We analyzed 1004 sequences of the IFN-inducible genes compiled using microarray data analyses and also about 10,000 human gene sequences from the EPD and RefSeq databases; 74 of 1,664 human genes annotated in EPD were significantly IFN-inducible. Analyses of several control datasets demonstrated that the developed methods have a high accuracy of prediction of the IFN-inducible genes. Application of these methods to several datasets suggested that the number of the IFN-inducible genes is approximately 1500–2000 in the human genome.
The Klyuchevskoy Volcanic Group is a cluster of the world's most active subduction volcanoes, situated on the Kamchatka Peninsula, Russia. The volcanoes lie in an unusual off‐arc position within the Central Kamchatka Depression (CKD), a large sedimentary basin whose origin is not fully understood. Many gaps also remain in the knowledge of the crustal magmatic plumbing system of these volcanoes.

We conducted an ambient noise surface wave tomography, to image the 3‐D shear wave velocity structure of the Klyuchevskoy Volcanic Group and CKD within the surrounding region. Vertical component cross correlations of the continuous seismic noise are used to measure interstation Rayleigh wave group and phase traveltimes. We perform a two‐step surface wave tomography to model the 3‐D Vsv velocity structure. For each inversion stage we use a transdimensional Bayesian Monte Carlo approach, with coupled uncertainty propagation. This ensures that our model provides a reliable 3‐D velocity image of the upper 15 km of the crust, as well as a robust assessment of the uncertainty in the observed structure.

Beneath the active volcanoes, we image small slow velocity anomalies at depths of 2–5 km but find no evidence for magma storage regions deeper than 5 km—noting the 15 km depth limit of the model. We also map two clearly defined sedimentary layers within the CKD, revealing an extensive 8 km deep sedimentary accumulation. This volume of sediments is consistent with the possibility that the CKD was formed as an Eocene‐Pliocene fore‐arc regime, rather than by recent (<2 Ma) back‐arc extension.
The article is based on the writings of Andrei Borisov, an Old Believer, head of the Vyg community from 1780 to 1791. The article is devoted to the problem of the connection of Old Believer culture with the general Russian cultural context. The author develops a view of Andrei Borisov as a person who, according to R.O.Crammey, 'lived in two cultural worlds'.

The author draws attention to the fact that the works of this writer reflected commonplaces and key concepts of not only the Russian Enlightenment, but also sentimentalism. Sentimentalism in Russia was the result of the literary culture of the 18 th century, the logical conclusion of the Enlightenment program. Anthropocentricity, which was characteristic of the aesthetic program of Russian sentimentalism, was reflected in the image of the author. The author in the works of Andrei Borisov is not a conditional rhetorical image. New ways of representing the personality of the leader of the Old Believer community, who appears as an ordinary person endowed with the ability to feel and empathize, even experience physical pain, are shown. Rationality is combined in the image of the author with emotionality and moralism, this is a real person, a being as emotional as moral and thinking about civic duty ('Regrettable Behavior', The Life of Andrei Denisov and other works). The article shows that Andrei Borisov focused on the problem of morality. The key category in his work is 'virtue'. Virtue was the most important concept in the program of Russian sentimentalism. From the standpoint of morality and virtue, Andrei Borisov even solved polemical problems (the problem of prayer for the emperor), he argued that secular morality and virtue are more important than correct faith, and that is why Old Believers can pray for the emperor. The article notes the closeness of the work of Andrei Borisov to the official church sermon of the late 18th century. Andrei Borisov's contemporary, Metropolitan Plato (Levshin, Metropolitan since 1787), in his sermons interpreted the Enlightenment as a virtue, in his texts morality and feeling are put in the first place, as in sentimentalism.

