Hengzongshu/ArticleAgent huggingface dataset:
The phytohormone salicylic acid (SA) is well known for its induction of pathogenesis-related proteins and systemic acquired resistance; SA also has specific effects on plant growth and development. Here we analyzed the effect of SA on Arabidopsis (Arabidopsis thaliana) root development. We show that exogenous SA treatment at low (below 50 µM) and high (greater than 50 µM) concentrations affect root meristem development in two different PR1-independent ways. Low-concentration SA promoted adventitious roots and altered architecture of the root apical meristem, whereas high-concentration SA inhibited all growth processes in the root. All exposures to exogenous SA led to changes in auxin synthesis and transport. A wide range of SA treatment concentrations activated auxin synthesis, but the effect of SA on auxin transport was dose dependent. Mathematical modeling of auxin synthesis and transport predicted auxin accumulation or depletion in the root tip following low- or high-concentration SA treatments, respectively. SA-induced auxin accumulation led to the formation of more layers of columella initials, an additional cortical cell layer (middle cortex), and extra files of epidermis, cortex, and endodermis cells. Suppression of SHORT ROOT and activation of CYCLIN D6;1 mediated the changes in radial architecture of the root. We propose that low-concentration SA plays an important role in shaping root meristem structure and root system architecture.
Duplications and deletions in the human genome Duplications and deletions can lead to variation in copy number for genes and genomic loci among humans. Such variants can reveal evolutionary patterns and have implications for human health.

Sudmant et al. examined copy-number variation across 236 individual genomes from 125 human populations.

Deletions were under more selection, whereas duplications showed more population-specific structure. Interestingly, Oceanic populations retain large duplications postulated to have originated in an ancient Denisovan lineage.
We report on a search for heavy neutrinos in B-meson decays. The results are obtained using a data sample that contains 772x10^6 BB-bar pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. No signal is observed and upper limits are set on mixing of heavy neutrinos with left-handed neutrinos of the Standard Model in the mass range 0.5 - 5.0 GeV/c^2.
High-fidelity entangled Bell states are of great interest in quantum physics. Entanglement of ultracold neutral atoms in two spatially separated optical dipole traps is promising for implementation of quantum computing and quantum simulation and for investigation of Bell states of material objects.

We propose a new method to entangle two atoms via long-range Rydberg-Rydberg interaction. Alternatively to previous approaches, based on Rydberg blockade, we consider radiofrequency-assisted Stark-tuned F"{o}rster resonances in Rb Rydberg atoms. To reduce the sensitivity of the fidelity of Bell states to the fluctuations of interatomic distance, we propose to use the double adiabatic passage across the radiofrequency-assisted Stark-tuned F"{o}rster resonances,

which results in a deterministic phase shift of the two-atom state.
A low-temperature intervening metallic regime arising in the two-dimensional superconductor-insulator transition challenges our understanding of electronic fluids.

Here we develop a gauge theory revealing that this emergent anomalous metal is a bosonic topological insulator where bulk transport is suppressed by mutual statistics interactions between out-of-condensate Cooper pairs and vortices and the longitudinal conductivity is mediated by symmetry-protected gapless edge modes. We explore the magnetic-field-driven superconductor-insulator transition in a niobium titanium nitride device and find marked signatures of a bosonic topological insulator behavior of the intervening regime with the saturating resistance.

The observed superconductor-anomalous metal and insulator-anomalous metal dual phase transitions exhibit quantum Berezinskii-Kosterlitz-Thouless criticality in accord with the gauge theory.
We consider the simulation of scattering of the high-order vector Bessel beams in the discrete dipole approximation framework (DDA).

For this purpose, a new general classification of all existing Bessel beam types was developed based on the superposition of transverse Hertz vector potentials. Next, we implemented these beams in ADDA code – an open-source parallel implementation of the DDA.

The code enables easy and efficient simulation of Bessel beams scattering by arbitrary-shaped particles. Moreover, these results pave the way for the following research related to the Bessel beam scattering near a substrate and optical forces.
The work is devoted to the development of an application for monitoring and controlling the state of equipment (extruder) for the petrochemical industry based on sensor readings using a machine learning model.

The statistical relationships of the technological process parameters are analyzed, the most significant parameters influencing the occurrence of failures are determined using SHAP values. The hypotheses regarding the effectiveness of various machine learning algorithms in relation to the real problem of predicting the technical state of the extruder are tested. A gradient boosting model has been developed to predict the probability of extruder shutdown due to the formation of polypropylene agglomerates.

