Hengzongshu/ArticleAgent huggingface dataset:
Aim. To evaluate the efficiency of cardioprotective therapy using intravenous metoprolol in combination with a high dose of atorvastatin in the prevention of myocardial remodeling (MR) and heart failure (HF) in patients with acute ST-segment elevation myocardial infarction (STEMI).

Material AND methods. A prospective study included 100 STEMI patients who underwent primary percutaneous intervention (PCI). Depending on the regimens of drug cardioprotection, three groups of patients were formed: the first (2014–2015) — 34 patients who received 80 mg atorvastatin as a part of the basic therapy on the first day of STEMI, then 20–40 mg/day for 30 days. The second group (2017–2018) — 34 patients who received atorvastatin 80 mg/day for a month from the onset of STEMI. The third group (2018–2019) — 32 patients who received intravenous metoprolol tartrate (5–15 mg) and atorvastatin 80 mg/day before PCI for a month from the onset of STEMI. On days 1 and 2 of STEMI and one month later, patients were assessed for serum levels of cardiac biomarkers; on the 1st, 7th days and one month later, echocardiographic studies (EchoCG) were performed. At the end of the observation, clinical and imaging outcomes (MR and HF) were assessed, which were compared with the dynamics of biomarkers between the groups of patients.

Results. The combined use of atorvastatin 80 mg/day for a month from the onset of STEMI and a single intravenous injection of metoprolol tartrate (5–15 mg) in the acute phase of STEMI before PCI showed the most significant effects in the prevention of the development of structural and functional myocardial disorders and clinically severe heart failure, and also caused the minimal serum activity of cardiomarkers in the third group of patients in comparison with the first and second groups of patients without this drug combination. Also, correlations between biomarkers and echocardiography indicators were established in the third group of patients who received cardioprotective therapy. Conclusion. The combined use of high-dose atorvastatin for a month with a single intravenous injection of metoprolol tartrate in acute STEMI before PCI prevents the formation of MR and clinically significant HF in the post-infarction period. Comprehensive dynamic assessment of cardiac biomarkers and echocardiography parameters within a month after post-STEMI is a highly informative tools for monitoring the efficiency of cardioprotective therapy.
While performing vegetation surveys in the southern part of the Lena delta, a new species of Carex from section Phacocystis has been found. Morphologically, Carex delongii sp. nov. is most close to C. cespitosa and C. minuta but differs from the former in smaller inflorescences, shorter pistillate spikes, narrow and soft leaves, oblong-ovoid (vs. ovoid) utricles; from the latter, it is distinguished by having smaller spikes and larger utricles. This relationship is also confirmed by molecular data. A detailed description of Carex delongii, its comparison with related species, illustrations, characteristics of habitat and phylogenetic position are reported.
BackgroundA group of helminth infections, caused by liver flukes of the trematode family Opisthorchiidae, were recently the focus of discussions at a meeting where scientists from Russia, Southeast Asia, Europe, and the United States came together in Tomsk city in Western Siberia (Russia) to form a Tomsk OPIsthorchiasis Consortium (TOPIC).This initiative starts a platform to raise awareness, to strengthen integrated control, and to conduct research on a neglected infectious disease that afflicts populations not only in the tropical regions of East Asia but also in temperate and semi-arctic areas of Europe and Asia [1].The Opisthorchiidae of importance to humans are Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis, each of which has a discrete, though occasionally overlapping, geographical distribution: O. felineus is endemic in Europe and Russia; C. sinensis in China, the Republic of Korea, and northern Vietnam; and O. viverrini in Southeast Asia.Together they affect more than 45 million people worldwide [2].

