Hengzongshu/ArticleAgent huggingface dataset:
Self-appraisal is a process that leads to the formation of self-esteem, which contributes to subjective well-being and mental health. Neuroimaging studies link self-esteem with the activity of the medial prefrontal cortex (MPFC), right temporoparietal junction (rTPJ), posterior cingulate cortex (PCC), anterior insula (AIns), and dorsolateral prefrontal cortex. It is not known, however, how the process of self-appraisal itself is mediated by the brain and how different nodes of the self-appraisal network interact with each other. In this study, we used multilevel mediation analysis of functional MRI data recorded during the trait adjective judgment task, treating the emotional valence of adjectives as the predictor, behavioral response as the dependent variable, and brain activity as the mediator. The mediation effect was revealed in the rTPJ. Dynamic causal modeling showed that positive self-descriptions trigger communication within the network, with the rTPJ exerting the strongest excitatory output and MPFC receiving the strongest excitatory input. rAIns receives the strongest inhibitory input and sends exclusively inhibitory connections to other regions pointing out to its role in the processing of negative self-descriptions. Analysis of individual differences showed that in some individuals, self-appraisal is mostly driven by the endorsement of positive self-descriptions and is accompanied by increased activation and communication between rTPJ, MPFC, and PCC. In others, self-appraisal is driven by the rejection of negative self-descriptions and is accompanied by increased activation of rAIns and inhibition of PCC and MPFC. Membership of these groups was predicted by different personality variables. This evidence uncovers different mechanisms of positive self-bias, which may contribute to different facets of self-esteem and are associated with different personality profiles.
This article presents the results of the genesis investigation of Ni-and Mo-based dispersed steamcracking catalyst produced via in-situ heavy oil emulsion decomposition.

The structural characteristics of catalysts and their precursors have been studied by SAXS and TEM for the first time at all stages of production and operation: in reverse emulsions, dispersions and in the coke residues obtained after catalytic steam cracking process

It is shown that the Ni-based precursor is converted to larger aggregates during transition from a dispersion in heavy oil to Ni 9 S 8 10-40 nm particles in the coke residue.In the case of molybdenum this trend was not revealed, after steam cracking process two types of particles are formed: small layered MoS 2 particles with a length of 10-15 nm and larger MoO 2 20-30 nm particles.
Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear.

Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based studies: Know Your Heart (KYH) (Russia, 2015–2018, n=4121) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2016, n=17 649). Diabetes was defined by the level of glycated hemoglobin and/or self-reported diabetes and/or diabetes medication use. Marginal structural models were used to estimate the role of key risk factors for diabetes in differences between the studies.

