Hengzongshu/ArticleAgent huggingface dataset:
This system is used as a test module for a section of the GOL-3 magnetic trap. The study was carried out for the beam with a spread in initial electron pitch angles and a non-uniform radial current distribution.

The results of experiments and numerical simulation of compression of an intense electron beam in increasing field of magnetic mirror and its transmission through a linear magnetic system are presented. An analytical estimate of the vacuum beam-current limit was obtained taking into account the initial pitch angles of electrons and the beam compression in the magnetic field.

The simulation results are compared with the results of experiments; in both cases similar phenomena of beam reflection and diode breakdown are observed.
A series of new heterometallic compounds have been obtained by the co-crystallization of Cu(II) methoxy-substituted β-diketonates and Pb(II) hexafluoroacetylacetonate (hfac) from organic solvents. Their crystal structures were established by X-ray analysis. It is shown that the formation of heterometallic compounds proceeds with geometrical isomerization of the initial copper complexes, which can be controlled by varying terminal substituents in the ligand. Due to the ability of copper complexes to isomerize, the structure of the resulting heterocomplexes can be flexibly and purposefully changed from polymeric to discrete molecular forms. The study of the thermal properties shows that all the reported compounds are volatile and can be re-sublimed in a vacuum, with their composition and structure being retained.
Theory predicted that a multiple-mirror magnetic field should not significantly decelerate and weaken collisional plasma.

New experimental results on magnetic compression and transport of low-temperature arc plasma are presented. In the experiments, the transport efficiency of the plasma stream in a multiple-mirror configuration was compared with the same in a uniform solenoidal field. The magnetic compression ratio of the plasma stream varied from 5 to 60 at the initial diameter of 5 cm. In the presented work, we simulated the baseline scenario of GOL-NB filling by cold start plasma.

As the result, the plasma with (1 – 4)×1020 m-3 density at the axis was obtained at ∼3 m distance from the plasma source. The experiment confirmed this prediction.
In this decay channel, the CP-violating weak phase arises due to CP violation in the interference between B(s)(0)-B(s)(0) mixing and the b → sss gluonic penguin decay amplitude.

Using a sample of pp collision data corresponding to an integrated luminosity of 1.0 fb(-1) and collected at a center-of-mass energy of 7 TeV with the LHCb detector, 880 B(s)(0) → ϕϕ signal decays are obtained.

The CP-violating phase is measured to be in the interval [-2.46,-0.76] rad at a 68% confidence level. The p value of the standard model prediction is 16%.
The dynamics of hydrocarbon generation by the Jurassic and Cretaceous source rocks in the northeastern part of the Bolshaya Kheta megasyneclise was reconstructed by historical and geological modelling. The amounts of liquid and gaseous hydrocarbons generated by these sources rocks were estimated for each time period and catagenetic substage.
The paper reports on some results of the experimental study of flow and pressure pulsations in a laboratory model of the draft tube (DT) of Francis-99 hydro-turbine over a broad range of operating regimes. Velocity distributions at the model inlet varied within 866 modes of the turbine load conditions, including those with maximum coherent pressure pulsations on the model walls.

The contact and non-contact methods were used to measure pressure pulsations on the model walls using acoustic sensors and to measure the averaged velocity distribution with a laser Doppler anemometer "LAD-06i".

