Hengzongshu/ArticleAgent huggingface dataset:
Background: Plasma enriched in growth factors is widely used in medical practice. However, the clinical efficacy of its application in the treatment of age-related retinal integrity violations is investigated insufficiently. Aims: The aim of the study was to evaluate the clinical efficacy of autologous plasma enriched with platelet lysate for treating age-related macular degeneration. Materials and methods: A three-port subtotal transconjunctival vitrectomy was performed and administration of the autologous plasma enriched with platelet lysate was indicated. Autologous plasma enriched with platelet lysate was received from the peripheral blood. We assessed visual acuity, intraocular pressure; conducted optical coherent tomography examination of the eye on the side of the pathological process. Results: The study demonstrated that the combination of a standard 3-port transconjunctival subtotal vitrectomy followed by tamponade of the gap using the autologous plasma enriched with platelet lysate with the injections of the autologous plasma enriched with platelet lysate in the area of pterygopalatine fossa on the side of the operated eyes statistically significantly promoted recovery of the visual acuity in the early postoperative period (15 days) and late period (90 days) if compared with patients who received only surgical treatment (p≤0.05). Use of the autologous plasma enriched with platelet lysate in the treatment increased the closing rate of the tearing of the retina in the macular region up to 62,5%, while only surgical treatment leads to the closure of the defect of the retina in 37.5% of cases. The study showed that autologous plasma enriched with platelet lysate contains cytokines, growth factors, and nitric oxide which are involved in the regeneration/reparation of the retina. Conclusions: Additional administration of the autologous plasma enriched with platelet lysate in the scheme of treatment patients with age-related macular degeneration is accelerating the closure of retinal tears of the eye and improves visual acuity.
Sufficient boron-10 isotope (10B) accumulation by tumor cells is one of the main requirements for successful boron neutron capture therapy (BNCT). The inability of the clinically registered 10B-containing borophenylalanine (BPA) to maintain a high boron tumor concentration during neutron irradiation after a single injection has been partially solved by its continuous infusion; however, its lack of persistence has driven the development of new compounds that overcome the imperfections of BPA.

We propose using elemental boron nanoparticles (eBNPs) synthesized by cascade ultrasonic dispersion and destruction of elemental boron microparticles and stabilized with hydroxyethylcellulose (HEC) as a core component of a novel boron drug for BNCT. These HEC particles are stable in aqueous media and show no apparent influence on U251, U87, and T98G human glioma cell proliferation without neutron beam irradiation. In BNCT experiments, cells incubated with eBNPs or BPA at an equivalent concentration of 40 µg 10B/mL for 24 h or control cells without boron were irradiated at an accelerator-based neutron source with a total fluence of thermal and epithermal neutrons of 2.685, 5.370, or 8.055 × 1012/cm2.

The eBNPs significantly reduced colony-forming capacity in all studied cells during BNCT compared to BPA, verified by cell-survival curves fit to the linear-quadratic model and calculated radiobiological parameters, though the effect of both compounds differed depending on the cell line. The results of our study warrant further tumor targeting-oriented modifications of synthesized nanoparticles and subsequent in vivo BNCT experiments.
Here we consider a contribution of Delta(1232) resonance to real photon radiative corrections for elastic $ep$-scattering.

The effect is found to be small for past experiments to study unpolarized cross section as well as for the recent VEPP-3 experiment to investigate two-photon exchange effects by precision measurement of $e^\pm p$-scattering cross sections ratio.

The effect is found to be small for past experiments to study unpolarized cross section as well as for the recent VEPP-3 experiment to investigate two-photon exchange effects by precision measurement of $e^\pm p$-scattering cross sections ratio.
The device represents Φ-shaped configuration providing a strongly unsteady flow due to periodic oscillations based on the Coanda effect.

Large-eddy simulations are performed to investigate the internal dynamics of a fluidic oscillator over a range of Reynolds numbers Re d = 3000 – 30000. Computational results for a mesh convergence study are presented.

The conducted analysis of statistical characteristics of the flow has shown that the flow velocity in the feedback channels increases with an increase in the Reynolds number. The obtained results, such as the frequency of vibrations and the depth of the jet, perfectly match the experimental data.
ACTIVITY is a database on DNA/RNA site sequences with known activity magnitudes, measurement systems, sequence-activity relationships under fixed experimental conditions and procedures to adapt these relationships from one measurement system to another. This database deposits information on DNA/RNA affinities to proteins and cell nuclear extracts, cutting efficiencies, gene transcription activity, mRNA translation efficiencies, mutability and other biological activities of natural sites occurring within promoters, mRNA leaders, and other regulatory regions in pro- and eukaryotic genomes, their mutant forms and synthetic analogues. Since activity magnitudes are heavily system-dependent, the current version of ACTIVITY is supplemented by three novel sub-databases: (i) SYSTEM, measurement systems; (ii) KNOWLEDGE, sequence-activity relationships under fixed experimental conditions; and (iii) CROSS_TEST, procedures adapting a relationship from one measurement system to another. These databases are useful in molecular biology, pharmacogenetics, metabolic engineering, drug design and biotechnology. The databases can be queried using SRS and are available through the Web, http://wwwmgs.bionet.nsc.ru/systems/Activity/.
Recent works by the authors have shown the high efficiency of using thin liquid films, moving under the action of gas in a flat mini-channel, for removing high heat fluxes.

