Hengzongshu/ArticleAgent huggingface dataset:
Application of the direct simulation Monte Carlo (DSMC) method for calculating the flow near superorbital space vehicles at the high-altitude (above 70 km) part of the trajectory is considered.

An example of application of various models of the ionized flow near the vehicle during its reentry into the Earth's atmosphere for calculating the flow of the Stardust sample return capsule (entry speed 12.4 km/s) is presented. The influence of numerical models on the values of convective and radiative heat fluxes is investigated.

It is found that the characteristic feature of such high-speed flows is the mutual influence of ionization and radiation processes, which must be taken into account in modeling.
The work is devoted to numerical simulation of the stationary stress-strain state of lattice cylindrical shells made of unidirectional carbon fiber reinforced plastics and to their optimal design. After averaging stiffness characteristics of lattice structure, the displacement and stress formulations for continuum anisotropic equivalents of lattice shells are given on the basis of classical relations of 3D theory of elasticity. While using a special fast pseudo-spectral algorithm, the solutions to problems of axial compression of anisogrid shells are obtained and compared one to another. The algorithm provides exponential decrease of error of approximation and requires small computational resources. Using this algorithm we have found the optimal geometrical parameters of structure ensuring its bearing capacity under given non-uniform loads.
Frequent discordant phylogenies inferred from different loci, as well as the presence of sufficiently diverged gene variants within a single species isolate are indicative of potentially frequent non-monophyly in the genus Pinus.Interspecies hybridisation and incomplete lineage sorting have been suggested as possible explanations for the observed phylogenetic discrepancies.However, there is no direct evidence to support any of the proposed scenarios for the Eurasian five-needle pines.

We used natural hybrids between Pinus sibirica and P. pumila, as well as their parental species, as a model to reproduce the scenario of non-monophyly in the subgenus Strobus.Three non-linked nuclear DNA loci (LEA, AGP6 and 4CL) were applied to detect introgressive alleles and to genetically discriminate the studied species.

Comparative sequence analyses revealed two clusters of species-specific alleles for each of the markers, characteristic for either P. sibirica or P. pumila.No hybrid-specific alleles were found.We also found no hybrids with a genotype characteristic of only one of the parental species for all three loci.On average, the hybrids were characterised by an equal ratio of alleles from the P. sibirica and P. pumila clusters.We reveal that some trees of pure species originating from allopatric locations have non-specific loci that can be a result of genetic exchange between these species in the distant past or incomplete lineage sorting.
We investigate the superradiance effects in three-dimensional topological insulator HgTe with conducting surface states. We demonstrate that the superradiance can be explained using the classical electrodynamic approach. Experiments using the continuous-wave spectroscopy allowed us to separate the energy losses in the system into intrinsic and radiation losses, respectively. These results demonstrate that the superradiance effects are not sensitive to the details of the band structure of the material.
Recently developed two-dimensional colloidal semiconductor nanocrystals, or nanoplatelets (NPLs), extend the palette of solution-processable free-standing 2D nanomaterials of high performance. Growing CdSe and CdS parts subsequently in either side-by-side or stacked manner results in core–crown or core/shell structures, respectively. Both kinds of heterogeneous NPLs find efficient applications and represent interesting materials to study the electronic and lattice excitations and interaction between them under strong one-directional confinement.

Here, we investigated by Raman and infrared spectroscopy the phonon spectra and electron–phonon coupling in CdSe/CdS core/shell and core–crown NPLs. A number of distinct spectral features of the two NPL morphologies are observed, which are further modified by tuning the laser excitation energy Eexc between in- and off-resonant conditions.

The general difference is the larger number of phonon modes in core/shell NPLs and their spectral shifts with increasing shell thickness, as well as with Eexc. This behaviour is explained by strong mutual influence of the core and shell and formation of combined phonon modes. In the core–crown structure, the CdSe and CdS modes preserve more independent behaviour with only interface modes forming the phonon overtones with phonons of the core.
We lay the foundation for a version of $r$-spin theory in genus zero for Riemann surfaces with boundary. In particular, we define the notion of $r$-spin disks, their moduli space, and the Witten bundle; we show that the moduli space is a compact smooth orientable orbifold with corners, and we prove that the Witten bundle is canonically relatively oriented relative to the moduli space. In the sequel to this paper, we use these constructions to define open $r$-spin intersection theory and relate it to the Gelfand–Dickey hierarchy, thus providing an analog of Witten’s $r$-spin conjecture in the open setting.
The work aims to check one of the assumptions under which the kinetic equation for water waves was derived in order to understand whether it can be applied to the situations described by the Phillips spectrum.