Adiposity is a key modifiable risk factor that appears to explain half of the almost threefold higher female prevalence of diabetes in Russia compared with Norway, but none of the twofold male difference.
Schizophrenia is known to be accompanied not only with an imbalance in the neurotransmitter systems but also with immune system dysregulation and chronic low-grade inflammation. Extracellular histones and nucleosomes as damage-associated molecular patterns (DAMPs) trigger systemic inflammatory and toxic reactions by activating Toll-like receptors. In this work, we obtained the first evidence that polyclonal IgGs of patients with schizophrenia effectively hydrolyze five histones (H1, H2a, H2b, H3, and H4). Several strict criteria were used to demonstrate that histone-hydrolyzing activity is a property of the analyzed IgGs. The IgGs histone-hydrolyzing activity level, depending on the type of histone (H1–H4), was statistically significantly 6.1–20.2 times higher than that of conditionally healthy donors. The investigated biochemical properties (pH and metal ion dependences, kinetic characteristics) of these natural catalytic IgGs differed markedly from canonical proteases. It was previously established that the generation of natural catalytic antibodies is an early and clear sign of impaired humoral immunity. One cannot, however, exclude that histone-hydrolyzing antibodies may play a positive role in schizophrenia pathogenesis because histone removal from circulation or the inflamed area minimizes the inflammatory responses. Thus, it can be assumed that histone-hydrolyzing antibodies are a link between humoral immunity and inflammatory responses in schizophrenia.
The stratifi ed site of Obishir-5 is one of the most important Final Pleistocene to Early Holocene sites in western Central Asia. In the Early Holocene component (10,700–8200 cal BP) of this site (layers 2 and 3), we discovered one of the oldest and largest assemblages of soft stone ornaments known from the region. It includes 5 items: three oval, sub-triangular, and sub-rectangular pendants, one“labret”-like ornament, and one ornament blank. All specimens come from stratifi ed and well-dated contexts. As a result of the petrographic, experimental, use-wear, and technological analysis, we reconstructed the chaîne opératoire of these artifacts. To produce them, local raw materials (talcite and serpentinite) were transported from a source located 4.5 km away from the site. Small pebbles, shatters, and spalls split from nodules were used as blanks. The surface of the blank was fi rst prepared using grinders and burins, then biconical drilling and polishing were used to fi nish the artifact. Our results point to an established tradition of personal ornament production from soft stone in western Central Asia during the Early Holocene. Comparison of these nonutilitarian artifacts with those from other Final Pleistocene to Early Holocene archaeological complexes across Central Asia, the Middle East, and the Near East suggests that personal ornament manufacture may be an important hallmark of social developments across a broad geographic region.
Preoperative differential diagnosis of benign thyroid nodules and thyroid cancer is an important issue of endocrinology. Preoperative identification of a tumor type allows a surgeon to determine an adequate surgical treatment and reduce complications. The cytological analysis of samples obtained by the fine-needle aspiration biopsy is limited in sensitivity and specificity and the core biopsy is not safe to be used in patients with thyroid nodes smaller than 2 cm. The most promising area in the preoperative diagnosis of malignant tumors is molecular biomarkers, which can be used to determine the surgical treatment and indications for the target therapy. BRAF V600E is the most frequent genetic alteration in thyroid cancer. It activates the MAP-kinase pathway which causes changes in expression levels of extracellular matrix proteins and some of their receptors. Changes in the expression of integrin receptors and their ligands, such as osteopontin and thrombospondin-1, contribute to tumor cell proliferation and migration. The C-Jun pathway is also very important in pathogenesis of thyroid cancer. Changes in its activity can affect the expression of GSTP enzyme which participates in hormone metabolism. Altered MiRNA expression has been observed in a variety of cancer states allowing their potential use as cancer biomarkers.

The aim of this study was to evaluate integrins, angiogenic factors, GSTP and MiRNAs as potential biomarkers for the diagnosis and prognosis of thyroid cancer. 112 samples of papillary thyroid cancer (PTC) and 120 samples of benign nodular neoplasms were analyzed. The expression levels of the studied genes were determined by RT-PCR. The results were confirmed by immunohistochemical analysis. The BRAF V600E mutation was determined by allele-specific real-time PCR.

The results showed that GSTP can be used for clinical settings as a cancer-specific marker for thyroid neoplasms with 83–88% sensitivity, 70–80% specificity and 76–84% diagnostic accuracy. Higher expression levels of integrins α2, α5, αv, α9, β1, β3 and IL-8, angiogenin, and VEGF were observed in malignant tumors in comparison with the normal thyroid tissue (p < 0.05). The BRAF V600E mutation was detected in 70% of all PTC cases. In the BRAF V600E positive PTC samples the levels of ITGA3 and ITGAV expression were higher than in the BRAF V600E negative ones (p < 0.05). The expression of miRNA 21, 221, 222, 155 was significantly increased in the cancer samples compared to the benign neoplasms. Thus, the studied molecular markers could be used for preoperative diagnosis of thyroid neoplasms and the treatment approach.
We present a comprehensive analysis of photon emission and atomic collision processes in two-phase argon doped with xenon and nitrogen.The dopants are aimed to convert the VUV emission of pure Ar to the UV emission of the Xe dopant in the liquid phase and to the near UV emission of the N2 dopant in the gas phase.Such a mixture is relevant to two-phase dark matter and low energy neutrino detectors, with enhanced photon collection efficiency for primary and secondary scintillation signals.Based on this analysis, we show that the recently proposed hypothesis of the enhancement of the excitation transfer from Ar to N2 species in the two-phase mode is either incorrect or needs assumption about a new extreme mechanism of the excitation transfer coming into force at lower temperatures, in particular that of the resonant excitation transfer via ArN2 compound (van der Waals molecule).
Detection of perspective research areas in academic studies is of key importance for successful development and enhancement of the competitive performance of research organizations, universities, and the country. This task is usually solved by the expert community; however, the use of results of bibliometric analysis can give significant support to experts for informed decisions.

