Hengzongshu/ArticleAgent huggingface dataset:
The results of experimental and clinical trials of the agents based on oncolytic Newcastle disease virus (NDV) strains provided hope for the development of virotherapy as a promising method for treating human tumors. However, the mechanism of the antitumor effect of NDV and realization of its cytotoxic potential in a cancer cell remains to be elucidated.

In the current work, we have studied the antitumor effect of NDV in a syngeneic model of mouse Krebs-2 carcinoma treated with intratumoral injections of a wild-type strain NDV/Altai/pigeon/770/2011. Virological methods were used for preparation of a virus-containing sample. Colorimetric MTS assay was used to assess the viability of Krebs-2 tumor cells infected with a viral strain in vitro. In vivo virotherapy was performed in eight-week-old male BALB/c mice treated with serial intratumoral injections of NDV in an experimental model of Krebs-2 solid carcinoma. Changes in the tumor nodes of Krebs-2 carcinoma after virotherapy were visualized by MRI and immunohistological staining.

Light microscopy examination, immunohistochemical and morphometric analyses have shown that intratumoral viral injections contribute to the inhibition of tumor growth, appearance of necrosis-like changes in the tumor tissue and the antiangiogenic effect of the virus. It has been established that a course of intratumoral virotherapy with NDV/Altai/pigeon/770/2011 strain in a mouse Krebs-2 carcinoma resulted in increased destructive changes in the tumor tissue, in the volume density of necrotic foci and numerical density of endothelial cells expressing CD34 and VEGFR. These results indicate that intratumoral NDV injection reduces tumor progression of an aggressive tumor.
Three decades after the prediction of charge-vortex duality in the critical vicinity of the two-dimensional superconductor-insulator transition (SIT), one of the fundamental implications of this duality-the charge Berezinskii-Kosterlitz-Thouless (BKT) transition that should occur on the insulating side of the SIT-has remained unobserved. The dual picture of the process points to the existence of a superinsulating state endowed with zero conductance at finite temperature. Here, we report the observation of the charge BKT transition on the insulating side of the SIT in 10 nm thick NbTiN films, identified by the BKT critical behavior of the temperature and magnetic field dependent resistance, and map out the magnetic-field dependence of the critical temperature of the charge BKT transition. Finally, we ascertain the effects of the finite electrostatic screening length and its divergence at the magnetic field-tuned approach to the superconductor-insulator transition.
We present improved measurements of the branching fractions for the decays B0 --> Ds+pi- and B0-bar --> Ds+K- using a data sample of 657x10^6 BB-bar events collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.

The results are BF(B0 --> Ds+pi-) = (1.99 +/- 0.26 +/- 0.18)x10^-5 and BF(B0-bar --> Ds+K-) = (1.91 +/- 0.24 +/- 0.17)x10^-5, where the uncertainties are statistical and systematic, respectively.

Based on these results, we determine the ratio between amplitudes of the doubly Cabibbo suppressed decay B0 --> D+pi- and the Cabibbo favored decay B0 --> D-pi+, R_Dpi = [1.71 +/- 0.11(stat) +/- 0.09(syst) +/- 0.02(theo)]%, where the last term denotes the theory error.
We present first evidence showing that some electrophoretically homogeneous IgGs from the sera of patients with schizophrenia (36.4%) and their Fab and F(ab)2 fragments as well as from healthy donors (33.3%) possess catalase activity. The relative catalase activity of IgGs from the sera of individual schizophrenia patients (and healthy donors) significantly varied from patient to patient, but the activity of IgGs from healthy donors is on average 15.8-fold lower than that for schizophrenia patients. After extensive dialysis of purified IgGs against EDTA chelating metal ions, the relative catalase activity of IgGs decreases on average approximately 2.5–3.7-fold; all IgGs possess metal-dependent and independent catalase activity. The addition of external Me2+ ions to dialyzed and non-dialyzed IgGs leads to a significant increase in their activity. The best activator of dialyzed and non-dialyzed IgGs is Co2+, the activation by Cu2+, Mn2+, and Ni2+ ions were rare and always lower than by Co2+. Every IgG preparation demonstrates several individual sets of very well expressed pH optima in the pH range from 4.0 to 9.5. These data speak for the individual repertoire of catalase IgGs in every person and an extreme diversity of abzymes in their pH optima and activation by different metal ions. It is known that antioxidant enzymes such as superoxide dismutases, catalases, and glutathione peroxidases represent critical defense mechanisms preventing oxidative modifications of DNA, proteins, and lipids. Catalase activity of human IgGs could probably also play a major role in the protection of organisms from oxidative stress and toxic compounds.
A physical and mathematical model of detonation of aluminum particle gas suspensions of in a wide range of particle sizes from several micrometers to tens of nanometers is presented. In the description of transport properties of particles in the flow and interphase heat transfer, the transition from the continuum regime to the free-molecular regime is considered.

