Hengzongshu/ArticleAgent huggingface dataset:
The arginine repressor ArgR/AhrC is a transcription factor universally conserved in bacterial genomes. Its recognition signal (the ARG box), a weak palindrome, is also conserved between genomes, despite a very low degree of similarity between individual sites within a genome. Thus, the arginine repressor is different from two other universal transcription factors - HrcA, whose recognition signal is very strongly conserved both within and between genomes, and LexA/DinR, whose signal is strongly conserved within, but not between, genomes. The arginine regulon is well studied in Escherichia coli and to some extent in Bacillus subtilis and some other genomes.

Here, we apply the comparative genomic approach to the prediction of the ArgR-binding sites in all completely sequenced bacterial genomes. Orthologs of ArgR/AhrC were identified in the complete genomes of E. coli, Haemophilus influenzae, Vibrio choleras, B. subtilis, Mycobacterium tuberculosis, Thermotoga maritima, Chlamydia pneumoniae and Deinococcus radiodurans. Candidate arginine repressor binding sites were identified upstream of arginine transport and metabolism genes.

We found that the ArgR/AhrC recognition signal is conserved in all genomes that contain genes encoding orthologous transcription factors of this family. All genomes studied except M. tuberculosis contain ABC transport cassettes (related to the Art system of E. coli) belonging to the candidate arginine regulons.
classical S.N.Bernstein's theorem on polynomial deviations of the Fejer sums for Holder functions and theorem about polynomial rates of convergence in von Neumann's ergodic theorem

The Fejer sums for measures on the circle and the norms of the deviations from the limit in von Neumann's ergodic theorem are calculated, in fact, using the same formulas (by integrating the Fejer kernels) and so, this ergodic theorem is a statement about the asymptotics of the Fejer sums at zero for the spectral measure of the corresponding dynamical system

It made it possible, having considered the integral Holder condition for signed measures, to prove a theorem that unies both following well-known results
Bread wheat producing grain in which the pericarp is purple is considered to be a useful source of dietary anthocyanins. The trait is under the control of the Pp-1 homoealleles (mapping to each of the group 7 chromosomes) and Pp3 (on chromosome 2A). Here, TaMyc1 was identified as a likely candidate for Pp3. The gene encodes a MYC-like transcription factor. In genotypes carrying the dominant Pp3 allele, TaMyc1 was strongly transcribed in the pericarp and, although at a lower level, also in the coleoptile, culm and leaf. The gene was located to chromosome 2A. Three further copies were identified, one mapping to the same chromosome arm as TaMyc1 and the other two mapping to the two other group 2 chromosomes; however none of these extra copies were transcribed in the pericarp. Analysis of the effect of the presence of combinations of Pp3 and Pp-1 genotype on the transcription behavior of TaMyc1 showed that the dominant allele Pp-D1 suppressed the transcription of TaMyc1.
One of the effective tools for solving applied problems of analysis and modeling of the spatial economy are optimization interregional intersectoral models. Currently, IEIE SB RAS has developed and implemented several versions of the Model-Program Complex of the Optimization Interregional Interindustry Model "MPK OMMM", which are used to coordinate macroeconomic, sectoral and regional long-term forecasts on a regular basis and for experimental calculations of forecast options for the development of the national economy of the Russian Federation . This paper discusses one of the ways to represent optimization models of the OMMM type, based on the use of the COMBI-2000 language (Complex for processing matrix information blocks, version 2000), which is a tool for describing pre- and post-optimization calculations, a means of communication with the optimization package and reflecting a database and recording mathematical models in a fairly convenient and simplified structure for users.
We propose the study of the inclusive hadroproduction of a heavy-flavored jet in association with a light jet, as a probe channel of strong interactions at high energies.

We build up a hybrid factorization that encodes genuine high-energy effects, provided by a partial next-to-leading BFKL resummation, inside the standard collinear structure of the cross section. We present a detailed analysis of different distributions, shaped on kinematic ranges typical of experimental analyses at the Large Hadron Collider, and differential in rapidity, azimuthal angle and transverse momentum.

