Hengzongshu/ArticleAgent huggingface dataset:
Aim . To study the associations of electrophysiological signs of metabolic disorders with lipid and non-lipid risk factors in the urban 25–44-year-old population. Methods . A population survey (random sample) of Novosibirsk residents aged 25–44 years (656 men, 783 women) was conducted. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides were determined. Systolic / diastolic blood pressure, body mass index, presence of arterial hypertension, and smoking status were evaluated. The following electrocardiographic markers of metabolic disturbances were analyzed: baseline non-ischemic ST elevation depression >0.5 mm, baseline ST elevation >0.5 mm, and T-wave changes (flattening, amplitude reduction, inversion). Results . ST segment depression was detected in 4.2% of subjects (5.8% women, 2.4% men (p = 0.001)). ST segment elevation was detected in 28.5% of subjects (17.5% women, 41.6% men (p<0.001)). T-wave changes were detected in 18.9% of subjects (14.2% women, 24.5% men (p<0.001)). It was noted that men with elevated LDL-C levels and hypertension were more likely to have ST segment depression (1.4 and 1.9 times, respectively) than men without these abnormalities. In the general population, people with elevated LDL-C levels were 1.2 times more likely to have ST segment depression. Among men with ST segment elevation the concentration of LDL-C in the blood was 1.06 times higher than in men without ST segment elevation. People with a higher body mass index were 1.15 and 1.3 times more likely to have a T-wave change (in the general and female population, respectively). In the general population with T-wave changes, waist circumference and systolic blood pressure level were 1.02 and 1.02 times higher, respectively. Conclusion . ST segment elevation and depression, and T-wave changes are associated with lipid and non-lipid risk factors for ischemic heart disease. The data obtained indicate a potentiating effect of metabolic disorders in the body on the development of risk factors for ischemic heart disease and metabolic cardiomyopathy.
We report magnetotransport measurements in a HgTe quantum well with an inverted band structure, which is expected to be a two-dimensional (2D) topological insulator.

A small magnetic field perpendicular the 2D layer breaks the time-reversal symmetry and thereby suppresses the edge state transport. A linear magnetoresistance is observed in low magnetic fields when the chemical potential moves through the bulk gap. That magnetoresistance is well described by numerical calculations of the edge state magnetotransport in the presence of nonmagnetic disorder.

With the magnetic field increasing, both the local and nonlocal resistances first sharply decrease and then increase again in disagreement with the existing theories.
Endothelization of the luminal surface of vascular grafts is required for their long-term functioning.

Here, we have cultivated human endothelial cells (HUVEC) on different 3D matrices to assess cell proliferation, gene expression and select the best substrate for endothelization. 3D matrices were produced by electrospinning from solutions of poly(D,L-lactide-co-glycolide) (PLGA), polycaprolactone (PCL), and blends of PCL with gelatin (Gl) in hexafluoroisopropanol. Structure and surface properties of 3D matrices were characterized by SEM, AFM, and sessile drop analysis. Cell adhesion, viability, and proliferation were studied by SEM, Alamar Blue staining, and 5-ethynyl-2'-deoxyuridine (EdU) assay. Gene expression profiling was done on an Illumina HiSeq 2500 platform.

Obtained data indicated that 3D matrices produced from PCL with Gl and treated with glutaraldehyde provide the most suitable support for HUVEC adhesion and proliferation. Transcriptome sequencing has demonstrated a minimal difference of gene expression profile in HUVEC cultivated on the surface of these matrices as compared to tissue culture plastic, thus confirming these matrices as the best support for endothelization.
We present a comparative analysis of Raman scattering by acoustic and optical phonons in InAs/AlAs quantum dot superlattices grown on (001) and (311)B GaAs surfaces.

Doublets of folded longitudinal acoustic phonons up to the fifth order were observed in the Raman spectra of (001)- and (311)B-oriented quantum dot superlattices measured in polarized scattering geometries.

