Hengzongshu/ArticleAgent huggingface dataset:
In this study we analyze the applicability of specific machine learning algorithms to the task of detecting sentences containing argumentation in Russian text.

We employ a collection of scientific and popular science texts with manually annotated argumentation to evaluate the quality of identifying argumentative sentences in terms of precision, recall, and F-measure. The experiment involves three algorithms: MNB, SVM, and MLP. The bag of words model is used for representing texts. Lemmas of words in analyzed sentences serve as features for the classification. We perform the automatic selection of informative features in accordance with Variance and χ2 criteria combined with the weight-based filtration of lemmas (via TF*IDF and EMI). The training set includes around 800 sentences, while the test set contains 180.

The MNB algorithm demonstrates the highest F-measure and recall scores on almost all feature sets (maximal values reached equal 68.7% and 89% respectively), while the MLP algorithm shows the best precision for about half of feature selection variations (the maximal value is 72.5%).
Возможность использования тела Гоффа в качестве источника аутологичных стволовых клеток А.В.Корель 1 , И.И.Ким 2 , Е.Л.Строкова 1 , Н.Ю.Пахомова 1 , А.Ф.Гусев 1 , А.М.Зайдман 1 1 Новосибирский НИИ травматологии и ортопедии им.Я.Л.Цивьяна 630091, г.Новосибирск, ул.Фрунзе, 17 2 НИИ клинической и экспериментальной лимфологиифилиал ФИЦ Институт цитологии и генетики СО РАН
The Biochemical Reduction Of Both Nitrate And Sulfate In U-Containing Aquifers Of The Novosibirsk Plant Of Chemical Concentrates (NPCC) Was Investigated Experimentally And Thermodynamically. It Was Observed That Decrease In Eh Up To -397 Mv Has A Distinct Effect On The Denitrification And Uranium Precipitation As UO2(S). Nitrate Was Denitrified With A Temporary Accumulation Of The Intermediate Nitrite On The Day 4th. According To The X-Ray Fluorescence Analysis And Thermodynamic Calculations, More Than Half Of The Uranium Is Deposited In The First Stage As UO2+X oxides, And The Rest, Together With The Sulfides In The Reducing Environment. Findings Suggest That Accurately Thermodynamic Predicting Of Groundwater NO3-; And SO42- Fate Is Primarily Limited By Failing To Account For A Kinetic Of Redox Fluctuations In The Experiment: 1) Measured Eh +190 Mv Is Low Despite The High Amount Of Nitrates (1124 Mg/L), But NH4+ Predominates In Solution According To Calculations, 2) Sulfate Reduction Lagged Behind Nitrate Reduction By Approximately 50 Days Unlike Model Simulation.
There is no doubt that various nanoparticles (NPs) can enter the brain from the nasal cavity. It is assumed that NPs can penetrate from blood into the central nervous system (CNS) only by breaking the blood–brain barrier (BBB). The accumulation of NPs in CNS can provoke many neurological diseases; therefore, the understanding of its mechanisms is of both academic and practical interest. Although hitting from the surface of the lungs into the bloodstream, NPs can accumulate in various mucous membranes, including the nasal mucosa. Thus, we cannot rule out the ability of NPs to be transported from the bloodstream to the brain through the olfactory uptake. To test this hypothesis, we used paramagnetic NPs of manganese oxide (Mn3O4-NPs), whose accumulation patterns in the mouse brain were recorded using T1-weighted magnetic resonance imaging. The effect of intranasal application of endocytosis and axonal transport inhibitors on the brain accumulation patterns of intranasally or intravenously injected Mn3O4-NPs was evaluated. A comparative analysis of the results showed that the transport of Mn3O4-NPs from the nasal cavity to the brain is more efficient than their local permeation through BBB into CNS from the bloodstream, for example with the accumulation of Mn3O4NPs in the dentate gyrus of the hippocampus, and through the capture and transport of NPs from the blood by olfactory epithelium cells. Also, experiments with the administration of chlorpromazine, a specific inhibitor of clathrin-dependent endocytosis, and methyl-β-cyclodextrin, inhibitor of the lipid rafts involved in the capture of substances by endothelium cells, showed differences in the mechanisms of NP uptake from the nasal cavity and from the bloodstream. In this study, we show a significant contribution of axonal transport to NP accumulation patterns in the brain, both from the nasal cavity and from the vascular bed. This explains the accumulation of different sorts of submicron particles (neurotropic viruses, insoluble xenobiotics, etc.), unable to pass BBB, in the brain. The results will add to the understanding of the pathogenesis of various neurodegenerative diseases and help studying the side effects of therapeutics administered intravenously.
