Hengzongshu/ArticleAgent huggingface dataset:
Background and objectives: Malignant pleural mesothelioma (MPM) is a devastating malignancy with poor prognosis. Reliable biomarkers for MPM diagnosis, monitoring, and prognosis are needed. The aim of this study was to identify genes associated with wound healing processes whose expression could serve as a prognostic factor in MPM patients. Materials and Methods: We used data mining techniques and transcriptomic analysis so as to assess the differential transcriptional expression of wound-healing-associated genes in MPM. Moreover, we investigated the potential prognostic value as well as the functional enrichments of gene ontologies relative to microRNAs (miRNAs) of the significantly differentially expressed wound-healing-related genes in MPM. Results: Out of the 82 wound-healing-associated genes analyzed, 30 were found significantly deregulated in MPM. Kaplan–Meier analysis revealed that low ITGAV gene expression could serve as a prognostic factor favoring survival of MPM patients. Finally, gene ontology annotation enrichment analysis pointed to the members of the hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members as important regulators of the deregulated wound healing genes. Conclusions: 30 wound-healing-related genes were significantly deregulated in MPM, which are potential targets of hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members. Out of those genes, ITGAV gene expression was a prognostic factor of overall survival in MPM. Our results highlight the role of impaired tissue repair in MPM development and should be further validated experimentally.
Outsourced computations and, more particularly, cloud computations, are widespread nowadays.That is why the problem of keeping the data security arises.Multiple fully homomorphic cryptosystems were proposed in order to perform secret computations in untrusted environments.But most of the existent solutions are practically inapplicable as they require huge computation resources and produce big (∼1Gb) keys and ciphertexts.Therefore, we propose the undemanding fully homomorphic scheme with practically acceptable (∼few Kb) keys and output data.Our solution uses modular arithmetic in order to avoid the increase in data size.We have validated our approach through the implementation of the proposed cryptosystem.The details of used algorithms and the results of security evaluation are covered in this paper.
The TAIGA (Tunka Advanced Instrument for cosmic rays and Gamma-Astronomy) observatory is designed to study the gamma ray sources and galactic cosmic rays. It is located in the Tunka Valley 50 km from the lake Baikal (Siberia). The first part of TAIGA called the EAS Cherenkov array TAIGA-HiSCORE currently consists of 28 wide-angle (0.6 sr) stations, distributed over an area of 0.25 km^2. The Crab observation exposure was about 115 hours during the winter seasons of 2016-2017. The expected gamma quanta excess depends on the array energy threshold and a model of the Crab energy spectrum extrapolation to the higher energies. We present preliminary results of experimental data and MC simulations comparison as well as energy threshold and angular resolutions. The experimental data is in a good agreement with the simulations. An excess of events (about 25 events in the region 30-63 TeV) observed from the Crab direction is compatible with the expected one.
The taxonomy of the genus Calomyscus remains controversial. According to the latest systematics the genus includes eight species with great karyotypic variation. Here, we studied karyotypes of 14 Calomyscus individuals from different regions of Iran and Turkmenistan using a new set of chromosome painting probes from a Calomyscus sp. male (2n = 46, XY; Shahr-e-Kord-Soreshjan-Cheshme Maiak Province). We showed the retention of large syntenic blocks in karyotypes of individuals with identical chromosome numbers. The only rearrangement (fusion 2/21) differentiated Calomyscus elburzensis, Calomyscus mystax mystax, and Calomyscus sp. from Isfahan Province with 2n = 44 from karyotypes of C. bailwardi, Calomyscus sp. from Shahr-e-Kord, Chahar Mahal and Bakhtiari-Aloni, and Khuzestan-Izeh Provinces with 2n = 46. The individuals from Shahdad tunnel, Kerman Province with 2n = 51–52 demonstrated non-centric fissions of chromosomes 4, 5, and 6 of the 46-chromosomal form with the formation of separate small acrocentrics. A heteromorphic pair of chromosomes in a specimen with 2n = 51 resulted from a fusion of two autosomes. C-banding and chromomycin A3-DAPI staining after G-banding showed extensive heterochromatin variation between individuals.
Circumstellar discs, from which planetary systems are formed, consist of gas, dust and solids. Simulations of self-consistent dynamics of gas, dust and solids in circumstellar discs is a challenging problem. In the paper we present fast algorithms for computing the drag force (momentum transfer) between solid phase and gas. These algorithms (a) are universal and applicable to dust and solids with any sizes smaller than the mean free path of gas molecules, (b) can be used to calculate the momentum transfer between dust and gas instead of one-way effect, as it is done in many models, (c) can perform simulations, without a loss in accuracy, with the time step determined by gas-dynamic parameters rather than by drag force, and (d) are compatible with the widely used parallel algorithms for solving 3D equations of gas dynamics, hydrodynamic equations for dust, and the collisionless Boltzmann equation for large bodies. Preliminary results of supercomputer simulation of the gas-dust disc dynamics within the developed approach are reported.
We investigate lateral p-n junctions, electrostatically defined in 14 nm-wide HgTe-based quantum wells (QWs) with inverted band structure. The p-n junctions resistances are close to $h/2e^2$, consistent with some previous experiments on 8-10 nm QWs, and the current-voltage characteristics are highly linear, indicating the transport via ballistic helical edge states. Shot noise measurements are performed in order to further verify the underlying transport mechanism. We discuss the role of unknown inelastic relaxation rates in the leads and in the edge channels for the correct interpretation of the noise data. Although the interpretation in favor of the helical edge states seems more consistent, a definite conclusion can not be drawn based on the present experiment. Our approach looks promising for the study of short quasi-ballistic edges in topological insulators (TIs) in suitable geometry.
In this work, an economic assessment of environmental damage to water and land resources is calculated, and the cost of a project for the reclamation of destroyed lands within the territory of the Komsomolsk gold recovery plant is determined. The object of the study is directly the territory of the enterprise, which is located in the Tisulsky municipal district of the Kemerovo region.

