Hengzongshu/ArticleAgent huggingface dataset:
The results of experiments and numerical simulation of compression of an intense electron beam in increasing field of magnetic mirror and its transmission through a linear magnetic system are presented. This system is used as a test module for a section of the GOL-3 magnetic trap. The study was carried out for the beam with a spread in initial electron pitch angles and a non-uniform radial current distribution. An analytical estimate of the vacuum beam-current limit was obtained taking into account the initial pitch angles of electrons and the beam compression in the magnetic field. The simulation results are compared with the results of experiments; in both cases similar phenomena of beam reflection and diode breakdown are observed.
Separation of hydrocarbon molecules, such as benzene/cyclohexane and o-xylene/m-xylene/p-xylene, is relevant due to their widespread application as chemical feedstock but challenging because of their similar boiling points and close molecular sizes. Physisorption separation could offer an energy-efficient solution to this problem, but the design and synthesis of sorbents that exhibit high selectivity for one of the hydrocarbons remain a largely unmet challenge.

Herein, we report a new heterometallic MOF with a unique tortuous shape of channels decorated with aromatic sorption sites [Li2Zn2(bpy)(ndc)3] (NIIC-30(Ph), bpy = 4,4′-bipyridine, ndc2– = naphthalene-1,4-dicarboxylate) and study of its benzene/cyclohexane and xylene vapor and liquid separation. Insights into the performance of NIIC-30(Ph) are gained from X-ray structural studies of each aromatic guest inclusion compound.

For an equimolar benzene/cyclohexane mixture, it is possible to achieve a 10-fold excess of benzene in the adsorbed phase. In the case of xylenes, microporous framework NIIC-30(Ph) demonstrates outstanding selective sorption properties and becomes a new benchmark for m-/o-xylene separation. In addition, NIIC-30(Ph) is stable enough to carry out at least three separation cycles of benzene/cyclohexane mixtures or ternary o-xylene/m-xylene/p-xylene mixtures both in the liquid and in the vapor phase.
Glass tube reactors with Pd, Pt, Rh or Ir nanoparticles dispersed on a thin layer of TiO2, CeO2, SiO2 or Al2O3 provided mechanistic insight into the hydrogenation of 1,3-butadiene using parahydrogen.
Septins belong to a family of polymerizing GTP-binding proteins that are important for cytokinesis and other processes that involve spatial organization of the cell cortex.

We reconstituted a recombinant Drosophila septin complex and compared activities of the wild-type and several mutant septin complex variants both in vitro and in vivo. We show that Drosophila septin complex functions depend on the intact GTP-binding and/or hydrolysis domains of Pnut, Sep1, and Sep2. The presence of the functional C-terminal domain of septins is required for the integrity of the complex. Drosophila Orc6 protein, the smallest subunit of the origin recognition complex (ORC), directly binds to septin complex and facilitates septin filament formation. Orc6 forms dimers through the interactions of its N-terminal, TFIIB-like domains.

This ability of the protein suggests a direct bridging role for Orc6 in stimulating septin polymerization in Drosophila. Studies reported here provide a functional dissection of a Drosophila septin complex and highlight the basic conserved and divergent features among metazoan septin complexes.
The essay is concerned with decoding the subject (cognitive) content of R. Kipling's The Spies' March, notable mainly for its proud name. The problem is that the text is created using the double coding technique; it is fundamentally ambiguous and can be read in two ways, allowing in both cases various cognitive and semantic interpretations in the modern historical and cultural context.

The technique of creating and decoding an ambivalent text is, of course, the main object of theoretical analysis. Details of such a false-negative decryption are presented in the section entitled 'Lexical, symbolic and discursive keys for decoding The March'.

