Hengzongshu/ArticleAgent huggingface dataset:
Antiviral activity of the new chemically synthesized compound NIOCH-14 (a derivative of tricyclodicarboxylic acid) in comparison with ST-246 (the condensed derivative of pyrroledione) was observed in experiments in vitro and in vivo using orthopoxviruses including highly pathogenic ones.

After oral administration of NIOCH-14 to outbred ICR mice infected intranasally with 100 % lethal dose of ectromelia virus, it was shown that 50 % effective doses of NIOCH-14 and ST-246 did not significantly differ. The 'therapeutic window' varied from 1 day before infection to 6 days post-infection (p.i.) to achieve 100–60 % survival rate. The administration of NIOCH-14 and ST-246 to mice resulted in a significant reduction of ectromelia virus titres in organs examined as compared with the control and also reduced pathological changes in the lungs 6 days p.i. Oral administration of NIOCH-14 and ST-246 to ICR mice and marmots challenged with monkeypox virus as compared with the control resulted in a significant reduction of virus production in the lungs and the proportion of infected mice 7 days p.i. as well as the absence of disease in marmots. Significantly lower proportions of infected mice and virus production levels in the lungs as compared with the control were demonstrated in experiments after oral administration of NIOCH-14 and ST-246 to ICR mice and immunodeficient SCID mice challenged with variola virus 3 and 4 days p.i., respectively.

The results obtained suggest good prospects for further study of the chemical compound NIOCH-14 to create a new smallpox drug on its basis.
A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13 TeV recorded with the ATLAS detector.

The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ^{+}τ^{-} decay with at least one τ-lepton decaying into final states with hadrons.

The data are in good agreement with the background prediction of the standard model. In the M_{h}^{125} scenario of the minimal supersymmetric standard model, values of tanβ>8 and tanβ>21 are excluded at the 95% confidence level for neutral Higgs boson masses of 1.0 and 1.5 TeV, respectively, where tanβ is the ratio of the vacuum expectation values of the two Higgs doublets.
Multiscale approaches for integrating submodels of various levels of biological organization into a single model became the major tool of systems biology. In this paper, we have constructed and simulated a set of multiscale models of spatially distributed microbial communities and study an influence of unevenly distributed environmental factors on the genetic diversity and evolution of the community members. Haploid Evolutionary Constructor software http://evol-constructor.bionet.nsc.ru/ was expanded by adding the tool for the spatial modeling of a microbial community (1D, 2D and 3D versions). A set of the models of spatially distributed communities was built to demonstrate that the spatial distribution of cells affects both intensity of selection and evolution rate. In spatially heterogeneous communities, the change in the direction of the environmental flow might be reflected in local irregular population dynamics, while the genetic structure of populations (frequencies of the alleles) remains stable. Furthermore, in spatially heterogeneous communities, the chemotaxis might dramatically affect the evolution of community members.
The fragmentation of high-energy gluons at small opening angles is largely unconstrained by present measurements. Gluon splitting to $b$-quark pairs is a unique probe into the properties of gluon fragmentation because identified $b$-tagged jets provide a proxy for the quark daughters of the initial gluon. In this study, key differential distributions related to the $g\ensuremath{\rightarrow}b\overline{b}$ process are measured using $33\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of $\sqrt{s}=13\text{ }\text{ }\mathrm{TeV}$ $pp$ collision data recorded by the ATLAS experiment at the LHC in 2016. Jets constructed from charged-particle tracks, clustered with the anti-${k}_{t}$ jet algorithm with radius parameter $R=0.2$, are used to probe angular scales below the $R=0.4$ jet radius. The observables are unfolded to particle level in order to facilitate direct comparisons with predictions from present and future simulations. Multiple significant differences are observed between the data and parton shower Monte Carlo predictions, providing input to improve these predictions of the main source of background events in analyses involving boosted Higgs bosons decaying into $b$-quarks.
We say that finite groups are isospectral if they have the same sets of orders of elements. It is known that every nonsolvable finite group G isospectral to a finite simple group has a unique nonabelian composition factor, that is, the quotient of G by the solvable radical of G is an almost simple group. The main goal of this paper is to prove that this almost simple group is a cyclic extension of its socle. To this end, we consider a general situation when G is an arbitrary group with unique nonabelian composition factor, not necessarily isospectral to a simple group, and study the prime graph of G, where the prime graph of G is the graph whose vertices are the prime numbers dividing the order of G and two such numbers r and s are adjacent if and only if r≠s and G has an element of order rs. Namely, we establish some sufficient conditions for the prime graph of such a group to have a vertex adjacent to all other vertices. Besides proving the main result, this allows us to refine a recent result by Cameron and Maslova concerning finite groups almost recognizable by prime graph.
Various clinical scenarios of the course of the post-COVID syndrome in the period of convalescence were studied. The frequency and volume of studies in combined pathology in patients who have undergone COVID-19 are considered.

