Hengzongshu/ArticleAgent huggingface dataset:
Domestication of wild animals alters the aggression towards humans, brain monoamines and coat pigmentation. Our aim is the interplay between aggression, brain monoamines and depigmentation. The Hedlund white mutation in the American mink is an extreme case of depigmentation observed in domesticated animals.

The aggressive (-2.06 ± 0.03) and tame (+3.5 ± 0.1) populations of wild-type dark brown color (standard) minks were bred during 17 successive generations for aggressive or tame reaction towards humans, respectively. The Hedlund mutation was transferred to the aggressive and tame backgrounds to generate aggressive (-1.2 ± 0.1) and tame (+3.0 ± 0.2) Hedlund minks. Four groups of 10 males with equal expression of aggressive (-2) or tame (+5) behavior, standard or with the Hedlund mutation, were selected to study biogenic amines in the brain.

Decreased levels of noradrenaline in the hypothalamus, but increased concentrations of the serotonin metabolite, 5-hydroxyindoleacetic acid and dopamine metabolite, homovanillic acid, in the striatum were measured in the tame compared with the aggressive standard minks. The Hedlund mutation increased noradrenaline level in the hypothalamus and substantia nigra, serotonin level in the substantia nigra and striatum and decreased dopamine concentration in the hypothalamus and striatum. Significant interaction effects were found between the Hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (P < 0.001), dopamine level in the midbrain (P < 0.01) and its metabolism in the striatum (P < 0.05). These results provide the first experimental evidence of the interplay between aggression, brain monoamines and the Hedlund mutation in the American minks.
The phenological synchrony between the emergence of overwintering herbivorous insects and the budding of host plants is considered a crucial factor in the population dynamics of herbivores. However, the mechanisms driving the interactions between the host plant, herbivores, and their pathogens are often obscure.

In the current study, an artificially induced phenological asynchrony was used to investigate how the asynchrony between silver birch Betula pendula and gypsy moth Lymantria dispar affects the immunity of the insect to bacteria, its susceptibility to the entomopathogenic bacteria Bacillus thuringiensis, and the diversity in its midgut microbiota. The lysozyme‐like activity in both the midgut and hemolymph plasma and the nonspecific esterase activity and antimicrobial peptide gene expression in the midgut were studied in both noninfected and B. thuringiensis‐ infected larvae.

Our results provide the first evidence that phenologically asynchronous larvae are less susceptible to B. thuringiensis infection than phenologically synchronous larvae, and our results show that these effects are related to the high basic levels and B. thuringiensis ‐induced levels of lysozyme‐like activities. Moreover, a 16S rRNA analysis revealed that dramatic decreases in the diversity of the larval gut bacterial consortia occurred under the effect of asynchrony. Larvae infected with B. thuringiensis presented decreased microbiota diversity if the larvae were reared synchronously with the host plant but not if they were reared asynchronously. Our study demonstrates the significant effect of phenological asynchrony on innate immunity‐mediated interactions between herbivores and entomopathogenic bacteria and highlights the role of nonpathogenic gut bacteria in these interactions.
We present the essential features of the dissipative parametric instability, in the universal complex Ginzburg- Landau equation. Dissipative parametric instability is excited through a parametric modulation of frequency dependent losses in a zig-zag fashion in the spectral domain. Such damping is introduced respectively for spectral components in the +ΔF and in the -ΔF region in alternating fashion, where F can represent wavenumber or temporal frequency depending on the applications. Such a spectral modulation can destabilize the homogeneous stationary solution of the system leading to growth of spectral sidebands and to the consequent pattern formation: both stable and unstable patterns in one- and in two-dimensional systems can be excited. The dissipative parametric instability provides an useful and interesting tool for the control of pattern formation in nonlinear optical systems with potentially interesting applications in technological applications, like the design of mode- locked lasers emitting pulse trains with tunable repetition rate; but it could also find realizations in nanophotonics circuits or in dissipative polaritonic Bose-Einstein condensates.
The text of the work presents an analysis of some of the world's phenomena in the era of postmodern from a psychological standpoint. A person can feel uncertainty and anxiety due to changes in the postmodern world. Along with reality, there is a virtual version of it, real objects and events are replaced by their signs, or simulacrum. There are catastrophic phenomena at different levels of human life.