Nevertheless, in terms of application, the potential use of the key ideological 'messages' of The March in the global information and political environment, giving now a lot of place to politainment as well as infotainment, is even more important to explore. We consider two major 'messages': 'There are not leaders to lead us to honour' and 'Bring us deliverance, spy!'.
Complex interpretation of seismic and parametric drilling data is performed. The data for interpretation are obtained within the conjunction zone of the Kureyka syncline and the Anabar anteclise. As a result of complex interpretation the structural maps on the bottom of Vendian and the top of the Kuonamka formation are constructed. Map of the Vendian terrigenous complex was constructed. High prospects of oil and gas potential of the lower-middle Cambrian sediments are shown. Based on the analysis of logging data, core description and detailed correlation of time sections, the litho-acoustic models were compiled for two profiles crossing the barrier-reef system, and two-dimensional synthetic time sections were calculated. Obtained results confirm the correctness of the ideas about the internal structure of the Vendian-Cambrian complexes.
The physical and mathematical models for the description of the detonation process in mixtures of hydrogen-oxygen, methane-oxygen and silane-air in the presence of inert nanoparticles were proposed. On the basis of these models the dependencies of detonation velocity deficit vs the size and concentration of inert nanoparticles were found. Three regimes of detonation flows in gas suspensions of reactive gases and inert nanoparticles were revealed: - stationary propagation of weak detonation wave in the gas suspension, - galloping propagation of detonation; - destruction of the detonation process. It was determined that the mechanisms of detonation suppression by micro- and nanoparticles are closed and lies in the splitting of a detonation wave to frozen shock wave and ignition and combustion wave. Concentration limits of detonation were calculated. It turned out that in the transition from microparticles to nanoparticles the detonation suppression efficiency does not increase.
The present paper concerns the problems and main features of the development of ontology for subject-based intelligent scientific Internet resources. In these resources the ontology is used not only for formalization and systematization of the heterogeneous knowledge, data and information processing facilities, but also for organization of a convenient access to them.

Development of ontology providing the above-mentioned functions is a very difficult and laborious process. To facilitate it the methodology including a set of techniques and ontology design patterns, as well as ontology building method using a representative set of base ontologies, is suggested.
A continuous point-like laser discharge of record high temperature has been produced in argon at atmospheric pressure with focusing of the radiation of the Novosibirsk terahertz free electron laser (NovoFEL). According to spectral measurements, the temperature in the center of the millimeter-sized plasma sphere was 28000 K at a plasma density of 1.5×1017 cm-3 and an average NovoFEL power of 200 W at a wavelength of 130 μm (2.3 THz).
In this paper we will present the results of Artin--Markov on braid groups by using the Groebner--Shirshov basis. As a consequence we can reobtain the normal form of Artin--Markov--Ivanovsky as an easy corollary.
Uakitite was observed in small troilite–daubréelite (±schreibersite) inclusions (up to 100 µm) and in large troilite–daubréelite nodules (up to 1 cm) in Fe-Ni-metal (kamacite) of the Uakit iron meteorite (IIAB), Republic of Buryatia, Russia. Such associations in the Uakit meteorite seemed to form due to high-temperature (>1000 °C) separation of Fe-Cr-rich sulfide liquid from Fe-metal melt. Most inclusions represent alternation of layers of troilite and daubréelite, which may be a result of solid decay of an initial Fe-Cr-sulfide.

These inclusions are partially resorbed and mainly located in fissures of the meteorite, which is now filled with magnetite, and rarely other secondary minerals. Structural data were obtained for three uakitite crystals using the electron backscatter diffraction (EBSD) technique. Fitting of the EBSD patterns for a synthetic VN model (cubic, Fm-3m, a = 4.1328(3) Å; V = 70.588(9) Å3; Z = 4) resulted in the parameter MAD = 0.14–0.37° (best-good fit). Analytical data for uakitite (n = 54, in wt. %) are: V, 71.33; Cr, 5.58; Fe, 1.56; N, 21.41; Ti, below detection limit (<0.005).

