Hengzongshu/ArticleAgent huggingface dataset:
Purpose. To study the content of cytokines and growth factors in the intraocular fluid of patients with developed stage of primary open-angle glaucoma (POAG).

Materials and methods. 56 patients with a verified diagnosis developed stage of primary open-angle glaucomawere examined. The control group consisted of 30 patients with a diagnosis of uncomplicated cataract. A concentration of 17 cytokinesand 3 isoforms of the transforming growth factor (TGF) β was determined using a Bio-Plex Pro™ Human Cytokine 17-plex Assay and Bio-Plex Pro™ and TGFβ 3-plex Assay kit by flow-through fluorometry on a Bio-Plex 200, Bio-Rad double beam laser analyzer, USA.

Results. Astatistically significant increase was shown in the concentrations of cytokines and growth factors (interleukins (IL) 4, 6, 7, 8, 12, 17, TGFβ 1, 2, 3, macrophage inflammatory protein 1 β) in the intraocular fluid of patients with developed stage of the primary open-angle glaucoma in respect to data obtained from the study of the intraocular fluid of the persons with uncomplicated cataract, as well as a statistically significant decrease in the concentrations IL-2, IL-10, granulocyte-macrophage colony-stimulating factor. Conclusion. In the pathogenesis of primary open-angle glaucoma, the activity of the local chronic inflammatory process is determined. This is confirmed by statistically significant changes in the studied cytokines and growth factors. Increase in the concentrations of the studied representatives of the superfamily of transforming growth factors-beta, which have anti-inflammatory activity, the ability to stimulate proliferation, cell growth, synthesis of extracellular matrix proteins, etc., attests to their importance in the mechanisms of primary open-angle glaucoma development. Increase concentrations of IL-7 in the intraocular fluid of patients with primary open-angle glaucoma allows us to assume participation in the pathogenesis of the primary open-angle glaucoma of this autocrine mediator of activation of the growth of lymphatic structures.
There is a huge number of small lakes in south of West Siberia and such lakes are very useful local for climate and environmental reconstructions. The previously studied objects in the area are mostly peat-bogs and geologic sections; the lake history and natural interactions between paleoenvironmental and climate changes in the region are understudied.

Here we present results of multiproxy investigation of three lakes located in different parts of the Baraba forest-steppe region along a 300km north-south transect: Bolshie Toroki, Chany (Yarkov subbasin), and Malye Chany. Vibrational drilling technology method was used to recover undisturbed columns of lake sediments and penetrate to non-lacustrine substrata. The obtained cores were investigated basically by sedimentological and palynological analyses (with the reconstruction of vegetational cover) and radiocarbon dating, additionally we used other paleontological (diatom, ostracod, chironomid analyses), geophysical, and biogeochemical methods to obtain information about environmental and climate changes, as well as lake level, biotic, ecosystem, and geochemical changes.

This and our previous studies showed complicated picture of lake evolution histories and climate change in the south of West Siberia. According to our data most of investigated lakes (Chany, Malye Chany, Beloye, Minzelinskoye, Bolshie Toroki, and Kirek) are very young and started to form in the middle Holocene or later as marshy lowland with peaty sediments. Then they became deeper with mostly sapropel sediments.
testing the homology between each amino acid fragment from the list and proteins from the SWISS-PROT database of amino acid sequences

first, the exons with the best potential are predicted in a sequence with unknown functions and a list of potential amino acid fragments coded by these exons is formed. Second, testing the homology between each amino acid fragment from the list and proteins from the SWISS-PROT database of amino acid sequences. One protein with the best homology is chosen out of all the homologous sequences. Third, reconstruction of the exonintron structure, basing it on its homology with the chosen protein sequences

The method was tested on an independent control set (20 genes). The results were as follows: 21% of real exons were lost and 3% of non-real exons were found. This system can be used to refine the results of gene prediction systems, especially if highly homologous proteins are found in the amino acid sequence database
Every year, about six million people die from tobacco use. Respiratory epithelium is the first line of defense against exogenous invasion, in particular, harmful inhaled particles, pathogens and allergens. However, the epithelium of the respiratory tract is also a regulator of immunological and inflammatory reactions through secretion of inflammation and immune cell recruitment mediators. An important component of the pulmonary immune system is the surfactant, and, in particular, its proteins SP-A and SP-D, synthesized mainly by type II pneumocytes.