Proportional electroluminescence (EL) is the physical effect used in two-phase dark matter detectors, to optically record in the gas phase the ionization signal produced by particle scattering in the liquid phase. In our previous works the presence of a new EL mechanism in noble gases, namely that of neutral bremsstrahlung (NBrS), was demonstrated both theoretically and experimentally, in addition to the ordinary EL mechanism due to excimer emission.

In this work we show that the similar theoretical approach can apply to noble liquids, namely to liquid helium, neon, argon, krypton and xenon. In particular, the photon yields and spectra for NBrS EL in noble liquids have for the first time been calculated, using the electron energy and transport parameters obtained in the framework of Cohen-Lekner and Atrazhev theory.

The relevance of the results obtained to the development of noble liquid detectors for dark matter searches and neutrino experiments is discussed.
tetrapeptide FwKT (Phe-D-Trp-Lys-Thr), which is considered to represent an epitope for biomedically relevant hormone somatostatin

The target molecule was successfully crystalized, solved and refined as a conjugate of the tetrapeptide moiety bearing a protective group DOTA at the N-terminus and methylated at the O-terminus

The combination of a hormone active site and a powerful chelator make the substance a highly prospective targeted drug delivery system, especially for peptide receptor radionuclide therapy (PRRT) applications
The contemporary deep degradation of the Eastern sector of the Russian Arctic in the post-Soviet period requires solutions, as well as the expansion of the impact of the needs of Siberia and its Arctic territories on the Russian and world economic growth. This article aims to explain how the development of the Arctic can become a source of acceleration of social and economic development of Russia — a driver of development and its multiplier. This emphasizes the importance of following the principle of connectivity in the development of the Eastern sector of the Russian Arctic, when analyzing the sources of complexity the design of its development, performed by the employees of the Institute of Economics and Industrial Engineering, Siberian Branch of the Russian Academy of Sciences (IEIE SB RAS). The article studies the projects of integrated development of the Eastern sector of the Arctic zone of Russia, developed in 2015-2018 by the IEIE SB RAS as potential drivers and multipliers that can accelerate the social and economic development of the entire country. The author emphasizes the non-constructive focus of some researchers on the development of a narrowly understood regional perspective of the problems of developing the potential of the Russian Arctic and justifies the need for a systematic approach to its development in the context of global economic ideas. The article reveals the mental sources of the commitment of the research staff of the IEIE SB RAS to system research, to the implementation of the theory of optimal use of limited natural and economic resources in research projects. The possibility of a significant acceleration of economic growth in Siberia and Russia as a whole during the implementation of Arctic projects, provided that the priority participation of industrially developed and densely populated regions of southern Siberia. The article shows that for the formation and implementation of an effective social and economic strategy of secondary (post-industrial) transformation of the Russian society, it is not enough to specify the current and long-term objectives of the economic movement. The authors concludes that it is of fundamental importance to identify potential drivers and multipliers in their composition that can accelerate the social and economic development of the country.
Patients with COVID-19 may develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease, requires further research on the pathogenesis of this disease. Based on the analysis of published data on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of viral particles can enter into the esophagus from nasopharynx. Entering viral particles into the gastrointestinal tract will obviously be accompanied by infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from nasopharynx and intestines to lungs. The model simulations also supposes that sanitation of the nasopharynx mucosa at the initial stage of the infectious process considering inhibition of the virus accumulation by means of cellular and humoral responses has prospects for the use in medicine practice.
