Hengzongshu/ArticleAgent huggingface dataset:
The article discusses the oil and gas complex of the Siberian Federal District at the stage of the need to transition to a new paradigm of development of the oil and gas complex of Russia. Over the past decade, the Siberian Federal District has been the most dynamic region of Russia in the development of the last large and unique oil fields, the development of the mining and transport infrastructure. Increasing oil production and exports in the region at the expense of unique and large fields will continue until 2020s, after which the decline in liquid hydrocarbon production should be offset by developing hard-to-recover and unconventional sources of hydrocarbons, as well as medium and small fields, and rational development of residual reserves. in new and traditional mining centers of the Siberian region. All this will require a radical restructuring of the organizational and legislative system of subsoil use, the transition from an extensive to an intensive development model, the creation of new technologies and equipment, and the provision of integrated development of the subsoil.
A measurement of the ratio of the branching fractions of the $B^{+}\rightarrow K^{+}\mu^{+}\mu^{-}$ and $B^{+}\rightarrow K^{+}e^{+}e^{-}$ decays is presented using proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb$^{-1}$, recorded with the LHCb experiment at center-of-mass energies of 7 and 8 $\mathrm{\,Te\kern -0.1em V}$. The value of the ratio of branching fractions for the dilepton invariant mass squared range $1
Bioinformatic resources (databases of the gene nets, transcriptional and posttranscriptional expression signals, programs for recognition of functional sites and prediction of their activities) are reviewed in respect of their utility for gene engineering experiments.img src="http://elibrary.ru/pic/1pix.gif" /
This study falls within the framework of industrial exploitation of the essential oil recovered from Pituranthos scoparius. Chromatographic techniques, namely TLC, HPTLC, MHE-GC-FID-MS, GC X GC, and GC-FID-MS have been used for the characterization, identification and quantification of 48 compounds, divided into three major terpene groups: monoterpenes, diterpenes, and oxygenated compounds. The essential oil displayed an antioxidant activity, presented by a radical scavenging activity and evaluated by the TLC–DPPH• method. Tests conducted at laboratory scale showed high protection from lipid oxidation of the spread emulsion, with an oxidative stability of 20.82 h. A sensory evaluation was carried out on emulsions incorporated with the essential oil. The PCA analysis revealed the effect of some attributes on the segregation between the four emulsions formulated. These data suggest that the essential oil of Pituranthos scoparius is a possible and promising candidate as a biopreservative at an industrial scale for food preservation. Practical applications Essential oil of Pituranthos scoparius is traditionally used in folk medicine as a remedy for several illnesses. Its antibacterial properties are also exploited in the preservation of traditional cheese making. Whey is a by-product of cheese and casein industries, still considered as a waste. Valorization of this by-product in a whey spread emulsion is considered in the present work. Due to the bioactive compounds contained in the essential oil (such as terpinen-4-ol), the essential oil exhibits high antioxidant activity. As oxidation phenomena becomes a topical issue in fat and oil food industry, natural plants containing essential oils with high antioxidant properties are considered as good alternatives to synthetic antioxidants.
We present high-resolution, all-optical thermometry based on ensembles of germanium-vacancy (GeV) color center in diamond and implement this method of thermometry in the fiber-optic format. Due to the unique properties of diamond, an all-optical approach using this method opens a way to produce back-action-free temperature measurements with resolution below 0.1 K in a wide range of temperatures.
A baryonic decay of the ${B}_{c}^{+}$ meson, ${B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}p\overline{p}{\ensuremath{\pi}}^{+}$, is observed for the first time, with a significance of 7.3 standard deviations, in $pp$ collision data collected with the LHCb detector and corresponding to an integrated luminosity of $3.0\text{ }\text{ }{\text{fb}}^{\ensuremath{-}1}$ taken at center-of-mass energies of 7 and 8 TeV. With the ${B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}$ decay as the normalization channel, the ratio of branching fractions is measured to be $\mathcal{B}({B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}p\overline{p}{\ensuremath{\pi}}^{+})/\mathcal{B}({B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+})=0.14{3}_{\ensuremath{-}0.034}^{+0.039}(\text{stat})\ifmmode\pm\else\textpm\fi{}0.013(\text{syst})$. The mass of the ${B}_{c}^{+}$ meson is determined as $M({B}_{c}^{+})=6274.0\ifmmode\pm\else\textpm\fi{}1.8(\text{stat})\ifmmode\pm\else\textpm\fi{}0.4(\text{syst})\text{ }\text{ }\mathrm{MeV}/{c}^{2}$, using the ${B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}p\overline{p}{\ensuremath{\pi}}^{+}$ channel.
In the present work simultaneous velocity field and passive admixture concentration field measurements at realistic flow-rates conditions in a non-reacting flow in a model of combustion chamber with an industrial mixing device are reported. In the experiments for safety reasons the real fuel (natural gas) was replaced with neon gas to simulate stratification in a strongly swirling flow.

