Hengzongshu/ArticleAgent huggingface dataset:
The aim of the study was to evaluate cell-free DNA (cfDNA) in the follicular fluid (FF) of women undergoing IVF treatment and to analyze the relationship between cfDNA levels and the parameters of folliculogenesis and oogenesis as well as the quality of embryos.

Materials and methods. The study included 53 women aged 20 to 45 years. In 49 patients, oocytes were obtained by stimulating ovulation with gonadotropins, and 4 patients underwent natural cycle IVF without hormonal stimulation. Measurement of cfDNA was carried out by fluorimetry using QuantiFluor™ Handheld Fluorometers (BioSilica, Russian Federation).

Results. The FF of women with ovulation stimulation revealed a higher level of cfDNA as opposed to FF of women in the natural cycle. There were no differences in the cfDNA levels in women with infertility and oocyte donors. Women with infertility lasting for more than 5 years had a higher level of cfDNA. Women with the elevated anti-Mullerian hormone (AMH) levels were characterized by the high FF cfDNA concentration and a large number of follicles. Likewise, correlation analysis showed that FF cfDNA was significantly and positively correlated with the AMH level. The obtained data revealed the participation of cfDNA in different stages of oogenesis. Conclusions. The level of FF cfDNA in women may serve as an additional biomarker of the effectiveness of ovulation induction.
Using a proton-proton collision data sample corresponding to an integrated luminosity of 3 fb(-1) collected by LHCb at center-of-mass energies of 7 and 8 TeV, about 3800 Ξ(b)(0) → Ξ(c)(+)π(-), Ξ(c)(+)) → pK(-)π(+) signal decays are reconstructed. From this sample, the first measurement of the Ξ(b)(0) baryon lifetime is made, relative to that of the Λ(b)(0) baryon. The mass differences M(Ξ(b)(0))-M(Λ(b)(0)) and M(Ξ(c)(+))-M(Λ(c)(+)) are also measured with precision more than 4 times better than the current world averages. The resulting values are τ(Ξ(b)(0))/τ(Λ)(b)(0)) = 1.006 ± 0.018 ± 0.010,M(Ξ(b)(0))-M(Λ(b)(0)) = 172.44 ± 0.39 ± 0.17 MeV/c(2),M(Ξ(c)(+))-M(Λ(c)(+)) = 181.51 ± 0.14 ± 0.10 MeV/c(2),where the first uncertainty is statistical and the second is systematic. The relative rate of Ξ(b)(0) to Λ(b)(0) baryon production is measured to be f(Ξ)(b)(0))/f(Λ)(b)(0))B(Ξ(b)(0) → Ξ(c)(+)π(-))/B(Λ(b)(0) → Λ(c)(+)π(-))B(Ξ(c)(+) → pK(-)π(+))/B(Λ(c)(+) → pK(-)}π(+)) = (1.88 ± 0.04 ± 0.03) × 10(-2),where the first factor is the ratio of fragmentation fractions, b → Ξ(b)(0) relative to b → Λ(b)(0). Relative production rates as functions of transverse momentum and pseudorapidity are also presented.
In this article, we study a connection between quasiisometric mappings of n-dimensional domains and the p-moduli of path families.In particular, we obtain explicit (and sharp) estimates for the distortion of the p-moduli of path families under K-quasi-isometric mappings.
Death-inducing signaling complex (DISC) and death effector domain (DED) filaments control extrinsic apoptosis. DED filaments comprise FADD, procaspase-8/10, and c-FLIP. Post-translational modifications (PTMs) of DED filament proteins create the additional checkpoint of apoptosis. Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction.

In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament. The structure of the DED filaments has been recently solved by cryogenic electron microscopy (cryo-EM) structural analysis of the procaspase-8 N terminal prodomain. The assembly of the DED filament is mediated by three types of DED interactions: type I, II, and III. Recent findings are revealing a role for post-translational modifications (PTMs) such as phosphorylation, ubiquitylation, SUMOylation, and nitrosylation in regulating these interactions.

