Hengzongshu/ArticleAgent huggingface dataset:
The purpose of this work is to determine the intratumoral distribution of miRNA expression profiles in luminal breast cancer (BC). The study included 33 certain BC cases of the luminal A or luminal B (Her2-) subtypes.

The relative expression levels of miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, and U58 were measured by RT-qPCR in four intratumor areas in each of 33 luminal BC specimens and in surrounding normal mammary gland tissues. Comparative analysis of miRNA expression levels between normal mammary gland tissue and different intratumor areas revealed that only four miRNAs (miRNA-21, -200b, -200a, -191) appear as consistently differentiating markers. A comparative analysis of miRNA expression levels between normal mammary gland tissue and the tumor border revealed statistically significant differences for ten miRNAs; 10 miRNAs show differential expression between normal mammary gland tissue and central tumor specimens; 9 miRNAs show differential expression between normal mammary gland tissue and tumor periphery 1; 13 miRNAs show differential expression between normal mammary gland tissue and tumor periphery 2. After comparing the tumor periphery 1 and tumor center, we found statistically significant differences in expression between five miRNAs and after comparing the tumor periphery 2 and tumor center, differences were observed for 12 miRNAs.

MiRNA expression levels are subject to considerable variation, depending on the intratumor area. This may explain the inconsistency in miRNA expression estimates in BC coming from different laboratories.
Dissipative solitons (also known as auto-solitons) are stable, nonlinear, time-or space-localized solitary waves that occur due to the balance between energy excitation and dissipation.

We review the theory of dissipative solitons applied to fiber laser systems. The discussion context includes the classical Ginzburg±Landau and Maxwell±Bloch equations and their modifications allowing the description of laser-cavity-produced waves.

Practical examples of laser systems generating dissipative solitons are discussed.
We investigate lateral p-n junctions, electrostatically defined in 14 nm-wide HgTe-based quantum wells (QWs) with inverted band structure. The p-n junctions resistances are close to $h/2e^2$, consistent with some previous experiments on 8-10 nm QWs, and the current-voltage characteristics are highly linear, indicating the transport via ballistic helical edge states.

Shot noise measurements are performed in order to further verify the underlying transport mechanism. We discuss the role of unknown inelastic relaxation rates in the leads and in the edge channels for the correct interpretation of the noise data.

Although the interpretation in favor of the helical edge states seems more consistent, a definite conclusion can not be drawn based on the present experiment. Our approach looks promising for the study of short quasi-ballistic edges in topological insulators (TIs) in suitable geometry.
Two new isostructural microporous coordination frameworks [Mn3(Hpdc)2(pdc)2] (1) and [Mg3(Hpdc)2(pdc)2] (2) (pdc2- = pyridine-2,4-dicarboxylate) showing primitive cubic (pcu) topology have been prepared and characterized. The pore aperture of the channels is too narrow for the efficient adsorption of N2; however, both compounds demonstrate substantially higher uptake of CO2 (119.9 mL·g-1 for 1 and 102.5 mL·g-1 for 2 at 195 K, 1 bar). Despite of their structural similarities, 2 shows a typical reversible type I isotherm for adsorption/desorption of CO2, while 1 features a two-step adsorption process with a very broad hysteresis between the adsorption and desorption curves. This behavior can be explained by a combination of density functional theory calculations, sorption, and X-ray diffraction analysis and gives insights into the further development of new sorbents showing adsorption/desorption hysteresis.
This article is about the research on gold obtained from mine wastes and other technogenic mineral formations.

The authors investigated how solid phases of gold in supergene zone transform from various deposits.

Results show the following supergene gold transformations by various physical, chemical, biological and mechanical processes occurring in the wastes. Transformations result in changes in morphology and chemical composition, and special redistribution of gold in wastes.
The prevalence of hemophilia B in the global population is approximately 1:60,000. Undifferentiated systemic mesenchymal dysplasia (uSMD) is diagnosed rather frequently, about 1:5, according to Russian authors; no data on uSMD prevalence in other countries are available. The combination of hemophilia and uSMD has grouped under the term hematomesenchymal dysplasia (HMD). This combination significantly worsens the clinical picture, prognosis, and quality of life of the patient.

