Hengzongshu/ArticleAgent huggingface dataset:
Introduction. The strength of construction materials when used under cyclic loads is of great importance in design engineering. A significant number of factors that affect the fatigue resistance have predetermined the creation of numerous methods that consider such influence. Nondestructive methods that are based on the connection of the physical degradation of material with strain properties enable evaluating experimentally the fatigue properties of materials. Purpose of study: the analysis of the processes of energy dissipation and strain accumulation during the inelastic cyclic strain of samples, using the VT6 (Ti-6Al-4V) titanium alloy and the D16 (Al-Cu-Mg) aluminum alloy before and after the technological impact. The work experimentally investigates the physical processes of degradation of the VT6 and D16 alloy samples that accompany the process of fatigue failure in materials with homogeneous and inhomogeneous stress-strain states in the concentrator (in the form of a hole and a weld). Typical modes are used to reach the fatigue testing that determine the critical stress in a material sample – the stress at which physical properties (temperature, strain) change without reaching the fatigue failure of samples. Critical stress amplitudes in the cycle, based on the data obtained during the experiment and the results of mathematical simulation, are compared. The effect of stress concentrators on critical loads that a detail can withstand after a unit operation is estimated by the finite-element method (FEM). As a result, the effect of the operational and technological factors on critical stress determined by strain and temperature is estimated. Comparative tests of the VT6 and D16 alloy samples with and without stress concentrators showed that the amplitudes of critical stress decrease by more than 30% in comparison with the ones that are without stress concentrators. The low-cycle fatigue tests of the D16 alloy samples are carried out. Mathematical simulation of the cyclic strain of the samples is carried out using MSC.Marc package. The results of the cyclic loading tests, which show that the characteristics of the technological process reduce the amplitudes of the critical stress of the VT6 and D16 alloys and affect the fatigue properties of the D16 aluminum alloy, are discussed. Mathematical simulation corresponded positively to the experimental data. Such correspondence indicates the possibility of conducting qualitative numerical assessments of the beginning of the inelastic strain accumulation process in structures with stress concentrators under the cyclic stress and the increasing stress amplitude, using the typical sample made of hardening elastoplastic material.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide, with no cure. There is growing interest in mitogen-activated protein kinases (MAPKs) as possible pathogenesis-related therapeutic targets in AD. Previously, using senescence-accelerated OXYS rats, which simulate key characteristics of the sporadic AD type, we have shown that prolonged treatment with mitochondria-targeted antioxidant plastoquinonyl-decyltriphenylphosphonium (SkQ1) during active progression of AD-like pathology improves the activity of many signaling pathways (SPs) including the p38 MAPK SP.

In this study, we continued to investigate the mechanisms behind anti-AD effects of SkQ1 in OXYS rats and focused on hippocampal extracellular regulated kinases’ (ERK1 and -2) activity alterations. According to high-throughput RNA sequencing results, SkQ1 eliminated differences in the expression of eight out of nine genes involved in the ERK1/2 SP, compared to untreated control (Wistar) rats. Western blotting and immunofluorescent staining revealed that SkQ1 suppressed ERK1/2 activity via reductions in the phosphorylation of kinases ERK1/2, MEK1, and MEK2.

SkQ1 decreased hyperphosphorylation of tau protein, which is present in pathological aggregates in AD. Thus, SkQ1 alleviates AD pathology by suppressing MEK1/2-ERK1/2 SP activity in the OXYS rat hippocampus and may be a promising candidate drug for human AD.
This study aimed to test the hypothesis that immune dysfunction and the increased risk of spontaneous abortion in pregnant women with hyperandrogenia (HA) are caused by the reduced tolerogenic potential of dendritic cells (DCs) that results from elevated levels of dehydroepiandrosterone sulfate (DHEAS).
The article presents the adaptation results for "Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT)" questionnaire for early diagnosis of autism spectrum disorders (ASD) in the Russian-speaking sample

We evaluated the psychometric properties of the Russian version questionnaire: internal consistency reliability, construct validity, criterion-related validity and item discrimination

According to the results of the adaptation, BISCUIT questionnaire has good psychometric indicators, however, cutoff scores should be revised on a standardization sample with a larger number of clinical cases
This work presents result of visualisation of the characteristic combustion regimes of methane-air and syngas-air swirl-stabilized flames for an unconfined premixed burner (Re = 5000) and non-premixed combustion chamber (Re = 30000).