Aim . To assess the levels of surfactant proteins SP-A and SP-D in the blood of smoking patients without bronchopulmonary diseases. Materials and мethods . The study included 59 patients admitted to the department of internal medicine with hypertension. The general group was divided into subgroups: non-smoking patients ( n = 31) and healthy smokers ( n = 28). All patients underwent clinical, functional, diagnostic and laboratory tests. The content of surfactant proteins SP-A and SP-D in the blood was determined by enzyme immunoassay.

Results. The subgroups did not differ in sex, age, height, body weight, blood pressure, heart rate, respiratory rate, and the distribution of comorbidities. The subgroups differed in the platelet level; in other main parameters of complete blood count and blood biochemistry no differences were revealed. It was found that the blood levels of surfactant proteins SP-A and SP-D in the subgroup of healthy smokers were significantly higher in comparison with the subgroup of non-smoking patients. The correlation analysis revealed a direct relationship between surfactant proteins SP-A and SP-D and smoking ( R = 0.360, p = 0.006, R = 0.274, p = 0.037), a negative correlation between SP-D protein and age ( R = –0.315, p = 0.016), and a direct relationship between SP-A protein and diastolic blood pressure ( R = 0.271, p = 0.039). In the non-smoking subgroup, a negative correlation between SP-D and age ( R = –0.438, p = 0.016) and between SP-D and systolic blood pressure ( R = –0.433, p = 0.017) was identified. Conclusion. The direct relationship between higher levels of the surfactant proteins SP-A and SP-D and smoking in the group of healthy smokers is justified (inflammatory changes, structural abnormalities in the lung parenchyma under the influence of cigarette smoke). The SP-D protein is more significant in comparison with the SP-A protein in vascular wall remodeling, lung tissue matrix, oxidative lung tissue damage, and apoptosis, which explains its negative correlation with age and systolic blood pressure.
Mutations in TP53 lead to loss of function or gain of function (GOF) of the corresponding protein, p53, and have a different effect on the tumor. We aimed to determine the spectrum of TP53 mutations in BRCA1/2 associated serous ovarian cancer (HGSOC).

The study population comprised of HGSOCs with mutations in BRCA1 (78) or BRCA2 (21). Only chemo-naive and platinum-sensitive patients were included in this study. The case group of the IARC database (n = 1249) with HGSOC not stratified by BRCA status was used as a reference. A custom NGS panel was used for sequencing TP53 and mutation hot-spots of other genes, p53 expression was evaluated by immunohistochemistry for 68 cases of HGSOCs.

TP53 mutation (95) or inhibition of wild-type p53 expression (3) was observed in 98 cases. The sample with normal p53 had CDKNA1 mutations. The frequency of truncating mutations was significantly higher than in the reference cohort (30.3% vs 21.0%, p = 0.01). Most of the samples (41/68) demonstrated low (or absent) expression of p53 and 17 samples overexpressed p53. LOH was typical for TP53 nonsense mutations (14/15). In total, 68/95 samples were LOH positive and showed LOH in all tumorous cells thus indicates the driver effect of TP53 mutations. Three specimens had KRAS, BAX, APC, and CTNNB1 subclones mutations. Conclusion: High frequency of truncating mutations, the low expression of mutant p53, and the lack of oncogenes mutations indicate the low manifestation of the potential GOF properties of p53 in BRCA1/2 associated HGSOC.
The present paper discusses the method of identification (diseased/healthy) human cerebral vessels by using of mathematical model. Human cerebral circulation as a single tuned circuit, which consists of blood flow, elastic vessels and elastic brain gel tissue is under consideration. Non linear Van der Pol-Duffing equation is assumed as mathematical model of cerebrovascular circulation. Hypothesis of vascular pathology existence in some position of blood vessel, based on mathematical model properties for this position is formulated. Good reliability of hypothesis is proved statistically for 7 patients with arterial aneurysms.
The article examines the linguistic personality of the author of popular science articles through analysis of his use of argumentative means. Three articles of the journalist R. Fishman were selected as material.