A clinical case of a male patient, 5 years old with hemophilia B, severe form combined with HMD, complicated by hemothorax, abscessed pulmonary lobe hematoma has presented. The main diagnostic procedures were the assessment of the phenotypic signs of HMD in combination with laboratory and instrumental examination methods such as ultrasound, computed tomography (CT) scan, and echocardiography. Vital treatment is factor IX replacement therapy and supportive one.

This clinical example highlights the importance of clinical alertness to hereditary coagulopathies, which often lead to life threatening, sometimes disabling complications that significantly reduce the quality of life of children with hemophilia. Consequently, full-scale epidemiological studies of the prevalence of HMD in the population are an urgent task for the near future.
Oncolyic virotherapy is one of the modern experimental techniques to treat human cancers.

Here we studied the antitumor activity of wild-type Newcastle disease virus (NDV) isolates from Russian migratory birds. We evaluated the oncolytic effect of 44 NDV isolates in 4 histogenetically different human cell lines (HCT116, HeLa, A549, MCF7). The safety of the isolates was also tested in normal peripheral blood mononuclear (PBMC) cells. The viability of tumor cell lines after incubation with NDV isolates was evaluated by MTT. In vivo, we described the intratumoral activity of NDV/Altai/pigeon/770/2011 against subcutaneous non-small cell lung carcinoma using xenograft SCID mice model.

We showed that NDV could selectively kill malignant cells without affecting healthy cells. All cell lines, except for normal PBMC primary cells, had different degrees of susceptibility to NDV infection. Seven NDV strains had the highest oncolytic activity, and some NDV strains demonstrated oncolytic selectivity for different cell lines. All animals were responsive to therapy. Histology confirmed therapy-induced destructive changes and growing necrotic bulk density in tumor tissue. Our findings indicate that wild-type NDV strains selectively kill tumor cells with no effect on healthy PBMC cells, and intratumoral virotherapy with NDV suppresses the subcutaneous tumor growth in SCID mice.
The results of experimental investigations of the influence of distributed suction through a finely perforated section of a symmetric airfoil on the spatial development of disturbances in the boundary layer are presented.

A spectral analysis of disturbances showed that suction reduces the intensity of high-frequency fluctuations for both natural and forced disturbances.

It was found that distributed suction reduces by 10 times the intensity of natural disturbances of the boundary layer and by 20 times the intensity of artificial disturbances generated by an external acoustic field. It was found that the distributed suction affects the average flow – when the suction is on, the separation of the boundary layer near the trailing edge of the wing is eliminated. It was found that distributed suction significantly affects the mean flow, up to eliminating the boundary-layer separation near the trailing edge of the wing.
This paper is devoted to an experimental study of the dynamics of the nucleate boiling in a droplet of aqueous solution of LiBr salt. As the concentration of LiBr salt increases, the growth rate of the bubbles decreases and the boiling completely stops when a high salt concentration is reached. An increase in the concentration of salt in the liquid layer of the bottom of the bubble leads to a decrease in the rate of increase in the diameter of the bubble, and a dry spot is not formed. The growth rate of a bubble (v) in a water droplet is somewhat higher than one for a salt solution for t > 0.2-0.3 s. The difference of v for the salt solution from curve 3 increases sharply when t < 0.1 s. For the first time, four regimes of the nucleate boiling in LiBr solution droplet were detected.
The article is devoted to the problems of memory policy in the USSR of the second half of the 1930s.

The correlation of officially broadcast ideological images of the past with the ideological attitudes of ordinary Soviet citizens has been studied on the materials of Western Siberia. Two main goals of using images of the past in the mobilization campaigns of 1934-1939 were identified: proving the regularity of the Bolsheviks' coming to power and contrasting Soviet modernity with the pre-revolutionary past. The circle of positive and negative images of events and historical figures in Soviet propaganda is studied. The main forms of using images of the past in propaganda are established: separate anniversary campaigns and secondary support of the main political campaigns. The causes of memory conflicts during the ideological influence of the population misunderstanding, distrust, disagreement and inattention are investigated. The social, value and ideological causes of conflicts are established, their forms are considered.

