Hengzongshu/ArticleAgent huggingface dataset:
We present an analysis of the semi-inclusive decays $B_s \to D_s^- X \ell^+ \nu$ and $B_s \to D_s^{*-} X \ell^+ \nu$, where $X$ denotes a final state that may consist of additional hadrons or photons and $\ell$ is an electron or muon.

The studied $B_s$ decays are contained in the $121.4~{\rm fb}^{-1}$ $\Upsilon(5S)$ data sample collected by the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider.

The branching fractions of the decays are measured to be $\mathcal{B}(B_s \to D_s^- X \ell^+ \nu) = [8.2 \pm 0.2 (\text{stat}) \pm 0.6 (\text{syst}) \pm 1.4 (\text{ext})]\%$ and $\mathcal{B}(B_s \to D_s^{*-} X \ell^+ \nu) = [5.4 \pm 0.4 (\text{stat}) \pm 0.4 (\text{syst}) \pm 0.9 (\text{ext})]\%$, where the first two uncertainties are statistical and systematic and the last is due to external parameters. The measurement also provides an estimate of the $B_s^{(*)}\bar{B}_s^{(*)}$ production cross-section, $\sigma(e^+e^- \to B_s^{(*)}\bar{B}_s^{(*)}) = (53.8 \pm 1.4 (\text{stat}) \pm 4.0 (\text{syst}) \pm 3.4 (\text{ext}))\,{\rm pb}$, at the center-of-mass energy $\sqrt{s} = 10.86\,{\rm GeV}$.
We performed direct numerical simulations of the annular turbulent jet flow for the Reynolds number based on the bulk velocity inside the nozzle and its outer diameter Re = 8900 with three different values of the inner-to-outer diameter ratio a = d / D = 0.3, 0.5, 0.7. The size of the reversal flow region, the fluctuation level and mixing rate increase with the increase of the diameter ratio. For all the cases of geometry parameters the symmetry breaking phenomenon was detected. The degree of asymmetry increases with the increase of the diameter ratio resulting in the displacement of the global stagnation points form the axis of symmetry and the deflection of the averaged streamlines from the jet axis.
The SARS-CoV-2 is the third coronavirus in addition to SARS-CoV and MERS-CoV that causes severe respiratory syndrome in humans. All of them likely crossed the interspecific barrier between animals and humans and are of zoonotic origin, respectively. The origin and evolution of viruses and their phylogenetic relationships are of great importance for study of their pathogenicity and development of antiviral drugs and vaccines. The main objective of the presented study was to compare two methods for identifying relationships between coronavirus genomes: phylogenetic one based on the whole genome alignment followed by molecular phylogenetic tree inference and alignment-free clustering of triplet frequencies, respectively, using 69 coronavirus genomes selected from two public databases. Both approaches resulted in well-resolved robust classifications. In general, the clusters identified by the first approach were in good agreement with the classes identified by the second using K-means and the elastic map method, but not always, which still needs to be explained. Both approaches demonstrated also a significant divergence of genomes on a taxonomic level, but there was less correspondence between genomes regarding the types of diseases they caused, which may be due to the individual characteristics of the host. This research showed that alignment-free methods are efficient in combination with alignment-based methods. They have a significant advantage in computational complexity and provide valuable additional alternative information on the genomes relationships.
Hemozoin is the pigment produced by some blood-feeding parasites. It demonstrates high diagnostic and therapeutic potential. In this work the formation of co-called hemozoin "knobs" – the bile duct ectasia filled up by hemozoin pigment - in Opisthorhis felineus infected hamster liver has been observed. The O. felineus infected liver was examined by histological analysis and magnetic resonance imaging (MRI). The pigment hemozoin was identified by Fourier transform infrared spectroscopy and high resolution electrospray ionization mass spectrometry analysis. Hemozoin crystals were characterised by high resolution transmission electron microscopy. Hemozoin crystals produced by O. felineus have average length 403 nm and the length-to-width ratio equals 2.0. The regurgitation of hemozoin from parasitic fluke during infection leads to formation of bile duct ectasia. The active release of hemozoin from O. felineus during in vitro incubation has also been evidenced. It has been shown that the hemozoin knobs can be detected by magnetic resonance imaging. In the paper for the first time the characterisation of hemozoin pigment extracted from liver fluke O. felineus has been conducted. The role of hemozoin in the modification of immune response by opisthorchiasis is assumed.
A practical numerical method for the effective solution of the Thomson Problem is proposed.

The developed iterative algorithm allows to conduct theoretical researches such as study of the number of asymptotic solutions depending on the particle count. Metastable states of charged point systems on a unit sphere were considered and the probability of falling into the basin of each state was obtained.

