Hengzongshu/ArticleAgent huggingface dataset:
A chromodomain is a domain contained in various proteins involved in chromatin remodeling and the regulation of gene expression in eukaryotes during development. Chromodomains perform a wide range of diverse functions including chromatin targeting and interactions between different proteins, RNA and DNA. The chromodomains also have been found as an additional domain at the C-terminal region of Polyproteins (Pol) encoded by transposable elements, which belong to the Gypsy LTR retrotransposons superfamily. Chromoviruses or chromodomain-containing Gypsy LTR retrotransposons form the most widespread clade of Gypsy LTR retrotransposons and can be found in diverse eukaryotes including plants, fungi and vertebrates. The recent finding suggested that chromodomains can be responsible for the targeted integration of LTR retrotransposons and, thus, should be favorable for mobile elements by allowing them to avoid negative selection arising from insertion into coding regions.
This MOF is based on {Zn2(OOCR)4N2} paddle wheels and is isoreticular to the family of [Zn2(bdc)2(dabco)] derivatives (1b; bdc2− = 1,4-benzenedicarboxylate) with pcu topology.

A new metal–organic coordination polymer [Zn2(sedc)2(dabco)] (1se; sedc2− = selepophene-2,5-dicarboxylate; dabco = 1,4-diazabicyclo[2.2.2]octane) was synthesized and characterized by single-crystal X-ray diffraction analysis. The gas adsorption measurements revealed that 1se shows a 15% higher CO2 volumetric uptake at 273 K and 28% higher CO2 uptake at 298 K (both at 1 bar) compared to the prototypic framework 1b. Methane and nitrogen adsorption at 273 K was also investigated, and IAST calculations demonstrated a pronounced increase in CO2/CH4 and CO2/N2 selectivity for 1se, compared with 1b.

The obtained results show a remarkable effect of the presence of selenium atom on the carbon dioxide affinity in the isoreticular metal–organic frameworks with very similar geometry and porosity.
Новосибирский национальный исследовательский государственный университетИнститут экономики и организации промышленного производства СО РАН ПРОБЛЕМЫ ИЗМЕРЕНИЯ ДИВЕРСИФИКАЦИИ РЕГИОНАЛЬНОЙ ЭКОНОМИКИ АннотацияРассмотрены проблемы измерения экономической диверсификации региона.Диверсификация экономики является одним из стратегических приоритетов российских регионов, при этом существующие подходы к измерению и интерпретации оценок многообразны и опираются на различные, порой противоречащие теоретические предположения.Сделан обзор основных индикаторов диверсификации, показаны возможности и ограничения их применения
We would like to thank the staff of participating clinics for their help in collecting biosamples and clinical information. We express our gratitude to the members of the Gene ATLAS project (http://geneatlas.roslin.ed.ac.uk/) and personally thank the Albert Tenesa's group, Oriol Canela-Xandri, and Konrad Rawlik for sharing UK Biobank GWAS summary statistics that we have used in our study. We gratefully thank UK Biobank for establishing a powerful resource for genetic and epidemiological studies.

This work was supported by the Russian Science Foundation [Project No 17-75-20223]. The work of Dr Tsepilov was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Programme.

The authors wish to correct the information in the Acknowledgement section in their paper.
Statistics show negative forecasts of the demographic indicators of the Russian population including their size and health. The human habitat which has been deteriorating in recent decades causes cardinal changes in the assortment and variety of food and significantly contributes to the reduction of their biological value. The depletion of food products (FP) of vegetable and animal origin in vital mineral elements, vitamins and other physiologically active components represents a serious long-term threat to human health and the national security. Industrial methods of enriching FP have certain limitations: a narrow set of micronutrients, their interaction among themselves and accessibility for not all groups of the population. One way to reduce the negative consequences is through the introduction and breeding of new for Russia species and varieties of agricultural plants and organize a mass production of functional foods (FF) that contribute to the prevention and/or suspension of the development of dangerous diseases and slowing down the aging process. The solution of this multifaceted problem lies in changing the consumption structure of foods and their chemical composition conditioned by both the assortment of grown plant species and cultivars of food plants, as well as the composition and quality of soils, fertilizers and the conditions for crop cultivation. Taking into account the prevailing demographic situation in the Russian Federation, it is necessary to create a comprehensive national program for the allocation of new high-content sources of FF ingredients based on traditional and underutilized crops, cultivars and forms of cereal, vegetable and fruit crops and their inclusion in agricultural production as well as existing and newly created technological processes in food industry. The advantages of creating and developing a national system of the functional food in Russia will be: the improvement of public health and life expectancy, the reduction of the Federal Compulsory Medical Insurance Fund expenditures and the development of business structures involved in the production of the FF.
A finite group G is called Schur, if every Schur ring over G is associated in a natural way with a regular subgroup of sym (G) that is isomorphic to G.

