Hengzongshu/ArticleAgent huggingface dataset:
A robust and solvent-free mechanochemical approach for the synthesis of cobalt–nitrogen–carbon nanocomposite by simple mixing of cobalt(II) salts, nitrogen-containing ligands and carbon black, followed by thermal treatment is suggested. The catalysts obtained were tested in the oxidative esterification of benzyl alcohol, demonstrating highly competitive performance.
The process e+e−→γχcJ (J=1, 2) is studied via initial state radiation using 980 fb−1 of data at and around the Υ(nS) (n=1, 2, 3, 4, 5) resonances collected with the Belle detector at the KEKB asymmetric-energy e+e− collider.

No significant signal is observed except from ψ(2S) decays. Upper limits on the cross sections between √s=3.80 and 5.56 GeV are determined at the 90% credibility level, which range from a few pb to a few tens of pb.

We also set upper limits on the decay rate of the vector charmonium [ψ(4040), ψ(4160), and ψ(4415)] and charmoniumlike [Y(4260), Y(4360), and Y(4660)] states to γχcJ.
On the basis of a comprehensive analysis of geological and geophysical materials, seismogeological models of sedimentary complexes in the South Kara oil-and-gas province (OGP) and in the North Kara potential oil-and-gas province (POGP) were constructed. The conclusion is drawn that the South-Kara OGA is the northern end of the West Siberian oil-and-gas province and the Jurassic and Cretaceous deposits are of the greatest interest here. North-Kara POGP is the continuation of the Barents Sea province and Triassic and Jurassic rocks have the biggest petroleum potential. On most of the POGP, the main prospects of oil production are associated with the Neoproterozoic-Paleozoic sedimentary complex.
Cell migration is an important morphogenetic process necessary at different stages of individual development and body functioning. The initiation and maintenance of the cell movement state requires the activation of many factors involved in the regulation of transcription, signal transduction, adhesive interactions, modulation of membranes and the cytoskeleton. However, cell movement depends on the status of both migrating and surrounding cells, interacting with each other during movement. The surrounding cells or cell matrix not only form a substrate for movement, but can also participate in the spatio-temporal regulation of the migration. At present, there is no exact understanding of the genetic mechanisms of this regulation.

To determine the role of the cell environment in the regulation of individual cell migration, we studied the migration of primordial germline cells (PGC) during early embryogenesis in Drosophila melanogaster. Normally, PGC are formed at the 3rd stage of embryogenesis at the posterior pole of the embryo. During gastrulation (stages 6–7), PGC as a consolidated cell group passively transfers into the midgut primordium. Further, PGC are individualized, acquire an amoeboid form, and actively move through the midgut epithelium and migrate to the 5–6 abdominal segment of the embryo, where they form paired embryonic gonads. We screened for genes expressed in the epithelium surrounding PGC during early embryogenesis and affecting their migration. We identified the myc, Hph, stat92E, Tre-1, and hop genes, whose RNA interference leads to premature active PGC migration at stages 4–7 of embryogenesis.

These genes can be divided into two groups: 1) modulators of JAK/STAT pathway activity inducing PGC migration (stat92E, Tre-1, hop), and 2) myc and Hph involved in epithelial morphogenesis and polarization, i.e. modifying the permeability of the epithelial barrier. Since a depletion of each of these gene products resulted in premature PGC migration, we can conclude that, normally, the somatic environment negatively regulates PGC migration during early Drosophila embryogenesis.
Настоящая работа продолжает исследования принципов больших уклонений обобщенных процессов восстановления, начатые в [1], [2]. Основным объектом изучения являются вероятности больших уклонений траекторий обобщенных процессов восстановления. Работа состоит из двух частей. В части I при некотором условии на распределение процесса получен так называемый первый частичный локальный принцип больших уклонений для траекторий обобщенного процесса восстановления. В части II при альтернативном условии получен второй частичный локальный принцип больших уклонений. При дополнительных условиях получены также "полный локальный" и "полный интегральный" принципы больших уклонений для обобщенных процессов восстановления.
The multitude of existing methods for assessing the phenotypic stability of plants makes breeders be faced with the problem of choosing an appropriate variant.

