Hengzongshu/ArticleAgent huggingface dataset:
the earlier LES and experiments of the flow over a stagnant cylinder at the same Re number described in Palkin et al. (Flow Turbul. Combust., vol. 97 (4), 2016, pp. 1017–1046)

the three-dimensional unsteady computations were performed using a wall-integrated (WIN) second-moment (Reynolds-stress) Reynolds-averaged Navier–Stokes (RANS) turbulence closure, verified and validated by a dynamic large-eddy simulations (LES) for selected cases

The drag reduction was detected at frequencies equal to and larger than f=2.5. The maximum reduction of the drag coefficient is 88% for the highest tested frequency f=5 and amplitude Ω=2. Such a dramatic reduction in the drag coefficient is the consequence of restructuring of the vortex-shedding topology and a markedly different pressure field featured by a shrinking of the low pressure region behind the cylinder, all dictated by the rotary oscillation.
This differs from the previously reported substitution in K[C 6 F 5 BF 3 ] by O- and N-nucleophiles that did not produce K[2-NuC 6 F 4 BF 3 ].

Borates M[C 6 F 5 BF 3 ] (M = K, Li, Bu 4 N) react with organolithium compounds, RLi (R = Me, Bu, Ph), in 1,2-dimethoxyethane or diglyme to give M[4-RC 6 F 4 BF 3 ] and M[2-RC 6 F 4 BF 3 ].

When R is Me or Bu, the nucleophilic substitution of the fluorine atom at the para position to boron is the predominant route. When R = Ph, the ratio M[4-RC 6 F 4 BF 3 ]/M[2-RC 6 F 4 BF 3 ] is ca. 1:1. Substitution of the fluorine atom at the ortho position to boron is solely caused by the coordination of RLi via the lithium atom with the fluorine atoms of the BF 3 group.
a graphene decorated SiC nanomaterial (graphene@SiC) fabricated via a facile adiabatic process was physicochemically characterised, then applied as a supercapacitor material and as an anode within a Li-ion battery (LIB)

The reported graphene@SiC nanomaterial demonstrated excellent supercapacitative behaviour with a relatively high power density and specific capacitance of 4800 W·kg−1 and 394 F·g−1, respectively. In terms of its capabilities as an anode within an LIB, the layered-graphene overwhelms the Li-intercalation, which is reflected in the obtained specific capacity of 150 mAh·g−1, with a columbic efficiency of ~99% (after 450 cycles) at a current of 100 mA·g−1
Spin drag measurements were performed in a two-dimensional electron system set close to the crossed spin helix regime and coupled by strong intersubband scattering. In a sample with an uncommon combination of long spin lifetime and high charge mobility, the drift transport allows us to determine the spin-orbit field and the spin mobility anisotropies. We used a random walk model to describe the system dynamics and found excellent agreement for the Rashba and Dresselhaus couplings. The proposed two-subband system displays a large tuning lever arm for the Rashba constant with gate voltage, which provides a new path towards a spin transistor. Furthermore, the data show large spin mobility controlled by the spin-orbit constants setting the field along the direction perpendicular to the drift velocity. This work directly reveals the resistance experienced in the transport of a spin-polarized packet as a function of the strength of anisotropic spin-orbit fields.
The paper discusses the new monograph, published in 2019 by V. A. Artamonov, well-known researcher of the Petrine epoch. His book is dedicated to studying the military conflict between Russia and Ottoman empire in 1710–1713. The author shows clearly that Ottoman Sultan Ahmed III and his commander in chief Mehmed Pasha had no plan of any invasions to Russia, but wanted just return to the borders before 1696 in the Priazovye region. Peter I, planning his expedition to Moldavia in 1711, did not take to consideration the experience of Austrian and Polish campaigns against Ottomans in the end of the 17th century. This led to encirclement and blockade of the Russian army by the Ottoman forces on the Pruth river (July 9–12, 1711). Under these conditions Peter I could not make a decision to fight, but preferred to negotiate peace, although Russian army was quite able to defeat enemy. The Ottoman side willingly agreed to make peace, which was supported by giving almost 300.000 Rubles to commander in chief Mehmed Pasha and his staff. After that Russia lost some fortresses in the Priazovye region and political influence on the Christian peoples under Ottoman rule in the Balkans. This monograph could be highly recommended for academic scholars, teachers and students of higher education institutions.
Poly(ADP-ribosyl)ation is a reversible post-translational modification that plays an essential role in many cellular processes, including regulation of DNA repair. Cellular DNA damage response by the synthesis of poly(ADP-ribose) (PAR) is mediated mainly by poly(ADP-ribose) polymerase 1 (PARP1). The XPC-RAD23B complex is one of the key factors of nucleotide excision repair participating in the primary DNA damage recognition.

