Hengzongshu/ArticleAgent huggingface dataset:
Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.

Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.

Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance. Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.
Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from Standard Model multijet production.

This Letter describes a new search for dijet resonances where this limitation is overcome by recording only the event information calculated by the jet trigger algorithms, thereby allowing much higher event rates with reduced storage needs. The search targets low-mass dijet resonances in the range 450-1800 GeV. The analyzed dataset has an integrated luminosity of up to 29.3 fb$^{-1}$ and was recorded at a center-of-mass energy of 13 TeV.

No excesses are found; limits are set on Gaussian-shaped contributions to the dijet mass distribution from new particles and on a model of dark-matter particles with axial-vector couplings to quarks.
A theoretical framework is proposed to describe the spin dynamics driven by coherent spin mixing at level anti-crossings (LACs). We briefly introduce the LAC concept

and propose to describe the spin dynamics using a vector of populations of the diabatic eigenstates. In this description, each LAC gives rise to a pairwise redistribution of eigenstate populations, allowing one to construct the total evolution operator of the spin system. Additionally, we take into account that in the course of spin evolution a "rotation" of the eigenstate basis case take place.

The approach is illustrated by a number of examples, dealing with magnetic field inversion, cross-polarization, singlet-state nuclear magnetic resonance and parahydrogen-induced polarization.
We construct an effective four-dimensional model by compactifying a ten-dimensional theory of gravity coupled with a real scalar dilaton field on a time-dependent torus. The corresponding action in four dimensions is similar to the action of K-essence theories. This approach is applied to anisotropic cosmological Bianchi type VI(h=-1) model for which we study the classical coupling of the anisotropic scale factors with the two real scalar moduli produced by the compactification process. The classical Einstein field equations give us a hidden symmetry, corresponding to the equality between two radii B=C, which permits us to solve exactly the equations of motion. One relation between the scale factors (A,C) via the solutions is found. With this hidden symmetry, then we solve the FRW model, finding that the scale factor goes to B radii. Also the corresponding Wheeler-DeWitt (WDW) equation in the context of Standard Quantum Cosmology is solved, building a wavepacket when the scalar fields have a hyperbolic behavior, obtaining some qualitative results when we analyze the projection plane to the wall formed by the probability density. Bohm’s formalism for this cosmological model is revisited too.
The paper provides results of the field-geological information analysis in order to evaluate the current development stage of reservoir Yu 1 of the Verkh-Tarskoe oilfield. The main recoverable asset is currently in development phase III (declining production). The total well stock consists of 175 wells, of which 134 are producing.

The monthly volume of water injection into the reservoir pressure maintenance (RPM) system reaches 100,000 m3, and fluid production is about 170,000 m3 with average water flooding of producing wells is 90.4%. The structures with complex geometry that formed within the hydrodynamic field where the deep pressure sinks are associated with production wells, and piezomaxima with injection wells.

Given the multi-facies pattern of the sandstone depositional environments and secondary processes of rocks metamorphism during catagenesis, the target reservoir has a complex structure and its study in greater detail will require building a new geological model of the oilfield and more precise definition engineering to achieve maximum recovery.
The reactions of the tetrahedral diphosphorus [Cp2Mo2(CO)4(η2-P2)] (1; Cp = C5H5) complex with Ag[Al{OC(CF3)3}4] (AgTEF) (A) and Ag[FAl{OC(C6F5)(C6F10)}3] (AgFAl) (B) were studied.

The first reaction led to the formation of the [Ag2(η2-1)2(η1:η1-1)2][TEF]2 (2) dimer and the [Ag2(η1:η1-1)3] n [TEF]2n (3) coordination polymer, whereas the second reaction afforded the [Ag2(η1:η1-1)2(η1-CH2Cl2)2(η2-C7H8)2][FAl]2 (4) or the [Ag2(η2-1)2(η1:η1-1)2][FAl]2 (5) dimer and the [Ag2(η1:η1-1)4] n [FAl]2n (6) coordination polymer.

In each case, the products obtained depended on the ratio of the reactants and/or the synthetic procedure.
A systematic computational study focused on searching for the global minima and low‐lying isomers of the Li 4 E 8 (E = P, As, Sb, Bi) series of clusters is reported.

