Hengzongshu/ArticleAgent huggingface dataset:
The development of power plants focuses on increasing the parameters of water coolants up to a supercritical level. Depressurization of the unit circuits with such a coolant leads to emergency situations. Their scenarios can change significantly with the variation of initial pressure and temperature before the start of depressurization. When the pressure drops from the supercritical single-phase region of the initial thermodynamic parameters of the coolant, either the liquid boils up, or the vapor is condensed. Because of the rapid pressure decrease, the phase transition can be non-equilibrium that must be taken into account in the simulation.

In the present study, an axisymmetric problem of the outflow of a water coolant from the pipe butt-end is considered. The equations of continuity, momentum and energy for a two-phase homogeneous mixture are solved numerically. The vapor and liquid properties are calculated using the TTSE software package (The Tabular Taylor Series Expansion Method). On the basis of the computer complex LCPFCT (The Flux-Corrected Transport Algorithm) the program code was developed for solving numerous problems on the depressurization of vessels or pipelines, containing superheated water or gas under high pressure.

Different variants of outflow in the external model atmosphere and generation of waves are analyzed. The calculated data on the interaction of pressure waves with a barrier are calculated. To describe phase transitions, an asymptotic relaxation model of nonequilibrium evaporation and condensation has been created and tested.
Introduction . The article discusses the problem of using cognitive visceral cardiobiofeedback as a preventive and non-drug method for correcting disturbed regulation mechanisms associated with an increase in blood pressure in adolescents with essential hypertension (EH) against the background of standard antihypertensive therapy with enalapril. Aim of the study was to investigate the indices of the cardiointervalogram (CIG) during a biofeedback session and to evaluate the effectiveness of cardiobiofeedback in healthy adolescents and adolescents with EH living in Novosibirsk. Material and methods . Each participant underwent a 5-minute CIG recording using the hardware and software complex VedaPulse under physiological rest and during biofeedback session. In the course of biofeedback, the subject was asked to lengthen the expiration phase of the respiratory cycle with parallel relaxation of muscle tone and visual feedback on the dynamics of a multimedia plot reflecting changes in the duration of the cardiac cycle. Results and discussion . We found that the effectiveness of cardiorespiratory synchronization (CRS) is characterized by an increase in SDNN indicators by 8.3% and the total power of spectral influences (TP) by 23.6% due to a significant increase in the parasympathetic spectral index of HF by 29.4%. An increase in the power index of the spectrum of low-frequency oscillations (LF) by 51.3% can be considered as an element of CRS within 0,1 Hz. In healthy adolescents, the reactivity of the suprasegmental levels of regulation (IC) is preserved and their growth is noted by 7.6%. In adolescents with EH, an increase in the duration of the cardiac cycle by 5.2% and TP by 31.2% was recorded in the course of cardiobiofeedback, which is associated with an increase in the power of the spectrum of high-frequency oscillations (HF) by 2.4%. This phenomenon should be considered as a positive pathophysiological response of the autonomic link of the nervous system, which is recorded by a decrease in blood pressure. Conclusion . We assume that the test with cognitive visceral cardiobiofeedback can serve as an effective marker for the analysis of the rigidity of autonomic mechanisms of regulation in adolescents with essential hypertension. Conscious regulation of the heart rate through the mechanism of controlled respiration (biofeedback) can be an effective non-drug method for correcting autonomic regulation disorders in adolescents with arterial hypertension, which is manifested by a significant decrease in blood pressure.
The regulation of repair processes including base excision repair (BER) in the presence of DNA damage is implemented by a cellular signal: poly(ADP-ribosyl)ation (PARylation), which is catalysed by PARP1 and PARP2. Despite ample studies, it is far from clear how BER is regulated by PARPs and how the roles are distributed between the PARPs.

Here, we investigated the effects of PARP1, PARP2 and PARylation on activities of the main BER enzymes (APE1, DNA polymerase β [Polβ] and DNA ligase IIIα [LigIIIα]) in combination with BER scaffold protein XRCC1 in the nucleosomal context. We constructed nucleosome core particles with midward- or outward-oriented damage.

