Hengzongshu/ArticleAgent huggingface dataset:
The article is devoted to the development of new knowledge generation methods based on the analysis of natural language texts. To extract knowledge from natural language texts, the method of presenting sentences in the form of binary predicates with new constant-situation is used. For the representation of knowledge in a formal form, we use quantifier-free sentences of predicate logic, as well as the OWL DL language. The generation of new knowledge is realized with the help of reasoners, using pre-defined patterns of inference rules. A software system has been developed that allows users to get answers to specific questions related to given natural language texts. The answers are built in a natural language, using not only the knowledge that is explicitly contained in the document being processed, but also the knowledge generated by the reasoners.
655 nm laser radiation with power of >60 mW is generated by frequency doubling of a broadband randomly-polarized 1.31-microm Raman fiber laser (RFL).

The red power appears to grow linearly with increasing RFL power up to 7 W at efficiency comparable with that for single-frequency lasers.

It has been shown that multiple sum-frequency mixing processes involving different RFL modes provide the main contribution to the output, which is enhanced by 2 times due to the modes stochasticity.
SUMMARY We investigated the first laboratory-confirmed human case of cowpox virus infection in Russia since 1991. Phylogenetic studies of haemagglutinin, TNF- α receptor-like protein and thymidine kinase regions showed significant differences with known orthopoxviruses, including unique amino-acid substitutions and deletions. The described cowpox virus strain, taking into account differences, is genetically closely related to strains isolated years ago in the same geographical region (European part of Russia and Finland), which suggests circulation of viral strains with common origin in wild rodents without spread over long distances and appearance in other parts of the world.
In this work we describe simulation and experimental studies of the possible reasons for the observed increase of the maximum gain in multi-GEM devices. Two main hypotheses are analyzed: first, a diffusion-dominated charge spread reducing the density in individual holes, acting as independent amplifiers and therefore an increase of the discharge limit with the number of cascaded electrodes; second, the possibility that total avalanche charge before transition to a discharge (Raether limit) strongly depends on the field value and is therefore much higher in cascaded than in single-stage systems.
The work on automated testing of programming tasks had been held in Novosibirsk State University since 1998. It was created several generations of systems of this type. The first program of about 1,000 lines was written in Perl. The article also provides an overview of the existing systems for checking tasks on programming, an analysis of the advantages and disadvantages of each of these systems.

Currently, the automated system, named NSUts, is used in the programming contests and in the educational process. As a result of work in it, as well as acquaintance with other similar systems, both Russian and foreign, it was possible to formulate requirements for software development of this kind, to analyze the difference between the systems for testing competitions and training support systems. The current state of the NSUts system architecture is described.

