Hengzongshu/ArticleAgent huggingface dataset:
The mitochondria-targeted antioxidant SkQ1 is a novel drug thought to retard development of age-related diseases. It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD).

The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. Our results showed that only AhR and AhR -dependent genes were sensitive to SkQ1. Dietary supplementation with SkQ1 decreased the AhR mRNA level in both OXYS and Wistar rats. At baseline, the retinal Cyp1a1 mRNA level was lower in OXYS rats. SkQ1 supplementation decreased the Cyp1a1 mRNA level in Wistar rats, but this level remained unchanged in OXYS rats. Baseline Cyp1a2 and Cyp1b1 mRNA expression was stronger in OXYS than in Wistar rats. In the OXYS strain, Cyp1a2 and Cyp1b1 mRNA levels decreased as a result of SkQ1 supplementation.

These data suggest that the Cyp1a2 and Cyp1b1 enzymes are involved in the pathogenesis of AMD-like retinopathy of OXYS rats and are possible therapeutic targets of SkQ1.
The classical version of spontaneous baryogenesis is studied in details. It is shown that the relation between the time derivative of the (pseudo)goldstone field and the baryonic chemical potential essentially depends upon the representation chosen for the fermionic fields with non-zero baryonic number (quarks). The kinetic equation, used for the calculations of the cosmological baryon asymmetry, is generalized to the case of non-stationary background. The effects of the finite interval of the integration over time are also included into consideration.
CRIC is a high-level information system which provides flexible, reliable and complete topology and configuration description for a large scale distributed heterogeneous computing infrastructure. CRIC aims to facilitate distributed computing operations for the LHC experiments and consolidate WLCG topology information. It aggregates information coming from various low-level information sources and complements topology description with experimentspecific data structures and settings required by the LHC VOs in order to exploit computing resources. Being an experiment-oriented but still experiment-independent information middleware, CRIC offers a generic solution, in the form of a suitable framework with appropriate interfaces implemented, which can be successfully applied on the global WLCG level or at the level of a particular LHC experiment. For example there are CRIC instances for CMS[11] and ATLAS[10]. CRIC can even be used for a special task. For example, a dedicated CRIC instance has been built to support transfer tests performed by DOMA Third Party Copy working group. Moreover, extensibility and flexibility of the system allow CRIC to follow technology evolution and easily implement concepts required to describe new types of computing and storage resources. The contribution describes the overall CRIC architecture, the plug-in based implementation of the CRIC components as well as recent developments and future plans.
Oct4 is a POU-domain transcriptional factor which is essential for maintaining pluripotency in several mammalian species. The mouse, human, and bovine Oct4 orthologs display a high conservation of nucleotide sequence and genomic organization.Here we report an isolation of a common vole (Microtus rossiaemeridionalis) Oct4 ortholog. Organization and exon-intron structure of vole Oct4 gene are similar to the gene organization in other mammalian species. It consists of five exons and a regulatory region including the minimal promoter, proximal and distal enhancers. Promoter and regulatory regions of the vole Oct4 gene also display a high similarity to the corresponding regions of Oct4 in other mammalian species, and are active during the transient transfection within luciferase reporter constructs into mouse P19 embryonic carcinoma cells and TG-2a embryonic stem cells. The vole Oct4 gene expression is detectable starting from the morula stage and until day 17 of embryonic development.Genomic organization of this gene and its intron-exon structure in vole are identical to those in all previously studied species: it comprises five exons and the regulatory region containing several conserved elements. The activity of the Oct4 gene in vole, as well as in mouse, is confined only to pluripotent cells.
In scanning interferometry of longitudinal shift, an uncertainty of required phase shift performance leads to a measurement error. Such uncertainty can be caused by external factors (vibrations, air turbulence in measuring area etc.) as well as inaccuracy of the scanning system. The method for calculating the phase shift between interferograms, which allows reducing the measurement error, is proposed. The results of numerical and full scale experiments are presented.
Recent measurements of exclusive hadronic cross sections in $e^+e^-$ experiments important for calculation of the leading-order hadronic contribution to the muon anomalous magnetic moment are reviewed.
It is assumed that equivalent stresses in the runner are below the critical value after which irreversible plastic processes happen in the runner material. Therefore runner is subjected to the fatigue damage caused by high-cycle fatigue, in which the loads are generally low compared with the limit stress of the material. As a consequence, the stress state around the crack front can be fully characterized by linear elastic fracture mechanics.

