Hengzongshu/ArticleAgent huggingface dataset:
Similar to regularly spaced nucleosomes in chromatin, long tandem DNA arrays are composed of regularly alternating monomers that have almost identical primary DNA structures. Such a similarity in the structural organization makes these arrays especially interesting for studying the role of intrinsic DNA preferences in nucleosome positioning.

We have studied the nucleosome formation potential of DNA tandem repeat families with different monomer lengths (ML). In total, 165 plant tandem repeat families from the PlantSat database (http://w3lamc.umbr.cas.cz/PlantSat/) were divided into two classes based on the number of nucleosome repeats in one DNA monomer. For predicting nucleosome formation potential, we developed the Phase method, which combines the advantages of multiple bioinformatics models. The Phase method was able to distinguish interfamily differences and intrafamily monomer variation and identify the influence of nucleotide context on nucleosome formation potential.

Three main types of nucleosome arrangement in DNA tandem repeat arrays – regular, partially regular (partial), and flexible – were distinguished among a great variety of Phase profiles. The regular type, in which all nucleosomes of the monomer array are positioned in a context-dependent manner, is the most representative type of the class 1 families, with ML equal to or a multiple of the nucleosome repeat length (NRL). In the partially regular type, nucleotide context influences the positioning of only a subset of nucleosomes. The influence of the nucleotide context on nucleosome positioning has the least effect in the flexible type, which contains the greatest number of families (65). The majority of these families belong to class 2 and have nonmultiple ML to NRL ratios.
Operation of a plasma source with a hot disk cathode and a cylindrical hollow anode in axial magnetic field is sensitive to the cathode-to-anode diameter ratio. When the cathode edge maps along magnetic field lines to the inner anode surface, the discharge voltage is relatively low, and the plasma stream with moderate density occupies the entire cross-section of the anode bore. By contrast, when the cathode projection is fully inside the anode bore with the radial cathode-to-anode gap ∼ 1 cm, the discharge voltage jumps to much higher values exceeding 250 V. The plasma density profile becomes Gaussian-like with the width matching the cathode radius according to magnetic flux surfaces. The plasma density in the high-voltage cross-field discharge reaches 1013 cm−3, and the discharge parameters almost do not change with magnetic field up to 1.5 kG in the anode area. This plasma source is suitable for the use in linear devices for plasma-material interaction studies.
Fasting has become increasingly popular for treatment and prevention of obesity. Sex differences in the mechanisms of adaptation to fasting may contribute to choosing a therapeutic strategy for correction of metabolic disorders. Hepatokine fibroblast growth factor 21 (FGF21) is involved in the adaptation to fasting. Muscles are assumed to be the main energy-consuming tissue in the body, as muscle metabolism plays an important role in the adaptation to nutritional deficit. However, there is still little information on sex differences in muscle and FGF21 physiological response to fasting.

Our aim was to find out whether there were sex differences in hormonal regulation and the expression of genes controlling glucose and lipid metabolism in skeletal muscles in response to fasting. We estimated the effect of 24-hour fasting on the expression of genes involved in lipid (Ucp3, Cpt1) and carbohydrate (Slc2a4) metabolism in muscles and evaluated changes in body weight and blood plasma levels of glucose, insulin, free fatty acids (FFA), adiponectin, and FGF21 in male and female C57BL/6J mice.

None of the genes studied (Ucp3, Cpt1 and Slc2a4) showed sex-related changes at mRNA levels in control groups, but females exposed to fasting demonstrated a significant increase in the expression of all genes as compared to control. Fasting significantly decreased body weight and glucose blood plasma levels in animals of both sexes but exerted no effect on the levels of insulin or FFA. The adiponectin and FGF21 levels were increased in response to fasting, the increase in females being significant. We were first to show sex dimorphism in muscle gene expression and FGF21 blood level in response to fasting. In females, the greater increase in FGF21 and adiponectin blood levels was positively associated with the greater upregulation of lipid oxidation and glucose uptake gene expression.
Mesozoic (125–135 Ma) cratonic low-Ti lamproites from the northern part of the Aldan Shield do not conform to typical classification schemes of ultrapotassic anorogenic rocks.