The controlled indicators of the medical state within the framework of follow-up monitoring and the minimum frequency of follow-up visits were clarified.

Key words: New coronavirus infection, convalescents, the long COVID syndrome, follow-up monitoring
Spatial self-imaging, consisting of the periodic replication of the optical transverse beam profile along the propagation direction, can be achieved in guided wave systems when all excited modes interfere in phase.

We exploited material defects photoluminescence for directly visualizing self-imaging in a few-mode, nominal singlemode SMF-28 optical fiber. Visible luminescence was excited by intense femtosecond infrared pulses via multiphoton absorption processes.

Our method permits us to determine the mode propagation constants and the cutoff wavelength of transverse fiber modes.
We report the results of the feasibility study of using LoRa modulation for radio communications between CubeSat at low Earth orbit and ground station. The main goal of the study is to define how Doppler effect affects a LoRa radio link. Results of laboratory testing have shown high immunity of LoRa radio link to Doppler shift and a possibility to use LoRa modulation in CubeSat radio communications without any limitations.
Results are presented from a search for the pair production of third-generation squarks in proton-proton collision events with two-body decays to bottom or charm quarks and a neutralino, which produces a significant imbalance in the transverse momentum. The search is performed using a sample of proton-proton collision data at sqrt(s) = 13 TeV recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9 inverse femtobarns. No statistically significant excess of events is observed beyond the expected contribution from standard model processes. Exclusion limits are set in the context of simplified models of bottom or top squark pair production. Models with bottom squark masses up to 1220 GeV are excluded at 95% confidence level for light neutralinos, and models with top squark masses of 510 GeV are excluded assuming that the mass splitting between the top squark and the neutralino is small.
The genome of a red fox (Vulpes vulpes) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which are likely to contain assembly errors. Fragmentation and misassembly hinder accurate gene prediction and downstream analysis such as the identification of loci under selection.

Therefore, assembly of the genome into chromosome-scale fragments was an important step towards developing this genomic model. Scaffolds from the assembly were aligned to the dog reference genome and compared to the alignment of an outgroup genome (cat) against the dog to identify syntenic sequences among species. The program Reference-Assisted Chromosome Assembly (RACA) then integrated the comparative alignment with the mapping of the raw sequencing reads generated during assembly against the fox scaffolds. The 128 sequence fragments RACA assembled were compared to the fox meiotic linkage map to guide the construction of 40 chromosomal fragments.

This computational approach to assembly was facilitated by prior research in comparative mammalian genomics, and the continued improvement of the red fox genome can in turn offer insight into canid and carnivore chromosome evolution. This assembly is also necessary for advancing genetic research in foxes and other canids.
The influence of a stoichiometric amount of ionic liquids (IL) on the fluorination of phenols in various solvents has been studied.

The fluorination of phenol, 1-naphthol and resorcinol was carried out using 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF 4 , Selectfluor™) with the formation of 2-fluoro-, 4-fluorophenol, 2-fluoro-, 4-fluoronaphthol and 4-fluoro-, 4,6-difluoro-benzene-1,3-diol as the main products. The use of a stoichiometric amount of ionic liquid as an additive results in acceleration of the reactions. The effect is most significant at low temperatures.

It has been found that solvent polarity has an essential effect on the difference in yields of fluoroproducts obtained in the presence of IL and without it.
In this paper, we prove the following theorem:If a graph X is a degree 2 (unramified) covering of a hyperelliptic graph of genus g >= 2, then X is gamma-hyperelliptic for some gamma <= [(g-1)/2]. This is a discrete analogue of the corresponding theorem for Riemann surfaces. The Bass-Serre theory of coverings of graphs of groups is employed to get the main result.
The presence of the higher triplet state in C70 is in good agreement with the previous results from phosphorescence spectroscopy.

Spin-lattice relaxation times T1 of photoexcited triplets (3)C70 in glassy decalin were obtained from electron spin echo inversion recovery dependences. In the range 30-100 K, the temperature dependence of T1 was fitted by the Arrhenius law with an activation energy of 172 cm(-1).