We search for lepton-number- and baryon-number-violating decays ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}\overline{p}{e}^{+}{e}^{\ensuremath{-}}$, $p{e}^{\ensuremath{-}}{e}^{\ensuremath{-}}$, $\overline{p}{e}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$, $\overline{p}{e}^{\ensuremath{-}}{\ensuremath{\mu}}^{+}$, $\overline{p}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$, and $p{\ensuremath{\mu}}^{\ensuremath{-}}{\ensuremath{\mu}}^{\ensuremath{-}}$ using $921\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of data, equivalent to $(841\ifmmode\pm\else\textpm\fi{}12)\ifmmode\times\else\texttimes\fi{}{10}^{6}$ ${\ensuremath{\tau}}^{+}{\ensuremath{\tau}}^{\ensuremath{-}}$ events, recorded with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider. In the absence of a signal, 90% confidence-level upper limits are set on the branching fractions of these decays in the range $(1.8\ensuremath{-}4.0)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}8}$. We set the world's first limits on the first four channels and improve the existing limits by an order of magnitude for the last two channels.
Wolbachia is an endosymbiont prevalent among different arthropoda and in some Nematoda species. The bacteria ads across the populations of host species via induction of reproductive abnormalities: cytoplasmic incompatability, parthenogenesis, feminization, and male killing. we estimated the level of cytoplasmic incompatability in Drosophila melanogaster caused by three most prevalent Wolbachia genotypes, namely wmel, wmelCS и wmelCS2. wmel and wmelCS genotypes were shown to cause mild cytoplasmic incompatibility ( 10 %), while wmelCS Wolbachia were unable to do so. Possible mechanisms of sustainability of Wolbachia in the populations of Drosophila melanogaster are discussed.table border="0" cellpadding="3" cellspacing="0" tbody /tbody/table
Specificity of hydrogeological aspects of the Siberian sedimentary basins is most pronounced in their Arctic part where the saltless type the cross section grades into saline type in the direction from the Yamal Peninsula (as part of the West Siberian sedimentary basin), passing through the Yenisei-Khatanga basin as far as the Anabar-Khatanga basin with salt domes in its structure. It has been established that the modern chemistry of groundwaters and brines of petroleum-bearing deposits is a product of long-term geological evolution affected by many geological and hydrogeological factors. Slightly metamorphosed groundwaters and weak brines of sodium chloride, chloride-bicarbonate sodium and sodium bicarbonate-chloride composition, with the TDS value varying from 2 to 63.3 g/dm3 (after S. A. Shchukarev) are widely developed within the West Siberian and the Yenisei-Khatanga basins. Subsurface brines from the areas adjacent to the Anabar-Khatanga basin are found to be dominantly sodium chloride in composition, with TDS value varying from 52.3 to 312.3 g/dm3, while those identified in the adjacent areas of the Siberian platform are strongly metamorphosed, of sodium chloride, sodium-calcium and calcium composition, with the TDS value up to 480 g/dm3. Results of the detailed hydrogeochemistry analysis of petroleum reservoirs and paleohydrological history of Arctic parts of the Siberian sedimentary basins have prompted the presence of three genetic groups of subsurface waters in their section: infiltrogenic, sedimentogenic and condensatogenic. The first group includes modern and ancient infiltrogenic waters and brines resulting from salt domes leaching; the second group is composed of sedimentogenic waters (including brines), lithogenic waters and cryopegs. Comprising condensatogenic waters formed syngenetically with the hydrocarbon pools, the third group represents a special type, since the "water-rock-gas-organic matter" system has largely affected the processes of formation of their chemical composition.