The developed application allows interpreting the results of the model, which makes it possible to select the most important process parameters that have the greatest impact on the probability of extruder failure, and also proposing a prototype of an extruder monitoring system based on sensor readings using a machine learning model.
We consider the equations of a multi-velocity model of a binary mixture of viscous compressible fluids (two-fluid medium) in the case of one-dimensional barotropic motions. We prove the global (in time) existence and uniqueness of a strong solution to the initial-boundary value problem describing the motion in a bounded spatial domain.
There has been a comparison made for the results achieved in this study and results of other authors who used finite difference and spectral methods.

This paper reports new h-and p-versions of the least squares collocation method of high-order accuracy proposed and implemented for solving boundary value problems for the biharmonic equation in irregular and multiply-connected domains.

This paper shows that approximate solutions obtained by the least squares collocation method converge with high order and agree with analytical solutions of test problems with high degree of accuracy.
Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cellular pathway responsible for repair of these lesions, and as deficiency in BER activity results in DNA damage it has been proposed that it may trigger the development of sporadic cancers. Nevertheless, experimental evidence for this model remains inconsistent and elusive. Here, we performed a proteomic analysis of BER deficient human cells using stable isotope labelling with amino acids in cell culture (SILAC), and demonstrate that BER deficiency, which induces genetic instability, results in dramatic changes in gene expression, resembling changes found in many cancers. We observed profound alterations in tissue homeostasis, serine biosynthesis, and one-carbon- and amino acid metabolism, all of which have been identified as cancer cell 'hallmarks'. For the first time, this study describes gene expression changes characteristic for cells deficient in repair of endogenous DNA lesions by BER. These expression changes resemble those observed in cancer cells, suggesting that genetically unstable BER deficient cells may be a source of pre-cancerous cells.
Solid solutions La0.5Ca0.5Mn1-xFexO3 synthesized by the method of polymer-salt compositions at a temperature of 900 °C with the perovskite structure were tested in the methane oxidation reaction.

The formation of planar defects in the direction of crystallographic planes (101) in the perovskite structure at the stage of the synthesis of solid solutions and the appearance of nanoparticles of Ca-Mn oxides on the surface of perovskite after participation after reaction were shown by the HRTEM method.

It was shown that at 600 °C, complete conversion of methane occurs for all compositions, however, the nature of the dependence of the degree of conversion for lower temperatures is not linear and depends on the chemical composition.
The external drosophila mechanoreceptors, residing on the head and body of imago, are represented by bristles of diﬀerent sizes (macrochaetes and microchaetes). Macrochaetes are arranged in the species-specifc bristle pattern, where each of them is strictly positioned. The bristle pattern is formed starting from its prototype (prepattern) in the imaginal disc. The position specifcity of future mechanoreceptors is determined by local expression of two proneural genes, achaete ( ac ) and scute ( sc ) belonging to the AS-C complex, in response to the action of certain factors, referred to as prepattern factors, nonuniformly distributed in the ectoderm of imaginal discs. The topography of their total distribution defnes the bristle prepattern. Thus, the full-ﬂedged adult bristle pattern is the result of interaction of two systems – the prepattern and the system responding to prepattern, i. e., the achaete and scute genes. A considerable volume of miscellaneous experimental data related to various aspects in development of the bristle pattern has been so far accumulated; however, any formalized and detailed representation of the molecular genetic interaction of the prepattern factors with both each other and the achaete-scute genes is yet absent. This review systematizes the available data on the regular patterns of this interaction and shows that local expression of these genes is determined by hierarchical two-level control system comprising both direct and indirect regulators of their activities. A generalized scheme of the system containing the functional interactions of its components is proposed. The structural organization and principles of operation of the hierarchical molecular genetic system enabling the local expression of ASC genes and the resulting formation of ordered bristle pattern are described.
Genome architecture plays a pivotal role in gene regulation. The use of high-throughput methods for chromatin profiling and 3-D interaction mapping provide rich experimental data sets describing genome organization and dynamics.

In this review, we describe how chromatin architecture could be reconstructed from epigenetic data using biophysical or statistical approaches. We discuss the applicability and limitations of these methods for understanding the mechanisms of chromatin organization.

We also highlight the emergence of new predictive approaches for scoring effects of structural variations in human cells.
Functional properties of this detector are based on the regularities of transmission of magnetized electrons through cylindrical channels drilled in absorbing material.

Simulations of motion, reflection and absorption of electrons in detector channels performed with code Geant4, have shown the possibility to measure an electron distribution function over their initial pitch-angles with angular resolution ∼0.05 rad.

Measurement results for electron angular distribution of the beam in the magnetic field 0.6 T that is generated by the accelerator U-2 are presented and discussed in the paper.
Numerical research results of deciduous tree ignition by cloud-to-ground lightning discharge are presented.

The problem is solved in one-dimensional statement in cylindrical system of coordinates. The typical range of influence parameters of positive and negative cloud-to-ground lightning discharges is considered.

