Hengzongshu/ArticleAgent huggingface dataset:
Rhabdomyolysis is a very rare and most severe form of statin-induced muscle adverse event characterized by muscle pain, muscle necrosis with myoglobinemia and/or myoglobinuria with a very high risk of acute kidney injury and death. The article presents a case report of developing rhabdomyolysis in a middleaged female patient with hypertension, decompensated type 2 diabetes and albuminuria. A 60-year-old woman was admitted to the hospital for emergency indications with complaints of severe muscle weakness that began in the neck, which spread over several days to the upper and lower extremities, with a symptoms progression up to paresis. According to the appointment of a primary care physician, three months before hospitalization, the patient was switched from therapy with European generic brand-name rosuvastatin 20 mg to the Russian generic unbranded atorvastatin in the same dose (20 mg), which is not comparable in lipid-lowering effect. In a laboratory study, an increase in creatine phosphokinase level by 348 times (50462 U/L) of upper normal limit in combination with severe hypokalemia 1б7 mmol/L in the absence of renal dysfunction was recorded. Cancellation of statin, metformin and empagliflozin, intensive infusion therapy and treating electrolyte imbalance made it possible to prevent the development of acute renal damage, life-threatening arrhythmias and completely stop muscle complaints within a few days. The patient was discharged from the hospital on the 23 rd day with reference clinical and laboratory values, including creatine phosphokinase. This case emphasizes the importance of maintaining clinical suspicion regarding rhabdomyolysis in patients receiving statin therapy in the presence of risk factors (in this case, female sex, hyperglycemia, chronic kidney disease, concomitant therapy), as well as the relevance of timely diagnosis and treatment of this condition.
In this paper, an analytical theory for the diffraction of a Bessel beam of arbitrary order Jl(κr) on a 2D amplitude grating is presented. The diffraction pattern behind the grating turned out to be more complicated in comparison with the classical Talbot effect observed under illumination by a plane wave. In particular, the patterns in the main and fractional Talbot planes under certain conditions that are found in the article, are lattices of ring microbeams, the diameters of which depend on the period of the grating, the diameter of the illuminating beam, the number of the Talbot plane, and the topological charge l. For the rings near the optical axis, the latter reproduces l of the illuminating beam. The diffraction patterns observed in experiments on the Novosibirsk free electron laser behind gratings with periods of 1 to 6 mm, illuminated by zero- to second-order Bessel beams at a radiation wavelength λ = 141 µm, are in good agreement with both theoretical predictions and numerical calculations. We emphasize that an analytical theory based on the scalar theory of diffraction perfectly describes resulting diffraction patterns with hole diameters down to 0.25 mm, which are less than 2λ, when, formally speaking, the scalar theory becomes incorrect. Since the Laguerre–Gaussian beams can be represented as a superposition of Bessel beams, results of this paper can be applied to analysis of the Talbot effect with the Laguerre–Gaussian beams. A regular lattice of ring-like vortex microbeams, which can be formed in the Talbot planes, can be applied, for example, to creation of a lattice of optical traps, transmission of orbital angular momentum to elements of micromechanical devices, and to launching surface plasmon polaritons on an array of metal wires by 'the end-fire coupling technique'.
The optical properties of a number of Hg1-xCdxTe bulk epilayers (x = 0.152 - 0.23) and heterostructures with quantum wells (QW) based on narrow gap HgCdTe are examined aiming to reveal the prospects of such structures for laser development in long wave infrared and very long wave infrared ranges. Experimental evidence of long wavelength superluminescence, i.e. amplification of spontaneous emission, at 8.4 μm in narrow gap HgCdTe bulk epitaxial film at 100 K is reported. Employing heterostructures with QW is demonstrated to be promissory for furthering the radiation wavelength to 10 - 30 μm range.
The thermophilic strain of the genus Geobacillus, Geobacillus icigianus is a promising bacterial chassis for a wide range of biotechnological applications. In this study, we explored the metabolic potential of Geobacillus icigianus for the production of 2,3-butanediol (2,3-BTD), one of the cost-effective commodity chemicals.