Founded upon the algorithm and dual lattice representation approach, the framework for rapid construction of capped carbon nanotubes was created.
The article presents an analysis of the performance indicators of oil and gas companies, justification of the choice the most appropriate indicators for different company comparison. The author made and introduced indicators’ classification according to various criteria: in the form of expression, depending on the object of study and others. To compare companies, you can not use indicators which were counted by these companies because of the different structure of indicators.

In this case, you need to count all indexes by your own using financial reports to make a united structure. The aim of the work is evaluation of the efficiency of companies of oil and gas complex and making a factor analysis of indicators of efficiency. To fulfill the goal author used formulas for counting indicators.

One of the results of this work is that ROE (Return On Equity) is one of the most important and representative indexes because it shows how effective money of shareholders is used. It has a sense because all analyzed companies are joint-stock. Using a decomposition and factor analysis of ROE author showed that with an increase in net profit and equity at the same percentage, the return on equity is more sensitive to changes in net profit. And in the situation of decreasing the same elements, ROE is more sensitive to changes in equity.
2 Федеральное государственное бюджетное научное учреждение «Научно-
The aim of the study was to examine age-related changes in the ultrastructure of synapses in the CA1 region of the hippocampus of Wistar rats and premature aging OXYS rats.

To assess changes of the sinaptoarhitectonics photographed on 15 randomly chosen fields of view of the pyramidal layer of the CA1 region of the hippocampus with five slices at a standard magnification of 10000. It was determined the amount of mineral contacts (size of the field of view is 50 μm2) and calculated numerical density of synapses per 100 μm 2 . The number of contacts with asymmetric and symmetric organization sistemasubsidiaries units, perforated, hypertrophic contacts are counted.

The study showed that there are significant differences in the ultrastructural organization of the synapses between the lines, already 4 months old. The numerical density of snaps in this age group OXYS rats was significantly higher than that of Wistar. Ultrastructure of synapses in the CA1 region of the hippocampus of rats at the age of 18 months more bulupodadan pathological essentiaompetencies processes and membrane prematurely senescent rats in contrast to the control line. The numerical indicator of protect contents 18-month-old rats OXYS was significantly lower than in Wistar. Identified interstrain differences in the degree of changes of synapses can testify in favor of a different sensitivity to oxidative stress in rats investigated lines.
In the paper [13], for an arbitrary virtual link [Formula: see text], three groups [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] were defined.

In the present paper, these groups for the virtual trefoil are investigated. The structure of these groups are found out and the fact that some of them are not isomorphic to each other is proved. Also, we prove that [Formula: see text] distinguishes the Kishino knot from the trivial knot. The fact that these groups have the lower central series which does not stabilize on the second term is noted.

Hence, we have a possibility to study these groups using quotients by terms of the lower central series and to construct representations of these groups in rings of formal power series. It allows to construct an invariants for virtual knots.
A novel scheme is presented for production of a thin ($100$ cm$^2$) by pulsed laser ablation of a solid surface. Instead of dispersing the laser energy uniformly over the surface, a modified Fabry-Perot interferometer is employed to concentrate the laser energy in very narrow closely-spaced concentric rings. This approach may be optimized to minimum total laser energy for the desired vapor density. Furthermore, since the vapor is produced from a small fraction of the total surface area, the local ablation depth is large, which minimized the fraction of surface contamination in the vapor. Key words: laser evaporation, thin gas layer formation.
The effect of heat stress (38°C) on the content of DL-β-(3,4-dihydroxyphenyl)alanine (DOPA), dopamine, tyramine, octopamine, and their precursor Tyr was studied in adults of two lines of Drosophila virilis contrasting in their stress response.

In individuals of line 101 responding to stress by a hormonal stress reaction, the contents of DOPA, dopamine, octopamine, and Tyr were lower than those of line 147 that did not respond to the stress.

