Hengzongshu/ArticleAgent huggingface dataset:
The myelodysplastic syndrome (MDS) holds a special place among blood cancers, as it represents a whole spectrum of hematological disorders with impaired differentiation of hematopoietic precursors, bone marrow dysplasia, genetic instability and is noted for an increased risk of acute myeloid leukemia. Both genetic and epigenetic factors, including microRNAs (miRNAs), are involved in MDS development. MicroRNAs are short non-coding RNAs that are important regulators of normal hematopoiesis, and abnormal changes in their expression levels can contribute to hematological tumor development.

To assess the prognosis of the disease, an international assessment system taking into account a karyotype, the number of blast cells, and the degree of deficiency of different blood cell types is used.

However, the overall survival and effectiveness of the therapy offered are not always consistent with predictions. The search for new biomarkers, followed by their integration into the existing prognostic system, will allow for personalized treatment to be performed with more precision. Additionally, this paper explains how miRNA expression levels correlate with the prognosis of overall survival and response to the therapy offered.
We report on the first search for electron-muon lepton flavor violation (LFV) in the decay of a b quark and b antiquark bound state. We look for the LFV decay ϒ(3S)→e^{±}μ^{∓} in a sample of 118 million ϒ(3S) mesons from 27 fb^{-1} of data collected with the BABAR detector at the SLAC PEP-II e^{+}e^{-} collider operating with a 10.36 GeV center-of-mass energy. No evidence for a signal is found, and we set a limit on the branching fraction B[ϒ(3S)→e^{±}μ^{∓}]80 TeV on the energy scale Λ_{NP} divided by the coupling-squared g_{NP}^{2} of relevant new physics (NP).
The thermophilic strain of the genus Geobacillus, Geobacillus icigianus is a promising bacterial chassis for a wide range of biotechnological applications. In this study, we explored the metabolic potential of Geobacillus icigianus for the production of 2,3-butanediol (2,3-BTD), one of the cost-effective commodity chemicals. Here we present a genome-scale metabolic model iMK1321 for Geobacillus icigianus constructed using an auto-generating pipeline with consequent thorough manual curation. The model contains 1321 genes and includes 1676 reactions and 1589 metabolites, representing the most-complete and publicly available model of the genus Geobacillus. The developed model provides new insights into thermophilic bacterial metabolism and highlights new strategies for biotechnological applications of the strain. Our analysis suggests that Geobacillus icigianus has a potential for 2,3-butanediol production from a variety of utilized carbon sources, including glycerine, a common byproduct of biofuel production. We identified a set of solutions for enhancing 2,3-BTD production, including cultivation under anaerobic or microaerophilic conditions and decreasing the TCA flux to succinate via reducing citrate synthase activity. Both in silico predicted metabolic alternatives have been previously experimentally verified for closely related strains including the genus Bacillus.
This paper provides results of measuring the conductivity of explosives pentaerythritol tetranitrate and trinitrotoluene composites containing single-walled carbon nanotubes.

The conductivity depends on the applied voltage nonlineary and irreversibly changes under the influence of current loads about several amperes for milliseconds.
Ghrelin, a peptide hormone mostly produced by stomach, plays an important role in regulation of feeding behavior, energy balance and glucose homeostasis.to determine the relationships between fasting serum levels of ghrelin, body composition, adipose tissue endocrine function and glucose variability (GV) in type 2 diabetic subjects with and without obesity.We observed 124 individuals with type 2 diabetes, including 42 non - obese subjects and 82 patients with obesity. Thirty non - obese healthy subjects were acted as control. The concentrations of ghrelin, leptin, resistin, and visfatin in the fasting serum were determined by Multiplex analysis. Body composition was assessed with DEXA. The 24-hour and nocturnal GV parameters were derived from continuous glucose monitoring.Ghrelin levels in patients with diabetes were decreased significantly as compared to control (p.Грелин - пептидный гормон, продуцируемый главным образом в желудке, играет важную роль в регуляции пищевого поведения, энергетического баланса и гомеостаза глюкозы. Цель исследования. Определить взаимосвязи между уровнем грелина в сыворотке крови натощак, композитным составом тела, эндокринной функцией жировой ткани и параметрами вариабельности гликемии (ВГ) у больных сахарным диабетом (СД) 2-го типа с наличием и отсутствием ожирения. Материалы и методы. Обследовано 124 пациента с СД 2-го типа, в том числе 42 без ожирения и 82 с ожирением. Контролем являлись 30 здоровых лиц без ожирения. Концентрации грелина, лептина, резистина, висфатина в сыворотке крови натощак определяли с помощью мультиплексного анализа. Композитный состав тела исследовали с помощью двухэнергетической рентгеновской абсорбциометрии. Суточные и ночные параметры ВГ рассчитывали по данным непрерывного мониторинга уровня глюкозы. Результаты и обсуждение. Уровень грелина у больных СД оказался достоверно ниже в сравнении с контролем (p.
A haplogroup is a group of similar alleles that have a common ancestor in which a mutation has occurred, inherited by all descendants. Haplogroups, particularly from the Y-chromosome (Y-DNA), is widely used in population genetics and genetic genealogy, a science that studies the genetic history of mankind. Recent studies of the Y-chromosome of modern Kazakhs have demonstrated the diversity of the Kazakh gene pool.

