Hengzongshu/ArticleAgent huggingface dataset:
Objective: The objective is to improve non-invasive diagnostic algorithm (NDA) to identify food allergy (FA) in infants since their first months of live. Methods: We have done clinical and anamnestic examination and subsequent follow-up of 26 infants aged from 1 week old to 9 months old having admitted with complaints about colics, diarrhea, abdominal distension and skin rashes. Primary screening was performed using CoMiss tool, then anamnesis data was collected according NDA. Results: FA was diagnosed in 34.6 % of infants due to improved NDA. Case follow-up suggested the presence of FA in 46.1% of patients. Conclusions: The questionnaire showed a high clinical effectiveness and uniqueness, exceeding current alternatives for non-invasive diagnostics of malabsorption syndrome in infants.
For compact manifolds with infinite fundamental group we present sufficient topological or metric conditions ensuring the existence of two geometrically distinct closed geodesics.

We also extend results about generic Riemannian metrics to Finsler metrics. We show a bumpy metrics theorem for Finsler metrics

and prove that a $$C^4$$ C4 -generic Finsler metric on a compact and simply-connected manifold carries infinitely many closed geodesics.
The results of the studies of the mechanisms of microelements accumulation in the radon waters of the Zaeltsovsky field (the southern part of West Siberia) are presented for the first time. The key role of the water-rock system in these processes is shown.

The radon waters of calcium hydrocarbonate and calcium-sodium hydrocarbonate composition with total mineralization ranging from 322 up to 895 mg/dm3 (222Rn = 11-801 Bq/dm3) are prevailing in the field. Metal species such as Ag+, Ba2+, Zn2+, Ni2+, Mn2+, Sr2+, Fe2+ are represented by free ions, and Be2+, Fe3+, Zr4+, Ti4+ by hydroxide complexes. Calculations reveal that the waters are saturated with carbonate (modifications CaCO3 and CaMg(CO3)2, MnCO3, FeCO3, PbCO3), silicate ((Fe2+, Fe3+)2 – 3Si2O5(OH)4), hydroxide (FeOOH and MnOOH) and oxide minerals (modification SiO2, TiO2, Mn2+Mn23+O4).

Radon waters are unsaturated with some compounds of zircon, zinc, barium, molybdenum, iron, copper, strontium: ZrO2, Zn(OH)2, BaCO3, CaMoO4, FeMoO4, CuO, CuMoO4, Cu3(ÑÎ3)2(ÎÍ)2, Fe(OH)2, Cu(OH)2, SrSO4, SrCO3, 3MgO2SiO2·2H2O etc. In some samples, the observed saturation of water is relatively rare phosphate minerals (Ca10(PO4)6(OH)2, Fe3(PO4)2·8H2O, MnHPO4), chlorargyrite (AgCl) and lead molybdate (PbMoO4). The concentrations of some elements (namely Sr, Pb, Zn Mo, Be) in the radon waters of the Zaeltsovsky field are at the level of their concentrations in rocks.
The existence of a new polymorph of metacetamol together with its properties are reported for the first time.
Новосибирский государственный университетНовосибирск, Россия 3 ФЕНОМЕН «ПРОЩАЛЬНЫХ СТИХОВ» В ДЗЭНСКОЙ ТРАДИЦИИС глубокой древности на Востоке с величайшим уважением и трепетом относились к начертаниям кисти, к написанному слову, которое «и есть сам человек» (Tanchu Terayama, 2005.P.7).В неизмеримо большей степени это относится к юигэ -предсмертным строкам, обнажающим, как считалось, саму суть человека.Феномен «прощальных стихов», написанных в последние мгновения жизни, принадлежит к самым волнующим рукописным завещаниям в истории человечества.

В статье анализируются отдельные, наиболее репрезентативные, с точки зрения автора, предсмертные строки выдающихся дзэнских наставников, предпринимается попытка исследовать особенность данного феномена, продемонстрировать факт того, что эти последние «следы туши» -отнюдь не произведения искусства, и они не имеют ничего общего с эстетическим опытом.