The paper uses a case study of Earth Sciences to present a bibliometric model for the detection of perspective research in individual research organizations. The model is based on multiplex analysis of publications from the analyzed organization using content analysis and citation analysis.
Stable free radicals are widely used as molecular probes and labels in various biophysical and biomedical research applications of magnetic resonance spectroscopy and imaging. Among these radicals, sterically shielded nitroxides of pyrrolidine series demonstrate the highest stability in biological systems. Here, we suggest new convenient procedure for preparation of 3-carboxy-2,2,5,5-tetraethylpyrrolidine-1-oxyl, a reduction-resistant analog of widely used carboxy-Proxyl, from cheap commercially available reagents with the yield exceeding the most optimistic literature data. Several new spin labels and probes of 2,2,5,5-tetraethylpyrrolidine-1-oxyl series were prepared and reduction of these radicals in ascorbate solutions, mice blood and tissue homogenates was studied.
The initial stage of controlled decay of metastable liquid was studied under pulsed heating on the surface of the flat microheater using the optical method of reflected laser beam.

Four major stages of fluids explosive boiling and phase explosion on microheater were determined.

The dynamics of filling the heater surface with the vapor phase, the lifetime of the main vapor bubble, and the satellite bubble are estimated.
КАРДИОРЕСПИРАТОРНЫЕ РЕАКЦИИ НА ГИПОКСИЮ И ГИПЕРКАПНИЮ У ПЛОВЦОВ

В. Э. Диверт, Т
The weighted method of dependent trials or weighted method of correlated sampling (MCS) allows one to construct estimators for functionals based on the same Markov chain simultaneously for a given range of the problem parameters. Choosing an appropriate Markov chain, it is necessary to take into account additional conditions providing the finiteness of the computational cost of weighted MCS. In this paper we study the issue of finite computational cost of the method of correlated sampling (MCS) in application to evaluation of linear functionals of solutions to a set of systems of 2nd kind integral equations. A universal modification of the vector weighted MCS is constructed providing the branching of chain trajectory according to elements of matrix weights. It is proved that the computational cost of the constructed algorithm is bounded in the case the base functionals are also bounded. The results of numerical experiments using the modified weighted estimator are presented for some problems of the theory of radiation transfer subject to polarization.
The article attempts to assess the possible parameters of the state of mechanical engineering in Russia in the event of a significant increase in the export of its products provided for by the national project 'International Cooperation and Export'.

Evaluation of hypothetical investments in the implementation of intentions to increase the export of engineering products was carried out according to the table of use of domestic products at basic prices from the Rosstat system of input-output tables. At the same time, the original table was transformed into a worksheet with the inclusion of the investment unit, as a result of calculations on which, apart from hypothetical investments equal to the difference between the initial and estimated values of fixed assets, the impact on the output of economic activities related to engineering was determined.