The unsteady 3D flow is modeled simultaneously in the spiral chamber, each wicket gate and runner channels and in the draft tube using the Euler equations. Based on the unsteady runner loadings at each time step stresses in the whole runner are calculated using the elastic equilibrium equations solved with boundary element method. Set of static stress-strain states provides quasi-dynamics of runner cyclic loading.

The place of runner cracking is determined as a point with maximal amplitude of stress oscillations. Stress pulsations amplitude is used to estimate the number of cycles until the moment of fatigue failure, number of loading cycles and oscillation frequency are used to calculate runner service time. Example of the real Francis runner which has encountered premature fatigue failure as a result of incorrect durability estimation is used to verify the developed numerical model.
The contribution summarizes the results of recent studies of phase transitions induced by high pressure in a number of molecular organic crystals, such as polymorphs of paracetamol, chlorpropamide, polymorphs of glycine, L- and DL-serine, β-alanine.

The main attention is paid to the following topics: (1) Reversible / irreversible transformations; (2) Different behavior of single crystals / powders; (3) The role of pressure-transmitting liquid; (4) The role of the kinetic factors: phase transitions on decompression, or after a long storage at a selected pressure; (5) Isosymmetric phase transitions; (6) The role of the changes in the hydrogen bond networks / intramolecular conformational changes in the phase transitions; (7) Superstructures / nanostructures formed as a result of pressure-induced phase transitions.
The paper proposes a pattern recognition method using a modification of the class of logical decision functions presented in the form of decision tree.

Instead of standard statements corresponding to the tree nodes, in which a variable is tested for a certain set of its values, a more general type of statements is used regarding the similarity of the point in question to different subsets of the observations. At the same time, to determine the degree of similarity, various metrics and subspaces of features can be used. This type of decision tree allows one to obtain more complex decision boundaries, which at the same time have a clear logical interpretation for the user. Several tree induction strategies are considered based on data transformation using support points selected with Relief, SVM, and k -means procedures. The method is experimentally investigated on the problem of tomographic images analysis, as well as on several synthetic datasets.

Experiments have shown that the proposed method gives more accurate predictions than CART, SVM, kNN classifiers and deep convolutional neural network (AlexNet).
Objective: To study responsibility, as one of the stress parameters in workplace, in males and females of open urban population from a gender perspective. Design and method: The study was conducted as a part of cardiological screening in open workable population of both sexes aged 25–64 years in Tyumen. A representative sample was formed from voting lists of 2,000 citizens of one of the administrative districts of Tyumen, 250 people in each of eight groups defined by sex and age (25–34, 35–44, 45–54, 55–64). Response to cardiac screening was 77.7%. To analyze stress at work, questionnaire WHO MONICA-psychosocial “Knowledge and attitude to your health” was applied. In this study, questions regarding workplace responsibility were used to determine stress in the workplace. Results: Statistically significant differences in answers to a question “Has your responsibility at work changed in the past 12 months?” were registered at young age in favor of women (25–34 years: 37.5–54.9%; 35–44: 39.5–53.1% in males and females, respectively, p < 0.01). Over the past 12 months, work responsibility was rated as “insignificant” by 7.9% of males and 3.4% of females in open population, p < 0.001. Similar trends in males and females in relation to this category of answers were detected in age groups of 25–34 (5.7–0.8%, p < 0.05) and 55–64 (18.7–3.7%, p < 0.001). Self-assessment of work responsibility as “high” over the past 12 months was significantly more often detected among females compared to males in general population (53.6–45.2%, p < 0.001) and in elder age group 55–64 (52.8–32.7%, p < 0.001). Conclusions: In open urban population, according to the model of Tyumen city, the highest self-assessment of responsibility in workplace was registered in females, mainly in elder group, and increased work responsibility as in elder age group 55–64 so as predominantly in females younger than 45 years. Thus, generating informational and educational technologies for heart diseases prevention in adult population of the city, top-priority orientation is to be focused on needs of “social risk” groups in population, exactly in young workable females.
Helical vortices whose parameters have a strong influence on the efficiency of the apparatus is often occur in technical devices using swirling flow (cyclones, separators, etc.). To date the internal structure of such vortices is poorly understood. In [1] a model of helical vortex with uniform vorticity distribution in the core is proposed. Vortices arising in real flow always have a smooth vorticity distribution due to the viscosity action. The problem on steady moving helical vortices with the vortex core of small size in an inviscid fluid was solved in [2]. The non-orthogonal ‘helical’ coordinate system was introduced that allowed author to reduce the problem to two dimensional one. However, the velocity of the vortex motion was written only in the form of a quadratures computation of which is difficult. This paper presents first attempt for research on the diffusion and dynamics of a viscous helical vortex.
Arctic regions contain significant amounts of natural resources; however, the level of hydrocarbon resources exploration in the region is quite low, which increases the prospect of geological exploration and discovery of new hydrocarbon deposits. The authors studied the features of socio-economic, infrastructural and resource-raw development of the Arctic regions using such indicators as population density, per capita incomes, gross regional product, investments in fixed assets, transport infrastructure, reserves and oil and gas production. It is shown that there is a high differentiation of the regions development in relation to the average Russian indicator. The article considers the state stimulation instruments of oil production in the Arctic regions, with special attention paying to tax benefits. With using cluster analysis, all regions of Russia are divided into groups on tax burden and benefits. The Arctic resource regions are shown to be distributed over two clusters: regions that have a high tax burden due to significant oil production (some of them are traditional and receive fewer benefits); regions that receive significant benefits from the government to intensify oil production. Thus, the analysis revealed that preferential rates for specific industry taxes can be an effective tool for government regulation of strategic industries.
The primary objective of personalized vaccination is to induce an efficient immune defense while avoiding excessive immunization. Hence, it necessitates the development of methods for predicting the magnitude of the immune response prior to vaccination. Telomere length can be considered as a promising prognostic parameter for assessing the immune response to vaccination.

