Hengzongshu/ArticleAgent huggingface dataset:
Bacteria of the Wolbachia genus are maternally inherited symbionts of Nematoda and numerous Arthropoda hosts. There are approximately 20 lineages of Wolbachia, which are called supergroups, and they are designated alphabetically. Wolbachia strains of the supergroups A and B are predominant in arthropods, especially in insects, and supergroup F seems to rank third. Host taxa have been studied very unevenly for Wolbachia symbionts, and here, we turn to one of largely unexplored insect families: Acrididae.

On the basis of five genes subject to multilocus sequence typing, we investigated the incidence and genetic diversity of Wolbachia in 41 species belonging three subfamilies (Gomphocerinae, Oedipodinae, and Podisminae) collected in Turkey, Kazakhstan, Tajikistan, Russia, and Japan, making 501 specimens in total.

Our results revealed a high incidence and very narrow genetic diversity of Wolbachia. Although only the strains belonging to supergroups A and B are commonly present in present, the Acrididae hosts here proved to be infected with supergroups B and F without A-supergroup variants. The only trace of an A-supergroup lineage was noted in one case of an inter-supergroup recombinant haplotype, where the ftsZ gene came from supergroup A, and the others from supergroup B. Variation in the Wolbachia haplotypes in Acrididae hosts within supergroups B and F was extremely low. A comprehensive genetic analysis of Wolbachia diversity confirmed specific features of the Wolbachia allelic set in Acrididae hosts. This result can help to elucidate the crucial issue of Wolbachia biology: the route(s) and mechanism(s) of Wolbachia horizontal transmission.
For a signed cyclic graph [Formula: see text], we can construct a unique virtual link [Formula: see text] by taking the medial construction and converting 4-valent vertices of the medial graph to crossings according to the signs. If a virtual link can occur in this way then we say that the virtual link is graphical. In this paper, we shall prove that a virtual link [Formula: see text] is graphical if and only if it is checkerboard colorable. On the other hand, we introduce a polynomial [Formula: see text] for signed cyclic graphs, which is defined via a deletion-marking recursion. We shall establish the relationship between [Formula: see text] of a signed cyclic graph [Formula: see text] and the bracket polynomial of one of the virtual link diagrams associated with [Formula: see text]. Finally, we give a spanning subgraph expansion for [Formula: see text].
Composite material with high thermal conductivity was obtained by the method of thermal sintering of diamonds (synthetic and impact) and copper powder and by further hot isostatic pressing. The content of diamond (the particle size is 20 - 250 μm) in the diamond copper composite was 30 - 45 weight percent.

The coefficient of thermal conductivity of copper diamond composite materials based on synthetic diamonds was measured to be 700 - 750 Wm-1K-1. The coefficient of thermal conductivity of copper diamond composite materials based on impact diamonds was measured to be 850 - 900 Wm-1 K-1. The coefficient of thermal expansion (CTE) was measured to be 5.5 - 6.5 • 10-6/°C for synthetic diamonds and 6.1 - 6.5 •10-6/°C for impact diamonds. The obtained copper diamond composite materials are promising to be used as crystal holders for semiconductor crystals in THz and microwave devices.
GEOMETRY is a software package for the analysis of nucleotide sequences using the method of statistical geometry in sequence space. The package consists of programs performing estimation of the average geometry of sequence quartets, analysis of positional variability and computer simulation of parallel and tree-like sequence divergence with user-defined parameters. It provides an independent tool for evaluation of the reliability of conventional phylogenetic trees and calthration of the time of sequence divergence. GEOMETRY may be of interest for all scientists engaged in the study of molecular phylogeny. The package is available by anonymous FTP from ftp.bionet.nsk.su, directory /incoming/molevol/geom.exe, and will be available from EMBL file server.
Three-site models of the ribosomal elongation cycle are discussed. The controversial experimental data on the interaction between tRNA and the third ribosomal site (E) are presented.

The functional role of the E site in the translocation process is considered. The alternative three-site model based on different tRNA orientation during the elongation cycle on the ribosome is discussed.