Phase relations indicate that uakitite is one of the early minerals in these associations. It forms isometric (cubic) crystals (in daubréelite) or rounded grains (in schreibersite). The size of uakitite grains is usually less than 5 μm. It is associated with sulfides (daubréelite, troilite, grokhovskyite), schreibersite and magnetite. Carlsbergite CrN, a more abundant nitride in the Uakit meteorite, was not found in any assemblages with uakitite. Physical and optical properties of uakitite are quite similar to synthetic VN: yellow and transparent phase with metallic luster; Mohs hardness: 9–10; light gray color with a pinky tint in reflected light; density (calc.) = 6.128 g/cm3. Uakitite is structurally related to the osbornite group minerals: carlsbergite CrN and osbornite TiN. The empirical formula (V0.91Cr0.07Fe0.02)1.00N1.00 indicates that chromium incorporates in the structure according to the scheme V3+ → Cr3+ (up to 7 mol. % of the carlsbergite end-member).
An experimental study aimed at the modeling of dolomite- and ankerite-involving decarbonation reactions, resulting in the CO2 fluid release and crystallization of Ca, Mg, Fe garnets, was carried out at a wide range of pressures and temperatures of the upper mantle.

Experiments were performed using a multi-anvil high-pressure apparatus of a 'split-sphere' type, in CaMg(CO3)2-Al2O3-SiO2 and Ca(Mg,Fe)(CO3)2-Al2O3-SiO2 systems (pressures of 3.0, 6.3 and 7.5 GPa, temperature range of 950–1550 °C, hematite buffered high-pressure cell). It was experimentally shown that decarbonation in the dolomite-bearing system occurred at 1100 ± 20 °C (3.0 GPa), 1320 ± 20 °C (6.3 GPa), and 1450 ± 20 °C (7.5 GPa). As demonstrated by mass spectrometry, the fluid composition was pure CO2. Composition of synthesized garnet was Prp83Grs17, with main Raman spectroscopic modes at 368–369, 559–562, and 912–920 cm−1. Decarbonation reactions in the ankerite-bearing system were realized at 1000 ± 20 °C (3.0 GPa), 1250 ± 20 °C (6.3 GPa), and 1400 ± 20 °C (7.5 GPa). As a result, the garnet of Grs25Alm40Prp35 composition with main Raman peaks at 349–350, 552, and 906–907 cm−1 was crystallized.

It has been experimentally shown that, in the Earth's mantle, dolomite and ankerite enter decarbonation reactions to form Ca, Mg, Fe garnet + CO2 assemblage at temperatures ~175–500 °C lower than CaCO3 does at constant pressures.
Background The cereal family Poaceae is one of the largest and most diverse angiosperm families. The central component of centromere specification and function is the centromere-specific histone H3 (CENH3). Some cereal species (maize, rice) have one copy of the gene encoding this protein, while some (wheat, barley, rye) have two. We applied a homology-based approach to sequenced cereal genomes, in order to finally trace the mutual evolution of the structure of the CENH3 genes and the nearby regions in various tribes. Results We have established that the syntenic group or the CENH3 locus with the CENH3 gene and the boundaries defined by the CDPK2 and bZIP genes first appeared around 50 Mya in a common ancestor of the subfamilies Bambusoideae, Oryzoideae and Pooideae. This locus came to Pooideae with one copy of CENH3 in the most ancient tribes Nardeae and Meliceae. The βCENH3 gene as a part of the locus appeared in the tribes Stipeae and Brachypodieae around 35–40 Mya. The duplication was accompanied by changes in the exon-intron structure. Purifying selection acts mostly on αCENH3s, while βCENH3s form more heterogeneous structures, in which clade-specific amino acid motifs are present. In barley species, the βCENH3 gene assumed an inverted orientation relative to αCENH3 and the CDPK2 gene was substituted with LHCB-l . As the evolution and domestication of plant species went on, the locus was growing in size due to an increasing distance between αCENH3 and βCENH3 because of a massive insertion of the main LTR-containing retrotransposon superfamilies, gypsy and copia , without any evolutionary preference on either of them. A comparison of the molecular structure of the locus in the A, B and D subgenomes of the hexaploid wheat T. aestivum showed that invasion by mobile elements and concomitant rearrangements took place in an independent way even in evolutionarily close species. Conclusions The CENH3 duplication in cereals was accompanied by changes in the exon-intron structure of the βCENH3 paralog. The observed general tendency towards the expansion of the CENH3 locus reveals an amazing diversity of ways in which different species implement the scenario described in this paper.
Статья посвящена производству допроса на стадии предварительного следствия с использованием тактических приемов и их комбинаций, в частности с применением психологического реагента как тактического средства, которое нашло широкое применение в правоохранительной деятельности органов США.

