Hengzongshu/ArticleAgent huggingface dataset:
The CMD-3 experiment at the VEPP-2000 collider in Novosibirsk carries out a comprehensive study of the exclusive cross-sections of $e^+e^- \to hadrons$ in the center-of-mass energy range from the threshold to $\sqrt{s}<2$ GeV. The CMD-3 results provide an important input for calculation of the hadronic contribution to the muon anomalous magnetic moment. Currently there are world-wide efforts to improve the accuracy of this calculation to match the expected precision of the new experiment at Fermilab to measure muon (g-2), now taking data. The best precision is still achieved by integrating the measured total cross-section of $e^+e^- \to hadrons$. The calculation is strongly dominated by low-energy data, in particular, by data at $\sqrt{s}<2$ GeV. Other interesting topics of the CMD-3 physics program include a study of hadron cross-sections at the nucleon-antinucleon threshold and a search for two-photon production of C-even resonances. The energy scan of the whole energy range was performed in 2011-2013 and, after detector and collider upgrade and increase in luminosity by factor 2-3, in 2017-2019. The total luminosity integral collected so far is 250 pb$^{-1}$. Here we present the current status of experiment and the survey of results of data analysis.
The cooling of microelectronic equipment is currently one of the most difficult problems of thermal physics. To achieve high heat fluxes and reduce the volume of liquid used, the technological solution looks especially promising, where heat is transferred from the fuel element to a thin, intensely evaporating film of liquid moving under the action of friction of a forced gas flow in a mini-or micro-channel. In recent works, the study of heat losses and determination of the true heat flux in experiments with an intensely evaporating liquid film moving under the action of a gas flow in a mini-channel was carried out. In this paper, the task is to verify the method for determining heat losses. Heat transfer in the convective flow regime is investigated. The experimental and calculated Nusselt numbers in convection experiments with complete channel flooding are in good agreement. In addition, the experimental and calculated Nusselt numbers for film flows are in good agreement. This indicates the correctness of the method for determining heat flux and heat losses in previous studies.
The article shows the use of a low-cost technology of engineering and seismological examination of the structural state of engineering structures in order to detect anomalous zones in them by the example of the survey of the Bugrinsky bridge in Novosibirsk.
The auxin and ethylene pathways cooperatively regulate a variety of developmental processes in plants. Growth responses to ethylene are largely dependent on auxin, the key regulator of plant morphogenesis. Auxin, in turn, is capable of inducing ethylene biosynthesis and signaling, making the interaction of these hormones reciprocal. Recent studies discovered a number of molecular events underlying auxin-ethylene crosstalk.

In this review, we summarize the results of fine-scale and large-scale experiments on the interactions between the auxin and ethylene pathways in Arabidopsis. We integrate knowledge on molecular crosstalk events, their tissue specificity, and associated phenotypic responses to decipher the crosstalk mechanisms at a systems level.