The fair stability that these distributions exhibit under higher-order corrections motivates our interest toward future studies. Here, the hybrid factorization could help to deepen our understanding of heavy-flavor physics in wider kinematic ranges, like the ones accessible at the Electron-Ion Collider.
The production of Upsilon(1S), Upsilon(2S) and Upsilon(3S) mesons in proton-proton collisions at the centre-of-mass energy of sqrt(s)=7 TeV is studied with the LHCb detector.

The analysis is based on a data sample of 25 pb-1 collected at the Large Hadron Collider. The Upsilon mesons are reconstructed in the decay mode Upsilon -> mu+ mu- and the signal yields are extracted from a fit to the mu+ mu- invariant mass distributions. The differential production cross-sections times dimuon branching fractions are measured as a function of the Upsilon transverse momentum pT and rapidity y, over the range pT < 15 GeV/c and 2.0 < y < 4.5.

The integrated cross-sections in this kinematic region, assuming unpolarised production, are measured to be sigma(pp -> Upsilon(1S) X) x B(Upsilon(1S)->mu+ mu-) = 2.29 {\pm} 0.01 {\pm} 0.10 -0.37 +0.19 nb, sigma(pp -> Upsilon(2S) X) x B(Upsilon(2S)->mu+ mu-) = 0.562 {\pm} 0.007 {\pm} 0.023 -0.092 +0.048 nb, sigma(pp -> Upsilon(3S) X) x B(Upsilon(3S)->mu+ mu-) = 0.283 {\pm} 0.005 {\pm} 0.012 -0.048 +0.025 nb, where the first uncertainty is statistical, the second systematic and the third is due to the unknown polarisation of the three Upsilon states.
In this study, we propose to model the operation of a service concession arrangement in the economic area of municipal heat supply utilities. We offer a scheme of interaction between the concedent and concessionaire in this concessionary arrangement. Currently, the existing regulations regarding the temperature of coolant focusses on the daily average outdoor temperature, and the determination of a “normative” demand for heat energy. On any day of the heating period, this demand is a random variable, whose distribution can be described through the distribution of daily average air temperature. In our model, heat energy is paid for at a fixed price, and the concessionaire pays a penalty for each unit of unsatisfied normative demand. The price and penalty values are the concession parameters, and are determined by the concedent. The concedent’s goal is to minimise the thermal energy cost; the concessionaire’s purpose is to maximise profit. The interaction is formalised as a two-move game model. First, the concedent determines the price and the value of the penalty. Then the concessionaire selects the capacity to be created. The concession’s parameters should be set so that the individual rationality and incentive compatibility conditions are met. Our results prove the existence of Stackelberg equilibrium, and we derive the relevant formulas for computing its parameters. In equilibrium, the optimum capacity for the concessionaire provides a sufficient probability of meeting demand. The price of thermal energy is minimal under this condition. We also formulate a one-parameter model (thermal energy price as a parameter), which is based on a typical concession scheme. In the two-parameter model, the equilibrium capacity and price do not exceed the corresponding parameters of the one-parameter model. The main advantage of the two-parameter model is an “embedded” economic mechanism that prevents the concessionaire’s opportunistic behaviour. By contrast, in the one-parameter model there is no such mechanism. The proposed approach can be applied to a concession for the production of any good or service, provided the concerned parties are interested in the availability and reliability of meeting a corresponding need, which may be described as a random variable. However, typical concession schemes do not penalise unsatisfied demand, so the implementation of our two-parametric model is possible only after modification of the pertinent concession legislation.
Automatic brain tumor segmentation from CT or MRI scans is one of the crucial problems among other directions and domains where daily clinical workflow requires to put a lot of efforts while studying patients with various pathologies.

In this paper, we report the results of the research project 'Brain Tumor Segmentation' organized in conjunction with the Federal Neurosurgical Center. Several state-of-the-art tumor segmentation algorithms were applied to a set of 100 MRI scans of meningioma, neurinoma and glioma patients -manually annotated by up to three raters -and to 100 comparable scans obtained using the automated tumor multi-region segmentation.