The distribution of argumentative schemes (types of arguments) is considered in comparison with the average distribution in journalistic texts; some specific features of argumentative structures (ways of organizing argumentation in the text) are shown.

It was found that the author often prefers to use logical and pseudological arguments, as well as arguments demonstrating ways of obtaining knowledge, and less often – to References to an authoritative opinion. The complicated argumentative structures used by R. Fishman demonstrate the multifaceted nature of the scientific phenomena referred to in the texts; conflict, or attacking (containing counterarguments) schemes used by the author perform two functions: attracting attention and demonstrating the complexity and ambiguity of scientific phenomena. On the whole, the argumentation observed in the texts of R. Fishman indicates that the author tries to comprehend scientific knowledge for its appropriate transfer to a non-specialist reader, and does not use simpler strategies to popularize scientific knowledge.
The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.
The width of the ${f}_{1}(1285)\ensuremath{\rightarrow}{e}^{+}{e}^{\ensuremath{-}}$ decay is calculated in the vector meson dominance model. The result depends on the relative phase between two coupling constants describing ${f}_{1}\ensuremath{\rightarrow}{\ensuremath{\rho}}^{0}\ensuremath{\gamma}$ decay. The width $\mathrm{\ensuremath{\Gamma}}({f}_{1}\ensuremath{\rightarrow}{e}^{+}{e}^{\ensuremath{-}})$ is estimated to be $\ensuremath{\simeq}0.07--0.19\text{ }\text{ }\mathrm{eV}$. Direct ${f}_{1}$ production in ${e}^{+}{e}^{\ensuremath{-}}$ collisions is discussed, and the ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{f}_{1}\ensuremath{\rightarrow}{a}_{0}\ensuremath{\pi}\ensuremath{\rightarrow}\ensuremath{\eta}\ensuremath{\pi}\ensuremath{\pi}$ cross section is calculated. Charge asymmetry in the ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\eta}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ reaction due to interference between ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{f}_{1}$ and ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\eta}{\ensuremath{\rho}}^{0}$ amplitudes is studied.
It is shown in the paper that the field in question was heterogeneous and non-Gaussian.

A stochastic model based on the real data collected at the weather stations located in West Siberia and on the method of the inverse distribution function that sufficiently well reproduce different characteristics of the real field of the average daily wind chill index is proposed in this paper. I also discussed several questions related to the simulation of the field on a regular grid.

In the future, my intention is to transform the model proposed to a model of the conditional spatio-temporal field defined on a regular grid that allows one to forecast the wind chill index.
1H MRI of gases can potentially enable functional lung imaging to probe gas ventilation and other functions.

In this work, 1H MR images of hyperpolarized and thermally polarized propane gas were obtained using UTE (ultrashort echo time) pulse sequence. A 2D image of thermally polarized propane gas with ~0.9×0.9 mm2 spatial resolution was obtained in less than 2 seconds, demonstrating that even non-hyperpolarized hydrocarbon gases can be successfully utilized for conventional proton MRI. The experiments were also performed with hyperpolarized propane gas and demonstrated acquisition of high-resolution multi-slice FLASH 2D images in ca. 510 s and non slice-selective 2D UTE MRI images in ca. 2 s.