Here we investigate their origins by analyzing olivine and olivine-hosted inclusions from the Ryabinoviy pipe, a well preserved lamproite intrusion within the Aldan Shield. Four types of olivine are identified: (1) zoned phenocrysts, (2) high-Mg, high-Ni homogeneous macrocrysts, (3) high-Ca and low-Ni olivine and (4) mantle xenocrysts. Olivine compositions are comparable to those from the Mediterranean Belt lamproites (Olivine-1 and -2), kamafugites (Olivine-3) and leucitites. Homogenized melt inclusions (MIs) within olivine-1 phenocrysts have lamproitic compositions and are similar to the host rocks, whereas kamafugite-like compositions are obtained for melt inclusions within olivine-3. Estimates of redox conditions indicate that “lamproitic” olivine crystallized from anomalously oxidized magma (∆NNO +3 to +4 log units.). Crystallization of “kamafugitic” olivine occurred under even more oxidized conditions, supported by low V/Sc ratios.

We consider high-Ca olivine (3) to be a fingerprint of kamafugite-like magmatism, which also occurred during the Mesozoic and slightly preceded lamproitic magmatism. Our preliminary genetic model suggests that low-temperature, extension-triggered melting of mica- and carbonate-rich veined subcontitental lithospheric mantle (SCLM) generated the kamafugite-like melts. This process exhausted carbonate and affected the silicate assemblage of the veins. Subsequent and more extensive melting of the modified SCLM produced volumetrically larger lamproitic magmas. This newly recognized kamafugitic “fingerprint” further highlights similarities between the Aldan Shield potassic province and the Mediterranean Belt, and provides evidence of an overlap between “orogenic” and “anorogenic” varieties of low-Ti potassic magmatism. Moreover, our study also demonstrates that recycled subduction components are not an essential factor in the petrogenesis of low-Ti lamproites, kamafugites and leucitites.
The article is dedicated to the analysis of the global optimization algorithms application to the solution of inverse problems of chemical kinetics. Two heuristic algorithms are considered - the gravitational search algorithm and the harmony algorithm.

The article describes the algorithms, as well as the application of these algorithms to the optimization of test functions. After that, these algorithms are used to search for the kinetic parameters of two chemical processes - propane pre-reforming on Ni-catalyst and catalytic isomerization of pentane-hexane fraction.

For the first process both algorithms showed approximately the same solution, while for the second problem the gravitational search algorithm showed a smaller value of the minimizing function. Wherefore, it is concluded that on large-scale problems it is better to use the gravitational search algorithm rather than the harmony algorithm, while obtaining a smaller value of the minimizing function in a minimum time. On low-scale problems both algorithms showed approximately the same result, while demonstrating the coincidence of the calculated data with the experimental ones.
Статья посвящена исследованию места и особенностей такого нового института в договорном праве России, как смарт-контракт.Исследован зарубежный опыт по этой тематике
The existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the light vector mediator of this dark force, the $\mathrm{U}$ boson, with the KLOE detector at the DA$\Phi$NE $\mathrm{e}^{+}\mathrm{e}^{-}$ collider. Using an integrated luminosity of 1.54 fb$^{-1}$, we studied the process $\mathrm{e}^{+}\mathrm{e}^{-} \to \mathrm{U}\gamma$, with $\mathrm{U} \to \mathrm{e}^{+}\mathrm{e}^{-}$, using radiative-return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90\%~CL upper limit on the mixing strength between the Standard Model photon and the dark photon, $\varepsilon^2$, at $10^{-6}$--$10^{-4}$ in the 5--520~MeV/c$^2$ mass range.
In this study, the dependence of the catalytic activity of highly oriented pyrolytic graphite (HOPG)-supported bimetallic Pd-Au catalysts towards the CO oxidation based on the Pd/Au atomic ratio was investigated.

