Hengzongshu/ArticleAgent huggingface dataset:
Purpose of the study. To study the results of prepectoral reconstruction of the mammary gland after subcutaneous mastectomy for cancer with additional covering of the implant with a polypropylene mesh implant. (IPPBR)

Materials and methods. Case-series of 6 patients with luminal breast cancer T1–2N0M0 aged from 34 to 47 years. IPPBR was performed after subcutaneous mastectomy (nipple sparing in 2 cases). The anterior surface of implants (Polytech, Germany) was covered with Ethicon/Johnson& Johnson (USA) simple polypropylene mesh. The mesh was fixed with interrupted absorbable sutures to the big pectoral muscle.

Results. There was one successfully treated minor complication: limited skin incision necrosis. No other complications or tumor recurrences were registrated during observation period. The aesthetic results (mainly shape and volume breasts symmetry, nipples symmetry after nipple- sparing operation) were estimated as good both by surgeon and all patients. Periprosthetic connective tissue growth was minimal (grade I due to Baker’s scale) in all cases. Conclusion. The first results of the use of a simple mesh polypropylene implant in cases of breast cancer after subcutaneous mastectomy for cancer for the prevention of implant migration are encouraging. The degree of development of periprosthetic scar contracture is minimal.
X chromosome inactivation is a complex process that occurs in marsupial and eutherian mammals. The process is thought to have arisen during the differentiation of mammalian sex chromosomes to achieve an equal dosage of X chromosome genes in males and females.

The differences in the X chromosome inactivation processes in marsupial and eutherian mammals are considered

and the hypotheses on its origin and evolution are discussed in this review.
This comparison is sensitive to the effect of two-photon exchange contributions which may be the cause for inconsistent extractions of the proton form factors obtained using different methods.

The experiment was performed at storage ring VEPP–3, Novosibirsk at energies of positron/electron beams of 1.0 and 1.6 GeV with electron/positron scattering angles θ = 65÷105° for the first case and 15÷25° and 55÷75° for the second case. Details of the experiment and the preliminary results are presented.

We describe a precise measurement of the ratio of the (e+ p) to (e− p) elastic scattering cross sections.
Synaptonemal complex analysis were carried out by electron microscopy of surface spread spermatocytes of the domestic goat.

Pairing patterns of the sex chromosomes and autosomes were described.
Developing A.D. Aleksandrov's ideas, the first author proposed the following approach to study of rigidity problems for the boundary of a C 0 -submanifold in a smooth Riemannian manifold.

Let Y1 be a two-dimensional compact connected C 0 -submanifold with non-empty boundary in some smooth two-dimensional Riemannian manifold (X, g) without boundary. Let us consider the intrinsic metric (the infimum of the lengths of paths, connecting a pair of points.) of the interior Int Y1 of Y1, and extend it by continuity (operation lim) to the boundary points of ∂Y1.

