Hengzongshu/ArticleAgent huggingface dataset:
The low diversity of the D-subgenome of bread wheat requires the involvement of new alleles for breeding. In grasses, the allelic state of Growth Regulating Factor (GRF) gene is correlated with nitrogen uptake.

In this study, we characterized the sequence of TaGRF-2D and assessed its diversity in bread wheat and goatgrass Aegilops tauschii (genome DD). In silico analysis was performed for reference sequence searching, primer pairs design and sequence assembly. The gene sequence was obtained using Illumina and Sanger sequencing. The complete sequences of TaGRF-2D were obtained for 18 varieties of wheat. The polymorphism in the presence/absence of two GCAGCC repeats in 5' UTR was revealed and the GRF-2D-SSR marker was developed.

Our results showed that the alleles 5' UTR-250 and 5' UTR-238 were present in wheat varieties, 5' UTR-250 was presented in the majority of wheat varieties. In Ae. tauschii ssp. strangulata (likely donor of the D-subgenome of polyploid wheat), most accessions carried the 5' UTR-250 allele, whilst most Ae. tauschii ssp. tauschii have 5' UTR-244. The developed GRF-2D-SSR marker can be used to study the genetic diversity of wheat and Ae. tauschii.
Results of experimental studies of the round hydrogen microjet interaction with a coaxial air for supersonic speed jets efflux are presented in this work.

It is shown that interaction of round and coaxial air jets at their supersonic efflux leads to appearance of a train small/large-scale and, on the contrary, large/small-scale supersonic cells on a resultant jet with growth and reduction of speed of its efflux, respectively. It is found that the result of the round and coaxial air jets interaction at their supersonic efflux does not depend on geometrical parameters of a round and coaxial exit nozzle.
Angular distributions of photons with definite linear polarizations relative to the plane spanned by the momentum of initial electron and the total momentum of the V 1 V 1 pair in the reaction e + e − → V → γ X ( J P ) → γV 1 V 1 ( V = J / ψ , ψ ′,…, Υ(1 S ), Υ,… and V 1 = ρ , ω , ϕ ,…) are calculated. It is shown that the sign of asymmetry of the distributions of photons polarized in the above plane and orthogonal to it correlates with the signature P (−1) J of the X resonance with given spin-parity J P = 0 ± , 1 ± , 2 ± so it may help to establish this quantum number in a way which does not depend on the specific model of the X ( J P ) → V 1 V 1 amplitude.
Mutations in GJB2 gene are a major causes of deafness and their spectrum and prevalence are specific for various populations. The well-known mutation c.35delG is more frequent in populations of Caucasian origin. Data on the c.35delG prevalence in Russia are mainly restricted to the European part of this country. We aimed to estimate the carrier frequency of c.35delG in Western Siberia and thereby update current data on the c.35delG prevalence in Russia. According to a generally accepted hypothesis, c.35delG originated from a common ancestor in the Middle East or the Mediterranean ~ 10,000-14,000 years ago and spread throughout Europe with Neolithic migrations. To test the c.35delG common origin hypothesis, we have reconstructed haplotypes bearing c.35delG and evaluated the approximate age of c.35delG in Siberia.The carrier frequency of c.35delG was estimated in 122 unrelated hearing individuals living in Western Siberia. For reconstruction of haplotypes bearing c.35delG, polymorphic D13S141, D13S175, D13S1853 flanking the GJB2 gene, and intragenic rs3751385 were genotyped in deaf patients homozygous for c.35delG (n = 24) and in unrelated healthy individuals negative for c.35delG (n = 67) living in Siberia.We present updated carrier rates for c.35delG in Russia complemented by new data on c.35delG carrier frequency in Russians living in Western Siberia (4.1%). Two common D13S141-c.35delG-D13S175-D13S1853 haplotypes, 126-c.35delG-105-202 and 124-c.35delG-105-202, were reconstructed in the c.35delG homozygotes from Siberia. Moreover, identical allelic composition of the two most frequent c.35delG haplotypes restricted by D13S141 and D13S175 was established in geographically remote regions: Siberia and Volga-Ural region (Russia) and Belarus (Eastern Europe).Distribution of the c.35delG carrier frequency in Russia is characterized by pronounced ethno-geographic specificity with a downward trend from west to east. Comparative analysis of the c.35delG haplotypes supports a common origin of c.35delG in some regions of Russia (Volga-Ural region and Siberia) and in Eastern Europe (Belarus). A rough estimation of the c.35delG age in Siberia (about 4800 to 8100 years ago) probably reflects the early formation stages of the modern European population (including the European part of the contemporary territory of Russia) since the settlement of Siberia by Russians started only at the end of sixteenth century.
By combining the linear theory and numerical simulations, we study the response of a radially bounded axisymmetric plasma to relativistic charged particle beams in a wide range of plasma densities. We present analytical expressions for the magnetic field generated in the dense plasma, prove vanishing of the wakefield potential beyond the trajectory of the outermost plasma electron, and follow the wakefield potential change as the plasma density decreases. At high plasma densities, wavefronts of electron density and radial electric field are distorted because of beam charge and current neutralization, while wavefronts of wakefield potential and longitudinal electric field are not. At plasma densities lower than or of the order of beam density, multiple electron flows develop in and outside the plasma, resulting in nonzero wakefield potential around the plasma column.
It is known, that the physicochemical properties of materials are defined directly by features of the structure and morphology.Studying of atomic structure and nanostructure of such small objects is an actual problem.X-ray diffraction method can be used for this purpose.Anisotropic broadening of the diffraction peaks, redistribution of the intensities or appearance of diffuse scattering can appear for nanomaterials.Standard X-ray diffraction techniques are often not applicable in this case.

