Hengzongshu/ArticleAgent huggingface dataset:
Reproductive potential is the most important conditional indicator reflecting the ability of individuals in a population to reproduce, survive and develop under optimal environmental conditions. As for humans, the concept of reproductive potential can include the level of the individual’s mental and physical state, which allows them to reproduce healthy offspring when they reach social and physical maturity. Female reproductive potential has been investigated in great detail, whereas the male reproductive potential (MRP) has not received the equal amount of attention as yet.

Therefore, here we focused on the human Y chromosome and found candidate single-nucleotide polymorphism (SNP) markers of MRP. With our development named Web-service SNP_TATA_Z-tester, we examined in silico all 35 unannotated SNPs within 70-bp proximal promoters of the three Y-linked genes, CDY2A, SHOX and ZFY, which represent all types of human Y-chromosome genes, namely: unique, pseudo-autosomal, and human X-chromosome gene paralogs, respectively. As a result, we found 11 candidate SNP markers for MRP, which can significantly alter the TATA-binding protein (TBP) binding affinity for promoters of these genes. First of all, we selectively verified in vitro the values of the TBP-promoter affinity under this study, Pearson’s linear correlation between predicted and measured values of which were r = 0.94 (significance p < 0.005).

Next, as a discussion, using keyword search tools of the PubMed database, we found clinically proven physiological markers of human pathologies, which correspond to a change in the expression of the genes carrying the candidate SNP markers predicted here. These were markers for spermatogenesis disorders (ZFY: rs1388535808 and rs996955491), for male maturation arrest (CDY2A: rs200670724) as well as for disproportionate short stature at Madelung deformity (e. g., SHOX: rs1452787381) and even for embryogenesis disorders (e. g., SHOX: rs28378830). This indicates a wide range of MRI indicators, alterations in which should be expected in the case of SNPs in the promoters of the human Y-chromosome genes and which can go far beyond changes in male fertility.
We report the first observation of the three-body ϒ(5S) → ϒ(1, 2S)π 0 π 0 decays. Strong evidence for the Z 0 b (10610) with 4.9σ significance is found in a Dalitz plot analysis of the ϒ(5S) → ϒ(2S)π 0 π 0 decays.

The results are obtained with a 121.4 fb -1 data sample collected with the Belle detector at the ϒ(5S) resonance at the KEKB asymmetric-energy e + e -collider.

First results on the analysis of the three-body* ] ± are also reported.
In 2016, Guidelines on the medical care organization to the patients with hereditary atherogenic lipid disorders in the regions of Russia were published, which described and presented the principles of routing patients with hereditary dyslipidemia and the organization of medical care for them within the current regulatory documents. In December 2018, the Russian Ministry of Health approved clinical guidelines for the diagnosis and treatment of familial hypercholesterolemia.

Thus, persons with a severe hereditary dyslipidemia were able to get free medication with expensive lipid-lowering drugs and receive apheresis. Following the European ones, the Russian guidelines on the management of lipid metabolism disorders were updated: lower target low density lipoprotein cholesterol levels were adopted.

In the Russian population, there is a high prevalence of hypercholesterolemia, including familial monogenic and polygenic types. Therefore, timely detection and routing to a lipid center or an office to a specialist (cardiologist, lipidologist), adequate and modern prescription of lipid-lowering therapy will make an important contribution not only to secondary, but also to primary prevention of atherosclerotic cardiovascular complications.
The electrical response of a two-dimensional electron gas to vibrations of a nanomechanical cantilever containing it is studied. Vibrations of perpendicularly oriented cantilevers are experimentally shown to oppositely change the conductivity near their bases. This indicates the piezoelectric nature of electromechanical coupling. A physical model is developed, which quantitatively explains the experiment. It shows that the main origin of the conductivity change is a rapid change in the mechanical stress on the boundary between suspended and nonsuspended areas, rather than the stress itself.
The quantum interference between the decays of entangled neutral kaons is studied in the process ϕ → K S K L → π + π − π + π − , which exhibits the characteristic Einstein-Podolsky-Rosen correlations that prevent both kaons to decay into π + π − at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and $$ \mathcal{CPT} $$ CPT violation effects, which may be justified in a quantum gravity framework.

