Hengzongshu/ArticleAgent huggingface dataset:
Background Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system. Different species of mammals, as well as chicken and catfish have been found to possess strikingly different sets of these receptors. To better understand the evolutionary history of paired receptors, we extended the study of FcR-like genes in amphibian representatives Xenopus tropicalis and Xenopus laevis . Results The diploid genome of X. tropicalis contains at least 75 genes encoding paired FcR-related receptors designated XFLs. The allotetraploid X. laevis displays many similar genes primarily expressed in lymphoid tissues. Up to 35 domain architectures generated by combinatorial joining of six Ig-domain subtypes and two subtypes of the transmembrane regions were found in XFLs. None of these variants are shared by FcR-related proteins from other studied species. Putative activating XFLs associate with the FcRγ subunit, and their transmembrane domains are highly similar to those of activating mammalian KIR-related receptors. This argues in favor of a common origin for the FcR and the KIR families. Phylogenetic analysis shows that the entire repertoires of the Xenopus and mammalian FcR-related proteins have emerged after the amphibian-amniotes split. Conclusion FcR- and KIR-related receptors evolved through continual species-specific diversification, most likely by extensive domain shuffling and birth-and-death processes. This mode of evolution raises the possibility that the ancestral function of these paired receptors was a direct interaction with pathogens and that many physiological functions found in the mammalian receptors were secondary acquisitions or specializations.
Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic variation useful for properly responding to agriculture needs in light of ongoing climate changes. Evolutionary processes that occur in response to extreme environmental conditions could also be better understood using adapted local populations. Herein, different evolutionary histories for two of the world northernmost native cattle breeds from Russia were investigated. They highlighted Kholmogory as a typical taurine cattle, while Yakut cattle separated from European taurines ~5,000 years ago and contain numerous ancestral and some novel genetic variants allowing their adaptation to harsh conditions of living above the Polar Circle. Scans for selection signatures pointed to several common gene pathways related to adaptation to harsh climates in both breeds. But genes affected by selection from these pathways were mostly different. A Yakut cattle breed-specific missense mutation, H100Q, in a highly conserved NRAP gene, represents a unique example of a young amino acid residue convergent change shared with at least 16 species of hibernating/cold-adapted mammals from nine distinct phylogenetic orders. This suggests a convergent evolution event along the mammalian phylogenetic tree and fast fixation in a single isolated cattle population exposed to a harsh climate.
The article considers ways to overcome corruption in the investigation and inquiry bodies by improving the course of criminology and establishing and implementing a moral and historical school. Named origins and pioneers of the ethical-historical school of criminology, given their views on the quality of justice investigator from the psychological side: integrity, strong moral convictions, skill in complex conflict situations, to remain master of their feelings and aspirations, to remain faithful to the moral principles of intolerance to evil, the pursuit of justice, ethical behavior in relations with the suspect, accused, witness, excluding physical or mental violence. It is argued that the communication of the investigator with the accused should not be based on deception and immorality; in such a profession necessary moral fortitude, and perseverance of the investigator in an atmosphere of total temptation and corruption, the ability to effectively resist illegal pressure, selfless dedication in any environment, selflessness, and humanism. The abovementioned application of the content of ethical-historical school of criminology, such as: the development and adoption of a code of ethics for CSI, the CSI oath, improvement or adoption of such codes for various categories of employees of law enforcement bodies and subjects of law enforcement; the implementation of the educational process on criminology interactive exploration of film documents on the history of the sections and fields of criminology, political processes, the Nuremberg trials, investigation and conviction of Nazi criminals and their accomplices, the investigation of disasters, terrorist attacks, the death of political and cultural figures, investigation of resonant crimes from different eras and in recent years, return to the detailed development and implementation in the training of lawyers clear criteria of admissibility of tactics; creation of self-regulating communities in state and law enforcement agencies that can be contacted in cases of corruption pressure. Scientific results demonstrate an extremely low knowledge of the recent history of criminology and the Nuremberg trials by law school graduates. The results are new and have not been published before.
The “transcultural” Seima-Turbino phenomenon relates to a wide distribution of specific objects found within the sites of different Bronze Age cultures in Eurasia, not immediately related to each other. The majority of the Seima-Turbino objects represent occasional findings, and they are rarely recovered from burial grounds.

Here, we present a new set of 14 C dates from cemeteries in western Siberia, including the key Asian site Rostovka, with the largest number of graves containing Seima-Turbino objects. Currently, the presented database is the most extensive for the Seima-Turbino complexes. Another important aspect of this work is 14 C dating of complexes within specific bronze objects—daggers with figured handles—which some researchers have related to the Seima-Turbino type objects.

