Hengzongshu/ArticleAgent huggingface dataset:
It is well known that the early life experiences affect stress responses and other physiological and behavioral traits in adulthood. Both rat and human studies have shown that early postnatal effects are associated with methylation of the hippocampal glucocorticoid receptor gene exon 1 7 (rat) and 1‐F (human) promoters. Methylation of these sites is also seen following methionine administration in adult rats. However, it remains unclear whether similar alterations in DNA methylation profiles can result from prenatal influences. To address this question, we fed pregnant rats a methyl‐supplemented diet that resulted in alteration of the stress response. However, methylation analysis revealed no effect of methyl supplements on methylation patterns of the glucocorticoid receptor gene exon 1 7 promoter in offspring. These results suggest that the pre‐ and postnatal effects of methyl supplementation have different mechanisms.
In the present work a computer code RCFS for numerical simulation of chemically reacting compressible flows on hybrid CPU/GPU supercomputers is developed.

It solves 3D unsteady Euler equations for multispecies chemically reacting flows in general curvilinear coordinates using shock-capturing TVD schemes. Time advancement is carried out using the explicit Runge-Kutta TVD schemes. Program implementation uses CUDA application programming interface to perform GPU computations. Data between GPUs is distributed via domain decomposition technique.

The developed code is verified on the number of test cases including supersonic flow over a cylinder.
A genetic locus suppressing DNA underreplication in intercalary heterochromatin (IH) and pericentric heterochromatin (PH) of the polytene chromosomes of Drosophila melanogaster salivary glands, has been described.

Found in the In(1)sc V2 strain, the mutation, designated as Su(UR)ES , was located on chromosome 3L at position 34.8 and cytologically mapped to region 68A3-B4. A cytological phenotype was observed in the salivary gland chromosomes of larvae homozygous and hemizygous for Su(UR)ES : ( i ) in the IH regions, that normally are incompletely polytenized and so they often break to form "weak points," underreplication is suppressed, breaks and ectopic contacts disappear; ( ii ) the degree of polytenization in PH grows higher. That is why the regions in chromosome arm basements, normally β-heterochromatic, acquire a distinct banding pattern, i.e., become euchromatic by morphological criteria; ( iii ) an additional bulk of polytenized material arises between the arms of chromosome 3 to form a fragment with a typical banding pattern. Chromosome 2 PH reveals additional α-heterochromatin. Su(UR)ES does not affect the viability, fertility, or morphological characters of the imago, and has semidominant expression in the heterozygote and distinct maternal effect.

The results obtained provide evidence that the processes leading to DNA underreplication in IH and PH are affected by the same genetic mechanism.
Aim. To establish associations of the frequency of detection of clusters and components of the metabolic syndrome (MS) with the prevalence of depression in open male population of moderately urbanized Siberian city. Material and methods. Cross-sectional epidemiological survey included 1000 individuals formed from the election list of males in one of the Tyumen administrative districts. The response rate was 85,0%. MS was assessed using the International Diabetes Federation (IDF) criteria. A self-administered WHO MONICA-psychosocial questionnaire was used to assess the levels of depression. Statistical analysis was conducted using a package of software program for medical data IBM SPSS Statistics 21.0. Results. In the open population of moderately urbanized Siberian city in men (age 25-64) with depression the following clusters of MS are prevalent: abdominal obesity (AO) + hypertriglyceridemia (HTG) + decrease of high-density lipoprotein cholesterol (hypoHDL-C) and AO + hypoHDL-C + arterial hypertension (AH); in the presence of a high level of depression AO + HTG + hypoHDL-C and AO + hypoHDL-C + AH are prevalent. A direct correlation was established between the prevalence of depression and abdominal obesity and hypertension, as well as the prevalence of a high level of depression with HTG and hypo-HDL cholesterol. In the open urban population in men (age 25-64) with high level of depression the following clusters of MS are prevalent: AO + HTG + hypoHDL-C and AO + HTG + hypoHDL-C + AH. We established an increase in the chances of developing a high level of depression with following MS clusters: AO + HTG + hypoHDL-C. According to IDF criteria, the prevalence of MS components in male population (age 25-64) in Tyumen was: AO — 42,6%; AH — 59,8%; hyperglycemia — 17,4%; HTG — 10,5%; hypoHDL-C — 4,6%. With a primary prevalence of MS components in men (age 25-64) with a low level of depression, the prevalence of HTG and hypoHDL-C in open population of moderately urbanized Siberian city prevails in men with high and mean levels of depression. Conclusion. The strategies for MS prevention in men of moderately urbanized city should contain measures to optimize nutrition regarding psychosocial determinants. This is due not only to the wide prevalence of overweight and obesity in Tyumen population but also to dyslipidemia associated with these factors.
The problem of data fusion from data bases and knowledge graphs in different languages is becoming increasingly important. The main step of such a fusion is the identification of equivalent entities in different knowledge graphs and merging their descriptions. This problem is known as the identity resolution, or entity alignment problem. Recently, a large group of new entity alignment methods has emerged. They look for the so called 'embeddings' of entities and establish the equivalence of entities by comparing their embeddings.