It was concluded that in most cases, the presence of PARP1 leads to the suppression of the activities of APE1, Polβ and to a lesser extent LigIIIα. PARylation by PARP1 attenuated this effect to various degrees depending on the enzyme. PARP2 had an influence predominantly on the last stage of BER: DNA sealing. Nonetheless, PARylation by PARP2 led to Polβ inhibition and to significant stimulation of LigIIIα activities in a NAD+-dependent manner. On the basis of the obtained and literature data, we suggest a hypothetical model of the contribution of PARP1 and PARP2 to BER.
We have measured the electric transport properties of TiN nanostrips with different widths.

At zero magnetic field, the temperature-dependent resistance $R(T)$ saturates at a finite resistance toward low temperatures, which results from quantum phase slips in the narrower strips. We find that the current-voltage $(I\text{\ensuremath{-}}V)$ characteristics of the narrowest strips are equivalent to those of small Josephson junctions. Applying a transverse magnetic field drives the devices into a reentrant insulating phase, with $I\text{\ensuremath{-}}V$ characteristics dual to those in the superconducting regime.

The results provide evidence that our critically disordered superconducting nanostrips behave like small self-organized random Josephson networks.
A two-level iterative algorithm for finding stationary solutions of coupled nonlinear Schrödinger equations describing the propagation dynamics of an electromagnetic pulse in multimode and multicore optical fibers of various structures was developed and tested. Using as an example the proposed analytical soliton solution which is localized in space and time, test calculations were performed, and the convergence of the algorithm was demonstrated.
Development of the modern microelectronic equipment requires the effective cooling solutions because it is necessary to remove high heat fluxes of up to 1 kW/cm2 and higher from the local hot spots of the processor. Thin and ultra-thin (less than 10 μm in thickness) liquid films, moving under the action of a forced gas flow in a mini-channel, are promising for the use in the temperature control systems of the modern semiconductor devices. Here we report results of systematic experimental studies of the flow and rupture of a water film, shear-driven in the channel, under intense heating from a local heat source with size of 1x1 cm2. To carry out high-speed visualization of the process, the FASTCAM SA1.1 CCD camera is used (with the speed of up to 100 000 frames per second). The camera is equipped with an optical system of high spatial resolution (2.5 μm per 1 pixel of the camera sensor). With the help of high-speed imaging, it was found that the maximum intensity of heat removal from the heater is achieved in the mode, when the film flow continuity is broken. The heater is covered with dry spots having typical size on the order of 10-100 μm and typical lifetime on the order of 0.1-1 ms. At that, the number of dry spots that exist simultaneously on 1 cm2 of the heater surface can reach several hundred. During 1 s up to 1 million dry spots appear and disappear at the area of the heater.
We present a new experiment management system for the SND detector at the VEPP-2000 collider (Novosibirsk). An important part to report about is access to experimental databases (configuration, conditions and metadata).

The system is designed in client-server architecture. User interaction comes true using web-interface. The server side includes several logical layers: user interface templates; template variables description and initialization; implementation details. The templates are meant to involve as less IT knowledge as possible. Experiment configuration, conditions and metadata are stored in a database. To implement the server side Node.js, a modern JavaScript framework, has been chosen. A new template engine having an interesting feature is designed.

A part of the system is put into production. It includes templates dealing with showing and editing first level trigger configuration and equipment configuration and also showing experiment metadata and experiment conditions data index.
The Electromagnetic Calorimeter (ECAL), one of the main subsystems of the CMS detector, measures the energies of electrons and photons. The ECAL consists of 75848 lead tungstate (PbWO 4 ) crystals. The transparency of crystals is affected by irradiation, and the laser monitoring system is designed to measure the transparency changes for each ECAL crystal over time.

In this work we report the proposed upgrade for the laser monitoring system and the results of computing crystal transparencies based on Run 2 data.