We also discuss the prospects of applying systems biology approaches to study the mechanisms of crosstalk between plant hormones.
The work is aimed at analyzing coordination mechanisms of corporate solutions and at studying a number of mechanisms, decision-making processes and information links with the use of hierarchical algorithms of block program ming. The work presents a routine task for high dimensional optimization adequate for the design of hierarchical systems of production companies and corporations, an objective function and a restriction system with composition-block structure. The special methods of block programming, where interaction between the center and the performers corresponds to the centralized and decentralized mechanisms of decision-making coordination in economic systems have been developed for this type of optimization problems. For the analysis of decision-making coordination in big systems, the unique classification of the mechanisms of decision-making coordination in hierarchical systems based on the level of information awareness of the center and the ways to increase this level has been applied. In the systems of the first type, the center is fully informed on the parameters of the objective function of the elements of the system (subsystems) and the set of admissible values of decision-making coordination or seeks to achieve such level of awareness. In this case the decision-making process is carried out in 2 stages. On the first stage, the center finds the optimum coordinating variables; on the second stage, the elements of the bottom level (blocks) sel ect ‘technological’ variables which implementation provides an optimal goal for the center. To achieve greater effectiveness and strict follow-up of the decisions made, the center can use such mechanisms of control as strong penalties. In the systems of another type, the center implements the principles of institutional and indicative management, i.e. it creates an institutional environment (structures, links, restrictions, etc.) for effective functioning of the elements (performers) and delegates it powers on decision-making to achieve the target parameters (indicators) optimal fr om the point of view of the center. It is shown that the convergence of the sequences of the specifying solutions of performers to an optimal decision-making for a system in general seems to be a necessary condition of institutional coordination methods.
The kinetics of copying of poly(A) · (dT) n , poly(A) · (U) n , poly(dA) · (dT) n and poly(A) · (dT) 9 ‐U by reverse transcriptase of human immunodeficiency virus‐1 (HIV‐1) has been studied and the binding affinity of the enzyme, for template or primer, determined. Short oligonucleotides and dTTP served as primers in the HIV‐1 reverse‐transcriptase‐dependent DNA synthesis. K m and V max were measured as functions of the primer chain length; the logarithm of the values of both K m and V max increased linearly up to 10. For longer primers ( n = 11 to n = 24) the increase of those values changes very little. The enhanced affinity of the primers, (dT) n or (U) n due to the formation of one complementary pair, A · dT, dA · dT, A · U was estimated as a factor of 2. A specific property of HIV‐1 reverse transcriptase compared with other DNA polymerases (procaryotes, eucaryotes, other retroviruses and archaebacteria) was its higher affinity to riboprimers as compared to deoxyriboprimers. Relative initial rates when copying poly(A) or poly(dA) templates using different primers and various conditions were compared; the optimal temperature for the reaction of polymerization with poly(A) or poly(dA) templates and (U) 10 , (dT) 10 or (dT) 9 ‐U primers was determined. The maximal activity of the enzyme in the case of poly(A) and decanucleotide primers was found at temperatures between 27–31°C. An increase in the primer length results in the stabilization of the template · primer duplex complexed to the enzyme, thus increasing to more than 40°C the optimal temperature of polymerization. The activation energy ( E a ) values of the polymerization reaction for different template · primer complexes were evaluated.
Full Bayesian inference for detecting copy number variants (CNV) from whole-genome sequencing (WGS) data is still largely infeasible due to computational demands. A recently introduced approach to perform Forward-Backward Gibbs sampling using dynamic Haar wavelet compression has alleviated issues of convergence and, to some extent, speed. Yet, the problem remains challenging in practice.

In this paper, we propose an improved algorithmic framework for this approach. We provide new space-efficient data structures to query sufficient statistics in logarithmic time, based on a linear-time, in-place transform of the data, which also improves on the compression ratio. We also propose a new approach to efficiently store and update marginal state counts obtained from the Gibbs sampler.

Using this approach, we discover several CNV candidates in two rat populations divergently selected for tame and aggressive behavior, consistent with earlier results concerning the domestication syndrome as well as experimental observations. Computationally, we observe a 29.5-fold decrease in memory, an average 5.8-fold speedup, as well as a 191-fold decrease in minor page faults. We also observe that metrics varied greatly in the old implementation, but not the new one. We conjecture that this is due to the better compression scheme. The fully Bayesian segmentation of the entire WGS data set required 3.5 min and 1.24 GB of memory, and can hence be performed on a commodity laptop.
Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons.

The cAMP (cyclic Adenosine MonoPhosphate)-mediated cascade of excitation and inhibition responses observed in MSN intracellular signal transduction is crucial for neuroscience research due to its involvement in the motor and behavioral functions.