In the present work, we carefully study the total heat losses in such a system. Total heat losses are divided into two portions: heat losses from the heating coil to the atmosphere and heat spreadings from the heater to the substrate.

The relative values of the total heat losses prior to the crisis are decreasing with increasing critical heat flux and do not exceed approximately 20% for the critical heat flux between 500 and 900 W/cm 2 .
In modern linguistics there are two main approaches to studying metaphors: semantic (where metaphor is regarded as a linguistic phenomenon) and cognitive, where it is interpreted as a certain way of constructing the reality.

The methodological basis of our research is the theory of metaphorical modeling, which is a synthesis of structural, semantic and cognitive approaches. This article represents a comparative analysis of military metaphors (which are archetypal for political communication) used in the speeches of four presidents of Russia and France of the early 21st century – D. A. Medvedev, N. Sarkozy, V. V. Putin and F. Hollande, and based on the corpora of texts that are examples of political discourse monologues (inaugural, congratulatory, welcoming speeches, etc.). In this study, military metaphors are nominations in which there are signs of military action in the form of opposition to an «enemy» and the use of weapons. The analysis took into account substantive and verbal structural metaphors realizing the conceptual model «Russian / French reality – the ongoing war»; the study also considered extralinguistic factors that influenced the creation of political texts. Text selection took into consideration the degree of importance and relevance of the domestic and foreign policy issues covered in them.

The analysis showed that the frequency of military metaphors usage is not identical not only in the speech of different politicians, but also in the discourse of different societies, and demonstrated individual and national specificity of the military metaphors functioning in the political leaders discourse, which was directly related to the topical "agenda" for a country. Thus, it turned out that the French presidents resort to «militant» (in metaphorical terms) discourse more than the two Russian heads of state; the greatest frequency of military metaphors is demonstrated in F. Hollande’s speeches.
Intensive evaporation of a thin liquid film, moving in a flat micro-/minichannel under the action of gas flow is very promising for the use in cooling systems of modern semiconductor devices with localized heat sources of high intensity. In this work, using the high-speed visualization, the effect of the formation of dry spots on heat transfer in a locally heated liquid film shear-driven in a channel was investigated. It was found that the maximum intensity of heat removal from the heater is achieved in the mode, when the film flow continuity is broken. During the experiment the total area of dry spots increases with increasing heat flux and heater temperature, but when the heater reaches a certain temperature (≈100°C), the total area begins to decrease. However, the length of contact line increases with increasing heat flux and reaches a maximum in the pre-crisis regime. Intensive evaporation in the region of the contact line may explain the achievement of high heat fluxes in the shear-driven liquid film.
We present a measurement of the total branching fraction of the flavor-changing neutral-current process B->Xsl+l-, along with partial branching fractions in bins of dilepton and hadronic system (Xs) mass, using a sample of 471x10^6 Upsilon(4S)->BBbar events recorded with the BaBar detector at the PEP-II e+e- collider. B mesons are reconstructed by combining a dilepton pair, either e+e- or mu+mu-, with 10 different Xs final states containing exactly one charged or neutral kaon, two or fewer charged pions, and at most one pi0. Using a sum over these exclusive modes as the basis for extrapolation to the fully inclusive rate, we measure a lepton-flavor-averaged inclusive branching fraction BF(B->Xsl+l-) = (6.73 +0.70-0.64[stat] +0.34-0.25[exp syst] +/- 0.50[model syst])x10^-6 for m(l+l-)^2>0.1 GeV^2/c^4. Restricting our analysis exclusively to final states from which a decaying B meson's flavor can be inferred, we additionally report measurements of the direct CP asymmetry ACP in bins of dilepton mass; over the full dilepton mass range, we find ACP=0.04 +/- 0.11 +/- 0.01$ for a lepton-flavor-averaged sample.
In this work, we propose a theory describing generation of electromagnetic waves in a thin beam-plasma system with a characteristic transverse size comparable with the radiation wavelength.