In this paper the rigidity conditions are studied, i.e., when the constructed limiting metric defines ∂Y1 up to isometry of ambient space (X, g). We also consider the case dim Yj = dim X = n, n > 2.
Justification Given the large number of reports on the peculiarities of liver lesions during the Sars-Cov-2 infection [1], a team of experts who participated in the 23rd Congress of the Scientific Society of Gastroenterologists of Russia and 15 National Congress of Therapists of November 19, 2020 decided to make additions to the Russian Consensus of “Hyperammonemia in Adults” published early 2020 [2, 3].
Kidney collecting duct principal cells play a key role in regulated tubular reabsorption of water and sodium and secretion of potassium. The importance of this function for the maintenance of the osmotic homeostasis of the whole organism motivates extensive study of the ion transport properties of collecting duct principal cells. We performed experimental measurements of cell volume and intracellular sodium concentration in rat renal collecting duct principal cells from the outer medulla (OMCD) and used a mathematical model describing transmembrane ion fluxes to analyze the experimental data. The sodium and chloride concentrations ([Na+]in = 37.3 ± 3.3 mM, [Cl-]in = 32.2 ± 4.0 mM) in OMCD cells were quantitatively estimated. Correspondence between the experimentally measured cell physiological characteristics and the values of model permeability parameters was established. Plasma membrane permeabilities and the rates of transmembrane fluxes for sodium, potassium and chloride ions were estimated on the basis of ion substitution experiments and model predictions. In particular, calculated sodium (PNa), potassium (PK) and chloride (PCl) permeabilities were equal to 3.2 × 10-6 cm/s, 1.0 × 10-5 cm/s and 3.0 × 10-6 cm/s, respectively. This approach sets grounds for utilization of experimental measurements of intracellular sodium concentration and cell volume to quantify the ion permeabilities of OMCD principal cells and aids us in understanding the physiology of the adjustment of renal sodium and potassium excretion.
Aims. To estimate the prevalence of type 2 diabetes mellitus (T2DM) in different age groups of the adult population of Novosibirsk, according to epidemiological studies in 20032005 and 20132016. Methods. We examined a representative population sample (assessed in 20032005) of men and women aged 4569 years in two administrative districts of Novosibirsk, as a part of the international HAPIEE project. According to the tables of random numbers, representative samples of men and women aged 4569 years were formed, to which letters were sent, inviting them to pass for examination. During 20132016, a second population survey was conducted on a random representative sample of a population of 2544-year-olds of both sexes. Participants were residents of one of the districts of Novosibirsk. T2DM and impaired fasting glucose (IFG) were diagnosed using fasting plasma glucose (FPG) levels (diabetes: FPG 7.0 mmol/l; IFG: FPG 6.16.9 mmol/l). Results. The prevalence of T2DM among residents aged 4569 years was 11.3%, and overall, no significant difference in prevalence was found between females and males (11.3% vs. 11.0%). However, the overall prevalence of T2DM among residents aged 2544 years was 2.2%, and prevalence was higher in men (3.5%) than in women (1.1%), p 0.05. High prevalence of IFG was found in the 4569 age group (18.2%, in 20032005), and in the younger age group of 2544 years (21.6%, in 20132016). The high rate among young individuals is particularly alarming. Less than one half (4.8 out of 11.3%) of participants aged 4569 tested positive for T2DM, and only one in the age group 2544 years knew he/she had diabetes. This indicates a lack of knowledge among Siberians about their problem with diabetes. Conclusion. Approximately one in five adults had IFG. Among the adult population aged 4569 (in 20032005), 18.2% had IFG and 11.3% had T2DM. In individuals aged 2544 years in 20132016, IFG was observed in 21.6%, and 2.2% had T2DM (p0.05).
In 2017, AWAKE demonstrated the seeded self-modulation (SSM) of a 400 GeV proton beam from the Super Proton Synchrotron at CERN. The angular distribution of the protons deflected due to SSM is a quantitative measure of the process, which agrees with simulations by the two-dimensional (axisymmetric) particle-in-cell code LCODE to about 5%. The agreement is achieved in beam population scans at two selected plasma densities and in the scan of longitudinal plasma density gradient. The agreement is reached only in the case of a wide enough simulation box (several plasma wavelengths) that is closer to experimental conditions, but requires more computational power. Therefore, particle-in-cell codes can be used to interpret the SSM physics underlying the experimental data.
High-resolution chromosome analysis of eight Palaearctic and Oriental species of white-toothed shrews reveals almost complete chromosomal homology between the karyotypes studied, and extensive G-band homology is demonstrated even between species of the genera Crocidura and Suncus.

Robertsonian translocations, tandem fusions, fissions, whole-arm reciprocal translocations, centromeric shifts, heterochromatin additions, and inversions are identified as the main mechanisms of chromosomal evolution.