In particular, all types of addictions are related to MSNs. Shedding the light on the mechanics of the above-mentioned cascade is of primary importance for this research domain.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme involved in energy metabolism. Recently, GAPDH has been suggested to have extraglycolytic functions in DNA repair, but the underlying mechanism for the GAPDH response to DNA damage remains unclear. Here, we demonstrate that the tyrosine kinase Src is activated under DNA damage stress and phosphorylates GAPDH at Tyr41. This phosphorylation of GAPDH is essential for its nuclear translocation and DNA repair function. Blocking the nuclear import of GAPDH by suppressing Src signaling or through a GAPDH Tyr41 mutation impairs its response to DNA damage. Nuclear GAPDH is recruited to DNA lesions and associates with DNA polymerase β (Pol β) to function in DNA repair. Nuclear GAPDH promotes Pol β polymerase activity and increases base excision repair (BER) efficiency. Furthermore, GAPDH knockdown dramatically decreases BER efficiency and sensitizes cells to DNA damaging agents. Importantly, the knockdown of GAPDH in colon cancer SW480 cells and xenograft models effectively enhances their sensitivity to the chemotherapeutic drug 5-FU. In summary, our findings provide mechanistic insight into the new function of GAPDH in DNA repair and suggest a potential therapeutic target in chemotherapy.
The article is a description of a research project that has been developed for several years now and is devoted to the study of Russian entrepreneurship history. One of the stages of the project was the creation of An Encyclopaedic Dictionary of the History of the Merchant Class and Trade in Siberia (Novosibirsk, Izdatel'stvo «GEO», 2012–2013). This is an unparalleled publication, the first dictionary of this kind in Russian historiography and it is worthy of attention because of the amount of information included and its structure (it contains videos, an academic bibliography, and the choice of authors is remarkable). The project is discussed by Vasiliy Pavlovich Zinoviev, professor of history (Tomsk State University), an eminent specialist in the economic history of Siberia; Evgeniya Vladislavovna Komleva, leading research fellow of the Department of the 2nd Half of the16th – Early 20th Century History of the Institute of History (Russian Academy of Sciences, Siberian Branch), executive editor of the Dictionary; Olga Dmitrievna Zhuravel’, dean of the faculty of Journalism, Novosibirsk State University. The article describes the problems that underlie the realization of this unique large-scale project, the informational potential of the Dictionary that makes it possible to substantiate not only the economic but also cultural paradigm, as well as entrepreneurship as a mode of living of Siberian merchants.
We present a qualitative but precise description of the linear beam-size effect predicted for the processes in which unstable but long-living particles collide with each other. We derive a physically pronounced equation for the event rate which proves that the linear beam-size effect corresponds to the scattering of one beam of particles on the decay products of the other. We compare this linear beam-size effect with the known logarithmic beam-size effect measured in the experiments on a single bremsstrahlung at Novosibirsk's VEPP-4 and DESY HERA.
Let Λ be the group generated by reflections in faces of a Coxeter tetrahedron in the hyperbolic space H 3 .A tetrahedral manifold is a hyperbolic manifold M = H 3 /Γ uniformized by a torsion free subgroup Γ of the group Λ.By a mirror symmetry we mean an orientation reversing isometry of the manifold acting by reflection.The aim of the paper to investigate mirror symmetries of the tetrahedral manifolds.
Meier‐Gorlin syndrome (MGS) is an autosomal recessive disorder characterized by microtia, primordial dwarfism, small ears, and skeletal abnormalities. Patients with MGS often carry mutations in the genes encoding the components of the pre‐replicative complex such as Origin Recognition Complex (ORC) subunits Orc1, Orc4, Orc6, and helicase loaders Cdt1 and Cdc6. Orc6 is an important component of ORC and has functions in both DNA replication and cytokinesis. Mutation in conserved C‐terminal motif of Orc6 associated with MGS impedes the interaction of Orc6 with core ORC. In order to study the effects of MGS mutation in an animal model system we introduced MGS mutation in Orc6 and established Drosophila model of MGS. Mutant flies die at third instar larval stage with abnormal chromosomes and DNA replication defects. The lethality can be rescued by elevated expression of mutant Orc6 protein. Rescued MGS flies are unable to fly and display multiple planar cell polarity defects. © 2015 Wiley Periodicals, Inc.
The glasses were found in the tuffisites of Orto-Yiarginskoe field (Anabar region, Arctic Siberia). The composition of the glasses is comparable with the composition of the glasses from the Popigai impact structure and the gneisses of the Archean basement of the Anabar folded system. The age of the studied glasses is comparable with the age of the glasses of the Popigai impact structure. Mineralogical studies were carried out using scanning electron microscopy (MIRA 3 LMU, Tescan Ltd) with the INCA Energy 450+ XMax 80 microanalysis system (Oxford Instruments Ltd). The age of the glasses is determined by the 40Ar-39Ar method in the Collective Use Center of the IGM SB RAS.
Some matrix detectors (CCD and CIS) have direct X-ray sensitivity and can operate as dispersionless spectrometers with a very large number of elements (106 and more). In the case of the impulse diffraction such detector can simultaneously record a significant number of independent events.