Such a theory can be useful for the description of the processes responsible for EM emission in beam-plasma experiments at the GOL-3 multi mirror trap.
Despite the existing advances in the diagnosis and treatment of breast cancer (BC), the search for markers associated with the clinicopathological features of BC is still in demand. MiRNAs (miRs) have potential as markers, since a change in the miRNA expression profile accompanies the initiation and progression of malignant diseases. The receptors for estrogen, androgen, and progesterone (ER, AR, and PR) play an important role in breast carcinogenesis. Therefore, to search for miRNAs that may function as markers in BC, using bioinformatic analysis and the literature data, we selected 13 miRNAs whose promoter regions contain binding sites for ER or AR, or putative binding sites for ER, AR, and PR. We quantified their expression in MCF-7 cells treated with estradiol, progesterone, or testosterone. The levels of miRNAs sensitive to one or more of these hormones were quantified in BC samples (n = 196). We discovered that high expression levels of miR-190b in breast tumor tissue indicate a positive ER status, and miR-423 and miR-200b levels differ between patients with and without HER2 amplification. The miR-193b, -423, -190a, -324, and -200b levels were associated with tumor size or lymph node status in BC patients, but the presence of these associations depended on the status and expression level of ER, PR, HER2, and Ki-67. We also found that miR-21 expression depends on HER2 expression in ER- and/or PR-positive BC. The levels of miRNA were significantly different between HER2 0 and HER2 1+ tumors (p = 0.027), and between HER2 0 and HER2 2+, 3+ tumors (p = 0.005).
We introduce a new model of spatial random multiple access systems with a non-standard departure policy: all arriving messages are distributed uniformly on a finite sphere in the space, and when a successful transmission of a single message occurs, the transmitted message leaves the system together with all its neighbours within a ball of a given radius centred at the message's location. We consider three classes of protocols: centralised protocols and decentralised protocols with either ternary or binary feedback; and analyse their stability. Further, we discuss some asymptotic properties of stable protocols.
The review of the seismicity in Altai and Sayan region for 2014 is presented. The stationary network of seismic stations included 48 stations. Compared to 2013, seven new seismic stations were added in the region. Additionally 3 local temporary networks including 39 temporary seismic stations operated in the region. 8828 earthquakes were recorded with the total seismic energy of 4.6•1012 J. A brief description of the seismicity in the Chui-Kurai zone of the Altai Mountains is given.
Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing deaminases play the prominent role in the etiology of these mutations.

To gain insight into the enigmatic mechanisms of localized hypermutagenesis that lead to cluster formation, we analyzed the mutational single nucleotide variations (SNV) data obtained by whole-genome sequencing of drug-resistant mutants induced in yeast diploids by AID/APOBEC deaminase and base analog 6-HAP. Deaminase from sea lamprey, PmCDA1, induced robust clusters, while 6-HAP induced a few weak ones. We found that PmCDA1, AID, and APOBEC1 deaminases preferentially mutate the beginning of the actively transcribed genes. Inactivation of transcription initiation factor Sub1 strongly reduced deaminase-induced can1 mutation frequency, but, surprisingly, did not decrease the total SNV load in genomes. However, the SNVs in the genomes of the sub1 clones were re-distributed, and the effect of mutation clustering in the regions of transcription initiation was even more pronounced.

At the same time, the mutation density in the protein-coding regions was reduced, resulting in the decrease of phenotypically detected mutants. We propose that the induction of clustered mutations by deaminases involves: a) the exposure of ssDNA strands during transcription and loss of protection of ssDNA due to the depletion of ssDNA-binding proteins, such as Sub1, and b) attainment of conditions favorable for APOBEC action in subpopulation of cells, leading to enzymatic deamination within the currently expressed genes. This model is applicable to both the initial and the later stages of oncogenic transformation and explains variations in the distribution of mutations and kataegis events in different tumor cells.
To establish associations of the frequency of detection of clusters and components of the metabolic syndrome (MS) with the prevalence of depression in open male population of moderately urbanized Siberian city.

Cross-sectional epidemiological survey included 1000 individuals formed from the election list of males in one of the Tyumen administrative districts. The response rate was 85,0%. MS was assessed using the International Diabetes Federation (IDF) criteria. A self-administered WHO MONICA-psychosocial questionnaire was used to assess the levels of depression. Statistical analysis was conducted using a package of software program for medical data IBM SPSS Statistics 21.0.

The strategies for MS prevention in men of moderately urbanized city should contain measures to optimize nutrition regarding psychosocial determinants. This is due not only to the wide prevalence of overweight and obesity in Tyumen population but also to dyslipidemia associated with these factors.
The difference in the crystal structure and growth kinetics of microtubes formed from l- and d-enantiomers of diphenylalanine dipeptide is investigated both experimentally and theoretically by computer simulation. The microtubes of l- and d-enantiomers grown simultaneously and under identical experimental conditions possess different crystallographic space groups, have essential difference in sizes, and demonstrate different growth kinetics. Computer simulation by molecular mechanics methods revealed a fundamental difference in the interaction between structural units of microtubes of different chiralities. A model describing chirality-dependent growth of microtubes is proposed.
Aim. To estimate the prevalence of type 2 diabetes mellitus (DM2) and MODY diabetes as well as the prevalence of metabolic syndrome (MS) components for these types of diabetes in the young population of the city of Novosibirsk.