The UTE approach adopted in this study can be potentially used for medical lung imaging. Furthermore, the possibility to combine UTE with selective suppression of 1H signals from one of the two gases in a mixture is demonstrated in this MRI study. The latter can be useful for visualizing industrially important processes where several gases may be present, e.g., gas-solid catalytic reactions.
In this work, titanium carbonitrides were synthesized by self-propagating high-temperature synthesis (SHS) in nitrogen. For the first time, the synthesis of titanium carbonitrides by combustion was realized in nitrogen at atmospheric pressure. The synthesis was carried out by subjecting high-energy ball-milled titanium-carbon black powder mixtures to combustion in a nitrogen atmosphere. The influence of the ball milling time on the phase composition of the products of SHS conducted in the Ti+0.3C reaction mixture was studied. It was found that the titanium-carbon black mixtures need to be milled for a certain period of time for the combustion synthesis to yield a single-phase carbonitride product.
The GeneNet (gnw/genenet/) accumulate information on reactive oxygen species (ROS) signals and reduction/oxidation (redox) regulation of transcription factors. Redox-regulation gene network is the adaptation to oxidative stress and integrative system of local gene networks via key transcription factors. The cross-talk of signals and the interference of gene networks occur in the integrative gene network
Internal waves in the atmosphere and ocean are generated frequently from the interaction of mean flow with bottom obstacles such as mountains and submarine ridges. Analysis of these environmental phenomena involves theoretical models of non-homogeneous fluid affected by the gravity.

In this paper, a semi-analytical model of stratified flow over the mountain range is considered under the assumption of small amplitude of the topography. Attention is focused on stationary wave patterns forced above the rough terrain. Adapted to account for such terrain, model equations involves exact topographic condition settled on the uneven ground surface.

Wave solutions corresponding to sinusoidal topography with a finite number of peaks are calculated and examined.
We present a search for nine lepton-number-violating and three lepton-flavor-violating neutral charm decays of the type D0→h'−h−ℓ'+ℓ+ and D0→h'−h+ℓ'±ℓ∓, where h and h′ represent a K or π meson and ℓ and ℓ′ an electron or muon. The analysis is based on 468 fb−1 of e+e− annihilation data collected at or close to the Υ(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. No significant signal is observed for any of the twelve modes, and we establish 90% confidence level upper limits on the branching fractions in the range (1.0–30.6)×10−7. The limits are between 1 and 3 orders of magnitude more stringent than previous measurements.Received 16 May 2019Accepted 23 January 2020DOI:https://doi.org/10.1103/PhysRevLett.124.071802Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Physical SystemsCharmed mesonsPropertiesBaryon & lepton number symmetriesFlavor symmetriesParticles & Fields
This paper deals with a mathematical model of the phase transition of the first kind at the initial stage of forming drops in a liquid or in melted state in a volume of steam with a fixed charge on drops. The model of the process is represented by superposition of random diffusion and jump stochastic processes. The algorithms for solving stochastic differential equations (SDEs) of the model of processes, which form the cluster size, allow one to calculate a distribution function of drops according to their size. The kinetic approach makes possible evaluate the role of the Rayleigh capillary instability at the initial condensation stage and to employ the analysis of electrodispersion mechanisms in the production of metal and semiconductor powders.
We consider a system of differential equations with two delays, which describes the interaction between predator and prey populations.The model takes into account the age structure of populations, herewith the delay parameters denote the time that predator and prey individuals need to become adult.We consider questions of stability of equilibrium points and study asymptotic properties of solutions.We establish estimates of solutions characterizing the stabilization rate at infinity and find estimates of attraction sets.The results are obtained using modified Lyapunov-Krasovskii functionals.
A mathematical model for membrane's vibration process is used in this paper. The model is based on seeking a solution of the second-order hyperbolic differential equation.

A new inverse problem is set and investigated in two versions. In the first version the known data are as follows: the coefficient defining the phase velocity, the starting data of the Cauchy problem, the Cauchy problem solution on two given planes, derivatives of the solution along the vector being normal to these planes. The challenge has been in localizing the support of the right-hand side of the equation for vibrations. The algorithm permitting to find the bounded domain containing the unknown support was designed. In the second version the algorithm refers to the case where the coefficient defining the phase velocity is unknown but an interval of its possible values is known.