We prove that any non-abelian Schur group G is metabelian

and the number of distinct prime divisors of the order of G does not exceed 7.
The reactions of cis-1,2-bis(hydroxylamino)cyclohexane and 2,3-bis(hydroxylamino)-2,3dimethylbutane with polyelectrophilic carbonyl compounds in ethanol were studied.It has been shown that such reactions result in the formation of predominantly five-membered heterocyclic rings with one or two nitrogen atoms.A nitronylnitroxide radical of 2-imidazoline type bearing a 1,3-dicarbonyl function was synthesized.
In this paper, we present the results of thermochemical LIPSS formation on a chromium film with a thickness in the range of 28-350 nm induced by femtosecond laser radiation (λ = 1026 nm, ν = 200 kHz, τ = 232 fs).

The period, height, morphology and chemical composition of TLIPSS as a function of the metal film thickness and focusing configuration are investigated.

The growth of TLIPSS period from 678 nm to 950 nm with increasing thickness of the film has been explained by a formation of oxides with different stoichiometry composition. So, the CrO2 oxide prevails in the composition for the case of TLIPSS formed on thin films which have the minimal period, whereas Cr2O3 oxide is dominant in the case of TLIPSS formed on thick chromium films which have the maximal period value. The results obtained are in agreement with numerical modeling of a period defined by the interference between an incident radiation and a scattered one from a single oxide ridge with a different chemical composition.
Aim.The identification of a protein from human cell extract which specifically interacts with the apurinic/apyrimidinic (AP) site in the partial DNA duplex containing 5'-and 3'-dangling ends (DDE-AP DNA) and mimicking clustered DNA damage.Methods.The Schiff base-dependent cross-linking of a protein to AP DNA (borohydride trapping), MALDI-TOF-MS, chromatography, and gel electrophoresis.Results.A human cell extract protein which forms a major covalent adduct with the AP DNA duplex with dangling ends was identified as the Ku80 subunit of Ku antigen by peptide mass mapping based on MALDI-TOF-MS data.The Ku antigen purified from the HeLa cell extract was shown to form the covalent adducts with the same mobility as observed in cell extracts.Conclusions.The Ku80 subunit of Ku antigen can specifically interact with AP DNA forming the Schiff base-mediated adducts which electrophoretic mobility depends on the structure of DNA ends.The difference in electrophoretic mobility can be caused by the cross-linking of AP DNA to distinct target amino acids that appears to reflect unequal positioning of AP DNAs in the complex with Ku antigen.
The review systematizes modern data on the biochemical markers that can clarify the nature and the course of chronic bronchitis.

The article describes markers associated with bronchopulmonary pathology, such as tumor necrosis factor alpha (TNFα), interleukin 1 (IL-1), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tissue factor, type 1 plasminogen activator inhibitor (PAI-1), and monocyte chemoattractant protein-1 (MCP-1). For each biomolecule, its properties, functions, direct role in body processes, and associations with bronchopulmonary pathology are described.

The use of these markers for early diagnosis of bronchopulmonary pathology and monitoring of the treatment effectiveness is promising and requires further in-depth study.
The region covered is briefly defined and characterized as relatively little disturbed.A survey of relevant odonatological literature, including local Red Lists, is given, along with current scientific activity.Sixteen species are indicated, which deserve special attention, one of them, Ischnura aralensis, being the only strict endemic in the region.Some isolated populations deserving protection are indicated.Regions important for odonate protection are listed, including parts of the Russian Far East in which threatened Chinese populations find a northern refuge.Measures taken for nature protection in the countries considered are also discussed. REGIONAL DEFINITIONThe region's boundaries are determined more by the history of political relationships between two neighbouring empires, the Russian and the Chinese, and their descendants, than by natural biogeographic criteria.In the north and east it is bounded by the Arctic and Pacific Oceans, respectively.Its southern boundary coincides with the border of the former USSR plus the Republic of Mongolia.From east to west, this includes the border between Korea and Russia, the Chinese border with east Russia, the Republic of Mongolia and again Russia, then Kazakhstan, Kyrgyzstan and Tajikistan, then the border of Afghanistan with Tajikistan, Uzbekistan, Turkmenistan and then the border between Turkmenistan and Iran.The western limit of the region, from north to south, roughly and inclusively coincides with the Ural Mountains (55-60°E), the Ural River and the Caspian Sea.Biogeographically it occupies north-eastern Palaearctic.The conventional border of the so-called West and East Palaearctic along the Ural Mountains is justified by convenience only, and the East Palaearctic has been seldom considered as a unit since its Chinese part, until recently, was little known in the West and even less in Russia.This political border has resulted in a discontinuity of our knowledge of
We discuss the process $p+p\to h_1+h_2+X$, where the identified hadrons $h_1$ and $h_2$ have large transverse momenta and are produced in high-energy proton-proton collisions with a large rapidity gap between them. In this case the (calculable) hard part of the reaction receives large higher order corrections $\sim α^n_s\ln^n Δy$, which can be accounted for in the BFKL approach. Specifically, we describe in the next-to-leading order the calculation of the vertex (impact-factor) for the inclusive production of the identified hadron.
This is a continuation of two recent publications of the authors [J. Inverse Ill-Posed Probl., 23 (2015), pp. 415--426; J. Inverse Ill-Posed Probl., 23 (2015), pp. 187--193] about reconstruction procedures for three-dimensional (3-D) phaseless inverse scattering problems. The main novelty of this paper is that, unlike [J. Inverse Ill-Posed Probl., 23 (2015), pp. 187--193], the Born approximation for the case of the wave-like equation is not considered.