The energy positions of the folded acoustic phonons are well described by the elastic continuum model. Besides the acoustic phonons, the spectra display features related to confined transverse and longitudinal optical as well as interface phonons in quantum dots and spacer layers. Their frequency positions are discussed in terms of phonon confinement, elastic stress, and atomic intermixing.
Within the framework of stochastic reactive molecular dynamics simulations a statistical method for generating fluorinated graphene structures with desirable fluorine distribution is developed. Electronic transport properties of fluorinated graphene in a wide range of functionalization degrees and system ordering are investigated. A strong correlation between irregularities in fluorine distribution and electronic properties is found. In particular, proposed consideration allows for the reproduction of both the experimentally observed electron–hole asymmetry in transport properties of fluorinated graphene and a recently revealed conductivity peak at 10% fluoride content.
Elimaea fallax Bey-Bienko, Locusta migratoria Linnaeus and Trilophidia annulata (Thunberg) are recorded from Khabarovsky krai for the first time. The new data show that some species mainly associated with the subtropical and tropical regions of Asia expand their ranges northward and north-eastward. These shifts may be determined by both global warming and local transformations of habitats.
The charge deep-level transient spectroscopy (Q-DLTS) is applied to the study of the dislocation-rich Si layers grown on a surface composed of dense arrays of Ge islands prepared on the oxidized Si surface. This provides revealing three deep-level bands located at EV + 0.31 eV, EC – 0.35 eV and EC – 0.43 eV using the stripe-shaped p-i-n diodes fabricated on the basis of these layers. The most interesting observation is the local state recharging process which proceeds with low activation energy (∼50 meV) or without activation. The recharging may occur by carrier tunneling within deep-level bands owing to the high dislocation density ∼ 1011 - 1012 cm-2. This result is in favor of the suggestion on the presence of carrier transport between the deep states, which was previously derived from the excitation dependence of photoluminescence (PL) intensity. Electroluminescence (EL) spectra measured from the stripe edge of the same diodes contain two peaks centered near 1.32 and 1.55 μm. Comparison with PL spectra indicates that the EL peaks are generated from arsenic-contaminated and pure areas of the layers, respectively.
As a source of working gas, a discharge pre-chamber of an impulse wind tunnel was used.

The three-dimensional numerical simulation was performed using the software package ANSYS Fluent from the nozzle critical section to the combustor entrance with experimental initial data. The experiments were carried out with the following airflow parameters: M = 4, total pressure P0 = 5.7÷2.0 MPa and total temperature T0=1750÷1200 K.

Air flow characteristics and their distribution at the combustor entrance were obtained. It is established that the Mach number field non-uniformity in the flow core at the combustor entrance is 2.3% with a maximum thickness of the boundary layer of 10.7 mm. A good agreement between the calculated and experimental data was obtained.
The work deals with an iteration method for numerical solving the equilibrium problem of two-dimensional elastic body with a crack under the nonpenetration condition. The method is based on the domain decomposition and Uzawa's algorithm. To construct an algorithm, the domain is partitioned into two subdomains whose common boundary contains the crack. In each subdomain the linear problems are solved. We use Lagrangian multipliers to couple the solutions and provide the nonpenetration condition on the crack.
В работе изучаются динамика и факторы пространственной концентрации экономической активности в России, эмпирическими методами тестируются гипотезы агломерационной экономики.Анализ показал, что в России идет рост неравномерности распределения ресурсов и результатов производства, причем скорость этого процесса достаточно высока.Факторами, определяющими межрегиональную дивергенцию в России, являются плотность населения, размер и доступность рынков, а также структура экономики, т. е. те детерминанты, которые имеют рыночную основу и которые выдвигает в качестве ключевых агломерационная экономика.Результаты анализа не подтвердили эффективность межрегиональных трансфертов и государственных инвестиций для снижения различий между
Autophagy is a degradative process in which cellular organelles and proteins are recycled to restore homeostasis and cellular metabolism. Autophagy can be either a prosurvival or a prodeath process and remains one of the most fundamental processes for cell vitality. Thus autophagy modulation is an important approach for reinforcement anticancer therapeutics. Earlier we have demonstrated that recombinant analog of human milk protein lactaptin (RL2) induced apoptosis of various cultured cancer cells and activated lipidation of microtubule-associated protein 1 light chain 3 (LC3). In this study we investigated whether autophagy inhibitors—chloroquine (CQ), Ku55933 (Ku), and 3-methyladenine (3MA)—or inducer—rapamycin (Rap)—can enhance cytotoxic activity of lactaptin analog in cancer cells and its anticancer activity in the mice model. Western Blot analysis revealed that RL2 induced short-term autophagy in MDA-MB-231 and MCF-7 cells at early stages of incubation and that these data were confirmed by the transmission electron microscopy of autophagosome/autophagolysosome formation. RL2 stimulates reactive oxygen species (ROS) production, autophagosomes accumulation, upregulation of ATG5 with processing of LC3I to LC3II, and downregulation of p62/sequestosome 1 (p62). We have shown that autophagy modulators, CQ, Ku, and Rap, synergistically increased cytotoxicity of RL2, and RL2 with CQ induced autophagic cell death. In addition, CQ, Ku, and Rap in combination with RL2 decreased activity of lysosomal protease Cathepsin D. More importantly, combining RL2 with CQ, we improved antitumor effect in mice. Detected synergistic cytotoxic effects of both types of autophagy regulators, inhibitors, and inducers with RL2 against cancer cells allow us to believe that these combinations can be a basis for the new anticancer approach. Finally, we suppose that CQ and Rap promoting of short-term RL2-induced autophagy interlinks with final autophagic cell death.
The kernel machine-based regression is an efficient approach to region-based association analysis aimed at identification of rare genetic variants. However, this method is computationally complex. The running time of kernel-based association analysis becomes especially long for samples with genetic (sub) structures, thus increasing the need to develop new and effective methods, algorithms, and software packages.

