Hengzongshu/ArticleAgent huggingface dataset:
One of the most effective methods for gene-based mapping employs functional data analysis, which smoothes data using standard basis functions. The full functional linear model includes a functional representation of genotypes and their effects, while the beta-smooth only model smoothes the genotype effects only. Benefits and limitations of the beta-smooth only model should be studied before using it in practice. Here we analytically compare the full and beta-smooth only models under various scenarios. We show that when the full model employs two sets of basis functions equal in type and number, genotypes smoothing is eliminated from the model and it becomes analytically equivalent to the beta-smooth only model. If the basis functions differ only in type, genotypes smoothing is also eliminated from the full model, but the type of basis functions used for smoothing genotype effects becomes redefined. This leads to misinterpretation of the results and may reduce statistical power. When basis functions differ in number, no analytical comparison of the full and beta-smooth only models is possible. However, we show that the numbers of basis functions set unequal can become equal during the analysis and the full model becomes disadvantageous.
Изучена диффузия атомов индия в пленках SiO2, предварительно имплантированных ионами мышьяка с разной энергией, в зависимости от температуры последующего отжига.

Установлено, что диффузионные свойства индия зависят от присутствия в пленке атомов мышьяка и их энергии. Увеличение концентрации мышьяка в области средних пробегов ионов In+ предотвращает диффузию индия к поверхности SiO2 при высоких температурах отжига и стимулирует диффузию In вглубь в форме одновалентного междоузлия.

Обнаруженные эффекты объяснены с точки зрения формирования пар In-As в соседних замещающих положениях в матрице SiO2.
Many models of physics beyond the Standard Model predict the existence of new Abelian forces with new gauge bosons mediating interactions between "dark sectors" and the Standard Model. We report a search for a dark boson Z' coupling only to the second and third generations of leptons in the reaction e+e- -> mu+mu- Z', Z' -> mu+mu- using 514 fb-1 of data collected by the BABAR experiment. No significant signal is observed for Z' masses in the range 0.212 - 10 GeV. Limits on the coupling parameter g' as low as 7x10^-4 are derived, leading to improvements in the bounds compared to those previously derived from neutrino experiments.
The influence of extension of the aromatic core of phthalocyanines derivatives on the properties of the functionalized single walled carbon nanotubes (CNT) is studied.

For this purpose the comparative study of the structural features and sensing properties of the CNT functionalized with zinc 2,9,16,23-tetra-tert-butylphthalocyanine (ZnPc) and zinc 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine complex (ZnNc) is carried out. The adsorption of ZnPc and ZnNc molecules onto the CNT surface has been confirmed by Raman spectroscopy, SEM, and thermogravimetric analysis. It was determined that the number of ZnNc molecules anchored on the CNT walls is more than the number of ZnPc molecules. The more preferable π-π interaction of ZnNc molecules with CNT appears to be due to the bigger number of π-electrons forming naphthalocyanine aromatic system. Thin films of pristine CNT, CNT/ZnPc and CNT/ZnNc hybrids were prepared by drop casting onto interdigitated electrodes and applied as active layers to detect ammonia vapour (10-50 ppm) by measuring electrical resistance changes.

It has been shown that sensor response of the CNT/ ZnNc hybrid toward ammonia vapours is lager than that of CNT/ZnPc hybrid.
Agriculture in the Russian Federation is fundamental to the country's economic performance, living standards, the wellbeing of people and state safety. Considerations relating to food security, prospects of and challenges before plant breeding in the Siberian Federal District (SFD), the largest agricultural area of the Russian Federation, are provided in the article. The agricultural area used in the SFD is about 50 million hectares and accounts for 13 % of the country's gross grain production.

The need for the introduction of modern molecular biological methods, bioengineering and IT technology is demonstrated and discussed. As Russia as a whole, Siberia is largely engaged in unpromising extensive farming practices, which rely on natural soil fertility, and this factor should be taken into account. Another issue is noncompliance with intensive farming technologies used for cultivating new-generation commercial cultivars.

