Hengzongshu/ArticleAgent huggingface dataset:
Aim: To determine gender differences in the relationship between depression and self-rated health and awareness of measures for cardiovascular prevention in an open population of 25-4 years in Russia/Siberia (Novosibirsk).

Methods: Under the screening based on the budgetary theme No. AAAA-A17-117112850280-2, a random representative sample of the male and female population who were residents in one of the districts in Novosibirsk was examined in 2013-2016 (n=975, 43.8% males, mean age 34.5±0.4 years). Selfassessment of health and awareness of preventive measures was assessed using the questionnaire 'Knowledge and attitude to own health'. Depression was assessed using the depression scale based on the adapted MMPI questionnaire.

Results: There was a linear increase in the proportion of those who considered themselves 'not entirely healthy' or 'sick' with an increase in the level of depression in 25-34 and 35-44 years age groups of studied population. Women aged 35-44 years with a moderate level of depression are 15-20% more likely than men to report that they are 'not entirely healthy' and 'sick' and have health complaints (p <0.05). Men aged 25-34y with major depression were more likely to report negative self-esteem and health complaints but these differences were not statistically significant. In both age groups, with an increase in the level of depression by 20-40%, the proportion of people who 'clearly did not take care of their health' among men and women increased. However, the presence of depression eliminate statistical gender differences. In the presence of depression, women are 16% more likely than men to consider it highly likely to develop a serious illness in the next 5-10 years, while they are 10% less likely to have regular health checks. Women were 4-12% more likely than men to doubt the possibilities of preventive medicine, regardless of the level of depression. Conclusions: As depression rises, self-rated health falls and confidence in the effectiveness of preventive measures among both sexes decreases. And while women are more likely to report pessimistic responses to health and prevention, the presence of high levels of depression deletes gender differences.
Backgr ound. The basic approach to the production of new common wheat genotypes involving introgressive hybridization entails a long-term process. Doubled haploid production could accelerate it. However, this method is not widely used in breeding programs due to its main limitation: the genotype dependence. Due to genetic differences between wheat and related species, it was assumed that alien genetic materials are different in their capacity to affect androgenesis. The effect of alien translocations on androgenesis has been shown earlier.

The plant material included: the spring wheat cultivar ‘Novosibirskaya 16’, line Velut 991 carrying wheat-alien translocations 1RS.1BL from rye and 5BS.5BL-5SL from Aegilops speltoides Tausch, and four hybrid F3 generation lines (10-7, 14-8, 15-8, 15-12) from their crossing, differing in the content of alien translocations.

