Hengzongshu/ArticleAgent huggingface dataset:
Actin is related to main structural proteins in eukaryotes. In opposite to muscle alpha-actin, beta-actin is expressing in all types of cells. The constant reorganization of actin cytoskeleton takes place in non-muscle cells. Fibrillar actin, organized by globular monomers, interacts with the actin-binding proteins. Alpha-actinin forms a transverse links in actin fibrillar network, as well as concentrates in the fields of focal contacts. Tropomyosin is related to regulatory components of beta-actin, and due to the expense of longitudinal localization of the molecule in the groove of actin microfilament, stereochemically shields the sites of other actin-binding proteins. The most important function of actin cytoskeleton is the participation in the transportation of vesicles with aquaporins of second type in principal cells of an epithelium of collecting ducts in renal medulla. Vasopressin is stimulating the release of aquaporin tetramers from cytoplasmic store to apical plasmatic membrane. The participation and role of separate cytoskeleton proteins in the process of aquaporin trafficking and forming additional pores for water stays a poorly studied place in the molecular physiology of kidney. We explored the osmoregulatory action of prolonged hydration and dehydration on the protein composition of actin cytoskeleton in rats depending on the presence or absence of the actively expressing vasopressin gene in the genome. We found that the efficiency of the renal concentrating system, controlled by vasopressin, depends on expression of actin-binding proteins in the renal medulla. On the background of a stable level of inner cellular beta-actin, a change of expression an alpha-actinin and tropomyosin is observed. Dehydration of the organism is accompanied by essential reducing of alpha-actinin. In the absence of vasopressin, reduction of alpha-actinin has a smaller amplitude. The presence of the normal vasopressin gene in the genome, regardless of transitory expression level and secretion of hormone, is a factor of lower tropomyosin in the kidney. The most probable molecular mechanism of changing the expression of the genes for alpha-actinin and tropomyosin is transduction of the V2-mediated vasopressin hormonal signal to protein kinase A, phosphorylation of the cAMPresponsible transcriptional factor CREB, and nuclear CREB interaction with gene CRE sites sensitive to it.
For any given graph G, consider the graph Ĝ which is a cone over G. We study two important invariants of such a cone, namely, the complexity (the number of spanning trees) and the Jacobian of the graph.

We prove that complexity of graph Ĝ coincides with the number of rooted spanning forests in G and the Jacobian of Ĝ is isomorphic to the cokernel of the operator I + L(G), where L(G) is the Laplacian of G and I is the identity matrix. As a consequence, one can calculate the complexity of Ĝ as det(I + L(G)).

As an application, we establish general structural theorems for the Jacobian of Ĝ in the case when G is a circulant graph or cobordism of two circulant graphs.
The electrical conductivity of graphene materials is strongly sensitive to the surface adsorbates, which makes them an excellent platform for the development of gas sensor devices. Functionalization of the surface of graphene opens up the possibility of adjusting the sensor to a target molecule.

Here, we investigated the sensor properties of fluorinated graphene films towards exposure to low concentrations of nitrogen dioxide NO2. The films were produced by liquid-phase exfoliation of fluorinated graphite samples with a composition of CF0.08, CF0.23, and CF0.33. Fluorination of graphite using a BrF3/Br2 mixture at room temperature resulted in the covalent attachment of fluorine to basal carbon atoms, which was confirmed by X-ray photoelectron and Raman spectroscopies. Depending on the fluorination degree, the graphite powders had a different dispersion ability in toluene, which affected an average lateral size and thickness of the flakes.

The films obtained from fluorinated graphite CF0.33 showed the highest relative response ca. 43% towards 100 ppm NO2 and the best recovery ca. 37% at room temperature.
The dependence between the shear stress and integral flow parameters such as fluid flow rate still remains unclear for different microchannel geometries.

We present results of the numerical simulation of the 3D fluid flow in a microchannel with a rectangular cross section. Basing on the experimental measurements of the pressure drop the fluid flow and the shear stress are analyzed in detail giving the correlations for the friction factor.