These tasks can be solved by the Debye Function Analysis (DFA) method, based on Debye scattering equation (DSE).It is full-profile method which is applicable for any an arbitrary atoms collection, and therefore can be used for crystalline objects, non-crystalline materials or nanostructures.

Possibilities of modelling diffraction patterns by the DFA by our software [1] will be shown for specific examples of various nanocrystalline materials.It is public-domain software available on the website: www.sourceforge.net/projects/dianna.
The lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory functions of AT, acting as a collector of lipolysis products and adipokines. In its turn, hormones and adipocytokines that produced in adipocytes (including leptin, adiponectin, IL-6, TNF-α, etc.) affect the function of lymphatic endothelial cells and control the growth of lymphatic vessels. Cooperation between LS and AT becomes pathogenetically and clinically important in lymphedema and obesity.

It is known that both primary and secondary lymphedema are characterized by increased fat accumulation which is associated with the severity of lymphostasis and inflammation. Similarly, in obesity, the drainage function of LS is impaired, which is accompanied by perilymphatic mononuclear infiltration in the AT. The development of these changes is facilitated by endocrine dysfunction of adipocytes and impaired production of adipocytokines. The increase in the production of inflammatory mediators and the disruption of the traffic of inflammatory cells causes a further deterioration in the outflow of interstitial fluid and exacerbates the inflammation of the AT, thereby forming a vicious circle.

The role of lymphangiogenesis in AT remodeling in obesity needs further research. Another promising area of research is the study of the role of intestinal LS in the development of obesity and related disorders. It has been shown that the transport of chylomicrons from the intestine depends on the expression of a number of molecular mediators (VEGF-C, DLL-4, neuropilin-1, VEGFR-1, CD36/FAT, etc.)in the endotheliocytes of the intestinal lymphatic vessels, as well as the functioning of «push-button» and “zippering” junctions between endothelial cells. New approach to the treatment of obesity based on blockade of lymphatic chylomicrontransport has been experimentally substantiated. Further identification of the molecular mechanisms and signaling pathways that determine the remodeling of AT in lymphedema and obesity are likely to provide new approaches to the treatment of these diseases.
Objective: to compare the morphological and functional properties of mesenchymal stem cells from mammary tissues and chemically-induced mammary tumor tissues. material and methods. The study included 25 female Wistar rats. In 20 rats, mammary carcinoma was induced by intramammary injection of N-methyl-N-nitrosourea after estrus synchronization with chorionic gonadotropin. The control group consisted of 5 rats. Mammary carcinoma was verified histologically and immunohistochemically. To examine, whether the cells isolated from normal tissue and tumor tissue belonged to mesenchymal stem cells, FACS Canto II flow cytofluorometer was used. The functional properties of mesenchymal stem cells were evaluated in MTT assay by the level of nitric oxide production in normal and by hydrogen peroxide-induced hypoxia. The levels of prolactin, luteinizing hormone and estradiol E2 in urine were studied using solid-phase enzyme-linked immunosorbent assay. results. Chemically-induced mammary tumor according to histological and immunohistochemical studies corresponded to luminal B type breast cancer in humans. In rats that developed mammary tumors, the urine prolactin levels after synchronization of estrus were increased. In rats that did not develop tumors, the levels of prolactin and luteinizing hormone were decreased, but the levels of estradiol E2 were increased. More mesenchymal stem cells with CD45-/CD90+phenotype were obtained from the breast tumor tissue. Mesenchymal stem cells from tumor tissue showed increased proliferative potential and were more resistant to hypoxia. conclusion. Tumor- associated mesenchymal stem cells having high proliferative potential and resistance to hypoxia were obtained from chemically-induced mammary tumor tissue. Morphologic and functional differences in mesenchymal stem cells obtained from mammary breast tissue and tumor tissue require further studies.
Summary As previously established, chronic agonistic interactions lead to the development of depression-like state under social defeat stress in the defeated mice and pathology of aggressive behavior in the winning mice. According to the numerous research data, these psychopathological states are accompanied by tremendous molecular and cellular changes in the brain. The paper aimed to study the influence of 20-day period of agonistic interactions on the expression mode of collagen family genes, encoding the proteins, which are basic components of extracellular matrix (ECM), in the different brain regions of mice using the RNA-Seq database. Most of the differentially expressed collagen genes were upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of the defeated mice. In the ventral tegmental area the most genes were downregulated in both experimental groups. It has been assumed that aberrant expression of collagen genes induced by long experience of agonistic interactions can indicate defects of ECM specific for brain regions in mice with alternative social experiences. This study first shows remodeling of molecular base in the ECM under development of experimental psychoneuropathologies. Corresponding authors: Kudryavtseva N.N., n.n.kudryavtseva@gmail.com ; Babenko V.N., bob@bionet.nsc.ru
It is shown that the efficiency of the universe heating by an inflaton field depends not only on the possible presence of parametric resonance in the production of scalar particles but also strongly depends on the character of the inflaton approach to its mechanical equilibrium point.