We evaluate a spectral line width of the spectrum from the simulations in the framework of primordial dynamical equations at different levels of nonlinearity in the system, corresponding to the weakly turbulent Kolmogorov–Zakharov spectra ω−4, Phillips spectra ω−5, and intermediate cases.

It is shown that, even in the case of relatively high average steepness, when the Phillips spectrum is present in the system, the spectral lines are still very narrow, at least in the region of the direct cascade spectrum. It allows us to state that, even in the case of the Phillips spectrum, one of the assumptions used for the derivation of the Hasselmann kinetic equation is still valid, at least in the case of moderate whitecapping.
The paper discusses methods that ensure the execution of only correct and legal control commands in the process control system. Protection of the integrity of the APCS software at all nodes of the industrial network, including protection against unauthorized substitution, is carried out by checking the control parameters of the software during their startup. Protection of control commands from distortions during transmission over the network is realized by double coding at different levels of the system. Protection against the submission of unauthorized control commands to technological equipment is carried out by recognizing these commands in the lower-level subsystem and comparing their current characteristics with the control ones. A certain contribution to the safety of the process control system is made by the use of a secure execution environment – OS CentOS 7.
Two-phase Cryogenic Avalanche Detectors (CRADs) with combined THGEM/GAPD-matrix multiplier have become an emerging technique in rare-event experiments such as those of coherent neutrino-nucleus scattering and dark matter search.

In this work we continue to study the performance of the two-phase CRAD in Ar with THGEM/GAPD-matrix charge/optical readout. The matrix was composed of a 3×3 array of GAPDs (Geiger-mode APDs), optically recording THGEM-hole avalanches in the Near Infrared (NIR).

Gain, time, amplitude and spatial resolution properties of the combined multiplier are described.
Features of methane hydrate self-preservation in the dispersions prepared from water in oil emulsions from two deposits in East Siberia were studied. Under experimental conditions, substantial self-preservation of the hydrate is observed in the dispersion based on oil 1, while the effect is weakened in the dispersions based on oil 2. It is demonstrated that the observed difference is connected with the presence of Span 80 surfactant in water in oil 2 emulsion.
The changes in the renal function leading to a reduction of medullary blood flow can have a great impact on sodium and water homeostasis and on the long-term control of arterial blood pressure.

The RNA-Seq approach was used for transcriptome profiling of the renal medulla from hypertensive ISIAH and normotensive WAG rats to uncover the genetic basis of the changes underlying the renal medulla function in the ISIAH rats being a model of the stress-sensitive arterial hypertension and to reveal the genes which possibly may contribute to the alterations in medullary blood flow.