The evaluation of the parameters is based on the premise that an increase in the export of engineering products will entail an increase in the volume of its production (provided that there is no decrease in domestic consumption) in the country, which in turn will necessitate a possible re-equipment and reconstruction of existing industries and the creation of new ones. In addition, increasing the output of competitive high-tech products will require increased R&D and the creation of related organizations. All this in total may require significant investment.
Deposition of a SiO2 shell on luminescent ZnO nanoparticles in dimethylsulfoxide precisely tunes the nanoparticle size from 3 to 6 nm.
Hyperpolarized forms of 1-13C-acetates and 1-13C-pyruvates are used as diagnostic contrast agents for molecular imaging of many diseases and disorders. Here, we report the synthetic preparation of 1-13C isotopically enriched and pure from solvent acetates and pyruvates derivatized with unsaturated ester moiety. The reported unsaturated precursors can be employed for NMR hyperpolarization of 1-13C-acetates and 1-13C-pyruvates via parahydrogen-induced polarization (PHIP). In this PHIP variant, Side arm hydrogenation (SAH) of unsaturated ester moiety is followed by the polarization transfer from nascent parahydrogen protons to 13C nucleus via magnetic field cycling procedure to achieve hyperpolarization of 13C nuclear spins. This work reports the synthesis of PHIP-SAH precursors: vinyl 1-13C-acetate (55% yield), allyl 1-13C-acetate (70% yield), propargyl 1-13C-acetate (45% yield), allyl 1-13C-pyruvate (60% yield), and propargyl 1-13C-pyruvate (35% yield). Feasibility of PHIP-SAH 13C hyperpolarization was verified by 13C NMR spectroscopy: hyperpolarized allyl 1-13C-pyruvate was produced from propargyl 1-13C-pyruvate with 13C polarization of ∼3.2% in CD3OD and ∼0.7% in D2O. 13C magnetic resonance imaging is demonstrated with hyperpolarized 1-13C-pyruvate in aqueous medium.
Due to strong enhancement of loop effects in a superstrong magnetic field (B ≫ m 2 =e 3 ) the Coulomb potential becomes screened. This phenomenon dramatically changes the dependence of the electron energy levels on magnetic field. In particular, the freezing of energy levels occurs so the ground energy level of light ions can never reach the lower continuum (become critical), no matter how strong the field is. Therefore, the magnetic field affects the critical nucleus charge Z cr in two ways: i. it makes the electron movement essentially one-dimensional diminishing the value of Z cr ; ii. it makes the potential weaker increasing the value of critical charge. The phenomenon of critical charge itself is also discussed.
In this work we derive conditions under which a level-crossing line in a magnetic field effect curve for a recombining radical pair will be equivalent to the electron spin resonance (ESR) spectrum and discuss three simple rules for qualitative prediction of the level-crossing spectra.
An S-ring (a Schur ring) is said to be separable with respect to a class of groups K if every algebraic isomorphism from the S-ring in question to an S-ring over a group from K is induced by a combinatorial isomorphism. A finite group is said to be separable with respect to K if every S-ring over this group is separable with respect to K.

We provide a complete classification of abelian p-groups separable with respect to the class of abelian groups.

We provide a complete classification of abelian p-groups separable with respect to the class of abelian groups.
The field of zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is currently experiencing rapid growth, owing to progress in optical magnetometry and attractive features of ZULF-NMR such as low hardware cost and excellent spectral resolution achieved under ZULF conditions.

In this work, an approach is proposed and demonstrated for simultaneous acquisition of ZULF-NMR spectra of individual 13C-containing isotopomers of chemical compounds in a complex mixture. The method makes use of fast field cycling such that the spin evolution takes place under ZULF conditions, whereas signal detection is performed in a high-field NMR spectrometer.