A central role in understanding apoptosis control is in deciphering the 3D architecture of PTMs in the DED filament. These modifications assist in maintaining proper conformations of DEDs in DED filaments, which is required for efficient caspase-8 activation, and in overcoming a threshold for apoptosis induction. The proper structural conformation of FADD is a requirement for the initiation of DED filament growth. Hence, its modulation by PTM might have major consequences for apoptosis initiation.
This paper studies the integration of regional goods markets in Russia over the period 2001–19, analysing the law of one price. The analysis involves all pairs of country's regions, which provides a comprehensive spatial pattern of market integration. The region pairs are classified as belonging to one of four groups: perfectly integrated, conditionally integrated, not integrated but tending towards integration (converging), and neither integrated nor tending towards integration. On average, a region is found to be perfectly and conditionally integrated with 48.7% of other regions and tending towards integration with 3.3% of them. Comparisons of the European and Asian parts of Russia and other considerations suggest that geographical reasons explain the pattern obtained only partially. Apparently, idiosyncratic features of regional markets play a main role in non-integration.
This short review summarizes our contribution to the coordination chemistry of noble metals (organometallic fragments of Rh, Ir, Ru and hydroxo Pt(IV)) and polyoxocomplexes of niobium and tantalum.
Investigation results on the morphology and optical properties of polymer-graphene composites with silver nanoparticles deposited by pulsed laser ablation are presented. Graphene was obtained by the CVD method and transferred to PET/EVA polymer through thermal pressing.

It has been established that with an increase in the thickness of deposited silver film, a transition from bimodal distribution of particles to formation of elongated rectangular nanostructures is observed. A similar phenomenon can be explained by accumulation of deposited silver particles along the boundaries of adjacent graphene crystallites. It is experimentally shown that the degree of plasmon absorption depends strongly on the mass-average thickness of the deposited metal coating and size of nanoparticles.

Deepening of the peak of plasmon absorption simultaneously with a general decrease in sample transparency occurs when the film thickness is changed up to 6 nm. A further increase in thickness does not affect the intensity of plasmon absorption and scattering, but leads to a general decrease in transparency of the polymer-graphene-silver composite. It is shown that the highest degree of radiation attenuation is in the wavelength range from 400 to 600 nm.
The thermophilic fungus Chaetomium thermophilum holds great promise for structural biology. To increase the efficiency of its biochemical and structural characterization and to explore its thermophilic properties beyond those of individual proteins, we obtained transcriptomics and proteomics data, and integrated them with computational annotation methods and a multitude of biochemical experiments conducted by the structural biology community. We considerably improved the genome annotation of Chaetomium thermophilum and characterized the transcripts and expression of thousands of genes. We furthermore show that the composition and structure of the expressed proteome of Chaetomium thermophilum is similar to its mesophilic relatives. Data were deposited in a publicly available repository and provide a rich source to the structural biology community.
Exclusive measurements of the quasi-free pn→ppπ− and pp→ppπ0 reactions have been performed by means of pd collisions at Tp=1.2 GeV using the WASA detector setup at COSY. Total and differential cross sections have been obtained covering the energy region Tp=0.95–1.3GeV (s=2.3–2.46 GeV), which includes the regions of Δ(1232), ⁎N⁎(1440) and ⁎d⁎(2380) resonance excitations. From these measurements the isoscalar single-pion production has been extracted, for which data existed so far only below Tp=1 GeV. We observe a substantial increase of this cross section around 1 GeV, which can be related to the Roper resonance ⁎N⁎(1440), the strength of which shows up isolated from the Δ resonance in the isoscalar (Nπ)I=0 invariant-mass spectrum. No evidence for a decay of the dibaryon resonance ⁎d⁎(2380) into the isoscalar (NNπ)I=0 channel is found. An upper limit of 180 μb (90% C.L.) corresponding to a branching ratio of 9% has been deduced.
Funding Acknowledgements Type of funding sources: None. Purpose. To study the possibility of conducting the ‘Primary and Secondary Prevention of Cardiovascular Diseases’ educational programme aimed at promoting health literacy among cardiology blog followers on Instagram. Material and methods. In the present study the methodology for conducting the educational programme on Instagram included the following: choosing the agents of influence and format of audience engagement; determining the most relevant topics and time frames; identifying the frequency and characteristics depending on the selected format of audience engagement; developing evaluation metrics; conducting the programme; evaluation of study results; defining the scaling strategy. The educational programme was conducted daily from 19 to 30March 2020 through professional medical accounts on Instagram. The programme format included posts of up to 4,000 characters on primary (healthy diet, smoking cessation, physical activity, obesity, vegetarian diet) and secondary prevention (drug treatment) of cardiovascular diseases. The study results were evaluated by descriptive statistics for standard social network metrics. Results. The total number of cardiology blog followers is 367,727. The audience of professional doctors" blogs is mostly female (89 to 95%), the age group of 25 to 34 years accounts for 40 to 47% of the followers. Ten posts of the educational programme were viewed by a total of 104,794 users, gathering a total of 9,692 audience engagements (comments, shares, likes and saves). Such topics as consumption of vegetables, salt and sugar, physical activity and obesity accounted for the highest audience engagement (1,146; 1,100; 2,195; 1,052 and 1,534 users, respectively). Conclusions. The Instagram social network can be used for educational programmes aimed at promoting health literacy among Russian people. It is necessary to further improve the methodology for conducting research in social networks in order to select the most effective technologies that contribute to the preservation of public health.
The Klyuchevskoy group of volcanoes (KGV) in Kamchatka includes three presently active volcanoes (Klyuchevskoy, Bezymianny, and Tolbachik) located close together in an area of approximately 50 × 80 km. These three volcanoes have completely different compositions and eruption styles from each other.

