Hengzongshu/ArticleAgent huggingface dataset:
Numerical models develop with development of computational technique, and this development can include either creation of new models, or modification, improvement of existing ones. Modifications can concern both mathematical part, for example, change of numerical schemes, parameterization of various physical processes, and technical part, for example, adaptation of algorithms for use on other computer systems or parallelization of algorithms. The paper considers the issue of optimization of parallel computations for the ice and ocean model SibCIOM. Optimization consists in constructing a mesh partitioning for which the nodes are evenly distributed across the computational cores and the time spent on exchanges is minimal. The METIS package is used to implement such a mesh partitioning. A conceptual description of the implementation of exchange processes for such partitioning is presented.
We explored functional roles of two H3K9-specific histone methyltransferases of Drosophila melanogaster, SetDB1 (also known as Eggless) and Su(var)3-9.

Using the DamID approach, we generated the binding profile for SetDB1 in Drosophila salivary gland chromosomes, and matched it to the profile of Su(var)3-9. Unlike Su(var)3-9, SetDB1 turned out to be an euchromatic protein that is absent from repeated DNA compartments, and is largely restricted to transcription start sites (TSSs) and 5′ untranslated regions (5′UTRs) of ubiquitously expressed genes. Significant SetDB1 association is also observed at binding sites for the insulator protein CP190. SetDB1 and H3K9 di- and tri-methylated (me2 and me3)-enriched sites tend to display poor overlap. At the same time, SetDB1 has a clear connection with the distribution of H3K27me3 mark. SetDB1 binds outside the domains possessing this modification, and about half of the borders of H3K27me3 domains are decorated by SetDB1 together with actively transcribed genes.

On the basis of poor correlation between the distribution of SetDB1 and H3K9 methylation marks, we speculate that, in somatic cells, SetDB1 may contribute to the methylation of a broader set of chromosomal proteins than just H3K9. In addition, SetDB1 can be expected to play a role in the establishment of chromatin functional domains.
В статье представлен новый метод определения линейных размеров и объема яйца на основе компьютерного анализа фотоизображений.Новый метод апробирован на примере модельного для многих зоологических исследований вида -мухоловки-пеструшки Ficedula hypoleuca.На 67 фотографиях кладок яиц мухоловкипеструшки было определено 216 объектов (изображений яиц), 135 из которых соответствовали критериям достоверности и были подвергнуты дальнейшему анализу.Выявлены и описаны основные проблемы метода, перспективы дальнейшего развития и применения.Разработан свод правил, которым должен следовать фотограф при фотографировании кладок яиц, так как важной частью анализа фотоизображения является наличие качественных фотографий, полученных в максимально схожих условиях.Измеренные с помощью нового метода размеры и объем яиц можно применять для оценки приспособленности и популяционных исследований.При этом минимизируются риски беспокойства птиц и
Practical implementation of digital signal processing for mitigation of transmission impairments in optical communication systems requires reduction of the complexity of the underlying algorithms.

Here, we investigate the application of convolutional neural networks for compensating nonlinear signal distortions in a 3200 km fiber-optic 11x400-Gb/s WDM PDM-16QAM transmission link with a focus on the optimization of the corresponding algorithmic complexity. We propose a design that includes original initialisation of the weights of the layers by a filter predefined through the training a single-layer convolutional neural network. Furthermore, we use an enhanced activation function that takes into account nonlinear interactions between neighbouring symbols. To increase learning efficiency, we apply a layer-wise training scheme followed by joint optimization of all weights applying additional training to all of them together in the large multi-layer network.

We examine application of the proposed convolutional neural network for the nonlinearity compensation using only one sample per symbol and evaluate complexity and performance of the proposed technique.
The proposed article considers the possibilities of various types of expert research on criminal cases of fraud in the field of automobile insurance (CTP, CASCO).