This paper presents experiments with embedding-based entity alignment algorithms on a Russian-English dataset.

The purpose of this work is to identify language-specific features of the entity alignment algorithms. Also, future directions of research are outlined.
Exosomes are directly involved in governing of physiological and pathological conditions of an organism through the transfer of information from producing to receiving cells. It can be assumed that exosomes are one of the key players of tumor dissemination since they are very stable and small enough to penetrate from various tissues into biological fluids and then back, thus interacting with tissue target cells.

We evaluated the enzymatic activity and the level of 20S proteasome in tissue and exosomes of healthy females (n = 39) and patients with ovarian (n = 50) and breast (n = 108) tumors to reveal the critical role of exosomal cargo in the mediation of different types of metastases. Exosomes from plasma and ascites were isolated and characterized in according to International Society for Extracellular Vesicles guidelines. The level of 20S proteasome in tissue and exosomes was determined using Western blot analysis. Chymotrypsin- and caspase-like (ChTL and CL, respectively) peptidase activities of the proteasomes were determined using fluorogenic Suc-LLVY-AMC and Cbz-LLG-AMC substrates, respectively.

We observed increased levels of 20S proteasome in ovarian cancer tissue and luminal B subtype breast cancer tissue as well as in plasma exosomes from cancer patients. Moreover, the level of the 20S proteasome in plasma exosomes and ascites exosomes in patients with ovarian tumors is comparable and higher in ovarian cancer patients with low volume ascites than in patients with moderate and high-volume ascites. We also found increased ChTL and CL activities in breast cancer and ovarian cancer tissues, as well as in peritoneal metastases in ovarian cancer, while proteasomal activity in exosomes from plasma of healthy females and all patients, as well as from ascites of ovarian tumor patients were lower than detection limit of assay. Thus, regardless of the type of tumor metastasis (lymphogenous or peritoneal), the exosomes of cancer patients were characterized by an increased level of 20S proteasome, which do not exhibit enzymatic activity.
TBAClO4 has a polymorphous transition at 330 K and melts at 487 K. The structure of the high-temperature (HT) phase belongs to cubic symmetry and is similar to the HT phases of TBABF4 and TBAI salts.

The thermal parameters of the phase transitions and transport properties of tetra-n-butylammonium (TBA) perchlorate (n-C4H9)4NClO4 (TBAClO4) were investigated. The conductivity parameters of the low-temperature and HT phases of TBAClO4 were determined from the Arrhenius plots. The thermodynamic parameters and transport properties of TBAClO4 were compared with those of other TBA salts having isostructural HT phases.

The polymorphous phase transition entropy was found to correlate with the conductivity of HT phases of TBA salts; TBAClO4 has the lowest conductivity compared to TBABF4 and TBAI salts.
The article analyzes the main stages of the formation of inter-fuel competition. A statistical analysis of changes in the fuel and energy balance at the global and regional levels has been performed. The key factors contributing to inter-fuel competition at the present stage of development of energy markets are highlighted.
The data on the evolution of the interface at the sudden injection of gas from a long tube into a liquid column was obtained. High speed video of experiments and calculations in OpenFoam software package were used as research methods. Investigations were performed for different initial pressures. Typical configurations of the interface for different time periods were shown both experimentally and numerically.
At present great attention is paid to studying genetic regulation of farm animal adaptations to environmental conditions. This problem is very important due to a wide expansion of highly productive cattle breeds created in Europe and North America. However, until the present no investigation of changing semen quality in bulls of imported breeds during their adaptations to environmental conditions of Western Siberia has been conducted. The aim of this study was to investigate semen quality peculiarities and the diversity of morphological sperm abnormalities in bulls of imported and local breeds kept in the environmental conditions of the southern part of Western Siberia. We determined sperm concentration, sperm count, and rate of sperm with progressive motility and percentage of morphologically normal spermatozoa. The rate of sperm abnormalities according to Blome’s classifcation was determined too. It was found that the mean values of sperm concentration, sperm motility and percentage of morphologically normal spermatozoa in the bulls investigated were similar to those in bulls kept in European countries. Inter­breed diﬀerences in these parameters were not found. However, bulls of the Red Danish, Angler, and Simmental breeds had a higher percentage of misshapen sperm head and pyriform sperm head than bulls of the Black­White breed. An inter­strain diﬀerence in sperm motility in bulls of the Black­White breed was observed. It was found that bulls of Reﬂection Sovereign 198998 strain had lover sperm motility than bulls of Wis Burke Ideal 1013415 strain. No inter­strain diﬀerences in sperm production, percentage of morphologically normal spermatozoa and rate of main sperm abnormalities were found. Thus, it has been found that the environmental conditions of the southern part of Western Siberia do not seriously aﬀect the sperm production, sperm motility or percentage of morphologically normal spermatozoa in bulls. However, the increased rate of misshapen and pyriform sperm heads in the bulls of the foreign breeds points to a need to study sperm DNA fragmentation.
Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-topoisomerase 1 (TOP1) stabilized by the TOP1 inhibitor topotecan, neutralizing the effect of the drugs. TDP1 removes damage at the 3′ end of DNA caused by other anticancer agents. Thus, TDP1 is a promising therapeutic target for the development of drug combinations with topotecan, as well as other drugs for cancer treatment.