The mathematical processing of the received data with respect to the Bragg condition can theoretically lead to the coordinates of the events of one fixed energy and to form an analogue of powder diffraction patterns. In this case the registration can be performed on the "white" SR beam for a short time (up to 1 ns or less). The possibility of using of the 2000-element linear CCD ILX511 (Sony) as X-ray dispersionless spectrometer allowed to conduct simulation experiments to obtain diffraction patterns of graphite, boron nitride, boric acid and TNT-hexogen solid detonation products. SR beam from VEPP-3 storage ring was modulated by a mechanical chopper and statistics were provided by a multiple recording with on-line processing.

In the reading the position and energy of the absorbed X-ray photon may be restored for each event.
To examine the differences in clinical parameters in patients with coronary atherosclerosis based on fatty acid profile.

60 men with angiographically verified atherosclerosis of the coronary arteries underwent the analysis of fatty acids followed by coronary endarterectomy. Patients were divided into two groups after histological analysis of the intimamedia fragments. Men without unstable plaques in the coronary arteries were included in Group 1, whereas patients with unstable atherosclerotic plaques were included in Group 2. Blood serum levels of fatty acids were measured by highefficiency gas-liquid chromatography. The predicted probability value and the predicted group membership in men with coronary atherosclerosis were calculated using the logistic regression.

The following clinical patterns in men with unstable atherosclerotic plaques included increased prevalence of myocardial infarction with the event over 10 years ago, severe angina pectoris (III and IV functional class) and chronic heart failure, in comparison with CAD patients without unstable plaques. Fatty acid profile was associated with altered individual history of coronary atherosclerosis.
Understanding methane activation pathways on Zn-modified high-silica zeolites (ZSM-5, BEA) is of particular importance because of the possibility of methane involvement in coaromatization with higher alkanes on this type of zeolites. Herein, two samples of Zn-modified zeolite BEA containing exclusively either small zinc oxide clusters or isolated Zn2+ cations have been synthesized and thoroughly characterized by a range of spectroscopic methods (1H MAS NMR, DRIFTS, XPS, EXAFS, HRTEM) to show that only one of the Zn-species, either Zn2+ cations or ZnO small clusters, exists in the void of zeolite pores. The ability of zinc sites of different nature to promote the activation of methane C–H bond with the zeolite Brønsted acid sites (BAS) has been examined in the reactions of methane H/D hydrogen exchange with BAS and the alkylation of benzene with methane. It has been found that both ZnO and Zn2+ species promote the reaction of H/D exchange of methane with BAS. The rate of H/D exchange is higher by 2 and 3 orders of magnitude for the zeolite loaded with ZnO or Zn2+ species, respectively, compared to pure acid-form zeolite H-BEA. So, the promoting effect of Zn2+ cations is more profound than that of ZnO species for H/D exchange reaction. This implies that the synergistic effect of Zn-sites and BAS for C–H bond activation in methane is significantly higher for Zn2+ cations compared to small ZnO clusters. It has been revealed, however, that only Zn2+ cations promote the alkylation of benzene with methane, whereas ZnO species do not. The isolated Zn2+ cations provide the formation of zinc-methyl species, which are further transformed to zinc-methoxy species. The latter is the key intermediate for the performance of the alkylation reaction. Hence, while both zinc oxide clusters and Zn2+ cationic species are able to provide a synergistic effect for the activation of C–H bonds of methane displayed by the dramatic acceleration of H/D exchange reaction, only the Zn2+ cationic species perform methane activation toward the alkylation of benzene with methane. This implies that only the Zn2+ cations in Zn-modified zeolite can activate methane for the reaction of methane coaromatization with higher alkanes.
The paper discusses the pioneering results of comprehensive hydrogeochemical studies of natural waters of the Baydar valley (southwestern parts of the Crimean Peninsula), whose major aquifers are confined to the upper Jurassic sediments (karst limestone) representing the most important hydrogeological feature of the study area. Fresh and ultra-fresh waters of predominantly bicarbonate calcium composition with total mineralization in the range from 194 to 1137 mg/dm 3 are most widespread in the region. The analyzed waters (surface, ground and artesian) differ significantly in chemical composition and their basic characteristics have been arranged in the following patterns: mineralization of 254-832 mg/dm 3 and neutral pH (6.98-7.54) for artesian waters ; higher mineralization level (up to 1137 mg/dm 3 ) and wide variations of pH values (from 7.18 to 8.31) for ground waters ; mineralization from 194 to 288 mg/dm 3 and a slightly alkaline pH (between 8.02 and 8.04) for surface waters collected in the Chyornaya river basin and Chernorechensk reservoir. The studied waters display a unique spectrum of trace elements and REE distribution.
We present a measurement of multiple Coulomb scattering of 1 to 6 GeV/c electrons in thin (50–140 μm) silicon targets. The data were obtained with the EUDET telescope Aconite at DESY and are compared to parametrisations as used in the Geant4 software package.

