Hengzongshu/ArticleAgent huggingface dataset:
The research topic is the increasing process of electricity generation based on renewable energy sources (RES) in the Russian Federation and its regions. This paper aims to develop a methodology for modeling new RES technologies in the initial period of their dissemination. Its application allows to estimate the scale of energy generation in the regions fr om the standpoint of national economy efficiency. The research methodology includes the application of parametric analysis in the framework of interregional input-output model of optimization with detailed energy sector. Its essence is to increase step by step the cost of a new RES technology in the competitive environment of traditional technologies until it leaves the optimal plan. The parametric process involves finding the threshold values of the RES technology cost in the region, passing by which the technology changes its intensity (efficiency) dramatically. A comparative retrospective analysis of RES technologies spreading in the country and regions is carried out. It is shown the importance of taking into account the installed capacity utilization factor when modeling technologies. Formal procedures for embedding it in energy technologies of the model are described. The trajectories of integrated effects fr om spreading of renewable energy technologies, obtained as a result of parametric analysis, can be ranked by region and used for selective investment policy on the part of the state. It should be aimed at supporting the development of energy on RES primarily in those regions wh ere the maximum integral effect is obtained.
Performance of flash radiography units implies a high spatial resolution. Thus, focused electron beams are utilized to produce bremsstrahlung x-ray at the solid target. Strong heating of the target up to 1-10 eV temperature and formation of dense plasma can lead to beam disruption. In case of multi-pulse operation mode of radiography unit the plasma produced by the first pulse can strongly affect subsequent pulses.

In present work we utilize the model of Zeldovich and Raizer to estimate the electron density in the target plasma. The typical parameters of radiography units based on linear induction accelerators is considered.

It is shown that electron density in plasma expanding after first pulse is high enough to affect subsequent electron beams.
Small supernumerary marker chromosomes (sSMC) are detected in 0.043% of general population and can be characterized for their chromosomal origin, genetic content and shape by molecular cytogenetic approaches. Even though recently progress was achieved towards genotype-phenotype-correlations of sSMC, nothing is known on the influence that an additional derivative extra chromosome has on the nuclear architecture.Here we present the first three-dimensional interphase fluorescence in situ hybridization (FISH) studies for the nuclear architecture of sSMC. It could be shown that sSMC derived from chromosomes 15, 16 or 18 preferentially colocalized with one of their corresponding sister chromosomes. This was true in B- and T-lymphocytes as well as in skin fibroblasts. Additionally, a case with a complex sSMC with a karyotype 47,XY,+der(18)t(8;18)(8p23.2 ~ 23.1;18q11.1) was studied. Here the sSMC co-localized with one homologous chromosome 8 instead of 18.Overall, there is a kind of "attraction" between an sSMC and one of its homologous sister chromosomes. This seems to be transmitted by the euchromatic part of the sSMC rather than its heterochromatic one.
Metagenomic surveys of human microbiota are becoming increasingly widespread in academic research as well as in food and pharmaceutical industries and clinical context. Intuitive tools for exploration of experimental data are of high interest to researchers.

Knomics-Biota is a Web-based resource for exploratory analysis of human gut metagenomes. Users can generate analytical reports that correspond to common experimental schemes (like case-control study or paired comparison).

Statistical analysis and visualizations of microbiota composition are provided in association with the external factors and in the context of thousands of publicly available datasets. Availability and Implementation The Web-service is available at https://biota.knomics.ru .
The prosecutive-comparative case in the Khakass language, as well as in some other Turkic languages of Southern Siberia, has the meaning of lengthwise direction, a line. The given value is not expressed by any specialized grammatical form for the majority of Turkic languages, which makes its study important. The localizer is an important component of the analysis when functions and semantics of spatial cases are described.

The article is aimed at revealing the structure of the localizers expressed by names or a combination of names which are used in the prosecutive-comparative case in the Khakass language. The analysis of the structure of such localizers shows that the space is characterized, basically, by two types: the extended space having some extent and a big space, with an extensive area.

