Hengzongshu/ArticleAgent huggingface dataset:
CD150 (IPO3/SLAM) belongs to the SLAM family of receptors and serves as a major entry receptor for measles virus. CD150 is expressed on normal and malignant cells of the immune system. However, little is known about its expression outside the hematopoietic system, especially tumors of the central nervous system (CNS). Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others. CD150 was detected in the cytoplasm, but not on the cell surface of glioma cell lines, and it was colocalized with the endoplasmic reticulum and Golgi complex markers. In addition to the full length mRNA of the mCD150 splice isoform, in glioma cells we found a highly expressed novel CD150 transcript (nCD150), containing an 83 bp insert. The insert is derived from a previously unrecognized exon designated Cyt-new, which is located 510 bp downstream of the transmembrane region exon, and is a specific feature of primate SLAMF1. Both mCD150 and nCD150 cDNA variants did not contain any mutations and had the leader sequence. The nCD150 transcript was also detected in normal and malignant B lymphocytes, primary T cells, dendritic cells and macrophages; however, in glioma cells nCD150 was found to be the predominant CD150 isoform. Similarly to mCD150, cell surface expression of nCD150 allows wild type measles virus entry to the cell. Our data indicate that CD150 expression in CNS tumors can be considered a new diagnostic marker and potential target for novel therapeutic approaches.
We study particle production in infrared-modified gravitational theories in the contemporary universe.

It is shown that in astronomical systems with rising mass density, the curvature scalar may oscillate with very high frequency. These oscillations lead to efficient particle production and in an interesting range of model parameters could be a source of energetic cosmic rays.

This effect either excludes some models of modified gravity or suggests a new mechanism of cosmic ray production.
Purpose To determine the most effective methods of informing people about the primary prevention of hypertension using a social media website.

Materials and methods It was a randomized, prospective, two-stage study conducted on a social media website ( i . e ., the Instagram platform). At Stage 1 Save Your Heart online school was announced, and 945 applicants were registered for the training. The online training programme included the following modules: Risk Factors for Cardiovascular Diseases (CVDs), Heart-Healthy Diet, Cholesterol. What a Patient Needs to Know, Physical Activity for the Prevention of CVDs, Overweight and Obesity, Smoking as a Risk Factor for CVDs, Hypertension: Diagnosis, Hypertension: Treatment, Myocardial Infarction: Diagnosis and Treatment. At Stage 2 a total of 125 participants were randomly selected and assigned into one of the four training groups depending on the training mode, i . e . text posts of up to 4.000 characters, short video clips of up to 5 minutes, text posts followed by video clips or video clips followed by text posts in Group 1 ( n =31), Group 2 ( n =31), Group 3 ( n =33) and Group 4 ( n =30), respectively. Before and after training respondents in all the four groups completed the Heart Disease Knowledge Questionnaire (HDKQ).