During the expedition carried out in 2014-2016, clinical material was collected from various regions of Kazakhstan, representing samples of peripheral blood and buccal scrapings. All representatives of Kazakh nationality were familiarized with informed consent. In total 1623 respondents participated in the study, 169 of whom were representatives from Baiuly tribe of Junior zhuz.

We analyzed the provided samples and found that the Baiuly is characterized by 10 haplogroups, the most prevailing of which is the C2 haplogroup (85%).
In this survey, we formulate the Gröbner-Shirshov bases theory for associative algebras and Lie algebras.

Some new Composition-Diamond lemmas and applications are mentioned.
Non-heme iron(II) complexes are widespread synthetic enzyme models, capable of conducting selective C–H oxidation with H2O2 in the presence of carboxylic acid additives. In the last years, structurally similar manganese(II) complexes have been shown to catalyze C–H oxidation with similarly high selectivity, and with much higher efficiency. In this mini-review, recent catalytic and mechanistic data on the selective C–H oxygenations with H2O2 in the presence of manganese complexes are overviewed. A distinctive feature of catalyst systems of the type Mn complex/H2O2/carboxylic is the existence of two alternative reaction pathways (as found for the oxidation of cumenes), one leading to the formation of alcohol, and the other to ester. The mechanisms of formation of the alcohol and the ester are briefly discussed.
Most photoswitchable molecular magnets exhibit thermally induced switching, as is typical of spin crossover (SCO), valence tautomerism and SCO-like phenomena. We report a rare case of a copper-nitroxide based molecular magnet Cu(hfac)2Li-Pr that does not exhibit quantitative SCO-like behavior in the temperature range of its chemical stability (2–350 K); however, it can be switched to a metastable thermally inaccessible spin state via visible/near-IR light at cryogenic temperatures. By means of photogeneration, unique information on this otherwise unobservable spin state has been obtained using steady-state Q-band (34 GHz) and time-resolved W-band (94 GHz) electron paramagnetic resonance (EPR) spectroscopy. In particular, we have found that the electronic structure and relaxation properties of the photoinduced state in Cu(hfac)2Li-Pr are very similar to those in its sister compound Cu(hfac)2Ln-Pr that is thermally switchable and has been exhaustively characterized by many analytical methods, previously. The first observation of photoswitchable behavior in a thermally unswitchable copper-nitroxide based molecular magnet Cu(hfac)2Li-Pr paves the way for photoswitching applications of this and similar compounds in the remarkably broad temperature range of 2–350 K.
The biostability of the polyurethanes Tecoflex EG-80A and Pellethane 2363-80A, used as basic polymers of the vascular grafts (VGs) produced by electrospinning, as well as the tensile strength of Tecoflex VGs, are studied. Solutions of Tecoflex or Pellethane with gelatin and bivalirudin in 1,1,1,3,3,3-hexafluoroisopropanol are used for VG production. After 1, 12, and 24 weeks of VG implantation in the infrarenal position of the abdominal aorta of Wistar rats, VGs are explanted, fixed in formalin, freed from outer tissues, dialyzed, and dried. The polyurethanes are extracted from VGs by dispersion/extraction in tetrahydrofuran (THF) and freed from the excess of THF-insoluble biopolymers. The stability of polyurethanes is assessed by IR spectroscopy and gel permeation chromatography. Pellethane has emerged to be stable at all experimental points. Tecoflex loses approximately 10% of its molecular weight (both Mn and Mw) after 3 months and restored its initial value within 6 months of its functioning as a graft. Mechanical testing demonstrates a 30% reduction in the tensile strength after 3 months in VG and a 10% increase after 6 months. The stability and mechanical properties of polyurethane-based VGs demonstrate their utility for the reconstitution of damaged arteries.