On the example of illustrative cases from the published judicial practice in criminal cases, the features of the appointment of certain types of forensic examinations, their research potential are demonstrated. Clearly shows the wide the possibility of applying special knowledge to improve the effectiveness of detecting and investigating insurance fraud committed by staging and falsifying the circumstances of road accidents.

The prospects for the use of atypical forensic examinations in criminal cases of relevant crimes are shown. The article is recommended not only to employees of investigative departments of law enforcement agencies, judges and experts, but also to a wide range of readers interested in countering fraud and other crimes committed in the insurance industry.
The hyperpolarization of nuclear spins is a game-changing technology that enables hitherto inaccessible applications for magnetic resonance in chemistry and biomedicine. Despite significant advances and discoveries in the past, however, the quest to establish efficient and effective hyperpolarization methods continues. Here, we describe a new method that combines the advantages of direct parahydrogenation, high polarization (P), fast reaction, and low cost with the broad applicability of polarization transfer via proton exchange. We identified the system propargyl alcohol + pH2 → allyl alcohol to yield 1H polarization in excess of P ≈ 13% by using only 50% enriched pH2 at a pressure of ≈1 bar. The polarization was then successfully relayed via proton exchange from allyl alcohol to various target molecules. The polarizations of water and alcohols (as target molecules) approached P ≈ 1% even at high molar concentrations of 100 mM. Lactate, glucose, and pyruvic acid were also polarized, but to a lesser extent. Several potential improvements of the methodology are discussed. Thus, the parahydrogen-induced hyperpolarization relayed via proton exchange (PHIP-X) is a promising approach to polarize numerous molecules which participate in proton exchange and support new applications for magnetic resonance.
At present motor transport is one of the key components of the formation of a long-term policy of sustainable economic development. Analysis of the structure of energy consumption in motor transport is necessary for better understanding of the factors that affect the increase in the share of renewable energy sources in transport and the effectiveness of specific support measures for the transition to vehicles with minimal or no greenhouse gas emissions.

Models of pooled regression, regression with random and fixed effects were built in order to reveal the influence of the chosen factors on the share of renewable energy and electricity in the structure of energy consumption by vehicles.