The purpose of this study was to compare different methods of analyzing the genotype x environment interaction and, on their basis, assess the stability of the yield of 7 varieties of winter wheat. The article compares 17 stability statistics by applying them to data obtained from agrotechnical experiments carried in 2009-2011 for evaluating the grain yield of 7 varieties of winter common wheat of Siberian selection (Novosibirskaya 32, Novosibirskaya 40, Novosibirskaya 51, Novosibirskaya 3, Novosibirskaya 2, Obskaya winter, Omskaya 6). Analysis of variance revealed a significant (p < 0.001) genotype x environment interaction in the experiments, which indicates a different reaction of genotypes to changes in environmental conditions. Genotypes were ranked according to the level of stability. Based on the analysis of the rank correlation matrix, the stability statistics were categorized in five groups.

Recommendations were made on which group of methods to use depending on the objectives of the study. In the case when the goal of breeding research is the selection of the most biologically stable varieties with the minimum variance across a range of environments, one should use the methods of the static concept. If it is necessary to choose a genotype with a predictable reaction to changes of environmental conditions, corresponding to the calculated level or forecast, the regression approach is the most appropriate. The stability statistics generally identified Novosibirskaya 32 as the most stable variety from a biological point of view. The regression approach showed that Novosibirskaya 3 was the genotype with the smallest deviation from mean yield in all environments, while methods accessing the contribution of each genotype to the genotype x environment interaction defined Novosibirskaya 51 as the most stable variety.
Protocyanin is a complex pigment extracted from flower petals of blue cornflower, Centaurea cyanus.The components of protocyanin were recently demonstrated to be anthocyanin (AN), flavone glycoside (FL), Fe 3+ , Mg 2+ and Ca 2+ ions [1] .

For X-ray structure determination, protocyanin was reconstructed from the components and crystallized in space group P2 1 2 1 2 1 with unit cell dimensions of a = 29.7,b = 49.2 and c = 78.3Å.Two protocyanin molecules are contained in an asymmetric unit.Data were collected on the beam line 6A at Photon Factory KEK to1.05 Å resolution.

The refined molecule has pseudo three-fold symmetry and four metals align along the pseudo three-fold axis in order of Ca 2+ , Fe 3+ , Mg 2+ and Ca 2+ .The four metals are coordinated to six AN and six FL molecules.The inner Fe 3+ and Mg 2+ ions are each coordinated to three AN's, respectively, while the outer two Ca 2+ ions are each coordinated to three FL's.Both AN and FL molecules are self-associated with each other as AN-AN and FL-FL in pair and this hydrophobic association also exists between AN and FL molecules, building copigmentation stacks.Protocyanin is a tetra-metal (Fe 3+ , Mg 2+ , 2Ca 2+ ) nuclear complex, a new type of supramolecular pigment.
В статье анализируется трансформация образа благополучного будущего от «советского поколения» к поколению «Z». Актуальность исследования обусловлена необходимостью понимания специфики формирования оценки состояния благополучия и ее связи с мотивацией и активностью современного поколения.

Целью данного исследования является разработка и апробация методологического инструментария исследования проблемы благополучия. Методы исследования: базисным основанием исследования является методология междисциплинарного синтеза. На основе теорий К. Альдерфера и К. Герцберга трактуется связь изменения базовой мотивации общества с изменением базисных элементов образа будущего. Описание модели «трансформирующей призмы» позволяет определить причины противоречий в научных исследованиях при оценке картины благополучия. На основе исторического метода исследуется образ коммунизма и его значение в оценке благополучия людьми, принадлежащих к «советскому поколению». При помощи социологического опроса выявляются ключевые компоненты образа будущего поколения «Z». Сравнительный анализ позволяет оценить корректность применения модели «трансформирующей призмы» для понимания причин отдельных элементов желаемой модели благополучия.