We have analyzed new data recorded by a temporary seismic network consisting of 22 seismic stations operated within the area of Tolbachik in 2014–2015 in conjunction with the data from the permanent network and the temporary PIRE network deployed at the Bezymianny volcano in 2009. The arrival times of the P and S waves were inverted using a local earthquake tomography algorithm to derive 3‐D seismic models of the crust beneath the KGV as well as accurate seismicity locations. High‐resolution structures beneath the Tolbachik volcanic complex were identified for the first time in this study.

The tomography results reveal three different types of feeding system for the main KGV volcanoes. The basaltic lavas of the Klyuchevskoy volcano are supplied directly from a reservoir at a depth of 25–30 km through a nearly vertical pipe‐shaped conduit. The explosive Bezymianny volcano is fed through a dispersed system of crustal reservoirs where a lighter felsic material separates from the mafic component and ascends to the upper crust to form andesitic magma sources. For Tolbachik, low‐viscosity volatile‐saturated basalts ascend from two deep reservoirs following a system of fractures in the crust associated with the intersections of regional faults.
The boiling heat transfer on the local heaters with microstructured and nanomodified surfaces was studied.

As nanomodified surfaces we used copper ones where the microropes of silicon oxide nanowires were grown. The aging of the nanomodified surface was observed after first series of experiments.

It was shown that both finning and nanostructuring of the surface result in increase of heat transfer. The heat flux density of 1400 W/cm2 was reached.
Temperature-induced oligomerization of polycyclic aromatic hydrocarbons (PAHs) was found at 500-773 K and ambient and high (3.5 GPa) pressures. The most intensive oligomerization at 1 bar and 3.5 GPa occurs at 740-823 K.

PAH carbonization at high pressure is the final stage of oligomerization and occurs as a result of sequential oligomerization and polymerization of the starting material, caused by overlapping of π-orbitals, a decrease of intermolecular distances, and finally the dehydrogenation and polycondensation of benzene rings.