The results of evaluation for 31 European countries in the 2005-2017 showed that the criterion, which allows identifying groups of countries, is the volume of environmental transport taxes per vehicle unit. Countries with higher taxation volumes has such influencing factors as Corruption Perceptions Index, Energy productivity, Total environmental taxes per capita and Employment in high- and medium-high technology manufacturing sectors and knowledge-intensive service sectors. Consumption in countries with lower tax differentiation is influenced by index of research intensity, Corruption Perceptions Index and Shares of environmental and labour taxes.
Because DNase antibodies are cytotoxic, enter the nucleus and cause DNA fragmentation inducing cell death by apoptosis, they can play an important role in the pathogenesis of different autoimmune pathologies and especially systemic lupus erythematosus (SLE). The interesting goal of catalytic antibodies research is not only to study a possible biological role of such antibodies, but also to develop in future new human and animal therapies that use the advantages offered by abzymes. An immunoglobulin κ light chain library from SLE patients was cloned into a phagemid vector. Phage particles displaying recombinant monoclonal antibody light chains (MLChs) capable of binding DNA were isolated by affinity chromatography on DNA-cellulose. Sixteen of the 46 MLChs efficiently hydrolyzed DNA; one MLCh (approximately 27–28kDa) was expressed in Escherichia coli and purified by metal chelating and gel filtration. MLCh NGK-1 was electrophoretically homogeneous and demonstrated a positive answer with mouse IgGs against light chains of human antibodies after western blotting. SDS-PAGE in a gel containing DNA demonstrated that the MLCh hydrolyzes DNA and is not contaminated by canonical DNases. The DNase MLCh was activated by several metal ions. The protein sequence of the DNase MLCh has homology with mammalian DNases I and shares with them several identical or similar (with the same side chain functionality) important amino acid residues, which are necessary for DNA hydrolysis and binding of Mg2+ and Ca2+ ions. The affinity of DNA for this first example of a MLCh (KM = 0.3 microM) was 150- to 200-fold higher than for human DNase I.
In the present work, a thermodynamic analysis of the interaction between endonuclease VIII (Endo VIII) and model DNA substrates containing damaged nucleotides, such as 5,6-dihydrouridine and 2-hydroxymethyl-3-hydroxytetrahydrofuran (F-site), was performed. The changes in the fluorescence intensity of the 1,3-diaza-2-oxophenoxazine (tC°) residue located in the complementary chain opposite to the specific site were recorded in the course of the enzyme-substrate interaction. The kinetics was analyzed by the stopped-flow method at different temperatures. The changes of standard Gibbs free energy, enthalpy, and entropy of sequential steps of DNA substrate binding, as well as activation enthalpy and entropy for the transition complex formation of the catalytic stage, were calculated. The comparison of the kinetic and thermodynamic data characterizing the conformational transitions of enzyme and DNA in the course of their interaction made it possible to specify the nature of the molecular processes occurring at the stages of substrate binding, recognition of the damaged base, and its removal from DNA.
Some nuclear spin systems support long-lived states, which display greatly extended relaxation times relative to the relaxation time of nuclear spin magnetization. In spin-1/2 pairs, such a long-lived state is given by singlet order, representing the difference of the population of the nuclear singlet state and the mean population of the three triplets. In many cases, the experiments with long-lived singlet order are very time-consuming because of the need to wait for singlet order decay before the experiment can be repeated; otherwise, spin order remaining from a previous measurement may lead to experimental artifacts. Here, we propose techniques for fast and efficient singlet order destruction. These methods exploit coherent singlet-triplet conversion; in some cases, multiple conversion steps are introduced. We demonstrate that singlet order destruction enables a dramatic reduction of the waiting time between consecutive experiments and suggest to use this approach in singlet-state Nuclear Magnetic Resonance (NMR) experiments with nearly equivalent spins.
The mechanism of aerosol formation in coal mines during the operation of a longwall shearer was studied using a diffusion battery, optical counter, and by means of Transmission Electron Microscopy (TEM). The aerosol number concentration was measured to be (2–5) × 105 cm–3. The aerosol size spectrum contained three modes, at about 10, 100, and 1000 nm.

The laboratory studies of organic aerosol formation in a flow coal grinding machine showed that the size spectrum and morphology of aerosol from the grinding machine were close to those in the coal mine. The analysis of gas-phase products in the outflow of the grinding machine showed that along with aerosol formation, gas products such as CO, CO2, CH4, C2H6, H2O are released from coal due to the frictional heat. To demonstrate the explosibility of organic aerosol, the combustion of organic aerosol in the air was studied.