Much attention is paid to the practice of using the system in the educational process, statistics and graphs of students' progress of students studying with the help of this system are given. The article describes the analysis of the experience of using the NSUts system and outlines the prospects for its development.
A systematic computational study focused on searching for the global minima and low‐lying isomers of the Li 4 E 8 (E = P, As, Sb, Bi) series of clusters is reported. The global‐minimum structures of Li 4 P 8 , Li 4 As 8 , and Li 4 Sb 8 as well as one of the lowest‐lying Li 4 Bi 8 isomers were found to contain a realgar‐type [E 8 ] 4– unit, which is a rare Zintl anion. Increased stability of this skeleton allows its presence to be expected in more complex chemical compounds containing group 15 elements with appropriate stoichiometry.
To meet new trigger and data acquisition (TDAQ) buffering requirements and withstand the high expected radiation doses at the High-Luminosity LHC, the ATLAS Liquid Argon Calorimeter readout electronics will be upgraded. The triangular calorimeter signals are amplified and shaped by analog electronics over a dynamic range of 16 bits, with low noise and excellent linearity. Developments of low-power preamplifiers and shapers in the 130 nm CMOS technology are ongoing to meet these requirements. In order to digitize the analog signals on two gains after shaping, a radiation-hard, low-power 40 MHz 14-bit Analog-to-Digital Converter (ADC) is developed using a pipeline + Successive Approximation Register (SAR) architecture in the 65 nm CMOS technology. Characterization of the prototypes of the front-end components show good promise to fulfill all the requirements. The signals will be sent at 40 MHz to the off detector electronics, where Field-Programmable Gate Arrays (FPGAs) connected through high-speed links will perform energy and time reconstruction through the application of corrections and digital filtering. Reduced data will be sent with low latency to the first level trigger, while the full data will be buffered until the reception of trigger accept signals. The data-processing, control and timing functions will be realized by dedicated boards connected through Advanced Telecommunications Computing Architecture (ATCA) crates.
Obesity affects quality of life and life expectancy and is associated with cardiovascular disorders, cancer, diabetes, reproductive disorders in women, prostate diseases in men, and congenital anomalies in children. The use of single nucleotide polymorphism (SNP) markers of diseases and drug responses (i.e., significant differences of personal genomes of patients from the reference human genome) can help physicians to improve treatment. Clinical research can validate SNP markers via genotyping of patients and demonstration that SNP alleles are significantly more frequent in patients than in healthy people. The search for biomedical SNP markers of interest can be accelerated by computer-based analysis of hundreds of millions of SNPs in the 1000 Genomes project because of selection of the most meaningful candidate SNP markers and elimination of neutral SNPs. We cross-validated the output of two computer-based methods: DNA sequence analysis using Web service SNP_TATA_Comparator and keyword search for articles on comorbidities of obesity. Near the sites binding to TATA-binding protein (TBP) in human gene promoters, we found 22 obesity-related candidate SNP markers, including rs10895068 (male breast cancer in obesity); rs35036378 (reduced risk of obesity after ovariectomy); rs201739205 (reduced risk of obesity-related cancers due to weight loss by diet/exercise in obese postmenopausal women); rs183433761 (obesity resistance during a high-fat diet); rs367732974 and rs549591993 (both: cardiovascular complications in obese patients with type 2 diabetes mellitus); rs200487063 and rs34104384 (both: obesity-caused hypertension); rs35518301, rs72661131, and rs562962093 (all: obesity); and rs397509430, rs33980857, rs34598529, rs33931746, rs33981098, rs34500389, rs63750953, rs281864525, rs35518301, and rs34166473 (all: chronic inflammation in comorbidities of obesity). Using an electrophoretic mobility shift assay under nonequilibrium conditions, we empirically validated the statistical significance (α < 0.00025) of the differences in TBP affinity values between the minor and ancestral alleles of 4 out of the 22 SNPs: rs200487063, rs201381696, rs34104384, and rs183433761. We also measured half-life (t1/2), Gibbs free energy change (ΔG), and the association and dissociation rate constants, ka and kd, of the TBP-DNA complex for these SNPs. Validation of the 22 candidate SNP markers by proper clinical protocols appears to have a strong rationale and may advance postgenomic predictive preventive personalized medicine.
This paper by the example of spent automobile transmission oil investigates the combustion of sub-standard liquid hydrocarbons in a straight-flow burner, implementing a promising method of liquid fuel dispersion by a superheated steam jet.

The aim of the work is to study the influence of regime parameters on the thermal and environmental characteristics of the combustion process. Gas composition of combustion and heat release products was measured. A flow calorimeter was used to measure heat release. The measurement of the amount of generated heat was based on determining the coolant temperature difference at the inlet and outlet as well as the flow rate of the coolant and fuel under stationary experimental conditions. TESTO 350 gas analyzer was used to control the composition of gaseous combustion products. Sampling of reaction products cooled to room temperature was carried out at the calorimeter output.

Dependences of specific heat release on steam and fuel flow rates have been obtained. The regimes with low CO content in the combustion products have been found.
Earlier, after our bioinformatic analysis of single-nucleotide polymorphisms of TATA-binding protein-binding sites within gene promoters on the human Y chromosome, we suggested that human reproductive potential diminishes during self-domestication.

Here, we implemented bioinformatics models of human diseases using animal in vivo genome-wide RNA-Seq data to compare the effect of co-directed changes in the expression of orthologous genes on human reproductive potential and during the divergence of domestic and wild animals from their nearest common ancestor (NCA). For example, serotonin receptor 3A (HTR3A) deficiency contributes to sudden death in pregnancy, consistently with Htr3a underexpression in guinea pigs (Cavia porcellus) during their divergence from their NCA with cavy (C. aperea).