It is proved that the images of progressive figures who 'confirmed' the rightness of the Bolsheviks were positive; the images of 'enemies' of revolutions and 'working people' were negative. The conclusion is made about the forced and unstable nature of the implementation of the memory policy, about its utilitarian purpose and about the relatively weak mutual influence of the memory policy and personal images of the past in the Soviet society. The thesis is formulated about the parallel existence in the USSR society of official narratives about the past and multiple personal images of history - both national, local and family.
As is found, the combustion of microjet is dominated by the generation of "bottleneck-flame region" that is in agreement with our previous observations on the diffusion combustion of subsonic hydrogen microjets.

Experimental data on combustion of a round hydrogen microjet in a cocurrent coaxial air jet are presented.

Transformation of the spherical "bottleneck-flame region" to a cylindrical one is observed. At supersonic combustion of the round hydrogen microjet, supersonic cells are generated both in the microjet and in the cocurrent coaxial air flow. A feature of the combustion process is the flame lift-off from the nozzle exit.
The article reflects the author’s methodological position that the phenomena of uncertainty and risk are considered within the context of decision-making problems. It is shown that the ability to quantify the probability of the occurrence of possible events makes it possible to fundamentally distinguish between risk situations and situations of uncertainty.

Risk is the result of a decision and is always associated with a person who not only makes a choice, but also estimates the probabilities of possible outcomes and related losses. Risk is an integral indicator that combines estimates of both the probability of a decision and of the quantitative characteristics of its consequences.

Every person has her own system of preferences, therefore there is no universal functional integrating estimates of probabilities and consequences. As a result, a person chooses the alternative that most closely matches her goals, assessments and value system. The typology of uncertainties in decision-making tasks, previously developed by the author, is supplemented.
We derive the Weierstrass (or spinor) representation for surfaces in three-dimensional Lie groups Nil, \tilde{SL}_2, and Sol with Thurston's geometries and establish the generating equations for minimal surfaces in these groups. By using the spectral properties of the corresponding Dirac operators we find analogs of the Willmore functional for surfaces in these geometries.
The data on the bubble dynamics was compared with well-known classic growth correlation formulas.

The vapour bubble dynamics during subcooled flow boiling in a flat microchannel with the height of 0.6 mm was investigated using high-speed visualization. Nucleate flow boiling was maintained by localized heat source.

The obtained data have shown that the bubble size can reach the channel height in about 0.1 ms, which can lead to heat transfer crisis in channels with local heating.
The article considers the structure, characteristics and gold content of the 'Ojerelie' deposit according to the data of geological reports, published articles, fund materials and internal documents

which allowed to summarize and briefly present the geological structure of this area
Exosomes are directly involved in governing physiological and pathological conditions of an organism by transferring information (proteins, microRNA, etc.) from producing to receiving cells.

We evaluated the influence of protein cargoes of exosomes from plasma, and exosomes from the total blood of healthy females (HFs) and breast cancer patients (BCPs), on crucial steps of tumor progression: EMT, cell proliferation, invasion, cell migration, stimulation of angiogenesis and immune response. We conducted a mass spectrometric analysis of proteomic content of exosomes isolated from samples using ultrafiltration and ultracentrifugation. Their nature has been verified using cryo-electron microscopy and flow cytometry. Bioinformatics analysis showed that 84% of common exosomal proteins were of cytoplasmic and vesicle origin. They perform functions of protein binding and signaling receptor binding, and facilitated the processes of the regulated exocytosis and vesicle-mediated transport. We observed that metabolism-related signaling pathways were enhanced in the exosome-mediated intracellular communication.

