Hengzongshu/ArticleAgent huggingface dataset:
This article presents the results of interdisciplinary studies of gold artifacts from the elite Xiongnu burials at Noin-Ula (Noyon Uul, Mongolia, early 1st millennium AD), excavated by the Russian-Mongolian expedition in 2006–2012. These include ornaments from coffins and clothes, made by Chinese artisans.

Using scanning electron microscopy, atomic absorption spectroscopy, and inductively coupled plasma mass spectrometry, 17 artifacts were analyzed. Results suggest that they were all made of native gold, similar to that from the known deposits of Mongolia in terms of elemental composition (for comparison, we used an electronic database relating to 3338 samples of Mongolian native gold). Results of statistical tests suggest that placer deposits were the most probable source of the gold.

The results do not contradict the idea that Chinese artisans used Mongolian gold. During the Han era, the Xiongnu could have been among their principal providers. The relationships between the two empires and peoples were always beneficial for the Xiongnu. Enjoying the numerous achievements of the Han civilization, they offered too little in return. One of the ways the Han dynasty could have benefited from their tumultuous neighbors was to receive native gold from them.
Effects of a subanesthetic dose of ketamine and acute stress on the major (p75, Trkb, Trkc) and novel (Sorcs1, Sorcs2, Sorcs3) neurotrophin receptors and Bdnf gene expression in rats were examined.

Adult male Wistar rats were treated with ketamine (15 mg/kg) or saline and half of each group was subjected to tail suspension test for 6 minutes, which was interpreted as an acute mild stressor. After an hour the total RNA was isolated from prefrontal cortex, midbrain and brainstem regions of each animal and mRNA expressions were analysed by real-time RT-PCR.

The results showed different significant interactions between factors which were strongly dependent on the structure of the brain. Both subanesthetic doses of ketamine and acute mild stress caused changes in neurotrophin receptors and Bdnf gene expression in examined brain areas associated with depression. The obtained results allow to surmise that BDNF, SORCS1, SORCS3 and p75 receptors are involved in the ketamine-induced neuroplasticity and antidepressant activity.
Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established.

Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site‐specific hydrolysis of four known SCZ specific microRNAs (miR‐137, miR‐9‐5p, miR‐219‐2‐3p, and miR‐219a‐5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops.

RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.
Licensing of the western regions of the Republic of Sakha (Yakutia) was considered as of 03.01.2021. 76 subsoil plots were allocated on this territory and 23 companies engaged in geological exploration, exploration and production of hydrocarbons were registered. The largest volume of exploration work was carried out by PJSC Surgutneftegas and Rosneft. In the period from 2009 to 2020, 15 oil and gas fields were discovered.
We have used ISR technique to measure the proton magnetic form factor in the energy region from 3.0 to 6.5 GeV and charged kaon form factor in the range from 2.6 to 7.5 GeV. The proton data clearly indicate that the difference between values of time- and space-like magnetic form factors decreases with increase of energy. The kaon form factor decreases with energy faster than 1/E2, approaching the asymptotic pQCD predictions.
Barley ( Hordeum vulgare L.) is the one of the most important cereal species used as food and feed crops, as well as for malting and alcohol production. At the end of the last century, traditional breeding techniques were complemented by the use of DNA markers. Molecular markers have also been used extensively for molecular genetic mapping and QTL analysis. In 2012, the barley genome sequencing was completed, which provided a broad range of new opportunities – from a more efficient search for candidate genes controlling economically important traits to genomic selection. The review summarizes the results of the studies performed after barley genome sequencing, which discovered new areas of barley genetics and breeding with high throughput screening and genotyping methods. During this period, intensive studies aimed at identification of barley genomic loci associated with economically important traits have been carried out; online databases and tools for working with barley genomic data and their deposition have appeared and are being replenished. In recent years, GWAS analysis has been used for large-scale phenotypegenotype association studies, which has been widely used in barley since 2010 due to the developed SNP-arrays, as well as genotyping methods based on direct NGS sequencing of selected fractions of the genome. To date, more than 80 papers have been published that describe the results of the GWAS analysis in barley. SNP identification associated with economically important traits and their transformation into CAPS or KASP markers convenient for screening selection material significantly expands the possibilities of marker-assisted selection of barley. In addition, the currently available information on potential target genes and the quality of the whole barley genome sequence provides a good base for applying genome editing technologies to create material for the creation of varieties with desired properties.
Вводится и изучается новая, обобщенная модель кооперативной игры с трансферабельной полезностью (ТП-игра), в которой кроме характеристической функции используются две дополнительные функции: отношений между игроками и вероятности образования коалиций, которые отражают основные черты взаимодействия людей в конкретных группах.