The aim of the work was to analyze the possible association between leukocyte telomere length and specific antibody levels after vaccination against tick-borne encephalitis. The study included 55 men and 40 women who had not previously been vaccinated against tick-borne encephalitis and had no contacts with ticks. Vaccination was carried out with the EnceVir vaccine. One month after vaccination, the level of specific IgG antibodies against tick-borne encephalitis virus was analyzed using the VektoVKE-IgG-strip test system and leukocyte telomere length was measured using real-time quantitative PCR. According to the intensity of vaccine-elicited immune responses, patients were divided into three groups: unresponsive (IgG level 0–100 IU/ml), slightly responsive (IgG level 101–200 IU/ml) and highly responsive (IgG level above 200 IU/ml).

The telomere length, at least at trend level ( p < 0.1), correlated with the response to vaccination as well as age, educational level and the presence of emotional stress. Using a general linear model, an association between telomere length and immune response to vaccination against tick-borne encephalitis at trend level ( p < 0.1) was found only in women. Using a pairwise comparison, it was found that telomere length was significantly higher in highly responsive women than in unresponsive women. Hence, an association between leukocyte telomere length and specific antibody levels after vaccination against tick-borne encephalitis was identified in women. Therefore, peripheral blood leukocyte telomere length can be considered as a promising marker for predicting lymphocyte proliferative responses and the magnitude of vaccine-elicited cellular immune responses.
ABSTRACT Gene-based association analysis is an effective gene mapping tool. Many gene-based methods have been proposed recently. However, their power depends on the underlying genetic architecture, which is rarely known in complex traits, and so it is likely that a combination of such methods could serve as a universal approach. Several frameworks combining different gene-based methods have been developed. However, they all imply a fixed set of methods, weights and functional annotations. Moreover, most of them use individual phenotypes and genotypes as input data. Here, we introduce sumSTAAR, a framework for gene-based association analysis using summary statistics obtained from genome-wide association studies (GWAS). It is an extended and modified version of STAAR framework proposed by Li and colleagues in 2020. The sumSTAAR framework offers a wider range of gene-based methods to combine. It allows the user to arbitrarily define a set of these methods, weighting functions and probabilities of genetic variants being causal. The methods used in the framework were adapted to analyse genes with large number of SNPs to decrease the running time. The framework includes the polygene pruning procedure to guard against the influence of the strong GWAS signals outside the gene. We also present new improved matrices of correlations between the genotypes of variants within genes. These matrices estimated on a sample of 265,000 individuals are a state-of-the-art replacement of widely used matrices based on the 1000 Genomes Project data. AUTHOR SUMMARY Gene-based association analysis is an effective gene mapping tool. Quite a few frameworks have been proposed recently for gene-based association analysis using a combination of different methods. However, all of these frameworks have at least one of the disadvantages: they use a fixed set of methods, they cannot use functional annotations, or they use individual phenotypes and genotypes as input data. To overcome these limitations, we propose sumSTAAR, a framework for gene-based association analysis using GWAS summary statistics. Our framework allows the user to arbitrarily define a set of the methods and functional annotations. Moreover, we adopted the methods for the analysis of genes with a large number of SNPs to decrease the running time. The framework includes the polygene pruning procedure to guard against the influence of the strong GWAS signals outside the gene. We also present new improved matrices of correlations between the genotypes of variants within genes, which now allows to include ultra-rare variants in analysis.
The number of people with inﬂammatory bowel disease (IBD) is constantly increasing worldwide. The main factors that have eﬀects on the etiology of the disease are genetic, environmental and immunological. However, the mechanism of disease development and eﬀective treatment of IBD have not yet been found. Animal models help address these problems. The most popular model is considered to be transgenic models in which individual genes are knocked out. One of such models for the study of IBD are mice with a null mutation of the Muc2 gene encoding the Mucin-2 protein, which is involved in the formation of a protective mucin layer in the small and large intestine. Some of transcription factors that change the expression of intestinal genes are involved in the development of IBD and colorectal cancer. One of such transcription factors is “zinc fnger” domain-containing protein Kaiso which is able to bind to methylated DNA. In this study, we assessed the role of Kaiso in the development of intestinal inﬂammation using the experimental model of C57BL/6 Muc2 -/- Kaiso -/-. We have shown that mice with impaired intestinal barrier function that develop processes similar to human IBD also develop inﬂammatory responses, such as increased expression of Il1 , Tnf and Il17a genes. The defciency of the Kaiso transcription factor in Mucin-2 knockout mice causes a decrease in the expression level of only the Cox2 and T ﬀ 3 genes. Perhaps a decline in the expression of the gene encoding cyclooxygenase-2 can lead to a decrease in the expression of the antibacterial factor Trefoil factor 3. However, in the experimental model of IBD, Kaiso protein did not play a signifcant role in the regulation of pro-inﬂammatory cytokines of tumor necrosis factor and interleukins 1 and 17.
Let ρ be a metric on a space X and let s ≥ 1. The function ρ^s(a,b)=ρ(a,b)^s is a quasimetric (it need not satisfy the triangle inequality). The function inf ρ^s(a,b) defined by the condition inf ρ^s(a,b)=inf{∑_0^n ρ^s(z_i,z_{i+1}) z_0=a, z_n=b} is a pseudometric (i.e., satisfies the triangle inequality but can be degenerate).