We consider thermochemical mantle plumes with thermal power 1.6·1010 W< N <2.7·1010 W (relative thermal power 1.15<Ka<1.9) as plumes with an intermediate thermal power. Such plumes are formed at the core–mantle boundary beneath cratons in the absence of horizontal free‐convection mantle flows beneath them, or in the presence of weak horizontal mantle flows. A proposed scheme of convection flows in the conduit of a plume with an intermediate thermal power is based on laboratory and theoretical modeling data. A plume ascends (melts out) from the coremantle boundary to critical depth x кр from which magma erupts on the Earth’s surface. The magmatic melt erupts from the plume conduit onto the surface through the eruption conduit. The latter forms under the effect of superlithostatic pressure on the plume roof. While the thickness of the block above the plume roof decreases to a critical value x кр, the shear stress on its cylindrical surface reaches a critical value (strength limit) τкр.Rock fails in the vicinity of the cylindrical block and, as a consequence, the eruption conduit is formed. We estimate the height of the eruption conduit and the time for the plume to ascent to the critical depth x кр. The volume of erupted melt is estimated for kinematic viscosity of melt =0.5–2 м2/с. The depth Δ x from which the melt is transported to the surface is determined. Using the eruption volume, we obtain a relationship between the depth Δ x and the plume conduit diameter for the above‐mentioned kinematic viscosities. In the case that the depth Δ x is larger than 150 km, the melt from the plume conduit can transport diamonds to the Earth’s surface. Thus, the plumes with an intermediate thermal power are diamondiferous. The melt flow structure at the plume conduit/eruption conduit interface is determined on the basis of the laboratory modeling data. The photographs of the simulated flow were obtained. The flow line velocities were measured in the main cylindrical conduit (plume conduit) and at the main conduit/eruption conduit interface. A stagnant area is detected in the 'conduit wall/plume roof’ interface zone. The melt flow in the eruption conduit was analyzed as a turbulent flow in the straight cylindrical conduit with diameter d к. According to the experimental modeling and theoretical data, the superlithostatic pressure in the plume conduit is the sum of the frictional pressure drop and the increasing dynamic pressure in the eruption conduit. A relationship between the melt flow velocity in the eruption conduit and superlithostatic pressure has been derived.
In this article, the author proposes a method for the consistent acquaintance of Russian students studying the Japanese language by way of zoonymes and zoomorphic metaphors based on the example of the transcription of Aesop’s fable “The Dragonfly and the Ant”. In the Japanese transcription, instead of the zoonyme “dragonfly”, another zoonyme “grasshopper” is used. In addition, in Japanese linguistic culture, there are two versions of the fable. In one version, the ants refuse to help the grasshopper, and he dies. In another version, the ants help the grasshopper, and he lives through the winter with the ants and plays the violin. A type of entertainment that has existed for a long time in traditional Japanese culture is to listen to the sounds of insects. In modern-day Japan, there is a subculture of kirigirisu, the culture of street musicians, which entertain listeners. Besides, some even choose cosplay costumes in order to dress up as a grasshopper. The teaching method consists of several stages: - Introduction of a zoonyme (its meanings and spelling options); - Explanation of its significance in Japanese linguistic culture; - Descriptions of associations connected with this zoonyme in Japanese linguistic culture; - The use of the zoonyme in its direct meaning; - The use of the zoonyme as a metaphor in phrases, sentences and proverbs. The teaching of zoonymes and zoomorphic metaphors has both an applied and theoretical significance. In applied terms, it will help students who study Japanese learn more about Japanese linguistic culture; to get acquainted with the legends and traditions connected with these insects; to understand the associations that exist in Japanese society in connection with these insects; to learn the use of zoonymes in direct and figurative meanings in phrases and sentences, as well as to understand idioms in which the names of the insects are used. In theoretical terms, learning zoonymes will help students to understand Japanese linguistic culture and the essence of metaphorical meanings on the basis of examples of a non-native language. The proposed method can be used to get acquainted with any zoonymes and zoomorphic metaphors.
The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed. Different problems concerning the methods and implementation of the ODN synthesis are outlined depending on goals of using target oligomers.
