Hengzongshu/ArticleAgent huggingface dataset:
The Tunka-Grande and TAIGA-Muon arrays are the part of a single experimental complex, which also includes the Tunka-133 and TAIGA-HiSCORE (High Sensitivity COsmic Rays and gamma Explorer) wide-angle Cherenkov arrays, TAIGA-IACT array (Imaging Atmospheric Cherenkov Telescope) and Tunka-Rex radio antennas array (Tunka Radio Extension). This complex is located in the Tunka Valley (Buryatia Republic, Russia), 50 km from Lake Baikal.

It is aimed at investigating the energy spectrum and mass composition of charged cosmic rays in the energy range 100 TeV - 1000 PeV, searching for diffuse gamma rays above 100 TeV and studying local sources of gamma rays with energies above 30 TeV. This report outlines 3 key points. The first is a description of the Tunka-Grande and TAIGA-Muon scintillation arrays.

The second part presents preliminary results of the search for diffuse gamma rays with energies above 50 PeV according to the Tunka-Grande data. The third part is devoted to the prospects of the search for diffuse gamma rays with energies above 100 TeV using the TAIGA-Muon array.
Relevance. The spatial dimension of economic development is always in the focus of the political and research agenda. Regional disparities, along with different rates of the spread of the coronavirus pandemic and decentralization of restrictive measures, resulted in significant differences in Russian regions’ economic responses to the pandemic. The relevance of this study is determined by the need to investigate the reasons behind these regional discrepancies.

Research objective. This study aims to analyze the economic consequences of the pandemic-related restrictions and the degree of the spatial heterogeneity of these effects in Russia. Data and methods. We rely on the Rosstat data to build the indicator of the level of economic activity in Russian regions in April-May 2020. We tested the hypothesis that developed regions, large cities and small businesses will suffer more, and considered the impact of the reduced demand in world markets. The significance of the factors was tested by using regression analysis.

Results. The results of our analysis have shown that economic activity in the country decreased by almost 25% due to the lockdown measures, and in some regions, the decline in production output was more than twofold. The urban economy proved to be more resilient to the restrictive measures compared to the average business activity in the country. Due to its diversified structure, the urban system has a wider adaptive capacity and survived the first period of the lockdown with less losses. SMEs, due to their flexibility and entrepreneurial initiative, supported the economies of their regions. Larger and more developed regions, all other things being equal, suffered more from the pandemic. This influence, however, was offset by other factors, and the expected trend towards spatial convergence was not observed. Conclusions. While all the previous crises that Russia experienced in the post-Soviet period were accompanied by decreasing regional discrepancies, during the COVID-19 pandemic, the spatial differences, on the contrary, increased.
This was a long-standing question since 90s whether one-point intersection property for a self-similar set implies open set condition (OSC).

We give an example of a totally disconnected self-similar set which does not have OSC and has minimal overlap of its pieces, that is, all intersections of its pieces are empty except only one, which is a single point.

We answer this question negatively.
The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrate via chemical addition of H2 in the spin-singlet state, but prior to imaging it is typically necessary to transfer the proton polarization to a heteronucleus (usually 13C) in the molecule. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate constant-adiabaticity field cycling and field sweeping for optimal polarization transfer on a model AA$'$X spin system, [1-13C]fumarate. We introduce a method for calculating constant-adiabaticity magnetic field ramps and demonstrate that they enable much faster spin-order conversion as compared to linear ramps used before. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.
Electron paramagnetic resonance spectroscopy, particularly its pulse technique double electron-electron resonance (DEER) (also termed PELDOR), is rapidly becoming an extremely useful tool for the experimental determination of side chain-to-side chain distances between free radicals in molecules fundamental for life, such as polypeptides. Among appropriate probes, the most popular are undoubtedly nitroxide electron spin labels. In this context, suitable biosynthetically derived, helical regions of proteins, along with synthetic peptides with amphiphilic properties and antibacterial activities, are the most extensively investigated compounds.