According to our calculations, the total assessment of environmental damage from the plant’s activities amounted to 458 million rubles, of which: 294 million rubles – accumulated environmental damage from water pollution; 164 million rubles – accumulated environmental damage from soil pollution in the surrounding area.

The cost estimate of the destroyed land reclamation project amounted to 716.7 million rubles. At the same time, income from the sale of equipment and gold mined in the territory of the tailing dump reaches 3916 million rubles.
Представлены результаты фемтосекундной записи волоконных брэгговских решеток (ВБР) первого и второго порядков через защитное пластиковое покрытие световода.

В частности, записаны однородные решетки в нефоточувствительных световодах с полиимидной оболочкой SMP1500 (9/125) P и SMP1500SC (9/125) P (с чисто кварцевой сердцевиной), спектр отражения которых хорошо согласуется с расчетом.

Показано, что данный метод позволяет также записывать суперструктурированные ВБР.
It is known that the physico-chemical characteristics of proteins underlying specific folding of the polypeptide chain and the protein function are evolutionary conserved. Detection of such characteristics while analyzing homologous sequences would expand essentially the knowledge on protein function, structure, and evolution. These characteristics are maintained constant, in particular, by co-ordinated substitutions. In this process, the destabilizing effect of a substitution may be compensated by another substitution at a different position within the same protein, making the overall change in this protein characteristic insignificant. Consequently, the patterns of co-ordinated substitutions contain important information on conserved physico-chemical properties of proteins, requiring their investigation and development of the corresponding methods and software for correlation analysis of protein sequences available to a wide range of users.

A software package for analyzing correlated amino acid substitutions at different positions within aligned protein sequences was developed. The approach implies searching for evolutionary conserved physico-chemical characteristics of proteins based on the information on the pairwise correlations of amino acid substitutions at different protein positions. The software was applied to analyze DNA-binding domains of the homeodomain class.

