Hengzongshu/ArticleAgent huggingface dataset:
The problems of heart failure (HF) are becoming increasingly important every year due to the increasing spread of cardiovascular diseases resulting in its development, as well as the impact of metabolic factors, obesity, drugs and endocrine dysfunctions on the myocardium. Isolation of phenotypes with preserved, mid-ranged and reduced ejection fraction in HF allows ranking the evidence base and identifying groups of patients with preferred drug intervention strategies aimed at achieving the six goals of treating HF patients and, above all, reducing mortality. The results of recent studies have significantly expanded the list of tools for management of HF with reduced ejection fraction (EF), presented today, according to John J. V. McMurray, by five pillars: angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers, angiotensin receptor antagonist/neprilysin inhibitor, beta-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2). On the other hand, the exceptional heterogeneity of patients with HF with preserved and mid-range EF and a prevailing opinion on the need for a unified therapy for patients with HF with mid-range and reduced EF, along with the absence of proven prognosis-modifying drugs, require the identifying phenotypic clusters of patients for targeted selection of a treatment strategy. This was the subject of interest in this literature review.
Molecular magnets Cu(hfac)2LR exhibit an unusual type of photoinduced magnetostructural switching in exchange-coupled copper(II)-nitroxide clusters. Such photoswitching from strongly coupled to weakly coupled spin state (SS → WS) was recently found to be ultrafast, thus enhancing the interest in these systems and the scope of their potential applications. However, to date such SS → WS photoswitching was demonstrated only at cryogenic temperatures, being limited by the absence of suitable SS states and short relaxation times at T > 100 K.

In this work we selected model compound Cu(hfac)2Liso-Pr residing in the mixed SS/WS state at room temperature and investigated it using femtosecond optical spectroscopy.

Photoinduced spin dynamics was detected, and an ultrafast SS → WS photoswitching was for the first time demonstrated at room temperature, constituting an important milestone in the development of copper(II)-nitroxide molecular magnets for practical purposes.
We report on Large-eddy simulations (LES) of flow around a short cylinder mounted in a narrow plane channel in a range of Reynolds numbers 1000, 2000, 3750 based on the bulk velocity of the flow and diameter of the cylinder supplemented with Particle image velocimetry (PIV) measurements for the highest considered Re. First two cases appear to be steady, however, for R e =3750 the flow becomes unsteady with the wake dominated by periodic vortex shedding. In front of the cylinder typical horseshoe vortices are identified intensifying the skin friction and heat transfer on the wall, while in the near wake we observe a quasiperiodic low-frequency secondary motion in the form of a pair of counterrotating eddies developing in the transverse direction. The Karman vortex street remains the dominant pattern, but further downstream from the cylinder the transport across the channel is associated with the secondary streamwise vortices, as also previously observed in slot jets. We observe their impact on heat transfer and skin friction on the wall of the channel.
The dataset contains genome-wide association summary statistics computed for heathspan. The UKB sub-population of 300,447 genetically Caucasian, British individuals were analyzed. For more details see [1]. The data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose. If investigators use these data, any and all consequences are entirely their responsibility. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilisation of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. This research has been conducted using the UK Biobank Resource and the use of the data is guided by the principles formulated by the UK Biobank. When using downloaded data, please cite corresponding paper and this repository: Zenin, A., Tsepilov, Y., Sharapov, S., Getmantsev, E., Menshikov, L. I., Fedichev, P. O., & Aulchenko, Y. (2019). Identification of 12 genetic loci associated with human healthspan. Communications Biology, 2(1), 41. http://doi.org/10.1038/s42003-019-0290-0 Aleksandr Zenin, Yakov Tsepilov, Sodbo Sharapov, Evgeny Getmantsev, Leonid Menshikov, Peter Fedichev, & Yurii Aulchenko. (2018). Genome-wide association summary statistics for human healthspan (Version 1) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.1302861 Funding The work was supported by Russian Ministry of Science and Education under 5-100 Excellence Programme. The work was supported by the Federal Agency of Scientific Organizations via the Institute of Cytology and Genetics (project #0324-2018-0017). This research has been conducted using the UK Biobank Resource. The study has been funded by Gero LLC. Column headers: SNPID - SNP rsID chr - chromosome pos - position (GRCh37 build / hg19) EA - effective allele (coded as "1") RA - reference allele (coded as "0") EAF - effective allele frequency beta - effect size of effective allele se - standard error of effect size Z - Z-value of association -log10(p-value) - minus log10(P-value) of association
Modern Japan is resolutely turning towards creating a full-fledged multicultural society. Becoming aware of the depopulation crisis, many municipalities are actively working to attract foreigners. In combination with other measures of the Japanese government, teaching Japanese to foreigners of all levels ensures mutual understanding.