Overall, 25 and three differentially expressed genes (hereinafter, DEGs) in domestic animals versus 11 and 17 DEGs in wild animals show the direction consistent with human orthologous gene-markers of reduced and increased reproductive potential. This indicates a reliable association between DEGs in domestic animals and human orthologous genes reducing reproductive potential (Pearson’s χ2 test p < 0.001, Fisher’s exact test p < 0.05, binomial distribution p < 0.0001), whereas DEGs in wild animals uniformly match human orthologous genes decreasing and increasing human reproductive potential (p > 0.1; binomial distribution), thus enforcing the norm (wild type).
The Mongol–Okhotsk Belt, the youngest segment of the Central Asian Orogenic Belt, formed by the evolution and closure of the Mongol–Okhotsk Ocean. The oceanic closure formed two volcanoplutonic belts: Selenge Belt in the north and Middle Gobi Belt in the south (in present day coordinates). However, the origin and tectonic evolution of the Mongol–Okhotsk Belt in general, the origin and formation age of the Middle Gobi Belt in particular, remain enigmatic. To better understand the history of the magmatic activity in the Middle Gobi Belt, we conducted geochemical, U–Pb geochronological, zircon Hf, whole-rock Nd isotopic analyses of volcanic and plutonic rocks of the Mandalgovi suite, the major component of the Middle Gobi Belt. Our results show that the Mandalgovi suite consists of (i) 265 ± 2 Ma biotite-granite; (ii) 250 ± 3 Ma hornblende-granitoids; (iii) their volcanic equivalents of both: and (iv) gabbro-diorites. The geochemical compositions indicate that their precursor magmas were derived from crustal source. The protoliths of the biotite and hornblende-granitoids were metagraywacke and metabasalt, respectively. They are characterized by positive whole-rock εNd(t) and zircon εHf(t) values, indicating the molten protoliths were juvenile crust. The biotite-granites formed by remelting of fore-arc sediments by ridge subduction and later hornblende-granites were emplaced at an intra-oceanic arc by the subduction of the Mongol–Okhotsk Ocean. We conclude that the magmatic rocks of the Middle Gobi formed in an active continental margin and/or intra-oceanic arc setting.
We examined methods of controlling the pulse duration, spectral width and wavelength of the output from an all-fiber Yb laser mode-locked by carbon nanotubes.

It is shown that a segment of polarization maintaining (PM) fiber inserted into a standard single mode fiber based laser cavity can function as a spectral selective filter. Adjustment of the length of the PM fiber from 1 to 2 m led to a corresponding variation in the pulse duration from 2 to 3.8 ps, the spectral bandwidth of the laser output changes from 0.15 to 1.26 nm.

Laser output wavelength detuning within up to 5 nm was demonstrated with a fixed length of the PM fiber by adjustment of the polarization controller.
The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017.

During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors.

This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.
The aim of this work was the analysis of structural changes with age in the hippocampus of senescenceaccelerated OXYS rats when signs of accelerated brain aging are missing (age 14 days), developments (age 5 months), and active progresses (age 15 months). The study was performed on 15 OXYS rats and 15 Wistar rats (as a control). After dislocation, brains were dissected, fixed with 10% formalin, embedded in paraffin, and serially cut in coronal sections (5μm thickness). These sections were stained with Cresyl violet and examined with a photomicroscope (Carl Zeiss Axiostar plus, Germany). The total number of hippocampal pyramidal cells in the CA1, CA3 and the dentate gyrus regions were estimated in 14-dayold, 5and 15-month-old OXYS and Wistar rats (n = 5) on the 5 slices of each brain sections. The number of neurons with chromatolysis, hyperchromatic with darkly stained cytoplasm and shrunken neurons were calculated as degenerative neurons. The pictures obtained with the program Carl Zeiss Axio Vision 8.0 with increasing 10  100, determined the average area bodies and nuclei of neurons (mkm2). The significant structural changes of neurons in the CA1, CA3 and dentate gyrus regions of the hippocampus in OXYS rats at 5 month of age are revealed by light microscopy. This results indicates the early develop neurodegeneration in OXYS rats. The most pronounced morphological changes occur in the CA1 region of the hippocampus of OXYS rats and irreversible. The degenerative changes of neurons in the hippocampus increases by the age of 15 months. Morphometric analysis of the average area of bodies and the nuclei of hippocampal neurons in CA1, CA3 and the dentate gyrus regions of OXYS and Wistar rats at 14 days of age showed no significant interline differences. At 5 months of age in the CA1 region of the hippocampus of OXYS rats was determined a significantly lower average body size and nuclei of pyramidal neurons compared with Wistar rats. With age, these changes have progressed and 15-month-old OXYS rats have a significant decrease in the area bodies and nuclei in all studied regions of the hippocampus compared with Wistar rats. These results confirm the promising use OXYS rats as a model of accelerated brain.
Cerebral arteriovenous malformation is a congenital pathology of development, in which the arterial and venous blood channels are connected by a nidus of randomly interwoven degenerate vessels. This is a dangerous disease that affects brain functioning and the risk of intracerebral hemorrhage is high. One of AVM treatment methods is embolization – the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative rupture of AVM vessels. In this paper, the optimal scenario of AVM embolization is studied from the point of view of safety and effectiveness of the procedure. The joint movement of blood and embolic agent in the AVM body is modeled on the basis of a one-dimensional two-phase filtration model. In numerical analysis, the modification of the CABARET scheme is used. On the basis of clinical data, models for three real patients are constructed. For a special law of embolic agent delivery, acceptable and optimal scenarios of embolization are calculated.
Glioblastoma is the most aggressive type of brain tumors resistant to a number of antitumor drugs. The problem of therapy and drug treatment course is complicated by extremely high heterogeneity in the benign cell populations, the random arrangement of tumor cells, and polymorphism of their nuclei. The pathogenesis of gliomas needs to be studied using modern cellular technologies, genome- and transcriptome-wide technologies of high-throughput sequencing, analysis of gene expression on microarrays, and methods of modern bioinformatics to find new therapy targets. Functional annotation of genes related to the disease could be retrieved based on genetic databases and cross-validated by integrating complementary experimental data. Gene network reconstruction for a set of genes (proteins) proved to be effective approach to study mechanisms underlying disease progression. We used online bioinformatics tools for annotation of gene list for glioma, reconstruction of gene network and comparative analysis of gene ontology categories. The available tools and the databases for glioblastoma gene analysis are discussed together with the recent progress in this field.
Results of the studies into the features of the geochemistry of radon waters from the Zaeltovsky-Mochishche zone of Novosibirsk city are reported. Radon waters are fracture, cold with the temperature of 6-10 оC, they occur at a depth of 50-200 m. In the hydrogeological section, neutral and weakly alkaline waters are developed, with рН from 6,9 to 7,8, mainly with the calcium hydrocarbonate and calcium-sodium hydrocarbonate composition, with total mineralization from 322 to 895 mg/dm3. The concentrations of 222Rn in water-saturated zones of granites vary from 308 to 1521 Bq/dm3, while in the wells drilled into hornstones radon content varies within the range 37-241 Bq/dm3. The concentrations of 238U and 226Ra do not exceed 0.098 mg/dm3 and 3.5∙10-7 mg/dm3, respectively.
We investigate electron transport through the interface between a niobium superconductor and the edge of a two-dimensional semimetal, realized in a 20~nm wide HgTe quantum well. Experimentally, we observe that typical behavior of a single Andreev contact is complicated by both a pronounced zero-bias resistance anomaly and shallow subgap resistance oscillations with $1/n$ periodicity. These results are demonstrated to be independent of the superconducting material and should be regarded as specific to a 2D semimetal in a proximity with a superconductor. We interpret these effects to originate from the Andreev-like correlated process at the edge of a two-dimensional semimetal.
Here, we report the production of 13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles

followed by magnetic field cycling
The implementation of the machine learning methods of convolutional neural networks to enhance RANS closure models is presented. The RANS models are not universal and accurate, however they are computationally affordable. Finding a way to improve the model predictability will be an advantage. For this, machine learning algorithms based on available high-fidelity data sets for canonical flow cases obtained from DNS and measurements can be helpful. The application of these algorithms for a fully-developed turbulent channel flows with periodic hills, in a square duct and for other cases is considered.
The new manufacturing method for fabrication of Surface Nanoscale Axial Photonics (SNAP) structures has been developed.

We showed experimentally that the bent fiber can achieve the nanometer-scale variation in the effective fiber radius sufficient for fabrication of SNAP microresonators.

The advantage of the demonstrated method is in its simplicity, robustness, and mechanical tunability of the fabricated devices.
Only three glycine co-crystals with carboxylic acids were reported till now: those with glutaric[1a], DL-tartaric[1b] and phthalic acids[1c]. Co-crystallisation of glycine with some other carboxylic acids (oxalic, malonic, maleic) gives molecular salts. The reason why the three selected carboxylic acids form not salts, but co-crystals with glycine remains unclear. No obvious correlations with any physiochemical properties of acidic co-formers such as solubility, acidity, dissolution rate, geometry of molecule, etc. could be suggested.

The effect of pressure and temperature on a co-crystal of glycine with glutaric acid was investigated in our research group under low temperatures[2] and high pressure[3] and a first order phase transition giving the same new polymorph was observed (at 220 K and 1.75 GPa, respectively). No variable-temperature or variable-pressure studies of co-crystals of glycine with DL-tartaric and phthalic acids were reported. The aim of the present study was to compare the behavior of three glycinium co-crystals at low temperature and high pressure. The changes in the unit cell volumes and parameters, as well as in the geometry of the hydrogen bonds were analysed. The orientation of principal axes of strain ellipsoid with respect to the main structural motifs and relative linear strain values along these axes were calculated. The conformations and the local environment of glycine molecules, as well as the hydrogen-bonded motifs were compared for three co-crystals.

The work was supported by the Russian Foundation for Basic Research (RFBR) (Grants No. 14-03-31866 mol_a, 13-03-92704 IND_a), Russian Ministry of Science and Education and Russian Academy of Sciences.