Although capital investments in plant breeding are the most cost effective investments in crop production, breeders' efforts remain underfunded. The article explains the need for fundamental reform in this economic sector: the recognition of plant breeding as being a fundamental science; a fair increase in its funding; the development of a breeding strategy, nationally and regionally; the further expansion of the network of the Breeding Centers; the re-establishment and improvement of the universities' departments specialized in plant breeding and seed production; having more state-funded places in the universities for training plant breeders to be able to maintain and cement the country's advanced position in plant breeding and to develop new globally competitive next-generation cultivars of main crops. Should these issues be ignored, all the problems that have accumulated to date will lead to risks of long-term instability in this economic sector. The need for the careful preservation of continuity in plant breeders and plants being bred is stated. The regulatory functions of the state and agricultural science in plant breeding, plant industry and seed production are considered.
Topological insulators (TIs) represent a novel quantum state of matter, characterized by edge or surface-states, showing up on the topological character of the bulk wave functions. Allowing electrons to move along their surface, but not through their inside, they emerged as an intriguing material platform for the exploration of exotic physical phenomena, somehow resembling the graphene Dirac-cone physics, as well as for exciting applications in optoelectronics, spintronics, nanoscience, low-power electronics, and quantum computing. Investigation of topological surface states (TSS) is conventionally hindered by the fact that in most of experimental conditions the TSS properties are mixed up with those of bulk-states.

Here, we devise a novel tool to unveil TSS and to probe related plasmonic effects. By engineering Bi2Te(3-x)Sex stoichiometry, and by gating the surface of nanoscale field-effect-transistors, exploiting thin flakes of Bi2Te2.2Se0.8 or Bi2Se3, we provide the first demonstration of room-temperature Terahertz (THz) detection mediated by over-damped plasma-wave oscillations on the 'activated' TSS of a Bi2Te2.2Se0.8 flake.

The reported detection performances allow a realistic exploitation of TSS for large-area, fast imaging, promising superb impacts on THz photonics.
Composite material with high thermal conductivity was obtained by the method of thermal sintering of a diamond (50 – 75%) with a size of 20 to 250 μm in a matrix of copper.

Coefficient of thermal conductivity of copper diamond composite materials was measured and is 450 – 650 W·m-1·K-1. The coefficient of thermal expansion CTE was measured and is 5.5 – 7.5 · 10-6/°C. The obtained copper diamond composite materials are promising objects for use in THz and microwave devices.
Experiments with the CMD-3 detector at the electron-positron collider VEPP-2000 started in 2010. CMD-3 is a general purpose detector designed to study e+e− annihilation into hadrons in the center-of-mass (c.m.) energy range from 0.3 up to2 GeV. The cross section of the process e+e− → K+ K−π+π− has been measured using 23 pb−1 of integrated luminosity collected in the c.m. energy range 1.5 – 2.0 GeV.
Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS.
The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used.

To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects.

Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.
The master’s degree program is the third level of higher professional education and is available after obtaining a bachelor’s or specialist’s degree. It provides an opportunity to gain deeper knowledge in a specific field and can be useful for a successful career in many areas of activity, as well as opens the way to scientific and teaching activities. Awareness of the importance of obtaining a master’s degree by a University graduate largely depends on their expectations about possible career growth and the level of future income.

The article considers the impact of master’s education on the salary level for the period from 2014 to 2018, and calculates a quantitative a priori assessment of this impact, taking into account certain factors such as the federal district of residence, age, etc. The study was based on data from the Russian monitoring of the economic situation and health of the population of the HSE - RLMS for the period 2014-2018.

It showed that successful completion of a master’s degree directly affects the level of wages. Also, the master’s program has a small but positive time effect and has the greatest impact on wages in technologically and socially developed Federal districts. The main contribution of the work to the knowledge of the subject of research was a comprehensive study of the position of master’s education, as well as determining its impact on wages, with the calculation of a quantitative a priori assessment in various simulated situations.
Industrial applications use surfactants to control surface tension and wettability of surfaces. Instead of studying prepared solutions, we focus on the movement of the contact line after adding the surfactant. We placed the pedant drop with surfactant to a sessile drop of pure water and filmed the spreading process to obtain friction coefficient of the contact line. Our results confirmed that adding surfactants to sessile droplets drives the contact line movement. Small concentrations of LHS and SDBS as well as high concentrations of SDBS pin droplet and increase the hysteresis. Friction coefficient for cationic CTAB and zwitterionic LHS drops with the concentration increase. Anionic SDBS decreases contact angle, making the surface more hydrophilic and intensifying hysteresis.
During the course of chronic viral infections or tumor growth, due to the constant presence of antigen and inflammation, a dysfunctional state of T-cells called exhaustion occurs. Factors associated with T-cell exhaustion include an increase in the expression of various inhibitory receptors, also known as checkpoint molecules, which leads to inhibition of the proliferation and production of mediators such as IL-2, IFNγ, and TNFα. The TIM-3 molecule is expressed on a variety of immune cells, including dendritic cells, macrophages, and T-cells, and mediates suppressive activity on immune cells. Sustained expression of the PD-1 receptor on T-lymphocytes is also associated with the exhaustion phenotype, while it remains unclear how the expression of these inhibitory receptors normally differs from that in pathological conditions of the body, which are characterized by an increase in the number of exhausted T-cells.