Wilson's disease is a rare autosomal recessive disorder of copper metabolism. The copper accumulation in the viscera appears due to the functional impairment of copper-transporting ATPase, which is encoded by the ATP7B gene. In this study, PBMCs of a patient with two ATP7B mutations were reprogrammed. The first mutation is a missense mutation p.H1069Q, which is the most frequent mutation in the human population. At the same time, the second one is a frameshift mutation p.Lys1013fs. The generated iPSC line had a normal karyotype, maintained the original genotype, expressed pluripotency markers, and demonstrated the ability to differentiate into derivatives of the three germ layers.
Due to their high optical damage threshold, borate crystals can be used for the efficient nonlinear down-conversion of terawatt laser radiation into the terahertz (THz) frequency range of the electromagnetic spectrum. In this work, we carried out a thorough study of the terahertz optical properties of the lithium tetraborate crystal (Li2B4O7; LB4) at 295 and 77 K. Approximating the terahertz refractive index in the form of Sellmeier’s equations, we assessed the possibility of converting the radiation of widespread high-power laser sources with wavelengths of 1064 and 800 nm, as well as their second and third harmonics, into the THz range. It was found that four out of eight types of three-wave mixing processes are possible. The conditions for collinear phase matching were fulfilled only for the o − e → o type of interaction, while cooling the crystal to 77 K did not practically affect the phase-matching curves. However, a noticeable increase of birefringence in the THz range with cooling (from 0.12 to 0.16) led to an increase in the coherence length for o − o → e and e − e → e types of interaction, which are potentially attractive for the down-conversion of ultrashort laser pulses.
The article is devoted to the 60-year history of the Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences. The main stages of its development are considered. This institute was organized as part of the first multidisciplinary Novosibirsk Scientific Center in Siberia. Initially, the Institute was created as an academic base for the study of thermal-hydraulic processes in the atomic power industry that intensively developed in the middle of the 20th century. Over time, other promising areas of scientific research were added. Currently, the Kutateladze Institute of Thermophysics SB RAS is one of the leading scientific centers on the theory of heat transfer and physical hydrodynamics. The article shows the main results of eminent scientists of the Institute.
A search for radiative decays of the P-wave spin singlet charmonium resonance h_{c} is performed based on 4.48×10^{8} ψ^{'} events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels h_{c}→γη^{'} and γη are observed with a statistical significance of 8.4σ and 4.0σ, respectively, for the first time. The branching fractions of h_{c}→γη^{'} and h_{c}→γη are measured to be B(h_{c}→γη^{'})=(1.52±0.27±0.29)×10^{-3} and B(h_{c}→γη)=(4.7±1.5±1.4)×10^{-4}, respectively, where the first errors are statistical and the second are systematic uncertainties.
The classification, up to isomorphism, of all self-embedding monomial power permutations of Hamming Steiner triple systems of order n=2^m-1 for small m, m < 23, is given.

As far as we know, for m in {5,7,11,13,17,19}, all given self-embeddings in closed surfaces are new. Moreover, they are cyclic for all m and nonorientable at least for all m < 21.

For any non prime m, the nonexistence of such self-embeddings in a closed surface is proven.
The use of artificial data to evaluate the performance of aligners and peak callers not only improves its accuracy and reliability, but also makes it possible to reduce the computational time. One of the natural ways to achieve such time reduction is by mapping a single chromosome. We investigated whether a single chromosome mapping causes any artefacts in the alignments’ performances. In this paper, we compared the accuracy of the performance of seven aligners on well-controlled simulated benchmark data which was sampled from a single chromosome and also from a whole genome. We found that commonly used statistical methods are insufficient to evaluate an aligner performance, and applied a novel measure of a read density distribution similarity, which allowed to reveal artefacts in aligners’ performances. We also calculated some interesting mismatch statistics, and constructed mismatch frequency distributions along the read. The generation of artificial data by mapping of reads generated from a single chromosome to a reference chromosome is justified from the point of view of reducing the benchmarking time. The proposed quality assessment method allows to identify the inherent shortcoming of aligners that are not detected by conventional statistical methods, and can affect the quality of alignment of real data.