The aim of this work was to develop a method of panoramic optical diagnostics of the inhomogeneity of the density field in stratified flows based on the registration of the distribution of the Rayleigh scattering intensity using structured laser radiation. Several approaches have been implemented for organizing spatial modulation of laser illumination, intended for use with various values of the incident radiation energy density. To test the processing and reconstruction algorithms of the experimental data, a series of measurements was carried out using the method of planar laser-induced fluorescence. The distribution of local density in a jet of carbon dioxide flowing into atmospheric air was measured experimentally using a method based on the registration of Rayleigh scattering.
Disease resistance is an important characteristic for each variety of potato, and the search for pathogen resistance markers is one of the primary tasks of plant breeding. Higher plants possess a wide spectrum of enzymes catalyzing the hydrolysis of nucleic acids; it is believed that protection against pathogens is the most probable function of the enzymes. RNases are actively involved in several immune systems of higher plants, for example, systemic acquired resistance (SAR) and genetic silencing, hence RNase activity in plant leaves, as a relatively easily measured parameter, can serve as a good marker for the selection of pathogen resistant varieties. We have analyzed sixteen varieties of potatoes permitted for use on the territory of the Russian Federation and tested the correlation of the level of variety­specifc ribonuclease (RNase) activity with such economically valuable traits as maturity and resistance to viruses, late blight and common scab. In general, the level of RNase activity was variety­specifc, which was confrmed by very small values of average squared error for the majority of tested varieties. We have detected a statistically signifcant positive correlation of RNase activity in potato leaves with increased resistance of varieties to phytopathogenic viruses, a negative correlation with resistance to scab and an absence of a signifcant connection with maturity and resistance to late blight, regardless of the organ affected by the oomycete. Thus, the level of RNase activity in potato leaves can be used as a selective marker for resistance to viruses, while varieties with increased RNase activity should be avoided when selecting resistance to scab.
The work is devoted to the development of an application for monitoring and controlling the state of equipment (extruder) for the petrochemical industry based on sensor readings using a machine learning model. The statistical relationships of the technological process parameters are analyzed, the most significant parameters influencing the occurrence of failures are determined using SHAP values. The hypotheses regarding the effectiveness of various machine learning algorithms in relation to the real problem of predicting the technical state of the extruder are tested. A gradient boosting model has been developed to predict the probability of extruder shutdown due to the formation of polypropylene agglomerates. The developed application allows interpreting the results of the model, which makes it possible to select the most important process parameters that have the greatest impact on the probability of extruder failure, and also proposing a prototype of an extruder monitoring system based on sensor readings using a machine learning model.
Pursuing the goal to single out the validity region of the high-energy resummation, better known as BFKL approach, and to possibly disentangle BFKL effects from the ones coming from a DGLAP-inspired, fixed-order description

new predictions for the forward inclusive hadron-jet production, tailored on the CMS and CASTOR acceptances, are given
МОРФОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА РЕАКЦИЙ МЯГКИХ ТКАНЕЙ ПРИ ИМПЛАНТАЦИИ ТИТАНОВЫХ ИМПЛАНТАТОВ ДЛЯ КРАНИОПЛАСТИКИ

ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ

Мишинов С.В. 1 , Копорушко Н.А. 1 , Ларионов П.М. 2 , Мухамадияров Р
<p>Residents of monotowns face a specific range of problems affecting their social well-being. The purpose of the study was to identify and describe the types of life strategies of monotown residents with a focus on the place of residence and the location of the attractiveness of the urban environment and migration attitudes in them. The study employed a case-study strategy of an in-depth interview with residents of Sayansk, a monotown that displays risks of socio-economic deterioration. To describe the context, the authors used statistical data on the population and migration of the Sayansk population, as well as historical chronicle of the town. Based on two indications (perception of the quality of the urban environment and the migration attitudes), the authors have constructed a typology of life strategies and described the related characteristics of inhabitants. The study shows that the life strategies of the inhabitants reveal, on the one hand, a spectrum of migration patterns (depending on the characteristics of the inhabitants), and, on the other hand, various degrees of satisfaction with the quality of the urban environment, which makes the city attractive or unattractive in the eyes of the population.</p>
Dynamic nuclear polarization (DNP), a technique that significantly enhances NMR signals, is experiencing a renaissance owing to enormous methodological developments. In the heart of DNP is a polarization transfer mechanism that endows nuclei with much larger electronic spin polarization. Polarization transfer via the Overhauser effect (OE) is traditionally known to be operative only in liquids and conducting solids. Very recently, surprisingly strong OE-DNP in insulating solids has been reported, with a DNP efficiency that increases with the magnetic field strength.

Here we offer an explanation for these perplexing observations using a combination of molecular dynamics and spin dynamics simulations.

Our approach elucidates the underlying molecular stochastic motion, provides cross-relaxation rates, explains the observed sign of the NMR enhancement, and estimates the role of nuclear spin diffusion. The presented theoretical description opens the door for rational design of novel polarizing agents for OE-DNP in insulating solids.
Intrinsically disordered proteins play a central role in dynamic regulatory and assembly processes in the cell. Recently, a human κ-casein proteolytic fragment called lactaptin (8.6 kDa) was found to induce apoptosis of human breast adenocarcinoma MCF-7 and MDA-MB-231 cells with no cytotoxic activity toward normal cells. Earlier, we had designed some recombinant analogs of lactaptin and compared their biological activity. Among these analogs, RL2 has the highest antitumor activity, but the amino acid residues and secondary structures that are responsible for RL2's activity remain unclear.

To elucidate the structure-activity relations of RL2, we studied the structural and aggregation features of this fairly large intrinsically disordered fragment of human milk κ-casein by a combination of physicochemical methods: NMR, paramagnetic relaxation enhancement (PRE), Electron Paramagnetic Resonance (EPR), circular dichroism, dynamic light scattering, atomic force microscopy, and a cytotoxic activity assay.

