Hengzongshu/ArticleAgent huggingface dataset:
The paper is focused on the analysis of deterioration of strength properties during cyclic deformation of the titanium alloy VT6, which is widely used in numerous engineering applications.

A set of experimental data is obtained, regarding stress-controlled cyclic loadings with variable R-values; the influence of the mean stress on the irreversible processes is estimated. The impact of a previous loading history on ratcheting and dissipation-induced heating is clarified.

The use of the obtained experimental data for creation and calibration of constitutive models is discussed.
Exosomes are crucial players in cell-to-cell communication and are involved in tumorigenesis. There are two fractions of blood circulating exosomes: free and cell-surface-associated.

Here, we compared the effect of total blood exosomes (contain plasma exosomes and blood cell-surface-associated exosomes) and plasma exosomes from breast cancer patients (BCPs, n = 43) and healthy females (HFs, n = 35) on crucial steps of tumor progression. Exosomes were isolated by ultrafiltration, followed by ultracentrifugation, and characterized by cryo-electron microscopy (cryo-EM), nanoparticle tracking analysis, and flow cytometry.

Both cell-free and blood cell-surface-associated exosomes are involved in the crucial stages of carcinogenesis: the initiation of EMT and the stimulation of proliferation, cell migration, and angiogenesis. Thus, for the estimation of the diagnostic/prognostic significance of circulating exosomes in the blood of cancer patients more correctly, the total blood exosomes, which consist of plasma exosomes and blood cell-surface-associated exosomes should be used.
Foreign investment is the driving force behind the development of the Russian oil and gas complex and the economy as a whole. This was the case until 2014; the current situation has changed somewhat: the inflow of foreign investment in the Russian energy sector is complicated not only by the imposed sanctions, but also by the main obstacle - instability of world energy prices. The current price conjuncture, as well as the situation with supply and demand, is pushing foreign investors to reduce investment proposals.

The article analyzes the dynamics, species and sectoral structure of annual flows of foreign investment in the Russian economy, which allows to identify the main trends in attracting foreign capital in the past few years.

In the Russian economy, at the moment, the most attractive areas for foreign investors are mining, manufacturing, wholesale and retail trade. These economic activities account for more than 60% of the total foreign investment.
In the present study, water is considered as a dynamic network between molecules at distances not exceeding 3.2 angstroms. The instantaneous configurations obtained by using the molecular dynamics method have been sequentially analyzed, the mutual orientation of each molecule with its neighboring molecules has been studied and the interaction energy of each pair of neighbor molecules has been calculated. The majority of mutual orientation angles between molecules lie in the interval [10, 30] degrees. It has been shown that more than 85% of the molecular pairs in each instantaneous configuration form H-bonds and the H-bond network includes all water molecules in the temperature range 233-293 K. The number of H-bonds fluctuates near the mean value and increases with decreasing temperature, and the energy of the vast majority of such bonds is much higher than the thermal energy. The interaction energy of 80% of the H-bonding molecular pairs lies in the interval [-7; -4] kcal/mol. The interaction energy of pairs that do not satisfy the H-bond angle criterion lies in the interval [-5; 4] kcal/mol, and the number of such bonds does not exceed 15% and decreases with decreasing temperature. For the first time it was found that in each instantaneous configuration the H-bond network contains built-in nanometric structural heterogeneities formed by shorter H-bonds. The fraction of molecules involved in the structural heterogeneities increases from 40% to 60% with a temperature decrease from 293 K to 233 K. These heterogeneities have a finite lifetime, but are constantly present in the water. The number of large heterogeneities (containing more than 20 molecules) increases with decreasing temperature, and the number of small structural heterogeneities (less than 20) decreases.
Because the C-ON bond homolysis rate constant k d is an essential parameter of alkoxyamine reactivity, it is especially important to tune k d without a major alteration of the structure of the molecule. Recently, several approaches have become known, e.g., protonation of functional groups and formation of metal complexes. In this paper, coordination reactions of [Zn(hfac)2(H2O)2] with a series of new SG1-based alkoxyamines affording complexes with different structures are presented. The k d values of the complexed forms of the alkoxyamines were compared to those of free and protonated ones to reveal the contribution of the electron-withdrawing property and structure stabilization. Together with previously published data, this work provides clues to the design of alkoxyamines that can be effectively activated upon coordination with metal ions. Furthermore, our results provide insight into the mechanism underlying the influence of complexation on the reactivity of alkoxyamines. This led us to describe different types of coordination: intramolecular in nitroxyl fragment, intramolecular in alkyl fragment, intramolecular between alkyl and nitroxyl fragment, and intermolecular one. All of them exhibit different trends which are dramatically altered by changes in conformation.
The article is devoted to the characteristics of environmental investments in the Russian Federation, which are divided into two types: the first investments are aimed at the development and implementation of environmentally friendly production technologies; the second investments are directed to the commissioning of environmental protection and nature-cleaning fixed assets. Investments of the second type are considered in more detail. The data of modern statistics show the reduction of organizations with special costs, associated with investments in the construction of environmental facilities. The dynamics of “green” investments, their structure by directions and sources of financing are analyzed. Economic methods to stimulate environmental investments of enterprises and increase, targeted government spending on the environment, are proposed. As a result, we can consider that transition is needed from the residual principle of financing environmental protection to a directed increase in targeted government spending.
This work reports for the first time on study of a single-frequency Nd:YVO4 laser with intra-cavity frequency doubling

