Hengzongshu/ArticleAgent huggingface dataset:
The number Ka= N / N 1 is used to evaluate the thermal power of a plume; N is the thermal power transferred from the plume base to its conduit, and N 1 is the thermal power transferred from the plume conduit into the surrounding mantle. At the relative thermal power 1.9

Based on laboratory and theoretical modeling data, we present the flow structure of melt in the conduit and the head of the thermochemical plume. The features of melting in the plume conduit are elucidated on the basis of the phase diagram of the CaO-MgO-Al 2 O 3 -SiO 2 model system. The two upper convection cells of the plume conduit relate to the region of basic and ultrabasic compositions. Our study shows that melting in these cells proceeds according to monovariant equilibria of eutectic type L=Cpx+Opx+An+Sp and L=Fo+An+Cpx+Opx. In case of the CaO–MgO–Al 2 O 3 –SiO 2 –Na 2 O system, crystallization differentiation proceeds as separation of plagioclase crystals. Separation of plagioclase crystals enriched in anorthite component leads to enrichment of the residual melt in silica and alkaline components. Assuming the initial basaltic melt, we calculated the compositional changes in the melt, which are powered by the heat and mass transfer processes in the mushroom-shaped plume head. The calculations were performed in two stages: (1) after settling of refractory minerals; (2) after settling of plagioclase in the melt resulting from the first stage. In the second stage, the melt contains 88.5 % of plagioclase component. The calculations were performed for melt temperature T melt =1410 °C and pressure P =2.6 kbar and 6.3 kbar.

The calculated weight contents of oxides, the normative compositions for solid phase, and the oxide content and normative composition for the residual melt were tabulated. The SiO 2 content in the residual melt amounts to 59.6–62.3 % and corresponds to the crustal SiO 2 content.
Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial reference genome sequence reported more than a decade ago had a profound impact on progress in Drosophila research, and improving the accuracy and completeness of this sequence continues to be important to further progress. We previously described improvement of the 117-Mb sequence in the euchromatic portion of the genome and 21 Mb in the heterochromatic portion, using a whole-genome shotgun assembly, BAC physical mapping, and clone-based finishing. Here, we report an improved reference sequence of the single-copy and middle-repetitive regions of the genome, produced using cytogenetic mapping to mitotic and polytene chromosomes, clone-based finishing and BAC fingerprint verification, ordering of scaffolds by alignment to cDNA sequences, incorporation of other map and sequence data, and validation by whole-genome optical restriction mapping. These data substantially improve the accuracy and completeness of the reference sequence and the order and orientation of sequence scaffolds into chromosome arm assemblies. Representation of the Y chromosome and other heterochromatic regions is particularly improved. The new 143.9-Mb reference sequence, designated Release 6, effectively exhausts clone-based technologies for mapping and sequencing. Highly repeat-rich regions, including large satellite blocks and functional elements such as the ribosomal RNA genes and the centromeres, are largely inaccessible to current sequencing and assembly methods and remain poorly represented. Further significant improvements will require sequencing technologies that do not depend on molecular cloning and that produce very long reads.
Background: Effortful control is a core aspect of self-regulation and refers to the ability to voluntarily regulate behaviour and attention, measured by temperament questionnaires. Although the Temperament in Middle Childhood Questionnaire is widely used in different countries, this measure has not been fully explored. Most research on the links of effortful control with personality and important outcomes has been carried out in Western nations; the possibility of extending these findings to other cultures requires study.
AP endonuclease 1 (APE1) is a crucial enzyme of the base excision repair pathway (BER) in human cells. APE1 recognizes apurinic/apyrimidinic (AP) sites and makes a nick in the phosphodiester backbone 5' to them. The conformational dynamics and presteady-state kinetics of wild-type APE1 and its active site mutant, Y171F-P173L-N174K, have been studied. To observe conformational transitions occurring in the APE1 molecule during the catalytic cycle, we detected intrinsic tryptophan fluorescence of the enzyme under single turnover conditions. DNA duplexes containing a natural AP site, its tetrahydrofuran analogue, or a 2'-deoxyguanosine residue in the same position were used as specific substrates or ligands. The stopped-flow experiments have revealed high flexibility of the APE1 molecule and the complexity of the catalytic process. The fluorescent traces indicate that wild-type APE1 undergoes at least four conformational transitions during the processing of abasic sites in DNA. In contrast, nonspecific interactions of APE1 with undamaged DNA can be described by a two-step kinetic scheme. Rate and equilibrium constants were extracted from the stopped-flow and fluorescence titration data for all substrates, ligands, and products. A replacement of three residues at the enzymatic active site including the replacement of tyrosine 171 with phenylalanine in the enzyme active site resulted in a 2 x 10(4)-fold decrease in the reaction rate and reduced binding affinity. Our data indicate the important role of conformational changes in APE1 for substrate recognition and catalysis.
The article proposes a new method for solving the equations of motion of charged particles in electromagnetic fields. In the algorithm, the velocity of a charged particle at a time step is computed in accordance with the exact solution of the differential equation. The method has been compared with various known modifications of the Boris method. The comparison was carried out both in terms of the accuracy of the methods and the time of their operation. A new modification of the method uses the fact that the electric and magnetic fields are constant at a time step. It allows one to compute more accurately the trajectory and velocity of a charged particle without significant increasing the complexity of the computations. It has been shown that when choosing a modification of the Boris method to solve a problem, one should pay attention first of all to the accuracy of the solution, since a simpler and faster scheme may not give a gain in time.
Following a recent work by C. Bai, O. Bellier, L. Guo, and X. Ni (arXiv:1106.6080) we define what is a dendriform di- or trialgebra in an arbitrary variety Var of algebras (associative, commutative, Poisson, etc.).