This fact confirms the thesis that the release of frictional heat is the driving force for the formation of organic aerosol. Methane and ethane concentrations in the flow reached 10 and 5 vol. %, respectively. It was shown that the lower explosive limit for organic aerosol is less than 50 g m–3. A conclusion is made that the formation of organic aerosol is to be taken into account when estimating the safety limits in coal mines.
Purpose. Archaeological science has intensively developed in the last few decades. The methodology is being improved, the number of investigated objects is increasing, and archaeological material is accumulating. One of the most important aspects of scientific activity is the integration of the results of work into the scientific community. Results. On March 16–19, 2020, a scientific seminar named “The complexes with flat-bottomed ceramics in the Neolithic of the Urals and Western Siberia: typology, technology, chronology, genesis” was held in Yekaterinburg. More than 50 leading specialists came from the Urals, Western Siberia, Germany and Japan. The set of reports were presented, each presentation was followed by a discussion. The participants had an opportunity to examine the collections of the archaeological sites with flat-bottomed pottery. At the final discussion, a number of serious conclusions were made. They are relevant for the entire region of Northern Eurasia, not only for the Urals and Western Siberia. Conclusion. It has been confirmed that flat-bottomed pottery appeared in Western Siberia and the Urals in the 7th millennium BC. The earliest complexes were discovered in the Baraba forest-steppe and in the Taiga regions in the North of Western Siberia. In local areas, different types of dishes are distinguished, having both similar features and differences. Discussions remain the genesis of morphologically different vessels. Problems of the attitude of complexes of flat-bottomed ceramics to the early and late stages of the Neolithic, the paths and variants of neolithization processes, the spread of ceramic production in a wide area of the region. The current problem of the ratio of Upper Paleolithic, Mesolithic and Early Neolithic formations in the region appears to be relevant. As well as the time of the invention of pottery by man, the fact which radically changed his economy and culture, as well as the physiology of man himself.
Background.Sperm morphology defects are considered to indicate several spermiogenesis anomalies, resulting in decreased men fertility, causing not only poor sperm morphology but also increased DNA fragmentation, chromatin condensation defects, increased oxidative stress. Consequently, detailed assessment of sperm morphological abnormalities in additional to counting percentage of sperm with normal morphology may be useful for andrologists and reproductive biologists. However, a little attention is paid to studying a regional and especially ethnic variability in the incidence of the sperm morphology defects. The aim of this research was to estimate ethnic variability in percentages of the sperm morphology abnormalities in men from general population living in the Siberian region of the Russian Federation.Methods.Male volunteers of Buryat (n=195), Yakut (n=130), and Slavic (n=89) ethnicity from the general population from Ulan-Ude and Yakutsk at least 5 years were enrolled in the study. Percentages of sperm morphological defects (according to the classification provided by the WHO laboratory manual, 2010) are counted after staining native ejaculate smears by Diff-Quick kits. Results.Among sperm defect, amorphous (62.25±12.18%), elongated (10.61±8.62%), pyriform(8.61±9.17%), and vacuolated heads (10.31±6.77%), abnormal acrosome (20.43±12.67%), asymmetrical insertion neck (18.33±6,43%), thick midpiece (6.21±3,41%), bent head (5.94±4,02%) and coiled tail (10.8±6.79%) were most frequent. In comparison with Buryats, Slavs and Yakuts were characterized by the decreased proportion sperm with normal morphology, the increased proportion of pyriform, elongated heads, abnormal acrosome, asymmertical tail insertion, excessive residual cytoplasm and increased teratozoospermia index (TZI). It was shown that impared progressive sperm motility and concentration associated with decreased percentage of sperm with normal morphology and increased proportion most of sperm morphology defects and TZI. However, increasing TZI in men with oligoastenozoospermia compared to men with astenozoospermia was revealed for Buryats only, suggesting ethnic features in the relationships between sperm morphology and concentration.Conclusion.The present study showed significant coordinated ethnic variability in the percentages of several sperm morphological defects in men from the general population located in Eastern Siberia. Damaged spermiogenesis processes underlying sperm head elongation and tail formation is considered to be significant contributors to geographical and ethnic variability of sperm morphology in men from the studied populations.
Experimental studies of photocatalytic oxidation (PCO) of VX-gas simulation substance cysteamine-S-phosphate sodium salt (NaHPO3S–CH2–CH2–NH2, CPSS) at various initial concentrations and pH were undertaken.

PCO byproducts of CPSS include acetate, oxalate and trace amounts of formate ions. The formation rates of acetate and phosphate were equal to the rate of degradation of CPSS. Sulphate was formed more slowly due to stepwise oxidation of reduced sulphur. Amino group, generally transformed to ammonia, was partially oxidised to nitrite and nitrate in alkaline media.

PCO ultimately resulted in complete mineralisation of CPSS. The fastest mineralisation in terms of both TOC degradation and phosphate formation was observed in neutral media. Under neutral media conditions, the PCO rate increased linearly with the CPSS concentration increase. The maximum efficiency by TOC degradation was observed as large as 77 mg per Wh of incident UV flux with quantum efficiency 3.8%.
We measure the quantum capacitance and probe thus directly the electronic density of states of the high mobility, Dirac type two-dimensional electron system, which forms on the surface of strained HgTe.