It is shown here that the phaseless inverse scattering problem for the 3-D wave-like equation in the frequency domain leads to the well known inverse kinematic problem. Still, since the inverse kinematic problem is very hard to solve, a linearization is applied. More precisely, geodesic lines are replaced with the straight lines. As a result, an approximate explicit reconstruction formula is obtained via the inverse Radon transform. The second reconstruction method is via solving a problem of the integral geometry using integral equations of the Abel type.

The uniqueness theorem follows.
We report an observation of magnetooscillations of the microwave power transmitted through the high mobility two-dimensional electron system hosted by a GaAs quantum well. The oscillations reflect an enhanced absorption of radiation at high harmonics of the cyclotron resonance and follow simultaneously measured microwave-induced resistance oscillations (MIRO) in the dc transport. While the relative amplitude (up to 1%) of the transmittance oscillations appears to be small, they represent a significant (>50%) modulation of the absorption coefficient. The analysis of obtained results demonstrates that the low-B decay, magnitude, and polarization dependence of the transmittance oscillations accurately follow the theory describing photon-assisted scattering between distant disorder-broadened Landau levels. The extracted sample parameters reasonably well describe the concurrently measured MIRO. Our results provide an insight into the MIRO polarization immunity problem and pave the way to probe diverse high-frequency transport properties of high-mobility systems using precise transmission measurements.
The conditions of space flight have a significant effect on the physiological processes in the human body, yet the molecular mechanisms driving physiological changes remain unknown.

Blood samples of 18 Russian cosmonauts who had conducted long-duration missions to the International Space Station were collected 30 days before launch and on the first and seventh days after landing. A panel of 125 proteins in the blood plasma was quantitated by a well-established and highly regarded targeted mass spectrometry approach. This method involves the monitoring of multiple reactions in conjunction with stable isotope-labeled standards at the University of Victoria - Genome BC Proteomics Centre. Reduction of circulating plasma volume during space flight and activation of fluid retention at the final stage of the flight affect the changes in plasma protein concentrations present in the first days after landing. Using an ANOVA approach, it was revealed that only 1 protein (S100A9) reliably responded to space flight conditions.

This protein plays an important role in the functioning of the endothelium and can serve as a marker for activation of inflammatory reactions. Concentrations of the proteins of complement, coagulation cascades, and acute phase reactants increase in the blood of cosmonauts as measured the first day after landing. Most of these proteins' concentrations continue to increase by the 7th day after space flight. Similar dynamics are observed for proteases and their inhibitors. Thus, there is a shift in proteolytic blood systems, which is necessary for the restoration of muscle tissue and maintenance of oncotic homeostasis.
The effects of coherent monochromatic 0.14 THz radiation on human dermal fibroblasts were experimentally investigated using a solid-state radiation source based on an IMPATT diode.

The fibroblast cells were exposed for 20 minutes to a wave beam of different power (10, 30, 50, 70, and 100 mW) and such parameters as proliferative activity, wound closure percentage, and the level of nitric oxide production in irradiated cells were studied.

No tangible changes in the examined parameters were revealed, thereby allowing us to conclude that the low-frequency THz radiation does not affect the functional activity of the human dermal fibroblasts.
Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce.

To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers.