We have developed a new R-package called fast family-based sequence kernel association test (FFBSKAT) for analysis of quantitative traits in samples of related individuals. This software implements a score-based variance component test to assess the association of a given set of single nucleotide polymorphisms with a continuous phenotype. We compared the performance of our software with that of two existing software for family-based sequence kernel association testing, namely, ASKAT and famSKAT, using the Genetic Analysis Workshop 17 family sample.

Results demonstrate that FFBSKAT is several times faster than other available programs. In addition, the calculations of the three-compared software were similarly accurate. With respect to the available analysis modes, we combined the advantages of both ASKAT and famSKAT and added new options to empower FFBSKAT users. The FFBSKAT package is fast, user-friendly, and provides an easy-to-use method to perform whole-exome kernel machine-based regression association analysis of quantitative traits in samples of related individuals.
Based on the results of the study of materials of the Tartas-1 and Ust-Tartas-1 sites and radiocarbon dating, the article explores the Baraba culture of the early Neolithic era (VII thousand BC, entering the VIII and VI thousand BC).

The Neolithic parking lot, studied at Tartas-1, is represented by two structures, a smokehouse and a series of pits for storing fish. A significant number of finds from bone and stone have been found. The ceramic complex is of particular importance. These are flat-bottomed containers, made in the technique of orderly patchwork, using a molding cord on the top of the vessel, and roller-flow around the perimeter of the bottom. The ornament is represented by a complex plot of an asymmetrical composition. The stone industry is characterized as plate-like with a high value of linear technology. The absence of stone arrowheads is characteristic of this. Fish was harvested in pits. At different stages of operation, corpses of different animals were placed inside. The bones of Late Pleistocene fauna have been revealed. The original ritual complex was discovered on the monument of Ust-Tartas-1.

In Baraba, the ceramics of Tartas-1 and Ust-Tartas-1 are similar to the ceramics of Autodrome-2/2, which is related to Boborykinskaya culture, direct dating of ceramics attributed to the last quarter 6th – mid 5th thousand BC. The early Neolithic sites of the North with complexes with flat-bottomed utensils date from the end of the 7th – first half of 6th thousand BC. Neolithic flat-bottomed utensils of Western Siberia should be assessed as a phenomenon of general historical and stage nature. The classification of Tartas complexes with flat-bottomed utensils to Boborykinskaya culture is inaccurate and incorrect. The latter appears to be much younger in time. The discoveries of sites with flat-bottomed ceramics allow a completely new idea of the dynamics of historical and cultural processes in the forest and steppe of the Irtysh area.
Polynuclear bismuth(III) iodide complexes with 1-ethyl-4-dimethylaminopyridinium (1-EtDMAP) 4 [Bi 8 I 28 ] ( 1 ) and (1-EtDMAP)BiI 4 ( 2 ) have been obtained by the reactions of bismuth(III) iodide with an organic iodide salt cations in organic solvents and characterized by X-ray diffraction. The optical properties and thermal stability of the obtained compounds have been studied.
We consider magnetic Tonelli Hamiltonian systems on the cotangent bundle of the 2-sphere, where the magnetic form is not necessarily exact. It is known that, on very low and on high energy levels, these systems may have only finitely many periodic orbits.