A series of runs was performed to illustrate the proposed model.
Most contemporary storage rings operate in the multibunch mode. In this case, the transverse dynamics in the presence of feedback may be complicated. Indeed, generally, the amplified signal of beam position monitor kicks all circulating bunches.

In this paper, the stability of such system with many degrees of freedom is considered.

Damping times are estimated for the simplest cases.
Aim of the study was to investigate the associations of leptin levels with cardiometabolic risk factors in overweight young people.

Material and methods. From a representative sample of the young population of the Oktyabrsky district of Novosibirsk at the age of 25–35 years (636 people), all overweight people (196 persons) and people with normal body weight (control group 197 persons) were chosen for determination of serum leptin (393 people). Study design – case-control. Overweight was determined according to body mass index (BMI) ≥ 25 kg/m 2 . Leptin levels were determined by immunofluorescence analysis (IFA) using Elisa test systems (Diagnostics Biochem Canada Inc., Canada) on an IFA analyzer Multiscan EX (Finland). For calculations, the median and interquartile range were used (Me [25; 75]).

Conclusions . Serum leptin levels are associated with cardiometabolic risk factors and metabolic syndrome in young population, and leptin levels above 6.5 ng/ml in men and 25.8 ng/ml in women are characteristic of individuals with metabolic syndrome.
Background . Ultrasound assessment of myocardial strain allows non-invasive identification of early stages of heart failure with preserved ventricular ejection fraction. A decline of the left ventricle (LV) global longitudinal strain in hypertension (HT) accompanied by LV hypertrophy (LVH) was reported in clinical samples with manifest HT. Data on the relationship between longitudinal strain and blood pressure (BP) and HT in general population is lacking. Objective . We studied the relationship between LV peak systolic global longitudinal strain ( GLS ) and strain rate ( GSR ) in subjects with high and controlled BP from a general population sample aged over 55 years. Design and methods . The cross-sectional study was based on a population cohort (HAPIEE, Novosibirsk). In a random sample (n = 416, aged 55–84 years old) we performed echocardiography and evaluated GLS and GSR of LV by speckle tracking technique. ANOVA multivariable models were applied. Results. In the studied sample, the prevalence of HT comprised 78,9 %. The mean GLS value was –18,7 ± 3,79 %, and it was lower in men than in women (–18,2 ± 3,85 % vs –19,2 ± 3,66 %, p = 0,005). The mean GSR value was –0,84 ± 0,17s –1 , and did not differ by sex. The absolute value of GLS in HT was lower than in normotensives: –18,5 ± 3,73 % vs –19,9 ± 3,42 %, p = 0,003; this difference was independent of age, sex and LV myocardial mass index (IMM), p = 0,011; but it was attenuated in a multivariable-adjusted model including body mass index (BMI). In HT groups, the GLS was the lowest among those "treated ineffectively" and significantly lower than in normotensives independently of age, sex and myocardium mass index (p = 0,008). The absolute value of GSR in HT was lower than in normotensives: –0,90 ± 0,17 s –1 vs –0,83 ± 0,17s –1 , p < 0,001; and persisted in multivariable models. GSR was the lowest among those "treated ineffectively" and significantly lower than in normotensives in multivariable models independently of age, sex, BMI and myocardial mass index (p = 0,017; 0,002). The average values of LV ejection fraction (Simpson) in all groups were above 50 % without significant inter-group differences (p = 0,904). conclusions. In the studied population sample, GLS and GSR of LV were associated with HT; however, the association between GLS and HT was largely explained by BMI. In hypertensives, the lowest GLS and GSR , as well as higher extent of LVH, were found among those treated ineffectively, which might point at the initial reduction of systolic ventricular function in HT with inadequate BP control.