However, heat stress caused an increase in the contents of DOPA, dopamine, octopamine, and Tyr in line 101, whereas the equivalent titers in line 147 remain unchanged.
The development of special autoclaves with automatic temperature control (Nikolaev Institute of Inorganic Chemistry) had enabled reproduction of Lake Baikal tectonically active zone typical conditions (80°C, 5 MPa). This article describes in details the equipment developed and demonstrates some results obtained using the equipment. In series of thermobaric experiments on the cultivation of bottom sediment microbial communities, we have determined the microbial community potential to transform organic matter via the formation of dibenzothiophenes, tri- and monoaromatic steroids as well as petroleum biomarkers (retene and gammacerene). The particular bottom sediment geochemical environment associated with hydrocarbon discharge imply the composition of microbial communities and, hence, the organic matter transformation degree as well as a compound spectrum resulting from the destruction of organic matter under thermobaric conditions. The presence of microorganisms with an unusual metabolism suggests the promising potential for such studies both in application to Lake Baikal and worldwide.
This study was carried out through 2010-2014, seasons on on …fresh herbs of Plantago major plant, which was collected from a private nurseries of El Qanater el Khayreyya, Al- Qaluobia Governorate, Egypt. The aim of this study was to investigate the protective potential of ethanolic crud extract of Plantago major against oxidative stress induced by carbon tetrachloride (CCl4) in different tissues in rats. Our results observed that CCl4 exhibited a significant increase in the levels of serum glucose and lipid profile i.e. total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL) with a significant decrease in the level of high density lipoprotein cholesterol (HDL). Also, CCl4 increase liver function including serum aminotransferases (AST and ALT), alkaline phosphatase (ALPh), total protein, albumin (ALB) and total bilirubin activities and kidney function including the levels of serum urea, uric acid and creatinine amounts. Treatment with ethanolic P. major extract at 100mg/kg b.wt before, with and after treatment with CCl4 significantly prevented all of these typically observed changes . Also, P. major extract statistically significant (P<0.01) inhibit DNA damage induced by CCl4 in bone marrow and sperms of rats. Our findings indicate that P. major has a significant protective effect against CCl4 induced genotoxicity and biochemical changes in rat, which may be due to its antioxidant properties.
Weaning from cardiopulmonary bypass (CPB) is a critical step of any cardiac surgical procedure and often requires pharmacologic intervention. Calcium ions are pivotal elements for the excitation-contraction coupling process of cardiac myocytes. Thus, calcium administration might be helpful during weaning from CPB.

We describe a multicenter, placebo-controlled, double blind randomized clinical trial to assess the effect of calcium chloride on the need for inotropic support among adult patients during weaning from CPB. The experimental group (409 patients) will receive 15 mg/kg of calcium chloride. The control group (409 patients) will receive an equivalent volume of 0.9% sodium chloride. Both drugs will be administered intravenously as a bolus at the beginning of weaning from CPB.

This trial is designed to assess whether intravenous calcium chloride administration could reduce the need for inotropic support after cardiopulmonary bypass weaning among adults undergoing cardiac surgery.
Complex dynamic tomographic experiments at brilliant X-ray light sources require real-time feedback on the sample changes with respect to environmental conditions, selecting representative regions of interest for high-resolution scanning, and on-demand data saving mechanisms for storing only relevant projections acquired by fast area detectors and reducing data volumes.

Here the implementation details of a 3D real-time imaging monitoring instrument, with zooming to a volume of interest with easy-to-use visualization via ImageJ, a tool familiar to most beamline users, is presented. The instrument relies on optimized data flow between the detector and processing machines and is implemented on commodity computers. The instrument has been developed at beamline 2-BM of the Advanced Photon Source, where the automatic lens changing mechanism for zooming is implemented with an Optique Peter microscope.

Performance tests demonstrate the ability to process more than 3 GB of projection data per second and generate real-time 3D zooming with different magnification. These new capabilities are essential for new APS Upgrade instruments such as the projection microscope under development at beamline 32-ID. The efficacy of the proposed instrument was demonstrated during an in situ tomographic experiment on ice and gas hydrate formation in porous samples.
In the 1940s, Karhunen and Loève proposed a method for processing a one-dimensional numeric time series by converting it into multidimensional by shifts. In fact, a one-dimensional number series was decomposed into several orthogonal time series. This method has many times been independently developed and applied in practice under various names (EOF, SSA, Caterpillar, etc.). Nowadays, the name 'SSA' (Singular Spectral Analysis) is the most often used. It turned out that it is universal, applicable to any time series without requiring stationary assumptions, automatically decomposes time series into a trend, cyclic components and noise. By the beginning of the 1980s, Takens had shown that for a dynamical system such a method makes it possible to obtain an attractor from observing only one of these variables, thereby bringing the method to a powerful theoretical basis. In the same years, the practical benefits of phase portraits became clear. In particular, it was used in the analysis and forecast of animal abundance dynamics.

In this paper we propose to extend SSA to a one-dimensional sequence of any type of elements, including numbers, symbols, figures, etc., and, as a special case, to a molecular sequence. Technically, the problem is solved using an algorithm like SSA. The sequence is cut by a sliding window into fragments of a given length. Between all fragments, the matrix of Euclidean distances is calculated. This is always possible. For example, the square root of the Hamming distance between fragments is a Euclidean distance. For the resulting matrix, the principal components are calculated by the principal-coordinate method (PCo). Instead of a distance matrix, one can use a matrix of any similarity/dissimilarity indexes and apply methods of multidimensional scaling (MDS). The result will always be PCs in some Euclidean space. We called this method 'PCA-Seq'.

