Hengzongshu/ArticleAgent huggingface dataset:
Identified significant changes in the intestinal microbiome in patients with inflammatory bowel disease (IBD), serve as the reason for therapeutic interventions in order to correct it. Faecal microbiota transplantation (TFM) is an effective treatment for recurrent or refractory Clostridium difficile infections, including in patients with inflammatory bowel diseases receiving immunosuppressive and anticytokine therapy.The results of studying the effectiveness of TFM using a filtered aqueous suspension of donors feces in the correction of intestinal microbiocenosis in patients with recurrent Clostridial infection (RCT), ulcerative colitis (UC) and irritable bowel syndrome (IBS) are presented. 2 weeks after the introduction of the supernatant, a suspension of fecal microorganism microorganisms in patients evaluated the dynamics of the total content of microorganisms and individual representatives of the intestinal microflora. It was found that the supernatant of an aqueous suspension of donor feces containing microbial exometabolites and other biologically active compounds in the short term has the most pronounced effect on the restoration of normal intestinal microflora only in patients with clostridial infection.
HgTe quantum wells with inverted band ordering at different electron concentrations. optical transitions from zero-mode Landau levels, which split from the edges of electron-like and hole-like bands.

far-infrared magnetospectroscopy of HgTe quantum wells. electron concentration varied by persistent photoconductivity effect.

electron-electron interactions also have a significant impact on the usual behavior of the optical transitions from zero mode Landau levels, in addition to the already well-documented crystalline and interface asymmetries.
As in earlier works [K. L. Ivanov, A. V. Yurkovskaya, and H.-M. Vieth, J. Chem. Phys. 129, 234513 (2008)10.1063/1.3040272; S. E. Korchak, K. L. Ivanov, A. V. Yurkovskaya, and H.-M. Vieth, J. Chem. Phys. 133, 194502 (2010)10.1063/1.3495988], spin-spin interactions have a pronounced effect on the relaxivity tending to equalize the longitudinal relaxation times once the spins become strongly coupled at a sufficiently low magnetic field.

Effects of spin-spin interactions on the nuclear magnetic relaxation dispersion (NMRD) of protons were studied in a situation where spin ½ hetero-nuclei are present in the molecule. In addition, we have found influence of 19F nuclei on the proton NMRD, although in the whole field range, studied protons and fluorine spins were only weakly coupled.