A strict requirement for a precise distance measurement has been identified in a minimal dynamic flexibility of the two nitroxide-bearing α-amino acid side chains. To this end, in this study, we have experimentally compared in detail the side-chain mobility properties of the two currently most widely utilized residues, namely, Cys(MTSL) and 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC). In particular, two double-labeled, chemically synthesized 20-mer peptide molecules have been adopted as appropriate templates for our investigation on the determination of the model intramolecular separations. These double-Cys(MTSL) and double-TOAC compounds are both analogues of the almost completely rigid backbone peptide ruler which we have envisaged and 3D structurally analyzed as our original, unlabeled compound.

Here, we have clearly found that the TOAC side-chain labels are largely more 3D structurally restricted than the MTSL labels. From this result, we conclude that the TOAC residue offers more precise information than the Cys(MTSL) residue on the side chain-to-side chain distance distribution in synthetically accessible peptide molecules.
The new experiments are analogues of existing EPR experiments such as the primary echo, Carr-Purcell, ESEEM, stimulated echo and Mims ENDOR.

We propose pulse sequences for Reaction Yield Detected Magnetic Resonance (RYDMR), which are based on refocusing the zero-quantum coherences in radical pairs by non-selective microwave pulses and using the population of a radical pair singlet spin state as an observable. All pulse sequences are supported by analytical results and numerical calculations.

The pulse sequences can be used for more efficient and highly detailed characterization of intermediates of chemical reactions and charge carriers in organic semiconductors.
A new analysis of the 20 μs equilibrium folding/unfolding molecular dynamics simulations of the three-stranded antiparallel β-sheet miniprotein (beta3s) in implicit solvent is presented. The conformation space is reduced in dimensionality by introduction of linear combinations of hydrogen bond distances as the collective variables making use of a specially adapted principal component analysis (PCA); i.e., to make structured conformations more pronounced, only the formed bonds are included in determining the principal components.

It is shown that a three-dimensional (3D) subspace gives a meaningful representation of the folding behavior. The first component, to which eight native hydrogen bonds make the major contribution (four in each beta hairpin), is found to play the role of the reaction coordinate for the overall folding process, while the second and third components distinguish the structured conformations. The representative points of the trajectory in the 3D space are grouped into conformational clusters that correspond to locally stable conformations of beta3s identified in earlier work. A simplified kinetic network based on the three components is constructed, and it is complemented by a hydrodynamic analysis. The latter, making use of "passive tracers" in 3D space, indicates that the folding flow is much more complex than suggested by the kinetic network. A 2D representation of streamlines shows there are vortices which correspond to repeated local rearrangement, not only around minima of the free energy surface but also in flat regions between minima. The vortices revealed by the hydrodynamic analysis are apparently not evident in folding pathways generated by transition-path sampling. Making use of the fact that the values of the collective hydrogen bond variables are linearly related to the Cartesian coordinate space, the RMSD between clusters is determined.

Interestingly, the transition rates show an approximate exponential correlation with distance in the hydrogen bond subspace. Comparison with the many published studies shows good agreement with the present analysis for the parts that can be compared, supporting the robust character of our understanding of this "hydrogen atom" of protein folding.
Experiments with the CMD-3 detector at the electron-positron collider VEPP-2000 started in 2010.

CMD-3 is a general purpose detector designed to study e+e− annihilation into hadrons in the center-of-mass (c.m.) energy range from 0.3 up to2 GeV.

The cross section of the process e+e− → K+ K−π+π− has been measured using 23 pb−1 of integrated luminosity collected in the c.m. energy range 1.5 – 2.0 GeV.
Background: Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation.

Objective: objective was to research characteristic of specific sensitization in patients with atopic dermatitis. Methods: There were 108 patients with atopic dermatitis, 1st group – 31 patient (17 boys and 14 girls) 0-3y.o., 2nd group – 30 (13 boys and 17 girls) 4-13 y.o., 3rd group – 47 (16 men and 31 women) 16-63 y.o. In control group, there were 25 patients (4 men, 21 women) 16-64 y.o. with another dermatological diseases such as psoriasis, acne, rosacea and etc., without atopic dermatitis. In patients of all 4 groups evaluated personal, family allergic anamnesis, drug and food allergy, sensitization by measuring common and specific levels of immunoglobulin E.