Conclusions In all the 4 groups there was a tendency to increase in the number of correct responses after training, but among the training modes the most effective method of informing people about the primary prevention of hypertension using a social media website corresponded to the following sequence: a video clip of up to 5 minutes followed by a text post of up to 4,000 characters. Participants in Group 3 who received the material in the form of text posts followed by video clips gave the lowest number of correct responses for HDKQ statements after training. The results of this study can be used to design online training programmes for the primary prevention of hypertension.
Self-assembly reactions of Na2WO4, SeO2/SeO32–, and [Mo2O2(μ-S)2(H2O)6]2+ give, depending on the pH value, two new large polyoxometalate complexes: i.e., [(γ-Se2W14O52)3(Mo2O2(μ-S)2(H2O)2)6]24– (1) isolated at pH 3.5 and [(γ-Se2W14O52)4(WO3(H2O))8(W2O5)2(W4O12)2(Mo2O2(μ-S)2(H2O)2)4(Mo2O2(μ-S)2(SeO3))4]36– (2) isolated at pH 2. Both compounds were characterized in the solid state by single-crystal X-ray diffraction, EDX, elemental analysis, TGA, and FT-IR and in solution by ESI-MS and NMR.
To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic, which implements the smoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.
T0 and T1 transgenic tobacco and alfalfa plants expressing the gene coding for β-interferon driven by 1′ - 2′ promoter are assayed for resistance respectively to TMV and AIMV. Marked delay of symptoms development of virus infection is detected in both transgenic tobacco and alfalfa plants These studies indicate that interferon accumulation in transgenic plants alters their reaction to virus infection. The influence of environmental conditions on transgene expression (transgenic plants tolerance to virus infection) is discussed in connection with the bidirectional 1′ - 2′ promoter.
When a fragment of a Drosophila imaginal disc is cultured in growth permissive conditions, it either regenerates the missing structures or duplicates the pattern present in the fragment. This kind of pattern regulation is known to be epimorphic, i.e. the new pattern is generated by proliferation in a specialized tissue called the blastema. Pattern regulation is accompanied by the healing of the cut surfaces restoring the continuous epithelia. Wound healing has been considered to be the inductive signal to commence regenerative cell divisions. Although the general outlines of the proliferation dynamics in a regenerating imaginal disc blastema have been well studied, little is known about the mechanisms driving cells into the regenerative cell cycles. In this study, we have investigated the role of Jun N-terminal Kinase (JNK) signaling in the wound healing and regeneration of a Drosophila wing imaginal disc. By utilizing in vivo and in vitro culturing of incised and fragmented discs, we have been able to visualize the dynamics in cellular architecture and gene expression involved in the healing and regeneration process. Our results directly show that homotypic wound healing is not a prerequisite for regenerative cell divisions. We also show that JNK signaling participates in imaginal disc wound healing and is regulated by the physical dynamics of the process, as well as in recruiting cells into the regenerative cell cycles. A model describing the determination of blastema size is discussed.
Electron-energy-loss spectroscopy (EELS) is a widely used experimental technique for characterization of nanoparticles, being an extension of a standard electron microscopy. In EELS a particle under study is exposed to an electron beam and the loss of electron kinetic energy is measured after the interaction, varying the transverse position of the beam. This technique is particularly suitable for plasmonic nanoparticles, which exhibit unique optical properties caused by localized surface plasmon resonances (LSPRs). EELS excites full set of LSPRs and allows mapping them with unprecedented spatial resolution of down to 1 nm. The discrete dipole approximation (DDA) is a numerically exact method for simulating interaction of electromagnetic waves with particles of arbitrary shape and internal structure. It is based on volume-integral equation (VIE) in the frequency domain. In this work we extend the DDA to simulate EELS. We base all theoretical derivations on the VIE, in particular, the electric field of a moving electron is given as a line integral of the Green's tensor. Although the final expressions agree with classical textbooks, our approach allows us to employ the energy-budget considerations in the frequency domain. First, this framework leads to an expression for energy losses of electron moving faster than the speed of light in non-absorbing homogeneous medium (Cherenkov radiation), that is in agreement with the classical result (Frank-Tamm formula). Second, it leads to rigorous and general expressions for additional losses in the presence of a scatterer. These expressions are given as integrals over the volume of the scatterer (very convenient for the DDA) and are valid not only for the case of vacuum, but for arbitrary (even absorbing) host medium. We are working on implementing them in the open-source software package ADDA.
N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment.

The article presents for the first time data on the frequency of two important 'slow' variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia. The aim of this study was to identify the frequencies of these variants and compare them with frequencies in other ethnic populations.NAT2*5 (T341C) genotyping revealed frequencies of 28,0% and 38,6% for Tundra and Forest Nenets, respectively. The frequencies of NAT2*7 (G857A) variant were 9,8% and 8,2% for Tundra and Forest Nenets, respectively.

Polymorphic variants frequencies for Nenets are intermediate between those in populations of Europeans and Asians. These results can probably be explained by the presence of both European and Asian components in Nenets gene pools.The results of this study expand the knowledge of NAT2 polymorphism in world populations. These data may also help assess the genetic predisposition of Nenets to multifactorial diseases associated with polymorphism in the NAT2 gene and, in general, contribute to the development of personalized medicine in reference to native people of Siberia.
This article describes a fundamentally new method for obtaining gas hydrates, based on self-organization in a closed working section of the cyclic boiling-condensation process of the gas-hydrate generator. A special feature of this method is the high rate of hydrate formation at low energy costs and, as a consequence, the expected efficiency of new technologies built on its basis over analogues. A series of experiments was performed, which shows the effect of the water level on the work site on the hydrate formation process.
T0 and T1 transgenic tobacco and alfalfa plants expressing the gene coding for β-interferon driven by 1′ - 2′ promoter are assayed for resistance respectively to TMV and AIMV.

Marked delay of symptoms development of virus infection is detected in both transgenic tobacco and alfalfa plants

These studies indicate that interferon accumulation in transgenic plants alters their reaction to virus infection. The influence of environmental conditions on transgene expression (transgenic plants tolerance to virus infection) is discussed in connection with the bidirectional 1′ - 2′ promoter.
Using inclusive decays of , a precise determination of the number of events collected with the BESIII detector was performed. For the two data sets taken in 2009 and 2012, the numbers of events were recalculated to be and , respectively; these numbers are in good agreement with the previous measurements.

For the sample taken in 2017–2019, the number of events was determined to be .

