Hengzongshu/ArticleAgent huggingface dataset:
Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates. Thanks to myelin, the speed of electrical-signal conduction increases several hundred-fold because myelin serves as a kind of electrical insulator of nerve f ibers and allows for quick saltatory conduction of action potentials through Ranvier nodes, which are devoid of myelin. Given that different parts of the central nervous system are myelinated at different stages of development and most regions contain both myelinated and unmyelinated axons, it is obvious that very precise mechanisms must exist to control the myelination of individual axons. As they go through the stages of specification and differentiation – from multipotent neuronal cells in the ventricular zone of the neural tube to mature myelinating oligodendrocytes as well as during migration along blood vessels to their destination – cells undergo dramatic changes in the pattern of gene expression. These changes require precisely spatially and temporally coordinated interactions of various transcription factors and epigenetic events that determine the regulatory landscape of chromatin. Chromatin remodeling substantially affects transcriptional activity of genes. The main component of chromatin is the nucleosome, which, in addition to the structural function, performs a regulatory one and serves as a general repressor of genes. Changes in the type, position, and local density of nucleosomes require the action of specialized ATP-dependent chromatin-remodeling complexes, which use the energy of ATP hydrolysis for their activity. Mutations in the genes encoding proteins of the remodeling complexes are often accompanied by serious disorders at early stages of embryogenesis and are frequently identified in various cancers. According to the domain arrangement of the ATP-hydrolyzing subunit, most of the identified ATP-dependent chromatin-remodeling complexes are classified into four subfamilies: SWI/SNF, CHD, INO80/SWR, and ISWI. In this review, we discuss the roles of these subunits of the different subfamilies at different stages of oligodendrogenesis.
Biologists more and more have to deal with objects with non-numeric descriptions: texts (e.g. genetic sequences or even whole genomes), graphs, images, etc. There even could be no variables or descriptions at all when variability of objects is defined by similarity matrix. It is also possible to have too many variables (e.g. a magnitude of millions is reachable in mass spectrometry or genome research). In this case it is necessary to switch to object similarity matrices which drastically reduces dimensionality to hundreds or thousands.

We developed a simple and convenient package JACOBI4, which allows researchers without programming experience to automate multidimensional statistical analysis. Package and methods implemented in it can be useful in studies of both medical (gene expression for various diseases) and biological (regularities of molecular sequence variability) data. The package can be used directly, taking already developed scripts and editing them to fit own needs.

Package JACOBI4 is freely available at [w1]. There are also articles available in which JACOBI4 is used to process real world data, as well as supplemental files containing JACOBI4 scripts and data for them. It goes without saying that the use of JACOBI4 is in no way limited to these examples.
We use $(121\ifmmode\pm\else\textpm\fi{}1)$ million $\mathrm{\ensuremath{\Upsilon}}(3S)$ and $(98\ifmmode\pm\else\textpm\fi{}1)$ million $\mathrm{\ensuremath{\Upsilon}}(2S)$ mesons recorded by the BABAR detector at the PEP-II ${e}^{+}{e}^{\ensuremath{-}}$ collider at SLAC to perform a study of radiative transitions involving the ${\ensuremath{\chi}}_{b\mathrm{J}}(1P,2P)$ states in exclusive decays with ${\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}\ensuremath{\gamma}\ensuremath{\gamma}$ final states.

We reconstruct twelve channels in four cascades using two complementary methods. In the first we identify both signal photon candidates in the electromagnetic calorimeter (EMC), employ a calorimeter timing-based technique to reduce backgrounds, and determine branching-ratio products and fine mass splittings. In the second method, we identify one photon candidate in the EMC and one which has converted into an ${e}^{+}{e}^{\ensuremath{-}}$ pair due to interaction with detector material, and we measure absolute product branching fractions.

These results include the best observational significance yet for the ${\ensuremath{\chi}}_{b0}(2P)\ensuremath{\rightarrow}\ensuremath{\gamma}\mathrm{\ensuremath{\Upsilon}}(2S)$ and ${\ensuremath{\chi}}_{b0}(1P)\ensuremath{\rightarrow}\ensuremath{\gamma}\mathrm{\ensuremath{\Upsilon}}(1S)$ transitions. This method is particularly useful for measuring $\mathrm{\ensuremath{\Upsilon}}(3S)\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\chi}}_{b1,2}(1P)$ decays. Additionally, we provide the most up-to-date derived branching fractions, matrix elements and mass splittings for ${\ensuremath{\chi}}_{b}$ transitions in the bottomonium system. Using a new technique, we also measure the two lowest-order spin-dependent coefficients in the nonrelativistic QCD Hamiltonian.
During a 2016-2017 survey conducted in Isfahan, Lorestan, Markazi, North Khorasan, Razavi Khorasan, South Khorasan and Tehran provinces located in the Central and North-Eastern Iran, about 1000 specimens of Dolichopodidae were collected and identified.