In the future, the High-Luminosity LHC upgrade will increase the integrated luminosuty of the LHC and lead to higher radiation damage in all components of the CMS detector.
The article analyzes the problem of the origin of specific communicative practices that existed on the territory of Siberia in the late 16 th – 17 th centuries and the so-called 'granted word'. This practice was as follows: on behalf of the tsar the authorized person (voivode) communicated with a 'direct proclamation' to his subjects.

Based on the analysis of the Siberian administrative documentation of the 17 th century, the authors identified the categories of addressees of the proclamation on behalf of the monarch. It has been established that by the 1650s in Siberia there was a practice of the proclamation of three versions of the 'granted word'. They were supposed to be proclaimed one by one. The first version was addressed to service people (Boyar sons, Cossacks and Soldiers). The second one was addressed to peasants, traders and craftspeople. The third version was for Siberian natives – yasak-payers.

The paper concludes by arguing that the 'granted word' goes back to the earlier forms of sovereign 'awards', which included measures of encouragement and benefits. Moreover, the set of addressees of the tsarist 'granted word' changed from the end of the 16 th century and depended on the goals of the award, which were set by the central government. During the 1st third of the 17 th century, this particular form of direct address of the tsar to the population of Siberia acquired a new function. The 'granted word' concretized, confirmed and consolidated the rights and obligations for each category of the Siberian population as subjects of the Russian monarch. According to the authors, the reasons for existing such practice on the territory of Siberia are concluded in the specifics of borderability. The monarch sought to additionally legitimate his right to manage this territory and wanted to remind his political influence.
In this work a muon beam profile monitor based on a thin CsI(Tl) screen with optical readout is suggested. This monitor is intended to measure an upcoming surface muon beam to the silica aerogel target of the muon g −2/EDM experiment at J-PARC.

The measurements of luminophore foil parameters with a camera were done as well as the test of the monitor prototype with a surface muon beam at D2 beamline in J-PARC MLF.
We present the first model-independent measurement of the absolute branching fraction of the Λ(c)(+) → pK(-)π(+) decay using a data sample of 978 fb(-1) collected with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider.

The number of Λ(c)(+) baryons is determined by reconstructing the recoiling D((*)-) pπ(+) system in events of the type e(+)e(-) → D((*)-) pπ(+)Λ(c)(+).

The branching fraction is measured to be B(Λ(c)(+) → pK(-)π(+)) = (6.84 ± 0.24(-0.27)(+0.21))%, where the first and second uncertainties are statistical and systematic, respectively.
The quality of the epitaxial structures is significantly influenced by both the initial surface morphology and its transformation during growth. One of the phenomena of surface roughness of silicon occurring during annealing, growth, exposure to electric current, and adsorption of foreign material is the formation of step bunches. The paper presents experimental studies of the transformation kinetics of an atomic step bunches shape on the Si(001) surface that were carried out under electromigration conditions when heated by a constant electric current down the steps in the temperature range of 1000–1150 °С. The samples were annealed in an ultra-high vacuum chamber of a reflection electron microscope, followed by quenching to room temperature. The dependence of the average distance between steps on the number of the bunch steps was observed using an atomic force microscope under atmospheric conditions. It was found that the experimentally obtained dependence obeys a power law (l ∝ Nα), where α varies from –0.68 to –0.36. The study confirmed the change in the elastic interaction potential of steps in bunches with the increase in temperature. The results of the work advance understanding of a bunching process of Si(001) at elevated temperatures.
The asymmetry A_{CP} allows comparison between the mixing probabilities P(B[over ¯]^{0}→B^{0}) and P(B^{0}→B[over ¯]^{0}), and therefore probes CP and T violation.

We present a measurement of the asymmetry A_{CP} between same-sign inclusive dilepton samples ℓ^{+}ℓ^{+} and ℓ^{-}ℓ^{-} (ℓ=e, μ) from semileptonic B decays in ϒ(4S)→BB[over ¯] events, using the complete data set recorded by the BABAR experiment near the ϒ(4S) resonance, corresponding to 471×10^{6} BB[over ¯] pairs.