Art also undergoes changes, which, on the one hand, reflect the state of reality and the inner world of the person-creator, and on the other hand, they construct the present and the future, influencing the perception of the viewer.

The article raises questions about what is art in current time, what are the characteristics of art perception, and how artworks can affect a person in the postmodern world.
We have used ISR technique to measure the proton magnetic form factor in the energy region from 3.0 to 6.5 GeV and charged kaon form factor in the range from 2.6 to 7.5 GeV.

The proton data clearly indicate that the difference between values of time- and space-like magnetic form factors decreases with increase of energy.

The kaon form factor decreases with energy faster than 1/E2, approaching the asymptotic pQCD predictions.
ВОСТОЧНАЯ СИБИРЬ И ДАЛЬНИЙ ВОСТОК КАК ОСНОВА УСТОЙЧИВОГО РАЗВИТИЯ НЕФТЕГАЗОВОГО КОМПЛЕКСА РОССИИВ статье рассмотрено современное состояние нефтегазового сектора Восточной Сибири и Дальнего Востока
Duration from sowing to flowering is of critical importance for crop adaptation. Breeding for the optimal flowering time is one of the major factors, which confer maximal yields in a given environment. The timing of flowering is modulated primarily by responsiveness to photoperiod and temperature, and there are large differences in sensitivity among genotypes. In most spring wheat cultivars the duration of the vegetative period is strongly influenced by genes controlling photoperiod response.

In this paper we report the photoperiod responses of a set of 'Chinese Spring' substitution and partial deletion lines of homoeologous group 2 chromosomes studied under natural short days. We confirmed the presence of dominant genes Ppd1 and Ppd2 on chromosomes 2D and 2B, respectively, and compared the effects of Ppd1 and Ppd2 for daylength response.

The photoperiodic responses of partial chromosome deletion lines of 'Chinese Spring' allowed us to map Ppd2 physically between breakpoints 0.27 and 0.53 of the short arm of chromosome 2B. This result is consistent with the finding of a possible location of Ppd2 based on molecular marker studies. A dosage effect of the dominant gene Ppd2 was shown.
Here, we proposed a new approach to engineering a photoactivatable CRISPR/Cas9 gene-editing system. The novel nanoCRISPR/Cas9 system is based on the use of auxiliary photocleavable oligodeoxyribonucleotides (PC-DNAs) complementary to crRNA. PC-DNAs contained up to three UV-sensitive linkers made of 1-(2-nitrophenyl)-1,2-ethanediol inside the oligonucleotide chain. Immobilizing PC-DNAs on the surface of carbon nanoparticles through 3'-terminal pyrene residue provided sufficient blocking of crRNA (and corresponding Cas9 activity) before UV irradiation and allows for crRNA release after UV irradiation at 365 nm, which restores Cas9 activity. We optimized the length of blocking photocleavable oligonucleotide, number of linkers, time of irradiation, and the type of carbon nanoparticles. Based on the results, we consider the nanoCRISPR/Cas9 system involving carbon-encapsulated iron nanoparticles the most promising. It provides the greatest difference of functional activity before/after irradiation and can be used in prospective for magnetic field-controlled delivery of CRISPR system into the target cells or tissues and spatiotemporal gene editing induced by UV irradiation.
The aim of this article is systematization of the constraints impeding the intensification of the use of PPP as a mechanism of socio-economic development of Russian regions. Issues of interpretation and definition of PPP, questions of methodical and personnel support of the process of investment projects promotion to implementation on the principles of PPP, a number of organizational and legal aspects were raised. It is proposed to use a game approach to operationalize the process of potential participants of PPP agreements strategies coordination.
Described herein, the first microsatellite linkage map for the American mink consists of 85 microsatellite markers resolved into 17 linkage groups. The map was constructed using 92 F 1 progeny from five sire families created by crossing mink with different colour types. The linkage groups ranged from 0 to 137 cM. These linkage groups were assigned to 12 of the 14 mink autosomes using a somatic cell hybrid panel. The total map covered 690 sex‐averaged Kosambi units with an average marker spacing of 8 cM.