Results: 10%, 32%, 27% patients of 1st, 2nd, 3rd groups had food allergy. The main allergens were citruses (37% cases), chocolate (27%) and milk (17%). Conclusion: 44-52% patients with atopic dermatitis and 4% patients without atopy had non-specific sensitization, that characterized five-fold increased serum level of IgE and more. 50-60% patients with atopic dermatitis had specific sensitization. 60% infants at the age under 3 y.o. with atopic dermatitis had sensitization for epithelium of homepets, 50% - for milk, 30% - white-egg. Among adults with atopic dermatitis sensitization was the same, as in control group. 35% patients with dermatoses without atopy had specific sensitization.
Aim To analyze frequency and profile of the lipid-lowering therapy (LLT) in patients with dyslipidemia (DLP) and cardiometabolic diseases (CMD) in a population sample aged 55-84 years at the current time (2015-2017).Material and methods Despite guidelines on DLP treatment and the availability of effective and safe lipid-lowering drugs, control of DPL in primary and secondary prevention of cardiovascular diseases (CVD) is insufficient. Knowledge of the level of pharmaceutical correction of DLP in the Russian population is limited; it requires an LLT assessment in various regions and in a wide age range, and a regular monitoring taking into account changing approaches to the correction of DLP. A random population of men and women aged 55-84 years (n=3 896) was evaluated in Novosibirsk in 2015-2017 (project HAPIEE). A joint DLP category was established as low-density lipoprotein cholesterol (LDL-C) ≥3.0 mmol/l, or total cholesterol (TC) ≥5.0 mmol/l, or triglycerides (TG) ≥1.7 mmol/l, or LLT. The combined group of DLP and CMD included ischemic heart disease (IHD), type 2 diabetes mellitus (DM2), and DLP. Regular LLD treatment for the recent 12 months, excluding the dosage of medicines, was assessed using the Anatomic Therapeutic Chemical (ATC) classification. The conditional control of serum lipids was taken as the achievement of LDL-C <3.0 mmol/l, TC <5.0 mmol/l, and TG <1.7 mmol/l.Results In the study sample, the total prevalence of DLP and CMD was 88 % (82.8 % for men and 91.3 % for women, p<0.001). 48.3% of patients in the IHD group, 35.0% in the DM2 group, 29.4% in the DLP group, and 32.8% in the CMD group took LLT. Control of serum lipids was achieved in 18.3% (37.9 % of patients on LLT) of patients with IHD; 9 % (25.6 % of patients on LLT) of patients with DM2; 7.3 % (24.8 % of patients on LLT) of patients with DLP; and 9.0 % (27.6 % of patients on LLTсреди) in the DLP and CMD group. Women with DM2 and DLP more frequently achieved lipid control than men (p<0.001). 98.7 % of study participants took statins as LLT.Conclusion In the sample of urban population aged 55-84 years in 2015-2017, 90 % of patients had DLP or CMD, and at least ¾ of them required blood lipid control. The lipid control was achieved in every fifth IHD patient and in approximately 40% of those who took LLT. For DM2 or DLP patients, the lipid control was achieved in every tenth patient and in approximately 25% of those receiving LLT. Frequency of lipid control in IHD patients was comparable for men and women; in DM2 and DLP, men less frequently achieved the lipid control than women. About 70% of patients in the combined DLP and CMD group and more than 50% of IHD patients did not take LLT, which considerably contributed to the insufficient lipid control in primary and secondary prevention of atherosclerotic CVDs in this population.