Measurements were performed by means of planar laser-induced fluorescence (PLIF) and particle image velocimetry technique (PIV) at Reynolds number, based on the mean flow rate and nozzle diameter, ≈300 000. Details on experimental technique, features of the experimental setup, images and data preprocessing procedures and results of performed measurements are given in the paper.

In addition to the raw velocity and admixture concentration data in-depth evaluation approaches aimed for estimation of turbulent kinetic energy (TKE) components, assessment of turbulent Schmidt number and analysis of the gradient closure hypothesis from experimental data are presented in the paper.
Krebs-2 solid carcinoma was cured using a new '3+1' strategy for eradication of Krebs-2 tumor-initiating stem cells.

This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the 'winter repair cycle' (November-April), is completely eliminated in the summer period (June-September).

We conclude that оne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy.
Back pain (BP) is a common condition of major social importance and poorly understood pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts allowed us to perform a very large genome-wide association study (total N = 509,070) and examine the genetic correlation and pleiotropy between BP and its clinical and psychosocial risk factors. We identified and replicated 3 BP-associated loci, including one novel region implicating SPOCK2 / CHST3 genes. We provide evidence for pleiotropic effects of genetic factors underlying BP, height, and intervertebral disk problems. We also identified independent genetic correlations between BP and depression symptoms, neuroticism, sleep disturbance, overweight, and smoking. A significant enrichment for genes involved in the central nervous system and skeletal tissue development was observed. The study of pleiotropy and genetic correlations, supported by the pathway analysis, suggests at least 2 strong molecular axes of BP genesis, one related to structural/anatomical factors such as intervertebral disk problems and anthropometrics, and another related to the psychological component of pain perception and pain processing. These findings corroborate with the current biopsychosocial model as a paradigm for BP. Overall, the results demonstrate BP to have an extremely complex genetic architecture that overlaps with the genetic predisposition to its biopsychosocial risk factors. The work sheds light on pathways of relevance in the prevention and management of low BP.
The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.

We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that recruited 2479 participants aged 35–69 years from the general population of the city of Arkhangelsk in Northwest Russia and 278 patients from the Arkhangelsk Regional Psychiatric Hospital with a primary diagnosis related to chronic alcohol use (narcology clinic subsample). The drinking patterns of the population-based sample were characterised in detail. We used regression models controlling for age, sex, smoking, education and waist to hip ratio to evaluate the differences in echocardiographic indices in participants with different drinking patterns. The means of left ventricular end-diastolic diameter and indexed left atrial systolic diameter were increased among heavy drinkers (narcology clinic subsample), while mean left ventricular ejection fraction was decreased in this group compared with the population-based sample. In contrast, the harmful and hazardous drinkers in the population-based sample did not differ from non-problem drinkers with respect to echocardiographic indices of systolic and diastolic function.

Extremely heavy drinking is associated with a specific set of structural and functional abnormalities of the heart that may be regarded as precursors of alcohol-related dilated cardiomyopathy.
The spectral study results of a supersonic clustered argon flow stimulated emission in the region of particle excitation (on an electron beam) and downstream are presented. Anomalies in the luminescence of the traditional spindle-shaped jet and the flow of heavy clusters (“wake”) are discussed. Possible causes of the observed anomalous phenomena are presented on the basis of the given comparisons of the results obtained.
Here we investigate the plant population genetics of retrotransposon insertion sites in pea to find out whether genetic drift and the neutral theory of molecular evolution can account for their abundance in the pea genome.

We used the recently assembled v1a pea genome sequence to obtain data on LTR-LTR divergence from which their age can be estimated. We coupled these data to prior information on the distribution of insertion site alleles.