It is concluded that the classical two-site model is to be extended on the basis of the recent experimental data.
By using an equivalent form of the uniform Lopatinski condition for 1-shocks, we prove that the stability condition found by the energy method in [A. Morando, Y. Trakhinin and P. Trebeschi, Structural stability of shock waves in 2D compressible elastodynamics, Math. Ann. 378 (2020) 1471–1504] for the rectilinear shock waves in two-dimensional flows of compressible isentropic inviscid elastic materials is not only sufficient but also necessary for uniform stability (implying structural nonlinear stability of corresponding curved shock waves). The key point of our spectral analysis is a delicate study of the transition between uniform and weak stability. Moreover, we prove that the rectilinear shock waves are never violently unstable, i.e. they are always either uniformly or weakly stable.
This paper reports on the results of research into passively modelocked fiber laser with a record-setting optical length of the resonant cavity amounting to 3.8 km.

Significant elongation of the laser resonator led to more than two orders of magnitude increase in the output pulse energy at the same pump radiation power.

At ultra-low (for mode-locked lasers) pulse repetition rate (77 kHz) and pulse duration of 3 ns the energy per pulse reached 3.9 microJ. At this moment this is the highest pulse energy on record generated directly from a mode-locked laser without Q-switching, cavity dumping techniques, or additional optical amplifiers.
In the present Letter, the reaction operator of the main equation of spin chemistry has been modified on the basis of an exactly solvable model. The model contains both the reversible and irreversible transitions. For this model, expression for the reaction operator is more complex due to the expanded basis of spin states. The reaction operator of a phenomenological equation is a particular case of a more general approach and only in the limiting case of the completely irreversible recombination process, these operators coincide.
We present a theory of coherent propagation and energy or power transfer in a low-dimension array of coupled nonlinear waveguides. It is demonstrated that in the array with nonequal cores (e.g., with the central core) stable steady-state coherent multicore propagation is possible only in the nonlinear regime, with a power-controlled phase matching.

The developed theory of energy or power transfer in nonlinear discrete systems is rather generic and has a range of potential applications including both high-power fiber lasers and ultrahigh-capacity optical communication systems.
For diesel engines, dimethyl ether (DME) is widely used in the world, it is a perspective candidate to replace traditional diesel in the future. The consumption of DME as a motor fuel is constantly increasing. DME has a very low propensity to soot formation during combustion, which allows not only to reduce harmful emissions into the atmosphere, but also to improve the completeness of combustion.

To validate available chemical kinetic models for DME combustion, in this work we report our experimental data on the chemical structure of a laminar premixed stoichiometric DME/O 2 /Ar flame stabilized at 1 atm on a flat burner. Flame sampling molecular beam-mass spectrometry is used to obtain spatial distribution of mole fractions of many species in the flame.

The experimental data are compared with the calculation results obtained using PREMIX code and two detailed chemical kinetic mechanisms available from literature for DME combustion.
Macrostomum lignano is a free-living flatworm that is emerging as an attractive experimental animal for research on a broad range of biological questions. One feature setting it apart from other flatworms is the successful establishment of transgenesis methods, facilitated by a steady supply of eggs in the form of single-cell zygotes that can be readily manipulated.

This, in combination with the transparency of the animal and its small size, creates practical advantages for imaging and fluorescence-activated cell sorting in studies related to stem cell biology and regeneration. M. lignano can regenerate most of its body parts, including the germline, thanks to the neoblasts, which represent the flatworm stem cell system. Interestingly, neoblasts seem to have a high capacity of cellular maintenance, as M. lignano can survive up to 210 Gy of γ-irradiation, and partially offset the negative consequence of ageing. As a non-self-fertilizing simultaneous hermaphrodite that reproduces in a sexual manner, M. lignano is also used to study sexual selection and other evolutionary aspects of sexual reproduction. Work over the past several years has led to the development of molecular resources and tools, including high-quality genome and transcriptome assemblies, transcriptional profiling of the germline and somatic neoblasts, gene knockdown, and in situ hybridization.