Eight dolichopodid species [Dolichopus jaxarticus Stackelberg, 1927, Hydrophorus viridis (Meigen, 1824), Medetera diadema (Linnaeus, 1767), M. lamprostoma Loew, 1871, M. roghii Rampini et Canzoneri, 1979, Tachytrechus kowarzi Mik, 1864, Tachytrechus sogdianus Loew, 1871, and Thinophilus flavipalpis (Zetterstedt, 1843)] are recorded for the first time in Iran. Dolichopus subimmaculatus Kazerani, Pollet, Khaghaninia, 2017, is placed in synonymy with Dolichopus perversus Loew, 1871 (syn. nov.). Lectotype is designated for D. perversus.
The Internet anonymity for a long time made it difficult for journalists to use the content presented in it. Now, thanks to the convergence of the "virtual" personality and the "real" one, this problem has been mitigated. Journalists begin to perceive social networks as sources of information, and they start to interpret what is published in them as reliable data or public statements. This research shows the extent of penetration of social networks information to the media, characterizes structural-functional features of this recent journalism tool. This work shows how often, when and for which purposes Media uses the social networks and how does this situation influences the articles. The continuous selection from RIA Novosti, Life.ru and Lenta.ru (683 articles) allowed us to examine features of representation of information from social networks. It was found that journalists use social media materials to confirm some fact or position of a person, as an information guide, they borrow there photos or videos, and, analyzing the comments, reproduce the "opinion of the audience". In general, it is shown that social networks have already secured the place of information providers for the media. The media began to trust this information, learned how to work with it, to process it for certain genres. There are even special software tools that allow Internet media to integrate very organically posts from social networks into their pages with publications when creating a site. The identical virtual personality of a real person, created now in social media, increasingly brings communication within the network closer to communication in real life, which expands the professional journalistic toolkit.
Heterostructures with InAs/AlAs quantum dots are grown on GaAs/Si hybrid substrates. The experimentally observed low-temperature (5–80 K) photoluminescence spectra of InAs/AlAs/GaAs/Si heterostructures exhibit bands defined by excitonic recombination in quantum dots and a wetting layer, i.e., a thin quantum well lying at the base of the array of quantum dots. Temperature quenching of the photoluminescence of quantum dots occurs due to the direct trapping of charge carriers at defects localized in the AlAs matrix, in the vicinity of the quantum dots.
Measured values of the tensor analyzing power T20 for the coherent photoproduction of a π0-meson on a deuteron are analyzed in the region of large momentum transfer. The incident photons of the photoproduction reaction γd→dπ0 are the quasi-real virtual photons arising from the electron scattering in the electroproduction reaction ed→edπ0.

The kinematic region of large momentum transfer is of particular interest, as it corresponds to small inter-nucleon distances in the deuteron. In this case, the amplitude of the process under study is noticeably sensitive to both the deuteron wave function at small inter-nucleon distances and the various model uncertainties arising from the description of the process for large momentum transfer.

A comparison shows a significant discrepancy between the experimental data and the predictions from a number of theoretical models.
To identify associations of mtDNA polymorphisms with sudden cardiac death.

DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U, T and J) were determined using restriction fragment length polymorphism analysis. In addition, we performed a comparative analysis using previously published data on mtDNA polymorphisms in the West Siberian population.

