Hengzongshu/ArticleAgent huggingface dataset:
The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.
Anthracycline antibiotics are an important group of widely used and highly effective antitumor drugs.

The article presents a clinical case demonstrating the long-term consequences of high-dose polychemotherapy.

The cardiotoxicity of anthracyclines included in the polychemotherapy regimens results in the development of cardiovascular diseases both in the early and late rehabilitation period with the onset of heart failure and coronary artery disease.
The article presents bioethics as a field of social practices containing adaptation of new moral and social norms. The regulatory function of bioethics ensures this process and leads to institutionalization. The traditional position has been criticized. It reduces the institutions of bioethics to ethical committees. Social institutions are explained in an ideational way as a system of norms and values. Ethoses are shown as primary social structures in the development of institutions. The solution of dilemmas is illustrated by the example of transplantology.
The first general estimate in the functional CLT (i.e. in the Invariance Principle) was obtained by A. Borovkov in 1973 in terms of the Lyapunov fractions of order not greater than three.

Here we present explicit numerical bounds for the constants in Borovkov's estimate.

In addition, we have found similar but more precise estimates in terms of truncated Lyapunov fractions.
The first measurement that relates semileptonic and hadronic decay rates of the B+c meson is performed using proton-proton collision data corresponding to 1.0 fb−1 of integrated luminosity collected with the LHCb detector.

The measured value of the ratio of branching fractions, B(B+c→J/ψπ+)/B(B+c→J/ψμ+νμ)=0.0469±0.0028(stat)±0.0046(syst), is at the lower end of available theoretical predictions.

Received 8 July 2014DOI:https://doi.org/10.1103/PhysRevD.90.032009This article is available under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.© 2014 CERN, for the LHCb Collaboration
Large-eddy simulations of the swirling annular jet flow are performed in a model of a combustion chamber at two different flow regimes with and without the central jet at Re = 5000. The mesh convergence study provides well-described time-averaged statistics even for a coarse mesh, while small-scale features are only resolved after a proper refinement.

The central jet is shown to significantly modify the recirculation bubble and partially suppress the precessing vortex core.
Background. Agonistic behavior is necessary for formation of dominant-subordinate relationship and for maintenance of social hierarchy in animal communities. However? there are few reports about the genetic features of agonistic behavior development in animals living in stable social groups.

The aim of the present study was to investigate the ontogeny of agonistic behavior in male mice of different genotype and social status under stable social hierarchy conditions. Materials and methods. We studied the age dynamics of offensive attacks, the vertical defensive postures and the 'runaway' behavior in male mice of inbred strains PT and CBA/Lac housed in genetically heterogeneous pairs during puberty (from 38 to 70 days of life).

Results. Dominant-subordinate relationships were stable in 80 % of pairs during the experiment. During the period of stable social hierarchy we observed a transient increase in the number of offensive attacks at the end of puberty in dominants of the strain CBA/Lac but not in PT. Conclusion. In conclusion, the study revealed a significant influence of social rank and genotype on the development of patterns of social behavior in laboratory male mice during puberty.
В статье предложен подход к построению исследовательской среды для интеграции информационных ресурсов определенной области знаний и поддержки научных исследований. Особенностью подхода является комбинация в рамках единой информационной системы, основанных на онтологиях средств представления, систематизации и аннотирования интегрированных в систему ресурсов, а также ориентация на совместную работу специалистов над созданием размеченного корпуса. В статье приведен пример применения предложенного подхода для разработки информационной системы. The paper presents an approach to the development of a research environment, facilitating an integration of information resources dedicated to a certain scientific domain and supporting scientific research. The main feature of the approach is combining an ontology-based tools for presenting and annotating scientific information resources within a single information system. The development of the information system is aimed towards the joint work of researchers on the creating annotated corpora of resources. The paper provides an example of the proposed approach being put into practice when developing an information system.
Due to the presence of a ripple on the output of various power sources, and mechanical vibrations the VEPP-3 wiggler beam is subject to certain perturbations (oscillations). Such disturbances can distort the results of precise experiments. At the same time the existing stabilization system of the synchrotron radiation (SR) beam works with a large averaging times and almost not sensitive to these disturbances. The differential high-speed detector based on pin-photodiodes and electronic processing circuits (that provide filtering and correlated double sampling of the signals) was developed for observation of the SR beam vertical oscillations. Detector is supplemented by electromechanical system for automatically adjustment of the sensor in beam center and allows to record slow displacement with a resolution of up to 0.2 microns. It is expected that in the future this system can be connected to fast correctors of VEPP-3 storage ring for feedback suppression of the beam oscillations.
Comprehensive structural optimization of chimeric antigen receptors (CARs) is the key to their successful performance both in vitro and in vivo.