Результаты: использование методологии междисциплинарного синтеза позволяет существенно расширить горизонты научного познания. Применение модели «трансформирующей призмы» позволяет сделать более точные и корректные выводы относительно природы постоянных и переменных элементов в образе благополучия исследуемого поколения.
We report transport measurements in HgTe-based quantum wells with well width of 8 nm, corresponding to the quantum spin Hall state, subject to in-plane magnetic field. In the absence of the magnetic field the local and nonlocal resistances behave very similarly, which confirms the edge state transport in our system. In the magnetic field, we observe a monotonic decrease of the resistance with saturation of local resistance, while nonlocal resistance disappears completely, independent of the gate voltage. We believe that this evidence of metallic behavior indicates a transition to a gapless two-dimensional phase, according to theoretical predictions. The influence of disorder on resistivity properties of HgTe quantum wells under in-plane magnetic field is discussed.
One of remarkable properties of QCD is the gluon Reggeization. The Reggeized gluon is the primary Reggeon in QCD; Pomeron and Odderon appear as compound states of the Reggeized gluons. Due to negative signature the Reggeized gluon gives the main contributions to high energy QCD amplitudes in each order ofperturbation theory. In the leading and next-to-leading logarithmic approximations these amplitudes aregiven by the Regge pole contributions. In the next-to-next-to-leading approximation the pole form of the amplitudes is violated by contributions of three-Reggeon cuts. We discuss these contributions to elastic QCD amplitudes.
B chromosomes (Bs) were described in most taxa of eukaryotes and in around 11.9% of studied Orthopteran species. In some grasshopper species, their evolution has led to many B chromosome morphotypes.

We studied the Bs in nine species (Nocaracris tardus, Nocaracris cyanipes, Aeropus sibiricus, Chorthippus jacobsoni, Chorthippus apricarius, Bryodema gebleri, Asiotmethis heptapotamicus songoricus, Podisma sapporensis, and Eyprepocnemis plorans), analyzing their possible origin and further development. The studied Bs consisted of C-positive or C-positive and C-negative regions. Analyzing new data and considering current hypotheses... The hypothesis is based on the findings of the Eyprepocnemis plorans specimens with autosome containing numerous intercalary repeat clusters, analysis of C-positive Bs in Eyprepocnemis plorans and Podisma sapporensis containing intercalary and terminal C-negative regions, and development of heterochromatic neo-Y chromosome in some Pamphagidae grasshoppers.

We suggest that Bs in grasshoppers could arise through different mechanisms and from different chromosomes of the main set. We gave our special attention to the Bs with C-negative regions and suggest a new hypothesis of B chromosome formation from large or medium autosomes. This hypothesis includes dissemination of repetitive sequences and development of intercalary heterochromatic blocks in euchromatic chromosome arm followed by deletion of euchromatic regions located between them.
The article notes the need for the transition of the resource sector of the Russian economy to an innovative development path and shows the potential for this. Some results of constructing a scenario forecast of the Russian economy development using the expert-statistical Bayesian method are presented. The peculiarity of the method: it is based on expert estimates and allows you to make forecasts in conditions of severe uncertainty. A predictive assessment of the resource sector impact on innovation in Russia in the period until 2030-2035 was made in the framework of the study. According to experts, the existing potential will not be fully utilized. Insufficient participation of the resource sector in the national innovation process is projected; attraction to import is the most likely. This reflects the general trend of the forecasted scientific and technological development of a country with a “sluggish” innovation market: insufficient supply, insufficient demand and the weak mechanism of the relationship between the first and second.
Least squares collocation method (LSC) is a versatile numerical method for solving boundary value problems for PDE.

The present article demonstrates the abilities of LSC to solve various problems – in particular, calculations of bending of isotropic irregular shaped plates and multi-layered anisotropic plates. In order to achieve higher accuracy, new versions of the method utilize high-degree polynomial spaces.

The numerical experiments demonstrate high accuracy of the solutions.
Because DNase antibodies are cytotoxic, enter the nucleus and cause DNA fragmentation inducing cell death by apoptosis, they can play an important role in the pathogenesis of different autoimmune pathologies and especially systemic lupus erythematosus (SLE). The interesting goal of catalytic antibodies research is not only to study a possible biological role of such antibodies, but also to develop in future new human and animal therapies that use the advantages offered by abzymes.

An immunoglobulin κ light chain library from SLE patients was cloned into a phagemid vector. Phage particles displaying recombinant monoclonal antibody light chains (MLChs) capable of binding DNA were isolated by affinity chromatography on DNA-cellulose. Sixteen of the 46 MLChs efficiently hydrolyzed DNA; one MLCh (approximately 27–28kDa) was expressed in Escherichia coli and purified by metal chelating and gel filtration. MLCh NGK-1 was electrophoretically homogeneous and demonstrated a positive answer with mouse IgGs against light chains of human antibodies after western blotting. SDS-PAGE in a gel containing DNA demonstrated that the MLCh hydrolyzes DNA and is not contaminated by canonical DNases.

