Hengzongshu/ArticleAgent huggingface dataset:
Aim . To study the possibility of conducting an educational program “Primary and Secondary Prevention of Cardiovascular Diseases (CVD)”, aimed at increasing health literacy among followers of cardiology blogs on Instagram. Material and methods . The methodology for conducting an educational program on Instagram included following items: the choice of agents of influence and the forms of engagement with audience; development of evaluation metric; carrying out he program; evaluation of the results obtained; defining a scaling strategy. The educational program was conducted daily from March 19 to March 30, 2020 on Instagram in following medical accounts: @doc_4_you, @zdorovye_serdtsa, @doctor_isaeva_cardio, @dr_cardioann, @doctor_savonina, @cardiolog.novikova, @doctor_lobzhanidze, @dnevnik.doctora, @doc.for.health, @aksenova_doctor. The format is publications of up to 4 thousand characters dedicated to informing people about primary (proper nutrition, quitting smoking, physical activity, obesity, vegetarianism) and secondary prevention (drug treatment) of CVD. The assessment of the results was carried out using descriptive statistics. Results . The total number of followers of cardiology blogs is 367,727. The audience of professional doctors' accounts is mostly female (from 89 to 95%), the 25 to 34 age group accounts for 40 to 47% of followers. The total number of followers who read 10 publications of the educational program was 104 794; the total audience involvement (comments, reposts, likes, saves) was 9,692 people. The greatest involvement of people was revealed in the following topics — consumption of vegetables, salt and sugar, physical activity, obesity (1146, 1100, 2195, 1052, 1534 people, respectively). Conclusion . The social networking service Instagram can be used to conduct educational programs aimed at improving the health literacy of Russian people. It is necessary to further improve the methodology for conducting research in social networks, in order to select the most effective technologies in this topic.
We study the hadronic decays of to the final states and , using an annihilation data sample of 567 pb -1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCII collider. We find evidence for the decays and with statistical significance of and , respectively. Normalizing to the reference decays and , we obtain the ratios of the branching fractions and to be and , respectively. The upper limits at the 90% confidence level are set to be and . Using BESIII measurements of the branching fractions of the reference decays, we determine % (<0.68%) and % (<1.9%). Here, the first uncertainties are statistical and the second systematic. The obtained branching fraction of is consistent with the previous measurement, and the branching fraction of is measured for the first time.
Three available chemical kinetic models were tested.

Flame structure of laminar premixed HC(O)OH/O2/Ar was studied both experimentally and numerically.

In general, all models agree with experimental results for H2O, CO, O2, CO2, HC(O)OH within the experimental error. For most of the intermediates all the models well capture the peak position and concentration profiles shape.
Motivation Computational identification of promoters is notoriously difficult as human genes often have unique promoter sequences that provide regulation of transcription and interaction with transcription initiation complex. While there are many attempts to develop computational promoter identification methods, we have no reliable tool to analyze long genomic sequences.

Results In this work, we further develop our deep learning approach that was relatively successful to discriminate short promoter and non-promoter sequences. Instead of focusing on the classification accuracy, in this work we predict the exact positions of the transcription start site inside the genomic sequences testing every possible location. We studied human promoters to find effective regions for discrimination and built corresponding deep learning models. These models use adaptively constructed negative set, which iteratively improves the model's discriminative ability.

Our method significantly outperforms the previously developed promoter prediction programs by considerably reducing the number of false-positive predictions. We have achieved error-per-1000-bp rate of 0.02 and have 0.31 errors per correct prediction, which is significantly better than the results of other human promoter predictors. Availability and implementation The developed method is available as a web server at http://www.cbrc.kaust.edu.sa/PromID/.
Accumulation of complete genome sequences of diverse organisms creates new possibilities for evolutionary inferences from whole-genome comparisons.

In the present study, we analyze the distributions of substitution rates among proteins encoded in 19 complete genomes (the interprotein rate distribution). To estimate these rates, it is necessary to employ another fundamental distribution, that of the substitution rates among sites in proteins (the intraprotein distribution). Using two independent approaches, we show that intraprotein substitution rate variability appears to be significantly greater than generally accepted. This yields more realistic estimates of evolutionary distances from amino-acid sequences, which is critical for evolutionary-tree construction.