It was shown that parameters of androgenesis such as the number of embryo-like structures per 100 anthers, the number of albino regenerants per 100 anthers, and the number of green regenerants per 100 anthers varied depending on the line. The best -responding lines Velut 991, 10-7 and 14-8 are characterized by the presence of a 1RS.1BL wheat-rye translocation chromosome. Regeneration frequency of green plants was recorded to be 8,6%, 3,6% and 10,1% respectively. The values of the parameters for lines 15-12 (carrying 5BS.5BL-5SL translocation) and 15-8 (without translocations) did not differ significantly. Therefore, it can be concluded that the presence of the introgressive fragment of chromosome 5S did not affect the efficiency of androgenesis and the short shoulder of chromosome 1R carries genes that stimulated androgenesis in anther culture.
The article describes the first stage of the realization of a complex psycholinguistic associative experiment in French and Russian. The aim of this experiment is to identify associative fields of words describing the attitude of young people towards multiculturalism, academic mobility and internationalization of higher education in target cities – Novosibirsk and Tomsk in Siberia (Russia), Montpellier and Bordeaux in France. The associative experiment will supplement sociological and other studies and will allow us to show the respondents’ naive views on various words describing certain aspects of students’ life. Associative experiments are considered to be a reliable method to identify conscious and unconscious meanings of words. Thus, the “language consciousness of the individual” (a concept introduced by Moscow School of Psycholinguistics, describing the language of an individual or a community from a psycholinguistic point of view) becomes visible to the external observer. The analysis of the most stable and repetitive reactions of a large number of participants makes it possible to infer the collective opinion. After processing the results of the experiment, a fragment of the associative network modeling the lexicon of French and Russian students in this subject area will be obtained.
The inclusive top quark pair ($t\bar{t}$) production cross-section $\sigma_{t\bar{t}}$ has been measured in proton$-$proton collisions at $\sqrt{s}=13$ TeV, using $36.1$ fb$^{-1}$ of data collected in 2015$-$16 by the ATLAS experiment at the LHC. Using events with an opposite-charge $e\mu$ pair and $b$-tagged jets, the cross-section is measured to be: \begin{equation}\nonumber \sigma_{t\bar{t}} = 826.4 \pm 3.6\,\mathrm{(stat)}\ \pm 11.5\,\mathrm{(syst)}\ \pm 15.7\,\mathrm{(lumi)}\ \pm 1.9\,\mathrm{(beam)}\,\mathrm{pb}, \end{equation} where the uncertainties reflect the limited size of the data sample, experimental and theoretical systematic effects, the integrated luminosity, and the LHC beam energy, giving a total uncertainty of 2.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. It is used to determine the top quark pole mass via the dependence of the predicted cross-section on $m_t^{\mathrm{pole}}$, giving $m_t^{\mathrm{pole}}=173.1^{+2.0}_{-2.1}$ GeV. It is also combined with measurements at $\sqrt{s}=7$ TeV and $\sqrt{s}=8$ TeV to derive ratios and double ratios of $t\bar{t}$ and $Z$ cross-sections at different energies. The same event sample is used to measure absolute and normalised differential cross-sections as functions of single-lepton and dilepton kinematic variables, and the results compared with predictions from various Monte Carlo event generators.
Some plant species have 'melanin-like' black seed pigmentation. However, the chemical and genetic nature of this 'melanin-like' black pigment have not yet been fully explored due to its complex structure and ability to withstand almost all solvents. Nevertheless, identification of genetic networks participating in trait formation is key to understanding metabolic processes involved in the expression of 'melanin-like' black seed pigmentation. The aim of the current study was to identify differentially expressed genes (DEGs) in barley near-isogenic lines (NILs) differing by allelic state of the Blp (black lemma and pericarp) locus.RNA-seq analysis of six libraries (three replicates for each line) was performed. A total of 957 genome fragments had statistically significant changes in expression levels between lines BLP and BW, with 632 fragments having increased expression levels in line BLP and 325 genome fragments having decreased expression. Among identified DEGs, 191 genes were recognized as participating in known pathways. Among these were metabolic pathways including 'suberin monomer biosynthesis', 'diterpene phytoalexins precursors biosynthesis', 'cutin biosynthesis', 'cuticular wax biosynthesis', and 'phenylpropanoid biosynthesis, initial reactions'. Differential expression was confirmed by real-time PCR analysis of selected genes.Metabolic pathways and genes presumably associated with black lemma and pericarp colour as well as Blp-associated resistance to oxidative stress and pathogens, were revealed. We suggest that the black pigmentation of lemmas and pericarps is related to increased level of phenolic compounds and their oxidation. The effect of functional Blp on the synthesis of ferulic acid and other phenolic compounds can explain the increased antioxidant capacity and biotic and abiotic stress tolerance of black-grained cereals. Their drought tolerance and resistance to diseases affecting the spike may also be related to cuticular wax biosynthesis. In addition, upregulated synthesis of phytoalexins, suberin and universal stress protein (USP) in lemmas and pericarps of the Blp carriers may contribute to their increased disease resistance. Further description of the DEGs haplotypes and study of their association with physiological characteristics may be useful for future application in barley pre-breeding.
In this review, the author analyses the Tarnovo Edition of the Stishnoy Prologue. Texts: Lexical Index (published by Bulgarian researchers Georgi Petkov and Maria Spasova) and focuses on the structure of the publication, providing a detailed description of the parts of each volume: prologue texts, prologue poems, the lexical index, and the index of saints’ names. The review evaluates the work from the point of view of its academic contribution. The reviewer largely agrees with the authors’ point of view on the history and the study of the Stishnoy Prologue set forth in the preface to the publication. While objecting to some points, the reviewer evaluates the work highly, considering it an important stage in the process of studying the history of the Stishnoy Prologue, one of the most widespread hagiographic calendar collections of the Middle Ages. The publication of the texts of the Stishnoy Prologue, even those in just the Tarnovo edition, can be a powerful catalyst for further textual criticism and linguistic studies of the numerous Russian, Serbian, and Bulgarian copies that have survived to the present day. Ultimately, the reviewed publication can become the basis for a full-scale critical edition of the Stishnoy Prologue. The review emphasises the timeless significance of this publication for Slavic studies, its innovative character, its structural integrity, its theoretical sophistication, and the enormous practical importance of the work for Bulgarian philologists.
Skeletal muscle is the principal contributor to exercise-induced changes in human metabolism. Strikingly, although it has been demonstrated that a lot of metabolites accumulating in blood and human skeletal muscle during an exercise activate different signaling pathways and induce the expression of many genes in working muscle fibres, the systematic understanding of signaling-metabolic pathway interrelations with downstream genetic regulation in the skeletal muscle is still elusive.