Quantitative evaluations revealed a considerable agreement between the human raters in segmenting various tumor subregions (Dice scores in the range 85-90%). We found that different algorithms worked best for different sub-regions, but no single algorithm ranked in the top for all subregions simultaneously.
The data presented in this article are related to the research article entitled "Structure and electrochemical characterization of SnOx/[email protected] composites formed by pulsed ion beam irradiation" (Korusenko et al., 2019). This article presents the effect of irradiation by pulsed ion beam (PIB) irradiation at various modes on the structure multi-walled carbon nanotubes (MWCNTs) and composites based on MWCNTs and tin oxide as well as cycling performance of these composites. The article also presents the results of the analysis of the structure of the electrodes, obtained on the basis of the initial and irradiated composites.
There is currently no approved antiviral therapy for treatment of Marburg virus disease (MVD). Although filovirus infection outbreaks are quite rare, the high mortality rates in such outbreaks make the development of anti-filoviral drugs an important goal of medical chemistry and virology. Here, we performed screening of a large library of natural derivatives for their virus entry inhibition activity using pseudotype systems. The bornyl ester derivatives containing saturated N-heterocycles exhibited the highest antiviral activity. It is supposed that compounds with specific inhibitory activity toward MarV-GP-dependent virus entry will inhibit the rVSIV-ΔG-MarV-GP pseudotype much more efficiently than the control rVSIV-ΔG-G pseudotype. At the same time, the compounds similarly inhibiting both pseudotypes will likely affect rVSIV capsid replication or the cellular mechanisms common to the entry of both viruses. Borneol itself is not active against both pseudotypes and is nontoxic, whereas its derivatives have varying toxicity and antiviral activity. Among low-toxic borneol derivatives, six compounds turned out to be relatively specific inhibitors of MarV-GP-mediated infection (SC > 10). Of them, compound 6 containing a methylpiperidine moiety exhibited the highest virus-specific activity. Notably, the virus-specific activity of this compound is twice as high as that of the reference.
To study indicators of bone mineral densit (BMD) and trabecular bone score (TBS) and to reveal the 10-year fracture risk (FRAX®) taking into account the data obtained in persons with type 2 diabetes (DM2).A clinical study of the type of case - control. The study included 122 people with and without DM2. All persons were: questionnaires, anthropometry, densitometry, determination of TBS and fracture risk on the FRAX®.Persons with DM2 who underwent a fracture had lower T-score values in all areas except the spine, unlike those with DM2, but without fracture. However, persons with DM2 had a fracture at high values of T-score in vertebrae and hips in comparison with persons without DM. Using the TBS, we did not get a significant difference in any of the examined groups. We also found no differences in the risk of recurrent fractures among women with and without DM2 using FRAX® without densitometry and FRAX® adjusted for TBS. The values of FRAX® by T-score in the group of persons with DM with fractures were significantly lower (p=0.029 for major fractures, p=0.024 for hip fractures) than in persons without DM with fractures.Persons with DM2 and fractures have higher BMD values, lower than the FRAX fracture risk values adjusted for the T-score, do not differ significantly in TBS, which determines the difficulties in diagnosis, the need to find additional methods for early diagnosis of increased fracture risk in patients with DM2.Цель исследования. Изучить показатели минеральной плотности кости (МПК), трабекулярного костного индекса (ТКИ) и определить 10-летний риск переломов (FRAX®) с учетом полученных данных у лиц с сахарным диабетом 2-го типа (СД2). Материалы и методы. Проведено клиническое исследование по типу случай - контроль. Обследовано 122 человека с СД2 и без него. Всем лицам проведены: анкетирование, антропометрия, денситометрия, определение ТКИ и риска переломов по шкале FRAX®. Результаты и обсуждение. Лица с СД2, перенесшие перелом, имели более низкие показатели Т-критерия в шейке бедра, в отличие от лиц с СД2, но без перелома. Однако лица с СД2 имели перелом при больших значениях Т-критерия в позвонках и бедрах в сравнении с лицами без СД. Используя параметр ТКИ, мы не получили достоверной разницы ни в одной из обследованных групп. Также мы не нашли различий по риску повторных переломов среди женщин с СД2 и без него при помощи FRAX® без учета денситометрии и FRAX® с поправкой на ТКИ (р=0,841 и р=0,094, соответственно). Значения FRAX® с учетом Т-критерия в группе лиц с СД2 и переломами значимо ниже для основных переломов (р=0,029) и переломов бедра (р=0,024), чем у лиц без СД с переломами. Заключение. Лица с СД2 и переломами имеют более высокие значения МПК, более низкие значения риска переломов по FRAX® c поправкой на Т-критерий, не отличаются значимо по ТКИ, что определяет сложности в диагностике, необходимость поиска дополнительных методов ранней диагностики повышенного риска переломов у пациентов с СД2.
Increase in organism complexity is a global trend in evolution. Qualitatively extended complexity in eukaryotes in comparison to prokaryotes is provided by genome organization and genetic program realization.