The resulting radiocarbon ( 14 C) chronology for the western Siberian sites (22nd–20th centuries cal BC) is older than the existing chronology based on typological analysis (16th–15th centuries BC) and some earlier 14 C dates for the Seima-Turbino sites in eastern Europe. The 14 C dating attributes these daggers to the end of the 3rd millennium cal BC, suggesting their similar timing to the Seima-Turbino objects. Further research into freshwater reservoir offsets in the region is essential for a more reliable reconstruction of the chronology of the Seima-Turbino phenomenon and the daggers with figured handles.
So far, such a theory existed only for calculating the carrier mobility.

An exact analytical theory is developed for calculating the diffusion coefficient of charge carriers in strongly anisotropic disordered solids with one-dimensional hopping transport mode for any dependence of the hopping rates on space and energy.

The dependence of the diffusion coefficient on the electric field evidences a linear, nonanalytic behavior at low fields for all considered models of disorder. The mobility, on the contrary, demonstrates a parabolic, analytic field dependence for a random-barrier model, being linear, nonanalytic for a random-energy model. For both models, the Einstein relation between the diffusion coefficient and mobility is proven to be violated at any finite electric field. The question on whether these nonanalytic field dependences of the transport coefficients and the concomitant violation of the Einstein's formula are due to the dimensionality of space or due to the considered models of disorder is resolved in the following paper [], where analytical calculations and computer simulations are carried out for two- and three-dimensional systems.
The system of weakly coupled differential equations describing traveling waves in dispersive media is considered. The Lyapunov — Schmidt construction is used to study the branching of cnoidal-type periodic solutions. The analysis of bifurcation equations uses the group symmetry and cosymmetry of original equations. Sufficient condition for existence of the phase-shifted modes of cnoidal waves is formulated in terms of the Pontryagin's function determined by the nonlinear perturbation terms
We present an analytic model for bolometric light curves which are powered by the interaction between supernova ejecta and a dense circumstellar medium. This model is aimed at modeling Type IIn supernovae to determine the properties of their supernova ejecta and circumstellar medium. Our model is not restricted to the case of steady mass loss and can be applied broadly. We only consider the case in which the optical depth of the unshocked circumstellar medium is not high enough to affect the light curves. We derive the luminosity evolution based on an analytic solution for the evolution of a dense shell created by the interaction. We compare our model bolometric light curves to observed bolometric light curves of three Type IIn supernovae (2005ip, 2006jd, 2010jl) and show that our model can constrain their supernova ejecta and circumstellar medium properties. Our analytic model is supported by numerical light curves from the same initial conditions.
Lithosphere extension, which plays an essential role in plate tectonics, occurs both in continents (as rift systems) and oceans (spreading along mid-oceanic ridges). The northern Red Sea area is a unique natural geodynamic laboratory, where the ongoing transition from continental rifting to oceanic spreading can be observed.

Here, we analyze travel time data from a merged catalogue provided by the Egyptian and Saudi Arabian seismic networks to build a three-dimensional model of seismic velocities in the crust and uppermost mantle beneath the northern Red Sea and surroundings.

The derived structures clearly reveal a high-velocity anomaly coinciding with the Red Sea basin and a narrow low-velocity anomaly centered along the rift axis. We interpret these structures as a transition of lithospheric extension from continental rifting to oceanic spreading. The transitional lithosphere is manifested by a dominantly positive seismic anomaly indicating the presence of a 50–70-km-thick and 200–300-km-wide cold lithosphere. Along the forming oceanic ridge axis, an elongated low-velocity anomaly marks a narrow localized nascent spreading zone that disrupts the transitional lithosphere. Along the eastern margins of the Red Sea, several low-velocity anomalies may represent crustal zone of massive Cenozoic basaltic magmatism.
The reflection of probe infrared femtosecond radiation pulses from a gallium arsenide substrate of the (001) orientation in the presence of more powerful pump pulses of the same radiation with a peak power of up to 1 GW/cm2 was investigated.

A Yb3+:KY(WO4)2 laser with a central wavelength of 1 035 nm, a repetition rate of 70 MHz, a pulse duration of 130 fs, and an average power of not more than 0.9 W worked in the GaAs transparency region.