The global‐minimum structures of Li 4 P 8 , Li 4 As 8 , and Li 4 Sb 8 as well as one of the lowest‐lying Li 4 Bi 8 isomers were found to contain a realgar‐type [E 8 ] 4– unit, which is a rare Zintl anion.

Increased stability of this skeleton allows its presence to be expected in more complex chemical compounds containing group 15 elements with appropriate stoichiometry.
Observations of exotic structures in the J/ψp channel, which we refer to as charmonium-pentaquark states, in Λ0b→J/ψK−p decays are presented.

The data sample corresponds to an integrated luminosity of 3 fb−1 acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude analysis of the three-body final state reproduces the two-body mass and angular distributions. To obtain a satisfactory fit of the structures seen in the J/ψp mass spectrum, it is necessary to include two Breit-Wigner amplitudes that each describe a resonant state.

The significance of each of these resonances is more than 9 standard deviations. One has a mass of 4380±8±29 MeV and a width of 205±18±86 MeV, while the second is narrower, with a mass of 4449.8±1.7±2.5 MeV and a width of 39±5±19 MeV. The preferred JP assignments are of opposite parity, with one state having spin 3/2 and the other 5/2.
We present the first direct search for lepton flavour violating muon decay mediated by a new light particle X, μ⁺ → e⁺X, X → γγ. This search uses a dataset resulting from 7.5×10¹⁴ stopped muons collected by the MEG experiment at the Paul Scherrer Institut in the period 2009–2013.

No significant excess is found in the mass region 20–45 MeV/c² for lifetimes below 40 ps

and we set the most stringent branching ratio upper limits in the mass region of 20–40 MeV/c², down to O(10⁻¹¹) at 90% confidence level.
Transformations of nitrogen and hydrogen defects in natural octahedral and cuboid diamonds after multi-stage annealing at P = 6 GPa and T = 2200°C are presented.

It has been observed that nitrogen aggregation from A- to B-defects in octahedral diamonds has gradually increased. This transformation of nitrogen has proceeded more rapidly in cuboid diamonds. Unlike octahedral diamonds, cuboid diamonds show a considerable increase in the intensity of the primary hydrogen-related peaks after the annealing. The magnitude to which peak 3107 cm–1 is increased after annealing has been found to be correlated with the total nitrogen content in cuboid diamonds.

One may confirm that most of the cuboid diamonds characterized by a low nitrogen aggregation state were not annealed over a long period at mantle conditions and their formation occurred shortly before transportation to the Earth’s surface. This supports the suggestion that the vibrational system with a primary line at 3107 cm–1 corresponds to a C-H vibration bonded to some form of aggregated nitrogen.
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons.

We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics.

Among the 120 reviews are many that are new or heavily revised, including a new review on Machine Learning, and one on Spectroscopy of Light Meson Resonances. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 97 review articles. Volume 2 consists of the Particle Listings and contains also 23 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print, as a web version optimized for use on phones, and as an Android app.
Electronic configuration of chemically bound atoms at the surface, including adsorbed species, or in the bulk of a solid contains a set of natural traps for energy absorption provided by valence band transitions or plasmon oscillations. The core level excitation of any origin is generally coupled with those traps, forming a multichannel route for nonradiative energy dissipation. Using an example of Pt and graphite-based materials, the study shows experimental tracing over these channels by means of elastic electron scattering and X-ray photoelectron spectroscopy. As a complement to the experimental data, calculations of the density of states provide information on chemical behavior and local geometry of the atoms in a sample.
The publication presents materials of the funeral necropolis Kyrykungir (East Kazakhstan), in which two sets of astragals with traces of coloring pigments were discovered. The design of the burials accompanying the inventory and the general archaeological context allows dating these objects from the 12th to 13th centuries BC. Data from archaeozoological analysis and SEM-EDX analysis of the painted surface of objects (alchiks) are present in the paper. The species composition of animals has been established, demonstrating a combination of astragals of both domestic and wild species. A diverse chemical composition of paints with which objects were covered, as well as cases of renewal of staining, was revealed. In the initial version, individual astragals could belong to population with different traditions of making paints, possibly from different regions. The results allow us to offer a different point of view on the phenomenon of the presence of alchiks in archaeological cultures. The range of interpretations of astragals (alchiks) finds implies not only understanding them as elements of game traditions, but also designating their complex social and cultural role in the funeral rites of the population of Eurasia in the Bronze Age.
The X-ray scattering station «Plasma» at the beamline 8 at the VEPP-4M source of synchrotron radiation was developed for dynamical measurements of deformations and mechanical stresses in tungsten during pulsed heating simulating the conditions in prospective fusion reactor. The previous results demonstrated the qualitative agreement of experimental results for single-crystal tungsten with predicted ones.