Изучаются различные свойства функции вероятности и доказано, какие из них являются достаточными для ее трансформации в вероятностную меру. Обобщенный вектор Шепли определяется для нового класса игр как математическое ожидание игрока от его маргинального вклада в коалиции.

Приведены необходимые и достаточные условия, чтобы обобщенный вектор Шепли полностью совпадал с классическим, введенным Шепли
Catalyst speciation during polymerization of 1-hexene in benzene or toluene solutions of the catalyst precursor SBIZr(μ-Me)2AlMe2+ B(C6F5)4− (SBI = rac-dimethylsilyl-bis(1-indenyl)) at 23 °C is studied by following the accompanying UV-vis-spectral changes.

These indicate that the onset of polymerization catalysis is associated with the concurrent formation of two distinct zirconocene species. One of these is proposed to consist of SBIZr-σ-polyhexenyl cations arising from SBIZr-Me+ (formed from SBIZr(μ-Me)2AlMe2+ by release of AlMe3) by repeated olefin insertions, while the other one is proposed to consist of SBIZr-η3-allyl cations of composition SBIZr-η3-(1-R-C3H4)+ (R = n-propyl), formed by σ-bond metathesis between SBIZr-Me+ and 1-hexene under release of methane. At later reaction stages, all zirconocene-σ–polymeryl cations appear to decay to yet another SBIZr-allyl species, i.e., to cations of the type SBIZr-η3-(x-R-(3-x)-pol-C3H3)+ (pol = i-polyhexenyl, x = 1 or 2). Renewed addition of excess 1-hexene is proposed to convert these sterically encumbered Zr-allyl cations back to catalytically active SBIZr-σ–polymeryl cations within a few seconds, presumably by initial 1-hexene insertion into the η1- isomer, followed by repeated additional insertions, while the initially formed, less crowded allyl cations, SBIZr-η3-(1-R-C3H4)+ appear to remain unchanged.

Implications of these results with regard to the kinetics of zirconocene-catalyzed olefin polymerization are discussed.
Оптимизация переупорядочивания модельных частицпри реализации метода частиц в ячейках на GPU А. А. Романенко 1 , А. В
Neuroimaging studies have revealed a multitude of brain regions associated with self- and other-referential processing, but the question how the distinction between self, close other, and distant other is processed in the brain still remains unanswered. The default mode network (DMN) is the primary network associated with the processing of self, whereas task-positive networks (TPN) are indispensable for the processing of external objects.

To test this hypothesis, we used functional magnetic resonance imaging (fMRI) functional connectivity data obtained in the course of a trait adjective judgment task while subjects evaluated themselves, the best friend, a neutral stranger, and an unpleasant person.

A positive association between the degree of self-relatedness and the degree of DMN dominance was revealed in cortical midline structures (CMS) and the left lateral prefrontal cortex. Relative to TPN, DMN showed greater connectivity in me than in friend, in friend than in stranger, and in stranger than in unpleasant conditions. These results show that the less the evaluated person is perceived as self-related, the more the balance of activity in the brain shifts from the DMN to the TPN.
This paper presents an automatic algorithm for the segmentation of areas affected by an acute stroke on the non-contrast computed tomography brain images. The proposed algorithm is designed for learning in a weakly supervised scenario when some images are labeled accurately, and some images are labeled inaccurately. Wrong labels appear as a result of inaccuracy made by a radiologist in the process of manual annotation of computed tomography images. We propose methods for solving the segmentation problem in the case of inaccurately labeled training data. We use the U-Net neural network architecture with several modifications. Experiments on real computed tomography scans show that the proposed methods increase the segmentation accuracy.
Familial hypercholesterolemia is a hereditary autosomal dominant disease characterized by a violation of cholesterol metabolism. This nosology was first described in the late 1930s by the Norwegian clinician Karl Moeller, he proposed the idea that hypercholesterolemia and tendon xanthomas are associated with cardiovascular diseases through the inheritance of a single gene. In 1964, two clinical phenotypes of familial hypercholesterolemia were discovered: heterozygous and homozygous, associated with an unfavorable prognosis.