Thus, the style of the era extends not only to secular literature and art, but also to church preaching, and to Old Believer creativity of the late 18 th century. The article offers new arguments in favor of the view that the Old Believer culture was part of Russian culture, and not a self-sufficient island of traditionalism, isolated from a changing society.
To evaluate the clinical symptoms in pancreatic cancer patients (PCa) and compare some biochemical blood serum parameters in patients with different pathology of the pancreas (PCa, acute (OP) and chronic pancreatitis (CP)).

During a one-time clinical research on the type of 'series of cases' 130 patients were examined (42 patients with OP, 81 – CP and 7 patients with PCa). The diagnosis of PCa, OP, CP was verified by clinical and instrumental methods. Glucose, cholesterol, triglyceride and bilirubin serum levels were determined by ELISA.

The level of glucose in PCa patients exceeded the normal limits and was significantly higher compared to that in OP and CP patients. However, the total cholesterol in CP patients was significantly higher than that in PCa and OP patients. The combination of nonspecific clinical signs (pain, dyspepsia) with biochemical markers of biliary pathology and endocrine pancreatic insufficiency – of PCa patients demonstrates the obligatoriness of differential diagnostic pancreatic and biliary pathology in their earlier stages.
Visualisation of complex nonlinear equation solutions is a useful analysis tool for various scientific and engineering applications. We have re-examined the geometrical interpretation of the classical nonlinear four-wave mixing equations for the specific scheme of a phase sensitive one-pump fiber optical parametric amplification, which has recently attracted revived interest in the optical communications due to potential low noise properties of such amplifiers. Analysis of the phase portraits of the corresponding dynamical systems provide valuable additional insight into field dynamics and properties of the amplifiers. Simple geometric approach has been proposed to describe evolution of the waves, involved in phase-sensitive fiber optical parametric amplification (PS-FOPA) process, using a Hamiltonian structure of the governing equations. We have demonstrated how the proposed approach can be applied to the optimization problems arising in the design of the specific PS-FOPA scheme. The method considered here is rather general and can be used in various applications.
Disassembly and reassembly of the nuclear pore complexes (NPCs) is one of the major events during open mitosis in higher eukaryotes. However, how this process is controlled by the mitotic machinery is not clear. To investigate this we developed a novel in vivo model system based on syncytial Drosophila embryos. We microinjected different mitotic effectors into the embryonic cytoplasm and monitored the dynamics of disassembly/reassembly of NPCs in live embryos using fluorescently labeled wheat germ agglutinin (WGA) or in fixed embryos using electron microscopy and immunostaining techniques. We found that in live embryos Cdk1 activity was necessary and sufficient to induce disassembly of NPCs as well as their cytoplasmic mimics: annulate lamellae pore complexes (ALPCs). Cdk1 activity was also required for keeping NPCs and ALPCs disassembled during mitosis. In agreement recombinant Cdk1/cyclin B was able to induce phosphorylation and dissociation of nucleoporins from the NPCs in vitro. Conversely, reassembly of NPCs and ALPCs was dependent on the activity of protein phosphatases, sensitive to okadaic acid (OA). Our findings suggest a model where mitotic disassembly/reassembly of the NPCs is regulated by a dynamic equilibrium of Cdk1 and OA-sensitive phosphatase activities and provide evidence that mitotic phosphorylation mediates disassembly of the NPC.
In this study, n-type MoS2 monolayer flakes are grown through chemical vapor deposition (CVD), and a p-type Cu2O thin film is grown via electrochemical deposition.

The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2 flakes is verified with Raman spectroscopy, multiphoton excitation microscopy, atomic force microscopy, and photoluminescence (PL) measurements. After the preliminary processing of the grown MoS2 flakes, the sample is then transferred onto a Cu2O thin film to complete a p-n heterogeneous structure. Data are confirmed via scanning electron microscopy, SHG, and Raman mapping measurements. The luminous energy gap between the two materials is examined through PL measurements.

