Hengzongshu/ArticleAgent huggingface dataset:
Mechanical treatment of dry powder mixtures has often been reported to give new compounds. The assumption of neat mechanochemical conditions must, however, be made with caution even if the reactants are not crystal hydrates. The fluidised intermediate, which is often necessary for mechano-co-crystallisation of organic molecules, can readily form by interaction with atmospheric moisture.

We illustrate this using "dry" mechanochemical synthesis of glycinium semi-malonate as an example. The α-glycine and malonic acid mixture is shown to be highly hygroscopic, which can be largely accredited to the hygroscopicity of malonic acid.

Dissolution in atmospheric moisture is sufficient for the spontaneous crystallisation of the salt product. This is a prime example where liquid is both necessary for mechanosynthesis, while simultaneously hindering the reaction by affecting the rheology of the mixture: Liquid Hindered Grinding. These results shed new light on possible sources of regional, seasonal and temperature effects on mechanosynthesis, as well as a potential role for polymer additives.
Eddy currents in a constriction placed in a two-dimensional electron gas (2DEG) have been experimentally studied. The constrictions fabricated by the electron-beam lithography demonstrate quantum Hall effect in high magnetic field. Pronounced hysteresis of magnetoresistance is observed at Hall plateaus corresponding to integer filling factors v = 1, 2 and 4 of a macroscopic 2DEG. The dependence of magnetoresistance hysteresis on the constriction width is obtained. The dependence contains the threshold value of width that points to the edge nature of eddy currents and enables us to determine the eddy currents area width, which is about 0.5 μm.
Detection of perspective research areas in academic studies is of key importance for successful development and enhancement of the competitive performance of research organizations, universities, and the country. This task is usually solved by the expert community; however, the use of results of bibliometric analysis can give significant support to experts for informed decisions. The paper uses a case study of Earth Sciences to present a bibliometric model for the detection of perspective research in individual research organizations. The model is based on multiplex analysis of publications from the analyzed organization using content analysis and citation analysis.
The search for lipid-lowering drugs is important for clinical medicine. There are several validated agents altering lipid levels which reduce the risk of atherosclerotic cardiovascular events. Nonetheless, for many people, the risk of such an event remains unacceptably high despite treatment with these agents. This situation has prompted the search for new therapies to reduce the residual cardiovascular risk.

This review summarizes our research findings regarding the hypolipidemic activity of polysaccharides. The lipid-lowering effect of β-glucans consumed with food was demonstrated in patients with atherosclerosis. The mechanism of the protective effect of β-glucans is poorly studied. The effects of β-glucans are mediated by Toll-like receptors, by dectin-1, and possibly by other receptors. Nevertheless, the mechanism of the protective action of β-glucan in lipemic mice has been studied insufficiently. It has been reported that, in mice, chitin particles of certain size are recognized by macrophages through Toll-like receptors, dectin-1, and to a lesser extent through mannose receptor.

This review will present up-to-date information regarding experimental hypolipidemic polysaccharide compounds that hold promise for medicine. Phagocyte-specific chitotriosidase in humans contributes to innate immune responses against chitin-containing fungi. This enzyme has been first described in patients with Gaucher disease and serves as an important diagnostic biomarker.
Aim. To establish associations of the prevalence of ischemic heart disease (IHD) and factors of psychoemotional stress in men of the open urban population in the age group 4564 years after two decades of life.

Materials and methods. A cross-sectional epidemiological study using a model of the city of Tyumen was conducted on a representative sample of the population among males of mature age (4564 years). Based on standard epidemiological methods, IHD was established according to strict epidemiological criteria definite IHD. The study of the factors of psycho-emotional stress (depression, hostility, life exhaustion) was carried out according to the algorithms of the World Health Organization program MONICA-psychosocial. When calculating the odds ratio for the development of IHD, a low level of psycho-emotional stress factors was regarded as the absence of a sign, a combination of medium and high levels as a presence.

Results. The prevalence of ischemic heart disease in the open population (on the model of Tyumen) according to strict epidemiological criteria in men aged 4554 years was 8.2%, at the age of 5564 years 19.2%, a predominance of painless form of ischemic heart disease was revealed. According to the levels of factors of psychoemotional stress in mature men, mainly the average level of depression and life exhaustion, a high level of hostility were established. In men of an open population (on the model of Tyumen), depending on the psychoemotional stress, a high risk of developing a certain coronary heart disease was established in the age categories 4554 and 5564 years old in the presence of depression, at the age of 5564 years in the presence of hostility or life exhaustion. Conclusion. Consequently, the data obtained indicate the importance of further studying the factors of psychoemotional stress in men of mature age in Siberian populations, their relationships with conventional risk factors for coronary artery disease, as well as the advisability of preventive measures aimed at weakening the influence of not only conventional risk factors, but also factors of psycho-emotional stress. among the Russian population.
Experimental and numerical studies of spatiotemporal femtosecond soliton propagation over up to 1 km spans of parabolic graded-index fibers reveal that initial multimode soliton pulses naturally and irreversibly evolve into a single-mode soliton.