To date, it is known that the long-running process of accumulation of low-density lipoproteins in the intima of blood vessels may not have clinical symptoms for many years due to the developed system of collaterals and the absence of hemodynamically significant stenosis.

However, without timely diagnosis and appropriate therapy, this condition inevitably leads to the development of a cardiovascular event. The article presents a clinical case demonstrating the development of myocardial infarction in a patient with a late diagnosis of this disease.
Dendritic molecules bearing metal complexes in their structure (metallodendrimers and metallodendrons) are considered prospective therapeutic entities. In particular, metallodendrons raise interest as antitumor agents for the treatment of poorly curable or drug-resistant tumors.

Herein, we have synthesized amphiphilic triazine-phosphorus dendrons bearing multiple copper (II) or gold (III) complexes on the periphery and a branched hydrophobic fragment at the focal point. Due to their amphiphilic nature, metallodendrons formed single micelles (mean diameter ~9 nm) or multi-micellar aggregates (mean diameter ~60 nm) in a water solution. We have tested the antitumor activity of amphiphilic metallodendrons towards glioblastoma, a malignant brain tumor with a notoriously high level of therapy resistance, as a model disease.

The metallodendrons exhibit higher cytotoxic activity towards glioblastoma stem cells (BTSC233, JHH520, NCH644, and SF188 cell lines) and U87 glioblastoma cells (IC50 was 3-6 µM for copper-containing dendron and 11-15 µM for gold-containing dendron) in comparison with temozolomide (IC50 >100 µM)-the clinical standard of care for glioblastoma. Our findings show the potential of metallodendron-based nanoformulations as antitumor entities.
Redox reactions of [(L 1,2 Mg) 2 ] and Sb 2 R 4 (R=Me, Et) yielded the first Mg‐substituted realgar‐type Sb 8 polystibides [(L 1,2 Mg) 4 (μ 4 ,η 2:2:2:2 ‐Sb 8 )] (L 1 =HC[C(Me)N(2,4,6‐Me 3 C 6 H 2 )] 2 , L 2 =HC[C(Me)N(2,6‐ i ‐Pr 2 C 6 H 3 )] 2 ). Compounds [(L 1,2 Mg) 2 ] serve both as reducing agents, initiating the cleavage of the Sb−C bonds, and as stabilizers for the resulting Sb 8 polyanion.

The polystibides were characterized by NMR and IR spectroscopies, elemental analysis, and X‐ray structure analysis.

In addition, results from quantum chemical calculations are presented.
Представлен прямой численный метод решения обратной коэффициентной задачи для эллиптического уравнения с кусочно-постоянными коэффициентами.Предполагается, что точки разрыва коэффициентов известны.Алгоритм основан на теории спектральных задач линейной алгебры и применении конечно-разностных методов решения эллиптических уравнений.В качестве дополнительной информации используются значения
The characteristics of explosive boiling of water, propanol-1, propanol-2, n-nonane were obtained using optical method for measuring the laser intensity reflected from the microheater surface. A multi-layered thin film heater was used in the experiments with size of 100x110 μm.

The experimental data show that high heat flux density provides the conditions for the phase explosion patterns. Four major stages of explosive boiling on microheater were selected and the dynamics of filling the heater surface with vapor phase, the lifetime of the main vapor bubble and the satellite bubble were determined.
A study of the association of the methylation of the promoter of the ABCA1 gene with sudden cardiac death (SCD).

The study design is based on the case-control principle. The SCD group included 150 men (mean age (46.7 ± 9.2) years) who died of sudden cardiac death according to forensic medical examination data (the main pathological diagnoses are acute circulatory failure, acute coronary insufficiency). The control group included 150 men (mean age (42.6 ± 1.2) years) who died suddenly, but not due to cardiovascular pathology. DNA was isolated by phenol-chloroform extraction from myocardial tissue. The methylation status of the ABCA1 gene promoter was assessed by methyl-specific polymerase chain reaction. The results obtained were statistically processed in SPSS 16.0 using Pearson's test and Fisher's test with Yates' correction for continuity. P < 0.05 was used as a level of significance.