The experimental dependence of the recorded signal on the pump radiation intensity is in qualitative agreement with the model dependence for two-photon absorption. The results are important for the correct interpretation of reflectivity kinetics of quantum wells.
To search for new targets of therapy, it is necessary to reconstruct the gene network of the disease, and identify the interaction of genes, proteins, and drug compounds. Using the online bioinformatics tools we have analyzed the current data set related to the metabolism of xenobiotics, mediated by the N-acetyltransferase 2 (NAT2) gene. The study of allelic polymorphism of the NAT2 gene has a prognostic value, allowing to determine the risk of a number of oncological diseases, the degree of increased risk due to smoking and exposure to chemical carcinogens, including drugs. The aim of this study was to determine the frequencies of two important "slow" variants of the NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affected the rate of xenobiotic acetylation among the indigenous Nenets population of Northern Siberia. The obtained frequencies of polymorphic variants among the Nenets occupy an intermediate value between those for Europeans and Asians, which might indicate specific features of adaptation. We present a model of the distribution of two polymorphic variants of the NAT2 gene involved in the biotransformation of xenobiotics to study the characteristics of their metabolism in the indigenous inhabitants of Yamal.Poisk novykh misheneĭ dlia terapii dolzhen opirat'sia na rekonstruktsiiu gennoĭ seti zabolevaniia, opredelenie vzaimodeĭstviĭ genov, belkov i lekarstvennykh soedineniĭ. S pomoshch'iu onlaĭn-instrumentov bioinformatiki my proanalizirovali aktual'nyĭ na dannyĭ moment massiv dannykh, sviazannykh s metabolizmom ksenobiotikov, reguliruemykh genom N-atsetiltransferazy 2 (NAT2). Issledovanie allel'nogo polimorfizma gena NAT2 imeet prognosticheskoe znachenie, pozvoliaiushchee otsenivat' riski riada onkozabolevaniĭ i ikh povyshenie na fone kureniia i vozdeĭstviia khimicheskikh kantserogenov, v tom chisle lekarstvennykh preparatov. Tsel'iu dannogo issledovaniia iavilos' opredelenie u predstaviteleĭ korennogo nenetskogo naseleniia Severnoĭ Sibiri chastot dvukh vazhnykh “medlennykh” variantov gena NAT2 (NAT2*5, rs1801280 i NAT2*7, rs1799931), sushchestvenno vliiaiushchikh na skorost' atsetilirovaniia ksenobiotikov. Poluchennye chastoty polimorfnykh variantov u nentsev imeli promezhutochnye znacheniia mezhdu takovymi dlia evropeĭtsev i aziatov, chto, vozmozhno, obuslovleno osobennostiami ikh adaptatsii. My predlozhili model' raspredeleniia variantov gena NAT2, uchastvuiushchego v biotransformatsii ksenobiotikov, i vzaimodeĭstviĭ v sostave gennykh seteĭ dlia issledovaniia osobennosteĭ metabolizma u korennykh narodov Iamala.
This publication, in honour of Robert Kaptein's 80th birthday, contains contributions from colleagues, many of whom have worked with him, and others who admire his work and have been stimulated by his research. The contributions show current research in biomolecular NMR, spin hyperpolarisation and spin chemistry, including CIDNP (chemically induced dynamic nuclear polarisation), topics to which he has contributed enormously. His proposal of the radical pair mechanism was the birth of the field of spin chemistry, and the laser CIDNP NMR experiment on a protein was a major breakthrough in hyperpolarisation research. He set milestones for biomolecular NMR by developing computational methods for protein structure determination, including restrained molecular dynamics and 3D NMR methodology. With a lac repressor headpiece, he determined one of the first protein structures determined by NMR. His studies of the lac repressor provided the first examples of detailed studies of protein nucleic acid complexes by NMR. This deepened our understanding of protein DNA recognition and led to a molecular model for protein sliding along the DNA. Furthermore, he played a leading role in establishing the cluster of NMR large-scale facilities in Europe. This editorial gives an introduction to the publication and is followed by a biography describing his contributions to magnetic resonance.
Bronchial asthma is a multifactorial disease, with both environmental factors and genetic predisposal affecting its development. A number of gene associations have been obtained between polymorphisms of cytokine genes produced by different types of immune cells and asthma development. Interleukin-13 is involved in allergic inflammation, increased bronchial hypersensitivity, regulation of eosinophil levels and IgE production by B cells, thus making it promising for studying IL13 gene polymorphisms in bronchial asthma coupled to development of the disease.

The aim of this study was to investigate possible association between asthma and IL13 rs1800925 polymorphism in the children of Caucasian origin in Eastern Siberia. Four groups of patients with asthma were examined (mean age 12.8±1.2 years): with a controlled (n = 95) and uncontrolled course (n = 107), with severe (n = 71) and moderate severity (n = 131) diseases. The control group consisted of healthy individuals: children (n = 33) and adults (n = 102). DNA was isolated with sorbent method; genotyping was carried out using RT-PCR using specific oligonucleotide primers and fluorescent TaqMan probes. The allele and genotype frequencies were compared by the χ-square test using an online calculator. The odds ratio (OR) with a 95% confidence interval (CI) was performed to link genetic markers with pathological phenotypes.