Half of the identified exosomal proteins from blood of HFs and BCPs are involved in crucial steps of the tumor progression: EMT, cell proliferation, invasion, cell migration stimulation of angiogenesis, and immune response. Moreover, we revealed that proteomic profiles of exosomes from HF total blood were enriched with proteins inhibiting EMT, cell migration, and invasion. Tumor diagnostic/prognostic protein markers accounted for 47% of the total composition of cell-surface-associated exosomes (calculated as the difference between the total blood exosomes and plasma exosomes) from BCP blood. Breast cancer-associated proteins were equally represented in the blood cell-surface-associated exosomes and in the plasma exosomes from BCPs. However, hyper-expressed proteins predominate in the blood cell-surface-associated exosomes as compared to the plasma exosomes (64% vs. 14%). Using breast cancer proteins data from the Human Protein Atlas (HPA) (www.proteinatlas.org/), three favorable (SERPINA1, KRT6B, and SOCS3) and one unfavorable (IGF2R) prognostic protein markers were found in the BCP total blood exosomes. Further studies will be needed to determine whether identified new exosomal proteins from BCP blood are potential breast cancer diagnostic/prognostic markers or novel therapeutic targets.
A 3D model of laser welding proposed before by the authors was extended to the case of welding of metallic plates made of dissimilar materials with a composite multilayer intermediate insert.

The model simulates heat transfer in the welded plates and takes into account phase transitions. It was proposed to select the composition of several metals and dimensions of the insert to avoid the formation of brittle intermetallic phases in the weld joint negatively affecting its strength properties. The model accounts for key physical phenomena occurring during the complex process of laser welding. It is capable to calculate temperature regimes at each point of the plates. The model can be used to select the welding parameters reducing the risk of formation of intermetallic plates. It can forecast the dimensions and crystalline structure of the solidified melt. Based on the proposed model a numerical algorithm was constructed. Simulations were carried out for the welding of titanium and steel plates with a composite insert comprising four different metals: copper and niobium (intermediate plates) with steel and titanium (outer plates). The insert is produced by explosion welding.

Temperature fields and the processes of melting, evaporation, and solidification were studied.
The Vetrovoy Isthmus and the Lvinaya Past' Bay on the Iturup island (Kuril island arc) are the results of large Plinian eruptions of compositionally similar dacitic magmas. This study is devoted to a comparative analysis of the storage and crystallization conditions for magma reservoirs, which were a source of large-scale explosive eruptions. The plagioclase is most informative mineral in studying of the melt evolution. The studied plagioclases possess a complex zoning patterns, which are not typical for silicic rocks in island-arc systems. It was shown that increase of Ca in the plagioclase up to unusually high An95 is related to increase of H2O pressure in both volcanic magma chambers. The study revealed that minerals of the Vetrovoy Isthmus and Lvinaya Past' crystallized from compositionally similar melts. Despite the compositional similarity of the melts, the phenocryst assemblage of the Lvinaya Past' differs from the Vetrovoy Isthmus by the presence of the amphibole, which indicates that the pressure in the magmatic chamber exceeded 1-2 kbar at a 4-6 wt. % of H2O in the melt. The rocks of the Vetrovoy Isthmus do not contain amphibole phenocrysts, but melt and fluid inclusions assemblages in plagioclase demonstrate that the magma degassed in the course of evolution. This is an indication that the pressure did not exceed significantly 1-2 kbar.
Methods for the synthesis of binuclear [Cu(hfac)2LEt]2 and tetranuclear [[Cu(hfac)2]4(LEt)2] heterospin compounds based on copper hexafluoroacetylacetonate [Cu(hfac)2] and 2-(4-ethylpyridin-3-yl)-4,5-bis(spirocyclopentyl)-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LEt), were developed. The crystals of the complexes are elastic and do not crash during repeated cooling–heating cycles. It was found that a singlet–triplet conversion occurred in all of the {Cu(II)–O•–N<} exchange clusters in the molecules of the binuclear [Cu(hfac)2LEt]2 which led to spin coupling with cooling. The transition occurred in a wide temperature range with a maximum gradient ΔχT at ≈180 K. The structural transformation of the crystals takes place at T < 200 K and is accompanied by the lowering of symmetry from monoclinic to triclinic, twinning, and a considerable shortening of the Cu–ONO distance (2.19 and 1.97 Å at 295 and 50 K, respectively). For the tetranuclear [[Cu(hfac)2]4(LEt)2], two structural transitions were recorded (at ≈154 K and ≈118 K), which led to a considerable change in the spatial position of the Et substituent in the nitronyl nitroxyl fragment. The low-temperature process was accompanied by a spin transition recorded as a hysteresis loop on the χT(T) curve during the repeated cooling–heating cycles (T½↑ = 122 K, T½↓ = 115 K). This transition is unusual because it causes spin coupling in half of all of the {>N–•O–Cu2+} terminal exchange clusters, leading to spin compensation for only two paramagnetic centers of the six centers in the molecule.
In this work we study the properties of the surface, obtained by applying Noa 81 photoresist at different temperatures of the substrate.