The description of aluminum particle combustion is based on the reduced Arrhenius-type kinetics. We take into account the transition from the diffusion type of combustion of large particles to the kinetic type for particles smaller than 1 micrometer. The reaction constants were obtained from the data of experiments on the dependence of the burning time of nano-sized particles on the temperature and pressure of the surrounding gas and the particle diameter.

Examples of Chapman-Jouguet detonation structures are given. The boundaries of the applicability of the continual description of thermal dynamics in the detonation of particle suspensions in gas are determined.
This article attempts to study changes in the microstructure of solid solutions with the perovskite structure La0.5Ca0.5Mn0.5Fe0.5O3 under the action of the methane oxidation reaction medium. By the methods of XRD, XPS and HRTEM the initial condition of the structure and the surface of the perovskite were both investigated. A feature of the structure of this solid solution is the presence of planar defects in the direction of the planes (101). After the methane oxidation reaction, a similar study of perovskite structure was conducted to obtain the changes. It was shown that under the action of the reaction medium, Ca1−xMnxO particles form on the surface of the perovskite phase, while planar defects in La0.5Ca0.5Mn0.5Fe0.5O3 structure remain. In situ XRD experiments on perovskite calcination in helium current up to 750 °C showed the formation of a similar Ca1−xMnxO phase on the perovskite surface.
We propose a representation of the virtual braid group V Bn into the automorphism group of a free product of a free groups and a free Abelian groups.V. G. Bardakov, Yu. A. Mikhalchishina and M. V. Neshchadim proposed a representation φM of the virtual braid group V Bn into the automorphism group of a free product of a free group and a free Abelian group.Our representation generalizes this representation φM .It is proved that the kernel of new representation is contained in the kernel of representation φM .It is proved that natural genetic code of image of the virtual braid group V Bn with respect to new representation has strong symmetry.
The asymmetry in the production cross-section σ of D+/- mesons, A_P = (σ(D+) - σ(D-))/(σ(D+) + σ(D-)), is measured in bins of pseudorapidity η and transverse momentum p_T within the acceptance of the LHCb detector.

The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider.

When integrated over the kinematic range 2.0 < η < 4.8, the production asymmetry is A_P = (-0.96 ± 0.26 ± 0.18)%, which is consistent with zero at the 3σ level. The possibility of a physics asymmetry in the D+ -> K_S pi+ decay is negligible. No significant dependence on η or p_T is observed.
The results of numerical investigation of the ignition of a stoichiometric methane-air mixture in the presence of carbon particles with diameters of 20-52 μm in the temperature range 950-1150 K and pressures of 1.5-2.0 MPa are presented. The calculated data of the ignition delay times of coal particles in the coal particles/air mixture and of the ignition delay times of methane and coal particles in the methane/coal particles /air mixture are compared with the experimental ones. A satisfactory agreement of the data on the coal particles ignition delay times and methane ignition delay times in all the mixtures considered is shown.
Environmental aspects are an essential part of economic development. Improvement of the environmental situation can have a significant impact on the pace and structure of economic development. For environmental component, it is important to analyze the current state and predict greenhouse gas emissions.

The development of methodological approaches in this area will allow for more detailed forecasting of the situation. In order to reduce the emission of greenhouse gases, European countries have set targets for efficiency of energy consumption and widespread use of renewable energy sources.

By 2020, the goal is set for energy consumption to be at least 20% from renewable sources. According to the forecast on average, in 2040 the share of oil products in the structure of fuel consumption in road transport in Europe will be reduced to 80%. Nevertheless, in the countries of Europe, various trends in the field of greenhouse gas emissions are expected. Most countries have a high potential for reducing greenhouse gas emissions from fuel combustion on road vehicles. In Russia, emissions from vehicles are projected to reduce by 8% by 2040.
On the BETA facility, an electron beam is used for simulation of pulsed thermal loads on ITER-relevant tungsten.

Numerical experiments are used for verification of the models. This paper presents extension of the model of electron beam heating, supplemented with dynamics of gas evaporation from a heated surface in vacuum.
The TaHOX-1 gene of common wheat Triticum aestivum L. (BAD-genome) encodes transcription factor (HD-Zip I) which is characterized by the presence of a DNA-binding homeodomain (HD) with an adjacent Leucine zipper (LZ) motif. This gene can play a role in adapting plant to a variety of abiotic stresses, such as drought, cold, salinity etc., which strongly affect wheat production. However, it's both functional role in stress resistance and divergence during wheat evolution has not yet been elucidated.

