Hengzongshu/ArticleAgent huggingface dataset:
Peptides containing arginine and capable of delivering it into cells can be considered as a source of nitric oxide synthase (NOS) substrate for increasing NO synthesis. NO, in turn, is a key antithrombotic and anti-atherosclerotic factor. Thus, preparations based on biodegradable arginine-containing polymers are a promising direction in the treatment of hemocirculation disorders.

Here we showed a synthetic approach to make a new peptide-like biodegradable polymer with specific metabolic-related properties. Its ability to increase NO production in vitro and vasodilator action in vivo was evaluated. The backbone structure of the proposed polymer is a sequence of cysteines polymerized into linear or cyclic molecules through disulfide bridges and diamine spacers; L-arginine residues are grafted onto the main chain via peptide bonds. Consequently, the structure bears a set of properties of cell-penetrating peptides (CPP), which provides the ability to move across the cell membrane and indirectly increase the bioavailability of arginine. The proposed polymeric molecules are stable in oxidative media but could be easily depolymerized in a reducing intracellular environment with the formation of thiol-containing monomers, prone to intracellular enzymatic hydrolysis yielding amino acids (arginine and cysteine).

In vitro experiments have shown a significant increase in NO production compared to octa-arginine (reference) and monomeric arginine (control). In vivo study has shown a significant decrease in blood pressure compared to intact controls. As a result, a peptide-like L-arginine grafted polymeric structure demonstrating CPP-properties can be considered a promising compound for creating vasoactive drugs.
Calculation results for the forms in which chemical elements migrate in the thermal waters of the Bang deposit (Central Vietnam) are reported for the first time. The studied waters are divided into two groups with respect to temperature: 24.3–34.5 оС for the first group and 62.1–97.1 оC for the second group. The first type relates to the waters of HCO3-Cl-Na-Mg composition, has very low mineralization (44–87 mg/dm3) and is characterized by рН from weakly acidic to weakly alkaline (5.71-7.84). The second type relates to the waters of HCO3-Na composition with total mineralization up to 256-659 mg/dm3 and рН from 8.03 to 8.51. Calculations of the forms of migration of chemical elements showed substantial differences in their behavior for two revealed groups. For example, in waters with the temperature of 24.3–34.5 оC, the dominating form is migration of free ions. For thermal waters with the temperature of 62.1–97.1 оC, migration of the elements in compounds with carbonates and sulfur is characteristic, as well as in the form of free ions.
We report results of a study of doubly charmed baryons and charmed strange baryons. The analysis is performed using a $980\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ data sample collected with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider. We search for doubly charmed baryons ${\mathrm{\ensuremath{\Xi}}}_{cc}^{+(+)}$ with the ${\mathrm{\ensuremath{\Lambda}}}_{c}^{+}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}({\ensuremath{\pi}}^{+})$ and ${\mathrm{\ensuremath{\Xi}}}_{c}^{0}{\ensuremath{\pi}}^{+}({\ensuremath{\pi}}^{+})$ final states. No significant signal is observed. We also search for two excited charmed strange baryons, ${\mathrm{\ensuremath{\Xi}}}_{c}(3055{)}^{+}$ and ${\mathrm{\ensuremath{\Xi}}}_{c}(3123{)}^{+}$ with the ${\mathrm{\ensuremath{\Sigma}}}_{c}^{++}(2455){K}^{\ensuremath{-}}$ and ${\mathrm{\ensuremath{\Sigma}}}_{c}^{++}(2520){K}^{\ensuremath{-}}$ final states. The ${\mathrm{\ensuremath{\Xi}}}_{c}(3055{)}^{+}$ signal is observed with a significance of 6.6 standard deviations including systematic uncertainty, while no signature of the ${\mathrm{\ensuremath{\Xi}}}_{c}(3123{)}^{+}$ is seen. We also study properties of the ${\mathrm{\ensuremath{\Xi}}}_{c}(2645{)}^{+}$ and measure a width of $2.6\ifmmode\pm\else\textpm\fi{}0.2(\text{stat})\ifmmode\pm\else\textpm\fi{}0.4(\text{syst})\text{ }\text{ }\mathrm{MeV}/{c}^{2}$, which is the first significant determination.
Based on the analysis of research literature, the author comes to the conclusion that there is a local, ethnic nature of the specificity of scientific communities.