in which quasi-continuous frequency tuning over an ultra-broad range is implemented with two intra-cavity locked etalons and automatic stitching between ranges of smooth scanning of the laser's output frequency

The proposed and demonstrated method allowed to continuously tune the output frequency of the studied 1.5-W Nd:YVO4/LBO laser over a record-breaking broad range of 240 GHz at 532 nm
To study the dependence of the effectiveness of antihypertensive therapy on the polymorphic variants of candidate genes of the RAAS (ACE, AGT, AGTR1) in patients with hypertension (АH) of the population of Mountain Shoria.

In the conditions of the expeditions from 2013 to 2017, the population of Mountain Shoria was surveyed. Included 1409 people 18 years and older. Blood pressure monitoring was carried out as a result of office measurement, according to the standard recommendations of National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). As a result of the survey, patients with AH were identified for further observation (597 people) who need medical antihypertensive treatment. Repeat screening was conducted in a year. The criterion for inclusion in prospective observation of patients with hypertension was: regular intake of prescribed medication. 253 respondents were surveyed: indigenous (156 people) and non-indigenous (97 people) nationality. All patients underwent a standard examination, including the collection of complaints and anamnesis, an assessment of objective status, laboratory and instrumental studies. Polymorphisms of genes ACE (I/D, rs 4340), AGT (c.803T C, rs699), AGTR1 (A1166C, rs5186) were tested using polymerase chain reaction.

Dynamic observation of patients with hypertension found that in the cohort of Shors the target level of blood pressure reached the owners of heterozygous I/D and minor D/D genotypes of the ACE gene, carriers of T/C and C/C genotypes of the AGT gene and the homozygous genotype A/A of the AGTR1 gene. In the non-indigenous nationality cohort, only carriers of the D/D genotype of the ACE gene. National differences were identified with respect to the sensitivity of the pharmacological response to treatment, which once again proves the important role of taking into account the ethnic factor in the choice of drug.
The results are based on a data sample that contains $772\ifmmode\times\else\texttimes\fi{}1{0}^{6}\text{ }\text{ }B\overline{B}$ pairs collected at the $\mathrm{\ensuremath{\Upsilon}}(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider.

We report a study of the charmless hadronic decay of the charged $B$ meson to the three-body final state ${K}^{+}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$.