The measurement of free energy was conducted by the Owens, Wendt, Rabel and Kaelble method under isothermal conditions.

The paper presents the obtained data on contact angle for different temperatures.
The need for its introduction is dictated by non-uniqueness of answers to the problems with interval data.

The paper presents a construction of a quantitative measure of variability for parameter estimates in the data fitting problem under interval uncertainty. A substantiation of the new variability measure is given, its application and motivations are discussed.

It shows the degree of variability and ambiguity of the estimate. Several examples and a series of numerical tests are considered, showing the features of the new characteristic and the specifics of its use.
This study presents new whole rock major and trace element, Sr-Nd isotopic, petrographic, and geochronologic data for seven latest Permian (Changhsingian)–Late Triassic (Carnian) granitoid intrusions of the northwestern and northeastern Taimyr Peninsula in the Russian High Arctic.

U-Pb zircon ages, obtained using secondary ion mass spectrometry (SIMS), sensitive high-resolution ion microprobe (SHRIMP), and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), define the crystallization age of the Taimyr intrusions studied as ranging from ca. 253 Ma to 228 Ma, which suggests two magmatic pulses of latest Permian–Early Triassic and Middle–Late Triassic age. Ar-Ar dating of biotite and amphibole indicate rapid cooling of the intrusions studied, but Ar-Ar ages of several samples were reset by secondary heating and hydrothermal activity induced by the Middle–Late Triassic magmatic pulse. Petrographic data distinguish two groups of granites: syenite–monzonites and granites–granodiorites. Sr-Nd isotopic data, obtained from the same intrusions, show a variation of initial (87Sr/86Sr)i ratios between 0.70377 and 0.70607, and εNd(t) values range between –6.9 and 1.2.

We propose that the geochemical and isotopic compositions of the Late Permian–Triassic Taimyr granites record the existence of a magma mush zone that was generated by the two pulses of Siberian Traps large igneous province (LIP) magmatism.
The aim of the study is to compare behavioral and EEG reactions of primary school-aged children during the recognition of syntactic errors in emotionally (positively or negatively) colored sentences that appeal to the choice of the child differently. 20 children (mean age 9,0±0,3 years, 12 boys, 8 girls) were examined. We found out that the children with a high quality of solving a linguistic task concentrate all their attention on finding an error in the sentences, and children with a low quality of solving a task demonstrate increased emotionality, possibly connected with their unsuccessfulness. The strongest EEG reactions in the ranges of alpha- and theta- rhythms were recorded in children with slow speed and bad quality of the solution of the task. The recognition of sentences with negative emotions took longer than sentences with positive emotions. The increase of emotions (synchronization in theta range) during the recognition of negative sentences was provoked by the expectation of failure and “identification” with it. The children found the mistake better in the sentences with their own choice than in the sentences that describes the forced-choice situation. Desynchronization (i.e. decrease in the spectral power) and synchronization (i.e. increase in spectral power) was detected on the EEG in the alpha-rhythm range. Desynchronization was associated with the recognition of sentences describing the children’s own choice; synchronization was recorded when recognizing sentences describing the forced-choice situation.