Analysis of the results have showed that in the model cone there are flow modes with forming of precessing vortex cores, accompanied by a sharp increase in the amplitude of coherent pressure pulsations on the wall and the velocity field rearrangement. It is shown that the vortex core starts forming with an increase in the integral parameter of swirl up to S>0.5. A novelty of the work is the combination of the rapid prototyping (3-d printing) of the inflow swirl generators and computerized measurement techniques that makes it possible to acquire rapidly a large amount of experimental data for a variety of designs and operating conditions. The results can provide insight into the effect of various design and operating parameters on the flow physics, as well as serve for verification of the numerical simulations.
The article presents the one-dimensional basin modeling performed in four wells to reconstruct the thermal history of deposits and reconstruct the effective values of the heat flow density.
Показано, что непрерывная 2π-периодическая функция однозначно восстановливается (на всей прямой) по известным последовательностям своих сумм Фейера в заданном конечном наборе точек тогда и только тогда, когда найдутся две точки из этого набора, расстояние между которыми несоизмеримо с π. И что полные наборы интегралов Фейера в любых двух различных точках всегда однозначно восстанавливают непрерывную абсолютно интегрируемую по Лебегу на всей прямой функцию.При этом ни по известной последовательности сумм Фейера в одной точке, ни по полному набору интегралов Фейера в одной точке ни одна из рассматриваемых непрерывных функций никогда не восстанавливается однозначно.
One of the major effects of domestication is change of animal coat colour to up to complete white colour of the whole body. It is possible that white colour of livestock animals had aesthetic significance for humans as well. The first step towards detection of genes and mutations controlling white colouring in animals is the genome-wide association studies. These studies, however, have not been done for the cattle breeds native to the Russian Federation. The aim of this study was therefore to identify genomic intervals and candidate genes that could be responsible for white face colouring in eight Russian cattle breeds. The data on genome-wide genotyping of 131,709 high-quality single nucleotide polymorphisms (SNPs) on 148 animas have been used in the program ­EMMAX. Association analysis has been performed using two related phenotypes: a) the white face with the rest of the body of any colour and b) white face with the rest of the body of different (non-white) colour. In the first case, the only statistically significant marker found was the SNP BovineHD0500019319 located on cattle chromosome (BTA) 5. The same SNP was the most significant within the cluster of three SNPs on BTA5: 68,803,879–69,365,854 associated also with the second phenotype. Five genes were found within this interval in the cattle genome, out of which the most likely functional candidate was SLC41A2, with the SNP BovineHD0500019319 found within its intronic sequence. SLC41A2 encodes a magnesium transporter protein. However, the function of this gene is not well established. Other members of this gene family are the key genes controlling differences in human skin and animal coat colour. Additional significant association signals with the second phenotype have been detected in BTA 1–4, 6–15, 18, 19, 24, 27, and 29. Overall, 37 genomic intervals have been detected associated with white face colouring in eight Russian native cattle breeds.
Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3.

Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4).

The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.
Researchers have assembled thousands of eukaryotic genomes using Illumina reads, but traditional mate-pair libraries cannot span all repetitive elements, resulting in highly fragmented assemblies. However, both chromosome conformation capture techniques, such as Hi-C and Dovetail Genomics Chicago libraries and long-read sequencing, such as Pacific Biosciences and Oxford Nanopore, help span and resolve repetitive regions and therefore improve genome assemblies. One important livestock species of arid regions that does not have a high-quality contiguous reference genome is the dromedary (Camelus dromedarius). Draft genomes exist but are highly fragmented, and a high-quality reference genome is needed to understand adaptation to desert environments and artificial selection during domestication. Dromedaries are among the last livestock species to have been domesticated, and together with wild and domestic Bactrian camels, they are the only representatives of the Camelini tribe, which highlights their evolutionary significance. Here we describe our efforts to improve the North African dromedary genome. We used Chicago and Hi-C sequencing libraries from Dovetail Genomics to resolve the order of previously assembled contigs, producing almost chromosome-level scaffolds. Remaining gaps were filled with Pacific Biosciences long reads, and then scaffolds were comparatively mapped to chromosomes. Long reads added 99.32 Mbp to the total length of the new assembly. Dovetail Chicago and Hi-C libraries increased the longest scaffold over 12-fold, from 9.71 Mbp to 124.99 Mbp and the scaffold N50 over 50-fold, from 1.48 Mbp to 75.02 Mbp. We demonstrate that Illumina de novo assemblies can be substantially upgraded by combining chromosome conformation capture and long-read sequencing.
We report on the thermalization of light carrying orbital angular momentum in multimode optical fibers, induced by nonlinear intermodal interactions. A generalized Rayleigh-Jeans distribution of asymptotic mode composition is obtained, based on the conservation of the angular momentum. We confirm our predictions by numerical simulations and experiments based on holographic mode decomposition of multimode beams. Our work establishes new constraints for the achievement of spatial beam self-cleaning, giving previously unforeseen insights into the underlying physical mechanisms.
The paper presents the analysis of the results of the Chinese higher education system reforming in the late 20th and early 21st century, shows the dynamics of the number of higher education institutions, the number of students and graduates. The structure of graduates in educational fields from 1995 to 2016 has been analyzed. The paper also presents the dynamics of funding of the China’s universities according to official statistics of China.

The national educational reforms led to a rapid growth of the number of the universities and the number of students. Higher education has turned from the elite phenomenon to a mass one. Gross enrolment ratio in tertiary education had been increased in 9,5 times (from 1995 to 2016) and reached 42,7% in 2016. Now the Chinese government provides an extensive support to the students studying at foreign universities. It is worth mentioning that the percentage of students who had returned to China after studying abroad has been increased in three times from 28% in 1995 to 79% in 2016.