Equivalence ratios were selected to have nearly equal values of the laminar flame propagation speed for the methane/air and syngas/air flames. Visualization for the premixed combustion for the model swirl burner revealed a similar shape of the flames for all mixtures.

In contrast, during combustion of methane and syngas in the combustion chamber in the case of combustion in the combustion chamber, these differences in parameters cause completely visually diverse combustion modes.
The experiments by Gregor Mendel, which formed the background for genetics, were performed with the characters of intraspecific difference (alternative characters). Mendelian protein-coding genes are responsible for these characters. Until recently, these genes were regarded as the only and main hereditary factors responsible for ontogenesis and phylogenesis.

The review outlines the information about another category of biological characters (the characters of intraspecific similarity) and, correspondingly, of a special category of genes responsible for these characters (ontogenes). The study into mutations of ontogenes in drosophila experiments suggests that

(1) ontogenes control the construction of cell ensembles and trigger protein-coding genes in cells; (2) the program of individual development is encoded in ontogenes and "edited" in germline cells; (3) ontogenes fulfill a regulatory function without any contacts and chemical intermediaries, which suggests a kind of biophysical activity; and (4) two categories of cells—stem cells and terminally differentiated cells—correspond to these two categories of genes. Ontogenes are active in stem cells and protein-coding genes, in terminally differentiated cells.
In the present review the analysis of the world literature devoted to the problem of familial hypercholesterolemia at a young age was carried out. Its prevalence both on the territory of the Russian Federation and on the territory of the whole world is discussed. The problem of increased risk of age-dependent cardiovascular events is analyzed.

The results of research examining the effectiveness of existing risk assessment scales at a young age, as well as the phenotypic diagnostic criteria, including DLCNC, Simon Broome, MEDPED and Japanese criteria are presented. The information on the topic from publications based on PubMed and Google Scholar data were used.