This is carried by the fundamental mode of the fiber, which acts as a dynamical attractor of the multimode system for up to the record value (for multimode fibers) of 5600 chromatic dispersion distances.

This experimental evidence invalidates the use of variational approaches, which intrinsically require that the initial multimode propagation of a self-imaging soliton is indefinitely maintained.
This paper addresses a new real-world application of vehicle routing planning in a finite time horizon. A company in the small package shipping industry has a limited fleet of identical vehicles in some depots and must serve a set of clients. There is a frequency for each client stating how often this client must be visited. Time intervals between two consecutive visits must be the same but the visiting schedule is flexible. To get some competitive advantage, a company tries to increase the service quality. To this end, each client should be visited by one driver only. The goal is to minimize the total traveling distance for all vehicles over the planning horizon under the frequency constraints and driver shift length constraints. We present an integer linear programming model for this new consistent vehicle routing problem. To find near optimal solutions, we design the Variable Neighborhood Search metaheuristic with nine neighborhood structures. The driver shift length constraints are penalized and included in the objective function. Empirical results for real test instances from Orenburg region in Russia with up to 900 clients and four weeks in the planning horizon are discussed.
Ornithine aminotransferase (OAT) catalyzes transfer of the delta-amino group from L-ornithine to oxo-glutarate. In plants, this reaction biochemically connects urea cycle, proline cycle, and polyamine biosynthesis pathway. OAT activity is shown to be associated with biotic and abiotic stress responses and nitrogen metabolism, but its physiological role is still unclear.

In our study, we decided to investigate transcriptional regulation of the OAT gene in Arabidopsis thaliana under normal conditions and in response to various growth regulators. In the present work, the reporter gene construct containing the Escherichia coli β-glucuronidase gene (gus) under control of the A. thaliana OAT gene promoter was introduced into the genome of A. thaliana ecotype Columbia plants using the floral dip method; GUS activity was assayed in different experimental conditions including hormone treatment, low and high nitrogen and salinity. The GUS activity was analyzed histochemically. Plants were incubated with staining solution containing X-Gluc.

We show that under standard growth conditions, the promoter is active during germination and in developing floral organs. OAT promoter activity specifically activates in response to different forms of auxin (IAA, NAA, and 2,4D), cytokinin (6- BAP), ethylene precursor (ACC), high nitrogen and salinity. Analysis of the OAT expression by qRT-PCR confirmed the pattern observed using the GUS reporter system. The OAT gene showed a significantly elevated expression in fourday- old seedlings and in plant roots in response to auxins and cytokinins. The analysis of the OAT promoter structure reveals cis-acting regulatory DNA elements associated with auxin regulation and abiotic stresses. The results of the study indicate that the OAT gene is involved in developmental processes and is regulated by auxin and cytokinins.
Nifedipine is calcium channels and pumps blocker widely used in medicine. However, mechanisms of nifedipine action in blood are not clear. In particular, the influence of nifedipine on erythrocytes is far from completely understood.

In this work, applying scanning flow cytometry, we observed experimentally for the first time the dynamics behind a significant increase of HCO 3 − /Cl − transmembrane exchange rate of CDB3 (main anion exchanger, AE1, Band 3, SLC4A1) of human erythrocytes in the presence of nifedipine in blood. It was found that the rate of CDB3 activation is not limited by the rate of nifedipine binding and/or Ca 2+ transport. In order to explain the experimental data, we suggested a kinetic model assuming that the rate of CDB3 activation is limited by the dynamics of the balance between two intracellular processes (1) the activation of CDB3 limited by its interaction with intracellular Ca 2+ , and (2) the spontaneous deactivation of CDB3.

Thus the use of scanning flow cytometry allowed to clarify quantitatively the molecular kinetic mechanism of nifedipine action on human erythrocytes. In particular, the efficiency (~30) and rates of activation (~0.3 min −1 ) and deactivation (~10 −3 min −1 ) of CDB3 in human erythrocytes was evaluated for two donors.
The AWAKE Collaboration has been formed in order to demonstrate proton-driven plasma wakefield acceleration for the first time. This acceleration technique could lead to future colliders of high energy but of a much reduced length when compared to proposed linear accelerators.