The analysed data sample was collected with the KLOE detector at DAΦNE, the Frascati ϕ -factory, and corresponds to an integrated luminosity of about 1.7 fb − 1 , i.e. to about 1 . 7 × 10 9 ϕ → K S K L decays produced. From the fit of the observed ∆ t distribution, being ∆ t the difference of the kaon decay times, the decoherence and $$ \mathcal{CPT} $$ CPT violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses.

The results are consistent with no deviation from quantum mechanics and $$ \mathcal{CPT} $$ CPT symmetry, while for some parameters the precision reaches the interesting level at which — in the most optimistic scenarios — quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models.
The objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals. Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the GINA recommendations. The Control Group included apparently healthy individuals (n = 217). Patients with allergic asthma underwent standard laboratory and instrumental examinations and DNA typing. Results. A statistically significant predominance of AG genotype frequency in the group of patients with allergic asthma, including women, versus the group of healthy individuals, was established. AG rs2227983 genotype of EGFR gene was found to be significantly more common in patients with mild and moderate allergic asthma including women, than in healthy individuals, including women. Conclusion. The association of rs2227983 polymorphism of EGFR gene with allergic asthma has been established. A homozygous GG genotype may play a protective role against the disease.
F(R)-modified gravitational theories

lead to curvature oscillations in astrophysical systems with rising energy density

The frequency and the amplitude of such oscillations could be very high and would lead to noticeable production of energetic cosmic ray particles
In this work we study the stability of horizontal shear flows of an ideal fluid in an open channel. Stability conditions are derived in terms of the theory of generalized hyperbolicity of motion equations. We show that flows with monotonic convex profile are always stable, whereas flows with an inflexion point in the velocity profile might become unstable. To illustrate the criteria we give simple examples for stable and unstable flows. Then we derive a multilayered model that is an approximation of the original model and features a continuous piecewise linear velocity profile. We also formulate sufficient hyperbolicity conditions for the multilayered model.
topological changes that can occur in mathematical three-space via surgery, with black hole formation, the formation of wormholes and new generalizations of these phenomena

We directly connect topological changes that can occur in mathematical three-space via surgery, with black hole formation, the formation of wormholes and new generalizations of these phenomena

This work widens the bridge between topology and natural sciences and creates a new platform for exploring geometrical physics
The paper presents the results of a study of the tissue-specificity of the circadian phase characteristics of biological processes in the mouse liver and kidneys.

We performed a comparative analysis of the translatomes in these two organs based on experimental data on the daily dynamics of the level of translation of mouse genes from the GEO database (GSE67305 and GSE81283) obtained by ribosome profiling. Genes with a pronounced daily dynamics of translation were revealed (3 358 genes in the liver and 2 938 in the kidneys). Further, for each of the 12 time points (ZT0–ZT22), for each tissue (liver, kidneys), groups of genes that were in a phase with an increased level of translation were identified. It was assumed that the gene is in a phase with an increased level of translation if at a given time point its ribosome profiling rate for both replicas exceeded the daily average value for this gene. A statistical analysis of enrichment of Gene Ontology terms in these twelve gene groups in the liver and kidneys was performed.