The structure of graduates (according to educational fields) correlates with the needs of the growing Chinese economy: 34% of graduates have engineering professions. The largest rise of the number of graduates has been observed in economics and managerial specialties, as well as in pedagogy. The main contemporary result of the recent reforms is an international recognition of Chinese universities and a presence of the best of them in the top 100 of word university rankings.
A convenient synthetic method to diterpenoid dialkyne 18-propargyloxy-16-[(prop-2-yn-1-yloxi)methyl]labda-8( 17),13,15-triene in the common yield of 34 % from the natural plant diterpenoid lambertianic acid was developed.

1,2,3-Triazolyl containing macroheterocyclic compounds with an integrated diterpenoid fragment have been prepared by CuAAC reaction of the labdanoid dialkyne with organic diazides.
The photocatalytic activity of TiO2 depends on numerous factors, such as the chemical potential of electrons, charge transport properties, band-gap energy, and concentration of surface-active sites. A lot of research has been dedicated to determining the properties that have the most significant influence on the photocatalytic activity of semiconductors. Here, we demonstrated that the activity of TiO2 in the gas-phase reduction of CO2 is governed mainly by the desorption rate of the reaction intermediates and final products. This indicates that the specific surface area of TiO2 and binding strength of reaction intermediates and products are the main factors affecting the photocatalytic activity of TiO2 in the investigated process. Additionally, it was shown that rutile exhibits higher photocatalytic activity than anatase/rutile mixtures mainly due to its high efficiency in the visible portion of the electromagnetic spectrum.
Reliable recognition of the promoters in eukaryotic genomes remains an open issue. This is largely owing to the poor understanding of the features of the structural-functional organization of the eukaryotic promoters essential for their function and recognition.

However, it was demonstrated that detection of ensembles of regulatory signals characteristic of specific promoter groups increases the accuracy of promoter recognition and prediction of specific expression features of the queried genes. The ARGO_Motifs package was developed for the detection of sets of region-specific degenerate oligonucleotide motifs in the regulatory regions of the eukaryotic genes. The ARGO_Viewer package was developed for the recognition of tissue-specific gene promoters based on the presence and distribution of oligonucleotide motifs obtained by the ARGO_Motifs program.

Analysis and recognition of tissue-specific promoters in five gene samples demonstrated high quality of promoter recognition. The public version of the ARGO system is available at http://wwwmgs2.bionet.nsc.ru/argo/ and http://emj-pc.ics.uci.edu/argo/.
Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219) and ABCC8 (rs757110) was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia). Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, p
During production of the original article [1], there was a technical error that resulted in author corrections not being rendered in the PDF version of the article.
Ribosomal RNA (rRNA) maturation is a complex process that involves chemical modifications of the bases or sugar residues of specific nucleotides. One of the most abundant types of rRNA modifications, ribose 2-O-methylation, is guided by ribonucleoprotein complexes containing small nucleolar box C/D RNAs. Since the majority of 2-O-methylated nucleotides are located in the most conserved regions of rRNA that comprise functionally important centers of the ribosome, an alteration in a 2-O-methylation profile can affect ribosome assembly and function.

One of the key approaches for localization of 2-O-methylated nucleotides in long RNAs is a method based on the termination of reverse transcription. The current study presents an adaptation of this method for the use of fluorescently labeled primers and analysis of termination products by capillary gel electrophoresis on an automated genetic analyzer. The developed approach allowed us to analyze the influence of the synthetic analogues of box C/D RNAs on post-transcriptional modifications of human 28S rRNA in MCF-7 cells.

It has been established that the transfection of MCF-7 cells with a box C/D RNA analogue leads to an enhanced modification level of certain native sites of 2-O-methylation in the target rRNA. The observed effect of synthetic RNAs on the 2-O-methylation of rRNA in human cells demonstrates a path towards targeted regulation of rRNA post-transcriptional maturation. The described approach can be applied in the development of novel diagnostic methods for detecting diseases in humans.
We experimentally demonstrate spatial beam self-cleaning in an Yb-doped graded-index multimode fiber taper, both in passive and active configurations.

The input laser beam at 1064 nm was injected for propagation from the small to the large core side of the taper, with laser diode pumping in a counterdirectional configuration. The Kerr effect permits to obtain high-beam quality amplification with no accompanying frequency conversions.