The increasingly detailed characterization of this animal has also resulted in novel research questions, such as bio-adhesion based on its adhesion-release glands and genome evolution due to its recent whole-genome duplication.
The ancient Egyptian false-door stela of Neferiu from the Denderite nome has several unusual features: on the right jambs he boasts that “nourished (even) the great in the year of famine” and claims that the god Iqer awarded him prosperous longevity; on the left he is depicted as a portly old man; etc. How can these peculiarities be explained? During the First Intermediate Period in the Denderite nome false-door stelae were a luxury appropriate only for top officials and their nearest relatives. However, the false door of Neferiu is an exception to this rule. He is not said to have held any office, and although his ranking titles seem relatively high, we know that at that period such titles were often appropriated by provincials devoid of top positions. Thus, on account of his low “official status” (if any at all), Neferiu needed to inventively justify his moral right to his prestigious false door, and this is the purport of his inscription on its right jambs. The reference to “nourishing (even) the great” implies that in the year of famine Neferiu, owing to his wealth and generosity, turned out to be a more useful person for his town than even its top officials. His claims that he “was aggrandized beyond great men and officials” and praised by “the entire town” also put him on a par with local magnates. His prosperous longevity, “documented” by his “elderly” representation on the left, is said to have been granted by the god Iqer (in gratitude for the salvation of his townspeople, the god’s flock and providers). Meanwhile, it was mostly nomarchs and overseers of priests who attributed their good fortune to the favor of a local god. So, since Neferiu was a man useful for his town no less than its top officials, was he not – just like them – also worthy of a false-door?
This paper explains a method of constructing algebras, starting with the properties of discrimination in elementary discrete systems.

We show how to use points of view about these systems to construct what we call iterant algebras and how these algebras naturally give rise to the complex numbers, Clifford algebras and matrix algebras.

The paper discusses the structure of the Schrödinger equation, the Dirac equation and the Majorana Dirac equations, finding solutions via the nilpotent method initiated by Peter Rowlands.
This paper describes the operation principles and design features of the device for single pulse X-raying of explosive and high-speed processes, developed on the basis of a Tesla transformer with lumped secondary capacitor bank. The circuit with the lumped capacitor bank allows transferring a greater amount of energy to the discharge circuit as compared with the Marks-surge generator for more effective operation with remote X-ray tubes connected by coaxial cables. The device equipped with multiple X-ray tubes provides simultaneous X-raying of extended or spaced objects, stereo imaging, or few-projection tomography.
Neanderthals once inhabited Europe and western Asia, spreading as far east as the Altai Mountains in southern Siberia, but the geographical origin and time of arrival of the Altai populations remain unresolved.

Excavations at Chagyrskaya Cave in the Altai foothills have yielded 90,000 stone artifacts, numerous bone tools, 74 Neanderthal fossils, and animal and plant remains recovered from 59,000- to 49,000-year-old deposits. The Chagyrskaya Neanderthals made distinctive stone tools that closely resemble Micoquian artifacts from eastern Europe, whereas other Altai sites occupied by earlier Neanderthal populations lack such artifacts.