The greatest number of rhythmic genes in the liver has an increased level of translation at the beginning of the dark phase of the day corresponding to increased animal activity. In the kidneys, the differences in the distribution of the number of genes in the phase of an elevated translation level by the time of day were less pronounced, and the maximum number of such genes was observed from the middle of the light phase of the day to the middle of the dark one. Analyzing the processes, the rhythmicity of which is typical of both liver and kidneys, we have identified the processes, the circadian phase characteristics of which in these tissues coincide and the processes having essentially different temporal phase patterns for these tissues. Processes with strict tissue-specific rhythmic translation have also been identified. The approach used in our work allows us to analyze the organo/tissue-specificity of the phase characteristics of biological processes, and the results emphasize the need to take into account the phase circadian characteristics when comparing the features of the course of biological processes in various organs.
A schematic presentation for the unexpected blue-shifted luminescence of Eu2+ in M5(Si3O9)2 (M = Sr, Ba, Y, Eu, Mn) based on the preferential occupancy at the designated cation sites
The Black-veined White Aporia crataegi (Lepidoptera: Pieridae) is a trans-Palearctic species causing damage to various fruit and berry crops. Wolbachia bacteria are maternally transmitted intracellular symbionts of many arthropods, including numerous Lepidoptera.

Here we analyzed Wolbachia infection in A. crataegi populations. We have studied 376 samples of A. crataegi collected in 10 regions of Russia from the Far East to Kaliningrad. Wolbachia prevalence was very low; only eight Wolbachia-positive specimens of A. crataegi were detected in Yakutia, Republic of Buryatia, Sverdlovsk and Kaliningrad Provinces, and no infection was found in other localities. Two Wolbachia haplotypes, ST-19 and ST-109, from A and B supergroups respectively, were identified using the multilocus sequence typing (MLST) protocol. These haplotypes were also previously reported in different lepidopteran species. Both Wolbachia haplotypes were associated with the same mtDNA haplotype (as inferred from the cytochrome oxidase subunit I gene) of A. crataegi, and ST-19 with two mtDNA haplotypes.

This incongruence of maternally inherited agents indicates independent cases of the bacteria acquisition in A. crataegi history. The above data suggest that Wolbachia can infect Aporia crataegi but cannot establish in the host populations.
We report the first observation of the decays B^{0}→pΛ[over ¯]D^{(*)-}. The data sample of 711 fb^{-1} used in this analysis corresponds to 772×10^{6} BB[over ¯] pairs, collected at the ϒ(4S) resonance by the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. We observe 19.8σ and 10.8σ excesses of events for the two decay modes and measure the branching fractions of B^{0}→pΛ[over ¯]D^{-} and B^{0}→pΛ[over ¯]D^{*-} to be (25.1±2.6±3.5)×10^{-6} and (33.6±6.3±4.4)×10^{-6}, respectively, where the first uncertainties are statistical and the second are systematic. These results are not compatible with the predictions based on the generalized factorization approach. In addition, a threshold enhancement in the dibaryon (pΛ[over ¯]) system is observed, consistent with that observed in similar B decays.
To analyze major epidemiological parameters of multiple myeloma, i.e. registered incidence, prevalence, mortality, and survival in Novosibirsk, megalopolis in Siberian Federal District.

The study covered medical records of 335 patients with newly diagnosed multiple myeloma (MM) treated from January 1, 2006 to December 31, 2016 at the Center of Hematology in Novosibirsk. Median age was 67 years (range 30-89), the trial enrolled 218 (65 %) women and 117 (35 %) men.

