Hengzongshu/ArticleAgent huggingface dataset:
We consider a one-dimensional layered structure that consists of an elastic material and a Maxwell fluid. It is assumed that the width of the layers is small compared with the size of the domain, where the problem is being solved. By employing the Nguetseng two-scale convergence technique, we have homogenized the equations that describe the mechanical system. For the homogenized equation, the limit cases of the Maxwell fluid with the small viscosity and with the small relaxation time are considered. The question of existence of the travelling wave solution for the homogenized equation is investigated.
An iron(II) clathrochelate having methylglyoxime rib fragment was treated with Fe(II)/t-BuOOH in 1,4-dioxane.The reaction resulted in substitution of the aldoxime hydrogen with 1,4-dioxanyl fragment by virtue of Minisci reaction mechanism.The resultant cage complex was identified with single crystal XRD, mass-spectrometry, 1 H, 13 C, 19 F, 11 B NMR spectroscopy, and examined with UV-Vis and IR spectroscopy.This reaction extends the range of synthetic approaches applicable for the functionalization of tris-dioximate cage complexes.
The paper deals with initial-boundary value problems for linear non-autonomous first order hyperbolic systems whose solutions stabilize to zero in a finite time.

To show this for $C^1$, we prove a general smoothing result implying that the solutions to the perturbed problems become eventually $C^1$-smooth for any $L^2$-initial data.

We prove that problems in this class remain exponentially stable in $L^2$ as well as in $C^1$ under small bounded perturbations.
Natural glucocorticoid hydrocortisone was suggested as a potent substitution for dexamethasone in the treatment of bronchopulmonary dysplasia in neonates.

The aim of this study was to investigate whether hydrocortisone is able to affect the expression of apoptotic genes and the intensity of naturally occurring cell death in the developing rat hippocampus. Hormone treatment decreased procaspase-3 and active caspase-3 levels as well as DNA fragmentation intensity in the hippocampal formation of one-week-old rats in 6 h after injection. These changes were accompanied by an upregulation of antiapoptotic protein Bcl-XL, while expression of proapoptotic protein Bax remained unchanged. The action of hydrocortisone was glucocorticoid receptor-independent, as the selective glucocorticoid receptor agonist dexamethasone did not affect either apoptotic protein levels or DNA fragmentation intensity in the hippocampal region.

The data are the first evidences for in vivo antiapoptotic effects of hydrocortisone in the developing hippocampus.
The scheme is based on the Langdon-Lasinski scheme, which is standard for numerical experiments in plasma physics.

We present a new scheme for the Maxwell's equations computations in three-dimensional domains, where size in one direction is much smaller than the other sizes. Our study is devoted to analysis of correct wave propagation due to the effects of using a finite-difference approximation. To show the main dependencies we present numerical results in one-dimensional case.

The results demonstrate, that the new scheme maintains the wave amplitude, the propagation speed and allows using of bigger time step in comparison with the Langdon-Lasinski scheme.
Most true lizards (Lacertidae) share a conservative karyotype, consisting of 18 pairs of macrochromosomes and one microchromosome pair. Homeologues of the microchromosome are present in other squamates and even in chickens. No structural autosomal microchromosome polymorphisms have been described previously in lizards.

We found homozygous and heterozygous carriers of a microchromosome variant in a Siberian population of the sand lizard, Lacerta agilis Linnaeus, 1758. The variant microchromosome was almost twice as long as the standard one. In heterozygotes at pachytene, the microchromosomes firstly pair in proximal regions and the central part of the longer axial element undergoes foldback synapsis, then its distal region pairs with the distal region of the standard partner. At metaphase-I, the heteromorphic microchromosome bivalents have a proximal chiasma. The content of the additional segment was Ag-NOR, C-like DAPI, CMA3 negative. FISH with telomere PNA probe did not detect interstitial (TTAGGG)n sequences in the heteromorphic and any other bivalents. Both homo- and heterozygous carriers were phenotypically normal. The presence of homozygotes shows that heterozygotes are fertile.

Reduction in the number of microchromosomes is a clear trend in squamate evolution, as a result of microchromosomes fusing together or with macrochromosomes. Our findings indicate that gaining additional DNA may lead to a transformation of microchromosomes into small macrochromosomes without fusion.
Long-range interactions between cold Rydberg atoms, which are used in many important applications, can be enhanced using F"orster resonances between collective many-body states controlled by an external electric field.

Here we report on the first experimental observation of highly resolved radio-frequency-assisted F"orster resonances in a few cold Rb Rydberg atoms. We also observed radio-frequency-induced F"orster resonances which cannot be tuned by a dc electric field.