Отсутствие в российском востоковедении исследований на эту тему обеспечивает данной работе определённую значимость и актуальность.
The Free Electron Laser (FEL) based on multi-turn microtron-recuperator is currently operating in Novosibirsk.

For successful operation of the facility, a specialized control system was developed. The software part of this system consists of a set of different program modules. For ensuring program connection between a client and server parts of the control software, the Channel Access protocol from the EPICS framework was employed.

Features and examples of using this protocol without utilizing the whole EPICS system are described in this article.
Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical practice, applications of existing diagnostic solutions based on the detection of somatic mutations or analysis of gene expression are limited by their high cost and difficulties with clinical interpretation.

The aim of our work was to develop an algorithm for the differential diagnosis of thyroid nodules on the basis of a small set of molecular markers analyzed by real-time PCR.A total of 494 preoperative FNA samples of thyroid goiters and tumors from 232 patients with known histological reports were analyzed: goiter, 105 samples (50 patients); follicular adenoma, 101 (48); follicular carcinoma, 43 (28); Hürthle cell carcinoma, 25 (11); papillary carcinoma, 121 (56); follicular variant of papillary carcinoma, 80 (32); and medullary carcinoma, 19 (12). Total nucleic acids extracted from dried FNA smears were analyzed for five somatic point mutations and two translocations typical of thyroid tumors as well as for relative concentrations of HMGA2 mRNA and 13 microRNAs and the ratio of mitochondrial to nuclear DNA by real-time PCR. A decision tree-based algorithm was built to discriminate benign and malignant tumors and to type the thyroid cancer. Leave-p-out cross-validation with five partitions was performed to estimate prediction quality. A comparison of two independent samples by quantitative traits was carried out via the Mann-Whitney U test.

A minimum set of markers was selected (levels of HMGA2 mRNA and miR-375, - 221, and -146b in combination with the mitochondrial-to-nuclear DNA ratio) and yielded highly accurate discrimination (sensitivity = 0.97; positive predictive value = 0.98) between goiters with benign tumors and malignant tumors and accurate typing of papillary, medullary, and Hürthle cell carcinomas. The results support an alternative classification of follicular tumors, which differs from the histological one.The study shows the feasibility of the preoperative differential diagnosis of thyroid nodules using a panel of several molecular markers by a simple PCR-based method. Combining markers of different types increases the accuracy of classification.
An abrupt change in internuclear Re-Re distances between {Re(6)} subunits in the carbon-centered [Re(12)mu(6)-CS(17)(CN)(6)](n-) complexes caused by the change of the oxidation state (n = 6, 8) is first theoretically shown to be possibly controlled by an external electric field. (13)C NMR signal is shown to change over ~400 ppm (~37G) for mu(6)-C atom together with n. Thereby, the metal cluster [Re(12)mu(6)-CS(17)(CN)(6)](n-) can be considered as a perspective model of a molecular switch.
The source of electrons that generates a beam of a large cross section (BLCS) with the beam release into the atmosphere through a thin metal foil has been developed in the IHCE SB RAS. The electronic BLCS in this case is a superposition of elementary beams formed by separate emission structures.

Their plasma boundary is stabilized by a fine-grained metal mesh, covered by a mask with round holes. The configuration of holes repeats the configuration of the holes in the support grid of the outlet foil window having a slightly larger diameter. In preliminary experiments, the maximum current-to-atmosphere output coefficient reached ∼70% of the current in the accelerating gap.

The objective of this paper is to select a numerical model of the electron-optical system (EOS) for computer simulation and analysis of the characteristics of the formed elementary beams for further optimization of the source and increase the efficiency of beam extraction into the atmosphere.
Using fluorescent probes, we demonstrate that the plasma membrane of porcine eye lens fiber cells displays an unprecedentedly high degree of lipid ordering.
This is the first application of FISH technique in the Auchenorrhyncha, a suborder of the Hemiptera.

A cytogenetic investigation was performed in eight species of the spittlebug genus Philaenus using silver-NOR (AgNOR)-banding and fluorescence in situ hybridization (FISH) with 18S rDNA and (TTAGG)n telomeric probes.

