Hengzongshu/ArticleAgent huggingface dataset:
The paper describes the experience of implementing a brand new interactive education platform at Novosibirsk State University (NSU). The purpose of the platform is to effectively use all potential communication channels between the object and the subject of knowledge in the system of higher professional education.

The modular exposition and education project "Archaeology of Eurasia" developed by the education and research centre "New Archaeology" includes material sources and several digital stands designed following modern trends in education, latest information technologies and many years of experience in teaching archaeology at NSU. The platform is based on primary principles of contemporary teaching approaches, such as brevity, imagery, diversity of sources, interactivity. The project applies interdisciplinary methodology, which includes the best achievements in the field of educational and information technologies and archaeological science.

Its active use in the educational process at the NSU Institute for the Humanities (IH) has shown to improve the quality of teaching and the level of learning skills. For the NSU IH this project is a new experience to transfer from the usual classroom to a fundamentally different learning environment which provides an endless variety of opportunities for teaching and learning. Combination of the virtual exposition and real exhibits provides the opportunity to find the optimal algorithm of the interaction between the visitor and the expositional and educational space.
A selective synthesis of 7‐ or 14‐nitrogen containing tricyclic diterpenoids was completed according to a strategy in which the key step was the catalyzed direct allylic amination of methyl 14α‐hydroxy‐15,16‐dihydroisopimarate with a wide variety of nitrogenated nucleophiles.

The catalyzed reaction of the mentioned diterpenoid allylic alcohol with 3‐nitroaniline, 3‐(trifluoromethyl)aniline, and 4‐(trifluoromethyl)aniline yield the subsequent 7α‐, 7β‐ and 14αnitrogen‐containing diterpenoids. The reaction with 2‐nitroaniline, 4‐nitro‐2‐chloroaniline, 4‐methoxy‐2‐nitroaniline, phenylsulfamide, or tert ‐butyl carbamate proceeds with the formation of 7α‐nitrogen‐substituted diterpenoids as the main products.

It was revealed that the selectivity of the reaction depends on the nature of nucleophile.
The hybrid Lattice Boltzmann method is adopted for a detailed study of surface wettability effects on evolution of vapor bubbles and temperature field of heat exchange surface at boiling.

The simulation results show that the bubble departure diameter increases with an increase of static contact angle, and its value normalized by the capillary length approaches 3 for superlyophobic surface. In the range of contact angles of 110° – 129° the size of the dry area bounded by triple contact line greatly increases compared to the bubble departure diameter. At contact angles θ ⩾ 153° the dry area does not shrink even at the bubble departure stage and the typical film boiling regime is observed. It has been shown that the deterioration of wettability affects the evolution of the temperature field beneath the bubble, which leads to a significant change in the local heat transfer rate.
The e+e- -> pi+pi-pi+pi- cross section has been measured using 5.8/pb of integrated luminosity collected with the CMD-2 detector at the VEPP-2M collider. Analysis of the data with a refined efficiency determination and use of both three- and four-track events allowed doubling of a data sample and reduction of systematic errors to 5-7%.
Due to global climate change and fossil fuel depletion, the rational use of thermal energy has attracted great research interest. Large differences between indoor and outdoor temperatures in cold regions results in huge amounts of heat waste and drop in indoor humidity. Ventireg, an adsorption method, has been often recommended for heat and humidity regeneration in cold countries.

In this research work, VentireC, an advanced method employing two thermally coupled adsorbent beds is discussed. It allows the heat released during adsorption of moisture in one adsorber to be transferred to another adsorber to facilitate water desorption. The VentireC approach is comprehensively analysed and described in this paper. A composite adsorbent based on LiCl in silica gel pores, which can exchange up to 0.5 g-H2O/g-sorbent, is selected for VentireC processes under cold Western Siberia conditions.

Mathematical simulation of humidity recuperation, employing the selected sorbent with and without thermal coupling, demonstrates the advantages of the VentireC process.
We report the experiment on a precise comparison of (e + p) and (e -p) elastic scattering cross sections, which gives a direct experimental evidence for the two-photon exchange contribution to this reaction.Such data are in demand now, because they, most likely, may explain the dramatic disagreement of proton electromagnetic form factors measurements in the polarization transfer experiments at TJNAF with previous unpolarized measurements using a Rosenbluth separation technique.Experiment was performed recently at VEPP-3 storage ring at the energy of positron/electron beams of 1.6 GeV and at e + /e -scattering angles around 20 • and 65 • .The preliminary results for the cross sections ratio R = σ (e + p)/σ (e -p) are presented.
Critical stresses for quasi-brittle bimaterial with edge cracks have been obtained. Cracks along the plane interface of the bimaterial are simulated as bilateral cuts.