The results show that the shear stress for a numerical calculation can be estimated using friction factor from the well-known formula with a slight deviation due to wall and corner effects which can be important with the reduction of microchannel size.
Among the models that become more and more popular in behavioral neuroscience are biosocial models, which allow studying the consequences of chronic social conflicts and social stress in animals. The sensory contact model appears to represent one of such models. Repeated experience of aggression or social defeats in daily agonistic interactions in male mice of different strains leads to the formation of opposing kinds of social behavior: one attributable to winners (aggressors) and another attributable to losers (defeated males, victims of aggression). A large variety of behavioral pathologies which develop in male mice in these conditions (anxious depression, catalepsy, social withdrawal, pronounced aggression, anxiety, hyperactivity, cognitive disturbances, anhedonia etc.), which are accompanied by somatic changes (reduced gonad function, psychogenic immune deficiency etc), suggest that this approach could be used for different aims of biomedical studies. Putative mechanisms of release and maintenance of aggressive and submissive behaviors in male mice under the sensory contact model, criteria of correct application, basic experimental setups and problem of the control, methodical capabilities and potentials of the sensory contact model applications are discussed in this paper.
Any vital activities of the cell are based on the ribosomes, which not only provide the basic machinery for the synthesis of all proteins necessary for cell functioning during growth and division, but for biogenesis itself. From this point of view, ribosomes are self-replicating and autocatalytic structures.

In current work we present an elementary model in which the autocatalytic synthesis of ribosomal RNA and proteins, as well as enzymes ensuring their degradation are described with two monotonically increasing functions. For certain parameter values, the model, consisting of one differential equation with delayed argument, demonstrates both stationary and oscillatory dynamics of the ribosomal protein synthesis, which can be chaotic and hyperchaotic dependent on the value of the delayed argument.

The biological interpretation of the modeling results and parameter estimation suggest the feasibility of chaotic dynamics in molecular genetic systems of eukaryotes, which depends only on the internal characteristics of functioning of the translation system.
A search for pair production of the supersymmetric partners of the Higgs boson (higgsinos) in gauge-mediated scenarios is reported. Each higgsino is assumed to decay to a Higgs boson and a gravitino.

Two complementary analyses, targeting high- and low-mass signals, are performed to maximize sensitivity. The two analyses utilize LHC pp collision data at a center-of-mass energy √s=13 TeV, the former with an integrated luminosity of 36.1 fb⁻¹ and the latter with 24.3 fb⁻¹, collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing missing transverse momentum and several energetic jets, at least three of which must be identified as b-quark jets.

No significant excess is found above the predicted background. Limits on the cross section are set as a function of the mass of the higgsino in simplified models assuming production via mass-degenerate higgsinos decaying to a Higgs boson and a gravitino. Higgsinos with masses between 130 and 230 GeV and between 290 and 880 GeV are excluded at the 95% confidence level. Interpretations of the limits in terms of the branching ratio of the higgsino to a Z boson or a Higgs boson are also presented, and a 45% branching ratio to a Higgs boson is excluded for m_higgsino ≈ 400 GeV.
Three samples of vertical-cavity surface-emitting laser diodes (VCSEL) designed by Vixar Inc. are studied. The central wavelength of the lasers is about 894.6 nm (D1 line of cesium). The threshold currents of laser generation are measured. The laser injection current is modulated at microwave frequency about 4.596 GHz that is a half of Cs ground- state hyperfine splitting frequency. Dependence of phase modulation index of laser radiation on microwave power is determined. The observed deviations of laser properties from sample to sample are compared to other works. A particular attention is paid to observation of additional optical frequencies (ghost modes) in the laser spectra, having the same polarization as the main spectral sidebands. This effect can harm metrological characteristics of various quantum devices where VSCELs are nowadays used. The optimal regimes of laser performance to avoid generation of the ghost modes are found. Also, asymmetry of the spectra caused by a residual amplitude modulation is measured. The results can be important for creation of various VCSEL-based quantum devices (atomic clocks, magnetometers).
First imlementation of blockchain technology was appeared in 2008, and 12 years later more than 2000 different implementations of it have appeared.After deep analysis we found that approaches for development blockchain technologies is fragmented, there are no common system of concepts and general model of technology.In this article we want to propose the general universal model and system of concepts for the blockchain technology irrespective of differenced of some implementations.Our approach is based on a technical analysis of the popular blockchains.The results of this work can be used by architects of new blockchains implementstions, by researchers to achieve theirs goals and also in educational process.
A new measuring electronics channel with FADC is proposed for the electromagnetic calorimeter of the SND detector, taking data at e+e− collider VEPP-2000. This system is intended to raise detection efficiency of the low-speed anti-neutrons, produced in e+e−→n anti-n reaction. The proposed channel provides time resolution of about 1 ns.
Here, we show that several aging related genes may serve as the genetic risk factors for cervical, esophagus and colorectal cancers.