The obtained theoretical results are illustrated by the example of the formation, evolution and current state of the scientific and educational communities of the republics of Siberia (Tuva, Khakassia, Buryatia, Altai).

It is proved that the specifics of their post-Soviet development is largely due to Soviet experience, in particular when it comes to the place of a scientist in a traditional and modernized society, the role of science and education as a social elevator, the place of spheres of intellectual production in the modern social and economic structure of these regions.
We present the numerical study of the statistical properties of the partially coherent quasi-CW high-Q cavity Raman fiber laser. The statistical properties are different for the radiation generated at one or many cavity passes. It is found that rare extreme events are generated at the far spectral wings of the spectrum. The mechanism of the extreme events generation is a turbulent-like four-wave mixing of numerous longitudinal generation modes.
A large number of model particles is shown necessary for quantitatively correct simulations of the kinetic beam-plasma instability with the clouds-in-cells method. The required number of particles scales inversely with the expected growth rate, as in the kinetic regime only a narrow interval of beam velocities is resonant with the wave.
The relationship between compartmentalization of the genome and epigenetics is long and hoary. In 1928, Heitz defined heterochromatin as the largest differentiated chromatin compartment in eukaryotic nuclei. Müller's discovery of position-effect variegation in 1930 went on to show that heterochromatin is a cytologically visible state of heritable (epigenetic) gene repression. Current insights into compartmentalization have come from a high-throughput top-down approach where contact frequency (Hi-C) maps revealed the presence of compartmental domains that segregate the genome into heterochromatin and euchromatin. It has been argued that the compartmentalization seen in Hi-C maps is owing to the physiochemical process of phase separation. Oddly, the insights provided by these experimental and conceptual advances have remained largely silent on how Hi-C maps and phase separation relate to epigenetics. Addressing this issue directly in mammals, we have made use of a bottom-up approach starting with the hallmarks of constitutive heterochromatin, heterochromatin protein 1 (HP1) and its binding partner the H3K9me2/3 determinant of the histone code. They are key epigenetic regulators in eukaryotes. Both hallmarks are also found outside mammalian constitutive heterochromatin as constituents of larger (0.1–5 Mb) heterochromatin -like domains and smaller (less than 100 kb) complexes. The well-documented ability of HP1 proteins to function as bridges between H3K9me2/3-marked nucleosomes contributes to polymer–polymer phase separation that packages epigenetically heritable chromatin states during interphase. Contacts mediated by HP1 ‘bridging’ are likely to have been detected in Hi-C maps, as evidenced by the B4 heterochromatic subcompartment that emerges from contacts between large KRAB-ZNF heterochromatin -like domains. Further, mutational analyses have revealed a finer, innate, compartmentalization in Hi-C experiments that probably reflect contacts involving smaller domains/complexes. Proteins that bridge (modified) DNA and histones in nucleosomal fibres—where the HP1–H3K9me2/3 interaction represents the most evolutionarily conserved paradigm—could drive and generate the fundamental compartmentalization of the interphase nucleus. This has implications for the mechanism(s) that maintains cellular identity, be it a terminally differentiated fibroblast or a pluripotent embryonic stem cell.
An exact analytical theory is developed for calculating the diffusion coefficient of charge carriers in strongly anisotropic disordered solids with one-dimensional hopping transport mode for any dependence of the hopping rates on space and energy. So far, such a theory existed only for calculating the carrier mobility. The dependence of the diffusion coefficient on the electric field evidences a linear, nonanalytic behavior at low fields for all considered models of disorder. The mobility, on the contrary, demonstrates a parabolic, analytic field dependence for a random-barrier model, being linear, nonanalytic for a random-energy model. For both models, the Einstein relation between the diffusion coefficient and mobility is proven to be violated at any finite electric field. The question on whether these nonanalytic field dependences of the transport coefficients and the concomitant violation of the Einstein's formula are due to the dimensionality of space or due to the considered models of disorder is resolved in the following paper [], where analytical calculations and computer simulations are carried out for two- and three-dimensional systems.
Wireless sensor networks are used to monitor air pollution, water pollution, and machine health; in forest fire and landslide detection; and in natural disaster prevention. Sensors in wireless sensor networks are often battery-powered and disposable, so one may be interested in lowering the energy consumption of the sensors in order to achieve a long lifetime of the network. We study the min-power symmetric connectivity problem, which models the task of assigning transmission powers to sensors so as to achieve a connected communication network with minimum total power consumption. The problem is known to be NP-hard.