The evolutionary relationships of the Eurasian crocidurines under study are reconstructed and a hypothetical ancestral karyotype with 44 chromosomes is proposed.
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. People infected with HIV-1 are a particularly vulnerable group, as they may be at a higher risk than the general population of contracting COVID-19 with clinical complications. For such patients, drugs with a broad spectrum of antiviral activity are of paramount importance. Glycyrrhizinic acid (Glyc) and its derivatives are promising biologically active compounds for the development of such broad-spectrum antiviral agents. In this work, derivatives of Glyc obtained by acylation with nicotinic acid were investigated. The resulting preparation, Glycyvir, is a multi-component mixture containing mainly mono-, di-, tri- and tetranicotinates. The composition of Glycyvir was characterized by HPLC-MS/MS and its toxicity assessed in cell culture. Antiviral activity against three strains of SARS-CoV-2 was tested in vitro on Vero E6 cells by MTT assay. Glycyvir was shown to inhibit SARS-CoV-2 replication in vitro (IC
A model of a liquid bridge that appears in a gap between two cylinders, inclined to the horizon, is developed.

The shapes of the free surface of the bridges are calculated by the hydrostatic equations. The velocity field in the current bridge flow is calculated by the method of boundary elements from the Navier–Stokes equation reduced to the Laplace equation. For liquid flows in narrow gaps, an approximate model is constructed.

The forces acting on the cylinders are determined. The volumetric flow rates of the liquid in the inclined bridge are calculated. The results are compared with the calculations obtained by the boundary element method.
This paper addresses the analysis of the applicability of water as a working fluid for the new adsorptive heat transformation (AHT) cycle "Heat from Cold" (HeCol). The cycle proposed for cold countries operates at the ambient temperature below 0 °C. In this work, an aqueous solution of calcium chloride is proposed instead of liquid water to prevent the ice formation in the evaporator and condenser. The proposed water-based cycle is compared with the common methanol-based HeCol one in terms of the specific useful heat generated per cycle. The effect of the CaCl2 solution on the cycle boundary pressures and its useful heat is studied both theoretically and experimentally. This approach can be extended to other adsorptive heat transformation cycles working at an evaporator or condenser temperature below 0 °C.
Carbon nanotubes (CNTs) possess both remarkable optical properties and high potential for integration in various photonic devices. We overview, here, recent progress in CNT applications in fibre optics putting particular emphasis on fibre lasers. We discuss fabrication and characterisation of different CNTs, development of CNT-based saturable absorbers (CNT-SA), their integration and operation in fibre laser cavities putting emphasis on state-of-the-art fibre lasers, mode locked using CNT-SA. We discuss new design concepts of high-performance ultrafast operation fibre lasers covering ytterbium (Yb), bismuth (Bi), erbium (Er), thulium (Tm) and holmium (Ho)-doped fibre lasers.
The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods which consider variant association with multiple traits jointly have been developed. However, most effort has been put on improving discovery power: how to replicate and interpret these discovered pleiotropic loci using multivariate methods has yet to be discussed fully.

Using only multiple publicly available single-trait GWAS summary statistics, we develop a fast and flexible multi-trait framework that contains modules for (i) multi-trait genetic discovery, (ii) replication of locus pleiotropic profile, and (iii) multi-trait conditional analysis. The procedure is able to handle any level of sample overlap.

As an empirical example, we discovered and replicated 23 novel pleiotropic loci for human anthropometry and evaluated their pleiotropic effects on other traits. By applying conditional multivariate analysis on the 23 loci, we discovered and replicated two additional multi-trait associated SNPs. Our results provide empirical evidence that multi-trait analysis allows detection of additional, replicable, highly pleiotropic genetic associations without genotyping additional individuals.
Recently, much attention has been paid to reducing environmental damage to the environment throughout the country. Over the past twenty years, Public Joint-Stock Company "Gazprom" has been working on the implementation of environmental projects for the transfer of motor vehicles to alternative motor fuels.

The report suggests a toolkit for assessing the impact of energy saving projects on the environment, based on the adaptation of the input-output model for the fuel and energy complex. The model is based on the assumption that the main amount of greenhouse gas emissions is produced by burning fossil fuels. As an indicator for estimation of environmental efficiency of the projects has proposed the coefficient of carbon intensity - the amount of carbon dioxide released per unit of the final product of the industry.