In particular, pronounced features in the proton NMRD were found; but each feature was predominantly observed only for particular spin states of the hetero-nuclei. The features are explained theoretically; it is shown that hetero-nuclei can affect the proton NMRD even in the limit of weak coupling when (i) protons are coupled strongly and (ii) have spin-spin interactions of different strengths with the hetero-nuclei. We also show that by choosing the proper magnetic field strength, one can selectively transfer proton spin magnetization between spectral components of choice.
Introduction. Post-transcriptional mechanisms play a crucial role in the biological course and clinical manifestations of papillary thyroid cancer (PTC). Recent studies show that an increased content of oncogenic or reduced content of oncosuppressive microRNAs increases the aggressiveness of the tumor and correlates with an unfavorable prognosis of treatment, which allows them to be used in personalizing the treatment tactics of patients with PTC. The study objective is to compare the level of expression of 12 PTC-specific microRNAs and the frequency of V600E mutation of the BRAF gene in patients with different risk of relapse. Materials and methods. The study included 175 patients with PTC. For quantitative analysis of microRNA expression, a reverse transcription reaction followed by a real-time polymerase chain reaction in formalin-fixed paraffin blocks was used. Correlations between 12 microRNA expression and BRAF mutation with different clinical and anatomical features of PTC the risk of relapse according to the American Thyroid Association Risk Stratification System (2009) were analyzed. Results. We demonstrated that miR-146b, miR-221, miR-144, miR-451a, and miR-7 expression correlated with features such as extrathyroid tumor growth, larger size, multifocus, lymph node metastasis, and the presence of distant metastases of the PTC. Most importantly, miR-221, miR-144, miR-451a, and miR-7 expression correlated with risk levels, suggesting their potential significance in stratifying the risk of relapsing PTC. The dependence of the clinical behavior of PTC on the BRAF mutation has not been established. Conclusion. The result of the study will contribute to the individual choice of preoperative treatment tactics for patients with PTC.
It is shown that the rate of corrections to the hydrogen atom and harmonic oscillator energy levels due to the profound quantum gravitational effect of space–time dimension running/reduction coincides well with those obtained by means of minimum-length-deformed quantum mechanics. The rate of corrections is pretty much the same within the accuracy with which we can judge the quantum gravitational corrections at all. Such a convergence of results makes the concept of space–time dimension running more appreciable. As a remarkable distinction, the energy shift due to dimension reduction has the opposite sign as compared with the correction obtained by means of minimum-length-modified quantum mechanics. Therefore, the sign of total quantum gravitational correction remains somewhat obscure.
Objective: to determine the optimal method for long-term wet storage of donor material (50 days after collection), with maximum ability to preserve the original mechanical characteristics. Materials and methods. Porcine aortic wall fragments were used as objects of study. Half of the original material underwent detergent-based decellularization. The entire material (native and processed) was placed for 50 days in biocidal solutions: complex alcohol solution; ethanol and glycerol mixture; antibiotics mixture. Then the tests for mechanical strength of native and decellularized samples were carried out by the method of uniaxial longitudinal and circumferential stress. Results. Storage of native material in all media resulted in a significant increase in tensile strength. In the «complex alcohol solution», «ethanol and glycerol mixture», and «antibiotic mixture» group, tensile strength increased by 1.38-, 1.72- and 1.62-fold compared to the native control in circumferential tension. Also, in the «complex alcohol solution» group, the decellularized material was 1.57-fold stronger than the native in circumferential tension. In the «antibiotic mixture» group, the decellularized material was 1.33-fold less strong than the native in longitudinal tension. According to elongation to rupture data, significantly greater plasticity was noted in the «ethanol-glycerol» storage group for the decellularized aortic wall compared to the control group (1.5-fold). Young’s modulus did not reliably differ from those of control in all experimental groups regardless of the stress direction. Notably, decellularized specimens clearly tended to be stiffer under circumferential stress. Conclusion. Detergent-based decellularization of the porcine aortic wall and subsequent storage of these samples in our chosen experimental solutions for 50 days does not significantly affect the elastic properties of the material. Our proposed treatment methods partially increase the stiffness of the material after storage in alcohol-containing solutions.
The specific organ placenta is much more than a filter: it is an organ that protects, feeds and regulates the growth of the embryo. Affinity chromatography, ELISA, SDS–PAGE and matrix-assisted laser desorption ionization mass spectrometry were used. Using 10 intact human placentas deprived of blood, a quantitative analysis of average relative content [% of total immunoglobulins (Igs)] was carried out for the first time: (92.7), IgA (2.4), IgM (2.5), kappa-antibodies (51.4), lambda-antibodies (48.6), IgG1 (47.0), IgG2 (39.5), IgG3 (8.8) and IgG4 (4.3). It was shown for the first time that placenta contains sIgA (2.5%). In the classic paradigm, Igs represent products of clonal B-cell populations, each producing antibodies recognizing a single antigen. There is a common belief that IgGs in mammalian biological fluids are monovalent molecules having stable structures and two identical antigen-binding sites. However, similarly to human milk Igs, placenta antibodies undergo extensive half-molecule exchange and the IgG pool consists of 43.5±15.0% kappa-kappa-IgGs and 41.6±17.0% lambda-lambda-IgGs, while 15.0±4.0% of the IgGs contained both kappa- and lambda-light chains. Kappa-kappa-IgGs and lambda-lambda-IgGs contained, respectively (%): IgG1 (47.7 and 34.4), IgG2 (36.3 and 44.5), IgG3 (7.4 and 11.8) and IgG4 (7.5 and 9.1), while chimeric kappa-lambda-IgGs consisted of (%): 43.5 IgG1, 41.0 IgG2, 5.6 IgG3 and 7.9 IgG4. Our data are indicative of the possibility of half-molecule exchange between placenta IgGs of various subclasses, raised against different antigens, which explains a very well-known polyspecificity and cross-reactivity of different human IgGs.
The Chair of Physics and Technology of the Physics Department trains specialists in the field of software and hardware for physical experiments, storage, and processing of information. The program of the courses involves the study of programming methods, information technologies and hardware for experimental installations in addition to fundamental education in physics and mathematics, which all students of the physics department of NSU receive. The graduates of the chair are specialists in the field of information technology with universal general physical training.
bulk ferromagnetic doping of topological insulators

