Hengzongshu/ArticleAgent huggingface dataset:
The development of effective system of path searching in space is becoming an important task for organizations that render consumer services, and the use of neuromarketing, eye tracking in particular, makes it possible to solve it. The article reviews the approaches of scientists regarding navigation systems research; the research results using the method of trajectory tracking and eye movement for improvement of the search of necessary objects by service consumers in healthcare institution are outlined. The method testing proved to be successful. The use of eye tracking in the marketing research boosted the quality and made it possible to perform necessary improvement with clear proof of its effect, as well as demonstrate the significance of eye tracking use for improvement of the spatial consumer orientation.
A cytogenetic investigation was performed in eight species of the spittlebug genus Philaenus using silver-NOR (AgNOR)-banding and fluorescence in situ hybridization (FISH) with 18S rDNA and (TTAGG)n telomeric probes.This is the first application of FISH technique in the Auchenorrhyncha, a suborder of the Hemiptera.FISH along with the rDNA probe revealed differences between species in the number and chromosomal location of major ribosomal RNA gene sites, the so-called nucleolar organizer regions (NORs).However, we found a lack of perfect correlation between the results of AgNOR-staining and rDNA-FISH in the detection of NORs.FISH with the telomeric probe confirmed that the chromosome ends of the Philaenus species are composed of the (TTAGG)n nucleotide sequence, which is a common motif of insect telomeres.
Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control. Here, we identify the NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway for the G1/S transition. In response to mitogenic stimulation, NUCKS1, a transcription factor, is recruited to chromatin to activate expression of SKP2 , the F-box component of the SCF SKP2 ubiquitin ligase, leading to degradation of p21 and p27 and promoting progression into S phase. In contrast, DNA damage induces p53-dependent transcriptional repression of NUCKS1 , leading to SKP2 downregulation, p21/p27 upregulation, and cell cycle arrest. We propose that the NUCKS1-SKP2-p21/p27 axis integrates mitogenic and DNA damage signalling to control S phase entry. TCGA data reveal that this mechanism is hijacked in many cancers, potentially allowing cancer cells to sustain uncontrolled proliferation.
The global goal of the world community is the transition to a “green” economy, characterized by rational use of electricity, reduction of harmful emissions, and consumption of renewable energy sources. The purpose of the research was to study the convergence of capacity emissions in developing countries to European countries’ level. According to the results, countries striving for a lower emission intensity level to varying degrees. In non-OECD European countries, per capita income growth leads to a 0.26% reduction in emissions intensity. This fact means that economic growth creates additional resources that can be used to develop energy-efficient technologies. In the post-Soviet space and the Asia-Pacific region, a significant effect on reducing emission intensity is provided by environmental policy’s effectiveness to minimize carbon dioxide emissions.
As the most abundant protein with a variety of physiological functions, human serum albumin (HSA) has been used extensively for the delivery and improvement of therapeutic molecules. Thiolactone chemistry provides a powerful tool to prepare albumin-based multimodal imaging probes and agents for boron neutron capture therapy (BNCT). For this purpose, boron containing 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye was designed and synthesized. BODIPY dyes are photostable neutral derivatives of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene. These are widely used as chemosensors, laser materials and molecular probes. At the same time, BODIPY dyes, like most other fluorophores, have small or moderate Stokes shifts. Large Stokes shifts are preferred for fluorophores because of higher sensitivity of such probes and sensors.

We succeeded in performing an annulation of pyrrole ring with coumarin heterocyclic system and achieved a remarkable difference in absorption and emission maximum of obtained fluorophore up to 100 nm. Moreover, this BODIPY dye was equipped with a linker arm and was functionalized with a maleimide residue specifically reactive towards thiol groups of proteins. The released sulfhydryl groups of the homocysteine functional handle in thiolactone modified HSA was labeled with BODIPY dye to prepare a labeled albumin-BODIPY dye conjugate confirmed by MALDI-TOF-MS, UV-vis and fluorescent emission spectra. The cytotoxicity of HSA conjugate was evaluated by MTT assay in cell lines MCF-7 and T98G.

