Hengzongshu/ArticleAgent huggingface dataset:
Non-long terminal repeat (non-LTR) retrotransposons are mobile genetic elements that propagate themselves by reverse transcription of an RNA intermediate. Non-LTR retrotransposons are known to evolve mainly via vertical transmission and random loss. Horizontal transmission is believed to be a very rare event in non-LTR retrotransposons. Our knowledge of distribution and diversity of insect non-LTR retrotransposons is limited to a few species – mainly model organisms such as dipteran genera Drosophila, Anopheles, and Aedes. However, diversity of non-LTR retroelements in arthropods seems to be much richer.

The present study extends the analysis of non-LTR retroelements to CR1 clade from four butterfly species of genus Maculinea (Lepidoptera: Lycaenidae). The lycaenid genus Maculinea, the object of interest for evolutionary biologists and also a model group for European biodiversity studies, possesses a unique, specialized myrmecophilous lifestyle at larval stage. Their caterpillars, after three weeks of phytophagous life on specific food plants drop to the ground where they are adopted to the ant nest by Myrmica foraging workers. We found that the genome of Maculinea butterflies contains multiple CR1 lineages of non-LTR retrotransposons, including those from MacCR1A, MacCR1B and T1Q families. A comparative analysis of RT nucleotide sequences demonstrated an extremely high similarity among elements both in interspecific and intraspecific comparisons.

CR1A-like elements were found only in family Lycaenidae. In contrast, MacCR1B lineage clones were extremely similar to CR1B non-LTR retrotransposons from Bombycidae moths: silkworm Bombyx mori and Oberthueria caeca. The degree of coding sequence similarity of the studied elements, their discontinuous distribution, and results of divergence-versus-age analysis make it highly unlikely that these sequences diverged at the same time as their host taxa. The only reasonable alternative explanation is horizontal transfer. In addition, phylogenetic markers for population analysis of Maculinea could be developed based on the described non-LTR retrotransposons.
Russian sheep breeds represent an important economic asset by providing meat and wool, whilst being adapted to extreme climates.

By resequencing two Russian breeds from Siberia: Tuva ( n = 20) and Baikal ( n = 20); and comparing them with a European (UK) sheep outgroup ( n = 14), 41 million variants were called, and signatures of selection were identified. High‐frequency missense mutations on top of selection peaks were found in genes related to immunity ( LOC101109746 ) in the Baikal breed and wool traits ( IDUA ), cell differentiation ( GLIS1 ) and fat deposition ( AADACL3 ) in the Tuva breed. In addition, genes found under selection owing to haplotype frequency changes were related to wool traits ( DSC2 ), parasite resistance ( CLCA1 ), insulin receptor pathway ( SOCS6 ) and DNA repair ( DDB2 ) in the Baikal breed, and vision ( GPR179 ) in the Tuva breed.