By using several biochemical approaches, we have analyzed the influence of PARP1 and PAR synthesis on the interaction of XPC-RAD23B with damaged DNA. Free PAR binds to XPC-RAD23B with an affinity that depends on the length of the poly(ADP-ribose) strand and competes with DNA for protein binding. Using (32)P-labeled NAD(+) and immunoblotting, we also demonstrate that both subunits of the XPC-RAD23B are poly(ADP-ribosyl)ated by PARP1. The efficiency of XPC-RAD23B PARylation depends on DNA structure and increases after UV irradiation of DNA.

Therefore, our study clearly shows that XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by PARP1, which can be regarded as a universal regulator of DNA repair processes.
X chromosome inactivation is a complex process that occurs in marsupial and eutherian mammals. The process is thought to have arisen during the differentiation of mammalian sex chromosomes to achieve an equal dosage of X chromosome genes in males and females. The differences in the X chromosome inactivation processes in marsupial and eutherian mammals are considered, and the hypotheses on its origin and evolution are discussed in this review.
Photolysis of 1,3,2,4-benzodithiadiazine (1) at ambient temperature yields stable 1,2,3-benzodithiazolyl radicals. In order to reveal the mechanism of this unusual transformation, the photochemistry of 1 was studied in argon matrices using IR and UV−vis spectroscopy. A series of intermediates, including four- and five-membered heterocyclic and o-quinoid acyclic species, were characterized spectroscopically with the help of quantum chemical calculations. With selective irradiation, these intermediates can be mutually interconverted as well as converted back to the starting compound 1.
Berberine is known for its wide range of biological activity, including hypolipidemic, antibacterial, hypoglycemic, etc. Our interest is focused on the inhibitory properties of berberine and its derivatives in relation to the DNA reparation enzyme Tdp1. Inhibition of various DNA repair enzymes, including Tdp1, is one of the promising fields in the evolution of antitumor therapy. We synthesized and tested a number of berberine derivatives, which allowed us to identify leading compounds and understand which functional groups should contain a derivative and in which positions in order to exhibit inhibitory activity. According to SAR data analysis only tetrahydroberberine derivatives containing a reduced ring C show inhibitory activity. The presence of substituents in both positions simultaneously (amide or sulfonate group in 9 and bromine in 12) leads to increasing of inhibitory activity (IC50 = 0.5 – 4 µM) in comparison with unbrominated in 12 position analogues. Almost all of the most active derivatives exhibit low cytotoxicity. Thus, the results reveal that some berberine derivatives are potential agents that can be used in antitumor therapy. This study was funded by the Russian Science Foundation grantNo19-13-00040
A theoretical study of the non-equilibrium phase transition in a steam-drop medium has been carried out. The previously proposed model has been refined, taking into account the influence of the vapor phase. Comparative numerical simulation of the superheated liquid outflow was performed on thermodynamic equilibrium and non-equilibrium relaxation models of the phase transition for different times of relaxation, calculated based on the experimental data on the droplet distribution over the radius. The work has revealed the possibility of improving the model by processing the experimental data on the size distribution of drops formed during fragmentation of a boiling water jet.
ЭКСТРАХРОМОСОМНЫЕДНК В КЛЕТКАХ МОЗГА И ПЕЧЕНИ НОРМАЛЬНЫХ КРЫС

Л. В. Обухова, Е. В. Киселева, А. Ю. Боровков, В. П. Кумарев, Н
Oil transportation via trunk pipelines is an important part of the oil industry's activity.

The main instrument of tariff regulation is the method of tariffs formation. Three methods of tariffs formation such as the method of economically justified costs (the Cost plus method), the method of economically justified return on investment capital (the RAB method), and the method of tariffs indexation were considered.
Analysis of joint inheritance of symbiotic locus sym31 and 12 molecular and morphological markers of pea linkage group III was performed.

Using the AntMap software, a detailed genetic map of the sym31 locus was constructed

The linkage between symbiotic locus sym31 and 11 analyzed markers was observed and its fine position in linkage group III was determined.
Bi(iii) particles were immobilized into the cages of mesoporous chromium oxoterephthalate MIL-101.

The material obtained possesses enhanced photocatalytic activity

in comparison with bulk BiOCl synthesized under the same conditions.
We calculate in the BFKL approach the jet vertex relevant for the production of Mueller-Navelet jets in proton-proton collisions.

We consider both cases of incoming quark and gluon and show explicitly that all infrared divergences cancel when renormalized parton densities are considered.

Finally we compare our expression for the vertex with a previous calculation [1].
Highly dispersed framework NZP-type zirconium phosphates were synthesized via both sol-gel method(SG)and mechanochemical activation(MA) of solid precursors followed by their hydrothermal treatment (HTT) in the presence of surfactants.