Comparing the groups revealed statistically significant differences in the methylation status of the gene promoter ( p = 0.015). In the SCD group, the proportion of individuals whose ABCA1 gene promoter is methylated is statistically significantly higher compared to the control group ( p = 0.020; OR = 5.86; 95% CI (1.28–26.89)). Conclusion. Methylation of the promoter of the ABCA1 gene is associated with sudden cardiac death.
Plasma-arc (PA) sputtering method was applied for synthesis of Pt/CeO2 and Pd/CeO2 nanoparticles. PA represents a joint sputtering of a graphite electrode with various metals (Ce with Pt or Pd). This novel approach allows obtaining highly dispersed metals and ceria on the first stage of synthesis. The thermal treatment of an initial composite in air at 600°C-1000°C results in the burnt of a carbon shell and formation of CeO2 with a fluorite-type structure. XPS and TEM analysis showed that Pd and Pt species are stabilized in the ionic form due to strong interaction with ceria. Obtained nanoparticles have a high potential of application as catalysts for efficient low temperature CO oxidation.
The title compound, C(3)H(8)NO(2)S(+)·C(2)HO(4)(-), (I), crystallizes in the monoclinic C2 space group and is a new form (possibly a hydrate) of L-cysteinium semioxalate with a stoichiometric cation-anion ratio of 1:1. In contrast to the previously known orthorhombic form of L-cysteinium semioxalate, (I) has a layered structure resembling those of monoclinic L-cysteine, as well as of DL-cysteine and its oxalates. The conformations of the cysteinium cation and the oxalate anion in (I) differ substantially from those in the orthorhombic form. The structure of (I) has voids with a size sufficient to incorporate water molecules. The residual density, however, suggests that if water is in fact present in the voids, it is strongly disordered and its amount does not exceed 0.3 molecules per void. The difference in conformation of the cysteinium cations in (I) and in the orthorhombic form is similar to that in DL-cysteine under ambient conditions and in DL-cysteine under high pressure or at low temperature.
The TRPM8 gene encodes the ion channel, which is a cold receptor in afferent neurons of the mammalian somatosensory system.

We studied the frequency of haplotype distribution from six SNPs in the TRPM8 gene in Eurasian human populations, including Russians, Kazakhs and Chukchi. Four of the six SNPs are located in exon 7 (rs13004520, rs28901637, rs11562975, rs17868387), rs7593557 is in exon 11. These exons encode parts of the N-terminus, which is necessary for channel functioning in the plasma membrane of neurons. The rs11563071 is in exon 23 encoding part of the C-terminus. We analyzed sequences of five TRPM8 mRNA isoforms extracted by researchers from different tissues.