Our results present candidate genes and SNPs for future selection programmes, which are necessary to maintain and increase socioeconomic gain from Siberian breeds.
Microinclusions in cuboid diamonds represent the mantle-derived fluid or melt from which they crystallized. The low degree of N aggregation in diamonds with microinclusions (cuboid or coated diamonds) indicates a short mantle residence and suggests that they crystallized shortly before kimberlite eruption. New data on the composition of microinclusions in cuboid diamonds from V. Grib kimberlite pipe (Arkhangelsk province, NW Russia) reveal two contrasting types: carbonatitic and hydrous-silicic. Significant variations in phase relations and in the ratios between different phases in the microinclusions of different diamonds are consistent with the potentially wider compositional variations expected for local volumes of diamond-forming fluids/melts. Compared to the host kimberlites, diamond microinclusions show a strong enrichment in K, a shallower REE profile, and pronounced depletion in Ti, Zr and Y. All microinclusions in diamonds from the V. Grib kimberlite pipe show enrichment in many incompatible elements, which supports their formation by partial melting of metasomatized mantle peridotites and eclogites. These data suggest that the diamonds have crystallized from carbonate-silicate fluids/melts that were derived from a source also common to kimberlites.
The propagation of a detonation wave in a channel with linear expansion in a two-fractional suspension of aluminum particles in oxygen was investigated. Fractions of particles with diameters 3.5 µm and 1 µm were considered. The verified semi-empirical detonation model was used taking into account transition from diffusion to kinetic regime of combustion of micro-sized aluminum particles. The influence of the fractional composition of the mixture on propagation regimes and formation of transverse waves of cellular detonation is established.
The Belle II experiment at KEK in Japan has started real data taking from April 2018 to probe a New Physics beyond the Standard Model by measuring CP violation precisely and rare weak decays of heavy quark and lepton. The experiment is performed at the high luminosity SuperKEKB e^+ e^- collider with 80 x 10^34 cm^-2 s^-1 as an ultimate instantaneous luminosity. In order to develop and test an appropriate trigger algorithm under much higher luminosity and beam background environment than previous KEKB collider, a detail simulation study of the Belle II calorimeter trigger system is very crucial to operate Belle II Trigger and DAQ system in stable. We report preliminary results on various trigger logics and their efficiencies using physics and beam background Monte Carlo events with a Belle II Geant4-based analysis framework called Basf2.
Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control.

Here, we identify the NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway for the G1/S transition. In response to mitogenic stimulation, NUCKS1, a transcription factor, is recruited to chromatin to activate expression of SKP2 , the F-box component of the SCF SKP2 ubiquitin ligase, leading to degradation of p21 and p27 and promoting progression into S phase. In contrast, DNA damage induces p53-dependent transcriptional repression of NUCKS1 , leading to SKP2 downregulation, p21/p27 upregulation, and cell cycle arrest.

We propose that the NUCKS1-SKP2-p21/p27 axis integrates mitogenic and DNA damage signalling to control S phase entry. TCGA data reveal that this mechanism is hijacked in many cancers, potentially allowing cancer cells to sustain uncontrolled proliferation.
We analyse correspondence of a text to a simple probabilistic model. The model assumes that the words are selected independently from an infinite dictionary. The probability distribution correspond to the Zipf---Mandelbrot law. We count sequentially the numbers of different words in the text and get the process of the numbers of different words. Then we estimate Zipf---Mandelbrot law parameters using the same sequence and construct an estimate of the expectation of the number of different words in the text. Then we subtract the corresponding values of the estimate from the sequence and normalize along the coordinate axes, obtaining a random process on a segment from 0 to 1. We prove that this process (the empirical text bridge) converges weakly in the uniform metric on $C (0,1)$ to a centered Gaussian process with continuous a.s. paths. We develop and implement an algorithm for approximate calculation of eigenvalues of the covariance function of the limit Gaussian process, and then an algorithm for calculating the probability distribution of the integral of the square of this process. We use the algorithm to analyze uniformity of texts in English, French, Russian and Chinese.
We demonstrate that first-order light shifts can be canceled for an all-optical, three-photon-absorption resonance (N-resonance) on the D1 transition of 87Rb.

For example, by using a tabletop apparatus designed for N-resonance spectroscopy, we measured a short-term fractional frequency stability (Allan deviation) of approximately/= 1.5 x 10(-11) tao1/2 for observation times of 1 s < or = tao < or = 50 s.

This light-shift cancellation facilitates improved frequency stability for an N-resonance clock. Further improvements in frequency stability should be possible with an apparatus designed as a dedicated N-resonance clock.
In the present paper we numerically study instrumental impact on statistical properties of quasi-CW Raman fiber laser using a simple model of multimode laser radiation. Effects, that have the most influence, are limited electrical bandwidth of measurement equipment and noise. To check this influence, we developed a simple model of the multimode quasi- CW generation with exponential statistics (i.e. uncorrelated modes). We found that the area near zero intensity in probability density function (PDF) is strongly affected by both factors, for example both lead to formation of a negative wing of intensity distribution. But far wing slope of PDF is not affected by noise and, for moderate mismatch between optical and electrical bandwidth, is only slightly affected by bandwidth limitation. The generation spectrum often becomes broader at higher power in experiments, so the spectral/electrical bandwidth mismatch factor increases over the power that can lead to artificial dependence of the PDF slope over the power. It was also found that both effects influence the ACF background level: noise impact decreases it, while limited bandwidth leads to its increase.
From 1770 to 1955, the genesis question was frequently limited to discussions based on observations on host rock and agate thick sections.