submonolayer deposition of a ferromagnetic metal on BiSbTeSe2 topological insulator, using cobalt and manganese as ferromagnets

energy gap was revealed in the Dirac cone of the topological insulator, such way of energy gap opening is novel
Hypersonic boundary layer stability and transition were studied experimentally for the test cases of 7 deg half-angle sharp and blunted cones. The experiments were performed for M=6. Wall pressure pulsations were recorded synchronously with high speed Schlieren visualization. The combined data processing algorithm for coupling of unsteady pressure sensors with high-speed Schlieren images is proposed. Analysis of the wall pressure pulsations evolution reveals that the turbulent spot may arise in different ways. It was found that for the blunted model the role of the second mode in origination of the turbulent spot is more evident.
Do individual differences in personality traits become more or less pronounced over childhood and adolescence? The present research examined age differences in the variance of a range of personality traits, using parent reports of two large samples of children from predominantly the USA and Russia, respectively. Results indicate (i) that individual differences in most traits tend to increase with age from early childhood into early adolescence and then plateau, (ii) that this general pattern of greater personality variance at older childhood age is consistent across the two countries, and (iii) that this pattern is not an artefact of age differences in means or floor/ceiling effects. These findings are consistent with several (noncontradictory) developmental mechanisms, including youths’ expanding behavioural capacities and person–environment transactions (corresponsive principle). However, these mechanisms may predominantly characterize periods before adolescence, or they may be offset by countervailing processes, such as socialization pressure towards a mature personality profile, in late adolescence and adulthood. Finally, the findings also suggest that interpreting age trajectories in mean trait scores as pertaining to age differences in a typical person may sometimes be misleading. Investigating variance should become an integral part of studying personality development. Copyright © 2017 European Association of Personality Psychology
We performed a multicenter, double-blind, placebo-controlled, phase II clinical trial of human dsDNA-based preparation Panagen in a tablet form. In total, 80 female patients with stage II-IV breast cancer were recruited.

Patients received three consecutive FAC (5-fluorouracil, doxorubicin and cyclophosphamide) or AC (doxorubicin and cyclophosphamide) adjuvant chemotherapies (3 weeks per course) and 6 tablets of 5 mg Panagen or placebo daily (one tablet every 2-3 hours, 30 mg/day) for 18 days during each chemotherapy course. Statistical analysis was performed using Statistica 6.0 software, and non-parametric analyses, namely Wilcoxon-Mann-Whitney and paired Wilcoxon tests. To describe the results, the following parameters were used: number of observations (n), median, interquartile range, and minimum-maximum range.

Panagen displayed pronounced leukostimulatory and leukoprotective effects when combined with chemotherapy. In an ancillary protocol, anticancer effects of a tablet form of Panagen were analyzed. We show that Panagen helps maintain the pre-therapeutic activity level of innate antitumor immunity and induces formation of a peripheral pool of cytotoxic CD8+ perforin + T-cells. Our 3-year follow-up analysis demonstrates that 24% of patients who received Panagen relapsed or died after the therapy, as compared to 45% in the placebo cohort.The data collected in this trial set Panagen as a multi-faceted "all-in-one" medicine that is capable of simultaneously sustaining hematopoiesis, sparing the innate immune cells from adverse effects of three consecutive rounds of chemotherapy and boosting individual adaptive immunity. Its unique feature is that it is delivered via gastrointestinal tract and acts through the lymphoid system of intestinal mucosa. Taken together, maintenance of the initial levels of innate immunity, development of adaptive cytotoxic immune response and significantly reduced incidence of relapses 3 years after the therapy argue for the anticancer activity of Panagen.ClinicalTrials.gov NCT02115984 from 04/07/2014.
Altai collision system of Hercynides was formed in Late Paleozoic as a result of oblique collision of Siberian continent and Kazakhstan composed terrane [Vladimirov et al., 2003; 2008; Xiao et al., 2010].