This map will facilitate further genetic mapping of monogenic characters and QTL.
A measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at √s=13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 36.1 fb⁻¹ is presented.

Events with one electron and one muon are selected, corresponding to the decay of the diboson system as WW→e±νμ∓ν. To suppress top-quark background, events containing jets with a transverse momentum exceeding 35 GeV are not included in the measurement phase space.

The fiducial cross-section, six differential distributions and the cross-section as a function of the jet-veto transverse momentum threshold are measured and compared with several theoretical predictions. Constraints on anomalous electroweak gauge boson self-interactions are also presented in the framework of a dimension-six effective field theory.
Possible early diagnostic application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier-transform infrared spectroscopy, Raman spectroscopy) in studies of red blood cells and serum of patients with diffuse liver disease with varying degrees of fibrosis has been evaluated.

Application of combined optical methods was confirmed to significantly improve the performance of sensitivity, specificity, and accuracy index as well as to achieve the reliable results in diagnosis of both severe fibrosis and slight ulterior liver fibrosis.

Identified diagnostic potential of optical methods can be effectively utilized in noninvasive screening evaluation of stages of diffuse liver disease of various geneses.
ПРИЛОЖЕНИЯ К ЕЖЕГОДНИКАМ КРУПНЫХ ЯПОНСКИХ ГАЗЕТ КАК ИСТОЧНИК ДЛЯ ОНОМАСТИЧЕСКИХ ИССЛЕДОВАНИЙСоздание различных ономастических баз данных, каталогов, атласов относятся к актуальным задачам современной науки.В отличие от топонимических исследований, в настоящее время нелегко получить доступ к идеальным базам для исследования антропонимов, поскольку личные имена и личные данные являются приватной информацией
Using a sample of 158 million \Upsilon(2S) events collected with the Belle detector, charmonium and charmonium-like states with even charge parity are searched for in \Upsilon(2S) radiative decays. No significant \chi_{cJ} or \eta_c signal is observed and the following upper limits at 90% confidence level (C.L.) are obtained: BR(\Upsilon(2S)\to \gamma \chi_{c0})< 1.0 \times 10^{-4}, BR(\Upsilon(2S) \to \gamma \chi_{c1})<3.6 \times 10^{-6}, BR(\Upsilon(2S) \to \gamma \chi_{c2})<1.5 \times 10^{-5}, and BR(\Upsilon(2S) \to \gamma \eta_c)< 2.7 \times 10^{-5}. No significant signal of any charmonium-like state is observed, and we obtain the limits \BR(\Upsilon(2S)\to \gamma X(3872))\times\BR(X(3872)\to\pi^+\pi^-J/\psi)< 0.8 \times 10^{-6}, BR(\Upsilon(2S) \to \gamma X(3872))\times BR(X(3872)\to\pi^+\pi^-\pi^0 J/\psi)< 2.4\times 10^{-6}, BR(\Upsilon(2S) \to \gamma X(3915))\times BR(X(3915)\to\omega J/\psi)< 2.8\times 10^{-6}, BR(\Upsilon(2S) \to \gamma Y(4140))\times BR(Y(4140)\to\phi J/\psi)) < 1.2\times 10^{-6}, and BR(\Upsilon(2S) \to \gamma X(4350))\times BR(X(4350)\to\phi J/\psi))< 1.3\times 10^{-6} at 90% C.L.
We study the γ*γ* total cross section in the NLA BFKL approach.

We have extracted the NLO corrections to the photon impact factor from two recent papers of Balitsky and Chirilli and Chirilli and Kovchegov and used them to build several representations of the total cross section, equivalent within the NLA. We have combined these different representations with two among the most common methods for the optimization of a perturbative series, namely PMS and BLM,

and compared their behavior with the energy with the only available experimental data, those from the LEP2 collider.
Human α-lactalbumin (LA) has an important function in mammary cells, activates the caspases involving in apoptosis.LA complex interacts with DNA in tumor cells with histones and impaired the chromatin structure.There are no any data on how LA recognizes DNA and interact with histones and DNA of chromatin.