The measured inclusive branching fraction and direct $CP$ asymmetry are $(5.38\ifmmode\pm\else\textpm\fi{}0.40\ifmmode\pm\else\textpm\fi{}0.35)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}$ and $-0.170\ifmmode\pm\else\textpm\fi{}0.073\ifmmode\pm\else\textpm\fi{}\phantom{\rule{0ex}{0ex}}0.017$, respectively. The ${K}^{+}{K}^{\ensuremath{-}}$ invariant mass distribution of the signal candidates shows an excess in the region below $1.5\text{ }\text{ }\mathrm{GeV}/{c}^{2}$, which is consistent with the previous studies from BABAR and LHCb. In addition, strong evidence of a large direct $CP$ asymmetry is found in the low ${K}^{+}{K}^{\ensuremath{-}}$ invariant-mass region.
Cytomixis is a poorly studied process of nuclear migration between plant cells. It is so far unknown what drives cytomixis and what is the functional state of the chromatin migrating between cells. Using immunostaining, we have analyzed the distribution of posttranslational histone modifications (methylation, acetylation, and phosphorylation) that reflect the functional state of chromatin in the tobacco microsporocytes involved in cytomixis. We demonstrate that the chromatin in the cytomictic cells does not differ from the chromatin in intact microsporocytes according to all 14 analyzed histone modification types. We have also for the first time demonstrated that the migrating chromatin contains normal structures of the synaptonemal complex (SC) and lacks any signs of apoptosis. As has been shown, the chromatin migrating between cells in cytomixis is neither selectively heterochromatized nor degraded both before its migration to another cell and after it enters a recipient cell as micronuclei. We also showed that cytomictic chromatin contains marks typical for transcriptionally active chromatin as well as heterochromatin. Moreover, marks typical for chromosome condensation, SC formation and key proteins required for the formation of bivalents were also detected at migrated chromatin.
The paper aims to make а fair supplement to the concept of "metaphysics of relations" (bу М. Esfeld) with а coгrect coгresponding interpretation of the dispositional natшe of characteristics within Е. J. Lowe's ontology. А reasoning from science to philosophy leads М. Esfeld to the conclusion that "quantum entanglement understood in terms of non-separability of states speaks for the metaphysics of relations that denies the presence of intrinsic characteristics of the related systems". The same naturalistic argument provides rationale for the Е. J. Lowe's claim that "the attribution of а characteristics to а given kind could bе metaphysically contingent" for "the laws of nature can bе exactly what they are revealed to us, only because there are no other substantial kinds that could instantiate objects". As а heuristics for the intentional interpretation ofE. J. Lowe's dispositionalism we deal with the requirements of "time-relativeness" and "relevance to causality" from W. Malzkorn's list of criteria of satisfactory representation of dispositions.
A Gram-reaction-positive, motile, thermophilic spore-forming strain, G1w1(T), was isolated from a hot spring of the Valley of Geysers, Kamchatka (Russia).

Based on data from the present polyphasic taxonomic study, including phylogenetic analysis of 16S rRNA and spo0A gene sequences,

the strain is considered to represent a novel species of the genus Geobacillus, for which the name Geobacillus icigianus sp. nov. is proposed. The type strain is G1w1(T) ( = VKM B-2853(T) = DSM 28325(T)).
This paper deals with the acoustic features of the Surgut Khanty consonants. The research is based on the data gathered during fieldwork in Kogalym town (2018) and the Ugut village (2019). The audio samples are provided by three native speakers of the Tromjegan, Malyi Yugan, and Bolshoi Yugan idioms. The total size of the sample database numbers more than six thousand isolated consonant pronouncements.

The data for the research was obtained using oscillographic and spectrographic methods, formant locus analysis, spectral moment analysis. The analysis was performed via Praat and Emu-SDMS software. For the fricative, lateral-fricative consonants, affricates spectral moment analysis has been carried out. The spectral moments technique gives an opportunity to represent complex noise data as a relatively small set of numbers that can be processed statistically. The formant analysis is used to estimate consonant resonant frequencies.