Genesis of samples real structure and its effect on the surface properties and activity in hexane isomerization were studied.
We describe degenerations of four-dimensional binary Lie algebras, and five- and six-dimensional nilpotent Malcev algebras over ℂ.

In particular, we describe all irreducible components of these varieties.
A special aspect of parameter identification in finite‐strain elasto‐plasticity is considered. Namely, we analyze the impact of the measurement errors on the resulting set of material parameters. In order to define the sensitivity of parameters with respect to the measurement errors, a mechanics‐based distance between two sets of parameters is introduced. Using this distance function, we assess the reliability of certain parameter identification procedures. The assessment involves introduction of artificial noise to the experimental data; the noise can be both correlated and uncorrelated. An analytical procedure to speed up Monte Carlo simulations is presented. As a result, a simple tool for estimating the robustness of parameter identification is obtained. The efficiency of the approach is illustrated using a model of finite‐strain viscoplasticity, which accounts for combined isotropic and kinematic hardening. It is shown that dealing with correlated measurement errors, most stable identification results are obtained for non‐diagonal weighting matrix. At the same time, there is a conflict between the stability and accuracy.
Modern astroparticle physics makes wide use of machine learning methods in such problems as noise suppression, image recognition, event classification. When using these methods, in addition to obtaining new scientific knowledge, it is important also to take advantage of their educational potential. In this work we present a demo version of the machine-learning based application we have created, which helps students and a broader audience to get more familiar with the cosmic ray physics, and shows how machine learning methods can be used to analyze data. The work discusses the prospects for expanding the application's functionality and methodological approaches to the development of interactive outreach materials in this area.
The paper presents the results of numerical modeling of a transonic region formation in the flat channel. Hydrogen flows into the channel through the holes in the wall. The jet of compressed air is localized downstream the holes. The transonic region formation is formed by the burning of heterogeneous hydrogen-air mixture. It was considered in the framework of the simplified chemical kinetics. The interesting feature of the regime obtained is the following: the distribution of the Mach numbers is qualitatively similar to the case of pulse-periodic energy sources. This mode is a favorable prerequisite for the effective fuel combustion in the expanding part of the channel when injecting fuel into this part.
Background The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of the Drosophila CNS is frequently achieved by employing the binary Gal4/UAS system. However, many Gal4 driver lines available from the Bloomington Drosophila Stock Center (BDSC) and commonly used in Drosophila neurobiology are still not well characterized. Among these are three lines with Gal4 driven by the elav promoter (BDSC #8760, #8765, and #458), one line with Gal4 driven by the repo promoter (BDSC #7415), and the 69B-Gal4 line (BDSC #1774). For most of these lines, the exact insertion sites of the transgenes and the detailed expression patterns of Gal4 are not known. This study is aimed at filling these gaps.

Results We have mapped the genomic location of the Gal4-bearing P -elements carried by the BDSC lines #8760, #8765, #458, #7415, and #1774. In addition, for each of these lines, we have analyzed the Gal4-driven GFP expression pattern in the third instar larval CNS and eye-antennal imaginal discs. Localizations of the endogenous Elav and Repo proteins were used as markers of neuronal and glial cells, respectively.

Conclusions We provide a mini-atlas of the spatial activity of Gal4 drivers that are widely used for the expression of UAS–target genes in the Drosophila CNS. The data will be helpful for planning experiments with these drivers and for the correct interpretation of the results.
Nimorazole belongs to the imidazole-based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [
Assisted reproductive technologies (ART) increasingly occupy the study of human reproduction. In addition, in developed countries they contribute to breeding of more than 50 % of cattle. In the management of collections of genetic lines of laboratory animals, these technologies are obligatory components of cryopreservation and rederivation.

ART procedures include the development of early embryos outside the mother's body and the high probability of incomplete synchronization of the physiological state of the surrogate mother and transplanted embryos. Since all this occurs at the stage of the highest susceptibility of embryos to epigenetic reprogramming, the full cycle of ART and its individual components can lead to stable phenotypic changes in the offspring. Their reality is confirmed by studies of the morphological and functional characteristics of sexually mature offspring of CD1 outbred mice, obtained using different variants of early embryo transplantation. Comparative studies of body mass and body composition, basal glucose level and response to glucose load (glucose-tolerance test - GTT) have been done on sexually mature males and females. Animals were separated in 4 groups according to the variant of embryo transplantation: group (control) - natural mating; group (2cl-bl) - incubation of 2-cell up to blastocysts; group (2cl-2cl) - removal and transplantation of the 2-cell embryo without incubation; group (Bl-bl) removal and transplantation of the blastocysts without incubation. All embryos were transplanted to recipient females of the same line.