В работе раскрываются понятие психологического реагента, приемы и способы его применения
Huntington’s disease (HD) is a severe neurodegenerative disorder caused by a CAG triplet expansion in the first exon of the HTT gene.

Here we report the introduction of an HD mutation into the genome of healthy human embryonic fibroblasts through CRISPR/Cas9-mediated homologous recombination. We verified the specificity of the created HTT-editing system and confirmed the absence of undesirable genomic modifications at off-target sites. We showed that both mutant and control isogenic induced pluripotent stem cells (iPSCs) derived by reprogramming of the fibroblast clones can be differentiated into striatal medium spiny neurons.

We next demonstrated phenotypic abnormalities in the mutant iPSC-derived neural cells, including impaired neural rosette formation and increased sensitivity to growth factor withdrawal. Moreover, using electron microscopic analysis, we detected a series of ultrastructural defects in the mutant neurons, which did not contain huntingtin aggregates, suggesting that these defects appear early in HD development. Thus, our study describes creation of a new isogenic iPSC-based cell system that models HD and recapitulates HD-specific disturbances in the mutant cells, including some ultrastructural features implemented for the first time.
Отраслевые правовые доктрины остро нуждаются в формировании устойчивой конституционно-правовой позиции как метаюридической, ценностной основы, позволяющей сгенерировать императивы отраслевого правотворчества и правореализации.В науке финансового права актуальными являются такие проблемы, как определение предметно-методологической составляющей отрасли, формирование ее системы и др.В поиске решений обозначенных проблем автор статьи предлагает обратиться к исследованию метаюридической сущности финансового права, используя категорию достоинства личности как экзистенциальной ценности, проникающей в национальное право и претендующей на статус принципа права, комплексного межотраслевого института и субъективного права.В этих целях рассмотрено развитие легитимации и легализации данной категории, ее влияние на финансово-правовое регулирование, выделены особенности финансового права и его роль в формировании комплексного межотраслевого института достоинства личности в национальном законодательстве
the classic problem of ship waves generated by a submerged ball that moves rectilinearly with constant velocity parallel to the equilibrium surface of the liquid

a new method for solving the problem of ship waves excited on the surface of a nonviscous liquid by a submerged object that moves at a variable speed

derived asymptotic expressions describing the vertical displacement of the liquid surface in the limit of small and large values of the Froude number; the exact solution is presented in the form of two terms, each reduced to one-dimensional integrals describing the Bernoulli hump and Kelvin wedge; for vertical oscillation case, solution leads to calculation of one-dimensional integral describing surface waves propagating from the epicenter above the ball
An experimental study of the influence of thermo-capillary forces and shear stresses with the side of the gas flow to the evaporation flow rate has been made.

The experiments were carried out at various thicknesses of the liquid layer and constant gas velocity. The influence of the thickness of the liquid layer on the evaporation flow rate (the intensity of evaporation) has been analyzed.

It is shown that the thermocapillary forces have a direct effect on the evaporation flow rate of the liquid layer.
ABSTRACT We explored functional roles of two H3K9-specific histone methyltransferases of Drosophila melanogaster, SetDB1 (also known as Eggless) and Su(var)3-9. Using the DamID approach, we generated the binding profile for SetDB1 in Drosophila salivary gland chromosomes, and matched it to the profile of Su(var)3-9. Unlike Su(var)3-9, SetDB1 turned out to be an euchromatic protein that is absent from repeated DNA compartments, and is largely restricted to transcription start sites (TSSs) and 5′ untranslated regions (5′UTRs) of ubiquitously expressed genes. Significant SetDB1 association is also observed at binding sites for the insulator protein CP190. SetDB1 and H3K9 di- and tri-methylated (me2 and me3)-enriched sites tend to display poor overlap. At the same time, SetDB1 has a clear connection with the distribution of H3K27me3 mark. SetDB1 binds outside the domains possessing this modification, and about half of the borders of H3K27me3 domains are decorated by SetDB1 together with actively transcribed genes. On the basis of poor correlation between the distribution of SetDB1 and H3K9 methylation marks, we speculate that, in somatic cells, SetDB1 may contribute to the methylation of a broader set of chromosomal proteins than just H3K9. In addition, SetDB1 can be expected to play a role in the establishment of chromatin functional domains.
This paper focuses on the stability of open queueing systems under stationary ergodic assumptions. It defines a set of conditions, the monotone separable framework , ensuring that the stability region is given by the following saturation rule: 'saturate' the queues which are fed by the external arrival stream; look at the 'intensity' μ of the departure stream in this saturated system; then stability holds whenever the intensity of the arrival process, say λ satisfies the condition λ < μ , whereas the network is unstable if λ > μ .