The approach of stepwise increase in ligand complexity was used for estimation of the relative contribution of every DNA nucleotide unit to its total affinity for human LA.It was shown that the LA DNA-binding site minimal ligands are orthophosphate and all dNMPs and rNMPs (K d =(5.0-43)×10 -5 ).Maximal contribution to the total affinity was observed for three nucleotide units of all (pN) n with a significant decrease in the order 1>2>3, at n=4-6 it was remarkably lower and at n ≥ 6-7 all dependencies of -logK d upon n reached plateaus.Double-stranded (pN) n showed significantly lower affinity comparing with singlestranded ligands.The thermodynamic parameters characterizing the specific contribution of (pN) 1-6 every nucleotide link (ΔG o ) to their total affinity for LA were estimated.The spatial model of LA-DNA complex was calculated.

LA protein sequence has homology with those of five histones (H1-H4) involved in the chromatin nucleus interactions between themselves and their complex with DNA.It is assumed that the homology may be the main reason for the interaction of LA with chromatin DNA, leading to a breakdown in its structure, as well as the proper binding of histones between themselves and with DNA.
The mineral and chemical compositions of ores from the Corrida epithermal Au-Ag deposit (Chukchi Peninsula, Russia) were studied using the optical and scanning electron microscopy with X-ray energy-dispersion microanalysis. The deposit was formed at the time close to the period when the basic volume of acid magmas had been emplaced within the Okhotsk–Chukotka belt (84 to 80 Ma). The Au–Ag mineralization is distinguished with Au-Ag sulphides and selenides (uytenbogaardtite-fischesserite solid solution, Se-acanthite, S-naumannite) and Ag halides of the chlorargyrite-embolite-bromargyrite series. The ores were formed in two stages. Using microthermometric methods, it has been established that the ore-bearing quartz was formed in the medium-temperature environment (340–160 °C) with the participation of low-salt (3.55 to 0.18 wt.% NaCl eq.) hydrotherms, mostly of the NaCl composition with magnesium, iron and low-density СО2. According to our results of thermodynamic modeling at temperatures from 300 to 25 °C and data on mineral metasomatic alterations of the host rocks, the Au-Ag-S-Se-Cl-Br mineralization was formed at decreasing temperature and fugacity of sulphur (logƒS2 from −6 to −27), selenium (logƒSe2 from −14 to −35), and oxygen (logƒО2 from −36 to −62), with near-neutral solutions replaced by acid solutions. Analysis of the obtained data shows that the Corrida refers to the group of the LS-type epithermal deposits. This deposit is a new example of epithermal deposits with significant quantities of Au–Ag chalcogenides (acanthite, uytenbogaardtite, fischesserite, naumannite and others).
Polyethylene was irradiated with intensive electron beam with different doses.

Structure changes after irradiation ex situ and in situ during heating up to its melting point were studied using synchrotron radiation X-Ray diffraction and thermal analysis.
A half-century after the discovery of the superconductor-insulator transition (SIT), one of the fundamental predictions of the theory, the charge Berezinskii-Kosterlitz-Thouless (BKT) transition that is expected to occur at the insulating side of the SIT, has remained unobserved. The charge BKT transition is a phenomenon dual to the vortex BKT transition, which is at the heart of the very existence of two-dimensional superconductivity as a zero-resistance state appearing at finite temperatures. The dual picture points to the possibility of the existence of a superinsulating state endowed with zero conductance at finite temperature.

Here, we report the observation of the charge BKT transition on the insulating side of the SIT, identified by the critical behavior of the resistance.

We find that the critical temperature of the charge BKT transition depends on the magnetic field exhibiting first the fast growth and then passing through the maximum at fields much less than the upper critical field. Finally, we ascertain the effects of the finite electrostatic screening length and its divergence at the magnetic field-tuned approach to the superconductor-insulator transition.
Retrotransposons comprise a substantial fraction of eukaryotic genomes reaching the highest proportions in plants. Therefore, identification and annotation of retrotransposons is an important task in studying regulation and evolution of plant genomes. A majority of computational tools for mining transposable elements (TEs) are designed for subsequent genome repeat masking, often leaving aside the element lineage classification and its protein domain composition. Additionally, studies focused on diversity and evolution of a particular group of retrotransposons often require substantial customization efforts from researchers to adapt existing software to their needs.