In order to compare various CAR designs in an unified format, we took advantage of a lentiviral platform, where all CAR modules can be easily shuffled and tested for functionality. This platform was used to delineate the effects of various spacer regions on the function of a PSCA-specific CAR in the context of a human NK cell line, YT.

We show that three CAR designs (IgG1-, CD8a-, and spacerless) perform similarly in vitro regardless of the length of the spacer region.
Experiments were carried out on recombinant B6.CBA-D13Mit76C (B6-M76C) and B6.CBA-D13Mit76B (B6-M76B) mouse lines created by transferring a 102.73-118.83 Mbp fragment of chromosome 13, containing the 5-HT1A receptor gene, from CBA or C57BL/6 strains to a C57BL/6 genetic background, correspondingly. We have recently shown different levels of 5-HT1A receptor functionality in these mouse lines. The administration of BDNF (300 ng/mouse, i.c.v.) increased the levels of exploratory activity and intermale aggression only in B6-M76B mice, without affecting depressive-like behavior in both lines. In B6-M76B mice the behavioral alterations were accompanied by a decrease in the 5-HT2A receptor functional activity and the augmentation of levels of serotonin and its main metabolite, 5-HIAA (5-hydroxyindoleacetic acid), in the midbrain. Moreover, the levels of dopamine and its main metabolites, HVA (homovanillic acid) and DOPAC (3,4-dihydroxyphenylacetic acid), were also elevated in the striatum of B6-M76B mice after BDNF treatment. In B6-M76C mice, central BDNF administration led only to a reduction in the functional activity of the 5-HT1A receptor and a rise in DOPAC levels in the midbrain. The obtained data suggest the importance of the 102.73-118.83 Mbp fragment of mouse chromosome 13, which contains the 5-HT1A receptor gene, for BDNF-induced alterations in behavior and the brain monoamine system.
The market of pharmaceutically valuable proteins is the fastest growing segment of the economy. Most biopharmaceuticals have been obtained in mammalian and microorganism cells, but both systems have a number of disadvantages. Plant cells combine the advantages of the eukaryotic system of protein production and the simplicity and cheapness of the bacterial, and the use of plants for the production of recombinant proteins is an economically important and promising direction. The advantage of plant systems is the lower cost of cell cultivation. They are free from unwanted components, such as bacterial endotoxins, hyperglycosylated proteins produced by yeast, animal and human pathogens in cell cultures of transgenic animals. In addition, plants are higher eukaryotes, and therefore fullvalue folding and the formation of multimeric protein complexes occur in their cells, as well as a significant portion of post­translational modifications similar to those in mammalian cells. The currently developed plant expression systems for recombinant proteins are extremely diverse and number more than 100 different technologies based on different plant species, gene transfer methods, expression strategies, methods for the subsequent extraction of the target protein, etc. This is nuclear and plastid transformation, transient and stable expression during transformation using agrobacterial transport, bombardment or electroporation, cultivation of whole terrestrial or aquatic plants, plant tissues or suspension cell cultures as expression systems. The review examines the current state of research in the use of plant expression systems for the production of recombinant proteins for pharmaceuticals. The emphasis was placed on the advantages of plant cell cultures in comparison with other expression systems. Specific examples discuss promising plant systems for the production of recombinant proteins, such as transplastomic plants, moss and aquatic plant cultures, as well as suspension cultures of cells of higher plants. The current state of the market for recombinant proteins obtained using plant expression systems is considered. The prospects of creating plant (“edible”) vaccines based on genetically modified plants are discussed.
A subgroup [Formula: see text] of a group [Formula: see text] is said to be pronormal in [Formula: see text] if [Formula: see text] and [Formula: see text] are conjugate in [Formula: see text] for each [Formula: see text]. Some problems in Finite Group Theory, Combinatorics and Permutation Group Theory were solved in terms of pronormality, therefore, the question of pronormality of a given subgroup in a given group is of interest. Subgroups of odd index in finite groups satisfy a native necessary condition of pronormality. In this paper, we continue investigations on pronormality of subgroups of odd index and consider the pronormality question for subgroups of odd index in some direct products of finite groups. In particular, in this paper, we prove that the subgroups of odd index are pronormal in the direct product [Formula: see text] of finite simple symplectic groups over fields of odd characteristics if and only if the subgroups of odd index are pronormal in each direct factor of [Formula: see text]. Moreover, deciding the pronormality of a given subgroup of odd index in the direct product of simple symplectic groups over fields of odd characteristics is reducible to deciding the pronormality of some subgroup [Formula: see text] of odd index in a subgroup of [Formula: see text], where each [Formula: see text] acts naturally on [Formula: see text], such that [Formula: see text] projects onto [Formula: see text]. Thus, in this paper, we obtain a criterion of pronormality of a subgroup [Formula: see text] of odd index in a subgroup of [Formula: see text], where each [Formula: see text] is a prime and each [Formula: see text] acts naturally on [Formula: see text], such that [Formula: see text] projects onto [Formula: see text].
The biodiversity of bacterial communities along the Yenisei River at section c. 1800 km was studied using next-generation sequencing of 16S rRNA genes and common biodiversity indices. Overall, 3022 unique operational taxonomic units were identified. Actinobacteria and Proteobacteria were the dominant phyla at all sampling sites. The highest alpha-diversity values were found in the middle section of the studied river. The beta-diversity of bacterial assemblages in the river was related to the surrounding landscape (biome): three distinctly different bacterial assemblages occurred in sections of the river, situated in mountain taiga, plain taiga and in a region of permafrost, covered by forest-tundra and tundra. Tributaries arising from these different landscapes likely contributed substantially to the variations of Yenisei bacterial communities. In contrast to a prediction of the river continuum concept, the proportion of photoautotrophic Cyanobacteria in bacterial assemblages did not increase downstream, but peaked at the middle section.
Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having an IC50 value of 0.64 µM. When tested in the A-549 lung adenocarcinoma cell line, no or very limited cytotoxic effect was observed for the ligands. However, in conjunction with topotecan, a well-established Topoisomerase 1 (Top1) poison in clinical use against cancer, derivative 46a was very cytotoxic at 5 µM concentration, displaying strong synergism. This effect was only seen for 46a (IC50—3.3 µM) albeit some other ligands had better IC50 values. Molecular modelling into the catalytic site of Tdp1 predicted plausible binding mode of 46a, effectively blocking access to the catalytic site.
The isogenic lines of wheat (Tritkum aestivum L. var. Novosibirskaja 67) carrying reduced height and leaf pubescence character