We prove that every dendriform dialgebra in Var can be embedded into a Rota---Baxter algebra of weight zero in the same variety, and every dendriform trialgebra can be embedded into a Rota---Baxter algebra of nonzero weight.

We prove that every dendriform dialgebra in Var can be embedded into a Rota---Baxter algebra of weight zero in the same variety, and every dendriform trialgebra can be embedded into a Rota---Baxter algebra of nonzero weight.
Waves of finite amplitude on a thin layer of non-Newtonian fluid modelled as a power-law fluid are considered. In the long wave approximation, the system of equations taking into account the viscous and nonlinear effects has the hyper- bolic type. For the two-parameter family of periodic waves in the film flow on a vertical wall the modulation equations for nonlinear wave trains are derived and investigated. The stability criterium for roll waves based on the hyperbolicity of the modulation equations is suggested. It is shown that the evolution of stable roll waves can be described by self-similar solutions of the modulation equations.
Acousto-optic diffraction of terahertz vortex beams was studied for the first time. It was shown that nonpolar liquids are the most promising acousto-optic media in the terahertz range.

Experimental research was performed for cyclohexane, hexane and white spirit. The experiments were carried out at the Novosibirsk free-electron laser.

Possibility of vortex beam wide-angle deflection was demonstrated.
The recombination kinetics of the biochemically prominent radicals NO and O2− to form ONOO− (“peroxynitrite”) is sensitive to high magnetic fields, as shown by U. E. Steiner, D. V. Stass et al. on on p. 1714.
The experimental investigation of water droplet deformation (characteristic dimensions 3 ÷ 6 mm) when moving through the gas area (air) with 1÷ 5 m/s velocities was carried out.

The high-speed (delay time between the frames is less than 100 ns) tools of cross-correlation videorecording were used.

A cyclic change nature of the droplet shapes (from close to spherical to conditionally ellipsoidal) was found. The characteristic times of 'deformation cycles' and the maximal deviations of droplet dimensions relative to initial dimensions were determined. The influence of droplet velocities and its dimensions on the deformation characteristics was determined.
The 2nd TAIGA imaging air Cherenkov telescope (IACT) has successfully been put into operation in the Tunka Valley in fall 2020. Currently three more telescopes are under construction and completion. The ability to use the telescopes in the so-called stereo mode of image analysis by taking into account the unusually large distance between them (from 320 m to 500 m), well exceeding the inter-telescope distances in conventional IACT stereo systems, is being explored and discussed. The results of the dedicated Monte Carlo are compared with the experiment data from the 1st and the 2nd TAIGA-IACT.
The nano oxides (TeO) x (Mo,V,Nb) 5 O 14 with so-called M1 structure are highly attractive objects due to unsurpassed catalytic properties. In situ X-ray powder diffraction method with high time resolution (0.4 seconds per diffraction pattern) was applied to study the structure stability and the mechanism of phase transformation under heating in the reductive conditions. It was shown that M1 structure gradually transforms into the rutile-type (Mo,V,Nb)O 2 phase without intermediate phases and/or amorphisation at temperatures >480°C in a reductive media. The process is initiated by tellurium reduction and its sublimation to the gas phase.
A search for doubly charged scalar bosons decaying into W boson pairs is presented. It uses a data sample from proton-proton collisions corresponding to an integrated luminosity of 36.1 fb -1 collected by the ATLAS detector at the LHC at a centre-of-mass energy of 13 TeV in 2015 and 2016.