At the late stages of its evolution (time interval from 310–300 to 280–270 Ma) the huge different mafic and felsic magmatism occurred at the territory (Fig. 1) [Vladimirov et al., 2008; Khromykh et al., 2011, 2013, 2014, 2016; Kotler et al., 2015; Sokolova et al., 2016].

It is evident about increased thermal gradient in lithosphere and about significant role of mantle and active manifestation of mantle-crust interactions. Some magmatic complexes may be considered as indicators of mantle-crust interaction processes.
Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern genome-editing tools allow researchers to create isogenic cell clones with an identical genetic background providing an adequate "healthy" control for biomedical and pharmacological experiments.

Here, we generated isogenic mutant cell clones with 150 CAG repeats in the first exon of the huntingtin (HTT) gene using the CRISPR/Cas9 system and performed ultrastructural and morphometric analyses of the internal organization of the mutant cells.

Electron microscopy showed that deletion of three CAG triplets or an HTT gene knockout had no significant influence on the cell structure. The insertion of 150 CAG repeats led to substantial changes in quantitative and morphological parameters of mitochondria and increased the association of mitochondria with the smooth and rough endoplasmic reticulum while causing accumulation of small autolysosomes in the cytoplasm. Our data indicate for the first time that expansion of the CAG repeat tract in HTT introduced via the CRISPR/Cas9 technology into a human cell line initiates numerous ultrastructural defects that are typical for Huntington's disease.
The problem of chemical composition below the knee in the cosmic-ray energy spectrum has not yet been solved due to low statistics collected from direct experiments. In the HiSCORE experiment the lateral distribution functions (LDF) of Cherenkov light of EASs with energy greater than hundreds of TeV can be measured in detail for millions of individual events. A full steepness of LDF is sensitive to the depth of shower maximum and as a result to primary particle type. In this paper, we developed a parametric method of separation between heavy and light groups of nuclei using the ’knee-like’ approximation of LDF and taking into account measurement uncertainty.
was previously thought, to E. hydruntinus or true horses but represents a separate monophyletic group of equids (Orlando et al., 2009). These equids were widespread in the first half of the Pleistocene from Western Europe through eastern Siberia and Alaska (Eisenmann et al., 2008).

On the basis of skeletal remains from the cave a new species was described Equus ovodovi Eisenmann, Vasiliev, 2011(Eisenmann &Vasiliev, 2011). Radiocarbon age of E. ovodovi bones from Proskuriakova Cave corresponds to 42.4-45.7 kyr BP. Detailed examination of tooth and skeletal morphology of the new species showed that E. ovodovi belongs to the subgenus Sussemionus, supposedly extinct in the Middle Pleistocene (Eisenmann, 2010).

The discovery of E. ovodovi in Khakassia suggests that sussemiones survived in western Siberia until the end of the Late Pleistocene.
We observe the phonon-drag voltage oscillations correlating with the resistance oscillations under microwave irradiation in a two-dimensional electron gas in perpendicular magnetic field.

This phenomenon is explained by the influence of dissipative resistivity modified by microwaves on the phonon-drag voltage perpendicular to the phonon flux.