Here we present a genome-scale metabolic model iMK1321 for Geobacillus icigianus constructed using an auto-generating pipeline with consequent thorough manual curation. The model contains 1321 genes and includes 1676 reactions and 1589 metabolites, representing the most-complete and publicly available model of the genus Geobacillus.

The developed model provides new insights into thermophilic bacterial metabolism and highlights new strategies for biotechnological applications of the strain. Our analysis suggests that Geobacillus icigianus has a potential for 2,3-butanediol production from a variety of utilized carbon sources, including glycerine, a common byproduct of biofuel production. We identified a set of solutions for enhancing 2,3-BTD production, including cultivation under anaerobic or microaerophilic conditions and decreasing the TCA flux to succinate via reducing citrate synthase activity. Both in silico predicted metabolic alternatives have been previously experimentally verified for closely related strains including the genus Bacillus.
Model experimental studies are presented for the flow field of a single jet, the flow parameters of a block jet, the pressure distribution on the bottom screen, and the parameters of the jet flow from a model nozzle. When expanding into a vacuum and/or a highly rarefied medium, the conditions for reproducing the relative gas pulse value of the full-scale nozzle block section are met. It is shown that when using specific similarity criteria, it is possible to experimentally model the supersonic jet outflow processes of space vehicles on small-sized laboratory vacuum installations, similar to the one created at Novosibirsk State University. Simulation results using spectral density measurements based on the glow excited by a focused electron beam, longitudinal and transverse jet density profiles obtained using modern scanning technology, as well as measurements of bottom pressure near the nozzle block are given. The possibilities and features of each applied registration method are discussed.
A combination of experimental quasi-elastic neutron scattering (QENS) and deuterium solid-state nuclear magnetic resonance (2H NMR) techniques was used to uncover the molecular mobility of benzene confined in UiO-66 (Zr) MOF with a 3D cage-window-cage type porous network topology. We have shown that tetrahedral and octahedral cages of UiO-66 offer notably different states of confinement for benzene. Below 163 K, the guest molecules of benzene are represented by two different dynamic states: in the smaller (tetrahedral) cage the benzene is able to exhibit only anisotropic C6 rotation and some limited librations. In the octahedral cage, there is enough space for additional C2 axial rotation and the isotropic random reorientation. Rotational motions have been characterized by the rate constants and corresponding activation energies. The two dynamic states merge as the temperature increases due to translational jump diffusion with the limiting step being the passage through the window between the cages. Both techniques show similar activation barrier for the diffusion of 25–27 kJ mol–1 and a diffusion coefficient D = 3.3 × 10–11 m2 s–1 at 400 K. The diffusion process is described by a migration via 1 nm long jumps among octa- and tetrahedral cages. The 2H NMR gives the correlation times for both the elementary step of diffusion (jump exchange between neighboring octa- and tetrahedral cages) and ≈58 time slower long-range isotropic migration process.
The aim of the study is to compare behavioral and EEG reactions of primary school-aged children during the recognition of syntactic errors in emotionally (positively or negatively) colored sentences that appeal to the choice of the child differently.

20 children (mean age 9,0±0,3 years, 12 boys, 8 girls) were examined. Desynchronization (i.e. decrease in the spectral power) and synchronization (i.e. increase in spectral power) was detected on the EEG in the alpha-rhythm range.