This search is guided by a model that includes an extension of the Higgs sector through a scalar triplet, leading to a rich phenomenology that includes doubly charged scalar bosons H±±. Those bosons are produced in pairs in proton-proton collisions and decay predominantly into electroweak gauge bosons H±±→W±W±. Experimental signatures with several leptons, missing transverse energy and jets are explored.

No significant deviations from the Standard Model predictions are found. The parameter space of the benchmark model is excluded at 95% confidence level for H±± bosons with masses between 200 and 220 GeV.
Iron complexes with chiral bipyrrolidine-derived aminopyridine (PDP) ligands are among the most efficient Fe-based bioinspired catalysts for regio- and stereoselective oxidation of C–H and C═C moieties with hydrogen peroxide. Besides hydrogen peroxide, other oxidants (peroxycarboxylic acids and organic hydroperoxides) can be effectively used.

In this work, we have examined the mechanistic landscape of the Fe(PDP) catalyst family with various oxidants: H2O2, organic hydroperoxides, and peracids. The combined EPR spectroscopic, enantioselectivity, Hammett, Z-stilbene epoxidation stereoselectivity, and 18O-labeling data witness that the same oxoiron complexes [(L)FeV═O(OC(O)R)]2+ are the actual epoxidizing species in both the catalyst systems (L)Fe/H2O2/carboxylic acid and (L)Fe/AlkylOOH/carboxylic acid.

On the contrary, in the systems (L)Fe/R2C(O)OOH (R2 = CH3 or 3–Cl-C6H4), in the presence or in the absence of carboxylic acid, the epoxidation is predominantly conducted by the acylperoxo-iron(III) intermediates [(L)FeIII(OOC(O)R2)]2+, in a concerted fashion.
Background: TNF-alpha act as main proinflamantory cytokine in rheumatoid arthritis (RA) immune processes. However, TNF-alpha activity and functions may be regulate not only by soluble receptors (which act as decoys) but also by number, density, and co-expression of its membrane-bound receptors type 1 and 2 (TNFR1 and TNFR2).

Methods: PBMC were analyzed from 46 HD and 64 patients with RA using flow cytometry. Patients were divided according to the DAS-28 index into groups with high (n=22, 34.4%), moderate (n=30, 46.9%) and low (n=12, 18.8%) disease activity. Co-expression of TNFR1/2 was evaluated as percentage of cell with different receptors. Number of receptors of each type per cell was counted using QuantiBrite PE beads (BD, USA). The following populations were analyzed: total monocyte pool; common pool of B lymphocytes; common pool of T lymphocytes; cytotoxic T cells (CD8+), T helper cells (CD4+), activated (CD25+) cells among CD8+ and CD4+, T memory (CD45R0+) and naïve T cells (CD45RA+) among cytotoxic and T helper cells; T regulatory cells (CD4+CD25highCD127low); B1 cells (CD45+CD19+CD5+).

Results: We found that analyzed cell populations differ significantly in the co-expression of type 1 and 2 receptors for TNFα both between each other and compared to healthy donors. The most pronounced differences between groups of patients in the expression profile were shown for B cells, T reg and memory cells (figure). The total proportion of cells with at least one type of receptors was significantly decreased as compared with HD (in the case of B cells, T-helper memory cells) or increased (in the case of naive cytotoxic T cells, naïve T helper cells, monocytes, T regs). This indicator may reflect the overall sensitivity of the cells of the subpopulation to the effects of cytokine. This mechanism may reflect the ability of the cells to react on certain TNF-alpha concentration or anti-cytokine therapy. Conclusion: The profile of TNFR1\2 co-expression is changed in RA compared to heath. RA disease activity is associated with the changes in the amount and co-expression of type 1 and type 2 receptors for TNF-alpha on the surface of immunocompetent cells.
The OO coupling process in water oxidation on the gamma FeOOH hydroxide catalyst is simulated by means of density functional theory using model iron cubane cluster Fe 4 O 4 (OH) 4 . A key reactive intermediate is proposed to be the HOFe IV O• oxyl unit with terminal oxo radical.