When the lowest-order resistance minima evolve into zero-resistance states, the phonon-drag voltage demonstrates sharp features suggesting that current domains associated with these states can exist in the absence of external dc driving.
The intermediates formed upon the interaction of methane with Cu-modified ZSM-5 zeolites (Cu/H-ZSM-5) have been analyzed with solid-state NMR spectroscopy and DFT methods. Methane activation by Cu/H-ZSM-5 zeolites gives rise to three distinct surface methoxy-like species (−O–CH3) detected by 13C MAS NMR spectroscopy with specific chemical shifts in the range of 53–63 ppm. DFT calculations on representative cluster models of different sites potentially present in Cu/H-ZSM-5 have been used to assign these signals to (i) methanol adsorbed on two neighboring Cu sites (Cu–(HOCH3)–Cu, 62.6 ppm), (ii) methanol adsorbed on zeolite Brønsted acid sites (52.9 ppm), and (iii) lattice-bound methoxy groups (Si–O(CH3)–Al, 58.6). The formation of these methoxy-like intermediates depends on the Cu loading and, accordingly, the type of Cu species in the Cu/H-ZSM-5 zeolite. For the sample with low (0.1 wt %) Cu loading containing exclusively mononuclear isolated Cu species, only the intermediates ii and iii have been detected. The Cu-bound intermediate (i) is formed upon methane activation by multinuclear Cu sites featuring Cu–O–Cu bridging moieties present in the materials with relatively higher Cu loading (1.38 wt %). The presented results indicate that methane activation by Cu/H-ZSM-5 can be promoted by both mono- and multinuclear Cu species confined in the zeolite matrix.
Motivation: According to scanning model, 40S ribosomal subunits can either initiate translation at start AUG codon in suboptimal context or miss it and initiate translation at downstream AUG(s), thereby producing several proteins. Functional significance of such a protein translational polymorphism is still unknown. Results: We compared predicted subcellular localizations of annotated Arabidopsis thaliana proteins and their potential N-terminally truncated forms started from the nearest downstream in-frame AUG codons. It was found that localizations of full and N-truncated proteins differ in many cases: 12.2% of N-truncated proteins acquired sorting signals de novo and 5.7% changed their predicted subcellular locations (mitochodria, chloroplast or secretory pathway). It is likely that the in-frame downstream AUGs may be frequently utilized to synthesize proteins possessing new functional properties and such a translational polymorphism may serve as an important source of cellular and organelle proteomes. Availability: Detailed description of arabidopsis mRNAs potentially producing novel functional protein forms is available by request.
Modern astrophysical methods of determination of spins of rotating stellar-mass black hole in close binaries and of supermassive black holes in active galactic nuclei are briefly discussed. Effective spins of coalescing binary black holes derived from LIGO/Virgo gravitational wave observations are specially addressed.

We consider three types of coalescing binaries: double black holes, black hole-neutron star binaries and primordial double black holes. The effective spins of coalescing astrophysical binary black holes and black holes with neutron stars are calculated for two plausible models of black hole formations from stellar core collapses (without or with additional fallback from the stellar envelope) taking into account the stellar metallicity and star formation rate evolution in the Universe.

The calculated distributions do not contradict the reported LIGO/Virgo observations. The effective spins of primordial coalescing stellar-mass black holes can reach a few per cent due to accretion spin-up in the cold external medium.
A search is presented for the decay Υ(1S)→γA0, A0→c¯c, where A0 is a candidate for the CP-odd Higgs boson of the next-to-minimal supersymmetric standard model.

The search is based on data collected with the BABAR detector at the Υ(2S) resonance. A sample of Υ(1S) mesons is selected via the decay Υ(2S)→π+π−Υ(1S). The A0→c¯c decay is identified through the reconstruction of hadronic D0, D+, and D∗(2010)+ meson decays.

No significant signal is observed. The measured 90% confidence-level upper limits on the product branching fraction B(Υ(1S)→γA0)×B(A0→c¯c) range from 7.4×10−5 to 2.4×10−3 for A0 masses from 4.00 to 8.95 GeV/c2 and 9.10 to 9.25 GeV/c2, where the region between 8.95 and 9.10 GeV/c2 is excluded because of background from Υ(2S)→γχbJ(1P), χbJ(1P)→γΥ(1S) decays.
A measurement of the rate for the "wrong-sign" decay D0→K+π−π+π− relative to that for the "right-sign" decay D0→K−π+π+π− is presented.

Using 791 fb−1 of data collected with the Belle detector, we obtain a branching fraction ratio of Rws=[0.324±0.008(stat)±0.007(sys)]%.

Multiplying this ratio by the world average value for the branching fraction B(D0→K−π+π+π−) gives a branching fraction B(D0→K+π−π+π−)=(2.61±0.06−0.08+0.09)×10−4.