This indicates that the dominant relaxation process of (3)C70 is described by an Orbach-Aminov mechanism involving the higher triplet state t2 which lies 172 cm(-1) above the lowest triplet state t1. Chemical modification of C70 fullerene not only decreases the intrinsic triplet lifetime by about ten times but also increases T1 by several orders of magnitude. The reason for this is the presence of a low-lying excited triplet state in (3)C70 and its absence in triplet C70 derivatives.
Since most probably Standard Model cannot explain large value of CP asymmetries recently observed in D-meson decays

the fourth quark-lepton generation explanation of it is proposed

As a byproduct weakly mixed leptons of the fourth generation enable to save the baryon number of the Universe from erasure by sphalerons
The article is devoted to the analysis of ethnic scientific communities. Based on the analysis of research literature, the author comes to the conclusion that there is a local, ethnic nature of the specificity of scientific communities. This specificity is manifested primarily in the formation of a kind of “image of science and scientist”, which is especially pronounced in modernizing societies. The obtained theoretical results are illustrated by the example of the formation, evolution and current state of the scientific and educational communities of the republics of Siberia (Tuva, Khakassia, Buryatia, Altai). It is proved that the specifics of their post-Soviet development is largely due to Soviet experience, in particular when it comes to the place of a scientist in a traditional and modernized society, the role of science and education as a social elevator, the place of spheres of intellectual production in the modern social and economic structure of these regions.
The production of J/ψ mesons accompanied by open charm hadrons, and of pairs of open charm hadrons in pp collisions at a centre-of-mass energy of 7 TeV has been reported in ref. [1].

For all measured production cross-sections the inclusion of charge conjugate processes was implied, so that e.g.,
The charge transport mechanism in amorphous oxide semiconductors (AOS) is a matter of controversial debates. Most theoretical studies so far neglected the percolation nature of the phenomenon.

In this paper, a recipe for theoretical description of charge transport in AOSs is formulated using the percolation arguments.

Comparison with the previous theoretical studies shows a superiority of the percolation approach. The results of the percolation theory are compared to experimental data obtained in various InGaZnO materials revealing parameters of the disorder potential in such AOS.
A report on the scientific and practical conference held on November 1–2, 2021 in Novosibirsk State University is presented. The conference has an international status, because of 23 foreign participants from 5 countries.

A wide range of topical issues related to history, archaeology, economy and culture of China, to studying and teaching Chinese etc. was discussed at the conference.

And among the speakers on the plenary was presented online our special guest Daniel Waugh, Professor Emeritus of the Washington State University.
Personal-possessive 1st and 2nd person singular noun affixes in the Surgut dialect of the Khanty language, as well as 1st person plural noun affixes (irregular in various dialects) with singular objects are represented by several allomorphs: 1SG.SG ‒ =əм / =эм / =ам; 2SG.SG ‒ =əн / =э (=эн) / =а; 1PL.SG ‒ (?)=əв / =эв / =ив / =ув / =ав.

Our research is based on field materials collected in the Surgut District, Khanty-Mansi Autonomous Okrug, or Yugra, in 2017‒2019. The audio records were segmented and annotated in the Praat software. Acoustic analysis and further statistical analysis of our data was performed on the basis of Emu-SDMS corpus system and R language.

When the personal-possessive affixes are attached, vowel alternation occurs in several roots. The choice of specific allomorphs and the presence or absence of alternation depends on the root vowels. In roots with short vowels, there is no alternation, and affixes with lower vowels are used: =ам (1SG.SG) and =а (1SG.SG). When the personal-possessive affixes are attached to roots with long vowels, lower vowels are replaced by corresponding upper vowels. After roots with long upper vowels, =эм (1SG.SG) and =э (2SG.SG) affix variants are used, and no alternation occurs, because vowels can no longer be ‘moved’ upwards. After stems with long non-upper vowels, the =əм (1SG.SG) and =əн (2SG.SG) affixes are used, and alternation takes place in the root. This is not true for some specific cases: in roots with long middle vowels, these processes may occur according to the upper vowel model, or the lower vowel model; for example, the lexeme вӧӈ ‘son-in-law’, which contains a short vowel, can be followed by affixes with the vowel э, typical for roots with long upper vowels.
Development of collective intelligence and consciousness starts playing key evolutionary role given spread of social networks and massive Internet communications.

Paper considers cognitive model and architecture capable to capture cognitive phenomena in social environments, which could be used for modeling of collective cognition as well as developing practical applications for individual interaction with collective intelligence.

The model is evaluated by means of qualitative and quantitative experiments.
The article presents accurate solutions for the problem for two elastic half‐spaces with an arbitrary curvilinear interface.