The CERN SPS proton beam in the CNGS facility will be injected into a 10 m plasma cell where the long proton bunches will be modulated into significantly shorter micro-bunches. These micro-bunches will then initiate a strong wakefield in the plasma with peak fields above 1 GV/m that will be harnessed to accelerate a bunch of electrons from about 20 MeV to the GeV scale within a few meters. The experimental program is based on detailed numerical simulations of beam and plasma interactions. The main accelerator components, the experimental area and infrastructure required as well as the plasma cell and the diagnostic equipment are discussed in detail.

First protons to the experiment are expected at the end of 2016 and this will be followed by an initial three-four years experimental program. The experiment will inform future larger-scale tests of proton-driven plasma wakefield acceleration and applications to high energy colliders.
Possibility of large bodies formation in massive discs of young stellar objects (YSO) class O-I was investigated. On the stage of YSO O-I the whole of factors: chemical composition of gas and solids, chemical catalytic reactions, the disc self-gravitation, the increased ratio of solids to gas surface density, adiabatic gas cooling provides favorable conditions for gravitational instabilities development. We simulated 3D dynamics of gas and dust under self-consistent gravitational field and reproduced the formation and evolution of the disc around the protostar. We found that for stars of Solar mass there are regimes when the disc of variable mass is unstable for the development of fast gravitational instabilities.
A study is made on the previously ignored problem of the dependence of a static fluorescence quenching Stern-Volmer constant Ksv on the initial concentration of [F]0 fluorophore F. This correlation is shown to exist. It is concluded that the Stern-Volmer quenching constant may be used as association constant K only with .
Many neurodegenerative diseases, including Huntington’s disease (HD), are associated with oxidative stress in the neurons of the brain. Genetically encoded biosensorsare useful for studying these processesin vitro. Human cell cultures expressing the biosensors can serve as a cell model for developing and testing effective agents that reduce oxidative stress. In this work, transgenes encoding biosensors of glutathione oxidative potential(Grx1-roGFP2) with cytoplasmic and mitochondrial localization were introduced into human induced pluripotent stem cells of a healthy donor and an HD patient using CRISPR/Cas9-mediated genome editing. The cells were subsequently differentiated into medium spiny neurons of the striatum. The expression of the biosensors was detected in the iPSCs, neuronal precursors and mature neurons.The obtained cells could be used to study the redox potential of glutathione in HD neurons and to screen for new drug compounds aimed at reducing oxidative stress. Keywords: genetically encoded biosensors, Huntington’s disease, induced pluripotent stem cells, medium spiny neurons, oxidative stress, glutathione, Grx1-roGFP2
Passive mode locking based on the effect of non-linear polarisation evolution

achieved through a polarisation controller containing a single low-voltage liquid crystal plate whose optimal wave delay was determined from analysis of inter-mode beat spectrum of the output radiation

The present work demonstrates a fibre-laser system with automatic electronic-controlled triggering of dissipative soliton generation mode
The article is devoted to the study of the status of intensionality in the exact contexts of logical and mathematical theories. The emergence of intensionality in logical and mathematical discourse leads to significant obstacles in its formalization due to the appearance of indirect contexts, the uncertainty of its indication in the theoretical apparatus, as well as the presence of various kinds of difficult-to-account semantic distinctions. The refusal to consider intensionality in logic is connected with Bertrand Russell’s criticism of Alexius Meinong’s intensionality ontology, and with Willard Van Orman Quine’s criticism of the concept of meaning and quantification of modalities. It is shown that this criticism is based on a preference for the theory of indication over the theory of meaning, in terms of the distinction “Bedeutung” and “Sinn” introduced by Gottlob Frege. The extensionality thesis is explicated; by analogy with it the intensionality thesis is constructed. It is shown that complete parallelism is not possible here, and therefore we should proceed from finding cases of extensionality violation. Since the construction of formal logical systems is to a certain extent connected with the programs of the foundations of mathematics, the complex interweaving of philosophical and purely technical questions makes the question of the role of intensionality in mathematics quite confusing. However, there is one clue here: programs in the foundations of mathematics have given rise to metamathematics, which, although it stands alone, is considered a branch of mathematics. It is not by chance that, judging by the problems arising in connection with intensionality, there is a growing suspicion that intensionality can play a significant role in metamathematics. As for the question of the sense in which metamathematics results can be considered mathematical, in terms of the presence of intensional contexts in both disciplines, it is a matter of taste: for example, the autonomy of mathematical knowledge as a result of the desire of mathematicians to eliminate the influence of philosophy that took place in the case of David Hilbert may be worth considering in the context of mathematics. Thus, the rather vague concept of intensionality receives various explications in different contexts, whether it is philosophical logic or metamathematics. In any case, the detection of context intensionality is always associated with a clear narrowing of the research area. It is obvious that the creation of a more general theory of intensionality is possible within a more general framework, in which logic and mathematics must be combined. In this respect, we can hope for the resumption of a logical project, which would be a purely logical consideration made of the natural and the mathematical.
This article is devoted to detailed experimental studies of the flow behind the impeller of an air model of a propeller-type microhydroturbine in a wide range of operating parameters.