As a result, two conservative physico-chemical characteristics preserved due to the co-ordinated substitutions at certain groups of positions in the protein sequence. Possible functional roles of these characteristics are discussed.
We study numerically the properties of (statistically) homogeneous soliton gas depending on soliton density (proportional to number of solitons per unit length) and soliton velocities, in the framework of the focusing one-dimensional Nonlinear Schr{\"o}dinger (NLS) equation. In order to model such gas we use N-soliton solutions (N-SS) with $N\sim 100$, which we generate with specific implementation of the dressing method combined with 100-digits arithmetics. We examine the major statistical characteristics, in particular the kinetic and potential energies, the kurtosis, the wave-action spectrum and the probability density function (PDF) of wave intensity. We show that in the case of small soliton density the kinetic and potential energies, as well as the kurtosis, are very well described by the analytical relations derived without taking into account soliton interactions. With increasing soliton density and velocities, soliton interactions enhance, and we observe increasing deviations from these relations leading to increased absolute values for all of these three characteristics. The wave-action spectrum is smooth, decays close to exponentially at large wavenumbers and widens with increasing soliton density and velocities. The PDF of wave intensity deviates from the exponential (Rayleigh) PDF drastically for rarefied soliton gas, transforming much closer to it at densities corresponding to essential interaction between the solitons. Rogue waves emerging in soliton gas are multi-soliton collisions, and yet some of them have spatial profiles very similar to those of the Peregrine solutions of different orders. We present example of three-soliton collision, for which even the temporal behavior of the maximal amplitude is very well approximated by the Peregrine solution of the second order.
A chromodomain is a domain contained in various proteins involved in chromatin remodeling and the regulation of gene expression in eukaryotes during development. Chromodomains perform a wide range of diverse functions including chromatin targeting and interactions between different proteins, RNA and DNA.

The chromodomains also have been found as an additional domain at the C-terminal region of Polyproteins (Pol) encoded by transposable elements, which belong to the Gypsy LTR retrotransposons superfamily. Chromoviruses or chromodomain-containing Gypsy LTR retrotransposons form the most widespread clade of Gypsy LTR retrotransposons and can be found in diverse eukaryotes including plants, fungi and vertebrates.

The recent finding suggested that chromodomains can be responsible for the targeted integration of LTR retrotransposons and, thus, should be favorable for mobile elements by allowing them to avoid negative selection arising from insertion into coding regions.
P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. For example, previously we demonstrated that administration of p62/SQSTM1-encoding plasmid reduced chronic inflammation and alleviated osteoporosis and metabolic syndrome in animal models.

Herein, we built upon these findings to investigate effect of the p62-encoding plasmid on an age-related macular degeneration (AMD), a progressive neurodegenerative ocular disease, using spontaneous retinopathy in senescence-accelerated OXYS rats as a model.