The result, A_{CP}=[-3.9±3.5(stat)±1.9(syst)]×10^{-3}, is consistent with the standard model expectation.
The Balitsky-Fadin-Kuraev-Lipatov (BFKL) approach for the investigation of semihard processes is plagued by large next-to-leading corrections, both in the kernel of the universal BFKL Green's function and in the process-dependent impact factors, as well as by large uncertainties in the renormalization scale setting. All that calls for an optimization procedure of the perturbative series. In this respect, one of the most common methods is the Brodsky-Lepage-Mackenzie (BLM) one, which eliminates the renormalization scale ambiguity by absorbing the nonconformal ${\ensuremath{\beta}}_{0}$ terms into the running coupling.

In this paper, we apply the BLM scale setting procedure directly to the amplitudes (cross sections) of several semihard processes.

We show that, due to the presence of ${\ensuremath{\beta}}_{0}$ terms in the next-to-leading expressions for the impact factors, the optimal renormalization scale is not universal but depends both on the energy and on the type of process in question.
Linearity of the topological insulator edge state spectrum plays the crucial role for various transport phenomena. The previous studies found that this linearity exists near the spectrum crossing point, but did not determine how perfect the linearity is. The purpose of the present study is to answer this question in various edge states models. We examine Volkov and Pankratov (VP) model [1] for the Dirac Hamiltonian and the model of [2,3] (BHZ1) for the Bernevig, Hughes and Zhang (BHZ) Hamiltonian [4] with zero boundary conditions. It is found that both models yield ideally linear edge states. In the BHZ1 model the linearity is conserved up to the spectrum ending points corresponding to the tangency of the edge spectrum with the boundary of 2D states. In contrast, the model of[5] (BHZ2) with mixed boundary conditions for BHZ Hamiltonian and the 2D tight-binding (TB) model from [4] yield weak non-linearity.
The tests were carried out in the hot-shot wind tunnel IT-302M ITAM SB RAS in the attached pipe-line mode with Men = 3. Numerical simulation was performed using ANSYS FLUENT in a three-dimensional formulation. Satisfactory agreement between the calculated and experimental data is shown. The zones are determined in the section of the combustion chamber with a constant cross-sectional area of possible self-ignition of hydrogen with distributed injection from the pylons from the point of view of satisfying the ignition parameters. Ignition parameters are understood as static pressure and temperature levels, as well as ignition limits for local fuel-air equivalence ratio.
The concept of permanent-magnet variable-period undulator (VPU) was proposed several years ago and has found few implementations so far. The VPUs have some advantages as compared with conventional undulators, e.g., a wider range of radiation wavelength tuning and the option to increase the number of poles for shorter periods.

Both these advantages will be realized in the VPU under development now at Budker INP. In this paper, we present the results of 2D and 3D magnetic field simulations and discuss some design features of this VPU.
Expansion over 200 CGG repeats in FMR1 gene causes inherited intellectual disability or autism spectrum disorder named as fragile X syndrome. Despite the known cause fragile X syndrome pathogenesis has not been specified yet.

The ICGi026-A iPSCs line was obtained by the reprogramming of the peripheral blood mononuclear cells from a 9-year-old boy with fragile X syndrome.

The ICGi026-A iPSCs expressed pluripotency markers, had a normal male karyotype (46, XY) and had the capacity to in vivo differentiate into the cells of three germ layers.
The aim of the study was to investigate the prevalence of angina pectoris (AP) according to the standardized epidemiological questionnaire of Rose in the population of 25–45 years of Novosibirsk and to identify its association with some lipid and non-lipid risk factors for coronary heart disease (CHD).

Material and methods. Cross-sectional survey of the population aged 25–45 in Novosibirsk was carried out. The study included 1439 people (656 men and 783 women). Within the framework of the complex survey program, the standardized epidemiological questionnaire of Rose (WHO, 1984) was used. Blood levels of total cholesterol (total C), triglycerides (TG), low and high density lipoprotein cholesterol (LDL–C, HDL–C) were determinate by biochemical methods.