Ignition conditions for deciduous tree are established.
Q-Band electron spin echo spectroscopy allows distinguishing light-induced polarons of different types in photovoltaic polymer/fullerene composites.
The effect of colchicine on phenotypic classes ratio of the enzyme locus controlling alcohol dehydrogenase (ADH1) in sugar beet agamospermous progenies was analysed.

Theoretical calculation of the formation of egg cells frequencies and those of further development of cells entering embryogenesis without fertilization, also the diminution calculation of excessive chromosome regions carrying marker locus alleles have been made.

The coincidence of theoretical and experimental ratios of phenotypic classes indicates the existence of post-meiotic apozygotic combinatory process in plants.
H3K9 methylation is known to play a critical role in gene silencing. This modification is established and maintained by several enzymes, but relationships between them are not fully understood.

In the present study, we decipher the interplay between two Drosophila H3K9-specific histone methyltransferases, SU(VAR)3-9 and SETDB1. We asked whether SETDB1 is required for targeting of SU(VAR)3-9. Using DamID-seq, we obtained SU(VAR)3-9 binding profiles for the chromosomes from larval salivary glands and germline cells from adult females, and compared profiles between the wild type and SETDB1-mutant backgrounds.

Our analyses indicate that the vast majority of single copy genes in euchromatin are targeted by SU(VAR)3-9 only in the presence of SETDB1, whereas SU(VAR)3-9 binding at repeated sequences in heterochromatin is largely SETDB1-independent. Interestingly, piRNA clusters 42AB and 38C in salivary gland chromosomes bind SU(VAR)3-9 regardless of SETDB1, whereas binding to the same regions in the germline cells is SETDB1-dependent. In addition, we compared SU(VAR)3-9 profiles in female germline cells at different developmental stages (germarium cells in juvenile ovaries and mature nurse cells). It turned out that SU(VAR)3-9 binding is influenced both by the presence of SETDB1, as well as by the differentiation stage.
The paper considers the possibilities of quality control of the conductive surface and detection of objects on it beyond the horizon, as well as microscopy of flat faces of semiconductor products using surface electromagnetic waves (SEWs) of the terahertz (THz) range. The conditions under which such methods of control can be implemented are determined; schemes of devices that implement such measurements are elaborated; estimates of the possibilities of the developed methods for monitoring metal and semiconductor products probed by monochromatic THz radiation in the form of SEWs are given.
Narrowband Raman lasing in a polarization-maintaining two-core fiber (TCF) is demonstrated. Femtosecond point-by-point inscription of fiber Bragg gratings (FBGs) in individual cores produces a half-open cavity with random distributed feedback. The laser linewidth in the cavity with a single FBG inscribed in one core of the TCF reduced by ∼2 times with respect to the cavity with a fiber loop mirror. It is shown that the inscription of two FBGs in different cores leads to the formation of a Michelson-type interferometer, leading to the modulation of generation spectra near threshold. This technique offers new possibilities for spectral filtering or multi-wavelength generation.
We report on recent results from the Belle detector related to studies of meson properties.

They include an observation of new mesons of light quarks in γγ collisions, a discovery of a new D state in the ψ family

and observations of new states in the bottomonium family.
McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS); nevertheless, it takes a considerable amount of time to make a clinical decision. Amino acid and fatty acid metabolic pathways are disturbed in MS, and this information could be useful for diagnosis. The aim of our study was to find changes in amino acid and acylcarnitine plasma profiles for distinguishing patients with multiple sclerosis from healthy controls. We have applied a targeted metabolomics approach based on tandem mass-spectrometric analysis of amino acids and acylcarnitines in dried plasma spots followed by multivariate statistical analysis for discovery of differences between MS (n=16) and control (n=12) groups. It was found that partial least square discriminant analysis yielded better group classification as compared to principal component linear discriminant analysis and the random forest algorithm. All the three models detected noticeable changes in the amino acid and acylcarnitine profiles in the MS group relative to the control group. Our results hold promise for further development of the clinical decision support system.
A theory describing experimental beam profiles of multimode fiber Raman lasers is developed

random mode coupling, Kerr self-cleaning and spatial filtering play a decisive role in shaping Stokes beams

whereas depleted pump beams remain insensitive
Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV.

The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins. Based on manual review and curation of scientific publications a catalog comprising 140 human genes involved in response to TBEV infection was developed. To provide access to data on all genes, the TBEVhostDB web resource ( http://icg.nsc.ru/TBEVHostDB/ ) was created. We reconstructed a network formed by pairwise interactions between TBEV virion itself, viral RNA and viral proteins and 140 genes/proteins from TBEVHostDB. Genes were ranked according to the number of interactions in the network.