Thus, the prosecutive-comparative case in the Khakass language expresses relations not only as lines or lengthwise directions, but also as a general place of movement.
// Lora E. Bakeeva 1 , Chupalav M. Eldarov 1 , Irina M. Vangely 1 , Nataliya G. Kolosova 2,3 and Valeriya B. Vays 1 1 Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Leninskie Gory, Moscow, Russia 2 Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Pr. Acad. Lavrentieva, Novosibirsk, Russia 3 Novosibirsk State University, Novosibirsk, Russia Correspondence to: Natalia G. Kolosova, email: // Keywords : aging, dry eye syndrome, ultrastructure of lacrimal gland, mitochondria, mitochondria-targeted antioxidant, Gerotarget Received : April 27, 2016 Accepted : November 02, 2016 Published : November 11, 2016 Abstract Dry eye syndrome is an eye disorder affecting many people at an old age. Because dry eye syndrome is accelerated by aging, a useful approach to the prevention of this syndrome may be an intervention into the aging process. Previously, we showed that the mitochondria-targeted antioxidant SkQ1 delays manifestations of aging and inhibits the development of age-related diseases including dry eye syndrome. Nevertheless, the link between SkQ1's effects and its suppression of age-related changes in the lacrimal gland remains unclear. Here we demonstrated that dietary supplementation with SkQ1 (250 nmol/[kg body weight] daily) starting at age 1.5 months significantly alleviated the pathological changes in lacrimal glands of Wistar rats by age 24 months. By this age, lacrimal glands underwent dramatic deterioration of the ultrastructure that was indicative of irreversible disturbances in these glands' functioning. In contrast, in SkQ1-treated rats, the ultrastructure of the lacrimal gland was similar to that in much younger rats. Morphometric analysis of electron-microscopic specimens of lacrimal glands revealed the presence of numerous secretory granules in acinar cells and a significant increase in the number of operating intercalary ducts. Our results confirm that dietary supplementation with SkQ1 is a promising approach to healthy ageing and to prevention of aberrations in the lacrimal gland that underlie dry eye syndrome.
The results of using an adapted sampling algorithm by the Monte Carlo method to estimate the ambiguity domain of the inversion of synthetic dispersion curves of the phase velocities of surface waves using artificial neural networks are discussed in the paper. The expediency of using the considered algorithm for calculating a probabilistic estimate of the results of the inverse problem solution in the method of multichannel analysis of surface waves has been confirmed.
This article analyzes the relations between the energy intensity of the economy and the amount of pollutant emissions in the atmosphere. The authors reviewed the main global trends in the field of emissions of pollutants and energy intensity of the economy. The authors also determined the specifics of the Russian economy regarding the structure of energy consumption and the main directions of energy intensity reduction. The study analyzed key indicators of the energy intensity of the economy, the structure and dynamics of consumption of traditional fossil fuels and renewable energy sources. The problems of the growth of pollutant emissions in Russia were considered also. The authors analyzed the dynamics of the emission of pollutants by the main sources of pollution: industrial sectors and automobile transport. The article also analyzed the structure of the growth of pollutant emissions in industries (mining, manufacturing, production and distribution of electricity, gas and water), as well as in road transport. An important aspect in the field of improving the environmental efficiency of production and reducing emissions of pollutants in the atmosphere is the cost of protecting the environment. The main trends in changing the level of environmental protection costs in industrial sectors were identified. Based on the analysis, the authors made conclusions about the nature of the growth of pollutant emissions in industry and road transport based on the analysis.
A finitely generated group G acting on a tree so that all vertex and edge stabilizers are infinite cyclic groups is called a generalized Baumslag–Solitar group (GBS group). Such an action is described by a labeled graph. One GBS group can be presented by many labeled graphs.

We study the embedding problem for GBS groups: to determine algorithmically when two given labeled graphs 𝔸 1 and 𝔸 2 define GBS groups G 1 and G 2 such that G 1 is embeddable into G 2.