Materials and methods. In 2013-2017 years a population survey was conducted of a random representative sample of the population of 25-45 years of both sexes, residents of one of the typical districts of Novosibirsk. WHO criteria (1999-2013) were used for the diagnosis of diabetes: fasting blood glucose ≥7.0 mmol / l after an 8-hour fasting. Also group with DM2 included persons with a fasting blood glucose level
Respondents (N = 2,837) answered a series of questions regarding how they are dealing with the COVID-19 situation, and MSTAT-II questionnaire.

It was found that the emotional background is dominated by such emotions as fear, irritation, anxiety and sadness. Tolerance of uncertainty turned out to be negatively associated with all negative emotions, which allows us to consider it as a resource that reduces negative experience in the current situation. Data was also obtained regarding the relationship between the characteristics of the COVID-19 pandemic experience with the age and gender of the respondents.
Heparan sulfate (HS) proteoglycans are key components of cell microenvironment and fine structure of their polysaccharide HS chains plays an important role in cell-cell interactions, adhesion, migration and signaling. It is formed on non-template basis, so, structure and functional activity of HS biosynthetic machinery is crucial for correct HS biosynthesis and post-synthetic modification.

To reveal cancer-related changes in transcriptional pattern of HS biosynthetic system, the expression of HS metabolism-involved genes (EXT1/2, NDST1/2, GLCE, 3OST1/HS3ST1, SULF1/2, HPSE) in human normal (fibroblasts, PNT2) and cancer (MCF7, LNCaP, PC3, DU145, H157, H647, A549, U2020, U87, HT116, KRC/Y) cell lines and breast, prostate, colon tumors was studied. Real-time RT-PCR and Western-blot analyses revealed specific transcriptional patterns and expression levels of HS biosynthetic system both in different cell lines in vitro and cancers in vivo.

Balance between transcriptional activities of elongation- and post-synthetic modification- involved genes was suggested as most informative parameter for HS biosynthetic machinery characterization. Normal human fibroblasts showed elongation-oriented HS biosynthesis, while PNT2 prostate epithelial cells had modification-oriented one. However, cancer epithelial cells demonstrated common tendency to acquire fibroblast-like elongation-oriented mode of HS biosynthetic system. Surprisingly, aggressive metastatic cancer cells (U2020, DU145, KRC/Y) retained modification-oriented HS biosynthesis similar to normal PNT2 cells, possibly enabling the cells to keep like-to-normal cell surface glycosylation pattern to escape antimetastatic control. The obtained results show the cell type-specific changes of HS-biosynthetic machinery in cancer cells in vitro and tissue-specific changes in different cancers in vivo, supporting a close involvement of HS biosynthetic system in carcinogenesis.
The publication presents materials from the excavations of 6 burial mounds belonging to four separate Early Iron Age burial grounds. The investigations were carried out in the Askizsky District of the Republic of Khakassia as part of rescue works in the construction site of the second railway track at the “Chartykovsky - Kamyshta” section. Most of the burials were looted in antiquity. Inlet burials related to Tesinskaya archaeological culture were made in the barrow of an isolated mound of Sagayskaya protoka 5. In the course of the railway construction in the mid-20th century, the earthen barrows and underground stone structures were destroyed (burial site Sagayskaya protoka 1). Nevertheless, some burials have survived intact. This made it possible to establish the details of the funeral rituals and to correlate the archaeological sites with the Podgorny and Saragash stages of the Tagar culture. The Podgorny burials (VII-VI centuries BC) are characterized by arrangement of individual graves. The dead people were placed in stone boxes set in ground pits, accompanied by meat food and grave goods. In the surviving graves, bronze knives, a handle metal stap, mirrors, awls, beads, pendants made of animal teeth and the claw of a bird ofprey were found. The vessels are standard in shape and ornament. Rare finds include miniature combs (less than 2 cm long) decorated with solar symbols. The Saragash stage is represented by grave 4 in the Sagayskaya protoka 5 barrow containing the burials of 9 adults. The burial is tentatively dated to the V-IV centuries BC.
A measurement of the CP asymmetry in B0 -> K*0 mu+ mu- decays is presented, based on 1.0fb-1 of pp collision data recorded by the LHCb experiment during 2011. The measurement is performed in six bins of invariant mass squared of the mu+ mu- pair, excluding the J/psi and psi(2S) resonance regions. Production and detection asymmetries are removed using the B0 -> J/Psi K*0 decay as a control mode. The integrated CP asymmetry is found to be -0.072 +- 0.040 (stat.) +- 0.005 (syst.), consistent with the Standard Model.