They imply an efficient transition from van der Waals to resonant dipole-dipole interaction due to Floquet sidebands of Rydberg levels appearing in the rf field. This method can be applied to enhance the interactions of almost arbitrary Rydberg atoms with large principal quantum numbers.
The yeast Saccharomyces cerevisiae nucleoporin Nup116p serves as a docking site for both nuclear import and export factors. However, the mechanism for assembling Nup116p into the nuclear pore complex (NPC) has not been resolved. By conducting a two-hybrid screen with the carboxy (C)-terminal Nup116p region as bait, we identified Nup82p. The predicted coiled-coil region of Nup82p was not required for Nup116p interaction, making the binding requirements distinct from those for the Nsp1p-Nup82p-Nup159p subcomplex (N. Belgareh, C. Snay-Hodge, F. Pasteau, S. Dagher, C. N. Cole, and V. Doye, Mol. Biol. Cell 9:3475-3492, 1998). Immunoprecipitation experiments using yeast cell lysates resulted in the coisolation of a Nup116p-Nup82p subcomplex. Although the absence of Nup116p had no effect on the NPC localization of Nup82p, overexpression of C-terminal Nup116p in a nup116 null mutant resulted in Nup82p mislocalization. Moreover, NPC localization of Nup116p was specifically diminished in a nup82-Delta108 mutant after growth at 37 degrees C. Immunoelectron microscopy analysis showed Nup116p was localized on both the cytoplasmic and nuclear NPC faces. Its distribution was asymmetric with the majority at the cytoplasmic face. Taken together, these results suggest that Nup82p and Nup116p interact at the cytoplasmic NPC face, with nucleoplasmic Nup116p localization utilizing novel binding partners.
In this article, the results are shown of quantitative oil-and-gas potential assessment for the most promising Bathonian regional reservoir of the Jurassic sediments in the Yenisei-Khatanga territory and the adjacent territory of the Gydan petroleum province. The assessment is based on structural models and formation conditions reconstruction for the reservoir’s constituents, permeable complex and caprock. This method has been developed and published by the authors of the present article earlier. Tectonic and lithologic-and-facies criteria are considered. The methodology and results of the oil-and-gas potential assessment of the Bathonian reservoir are described.
The differential cross section of double bremsstrahlung (emission of two photons) from high-energy electron in the electric field of heavy atoms is derived.

The results are obtained with the exact account of the atomic field by means of the quasiclassical approximation to the wave functions and the Green's function in the external field.

It is shown that the Coulomb corrections to the differential cross section (the difference between the exact result and the result obtained in the leading Born approximation) correspond to small momentum transfers. The Coulomb corrections to the differential cross section of double bremsstrahlung are accumulated in the factor, which coincides with the corresponding factor in the differential cross section of single bremsstrahlung. At small momentum transfer, the Coulomb corrections to the differential cross section are very sensitive to the parameters of screening while the Coulomb corrections to the cross section integrated over the momentum transfer have the universal form.
7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate. Here we describe a study of 7-MG inhibition mechanism using molecular dynamics, fluorescence anisotropy and single-particle Förster resonance energy transfer (spFRET) microscopy approaches to elucidate intermolecular interactions between 7-MG, PARP-1 and nucleosomal DNA. It is shown that 7-MG competes with substrate NAD+ and its binding in the PARP-1 active site is mediated by hydrogen bonds and nonpolar interactions with the Gly863, Ala898, Ser904, and Tyr907 residues. 7-MG promotes formation of the PARP-1–nucleosome complexes and suppresses DNA-dependent PARP-1 automodification. This results in nonproductive trapping of PARP-1 on nucleosomes and likely prevents the removal of genotoxic DNA lesions.
As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real challenge. The HCV subgenomic replicon-containing cells are widely used for experimental studies of the HCV genome replication mechanisms, for drug testing in vitro and in studies of HCV drug resistance. The NS3/4A protease is essential for virus replication and, therefore, it is one of the most attractive targets for developing specific antiviral agents against HCV.

We have developed a stochastic model of subgenomic HCV replicon replication, in which the emergence and selection of drug resistant mutant viral RNAs in replicon cells is taken into account. Incorporation into the model of key NS3 protease mutations leading to resistance to BILN-2061 (A156T, D168V, R155Q), VX-950 (A156S, A156T, T54A) and SCH 503034 (A156T, A156S, T54A) inhibitors allows us to describe the long term dynamics of the viral RNA suppression for various inhibitor concentrations.