The article presents results of the measurements of the diffraction dynamic in the case of the crack formation and results of preliminary experiments on the measurements of dynamics of diffraction on the polycrystalline tungsten.
ABSTRACT Protein–protein interaction is often investigated using quantitative molecular microscopy with Förster resonant energy transfer (FRET). Here, we combined ‘linear unmixing FRET’ (lux-FRET) with the simultaneous application of a FRET-based biosensor for cAMP to investigate the oligomerization between the 5-HT7 receptor (5-HT7R, also known as HTR7) and the 5-HT1A receptor (5-HT1AR, also known as HTR1A) and its importance for cAMP signaling. We found that the 5-HT7R not only stimulates cAMP production, but also forms hetero-oligomers with 5-HT1AR, which blocks the inhibitory effect of the latter. 5-HT7R signaling, however, is not affected by this hetero-oligomerization. By modeling the kinetics of intracellular cAMP level changes in relation to the 5-HT7R:5-HT1AR stoichiometry, we were able to decipher the complex signaling characteristics of endogenous serotonin receptors in cultured hippocampal neurons. Our findings indicate that serotonergic signaling is not only modulated by the concentration of an individual receptor but also by its specific interaction with other receptors in endogenous systems. We conclude that the regulated ratio of serotonin receptors in immature and mature neurons may be critically involved in both the onset and response to treatments of psychiatric diseases, such as anxiety and depression.
The article studies the conflict between secular and church authorities over the collection of extracts from ancient manuscripts and early printed books that were found by the defenders of the Old Belief in order to prove a violation of the tradition of the Russian Church as a result of the reform of the rite and liturgical practice. Quotes from the Holy Scripture, patristic tradition, and writings of church writers constituted the 'canon of sacred texts' for the Old Believers, which was, in their opinion, equivalent to the Holy Scripture.

Fragments of texts systematized according to the subjects were copied and distributed as manuscripts. By the importance of the problem to overcome schism secular and church authorities joined forces to solve it. This was especially evident in the activities of the Moscow Council of Russian Orthodox Church in 1681–1682. An analysis of the Council Decree allowed us to conclude that in the Proposal to the Council Feodor III Alexeyevich very precisely outlined the jeopardy of the 'canon of sacred texts'. The monarch expressed worry of secular authorities about the distribution of manuscripts that increased the influence of Old Believers. In the Response of the Council, it was decided to stop the spread of 'false letters' and do it together with the secular authorities.

The article draws attention to the fact that the result of efforts of secular authorities was the execution of some Old Believers’ leaders. The church also did not stand aside and published Uvet Duhovnyi. The article shows, what position the author took with respect to the 'canon of sacred texts' and how it reflected in his text. It is concluded that Archbishop Afanasy tried to convince readers that the Old Believer`s manuscripts, 'bogomerzkie pisanye tetradki' (heretical handwritten notes), which contained extracts from the Holy Scripture and patristic tradition, had nothing in common with the true meaning of sources. Consequently, they could not argue the deviation of the reformers from the tradition of the Russian Church. The Archbishop Afanasy insisted that only 'madness' could explain the doctrine of the defenders of the Old Belief.
The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors), which are activated by olfactory stimuli (ligands). Olfactory receptors are the initial player in the signal transduction cascade producing a nerve impulse, which is transmitted to the brain. The sensitivity to a particular ligand depends on the expression level of multiple proteins involved in the process of olfactory cognition: olfactory receptor proteins, proteins that participate in signal transduction cascade, etc. The expression level of each gene is controlled by its regulatory regions, and especially, by the promoter [a region of DNA about 100-1000 base pairs long located upstream of the transcription start site (TSS)]. We analyzed single nucleotide polymorphisms using human whole-genome data from the 1000 Genomes Project and revealed an extremely high level of single nucleotide polymorphisms in promoter regions of olfactory receptor genes and HLA genes. We hypothesized that the high level of polymorphisms in olfactory receptor promoters was responsible for the diversity in regulatory mechanisms controlling the expression levels of olfactory receptor proteins. Such diversity of regulatory mechanisms may cause the great variability of olfactory cognition of numerous environmental olfactory stimuli perceived by human beings (air pollutants, human body odors, odors in culinary etc.). In turn, this variability may provide a wide range of emotional and behavioral reactions related to the vast variety of olfactory stimuli.
The transformation of powerful gravitational waves, created by the coalescence of massive black hole binaries, into electromagnetic radiation in external magnetic fields is revisited. In contrast to the previous calculations of the similar effect