We report the first observation of B0→X(3872)(K+π−) and evidence for B+→X(3872)(K0π+). We measure the product of branching fractions for the former to be B(B0→X(3872)(K+π−))×B(X(3872)→J/ψπ+π−)=(7.9±1.3(stat)±0.4(syst))×10−6 and find that B0→X(3872)K∗(892)0 does not dominate the B0→X(3872)K+π− decay mode. We also measure B(B+→X(3872)(K0π+))×B(X(3872)→J/ψπ+π−)=(10.6±3.0(stat)±0.9(syst))×10−6. This study is based on the full data sample of 711 fb−1 (772×106B¯B pairs) collected at the Υ(4S) resonance with the Belle detector at the KEKB collider.Received 27 January 2015DOI:https://doi.org/10.1103/PhysRevD.91.051101© 2015 American Physical Society
Primary cultures of human glioblastoma were obtained from the surgical material of patients K. (female, 61 years, Ds: relapse of glioblastoma) and Zh. (female, 60 years, Ds: relapse of glioblastoma). The effectiveness of a new therapeutic approach aimed at destroying the cancer cell community was evaluated on the primary cell lines of human glioblastoma culture by employing a new strategy of tumor-initiating stem cell synchronization and a domestic strategy of their eradication "3+1". The key elements of the strategy were the following indicator results: (1) evaluation of the presence of tumor-initiating stem cells in a population of cells from analyzed cultures by their ability to internalize double-stranded labeled DNA (TAMRA+ cells); (2) determination of the reference time points of the repair cycle of DNA interstrand cross-links induced by cross-linking cytostatic mitomycin C; (3) evaluation of cell cycle synchronization; (4) determination of the time (day after therapy initiation) when TAMRA+ cells were synchronously present in phase G1/S of the cell cycle, sensitive to the therapy; and (5) establishment of the TAMRA+ (tumor-initiating stem cells) eradication schedule. The cultures were treated with cross-linking cytostatic mitomycin C and a compositional DNA preparation. After the treatments, cell division slows down, and the cultures degrade. The K cell line completely degraded within 30 days of observation. The cell number of the Zh culture fell to nearly one-third of the starting value by day 15 of observation. On day 15, this indicator constituted 1/7.45 for mitomycin C and 1/10.28 for mitomycin C + DNA with reference to the control. The main target of the mitomycin C + DNA regimen was TAMRA+ tumor-initiating stem cells of the glioblastoma cell populations. The action of mitomycin C alone or in the combination with DNA demonstrated effective elimination of TAMRA+ tumor-initiating stem cells and the whole primary cultures of human glioblastomas.
We discuss the heavy quark spin structure of the recently observed `twin' resonances $Z_b(10610)$ and $Z_b(10650)$ assuming that these are mostly of a `molecular' type, i.e. that their internal dynamics is dominated by the coupling to meson pairs $B^* \bar B - B {\bar B}^*$ and $B^* {\bar B}^*$. We find that the state of the $b \bar b$ pair within the $Z_b(10610)$ and $Z_b(10650)$ resonances is a mixture of a spin-triplet and a spin-singlet of equal amplitude and with the phase orthogonal between the two resonances. Such a structure gives rise to specific relations between observable amplitudes that are in agreement with the data obtained recently by Belle. We also briefly discuss possible properties of the isotopically singlet counterparts of the newly found resonances, and also of their $C$ ($G$) parity opposites that likely exist in the same mass range near the open $B$ flavor threshold.
The Ediacaran macrofossil Charnia masoni Ford is perhaps the most iconic member of the Rangeomorpha: a group of seemingly sessile, frondose organisms that dominates late Ediacaran benthic, deep-marine fossil assemblages. Despite C. masoni exhibiting broad palaeogeographical and stratigraphical ranges, there have been few morphological studies that consider the variation observed among populations of specimens derived from multiple global localities.