Being important for building blocks of life, PAHs and their oligomers can be formed in the interior of the terrestrial planets with radii less than 2270 km.
A group classification of equations describing the motion of a liquid metal with the inclusion of nanopowder inoculators is carried out in relation to the dependence of the viscosity coefficient on temperature and the fraction of the solid phase in the melt.

The motion of a liquid metal with the inclusion of nanopowder inoculators will be described by the Navier— Stokes system of equations in an axisymmetric coordinate system taking into account the force of gravity directed against the axial coordinate and the heat transfer equation in a liquid, taking into account crystallization. The viscosity of a liquid is considered dependent on temperature and the fraction of the solid phase in the melt.

The widest permissible group is obtained in the case of a constant viscosity coefficient. Also, the expansion of the permissible group occurs with some special types of dependence of the viscosity coefficient on temperature and the fraction of the solid phase in the melt.
The paper considers the use of a convolution neural network for detecting first arrivals for a real set of 3D seismic data with more than 4.5 million traces. Detection of the first breaks for each trace is carried out independently. The error between the original and the predicted first breaks is no more than 3 samples for 95% of the data. Quality control is performed by calculating static corrections and seismic stacks, which showed the effectiveness of the proposed approach.
DNA of living cells is always exposed to damaging factors. To counteract the consequences of DNA lesions, cells have evolved several DNA repair systems, among which base excision repair is one of the most important systems. Many currently used antitumor drugs act by damaging DNA, and DNA repair often interferes with chemotherapy and radiotherapy in cancer cells. Tumors are usually extremely genetically heterogeneous, often bearing mutations in DNA repair genes. Thus, knowledge of the functionality of cancer-related variants of proteins involved in DNA damage response and repair is of great interest for personalization of cancer therapy. Although computational methods to predict the variant functionality have attracted much attention, at present, they are mostly based on sequence conservation and make little use of modern capabilities in computational analysis of 3D protein structures.

We have used molecular dynamics (MD) to model the structures of 20 clinically observed variants of a DNA repair enzyme, 8-oxoguanine DNA glycosylase. In parallel, we have experimentally characterized the activity, thermostability, and DNA binding in a subset of these mutant proteins.

Among the analyzed variants of 8-oxoguanine DNA glycosylase, three (I145M, G202C, and V267M) were significantly functionally impaired and were successfully predicted by MD. Alone or in combination with sequence-based methods, MD may be an important functional prediction tool for cancer-related protein variants of unknown significance.
Local finiteness is proved for groups of exponent dividing 72 with no elements of order 6.
It was found that antibodies (Abs) against myelin basic protein (MBP) are the major components of the antibody response in multiple sclerosis (MS) patients. We have recently shown that IgGs from sera of MS patients are active in the hydrolysis of MBP. However, in literature there are no available data concerning possible MBP-hydrolyzing Abs in cerebrospinal fluid (CSF) of MS patients. We have shown that the average content of IgGs in their sera is about 195-fold higher than that in their CSF. Here we have compared, for the first time, the average content of lambda- and kappa-IgGs as well as IgGs of four different subclasses (IgG1-IgG4) in CSF and sera of MS patients. The average relative content of lambda-IgGs and kappa –IgGs in the case of CSFs (8.0 and 92.0%) and sera (12.3 and 87.7%) are comparable, while IgG1, IgG2, IgG3, and IgG4: CSF - 40.4, 49.0, 8.2, and 2.5% of total IgGs, respectively and the sera - 53.6, 36.0, 5.6, and 4.8%, decreased in different order. Electrophoretically and immunologically homogeneous IgGs were obtained by sequential affinity chromatography of the CSF proteins on protein G-Sepharose and FPLC gel filtration. We present first evidence showing that IgGs from CSF efficiently hydrolyze MBP and that their average specific catalytic activity is unpredictably ∼54-fold higher than that of Abs from sera of the same MS patients. Some possible reasons of these findings are discussed. We suggest that anti-MBP abzymes of CSF may promote important neuropathologic mechanisms in this chronic inflammatory disorder and in MS pathogenesis development.
In this paper, we present the first detailed study on the chromitites and platinum-group element mineralization (PGM) of the Ulan-Sar’dag ophiolite (USO), located in the Central Asian Fold Belt (East Sayan).