were evaluated for their ability to regenerate plants from immature embryo-derived calli using protocols based on six different media. The percentage of calli capable of plant regeneration was recorded. The effect of media on the formation of regenerative calli in the various isogenic lines is demonstrated.

Significant differences were observed between the initial variety and the isogenic lines with the Rht genes on several media. The distinctive difference of Novosibirskaja 67 and sib of ANK-7A not carrying the marker character with ANK-7A line isogenic for leaf pubescence was revealed on two media. It is suggested that the leaf pubescence gene of ANK-7A or a gene closely linked to it are likely to play an important role in the control of plant regeneration in vitro. The fact that there is the medium where ANK.-7A produced calli regenerating plants while Novosibirskaja 67 and K-26011 (donor of leaf pubescence for ANK-7A) are completely incapable of plant regeneration confirms that the expression of these genes is influenced by the genomic background.
Urinary albumin excretion (UAE) is widely used in clinical practice as indicator of diabetic kidney disease. According to the classical concept of the natural course of diabetic nephropathy, an increase in UAE usually precedes a decline in renal function. Meanwhile, a growing body of evidences indicates a high prevalence of normoalbuminuric chronic kidney disease (NA-CKD) in diabetic subjects, especially among patients with type 2 diabetes.

The search for alternative diagnostic markers for detecting of diabetic kidney disease in the absence of albuminuria, is of practical importance. The evaluations of the markers of tubular damage and interstitial fibrosis, as well as proteomic approaches, are considered as perspective diagnostic and prognostic options in NA-CKD.

An increase in NA-CKD prevalence can be results of improved glucose, blood pressure, and lipid control, widespread use of renin-angiotensin system blockers, and smoking cessation. It was shown that NA-CKD is more prevalent among women and is associated with arterial hypertension and coronary artery disease. The renal structure in subjects with NA-CKD is more heterogeneous when compared to patients with increased albuminuria, wherein interstitial changes and arteriolosclerosis could be the principal morphological findings, while signs of glomerulopathy may be absent. The prognostic value of NA-CKD needs to be clarified. It was shown that NA-CKD increases the risk of myocardial infarction, stroke and cardiovascular death in patients with diabetes. The study of pathogenesis, pathology, clinical course of NA-CKD in diabetic patients, as well as the development of more specific diagnostic and treatment options is a challenge for future research.
Large device variation is a fundamental challenge for resistive random access memory (RRAM) array circuit.