Genetic mechanisms of encoding biological complexity in pro- and eukaryotes are considered: above-triplet codes, combinatorial analysis of genetical blocks and gene network blocks, and their hierarchical interaction
In this paper we study properties of the model, that describes the plane acoustic waves propagation. The model is based on the hyperboliv system of PDE, which is solved numerically by using the finite-volume method, based on Godunov scheme.

After studying the direct problem we turn to the inverse one, where our goal is to recover the parameters of the system of PDE by using the initial data, measured in the receivers. We obtain the formula for the gradient of the misfits functional, which allows us to apply gradient-based optimization for recovering the density of the medium.

We present the results of numerical experiments for different number of receivers, thus, studying the influence of the quantity of the data of inverse problem on the accuracy of the solution.
The nanoplatelets are rectangular colloidal nanocrystals, with thicknesses of core and shell layers of a few nanometers.

We report the phonon spectra of core/shell CdSe/CdS nanoplatelets with different shell thicknesses studied using Raman scattering. The Raman spectra show features corresponding to the dominating longitudinal optical (LO) and surface optical (SO) phonon modes of the CdSe core in CdS shell located in the frequency regions of 200-210 and 250-290 cm -1 , respectively.

As the shell thickness increases, the phonon modes reveal a frequency shift and a change in intensity. The frequency shift associated with a change in the stress state in the core and shell, as well as with confinement effects is discussed. The phonon mode intensities are determined by the thickness of the shell and the proximity to resonant Raman scattering conditions.
The paper describes a series of behavioral interventions carried out by the staff of the interdisciplinary Center of Applied Behavioral Analysis of the Novosibirsk State University and aimed at teaching verbal operants to children with autism spectrum disorder (ASD). The paper analyzes how the children acquire verbal behaviors of mands (demands), echoics (imitations), tacts (naming or labelling) and intraverbals (conversations), as well as provides descriptions of trainings.
This paper presents an experimental study of evaporation of a millimeter-sized sessile water droplet into open atmosphere in a wide range of the temperature difference (from 0 to 76 K) between the solid substrate and the atmosphere.

The study was performed using two substrates made of copper. One of them had no coating and was polished to the root mean square roughness of about 20 nm. Another one was coated with a micrometer-thick film of single-walled carbon nanotubes. With the help of precise drop shape analysis system, the mode of droplet evaporation with pinned contact line was studied.

No appreciable difference was detected in evaporation droplet dynamics between the two substrates for the substrate temperatures from 24 to 100 °C.
The article analyzes the problems of sustainable development of Russia's resource regions, where the extraction of natural resources is at a declining stage.

The economic indicators of the development projects with application of advanced extraction technologies to increase production efficiency were estimated.