Over the next 25 years, experimental investigations examined phase transformations when silica glass and various forms of amorphous silica were heated to high temperatures. This work demonstrated that the change from the amorphous state into chalcedony was likely to be a multi-stage process. The last 40 years has seen modern scientific instrumentation play a key role in identifying the physical and chemical properties of agate.

The outcome of this work has allowed limited evidence-based comment on the conditions of agate formation. There is a general consensus that agates in these basic igneous hosts form at <100 °C. However, the silica source and the nature of the initial deposit remain to be proven.
Depolymerisation of the MT cytoskeleton during late prophase makes it impossible to follow the cytoskeleton cycle in centrosomeless plant meiocytes. This paper describes rearrangements of the MT cytoskeleton during plant meiotic spindle formation in normally dividing pollen mother cells in various higher plant species and forms in which the cytoskeleton does not depolymerise at prophase. In such variants of the wild-type, cytoskeleton rearrangements can be observed at late prophase/early prometaphase. Radial MT bundles coalesce in the meridian plane, reorientate tangentially, curve and give rise to a developed ring-shaped perinuclear cytoskeleton system at the meridian. During nuclear envelope breakdown this ring disintegrates and splits into a set of free MT bundles. Three sub-stages of prometaphase are indicated: early prometaphase (disintegration of perinuclear ring and invasion of MTs into the former nuclear area), middle prometaphase or chaotic stage (formation of bipolar spindle fibres), and late prometaphase (formation of bipolar spindle). Analysis of a range of abnormal phenotypes (disintegrated, multiple, polyarchal, chaotic spindles) reveals two previously unknown processes during late prometaphase: axial orientation and consolidation of the spindle fibres.
ПРАВИТЕЛЬСТВО РОССИЙСКОЙ ФЕДЕРАЦИИот 22 декабря 2018 г. № 2914-р МОСКВА 1. Утвердить прилагаемую Стратегию развития минеральносырьевой базы Российской Федерации до 2035 года.2. Минприроды России с участием заинтересованных федеральных органов исполнительной власти разработать и утвердить в 3-месячный срок со дня вступления в силу настоящего распоряжения план мероприятий по реализации Стратегии развития минерально-сырьевой базы Российской Федерации до 2035 года
The article attempts to consider emotional perception and normative orientation in reading with an emphasis on such emotions as shame. Reading is a significant part of the daily lives of researchers, and obviously there are a number of social norms around and about reading.

In the course of the research, an assumption was made that the normative expectations relevant to the reader are able to create a ground for experiencing shame. Phenomenological analysis of interviews and focus group materials with researchers allowed us to identify reasons for shame about professional and leisure reading in relation to regulatory constraints, some explanations of this experience, as well as related features of motivation to read.

The experience of shame in relation to reading comes from the perception of the researcher himself in the modification of reading and the corresponding normative expectations – so, the manifestation of shame was recorded in discussions about both work and leisure reading. It turned out that reading both scientific and leisure literature is perceived by researchers as their status duty, in this regard, its 'inadequacy' becomes a key reason for experiencing shame.
A method for trace element concentration in the microwave accelerated reaction system MARS 5 is developed.

The vapor-phase distillation was used to remove high-purity germanium dioxide matrix as volatile germanium tetrachloride (GeCl 4 ). We specified operating conditions of the microwave system and chose a halogenating agent and its volume. The method of quantitative chemical analysis of germanium dioxide by direct current arc atomic emission spectrometry (DCA AES) was developed. The unit for analysis is equipped with a multichannel spectrum analyzer MAÉS produced by «VMK-Optoélektronika». We also determined the residual content of germanium in the resulting solutions after vapor-phase distillation.