Results reveal that the thickness of the single-layer MoS2 film is 0.7 nm. PL mapping shows a micro signal generated at the 627 nm wavelength, which belongs to the B2 excitons of MoS2 and tends to increase gradually when it approaches 670 nm. Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. By measuring the slope of the photocurrent, we can identify the type of cells and the number of cells.
Ballas diamond is a rare form of the polycrystalline radial aggregate of diamonds with diverse internal structures. The morphological features of ballas diamonds have experienced repeated revision. The need that this paper presents for development of a crystal-genetic classification was determined by a rich variety of combined and transitional forms of ballas-like diamonds, which include aggregates, crystals, and intergrowths. The new crystal-genetic classification combines already-known and new morphological types of ballas as well as ballas-like diamonds discovered in the placers of Yakutia, the Urals, and Brazil. The ballas-like diamond forms include spherocrystals, aggregates with a single crystal core, split crystals, radial multiple twin intergrowths, and globular crystals. The crystal genetic scheme of the evolution of ballas and ballas-like diamonds is a sequence of the morphological types arranged in accordance with the conventional model of the dependence of the mechanism and diamond growth from carbon supersaturation developed by I. Sunagawa. The evolution of the growth forms of ballas and ballas-like diamonds was tracked based on the macrozonal structure of diamonds varying from a flat-faced octahedron to a fibrous cuboid with its transition forms to the radiating crystal aggregates. The morphological diversity of the ballas-like diamonds depends on the level of supersaturation, and abrupt changes of the level of supersaturation engender abrupt changes in a mechanism of crystal growth. The change in the rate of growth under the influence of adsorption and absorption of the mechanic impurities accompanied the sudden appearance of the autodeformation defects in the form of splitting and multiple radial twinning of crystals. The spherical shape of Yakutia ballas-like diamonds is due to the volumetric dissolution that results in the curved-face crystals of the “Urals” or “Brazilian” type associated with ballas diamonds in placers.
基于在KEKB不对称能量电子-正电子对撞机的Belle探测器上收集的7.72亿B对数据样本，在Υ(4S)共振处

本研究使用了基于神经网络的有介子B介子标记方法

测量到B-→pp̅ℓ-ν̅ℓ的分支比为(5.8+2.4-2.1(stat.)±0.9(syst.))×10-6，显著性为3.2σ，其中假设了轻子普适性。我们还估计了相应的上限：在90%置信水平下B(B-→pp̅ℓ-ν̅ℓ) < 9.6×10-6。该测量有助于约束B衰变中的重子跃迁形状因子
Direct model-independent relation between the secular perihelion precession of a planet and the density of dark matter ρ dm at its orbit is indicated

used to deduce upper limits on local values of ρ dm
Repeated experience of winning in a social conflict setting elevates levels of aggression and may lead to violent behavioral patterns.

Here, we use a paradigm of repeated aggression and fighting deprivation to examine changes in behavior, neurogenesis, and neuronal activity in mice with positive fighting experience. We show that for males, repeated positive fighting experience induces persistent demonstration of aggression and stereotypic behaviors in daily agonistic interactions, enhances aggressive motivation, and elevates levels of anxiety. When winning males are deprived of opportunities to engage in further fights, they demonstrate increased levels of aggressiveness. Positive fighting experience results in increased levels of progenitor cell proliferation and production of young neurons in the hippocampus. This increase is not diminished after a fighting deprivation period. Furthermore, repeated winning experience decreases the number of activated (c-fos-positive) cells in the basolateral amygdala and increases the number of activated cells in the hippocampus; a subsequent no-fight period restores the number of c-fos-positive cells.

Our results indicate that extended positive fighting experience in a social conflict heightens aggression, increases proliferation of neuronal progenitors and production of young neurons in the hippocampus, and decreases neuronal activity in the amygdala; these changes can be modified by depriving the winners of the opportunity for further fights.
Определена локализация 10 новых генов на X хромосомах пяти видов серых полевок рода Шсгоаи. Особенностью выбранных генов является их свойство избегать инактивации на инактивируемой X хромосоме человека и, частично, мыши.