Multiple DEGs specifying the function of renal medulla in ISIAH rats were revealed. The group of DEGs described by Gene Ontology term 'oxidation reduction' was the most significantly enriched one. The other groups of DEGs related to response to external stimulus, response to hormone (endogenous) stimulus, response to stress, and homeostatic process provide the molecular basis for integrated responses to homeostasis disturbances in the renal medulla of the ISIAH rats. Several DEGs, which may modulate the renal medulla blood flow, were detected. The reduced transcription of Nos3 pointed to the possible reduction of the blood flow in the renal medulla of ISIAH rats. The generated data may be useful for comparison with those from different models of hypertension and for identifying the common molecular determinants contributing to disease manifestation, which may be potentially used as new pharmacological targets.
Despite the large number of existing methods of the diagnosis of the brain, brain remains the least studied part of the human body. Electroencephalography (EEG) is one of the most popular methods of studying of brain activity due to its relative cheapness, harmless, and mobility of equipment. While analyzing the EEG data of the brain, the problem of solving of the inverse problem of electroencephalography, the localization of the sources of electrical activity of the brain, arises. This problem can be formulated as follows: according to the signals recorded on the surface of the head, it is necessary to determine the location of sources of these signals in the brain. The purpose of my research is to develop a software system for localization of brain activity sources based on the joint analysis of EEG and sMRI data. There are various approaches to solving of the inverse problem of EEG. To obtain the most exact results, some of them involve the use of data on the individual anatomy of the human head – structural magnetic resonance imaging (sMRI data). In this paper, one of these approaches is supposed to be used – Electromagnetic Spatiotemporal Independent Component Analysis (EMSICA) proposed by A. Tsai. The article describes the main stages of the system, such as preprocessing of the initial data; the calculation of the special matrix of the EMSICA approach, the values of which show the level of activity of a certain part of the brain; visualization of brain activity sources on its three-dimensional model.
The dehydration of serpentine mineral antigorite, Mg2.8Si2O5(OH)3.6, is regarded as the key step in metamorphic transformation of ultramafic hydrated rocks in subduction zones, which affects seismicity and feeds volcanic activity. The abundance of alkali-chloride brines derived from deep subduction/upper mantle sources implies the possibility of a large control of the H2O activity by the dissolved salts. The present study examines the effect of alkali chlorides, lowering the H2O activity in fluid, on antigorite stability at high pressure. The decomposition of natural antigorite (Ural) in the presence of a halite-saturated NaCl-H2O fluid was studied up to 3 GPa and 700 °C by in situ X-ray diffraction combined with resistively heated diamond-anvil cell. Reference experiments were also performed on salt-free sample. At 1.5–3 GPa in the presence of halite-saturated fluid (XNaCl ≈ 0.15), antigorite decomposes to an intermediate product assemblage of talc+forsterite at about 550 °C, which is ≈150 °C lower compared to salt-free H2O-unsaturated system. Such a low-temperature shift supports the previous models of a broadened P-T area of serpentinite dehydration in the subducting slab. In addition, the present experiments reveal active dissolution of the product Mg silicates, first of all forsterite, in the NaCl-H2O fluid at 600–700 °C/1.5–3 GPa. This implies that dehydrated serpentinites are a potential source of fluids enriched in MgO and SiO2, which play an important role in deep metasomatic processes.
Evolution of multicellular organisms was accompanied by multiple extinctions, after which the survived phyletic lineages started to conquer the free ecological space. The question arises: how the selection for adaptation to new environment could affect the organism morphology? The rate of evolutionary change of a structure depends predominantly on the number of loci that control its development. As this number increased in the course of evolution, it is hypothesized that the evolutionary trend for complication of organisms is the consequence of selection for the rate of evolution.
We compute perturbative corrections to matching coefficients of QCD to heavy quark effective theory (HQET) for the matrix element of the $\mathrm{\ensuremath{\Delta}}B=2$ operator that determines the mass difference in ${B}^{0}\text{\ensuremath{-}}{\overline{B}}^{0}$ system of states.

This involves the technical point of choosing the operator basis in HQET, separating physical operators from evanescent ones.

We obtain an analytical result for some of the two-loop corrections at order ${\ensuremath{\alpha}}_{s}^{2}$.
The stromal elements of a malignant tumor can promote cancer progression and metastasis. The structure of the tumor stroma includes connective tissue elements, blood vessels, nerves, and extracellular matrix (ECM). Some of the cellular elements of the tumor stroma are cancer-associated fibroblasts (CAFs). The origin and function of CAFs have been actively studied over the past thirty years.

CAFs produce collagen, the main scaffold protein of the extracellular matrix. Collagen in the tumor stroma stimulates fibrosis, enhances the rigidity of tumor tissue, and disrupts the transmission of proliferation and differentiation signaling pathways. CAFs control tumor angiogenesis, cell motility, tumor immunogenic properties, and the development of resistance to chemo- and immunotherapy. As a result of metabolic adaptation of rapidly growing tumor tissue to the nutrients and oxygen deprivation, the main type of energy production in cells changes from oxidative phosphorylation to anaerobic glycolysis. These changes lead to sequential molecular alterations, including the induction of specified transcriptional factors that result in the CAFs activation. The molecular phenotype of activated CAFs is similar to fibroblasts activated during inflammation. In activated CAFs, alpha-smooth muscle actin (α-SMA) is synthetized de novo and various proteases and fibronectin are produced.

