Hengzongshu/ArticleAgent huggingface dataset:
Background: Rare Earth Elements (REEs) control methanol utilization in both methane- and methanol-utilizing microbes. It has been established that the addition of REEs leads to the transcriptional repression of MxaFI-MeDH [a two-subunit methanol dehydrogenase (MeDH), calcium-dependent] and the activation of XoxF-MeDH (a one-subunit MeDH, lanthanum-dependent). Both enzymes are pyrroquinoline quinone-dependent alcohol dehydrogenases and show significant homology; however, they display different kinetic properties and substrate specificities. This study investigates the impact of the MxaFI to XoxF switch on the behavior of metabolic networks at a global scale. Results: In this study we investigated the steady-state growth of Methylomicrobium alcaliphilum 20ZR in media containing calcium (Ca) or lanthanum (La, a REE element). We found that cells supplemented with La show a higher growth rate compared to Ca-cultures; however, the efficiency of carbon conversion, estimated as biomass yield, is higher in cells grown with Ca. Three complementary global-omics approaches-RNA-seq transcriptomics, proteomics, and metabolomics-were applied to investigate the mechanisms of improved growth vs. carbon conversion. Cells grown with La showed the transcriptional activation of the xoxF gene, a homolog of the formaldehyde-activating enzyme (fae2), a putative transporter, genes for hemin-transport proteins, and nitrate reductase. In contrast, genes for mxaFI and associated cytochrome (mxaG) expression were downregulated. Proteomic profiling suggested additional adjustments of the metabolic network at the protein level, including carbon assimilation pathways, electron transport systems, and the tricarboxylic acid (TCA) cycle. Discord between gene expression and protein abundance changes points toward the possibility of post-transcriptional control of the related systems including key enzymes of the TCA cycle and a set of electron-transport carriers. Metabolomic data followed proteomics and showed the reduction of the ribulose-monophosphate (RuMP) pathway intermediates and the increase of the TCA cycle metabolites. Conclusion: Cells exposed to REEs display higher rates of growth but have lower carbon conversion efficiency compared to cells supplemented with Ca. The most plausible explanation for these physiological changes is an increased conversion of methanol into formate by XoxF-MeDH, which further stimulates methane oxidation but limits both the supply of reducing power and flux of formaldehyde into the RuMP pathway.
A 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl lithium derivative was found to react with perfluoroaromatic compounds with formation of products of fluoro-atom substitution, namely fluorinated aryl(hetaryl)-substituted nitronyl nitroxides.The yields of the fluorinated nitroxides were acceptable in cases of reactions with functionalized perfluorobenzene and perfluoropyridine (25-60%), but was low in case of reaction with perfluorobiphenyl (~ 5%).Molecular and crystal structures of the obtained nitronyl nitroxides were solved by monocrystal Xray diffraction analysis, and the nature of the radical was ascertained by EPR.
With the development of advanced molecular-genetic and computational technologies it becomes possible to tackle individual cells within a regenerating tissue, to define morphogenetic and cellular changes in space and time by live imaging, to acquire transcriptome status with single-cell RNA sequencing (ScRNA-seq), and to delineate the candidate mechanisms by iterative computational and experimental approaches.

Here, we review recent findings and current knowledge on tissue regeneration in plants, focusing on four evolutionarily conserved scenarios that a cell may embark on to facilitate the regeneration of a plant tissue structure lost by injury, namely cell death, division, dedifferentiation, and transdifferentiation.