Over the last decade the mean registered MM incidence in Novosibirsk increased by 1.6 times, and MM prevalence increased by 4.9 times. These parameters correspond to 2.4 and 13.8 per 100,000 population per year, respectively, with the linear trend of growth which demonstrates not only the increased number of patients with newly diagnosed MM, but the increased longevity of them. MM incidence and prevalence parameters are significantly higher in women than in men, which most probably can be accounted for by specific administrative factors in the Novosibirsk region. Yearly mortality of MM patients decreased from 28.3 % to 8.2 % with a negative linear trend over the entire analyzed period, which is most likely to be associated with availability of new drugs and transplantation procedures. The obtained epidemiological data will enable to plan the provision of timely and effective care for MM patients and to elaborate a system of judicious allocation of costly equipment and drugs.
We consider the exclusive diffractive dissociation of a proton into three jets with large transverse momenta in the double-logarithmic approximation of perturbative QCD. This process is sensitive to the proton unintegrated gluon distribution at small x and to the proton light-cone distribution amplitudes. According to our estimates, an observation of such processes in the early runs at LHC is feasible for jet transverse momenta of the order of 5 GeV.
The single electron track-reconstruction efficiency is calibrated using a sample corresponding to $1.3~\mathrm{fb}^{-1}$of $pp$ collision data recorded with the LHCb detector in 2017. This measurement exploits $B^+\to J/\psi (e^+e^-)K^+$ decays, where one of the electrons is fully reconstructed and paired with the kaon, while the other electron is reconstructed using only the information of the vertex detector. Despite this partial reconstruction, kinematic and geometric constraints allow the $B^+$-meson mass to be reconstructed and the signal to be well separated from backgrounds. This in turn allows the electron reconstruction efficiency to be measured by matching the partial track segment found in the vertex detector to tracks found by LHCb's regular reconstruction algorithms. The agreement between data and simulation is evaluated, and corrections are derived for simulated electrons in bins of kinematics. These correction factors allow LHCb to measure branching fractions involving single electrons with a systematic uncertainty below $1\%$.
Betulin and its esters are the natural compounds with high in vitro cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball-milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared with the initial substances without losing the structural integrity and functionality. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascites carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin ester derivatives against cancer cells.
Root stem cell niche functioning requires the formation and maintenance of the specific "auxin-rich domain" governed by directional auxin transport and local auxin production. Auxin maximum co-localizes with the WOX5 expression domain in the quiescent center that separates mitotically active proximal and distal root meristems. Here we unravel the interconnected processes happening under WOX5 overexpression by combining in vivo experiments and mathematical modeling. We showed that WOX5-induced TAA1-mediated auxin biosynthesis is the cause, whereas auxin accumulation, PIN transporters relocation, and auxin redistribution between proximal and distal root meristems are its subsequent effects that influence the formation of the well-described phenotype with an enlarged root cap. These findings helped us to clarify the role of WOX5, which serves as a local QC-specific regulator that activates biosynthesis of non-cell-autonomous signal auxin to regulate the distal meristem functioning. The mathematical model with WOX5-mediated auxin biosynthesis and auxin-regulated cell growth, division, and detachment reproduces the columella cells dynamics in both wild type and under WOX5 dysregulation.
Charoitite is a unique rock in the alkaline-carbonatite Murun Complex, Eastern Siberia, Russia with an occurrence of many rare minerals. Here we report a comprehensive summary on mineralogy, major and trace element characteristics of the Ca-(K)-(Na) silicate minerals from charoitites, including charoite, tinaksite, tokkoite, pectolite, fedorite, miserite, agrellite, frankamenite, and hydroxyapophyllite-(K). All these minerals belong to Ca-(K)-(Na) silicates. The content of Al, Fe, and Mg in these silicates is insignificant, though the presence of pyroxene, amphibole, and K-feldspar shows that these elements were present in the system. The high and variable concentration of water, CO2 and F in the majority of the minerals indicates a hydrous- and volatile-rich environment of crystallization. The trace element data show that rare Ca-(K)-(Na) silicate minerals of charoitites are characterized by relatively low content (typically < 0.1 wt%) of trace elements such as Nb, Ta, Th, U, Zr and Rb. The majority of trace elements likely acted not as structural components defining mineral structures, but as trace impurities. The REE distribution patterns show that LREE enrichment and HREE depletion are characteristic for most of the Ca-(K)-(Na) silicates in charoitite, whereas tokkoite and coarse-grained tinaksite could show HREE enrichment. The REE patterns are characterized by the absence of any significant Eu anomaly, indicating the absence of Eu2+ and significant plagioclase fractionation. The initial purple/lilac color of charoite related to Mn can be changed to brown or white color, by weathering and oxidation processes that were associated with the loss of K and Na but retained the trace elements including Mn. The fractionation of trace elements between minerals of charoitites is consistent with their typical geochemical properties and the main reason for the mineralogical diversity of charoitites likely was the limited degree of solid solutions in Ca-(K)-(Na) minerals.
In this paper, we studied the sensing performance of metasurfaces comprised by spiral-disk-shaped metallic elements patterned on polypropylene substrates, which exhibited localized surface plasmon resonances in the low-frequency region of the terahertz (THz) spectrum (0.2–0.5 THz). Optimal designs of spiral disks with C-shaped resonators placed near the disks were determined and fabricated. The experimentally measured transmittance spectra of the samples coated with very thin photoresistive layers (d ~ 10−4–10−3 λ) showed good agreement with the simulations. The resonance frequency shift Δf increases with increasing d, while saturating near d = 50 µm. The narrow-band magnetic dark modes excited on symmetrical spiral disks with a 90° C-resonator demonstrated very high figure of merit (FOM) values reaching 1670 (RIU·mm)−1 at 0.3 μm thick analyte. The hybrid high order resonances excited on asymmetrical densely packed spiral disks showed about two times larger FOM values (up to 2950 (RIU·mm)−1) compared to symmetrical distantly spaced spirals that resembled the best FOM results found in the literature for metasurfaces fabricated with a similar technique. The demonstrated high sensing performance of spiral disks is evaluated to be promising for bio-sensing applications in the THz range.
Drosophila melanogaster and our own species share (Homo sapiens) the history of relatively rapid out-of-Africa dispersal. In Eurasia, they had faced a novel adaptive problem of adjustment of their circadian rhythmicity and night sleep episode to seasonal variation in day length and air temperature. Both species usually respond to heat and a short duration of night by reduction of the amount of night sleep and prolongation of "siesta".