The primary difference in population distribution of haplotypes determines the SNP from exon 11 which leads to Ser419Asn substitution in protein. The most pronounced differences in the patterns of diversity and frequencies of haplotypes were observed between Chukchi and Russians. The frequency of major H1 haplotype encompassing the 419Ser gene variant differs in examined populations; 0.738 (Russians), 0.507 (Kazakhs) and 0.337 (Chukchi), p < 0.001. The TRPM8 gene variants encoding 419Asn and carrying the minor alleles of rs28901637 (P249P) and rs11562975 (L250L) in exon 7 are characteristic of Asian populations. The frequency of all 419Asn variants in Chukchi is comparable to that in Africans, however, the minor allele frequencies of rs28901637, rs11562975 in Africans is low. Apparently in the process of human colonization of Eurasia, minor alleles of these SNPs diverged depending on rs7593557 structure in exon 11. Sequence analysis demonstrates that they are transcribed from major H1 variant of the TRPM8 gene but contain different translation start codons, which are generated by alternative splicing from pro-mRNA.
Coupling of the pre-reforming and partial oxidation was considered for the conversion of liquefied petroleum gas to syngas for the feeding applications of solid oxide fuel cells. Compared with conventional two step steam reforming, it allows the amount of water required for the process, and therefore the energy needed for water evaporation, to be lowered; substitution of high-potential heat by lower ones; and substitution of expensive tubular steam reforming reactors by adiabatic ones. The supposed process is more productive due to the high reaction rate of partial oxidation. The obtained syngas contains only ca. 10 vol.% H2O and ca. 50 vol.% of H2 + CO, which is attractive for the feeding application of solid oxide fuel cells. Compared with direct partial oxidation of liquefied petroleum gas, the suggested scheme is more energy efficient and overcomes problems with coke formation and catalyst overheating. The proof-of-concept experiments were carried out. The granular Ni-Cr2O3-Al2O3 catalyst was shown to be effective for propane pre-reforming at 350–400 °C, H2O:C molar ratio of 1.0, and flow rate of 12,000 h−1. The composite Rh/Ce0.75Zr0.25O2-δ–ƞ-Al2O3/FeCrAl catalyst was shown to be active and stable under conditions of partial oxidation of methane-rich syngas after pre-reforming and provided a syngas (H2 + CO) productivity of 28 m3·Lcat−1·h−1 (standard temperature and pressure).
This work is dedicated to the search for the exact analytical dependences of microwave heating due to absorption of a plane electromagnetic wave by coal layer with asymmetric and non-uniform heat dissipation conditions I and III kind.

Some of simplifications have been made, such as one-dimensional problem, uniformity and isotropic coal material, and the constancy of the electrical properties of thermal coal during heating of microwave radiation. This has led to the fact that the Maxwell’s task is solved separately from the Fourier’s task, and a heat source generated in the carbon layer is subject to Bouguer law. For the system of equations of heat transfer has been found a new dependent variable, which is to simplify the search for a final solution.

All this has given the possibility of finding rigorous analytical solution of the problem of microwave heating of the coal layer in the presence of asymmetric and inhomogeneous boundary conditions I and III kind.
Dilated cardiomyopathy (DCM) is a complex, etiologically heterogeneous myocardial disease, which is one of the main causes of heart failure and heart transplantation. In 2016, experts from the European working group proposed a new definition of cardiomyopathy, which includes intermediate variants with a change in phenotype in carriers of mutations from subclinical form to the full manifestations of the disease. The classification of DCM was supplemented with intermediate phenotypes with the inclusion of a hypokinetic form with reduced contractile function without ventricular dilatation and variants with predominant dilation or arrhythmogenicity.

Pathological architectonics of DCM consists of many genetic determinants that interact with numerous environmental factors. Clinical manifestations depend not only on the malignancy and penetrance of the gene mutation, but also on a number of other causes — epigenomic factors, age, toxic effects, environmental aggressiveness, pregnancy, and the effects of other acquired diseases.

The article summarizes the current epidemiological data and ideas about specific molecular changes with an unfavorable prognosis. For clarity, we present clinical observations of familial DCM with mutations in the RBM20 and LMNA genes.
A shallow water model of film flow is used to describe the process of a drop spreading on a horizontal plane, taking into account the liquid viscosity, heat-mass transfer and surface tension forces. To simulate this flow numerically in polar coordinates an unconditionally stable implicit difference scheme has been developed, which (in the case of evaporation) can calculate the drop spreading over a dry surface without special allocation of the drop boundary. A region of dimensionless parameters is singled out under which the evaporating droplet, as a result of surface tension forces, transforms into a circular ring before complete evaporation.
The resonant substructure of B0s→¯D0K−π+ decays is studied using a data sample corresponding to an integrated luminosity of 3.0 fb−1 of pp collision data recorded by the LHCb detector.

An excess at m(¯D0K−)≈2.86 GeV/c2 is found to be an admixture of spin-1 and spin-3 resonances. Therefore, the D∗sJ(2860)− state previously observed in inclusive e+e−→¯D0K−X and pp→¯D0K−X processes consists of at least two particles.

This is the first observation of a heavy flavored spin-3 resonance, and the first time that any spin-3 particle has been seen to be produced in B decays. The masses and widths of the new states and of the D∗s2(2573)− meson are measured, giving the most precise determinations to date.