Herein, a physiologically based computational model of skeletal muscle comprising energy metabolism, Ca2+, and AMPK (AMP-dependent protein kinase) signaling pathways and the expression regulation of genes with early and delayed responses was developed based on a modular modeling approach and included 171 differential equations and more than 640 parameters.

The integrated modular model validated on diverse including original experimental data and different exercise modes provides a comprehensive in silico platform in order to decipher and track cause-effect relationships between metabolic, signaling, and gene expression levels in skeletal muscle.
Gene-based association analysis is an effective gene mapping tool. Many gene-based methods have been proposed recently. However, their power depends on the underlying genetic architecture, which is rarely known in complex traits, and so it is likely that a combination of such methods could serve as a universal approach. Several frameworks combining different gene-based methods have been developed. However, they all imply a fixed set of methods, weights and functional annotations. Moreover, most of them use individual phenotypes and genotypes as input data.

Here, we introduce sumSTAAR, a framework for gene-based association analysis using summary statistics obtained from genome-wide association studies (GWAS). It is an extended and modified version of STAAR framework proposed by Li and colleagues in 2020. The sumSTAAR framework offers a wider range of gene-based methods to combine. It allows the user to arbitrarily define a set of these methods, weighting functions and probabilities of genetic variants being causal. The methods used in the framework were adapted to analyse genes with large number of SNPs to decrease the running time. The framework includes the polygene pruning procedure to guard against the influence of the strong GWAS signals outside the gene. We also present new improved matrices of correlations between the genotypes of variants within genes. These matrices estimated on a sample of 265,000 individuals are a state-of-the-art replacement of widely used matrices based on the 1000 Genomes Project data.

Our framework allows the user to arbitrarily define a set of the methods and functional annotations. Moreover, we adopted the methods for the analysis of genes with a large number of SNPs to decrease the running time. The framework includes the polygene pruning procedure to guard against the influence of the strong GWAS signals outside the gene. We also present new improved matrices of correlations between the genotypes of variants within genes, which now allows to include ultra-rare variants in analysis.
Russian medical schools are currently incorporating evidence-based medicine (EBM) principles into their curricula. However, many medical schools still lack ancillary courses on research methods, epidemiology, biostatistics, etc., that result in reportedly poor quality of medical research in Russia.1 2 Many reasons for the difficulties have been identified, including linguistic barriers, lack of expertise, limited international collaboration, and inadequate allocation of resources.