We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.
КОРРЕКЦИЯ КОГНИТИВНЫХ НАРУШЕНИЙ С ИСПОЛЬЗОВАНИЕМ ТРЕНИРУЮЩЕГО ВОЗДЕЙСТВИЯ НА РЕЧЕВЫЕ ДОМЕНЫ МОЗГА
The branching fraction ratio R(D^{*})≡B(B[over ¯]^{0}→D^{*+}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]^{0}→D^{*+}μ^{-}ν[over ¯]_{μ}) is measured using a sample of proton-proton collision data corresponding to 3.0 fb^{-1} of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The semitauonic decay is sensitive to contributions from non-standard-model particles that preferentially couple to the third generation of fermions, in particular, Higgs-like charged scalars.

The tau lepton is identified in the decay mode τ^{-}→μ^{-}ν[over ¯]_{μ}ν_{τ}. A multidimensional fit to kinematic distributions of the candidate B[over ¯]^{0} decays gives R(D^{*})=0.336±0.027(stat)±0.030(syst).

This result, which is the first measurement of this quantity at a hadron collider, is 2.1 standard deviations larger than the value expected from lepton universality in the standard model.
Photoremovable protective groups (PPGs) and related "caged" compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of "caged" compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.
Given an undirected graph with edge weights and a subset R of its edges, the Rural Postman Problem (RPP) is to find a closed walk of minimum total weight containing all edges of R . We prove that RPP is WK[1]‐complete parameterized by the number and weight d of edges traversed additionally to the required ones. Thus RPP instances cannot be polynomial‐time compressed to instances of size polynomial in d unless the polynomial‐time hierarchy collapses.

In contrast, denoting by b ≤ 2 d the number of vertices incident to an odd number of edges of R and by c ≤ d the number of connected components formed by the edges in R , we show how to reduce any RPP instance I to an RPP instance I ′ with 2 b + O ( c / ϵ ) vertices in O ( n 3 ) time so that any α ‐approximate solution for I ′ gives an α (1 + ϵ ) ‐approximate solution for I , for any α ≥ 1 and ϵ > 0 . That is, we provide a polynomial‐size approximate kernelization scheme (PSAKS).

We experimentally evaluate it on wide‐spread benchmark data sets as well as on two real snow plowing instances from Berlin. We also make first steps toward a PSAKS for the parameter c .
Blockchains combine other technologies, such as cryptography, networking, and incentive mechanisms, to enable the creation, validation, and recording of transactions between participating nodes. A consensus algorithm is used in a blockchain system to determine the shared state among distributed nodes. An important component underlying any blockchain-based system is its consensus mechanism, which principally determines the performance and security of the overall system. As the nature of peer-to-peer(P2P) networks is open and dynamic, the security risk within that environment is greatly increased mostly because nodes can join and leave the network at will. Thus, it is important to have a system that can check against malicious behaviour.

In this work, we propose a reputation-based consensus mechanism for blockchain-based systems, Proof-of-Reputation(PoR)

where the nodes with the highest reputation values eventually become part of a consensus group that determines the state of the blockchain.
Chronic heart failure (CHF) and type 2 diabetes mellitus (DM2) and very common comorbidities with bidirectional, mutually aggravating courses. DM2 is known as an independent risk factor of cardiovascular complications whereas a higher CHF functional class is associated with increased risk of DM2. At present time, hypoglycemic drugs of the gliflozin class and the angiotensin receptor-neprilysin inhibitor (ARNI) are widely discussed in connection with their use in the treatment of patients with CHF and DM.

The PARADIGM-HF study investigated effects of long-term treatment of CHF with reduced ejection fraction with presently the only representative of the ARNI class, a single supramolecular complex of valsartan-sacubitril. This medicine has already exceled enalapril at the effect not only on the incidence of nonfatal and fatal cardiovascular events but also on general mortality. Mean age of patients included into that study was 63.8±11.5 years; 21 % of them were females. In real-life clinical practice, physicians more frequently see older patients, and most of them are females, particularly with DM2. On the other hand, sodium-glucose cotransporter-2 inhibitors, including empagliflozin, significantly decreased the death rate and the frequency of CHF exacerbations in patients with DM2 and concomitant cardiovascular diseases, including CHF. This article describes a clinical case of initiating the valsartan-sacubitril treatment in combination with empagliflozin in an elderly female patient with congestive CHF with intermediate ejection fraction (EF) and comorbidities, including a history of myocardial infarction and DM2.

Of interest is the rapid positive dynamics of clinical, laboratory (NT-proBNP) and instrumental (echocardiography) markers of CHF. At 3 months, the EF 'recovered' from intermediate to preserved during the use of a comprehensive cardio-reno-metabolic approach. Both cardiologists and endocrinologists should definitely consider this approach in managing such patients since current cardiological drugs have additional pleiotropic metabolic effects whereas hypoglycemic drugs, in their turn, influence the cardiological prognosis.