Human infection with O. felineus results from eating raw or undercooked freshwater fish carrying the metacercariae of the parasite.The ingested larvae develop further and migrate to the bile ducts by chemotaxis, where adult worms feed on biliary epithelia and contents in the bile.Adult worms shed eggs that enter the gastrointestinal tract and are released with the faeces to the external environment.Freshwater snails of the family Bithyniidae ingest the eggs and, following the release of the miracidia from the eggs, several stages of development take place within the snail until cercariae have developed.Shed cercariae can penetrate freshwater fish, where they encyst in the skin or flesh [3].
We experimentally demonstrate the fission of femtosecond pulses in a GRIN standard fiber, leading to high-energy multimode solitons that undergo huge Raman frequency shifts, and exhibit complex multisoliton dynamics.
The purpose of this article is to study border trade in the regions of Russia and the provinces of China. It is shown that in recent years there have been negative trends in border trade, leading to its reduction. Therefore, Russian regions bordering with China should transform into separate objects of regional policy, while also forming a legislative framework for border interaction in all its main spheres: trade, humanitarian cooperation, science and education, and others. In border cooperation with China, special emphasis should be placed on cooperation in the innovation sphere, as well as on improving the quality of exported goods and services and promoting infrastructure projects. Border trade between the regions of Russia and China is built mainly on trade and export of labour resources from China to Russia, as well as China’s receipt of additional sales channels for the confidently growing sales markets for consumer goods and sources of raw materials and primary products. The interaction of Russian regions with neighbouring provinces on the border with China not only preserves the raw material orientation of these regions, but also hinders the development and strengthening of the manufacturing industry in the structure of their regional economies, since border interaction for Russian regions immobilizes those stages of value-added production observed in the very first stages. In general, for the Chinese provinces there is a similar problem associated with such exports to border regions that have common borders with Russia, which does not contribute to the diversification and structural development of the regional economies of the Chinese provinces. That is why building an effective mechanism for border interaction between Russia and China is a strategically important issue for both countries.
A comparative electron-microscopic study of ultrastructure of mitochondria in skeletal muscles of the 3- and 24-month-old Wistar and OXYS rats revealed age-dependent changes in both general organization of the mitochondrial reticulum and ultrastructure of mitochondria. The most pronounced ultrastructure changes were detected in the OXYS rats suffering from permanent oxidative stress.

In the OXYS rats, significant changes in mitochondrial ultrastructure were detected already at the age of 3 months. Among them, there were the appearance of megamitochondria and reduction of cristae resulting in formation of cristae-free regions inside mitochondria. In the 24-month-old OXYS rats, mitochondrial reticulum was completely destroyed. In the isotropic region of muscle fiber, only small solitary mitochondria were present. There appeared regions of lysed myofibrils as well as vast regions filled with autophagosomes.

A mitochondrial antioxidant SkQ1 (given to rats with food daily in the dose of 250 nmol/kg of body weight for 5 months beginning from the age of 19 months) prevented development of age-dependent destructive changes in both the Wistar and OXYS rats.
Deltamethrin (DM) is a α- cyano pyrethroid insecticide used extensively in pest control. Although initially thought to be least toxic, a number of recent reports showed its toxicity in mammalian and non-mammalian laboratory and wildlife animal species.

The present study, carried out in male rats, is a contribution to explore some mechanisms underlying DM toxicity. The aim of the present research was to investigate the effect of different subcutaneous treatments with DM (2 ppm for 30 days, 20 ppm for 45 days and 200 ppm for 60 days) on testes histopathology, sex hormones and oxidative stress from male rats.

Our study mentioned an hypospermatogenesis within the testes accompanied by some apoptotic figures in particular cell fragments into the seminiferous tubules (ST)' lumen. The results obtained show that follicule-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone can be differently influenced in rats. In fact, findings of the present investigation mention a significant decrease (p ≤ 0.05) of FSH, LH and testosterone at the highest DM dose. Whereas a significant reduction of FSH was noticed after 45 days of treatment. The assessment of oxidative stress by malondialdehyde (MDA) measurements in plasma revealed a significant increase of this parameter after 30 days, 45 days or 60 days. In conclusion the study shows that subcutaneous DM treatment produces an arrest of spermatogenesis, a significant disharmony in sex hormones and MDA levels in rats that is related to dose, length of treatment and to the lipid peroxidation which may be one of the molecular mechanisms involved in DM-induced gonads toxicity.
Depth estimation has made great progress in the last few years due to its applications in robotics science and computer vision. Various methods have been implemented and enhanced to estimate the depth without flickers and missing holes. Despite this progress, it is still one of the main challenges for researchers, especially for the video applications which have more complexity of the neural network which af ects the run time. Moreover to use such input like monocular video for depth estimation is considered an attractive idea, particularly for hand-held devices such as mobile phones, they are very popular for capturing pictures and videos, in addition to having a limited amount of RAM. Here in this work, we focus on enhancing the existing consistent depth estimation for monocular videos approach to be with less usage of RAM and with using less number of parameters without having a significant reduction in the quality of the depth estimation.
The impact of fs and ns pulses on indium and sulfur doped gallium selenide crystals with four and five different doping concentrations, respectively, has been studied in comparison with that of undoped GaSe.