Here, we developed a computational pipeline to mine sequences of protein-coding retrotransposons based on the sequences of their conserved protein domains - DARTS. Using the most abundant group of TEs in plants - long terminal repeat (LTR) retrotransposons (LTR-RTs), we show that DARTS has radically higher sensitivity of LTR-RTs identification compared to a widely accepted LTRharvest tool. DARTS can be easily customized for specific user needs.

As a result, DARTS returns a set of structurally annotated nucleotide and amino acid sequences which can be readily used in subsequent comparative and phylogenetic analyses. DARTS should facilitate researchers interested in discovery and in-detail analysis of diversity and evolution of retrotransposons, LTR-RTs, and other protein-coding TEs.
This paper describes our system for SemEval-2021 Task 5 on Toxic Spans Detection. We developed ensemble models using BERT-based neural architectures and post-processing to combine tokens into spans. We evaluated several pre-trained language models using various ensemble techniques for toxic span identification and achieved sizable improvements over our baseline fine-tuned BERT models. Finally, our system obtained a F1-score of 67.55% on test data.
MOTIVATION: A reliable recognition of transcription factor binding sites is essential for analysis of regulatory genomic sequences. The experimental data make evident an important role of DNA conformational features for site functioning. However, Internet-available tools for revealing conformational and physicochemical DNA features significant for the site functioning and subsequent use of these features for site recognition have not been developed up to now.

RESULTS: We suggest an approach for revealing significant conformational and physicochemical properties of functional sites implemented in the database B-DNA-VIDEO. This database is designed to study the sets of various transcription factor binding sites, providing evidence that transcription factor binding sites are characterized by specific sets of significant conformational and physicochemical DNA properties. For a fixed site, by using the B-DNA features selected for this site recognition, the C-program recognizing this site may be generated, control tested and stored in the database B-DNA-VIDEO. Each B-DNA-VIDEO entry links to the Web-applet recognizing the site, whose significant B-DNA features are stored in this entry as the 'site recognition programs'.

The pairwise linked entry-applet pairs are compiled within the B-DNA-VIDEO system, which is simultaneously the database and the program tools package applicable immediately for recognizing the sites stored in the database. Indeed, this is the novelty. Hence, B-DNA-VIDEO is the Web resource of both 'searching for static data' and 'active computation' type, that is why it was called an 'activated database'.
In the paper, we present the Budker Institute long term plans for laying the plasma physics database for an advanced fuel fusion reactor based on the axisymmetric linear magnetic trap. The general approach to development of the reactor utilizes the idea that confinement of a plasma with the highest pressure can be obtained in a linear device with multi-mirror end sections attached at both ends to suppress the axial plasma losses. To develop the required database a stepwise approach is applied, which suggests construction of the several experimental devices with progressively increasing plasma parameters, which incorporate the different constituents of the approach. Ultimately, after successfully proving the ideas in the experiments, a prototype of the reactor will be constructed in the Budker Institute.
Coherent vortex structures are fascinating physical objects that are widespread in nature: from large scale atmospheric phenomena, such as tornadoes and the Great Red Spot of Jupiter to microscopic size topological defects in quantum physics and optics. Unlike classical vortex dynamics in fluids, optical vortices feature new interesting properties. For instance, novel discrete optical vortices can be generated in photonic lattices, leading to new physics. In nonlinear optical media, vortices can be treated as solitons with nontrivial characteristics currently studied under the emerging field of topological photonics. Parallel to theoretical advances, new areas of the engineering applications based on light vortices have emerged. Examples include the possibility of carrying information coded in the vortex orbital angular momentum, understood as a spatial-division-multiplexing scheme, to the creation of optical tweezers for efficient manipulation of small objects. This report presents an overview highlighting some of the recent advances in the field of optical vortices with special attention on discrete vortex systems and related numerical methods for modeling propagation in multi-core fibers.