To further explore similarities between the two species in the ways of adjustment of their sleep-wake behavior to extreme environmental factors, this study examined the possibility to distinguish four extreme chronotypes among fruit flies and the possibility of the differential response of such chronotypes to light and heat stressors.Circadian rhythms of locomotor activity and sleep-wake pattern were tested in constant darkness, and four strains of fruit flies originating from three wild populations of Africa, Europe, and the USA were selected to represent four distinct chronotypes: "larks" (early morning and evening activity peaks), "owls" (late morning and evening peaks), "swifts" (early morning and late evening peaks), and "woodcocks" (late morning and early evening peaks). The circadian rhythms and sleep efficiency of the selected chronotypes were further tested under such extreme conditions as either long day (LD20:4 at 20°C) or a combination of LD20:4 with hot temperature (29°C).

Despite the identity of such experimental conditions for four chronotypes, their circadian rhythms and sleep timing showed significantly distinct patterns of response to exposure to heat and/or long days. All two-way repeated measures analysis of variances yielded a significant interaction between chronotype and time of the day (P<0.001).An experimental study of heritable chronotypes in the fruit fly can facilitate a search for genetic underpinnings of individual variation in vulnerability to circadian misalignment, maladaptive sleep-wake behavior, and sleep disorders.
Bread wheat producing grain in which the pericarp is purple is considered to be a useful source of dietary anthocyanins. The trait is under the control of the Pp-1 homoealleles (mapping to each of the group 7 chromosomes) and Pp3 (on chromosome 2A).

Here, TaMyc1 was identified as a likely candidate for Pp3. The gene encodes a MYC-like transcription factor. In genotypes carrying the dominant Pp3 allele, TaMyc1 was strongly transcribed in the pericarp and, although at a lower level, also in the coleoptile, culm and leaf. The gene was located to chromosome 2A. Three further copies were identified, one mapping to the same chromosome arm as TaMyc1 and the other two mapping to the two other group 2 chromosomes; however none of these extra copies were transcribed in the pericarp.

Analysis of the effect of the presence of combinations of Pp3 and Pp-1 genotype on the transcription behavior of TaMyc1 showed that the dominant allele Pp-D1 suppressed the transcription of TaMyc1.