The aim of the study was to determine the relative and absolute number of T-cells expressing PD-1 and TIM-3, as well as the number of PD-1 and TIM-3 molecules on the surface of CD4 + and CD8 + T-cells in healthy donors and breast cancer (BC) patients. Group of BC patients were conditionally divided into two groups depending on the degree of disease progression into patients with primary (without metastases) and metastatic BC.

As a result of the study, it was shown that an increase in the absolute number of PD-1 + CD4 + T-cells is observed in breast cancer patients. The absolute number of molecules per cell is also higher in BC patients compared to healthy donors. For patients, a tendency towards an increase in the absolute number of TIM-3 + CD4 + T-cells was shown in comparison with healthy donors and in a row from primary disease to metastatic BC. Thus, differences in the expression pattern of TIM-3 and PD-1 checkpoint molecules are observed when comparing the norm and malignant pathology of the breast, and can become an important marker of the functional state of T-lymphocytes in BC patients.
With time education becomes more personified.New categories of learners join in educational processes and new areas of education appear.Brain-computer interfaces have good perspective to contribute to these tendencies.This technology may allow disabled people to participate in social life, including education, and may let healthy people to develop the skill of controlling brain waves.

Training the skill is the object of investigation and researchers recommend taking into account human factors: general principles of learning, motivations, personal patterns and abilities (among them, spatial).Education may be a source of highly motivated training tasks.The paper treats brain-computer interface as a type of communication and argues for semiotic training that is a variant of training spatial abilities.

Semiotic training have proved effectiveness in other areas of education.Theoretical background and preliminary empirical comments of the approach are considered.
We describe generalized running key ciphers and apply them for analysis of two Shannon's methods.

In particular, we suggest some estimation of the cipher equivocation and the probability of correct deciphering without key.
Under the III screening of the WHO MONICA-psychosocial program, a random representative sample of a population of both sexes aged of 25–64 years in Novosibirsk was examined in 1994 (n = 1346, 48.8% males; mean age 44.9 ± 0.4 years, response rate - 77.3%). The screening program performed in frame budgetary issue # AAAA-A17-117112850280-2.

It's included: registration of socio-demographic data, determination of stress at work. The duration of follow-up was 16 years.

High levels of stress at work increased the risk of hypertension both in men and women.
surface-enhanced Raman scattering (SERS) by optical phonons in colloidal CdSe nanocrystals (NCs)

homogeneously deposited on both arrays of Au nanoclusters and Au dimers using the Langmuir-Blodgett technique. The coverage of the deposited NCs was less than one monolayer, as determined by transmission and scanning electron microscopy. The deposition of CdSe nanocrystals on the Au dimer nanocluster arrays enabled us to study the polarization dependence of SERS. The SERS signal intensity was also investigated as a function of the distance between nanoclusters in a dimer.

SERS by optical phonons in CdSe nanocrystals showed a significant enhancement that depends resonantly on the Au nanocluster and dimer size, and thus on the localized surface plasmon resonance (LSPR) energy. The maximal SERS signal was observed for light polarization parallel to the dimer axis. The polarization ratio of the SERS signal parallel and perpendicular to the dimer axis was 20. The maximal SERS enhancement was observed for the minimal distance studied (about 10 nm), confirming the formation of SERS 'hot spots'.
Cu-rich magnesioferrite was found in vesicular basaltic trachyandesite in one of lava tubes (Duplex) that formed during the 2012–2013 eruption of the Tolbachik volcano, Kamchatka. This mineral is commonly associated with hematite, tenorite, halite, sylvite, and Ca-rich silicates (mainly, esseneite and Na-rich melilite) in high-temperature (800–1000 °C) reactionary zones (up to 100 µm) covering vesicular rocks and lava stalactites in the Duplex tube. The mineral relationships of this assemblage indicate the following crystallization sequence: Ca-rich silicates + hematite → Cu-rich magnesioferrite → tenorite → chlorides. This formed due to the reaction of hot gases containing Cu, alkalis, and Cl with solidified lava rock. The composition of magnesioferrite varies strongly in CuO (5.8–17.3 wt %; cuprospinel end-member—15–47 mol %), whereas the contents of other oxides are minor, indicating the main isomorphic substitution is Mg2+ ↔ Cu2+. Compositions with maximal CuO content nominally belong to Mg-rich cuprospinel: (Cu0.48Mg0.41Mn0.09Zn0.02Ca0.02) (Fe3+1.94Al0.03Ti0.02)O4. Increasing CuO content of the Duplex Cu-rich magnesioferrite is reflected in Raman spectra by moderate right shifting bands at ≈700–710 and 200–210 cm−1 and the appearance of an additional band at 596 cm−1. This supports the main isomorphic scheme and may indicate a degree of inversion in the spinel structure.
This paper describes the tools for supporting researchers in the development of a parallel code. The tools are based on the ontology of the knowledge area “Support for solving compute-intensive problems of mathematical physics on supercomputers”. The main result of these tools operation is a scheme for solving the problem, built according to its specification provided by the user. The scheme includes the most suitable mathematical models for solving the problem, numerical methods, algorithms, and parallel architectures, links to available fragments of a parallel code that the user can use when developing his own code. The scheme construction is carried out on the basis of ontology and expert rules built using the Semantic Web technology.
One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer.