FISH along with the rDNA probe revealed differences between species in the number and chromosomal location of major ribosomal RNA gene sites, the so-called nucleolar organizer regions (NORs). However, we found a lack of perfect correlation between the results of AgNOR-staining and rDNA-FISH in the detection of NORs. FISH with the telomeric probe confirmed that the chromosome ends of the Philaenus species are composed of the (TTAGG)n nucleotide sequence, which is a common motif of insect telomeres.
For medical genetic counseling, estimating the chance of a child being born with chromosome abnormality is crucially important. Cytogenetic diagnostics of parents with a balanced karyotype are a special case. Such chromosome rearrangements cannot be detected with comprehensive chromosome screening.

In the current paper, we consider chromosome diagnostics in two cases of chromosome rearrangement in patients with balanced karyotype and provide the results of a detailed analysis of complex chromosomal rearrangement (CCR) involving three chromosomes and a small supernumerary marker chromosome (sSMC) in a patient with impaired reproductive function. The application of fluorescent in situ hybridization, microdissection, and multicolor banding allows for describing analyzed karyotypes in detail.

In the case of a CCR, such as the one described here, the probability of gamete formation with a karyotype, showing a balance of chromosome regions, is extremely low. Recommendation for the family in genetic counseling should take into account the obtained result. In the case of an sSMC, it is critically important to identify the original chromosome from which the sSMC has been derived, even if the euchromatin material is absent. Finally, we present our view on the optimal strategy of identifying and describing sSMCs, namely the production of a microdissectional DNA probe from the sSMC combined with a consequent reverse painting.
The authors suggest using a numerical method based upon the finite element analysis of the equations of continuous inhomogeneous media mechanics to describe thermophysical properties of transient motions of viscous gas through porous media with chemical changes and phase transitions in a solid phase.

The model takes into account heat exchange between a solid frame and gas, changes in the phase volume and mass at interaction, the presence of oxidant diffusion. The software developed in FreeFem++ allows clear and vivid studying the process of gas combustion in solid porous medium with inhomogeneous combustion source at forced filtration in the course of time

as well as modeling and analyzing a real experiment.
In a thermonuclear reactor plasma interacts with the divertor walls in the form of periodic heat pulses as well as constant heat load. As a result, residual plastic deformations and mechanical stresses can occur, which cause destruction of the divertor material. However, these residual deformations and stresses can be relieved under the influence of constant flux of plasma and the consequential high temperature of the material.

The goal of this work was the study of residual stresses dynamics in a heated material. Residual deformations and stresses were measured using X-ray diffractometry. The measurements were conducted on tungsten samples that were irradiated with an electron beam on the BETA facility with the purpose of simulating plasma heat loads. Synchrotron radiation scattering station 'Anomalous scattering' on the beam line 2 of VEPP-3 was used to measure diffractograms from which scattering angle – sample tilt angle dependencies were obtained. The experimental data was used for calculation of deformation and stress tensor components. To compare heat load and residual stress profiles the measurements were conducted with spatial resolution. Synchrotron radiation scattering station 'Diffraction movie' was used for measuring the dynamics of residual stresses during heating.

As a result of these experiments scattering angle – temperature dependencies were obtained. Residual stresses relaxation was measured, the result has met our expectations.
The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions. Groups of animals that had the same winning and losing track record followed by a no-fight period for 14 days were also studied.

Snca mRNA levels were increased in the raphe nuclei in the losers and in the VTA of the winners. After fighting deprivation Snca mRNA levels were decreased to the control level in both groups. Snca mRNA levels were similar to the control level in the VTA of the losers and in the raphe nuclei of the winners. However Snca gene expression was increased in these areas after no-fight period in the winners and losers in comparison with respective mRNA levels in the undeprived animals. Significant positive correlations were found between the mRNA levels of Snca and Bdnf genes in the raphe nuclei.