We found that the age and frequency distribution data are consistent with the neutral theory. We concluded that demographic processes are the underlying cause of genome size variation in legumes.
The paper is devoted to the experimental study of convection in a horizontal evaporating liquid layer (ethanol) of limited size under the action of gas flow (air). The two-dimensional velocity field in the liquid layer is obtained using the PIV method. The existence of a vortex convective flow within a liquid layer directed towards the gas flow has been revealed.
The phenomenon of bacterial persistence – a non-inherited antibiotic tolerance in a minute fraction of the bacterial population, was observed more than 70 years ago. Nowadays, it is suggested that “persister cells” undergo an alternative scenario of the cell cycle; however, pathways involved in its emergence are still not identified.

We present a mathematically grounded scenario of such possibility. We have determined that population drift in the space of multiple neutrally coupled mutations, which we called “neutrally coupled co-evolution” (NCCE), leads to increased dynamic complexity of bacterial populations via appearance of cells capable of carrying out a single cell cycle in two or more alternative ways and that universal properties of the coupled transcription-translation system underlie this phenotypic multiplicity.

According to our hypothesis, modern persister cells have derived from such cells and regulatory mechanisms that govern the consolidation of this phenomenon represented the trigger. We assume that the described type of neutrally coupled co-evolution could play an important role in the origin of extremophiles, both in bacteria and archaea.
According to the results of a study that involved 32 psoriatic patients, nevi with the diameter exceeding 5 mm are found in 68.8% of patients including 36% of patients with iatrogenic melanoma development risk factors (treatment with methotrexate and phototherapy), 50% of patients with anamnestic (burn injuries including vesication at the age below 18) and 4.5% of patients with inherited risk factors (melanoma in their relatives). As many as 32.4% of the nevi met the dysplastic nevi criteria in the course of the Pehamberger model analysis.
Study of convection in a horizontal liquid layer (ethanol) evaporating into the gas flow (air) has been performed.The two-dimensional velocity field in the liquid layer is obtained using the PIVmethod. It is shown that the temperature rise induces significant changes in the convective flow structure. The main factor determining structure of convective flows within the liquid is the thermocapillary effect.
Experimental data on the linear and nonlinear wave train development in 3D supersonic boundary layer over a 45° swept-wing at Mach number 2.5 are presented.

Travelling artificial disturbances were introduced in the boundary layer by periodical glow discharge at frequencies 10 and 20 kHz. The spatial-temporal and spectral-wave characteristics of the wave train of unstable disturbances in the linear region are obtained.

It is shown that the additional peaks in β'-spectra arise for both subharmonic and fundamental frequencies. The experiments indicate the presence of subharmonic resonance mechanism in 3D boundary layer at Mach number 2.5.
The antimicrobial bioactivity of silver nanoparticles is well known, and they can be used widely in many applications, becoming especially important in the biomedical industry. On the other hand, the electrospun nanofibers possess properties that can enhance silver nanoparticle applicability.

This review is aimed at comparing different silver incorporation methods into electrospun nanofibers and their antimicrobial activity, discussing each procedure's limitations, and presenting the most promising one.

This review showed that the preferred techniques for incorporating silver nanoparticles were direct blending and ultraviolet irradiation methods due to their simplicity and efficient results. Besides, polyacrylonitrile nanofibers (PAN) have been the most reported system loaded with silver nanoparticles. Finally, independently of the technique used, silver nanoparticle-loaded nanofibers show high antimicrobial activity in all cases.
In our previous paper [Terekhov et al., Phys. Rev. E 95, 062133 (2017)2470-004510.1103/PhysRevE.95.062133] we considered the optical channel modeled by the nonlinear Schrödinger equation with zero dispersion and additive Gaussian noise. We found per-sample channel capacity for this model.

In the present paper we extend the per-sample channel model by introducing the initial signal dependence on time and the output signal detection procedure. The proposed model is a closer approximation of the realistic communications link than the per-sample model where there is no dependence of the initial signal on time. For the proposed model we found the correlators of the output signal both analytically and numerically. Using these correlators we built the conditional probability density function. Then we calculated an entropy of the output signal, a conditional entropy, and the mutual information.