The concept of “Plain Japanese” (PJL) implies the use of a simplified language with limited vocabulary and a set of elementary grammar. “Plain Japanese” was created as a means of providing information to foreigners, firstly for emergency situations, and secondly for everyday life. The scope of application of “Plain Japanese” over the past 25 years has expanded considerably.

The leading role in the study of “Plain Japanese” belongs to the research team of Professor Iori Isao from Hitotsubashi University (Pref. Tokyo). Prof. Iori believes that “Plain Japanese” can perform the following key functions: 1. “Plain Japanese” as a state guarantee of “compensatory education”. Children of foreigners who grew up in Japan should also be able to socialize unhindered. “Plain Japanese” is suitable for this purpose as well as possible. 2. “Plain Japanese” as a language of communication in regional communities. In order for “Plain Japanese” to successfully perform the role of an intermediary language, not only foreigners should speak and study it, but also the Japanese who work with foreigners. 3. “Plain Japanese” as the initial level of the Japanese language across all regions. These are schools and Japanese courses for foreigners. To teach the initial level of the Japanese language in a very short time, it is necessary to considerably cut down the grammatical and lexical minimum compared to, for example, the school course of the Japanese language. At present, digital technologies have been created for translating texts to the European Congregation Campaign, research groups are being conducted, and educational literature is being produced by initiative groups.
Malignant pleural mesothelioma (MPM) is a devastating malignancy with poor prognosis. Reliable biomarkers for MPM diagnosis, monitoring, and prognosis are needed.

We used data mining techniques and transcriptomic analysis so as to assess the differential transcriptional expression of wound-healing-associated genes in MPM. Moreover, we investigated the potential prognostic value as well as the functional enrichments of gene ontologies relative to microRNAs (miRNAs) of the significantly differentially expressed wound-healing-related genes in MPM.

30 wound-healing-related genes were significantly deregulated in MPM, which are potential targets of hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members. Out of those genes, ITGAV gene expression was a prognostic factor of overall survival in MPM. Our results highlight the role of impaired tissue repair in MPM development and should be further validated experimentally.
Amorphous silicon (&alpha;-Si) film present an inexpensive and promising material for optoelectronic and nanophotonic applications. Its basic optical and optoelectronic properties are known to be improved via phase transition from amorphous to polycrystalline phase. Infrared femtosecond laser radiation can be considered as a promising nondestructive and facile way to drive uniform in-depth and lateral crystallization of &alpha;-Si films that are typically opaque in UV-visible spectral range. However, so far only a few studies reported on utilization of near-IR radiation for laser-induced crystallization of &alpha;-Si providing no information regarding optical properties of the resultant polycrystalline Si films. The present work demonstrates efficient and gentle single-pass crystallization of &alpha;-Si films induced by their direct irradiation with near-IR femtosecond laser pulses coming at sub-MHz repetition rate. Comprehensive analysis of morphology and composition of laser-annealed films by atomic-force microscopy, optical, micro-Raman and energy-dispersive X-ray spectroscopy, as well as numerical modeling of optical spectra, confirmed efficient crystallization of &alpha;-Si and high-quality of the obtained films. Moreover, we highlight localized laser-driven crystallization of &alpha;-Si as a promising way for optical information encryption, anti-counterfeiting and fabrication of micro-optical elements.
Purpose: To determine gender differences in trends of social support levels in an open population aged 25-64 years over long-term period - 23 years in Russia / Siberia (Novosibirsk). Methods: Within the framework of the screening in 1994-95 under the WHO MONICA-psychosocial (MOPSY) program (n = 1527, 43% males, mean age 44.85 ± 0.4 years), in 2003-2005 under the international project HAPIEE (n=1650, 34,9% males, mean age 54,25±0,2 years), in 2013-2016 (n=975, 43,8% males, mean age 34,5±0,4 years) and 2016-2017 гг.( n=663, 41,3% years 51,95±0,32 years) within the framework of the budgetary theme No. АААА-А17-117112850280-2, random representative samples of men and women in one of districts in Novosibirsk were examined. Social support is assessed using the Berkman-Syme scale. The index of close contacts (ICC) and social networks (SNI) was assessed. Results: In 1994, a high prevalence of a low level of close contacts was established in an open population of 25-64 years, more pronounced among men compared with women (62% vs 56.8%). In 2003 and 2013, there was a trend towards a decrease in the frequency of the low close contact index to 46-50%, although the ICC levels did not differ by gender. In 2017, on the contrary, women were 14.4% more likely to show a lack of close contacts compared to men, especially in the 45-54 age group, where the low ICC rate exceeded the 1994 level. The prevalence of low SNI in an open population of 25-64 years in 1994 was similar for men and women and was 77%. In 2003-2005, women in older age groups showed a slight increase in the frequency of low SNI levels up to 80.1%. By 2013, a downward trend in the frequency of low SNI among young age groups of both sexes was established, but this trend turned out to be unstable, and after a short period of time the SNI indicators returned to the 1994 levels. Conclusion: In the period 1994-2005, a high level of social isolation among men and women was determined in the open population. By 2017, the clear trend in the increase in the level of social interactions changed to a negative side, especially among women in the 45-54 age group.
The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells.