We demonstrate that the interprotein rate distributions inferred from the genome-to-genome comparisons are similar to each other and can be approximated by a single distribution with a long exponential shoulder. This suggests that a generalized version of the molecular clock hypothesis may be valid on genome scale. We also use the scaling parameter of the obtained interprotein rate distribution to construct a rooted whole-genome phylogeny. The topology of the resulting tree is largely compatible with those of global rRNA-based trees and trees produced by other approaches to genome-wide comparison.
Purpose. In this article, one of the brightest publicist compositions of M. Gorky – “Untimely thoughts” is being considered. The main platform, where the author’s essays was being publicized, is the “New life” newspaper, which was established with V. A. Desnitsky in April of 1917 and closed by personal disposition of V. I. Lenin in July of 1918. After closing of the newspaper, in 1920 the author decided to publish separate book, augmented it with essays from another cycle “Revolution and culture” and exchanged chronological principle of positioning of the material with thematic one. Results. In this article is pointed, that, as a result of changes, the book has loosed some features, inherent to journalistic discourse with it linear time sequence, but gained new features, which have amplified artistic-publicistical speech of the text, which took more generalized meaning along with the documentary material. Gaining of balance between an entinema and an example as a way to expand the material have been became the important principle of the book’s poetics. Artistic method, discovered by L. N. Tolstoy in “Anna Karenina” and “Resurrection”, made Gorky able to demystificate thesis about humanin character of events of 1917–1918 years and occupy objective view on the revolution, avoiding influence of Bolshevik’s press and defamation, peculiar to counterrevolution publications. Conclusion. Also, true anatomical view on the Russian revolution haven’t deliver Gorky from utopical hope for culture as a remedy for the social rescue. In this utopia, prerequisites of the future union between Gorky and Bolsheviks, which caused ambiguous reaction of descendants, already appeared.
Foraminifer is a very useful microorganism to perform biostratigraphical zonation of the Upper Jurassic. Foraminiferal biozones are calibrated by the ammonite standard zones and can be used for intra- and interregional correlations. Furthermore, the fossil record of foraminiferal faunas is well known among basins of the Northern Eurasia and is also used for accurate palaeoenvironmental, palaeobiogeographical, or biofacial reconstructions. It allows identifying a complex set of biotic and abiotic events which may be used to propose a more general palaeoecoloecological and palaeoceanographical reconstruction of the Subboreal, Boreal, and Arctic seas. Then, the late Kimmeridgian Northern Eurasian seas formed a network of well-connected palaeobasins during the sea-level rise and resulted in rather similar palaeoenvironmental conditions.
The article presents the results of research, showing the possibility of determining the stability losing of gas well casing using the passive method of standing waves determination from seismoacoustic noise.

It is shown that the amplitude spectrum of natural vibrations recorded on the gas well casing make it possible to reliably diagnose the instability of the casing.
SABRE is a method, which utilizes spin order transfer from para-hydrogen to the spins of a substrate in transient complexes using suitable catalysts. Such a transfer of spin order is efficient at low magnetic fields, notably, in the Level Anti-Crossing (LAC) regions.

A new technique is proposed to carry out Signal Amplification By Reversible Exchange (SABRE) experiments at high magnetic fields. Here it is demonstrated that LAC conditions can also be fulfilled at high fields in the rotating reference frame under the action of an RF-field. Spin mixing at LACs allows one to polarize substrates at high fields as well.

The achievable NMR enhancements are around 360 for the ortho-protons of partially deuterated pyridine used as a substrate and around 700 for H2 and substrate in the active complex with the catalyst. High-field SABRE effects have also been found for several other molecules containing a nitrogen atom in the aromatic ring.
Incompressible three-dimensional Euler equations develop high vorticity in very thin pancake-like regions from generic large-scale initial conditions. In this work, we propose an exact solution of the Euler equations for the asymptotic pancake evolution. This solution combines a shear flow aligned with an asymmetric straining flow, and is characterized by a single asymmetry parameter and an arbitrary transversal vorticity profile. The analysis is based on detailed comparison with numerical simulations performed using a pseudospectral method in anisotropic grids of up to $972\times 2048\times 4096$ .
Aim . To study the combined effect of cardiovascular risk factors and genetic markers that encode the proteins of the main components of neurophysiological systems (renin-angiotensin-aldosterone, sympathetic-adrenal systems, endothelial dysfunction) on the development of arterial hypertension among the indigenous and non-indigenous population of Mountain Shoriya. Material and methods . We performed a clinical and epidemiological study of the compactly settled population in the remote areas of Mountain Shoriya. This region of middle mountains is situated in the south of Western Siberia. We examined 1409 subjects (901 subjects – the representatives of indigenous nationality [the Shors], 508 subjects – representatives of non-indigenous nationality [90% among them were the representatives of the European ethnicity]). Hypertension was diagnosed according to the National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). All patients underwent clinical, laboratory and instrumental investigation. Polymorphisms of genes ACE (I/D, rs 4340), А GT (c.803T>C, rs699), AGTR1 ( А 1166 С , rs5186), ADRB1 ( с .145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs 28365031), MTHFR (c.677 С > Т , Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) were tested using polymerase chain reaction. Results . Cardiovascular risk factors associated with hypertension in cohort of Shorians: hypercholesterolemia [Odds Ratio (OR) 1.54, low density lipoproteinemia (OR 1.48), violation of carbohydrate metabolism (OR 1.53), obesity (OR 2.25), including its abdominal type (OR 1.53), the family anamnesis of early cardiovascular diseases (OR 1.88)] and rs4340 polymorphisms of the ACE gene (OR 4.39), rs5186 of the AGTR1 gene (OR 10.02); in the cohort of the non-indigenous ethnos – hypercholesterolemia (OR 1.87), hypertriglyceridemia (OR 1.87), obesity (OR 2.75), abdominal obesity (OR 2.73), family anamnesis of early cardiovascular diseases (OR 2.48), the polymorphism rs5186 of the AGTR1 gene (OR 26.77). Genotype G/G ADRB1 gene was characterized by protective effect against hypertension in the Shorians. Conclusion . Evaluation of the complex influence of clinical and genetic factors on the development of hypertension in the population of Mountain Shoriya showed their comparable importance among the indigenous population and the predominance of non-genetic factors among the non-indigenous population.
X-ray photoelectron spectroscopy