The critical stresses correspond to necessary and sufficient fracture criteria and those are lower-bound and upper-bound estimates for critical states of a system. The embrittlement effect is revealed by comparison of fracture between bimaterial and homogeneous material. Estimates for effective diameters of grain separation have been obtained. It is noted that T -stress affects critical stresses for very short cracks, so for cracks occupying the most of a specimen width.

Critical stresses have been derived above which specimens are broken apart. Subareas on the plot of external load versus crack length are singled out where damage accumulation in material takes place after single loading. Comparison of critical stresses with the subareas mentioned above for homogeneous materials and bimaterials has been performed.
The aim of the study was to establish the association of the prevalence of coronary heart disease (CHD) and sleep disorders among men between the ages of 25 and 64 belonging to an open population of a medium-sized urban city of Western Siberia. Materials and methods . A cross-sectional epidemiological study was conducted on a representative sample of the population among males of 25–64 years old in Tyumen. The prevalence of coronary heart disease was determined based on standard epidemiological methods. Self-assessments by participants in the study of quality of sleep was determined by the World Health Organization (WHO) Monitoring Trends and Determinants in Cardiovascular Disease-Psychosocial Program (WHO MONICA-psychosocial). When calculating the odds ratio of developing coronary heart disease), self-reports of satisfactory, good, or very good sleep were regarded as a lack of an indicator; while very bad and bad sleep were considered positive indicators. Results. The prevalence of CHD according to the extended epidemiological criteria for men in an open urban population was 12.4%; the detection rate of “definite” and “possible” CHD was almost equal. The age-standardized prevalence rate of sleep disorders was 50.9%. There is a significant risk of developing CHD with extended criteria (5.05), as well as “definite” (5.28) and “possible” (3.13) forms in the male population at 25–64 years of age. In the 55 to 64 age group, there is a significant risk of developing CHD according to the extended criteria (5.57) and the “definite” form of CHD (10.21). Conclusion. Thus, the findings suggest the importance of further study of sleep disorders in working age men in Siberian populations, its relationships with conventional and non-conventional risk factors of CHD, as well as the feasibility of preventive measures aimed at reducing the influence of psycho-emotional stress factors among the Russian population.
The influence of the model and method choice on the DFT predicted 13C NMR chemical shifts of zeolite surface methoxide species has been systematically analyzed. Twelve 13C NMR chemical shift calculation protocols on full periodic and hybrid periodic-cluster DFT calculations with varied structural relaxation procedures are examined.

The primary assessment of the accuracy of the computational protocols has been carried out for the Si-O(CH3)-Al surface methoxide species in ZSM-5 zeolite with well-defined experimental NMR parameters (chemical shift, δ(13C) value) as a reference. Different configurations of these surface intermediates and their location inside the ZSM-5 pores are considered explicitly. The accuracy of the predicted 13C NMR chemical shifts for the computational assignment of spectral characteristics of zeolite intermediates has been further analyzed by considering the potential intermediate species formed upon methane activation by Cu/ZSM-5 zeolite.

The predicted δ value deviates by up to ±0.8 ppm from the experimental value of 59 ppm due to the varied confinement of the methoxide species at different zeolite sites (model accuracy). The choice of the exchange-correlation functional (method accuracy) introduces ±1.5 ppm uncertainty in the computed chemical shifts. The presence of Cu species in the vicinity of surface methoxide increases the prediction uncertainty to ±2.5 ppm. The full geometry relaxation of the local environment of an active site at an appropriate level of theory is critical to ensure a good agreement between the experimental and computed NMR data. Chemical shifts (δ) calculated via full geometry relaxation of a cluster model of a relevant portion of the zeolite lattice site are in the best agreement with the experimental values. Our analysis indicates that the full geometry optimization of a cluster model at the PBE0-D3/6-311G(d,p) level of theory followed by GIAO/PBE0-D3/aug-cc-pVDZ calculations is the most suitable approach for the calculation of 13C chemical shifts of zeolite surface intermediates.
Non-enzymatic protein glycation is a source of metabolic stress that contributes to cytotoxicity and tissue damage. Hyperglycemia has been linked to elevation of advanced glycation endproducts, which mediate much of the vascular pathology leading to diabetic complications. Enhanced glycation of immunoglobulins and their accelerated vascular clearance is proposed as a natural mechanism to intercept alternative advanced glycation endproducts, thereby mitigating microvascular disease.