This is the basis for a novel BODIPY dye -albumin theranostic for BNCT. These results provide further impetus to develop derivatives of HSA for delivery of boron to cancer cells.
In the paper, we obtain some representations for solutions and coecients of Blokhintsev equation under condition the solutions satisfy to supplementary quasi-linear equation.These results may be used in the problems of identication of solutions and coecients given supplementary initial-boundary information.
Molybdenum disulfide (MoS2) was grown on a laser-processed periodic-hole sapphire substrate through chemical vapor deposition. The main purpose was to investigate the mechanism of MoS2 growth in substrate with a periodic structure.

By controlling the amount and position of the precursor, adjusting the growth temperature and time, and setting the flow rate of argon gas, MoS2 grew in the region of the periodic holes. A series of various growth layer analyses of MoS2 were then confirmed by Raman spectroscopy, photoluminescence spectroscopy, and atomic force microscopy. Finally, the growth mechanism was studied by transmission electron microscopy (TEM).

The experimental results show that in the appropriate environment, MoS2 can be successfully grown on substrate with periodic holes, and the number of growth layers can be determined through measurements. By observing the growth mechanism, composition analysis, and selected area electron diffraction diagram by TEM, we comprehensively understand the growth phenomenon. The results of this research can serve as a reference for the large-scale periodic growth of MoS2. The production of periodic structures by laser drilling is advantageous, as it is relatively simpler than other methods.
The analysis is based on a 711 fb−1 data sample that contains 772×106 BB¯ pairs collected at the Υ(4S) resonance by the Belle detector at the asymmetric-energy e+e− collider KEKB.

We perform a full amplitude analysis of B0→ψ′K+π− decays, with ψ′→μ+μ− or e+e−, to constrain the spin and parity of the Z(4430)−.

The JP=1+ hypothesis is favored over the 0−, 1−, 2− and 2+ hypotheses at the levels of 3.4σ, 3.7σ, 4.7σ and 5.1σ, respectively.
In direct numerical simulations of a turbulent jet, propagating helical waves which contain much of the energy are tracked from the near to the far field in order to find their scaling properties and dispersion laws.
A new algorithm is proposed for the determination of aerosol particle size distribution from a set of screen diffusion battery penetrations.

The idea is to determine the size spectra of the fractions of particles separated by the sections of diffusion battery, so the total size distribution is the sum of the spectra of fractions. The spectrum of each fraction is approximated by the lognormal function, which is defined by two parameters: the standard geometric deviation (SGD) and geometric mean diameter. The SGD value is chosen to be 1.35 for each fraction. The geometric mean diameters of fractions are calculated from the diffusion battery penetrations. For this purpose, analytical formulas are derived to link the mean single-fiber collection efficiency for each fraction with the experimentally measured penetrations. Then the mean diameters of fractions are calculated from the collection efficiencies using the fan model filtration theory. To achieve a better size resolution, numerical approach is proposed to calculate the particle size spectrum using the analytical solution as an initial approximation. The validity of the analytical and numerical solutions is investigated by comparing them with the spectra determined by means of transmission electron microscopy and gravity settling. For this purpose, the aerosol is generated using the evaporation-nucleation technique, Collison-type nebulizer, and hot-wire bulb generator.

It is found that the analytical solution demonstrates a good sizing accuracy but relatively poor size resolution, while the numerical approach results in both good sizing accuracy and good size resolution for the two-mode aerosol.
We present the results of an amplitude analysis of anti-B0 -> J/psi K- pi+ decays.

The analysis is based on a 711 fb^-1 data sample collected by the Belle detector at the asymmetric-energy e+ e- collider KEKB.