This suggests at least two dispersals of Neanderthals into southern Siberia, with the likely ancestral homeland of the Chagyrskaya toolmakers located 3,000 to 4,000 kilometers to the west, in eastern Europe.
Aim. Evaluation of the possibilities of a new semi-quantitative rapid test for procalcitonin in the diagnosis of multisegmental community-acquired pneumonia. Materials and methods. A one-stage comparative study involved 123 patients hospitalized in a hospital with a confirmed diagnosis of community-acquired pneumonia. The mean age of the patients was 49.521.0 (MSD) years. On the first day of hospitalization, all patients underwent a general clinical examination, chest x-ray, and a plasma procalcitonin level was determined using a semi-quantitative rapid test. Results. Indicators of a new semi-quantitative rapid test for procalcitonin of at least 2 ng/ml are directly related to laboratory and instrumental indicators reflecting the severity of community-acquired pneumonia, namely, the severity of respiratory failure (p=0.001), respiratory rate (p=0.001), and heart rate contractions (p=0.001), systolic blood pressure (p=0.025), oxygen saturation (p=0,001), erythrocyte sedimentation rate (p=0.021), fibrinogen (p=0.003) and high CRB-65 scores (p=0.001). They are also associated with multisegmental community-acquired pneumonia (2=4.7; p=0.030) and complications of this disease, such as hydrothorax (p=0.029) and death (2=22.1; p=0.001). Conclusion. Using a new semi-quantitative rapid test for procalcitonin allows you to optimize the diagnosis of complications of community-acquired pneumonia and determine the high risk of multisegmental pneumonia.
Background Hemoglobin is a tetramer consisting of two α-chains and two β-chains of globin. Hereditary aberrations in the synthesis of one of the globin chains are at the root of thalassemia, one of the most prevalent monogenic diseases worldwide. In humans, in addition to α- and β-globins, embryonic zeta-globin and fetal γ-globin are expressed. Immediately after birth, the expression of fetal Aγ- and Gγ-globin ceases, and then adult β-globin is mostly expressed. It has been shown that in addition to erythroid cells, hemoglobin is widely expressed in nonerythroid cells including neurons of the cortex, hippocampus, and cerebellum in rodents; embryonic and adult brain neurons in mice; and mesencephalic dopaminergic brain cells in humans, mice, and rats. Lately, there is growing evidence that different forms of anemia (changes in the number and quality of blood cells) may be involved in (or may accompany) the pathogenesis of various cognitive and mental disorders, such as Alzheimer’s and Parkinson’s diseases, depression of various severity levels, bipolar disorders, and schizophrenia. Higher hemoglobin concentrations in the blood may lead to hyperviscosity, hypovolemia, and lung diseases, which may cause brain hypoxia and anomalies of brain function, which may also result in cognitive deficits.

Methods In this study, a search for unannotated single-nucleotide polymorphisms (SNPs) of erythroid genes was initially performed using our previously created and published SNP-TATA_Z-tester, which is a Web service for computational analysis of a given SNP for in silico estimation of its influence on the affinity of TATA-binding protein (TBP) for TATA and TATA-like sequences. The obtained predictions were finally verified in vitro by an electrophoretic mobility shift assay (EMSA).

Results On the basis of these experimental in vitro results and literature data, we studied TATA box SNPs influencing both human erythropoiesis and cognitive abilities. For instance, TBP–TATA affinity in the HbZ promoter decreases 6.6-fold as a result of a substitution in the TATA box (rs113180943), thereby possibly disrupting stage-dependent events of “switching” of hemoglobin genes and thus causing erythroblastosis. Therefore, rs113180943 may be a candidate marker of severe hemoglobinopathies with comorbid cognitive and mental disorders associated with cerebral blood flow disturbances. Conclusions The literature data and experimental and computations results suggest that the uncovered candidate SNP markers of erythropoiesis anomalies may also be studied in cohorts of patients with cognitive and/or mental disorders with comorbid erythropoiesis diseases in comparison to conventionally healthy volunteers. Research into the regulatory mechanisms by which the identified SNP markers contribute to the development of hemoglobinopathies and of the associated cognitive deficits will allow physicians not only to take timely and adequate measures against hemoglobinopathies but also to implement strategies preventing cognitive and mental disorders.
A one-dimensional free boundary problem on a motion of a heavy piston in a tube filled with viscous gas is considered.

The system of governing equations and boundary conditions is derived. The obtained system of differential equations can be regarded as a mathematical model of an exterior combustion engine. The existence of a weak solution to this model is proved.

The problem of maximization of the total work of the engine is considered.
The interest in investigating of the compressibility for such materials is related both to the possibility of creating materials with the necessary properties and to the properties of the materials themselves. The results of calculations are compared with the known experimental results of different authors.

The calculations were performed using the model TEC (thermodynamic equilibrium components). The model allows us to take into account the phase transition of germanium under shock-wave action.