We present an analysis of C. masoni that evaluates specimens from the UK, Canada and Russia, representing the largest morphological study of this taxon to date.

We describe substantial morphological variation within C. masoni and present a new morphological model for this species that has significant implications both for interpretation of rangeomorph architecture, and potentially for existing taxonomic schemes. Previous reconstructions of Charnia include assumptions regarding the presence of structures seen in other rangeomorphs (e.g. an internal stalk) and of homogeneity in higher order branch morphology; observations that are not borne out by our investigations. We describe variation in the morphology of third and fourth order branches, as well as variation in gross structure near the base of the frond. The diagnosis of Charnia masoni is emended to take account of these new features. These findings highlight the need for large-scale analyses of rangeomorph morphology in order to better understand the biology of this long-enigmatic group.
A new scenario for creation of galactic magnetic fields is proposed which is operative at the cosmological epoch of the galaxy formation, and which relies on unconventional properties of dark matter.

Namely, it requires existence of feeble but long range interaction between the dark matter particles and electrons. In particular, millicharged dark matter particles or mirror particles with the photon kinetic mixing to the usual photon can be considered. We show that in rotating protogalaxies circular electric currents can be generated by the interactions of free electrons with dark matter particles in the halo, while the impact of such interactions on galactic protons is considerably weaker.

The induced currents may be strong enough to create the observed magnetic fields on the galaxy scales with the help of moderate dynamo amplification. In addition, the angular momentum transfer from the rotating gas to dark matter component could change the dark matter profile and formation of cusps at galactic centers would be inhibited. The global motion of the ionized gas could produce sufficiently large magnetic fields also in filaments and galaxy clusters.
Using the original approach that utilizes statistical thermodynamic theory that has been developed in our group

the phase p-T diagram and hydrate phase composition have been calculated for "CO2 + H2 + H2O". Depending on the CO2 content in the gas phase two hydrates types can be formed: CS-I and CS-II.

It has been found that increasing CO2 content in the gas phase drastically reduces hydrate formation pressure and in the same time reduces hydrogen uptake by the hydrate. While pure H2 hydrates have CS-II structure, addition of more than 2 mol.% of CO2 into the gas phase makes CS-I hydrate structure more stable, that displays worse maximum hydrogen content. These results could be helpful for practical use of hydrates for efficient CO2 utilization and H2 transportation.
Tip-clearance cavitation is one of the most aggressive forms of cavitation as it can cause surface erosion of hydraulic machinery elements and, as a result, their fatigue damage and disturb designed operating conditions. At present, the literature lacks for detailed experimental data on the inception and development of this type of cavitation at various flow conditions. In the paper, a tip-leakage cavitation occurring in the clearance between an end face of a 2D hydrofoil (a scaled-down model of guide vanes (GV) of a Francis turbine) and a transparent wall of the test section was studied. The experiments were carried out for different cavitating regimes on the cavitation number and two attack angles of 3° and 9°, with the gap size (tip clearance width) varied in the range from 0.4 to 0.8 mm. In order to determine the cavitation inception conditions and investigate the dynamics of the tip-leakage cavitation, a high-speed visualization was applied. A modified PIV/PTV technique with a diverging laser beam instead of a laser light sheet was used to measure the mean velocity distributions within the gap. It was shown that the cavitation pattern on the suction side of the GV model impacts the dynamics of the leakage flow in the gap but does not affect the sheet cavity formed close to the foil leading edge in the clearance as well as its size and dynamics. When the gap size is increased, the tip-leakage cavitation initiates at higher cavitation numbers or, in other words, conditions for the cavitation occurrence become more favorable.
The paper reviews the effect of nonmonetary factors on inflation dynamics in Russia from 2000 to 2018. The period under review was divided into two intervals with different economic dynamics: 2000–2008 – the period of economic growth in Russia, 2009–2018 – the period of a slower rate of economic growth. Both periods were analyzed for various nonmonetary factors having an impact on inflation, which helped reveal common as well as distinctive features of nonmonetary factors. Some factors, such as the growth rate of agricultural prices had a significant impact on the consumer price inflation dynamics over the whole period under research. Other nonmonetary factors ceased to have an effect on consumer prices making room for others. Thus, the volume of imports turned out to be significant only in the period from 2009 to 2018, which is explained by the geopolitical situation and introduced economic sanctions. The conducted research confirmed a growing role of nonmonetary factors in the inflation processes. This conclusion requires consideration of specific features of nonmonetary causes of inflation on behalf of the Central bank and the fiscal organs in development of concrete steps to reduce inflation. The priority should continue to be given to effective tariff regulation, modernization of industry and promotion of competition.