The “initial” vertex Fe III (OH) moiety forms this intermediate at the calculated overpotential of 0.93 V by adding one water molecule and withdrawing two proton–electron pairs. The OO coupling goes via water nucleophilic attack on the oxyl oxygen to form the OO bond with a remarkably low barrier of 11 kcal/mol.

This process is far more effective than alternative scenario based on direct interaction of two ferryl Fe IV O sites (with estimated barrier of 36 kcal/mol) and is comparable with the coupling between terminal oxo center and three‐coordinated lattice oxo center (12 kcal/mol barrier). The process of hydroxylation of terminal oxygen inhibits the OO coupling. Nevertheless, being more effective for ferryl oxygen, the hydroxylation in fact enhances selectivity of the OO coupling initiated by the oxyl oxygen.
Using a human cDNA expression array, we obtained expression profiles of 588 genes in CD14+ monocytes and monocyte-derived dendritic cells (DCs). Overall, 22 genes were upregulated, and nine genes were downregulated in DCs of both samples from two different individuals. Many of the genes that were upregulated in DCs encode proteins that are related to differentiation, cell structure, migration, termination of cell cycle as well as proliferation, e.g. tumour necrosis factor-alpha (TNF-alpha), tumour necrosis factor receptor II (TNFRII), thymosin beta-10, epithelial discoidin domain receptor 1, replication factor C, putative transcription factor DB1, alpha catenin, transforming growth factor-beta 1, prohibitin, p53-regulating protein and neu differentiation factor. Among the downregulated genes in DCs were genes that encode proteins of cell cycle regulation: mitotic growth and transcription activator, platelet-derived growth factor receptor-beta subunit, interleukin 2 receptor (IL-2R)-gamma subunit, IL-7R-alpha subunit, leucocyte interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR). Semi-quantitative reverse transcription-polymerase chain reaction method confirmed the upregulated expression levels in DCs for TNFRII, TNF-alpha, alpha catenin and downregulation of IFN-gamma, GM-CSFR on four different donor samples of DCs and monocytes. Moreover, our data show the presence of a 'switch-on' step for the TNF-alpha and TNFRII gene expression in immature DCs for further differentiation into mature DCs.
КОРРЕКЦИЯ КОГНИТИВНЫХ НАРУШЕНИЙ С ИСПОЛЬЗОВАНИЕМ ТРЕНИРУЮЩЕГО ВОЗДЕЙСТВИЯ НА РЕЧЕВЫЕ ДОМЕНЫ МОЗГАЕ. М. Зубрицкая
It is an almost consensus opinion that the major carcinogenic risk of tobacco smoke is in its direct mutagenic action on DNA of cancer-related genes. The key data supposedly linking smoke-induced mutations to lung cancer were obtained from the adduct spectrum of the p53 tumor suppressor gene. Results of our analysis of p53 mutations compiled from the International Agency for Research on Cancer p53 database (April 1999 update) and from the literature point to a different causative link. Our new analytical tests focused on complementary base substitutions and showed that it is strand-specific repair of primary lesions and site-specific selection of the resultant mutations that determine the lung cancer-specific hot spots of G:C to T:A transversions along the p53 gene and also their increased abundance in lung tissues as compared with smoke-inaccessible tissues. However, on each of the two strands of p53 DNA, our tests revealed no significant difference between smokers and nonsmokers, either in the frequency of different types of mutations or in the frequency of their occurrence along the p53 gene. Moreover, in both smokers and nonsmokers, there was the same frequency of lung tumors with silent p53 mutations. Accordingly, we offer here a selection-based explanation of why lung cancers with nonsilent p53 mutations are more common in smokers than in nonsmokers. We conclude that physiological stresses (not necessarily genotoxic) aggravated by smoking are the leading risk factor in the p53-associated etiology of lung cancer.
Bottom baryons decaying to a J/ψ meson and a hyperon are reconstructed using 1.0 fb(-1) of data collected in 2011 with the LHCb detector.