Maximizing the mutual information we found the optimal input signal distribution, channel capacity, and their dependence on the shape of the initial signal in the time domain for the intermediate power range.
We address the problem of relative frequencies of singlet and triplet recombinations in a multiparticle system, which consists of spin-correlated radical ion pairs. The nonlocal swapping of spin correlations due to cross-recombinations is taken into account. It is shown that this swapping does not contribute to singlet and triplet recombination frequencies in the absence of spin evolution in the correlated pairs.
Hydrolytic deamination of cytosine to uracil generates a highly mutagenic DNA base lesion and is considered one of the major sources of spontaneous mutation in living organisms.

We report that the major human apurinic/apyrimidinic (AP) endonuclease, APE1, is a deoxyuridine endonuclease and can remove uracil residues in the DNA glycosylase-independent nucleotide incision repair pathway.

This new repair function of AP endonucleases is evolutionarily conserved in Archaea and humans, pointing to a possible evolutionary origin of the DNA repair mechanisms for spontaneous damage to DNA in a common ancestor to all living forms.
Recently, many major cities in the world have faced a serious environmental problem caused by the presence of a large amount of waste and the established practice of their treatment. The paper presents an assessment of the energy potential of wastewater sludge (WWS) in the context of Novosibirsk city. According to our estimates, the total amount of generated semi-liquid WWS is about 132,000 tons per year, the theoretical energy output amounts to 67 GW per year, which is more than three times the total heat produced by small boiler plants in the region. Chemical compositions of WWS and stone/brown coals differ slightly. WWS contains 24.5% less carbon than coal and 5% less carbon than brown coal. The proportion of sulfur in WWS exceeds its specific content in coal by only 0.2% and in brown coal – by 4%. Seven alternative wastewater sludge utilization options have been developed, based both on new non-traditional waste incineration technologies and on finished turnkey technologies. WWS utilization options are evaluated in terms of economic efficiency, energy value, and environmental impact. The efficient option is the one associated with the utilization of WWS based on combustion with coal in a thermal power plant.
A model of synthetic gas hydrates in a mixture of quartz pellets is considered using by tetrahydrofuran solution based on distilled water.

The analysis of the NMR-characteristics of tetrahydrofuran hydrate in clayed sand is performed.

The stages of hydrate dissociation excluding water contribution are established and it is shown that the NMR-relaxometry method is sensitive to the clay content. The obtained results allow us to more detailed study the processes of hydrate formation in real reservoir rocks and their physical characteristics.
A terrible disease of the cardiovascular system, atherosclerosis, develops in the areas of bends and branches of arteries, where the direction and modulus of the blood flow velocity vector change, and consequently so does the mechanical effect on endothelial cells in contact with the blood flow. The review focuses on topical research studies on the development of atherosclerosis – mechanobiochemical events that transform the proatherogenic mechanical stimulus of blood flow – low and low/oscillatory arterial wall shear stress in the chains of biochemical reactions in endothelial cells, leading to the expression of specific proteins that cause the progression of the pathological process. The stages of atherogenesis, systemic risk factors for atherogenesis and its important hemodynamic factor, low and low/oscillatory wall shear stress exerted by blood flow on the endothelial cells lining the arterial walls, have been described. The interactions of cell adhesion molecules responsible for the development of atherosclerosis under low and low/oscillating shear stress conditions have been demonstrated. The activation of the regulator of the expression of cell adhesion molecules, the transcription factor NF­κB, and the factors regulating its activation under these conditions have been described. Mechanosensitive signaling pathways leading to the expression of NF­κB in endothelial cells have been described. Studies of the mechanobiochemical signaling pathways and interactions involved in the progression of atherosclerosis provide valuable information for the development of approaches that delay or block the development of this disease.
Characteristics of the film flow were determined experimentally using simultaneous measurements of the thickness and temperature fields on the surface of the falling heated liquid film (LIF and IR scanner).

Three different types of instability were registered on the surface of the heated liquid film: 3D hydrodynamic and two thermocapillary A and B instabilities. The development of thermocapillary structures of type A was considered in the residual layer behind the wave front.

These structures caused a disturbance in the following wave front, leading to an increase in the amplitude of the waves. It was found that the amplitude of hydrodynamic waves in the upper part of the heater could be increased. The development of thermocapillary structures of type A at high heat flux initiated increasing of the rivulets deflection amplitudes.