A new charged charmoniumlike state Zc(4200)+ decaying to J/psi pi+ is observed with a significance of 6.2 sigma. The mass and width of the Zc(4200)+ are 4196 +31-29 +17-13 MeV/c^2 and 370 +70-70 +70-132 MeV, respectively; the preferred assignment of the quantum numbers is J^P = 1^+. In addition, we find evidence for Zc(4430)+ -> J/psi pi+.
Individuals exposed to social stress in childhood are more predisposed to developing psychoemotional disorders in adulthood. Here we use an animal model to determine the influence of hostile social environment in adolescence on behavior during adult life. One-month-old adolescent male mice were placed for 2 weeks in a common cage with an adult aggressive male. Animals were separated by a transparent perforated partition, but the adolescent male was exposed daily to short attacks from the adult male. After exposure to social stress, some of the adolescent mice were placed for 3 weeks in comfortable conditions. Following this rest period, stressed young males and adult males were studied in a range of behavioral tests to evaluate the levels of anxiety, depressiveness, and communicativeness with an unfamiliar partner. In addition, adult mice exposed to social stress in adolescence were engaged in agonistic interactions. We found that 2 weeks of social stress result in a decrease of communicativeness in the home cage and diminished social interactions on the novel territory. Stressed adolescents demonstrated a high level of anxiety in the elevated plus-maze test and helplessness in the Porsolt test. Furthermore, the number of dividing (BrdU-positive) cells in the subgranular zone of the dentate gyrus was significantly lower in stressed adolescents. After 3 weeks of rest, most behavioral characteristics in different tests, as well as the number of BrdU-positive cells in the hippocampus, did not differ from those of the respective control mice. However, the level of anxiety remained high in adult males exposed to chronic social stress in childhood. Furthermore, these males were more aggressive in the agonistic interactions. Thus, hostile social environment in adolescence disturbs psychoemotional state and social behaviors of animals in adult life.
This paper presents a study of the properties of surfaces with nanocoatingsof two types:NOA 81 photoresist with silanizationand NOA 65 photoresist. These surfaces are resistant to thermal and mechanical loads. The structure of the surfaces was investigated by scanning electron microscopy. The contact angle hysteresis for these surfaces wasdeterminedby the standard DSA-100 KRUSSprocedure, in which theadvancing and receding contact angles are measured, and also by a second method - measuring the contact angle under isothermal droplet evaporation. The contact angle hysteresis values measured by the two different methods are in satisfactory agreement. The contact angle hysteresis was about 20° for the NOA 81 substrateand about 50° for NOA 65.
The central Vanuatu forearc is characterized by a reduced convergence rate at the trench, significant uplift of the overriding plate, and the presence of large forearc islands. Volcanic activity and intermediate‐depth seismicity behind the forearc are among the highest on Earth. These features are presumed to be associated with the subduction of a large seamount chain and an immersed ridge. We used a catalog of P and S arrivals from a local seismological network to construct the first 3‐D velocity model of the region and to relocate earthquakes beneath the forearc. The 3‐D model reveals a highly heterogeneous velocity distribution in the first 40 km beneath the surface. Trench‐parallel low P and S velocity zones in the upper tens of kilometers beneath the western edges of the two largest forearc islands correlate to the major features entering into subduction and suggest highly fractured and probably water‐infiltrated features. Trench‐parallel high‐velocity zones at 5–15‐km depth, further to the east, may be part of a continuous consolidated rock structure that acts as a backstop. Thick overriding plate crust (29 ± 3 km) in the forearc is consistent with the presence of continental remnants. The earthquake distribution is generally heterogeneous, suggesting a complex fault structure and variable stress. Earthquakes are, however, well aligned at the plate interface in between the subducting features, where they constrain the angle of subduction to be 15° on average, down to 10–15‐km depth.
Emplacement of large volumes of (sub)volcanic rocks during the main pulse of the Siberian Traps occurred within <1 m.y., coinciding with the end-Permian mass extinction. Volcanics from outside the main Siberian Traps, e.g. Taimyr and West Siberia, have since long been correlated, but existing geochronological data cannot resolve at a precision better than ~5 m.y. whether (sub)volcanic activity in these areas actually occurred during the main pulse or later.

We report the first high precision U-Pb zircon geochronology from two alkaline ultramafic-felsic layered intrusive complexes from Taimyr, showing synchronicity between these and the main Siberian Traps (sub)volcanic pulse, and the presence of a second Dinerian-Smithian pulse. This is the first documentation of felsic intrusive magmatism occurring during the main pulse, testifying to the Siberian Trap’s compositional diversity. Furthermore, the intrusions cut basal basalts of the Taimyr lava stratigraphy hence providing a minimum age of these basalts of 251.64 ± 0.11 Ma.