The inconsistence of the visual criterion of the damage threshold determination has been demonstrated. The multiphoton absorption and thermal effect have been identified as key factors limiting fs and ns pulse pump intensities, respectively.

High advantages in the limit pump intensity as up to 50% for optimally indium-doped crystal and up to 4.5 times for optimally sulfur-doped crystal have been demonstrated under fs pulses expose.
We calculate the electrostatic potential and electric field of a uniformly charged disk everywhere in space. This electrostatic problem was solved long ago, and its gravitational analogue - even earlier. However, it seems that physics students are not aware of the solution, because it is not presented in textbooks. The purpose of the present article is to fill this gap in the pedagogical literature.
We study intensity distribution of transmission resonances under the conditions of electromagnetically induced transparency (EIT) with lin||lin configuration in 87Rb vapor.

We demonstrate that for various orientations of the external magnetic field all seven resolved EIT resonances exhibit maxima or minima at certain directions of the linear polarization of the laser field.

This effect can be used for development of a high-precision vector EIT magnetometer.
Russell is a logical framework for the specification and implementation of deductive systems. It is a high-level language with respect to Metamath language [7], so inherently it uses a Metamath foundations, i.e. it doesn't rely on any particular formal calculus, but rather is a pure logical framework.

The main difference with Metamath is in the proof language and approach to syntax: the proofs have a declarative form, i.e. consist of actual expressions, which are used in proofs, while syntactic grammar rules are separated from the meaningful rules of inference. Russell is implemented in c++14 and is distributed under GPL v3 license.

The repository contains translators from Metamath to Russell and back. Original Metamath theorem base (almost 30 000 theorems) can be translated to Russell, verified, translated back to Metamath and verified with the original Metamath verifier.
The results of a comparative study of samples of the garden pea (Pisum sativum L.) by the main economically valuable traits are presented. The objects of the research were 13 breeding lines of peas of various morphotypes (leafy, semi-leafless, chameleon).

The experiment was conducted in 2016–2018 on leached chernozems in the northern forest-steppe of Western Siberia. The study period was characterized by contrasting weather conditions. Uneven precipitation was noted in 2016, which was higher than the norm in May, but below normal in June. In May 2017, the temperature and precipitation corresponded to the long-term average norm. Abundant rainfall from the period of sowing (the first ten-day period of May) to full ripeness (July) and low average daily air temperature in May characterized the vegetation period of 2018.