We prove that if G 1 can be presented by only a finite number of reduced labeled graphs, then the embedding problem is solvable. Moreover, we describe the algorithm in this situation.
We measure the mass difference, \Delta m_0, between the D*(2010)+ and the D0 and the natural line width, \Gamma, of the transition D*(2010)+ -> D0 pi+. The data were recorded with the BABAR detector at center-of-mass energies at and near the Upsilon(4S) resonance, and correspond to an integrated luminosity of approximately 477 1/fb. The D0 is reconstructed in the decay modes D0 -> K- pi+ and D0 -> K- pi+ pi- pi+. For the decay mode D0 -> K- pi+ we obtain Gamma = (83.4 +- 1.7 +- 1.5) keV and \Delta m_0 = (145 425.6 +- 0.6 +- 1.8) keV, where the quoted errors are statistical and systematic, respectively. For the D0 -> K- pi+ pi- pi+ mode we obtain \Gamma = (83.2 +- 1.5 +- 2.6) keV and \Delta m_0 = (145 426.6 +- 0.5 +- 2.0) keV. The combined measurements yield \Gamma = (83.3 +- 1.2 +- 1.4) keV and \Delta m_0 = (145 425.9 +- 0.4 +- 1.7) keV; the width is a factor of approximately 12 times more precise than the previous value, while the mass difference is a factor of approximately 6 times more precise.
The spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis compromises effective control of tuberculosis (TB) in Siberia. Early identification of drug-resistant isolates is, therefore, crucial for effective treatment of this disease.

The aim of this study was to conduct drug susceptibility testing and identify mutations in drug resistance genes in clinical isolates of M. tuberculosis from some TB patients presenting for treatment in Siberia. Thirty randomly selected clinical isolates of M. tuberculosis were obtained from the Novosibirsk Research Institute of Tuberculosis, Russia. Isolates were screened for drug resistance and characterized by variable number of tandem repeats (VNTR)-typing using 15 standard and four additional loci. Deligotyping on multiple large sequences was performed using 10 loci. Gene sequences (rpoB, katG, rrs, rpsL, tlyA, gidB, gyrA, gyrB) were analyzed to identify mutations that confer resistance to rifampicin, isoniazid, amikacin, kanamycin, capreomycin, and ofloxacin.

Twenty-nine of the isolates were assigned XDR status. Twenty-eight isolates belonged to the M. tuberculosis Beijing family, from which 11 isolates were considered the M11 type (39%), two the M2 type (7%), and one the M33 type (3%). Seventeen isolates (60.7%) from this family exhibited unique genetic patterns. The remaining two isolates belonged to the Latino-American Mediterranean family. The most common mutations among the XDR isolates were S531L in RpoB, S315T in KatG, various codon 94 mutations in gyrA, A90V in GyrA, K43R in RpsL, and 1401 A → G in rrs; these confer resistance to rifampicin, isoniazid, ofloxacin, streptomycin and kanamycin/capreomycin, respectively. There was high congruence between the two typing methods (VNTR typing and deligotyping) and RD105, RD149, RD152, RD181, and RD207 regions of difference were absent from the 28 Beijing family isolates. Deligotyping can be used for rapid and reliable screening of M. tuberculosis isolates, followed by more in-depth genotyping. Identification of Beijing family isolates with extensive drug resistance confirms that such strains have epidemiological importance in Siberia. Rapid detection of mutations that lead to drug resistance should facilitate selection of effective drug therapies, and the development of early prevention strategies to combat this infection.
Genome-wide gene expression maps with a high spatial resolution have substantially accelerated molecular plant science. However, the number of characterized tissues and growth stages is still small because of the limited accessibility of most tissues for protoplast isolation. Here, we provide gene expression profiles of the mature inflorescence stem of Arabidopsis thaliana covering a comprehensive set of distinct tissues. By combining fluorescence-activated nucleus sorting and laser-capture microdissection with next generation RNA sequencing, we characterize transcriptomes of xylem vessels, fibers, the proximal and the distal cambium, phloem, phloem cap, pith, starch sheath, and epidermis cells. Our analyses classify more than 15,000 genes as being differentially expressed among different stem tissues and reveal known and novel tissue-specific cellular signatures. By determining transcription factor binding regions enriched in promoter regions of differentially expressed genes, we furthermore provide candidates for tissue-specific transcriptional regulators. Our datasets predict expression profiles of an exceptional amount of genes and allow generating hypotheses toward the spatial organization of physiological processes. Moreover, we demonstrate that information on gene expression in a broad range of mature plant tissues can be established with high spatial resolution by nuclear mRNA profiling. One sentence summary A genome-wide high-resolution gene expression map of the Arabidopsis inflorescence stem is established.
Spike shape and morphometric characteristics are among the key characteristics of cultivated cereals associated with their productivity. Identification of the genes controlling these traits requires morphometric data at harvesting and analysis of numerous plants, which could be automatically done using technologies of digital image analysis.