Two forms of cobalt in fiberglass materials: dimers of Co2+Td in the subsurface layer and isolated Co2+Oh in the bulk
This paper deals with the production of orthodimuonium (OM) $({\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ atom in triplet state) in collisions of high-energy electrons with nuclei or atoms. This reaction was previously studied by Holvik and Olsen [Phys. Rev. D 35, 2124 (1987)] on the basis of a bremsstrahlung mechanism where OM is produced by only one virtual photon. In the present paper, we consider a competing three-photon mechanism where the production of OM results from the collision of a photon generated by the electron with two photons emitted by the nucleus. We derive the corresponding energy spectrum and production rate of OM and show that the three-photon mechanism is the dominant one for a heavy atom target.
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. MAIN OUTCOME MEASURES: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.

Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
All previous data on distribution of Megachilidae in this region are summarized and critically discussed.

An annotated list of 53 species of megachilid bees of the forest-steppe and steppe zones of the West Siberian Plain to the eastwards of Irtysh River is given. New data on distribution of megachilid bees in the different administrative regions of the West Siberian Plain are given also.

Coelioxys echinatus Förster, 1853, Megachile pilidens Alfken, 1924 and Pseudoanthidium tenellum (Mocsáry, 1881) are recorded from the Asian part of Russia for the first time. Megachile melanopyga Costa, 1863 is new to the fauna of Kazakhstan. Eoanthidium clypeare (Morawitz, 1874) and Lithurgus chrysurus Fonscolombe, 1834 are excluded from the fauna of West Siberia.
The teaching of mathematics should reflect the global trends in the development of mathematical and pedagogical scientific thought.

The authors develop guidelines for studying mathematics in the 1st grade based on the Federal State Educational Standard. Thus, the structure and the form of the textbook content are described by chapter. The theoretical part should allow students to complete screening questions, univariate and multivariate tests, problems, and exercises. Each chapter of the developed textbook is divided into paragraphs, and each paragraph is divided into items. One item of theoretical material contains either a new idea to study or a set of interrelated concepts that define a new idea. According to this, it is possible to form mathematical knowledge trajectories. So, there are broad opportunities to transform knowledge elements into multimedia forms, including presentations, videos, test modules, and other newly emerging means of representation and visualization, using the achievements of artificial intelligence.

It is possible to define main themes such as natural numbers counting, acquaintance with geometric shapes, comparison of objects in the value and quantity, acquaintance with a squared paper and measurement standards, the study of objects position, the sets consideration, introduction to the algorithm concept can. The authors’ conceptual directions of teaching mathematics in the 1st grade provide the foundation for mathematical education in general education schools for all the years of study.
Recently, the wide discussion about Higgs-factory design again returns to problem of high energy polarized electrons and positrons. It’s good known the radiative beam polarization at LEP-collider. It was obtained after spin resonance suppression at [Formula: see text] pick, but didn’t appear at energies above 70 GeV due to an enhancement of unavoidable depolarization effects. We examine in this paper various ideas for radiative polarization at TLEP/FCC-ee and formulate some estimates for the polarization buildup time and the asymptotic polarization. Using wigglers, a useful degree of polarization (for energy calibration), with a time constant of about 1 h, may be possible up to the threshold of W pair production. At higher energies such as the threshold of Higgs production, attaining a useful level of polarization may be difficult in a planar ring. With Siberian Snakes, wigglers and some imagination, polarization of reasonable magnitude, with a reasonable time constant (of not more than about 1 h), may be achievable at very high energies.
A stress-strain state and a time duration up to fracture are calculated with allowance for two-stage behavior of a rotating disk under creep conditions. The duration of the stages is investigated depending on the choice of the version of the creep kinetic theory and the geometric dimensions of the disk. The first stage is the accumulation of damage and the beginning of fracture in some area of the body, where the accumulated damage reaches a critical value. The second stage is the spread of the fracture front and the complete destruction of the body. A calculation method has been developed which reduces the solution of the unsteady-state creep problem to the solution of an analogous steady-state problem.
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application.