It was concluded, that social experience affects Snca gene expression depending on brain areas and functional activity of monoaminergic systems in chronically victorious or defeated mice.
photovoltaic polymer/fullerene composites

Q-Band electron spin echo spectroscopy

distinguishing light-induced polarons of different types
The development of microcollimators for photon energy in the range of 30-200 keV was carried out. A quasi-spherical or quasi-plane X-ray wave can be formed when the propagation vector of the collimator is locally parallel to the wave front, either near the X-ray focus or away from it. The method was tested to collimate the widespread beam from an X-ray generator. In the experiment, a flat nickel raster 1200 μm thick with tubes of 80 μm in diameter manufactured using LIGA technique, was used. For a flash X-ray device with an explosive electron emission and an anode voltage of 150 kV, a quasi-collimated X-ray beam with an angular divergence of up to 2.8 degrees (FWHM) was formed.
Propagation of an extraordinary electromagnetic wave in the vicinity of electron cyclotron resonance surface in an open linear trap is studied analytically, taking into account inhomogeneity of the magnetic field in paraxial approximation. Ray trajectories are derived from a reduced dispersion equation that makes it possible to avoid the difficulty associated with a transition from large propagation angles to the case of strictly longitudinal propagation.

Our approach is based on the theory, originally developed by Zvonkov and Timofeev [Sov. J. Plasma Phys. 14, 743 (1988)], who used the paraxial approximation for the magnetic field strength, but did not consider the slope of the magnetic field lines, which led to considerable error, as has been recently noted by Gospodchikov and Smolyakova [Plasma Phys. Rep. 37, 768–774 (2011)].

We have found ray trajectories in analytic form and demonstrated that the inhomogeneity of both the magnetic field strength and the field direction can qualitatively change the picture of wave propagation and significantly affect the efficiency of electron cyclotron heating of a plasma in a linear magnetic trap. Analysis of the ray trajectories has revealed a criterion for the resonance point on the axis of the trap to be an attractor for the ray trajectories. It is also shown that a family of ray trajectories can still reach the resonance point on the axis if the latter generally repels the ray trajectories. As an example, results of general theory are applied to the electron cyclotron resonance heating experiment which is under preparation on the gas dynamic trap in the Budker Institute of Nuclear Physics [Shalashov et al., Phys. Plasmas 19, 052503 (2012)].
During the research seismogeological models of the Neoproterozoic-Phanerozoic sedimentary complexes of the Siberian Platform (Anabar-Khatanga and Lena-Anabar oil and gas regions) northern part were constructed. It is concluded that in the Anabar-Khatanga and Lena-Anabar oil-and-gas areas Permian anticlinal traps complexly related to the salt diapirs have the best prospects of petroleum production. The carbonate deposits of Riphean-Carbon are also of interest. The existing geological and geophysical materials do not allow precisely stratify the Laptev Sea basin sedimentary cover. The thickness of platform deposits in which reaches 14-15 kilometers. From the structural-tectonic and general-scientific positions, this sedimentary basin is located in favorable conditions for the formation of hydrocarbon fields.
We propose a high-resolution optical time domain reflectometry (OTDR) based on an all-fiber supercontinuum source. The source simply consists of a laser with moderate power and a section of fiber which has a zero dispersion wavelength near the laser's central wavelength. Spectrum and time domain properties of the source are investigated, showing that the source has great capability in nonlinear optics, such as correlation OTDR. We analyze one of the key factors limiting the operational range of such an OTDR, i.e., sampling time. Finally, we experimentally demonstrate a correlation OTDR with 25km sensing range and 5.3cm spatial resolution, as a verification of theoretical analysis.
Background. The problem of studying the development of stroke in men of working age working in conditions of high professional risk is relevant.

Materials and methods. The study included 111 men aged 30 to 65 years who worked for 5 or more years in the following professions: electric gas welder, gas welder, smelter. The study participants were divided into two groups: the first group – 45 men who had a stroke; the second group – 66 men who did not have stroke history. The subjects of both groups were comparable in terms of occupational structure, age and length of service. Using the method of sequential inclusion of the studied risk factors for stroke development (Forward Stepwise), we determined those that made a significant contribution to the possible development of stroke.