На основе сравнительного анализа локализации генов на X хромосомах четырех видов полевок группы алю/й (обыкновенные полевки) выявлены четыре новые и уточнены границы двух определенных ранее инверсий.

Обнаружено семь кластеров консервативной синтении в X хромосомах обыкновенных полевок, В результате сравненияпорядка генов у полевок группы ап/аИя и представителя внешней группы огг«*й показано, что X хромосомы М. опта/и и М
In this paper we will present the results of Artin–Markov on braid groups

by using the Gröbner–Shirshov basis

As a consequence we can reobtain the normal form of Artin–Markov–Ivanovsky as an easy corollary
The work is devoted to the calculation of gas flow and modeling of droplet sedimentation of medicinal aerosols in human lungs. To solve this problem, a previously constructed three-dimensional model of a human bronchial tree was used. For calculation of gas flow in lungs and aerosol deposition the method of step-by-step calculation of the flow in bronchial tree was used. It allowed to calculate the air flow and aerosol droplets deposition in all bronchial branches up to alveolus. Human breathing was calculated using COVID-19 thermal helium-oxygen mixture treatment method. Breathing with a thermal helium-oxygen mixture requires less effort from the patient than breathing with air. Three-dimensional numerical calculations of air flow and aerosol droplets in human lungs have been performed. The characteristics of a serial medical nebulizer were used to calculate the deposition of aerosol droplets. It is shown that the number of past droplets depends (except for flow, droplet size) on the duration of breath. The nebulizer under consideration does not provide delivery of medicines to the lung alveolus.
Отраслевые правовые доктрины остро нуждаются в формировании устойчивой конституционно-правовой позиции как метаюридической, ценностной основы, позволяющей сгенерировать императивы отраслевого правотворчества и правореализации.В науке финансового права актуальными являются такие проблемы, как определение предметно-методологической составляющей отрасли, формирование ее системы и др.

В поиске решений обозначенных проблем автор статьи предлагает обратиться к исследованию метаюридической сущности финансового права, используя категорию достоинства личности как экзистенциальной ценности, проникающей в национальное право и претендующей на статус принципа права, комплексного межотраслевого института и субъективного права.

В этих целях рассмотрено развитие легитимации и легализации данной категории, ее влияние на финансово-правовое регулирование, выделены особенности финансового права и его роль в формировании комплексного межотраслевого института достоинства личности в национальном законодательстве
We study the processes e+e−→π+π−π0π0π0γ and π+π−π0π0ηγ in which an energetic photon is radiated from the initial state. The data are collected with the BABAR detector at SLAC. About 14 000 and 4700 events, respectively, are selected from a data sample corresponding to an integrated luminosity of 469 fb−1. The invariant mass of the hadronic final state defines the effective e+e− center-of-mass energy. From the mass spectra, the first precise measurement of the e+e−→π+π−π0π0π0 cross section and the first measurement ever of the e+e−→π+π−π0π0η cross section are performed. The center-of-mass energies range from threshold to 4.35 GeV. The systematic uncertainty is typically between 10% and 13%. The contributions from ωπ0π0, ηπ+π−, and other intermediate states are presented. We observe the J/ψ and ψ(2S) in most of these final states and measure the corresponding branching fractions, many of them for the first time.30 MoreReceived 30 October 2018DOI:https://doi.org/10.1103/PhysRevD.98.112015Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasParticle interactionsParticle productionParticles & Fields
Hydraulic fracturing is a technology that is widely used in the development of oil and gas formations. Given that the fracture closure has a strong impact on production, quantifying the resulting fracture conductivity is critical for optimizing treatment design.

The goal of this paper is to better understand the influence of the closing stress on the fracture conductivity when the proppant distribution is heterogeneous. In addition to the spatial proppant distribution, the conductivity of the propped fracture is affected by proppant deformation and embedment.

Numerical results indicate that compressibility of proppant can significantly change the residual fracture aperture and, consequently, production performance in oil and gas reservoirs.