The distribution of mtDNA haplogroups in the patients who died from sudden cardiac death was similar as in the general population: 40% for haplogroup H, 23% for haplogroup U, 12% for haplogroup T and 6.5% for haplogroup J. We found no significant differences regarding the frequency of mtDNA haplogroups in individuals who died from sudden cardiac death and the population level. We discovered no associations of H, U, T, and J mtDNA haplogroups with sudden cardiac death. These results indicate the necessity of a detailed analysis of mitochondrial genome to determine mtDNA variants associated with sudden cardiac death.
The co-crystallisation of [NiEn3](NO3)2 (En = ethylenediamine) with Na2MoO4 and Na2WO4 from a water solution results in the formation of [NiEn3](MoO4)0.5(WO4)0.5 co-crystals. According to the X-ray diffraction analysis of eight single crystals, the parameters of the hexagonal unit cell (space group P-31c, Z = 2) vary in the following intervals: a = 9.2332(3)-9.2566(6); c = 9.9512(12)-9.9753(7) Å with the Mo/W ratio changing from 0.513(3)/0.487(3) to 0.078(4)/0.895(9). The thermal decomposition of [NiEn3](MoO4)0.5(WO4)0.5 individual crystals obtained by co-crystallisation was performed in He and H2 atmospheres. The ex situ X-ray study of thermal decomposition products shows the formation of nanocrystalline refractory alloys and carbide composites containing ternary Ni-Mo-W phases. The formation of carbon-nitride phases at certain stages of heating up to 1000 °C were shown.
Purpose. The article considers three sabers stored in the Akmola Regional Museum of Local History (inv. No. ГИК 2322/1, ARMLH, Kokshetau, Kazakhstan), National Museum of the Republic of Kazakhstan (inv. No. KRUM 802, NMRK, Nur-Sultan, Kazakhstan) and a private collection. The saber from NMRK was found in a destroyed mound in the Shet District, Karaganda Region (Central Kazakhstan). Results. Total lengths of these sabers are: 90.5, 73.0 and 91 cm (including the blade length – 82.2, 66.3 and 82.2. cm, widths in the area of the ricasso are 3.5, 3.4 and 3.5 cm). All three single-edged blades under consideration have a more or less strong curve. The tip of the saber from the private collection has a rib and double edge clips with long pronounced iron ‘tongues’ welded on to the ricasso of the blade. In two cases the ‘tongues’ are decorated with sharp-angled spikes. A rivet attaching the ‘cheeks’ of the hilt is inserted into the hole of the tang blade that is bent sideward (the saber from the private collection has an S-shaped rivet head). The guard has a characteristic ‘boat-shaped’ design. Based on the typological analysis, it was identified that the samples under consideration differ from traditional sabers of the Turkic nomads of Kazakhstan during the Kimak and Kipchak periods (10th – 12th Centuries). Their closest analogues were found on the territory of Southern Siberia and date back to the 13th – 14th Centuries. It is highly possible that the appearance of sabers of this type on the territory of Northern and Central Kazakhstan were associated with the events of the Mongol invasion in the 13th Century and the inclusion of Eastern Dasht-I Kipchak into the Mongol Empire. Conclusion. It seems that the sabers were forged by masters in Southern Siberia and were then brought to Northern and Central Kazakhstan by the Chingizid troops. The small number of long-bladed weapons of the 13th – 14th centuries found on the territory of Kazakhstan determines high scientific value of the considered sabers.
We present a laboratory study on the instability of internal wave attractors in a trapezoidal fluid domain filled with uniformly stratified fluid. Energy is injected into the system via standing-wave-type motion of a vertical wall. Attractors are found to be destroyed by parametric subharmonic instability via a triadic resonance which is shown to provide a very efficient energy pathway from long to short length scales. This Letter provides an explanation of why attractors may be difficult or impossible to observe in natural systems subject to large amplitude forcing.
Epoxidation of propylene into propylene oxide (PO) in the gas phase is a highly challenging reaction. Cu-based catalysts have been active for this reaction, but the state of Cu as an active species is still debatable.

In this paper, we report the propylene epoxidation activity of solution combustion synthesized Cu/CeO2 catalysts with the CO + O2 mixture at low temperatures (50–100 °C) peaking at ∼80 °C. The highest PO yield was obtained with 20–25% Cu loading in CeO2. In contrast, the reaction over the catalyst containing nonreducible support such as Cu/SiO2 occurred above 170 °C. Detailed structural characterization indicated two types of Cu species such as Cu2+ partly (∼3%) dissolved in CeO2 forming a CuxCe1–xO2−δ phase and the remaining amount formed highly dispersed CuO as a separate phase.