The first water‐soluble photoluminescent octahedral tungsten cluster [{W 6 I 8 }(DMSO) 6 ](NO 3 ) 4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue.

Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.
An infinite permutation is a linear ordering of the set of non-negative integers. Generally, the properties of infinite permutations analogous to those of infinite words show some resemblances and some differences between permutations and words. In this paper, we define maximal pattern complexity for infinite permutations and show that this complexity function is ultimately constant if and only if the permutation is ultimately periodic. Then we characterize the non-periodic permutations of minimal complexity (equal to n) and find that they all are constructed with the use of Sturmian words.
Caseins are major milk proteins that have an evolutionarily conserved role in nutrition. Sequence variations in the casein genes affect milk composition in livestock species. Regulatory elements of the casein genes could be used to direct the expression of desired transgenes into the milk of transgenic animals. Dozens of casein alleles have been identified for goats, cows, sheep, camels and horses, and these sequence variants are associated with altered gene expression and milk protein content. Most of the known mutations affecting casein genes' expression are located in the promoter and 3'-untranslated regions.

We performed pronuclear microinjections with Cas9 mRNA and sgRNA against the first coding exon of the mouse Csn1s1 gene to introduce random mutations in the α-casein (Csn1s1) signal peptide sequence at the beginning of the mouse gene. Sanger sequencing of the founder mice identified 40 mutations. As expected, mutations clustered around the sgRNA cut site (3 bp from PAM). Most of the mutations represented small deletions (1-10 bp), but we detected several larger deletions as well (100-300 bp).

Functionally most mutations led to gene knockout due to a frameshift or a start codon loss. Some of the mutations represented in-frame indels in the first coding exon. Of these, we describe a novel hypomorphic Csn1s1 (Csn1s1c.4-5insTCC) allele. We measured Csn1s1 protein levels and confirmed that the mutation has a negative effect on milk composition, which shows a 50 % reduction in gene expression and a 40-80 % decrease in Csn1s1 protein amount, compared to the wild-type allele. We assumed that mutation affected transcript stability or splicing by an unknown mechanism. This mutation can potentially serve as a genetic marker for low Csn1s1 expression.
The evolution of unsteady gravitational-capillary convection in a layer of ethyl alcohol with a free surface after sudden electric heating of one of the vertical walls of a rectangular cavity was investigated numerically. The effect of the incoming flow of hot liquid on the time evolution of the temperature field on the opposite thin metal wall of the cavity was investigated. The calculations were carried out by the finite element method in the conjugate two-dimensional formulation with the Prandtl number Pr = 16, and the range of Grashof numbers determined by the heat flux density, 33·10 3 ≤ Gr ≤ 28·10 6 . It is shown that the maximum local temperature gradients occur on the wall near the liquid-gas interface.
The paper presents the results of an experimental investigation of supersonic flow around a solid cylinder with a gas-permeable porous insert on its front end and of supersonic flow around a hollow cylinder with internal porous inserts in the presence of heating of the porous material.

The experiments were performed in a supersonic wind tunnel with Mach number 4.85 and 7 with porous inserts of cellular-porous nickel. The results of measurements on the filtration stand of the air filtration rate through the cellular-porous nickel when it is heated are also shown. For a number of experiments, numerical modeling based on the skeletal model of a cellular-porous material was carried out.
This article develops an optimization neoliberal scenario 1 and a socially-oriented scenario 2 of capitalist reproduction based on US statistics for 2020-40. Scenario 1 preserves the socio-economic structure that generated the systemic, structural, and cyclical crisis of capitalism; it assumes a regular repetition of overproduction and paroxysms.

The transforming social relations in the direction of tightening the workers' control over production and the primary distribution of national income take place in scenario 2. Comparison of these pioneer scenarios with the projections by the Congressional Budget Office in the USA for 2020-2030 reveals the underestimation by the latter of the depth and duration of the epoch-making corona-crisis, which owes its name to the Covid-19 pandemic.

The necessity for Russia of revival of the ideology of socialism, understood as the first phase of communism, is substantiated.