The collaborative education program was created between the Department of Anesthesiology, Keck School of Medicine at the University of Southern California (KSOM, USA) and the Department of Anesthesiology, School of Medicine and Psychology at the Novosibirsk State University (NSU, Russia). The EBM course included 18 seminars and journal clubs on biostatistics, clinical epidemiology, research methodology and other aspects of EBM. Classes were transmitted through video chat from KSOM to NSU, were voluntary and held in English. The course evaluation took place at the conclusion of the first year and consisted of two questionnaires.

Based on prior publications,1 2 some Russian medical schools lack an EBM curriculum. By surveying a general medical student population, we found a discrepancy between the current and desired level of understanding of EBM indicating an unmet need. Currently, students feel insecure in applying EBM principles and have a deficiency in reading medical literature, especially in English. The EBM course, one component of an international education program, was established to create a scientific-centered learning environment, to provide expertise in EBM, and to help students overcome linguistic barrier. The participant evaluations showed that the course addressed positively the demonstrated needs of students and improved their reading and understanding of medical literature. We present evidence that reflects need for and benefits of including EBM in the medical curriculum. These findings indicate that international collaboration enhanced the medical students' educational experience by augmenting previously unavailable curricular content and should be continued.
To study the influence of microwave irradiation on two-dimensional electrons, we apply a method based on capacitance measurements in GaAs quantum well samples where the gate covers a central part of the layer.

We find that the capacitance oscillations at high magnetic fields, caused by the oscillations of thermodynamic density of states, are not essentially modified by microwaves. However, in the region of fields below 1 T, we observe another set of oscillations, with the period and the phase identical to those of microwave-induced resistance oscillations.

The phenomenon of microwave-induced capacitance oscillations is explained in terms of violation of the Einstein relation between conductivity and the diffusion coefficient in the presence of microwaves, which leads to a dependence of the capacitor charging on the anomalous conductivity. We also observe microwave-induced oscillations in the capacitive response to periodic variations of external heating. These oscillations appear due to the thermoelectric effect and are in antiphase with microwave-induced resistance oscillations because of the Corbino-like geometry of our experimental setup.
Thermocapillary deformations of horizontal self-rewetting layer of liquid (solution of 1-butanol of 5% concentration in water) when heated from a localized hot spot were studied experimentally. Measurements of the liquid layer deformations were performed using the confocal techniques with three-dimensional positioning system having high-speed linear actuator. Effect of equalizing the profile of the liquid surface over the heating area has been observed before the layer breakdown. The potential interest of the proposed studies induces by the large number of possible industrial applications, including space technologies and terrestrial applications, such as cooling of electronic components.
A nontrivial smooth steady incompressible Euler flow in three dimensions with compact support is constructed. Another uncommon property of this solution is the dependence between the Bernoulli function and the pressure.
Petrophysical properties of volcanic rocks were investigated on the North-Eastern fumarolic field of the volcano Ebeko.

The attempt is made to use this data in order to interpret the geo-electrical cross sections of the fumarolic field subsurface space.
Reaction of pinocarvone oxime with enamines and FeCl3 or CuCl2 resulted in annulation of nopinane carbon frame with pyridine and regioselective formation of chiral nopinane-annelated pyridines in 20–39% yields. Chemical structure of the pyridine derivatives were proved by precise NMR study.
We have analyzed paintings on six stone slabs from Bronze Age burial sites of the Karakol culture in the Altai, Karakol and Ozernoye. Most represent anthropomorphous figures, depicted in a mixed technique including pecking, engraving, abrasion, and painting in various combinations. Paintings are superimposed on previously made petroglyphs, which had not initially been painted.

Samples of paint were analyzed using optical microscopy, scanning electron microscopy with X-ray spectrometry, and synchrotron powdered X-ray diffraction.