We examined the genes involved in the processes of xenobiotics detoxification (GSTM1 and GSTT1), DNA repair (XRCC1, XRCC3, hMLH1), cell cycle regulation and apoptosis (CCND1, TP53, DCC).

The study results will lead to development of screening for detection of individuals susceptible to esophageal, cervical and colorectal cancers. Introduction of the screening programs will allow the early and effective preventive measures that will reduce cancer incidence and mortality in Kazakhstan.
This paper is a part of a research on diaries written in French and Russian by Olga Davydova (1813-1876) which are located in the Scientific Technological Library of Novossibirsk. Amongst 20 copybooks, five are in French. They are authorized and proofed copies of originals, in which we can distinguish the author, the copyist, the checker and the corrector, using the analysis of errors and corrections in the text. In this paper we present the level of correctness in French, typical errors and transcoding markers between French and Russian, with some elements of others languages of the author. Our conclusions are that the people from O.I. Davydova's social circle didn't use language switching and their level of French, as also English and German, was quite high, not only because of their early learning (the so-called "gouvernante method") but also because of lifelong learning, reading and travelling.
We discuss the process $p+p\to h_1+h_2+X$, where the identified hadrons $h_1$ and $h_2$ have large transverse momenta and are produced in high-energy proton-proton collisions with a large rapidity gap between them.

In this case the (calculable) hard part of the reaction receives large higher order corrections $\sim α^n_s\ln^n Δy$, which can be accounted for in the BFKL approach.

Specifically, we describe in the next-to-leading order the calculation of the vertex (impact-factor) for the inclusive production of the identified hadron.
In crosses of wild and cultivated peas (Pisum sativum L.), nuclear-cytoplasmic incompatibility frequently occurs manifested as decreased pollen fertility, male gametophyte lethality, sporophyte lethality. High-throughput sequencing of plastid genomes of one cultivated and four wild pea accessions differing in cross-compatibility was performed. Candidate genes for involvement in the nuclear-plastid conflict were searched in the reconstructed plastid genomes. In the annotated Medicago truncatula genome, nuclear candidate genes were searched in the portion syntenic to the pea chromosome region known to harbor a locus involved in the conflict. In the plastid genomes, a substantial variability of the accD locus represented by nucleotide substitutions and indels was found to correspond to the pattern of cross-compatibility among the accessions analyzed. Amino acid substitutions in the polypeptides encoded by the alleles of a nuclear locus, designated as Bccp3, with a complementary function to accD, fitted the compatibility pattern. The accD locus in the plastid genome encoding beta subunit of the carboxyltransferase of acetyl-coA carboxylase and the nuclear locus Bccp3 encoding biotin carboxyl carrier protein of the same multi-subunit enzyme were nominated as candidate genes for main contribution to nuclear-cytoplasmic incompatibility in peas. Existence of another nuclear locus involved in the accD-mediated conflict is hypothesized.
Permafrost structure of Samoylov island coastline was determined with geological and geophysical methods.

Geoelectrical model based on electrical resistivity tomography and ground penetrating radar data was compared with geological observations. Structure of contact between different types of frozen deposits was determined, influence of river water on permafrost (talik borders were determined) was estimated, ice wedges of different thickness were localized.