We found out that the children with a high quality of solving a linguistic task concentrate all their attention on finding an error in the sentences, and children with a low quality of solving a task demonstrate increased emotionality, possibly connected with their unsuccessfulness. The strongest EEG reactions in the ranges of alpha- and theta- rhythms were recorded in children with slow speed and bad quality of the solution of the task. The recognition of sentences with negative emotions took longer than sentences with positive emotions. The increase of emotions (synchronization in theta range) during the recognition of negative sentences was provoked by the expectation of failure and 'identification' with it. The children found the mistake better in the sentences with their own choice than in the sentences that describes the forced-choice situation. Desynchronization was associated with the recognition of sentences describing the children's own choice; synchronization was recorded when recognizing sentences describing the forced-choice situation.
Six species of four calcareous nannofossil genera (Ellipsagelosphaera Noël,1965, Watznaueria Reinhardt, 1964, Cyclagelosphaera Noël, 1965 and Tetralithus Gardet, 1955) from the black shale Bazhenov Formation of the West Siberian marine basin are described in layers, transitional from the Upper Jurassic (the Volgian-Tithonian Stage) to the Lower Cretaceous (the Berriasian Stage).Stratigraphically, the presence of the species of all genera in the Bazhenov Formation corresponds to the world data.Three new species (Ellipsagelosphaera bazhenovi Zanin sp.n., Watznaueria sp. and Tetralithus isopelxiros Zanin sp.n.have been determined.
In a previous study using one-step CRISPR/Cas9 genome editing in mouse zygotes, we created five founders carrying a 1,137 kb deletion and two founders carrying the same deletion, plus a 2,274 kb duplication involving the Cntn6 gene (encoding contactin-6). Using these mice, the present study had the following aims: ( i ) to establish stage of origin of these rearrangements; ( ii ) to determine the fate of the deleted DNA fragments; and ( iii ) to estimate the scale of unpredicted DNA changes accompanying the rearrangements. The present study demonstrated that all targeted deletions and duplications occurred at the one-cell stage and more often in one pronucleus only. FISH analysis revealed that there were no traces of the deleted DNA fragments either within chromosome 6 or on other chromosomes. These data were consistent with the Southern blot analysis showing that chromosomes with deletion often had close to expected sizes of removed DNA fragments. High-throughput DNA sequencing of two homozygotes for duplication demonstrated that there were no unexpected significant or scale DNA changes either at the gRNA and joint sites or other genome sites. Thus, our data suggested that CRISPR/Cas9 technology could generate megabase-sized deletions and duplications in mouse gametes at a reasonably specific level.
The genes ABCC8 and KCNJ11 have received intense focus in type 2 diabetes mellitus (T2DM) research over the past two decades. It has been hypothesized that the p.E23K (KCNJ11) mutation in the 11p15.1 region may play an important role in the development of T2DM. In 2009, Hamming et al. found that the p.1369A (ABCC8) variant may be a causal factor in the disease

therefore, in this study we performed a meta-analysis to evaluate the association between these single nucleotide polymorphisms (SNPs), including our original data on the Siberian population (1384 T2DM and 414 controls). We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. For p.S1369A, a meta-analysis was conducted on a total of 10 studies with a total sample size of 14,136

We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r2= 0.5633). In addition, the haplotype rs757110[T]-rs5219[C] (p.23K/p.S1369) was associated with T2DM (OR = 1.52, 95% CI: 1.04-2.24). The total OR was 1.14 (95% CI: 1.11-1.17) for p.E23K for a total sample size of 137,298. For p.S1369A, pooled OR of 1.14 [95% CI (1.08-1.19); p = 2 x 10-6]. Our calculations identified causal genetic variation within the ABCC8/KCNJ11 region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. Moreover, the OR value was not dependent on the frequency of p.E23K or p.S1369A in the populations.
Multiple scattering effects of electrons on carbon targets have been studied with high-resolution silicon microstrip detectors of the UA9 apparatus at the H8 line at CERN