Understanding of these scenarios at single-cell resolution, singularly and in combination, could provide an unprecedented view of tissue regeneration in plants.
Herein, we report on a three-component supramolecular hybrid system built from specific recognition processes involving a Dawson-type polyoxometalate (POM), [P2W18O62]6–, a cationic electron-rich cluster [Ta6Br12(H2O)6]2+, and γ-cyclodextrin (γ-CD). Such materials have been investigated using a bottom-up approach by studying the specific interactions between γ-CD and both types of inorganic units. Their ability to interact has been investigated in the solid state by single-crystal X-ray diffraction (XRD) and in solution using multinuclear NMR methods (including DOSY, EXSY, and COSY), electrospray ionization mass and UV–vis spectroscopies, electrochemistry, and isothermal titration calorimetry experiments. Single-crystal XRD analysis reveals that POM:γ-CD constitutes a highly versatile system which gives aggregates with 1:1, 1:2, and 1:3 stoichiometry. Surprisingly, these arrangements exhibit a common feature wherein the γ-CD moiety interacts with the Dawson-type POMs through its primary face. We present also the first structural model involving an octahedral-type metallic cluster with γ-CD. XRD study reveals that the cationic [Ta6Br12(H2O)6]2+ ion is closely embedded within two γ-CD units to give a supramolecular ditopic cation, suitable to be used as a linker within extended structure. Solution study demonstrates clearly that pre-associations exist in solution, for which binding constants and thermodynamic parameters have been determined, giving preliminary arguments about the chaotropic nature of the inorganic ions. Finally, both building blocks, i.e., the ditopic supramolecular cation {[Ta6Br12(H2O)6]@2CD}2+ and the Dawson-type anion, react together to give a three-component, well-ordered hybrid material derived either as a supramolecular hydrogel or single crystals. The solid-state structure shows an unprecedented helicoidal tubular chain resulting from the periodic alternation of POM and supramolecular cation, featuring short hydrogen-bonding contacts between the electron-poor POM and electron-rich cluster. The 1D tubular ionic polymer observed in the single crystals should make it possible to understand the long-range ordering observed within the hydrogel hybrid material. The supramolecular chemical complementarities between the γ-CD-based ditopic cation and POM open a wide scope for the design of hybrid materials that accumulate synergistic functionalities.
The review focuses on describing the specific role of parents in the development of children with autism spectrum disorders (ASD). The main directions of modern research in this field are allocated. Relations of attachment, components of social development in children with ASD and such chsracteristics of parents as sensitivity, responsiveness, insightfulness, synchrony are considered. Features of relationships of parents and childrens emotional regulation, parent emotional co-regulation in children as an important factor of child with ASD development are described. Factors of parental stress and its possible impact on the children development have been analysed. Ideas about the broader phenotype of ASD as a possible cause of some parent features and its impact on children with ASD are given. A conclusion about the promising directions of research in the field under consideration and their practical significance was made.
In present the elasticity and plasticity are absolutely different models of solids, which are not relate to each other. The experimental observations show, that the plasticity arrives and localizes on the surfaces of structures, which contain solid samples. The transition in special state, where a small part of solid volume is in plastic state, while the main part of volume is in elastic state not be describe by classical continuum Cauchy and Poisson model. This classical model requires two alternative states. Either is elastic state in the all volume or plastic one for all elementary volume too. However, the structured model of space gives us a possibility to describe this complicate state. In this paper shown that the sliding surfaces divided to each other by distances equal to the average sizes of microstructures, in the contrary of classical plasticity, where they have not characteristic distance. The energy of plastic transition is very small, because the main part of volume is elastic body. This description means the smooth transition from elasticity to plasticity in vicinity of sliding surfaces.
The work describes a new developed cell, which allows simultaneous acoustic measurements and X-ray tomography of hydrate-bearing samples. The results of the first experiments on the formation of xenon hydrate in a sand sample by the “excess gas” method are presented. The formation of gas hydrate in the sample led to compressional wave velocity increase associated with cementation of granules with hydrate. The obtained tomographic images showed that formed xenon hydrate envelops sand granules. A uniform distribution of hydrate in the pore space in the scan area is also observed.
The first abnormally coordinated NHC complex of an early transition metal, [(aIMes)TaCl2(NMe2)3], is prepared.
The article discusses the problem of using cognitive visceral cardiobiofeedback as a preventive and non-drug method for correcting disturbed regulation mechanisms associated with an increase in blood pressure in adolescents with essential hypertension (EH) against the background of standard antihypertensive therapy with enalapril.