A method for wheat spike morphometry utilizing 2D image analysis is proposed. Digital images are acquired in two variants: a spike on a table (one projection) or fixed with a clip (four projections). The method identifies spike and awns in the image and estimates their quantitative characteristics (area in image, length, width, circularity, etc.). Section model, quadrilaterals, and radial model are proposed for describing spike shape. Parameters of these models are used to predict spike shape type (spelt, normal, or compact) by machine learning.

The mean error in spike density prediction for the images in one projection is 4.61 (~18%) versus 3.33 (~13%) for the parameters obtained using four projections.
One of the key elements of terahertz time-domain spectrometers is the optical delay line. Usually it consists of a motorized translation stage and a corner reflector mounted on its top. Errors in the positioning of the translation stage lead to various distortions of the measured waveform of terahertz pulses and, therefore, terahertz spectra. In this paper, the accuracy of position measurements is improved by using an optical encoder. Three types of systematic errors are found: Increasing and periodic offsets of the translation stage position, as well as a drift of its initial position in a series of consecutive measurements. The influence of the detected errors on the measured terahertz spectra is studied and correction methods are proposed.
In this study, the dependence of the catalytic activity of highly oriented pyrolytic graphite (HOPG)-supported bimetallic Pd-Au catalysts towards the CO oxidation based on the Pd/Au atomic ratio was investigated. The activities of two model catalysts differing from each other in the initial Pd/Au atomic ratios appeared as distinctly different in terms of their ignition temperatures. More specifically, the PdAu-2 sample with a lower Pd/Au surface ratio (~0.75) was already active at temperatures less than 150 °C, while the PdAu-1 sample with a higher Pd/Au surface ratio (~1.0) became active only at temperatures above 200 °C. NAP XPS revealed that the exposure of the catalysts to a reaction mixture at RT induces the palladium surface segregation accompanied by an enrichment of the near-surface regions of the two-component Pd-Au alloy nanoparticles with Pd due to adsorption of CO on palladium atoms. The segregation extent depends on the initial Pd/Au surface ratio. The difference in activity between these two catalysts is determined by the presence or higher concentration of specific active Pd sites on the surface of bimetallic particles, i.e., by the ensemble effect. Upon cooling the sample down to room temperature, the reverse redistribution of the atomic composition within near-surface regions occurs, which switches the catalyst back into inactive state. This observation strongly suggests that the optimum active sites emerge under reaction conditions exclusively, involving both high temperature and a reactive atmosphere.
We previously have described the "3+1" tumors cure approach consisting of individual time schedule of cyclophosphamide and dsDNA preparation administrations. The aim of the study was to adapt the "3+1" approach based on eradication of cancer stem cells to the model of murine ascitic cyclophosphamide-resistant lymphosarcoma (RLS).

Adaptation of the "3+1" approach includes the identification of the timing to disrupt the tumorigenic potential of a certain tumor.