This data in brief article is associated with the research paper 'Structural and functional divergence of homoeologous copies of the TaHOX-1 gene in polyploid wheats and their diploid ancestors'. The data set represents a recent survey of the primary HOX-1 gene sequences isolated from the first wheat allotetraploids (BA-genome) and their corresponding Triticum and Aegilops diploid relatives. Specifically, we provide detailed information about the HOX-1 nucleotide sequences of the promoter region and both nucleotide and amino acid sequences of the gene.

The sequencing data used here is available at DDBJ/EMBL/GenBank under the accession numbers MG000630-MG000698.
In this work, the piezoresistive properties of polymer-graphene composites were investigated.

The electrical resistance of these samples ranged from 693 to 1277 Ohm/sq for single-layer graphene coating, and from 477 to 1096 Ohm/sq for multilayer coating. It was shown that with a tensile strain of 4%, the maximum gauge factor was 100. For bending with a radius of curvature of 70 mm, which corresponds to a stretch of 0.75%, the maximum gauge factor was 34.

It is shown that samples with a single-layer graphene coating are more resistant to deformation processes – their electrical resistance changes less than in samples with a multilayer graphene coating. Such a phenomenon can be associated with an increased concentration of defects and imperfections in graphene structures, which, in the case of a multilayer coating, leads to lower strength of the entire structure and much more destructive consequences in tension. A multilayer coating can have a heterogeneous structure: individual multilayer islands can be connected by single-layer sections. The gap between the latter leads to a significant drop in the electrical resistance of the entire sample.
The article considers the possibility of calculating indicators of the theoretical cost category using modern inter-industry interregional tools for forecasting economic development. The principles of displaying production relationships implemented in them and the resulting calculated indicators in the cost dimension do not contradict the categories of classical political economy. In parallel, the concept of redistribution of nominal value by means of Finance between interconnected producers and consumers was introduced when applying the intersectoral approach. The paper provides an example of calculations. The usual financial statements are used as an instrumental basis, but the number of employees is set as an input measure of all costs. As a result, all calculated data: prices (aggregated prices), indices of their changes in dynamics, current financial flows are recalculated in labor costs. The tables below represent the corresponding indicators aggregated by region. Despite the proximity of the financial and cost categories, the use of cost characteristics in financial instruments to calculate them affects the quantitative results to a certain extent. In particular, comparison of indicators of forecasts of financial and cost statements of tasks connected with one initial base of tasks of material composition shows the following. The dynamics of changes in the total income of the population, budgets, volume of loans, etc. for indicators in value units are overwhelmingly lower than the corresponding values of the mentioned purely financial task. This suggests that the rates calculated in current prices (the financial task) have a greater inflationary impact than similar indicators calculated in value units. Or, regional differentiation of calculated units of product value above the corresponding indices of consolidated prices of purely financial statements. To a certain extent, this is due to the fact that the task adopted assumptions for a certain alignment of economic activity conditions by region due to the differentiation of Federal taxes.
Operation of a plasma source with a hot disk cathode and a cylindrical hollow anode in axial magnetic field is sensitive to the cathode-to-anode diameter ratio.

When the cathode edge maps along magnetic field lines to the inner anode surface, the discharge voltage is relatively low, and the plasma stream with moderate density occupies the entire cross-section of the anode bore. By contrast, when the cathode projection is fully inside the anode bore with the radial cathode-to-anode gap ∼ 1 cm, the discharge voltage jumps to much higher values exceeding 250 V. The plasma density profile becomes Gaussian-like with the width matching the cathode radius according to magnetic flux surfaces. The plasma density in the high-voltage cross-field discharge reaches 1013 cm−3, and the discharge parameters almost do not change with magnetic field up to 1.5 kG in the anode area.

This plasma source is suitable for the use in linear devices for plasma-material interaction studies.
Polycrystalline silicon (poly-Si) thin films were obtained by aluminium induced crystallisation of amorphous silicon suboxide (a-SiO x , x = 0.22)

via annealing of a-SiO 0.22 /Al bilayer structures at 550 °C for 4 - 30 h. The a-SiO 0.22 /Al thickness ratio was approximately 1. According optical microscopy measurements, the crystallized fraction reached the saturation value of 85% after annealing for 20 h. X-ray diffraction measurements

The further increase in the annealing time didn't lead to an increase in this value. The formed poly-Si had a strong Si (111) preferred orientation.
Irradiation of the Keggin-type [PW11O39{Ru(NO)}]4− (Ru-NO) polyoxometalate in CH3CN results in rapid NO ligand elimination with the formation of [PW11O39{RuIII(CH3CN)}]4− (Ru-CH3CN).