It was revealed that high costs of installation and application of advanced technologies do not allow for the full application, especially under the conditions of highly volatile oil prices and limitations on usage of foreign technologies. Measures to optimize the structure of costs and increase the overall efficiency of implementation of innovations in resource regions were proposed.
Poly(ADP-ribosyl)ation (PARylation) is posttranslational modification of proteins by linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme for PAR production in cells and the main target of poly(ADP-ribosyl)ation during DNA damage is poly(ADP-ribose) polymerase 1 (PARP1). PARP1 ability to function as a catalytic and acceptor protein simultaneously made a considerable contribution to accumulation of contradictory data. This topic is directly related to other questions, such as the stoichiometry of PARP1 molecules in auto-modification reaction, direction of the chain growth during PAR elongation and functional coupling of PARP1 with PARylation targets. Besides DNA damage necessary for the folding of catalytically active PARP1, other mechanisms appear to be required for the relevant intensity and specificity of PARylation reaction. Indeed, in recent years, PARP research has been enriched by the discovery of novel PARP1 interaction partners modulating its enzymatic activity. Understanding the details of PARP1 catalytic mechanism and its regulation is especially important in light of PARP-targeted therapy and may significantly aid to PARP inhibitors drug design. In this review we summarize old and up-to-date literature to clarify several points concerning PARylation mechanism and discuss different ways for regulation of PAR synthesis by accessory proteins reported thus far.
Dismembered ophiolites in the Early Paleozoic Olkhon terrane, a part of the Baikal collisional belt in the southern periphery of the Siberian craton, occur as fault-bounded blocks of ultramafic and mafic rocks from a few meters to hundreds of meters in size. The ultramafic rocks are mainly dunite–harzburgite peridotites with gradual transitions between the lithologies, as well as moderate amounts of enstatitite, wehrlite, and clinopyroxenite, but no lherzolite. Most peridotites have strongly depleted chemistry and a mineralogy corresponding to the harzburgite type usual for ophiolites of suprasubduction zones (SSZ). The mafic rocks are leuco- to melanocratic gabbros with different relative percentages of clinopyroxene, olivine, and plagioclase, which enclose thin layers and lenses of clinopyroxenite and anorthosite. They bear back-arc basin geochemical signatures, a setting inferred for the Neoproterozoic southern Siberian craton. The gabbroic rocks are of two geochemical groups; most of their trace-element patterns show Ta-Nb minimums and Sr maximums common to suprasubduction zone ophiolites. Judging by the Ol + Opx + Chl + Chr mineral assemblages, the Olkhon peridotites underwent low amphibolite and amphibolite regional metamorphism at 500–650 °C. The occurrence of the ultramafic and mafic bodies is consistent with formation in an accretionary wedge metamorphosed during a collisional orogeny. The mantle and crustal parts of the Olkhon ophiolite suite apparently were incorporated into the terrane during the frontal collision of perio-oceanic structures with the Siberian craton. Then, in a later oblique collision event, they became dismembered by strike-slip faulting into relatively small bodies and fault blocks exposed in the present erosional surface.
Background: Plasma enriched in growth factors is widely used in medical practice. However, the clinical efficacy of its application in the treatment of age-related retinal integrity violations is investigated insufficiently.

A three-port subtotal transconjunctival vitrectomy was performed and administration of the autologous plasma enriched with platelet lysate was indicated. Autologous plasma enriched with platelet lysate was received from the peripheral blood. We assessed visual acuity, intraocular pressure; conducted optical coherent tomography examination of the eye on the side of the pathological process.

The study demonstrated that the combination of a standard 3-port transconjunctival subtotal vitrectomy followed by tamponade of the gap using the autologous plasma enriched with platelet lysate with the injections of the autologous plasma enriched with platelet lysate in the area of pterygopalatine fossa on the side of the operated eyes statistically significantly promoted recovery of the visual acuity in the early postoperative period (15 days) and late period (90 days) if compared with patients who received only surgical treatment (p≤0.05). Use of the autologous plasma enriched with platelet lysate in the treatment increased the closing rate of the tearing of the retina in the macular region up to 62,5%, while only surgical treatment leads to the closure of the defect of the retina in 37.5% of cases. The study showed that autologous plasma enriched with platelet lysate contains cytokines, growth factors, and nitric oxide which are involved in the regeneration/reparation of the retina. Conclusions: Additional administration of the autologous plasma enriched with platelet lysate in the scheme of treatment patients with age-related macular degeneration is accelerating the closure of retinal tears of the eye and improves visual acuity.