The CT IL13 rs1800925 genotype was shown to be associated with moderate asthma and cases of uncontrollable clinical course, whereas the TT genotype was associated with severe asthma. Thus, rs1800925 polymorphism of IL13 gene (the T* variant is known to be associated with increased IL-13 expression) may be associated with bronchial asthma in children. Our data are consistent with results of other authors. E.g., Liu Z. et al. revealed an association between rs1800925 IL13 and the risk of developing asthma in children, with CT and TT genotypes being more common in the patient group. Radhakrishnan A. et al., was studied rs1800925 IL13 in adult population of Malaysia and found that the T* allele frequency in the group of patients significantly exceeds the frequency of this allele in the control group. Thus, the results of our study showed that IL13 rs1800925 polymorphism is associated with bronchial asthma in children, especially, with level of its control and severity of the disease.
The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes or their segments or particular genes within the genome, and therefore to modify the set, position and copy number of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide a possibility to introduce into genome relatively large segments of alien chromosome material, either artificially constructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transfer whole chromosomes or their fragments between different genomes within and between species. Advantages and limitations of these approaches are discussed.
Background Alpha-synuclein (α-Syn) is a small neuronal protein that has been found to be expressed throughout the brain. It has been shown that α-Syn regulates the homeostasis of monoamine neurotransmitters and is involved in various degenerative and affective disorders. There is indication that α-Syn may regulate expression of the brain-derived neurotropic factor (BDNF) which plays an important role in the mood disorders. Methodology/Principal Findings The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters (20-time winners and 20-time losers, respectively) in daily agonistic interactions. Groups of animals that had the same winning and losing track record followed by a no-fight period for 14 days (no-fighting winners and no-fighting losers) were also studied. Snca mRNA levels were increased in the raphe nuclei in the 20-time losers and in the VTA of the 20-time winners. After no-fight period Snca mRNA levels decreased in both groups. Snca mRNA levels were similar to the control level in the VTA of the 20-time losers and in the raphe nuclei of the 20-time winners. However Snca gene expression increased in these areas in the no-fighting winners and no-fighting losers in comparison with respective mRNA levels in animals before no-fight period. Bdnf mRNA levels increased in VTA of 20-time winners. Significant positive correlations were found between the mRNA levels of Snca and Bdnf genes in the raphe nuclei. Conclusions/Significance Social experience affects Snca gene expression depending on brain areas and functional activity of monoaminergic systems in chronically victorious or defeated mice. These findings may be useful for understanding the mechanisms of forming different alpha-synucleinopathies.
Analytical formulas are derived for constructing an individual bifurcation of a bronchus and the entire bronchial tree with allowance for the deviation of the inner surfaces of the bronchi from a cylindrical shape. All surfaces of the bronchial tree are matched with the second-order smoothness (there are no acute angles or ribs).

The geometric characteristics of the bronchial tree and the 'starry' shape of the inner structure are defined parametrically.
The aim of the research was to substantiate the need to take into account the factors that have a significant impact on the root rot infestation of spring wheat in the process of practical selection for resistance. The damaging factor is cereal flies which "open the gates" to all soil phytopathogens after the tillering phase.

The studies were carried out in 2019–2020 with the application of generally accepted and author's methods. Analysis of variance showed that the power of the influence of the spatial arrangement of plants on their damage by cereal flies was 30.9% and was reliable at the 1% level, while the influence of the variety itself on this indicator was almost 2 times lower (16.8%) and was significant at the 5% level.

According to the results of two years of research, the smallest, within two biological thresholds of harmfulness (PV), the infestation by root rot at the germination phase was shown by the spring wheat varieties Novosibirskaia 15 and Manu. The development of root rot in comparison with the germination phase in 2019 increased by an average of 2.5, and in 2020 - by 5.6 times. There was an equalization of differences in damage between varieties during the growing season. The correlation coefficient between the development of root rot and damage by intra-stem pests in 2019 was R = 0.744 ± 0.185 (P <0.01), in 2020 R = 0.713 ± 0.092 (P <0.01). The induction of soil suppression to phytopathogens by the rhizosphere of spring wheat varieties influenced their representation in the pathogenic complex of root rot.
Dimuonium (the bound system of two muons, the ${\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$-atom system) has not been observed yet. In this paper we discuss the electromagnetic production of dimuonium at RHIC and LHC in relativistic heavy ion collisions. The production of parastates is analyzed in the equivalent photon approximation. For the treatment of orthostates, we develop a three-photon formalism. We determine the production rates at RHIC and LHC with an accuracy of a few percent and discuss problems related to the observation of dimuonium.
The axially symmetric open mirror trap is considered as a neutron source for the hybrid thorium reactor. Plasma parameters are optimized in order to achieve the maximum neutron yield in the volume surrounded by the subcritical fuel assembly while meeting the stability criteria. For plasma consisting of equal amounts of deuterium and tritium isotopes, in the fuel assembly region, the neutron yield was found to be 0.6 × 10 17 n/s at an input power of 20 MW, and it will increase to 2.6 × 10 17 n/s if the input power increases two times. In optimal regimes, the plasma parameters were close to those achieved in experiments at the GDT facility.