An overview of studies aimed at investigation of the drug and non-drug therapy positive effect on cholesterol levels is given. Innovative methods of hypercholesterolemia correction were announced.
The fungal pathogen Cochliobolus sativus Drechs. Ex Dastur, anamorph Bipolaris sorokiniana (Sacc.) Shoemaker is one of the most common barley pathogens worldwide and causes spot blotch and root rot in barley. Spot blotch is considered to be the major biotic stress hampering the commercial production of barley. During high disease severity, which occurs in the northwestern region of Russia once every three to four years, yield losses for barley may reach 40%. An increase in common root rot severity results in yield losses that can reach 80%. The goal of the current study was to identify significant markers that can be employed as diagnostic DNA markers to breed C. sativus pathogen-resistant varieties of barley. In 94 spring barley cultivars and lines, the resistance of seedlings and adult plants to the impact of C. sativus on their leaves and roots was investigated. Five genomic regions associated with resistance to Spot blotch were identified (on chromosome 1H (50–61.2 cM), 2H (68.7–69.68 cM), 3H (18.72–26.18 cM), 7H (7.52–15.44 cM)). No significant loci were determined to be associated with root rot. According to obtained data, 11 significant SNPs were converted into KASP markers and 6 markers located on chromosome 3H were determined to possess good accuracy and the potential to be employed in marker-assisted selection.
Realistic evaluation of the investment attractiveness of the financed project is the basis for the successful functioning of a venture investor. At the same time, investors often have to act in conditions of a severe lack of information, especially when it comes to projects at an early stage of the life cycle. In these cases, they use multi-criteria methods for assessing investment attractiveness, often also called scoring methods. The aim of this work is to develop a methodology for assessing the investment attractiveness of innovative projects at the early stages of the life cycle, both based on an analysis of theoretical approaches in the field of venture economics, and based on an analysis of existing business practices.We have proposed a method for assessing the investment attractiveness of a project based on dividing the criteria into three macro groups (market and entry strategy, team and product). At the same time, we used a concept that allows us to interpret the value of each of the assessed parameters (seven in each macro group) as a positive or negative signal given by the project to a potential investor.An important difference between the presented methodology and others described in the professional literature is the combination of the use of theoretical models with an in-depth analysis of the criteria used in practice by various players in the venture capital market (funds, business angels, etc.), which together form the methodological basis of the work. This combination of the use of sources of information on the criteria for evaluating projects determines the scientific novelty of the study. The practical significance lies in the possibility of applying the proposed methodology both by venture investors and other actors of the venture capital ecosystem for making specific financial decisions.
Geological, mineralogical, petrochemical and geochronological data are considered for the Khairkhan dunite-troctolite-gabbro massif in the Lake zone of Western Mongolia. The massif intrude the Lower Cambrian molasse stratum and intruded by the Middle Cambrian diorite-plagiogranite bodies (507 Ma). Mineralogical, petrographic and geochemical data show typical suprasubduction characteristics: high An component of plagioclases with increased iron content of olivines, high whole-rock alumina content, low contents of titanium and alkalis, Ta, Nb, Zr and Hf minima. The layered series is characterized by a layers of orbicular gabbros, which can be considered as gabbro-gabbro mingling. At the same time, high-temperature viscous-plastic deformations are characteristic of the layered series, which cover the entire volume of the intrusion. These observations, together with geological and geochronological data related to the melting of the suprasubduction mantle in the Cambrian-Ordovician time, allow treating the Khairkhan massif as an example of syncollisional stratified gabbroids.
Мақалада жаһанды жаулаған Covid-19 пандемиясы салдарынан пайда болған күрделі экономикалық жағдай баяндалған: кедейлердің жағдайы нашарлауы аясында байлардың табысының өсуі орын алу мүмкіндігі аталды. Экономиканың түрлі салаларындағықұрылымдық өзгерістер мазмұндалған. Сарапшылардың талдаулары келтірілген: көмірсутектер нарығындағы, ауыл шаруашылығындағы, құрылыс саласындағыахуал, халыққа көрсетілген қызметтер көлемі, тұтынушылық талап-тілектері сараланған.

Мұнай бағасының Қазақстандағы өнеркәсіп өндірісіне әсері, Қазақстанның ЖІӨқалыптастыруға ауыл шаруашылығының қосқан үлесі, Құрылыс жұмыстары көлемінің өзгеру динамикасы, Халықтың қаржылай шығыстарының құрылымы келтірілген. «Қарапайым заттар экономикасы» және «Бизнестің жол картасы» бағдарламаларының маңыздылығы аталған.