Results. For all lipid indicators, significant differences were found between men and women. The levels of total C, TG and LDL–C were significantly higher, and the level of HDL–C was lower in men, than in women. According to the Rose questionnaire, out of 1439 people included in the study, 12 patients (0.8%) had AP (75% women). In persons with AP, blood levels of TG were 1.8 times higher, and the levels of HDL–C in blood was 1.2 times lower compared to persons without AP. Univariate analysis of associations of AP with CHD risk factors showed that the chance of developing angina pectoris in the population of 25–45 years was significantly increased in individuals with high blood TG levels (OR 3,515, DI 1,106–11,168, p = 0.039) and low HDL–C (OR 1,203, DI 1,054–1,372, p = 0.006). A natural, although statistically not significant (OR 3,165, p=0,055, due to the small number of groups with AP) increasing in the chance of developing AP in hypertension was detected. Conclusion. In the young population of 25–45 years in Novosibirsk, elevated blood levels of TG, reduced levels of HDL–C, and hypertension were associated with AP, according to Rosecardiological questionnaire, which underlines the importance of conducting screening surveys of the young population to improve effective prevention and treatment of diseases.
The relationship between activation of the sympathetic nervous system and cardiac hypertrophy has long been known. However, the molecular genetic basis of this association is poorly understood. Given the known role of hypothalamic norepinephrine in the activation of the sympathetic nervous system

the aim of the work was to carry out genetic mapping using Quantitative Trait Loci (QTL) analysis and determine the loci associated both with an increase in the concentration of norepinephrine in the hypothalamus and with an increase in heart mass in Inherited Stress-Induced Arterial Hypertension (ISIAH) rats simulating the stress-sensitive form of arterial hypertension

The work describes a genetic locus on chromosome 18, in which there are genes that control the development of cardiac hypertrophy associated with an increase in the concentration of norepinephrine in the hypothalamus, i.e., genes involved in enhanced sympathetic myocardial stimulation. No association of this locus with the blood pressure was found. Taking into consideration previously obtained results, it was concluded that the contribution to the development of heart hypertrophy in the ISIAH rats is controlled by different genetic loci, one of which is associated with the concentration of norepinephrine in the hypothalamus (on chromosome 18) and the other is associated with high blood pressure (on chromosome 1)
One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma.

Rats were randomly divided into three groups: control group, OVA-induced asthma group; OVA-induced asthma + IL10 shRNA interference group. Target gene ( IL10 ) was predicted by ANDSystem. We have demonstrated that RNA-interference of IL10 affected cardiovascular (tested using Millar microcatheter system) as well as respiratory functions (tested using force-oscillation technique, Flexivent) in rats.

We have shown that during RNA-interference of IL10 gene in vivo there were changes in both cardiac and lung function parameters. These changes in the cardiovascular parameters can be described as positive. But the more intensive heart workload can lead to exhaust and decompensation of the heart functions. Knockdown of IL10 gene in asthma modeling induces some positive changes in respiratory functions of asthmatic animals such as decreased elastance and increased compliance of the lungs, as well as less pronounced pathomorphological changes in the lung tissue. Thus, we provide the data about experimentally confirmed functionality changes of the target which was in silico predicted to be associated with both asthma and hypertension – in our new experimental model of comorbid pathology.
We examined methods of controlling the pulse duration, spectral width and wavelength of the output from an all-fiber Yb laser mode-locked by carbon nanotubes. It is shown that a segment of polarization maintaining (PM) fiber inserted into a standard single mode fiber based laser cavity can function as a spectral selective filter. Adjustment of the length of the PM fiber from 1 to 2 m led to a corresponding variation in the pulse duration from 2 to 3.8 ps, the spectral bandwidth of the laser output changes from 0.15 to 1.26 nm. Laser output wavelength detuning within up to 5 nm was demonstrated with a fixed length of the PM fiber by adjustment of the polarization controller.
The results are compared with the literature forecasts in a wide range of angles of inclination.

A method of analytical and numerical calculation of the absorption coefficient was proposed and tested based on the results of a simplified experimental cutting setup.

It was found a significant difference between the absorption coefficients used in the theory and reconstructed their experimental data. The obtained absorption coefficient can be used for further modeling of laser material processing technologies.