Thus, the highest activity relates to the optimum presence of CuO along with Ce1–xCuxO2−δ. The reducibility of the Cu species in two phases was significantly shifted toward lower temperatures, indicating strong electronic interaction between the two phases. The substituted Cu2+ was reduced first, and then, the bulk CuO reduction was initiated. In situ spectroscopic studies showed Cu+ formation from Cu2+ over Cu/CeO2 catalysts even at room temperature unlike in CeO2 or CuO + CeO2 physical mixtures, indicating strong electronic interaction between Ce1–xCuxO2−δ and CuO phases on CO adsorption in the Cu/CeO2 catalyst. It is proposed that substituted Cu2+ along with Ce4+ is reduced easily, and then, Ce3+ promotes the reduction of the interfacial CuO phase that might donate active oxygen species for epoxidation reaction.
Extracellular double-stranded DNA participates in various processes in an organism.

Here we report the suppressive effects of fragmented human double-stranded DNA along or in combination with cyclophosphamide on solid and ascites grafts of mouse Krebs-2 tumor cells and DNA preparation on human breast adenocarcinoma cell line MCF-7. Apoptosis and necrosis were assayed by electrophoretic analysis (DNA nucleosomal fragmentation) and by measurements of LDH levels in ascitic fluid, respectively. DNA internalization into MCF-7 was analyzed by flow cytometry and fluorescence microscopy.

Direct cytotoxic activity of double-stranded DNA (along or in combination with cyclophosphamide) on a solid transplant was demonstrated. This resulted in delayed solid tumor proliferation and partial tumor lysis due to necrosis of the tumor and adjacent tissues. In the case of ascites form of tumor, extensive apoptosis and secondary necrosis were observed. Similarly, MCF-7 cells showed induction of massive apoptosis (up to 45%) as a result of treatments with double-stranded DNA preparation. Double-stranded DNA (along or in combination with cyclophosphamide) induces massive apoptosis of Krebs-2 ascite cells and MCF-7 cell line (DNA only). In treated mice it reduces the integrity of gut wall cells and contributes to the development of systemic inflammatory reaction.
The features of the paramagnetic properties of lanthanide (Ln) containing complexes with crown ethers, pivaloyltrifluoracetonato, and EDTA have been studied by 1 H and 19 F NMR techniques.These complexes are of interest due to the prospect of using some of them as sensors for biology and medicine.The temperature dependencies of the lanthanide-induced shifts revealed that Ln complexes might have practical importance for 1 H and 19 F NMR temperature control in solutions.It was shown in vitro (using NMR spectrometers and MRI scanners) that these complexes can serve as special NMR thermo-sensitive contrast reagents.
The Toarcian Oceanic Anoxic Event (T-OAE, c . 182 Ma) represents a major perturbation of the carbon cycle marked by widespread black shale deposition. Consequently, the onset of the T-OAE has been linked to the combined effects of global warming, high productivity, basin restriction and salinity stratification. However, the processes that led to termination of the event remain elusive. Here, we present palynological data from Arctic Siberia (Russia), the Viking Corridor (offshore Norway) and the Yorkshire Coast (UK), all spanning the upper Pliensbachian – upper Toarcian stages. Rather than a ‘dinoflagellate cyst black-out’, as recorded in T-OAE strata of NW Europe, both the Arctic and Viking Corridor records show high abundance and dinoflagellate diversity throughout the T-OAE interval as calibrated by C-isotope records. Significantly, in the Arctic Sea and Viking Corridor, numerous species of the Parvocysta and Phallocysta suites make their first appearance in the lower Toarcian Falciferum Zone much earlier than in Europe, where these key dinoflagellate species appeared suddenly during the Bifrons Zone. Our results indicate migrations of Arctic dinoflagellate species, driven by relative sea-level rise in the Viking Corridor and the establishment of a S-directed circulation from the Arctic Sea into the Tethys Ocean. The results support oceanographic models, but are at odds with some interpretations based on geochemical proxies. The migration of Arctic dinoflagellate species coincides with the end of the T-OAE and marks the arrival of oxygenated, low-salinity Arctic waters, triggering a regime change from persistent euxinia to more dynamic oxygen conditions.
Based on structural and lithological grid models, a three-dimensional numerical dynamic model of the Mesozoic-Cenozoic sedimentary cover of the Gydan source kitchen and adjacent territories was built. The thermal history of sediments was reconstructed. A map of effective deep heat flow was compiled. A good agreement was found between the measured and calculated degrees of catagenetic transformation for Upper Jurassic rocks. The possible types of kerogens from the main Jurassic and Cretaceous source rock sequences were justified. The study also provides assessments of the volumes of hydrocarbon generation from the main source rock sequences, timing of formation of regional seals and possible extent of hydrocarbon accumulation in structural traps.
We report one-step fast synthesis and consolidation of iron aluminide FeAl of high open porosity by pressureless reactive Spark Plasma Sintering (SPS). The starting material of the Fe-40at.%Al composition was a mixture of an iron powder with an average particle diameter of 4 μm and an aluminum powder with an average particle diameter of 6 μm.