The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level.

Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction.
The type of film flow whereby the fluid flows in the form of many streamlets is typically called a rivulet flow. Whereas an individual streamlet bounded by two contact lines is called a rivulet. Special attention has been paid to rivulet flows because of their practical value for a variety of devices in power engineering and chemical technology, such as absorbers, distillation columns, evaporators, and heat exchangers for the liquefaction of natural gas. In the present paper the waves in vertical rivulet are investigated analytically. The Kapitza-Shkadov model is used to describe the wavy rivulet flow since it was well proven in the study of nonlinear waves in falling liquid films over a wide range of Reynolds numbers. The equations of the wavy rivulet flow are derived on the basis of the weighed residual method. These equations turn out to be the projections of the Shkadov's model equations on system of basis functions, constructed in special way. Linearizing these equations results in the dispersion relations for plane waves. The stability criterion for rivulet flows is deduced, and the analysis of dispersion relations depending on dimensionless parameters is carried out.
The "Flora of Russia" project on iNaturalist brought together professional scientists and amateur naturalists from all over the country. Over 10,000 people were involved in the data collection.

Within 20 months, the participants accumulated 750,143 photo observations of 6,857 species of the Russian flora.

This constitutes the largest dataset of open spatial data on the country's biodiversity and a leading source of data on the current state of the national flora. About 87% of all project data, i.e. 652,285 observations, are available under free licences (CC0, CC-BY, CC-BY-NC) and can be freely used in scientific, educational and environmental activities.
Бор-нейтронозахватная терапия

Оценка эффективности на гетеротопической модели глиобластомы U87 у иммунодефицитных мышей линии SCID

Результаты оценки эффективности терапии
Crystals on the move: If they are subjected to a strong light stimulus, crystals of the cobalt coordination compound [Co(NH3)5(NO2)]Cl(NO3) undergo sudden jumps and leap over distances 102–105 times their own size to release the strain that accumulates in their interior. The first quantitative kinematic analysis of this phenomenon is reported. The observed effect could be employed for actuation on the macroscopic scale. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Tick-borne encephalitis (TBE) is a viral infectious disease caused by tick-borne encephalitis virus (TBEV). TBEV infection is responsible for a variety of clinical manifestations ranging from mild fever to severe neurological illness. Genetic factors involved in the host response to TBEV that may potentially play a role in the severity of the disease are still poorly understood.

In this study, using whole-exome sequencing, we aimed to identify genetic variants and genes associated with severe forms of TBE as well as biological pathways through which the identified variants may influence the severity of the disease. Whole-exome sequencing data analysis was performed on 22 Russian patients with severe forms of TBE and 17 Russian individuals from the control group. We identified 2407 candidate genes harboring rare, potentially pathogenic variants in exomes of patients with TBE and not containing any rare, potentially pathogenic variants in exomes of individuals from the control group. According to DAVID tool, this set of 2407 genes was enriched with genes involved in extracellular matrix proteoglycans pathway and genes encoding proteins located at the cell periphery. A total of 154 genes/proteins from these functional groups have been shown to be involved in protein-protein interactions (PPIs) with the known candidate genes/proteins extracted from TBEVHostDB database. By ranking these genes according to the number of rare harmful minor alleles, we identified two genes (MSR1 and LMO7), harboring five minor alleles, and three genes (FLNA, PALLD, PKD1) harboring four minor alleles. When considering genes harboring genetic variants associated with severe forms of TBE at the suggestive P-value < 0.01, 46 genes containing harmful variants were identified.