Since CAFs are found in all types of carcinomas, these cells are potential targets for the development of new approaches for anticancer therapy. Some CAFs originate from resident fibroblasts of the organs invaded by the tumor, while others originate from epithelial tumor cells, which are undergoing an epithelial-mesenchymal transition (EMT). To date, many molecular and metabolic inducers of the EMT have been discovered including the transforming growth factor-beta (TGF-β), hypoxia, and inflammation. This review classifies modern concepts of molecular markers of CAFs, their functional features, and discusses the stages of epithelial-mesenchymal transition, and the potential of CAFs as a target for antitumor therapy.
Introduction . Multiple sclerosis is a chronic immune-mediated disease of the central nervous system with disseminated foci of demyelination and progressive neurodegeneration; it is the most common demyelinating disease and the leading cause of disability of neurological patients of a young age, characterized by a wave-like course with alternating periods of remission and relapse. Currently, there is a discussion about the participation of vascular changes in the formation of neurological disorders and about the possibility of correction of therapeutic approaches in connection with the revealed microcirculatory disorders. Perfusion MRI allows you to evaluate hemodynamics at the capillary level in vivo . Purpose . To evaluate perfusion changes in foci of demyelination in multiple sclerosis using the method of dynamic susceptibility contrast (DSC). Materials and methods . The MR study was carried out on a super-high-angle MR-scanner «Ingenia» («Philips») 3 Tesla. The study included 30 healthy volunteers and 80 patients with demyelinating disease from 18 to 48 years old (average age was 34,6±8,02 years). Quantitative and qualitative assessment of perfusion indices in foci of demyelination was carried out. Results. In the active foci of demyelination, an increase in the speed and volume of cerebral blood flow is noted, the most pronounced changes in patients with clinically isolated syndrome. Inactive foci, marked hypoperfusion is noted. Discussion . Evaluation of cerebral perfusion allows a new look at the role of the vascular component in the formation of focal inflammatory changes in the brain in multiple sclerosis, which can determine a new direction of pathogenetic treatment. Conclusion . Perfusion data complements routine MRI and provides a comprehensive assessment of the neurovascular system.
Background Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.

Methods We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m 2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression.

Results Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. Conclusions We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample.
Tick-borne encephalitis (TBE) is a viral infectious disease caused by tick-borne encephalitis virus (TBEV). TBEV infection is responsible for a variety of clinical manifestations ranging from mild fever to severe neurological illness. Genetic factors involved in the host response to TBEV that may potentially play a role in the severity of the disease are still poorly understood. In this study, using whole-exome sequencing, we aimed to identify genetic variants and genes associated with severe forms of TBE as well as biological pathways through which the identified variants may influence the severity of the disease. Whole-exome sequencing data analysis was performed on 22 Russian patients with severe forms of TBE and 17 Russian individuals from the control group. We identified 2407 candidate genes harboring rare, potentially pathogenic variants in exomes of patients with TBE and not containing any rare, potentially pathogenic variants in exomes of individuals from the control group. According to DAVID tool, this set of 2407 genes was enriched with genes involved in extracellular matrix proteoglycans pathway and genes encoding proteins located at the cell periphery. A total of 154 genes/proteins from these functional groups have been shown to be involved in protein-protein interactions (PPIs) with the known candidate genes/proteins extracted from TBEVHostDB database. By ranking these genes according to the number of rare harmful minor alleles, we identified two genes (MSR1 and LMO7), harboring five minor alleles, and three genes (FLNA, PALLD, PKD1) harboring four minor alleles. When considering genes harboring genetic variants associated with severe forms of TBE at the suggestive P-value < 0.01, 46 genes containing harmful variants were identified. Out of these 46 genes, eight (MAP4, WDFY4, ACTRT2, KLHL25, MAP2K3, MBD1, OR10J1, and OR2T34) were additionally found among genes containing rare pathogenic variants identified in patients with TBE; and five genes (WDFY4, ALK, MAP4, BNIPL, EPPK1) were found to encode proteins that are involved in PPIs with proteins encoded by genes from TBEVHostDB. Three genes out of five (MAP4, EPPK1, ALK) were found to encode proteins located at cell periphery. Whole-exome sequencing followed by systems biology approach enabled to identify eight candidate genes (MAP4, WDFY4, ACTRT2, KLHL25, MAP2K3, MBD1, OR10J1, and OR2T34) that can potentially determine predisposition to severe forms of TBE. Analyses of the genetic risk factors for severe forms of TBE revealed a significant enrichment with genes controlling extracellular matrix proteoglycans pathway as well as genes encoding components of cell periphery.