In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus.

Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.
Proportional electroluminescence (EL) in gaseous Ar has for the first time been systematically studied in the two-phase mode, at 87 K and 1.00 atm. Liquid argon had a minor (56 ppm) admixture of nitrogen, which allowed to understand, inter alia, the effect of N2 doping on the EL mechanism in rare-event experiments using two-phase Ar detectors. The measurements were performed in a two-phase Cryogenic Avalanche Detector (CRAD) with EL gap located directly above the liquid-gas interface. The EL gap was optically read out in the Vacuum Ultraviolet (VUV), near 128 nm (Ar excimer emission), and in the near Ultraviolet (UV), at 300-450 nm (N2 Second Positive System emission), via cryogenic PMTs and a Geiger-mode APD (GAPD). Proportional electroluminescence was measured to have an amplification parameter of 109+-10 photons per drifting electron per kV overall in the VUV and UV, of which 51+-6% were emitted in the UV. The measured EL threshold, at an electric field of 3.7+-0.2 kV/cm, was in accordance with that predicted by the theory. The latter result is particularly relevant to DarkSide and SCENE dark matter search-related experiments, where the operation electric field was thereby on the verge of appearance of the S2 (ionization-induced) signal. The results obtained pave the way to the development of N2-doped two-phase Ar detectors with enhanced sensitivity to the S2 signal.
Актуальность исследования обусловлена необходимостью расширения ресурсной базы полезных ископаемых, в том числе и золота. Крупные ареалы щелочного магматизма, такие как Алдано-Становой щит, представляют особый интерес, так как часто со щелочными породами ассоциируют золоторудные месторождения, в том числе крупные и гигантские. Верхнеамгинский массив расположен в Верхнеамгинском рудном районе Алдано-Станового щита, который, в свою очередь, входит в состав Чаро-Алданской металогенетической зоны, протянувшейся более чем на 700 км с запада на восток. Характерной особенностью Верхнеамгинкого рудного района является его приуроченность к Амгинской субмеридиональной структурной зоне тектонического меланжа, отделяющей Центрально-Алданский составной террейн с востока от расположенных к западу и югу от нее соответственно Западно-Алданского и Тындинского составных террейнов.

Методы: петрографические исследования и 40Ar/39Ar датирование методом ступенчатого прогрева по монофракциям флогопитов.

Результаты. В результате петрографических исследований показано, что основные фазы мезозойского щелочного магматизма в пределах Верхнеамгинского массива представлены лейкократовыми сиенитами и дайками мезократовых лампрофиров (минетт). Результаты 40Ar/39Ar датирования показали, что образование массива происходило в несколько этапов: (1) 129,1±2,5 млн лет внедрение сиенитов; (2) 117,7±3,4 млн лет внедрение даек лампрофиров. Мезозойский магматизм, проявленный в Верхнеамгинском районе показывает сходные возрастные рубежи с магматическими процессами, проявленными на Алданском щите в мезозойскую эпоху.
A test facility for experimental simulation of transient heat load expected for ELMs type I events in ITER is developed at BINP SB RAS.

Dynamics of tungsten particles in the ablation plume is investigated by small-angle light scattering technique and using fast CCD and ICCD cameras.

The threshold of intense particle generation, sizes and velocities of particles ejected from the surface are estimated.