Oscillograghy and spectrography methods reveal that voiceless fricative phonemes may be voiced in intervocalic distribution. It is common for the sonants to become devoiced in the final and preconsonantal positions. Moreover, due to devoicing, different phonemes may acquire low-obstruent and obstruent consonant features. According to the data on spectral moments, four types of noise have been defined: high-frequency low-dispersion noise resembling /s/, medium-frequency low-dispersion noise resembling /ʃ/, /tʃ/, /cc/, low-frequency medium-dispersed noise for phonemes /ɫ/, / /, low-frequency dispersed noise for phonemes /w/, /γ/. As shown by the formant locus analysis, the smallest values of the second formant locus are associated with the labial and velar phonemes. Larger values are associated with the coronal phonemes. The largest ones are specific to the palatal phonemes. At the same time, the acoustic features make it possible to stably distinguish the nasal /n/ - /ɲ/, wherein the opposition of the middle and fron lingual articulations is observed only in some speakers' recordings for the pairs /ɫ/ - / /, /tʃ/ - /cc/.
Two new two-dimensional zinc(II) coordination polymers containing 2,5-thiophenedicarboxylate and bitopic ligands bis(1,2,4-triazol-1-yl)methane (btrm) or 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) were synthesized. Synthesized compounds were characterized by IR spectroscopy, elemental analysis, powder X-ray diffraction, and thermal analysis. Crystal structures of coordination polymers were determined and their structural peculiarities are discussed. The differences in structural features, thermal behavior, and luminescent properties are discussed.
The width of the f 1 (1285) → e+e + e - decay is calculated in the vector meson dominance model. The result depends on the relative phase between two coupling constants describing f 1 → ρ 0 γ decay. The width Γ( f 1 → e+e + e - ) is estimated to be ≃ 0:07 - 0:19 eV. Direct f 1 production in e+e + e - collisions is discussed, and the e+e + e - → f 1 → a 0 π → ηππ cross section is calculated. Charge asymmetry in the e+e + e - → ηπ + π - reaction due to interference between e+e + e - → f 1 and e+e + e - → ηρ 0 amplitudes is studied.
Background Perioperative cardiac arrest is a rare complication with an incidence of around 1 in 1400 cases, but it carries a high burden of mortality reaching up to 70% at 30 days. Despite its specificities, guidelines for treatment of perioperative cardiac arrest are lacking. Gathering the available literature may improve quality of care and outcome of patients. Methods The PERIOPCA Task Force identified major clinical questions about the management of perioperative cardiac arrest and framed them into the therapy population [P], intervention [I], comparator [C], and outcome [O] (PICO) format. Systematic searches of PubMed, Embase, and the Cochrane Library for articles published until September 2020 were performed. Consensus-based treatment recommendations were created using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. The strength of consensus among the Task Force members about the recommendations was assessed through a modified Delphi consensus process. Results Twenty-two PICO questions were addressed, and the recommendations were validated in two Delphi rounds. A summary of evidence for each outcome is reported and accompanied by an overall assessment of the evidence to guide healthcare providers. Conclusions The main limitations of our work lie in the scarcity of good quality evidence on this topic. Still, these recommendations provide a basis for decision making, as well as a guide for future research on perioperative cardiac arrest.
Design of materials for solid oxide fuel cells cathodes and oxygen separation membranes and studying their oxygen transport characteristics are important problems of modern hydrogen energy. In the current work, fundamentals of such materials design based on characterization of their oxygen mobility by oxygen isotope exchange with C 18 O 2 and 18 O 2 in flow and closed reactors for samples of Ruddlesden – Popper-type oxides Ln 2-x Ca x NiO 4+δ , perovskite-fluorite nanocomposites PrNi 0.5 Co 0.5 O 3-δ – Ce 0.9 Y 0.1 O 2-δ , etc. are presented. Fast oxygen transport was demonstrated for PNC – YDC ( DO ~10 -8 cm 2 /s at 700°C) nanocomposites due to domination of the fast diffusion channel involving oxygen of the fluorite phase with incorporated Pr cations and developed perovskite-fluorite interfaces. For LnCNO materials a high oxygen mobility ( DO ~10 -7 cm 2 /s at 700°C) provided by the cooperative mechanism of its migration was demonstrated. Depending on Ca dopant content and Ln cation nature, in some cases 1–2 additional channels of the slow diffusion appear due to decreasing the interstitial oxygen content and increasing the energy barrier for oxygen jumps due to cationic size effect. Optimized by the chemical composition and nanodomain structure materials of these types demonstrated a high performance as SOFC cathodes and functional layers in asymmetric supported oxygen separation membranes.