The rationale behind the choice of the SPS as a processing technique and fine and comparable sizes of the two reactants for the synthesis of high-open porosity FeAl was realization of fast full chemical conversion of Fe and Al into single-phase FeAl reducing the time available for the compact shrinkage.

According to the XRD phase analysis, single-phase FeAl compacts formed after SPS at 800 and 900°C. These compacts had open porosities of 41 and 46%, respectively. The transverse rupture strength of the compacts sintered at 700-900°C was found to change little with the sintering temperature in the selected range.
Despite the high degree of archaeological and anthropological research of the Tagar culture and its carriers, many directions of study of this Sothern Siberian Iron Age population remain relevant.

This work is devoted to the consideration of the data on the genetic composition of the Tagar culture population, obtained to date by paleogenetic methods. The study of representative mtDNA sample series from chronologically different groups of the Tagar population (N = 79), carried out by the authors of this work, allow us to obtain the first objective view on the composition of its mitochondrial gene pool. The obtained results illustrate well the significance of analysis of representative sample series when performing paleogenetic reconstructions.

The general Tagar population is characterized by the presence in the gene pool of both Western Eurasian (H, HV6, HV*, I, K, T, U2e, U4, U5a, and U*) and Eastern Eurasian (A*, A8, C*, C5, D, G2a, F1b) mtDNA haplogroups. Unlike other populations of southern Siberia of the Scythian time, Western Eurasian variants dominate in the Tagar gene pool. Among the previous populations, the Tagar population demonstrates affinity with the populations of the Minusinsk Basin of the Middle Bronze Age. When compared with the groups of early nomads of Eurasia, the Tagar population shows a similarity in terms of the mtDNA variability with the carriers of other cultures of the Scythian circle, occupying an intermediate position between the geographically distant Scythians of the Northern Black Sea region and the population of the south Siberian cultures, Pazyryk and Aldy-Bel. During the transition from the Podgorny to the Saragashen stages, the Tagar population converges with other groups of early nomads of southern Siberia. In the Tagar gene pool of the Y chromosome, the dominance of variants of the R1a1a haplogroup was revealed. This genetic cluster was first introduced into the Minusinsk Basin by the carriers of the Andronovo (Fedorovo) culture. However, additional in-depth analysis of the Tagar Y chromosome lineages is required to clarify their origin. The paper presents the most promising directions for further research of the Tagar populations using paleogenetic methods.
We report the first observation of the doubly Cabibbo-suppressed decays $D^+ \rightarrow K^+ \eta^{(\prime)}$ using a 791 fb$^{-1}$ data sample collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider.

The ratio of the branching fractions of doubly Cabibbo-suppressed relative to singly Cabibbo-suppressed $D^+ \rightarrow \pi^+ \eta^{(\prime)}$ decays are $\mathcal{B}(D^+ \rightarrow K^+ \eta)/\mathcal{B}(D^+ \rightarrow \pi^+ \eta)$ = (3.06 $\pm$ 0.43 $\pm$ 0.14)% and $\mathcal{B}(D^+ \rightarrow K^+ \eta')/\mathcal{B}(D^+ \rightarrow \pi^+ \eta')$ = (3.77 $\pm$ 0.39 $\pm$ 0.10)%.

From these, we find that the relative final-state phase difference between the tree and annihilation amplitudes in $D^+$ decays, $\delta_{TA}$, is (72 $\pm$ 9)$^\circ$ or (288 $\pm$ 9)$^\circ$. We also report the most precise measurements of CP asymmetries to date: $A_{CP}^{D^+ \rightarrow \pi^+ \eta}$ = (+1.74 $\pm$ 1.13 $\pm$ 0.19)% and $A_{CP}^{D^+ \rightarrow \pi^+ \eta'}$ = ($-$0.12 $\pm$ 1.12 $\pm$ 0.17)%.