The activities of two model catalysts differing from each other in the initial Pd/Au atomic ratios appeared as distinctly different in terms of their ignition temperatures. More specifically, the PdAu-2 sample with a lower Pd/Au surface ratio (~0.75) was already active at temperatures less than 150 °C, while the PdAu-1 sample with a higher Pd/Au surface ratio (~1.0) became active only at temperatures above 200 °C. NAP XPS revealed that the exposure of the catalysts to a reaction mixture at RT induces the palladium surface segregation accompanied by an enrichment of the near-surface regions of the two-component Pd-Au alloy nanoparticles with Pd due to adsorption of CO on palladium atoms. The segregation extent depends on the initial Pd/Au surface ratio.

The difference in activity between these two catalysts is determined by the presence or higher concentration of specific active Pd sites on the surface of bimetallic particles, i.e., by the ensemble effect. Upon cooling the sample down to room temperature, the reverse redistribution of the atomic composition within near-surface regions occurs, which switches the catalyst back into inactive state. This observation strongly suggests that the optimum active sites emerge under reaction conditions exclusively, involving both high temperature and a reactive atmosphere.
Temozolomide (TMZ) is a conventional chemotherapy drug for adjuvant treatment of glioblastoma multiforme (GBM), often accompanied by dexamethasone (DXM) to prevent brain oedema and alleviate clinical side effects. Here, we aimed to investigate an ability of the drugs to affect normal brain tissue in terms of proteoglycan (PG) composition/content in experimental rat model in vivo. Age- and brain zone-specific transcriptional patterns of PGs were demonstrated for 8, 60, and 120 days old rats, and syndecan-1, glypican-1, decorin, biglycan, and lumican were identified as the most expressed PGs. DXM treatment affected both PG core proteins expression (mainly syndecan-1, glypican-1, decorin, biglycan, lumican, versican, brevican, and NG2) and heparan sulphate (HS)/chondroitin sulphate (CS) content in organotypic brain slice culture ex vivo and experimental animals in vivo in a dose-dependent manner. TMZ treatment did not result in the significant changes in PG core proteins expression both in normal rat brain hippocampus and cortex in vivo (although generics did), but demonstrated significant effects onto polysaccharide HS/CS content in the brain tissue. The effects were age- and brain zone-specific and similar with the age-related PGs expression changes in rat brain. Combination of TMZ with DXM resulted in the most profound deterioration in PGs composition and content in the brain tissue both at core protein and glycosaminoglycan levels. Taken together, the obtained results demonstrate that conventional anti-glioblastoma therapy affects proteoglycan structure and composition in normal brain tissue, potentially resulting in deterioration of brain extracellular matrix and formation of the favourable tumorigenic niche for the expansion of the residual glioma cells. During the TMZ chemotherapy, dose and regimen of DXM treatment matter, and repetitive low DXM doses seem to be more sparing treatment compared with high DXM dose(s), which should be avoided where possible, especially in combination with TMZ.
We estimated the polarization contribution of Coulomb energy to the spacing between the ground and first excited state of the 229Th nucleus as a function of the deformation parameter δ.

To extract the full value of ΔUC, we propose to measure isomeric shift of atomic levels and nuclear electric quadrupole moments in 229Th.

We show that despite the fact that the odd particle is a neutron, the change in Coulomb energy ΔUC between these two states can reach several hundreds keV from this contribution. This means that the effect of the variation of the fine-structure constant may be enhanced ΔUC/E∼104 times in the E=7.6 eV 'nuclear clock' transition between the ground and first excited states in the 229Th nucleus.
The paper presents the results of experimental measurements of the emission properties of water plasma in an inductive discharge. The power of the inductive discharge was 600 W at a frequency of 27 MHz and a pressure from 0.25 to 4 mbar. Plasma temperature was estimated from the Balmer hydrogen series using relative intensities method. It is shown that in this pressure range, the plasma is not in equilibrium and the energy difference between individual excited states increased with distance from the tube axis. The plasma heating time was estimated from the dynamics of the spectral line intensities to be 200 ms.
We considered and analyzed the finds of iron arrowheads from a small collection of armament objects for long-range combat related to the epoch of Kyrgyz Great Power. The collection is exhibited at the moment in the National Museum of the Kyrgyz Republic in Bishkek City. Results. Precise location of these objects is not determined. However, it is known that all these objects of armament originate from the territory of modern Kyrgyzstan. The arrowheads from the collection have been preserved quite well, which distinguishes these findings from the armament objects of excavations of archaeological monuments of the cultures of ancient and medieval peoples in the Tian Shan.