The main tool for the proof of this rule is subadditive ergodic theory. This framework involves two main pathwise properties, external monotonicity and separability, which are satisfied by several classical queueing networks.

Whenever the stability condition is satisfied, it is also shown that certain state variables associated with the network admit a finite stationary regime which is constructed pathwise using a Loynes-type backward argument. It is shown that, for various problems, the proposed method provides an alternative to the methods based on Harris recurrence and regeneration; this is particularly true in the Markov case, where we show that the distributional assumptions commonly made on service or arrival times so as to ensure Harris recurrence can in fact be relaxed.
Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances.

Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus

Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.
We present the current status of high-energy cosmic-ray physics and gamma-ray astronomy at the Tunka Astrophysical Center (AC). This complex is located in the Tunka Valley, about 50 km from Lake Baikal.

Present efforts are focused on the construction of the first stage of the gamma-ray observatory TAIGA - the TAIGA prototype. TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) is designed for the study of gamma rays and charged cosmic rays in the energy range 1013 eV–1018 eV. The array includes a network of wide angle timing Cherenkov stations (TAIGA-HiSCORE), each with a FOV = 0.6 sr, plus up to 16 IACTs (FOV - 10∘× 10∘). This part covers an area of 5 km2. Additional muon detectors (TAIGA-Muon), with a total coverage of 2000 m2, are distributed over an area of 1 km2.
We have measured the temperature (2.9 K < T < 50 K) and magnetic field (0 T < B < 9 T) dependences of longitudinal and Hall resistivities for HgCdTe/HgTe/HgCdTe system with HgTe quantum well width of 20.3 nm.

The activation analysis of the experimental magnetoresistivity traces has been used as a quantitative tool to probe inter-Landau level distances.

The activation energies were determined from the temperature dependence of the longitudinal resistivity in the regions of quantized Hall plateaus (for the filling factors ν of 1, 2 and 3) and the indications of the large values of the g factor ≅ 30–75 were found.
7,8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual coding properties. It forms both Watson–Crick (anti)oxoG:(anti)C and Hoogsteen (syn)oxoG:(anti)A base pairs without a significant distortion of a B-DNA helix. DNA polymerases bypass oxoG but the accuracy of nucleotide incorporation opposite the lesion varies depending on the polymerase-specific interactions with the templating oxoG and incoming nucleotides. High-fidelity replicative DNA polymerases read oxoG as a cognate base for A while treating oxoG:C as a mismatch.

In this review, we address the mutagenic potential of oxoG in cells and discuss the structural basis for oxoG bypass by different DNA polymerases and the mechanisms of the recognition of oxoG by DNA glycosylases and dNTP hydrolases.

The mutagenic effects of oxoG in the cell are alleviated by specific systems for DNA repair and nucleotide pool sanitization, preventing mutagenesis from both direct DNA oxidation and oxodGMP incorporation. DNA translesion synthesis could provide an additional protective mechanism against oxoG mutagenesis in cells. Several human DNA polymerases of the X- and Y-families efficiently and accurately incorporate nucleotides opposite oxoG.
The paper considers the possibilities of quality control of the conductive surface and detection of objects on it beyond the horizon, as well as microscopy of flat faces of semiconductor products using surface electromagnetic waves (SEWs) of the terahertz (THz) range.

The conditions under which such methods of control can be implemented are determined; schemes of devices that implement such measurements are elaborated;

estimates of the possibilities of the developed methods for monitoring metal and semiconductor products probed by monochromatic THz radiation in the form of SEWs are given.