This ratio reflects the impact of industries on the environment. The advantage of the input-output model is the opportunity to conduct a comparative analysis of the environmental load of industries on the environment and to determine the multiplicative effect of implementing energy-saving projects.
Recent progress in the design, synthesis and characterization of chalcogen-nitrogen π-heterocycles, mostly 1,2,5-chalcogenadiazoles (chalcogen: S, Se and Te) and their fused derivatives, possessing positive electron affinity

their use in preparation of charge-transfer complexes and radical-anion salts

candidate building blocks of molecule-based electrical and magnetic functional materials
Downstream development of disturbance waves properties in annular regime of gas - liquid flow was conducted in adiabatic air-water downwards flow in a vertical pipe with inner diameter of 11.7 mm. The measurements were conducted using brightness-based laser-induced fluorescence technique. Instantaneous distributions of local thickness of liquid film along one longitudinal section of the duct over the first 45 cm from the inlet were obtained with sampling frequency of 10 kHz. Based on these spatiotemporal plots, dependence of local average velocity of disturbance waves on downstream distance was obtained for a wide range of gas and liquid flow rates. Three main stages of flow development were identified: a stage prior to formation of disturbance waves, a stage of constant acceleration of disturbance waves and a stage of deceleration nearly compensating the initial acceleration. Transitions to both second and third stages occur closer to the inlet at higher gas velocities and lower liquid flow rates. The initial acceleration is defined by the effect of the gas shear; it grows in parabolic manner with superficial gas velocity and shows weak dependence on liquid flow rate. The deceleration is supposed to occur due to entrainment of liquid from disturbance waves.
This work is devoted to experimental studies of the effect of synthesis conditions on formation of single-layer graphene on the copper surface.

Under the conditions of formation and growth of single-layer graphene, it is shown that characteristic times of graphite nuclei formation are about 1 min and times of primary layer growth are about 0.5 min. The subsequent layers form in 10 min.

It is shown that hydrogen concentration at the initial stage of synthesis affects the growth rate of the second layer significantly.
A mathematical model of nonlinear deformation of ice samples from distilled water is implemented. An algorithm for numerical solution of corresponding boundary-value problem is proposed and realized. Results of the numerical modeling have been compared to experimental data on the three-point bending of ice beams.
Over the decades, the application of mechanical force to influence chemical reactions has been called by various names: mechanochemistry, tribochemistry, mechanical alloying, to name but a few. The evolution of these terms has largely mirrored the understanding of the field. But what is meant by these terms, why have they evolved, and does it really matter how a process is called? Which parameters should be defined to describe unambiguously the experimental conditions such that others can reproduce the results, or to allow a meaningful comparison between processes explored under different conditions? Can the information on the process be encoded in a clear, concise, and self-explanatory way? We address these questions in this Opinion contribution, which we hope will spark timely and constructive discussion across the international mechanochemical community.
We investigate a single-particle density of states (DOS) in strongly disordered two-dimensional high dielectric permittivity systems with logarithmic Coulomb interaction between particles.

We derive self-consistent DOS at zero temperature. We carry out zero- and finite-temperature Monte Carlo numerical studies of the DOS.