Overall, the p62DNA decreased the incidence and severity of retinopathy. In retinal pigment epithelium (RPE), p62DNA administration slowed down development of the destructive alterations of RPE cells, including loss of regular hexagonal shape, hypertrophy, and multinucleation. In neuroretina, p62DNA prevented gliosis, retinal thinning, and significantly inhibited microglia/macrophages migration to the outer retina, prohibiting their subretinal accumulation. Taken together, our results suggest that the p62DNA has a strong retinoprotective effect in AMD.
Domestication of wild animals alters the aggression towards humans, brain monoamines and coat pigmentation. Our aim is the interplay between aggression, brain monoamines and depigmentation. The Hedlund white mutation in the American mink is an extreme case of depigmentation observed in domesticated animals. The aggressive (-2.06 ± 0.03) and tame (+3.5 ± 0.1) populations of wild-type dark brown color (standard) minks were bred during 17 successive generations for aggressive or tame reaction towards humans, respectively. The Hedlund mutation was transferred to the aggressive and tame backgrounds to generate aggressive (-1.2 ± 0.1) and tame (+3.0 ± 0.2) Hedlund minks. Four groups of 10 males with equal expression of aggressive (-2) or tame (+5) behavior, standard or with the Hedlund mutation, were selected to study biogenic amines in the brain. Decreased levels of noradrenaline in the hypothalamus, but increased concentrations of the serotonin metabolite, 5-hydroxyindoleacetic acid and dopamine metabolite, homovanillic acid, in the striatum were measured in the tame compared with the aggressive standard minks. The Hedlund mutation increased noradrenaline level in the hypothalamus and substantia nigra, serotonin level in the substantia nigra and striatum and decreased dopamine concentration in the hypothalamus and striatum. Significant interaction effects were found between the Hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (P < 0.001), dopamine level in the midbrain (P < 0.01) and its metabolism in the striatum (P < 0.05). These results provide the first experimental evidence of the interplay between aggression, brain monoamines and the Hedlund mutation in the American minks.
Background Social cohesion has a potential protective effect against depression, but evidence for Central and Eastern Europe is lacking. We investigated the prospective association between social cohesion and elevated depressive symptoms in the Czech Republic, Russia and Poland, and assessed whether alcohol drinking and smoking mediated this association. Methods Cohort data from 15 438 older urban participants from the Health, Alcohol and Psychosocial factors In Eastern Europe project were analysed. Baseline social cohesion was measured by five questions, and depressive symptoms were measured 3 years later by the 10-item Center for Epidemiological Depression (CES-D) Scale. Nested logistic regression models estimated ORs of elevated depressive symptoms (CES-D 10 score ≥4) by z-scores and tertiles of social cohesion. Results Per 1 SD decrease in social cohesion score, adjusted ORs of elevated depressive symptoms were 1.13 (95% CI 1.05 to 1.23) and 1.05 (95% CI 0.99 to 1.13) in men and women, respectively. Further adjustment for smoking and drinking did not attenuate these associations in either men (OR=1.13, 95% CI 1.05 to 1.22) or women (OR=1.05, 95% CI 0.99 to 1.13). Similarly, the fully adjusted ORs comparing the lowest versus highest social cohesion tertile were 1.33 (95% CI 1.10 to 1.62) in men and 1.18 (95% CI 1.01 to 1.39) in women. Conclusions Lower levels of social cohesion was associated with heightened depressive symptoms after a 3-year follow-up among older Czech, Russian and Polish adults. These effects appeared stronger in men, and alcohol and smoking played no appreciable role in this association.
ABSTRACT Objective To investigate how tobacco and tea spread among virgin populations and how the first addictions have subsequently influenced the behavior of present-day populations. Design Retrospective observational study using data from frozen burials and levels of theobromine, theophylline, caffeine, nicotine, and cotinine measured in hair samples from frozen bodies of autochthonous people. Confrontation of the results with new ethnobotanical, historical and cultural data from the past and with present day epidemiological data from the same region. Setting Eastern Siberia (Yakutia) from the contact with Europeans (17th century) to the assimilation of people into Russian society (19 th century). Participants 47 frozen bodies of autochthonous people from eastern Siberia and a review of present-day populations from Yakutia Intervention Levels of theobromine, theophylline, caffeine, nicotine, and cotinine were measured in hair samples. Along with the collection of cultural data associated with the bodies, potential comorbidities were investigated. Main outcome measure We combined LC-HRMS and LC-MS/MS tools for toxicological investigations in hair and we assessed the association between xenobiotic concentrations and geography using several permutation-based methods to infer the economic circuits of tobacco and tea. Comparison of the results obtained with ethno-botanical analyses allowed to identify the products from which the metabolites were derived. Results Hair levels of theobromine, theophylline and caffeine vary with the type of beverage consumed: green, black or local herbal teas. At the beginning of our study period, a few heavy consumers of tobacco were found among light or passive consumers. Tobacco-related co-morbidities began to be recorded one century after contact with Europeans. Heavy tea users were only found from the 19 th century and the heaviest users of the two substances date from this century. After the first contact, teas were widely consumed as beverages and medicines but also for shamanic reasons. Economic factors, fashion and social and family contacts seem to have played a decisive role in tobacco consumption very early on. Conclusion Epidemiological characteristics of present-day Yakutia suggest that the high prevalence of smokers and tea consumers, the prevalence of female smokers and tobacco use in the north, find their origins in the diffusion phenomena of the 18th and 19th century. Behavioral evolution governed the process of substance integration and was determinant for the continuity of use of these substances over a long period of time.
Belyaev’s concept of destabilizing selection during domestication was a major achievement in the XX century. Its practical value has been realized in commercial colors of the domesticated fox that never occur in the wild and has been confirmed in a wide variety of pet breeds. Many human disease models involving animals allow to test drugs before human testing. Perhaps this is why investigators doing transcriptomic profiling of domestic versus wild animals have searched for breed-specific patterns. Here we sequenced hypothalamic transcriptomes of tame and aggressive rats, identified their differentially expressed genes (DEGs), and, for the first time, applied principal component analysis to compare them with all the known DEGs of domestic versus wild animals that we could find. Two principal components, PC1 and PC2, respectively explained 67% and 33% of differential-gene-expression variance (hereinafter: log2 value) between domestic and wild animals. PC1 corresponded to multiple orthologous DEGs supported by homologs; these DEGs kept the log2 value sign from species to species and from tissue to tissue (i.e., a common domestication pattern). PC2 represented stand-alone homologous DEG pairs reversing the log2 value sign from one species to another and from tissue to tissue (i.e., representing intraspecific and interspecific variation).
This article examines Ivan Danilovich Khokhlovs mission to the Khanate of Bukhara in the early 17th century to gain a better understanding of the Russian envoys links with the Central Asian states.