The total number of events collected with the BESIII detector was determined to be , where the uncertainty is dominated by systematic effects, and the statistical uncertainty is negligible.
In this paper, we study the class of Jordan dialgebras (also called quasi-Jordan algebras). We develop an approach for reducing problems on dialgebras to the case of ordinary algebras. It is shown that straightforward generalizations of the classical Cohn's, Shirshov's, and Macdonald's Theorems do not hold for dialgebras. However, we prove dialgebraic analogues of these statements. Also, we study multilinear special identities which hold in all special Jordan algebras and do not hold in all Jordan algebras. We find a natural correspondence between special identities for ordinary algebras and dialgebras.
The ATLAS experiment at the Large Hadron Collider (LHC) employs a trigger system consisting of a first-level hardware trigger (L1) and a software-based high-level trigger. The L1 muon trigger system selects muon candidates, assigns them to the correct LHC bunch crossing and classifies them into one of six transverse-momentum threshold classes. The L1 muon trigger system uses resistive-plate chambers (RPCs) to generate the muon-induced trigger signals in the central (barrel) region of the ATLAS detector. The ATLAS RPCs are arranged in six concentric layers and operate in a toroidal magnetic field with a bending power of 1.5 to 5.5 Tm. The RPC detector consists of about 3700 gas volumes with a total surface area of more than 4000 m$^2$.

This paper reports on the performance of the RPC detector and L1 muon barrel trigger using 60.8 fb$^{-1}$ of proton-proton collision data recorded by the ATLAS experiment in 2018 at a centre-of-mass energy of 13 TeV. Detector and trigger performance are studied using $Z$ boson decays into a muon pair. Measurements of the RPC detector response, efficiency, and time resolution are reported. Measurements of the L1 muon barrel trigger efficiencies and rates are presented, along with measurements of the properties of the selected sample of muon candidates. Measurements of the RPC currents, counting rates and mean avalanche charge are performed using zero-bias collisions.

Finally, RPC detector response and efficiency are studied at different high voltage and front-end discriminator threshold settings in order to extrapolate detector response to the higher luminosity expected for the High Luminosity LHC.
The decay Z(c)(3900)(+/-) -> omega pi(+/-) is searched for using data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies root s = 4.23 and 4.26 GeV. No significant signal for the Z(c)(3900)(+/-) is found, and upper limits at the 90% confidence level on the Born cross section for the process e(+)e(-) -> Z(c)(3900)(+/-) pi(-/+) -> omega pi(+)pi(-) are determined to be 0.26 and 0.18 pb at root s = 4.23 and 4.26 GeV, respectively.
The topicality of the appeal to the interpretation of a tree-cross mythologeme is caused by the change of the pagan worldview into Christian. The development of ideas about the Christian sign is complex, in one of the approaches to transforming the tree-cross, a part of the overcome ideas about the world as space around the world axis is preserved, i.e. the world tree. The coming era of Christianity inherits this view, and the cross itself appears as a world axis that defines the coordinates of space.

Research methods which are used in this article are as follows: philological analysis of the text and semiotic analysis of texts. The set of communicatively relevant factors that determine the statement, as well as the situational and contextual relevance of the lexical meaning, are taken into account. In turn, the necessary initial amount of communicatively relevant information is obtained on the basis of linguistic methods. In particular, data from an etymological analysis are involved. The research material was provided by the Old English written monuments accessible to the modern researcher. Texts in other Indo-European languages are occasionally referred; they act as a background showing some parallels

The purpose of the article is to show the evolutionary semiotic row, which represents both Christian and pagan symbolism. Initially, the cross appears as a motivated view. Then the terms of the denotative plan appear, devoid of pagan connotations of the tree-cross type. In general, in the evolution of the term continuity is traced, one designation is replaced by another. For some time, the second item copies the functions and forms of the first, replacing it in the subject line. The cross as an object of worship in Christianity replaces the world tree. All new nominations of the cross are associated with the motivation of the world as the center where the altar is installed, which was initially presented in the tradition as a world tree, and then became designated by the cross. The cross, as the main Christian symbol, often appears as made of wood and is identified with the cosmic world tree growing directly into heaven.
Obesity is a major risk factor for developing gallstone disease (GSD). Previous studies have shown that obesity is associated with an elevated Firmicutes/Bacteroidetes ratio in the gut microbiota. These findings suggest that the development of GSD may be related to gut dysbiosis. This review presents and summarizes the recent findings of studies on the gut microbiota in patients with GSD. Most of the studies on the gut microbiota in patients with GSD have shown a significant increase in the phyla Firmicutes (Lactobacillaceae family, genera Clostridium, Ruminococcus, Veillonella, Blautia, Dorea, Anaerostipes, and Oscillospira), Actinobacteria (Bifidobacterium genus), Proteobacteria, Bacteroidetes (genera Bacteroides, Prevotella, and Fusobacterium) and a significant decrease in the phyla Bacteroidetes (family Muribaculaceae, and genera Bacteroides, Prevotella, Alistipes, Paludibacter, Barnesiella), Firmicutes (genera Faecalibacterium, Eubacterium, Lachnospira, and Roseburia), Actinobacteria (Bifidobacterium genus), and Proteobacteria (Desulfovibrio genus). The influence of GSD on microbial diversity is not clear. Some studies report that GSD reduces microbial diversity in the bile, whereas others suggest the increase in microbial diversity in the bile of patients with GSD. The phyla Proteobacteria (especially family Enterobacteriaceae) and Firmicutes (Enterococcus genus) are most commonly detected in the bile of patients with GSD. On the other hand, the composition of bile microbiota in patients with GSD shows considerable inter-individual variability. The impact of GSD on the Firmicutes/Bacteroidetes ratio is unclear and reports are contradictory. For this reason, it should be stated that the results of reviewed studies do not allow for drawing unequivocal conclusions regarding the relationship between GSD and the Firmicutes/Bacteroidetes ratio in the microbiota.
The results of numerical modeling of steel plate laser cutting with nitrogen as assist gas with consideration of heat transfer into a bulk material are presented.