Ten new UA enamino derivatives with variation in the terpene fragment and substituent of the UA backbone were synthesized and tested as TDP1 inhibitors. Four compounds, 11a-d, had IC50 values in the 0.23–0.40 μM range. Molecular modelling showed that 11a-d, with relatively short aliphatic chains, fit to the important binding domains. The intrinsic cytotoxicity of 11a-d was tested on two human cell lines.

The compounds had low cytotoxicity with CC50 ≥ 60 μM for both cell lines. 11a and 11c had high inhibition efficacy and low cytotoxicity, and they enhanced topotecan’s cytotoxicity in cancerous HeLa cells but reduced it in the non-cancerous HEK293A cells. This “protective” effect from topotecan on non-cancerous cells requires further investigation.
The results of the study of the land surface temperature regime of the Novosibirsk region for cartographic modeling based on satellite sensing data are presented.
We report on our direct experimental observation of a new regime of operation of passively mode-locked fibre lasers where the laser oscillator generates pulsating solitons with extreme ratios of maximal to minimal intensities in each period of pulsations. The soliton spectra also experience large periodic broadening and compression. Spatio-temporal intensity and dispersive Fourier-transformation measurements enable us to capture such transient dynamics in real time.
It is demonstrated that the performance of the self-modulated proton driver plasma wakefield accelerator (SM-PDPWA) is strongly affected by the reduced phase velocity of the plasma wave.

Using analytical theory and particle-in-cell simulations, we show that the reduction is largest during the linear stage of self-modulation. As the instability nonlinearly saturates, the phase velocity approaches that of the driver.

The deleterious effects of the wake's dynamics on the maximum energy gain of accelerated electrons can be avoided using side-injections of electrons, or by controlling the wake's phase velocity by smooth plasma density gradients.
The problem of quantum turbulence in a channel with an inhomogeneous counterflow of superfluid turbulent helium is studied. \ The counterflow velocity $V_{ns}^{x}(y)$ along the channel is supposed to have a parabolic profile in the transverse direction $y$. Such statement corresponds to the recent numerical simulation by Khomenko et al. [Phys. Rev. B \textbf{91}, 180504 (2015)]. The authors reported about a sophisticated behavior of the vortex line density (VLD) $\mathcal{L}(\mathbf{r},t)$, different from $% \mathcal{L}\propto V_{ns}^{x}(y)^{2}$, which follows from the naive, straightforward application of the conventional Vinen theory. It is clear, that Vinen theory should be refined by taking into account transverse effects and the way it ought to be done is the subject of active discussion in the literature. In the work we discuss several possible mechanisms of the transverse flux of VLD $\mathcal{L}(\mathbf{r},t)$ which should be incorporated in the standard Vinen equation to describe adequately the inhomogeneous quantum turbulence (QT). It is shown that the most effective among these mechanisms is the one that is related to the phase slippage phenomenon. The use of this flux in the modernized Vinen equation corrects the situation with an unusual distribution of the vortex line density, and satisfactory describes the behavior $\mathcal{L}(\mathbf{r},t)$ both in stationary and nonstationary situations. The general problem of the phenomenological Vinen theory in the case of nonuniform and nonstationary quantum turbulence is thoroughly discussed.
The paper suggests and investigates a problem statement of well-logging inverse problem that is based on the integral conductivity parameter to describe a geoelectric section. Approach was introduced for a layered cylindrical model with radially heterogeneous continuous distribution of electric properties that parametrize the problem with a function of total longitudinal conductivity. The results of hydrodynamic modeling for oil/fresh water- and brine-based drilling muds were used to study multiple propagation resistivity tool signal equivalency for two classes of models with continuous and piece-wise constant conductivity distribution. Physically based algorithm enabling one to convert one model class to the other, preserving the signal equivalency was proposed. It was demonstrated that the radial models with different radial conductivity distribution and similar integral conductivity curves are equivalent. This fact lays a rationale of using the integral conductivity parameters along with conductivity while inversion. The integral conductivity parameter can be used to build the functionals, whose minimization improves algorithm stability and enables determining functional parameters in hydrodynamic filtration models.
The method of experiments with internal targets in the storage ring was proposed at the moment of creation of the first storage ring of charged particles. This method has demonstrated dramatic advances during the last 50 years. The most clearly visible progress can be seen in experiments with polarized gas targets. In this report we shall review: (a) the experiments on nuclear physics in the storage rings on the measure of polarization observables in different reactions with electron/positron and proton/deuteron beams, (b) the use of polarized gas targets in the storage ring for polarimetry of the circulated beams. The present status of the activity in this field of experimental physics is given.
We studied cavitating flow over the suction side of a symmetric 2D foil – a scaled-down model of high-pressure hydroturbine guide vanes (GV) – in different cavitation regimes at the attack angle of 3°. High-speed imaging was used to analyze spatial patterns and time dynamics of the gas-vapour cavities. A hydroacoustic pressure transducer was employed to register time-spectra of pressure fluctuations nearby the hydrofoil. A PIV technique was applied to measure the velocity fields and its fluctuations. The active flow control was implemented by means of a continuous liquid supply with different flow rates through a slot channel located in the GV surface. It was found that the active mass injection does not influence the primary flow upstream of the slot channel position. For the cavitation-free and cavitation inception cases, the injection was shown to make the turbulent wake past the GV section more intense. However, at the developed cavitation regimes the active flow management made it possible to reduce substantially the amplitude or even totally suppress the periodic cavity length oscillations and pressure pulsations associated with them.
Эталонные для скифо-сакского мира вещи предметного комплекса из погребальных памятников раннесакской культуры VII-VI вв.до н.э.за последние десятилетия дополнились не менее значительными находками.