It was found that sexually mature offspring obtained with all variants of transplantations had a higher relative fat content and, correspondingly, lower lean mass compared to the control. This effect was more pronounced in females than in males. Unlike body compositions, embryo transplantations had a greater effect on basal glucose concentration and GTT in males than in females. In this case, the offspring of the 2cl-2cl and 2cl-bl groups were characterized by a higher tolerance to glucose load (GTT) compared with the control and the Bl-bl group. Stable deviations of body compositions and glucose homeostasis indices detected in experimental groups of progenies indicate the phenotypic significance of the embryo transplantations per se.
Association between common intelligence quotient (IQ) and S and L alleles of functional 5HTTLPR polymorphism causing respectively low and high expression of human serotonin transporter coding gene was studied in young (19-35 years, 50 men and 76 women) and older (>55 years, 39 men and 43 women) Caucasian subjects.They were students, scientists, technicians and administrative staff of Novosibirsk State Universities and State Research Institutes of Russian Academy of Sciences.Significant effects of genotype and age, but not gender on IQ were revealed.Higher IQ scores were observed in the S/S genotype carriers compared with the L/S (p<0.002) or L/L (p<0.003)genotype carriers.No effect of the genotype x gender or genotype x age interaction was found.Based on this result, we hypothesized an increased frequency of the S allele in highly educated university group compared with control population.To test this hypothesis the distribution of the alleles and genotypes in the above mentioned academic sample and control population of Caucasian subjects from Dovolnoe village, Novosibirsk region (n=83) was compared.The frequencies of the S allele (43.5%) and the S/S genotype (20.5%) in the academic sample were significantly higher than in the controls (28.2%, p=0.023 for the S allele and 10.1%, p=0.011 for the S/S genotype).The results indicate a significant association between IQ scores and the 5HTTLPR polymorphism, the involvement of serotonergic neuromodulation in cognitive functioning and provide further support for the classification of the S allele and the S/S genotype as associated with cognition.
Recent results of a high-statistics τ lepton studies at B factories are reported.

Reviewed are the measurements of Michel parameters in leptonic and radiative leptonic τ decays at Belle, as well as the measurement of the branching fractions of the radiative leptonic τ decays at BABAR.

Searches for CP symmetry violation in hadronic decays with $ \mathop K\nolimits_S^0 $ are also briefly discussed.
The article presents a variant of maturity onset diabetes of the young type 2, caused by a rare mutation in the GCK gene. Maturity onset diabetes of the young (MODY) is a hereditary form of diabetes with an autosomal dominant type of inheritance, an onset at a young age, and a primary defect in pancreatic β-cell function. This type of diabetes is different from classical types of diabetes mellitus (DM1 and DM2) in its clinical course, treatment strategies, and prognosis. Clinical manifestations of MODY are heterogeneous and may vary even among members of the same family, i. e., carriers of identical mutations. This phenotypic variation is due to the interaction of mutations with different genetic backgrounds and the influence of environmental factors (e. g., lifestyle). Using next-generation sequencing technology, the c.580–1G>A substitution (IVS5 –1G>A, rs1554335421) located in an acceptor splice site of intron 5 of the GCK gene was found in a proband. The identified variant cosegregated with a pathological phenotype in the examined family members. The GCK gene encodes glucokinase (hexokinase 4), which catalyzes the first step in a large number of glucose metabolic pathways such as glycolysis. Mutations in this gene are the cause of MODY2. The illness is characterized by an insignificant increase in the fasting glucose level, is a well-controlled disease without medication, and has a low prevalence of micro- and macrovascular complications of diabetes. The presented case of MODY2 reveals the clinical significance of a mutation in the splice site of the GCK gene. When nonclassical diabetes mellitus is being diagnosed in young people and pregnant women, genetic testing is needed to verify the diagnosis and to select the optimal treatment method.
The production ratios are compared to the predictions of several Monte Carlo generator settings, none of which are able to describe adequately all observables.

The charged-particle production ratios are measured with the LHCb detector using pp collisions delivered by the LHC at different energies. The measurements are performed as a function of transverse momentum and pseudorapidity.

The ratio bar/p is considered as a function of rapidity loss and is used to constrain models of baryon transport.
Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for $H\to\textrm{invisible}$ decays where $H$ is produced according to the Standard Model via vector boson fusion, $Z(\ell\ell)H$, and $W\!/\!Z(\textrm{had})H$, all performed with the ATLAS detector using 36.1 fb$^{-1}$ of $pp$ collisions at a center-of-mass energy of $\sqrt s = 13$ TeV at the LHC. In combination with the results at $\sqrt s = 7$ and 8 TeV, an exclusion limit on the $H\to\textrm{invisible}$ branching ratio of $0.26 (0.17^{+0.07}_{-0.05})$ at 95% confidence level is observed (expected).