We provide perhaps the first parameterized complexity study of optimal and approximate solutions for the problem. Our algorithms work in polynomial time in the scenario where one has to reconnect a sensor network with n sensors and O(log n)-connected components by means of a minimum transmission power increase or if one can find transmission power lower bounds that already yield a network with O(log n)-connected components. In experiments, the algorithm outperforms CPLEX with known integer linear programming (ILP) formulations when n is sufficiently large compared with c.

Strengthening this hardness result, we show that even o(log n)-approximating the difference d between the optimal solution cost and a natural lower bound is NP-hard. Moreover, we show that under the exponential time hypothesis, there are no exact algorithms running in 2 o(n) time or in [Formula: see text] time for any computable function f. We also show that the special case of connecting c network components with minimum additional cost generally cannot be polynomial-time reduced to instances of size c O(1) unless the polynomial-time hierarchy collapses. On the positive side, we provide an algorithm that reconnects O(log n)-connected components with minimum additional cost in polynomial time.
. The results of three series of rocket measurements of mesospheric electric fields carried out under different geomagnetic conditions at polar and high middle latitudes are analysed. The measurements show a clear dependence of the vertical electric fields on geomagnetic activity at polar and high middle latitudes. The vertical electric fields in the lower mesosphere increase with the increase of geomagnetic indexes Kp and ∑Kp. The simultaneous increase of the vertical electric field strength and ion conductivity was observed in the mesosphere during geomagnetic disturbances. This striking phenomenon was displayed most clearly during the solar proton events of October, 1989 accompanied by very strong geomagnetic storm (Kp=8+). A possible mechanism of generation of the vertical electric fields in the mesosphere caused by gravitational sedimentation of charged aerosol particles is discussed. Simultaneous existence in the mesosphere of both the negative and positive multiply charged aerosol particles of different sizes is assumed for explanation of the observed V/m vertical electric fields and their behaviour under geomagnetically disturbed conditions.Keywords. Atmospheric composition and structure (aerosols and particles) · Ionosphere (electric fields and currents) · Meteorology and atmospheric dynamics (atmospheric electricity)
This paper presents the results of comparative experiments on the excitation of inductively coupled plasma in water vapor in cylindrical and toroidal discharge chambers having the same outer diameter. The plasma temperature in the cylindrical and toroidal chambers was determined using the Boltzmann plot method. With equal discharge power and pressure, the temperature in the toroidal chamber was found to be higher than that in the cylindrical chamber. This is attributed to the lower heat transfer and the absence of a near-axial layer in the toroidal chamber as compared with cylindrical geometry.
We report the observation of two narrow structures in the mass spectra of the pi+-Y(nS) (n=1,2,3) and pi+-hb(mP)(m$ (m=1,2) pairs that are produced in association with a single charged pion in Y(5S) decays.

The results are obtained with a 121.4 1/fb data sample collected with the Belle detector in the vicinity of the Y(5S) resonance at the KEKB asymmetric-energy e+e- collider.