The proposed therapeutic scheme allowed complete reduction of primary RLS ascites in experimental animals. However, reduction of primary ascites due to the complementary action of cyclophosphamide and dsDNA was inevitably followed by the development of a secondary one, most likely arising from a solid carcinomatous formation in the peritoneal wall. The "3+1" approach resulted in the elimination of cancer stem cells, and, as a consequence, in the complete reduction of RLS ascites.
Background: fracture risks assessment and determination of bone mineral density are modern methods, generally accepted and widely used. However, they have limitations and disadvantages for the dynamic evaluation of bone remodeling processes in RA-patients with low BMD. The investigation of bone resorption markers is an important issue.

Aims: to compare the antiresorptive activity of denosumab and alendronic acid in patients with rheumatoid arthritis and osteoporosis using β-CTX and osteocalcin (OC). Materials and methods: forty-two patients were included in the study (16 patients were treated with denosumab, 13 patients – with alendronic acid, 13 patients - control group without any osteoporosis treatment). The quantitative determination of β-CTX and OC as well as dual-energy X-ray absorptionometry (DXA) were carried out for all patients at the first visit with consecutive investigation of bone resorption markers 3 months after. The predictive capacity was determined using the ratio of observed fractures/expected fractures by FRAX.

Results: The level of β-CTX 16% (median 861.6 pg/ml vs. 724.6 pg/ml, p = 0.049) and OC 39% (median 13.9 ng/ml vs 8.5 ng/ml, p = 0.047) decreased significantly in 3 month in RA patients treated with denosumab. The decrease of β-CTX (median 858.9 pg/ml vs. 821.8 pg/ml) and OC (median 14.8 ng/ml vs. 13.9 ng/ml) was observed in the group of patients treated with alendronic acid, but not reached statistical significance. Conclusions: denosumab had showed better antiresorptive activity compared with bisphosphonates, which was registered 3 month after the start of the treatment.
Objective. To study in cross-sectional research the association of actual nutrition with estimates of cognitive function (CF) in the population of men and women of middle and older age (45–69 years).

Materials and methods . The study was conducted in the framework of the international project HAPIEE on a random subsample (2,159 men, 2,525 women) of residents of Novosibirsk. Evaluation of CF was carried out using standard methods (test for direct reproduction of 10 words, test for speech activity (associative thinking) and test for delayed reproduction). Nutrition data was obtained from population surveys in the HAPIEE project using a questionnaire to assess the frequency of food consumption. Statistical data processing was performed using the SPSS 13.0 application package. The GLM procedure was used, allowing to take into account the influence of related factors. Differences were considered statistically significant at p < 0.05.

Results . The presence of a significant correlation between the actual nutrition with standardization by age, body mass index and level of education with CF estimates was found. It has been shown that higher consumption of fruits and vegetables was significantly associated with higher scores in both men and women. Women, unlike men, also showed significantly higher CF estimates for consumption of rice, meat products and dairy products. In addition, there was a negative association of CF with the consumption of a number of products. Men showed a significant decrease in the estimates of CF with the consumption of sugar and fats; in women, in the consumption of white bread, sugar and fat. Conclusion : the results of our study showed the presence of a significant association of CF estimates with the level of consumption of a number of products, both positive and negative, in middle-aged and older people. These data may be useful in the development of nutritional recommendations for the prevention of violations of CF.
The study of sorption and transport characteristics of a composite sorbent based on various types of glass microspheres is carried out. In order to carry out this research, an experimental stand has been prepared for measuring sorbent characteristics at specified pressure and temperature values. The technique of carrying out the experiment and processing the experimental data for the purpose of determining the helium permeability of composite sorbents with a filler made of different material: sodium borosilicate glass, silica microspheres, cenospheres has been worked out. The values of the helium permeability of the composite sorbent in the temperature range from 20 to 140 °C are determined. The transport characteristics of the medium formed by the granules of the composite sorbent, as well as the values of the characteristic time of helium sorption by the composite sorbent are found.