We reported that antibodies against the glycoprotein KLH have elevated reactivity for glycopeptides from diabetic serum. These reactions are mediated by covalent binding between antibody light chains and carbonyl groups of glycated peptides. Diabetic animals that were immunized to induce reactive antibodies had attenuated diabetic nephropathy, which correlated with reduced levels of circulating and kidney-bound glycation products. Molecular analysis of antibody glycation revealed the preferential modification of light chains bearing germline-encoded lambda V regions. We previously noted that antibody fragments carrying V regions in the germline configuration are selected from a human Fv library by covalent binding to a reactive organophosphorus ester. These Fv fragments were specifically modified at light chain V region residues, which map to the combining site at the interface between light and heavy chains.

These findings suggest that covalent binding is an innate property of antibodies, which may be encoded in the genome for specific physiological purposes. This hypothesis is discussed in context with current knowledge of the natural antibodies that recognize altered self molecules and the catalytic autoantibodies found in autoimmune disease.
Aim . A study of the association of the methylation of the promoter of the ABCA1 gene with sudden cardiac death (SCD). Materials and methods . The study design is based on the case-control principle. The SCD group included 150 men (mean age (46.7 ± 9.2) years) who died of sudden cardiac death according to forensic medical examination data (the main pathological diagnoses are acute circulatory failure, acute coronary insufficiency). The control group included 150 men (mean age (42.6 ± 1.2) years) who died suddenly, but not due to cardiovascular pathology. DNA was isolated by phenol-chloroform extraction from myocardial tissue. The methylation status of the ABCA1 gene promoter was assessed by methyl-specific polymerase chain reaction. The results obtained were statistically processed in SPSS 16.0 using Pearson's test and Fisher's test with Yates' correction for continuity. P < 0.05 was used as a level of significance. Results . Comparing the groups revealed statistically significant differences in the methylation status of the gene promoter ( p = 0.015). In the SCD group, the proportion of individuals whose ABCA1 gene promoter is methylated is statistically significantly higher compared to the control group ( p = 0.020; OR = 5.86; 95% CI (1.28–26.89)). Conclusion. Methylation of the promoter of the ABCA1 gene is associated with sudden cardiac death.
The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
The closest analogues of the saber are stored in the Moscow Kremlin Armory, the State Hermitage Museum, the Metropolitan Museum of Art, etc. A common historiographical attribution of the saber as belonging to Erali Khan (1729) has been proved wrong.

We analyzed the construction and decoration of the saber and the scabbard and concluded that they were made by Ottoman masters in the first half of the 17th century. According to the inscription on the blade, we refer the weapon to the type of insignia, which were given to Kazakh rulers who became Russian citizens and were approved as khans.

The saber is of a high scientific value as it is the only surviving and almost undamaged symbol of Kazakh khans’ power. It is a unique relic of Russian-Kazakh relations in the 18th century.
Existing Monte-Carlo generators with radiative corrections to the e + e - →π + π - process are usually developed under the assumption that pions can be treated as pointlike particles. We study the e + e - →π + π - γ process with final-state radiation and test this assumption using simulated events from the MCGPJ generator based on the scalar QED hypothesis. In order to increase a fraction of events with FSR, the analysis was performed in the energy region to the left from the ρ -meson peak (660÷785 MeV) that is based on the integrated luminosity of about 8.4 pb -1 . The experimental data for the photon energy spectrum agree with the simulation results at 1% level.
Universe history in R2-gravity is studied from "beginning" up to the present epoch. It is assumed that initially the curvature scalar R was sufficiently large to induce the proper duration of inflation. Gravitational particle production by the oscillating R(t) led to a graceful exit from inflation, but the cosmological evolution in the early universe was drastically different from the standard one till the universe age reached the value of the order of the inverse decay rate of the oscillating curvature R(t). This deviation from the standard cosmology might have a noticeable impact on the formation of primordial black holes and baryogenesis. At later time, after exponential decay of the curvature oscillations, cosmology may return to normality.
The conversion decays φ → ηe + e -, φ → π 0 e + e -and η → γe + e -were studied by the SND detector using φ-meson production in e + e --annihilation at VEPP-2M collider.The e + e --pair mass spectra and transition form factors for φ → ηe + e -and η → γe + e -were also studied.
The cross section of the process e + e − → K S K L π 0 has been studied with the CMD-3 detector at the VEPP-2000 electron-positron collider in the center-of-mass energy range from 1.1 to 2 GeV. Preliminary results on the total cross section of the process are presented.
A new algorithm for the determination of the initial flavour of B0s mesons is presented. The algorithm is based on two neural networks and exploits the b hadron production mechanism at a hadron collider.