The limits for detection of 46 trace elements in DCA AES analysis of germanium dioxide with preconcentration of trace elements ranged from 0.5 ng/g to 1 μg/g. We carried out validation of the combined procedure using «spike test».
Purpose. We show the main directions of work of the West Siberian archaeological detachment (team) of the Institute of Archaeology and Ethnography SB RAS, demonstrate the methods used and present the results and the possibilities of their interpretation. Results. In 2018, the West Siberian archaeological detachment celebrates the 45th anniversary of its formation. The long-term head of the team is academician V. I. Molodin. All studies are carried out within the framework of a multidisciplinary approach starting from the search for archaeological objects (sites Tartas-1, Vengerovo-2, -2A, -6, Staryi Tartas-5, Ust’-Tartas-1,-2; Chicha-1, Vengerovo-6 and others) to their laboratory investigation. We widely apply a range of analytical methods in all of our activities including almost all stages of research: from the search for archaeological sites to their processing in close cooperation with various scientists. We collaborate with specialists from the Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russia; the Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia; the Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russia; the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; the Institute of Nuclear Physics SB RAS, Novosibirsk, Russia; Novosibirsk National Research State University, Novosibirsk, Russia; the Center of Collective Use (CCU) “Geochronology of Cenozoic”, Novosibirsk, Russia; Heidelberg University, Heidelberg, Germany; Ludwig-Maximilian Munich Institute, Munich, Germany; the Center of Archaeology of Kurt Engelhorn, Mannheim, Germany and others. Conсlusion. Studies of the West Siberian archaeological detachment, which were carried out over the recent two decades, have provided new data that develop existing points of view, clarify existing concepts or allow to build new concepts of historical and cultural processes. It is obvious that the modern paradigm of science requires participation of specialists in natural sciences at all stages of archaeological research.
This paper presents the brief geological and mineralogical characteristics of the Dorozhnoye mesothermal gold ore deposit (Magadan Region, Russia). The gold and silver minerals are represented by electrum (530‰ - 700‰), freibergite, stephanite, pyrargyrite and Bi-diaphorite. The homogeneous fluid inclusions enable one to determine that the quartz-molybdenite veins were formed at a temperature of 340°C to 140°C, and that the quartz-sulfide gold ore veins were formed at a temperature of 165°C to 125°C. It is assumed that the fluid had a mixed composition and evolved from K-chloride and K-carbonate to Na-chloride. The hypergenesis zone contains: high fineness gold (800‰ - 950‰), petrovskaite (AgAuS) and uytenbogaardtite (Ag3AuS2) associated with goethite and melanterite. The surface waters contain: Ca++ up to 293 mg/L, HCO3 up to 125 mg/L, SO4 up to 777 mg/L; рН is 5.8 to 7.2. Thermodynamic calculations have been conducted and Eh-pH diagrams have been built for the Au-Ag-S-H2O system at 25°C and 100°C (p = 1 bar) to reveal gold and silver stability fields. Au-Ag sulfides at the Dorozhnoye deposit are formed under oxidizing conditions and an acidic environment with dominating sulfates.
We consider two-machine routing open shop problem on a tree. In this problem a transportation network with a tree-like structure is given, and each node contains some jobs to be processed by two mobile machines. Machines are initially located in the predefined node called the depot, have to traverse the network to perform their operations on each job (and each job has to be processed by both machines in arbitrary order), and machines have to return to the depot after performing all the operations. The goal is to construct a feasible schedule for machines to process all the jobs and to return to the depot in shortest time possible. This problem is known to be NP-hard even in the case when the transportation network consists of just two nodes. We propose an instance reduction procedure which allows to transform any instance of the problem to a simplified instance on a chain with limited number of jobs. The reduction considered preserves the standard lower bound on the optimum. We describe four possible outcomes of this procedure and prove that in three of them the initial instance can be solved to the optimum in linear time, thus introducing a wide polynomially solvable subclass of the problem considered. Our research can be used as a foundation to construct efficient approximation algorithms for the two-machine routing open shop on a tree.
During recent years, the BODIPY core became a popular scaffold for designing photoremovable protecting groups (PPG). In this paper, we report the synthesis of a new molecule—8-[4-(2-hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene—by the treatment of meso-(4-CO2Me-phenyl)-BODIPY with excess of MeMgI. The product was characterized by 1H, 13C NMR and HRMS. The combination of BODIPY core with tertiary benzilyc alcohol might be promising for utilizing this molecule as visible light removable PPG.
The article examines the topos of HOME and following motifs A. P. Chekhov's late prose.