Three groups of chrome spinels, differing in their chemical features and physical–chemical parameters, under equilibrium conditions of the mantle mineral association, have been distinguished. The temperature and log oxygen fugacity values are, for the chrome spinels I, from 820 to 920 °C and from (−0.7) to (−1.5); for chrome spinels II, 891 to 1003 °C and (−1.1) to (−4.4); and for chrome spinels III, 738 to 846 °C and (−1.1) to (−4.4), respectively. Chrome spinels I were formed through the interaction of peridotites with mid-ocean ridge basalt (MORB)-type melts, and chrome spinels II were formed through the interaction of peridotites with boninite melts. Chrome spinels III were probably formed through the interaction of andesitic melts with rocks of an overlying mantle wedge.

Chromitites demonstrate the fractionated form of the distribution of the platinum-group elements (PGE), which indicates a high degree of partial melting at 20–24% of the mantle source. Two assemblages of PGM have been distinguished: The primary PGE assemblage of Os-Ir-Ru alloys-I, (Os,Ru)S2, and IrAsS, and the secondary PGM assemblage of Os-Ir-Ru alloys-II, Os0, Ru0, RuS2, OsS2, IrAsS, RhNiAs with Ni, Fe, and Cu sulfides. The formation of the secondary phases of PGE occurred upon exposure to a reduced fluid, with a temperature range of 300–700 °C, log sulfur fugacity of (−20), and pressure of 0.5 kbar. We have proposed a scheme for the sequence of the formation and transformation of the PGMs at various stages of the evolution of the Ulan-Sar’dag ophiolite.
The one-dimension Russo--Smereka kinetic equation describing the propagation of nonlinear concentration waves in a rarefied bubbly fluid is considered.

Reductions of the model to finite component systems are derived. Stability of the bubbly flow in terms of hyperbolicity of the kinetic equation is studied.

Conservation form of the model is proposed and numerical solution of the Cauchy problem with discontinuous initial data is obtained.
Existence of the density limit in the helicon plasma sources is critically revisited. The low- and high-frequency regimes of a helicon plasma source operation are distinguished.

In the low-frequency regime with $\omega \sqrt{\omega_{ci}\omega_{ce}}$, an appropriate limit is given by the Shamrai-Taranov criterion. Both these criteria are closely related to the phenomenon of the coalescence of the helicon wave with the Trivelpiece-Gould mode.

We argue that theoretical density limits are not achieved in existing devices but might be met in the future with the increase of applied rf power.
An analysis of the existing database gained in the experiments at the open magnetic systems in the Budker Institute and worldwide is presented.

To develop the required database a stepwise approach is applied, which suggests construction of the several experimental devices with progressively increased plasma parameters, which incorporate the different constituents of the approach.

we present the Budker Institute long term plans for development of the plasma physics database for an advanced fuel fusion reactor based on the axisymmetric linear magnetic trap.
In the paper we discuss a biomechanical model of microcirculation and transcapillary metabolism

and present a mathematical model of metabolic processes occurring in microcirculation level. We conside the following interrelated processes: the flow of blood (a non-Newtonian fluid) in capillaries; filtration and reabsorption of fluid through the wall of the arterial capillary into the surrounding tissue and from this one back to the venous capillary; the movement of fluid in the interstices, the exchange of substances between the interstitial fluid and tissue cells, drainage into the lymphatic capillaries. Biological tissue is modeled as a porous, resilient, isotropic matrix or frame saturated with a fluid of the same type. It is believed that the liquid is contained in the pores of the matrix.

The study of microcirculation allows you to better understand the complex interlinked processes of metabolism in the body, identify the causes of pathologies and suggest possible treatment interstitium.