Each participant underwent a 5-minute CIG recording using the hardware and software complex VedaPulse under physiological rest and during biofeedback session. In the course of biofeedback, the subject was asked to lengthen the expiration phase of the respiratory cycle with parallel relaxation of muscle tone and visual feedback on the dynamics of a multimedia plot reflecting changes in the duration of the cardiac cycle.

We assume that the test with cognitive visceral cardiobiofeedback can serve as an effective marker for the analysis of the rigidity of autonomic mechanisms of regulation in adolescents with essential hypertension. Conscious regulation of the heart rate through the mechanism of controlled respiration (biofeedback) can be an effective non-drug method for correcting autonomic regulation disorders in adolescents with arterial hypertension, which is manifested by a significant decrease in blood pressure.
passively mode-locked fiber master oscillator in different regimes including conventional (stable) and double-scale (partially coherent and noise-like) ones

numerical simulation and experimental observation of second-harmonic generation as an example of non-linear frequency conversion of pulses

non-linear frequency conversion efficiency of double-scale pulses is slightly higher than that of conventional picosecond laser pulses with the same energy and duration despite strong phase fluctuations of double-scale pulses
The adaptive benefits of individual specialization and how learning abilities correlate with task performance are still far from being well-understood. Red wood ants are characterised by their huge colonies and deep professional specialization.

We hypothesized that red wood ants Formica aquilonia form aversive learning after having negative encounters with hoverfly larvae differently, depending on their task specialization. We tested this hypothesis, first, by examining whether hunters and aphid milkers learn differently to avoid the nuisance of contacts with syrphid larvae, and, second, by analysing the difference between learning in 'field' and laboratory-reared (naïve) foragers.

These data provide some new insights into the relationship between task specialization and learning performance in ants. Given our previous results, we speculate that scouts and aphid milkers are the most cognitively gifted specialists in red wood ants, whereas hunters and guards are rather brave than smart.
The efficiency of temperature end energy separation is compared for Ranque tubes of circular and square cross section, with the square side equal to the circle diameter. The “square” tube demonstrates approximately two times less efficiency, yet the separation effect still being evidently presented.
Topological insulators (TIs) represent a new quantum state of matter which is characterized by edge or surface states and an insulating band gap in the bulk. In a two-dimensional (2D) system based on the HgTe quantum well (QW) of critical width random deviations of the well width from its average value result in local crossovers from zero gap 2D Dirac fermion system to either the 2D TI or the ordinary insulator, forming a complicated in-plane network of helical channels along the zero-gap lines. We have studied experimentally the transport properties of the critical width HgTe QWs near the Dirac point, where the conductance is determined by a percolation along the zero-gap lines. The experimental results confirm the presence of percolating conducting channels of a finite width. Our work establishes the critical width HgTe QW as a promising platform for the study of the interplay between topology and localization.
We report on the far-infrared magnetospectroscopy of HgTe quantum wells with inverted band ordering at different electron concentrations. We particularly focus on optical transitions from zero-mode Landau levels, which split from the edges of electron-like and hole-like bands. We observe a pronounced dependence of the transition energies on the electron concentration varied by persistent photoconductivity effect. This is striking evidence that in addition to the already well-documented crystalline and interface asymmetries, electron-electron interactions also have a significant impact on the usual behavior of the optical transitions from zero mode Landau levels.
The number Ka= N / N 1 is used to evaluate the thermal power of a plume; N is the thermal power transferred from the plume base to its conduit, and N 1 is the thermal power transferred from the plume conduit into the surrounding mantle. At the relative thermal power 1.9<Ka<10, after eruption of the melt from the plume conduit to the surface, melting occurs in the crustal block above the plume roof, resulting in the formation of a mushroom-shaped head of the plume. A thermochemical plume originates at the core-mantle boundary and ascends (melts up) to the surface. Based on laboratory and theoretical modeling data, we present the flow structure of melt in the conduit and the head of the thermochemical plume. The features of melting in the plume conduit are elucidated on the basis of the phase diagram of the CaO-MgO-Al 2 O 3 -SiO 2 model system. The two upper convection cells of the plume conduit relate to the region of basic and ultrabasic compositions. Our study shows that melting in these cells proceeds according to monovariant equilibria of eutectic type L=Cpx+Opx+An+Sp and L=Fo+An+Cpx+Opx. In case of the CaO–MgO–Al 2 O 3 –SiO 2 –Na 2 O system, crystallization differentiation proceeds as separation of plagioclase crystals. Separation of plagioclase crystals enriched in anorthite component leads to enrichment of the residual melt in silica and alkaline components. Assuming the initial basaltic melt, we calculated the compositional changes in the melt, which are powered by the heat and mass transfer processes in the mushroom-shaped plume head. The calculations were performed in two stages: (1) after settling of refractory minerals; (2) after settling of plagioclase in the melt resulting from the first stage. In the second stage, the melt contains 88.5 % of plagioclase component. The calculations were performed for melt temperature T melt =1410 °C and pressure P =2.6 kbar and 6.3 kbar. The calculated weight contents of oxides, the normative compositions for solid phase, and the oxide content and normative composition for the residual melt were tabulated. The SiO 2 content in the residual melt amounts to 59.6–62.3 % and corresponds to the crustal SiO 2 content.
The reviewed monograph, published by I.V. Kurukin, presents the author's concept of the political history of Russia in the 18 th century, specifically, the period that was called in historiography "the epoch of palace coups" (1725-1762).