The measured masses and widths of the two structures averaged over the five final states are M_1=(10607.2+-2.0) MeV/c2, Gamma_1=(18.4+-2.4) MeV and M_2=(10652.2+-1.5) MeV/c2, Gamma_2=(11.5+-2.2) MeV.
The device performance of organic thin-film transistors (OTFTs) employing the solution processed films of room temperature liquid-crystalline tetrasubstituted zinc phthalocyanine derivative was found to depend upon the film morphology. Atomic force microscopic and X-Ray diffraction studies show that the annealing at produced a preferentially unidirectional void-free film with improved surface smoothness. The OTFTs with the annealed films exhibited enhanced conductivity, threefold reduction in threshold voltage, a nearly one order of magnitude increase in the on/off ratio and more than one-third reduction of hysteresis in the transfer characteristics.
The analysis of the observational data for the secular perihelion precession of Mercury, Earth, and Mars, based on the EPM2004 ephemerides, results in new upper limits on density of dark matter in the solar system.
The aim of this study is to investigate the 14-year risk of type 2 diabetes mellitus (T2DM) and develop a risk score for T2DM in the Siberian cohort. A random population sample (males/females, 45-69 years old) was examined at baseline in 2003-2005 (Health, Alcohol, and Psychosocial Factors in Eastern Europe (HAPIEE) project, n = 9360, Novosibirsk) and re-examined in 2006-2008 and 2015-2017. After excluding those with baseline T2DM, the final analysis included 7739 participants. The risk of incident T2DM during a 14-year follow-up was analysed using Cox regression. In age-adjusted models, male and female hazard ratios (HR) of incident T2DM were 5.02 (95% CI 3.62; 6.96) and 5.13 (95% CI 3.56; 7.37) for BMI ≥ 25 kg/m2; 4.38 (3.37; 5.69) and 4.70 (0.27; 6.75) for abdominal obesity (AO); 3.31 (2.65; 4.14) and 3.61 (3.06; 4.27) for fasting hyperglycaemia (FHG); 2.34 (1.58; 3.49) and 3.27 (2.50; 4.26) for high triglyceride (TG); 2.25 (1.74; 2.91) and 2.82 (2.27; 3.49) for hypertension (HT); and 1.57 (1.14; 2.16) and 1.69 (1.38; 2.07) for family history of diabetes mellitus (DM). In addition, secondary education, low physical activity (PA), and history of cardiovascular disease (CVD) were also significantly associated with T2DM in females. A simple T2DM risk calculator was generated based on non-laboratory parameters. A scale with the best quality included waist circumference >95 cm, HT history, and family history of T2DM (area under the curve (AUC) = 0.71). The proposed 10-year risk score of T2DM represents a simple, non-invasive, and reliable tool for identifying individuals at a high risk of future T2DM.
Denote by $\nu_p(G)$ the number of Sylow $p$-subgroups of $G$. It is not difficult to see that $\nu_p(H)\leq\nu_p(G)$ for $H\leq G$, however $\nu_p(H)$ does not divide $\nu_p(G)$ in general.

In this paper we reduce the question whether $\nu_p(H)$ divides $\nu_p(G)$ for every $H\leq G$ to almost simple groups.

This result substantially generalizes the previous result by G. Navarro and also provides an alternative proof for the Navarro theorem.
Background: There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety.

The study aimed to analyze mRNA levels of the serotonergic genes in the raphe nuclei of the midbrain that may be associated with chronic social defeats consistently shown by male mice in special experimental settings. The serotonergic genes were the Tph2, Sert, Maoa and Htr1a. The Bdnf, Creb, Cphn, Gapdh, Hprt, B2M, 18S and Actb genes were also studied. The experimental groups were composed of male mice with experience of defeats in 21 daily encounters and male mice with the same track record of defeats followed by a no-defeat period without agonistic interactions (relative rest for 14 days).