Ceftriaxone (CEF) is a safe and multipotent antimicrobial agent that possesses neuroprotective properties. Earlier, we revealed the restoration of cognitive function in OXYS rats with signs of Alzheimer's disease (AD)-like pathology by CEF along with its modulating the expression of genes related to the system of amyloid beta (Aβ) metabolism in the brain. The aim of this study was to determine the effects of CEF on behavior, Aβ deposition, and associated neuroinflammation using another model of an early AD-like pathology induced by Aβ. Mice were injected bilaterally i.c.v. with Aβ fragment 25-35 to produce the AD model, while the CEF treatment (100 mg/kg/day, i.p., 36 days) started the next day after the surgery. The open field test, T-maze, Barnes test, IntelliCage, and passive avoidance test were used for behavioral phenotyping. Neuronal density, amyloid accumulation, and the expression of neuroinflammatory markers were measured in the frontal cortex and hippocampus. CEF exhibited beneficial effects on some cognitive features impaired by Aβ neurotoxicity including complete restoration of the fear-induced memory and learning in the passive avoidance test and improved place learning in the IntelliCage. CEF significantly attenuated amyloid deposition and neuroinflammatory response. Thus, CEF could be positioned as a potent multipurpose drug as it simultaneously targets proteostasis network and neuroinflammation, as well as glutamate excitotoxicity, oxidative pathways, and neurotrophic function as reported earlier. Together with previous reports on the positive effects of CEF in AD models, the results confirm the potential of CEF as a promising treatment against cognitive decline from the early stages of AD progression.
By the modified ISSR-amplification method the comparison of the structural organization of enzyme loci in the initial common wheat cultivars and their genotrophs induced with epimutagens: plant niacin acid and niacin acid and its derivatives produced from β-picoline fraction of coal-tar pitch (niacin acid nitrile, isocinchomeronic and benzoic acids) was carried out. It is shown that niacin acid influence causes in genotrophs specific band appearance in PCR-profiles obtained on the DNA of enzyme loci. All these before mentioned epimutagens induced in limits of each genotroph differently directed changes in number and intensity of bands of PCR-profiles.
Equilibrium problems for a 2D elastic bodies with thin Euler-Bernoulli and Timoshenko elastic inclusions are considered. It is assumed that inclusions have a joint point, and a junction problem for these inclusions is analyzed. Existence of solutions is proved, and different equivalent formulations of problems are discussed. In particular, junction conditions at the joint point are found. A delamination of the elastic inclusions is also assumed. In this case, inequality type boundary conditions are imposed at the crack faces to prevent a mutual penetration between crack faces. A convergence to infinity of a rigidity parameter of the elastic inclusions is investigated. Limit problems are analyzed.
The work is devoted to numerical simulation of the dynamics of nonlinear periodic waves on the surface of freely flowing liquid film realized with the use of the previously discovered symmetry of model equations.

The calculation results have been presented for the dynamics of amplitudes of significant harmonics and for the wave surface evolution.

They prove to be in good agreement with previously calculated steady-state traveling solutions obtained on the full and the reduced bases. In addition, the work has identified intervals of wavenumbers in which the evolution of perturbations with small initial amplitude leads to a wave signal periodically changing in time rather than to the steady-state traveling solution.
Intensively evaporating liquid films, moving under the friction of a co-current gas flow in a mini-channel (shear-driven liquid films), are promising for the use in cooling systems of modern semiconductor devices with high local heat release.

In this work, the effect of various parameters, such as the liquid and gas flow rates and channel height, on the critical heat flux in the locally heated shear-driven water film has been studied. A record value of the critical heat flux of 1200 W/cm2 has been achieved in experiments. Heat leaks to the substrate and heat losses to the atmosphere in total do not exceed 25% for the heat flux above 400 W/cm2.

Comparison of the critical heat fluxes for the shear-driven liquid film and for flow boiling in a minichannel shows that the critical heat flux is an order of magnitude higher for the shear-driven liquid film. This confirms the prospect of using shear-driven liquid films in the modern high-efficient cooling systems.