Improved device-to-device distributions of set and reset voltages in a SiNx RRAM device is realized via arsenic ion (As+) implantation. Besides, the As+-implanted SiNx RRAM device exhibits much tighter cycle-to-cycle distribution than the nonimplanted device. The As+-implanted SiNx device further exhibits excellent performance, which shows high stability and a large 1.73 × 103 resistance window at 85 °C retention for 104 s, and a large 103 resistance window after 105 cycles of the pulsed endurance test. The current–voltage characteristics of high- and low-resistance states were both analyzed as space-charge-limited conduction mechanism. From the simulated defect distribution in the SiNx layer, a microscopic model was established, and the formation and rupture of defect-conductive paths were proposed for the resistance switching behavior.

Therefore, the reason for such high device performance can be attributed to the sufficient defects created by As+ implantation that leads to low forming and operation power.
Carboxylic acids conjugated with 4,5-dimethoxy-2-nitrobenzyl photoremovable protecting group are well known and widely used for biological studies.

In this paper, we study the photolysis of likewise 'caged' acetic, caprylic and arachidonic acids. Following further UV irradiation, a product with fluorescence at longer wavelength was formed (470 nm excitation / ~500–600 nm emission). Illumination of droplets by UV rapidly induces orange fluorescence excited by 488 nm light.

While it may be used to monitor the 'uncaging', these fluorescent products may interfere with widespread dyes such as fluorescein in biomedical experiments. These self-organized lipophilic structures with fluorescence turn-on capability may be of interest for biomedical and other application. We have identified and hypothesized some compounds which may be responsible for the observed fluorescense.
Background: According to current data, an effective Ebola virus vaccine should induce both humoral and T-cell immunity. In this work, we focused our efforts on methods for delivering artificial T-cell immunogen in the form of a DNA vaccine, using generation 4 polyamidoamine dendrimers (PAMAM G4) and a polyglucin:spermidine conjugate (PG).

Methods: Optimal conditions were selected for obtaining complexes of previously developed DNA vaccines with cationic polymers. The sizes, mobility and surface charge of the complexes with PG and PAMAM 4G have been determined. The immunogenicity of the obtained vaccine constructs was investigated in BALB/c mice.

Results: It was shown that packaging of DNA vaccine constructs both in the PG envelope and the PAMAM 4G envelope results in an increase in their immunogenicity as compared with the group of mice immunized with the of vector plasmid pcDNA3.1 (a negative control). The highest T-cell responses were shown in mice immunized with complexes of DNA vaccines with PG and these responses significantly exceeded those in the groups of animals immunized with both the combination of naked DNAs and the combination DNAs coated with PAMAM 4G. In the group of animals immunized with complexes of the DNA vaccines with PAMAM 4G, no statistical differences were found in the ability to induce T-cell responses, as compared with the group of mice immunized with the combination of naked DNAs. Conclusions: The PG conjugate can be considered as a promising and safe means to deliver DNA-based vaccines. The use of PAMAM requires further optimization.
We discuss various experiments on e+e− annihilation into hadrons relevant to the problem of the muon anomalous magnetic moment. They include a status of the ISR measurements of the e+e− → π+π− as well as studies of numerous hadronic final states in experiments with the CMD-3 and SND detectors at the VEPP-2000 e+e− collider.
We present the results of a search for the rare decays $B\to h\nu\overline{\nu}$, where $h$ stands for $K^+,\:K^0_{\mathrm{S}},\:K^{\ast +},\:K^{\ast 0},\:\pi^+,\:\pi^0,\:\rho^+$ and $\rho^{0}$.

The results are obtained with $772\times10^{6}$ $B\overline{B}$ pairs collected with the Belle detector at the KEKB $e^+ e^-$ collider. We reconstruct one $B$ meson in a semileptonic decay and require a single $h$ meson but nothing else on the signal side.

We observe no significant signal and set upper limits on the branching fractions. The limits set on the $B\to K^0_{\mathrm{S}}\nu\overline{\nu}$, $B^0\to K^{*0}\nu\overline{\nu}$, $B\to \pi^+\nu\overline{\nu}$, $B^0\to\pi^0\nu\overline{\nu}$, $B^+\to\rho^+\nu\overline{\nu}$, and $B^0\to\rho^0\nu\overline{\nu}$ channels are the world's most stringent.
Experimental evidence of the plasma flow suppression by the helical magnetic mirror is presented. Reported experiments were done during the first plasma campaign in the SMOLA helical mirror device at self-consistent floating potentials of all in-vessel electrodes and at minimal magnetic fields suitable for confinement regime. The experimental results are consistent with two main theory predictions for the helical mirror confinement: a reduction of the axial plasma flow and the inward particle pinch. The helical mirror technology can dramatically improve fusion reactor prospects of open magnetic configurations.