CSDS experience inducing the development of mixed anxious/depression-like state in male mice down-regulates the serotonergic genes expression associated with the synthesis, inactivation and reception of serotonin. The Bdnf and Creb genes as well as the cell and metabolic Cphn, Gapdh, Hprt, B2M, Actb and 18S genes in the midbrain raphe nuclei are also down-regulated under CSDS. Period of relative rest is not enough for most genes to recover expression to the control levels.
We review methods for coherently controlling Rydberg quantum states of atomic ensembles using Adiabatic Rapid Passage and Stimulated Raman Adiabatic Passage. These methods are commonly used for population inversion in simple two-level and three-level systems. We show that adiabatic techniques allow us to control population and phase dynamics of complex entangled states of mesoscopic atomic ensembles for quantum information processing with Rydberg atoms. We also propose several schemes of single-qubit and two-qubit gates based on adiabatic passage, Rydberg blockade and F\"{o}rster resonances in Rydberg atoms.
We perform Large-eddy simulations of an annular swirling turbulent jet for S = 0, S = 0.3 and S = 1, where S is swirl number. The Reynolds number based on the bulk velocity in the feeding channel and the outer diameter was 8900. The analysis showed that the region around the stagnation point in the end of the recirculation zone has a high level of turbulent kinetic energy. The length of the recirculation zone decreases in case for low swirl (S = 0.3) compared to the non-rotating case, while for the higher rotation rate (S = 1) the recirculation bubble becomes enormously long. Spectral analysis showed two peaks corresponding to the Kelvin-Helmholtz instability and some low-frequency oscillations of the recirculating zone.
Fibre lasers have been shown to manifest a laminar-to-turbulent transition when increasing its pump power. In order to study the dynamical complexity of this transition we use advanced statistical tools of time-series analysis. We apply ordinal analysis and the horizontal visibility graph to the experimentally measured laser output intensity. This reveal the presence of temporal correlations during the transition from the laminar to the turbulent lasing regimes. Both methods allow us to unveil coherent structures with well defined time-scales and strong correlations both, in the timing of the laser pulses and in their peak intensities.
Los ejemplares de Dickinsonia de los Urales Centrales se caracterizan por una clara simetría bilateral. Tomando en cuenta las observaciones de especímenes australianos, consideramos que la llamada’simetría de reflexión por deslizamiento’ en estos fósiles es un fenómeno tafonómico. El gráfico de distribución de frecuencias de tamaño muestra el predominio de individuos juveniles en la población estudiada de Dickinsonia de los Urales Centrales. Asumiendo que la edad de un individuo se manifiesta por su tamaño, existe un predominio significativo de individuos juveniles en la población. Se pueden prever tres escenarios posibles: (1) la población tiene un gran número de individuos juveniles como resultado de la alta tasa de supervivencia en la zona intermareal; (2) la población está dominada por formas juveniles porque está enterrada inmediatamente después de la eclosión; (3) suponiendo que Dickinsonia fuera un organismo móvil activo, la abundancia de individuos juveniles podría explicarse por su incapacidad para escapar del entierramiento (aunque es difícil imaginar que algunos de los individuos maduros estén enterrados con signos de comportamiento de escape); y (4) la población podría interpretarse como un “lugar de nidificación” fosilizado para Dickinsonia en la zona intermareal, donde las formas juveniles maduraron antes de migrar a la zona submareal. La población de estudio puede caracterizarse como en expansión o estable; por lo tanto, el entorno intermareal puede describirse como favorable para estos organismos
Random transgene integration is a powerful tool for developing new genome-wide screening approaches. These techniques have already been used for functional gene annotation by transposon-insertion sequencing, for identification of transcription factor binding sites and regulatory sequences, and for dissecting chromatin position effects. Precise localization of transgenes and accurate artifact filtration are essential for this type of method. To date, many mapping assays have been developed, including Inverse-PCR, TLA, LAM-PCR, and splinkerette PCR. However, none of them is able to ensure localization of both transgene's flanking regions simultaneously, which would be necessary for some applications.

Here we proposed a cheap and simple NGS-based approach that overcomes this limitation. The developed assay requires using intentionally designed vectors that lack recognition sites of one or a set of restriction enzymes used for DNA fragmentation. By looping and sequencing these DNA fragments, we obtain special data that allows us to link the two flanking regions of the transposon.

This can be useful for precise insertion mapping and for screening approaches in the field of chromosome engineering, where chromosomal recombination events between transgenes occur in a cell population. To demonstrate the method's feasibility, we applied it for mapping SB transposon integration in the human HAP1 cell line. Our technique allowed us to efficiently localize genomic transposon integrations, which was confirmed via PCR analysis. For practical application of this approach, we proposed a set of recommendations and a normalization strategy. The developed method can be used for multiplex transgene localization and detection of rearrangements between them.
An extension of the well known ee → 4 l event generator of F. A. Berends, P. H. Daverveldt, and R. Kleiss is presented.

This extension accounts for production of narrow resonances, as well as the initial state radiation.

In addition, it allows one to simulate the production of l + l − π + π − with the lepton pair and the pion pair in 1 −− states.