Our main result asserts that almost all energy levels in a precisely characterized intermediate range $(e_0,e_1)$ possess infinitely many periodic orbits.

Such a range of energies is non-empty, for instance, in the physically relevant case where the Tonelli Lagrangian is a kinetic energy and the magnetic form is oscillating (in which case, $e_0=0$ is the minimal energy of the system).
Initially, the Armoury experts identified the helmet as a 'Manchu hat'.

The technological analysis suggests that letters on the band were gilt, and those on the visor, silvered. The typological analysis suggests that the headgear was made by Central Asian (Mongolian or Oirat) artisans in the late 16th or early 17th century.

The specimen may be used as a standard for dating and attributing randomly found and unattributed battle and ceremonial headgears worn by late medieval and early modern Central Asian nomads.
The regularities of phase formation and thermal stability in Fe3Si(111)/Si(111) structure at stepped vacuum annealing (350, 450 and 550 °C) were investigated. The layer of 32 nm Fe3Si was deposited onto Si(111) substrate by molecular beam epitaxy at 260 °C. Transmission electron microscopy (TEM) measurements demonstrated that the film thickness increases by ∼19 % at 350 °C annealing without changing the phase composition. The polycrystalline -FeSi sublayer was formed on the interface at 450 °C annealing. Further annealing at 550 °C led to the ∼ 80 nm polycrystalline film formation containing the crystallites of -FeSi, Fe5Si3, and β-FeSi2 phases.
Siberia is one of the coldest environments on Earth and has great seasonal temperature variation. Long-term settlement in northern Siberia undoubtedly required biological adaptation to severe cold stress, dramatic variation in photoperiod, and limited food resources. In addition, recent archeological studies show that humans first occupied Siberia at least 45,000 years ago; yet our understanding of the demographic history of modern indigenous Siberians remains incomplete. In this study, we use whole-exome sequencing data from the Nganasans and Yakuts to infer the evolutionary history of these two indigenous Siberian populations. Recognizing the complexity of the adaptive process, we designed a model-based test to systematically search for signatures of polygenic selection. Our approach accounts for stochasticity in the demographic process and the hitchhiking effect of classic selective sweeps, as well as potential biases resulting from recombination rate and mutation rate heterogeneity. Our demographic inference shows that the Nganasans and Yakuts diverged ∼12,000-13,000 years ago from East-Asian ancestors in a process involving continuous gene flow. Our polygenic selection scan identifies seven candidate gene sets with Siberian-specific signals. Three of these gene sets are related to diet, especially to fat metabolism, consistent with the hypothesis of adaptation to a fat-rich animal diet. Additional testing rejects the effect of hitchhiking and favors a model in which selection yields small allele frequency changes at multiple unlinked genes.
Three-dimensional computer simulations of the dynamics of sessile droplets in an electric field and without it are carried out on the basis of the lattice Boltzmann method (LBM). The dielectric droplets are placed on the surface of the lower electrode. The electrical and hydrodynamic parts of the problem are solved simultaneously. After application of an electric field, the droplets begin to lengthen in the field direction. The contact angle is measured after the droplet acquires its equilibrium shape. It is shown that the contact angle slightly increases with increasing the electric field due to electrostatic forces. Above a certain critical value of the electrical Bond number, the droplets cannot acquire a stable form, the elongation becomes unlimited, and the droplets are destroyed.
Д. Г. Симонов  Военный министр Российского правительства генерал-лейтенант Н. А. Степанов В статье рассматривается биография генерала Николая Александровича Степанова применительно к его службе в старой Русской армии и в рядах антибольшевистских вооруженных формирований в период гражданской войны.Проанализирована его деятельность на посту военного министра Российского правительства адмирала А. В. Колчака.Выявлены объективные и субъективные факторы, обусловившие провал деятельности генерала Степанова по подготовке в тылу пополнений для действовавшей на фронте армии.Ключевые слова: генерал Николай Александрович Степанов, армия, Сибирь, военное министерство Период гражданской войны является уникальным в истории Сибири.Общественнополитические процессы, протекавшие здесь в эти годы, имели общероссийское значение.В Сибири было организовано Российское правительство и под его эгидой создана самая крупная в России группировка антибольшевистских вооруженных сил.Организация борьбы с советской властью являлась главной задачей Российского правительства, в силу чего деятельность военного министерства, входившего в его состав, приобретала особо важное значение.Многое зависело и от фигуры военного министра.За год существования правительства этот пост занимали последовательно семь человек: вице-адмирал А. В. Колчак (ноябрь 1918 г.), генерал-майор В. И. Сурин (временно исправлял должность в ноябре-декабре 1918 г.), генерал-майор Н
The paper presents the results of numerical studies of self-ignition and supersonic combustion of cold hydrogen jet supplied to the M=2 vitiated air flow. The calculations are carried out using the ANSYS Fluent on the basis of the full Favre-averaged Navier-Stokes equations supplemented by the κ–ω SST turbulence model and several kinetic mechanisms including 1, 16 and 38 reactions. The results of calculations of mixing of a cold hydrogen jet and a hot inert mixture are in good qualitative and quantitative agreement with experimental data. The results obtained for the reactive flow show that in the calculation the combustion layer is closer to the channel bottom wall than in the experiment, and the temperature of the reaction product is by 10 % lower.
We report results from a search for the decay ${B}_{s}^{0}\ensuremath{\rightarrow}\ensuremath{\eta}\ensuremath{\eta}$ using $121.4\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of data collected at the $\mathrm{\ensuremath{\Upsilon}}(5S)$ resonance with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider. We do not observe any signal and set an upper limit on the branching fraction of $14.3\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ at 90% confidence level. This result represents a significant improvement over the previous most stringent limit.
The phytohormone auxin regulates virtually every developmental process in land plants. This regulation is mediated via de-repression of DNA-binding auxin response factors (ARFs). ARFs bind TGTC-containing auxin response cis-elements (AuxREs), but there is growing evidence that additional cis-elements occur in auxin-responsive regulatory regions. The repertoire of auxin-related cis-elements and their involvement in different modes of auxin response are not yet known.