The author, using extensive source and bibliographic base, reconstructs in detail the military and political mechanisms, used every time the reigning monarchs replaced each other on the Russian throne during this period. Along with this, I.V. Kurukin analyzes the dynamics of the personnel composition of the bureaucracy in central state institutions and identifies the principles used by the supreme power for appointments and resignations after each new coup.

I.V. Kurukin shows that in 1725-1741 the role of the military factor (Royal guard units) in these events increased, and over time the focus of activity shifted from the highest ranks to officers and even soldiers. In the 2 nd half of the 18 th century another trend can be traced, in which the key characteristics were an appropriate level of conspiracy in the organization of a political plot and the control of its leaders over the activities of officers and soldiers. The reviewed monograph makes a significant contribution to the study of problems of political history of 18 th century Russia, identifying features of the evolution and functioning of military and civil administration in the system of imperial governing institutions.
The paper presents data on the effect of a distributed roughness of the blunted nose of the cone on the position of the laminar-turbulent transition. The studies were carried out at Mach number 5.95. It is found that the position of the roughness plays an important role in the transition process, it is obtained that the roughness has the greatest effect on the transition when applied to an angle Θ ≈ 90 °. It was found that the presence of a roughness on the nose of the model, even at subcritical Reynolds numbers, affects the pulsation processes in the boundary layer.
The temporal evolution of quantal Joule heating of 2D electrons in GaAs quantum well placed in quantizing magnetic fields is studied

using a difference frequency method. The method is based on measurements of the electron conductivity oscillating at the beat frequency $f=f_1-f_2$ between two microwaves applied to 2D system at frequencies $f_1$ and $f_2$. The method provides $direct$ access to the dynamical characteristics of the heating and yields the inelastic scattering time $	au_{in}$ of 2D electrons.

The obtained $	au_{in}$ is strongly temperature dependent, varying from 0.13 ns at 5.5K to 1 ns at 2.4K in magnetic field $B$=0.333T. When temperature $T$ exceeds the Landau level separation the relaxation rate $1/	au_{in}$ is proportional to $T^2$, indicating the electron-electron interaction as the dominant mechanism limiting the quantal heating. At lower temperatures the rate tends to be proportional to $T^3$, indicating considerable contribution from electron-phonon scattering.
Aim . To investigate polymorphisms of 18 genes as possible molecular genetic markers of predisposition or resistance to development of non-infective (NE) or infective endocarditis (IE).

Materials and methods . The study encompassed 81 patients with NE and 94 patients with IE. The control group included 225 conditionally healthy people. Polymorphisms of 18 genes were tested using polymerase chain reaction (PCR).