This method has excellent sensitivity, also allowing easy assignment of ZULF-NMR spectra to specific analytes in the mixture. We demonstrate that the spectral information is the same as that given by ZULF-NMR, which makes the method suitable for creating a library of ZULF-NMR spectra of various compounds and their isotopomers. The results of the field-cycling experiments can be presented in a convenient way as 2D-NMR spectra with the direct dimension giving the high-field 13C-NMR spectrum (carrying the chemical-shift information) and the indirect dimension giving the ZULF-NMR spectrum (containing information about proton–carbon J-couplings). Hence, the method can be seen as a variant of heteronuclear J-resolved spectroscopy, one of the first 2D-NMR techniques.
Newton's rings are an interference pattern related to fringes of equal thickness. This image can be obtained on a simple experimental optical setup. Modern common renderers, based on zerothickness ray tracing, calculate highly realistic images of complex 3D scenes, which are computer models of scenes from the real world. However, they do not allow you to reproduce such phenomena as interference, because they ignore even the polarization of light. Interference is studied by physical optics, and it is natural to assume that if the calculation is based on the "tracing" of waves in the scene, this problem can be solved. An algorithm is known when a solid beam of light is used instead of a light wave. The results of the calculations show images of the interference effects; Newton's rings are also calculated. This is an acceptable solution for simple scenes involving a few objects. It is also good for optical design systems, when the result is important, and not the time spent. But not practical for universal renderers, which must calculate the image in an acceptable time for very complex scenes. In this paper, we propose an algorithm based on the traditional method of tracing paths consisting of zero-thickness rays. Only on the last ray of a path that crosses the picture plane is the modification made. It is assumed that these rays characterize spherical wavelets. In this paper, we consider the results of applying the mentioned heuristics to classical optical experiments.
We study the asymptotic behavior of the survival probability of a multi-type branching process in a random environment.

In the one-dimensional situation, the class of processes considered corresponds to the strongly subcritical case.

We also prove a conditional limit theorem describing the distribution of the number of particles in the process given its survival for a long time.
In the framework of the method for producing gas hydrates based on the self-organizing cyclic boiling-condensation process of a hydrate-forming gas in a water volume

a study was conducted aimed at determining the effect of the boiling intensity of liquefied gas in the water volume on the hydrate formation process
Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)-mediated cascade of excitation and inhibition responses observed in MSN intracellular signal transduction is crucial for neuroscience research due to its involvement in the motor and behavioral functions. In particular, all types of addictions are related to MSNs. Shedding the light on the mechanics of the above-mentioned cascade is of primary importance for this research domain.
We describe a general N-solitonic solution of the focusing nonlinear Schrödinger equation in the presence of a condensate by using the dressing method.

We give the explicit form of one- and two-solitonic solutions and study them in detail as well as solitonic atoms and degenerate solutions. We distinguish a special class of solutions that we call regular solitonic solutions. Regular solitonic solutions do not disturb phases of the condensate at infinity by coordinate. All of them can be treated as localized perturbations of the condensate. We find a broad class of superregular solitonic solutions which are small perturbations at a certain moment of time. Superregular solitonic solutions are generated by pairs of poles located on opposite sides of the cut.

They describe the nonlinear stage of the modulation instability of the condensate and play an important role in the theory of freak waves.
Adjuvant chemotherapy with temozolomide (TMZ) is an intrinsic part of glioblastoma multiforme (GBM) therapy targeted to eliminate residual GBM cells. Despite the intensive treatment, a GBM relapse develops in the majority of cases resulting in poor outcome of the disease. Here, we investigated off-target negative effects of the systemic chemotherapy on glycosylated components of the brain extracellular matrix (ECM) and their functional significance. Using an elaborated GBM relapse animal model, we demonstrated that healthy brain tissue resists GBM cell proliferation and invasion, thereby restricting tumor development. TMZ-induced [especially in combination with dexamethasone (DXM)] changes in composition and content of brain ECM proteoglycans (PGs) resulted in the accelerated adhesion, proliferation, and invasion of GBM cells into brain organotypic slices ex vivo and more active growth and invasion of experimental xenograft GBM tumors in SCID mouse brain in vivo . These changes occurred both at core proteins and polysaccharide chain levels, and degradation of chondroitin sulfate (CS) was identified as a key event responsible for the observed functional effects. Collectively, our findings demonstrate that chemotherapy-induced changes in glycosylated components of brain ECM can impact the fate of residual GBM cells and GBM relapse development. ECM-targeted supportive therapy might be a useful strategy to mitigate the negative off-target effects of the adjuvant GBM treatment and increase the relapse-free survival of GBM patients.