The measurements of two component distributions of averaged velocities and pulsations for conditions from part load to strong overload are conducted.

It is shown that the flow at the impeller outlet becomes swirled when the hydraulic turbine operating mode shifts from the optimum one. The character of the behavior of the integral swirl number, which determines the state of the swirled flow, is revealed. Information about the flow peculiarities can be used when adjusting the hydraulic unit mode to optimal conditions and developing recommendations to expand the hydraulic turbine operation control range with preservation of high efficiency. This stage will significantly save time at the stage of equipment design for specific field conditions of water resource.
In this work we derive conditions under which a level-crossing line in a magnetic field effect curve for a recombining radical pair will be equivalent to the electron spin resonance (ESR) spectrum

and discuss three simple rules for qualitative prediction of the level-crossing spectra.
We previously showed that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 alleviates motor manifestations of Parkinson's disease in animal models. In the present study, we designed and synthesized monoepoxides of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 and evaluated their biological activity in the MPTP mouse model of Parkinson's disease. We also assessed the ability of these compounds to penetrate the blood–brain barrier (BBB). According to these data, we chose epoxide 4, which potently restored the locomotor activity in MPTP-treated mice and efficiently penetrated the BBB, to further explore its potential mechanism of action. Epoxide 4 was found to robustly promote the survival of cultured dopamine neurons, protect dopamine neurons against toxin-induced degeneration, and trigger the mitogen-activated protein kinase (MAPK) signaling cascade in cells of neuronal origin. Meanwhile, neither the survival-promoting effect nor MAPK activation was observed in non-neuronal cells treated with epoxide 4. In the MPTP mouse model of Parkinson's disease, compound 4 increased the density of dopamine neuron fibers in the striatum, which can highlight its potential to stimulate striatal reinnervation and thus halt disease progression. Taken together, these data indicate that epoxide 4 can be a promising compound for further development, not only as a symptomatic but also as a neuroprotective and neurorestorative drug for Parkinson's disease.
Halorubrum sp. strain 48-1-W was isolated from a water sample from a saline lake (Novosibirsk Region, Russia, 54°14'N 78°13'E). The sequenced and annotated genome is 3,584,929 bp and contains 3,506 genes.
This work presents the design and characteristics of the 700-kilovolt pulsed X-ray apparatus, based on a principally new electro-physical structure. The main idea of this structure is that Blumlein pulse-forming system (transmission line, PFL), the primary and secondary circuit inductances and the capacitance of the secondary circuit of the Tesla transformer, running in the first half-wave occupy the same volume in space and do not impede each other. This kind of circuit design and the packing density as related to the pulse output dose is unrivalled throughout the world. The dependences of dose on the forming line voltage, and the flash duration on the different apparatus construction are measured.
This article reflects the results of studying the infographics on the sites of large cities in Siberia – the second stage of infographics studying in regional media, specifically of the most cited Internet mass media of Krasnoyarsk and Omsk cities with a population of over 1 million people in the Siberian Federal District. During the first stage it was shown how this format was developed chronologically and how many infographics were published on these sites over the years.

At the second stage of the study, the content analysis method and the typological method were applied to the generated empirical database, and the audience indicators of the respective projects were analyzed.

As a result, the article provides quantitative characteristics of different types of infographics. The typology was carried out for various reasons: autonomy from the accompanying text, interactivity, type of presentation of data (processes, objects), which corresponds to the created information graphics. The text also describes the various editorial features of creating infographics in seven analyzed online media, answers to questions: do the editors create their own infographics or borrow it for information or advertising purposes, which topics are visualized in this way, what data sources are used, in which programs do they work and etc. And the analysis of audience indicators allows us to conclude whether the presence of infographics in the text helps to increase the number of readings.
Приводятся данные литологического, спорово-пыльцевого и радиоуглеродного анализов отложений массива дюнных песков - тукулан Кысыл-Сырский (долина нижнего течения р. Вилюй, Центральная Якутия).

На основании полученных результатов в районе исследования выделены три этапа развития растительности и три стадии формирования тукулана Кысыл-Сырский

за последние 40 тыс. лет.
The paper discusses the results of an experimental study of the propagation of the "N-wave" in a supersonic flow and its interaction with the bow shock wave, which is formed at flowing around a flat plate with a sharp leading edge.

Estimates of the propagation angles of the "N-wave" in a supersonic flow are also obtained.

It was found that the "N-wave" does not change its direction when interacting with the bow shock. However, this interaction leads to a reduction of the "N-wave".