We theoretically showed that the observable difference between the viral RNA kinetics for different inhibitor concentrations can be explained by differences in the replication rate and inhibitor sensitivity of the mutant RNAs. The pre-existing mutants of the NS3 protease contribute more significantly to appearance of new resistant mutants during treatment with inhibitors than wild-type replicon. The model can be used to interpret the results of anti-HCV drug testing on replicon systems, as well as to estimate the efficacy of potential drugs and predict optimal schemes of their usage.
A method of imaging of ultra-fast processes, like explosion or fast combustion, at a synchrotron radiation beam is being developed at the Siberian Synchrotron and Teraherz Radiation Center (SSTRC). Two stations are operating at beam line 0 at the VEPP-3 storage ring and at beam line 8 at the VEPP-4M storage ring. Both stations are equipped with the detector for imaging of explosions DIMEX, based on high pressure ionization chamber, and allowing to record up to 100 one-dimensional images with the frame rate of 8 MHz. However, the maximum flux that DIMEX can detect is limited as well as spatial resolution and frame rate because of gas technology used. In view of significant increase of SR flux at the VEPP-4M beam line due to the new 9-pole 2 T wiggler, a new detector is being developed for this beam line, based on Si microstrip sensor. The first Si microstrip detector prototype has been mounted with new specially developed front-end ASIC that allows to record data with the rate of 50 MFrames/s. The first measurements with this prototype demonstrated significant improvement of all critical parameters of the detector compared to the gaseous version. The maximum detected photon rate before saturation is increased to ∼10000 photons/(chan x bunch) compared to ∼1000 photons/(chan x bunch) (Si detector has 50 µm channel pitch while gaseous detector has 100 µm channel pitch). Spatial resolution is improved from 250 µm to 72 µm and frame rate is increased by a factor more than 6.
Although antioxidants have been repeatedly tested in animal models and clinical studies, there is no evidence that antioxidants reduce already developed age-related decline. Recently we demonstrated that mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) delayed some manifestations of aging. Here we compared effects of SkQ1 and N-acetyl-L-cysteine (NAC) on age-dependent decline in blood levels of leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1), testosterone, dehydroepiandrosterone (DHEA) in Wistar and senescence-accelerated OXYS rats. When started late in life, supplementation with SkQ1 not only prevented age-related decline but also significantly reversed it. With NAC, all the observed effects were of the lower magnitude compared with SkQ1 (in spite of that dose of NAC was 16000 times higher). We suggest that supplementation with low doses of SkQ1 is a promising intervention to achieve a healthy ageing.
The proposed article considers the possibilities of various types of expert research on criminal cases of fraud in the field of automobile insurance (CTP, CASCO). On the example of illustrative cases from the published judicial practice in criminal cases, the features of the appointment of certain types of forensic examinations, their research potential are demonstrated. Clearly shows the wide the possibility of applying special knowledge to improve the effectiveness of detecting and investigating insurance fraud committed by staging and falsifying the circumstances of road accidents. The prospects for the use of atypical forensic examinations in criminal cases of relevant crimes are shown. The article is recommended not only to employees of investigative departments of law enforcement agencies, judges and experts, but also to a wide range of readers interested in countering fraud and other crimes committed in the insurance industry.
ОПЫТ СОЗДАНИЯ КНИГ ПАМЯТИ ДЕПОРТИРОВАННЫХ: ПРОБЛЕМЫ И РЕШЕНИЯИсследование выполнено при финансовой поддержке РФФИ (
The reproducibility of results obtained with rodent models depends on the genetic purity of the strain and the stability of the environment. However, another potential factor is changes in the gut microbiota due to the transmission of mother's bacteria during embryo transfer. In this study, we demonstrate the transmission of the microbiota and immune cell blood phenotype to the offspring of 2 strains, C57BL/6JNskrc and BALB/cJNskrc, from surrogate dams of different genotypes. Interstrain embryo transfer resulted in a change in the number of
The p53 protein is a key tumor suppressor in mammals. In response to various forms of genotoxic stress p53 stimulates expression of genes whose products induce cell cycle arrest and/or apoptosis. An E3-ubiquitin ligase, Mdm2 (mouse-double-minute 2) and its human ortholog Hdm2, physically interact with the amino-terminus of p53 to mediate its ubiquitin-mediated degradation via the proteasome. Thus, pharmacological inhibition of the p53-Mdm2 interaction leads to overall stabilization of p53 and stimulation of its anti-tumorigenic activity.