Results of the study could be useful in permafrost research in the region because studied objects are typical in Lena delta.
Hypoglycemia has been recognized as a risk factor for diabetic vascular complications and cognitive decline, but the molecular mechanisms of the effect of hypoglycemia on target organs are not fully understood.

In this work, gene networks of hypoglycemia and cardiovascular disease, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, cognitive decline, and Alzheimer’s disease were reconstructed using ANDSystem, a text-mining-based tool. The gene network of hypoglycemia included 141 genes and 2467 interactions. Enrichment analysis of Gene Ontology (GO) biological processes showed that the regulation of insulin secretion, glucose homeostasis, apoptosis, nitric oxide biosynthesis, and cell signaling are significantly enriched for hypoglycemia.

Hypoglycemia-related genes were overrepresented in the gene networks of diabetic complications and comorbidity; moreover, 14 genes were mutual for all studied disorders. Eleven GO biological processes (glucose homeostasis, nitric oxide biosynthesis, smooth muscle cell proliferation, ERK1 and ERK2 cascade, etc.) were overrepresented in all reconstructed networks. The obtained results expand our understanding of the molecular mechanisms underlying the deteriorating effects of hypoglycemia in diabetes-associated vascular disease and cognitive dysfunction.
This article examines the texts of the Indo-European tradition, which narrate about the myths of the origin of different peoples. Thus, a segment of the Anglo-Saxon runic series correlates with Tacitus’s description of the origin of the Ingaevon tribe. As a result, the parameters of the ethnically derived text are reconstructed. The parameters explain the choice of the sequence of the runes of the Anglo-Saxon futhork. The restored text testifies that the Ingaevons, who had the totem deity Ing, lived on the shores of the Ocean, and this was their homeland. Ethnogonic texts also tell about the correlation of totem and ethnonym in past eras. The German influence on the choice of the ethnonym “Rus”, determined by the alliterative connection of the name of the country with the name of Rurik’s tribe, has been explained. The “Rurikids” ethnonym itself came from the name of the Rhos tribe. Many ethnogonic texts are associated with sacrificial rituals. In this context, of interest is the name “Italia”, which takes its origin in the sacred texts of the high sacred style. The most ancient Indo-European inscription in the Lusitanian language, written in a high style and telling about the origin of the Veaminikori tribe, is analyzed. The names of sacred animals are opposed to the profane names in the Latin prayer to the god Mars. The souuitaurilia prayer bears witness to the repertoire of sacrificial texts about dairy animals. As a result, it becomes clear that the name “Italy” is derived from the name “uitulus” in a high sacred style. Thus, the thematic contours of Indo-European texts containing ethnogonic myths about the origin of peoples are revealed. The boundaries between cultures are erased, and the Indo-European prototext comes to the fore, giving impetus to the genesis of ethnonyms, the naming of totems, as well as the names of their own tribal leaders. In the end, we can conclude that the sacred names of young dairy animals are represented in the Lusitanian language. In the rite of sacrifice, the scale of high style is attested. The name “Italia” refers precisely to the solemn sacred layer of vocabulary, but already acts as the implicit name of a Latin prayer to the god Mars. The practice of giving names incorporated rules, which vary from tradition to tradition. Attention is drawn to the special nature of ethnogonic texts that shed light on the origin of peoples. Cultural boundaries can be the indicator that generates recognizable patterns that migrate from culture to culture
In this paper, we consider an unstudied problem of approximation of an observed pulse train by by a quasiperiodic signal generated by a pulse with a given pattern (reference) shape. The quasiperiodicity allows variation of time intervals between repetitions of the pattern pulse, as well as nonlinear expansions of the pattern in time. Such inverse problems are common in electrocardiogram (ECG) and photoplethysmogram (PPG) features extraction.

The following two variants of the problem are considered. In the first variant, the number of the pulse repetitions is unknown, while in the second one, that number is given.

The polynomial-time solvability of the both variants of the problem is constructively proved.
To identify genetic markers of risk for ST-elevated myocardial infarction (STEMI).