Two genes/proteins (CCR5 and IFNAR1) that had maximal number of interactions were revealed. It was found that the subnetworks formed by CCR5 and IFNAR1 and their neighbors were a fragments of two key pathways functioning during the course of tick-borne encephalitis: (1) the attenuation of interferon-I signaling pathway by the TBEV NS5 protein that targeted peptidase D; (2) proinflammation and tissue damage pathway triggered by chemokine receptor CCR5 interacting with CD4, CCL3, CCL4, CCL2. Among nine genes associated with severe forms of TBEV infection, three genes/proteins (CCR5, IL10, ARID1B) were found to have protein-protein interactions within the network, and two genes/proteins (IFNL3 and the IL10, that was just mentioned) were up- or down-regulated in response to TBEV infection. Based on this finding, potential mechanisms for participation of CCR5, IL10, ARID1B, and IFNL3 in the host response to TBEV infection were suggested. A database comprising 140 human genes involved in response to TBEV infection was compiled and the TBEVHostDB web resource, providing access to all genes was created. This is the first effort of integrating and unifying data on genetic factors that may predispose to severe forms of diseases caused by TBEV. The TBEVHostDB could potentially be used for assessment of risk factors for severe forms of tick-borne encephalitis and for the design of personalized pharmacological strategies for the treatment of TBEV infection.
The current article deals with the dichotomy communication -transference with respect to the earlier opened dichotomy synchrony-diachrony.The new type of transference is discussed.It is based on the role of performatives as messages which cannot be denied by logics."Communication" and "transference" play a significant role in preserving non-genetic data.The transference is considered to be a cognitive process, which is aimed at storing information in generations.
We study Luzin N-property with respect to the Hausdorff measures for Sobolev spaces W^k_p(R^n,R^d).

We prove that such N-property holds except for one critical dimensional value t_*=n-(k-1)p; for this critical value the N-property fails in general, and we constructed the corresponding nontrivial counterexample (based on the theory of lacunary Fourier series). Nevertheless, this N-property holds if we assume in addition that the highest k-derivatives belongs to the Lorentz space L_{p,1} instead of L_p.

We extend these results to the case of fractional Sobolev spaces as well. Also, we establish some Fubini type theorems for $N$-properties and discuss their applications to the Morse--Sard theorem and its recent extensions.
Using model spontaneously reverting cell lines, c‐ jun , jun B, jun D and c‐ fos oncogene expression was investigated.

CAT assays revealed that c‐ jun overexpression in tumorigenic cells was associated with higher transcription activity.

c‐ jun , but not jun B, jun D or c‐ fos , was overexpressed in highly tumorigenic clones. The reversion of cells to the non‐tumorigenic phenotype resulted in a dramatic decrease in c‐ jun expression. No correlation between c‐ jun oncogene expression and AP‐1 transcription factor activity in tumorigenic and non‐tumorigenic clones was found.
The paper discusses methods that ensure the execution of only correct and legal control commands in the process control system.

Protection of the integrity of the APCS software at all nodes of the industrial network, including protection against unauthorized substitution, is carried out by checking the control parameters of the software during their startup. Protection of control commands from distortions during transmission over the network is realized by double coding at different levels of the system. Protection against the submission of unauthorized control commands to technological equipment is carried out by recognizing these commands in the lower-level subsystem and comparing their current characteristics with the control ones.

A certain contribution to the safety of the process control system is made by the use of a secure execution environment – OS CentOS 7.
The critical environmental situation in the region of southwestern Siberia (Komsomolsk settlement, Kemerovo region) is the result of the intentional displacement of mine tailings with high sulfide concentrations. During storage, ponds of acidic water with incredibly high arsenic (up to 4 g/L) and metals formed on the tailings.

The application of chemical methods to treat these extremely toxic waters is implemented: milk of lime Ca(OH)2, sodium sulfide Na2S, and sodium hydroxide NaOH. Field experiments were carried out by sequential adding pre-weighed reagents to the solutions with control of the physicochemical parameters and element concentrations for each solution/reagent ratio. In the experiment with Ca(OH)2, the pH increased to neutral values most slowly, which is contrary to the results from the experiment with NaOH. When neutralizing solutions with NaOH, arsenic-containing phases are formed most actively, arsenate chalcophyllite Cu18Al2(AsO4)4(SO4)3(OH)24·36H2O, a hydrated iron arsenate scorodite, kaatialaite FeAs3O9·8H2O and Mg(H2AsO4)2. A common specificity of the neutralization processes is the rapid precipitation of Fe hydroxides and gypsum, then the reverse release of pollutants under alkaline conditions. The chemistry of the processes is described using thermodynamic modeling.

The main species of arsenic in the solutions are iron-arsenate complexes; at the end of the experiments with Ca(OH)2, Na2S, and NaOH, the main species of arsenic is CaAsO4−, the most toxic acid H3AsO3 and AsO43−, respectively. It is recommended that full-scale experiments should use NaOH in the first stages and then Ca(OH)2 for the subsequent neutralization.