Synchronicity of (sub)volcanic activity between Taimyr and the Siberian Traps imply that the total area of the Siberian Traps main pulse should include a ~300 000 km 2 area north of Norilsk. The vast aerial extent of the (sub)volcanic activity during the Siberian Traps main pulse may explain the severe environmental consequences.
The enhancement of Raman scattering by optical phonon modes in quantum dots was achieved in resonant and surface-enhanced Raman scattering experiments by approaching the laser energy to the energy of either the interband transitions or the localized surface plasmons in silver nanoclusters deposited onto the nanostructures.

Resonant Raman scattering by TO, LO, and SO phonons as well as their overtones was observed for PbS, ZnS, and ZnO quantum dots while enhancement for LO and SO modes in CdS quantum dots with a factor of about 700 was measured in surface enhanced Raman scattering experiments.

Multiple phonon Raman scattering observed up to 5th and 7th order for CdS and ZnO, respectively, confirms the high crystalline quality of the grown QDs.
Results of the study of the stable isotopes (δ 18 O, δD and δ 13 C) distribution in natural waters of the Baydar valley (southwestern part of the Crimean Peninsula) are presented. The study region holds fresh and ultra-fresh waters of predominantly bicarbonate calcium composition with TDS varying from 194 to 1137 mg/dm 3 . The research results revealed that all of the studied waters are of atmospheric origin that lie either along the global (GMWL) or local (LMWL) meteoric water lines. The established variations are: from -9.5 to -5.6‰ for δ 18 O values in waters with δD values varying from -64.0 to -40.0‰. The source for bicarbonate ion enriched in δ 13 C in natural waters of the Bauydar valley are carbonate sedimentary rocks, atmospheric carbon dioxide and organic compounds. Surface waters have heavier isotopic composition δ 13 C (-9.2 – -7.0‰) because of the atmospheric CO 2 . Artesian waters are differentiated by lighter δ 13 C (-12.8 – -10.7‰) due to the interactions between carbonate rocks and the dispersed organic matter. Water sources (springs, wells) are characterized by the widest variations of δ 13 C (-6.9 – -15.5‰) due to the presence of the atmospheric CO 2 and intense processes of biochemical decomposition of organic compounds in the soil layer.
Vernalization genes VRN1 play a major role in the transition from vegetative to reproductive growth in wheat. In di-, tetra- and hexaploid wheats the presence of a dominant allele of at least one VRN1 gene homologue (Vrn-A1, Vrn-B1, Vrn-G1 or Vrn-D1) determines the spring growth habit. Allelic variation between the Vrn-1 and vrn-1 alleles relies on mutations in the promoter region or the first intron. The origin and variability of the dominant VRN1 alleles, determining the spring growth habit in tetraploid wheat species have been poorly studied.Here we analyzed the growth habit of 228 tetraploid wheat species accessions and 25 % of them were spring type. We analyzed the promoter and first intron regions of VRN1 genes in 57 spring accessions of tetraploid wheats. The spring growth habit of most studied spring accessions was determined by previously identified dominant alleles of VRN1 genes. Genetic experiments proof the dominant inheritance of Vrn-A1d allele which was widely distributed across the accessions of Triticum dicoccoides. Two novel alleles were discovered and designated as Vrn-A1b.7 and Vrn-B1dic. Vrn-A1b.7 had deletions of 20 bp located 137 bp upstream of the start codon and mutations within the VRN-box when compared to the recessive allele of vrn-A1. So far the Vrn-A1d allele was identified only in spring accessions of the T. dicoccoides and T. turgidum species. Vrn-B1dic was identified in T. dicoccoides IG46225 and had 11 % sequence dissimilarity in comparison to the promoter of vrn-B1. The presence of Vrn-A1b.7 and Vrn-B1dic alleles is a predicted cause of the spring growth habit of studied accessions of tetraploid species. Three spring accessions T. aethiopicum K-19059, T. turanicum K-31693 and T. turgidum cv. Blancal possess recessive alleles of both VRN-A1 and VRN-B1 genes. Further investigations are required to determine the source of spring growth habit of these accessions.New allelic variants of the VRN-A1 and VRN-B1 genes were identified in spring accessions of tetraploid wheats. The origin and evolution of VRN-A1 alleles in di- and tetraploid wheat species was discussed.