Жаңа әлемдік тәртіпті қалыптастыру жағдайында жүйелік реформаларға, Ұлт жоспары мен Бес институционалдық реформаға негізделген қуатты серпін қажеттігі аталып, экономикалық дамуға бағытталған стратегиялық мақсат нақтыланған.Қолайлы экономикалық жағдай қалыптасқан жағдайда Қазақстан дағдарысқа дейінгі деңгейге оралып, 2022 жылы қалыпты өсу траекториясына жететіні болжанған.Doing Business рейтингінде Қазақстанның позициясын жақсарту үшін жүйелі жұмыстар жүргізілу мүмкіндігі қарастырылған.
Deviations in brain metabolism are the result of longterm pathological processes, which finally are manifested as symptoms of Parkinson’s or Alzheimer’s diseases or multiple sclerosis and other neuropathologies, as for example diabetic neuropathy. A deficiency of available energy for brain cells under neurodegenerative diseases is either developed due to age-dependent underexpression of genes that encode glycolytic enzymes or induced due to the uncoupling of oxidation and phosphorylation that could be mediated by inflammatory cytokines. Since the activity of many enzymes is under the control of adenosine triphosphate (ATP) or cofactors, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), energy deficiency can cause metabolic changes in brain tissue. Some clinical studies using proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) revealed metabolic changes in brain tissue in patients with neurodegenerative diseases. However, data from different authors are quite contradictory, probably because of the complex genesis of metabolic disorders. In the present study, we tested the hypothesis of multidirectional changes in metabolism under the impact of the oxidation and phosphorylation uncoupler 2,4-dinitrophenol (2,4-DNP) and under the impact of 2-deoxy-Dglucose (2-DG), blocking the access of glucose to the brain cells. 1H NMR spectroscopy showed that 2-DG leads to the predominance of excitatory (glutamine + glutamate) neurotransmitters over inhibitory ones (gamma-aminobutyric acid), and 2,4 DNP causes opposite effects. The biochemical mechanisms of the observed changes require a special study, but it can be noted that the ATP deficiency caused by inhibition of glycolysis and the ATP deficiency caused by the uncouplers are accompanied by differently directed changes in the intensity of the tricarboxylic acid cycle. These changes in the intensity of the Krebs cycle are correlated with differently directed changes in the balance of the exciting and inhibitory neurotransmitters. The obtained results show that 1H NMR spectroscopy can be an effective method of differentiated lifetime assessment of the available energy deficit caused by a general suppression of energy exchange in nerve cells or oxidation and phosphorylation uncoupling.
The extremely low flux of ultra-high energy cosmic rays (UHECR) makes their direct observation by orbital experiments practically impossible. For this reason all current and planned UHECR experiments detect cosmic rays indirectly by observing the extensive air showers (EAS) initiated by cosmic ray particles in the atmosphere. The world largest statistics of the ultra-high energy EAS events is recorded by the networks of surface stations.

In this paper we consider a novel approach for reconstruction of the arrival direction of the primary particle based on the deep convolutional neural network. The latter is using raw time-resolved signals of the set of the adjacent trigger stations as an input. The Telescope Array (TA) Surface Detector (SD) is an array of 507 stations, each containing two layers plastic scintillator with an area of $3$ m$^2$. The training of the model is performed with the Monte-Carlo dataset. The details of the network architecture and its optimization for this particular task are discussed.

It is shown that within the Monte-Carlo simulations, the new approach yields better resolution than the traditional reconstruction method based on the fitting of the EAS front.
Both patients were carriers of CNTN6 gene microdeletion (Kashevarova et al., 2014).

The human induced pluripotent stem cell (iPSC) lines, ICGi009-A, ICGi009-B, ICGi013-A and ICGi013-B, were generated from skin fibroblasts of two siblings with intellectual disability.