The 1st story, A Woman's Kingdom, portrays a rich young woman who is bored with her eventless everyday life. Being clever and open-hearted, Anna Akimovna searches for human values, such as empathetic communication, loving family, etc. The fictive time is Christmas Eve and Christmas Day, so genre tradition of Christmas narratives involves miracles connected with status changes. Ritual temporality suggests some fate changes, and it makes Anna Akimovna dream about her matrimony matters with the worker Pimenov. At last she realizes that Pimenov is below her socially, and social instinct leads her closer to vapid and stupid such as Lysevich or important administrative official Krylin. Dull days she spends at home compel her to leave her dreams for humility. Thus, home-associated motifs in the story are boredom, weariness, and humility. The second narrative, At Home, is based on a return plot. Vera Kardina, who has received her education courses in Moscow, suffers from primitive customs of her home estate. Eventually, she realizes that she is becoming as rude and narrow-minded as the others inhabitants. Therefore, she decides to escape into an unhappy marriage. Corresponding motifs are the same: boredom and weariness, but the main character's escape reveals the higher degree of disagreement with her current lifestyle. In the third short story, A Doctor's Visit, the female character's disease is explained by her inner anxiety related to her social role. Liza Lyalikova is the heir of a huge factory, but she worries that it makes her unhappy and lonely. Doctor Korolev is sure that the best way for Liza's recovery is to quit the business. When the characters meet next morning, doctor believes that Liza would leave home. Both characters compare the factory with the devil, the absolute evil force, that forms the main motif of the short story. Here, the HOME topos is reconstructed in symbolic way.

We conclude that the topos of home in Chekhov's late works produces destructive emotions. Main characters of narratives don't feel safe and calm in their homes. Motif dynamics show the development of characters' positions from humility to deliverance.
Non-enzymatic protein glycation is a source of metabolic stress that contributes to cytotoxicity and tissue damage. Hyperglycemia has been linked to elevation of advanced glycation endproducts, which mediate much of the vascular pathology leading to diabetic complications. Enhanced glycation of immunoglobulins and their accelerated vascular clearance is proposed as a natural mechanism to intercept alternative advanced glycation endproducts, thereby mitigating microvascular disease. We reported that antibodies against the glycoprotein KLH have elevated reactivity for glycopeptides from diabetic serum. These reactions are mediated by covalent binding between antibody light chains and carbonyl groups of glycated peptides. Diabetic animals that were immunized to induce reactive antibodies had attenuated diabetic nephropathy, which correlated with reduced levels of circulating and kidney-bound glycation products. Molecular analysis of antibody glycation revealed the preferential modification of light chains bearing germline-encoded lambda V regions. We previously noted that antibody fragments carrying V regions in the germline configuration are selected from a human Fv library by covalent binding to a reactive organophosphorus ester. These Fv fragments were specifically modified at light chain V region residues, which map to the combining site at the interface between light and heavy chains. These findings suggest that covalent binding is an innate property of antibodies, which may be encoded in the genome for specific physiological purposes. This hypothesis is discussed in context with current knowledge of the natural antibodies that recognize altered self molecules and the catalytic autoantibodies found in autoimmune disease.