As a result, our nonlinear taper amplifier may provide an important building block for multimode fiber lasers and amplifiers.
The human XPC-RAD23B complex and its yeast ortholog, Rad4-Rad23, are the primary initiators of global genome nucleotide excision repair. The interaction of these proteins with damaged DNA was analyzed using model DNA duplexes containing a single fluorescein-substituted dUMP analog as a lesion. An electrophoretic mobility shift assay revealed similarity between human and yeast proteins in DNA binding. Quantitative analyses of XPC/Rad4 binding to the model DNA structures were performed by fluorescent depolarization measurements. XPC-RAD23B and Rad4-Rad23 proteins demonstrate approximately equal binding affinity to the damaged DNA duplex (K(D) ∼ (0.5 ± 0.1) and (0.6 ± 0.3) nM, respectively). Using photoreactive DNA containing 5-iodo-dUMP in defined positions, XPC/Rad4 location on damaged DNA was shown. Under conditions of equimolar binding to DNA both proteins exhibited the highest level of cross-links to 5I-dUMP located exactly opposite the damaged nucleotide. The positioning of the XPC and Rad4 proteins on damaged DNA by photocross-linking footprinting is consistent with x-ray analysis of the Rad4-DNA crystal complex. The identity of the XPC and Rad4 location illustrates the common principles of structure organization of DNA damage-scanning proteins from different Eukarya organisms.
Using inclusive decays of , a precise determination of the number of events collected with the BESIII detector was performed. For the two data sets taken in 2009 and 2012, the numbers of events were recalculated to be and , respectively; these numbers are in good agreement with the previous measurements. For the sample taken in 2017–2019, the number of events was determined to be . The total number of events collected with the BESIII detector was determined to be , where the uncertainty is dominated by systematic effects, and the statistical uncertainty is negligible.
The artifacts, the burial rite, and the man’s Central Asian Mongoloid physical type unambiguously indicate a foreigner.

We analyzed the uniparental markers, such as mitochondrial DNA (HVRI sequence and informative positions in the coding part of mtDNA) and Y-chromosome (allelic profile of 17 STR-loci). The phylogeographic analysis, using data on ancient and modern populations of Eurasia.

The male’s mtDNA belongs to the East Eurasian haplogroup D4b1, and his Y-chromosome haplogroup Q (Q1a) is likewise East Eurasian. Thus, the individual’s eastern origin has been established, consistent with his physical type. The phylogeographic analysis revealed the presence of the East Eurasian D4b1-haplogroup both in the eastern and western Eurasian steppes. Importantly, it was present in Scythians of the northern Pontic area. Genetic data do not allow to locate the region whence the individual had migrated to Baraba. We propose a scenario that explains the disagreement between the paleogenetic and the craniometrical evidence. We discuss the possibilities and limitations of the paleogenetic approach to reconstructing the origins of ancient individuals.
We obtain asymptotic accuracy of the poissonisation in the innite occupancy scheme.Some of the results are obtained for integervalued random variables having a regularly varying distribution.
Docking and quantum-chemical methods have been used for screening of drug-like compounds from the own database of the Voronezh State University to find inhibitors the SARS-CoV-2 main protease, an important enzyme of the coronavirus responsible for the COVID-19 pandemic.

Using the SOL program more than 42000 3D molecular structures were docked into the active site of the main protease, and more than 1000 ligands with most negative values of the SOL score were selected for further processing. For all these top ligands, the protein-ligand binding enthalpy has been calculated using the PM7 semiempirical quantum-chemical method with the COSMO implicit solvent model. 20 ligands with the most negative SOL scores and the most negative binding enthalpies have been selected for further experimental testing. The latter has been made by measurements of the inhibitory activity against the main protease and suppression of SARS-CoV-2 replication in a cell culture. The inhibitory activity of the compounds was determined using a synthetic fluorescently labeled peptide substrate including the proteolysis site of the main protease. The antiviral activity was tested against SARS-CoV-2 virus in the Vero cell culture.

Eight compounds showed inhibitory activity against the main protease of SARS-CoV-2 in the submicromolar and micromolar ranges of the IC50 values. Three compounds suppressed coronavirus replication in the cell culture at the micromolar range of EC50 values and had low cytotoxicity. The found chemically diverse inhibitors can be used for optimization in order to obtain a leader compound, the basis of new direct-acting antiviral drugs against the SARS-CoV-2 coronavirus.
The mesoporous structures of tin oxide were obtained by a simple method of one-stage electrochemical anodizing of Sn foil in 1M NaOH in various anodizing modes. Anodizing in the pulse potentiostatic mode allowed determination of actual value of the voltage drop on the anode. For the first time the possibility of obtaining mesoporous oxide films on the surface of tin using galvanostatic mode of anodizing was demonstrated. It was found that the surface morphology of the obtained tin oxide layers is strongly dependent on the anodizing mode. Based on the data obtained, a two-stage mechanism was proposed for the growth of porous structures on the surface of tin in the galvanostatic mode including initial formation of the layer of SnO·xH 2 O which is subsequently oxidized to SnO2·xH 2 O mesoporouslayer.