The best results in short-stalk characteristics and lodging resistance were reached by the line of the semi-leafless morphotype Nord × Az-318 (57.5 cm) and Orel × Yamal (57.7 cm). An average positive correlation was established between the height of the plant and the number of pods (r = 0.48 ± 0.20). By the mass of 1000 seeds the best results were shown by leafy lines (188.4 g) and the chameleon morphotype (181.1 g). Between the mass of 1000 seeds and the number of seeds in a pod, an average negative correlation was established (r = –0.63 ± 0.25). In terms of the yield, the chameleon morphotype lines (TM-1552, TM-1504) proved the most productive. The average yield of this morphotype was 280.0 g/m2, leafy lines – 271.4 g/m2 and the lines of the semi-leafless morphotype – 254.1 g/m2. A correlation was established between the yield and the studied traits. The yield is moderately positively affected by the number of seeds in a pod (r = 0.55 ± 0.20) and the number of pods in a plant (r = 0.50 ± 0.22). A significant yield advantage was not found between the studied breeding lines. For sustainable production of pea seeds, it is advisable to have a system of varieties of different morphotypes.
Актуальность исследованиясостоит в необходимости расширения минеральной сырьевой базы России. Восточное Забайкалье является одним из старейших золотодобывающих регионов страны. Тем не менее даже в таком хорошо изученном регионе остро стоит вопрос о поисках и обнаружении новых рудных месторождений. Для успешного выполнения такой задачи необходимы данные детального изучения уже известных рудных месторождений, которые могут быть использованы для разработки научно обоснованных критериев поиска рудных месторождений и прогноза оруденения. К таким данным относится определение источников рудоносных магматических расплавов, возраста и условий формирования золотого оруденения Александровского месторождения. Целью исследования является доказательство участия в рудообразовании нескольких магматических очагов с разными характеристиками на основании результатов изучения особенностей распределения редкоземельных элементов в магматических породах и рудах, изотопного состава кислорода рудоносного кварца и серы сульфидов, а также выявление физико-химических условий формирования оруденения с помощью исследования флюидных включений в минералах. Объектом исследования является Александровское золоторудное месторождение, расположенное в Восточном Забайкалье. Методы. Для определения элементного состав пород использовался рентгенфлуоресцентный метод и стандартный химический анализ, концентрации редкоземельных элементов измерялисьсорбционно-атомно-эмиссионным анализом с индуктивно-связанной плазмой (ГИН СО РАН, г. Улан-Удэ). Изучение изотопного состава серы сульфидов, содержаний Au и Ag, изотопного возраста (40Ar/39Ar) проведено в Центре коллективного пользования многоэлементных и изотопных исследований СО РАН (г. Новосибирск). Флюидные включения в кварце рудных жил изучены традиционными методами термобарогеохимии и методом КР-спектроскопии. Результаты. Определен возраст (40Ar/39Ar) синрудного серицита (162 ±2,3 млн лет), соответствующий возрасту интрузий амуджикано-шахтаминского комплекса. Установлено, что вариации изотопного состава кислорода рудоносного кварца, изотопов серы сульфидов соответствуют флюиду магматической природы. Анализ распределения редких и редкоземельных элементов указывает на то, что источниками оруденения были разноглубинные, в разной степени дифференцированные магматические очаги, функционировавшие как в верхней, так и в нижней континентальной коре. По данным исследования флюидных включений в кварце рудных жил, кристаллизация минеральных парагенезисов руд месторождения происходила в интервале температур от 150 до 402°С. Продуктивная минеральная ассоциация формировалась при температуре 402–360°С. Установлено участие в процессе рудообразования рудообразующих флюидов, различающихся по солевому составу, что указывает на разные условия генерации и природу рудообразующих флюидов. Отличительной особенностью месторождения является образование руд за счет разноглубинных, в разной степени дифференцированных рудоносных магматических источников.
In the paper, we consider a problem of clustering a finite set of N points in d-dimensional Euclidean space into two clusters minimizing the sum over all clusters of the intracluster sums of the distances between clusters elements and their centers.

The center of one cluster is defined as centroid (geometric center). The center of the other one is a sought point in the input set. We analyze the variant of the problem with the given clusters sizes.

We have proved the strong NP-hardness of this problem.
The need for blood circulation support systems in the treatment of chronic heart failure is constantly increasing as 20% of patients on the waiting list die every year. Despite the great need for mechanical heart support systems the use of available systems is limited by the high cost. Therefore, further research in the field of circulatory support systems is appropriate taking into account medical and technical requirements.

One of the new research areas is viscous friction disk pumps for transporting liquids based on the Tesla pump principle. The experimental model of LVAD disk pump is developed. Analytical dependencies are obtained to optimize the hydraulic parameters of the pump. On their basis, the experimental model of LVAD disk pump was designed and created.