In this work we studied a distribution of absorbed radiation energy inside cut kerf and the difference between CO2 and fiber laser radiation propagation and absorption.

The influence of secondary absorption of reflected from the cut front radiation on stability of melt hydrodynamics is discussed for different laser types.
Duplications and deletions in the human genome Duplications and deletions can lead to variation in copy number for genes and genomic loci among humans. Such variants can reveal evolutionary patterns and have implications for human health. Sudmant et al. examined copy-number variation across 236 individual genomes from 125 human populations. Deletions were under more selection, whereas duplications showed more population-specific structure. Interestingly, Oceanic populations retain large duplications postulated to have originated in an ancient Denisovan lineage. Science , this issue 10.1126/science.aab3761
Gene expression regulation at the transcriptome, genome, cell, and tissue levels is a complex phenomenon demanding the development of bioinformatics tools [...].
We report the final results of a study of the ψ(3770) meson using a data sample collected with the KEDR detector at the VEPP-4M electron–positron collider. The data analysis takes into account interference between the resonant and nonresonant DD¯ production, where the latter is related to the nonresonant part of the energy-dependent form factor FD. The vector dominance approach and several empirical parameterizations have been tried for the nonresonant FDNR(s). Our results for the mass and total width of ψ(3770) areM=3779.2−1.7+1.8−0.7+0.5−0.3+0.3MeV,Γ=24.9−4.0+4.6−0.6+0.5−0.9+0.2MeV, where the first, second and third uncertainties are statistical, systematic and model, respectively. For the electron partial width two possible solutions have been found:(1)Γee=154−58+79−9+17−25+13eV,(2)Γee=414−80+72−26+24−10+90eV. Our statistics are insufficient to prefer one solution to another. The Solution (2) mitigates the problem of non-DD¯ decays but is disfavored by potential models. It is shown that taking into account the resonance–continuum interference in the near-threshold region affects resonance parameters, thus the results presented cannot be directly compared with the corresponding PDG values obtained ignoring this effect.
Breeding programs for purple wheat are underway in many countries but there is a lack of information on the effects of Pp (purple pericarp) genes on agronomic and quality traits in variable environments and along the product chain (grain-flour-bread). This study was based on unique material: two pairs of isogenic lines in a spring wheat cv. Saratovskaya-29 (S29) background differing only in Pp genes and grain color. In 2017, seven experiments were conducted in Kazakhstan, Russia, and Turkey with a focus on genotype and environment interaction and, in 2018, one experiment in Turkey with a focus on grain, flour, and bread quality. The effect of environment was greater compared to genotype for the productivity and quality traits studied. Nevertheless, several important traits, such as grain color and anthocyanin content, are closely controlled by genotype, offering the opportunity for selection. Phenolic content in purple-grained lines was not significantly higher in whole wheat flour than in red-colored lines. However, this trait was significantly higher in bread. For antioxidant activities, no differences between the genotypes were detected in both experiments. Comparison of two sources of Pp genes demonstrated that the lines originating from cv. Purple Feed had substantially improved productivity and quality traits compared to those from cv. Purple.
This paper presents the results of an experimental study of the optical properties of highly resistive monocrystals of potassium titanyl phosphate (KTiOPO4, KTP) in the frequency range of 0.2–1 THz and the temperature range of (−192)–150 °C. The dispersion of the refractive indices is approximated in the form of Sellmeier equations. The results show that the temperature dependence of the Sellmeier coefficients for all three principal optical axes is close to linear and, most likely, does not experience an extremum in the vicinity of the activation temperatures of the cationic conductivity of the KTP crystal at (−73)–(−23) °C. Weak frequency dependence of an optical axis direction angle VZ in the range of 0.2–1 THz is confirmed. However, the change in VZ with temperature is three times higher than reported before.