UV-VIS, CV, and HR-ESI-MS techniques were used for the reaction monitoring and characterization of the products.

This complex offers an easy entry into the Ru-based chemistry of the {PW11Ru} complex. Attempts to substitute N3− for CH3CN in the presence of an NaN3 excess lead a variety of products: (i) [PW11O39{RuIII(N3)}]4− (Ru-N3); (ii) [PW11O39{RuIII(N4HC-CH3)}]4− (Ru-Tz) as a click-reaction product; and (iii) [PW11O39{RuII(N2)}]5− (Ru-N2).
The parasitic plant Striga hermonthica invades the host root through the formation of a haustorium and has detrimental impacts on cereal crops. The haustorium is derived directly from the differentiation of the Striga radicle. Currently, how Striga root cell lineages are patterned and the molecular mechanisms leading to radicle differentiation shortly after germination remain unclear.

In this study, we determined the developmental-morphodynamic programs that regulate terminal haustorium formation in S. hermonthica at spatiotemporal and cellular resolutions. We showed that in S. hermonthica roots, meristematic cells first undergo multiplanar divisions, which decrease during growth and correlate with reduced expression of the stem cell regulator PLETHORA1. We also found that PIN-FORMED (PIN) proteins undergo a shift in polarity. Using the layout of the root structure and the polarity of outer-membrane PIN proteins, we constructed a mathematical model of auxin transport that explains the auxin distribution patterns observed during S. hermonthica root growth.

Our results reveal a fundamental molecular and cellular framework governing the switch of S. hermonthica roots from the vegetative to the invasive state by inducing meristem differentiation through auxin excretion to the environment and explain how asymmetric PIN polarity controls auxin distribution to maintain meristem activity and sustain root growth.
Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe3O4) were fabricated by electrospinning.

The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe3O4 scaffolds submicron-sized Fe3O4 particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio-0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C.

The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the decrease in melting temperature to 168-169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe3O4). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candidates for usage in biomedical applications.
In this work we calculated energy and magnetic characteristics for multilayer ferromagnetic structure Co/Cu[100] by VASP on POWER architecture.

We analyzed performance of the VASP package on the OpenPOWER HPC system with several Pascal P100 GPU units in compare with calculation on POWER8 CPU only and on a system with Intel architecture.

We revealed that the VASP calculations achieve maximum performance on OpenPOWER System with the GPUs.
The article analyses the way the quality of institutions affects the performance of energy saving policies. Based on the analysis of dynamic panel data for 69 countries over the period from 2002 to 2012, using Arellano-Bond approach, we have shown that the elasticity of energy consumption by price of energy depends on institutional factors. We also demonstrated that absolute values of the said indicators are higher in OECD than CIS countries over the whole data sample, which is explained by a higher quality of institutions. Similar valuations and calculations have been produced for the industrial sector as well as the production sphere. The energy consumption in the industrial sector has proved to be more sensitive to the quality of institutions than in production sphere as a whole. We have also performed a general analysis of trends of GDP energy consumption for a number of countries pointing out that a growth of energy prices enhances energy saving processes.Keywords: energy intensity, cross-country analysis, Arellano-Bond approach.JEL Classifications: D02, E02, Q43DOI: https://doi.org/10.32479/ijeep.8259
Maturity onset diabetes of the young (MODY) is a congenital form of diabetes characterized by onset at a young age and a primary defect in pancreatic-β-cell function. Currently, 14 subtypes of MODY are known, and each is associated with mutations in a specific gene: HNF4A, GCK, HNF1A, PDX1, HNF1B, NEUROD1, KLF11, CEL, PAX4, INS, BLK, KCNJ11, ABCC8, and APPL1. The most common subtypes of MODY are associated with mutations in the genes GCK, HNF1A, HNF4A, and HNF1B. Among them, up to 70% of cases are caused by mutations in GCK and HNF1A. Here, an analysis of 14 MODY genes was performed in 178 patients with a MODY phenotype in Western Siberia. Multiplex ligation-dependent probe amplification analysis of DNA samples from 50 randomly selected patients without detectable mutations did not reveal large rearrangements in the MODY genes. In 38 patients (37% males) among the 178 subjects, mutations were identified in HNF4A, GCK, HNF1A, and ABCC8. We identified novel potentially causative mutations p.Lys142*, Leu146Val, Ala173Glnfs*30, Val181Asp, Gly261Ala, IVS7 c.864 −1G>T, Cys371*, and Glu443Lys in GCK and Ser6Arg, IVS 2 c.526 +1 G>T, IVS3 c.713 +2 T>A, and Arg238Lys in HNF1A.