Here we analyze the enrichment of nucleotide hexamers in upstream regions of auxin-responsive genes associated with auxin up- or down-regulation, with early or late response, ARF-binding domains, and with different chromatin states.

Intriguingly, hexamers potentially bound by basic helix-loop-helix (bHLH) and basic leucine zipper (bZIP) factors as well as a family of A/T-rich hexamers are more highly enriched in auxin-responsive regions than canonical TGTC-containing AuxREs. We classify and annotate the whole spectrum of enriched hexamers and discuss their patterns of enrichment related to different modes of auxin response.
Аннотация.Для QTL на пшеничной хромосоме 2A, ассоциированного с активностью липоксигеназы в условиях засухи

было выявлено 19 кандидатных генов с взаимосвязанными функциями

Среди них гены метаболических путей полифосфатов инозита, альдо
An application of sensitivity operator-based algorithms to an inverse modeling scenario of urban air quality is presented.

A source identification problem and a concentration field continuation problem are solved and analyzed.

The analysis of the sensitivity operator allows one to obtain a preliminary estimate of the source identification problem solution.
In the framework of the lattice dynamics method, the densities of the phonon states of tetrabutylammonium bromide ionic clathrate hydrate have been found. The dynamic stability of the hydrate is shown for a number of temperatures. Using the developed statistical-thermodynamic theory, the free energy curves have been constructed for a wide range of temperatures at different unit cell volumes and, based on the calculated data, the lines of thermal expansion of the hydrate have been constructed.