The first network is trained to select charged kaons produced in association with the B0s meson. The second network combines the kaon charges to assign the B0s flavour and estimates the probability of a wrong assignment. The algorithm is calibrated using data corresponding to an integrated luminosity of 3 fb−1 collected by the LHCb experiment in proton-proton collisions at 7 and 8 TeV centre-of-mass energies. The calibration is performed in two ways: by resolving the B0s–0s flavour oscillations in B0s → D−sπ+ decays, and by analysing flavour-specific B*s2(5840)0 → B+K− decays.

The tagging power measured in B0s → D−sπ+ decays is found to be (1.80 ± 0.19 (stat) ± 0.18 (syst))%, which is an improvement of about 50% compared to a similar algorithm previously used in the LHCb experiment.
A complete Hamiltonian formalism is suggested for inertial waves in rotating incompressible fluids. Resonance three-wave interaction processes – decay instability and confluence of two waves – are shown to play a key role in the weakly nonlinear dynamics and statistics of inertial waves in the rapid rotation case.

Future applications of the Hamiltonian approach to inertial wave theory are investigated and discussed.
Diffusion of aqueous solutions of K4[Re4Te4(CN)12] and CuCl2 in the opposite direction through silica gel gives rise to the new polymer-like compound 1.

This complex has a layered structure built from the interconnected cubane-like cluster cations [Cu4(μ3-OH)4]4+ and the cluster anions [Re4Te4(CN)12]4−.
Momentum distributions of strontium atoms are characterized by means of bimodal functional dependences, which properties depend on the laser field parameters. It is shown that ultracold fraction of atoms (T ≤ hγ/kB) can reach 60 %. The calculations are based on the quantum treatment of the problem with taking into account the recoil effect in full. The results can be used for ultradeep laser cooling of strontium atoms.
The ion chemistry model proposed earlier by Belhi et al. (2018) for lean methane flames

Spatial distributions of positively charged species naturally occurring in the stoichiometric and fuel-rich premixed H2/CO/O2/Ar flames are measured with molecular beam mass spectrometry

The hydronium (H3O+) ion and its clusters are found to be most abundant cations in the flames. The model was found to adequately predict the observed tendencies in the flames, once the exact mixture composition, including hydrocarbon impurities (∼5 ppm), is considered
There are many psychiatric medications targeting the activity of SLC transporters. Therefore, further research is needed to elucidate the expression profiles of the Slc* genes, which may serve as markers of altered brain metabolic processes and neurotransmitter activities in psychoneurological disorders.

We studied differentially expressed Slc genes using the transcriptomic profiles in the ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC) of male mice with psychosis-like behavior induced by repeated aggression experience in daily agonistic interactions which are accompanied by wins.

Most of differentially expressed Slc genes in the VTA and NAcc (12 of 17 and 25 of 26, respectively) were downregulated, which was not the case in the PFC (6 and 5, up- and down, respectively). Also, the majority of these genes were shown to have brain region-specific expression profiles. In the VTA and NAcc altered expression was observed for the genes encoding the transporters of neurotransmitters as well as inorganic and organic ions, amino acids, metals, glucose, etc . This means alteration in transport functions for many substrates, which results in complete disruption of all cellular and neurotransmitter processes. The neurotransmitter systems, especially, the dopaminergic one, in male mice with positive fighting experience in daily agonistic interactions undergo changes leading to profound genomic modifications which include downregulated expression of the majority of the Slc* genes at least in the VTA and NAcc, which is attributable to chronic stimulation of the reward systems.
We report the proof-of-concept of an operational laser active medium with a depressed cladding waveguide manufactured in the volume of a Cr 2+ :ZnS single-crystalline sample and antireflection microstructures fabricated on its facets exclusively by femtosecond laser processing techniques. This allowed us to achieve transmittance in a broad range from 2 to 8 µm, approaching a maximum of over 90% near 2.5 µm, and lasing at 2275 nm at the average output power of 20 mW for the absorbed pump power of 500 mW with the slope efficiency of 5.5 %. This demonstration opens up a route towards the industrial fabrication of compact integrable laser sources and sensors based on II-VI materials.
[HIr(IV)W6O24](7-), representing the first Ir-containing Anderson-Evans-type polyanion and the first structurally characterized Ir(IV)-based polyoxometalate, has been isolated as its hydrated sodium salt and characterized by single-crystal X-ray diffraction, mass spectrometry, and IR, UV-Vis and EPR spectroscopy. Cyclic voltammetry indicates that the Ir(IV) ions in [HIrW6O24](7-) can undergo reversible one-electron reduction and oxidation, resulting in Ir(III) and Ir(V) derivatives.
Camphor based heterocyclic systems containing 1,3-thiazolidin-4-one and thiazole rings showed promising antiviral activity towards Orthopoxviruses.