The study included 210 patients (119 men, 91 women) with STEMI, hospitalized from December 21, 2016 to June 16, 2017 The average age of men was 55,5±9,5 years, women — 57,5±9,1 years. The diagnosis of STEMI was verified according to the criteria of the European Society of Cardiology (2015, 2017). During hospitalization, patients underwent clinical and instrumental examination, stipulated by medical care standards and clinical guidelines We also conducted a genetic study of single nucleotide polymorphisms (SNPs), which showed their association with the risk of coronary artery disease (CAD) and acute myocardial infarction (AMI) according to the GWAS: rs2820315 of the LMOD1 gene (Leiomodin 1, mapped on chromosome 1), rs9349379 of the PHACTR1 gene (regulator 1 of actin and phosphotase, localized on chromosome 6p241), rs867186 of the PROCR gene (Protein C receptor, located on chromosome 20q11.22), rsi1799883 of the FABP2 gene (Fatty acid-binding protein 2, located on chromosome 4q26). Statistical data analysis was performed using the SPSS 170.5 software package and authorial odds ratio (OR) calculator.

Carriage of the CC genotype of rs2820315 polymorphism of the LMOD gene is associated with an increased risk of STEMI by 1,87 times (95% CI 1,2862,722, p=0,016). Carriers of the CT genotype of rs2820315 polymorphism have a reduced risk of STEMI (OR 0,633; 95% CI 0,436-0,918, p=0,016). In order to identify risk groups for STEMI development, the study of the rs2820315 polymorphism of the LMOD gene is recommended. This will define the high-risk group for STEMI for developing of personalized programs for primary and secondary prevention of cardiovascular events in practical health care, which will contribute to reducing of STEMI mortality.
A pulsed source for production of metal atoms and their oxide compounds in a supersonic expansion is described. The design utilizes a simple pulsed valve and produces a concentration of 106–107atomspercm−3 of the desired metal atoms in a molecular beam. Depending on the carrier gas used, metal compounds at similar concentration levels can also be produced.
This paper presents the results of research on the regularities of the formation of carbon nanofibrous materials, as well as the influence of the composition of the model mixture of hydrocarbons С1–С4 on the morphological features and textural characteristics of the resulting carbon nanofibres (CNF). One of the most urgent issues faced by the oil and gas industry is how to increase the processing depth of associated petroleum gas (APG). In the Russian Federation alone, the annual economic losses from unutilised APG during processing are estimated at 2 billion dollars. It is known that the composition of APG can vary greatly, depending on the oil and gas field. In particular, the methane concentration, the main component of natural gas and associated gas, varies from 25 to 95 vol.%. In this study, we sought to identify the main factors that determine the morphology and structure of CNF, and to develop approaches in processing actual hydrocarbon mixtures to produce a carbon product with the desired or predictable characteristics. Such an approach can serve as a basis for resource-saving catalytic technology utilizing C1–C4 hydrocarbons that are currently disposed of as post-combustion flare gas. The research results clearly demonstrate that the morphology and texture of the carbon materials obtained by the decomposition of hydrocarbon mixtures depend on the composition of the reaction gas. The key components in this case are methane and the resultant hydrogen: their relationship at a specific temperature determines the direction of the reversible reaction of carbon hydrogenation: С + 2H2 = СH4. The decisive factor in the decomposition of hydrocarbons yielding carbon materials is the degree of deviation of the methanation reaction from equilibrium which can be influenced in two ways. The addition of hydrogen to the reaction gas promotes the driving force of the carbon hydrogenation reaction, resulting in defective high-surface carbon fibres. Increasing the concentration of methane in the reaction gas composition, in contrast, reduces the driving force of methanation until the process is suppressed, which promotes a more structured form of the CNF, without defects.
A class of linear time-delay systems with periodic coefficients and a large parameter is studied. We establish conditions under which the zero solution is asymptotically stable. This result allows us to study the asymptotic stability of the zero solution to the time-delay systems without spectral methods and Lyapunov-Krasovskii functionals.