Purpose. The article examines communication failure which is one of the major factor of Chekhov’s poetics. The problem of architectonics is based on dialogue principle in narrative and values unity. Results. A Nightmare is a story of social misunderstanding. A public character Kunin treats a country priest father Yakov as a hard-drinking person. He is highly snobbish and refuses to hear the poor priest. Finally, his revelation of someone’s else being, except his own, shakes him much. But his newly gained knowledge about social issues such as destitution is not deep. Later, Kunin calms down and ruminates over his lack of money to help father Yakov and the other poor person, the doctor. The author’s conclusion discredits his attempt to become a better person. Overall, the dialogue of positions is just quasi-communication. In his next work, Enemies, Chekhov’s poetic construction appears to be more complicated. Doctor Kirilov and Abogin, a rich man, both experience grief, but the reasons for their grief are entirely different. Doctor has lost his only little son an hour before, but Abogin compels him to save his wife. When they arrive to Abogin’s country-estate, it turns out that the woman has just run away with her lover. This farce provokes the doctor’s rage. He blames Abogin, saying that the rich man’s distress is empty and ridiculous. According to the author, the offended Kirilov can hardly be considered wrong. And once again, the author’s conclusion sums up the short story. An existential connotation manifests the communication breakdown. The third short story, An Awkward Business, is devoted to problem of total communication failure. The main character, doctor Ovchinnikov, is not heard at all. His business matter turns out to be a matter of further existence, but nobody wants to understand the essence of his trouble. Finally, his case is interpreted in a formal way and is not solved. The author simply lets things go on, standing outside the text. And this is the innovative feature of Chekov’s mature creative work. Conclusion. To sum up, in three Chekhov’s short stories communication failure is an important factor of poetics, which is developed in his later works.
Each year about 400 000 people in Russia get strokes. Whereas an acute treatment takes place in specialized intensive care units in hospitals, follow-up is handed over to general (rarely – private) practitioner. The majority of stroke survivors show low adherence to follow-up resulting in repeated hospitalizations and growth of multi-morbidity burden. With COVID-19 pandemic negatively affecting availability of medical services and increasing health risks for stroke survivors, a physician-patient relation becomes the means of persuading patients to healthpromoting behaviour.
Hypertrophic cardiomyopathy (HCM) is a frequent cardiovascular pathology caused by a huge number of mutations in sarcomere-associated proteins. This genetic diversity leads to differences in pathogenetic mechanisms and hampers HCM therapy. Cardiomyocytes derived from patient-specific induced pluripotent stem cells give new opportunities for studying underlying HCM mechanisms. We generated an iPSC line from peripheral blood mononuclear cells of an HCM patient with a heterozygous p.E510Q mutation in HADHA using non-integrating episomal vectors. The iPSC line showed typical morphology, expression of pluripotency markers, capacity to be differentiated into derivatives of three germ layers, and presence of the patient-specific mutation.
This work is devoted to the study of such an interesting phenomenon as levitation of liquid microdroplets above the surface of a heated film. Levitating microdroplets of liquid are formed due to condensation of the upward flow of steam. The height of the drop levitation is comparable to their size. This paper presents new experimental data on the dependence of the droplet diameter on time. Microdroplets of liquid being in a two-dimensional array of microdroplets and levitating above the heated liquid film constantly grow due to condensation. The diameter of the droplets practically linearly increases with time. The obtained non-trivial results require further careful research.
We present an extension of the method of eigenmode decomposition of Gramians proposed earlier for the small-signal stability analysis of dynamical systems. In this paper we derive the spectral decomposition for finite Gramians on any time interval and with arbitrary initial conditions. These expansions allow both a stability analysis of non-stationary systems and a monitoring of instability development in unstable systems. Eigen components in the expansion of Gramians on a finite interval of time we called finite sub-Gramians. Because each sub-Gramian is associated with a particular eigenvector, the sources of instability can be easily localized and tracked in real time. We perform a simulation experiment in which finite sub-Gramians are used to analyze the development of instability arising in an actual power grid on Russky Island when it is disconnected from the mainland network.