Results . For the first time, a statistically significant relationship was identified between gene polymorphisms and valvular vegetations: for genes in the hemostatic system – rs6025 (1691 G > A) of the F5 gene (AG genotype), rs1126643 (807 C > T) of the ITGA2 gene (TT genotype); for folate pathway genes – rs1805087 (2756 A > G) of the MTR gene (AG genotype) and rs11697325 (–8202 A/G) of the MMP9 gene (AA genotype) and rs2476601 (C1858T) of the PTPN22 gene (TT genotype). The protective effect of gene polymorphisms was revealed: for the NOS3 gene (4b / 4b genotype) and G (–572) C of the IL6 gene (CC genotype). For two polymorphisms, an association with thromboembolic complications in NE was revealed: rs1126643 (807 C > T) of the ITGA2 gene and rs1799889 (–675 5G > 4G) of the PAI (SERPINE1) gene. In IE, such an association was detected for the polymorphism rs11697325 (–8202 A/G) of the MMP- 9 gene. Conclusion . The polymorphisms of candidate genes were revealed, that are associated with the clinical and hemostasiological characteristics of IE and NE. In NE, for the first time, the association with thromboembolic complications was identified for two polymorphisms: rs1126643 (807 C > T) of the ITGA2 gene and rs1799889 (– 675 5G > 4G) of the PAI-1 (SERPINE1) gene. In IE, such a relationship was detected for one polymorphism – rs11697325 (8202 A/G) of the MMP-9 gene.
In the paper, the authors describe some results of a numerical simulation of the air flow around a bluff body mounted on a flat plate taking into account the injection of a tracer gas through a hole located in the substrate behind the body. The aim of this paper is to describe flow structure in the vicinity of a prism taking into account unstable stratification of the boundary layer which is characterized by a negative vertical temperature gradient. The results of numerical simulation for an unstable thermal state were compared with those obtained for the case of stable stratification for the same geometry configuration.
In this study, the active and stable cross-linked enzyme aggregates (CLEAs) of the thermostable esterase estUT1 of the bacterium Ureibacillus thermosphaericus were prepared for application in malathion removal from municipal wastewater. Co-expression of esterase with an E. coli chaperone team (KJE, ClpB, and ELS) increased the activity of the soluble enzyme fraction up to 200.7 ± 15.5 U mg−1. Response surface methodology (RSM) was used to optimize the preparation of the CLEA-estUT1 biocatalyst to maximize its activity and minimize enzyme loss. CLEA-estUT1 with the highest activity of 29.4 ± 0.5 U mg−1 (90.6 ± 2.7% of the recovered activity) was prepared with 65.1% (w/v) ammonium sulfate, 120.6 mM glutaraldehyde, and 0.2 mM bovine serum albumin at 5.1 h of cross-linking. The biocatalyst has maximal activity at 80 °С and pH 8.0. Analysis of the properties of CLEA-estUT1 and free enzyme at 50–80 °C and pH 5.0–10.0 showed higher stability of the biocatalyst. CLEA-estUT1 showed marked tolerance against a number of chemicals and high operational stability and activity in the reaction of malathion hydrolysis in wastewater (up to 99.5 ± 1.4%). After 25 cycles of malathion hydrolysis at 37 °С, it retained 55.2 ± 1.1% of the initial activity. The high stability and reusability of CLEA-estUT1 make it applicable for the degradation of insecticides.
The article notes the need for the transition of the resource sector of the Russian economy to an innovative development path and shows the potential for this.

Some results of constructing a scenario forecast of the Russian economy development using the expert-statistical Bayesian method are presented. The peculiarity of the method: it is based on expert estimates and allows you to make forecasts in conditions of severe uncertainty.

A predictive assessment of the resource sector impact on innovation in Russia in the period until 2030-2035 was made in the framework of the study. According to experts, the existing potential will not be fully utilized. Insufficient participation of the resource sector in the national innovation process is projected; attraction to import is the most likely. This reflects the general trend of the forecasted scientific and technological development of a country with a 'sluggish' innovation market: insufficient supply, insufficient demand and the weak mechanism of the relationship between the first and second.