An example of the inflaton potential is presented which creates a proper modification of the evolution of the inflaton toward equilibrium and does not destroy the nice features of inflation.

In particular, when the inflaton oscillations deviate from pure harmonic ones toward a succession of step functions, the production probability rises by several orders of magnitude. This in turn leads to a much higher temperature of the universe after the inflaton decay, in comparison to the harmonic case.
Classical knot theory can be generalized to virtual knot theory and spatial graph theory. In 2007, Fleming and Mellor combined virtual knot theory and spatial graph theory to form, combinatorially, virtual spatial graph theory. In this paper, we introduce a topological definition of virtual spatial graphs that is similar to the topological definition of a virtual link. Our main goal is to generalize the classical Yamada polynomial that is defined for a spatial graph. We define a generalized Yamada polynomial for a virtual spatial graph and prove that it can be normalized to a rigid vertex isotopic invariant and to a pliable vertex isotopic invariant for graphs with maximum degree at most 3. We consider the connection and difference between the generalized Yamada polynomial and the Dubrovnik polynomial of a classical link. The generalized Yamada polynomial specializes to a version of the Dubrovnik polynomial for virtual links such that it can be used to detect the non-classicality of some virtual links. We obtain a specialization for the generalized Yamada polynomial (via the Jones-Wenzl projector $P_2$ acting on a virtual spatial graph diagram), that can be used to write a program for calculating it based on Mathematica Code.
In the past three decades, the higher education system of China has shown the most dynamic development. One of the reasons is the president responsibility under the leadership of the Party committee, which was introduced in public universities in the early 1990s and corresponds to the national traditions as the fundamental management system in Chinese general universities. Recent changes in the Chinese society and economy have led to the establishment of private and joint universities, which determined transformations of this management system and the development of several university management systems.

The article is based on the data of the Chinese Ministry of Education, laws and other regulations of the Chinese government in the higher education, websites of the leading Chinese universities, and publications available on the Chinese Internet.

The article aims at describing the features of the contemporary university management systems of different forms of ownership in China together with their advantages and disadvantages. The article provides a brief review of the history of the development of public university management systems from the founding of the PRC to the present day; explains the main features of the Chinese higher education system and the changes in the number of public, private and joint universities in the past ten years. The authors focus on the management systems of public, private and joint universities to show that the management system of the university of any form of ownership consists of three parts - decision-making, practices and control. The article explains the specifics of relations between the highest governing bodies of the university - party committee, president and governing board (board of directors) - and the real system of relations between the administrative and academic authorities.
Роль Конституции в процессе реализации и обеспечения репродуктивных прав человека и гражданина в Российской Федерации
Considering the increasing amount of elderly people in Russia and in the world, an active study of arterial hypertension in this group is an actual and clinically demanded task. The strategic direction defining treatment tactic in such patients, especially over 80 years old, is the determination of their functional status and of the presence of frailty syndrome, which is not synonymous with comorbidity and is not an obligatory early aging companion, but specifies the need for a personalized approach in the treatment of hypertension, even the complete abolition of antihypertensive drugs if needed.