we study the realistic case of the gravitational radiation frequency below the plasma frequency of the surrounding medium. The gravitational waves propagating in the plasma constantly create electromagnetic radiation dragging it with them, despite the low frequency

The plasma heating by the unattenuated electromagnetic wave may be significant in a hot rarefied plasma with strong magnetic field and can lead to a noticeable burst of electromagnetic radiation with higher frequency. The graviton-to-photon conversion effect in plasma is discussed in the context of possible electromagnetic counterparts of GW150914 and GW170104
Atrial fibrillation is one of the most common heart rhythm disorders. The most prominent risk factor for atrial fibrillation is advanced age. Population ageing contributes to an increase in both the prevalence of this pathology and socio-economic burden of the disease for society in general and the patient in particular. Adequate therapy and prevention of atrial fibrillation requires the search for novel prognostic risk markers for disease development, progression, and patients response to therapy. One of these markers is the length of telomeres structures at the ends of chromosomes that protect them from degradation during cell division. The article provides an overview of world studies, both confirming and disproving the role of leukocyte telomere length in atrial fibrillation development.
More than five decades have passed since the first single-crystal X-ray diffraction experiments at high pressure were performed. These studies were applied historically to geochemical processes occurring in the Earth and other planets, but high-pressure crystallography has spread across different fields of science including chemistry, physics, biology, materials science and pharmacy.

With each passing year, high-pressure studies have become more precise and comprehensive because of the development of instrumentation and software, and the systems investigated have also become more complicated. Starting with crystals of simple minerals and inorganic compounds, the interests of researchers have shifted to complicated metal-organic frameworks, aperiodic crystals and quasicrystals, molecular crystals, and even proteins and viruses.

Inspired by contributions to the microsymposium 'High-Pressure Crystallography of Periodic and Aperiodic Crystals' presented at the 23rd IUCr Congress and General Assembly, the authors have tried to summarize certain recent results of single-crystal studies of molecular and aperiodic structures under high pressure. While the selected contributions do not cover the whole spectrum of high-pressure research, they demonstrate the broad diversity of novel and fascinating results and may awaken the reader's interest in this topic.
The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA binding by transcription factors. In vertebrates, APEX1 knockouts are embryonic lethal, and only a handful of knockout cell lines are known. To facilitate studies of multiple functions of this protein in human cells, we have used the CRISPR/Cas9 system to knock out the APEX1 gene in a widely used non-cancer hypotriploid HEK 293FT cell line. Two stable knockout lines were obtained, one carrying two single-base deletion alleles and one single-base insertion allele in exon 3, another homozygous in the single-base insertion allele. Both mutations cause a frameshift that leads to premature translation termination before the start of the protein’s catalytic domain. Both cell lines totally lacked the APEX1 protein and AP site-cleaving activity, and showed significantly lower levels of the APEX1 transcript. The APEX1-null cells were unable to support BER on uracil- or AP site-containing substrates. Phenotypically, they showed a moderately increased sensitivity to methyl methanesulfonate (MMS; ~2-fold lower EC 50 compared with wild-type cells), and their background level of natural AP sites detected by the aldehyde-reactive probe was elevated ~1.5–2-fold. However, the knockout lines retained a nearly wild-type sensitivity to oxidizing agents hydrogen peroxide and potassium bromate. Interestingly, despite the increased MMS cytotoxicity, we observed no additional increase in AP sites in knockout cells upon MMS treatment, which could indicate their conversion into more toxic products in the absence of repair. Overall, the relatively mild cell phenotype in the absence of APEX1-dependent BER suggests that mammalian cells possess mechanisms of tolerance or alternative repair of AP sites. The knockout derivatives of the extensively characterized HEK 293FT cell line may provide a valuable tool for studies of APEX1 in DNA repair and beyond.