We show that it is appreciably suppressed as compared to the DOS expected from the Efros-Shklovskii approach. We find the perfect agreement between the numerical and analytical results at zero temperature, observing a hardening of the Coulomb gap with the increasing electrostatic screening length. At finite temperatures, we reveal a striking scaling of the DOS as a function of energy normalized to the temperature of the system.
Continuously pumped passive nonlinear cavities can be harnessed for the creation of novel optical frequency combs. While most research has focused on third-order "Kerr" nonlinear interactions, recent studies have shown that frequency comb formation can also occur via second-order nonlinear effects. Here, we report on the formation of quadratic combs in optical parametric oscillator (OPO) configurations. Specifically, we demonstrate that optical frequency combs can be generated in the parametric region around half of the pump frequency in a continuously driven OPO. We also model the OPO dynamics through a single time-domain mean-field equation, identifying previously unknown dynamical regimes, induced by modulation instabilities, which lead to comb formation. Numerical simulation results are in good agreement with experimentally observed spectra. Moreover, the analysis of the coherence properties of the simulated spectra shows the existence of correlated and phase-locked combs. Our results reveal previously unnoticed dynamics of an apparently well assessed optical system, and can lead to a new class of frequency comb sources that may stimulate novel applications by enabling straightforward access to elusive spectral regions, such as the midinfrared.
The influence of the surface modification of multi-walled carbon nanotubes (MWCNT) with nitrogen-containing compounds on the performance of 40 wt% Pt/MWCNT catalysts in the oxygen electroreduction reaction (ORR) was investigated using a rotating disk electrode (RDE) at 10–35 °C in 0.1 M HClO4 as electrolyte in electrochemical cell, and in a hydrogen–oxygen polymer electrolyte membrane fuel cell (PEMFC) at 82 °C. The catalysts were characterized by low-temperature nitrogen adsorption, XPS, TEM, gas-phase CO titration, electrooxidation of the adsorbed CO monolayer, and cyclic voltammetry. It was shown that the modification of MWCNT with melamine–formaldehyde resin leads to the surface nitrogen concentration up to 8.3 at.% (CNT-MF sample). The 40 wt% Pt/CNT-MF catalyst with 0.1 mg cm−2 Pt loading on the cathode showed a good performance in PEMFC (~ 0.61 W cm−2) and a high utilization ratio (0.84) of Pt in membrane electrode assembly as compared to Pt/CNT catalyst (~ 0.37 W cm−2 and utilization of 0.29). The higher power density of nitrogen-modified catalysts was ascribed to a higher utilization of Pt in the electrode layer.
We introduce the notion of a (virtual) multi-switch which generalizes the notion of a (virtual) switch. Using (virtual) multi-switches we introduce a general approach of how to construct representations of (virtual) braid groups by automorphisms of algebraic systems. As a corollary we introduce new representations of virtual braid groups which generalize several previously known representations.
Aim. The aim of this work is to summarize the available data on zoogeographic analysis and fauna of the bats of the Altai-Sayan region. Discussion. The chiropterofauna of the AltaiSayan highlands includes the representatives of 13 species. The obtained data on the distribution of bats in the region made it possible for the first time to carry out a zoogeographic analysis of the chiropterofauna of the Altai-Sayan highland. The faunal complex of bats in the study area and adjacent territories is represented by boreal, European and Central Asian species. The cluster analysis by Jaccard coefficient allowed us to distinguish two main chiropterological complexes: Altai-Sayan and Ubsunur. Our boundary between these complexes coincides or is close to the biogeographic boundaries drawn for various groups of vertebrates and invertebrates, as well as plants. Conclusion. Altai-Sayan territory is inhabited by 13 bat species of six genera belonging to Vespertilionidae family. The most common species are the following: eastern water bat – Myotis petax Hollister, 1912; Siberian bat – Myotis sibiricus Kastschenko, 1905; Ikonnikov's bat – Myotis ikonnikov Ognev, 1912; Northern bat – Eptesicus nilssonii Keyserling, Blasius, 1839; Parti-coloured bat – Vespertilio murinus Linnaeus, 1758; Ognev's long-eared bat – Plecotus ognevi Kishida, 1927. In the fauna of the region, the boundary between two chiropterological complexes (Altai-Sayan and Ubsunur) runs through Kurtushibinsk-Usinsk province.
The biological and clinical relevance of glycosylation is becoming increasingly recognized, leading to a growing interest in large-scale clinical and population-based studies. In the past few years, several methods for high-throughput analysis of glycans have been developed, but thorough validation and standardization of these methods is required before significant resources are invested in large-scale studies.

In this study, we compared liquid chromatography, capillary gel electrophoresis, and two MS methods for quantitative profiling of N-glycosylation of IgG in the same data set of 1201 individuals. To evaluate the accuracy of the four methods we then performed analysis of association with genetic polymorphisms and age.

Chromatographic methods with either fluorescent or MS-detection yielded slightly stronger associations than MS-only and multiplexed capillary gel electrophoresis, but at the expense of lower levels of throughput. Advantages and disadvantages of each method were identified, which should inform the selection of the most appropriate method in future studies.