В представленной работе рассматриваются случайные находки бронзовых предметов воинской поясной гарнитуры и детали конского снаряжения раннего этапа сакской культуры из Восточного
A plane circular LaB6 cathode and a hollow anode are used for the arc discharge plasma production in a newly developed linear plasma device with the axially symmetric magnetic field. The cathode is heated by radiation from a graphite foil flat spiral.

A separately powered magnetic coil located around the plasma source is used to vary the radial distance between the outermost magnetic field line from the cathode and the inner anode surface. The discharge geometry defines distinct operational modes: partially direct discharge and magnetic insulation. The magnetic field in the source can be varied from 0 to 2.4 kG while preserving the chosen field geometry, with the discharge voltage and current depending on the particular mode.

A hydrogen plasma stream with a density of up to 1·1013 cm−3 and a diameter of about 4 cm is produced. The discharge characteristics and the plasma parameters do not change significantly between the two modes and in a relatively broad range of magnetic fields.
Several experimental groups observed temporary modulations of some nuclei strong and weak decay constants, which are of the order of 10 −3 and with periods of one year, solar day, i.e. 24 hours and some others. In our experiments the decay rates were measured for 55 Fe e-capture and 60 Co β -decay during 2012–2020. Altogether, six decay rate dips of the order 10 −2 – 10 −3 and with duration from 40 to 208 hours were found, they deviate essentially from exponential decay rate fit. It is shown that their occurrence correlate with x-ray solar flares with significant reliability. Besides, two long term deviations of 55 Fe decay rate of 62 and 41 days were observed in 2017–2018, it’s argued that they are related to the change of 11 year solar cycle stages.
Our aim was to study the effect of depression and social support on the risk of type 2 diabetes in female population aged 25-64 in Russia / Siberia.

Under the screening surveys random representative samples of women aged 25-64 years were examined in 1994 and 2005. Depression assessment was performed using the MONICA- MOPSY test. Social support was measured using the Berkman-Sim test. From 1994 to 2018 in a cohort of women new-onset cases of diabetes mellitus were detected.

The risk of T2DM in persons with depression was 1.844 (p<0.01). After adjusting for sociodemographic variables, the risk decreased by 6% but remained significantly significant (p <0.05). The impact of a low level of social relations showed a significant effect on the risk of diabetes mellitus, including the multivariate model adjusted for the social gradient (HR=1.833, p<0.05). The presence of psychosocial factors decreases the protective effect of education in diabetes incidence. The incidence of T2D was higher in the group of manual labor and in executives. Depression and low social support increase the risk of T2DM by 80%. The frequencies of T2DM are determined by the social gradient and are associated with the role conflict 'family-work'.
The electron attachment effect on DBD characteristics in chlorine and its mixtures with xenon has been studied.

Characteristics of the DBDs in pure chlorine and in xenon-chlorine mixtures with a chlorine fraction of 0.1-5% were modeled using the fluid model.

It is shown that the electron attachment limits a magnitude of the DBD current, contributes to formation of multiple current spikes, appearance of a double layer near the dielectric surface and formation of XeCl* excimer molecules, and leads to a redistribution of the power deposited into the discharge: more power is deposited into ions and less power is deposited into electrons.