Comparison of the scattering angle between data and GEANT4 simulation

shows excellent agreement in the core of the distributions leaving some residual disagreement in the tails
We present a search for a non-Standard-Model invisible particle X0 in the mass range 0.1–1.8 GeV/c2 in B+→e+X0 and B+→μ+X0 decays. The results are obtained from a 711 fb−1 data sample that corresponds to 772×106BB¯ pairs, collected at the ϒ(4S) resonance with the Belle detector at the KEKB e+e− collider. One B meson is fully reconstructed in a hadronic mode to determine the momentum of the lepton of the signal decay in the rest frame of the recoiling partner B meson. We find no evidence of a signal and set upper limits on the order of 10−6.Received 17 May 2016DOI:https://doi.org/10.1103/PhysRevD.94.012003© 2016 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasLeptonic, semileptonic & radiative decaysPhysical SystemsBottom mesonsHypothetical scalarsParticles & Fields
The oxidation process of samariumoxysulfide was studied in the temperature range of 500–1000 °C.

Our DTA investigation allowed for establishing the main thermodynamic (∆Hºexp = −654.6 kJ/mol) and kinetic characteristics of the process (Ea = 244 kJ/mol, A = 2 × 1010). The enthalpy value of samarium oxysulfate (ΔHºf (Sm2O2SO4(monocl)) = −2294.0 kJ/mol) formation was calculated. The calculated process enthalpy value coincides with the value determined in the experiment. It was established that samarium oxysulfate crystallizes in the monoclinic symmetry class and its crystal structure belongs to space group C2/c with unit cell parameters a = 13.7442 (2), b = 4.20178 (4) and c = 8.16711 (8)Å, β = 107.224 (1)°, V = 450.498 (9)Å3, Z = 4. The main elements of the crystalline structure are obtained and the cation coordination environment is analyzed in detail. Vibrational spectroscopy methods confirmed the structural model adequacy.

The Sm2O2SO4luminescence spectra exhibit three main bands easily assignable to the transitions from 4G5/2 state to 6H5/2, 6H7/2, and 6H9/2 multiplets.
With recent advances in robotics, various methods and systems for robotic movement planning have gained popularity. In particular, the problem of planning of pick and move operations for the robotic sorting cells has drawn certain attention because new strategies and algorithms become a necessity as a robotic sorting systems application area extends.

In the present work, a new algorithm for optimization of sorting operation sequences is proposed and results of its testing on a computer simulation are presented. The algorithm is based on the state tree search method and is aimed for performance improvement of the systems in which the input load can exceed the capacity of the robotic manipulator.
Record high differential efficiency (53.2%) and full optical efficiency (48%) for a multimode diode-pumped Yb:KYW laser have been achieved. The characteristics of the laser and methods for improving its efficiency using a distributed Bragg reflector tapered diode laser (DBR TDL) are discussed.
The methods which are used to combat pathogens of crops, in particular, chemical treatment, pose a threat to environmental safety. RNA interference could be one of the best ways to selectively control pests, but there are not enough methods for introducing dsRNA into plants without creating GMOs. The development of new methods of dsRNA delivery requires affordable and fast gene model systems, the purpose of which is our work. We selected the genes of several carbonic anhydrases functioning in the thylakoids and mitochondria of the whole plant, the suppression of which will be seen phenotypically based on the data on mutants for these genes. Specific primers have been designed, and a PCR reaction has also been carried out to obtain the product of the corresponding mRNA, which will be delivered to the plant in the future using the VIGS system.
Higher harmonic internal waves are generated at wave intersections and critical points of oscillating bodies, with higher amplitudes at steeper slopes and amplitude increase due to focusing for axisymmetric bodies.