The DNase MLCh was activated by several metal ions. The protein sequence of the DNase MLCh has homology with mammalian DNases I and shares with them several identical or similar (with the same side chain functionality) important amino acid residues, which are necessary for DNA hydrolysis and binding of Mg2+ and Ca2+ ions. The affinity of DNA for this first example of a MLCh (KM = 0.3 microM) was 150- to 200-fold higher than for human DNase I.
В течение нескольких лет российско-кыргызскими учеными активно изучалось местонахождение Обишир-V, которое находится в Кыргызстане.Археологами было установлено, что Ферганская долина и окружающие ее территории активно заселялись людьми в раннем голоцене, о чем свидетельствует большое число археологических памятников этого времени.Они предполагают, что этот процесс был связан с благоприятными климатическими условиями, главными факторами которых являются потепление и/или повышение влажности.В работе представлены палеоэкологические результаты изучения наземных моллюсков, найденных в отложениях верхнего неоплейстоценанижнегосреднего голоцена местонахождения Обишир-V.Таксономический анализ состава малакофауны позволил сделать палеоэкологические выводы относительно предпочтений моллюсков по отношению к температуре, влажности, растительности и особенностям их среды обитания (биотопов).Было установлено, что палеоландшафты и растительность в период накопления изученных отложений остались практически без изменений.Моллюски обитали среди степной растительности в условиях сухого и теплого климата, но присутствовали и небольшие временные интервалы с повышенной влажностью.
The most popular model for the search of ChIP-seq data for transcription factor binding sites (TFBS) is the positional weight matrix (PWM). However, this model does not take into account dependencies between nucleotide occurrences in different site positions. Currently, two recently proposed models, BaMM and InMoDe, can do as much. However, application of these models was usually limited only to comparing their recognition accuracies with that of PWMs, while none of the analyses of the co-prediction and relative positioning of hits of different models in peaks has yet been performed. To close this gap, we propose the pipeline called MultiDeNA. This pipeline includes stages of model training, assessing their recognition accuracy, scanning ChIP-seq peaks and their classif ication based on scan results. We applied our pipeline to 22 ChIP-seq datasets of TF FOXA2 and considered PWM, dinucleotide PWM (diPWM), BaMM and InMoDe models. The combination of these four models allowed a signif icant increase in the fraction of recognized peaks compared to that for the sole PWM model: the increase was 26.3 %. The BaMM model provided the main contribution to the recognition of sites. Although the major fraction of predicted peaks contained TFBS of different models with coincided positions, the medians of the fraction of peaks containing the predictions of sole models were 1.08, 0.49, 4.15 and 1.73 % for PWM, diPWM, BaMM and InMoDe, respectively. Thus, FOXA2 BSs were not fully described by only a sole model, which indicates theirs heterogeneity. We assume that the BaMM model is the most successful in describing the structure of the FOXA2 BS in ChIP-seq datasets under study.
Although the cyclo-P6 complex [(Cp*Mo)2 (μ,η(6) :η(6) -P6 )] (1) was reported 30 years ago, little is known about its chemistry. Herein, we report a high-yielding synthesis of 1, the complex 2, which contains an unprecedented cyclo-P10 ligand, and the reactivity of 1 towards the "naked" cations Cu(+) , Ag(+) , and Tl(+) . Besides the formation of the single oxidation products 3 a,b which have a bisallylic distorted cyclo-P6 middle deck, the [M(1)2 ](+) complexes are described which show distorted square-planar (M=Cu(4 a), Ag(4 b)) or distorted tetrahedral coordinated (M=Cu(5)) M(+) cations. The choice of solvent enabled control over the reaction outcome for Cu(+) , as proved by powder XRD and supported by DFT calculations. The reaction with Tl(+) affords a layered two-dimensional coordination network in the solid state.
This process is sensitive to the proton unintegrated gluon distribution at small x and to the proton light-cone distribution amplitudes.