The results of analytical and experimental studies of such a pump are presented.
Evolution of permafrost under thermokarst lakes is an actual question in the light of such problems of cryolythic zone research as greenhouse gas emission, permafrost degradation and cryovolcanism. Recently drained thermokarst lake provide an opportunity to study under-lake permafrost state with ground geophysical methods. This lake located on Kurungnakh island (composed of Yedoma ice complex deposits) in the Lena delta was studied with electrical resistivity tomography. Local low-resistivity anomaly in the central part of the lake was found during previous geophysical research.

Main goal of this work is detection of residual thermal effect from a frozen under-lake talik in an electric field. Satellite images of different years show that the drainage has taken place about 30 years ago. The area of the lake was covered in 2016 by high-resolution aerial imagery (5 cm/pixel), then digital elevation model was built using photogrammetry. These data were used for geomorphological description of the alas (depression in permafrost after lake drainage). The alas depth reaches 8 m, its size is about 300 × 500 m. It was formed probably on the last stage of Holocene thermokarst activity. Electrical resistivity tomography was implemented on 8 parallel profiles of 235 m. Measurements were conducted with dipole-dipole array. Basing on 3-dimensional inversion results a 3-dimensional resistivity model of under-lake deposits up to 40 m deep was made. 3-dimensional finite-element modeling of talik propagation (500 years) and refreezing (30 years) was done in axisymmetric setting taking phase transition into account.

Relatively low resistivity area (16–25 kOhm·m in comparison to 50–100 kOhm·m) was registered at the depth of 15–35 m. It is probably linked to a temperature anomaly (–3...–5 °С in comparison with –8.5 °С average value of the region). Therefore the under lake talik was fully frozen but the rest of temperature anomaly is still observable. Temperature anomaly up to 0 °С in its center at the depth of 35 m was obtained as a result of the modeling. It qualitatively confirms the interpretation of electrical resistivity tomography data on the residual temperature anomaly below the basin of the drained lake.
The Bacillus altitudinis strain KL4 was isolated from bottom sediments in Lake Krotovaya Lyaga (Novosibirsk Region, Russia, 53.7°N, 77.9°E). The sequenced and annotated genome is 3,738,419 bp long and carries 3,909 genes.
In this work an experimental study of the propagation of shock waves and pressure waves in a granular medium with selective properties was performed. A composite sorbent based on hollow glass microspheres with a selective- penetrable ability for helium is used as a granular medium. A special experimental setup was prepared using the shock tube principle. The installation includes a high-pressure section and a low-pressure section with a stepwise change in its inner diameter. Pressure plots were obtained for different tube sections for different media. The time of filling the pipe and the velocity of the pressure wave in the medium are estimated.
The mitochondria-targeted antioxidant SkQ1 is a novel drug thought to retard development of age-related diseases. It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. Our results showed that only AhR and AhR -dependent genes were sensitive to SkQ1. Dietary supplementation with SkQ1 decreased the AhR mRNA level in both OXYS and Wistar rats. At baseline, the retinal Cyp1a1 mRNA level was lower in OXYS rats. SkQ1 supplementation decreased the Cyp1a1 mRNA level in Wistar rats, but this level remained unchanged in OXYS rats. Baseline Cyp1a2 and Cyp1b1 mRNA expression was stronger in OXYS than in Wistar rats. In the OXYS strain, Cyp1a2 and Cyp1b1 mRNA levels decreased as a result of SkQ1 supplementation. These data suggest that the Cyp1a2 and Cyp1b1 enzymes are involved in the pathogenesis of AMD-like retinopathy of OXYS rats and are possible therapeutic targets of SkQ1.
under the conditions when evaporation is significant

We develop mathematical models of moving contact lines over flat heated solid surfaces with spatial variation of wetting properties. The gas phase is assumed to be pure vapor and a lubrication-type framework is employed for describing viscous flow in the liquid. Substrate wetting properties are modeled through disjoining pressure

with the main focus on how the contact line motion changes near the regions of localized spatial variation of wetting properties