The horizontal structure of the $n$th harmonic corresponds to multipole order ${2}^{n}$.
Applicability of the polymerase chain reaction (PCR) with species-specific primers to obtaining molecular markers for identification of the sibling species of Chironomus plumosus group - C. plumosus and C. balatonicus - has been estimated. The nucleotide sequences of internal transcribed spacer (ITS) from the locus encoding ribosomal RNA (rRNA) were used as the source for designing the species-specific primers. The primers allowing for identification of C. plumosus and C. balatonicus were constructed. One primer pair (plu107F/plu363R) gives the PCR product MAR2, specific of C. plumosus, and the other (bal86F/plu363R), the PCR product MAR6, specific of C. balatonicus. The testing involving 18 species of the genus Chironomus confirmed the specificity of the primers. The results suggest that the PCR with species-specific primers is promising for construction of molecular markers for identification not only of these two, but also of other Chironomus species.doi: 10.5324/fn.v31i0.1381.Published online: 17 October 2012.
There are currently over a thousand indigenous cattle breeds well adapted to local habitat conditions thanks to their long history of evolution and breeding. Identification of the genetic variations controlling the adaptation of local cattle breeds for their further introduction into the genome of highly productive global breeds is a matter of great relevance. Studying individual populations of the same breed with the use of microsatellite markers makes it possible to assess their genetic diversity, relationships, and breed improvement potential. Although the Black Pied breed is the most common dairy cattle breed in Russia, there are only a few studies on genetic diversity in local Black Pied populations in some Russian regions.

DNA samples from 4788 animals of the Black Pied breed from six breeding enterprises in the Novosibirsk Region have been studied using 11 microsatellite markers. The population distribution test, principal component analysis, FST and DEST values, cluster analysis, and phylogenetic analysis have been used.

No significant differences in genetic variability parameters were found between individual populations. Private alleles have been identified in five out of six populations. Five populations have shown inbreeding coefficient values (FIS) below zero, which indicates heterozygosity excess. Two populations genetically distinct from the others were revealed. Essentially, the genetic diversity parameters of the six studied Black Pied cattle populations from the Novosibirsk Region show no significant differences from other Russian populations of the breed. Excess heterozygosity is observed in most breeding enterprises, which is a sign of a low inbreeding rate. To maintain the genetic diversity of the Russian Black Pied cattle, we recommend focusing on the two populations with significant genetic distinctions from the others.
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,324 new measurements from 878 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons.

We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics.

The Review is divided into two volumes. Volume 1 includes the Summary Tables and 98 review articles. Volume 2 consists of the Particle Listings and contains also 22 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal.
We report on Large-eddy simulations (LES) of a flow around a cylinder in a narrow duct channel (slot) at the Reynolds number 3750 based on the bulk velocity and the diameter of the cylinder.

Secondary streamwise vortical structures in the far wake are investigated appearing near the mixing layer at the midplane and near the duct channel surface.

We investigate the correlation between the heat flux and friction velocity fluctuations and evaluate the propagation speed of these disturbances, which appears to be different.
Magnetotransport in submicron devices formed on the basis of GaAs/AlGaAs structures is simulated by the method of nonequilibrium Green functions. In the one-particle approximation, the influence of a perpendicular magnetic field on electron transmission through a quasi-one-dimensional quantum dot and the Aharonov—Bohm interferometer is considered. Two-terminal conductance and magnetic moment of the devices are calculated. Two-dimensional patterns of equilibrium (persistent) currents are obtained. The correlations between energy dependences of magnetic moment and conductance are considered. For the quasi-one-dimensional quantum dot, regular conductance oscillations similar to the ABOs were found at low magnetic fields (0.05—0.4 T). In the case of a ring interferometer, the contribution to the total equilibrium current and magnetic moment at a given energy can change sharply both in magnitude and in sign when the magnetic field changes within the same Aharonov—Bohm oscillation. The conductance through the interferometer is determined not by the number of propagating modes, but rather by the influence of triangular quantum dots at the entrances to the ring, causing back scattering. Period of calculated ABOs corresponds to that measured for these devices.
Hydrolytic equilibria of Tm (III) in KOH solutions were studied at 25°C. A spectrophotometry with m-cresol purple and 2-naphthol as pH indicators was used at an ionic strength of not more than 0.0005. The results indicate that in freshly prepared solutions at pH ranging between 6 and 10 Tm is present as , , and . The stepwise stability constants of hydroxide complexes calculated at zero ionic strength were obtained as coefficient of linear regression equations from the graph of optical densities of the indicators in Tm solutions at varying pH.