Results make it possible to differentiate, using the instrumental analysis, intentional painting from natural coloration. The composition of pigments suggests that both the images and the framing lines were made with one and the same red paint. However, while the pigment composition is homogeneous in each burial, it differs between the burials. Paint was found not only on slabs but on human bones as well, with its color varying from light red to black. Further analysis will hopefully shed light on the Karakol burial rite.
We introduce a thermodynamical model of filament growing when a current pulse via memristor flows. The model is the boundary value problem, which includes nonstationary heat conduction equation with non-linear Joule heat source, Poisson equation, and Shockley- Read-Hall equations taking into account strong electron-phonon interactions in trap ionization and charge transport processes. The charge current, which defines the heating in the model, depends on the rate of the oxygen vacancy generation. The latter depends on the local temperature. The solution of the introduced problem allows one to describe the kinetics of the switch process and the final filament morphology.
To study the efficacy, safety and effect on vascular age of free-equivalent and fixed-dose combinations of amlodipine, a renin-angiotensin-aldosterone system blockers and rosuvastatin in patients with high and very high cardiovascular risk with uncontrolled hypertension and concomitant dyslipidemia.

This open-label case series study included 148 men and women (mean age 60,63±8,16 years). The patients were randomly divided into 2 groups: group 1 (n=76) received a triple fixed-dose combination of amlodipine, lisinopril, rosuvastatin; group 2 (n=72) received a dual free-equivalent antihypertensive combination (amlodipine/losartan) and rosuvastatin. The doses were selected by the attending physician and were not regulated by the researchers. The study included an assessment of blood pressure, lipid profile (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides), biochemical profile, ASCORE value, medication adherence, changes in the augmentation index (AI) at baseline and after 6 months of therapy (first and second visits, respectively). The results were considered significant at p<0,05.

After 6 months of therapy, significant intragroup differences were noted in comparison with the baseline values. In group 1, the levels of TC (p=0,002), LDL-C (p=0,001), ASCORE value (p=0,01), and vascular age (p=0,01) significantly decreased; in group 2 — TC (p=0,03), LDL-C (p=0,005). In the group of triple fixed-dose therapy, the values of AI (p=0,04), TC (p=0,012), LDL-C (p=0,024), ASCORE value (p=0,02) and vascular age (p=0,01) were significantly lower than in the free-equivalent group. The fixed-dose combination of amlodipine, lisinopril and rosuvastatin, is more effective and equally safe relative to the free-equivalent combination of amlodipine/losartan and rosuvastatin, not only in terms of effect on LDL-C and AI, but also on vascular age parameters calculated using the ASCORE scale. This can serve as an additional motivating factor for patients to receive therapy.
We formulate the higher covariant derivative regularization for N=2 supersymmetric gauge theories in N=2 harmonic superspace. This regularization is constructed by adding the N=2 supersymmetric higher derivative term to the classical action and inserting the N=2 supersymmetric Pauli--Villars determinants into the generating functional for removing one-loop divergencies. Unlike all other regularization schemes in N=2 supersymmetric quantum field theory, this regularization preserves by construction the manifest N=2 supersymmetry at all steps of calculating loop corrections to the effective action. Together with N=2 supersymmetric background field method this regularization allows to calculate quantum corrections without breaking the manifest gauge symmetry and N=2 supersymmetry. Thus, we justify the assumption about existence of a regularization preserving N=2 supersymmetry, which is a key element of the N=2 non-renormalization theorem. As a result, we give the prove of the N=2 non-renormalization theorem which does not require any additional assumptions.
This paper introduces the concept of iterant algebra and applies it to the formation of basic Clifford algebras including a reconstruction of the complex numbers in terms of a formalization of temporal process.

Iterant algebra is shown to include all of matrix algebra and applications are given to a representation of the su (3) Lie algebra for the Standard Model and to the construction of the Dirac Equation. This construction of the Dirac Equation makes it clear how solutions arise from nilpotent elements in the Clifford algebra and how Fermion algebra and the algebra of Majorana Fermions emerges in this context.

The paper ends with a formulation of the original Majorana Dirac Equation in terms of Clifford algebra in the context of iterants.