We consider the exclusive diffractive dissociation of a proton into three jets with large transverse momenta in the double-logarithmic approximation of perturbative QCD.

According to our estimates, an observation of such processes in the early runs at LHC is feasible for jet transverse momenta of the order of 5 GeV.
Enzymatic oxidation of L-arginine catalyzed by inducible nitric oxide synthase gives nitric oxide as the main product and superoxide anion as a side reaction product. Recombination of these radicals gives a very reactive species – peroxynitrite, which is involved in many biochemical processes. In the current work it was shown that such a system can be a usable model system for investigating the influence of magnetic field on enzymatic peroxynitrite formation. Using a selective fluorescent probe for peroxynitrite - coumarin boronic acid and an adopted for the experimental purpose incubation mixture, magnetic field experiments have been done at 11.7T. The averaged magnetic field effect is equal to 2.8±0.9%.
Adolescence and youth are sensitive periods in terms of the formation of a moral and value orientation that performs a regulatory function and defines sustainable value preferences and life principles that characterize a person’s life choices.

In this article, from the position of the age-psychological approach, the results of the study of the moral and value sphere in groups of adolescents and young people are presented.

A comparative analysis of the levels of development of moral judgments, personal autonomy and value orientations of adolescents and young people revealed the differences in the selected groups.
In this work, the method of lattice Boltzmann equations was applied to simulate the systems of two and three parallel laminar plane jets. Simulation was carried out for different Reynolds numbers (Re = 20-200). For the case of two jets, the character of jet interaction has been determined to be, in general, non-stationary, but for small Re values, the process becomes stable due to the action of viscosity forces. For the case of three jets, the character of jets interaction is found to differ significantly from the case of two jets and is non-stationary even for small Re numbers.
NTRK gene fusions are drivers of tumorigenesis events that specific Trk-inhibitors can target. Current knowledge of the downstream pathways activated has been previously limited to the pathways of regulator proteins phosphorylated directly by Trk receptors. Here, we aimed to detect genes whose expression is increased in response to the activation of these pathways. We identified and analyzed differentially expressed genes in thyroid cancer samples with NTRK1 or NTRK3 gene fusions, and without any NTRK fusions, versus normal thyroid gland tissues, using data from the Cancer Genome Atlas, the DESeq2 tool, and the Genome Enhancer and geneXplain platforms. Searching for the genes activated only in samples with an NTRK fusion as opposed to those without NTRK fusions, we identified 29 genes involved in nervous system development, including AUTS2, DTNA, ERBB4, FLRT2, FLRT3, RPH3A, and SCN4A. We found that genes regulating the expression of the upregulated genes (i.e., upstream regulators) were enriched in the “signaling by ERBB4” pathway. ERBB4 was also one of three genes encoding master regulators whose expression was increased only in samples with an NTRK fusion. Moreover, the algorithm searching for positive feedback loops for gene promoters and transcription factors (a so-called “walking pathways” algorithm) identified the ErbB4 protein as the key master regulator. ERBB4 upregulation (p-value = 0.004) was confirmed in an independent sample of ETV6-NTRK3-positive FFPE specimens. Thus, ErbB4 is the potential key regulator of the pathways activated by NTRK gene fusions in thyroid cancer. These results are preliminary and require additional biochemical validation.
We revisit cosmic microwave background (CMB) constraints on the abundance of millicharged particles based on the Planck data. The stringent limit Omega_{mcp}h^2 < 0.001 (95% CL) may be set using the CMB data alone if millicharged particles participate in the acoustic oscillations of baryon-photon plasma at the recombination epoch. The latter condition is valid for a wide region of charges and masses of the particles. Adding the millicharged component to LCDM shifts prefered scalar spectral index of primordial perturbations to somewhat larger values as compared to minimal model, even approaching Harrison-Zeldovich spectrum under some assumptions.
Triarylmethanols – the direct precursors of persistent trityl radicals – are racemic mixtures of chiral three‐bladed molecular propellers. Depending on the bulkiness of the aryl groups, they exhibit various tendencies to interconvert, and the half‐life of room‐temperature racemization varies between 8.4 h and 1.32 years. NOESY/EXSY experiments performed on two representative models strongly support the two‐ring flip mechanism for the configurational interchange.