The review presents data on the prevalence and clinical features of hypertension in the older age group and presents a digest of the latest European and Russian clinical guidelines about this topic. Special attention is paid to “fragile” patients from the point of view of evidence-based medicine. The influence of different combinations of antihypertensive drugs on cardiovascular events, mortality and cognitive potential is also explained.

Aim: To evaluate the functional, cognitive and emotional state of long-livers for determining the amount of necessary assistance from social services and medical personnel.
The article is devoted to the development of semi-automated methods for integrating knowledge extracted from natural language texts.

To solve this problem, we use methods for converting natural language sentences into fragments of atomic diagram of algebraic systems. The knowledge extracted from texts is formalized with atomic sentences of signature consisting of constant symbols, binary predicates and additional situation-constants.

We developed methods for integrating knowledge contained in several sentences of natural language, allowing to take their semantic contexts into account.
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation.

This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins.

The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.
Using a new result on the integral involving the product of Bessel functions and associated Laguerre polynomials, published in the mathematical literature some time ago, we present an alternative method for calculating discrete-discrete transition form factors for hydrogen-like atoms. For comparison, an overview is also given of two other commonly used methods.
This paper presents a description of algorithms for solving direct and inverse climatic and environmental problems based on a variational principle with weak constraints. The initial first-order system is supplemented by a system of equations in variations. It provides a calculation of all necessary components of the modeling system by combining the model and observation data and including first- and second-order functionals of sensitivity to variations in the model parameters, input data, and observation results.
введение Нимфомийиды (Nymphomyiidae) -архаичное и плохо изученное семейство высокоспециализированных двукрылых насекомых, представители которого являются филогенетическими и географическими реликтами.эти очень маленькие, длиной 1.5-2.8мм, беспозвоночные животные населяют предгорные и горные реки Азии и Северной Америки.Семейство Nymphomyiidae установлено в 1932 г. известным японским диптерологом М
The main concepts of the theory of tensors are presented. The emphasis is on the basic notions of tensor algebra and practical skills in culculations involving the Kronecker delta and Levi-Civita symbol. Sixty routine exercises are included. This article is intended for junior students of physical, mathematical and geophysical departments of Universities
Parahydrogen-induced polarization (PHIP) is an NMR hyperpolarization technique that increases nuclear spin polarization by orders of magnitude, and it is particularly well-suited to study hydrogenation reactions. However, the use of high-field NMR spectroscopy is not always possible, especially in the context of potential industrial-scale reactor applications. On the other hand, the direct low-field NMR detection of reaction products with enhanced nuclear spin polarization is challenging due to near complete signal cancellation from nascent parahydrogen protons. We show that hydrogenation products prepared by PHIP can be irradiated with weak (on the order of spin-spin couplings of a few hertz) alternating magnetic field (called Spin-Lock Induced Crossing or SLIC) and consequently efficiently detected at low magnetic field (e.g., 0.05 T used here) using examples of several types of organic molecules containing a vinyl moiety. The detected hyperpolarized signals from several reaction products at tens of millimolar concentrations were enhanced by 10000-fold, producing NMR signals an order of magnitude greater than the background signal from protonated solvents.
In analytical form, the peculiarities of forming Fraunhofer diffraction patterns and images of faces of a volumetric asymmetric edge of an object with an absolutely reflective internal surface in relation to dimensional inspection were investigated. Formulas were obtained for calculating fields in diffraction-limited systems depending on the magnitude of the bevel of the object c , the phase shift j of the wave reflected from the inner surface of the object, and the angular aperture of the coherent optical system for forming and filtering images. It has been established that for metal 3D-objects (j = p), the value of the field in the image of the back face at a point, corresponding to the position of its border is negligible with the depth of focus of the system much less than the thickness of the object. It is shown that when bevels of an object, much less than the size of the Fresnel zone d ~ ( l - wavelength of light, d - thickness of the object) and more than the depth of focus, the displacement of the intensity profile in the image of the front face is proportional and depends on the angle j. With large bevels, when and, the displacement of the front face boundary is inversely proportional to the value. These displacements can lead to systematic errors in measuring the position of the boundaries of the faces of a 3D-object and should be taken into account in precision dimensional inspection.