Significant Λ(b)(0) → J/ψΛ, Ξ(b((-) → J/ψΞ(-) and Ω(b)(-) → J/ψΩ(-) signals are observed and the corresponding masses are measured.

These are the most precise mass measurements of the Λ(b)(0), Ξ(b)(-) and Ω(b)(-) baryons to date. Averaging the above Λ(b)(0) mass measurement with that published by LHCb using 35 pb(-1) of data collected in 2010 yields M(Λ(b)(0)) = 5619.44 ± 0.13(stat.)± 0.38(syst.) MeV/c(2).
RNA interference (RNAi) using exogenous double-stranded RNA (dsRNA) has been used to silence the model gene of Nicotiana benthamiana phytoendesaturase.

Here we report on an efficient technique for dsRNA synthesis using E. coli HT115 strain. This strain is deficient in RNase III, an enzyme that normally destroys most dsRNA in a bacterial cell and has been engineered to produce big quantities of dsRNA. We also used root treatment for dsRNA delivery to N. benthamiana plants.

We found this method to be one of the most efficient ways to deliver dsRNA for plants.
The dynamics of photodissociation of PCl3 at 235 nm has been studied by monitoring of ground state Cl(2P3/2) and spin-orbitally excited Cl(2P1/2) atoms by REMPI technique. Also, the P+, PCl+, PCl+, and PCl+ photoions have been monitored non-resonantly in parallel with detection of REMPI-produced Cl+ ions. The speed distributions and speed-dependent anisotropy ± parameters β for all these particles have been determined by three-dimensional photofragment ion imaging technique. The β parameters are close to zero for all these particles. The relative yields of excited Cl(2P1/2) atoms for photodissociation of PCl3 is 0.49 0.03. The speed distributions of Cl(2P3/2) and Cl(2P1/2) atoms are bimodal. We explain the bimodal distributions as a result of competition between two REMPI channels. One channel is far-from-resonance one-photon photodissociation, the another channel is near-resonant two-photon ionisation followed by near-resonance one-photon photodissociation.
To study factors of endothelial dysfunction in order to find their associations with coagulation factors, inflammatory markers and unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis.

The study included men with coronary atherosclerosis without acute coronary syndrome. We assessed blood concentrations of endothelial dysfunction factors (endothelin 1, monocyte chemoattractant protein-1 (MCP-1), adhesion molecules sVCAM-1, asymmetric dimethylarginine, homocysteine, plasminogen activator inhibitor-1) blood coagulation (factor II, factor VII, factor XII, antithrombin III), biomarkers of inflammation (tumor necrosis factor alpha, interleukins (IL-1-beta, IL-6, IL-8), C-reactive protein).

The presence of unstable atherosclerotic plaques was associated with an increased blood level of MCP-1 (1,9 times higher; p<0,05) and a reduced concentration of sVCAM-1 (1,4 times lower; p<0,05) compared with men who withiut unstable plaques in the coronary arteries. The largest number of correlations was found between the level of MCP-1 in blood, concentrations of factor VII, antithrombin III, IL-8, C-reactive protein, IL-1 beta and the presence of unstable atherosclerotic plaques in men. The results showed that the relative risk of unstable atherosclerotic plaques in the coronary arteries is associated with an increased level of MCP-1 in the blood.
Old Testament frightening theophanies of an incomprehensible divinity, protected from the gaze of mortals by fi re, smoke, and light 1 and prophecies on the future spiritual enlightenment of God's people were fulfi lled in the New Testament theology of the Incarnation as the coming of the true light into the world (John 1: 4-9) 2 and the revelation of the radiant face of God to the disciples in the Transfi guration on Mount Tabor.The theology of the First Ecumenical Council of Nicaea on the single substance of the Son and the Father is formulated in the language of a metaphor of light, and becomes an integral part of Christian life and liturgy in the words of the Nicaean-Constantinopolitan Creed. 3 The Christian mystical tradition also witnessed multiple occasions, when God revealed himself to ascetics in the form of light.

This article att empts at demonstrating several distinct traditions of the vision of light and vision of an anthropomorphic divinity, their interac-