Our study shows that dilatation solutions (Poisson integrals) are dependent on neither an overall compression modulus nor the Poisson ratio, and depend only on the velocity of longitudinal waves. These specific solutions can be supplemented by general solutions for an incompressible elastic medium, and the boundary conditions of the rigid contact for the sum of the solutions can thus be satisfied. Relatively simple calculations make it possible to determine the divergence of the displacement field and reduce the entire problem solving process to a study of Poisson equations with a known divergence.

Furthermore, predictions of volumetric compression or extension are important for geological investigations, since the zones characterized by reduced pressure rates may act as fluid attractors.
Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP).

The Rh/TiO 2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years.

3D 1 H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm 3 ) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.
The research identifies and substantiates the problem of quality deterioration in the sentiment classification of text collections identical in composition and characteristics, but staggered over time. It is shown that the quality of sentiment classification can drop up to 15% in terms of the F-measure over a year and a half. This paper presents three different approaches to improving text classification by sentiment in continuously-updated text collections in Russian: using a weighing scheme with linear computational complexity, adding lexicons of emotional vocabulary to the feature space and distributed word representation. All methods are compared, and it is shown which method is most applicable in certain cases. Experiments comparing the methods on sufficiently representative text collections are described. It is shown that suggested approaches could reduce the deterioration of sentiment classification results for collections staggered over time.
Characterization of the complex spatiotemporal dynamics of optical beam propagation in nonlinear multimode fibers requires the development of advanced measurement methods, capable of capturing the real-time evolution of beam images. We present a new space–time mapping technique, permitting the direct detection, with picosecond temporal resolution, of the intensity from repetitive laser pulses over a grid of spatial samples from a magnified image of the output beam. By using this time-resolved mapping, we provide, to the best of our knowledge, the first unambiguous experimental observation of instantaneous intrapulse nonlinear coupling processes among the modes of a graded index fiber.
Coronavirus SARS-CoV-2 caused the pandemic of COVID-19, a respiratory disease with relatively high mortality.It is important to understand the extent to which health-related factors influence on the risk of severe COVID-19 symptoms development.It can help the health care system to save more lives, and governments to take reasonable actions.

We aimed to estimate the associations between the severity of COVID-19 infection and previously suggested health-related risk factors using the methods of human quantitative genetics.First, we collected summary statistics of one GWAS for COVID-19 severity and of 6 GWASes for previously suggested risk factors.We unified summary statistics from these analyses, performed quality control, and imported the data to the GWAS-MAP platform.Then, using these summary statistics we performed Mendelian randomization analysis and obtained the estimates of associations between COVID-19 severity and several previously suggested risk factors.

Although our estimates of Odds Ratio are directionally consistent with previous estimates obtained from retrospective epidemiological studies, they are not significant.
Background The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, which regulates the efficiency of dendritic mRNA translation in response to stimulation of metabotropic glutamate receptors at excitatory synapses of the hippocampal pyramidal cells. Its activity is regulated via positive and negative regulatory loops that function in different time ranges, which is an absolute factor for the formation of chaotic regimes that lead to disrupted proteome stability. The indicated condition may cause a number of neuropsychiatric diseases, including autism and epilepsy. The present study is devoted to a theoretical analysis of the local translation system dynamic properties and identification of parameters affecting the chaotic potential of the system. Results A mathematical model that describes the maintenance of a specific pool of active receptors on the postsynaptic membrane via two mechanisms – de novo synthesis of receptor proteins and restoration of protein function during the recycling process – has been developed. Analysis of the model revealed that an increase in the values of the parameters describing the impact of protein recycling on the maintenance of a pool of active receptors in the membrane, duration of the signal transduction via the mammalian target of rapamycin pathway, influence of receptors on the translation activation, as well as reduction of the rate of synthesis and integration of de novo synthesized proteins into the postsynaptic membrane – contribute to the reduced complexity of the local translation system dynamic state. Formation of these patterns significantly depends on the complexity and non-linearity of the mechanisms of exposure of de novo synthesized receptors to the postsynaptic membrane, the correct evaluation of which is currently problematic. Conclusions The model predicts that an increase of “receptor recycling” and reduction of the rate of synthesis and integration of de novo synthesized proteins into the postsynaptic membrane contribute to the reduced complexity of the local translation system dynamic state. Herewith, stable stationary states occur much less frequently than cyclic states. It is possible that cyclical nature of functioning of the local translation system is its “normal” dynamic state.