We show how this degeneracy can be connected with the Hausdorff dimension of the space (X,ρ).

We also give some examples showing how the topology of the space (X, inf ρ^s) can change as s changes.
In this paper, we develop a new method to produce explicit formulas for the number fG(n) of rooted spanning forests in the circulant graphs G = Cn(s1,s2,…,sk) and G = C2n(s1,s2,…,sk,n).

These formulas are expressed through Chebyshev polynomials. We prove that in both cases the number of rooted spanning forests can be represented in the form fG(n) = p a(n)2, where a(n) is an integer sequence and p is a certain natural number depending on the parity of n.

Finally, we find an asymptotic formula for fG(n) through the Mahler measure of the associated Laurent polynomial P(z) = 2k + 1−∑i = 1k(zsi+z−si).
The current pilot study investigated the psychological mechanisms behind ethnic outgroup aggression, a significant outcome of intergroup conflicts. While previous research suggested several impactful predictors of ethnic outgroup aggression, such as intergroup contact and nationalism, no attempt has been made to synthesize all these constructs into a single cross-cultural study. Building on existing research, this pilot study is the first to assess a refined framework where we tested a proposed mediation model according to nationalism and emotion regulation mediate the relationship between intergroup contact, susceptibility to persuasion, and intergroup anxiety on the one hand and ethnic outgroup aggression on the other hand within a cross-cultural sample. An online questionnaire was distributed using convenience sampling among 2482 students with an ethnic majority background living and studying in ten (European) countries. Multigroup path analysis supported the larger part of the hypothesized model where we found that emotion regulation partially mediated the relationship between susceptibility to persuasion as a predictor and aggression as an outcome. As expected, we found that the higher the susceptibility to persuasion, the higher the emotion regulation, and the higher the regulation, the lower the aggression in all countries. Our pilot study provided preliminary evidence that emotion regulation, nationalism and susceptibility to persuasion are critical for the understanding of ethnic outgroup aggression in ethnically diverse societies. Future research needs to be carried out focusing on the development of an intergroup anxiety assessment in which possible gender differences in assessed constructs are considered.
Swirling flow with a precessing vortex core (PVC) was investigated using a laser Doppler anemometer and pressure pulsation sensors.

The experiments were conducted on aerodynamic and hydrodynamic test rigs over a wide range of hydraulic turbine operating conditions. Part-load modes of hydraulic turbine operation were investigated using the Fourier transform of pressure pulsations obtained from acoustic sensors.

The features of the swirling flow were shown for the range of operating conditions from deep part-load to overload.