iPSC lines have normal karyotype, express pluripotency markers, are able to differentiate in vitro into derivatives of all three germ layers and represent a unique tool to study neurodevelopmental disorders.
On the one hand, the widespread use of electron microprobe analysis in the version of a scanning electron microscope (SEM) equipped with an energy dispersive spectrometer (EDS) and, on the other hand, the comparability of the metrological characteristics of the EDS and wavelength dispersive spectrometry (WDS) in the case of determining the major components of minerals are a favourable background for investigating the possibility of using SEM-EDS for chemical dating of uranium mineralization. Carbonaceous-siliceous formations of the Dabanzhalga suite are widespread in carbonate deposits of the Lower Paleozoic in the Oka structural-formational zone of the East Sayan and represent deep-water deposits of the back-arc basin. All varieties of carbonaceous-siliceous rocks of the Dabanzhalga suite are characterized by increased U, Au, Ag, Pt, Pd, Mo, V, P, Cu. Their amounts are 5–10 times higher than those for other black shale deposits of the Eastern Sayan. Uranium forms its minerals – uraninite and brannerite, in association with carbonaceous matter and sulfides, and is also part of anhydrous phosphates – xenotime, monazite. The paper presents data on the composition and dating of brannerite and uraninite in samples of carbonaceous-siliceous shale sampled at three sites: Uber-Zhadoy, Deed-Khara-Zhalga and Erye-Khara-Zhalga. The obtained estimates of the isochronous dates of uraninite and brannerite grains for these areas are 523±26, 506±10, and 511±17 Ma, respectively. It was shown that these dates could be compared with the age of metamorphism at the Sukhoi Log deposit, estimated using modern methods of isotope geochronology. It should be noted that the average estimates of the dates of uraninite and brannerite in all studied areas of the Dabanzhalga suite are lower than the corresponding estimates of the isochronous date, which is probably due to the partial loss of radiogenic lead. For the Uber-Zhadoy site, a comparison of the EDS and WDS data was carried out, and it was shown that when using the EDS data, there is an underestimation of the Pb content in uraninite, and, as a consequence, an underestimation of the age of uraninite.
Some instances of electron field emitters are characterized by frequency-dependent hysteresis in their current–voltage characteristics. We argue that such emitters can be classified as memristive systems and introduce a general framework to describe their response. As a specific example of our approach, we consider field emission from a carbon nanotube array. Our experimental results demonstrate a low-field hysteresis, which is likely caused by an electrostatic alignment of some of the nanotubes in the applied field. We formulate a memristive model of such phenomena, whose results are in agreement with the experimental results.
Foraminifer is a very useful microorganism to perform biostratigraphical zonation of the Upper Jurassic. Foraminiferal biozones are calibrated by the ammonite standard zones and can be used for intra- and interregional correlations.

Furthermore, the fossil record of foraminiferal faunas is well known among basins of the Northern Eurasia and is also used for accurate palaeoenvironmental, palaeobiogeographical, or biofacial reconstructions. It allows identifying a complex set of biotic and abiotic events which may be used to propose a more general palaeoecoloecological and palaeoceanographical reconstruction of the Subboreal, Boreal, and Arctic seas.

Then, the late Kimmeridgian Northern Eurasian seas formed a network of well-connected palaeobasins during the sea-level rise and resulted in rather similar palaeoenvironmental conditions.
The discovery of extraordinary optical transmission (EOT) through patterned metallic foils in the late 1990s was decisive for the development of plasmonics and cleared the path to employ small apertures for a variety of interesting applications all along the electromagnetic spectrum. However, a typical drawback often found in practical EOT structures is the large size needed to obtain high transmittance peaks. Consequently, practical EOT arrays are usually illuminated using an expanded (mimicking a plane wave) beam. Here, it is shown with numerical and experimental results in the THz range that high transmittance peaks can be obtained even with a reduced illumination spot exciting a small number of holes, provided that the structure has a sufficient number of lateral holes out of the illumination spot. These results shed more light on the prominent role of leaky waves in the underlying physics of EOT and have a direct impact on potential applications.
The purpose of analyzing possible interpretations of the antithesis Sense and Sensibility in the title of J. Austen's novel is to provide a theoretical basis for the author’s broader research. Presented also in other articles, the entire study is devoted to the analysis of different interpretations of the antithesis in French and Russian translations: both in the title and in the main message (macrocontext) of the novel.

As a practical part of the research, the author presents in the current article her own arguments related to possible new interpretations of the antithesis. Namely: 1) hypothesis about a dual nature in the meaning of the antithesis itself: not only the traditional opposition 'reason vs. feelings', but also the sense of objective reality vs. individual’s subjective sensibility; 2) comparison of the moral message of the novel (opposition 'reason vs. feelings' in favor of the merits of reason) and modern theories of emotional intelligence.

The author tries to prove that the four-branch model of emotional intelligence by P. Salovey and J. Mayer is based on the classic message – the merits of reason, however completed with commercial and pragmatic aspects. In addition, this new interpretation of the antithesis (sense of objective reality vs. individual’s subjective sensibility) is complemented by the author with her own possible Russian versions of the novel title, reflecting the new meaning and at the same time preserving the alliteration that the English original has.