Out of these 46 genes, eight (MAP4, WDFY4, ACTRT2, KLHL25, MAP2K3, MBD1, OR10J1, and OR2T34) were additionally found among genes containing rare pathogenic variants identified in patients with TBE; and five genes (WDFY4, ALK, MAP4, BNIPL, EPPK1) were found to encode proteins that are involved in PPIs with proteins encoded by genes from TBEVHostDB. Three genes out of five (MAP4, EPPK1, ALK) were found to encode proteins located at cell periphery. Whole-exome sequencing followed by systems biology approach enabled to identify eight candidate genes (MAP4, WDFY4, ACTRT2, KLHL25, MAP2K3, MBD1, OR10J1, and OR2T34) that can potentially determine predisposition to severe forms of TBE. Analyses of the genetic risk factors for severe forms of TBE revealed a significant enrichment with genes controlling extracellular matrix proteoglycans pathway as well as genes encoding components of cell periphery.
The influence of microwave radiation (1.2-140 GHz) on resistance of high-mobility two-dimensional electron gas in GaAs quantum wells is studied.

Two series of microwave-induced magnetoresistance oscillations periodic in 1/B were observed under microwave radiation. The periods of oscillations are determined by the microwave frequency and power, correspondingly.

The experimental data is qualitatively explained by photon-assisted transport and Zener tunneling between Landau orbits.
The color of the grain shell of cereals is an important feature that characterizes the pigments and metabolites contained in it. The grain shell is the main barrier between the grain and the environment, so its characteristics are associated with a number of important biological functions: moisture absorption, grain viability, resistance to pre-harvest germination. The presence of pigments in the shell affects various technological properties of the grain. Color characteristics, as well as the appearance of the grain shell are an important indicator of plant diseases. In addition, the color of the grains serves as a classifying feature of plants. Genetic control of the color formation of both grains and other plant organs is exerted by genes encoding enzymes involved in the biosynthesis of pigments, as well as regulatory genes. For a number of pigments, these genes are well understood, but for some pigments, such as melanin, which causes the black color of grains in barley, the molecular mechanisms of biosynthesis are still poorly understood. When studying the mechanisms of genetic control of grain color, breeders and geneticists are constantly faced with the need to assess the color characteristics of their shell. The technical means of addressing this problem include spectrophotometers, spectrometers, hyperspectral cameras. However, these cameras are expensive, especially with high resolution, both spatial and spectral. An alternative is to use digital cameras that allow you to get high-quality images with high spatial and color resolution. In this regard, recently, in the field of plant phenotyping, methods for evaluating the color and texture characteristics of cereals based on the analysis of two-dimensional images obtained by digital cameras have been intensively developed. This mini-review is devoted to the main tasks related to the analysis of color and texture characteristics of cereals, and to methods of their description based on digital images.
We report a universal straightforward strategy for the chemical synthesis of modified oligoribonucleotides containing functional groups of different structures at the 2′ position of ribose.

The on-column synthetic concept is based on the incorporation of two types of commercial nucleotide phosphoramidites containing orthogonal 2′-O-protecting groups, namely 2′-O-thiomorpholine-carbothioate (TC, as 'permanent') and 2′-O-tert-butyl(dimethyl)silyl (tBDMS, as 'temporary'), to RNA during solid-phase synthesis. Subsequently, the support-bound RNA undergoes selective deprotection and follows postsynthetic 2′ functionalization of the naked hydroxyl group. This convenient method to tailor RNA, utilizing the advantages of solid phase approaches, gives an opportunity to introduce site-specifically a wide range of linkers and functional groups.

By this strategy, a series of RNAs containing diverse 2′ functionalities were synthesized and studied with respect to their physicochemical properties.
The current version of the Gene Transcription Regulation Database (GTRD; http://gtrd.biouml.org) contains information about: (i) transcription factor binding sites (TFBSs) and transcription coactivators identified by ChIP-seq experiments for Homo sapiens, Mus musculus, Rattus norvegicus, Danio rerio, Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Schizosaccharomyces pombe and Arabidopsis thaliana; (ii) regions of open chromatin and TFBSs (DNase footprints) identified by DNase-seq; (iii) unmappable regions where TFBSs cannot be identified due to repeats; (iv) potential TFBSs for both human and mouse using position weight matrices from the HOCOMOCO database.

Raw ChIP-seq and DNase-seq data were obtained from ENCODE and SRA, and uniformly processed. ChIP-seq peaks were called using four different methods: MACS, SISSRs, GEM and PICS. Moreover, peaks for the same factor and peak calling method, albeit using different experiment conditions (cell line, treatment, etc.), were merged into clusters. To reduce noise, such clusters for different peak calling methods were merged into meta-clusters; these were considered to be non-redundant TFBS sets. Moreover, extended quality control was applied to all ChIP-seq data.

Web interface to access GTRD was developed using the BioUML platform. It provides browsing and displaying information, advanced search possibilities and an integrated genome browser.