Results. Based on multivariate analysis, a logistic regression formula was derived that determines the likelihood of a stroke in patients working under the influence of the toxic dust factor, which included the following factors: the presence of dyslipidemia factor (β-coefficient = 3.7; p = 0.001), the patient’s diagnosis is “stage III arterial hypertension” (β-factor = 5.6; p = 0.002), blood pressure control (β-factor = –3.4; p = 0.005). The patient determines the value of these three parameters, substitutes the appropriate formula for calculating the value of p(X). A value of p(X) in excess of 0.5 indicates a high risk of stroke in men working under conditions of exposure to toxic dust factors. The sensitivity of the proposed method was 84.4 %, specificity – 92.4 %. Conclusion. The multivariate model is informative for the individual prediction of the development of stroke in men working under the influence of the toxic-dust factor, since it reflects the degree of influence of one or another factor on the development of the disease.
Serpentinization is an important post-magmatic process in spreading and subducted zones. This process is the cause of the remobilization and redistribution of highly mobile elements, platinum group elements (PGE) and base metals. Secondary platinum group minerals (PGMs) formed because of PGE remobilization under the action of mantle and crustal fluid on the rocks. The formation of the secondary PGMs can occur in several stages. Under the effect on the chromitites of reduced mantle fluids, native PGE alloys were formed during early serpentinization. Under dehydrating subducted slab fluid phase was caused in serpentinization mantle peridotites and have been dissolved magmatic high-temperature platinum group minerals. During the obduction of ophiolites, an inversion from reducing to oxidizing condition took place with the formation of nickel arsenides and As, Sb – bearing PGMs.
Each year about 400 000 people in Russia get strokes. Whereas an acute treatment takes place in specialized intensive care units in hospitals, follow-up is handed over to general (rarely – private) practitioner. The majority of stroke survivors show low adherence to follow-up resulting in repeated hospitalizations and growth of multi-morbidity burden.

With COVID-19 pandemic negatively affecting availability of medical services and increasing health risks for stroke survivors, a physician-patient relation becomes the means of persuading patients to healthpromoting behaviour.
In this species, only polydactyly types with medial accessory toes have been described and are usually inherited as a dominant trait with incomplete penetrance.

A visual survey of the livestock was conducted, and a description of the detected anomaly was compiled. Anatomical and morphological analyses showed that the lateral extra digit is an anatomically complete structure. Cytological examination revealed no specific karyotypic features. Genealogical analysis and results of crosses are consistent with a working hypothesis of recessive inheritance of the trait.

Overall, the study shows that this type of polydactyly is anatomically and morphologically unique and not typical of Sus scrofa. In our case, the results of test crosses indicate recessive inheritance of the trait with varying expression and incomplete penetrance.
Procedures relying on infinitesimals in Leibniz, Euler and Cauchy have been interpreted in both a Weierstrassian and Robinson's frameworks. The latter provides closer proxies for the procedures of the classical masters. Thus, Leibniz's distinction between assignable and inassignable numbers finds a proxy in the distinction between standard and nonstandard numbers in Robinson's framework, while Leibniz's law of homogeneity with the implied notion of equality up to negligible terms finds a mathematical formalisation in terms of standard part. It is hard to provide parallel formalisations in a Weierstrassian framework but scholars since Ishiguro have engaged in a quest for ghosts of departed quantifiers to provide a Weierstrassian account for Leibniz's infinitesimals.

Euler similarly had notions of equality up to negligible terms, of which he distinguished two types: geometric and arithmetic. Euler routinely used product decompositions into a specific infinite number of factors, and used the binomial formula with an infinite exponent. Such procedures have immediate hyperfinite analogues in Robinson's framework, while in a Weierstrassian framework they can only be reinterpreted by means of paraphrases departing significantly from Euler's own presentation. Cauchy gives lucid definitions of continuity in terms of infinitesimals that find ready formalisations in Robinson's framework but scholars working in a Weierstrassian framework bend over backwards either to claim that Cauchy was vague or to engage in a quest for ghosts of departed quantifiers in his work.

Cauchy's procedures in the context of his 1853 sum theorem (for series of continuous functions) are more readily understood from the viewpoint of Robinson's framework, where one can exploit tools such as the pointwise definition of the concept of uniform convergence.