It is certainly an exploratory method, as is its particular case SSA. For any sequence, including molecular, PCA-Seq without any additional assumptions allows presenting its principal components in a numerical form and visualizing them in the form of phase portraits. A long history of SSA application for numerical data gives all reason to believe that PCA-Seq will be not less useful in the analysis of non-numerical data, especially in hypothesizing. PCA-Seq is implemented in the freely distributed Jacobi 4 package (http://jacobi4.ru/).
Cryogenic Avalanche Detectors (CRADs) are referred to as a new class of noble-gas detectors operated at cryogenic temperatures with electron avalanching performed directly in the detection medium, the latter being in gaseous, liquid or two-phase (liquid-gas) state. Electron avalanching is provided by Micro-Pattern Gas Detector (MPGD) multipliers, in particular GEMs and THGEMs, operated at cryogenic temperatures in dense noble gases. The final goal for this kind of detectors is the development of large-volume detectors of ultimate sensitivity for rare-event experiments and medical applications, such as coherent neutrino-nucleus scattering, direct dark matter search, astrophysical (solar and supernova) neutrino detection experiments and Positron Emission Tomography technique. This review is the first attempt to summarize the results on CRAD performances obtained by different groups. A brief overview of the available CRAD concepts is also given and the most remarkable CRAD physics effects are discussed.
Finding novel biomarkers for human pathologies and predicting clinical outcomes for patients is challenging. This stems from the heterogeneous response of individuals to disease and is reflected in the inter-individual variability of gene expression responses that obscures differential gene expression analysis. Here, we developed an alternative approach that could be applied to dissect the disease-associated molecular changes. We define gene ensemble noise as a measure that represents a variance for a collection of genes encoding for either members of known biological pathways or subunits of annotated protein complexes and calculated within an individual. The gene ensemble noise allows for the holistic identification and interpretation of gene expression disbalance on the level of gene networks and systems. By comparing gene expression data from COVID-19, H1N1, and sepsis patients we identified common disturbances in a number of pathways and protein complexes relevant to the sepsis pathology. Among others, these include the mitochondrial respiratory chain complex I and peroxisomes. This suggests a Warburg effect and oxidative stress as common hallmarks of the immune host–pathogen response. Finally, we showed that gene ensemble noise could successfully be applied for the prediction of clinical outcome namely, the mortality of patients. Thus, we conclude that gene ensemble noise represents a promising approach for the investigation of molecular mechanisms of pathology through a prism of alterations in the coherent expression of gene circuits.
As the CsCl-type structure is considered as the model structure of the FeSi compound at the conditions of the Earth's core

On the basis of an unbiased structure prediction, it is shown that the stable form of NiSi under pressures of 100 and 200 GPa is the Pmmn structure. Furthermore, a new stable phase has been discovered: the deformed tetragonal CsCl-type structure with a = 2.174 Å and c = 2.69 Å at 400 GPa. Specifically, the sequence of high-pressure phase transitions is the following: the Pmmn structure below 213 GPa, the tetragonal CsCl type in the range 213–522 GPa, and cubic CsCl higher than 522 GPa.

this result implies restrictions on the Fe–Ni isomorphic miscibility in FeSi.
Karanahan, a cancer treatment technology aimed at eradicating tumor-initiating stem cells, has already proven effective in 7 tumor models. Karanahan comprises the following procedures: (1) collecting surgical specimens, (2) determining the duration of the DNA repair process in tumor cells exposed to a cross-linking cytostatic agent, and (3) determining the time point, when cells, including tumor-initiating stem cells, are synchronized in the certain phase of the cell cycle after triple exposure to the cytostatic, becoming vulnerable for the terminal treatment, which is supposed to completely eliminate the rest of survived tumor-initiating stem cells. Determining these basic tumor properties allows to design the schedule for the administration of a cross-linking cytostatic and a complex composite DNA preparation. Being conducted in accordance with the schedule designed, Karanahan results in the large-scale apoptosis of tumor cells with elimination of tumor-initiating stem cells.Breast tumor specimens were obtained from patients, and basic tumor properties essential for conducting Karanahan therapy were determined.We report the first use of Karanahan in patients diagnosed with breast cancer. Technical details of handling surgical specimens for determining the essential Karanahan parameters (tumor volume, cell number, cell proliferation status, etc) have been worked out. The terminally ill patient, who was undergoing palliative treatment and whose tumor specimen matched the required criteria, received a complete course of Karanahan.The results of the treatment conducted indicate that Karanahan technology has a therapeutic potency and can be used as a breast cancer treatment option.
The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to be discussed thoroughly. Unlike a single-trait scenario, multi-trait replication is not trivial considering the underlying genotype-multi-phenotype map of the associations. Here, we evaluate four methods for replicating multi-trait associations, corresponding to four levels of replication strength. Weak replication cannot justify pleiotropic genetic effects, whereas strong replication using our developed correlation methods can inform consistent pleiotropic genetic effects across the discovery and replication samples. We provide a protocol for replicating multi-trait genetic associations in practice. The described methods are implemented in the free and open-source R package MultiABEL.