Having carried out a formal and typological classification analysis of the items from the collection, we determined a certain typological identity of the armament for longrange combat that were related to different groups and types of iron petiolate arrowheads according to the section and the form of feather. We found analogues to the arrows from our collection when discovered arrowheads of similar forms as a part of weapon complexes of ancient and medieval ethnicities inhabiting the Central Asian historical and cultural region during the Ancient times, Early and High Middle Ages. We traced the spread of arrowheads of different types, analyzed them as a part of our collection, and analyzed the items discovered in the course of previous research in medieval archaeological sites on the territory of northern Tian Chan Region in the bounds of Kyrgyzstan.

The results of our analysis prove that all the arrowheads from the collection studied relate to the historical eras of the Early and High Middle Ages. A part of this collection is likely to have belonged to the complex of means for long-range combat. They used such arrowheads while shooting the enemy in the epoch of the Kyrgyz Khanate. Preponderance of armorpiercing and versatile iron arrowheads can testify the necessity to confront enemies in long-range combats and fight against adversaries who were powerfully armed and fully-equipped with metallic armor.
The review highlights contemporary concepts about the role of atmospheric air pollution by particulate matter (PM) in pathogenesis of cardiovascular diseases (CVD). We used publications from the PubMed and Russian Science Citation Index databases. The influence of PM on the development and progression of CVD is considered depending on size, origin, chemical composition, concentration in air. PM with an aerodynamic diameter of ≤2,5 μm (PM2,5) are recognized as the most dangerous. Epidemiological studies have established a dose-dependent effect PM. Oxidative stress, damage of genome of cell and epigenetic changes associated with PM effect are the important component of CVD pathogenesis. Systematization of scientific data through a formalized description helps to understand the pathogenesis of CVD and facilitates its practical use for assessing the risk of occurrence, early diagnosing, prognostication, increasing the effectiveness of treatment, and developing preventive measures.
Multiple DNA repair pathways may be involved in the removal of the same DNA lesion caused by endogenous or exogenous agents. Although distinct DNA repair machinery fulfill overlapping roles in the repair of DNA lesions, the mechanisms coordinating different pathways have not been investigated in detail. Here, we show that Ku70, a core protein of nonhomologous end‐joining (NHEJ) repair pathway, can directly interact with DNA polymerase‐β (Pol‐β), a central player in the DNA base excision repair (BER), and this physical complex not only promotes the polymerase activity of Pol‐β and BER efficiency but also enhances the classic NHEJ repair. Moreover, we find that DNA damages caused by methyl methanesulfonate (MMS) or etoposide promote the formation of Ku70‐Pol‐β complexes at the repair foci. Furthermore, suppression of endogenous Ku70 expression by small interfering RNA reduces BER efficiency and leads to higher sensitivity to MMS and accumulation of the DNA strand breaks. Similarly, Pol‐β knockdown impairs total‐NHEJ capacity but only has a slight influence on alternative NHEJ. These results suggest that Pol‐β and Ku70 coordinate 2‐way crosstalk between the BER and NHEJ pathways.—Xia, W., Ci, S., Li, M., Wang, M., Dianov, G. L., Ma, Z., Li, L., Hua, K., Alagamuthu, K. K., Qing, L., Luo, L., Edick, A. M., Liu, L., Hu, Z., He, L., Pan, F., Guo, Z. Two‐way crosstalk between BER and c‐NHEJ repair pathway is mediated by Pol‐β and Ku70. FASEB J. 33, 11668‐11681 (2019). www.fasebj.org
A metallic wire embedded in the dielectric substrate leads to frustration of the total internal reflection at the interface between dielectric and free space. The scattering by a gold cylinder is studied in order to exploit the light for hidden objects optical diagnostics. The p-wave incidenting by the angle close to total reflection with the frequency near plasmonic resonance is treated by the modified boundary elements method. The magnetic and electric fields at the interface are calculated. The scattering diagrams are found in near and far field.
Seven different approaches to the phenomenological finite-strain viscoelasticity are analyzed. The focus of the analysis is put on the Maxwell fluid, due to its paramount importance for phenomenological material modeling.