The results of numerical experiments upon modeling thermodynamic parameters such as value of pressure and compression of germanium and its alloys with gold are presented. The value of pressure and compression for shock wave loading of pure germanium and alloys with germanium as a component of various compositions are calculated.
The purpose of the present review is to summarize the data related with the structural features of interaction between the human repair enzyme 8-oxoguanine DNA glycosylase (hOGG1) and DNA. The review covers the questions concerning the role of individual amino acids of hOGG1 in the specific recognition of the oxidized DNA bases, formation of the enzyme-substrate complex, and excision of the lesion bases from DNA. Attention is also focused upon conformational changes in the enzyme active site and disruption of enzyme activity as a result of amino acid mutations. The mechanism of damaged bases release from DNA induced by hOGG1 is discussed in the context of structural dynamics.
Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control. Here, we identify the NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway for the G1/S transition. In response to mitogenic stimulation, NUCKS1, a transcription factor, is recruited to chromatin to activate expression of SKP2, the F-box component of the SCF
Место договора финансовой аренды (лизинга)в системе гражданско-правовых договоров Н
Новосибирский государственный университет, НовосибирскС использованием элементарных численных методов построены модели различных колебательных систем.Математический маятник, поршень, движущийся в цилиндре под действием разности давлений в цилиндре, и материальная точка, совершающая колебательные движения по окружности под действием упругой силы, демонстрируют качественно различный характер зависимости между амплитудой и периодом колебаний.С помощью блока численного решения дифференциальных уравнений математического пакета MathCAD изучено движение маятника Капицы с нетривиальной возвращающей силой.Построение двух-и трехмерных графиков в системе MathCAD применено для сложения взаимно перпендикулярных колебаний и получения фигур Лиссажу.Автоколебательные системы представлены в виде моделей RC-генератора с трехзвенной фазовращающей цепью отрицательной обратной связью и генератора Вина.Примером релаксационного генератора является мо
The energy profiles of various configurations of the tetra-n-butylammonium ion (Bu 4 N + ) arising by changing the angle between a pair of butyl ligands, as well as by rotating of various alkyl fragments in gas phase, were calculated using DFT methods.

A hypothesis about the most probable way of changing the conformations of tetra-n-butylammonium ions during the phase transitions in highly conductive solid electrolytes was proposed.
It is well known that the early life experiences affect stress responses and other physiological and behavioral traits in adulthood. Both rat and human studies have shown that early postnatal effects are associated with methylation of the hippocampal glucocorticoid receptor gene exon 1 7 (rat) and 1‐F (human) promoters. Methylation of these sites is also seen following methionine administration in adult rats.

To address this question, we fed pregnant rats a methyl‐supplemented diet that resulted in alteration of the stress response. However, methylation analysis revealed no effect of methyl supplements on methylation patterns of the glucocorticoid receptor gene exon 1 7 promoter in offspring.

These results suggest that the pre‐ and postnatal effects of methyl supplementation have different mechanisms.
In contrast to diradicals connected by alternant hydrocarbons, only a few studies have addressed diradicals connected by nonalternant hydrocarbons and their heteroatom derivatives. Here, the synthesis, structure, and magnetic properties of pyrrole-2,5-diyl–linked bis(nitronyl nitroxide) and bis(iminonitroxide) diradicals are described. The diradicals show characteristic electron spin resonance spectra in dilute glassy solutions, from which conclusions about the presence of distinct conformations, their symmetry, and interspin distance were made. X-ray diffraction analysis of the diradicals revealed that paramagnetic moieties lie in the plane of the pyrrole ring, because of the formation of an intramolecular hydrogen bond, ONO…H−N, with O…H distances of 2.15–2.23 Å. The N–O groups participating in the formation of H-bonds have greater bond lengths (~1.29 Å) as compared with nonparticipating groups (~1.27 Å). The nitronyl nitroxide and iminonitroxide diradicals showed an intramolecular antiferromagnetic interaction, with J = −77.3 and −22.2 cm−1, respectively (H = −2JS1⋅S2).