Here we show that observed magnetocapacitance oscillations probe---in contrast to magnetotransport---primarily the top surface.

Capacitance measurements constitute thus a powerful tool to probe only one topological surface and to reconstruct its Landau level spectrum for different positions of the Fermi energy.
This paper studies cobordism and concordance for virtual knots.

We define the affine index polynomial, prove that it is a concordance invariant for knots and links (explaining when it is defined for links), show that it is also invariant under certain forms of labeled cobordism and study a number of examples in relation to these phenomena.

Information on determinations of the four-ball genus of some virtual knots is obtained by via the affine index polynomial in conjunction with results on the genus of positive virtual knots using joint work with Dye and Kaestner.
The propagation of a detonation wave in a channel with linear expansion in a two-fractional suspension of aluminum particles in oxygen was investigated. Fractions of particles with diameters 3.5 µm and 1 µm were considered.

The verified semi-empirical detonation model was used taking into account transition from diffusion to kinetic regime of combustion of micro-sized aluminum particles.

The influence of the fractional composition of the mixture on propagation regimes and formation of transverse waves of cellular detonation is established.
We present experimental evidence for soliton bunching mediated by forward Brillouin scattering in the soliton rain regime of an ultralong fiber laser. Spatio-temporal dynamics show an initial acceleration followed by self-organization of the rain solitons.
Molecular salts and cocrystals of amino acids have potential applications as molecular materials with nonlinear optical, ferroelectric, piezoelectric, and other various target physical properties. The wide choice of amino acids and coformers makes it possible to design various crystal structures. The amino acid-maleic acid system provides a perfect example of a rich variety of crystal structures with different stoichiometries, symmetries and packing motifs built from the molecular building blocks, which are either exactly the same, or differ merely by protonation or as optical isomers. The present paper reports the crystal structures of two new salts of the DL-norvaline-maleic acid system with 1:1 and 2:1 stoichiometries, namely DL-norvalinium hydrogen maleate, C5H12NO2+·C4H3O4-, (I), and DL-norvalinium hydrogen maleate-DL-norvaline, C5H12NO2+·C4H3O4-·C5H11NO2, (II). These are the first examples of molecular salts of DL-norvaline with an organic anion. The crystal structure of (I) has the same C22(12) structure-forming motif which is common for hydrogen maleates of amino acids. The structure of (II) has dimeric cations. Of special interest is that the single crystals of (I) which are originally formed on crystallization from aqueous solution transform into single crystals of (II) if stored in the mother liquor for several hours.
This research extends existing experimental data for the brain blood vessels [1, 2] and presents the preliminary results of the numerical calculations. Experiments were performed to measure the blood flow in cerebral vessels and the obtained data was analyzed. To reconstruct the geometry of the Cerebral aneurysms (CA), DICOM images of real patients with aneurysms and ITK Snap [3] were used. In addition, the numerical calculations were performed in ANSYS (commercial software, License of Lavrentyev Institute of Hydrodynamics). The results of these numerical calculations show a high level of agreement with experimental data from the literature.
Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer genomics 1,2 . There are nine hot spots of DSBs located in human rDNA units 3–6 .

Here we describe that the profiles of these hot spots coincide with the profiles of γ-H2AX or H2AX, strongly suggesting a high level of in vivo breakage inside rDNA genes. The data were confirmed by microscopic observation of the largest γ-H2AX foci inside nucleoli in interphase chromosomes. In metaphase chromosomes, we observed that only some portion of rDNA clusters possess γ-H2AX foci and that all γ-H2AX foci co-localize with UBF-1 binding sites.

which strongly suggests that only active rDNA units possess the hot spots of DSBs. Both γ-H2AX and UBF-1 are epigenetically inherited and thus indicate the rDNA units that were active in the previous cell cycle. These results have implications for diverse fields, including epigenetics and cancer genomics.