The first modeling approach to the Maxwell fluid is based on the multiplicative decomposition of the deformation gradient, combined with hyperelastic relations between stresses and elastic strains. The second approach employs the additive decomposition of the strain rate tensor in combination with hypoelastic relations. The third approach makes use of the additive decomposition of the material Hencky strain. The fourth and fifth models are the covariant and contravaraint models of the Maxwell fluid, proposed by Haupt and Lion (2002). Finally, the sixth and the seventh approaches are the modifications of these two models, introduced here to enforce a pure volumetric-isochoric split.

The approaches are analyzed with respect to their objectivity, thermodynamic consistency, fading memory, weak invariance under isochoric change of the reference configuration, and a possibility of a pure volumetric-iscohoric split.
The article describes geological structure, characteristics and gold content of eluvium-talus deposit of 'Golets Visochayshiy' field, according to data from previous geological reports and data

received by author during his work on this deposit
Sensing infrared radiation is done inexpensively with pyroelectric detectors that generate a temporary voltage when they are heated by the incident infrared radiation. Unfortunately the performance of these detectors deteriorates for longer wavelengths, leaving the detection of, for instance, millimetre-wave radiation to expensive approaches.

We propose here a simple and effective method to enhance pyroelectric detection of the millimetre-wave radiation by combining a compact commercial infrared pyro-sensor with a metasurface-enabled ultra-thin absorber, which provides spectrally- and polarization-discriminated response and is 136 times thinner than the operating wavelength. An in-depth electromagnetic analysis of the ultra-thin resonant absorbers along with their complex characterization by a BWO-spectroscopy technique is presented. Built upon this initial study, integrated metasurface absorber pyroelectric sensors are implemented and tested experimentally.

It is demonstrated that, due to the small thickness and therefore the thermal capacity of the absorber, the detector keeps the high response speed and sensitivity to millimetre waves as the original infrared pyro-sensor does against the regime of infrared detection. showing high sensitivity and very fast response to millimetre-wave radiation. The proposed approach paves the way for creating highly-efficient inexpensive compact sensors for spectro-polarimetric applications in the millimetre-wave and terahertz bands.
Estimation of functional connectivity in gene sets derived from genome-wide or other biological experiments is one of the essential tasks of bioinformatics. A promising approach for solving this problem is to compare gene networks built using experimental gene sets with random networks. One of the resources that make such an analysis possible is CrossTalkZ, which uses the FunCoup database. However, existing methods, including CrossTalkZ, do not take into account individual types of interactions, such as protein/protein interactions, expression regulation, transport regulation, catalytic reactions, etc., but rather work with generalized types characterizing the existence of any connection between network members. We developed the online tool FunGeneNet, which utilizes the ANDSystem and STRING to reconstruct gene networks using experimental gene sets and to estimate their difference from random networks. To compare the reconstructed networks with random ones, the node permutation algorithm implemented in CrossTalkZ was taken as a basis. To study the FunGeneNet applicability, the functional connectivity analysis of networks constructed for gene sets involved in the Gene Ontology biological processes was conducted. We showed that the method sensitivity exceeds 0.8 at a specificity of 0.95. We found that the significance level of the difference between gene networks of biological processes and random networks is determined by the type of connections considered between objects. At the same time, the highest reliability is achieved for the generalized form of connections that takes into account all the individual types of connections. By taking examples of the thyroid cancer networks and the apoptosis network, it is demonstrated that key participants in these processes are involved in the interactions of those types by which these networks differ from random ones. FunGeneNet is a web tool aimed at proving the functionality of networks in a wide range of sizes of experimental gene sets, both for different global networks and for different types of interactions. Using examples of thyroid cancer and apoptosis networks, we have shown that the links over-represented in the analyzed network in comparison with the random ones make possible a biological interpretation of the original gene/protein sets. The FunGeneNet web tool for assessment of the functional enrichment of networks is available at http://www-bionet.sscc.ru/fungenenet/ .