It was found that in solution, RL2 exists as stand-alone monomeric particles and large aggregates. Whereas the disulfide-bonded homodimer turned out to be more prone to assembly into large aggregates, the monomer predominantly forms single particles. NMR relaxation analysis of spin-labeled RL2 showed that the RL2 N-terminal region, which is essential not only for multimerization of the peptide but also for its proapoptotic action on cancer cells, is more ordered than its C-terminal counterpart and contains a site with a propensity for α-helical secondary structure.
This study presents new whole rock major and trace element, Sr-Nd isotopic, petrographic, and geochronologic data for seven latest Permian (Changhsingian)–Late Triassic (Carnian) granitoid intrusions of the northwestern and northeastern Taimyr Peninsula in the Russian High Arctic. U-Pb zircon ages, obtained using secondary ion mass spectrometry (SIMS), sensitive high-resolution ion microprobe (SHRIMP), and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), define the crystallization age of the Taimyr intrusions studied as ranging from ca. 253 Ma to 228 Ma, which suggests two magmatic pulses of latest Permian–Early Triassic and Middle–Late Triassic age. Ar-Ar dating of biotite and amphibole indicate rapid cooling of the intrusions studied, but Ar-Ar ages of several samples were reset by secondary heating and hydrothermal activity induced by the Middle–Late Triassic magmatic pulse. Petrographic data distinguish two groups of granites: syenite–monzonites and granites–granodiorites. Sr-Nd isotopic data, obtained from the same intrusions, show a variation of initial (87Sr/86Sr)i ratios between 0.70377 and 0.70607, and εNd(t) values range between –6.9 and 1.2. We propose that the geochemical and isotopic compositions of the Late Permian–Triassic Taimyr granites record the existence of a magma mush zone that was generated by the two pulses of Siberian Traps large igneous province (LIP) magmatism.
Aim. To study the diagnostic significance of genetic testing in patients with dilated cardiomyopathy (DCM), identify predictors of life-threatening ventricular tachyarrhythmias (VTAs) and assess adverse clinical outcomes in different genetic groups. Material and methods. The study included 126 unrelated patients with verified DCM as follows: 70 (55,6%) probands with criteria for familial DCM and 56 (44,4%) individuals with a probable hereditary component. All patients (age, 43,1±11,3 years; men, 92 (73%); left ventricular ejection fraction, 30,6±8,43%; left ventricular enddiastolic diameter, 68,3±8,36 mm; follow-up period — median, 49 months) receive a complex of diagnostic investigations, including genetic screening using nextgeneration sequencing, followed by verification of variants by the Sanger method. Results. Pathogenic and likely pathogenic genetic variants were found in 61 (48,4%) of 126 patients with DCM. The dominant mutations were titin-truncating variants ( TTNtv s), identified in 16 individuals (12,7%), and variants of lamin A/C ( LMNA ), identified in 13 probands (10,3%). Mutations in the other 19 genes were found in 32 (25,4%) patients. The following primary endpoints were assessed: sudden cardiac death (SCD), episodes of VTA (sustained ventricular tachycardia/ventricular fibrillation) and appropriate shocks of implanted cardiac resynchronization therapy (CRT)/cardioverter defibrillators (CVD) devices. As a result of ROC analysis, the following independent risk factors for SCD were identified: mutations in the LMNA gene (AUC, 0,760; p=0,0001) and non-sustained ventricular tachycardia (cut-off heart rate ≥161 bpm: AUC, 0,788; p=0,0001). When comparing the phenotypes and genotypes of DCM, TTNtv genotype was associated with a lower prevalence of complete left bundle branch block (χ 2 =7,46; p=0,024), a lower need for CRT/CVD implantation (χ 2 =5,70; p=0,017) and more rare episodes of sustained ventricular tachycardia/ventricular fibrillation (χ 2 =30,1; p=0,0001) compared with LMNA carriers. Kaplan-Meier analysis showed the worst prognosis in carriers of LMNA mutations both in relation to life-threatening VTA (log rang χ 2 =88,5; p=0,0001) and in achieving all unfavorable outcomes (χ 2 =27,8; p=0,0001) compared with groups of genenegative individuals, carriers of TTNtv and other genotypes. Conclusion. The phenotypes of DCM with TTNtv did not significantly differ in the incidence of VTAs and adverse outcomes compared with the gene-negative group and other genotypes (with the exception of LMNA ). The contribution of the associations of LMNA mutations with VTAs on prognosis was confirmed, which shows the important role of LMNA genotype diagnosis for SCD risk stratification in patients with DCM.
The available hydrogeochemical data collected over the past four decades in Siberian Arctic areas were analyzed and interpreted comprehensively for the first time, through data ranking, evaluation and analysis, systematic estimation of region, altitude background and abnormal value, and calculation of element molar ratio, different kinds of correlation coefficients in water proximity were estimated. Paleohygdrogeological reconstructions of the Siberian sedimentary basins suggest the presence of three water genetic types in petroleum deposits: (1) Waters that formed during marine sedimentation, (2) Waters of meteoric origin that infiltrated the basin and were involved in supergene processes in the geological past, (3) Waters produced by condensation from a hydrocarbon mixture. Hydrogeochemical patterns of petroleum deposits are controlled by the long geological evolution in the water-rock-gas-organic matter system. Sodium-chloride bicarbonate, sodium chloride, calcium chloride groundwaters, and other types of brines with the total salinity of 0.2-350 g/L are distributed in the Siberian Arctic sedimentary basins. Comparative analysis of groundwaters and brines in the Siberian Arctic revealed a group of sodium chloride water samples had a total salinity of over 250 g/L, suggesting the formation of the brine was related to leaching of evaporite rock. Hydrogeochemical data indicate that composition of the brine has varied dramatically with their evolution. Mesozoic groundwaters and brines of Anabar-Laptev basin and West Siberia existed only in the beginning of their chemical evolution.
Primordial stellar-mass black holes, which may contribute to dark matter and to the observed LIGO binary black hole coalescences, are expected to be born with very low spins. Here we show that accretion mass gain by the components of a primordial black hole binary from the surrounding matter could lead to noticeable spins of the components prior to the coalescence provided high initial orbital eccentricities.