Working with the embassys report and related sources, the author looks at both the official and unofficial contacts of the missions members and pays particular attention to identifying with whom they dealt. Together with his interpreter, Khohklov worked hard to set up a network of horizontal contacts to provide him with comprehensive and detailed intelligence.

Unusually, the diplomat limited himself to official contacts in building his information network. Endeavoring to improve relations, he described the ruling khans and those close to him, all the while making sure that he strictly adhered to Russian diplomatic protocol.
Positive environmental and technological contexts make dry methane reforming (DMR) an extensively studied reaction. During this process two main greenhouse gases CH 4 and CO 2 can be simultaneously converted into syngas – a mixture of CO and H 2 . Supported-nickel is one of the most frequently applied DMR catalysts. Their activity depends mainly on Ni concentration, kind of its precursor and a deposition method. As DMR is a demanding high-temperature reaction, it requires not only an active but first a very stable catalyst. Structural, textural and functional properties of such support remain thus of crucial efficiency. Main aim of this work was to elucidate how the synthesis of CeO 2 -ZrO 2 support obtained by supercritical fluid method ( i.e. at temperature of 400°C under a pressure of 25 MPa), can influence the properties of Ni-based DMR catalysts. The supports of various compositions (CeO 2 content from 100 to 0 %), subsequently calcined at 800°C for 6h in air have been analyzed. Nickel was deposited from nitrate(V) precursor via classical wet impregnation. The final catalysts have been characterized structurally (XRD, RS), texturally (BET, SEM) and functionally (UV/Vis-DR, XPS). Catalytic tests in dry methane reforming reaction have been performed to determine activity and stability of the synthesized samples.
Conversion of gravitational waves into electromagnetic radiation is discussed. The probability of transformations of gravitons into photons in presence of cosmological background magnetic field is calculated at the recombination epoch and during subsequent cosmological stages. The produced electromagnetic radiation is concentrated in the X-ray part of the spectrum. It is shown that if the early Universe was dominated by primordial black holes (PBHs) prior to Big Bang Nucleosynthesis (BBN), the relic gravitons emitted by PBHs would transform to an almost isotropic background of electromagnetic radiation due to conversion of gravitons into photons in cosmological magnetic fields. Such extragalactic radiation could be noticeable or even dominant component of Cosmic X-ray Background.