In this study we characterize the biological effects of a novel class of non-genotoxic isatin Schiff and Mannich base derivatives (ISMBDs) that stabilize p53 on the protein level. The likely mechanism behind their positive effect on p53 is mediated via the competitive interaction with Mdm2.

Importantly, unlike Nutlin, these compounds selectively promoted p53-mediated cell death. These novel pharmacological activators of p53 can serve as valuable molecular tools for probing p53-positive tumors and set up the stage for development of new anti-cancer drugs.
Raman lasers based on graded-index fiber (GIF) and other fibers

efficient conversion of highly-multimode pump beam from fiber-combined 938-nm laser diodes into a 976-nm Stokes beam; measured shapes of the output beams in GIF; analyzed in frames of a radially-dependent balance model with an account for the mode-selective feedback by FBG

record brightness enhancement (BE=73); high-quality Stokes beam generation and hole formation; hole width and BE values not consistent with experiment; possible reasons for the difference are discussed
The work is devoted to the study of the features and parameters of the momentum distributions of atoms laser cooled on weak optical transitions.

It was shown that atoms distributions are described by a bimodal momentum distribution whose characteristics depends on the parameters of the light field.

In a strong field a velocity selective coherent population trapping effect is observed.
Natural gas (methane, CH4) is widely considered as a promising energy carrier for mobile applications. Maximizing the storage capacity is the primary goal for the design of future storage media.

Here we report the CH4 storage properties in a family of isostructural (3,24)-connected porous materials, MFM-112a, MFM-115a, and MFM-132a, with different linker backbone functionalization. We also synthesized the partially deuterated versions of the above materials and applied solid-state 2H NMR spectroscopy to show that these three frameworks contain molecular rotors that exhibit motion in fast, medium, and slow regimes, respectively. In situ neutron powder diffraction studies on the binding sites for CD4 within MFM-132a and MFM-115a reveal that the primary binding site is located within the small pocket enclosed by the [(Cu2)3(isophthalate)3] window and three anthracene/phenyl panels.

Both MFM-112a and MFM-115a show excellent CH4 uptakes of 236 and 256 cm3 (STP) cm–3 (v/v) at 80 bar and room temperature, respectively. Significantly, MFM-115a displays an exceptionally high deliverable CH4 capacity of 208 v/v between 5 and 80 bar at room temperature, making it among the best performing metal–organic frameworks for CH4 storage. The open Cu(II) sites are the secondary/tertiary adsorption sites in these structures. Thus, we obtained direct experimental evidence showing that a tight cavity can generate a stronger binding affinity to gas molecules than open metal sites. Solid-state 2H NMR spectroscopy and neutron diffraction studies reveal that it is the combination of optimal molecular dynamics, pore geometry and size, and favorable binding sites that leads to the exceptional and different methane uptakes in these materials.
Journal Article Some substrate properties of analogues of oligothymidylates with p-s-C5′ bonds Get access V.N. Rybakov, V.N. Rybakov Institute of Cytology and Genetics, Siberian Division of the Academy of SciencesNovosibirsk 90, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar M.I. Rivkin, M.I. Rivkin Institute of Cytology and Genetics, Siberian Division of the Academy of SciencesNovosibirsk 90, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar V.P. Kumarev V.P. Kumarev Institute of Cytology and Genetics, Siberian Division of the Academy of SciencesNovosibirsk 90, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 9, Issue 1, 10 January 1981, Pages 189–201, https://doi.org/10.1093/nar/9.1.189 Published: 10 January 1981 Article history Received: 17 September 1980 Published: 10 January 1981
The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation.
Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors.
In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes.

Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes.

Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species. The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development.
This work describes a new method for in situ measuring the lithium layer thickness.

The method is based on the registration of the yield of 478 keV gamma-quanta of 7 Li(p,p'γ) 7 Li reaction. The results of measuring the radial distribution of the thickness of a lithium layer thermally deposited in vacuum on a cooled copper substrate are presented.

The possibility of using this method for certification of lithium targets used for boron neutron capture therapy is noted.
Samples of water-hydrate-paraffin sediments with the regions of different colored were obtained by passing the emulsion of CO2-saturated water into oil through a cooled tubular reactor Each of the regions was characterized by means of powder X-ray diffraction. It was shown that prevailing joint deposition of paraffins and hydrate occurs at some regions; complicated water-hydrate-paraffin agglomerates containing almost no admixture of the colored oil components. The possibility to form these agglomerates should be taken into account in the development of the methods preventing the deposition of hydrates and paraffins under real conditions.