In order to achieve a better description of the shape, a new scattering model based on a Student's t distribution is developed and compared to the data.

We find good agreement between data and simulation in the scattering distribution width but large deviations in the shape of the distribution.
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors.

To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four European discovery populations. In parallel, we measured IgG N-glycans using MALDI-TOF mass spectrometry (MS) in a replication cohort of 1,848 Europeans. Meta-analysis of genome-wide association study (GWAS) results identified 9 genome-wide significant loci (P<2.27×10−9) in the discovery analysis and two of the same loci (B4GALT1 and MGAT3) in the replication cohort. Four loci contained genes encoding glycosyltransferases (ST6GAL1, B4GALT1, FUT8, and MGAT3), while the remaining 5 contained genes that have not been previously implicated in protein glycosylation (IKZF1, IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1, and SMARCB1-DERL3). However, most of them have been strongly associated with autoimmune and inflammatory conditions (e.g., systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, Crohn's disease, diabetes type 1, multiple sclerosis, Graves' disease, celiac disease, nodular sclerosis) and/or haematological cancers (acute lymphoblastic leukaemia, Hodgkin lymphoma, and multiple myeloma). Follow-up functional experiments in haplodeficient Ikzf1 knock-out mice showed the same general pattern of changes in IgG glycosylation as identified in the meta-analysis. As IKZF1 was associated with multiple IgG N-glycan traits, we explored biomarker potential of affected N-glycans in 101 cases with SLE and 183 matched controls and demonstrated substantial discriminative power in a ROC-curve analysis (area under the curve = 0.842).

Our study shows that it is possible to identify new loci that control glycosylation of a single plasma protein using GWAS. The results may also provide an explanation for the reported pleiotropy and antagonistic effects of loci involved in autoimmune diseases and haematological cancer.
At the early 1880s Altai appeared the place of sharp clashes between old-dwellers and peasant migrants.The most famous of these conflicts occurred in the early 1880s in the village of Novo-Tyryshkino.In the document published it is described by the chairman of the Tomsk province council N.N.Petukhov.He was one of the most active and most experienced officials of the Tomsk province, who personally met with peasants at Novo-Tyryshkino trying to find a way to settle the conflict.

His description allows us to see behind a particular case some common problems that influenced the course and results of the Great Siberian migration.

First of all, it is the phenomenon known in demographic science as the chain migration.This makes it possible to compare the Great Siberian migration of the second half of the late Russian empire with other large migrations of different epochs.