Hengzongshu/ArticleAgent huggingface dataset:
Given that biodegraded oils are very heavy (density: 910-950 kg/m3), they are characterized by high boiling point temperatures (145-270°C). Due to the loss of hydrocarbon components, they have higher resin and asphaltene content (9-20%) compared to non-degraded samples.

NMR spectroscopy in combination with elemental analysis was used to study asphaltenes in biodegraded oils from Cenomanian pools of West Siberia. The sampling depths vary from 680 to 1800 m, formation temperatures – from 40°C to 70°C. For comparison, we used the data on asphaltenes in non-biodegraded oils of different genotypes.

Elemental analysis of asphaltenes in biodegraded and unaltered oils of different genotypes revealed an increasing trend for oxygen content in the asphaltenes from biodegraded samples, which may result from the oxidation of structural blocks of asphaltenes during microbial oxidation. It was shown that the aromaticity of the moderately biodegraded terrestrial-aquatic Novoaganskaya samples tends to increase with a decrease in asphaltene saturation, suggesting that the redistribution of structural groups of asphaltenes may be caused by biodegradation processes. High saturation of asphaltenes in strongly biodegraded Gubkinskaya and Novoportovskaya oils, along with a high degree of substitution of aromatic compounds in asphaltenes in Gubkinkaya oils (terrestrial and aquatic-terrestrial genotype) can be attributed to the formation of asphaltenes during strong biodegradation of hydrocarbon components in these oils.
In this paper the beam cleaning effect at Raman conversion of multimode pump radiation in a graded-index fiber is modeled

and the output parameters of Raman laser with multimode pumping based on graded-index fiber with core diameters of 62.5 and 85 um are compared
Analysis of trends in the development of silicon photonics shows the high efficiency regarding the creation of optical sensors. The concept of bimodal sensors, which suggests moving away from the usual paradigm based only on single-mode waveguides and using the inter-mode interaction of guided optical waves in a two-mode optical waveguide, is developed in the present paper. In this case, the interaction occurs in the presence of an asymmetric periodic perturbation of the refractive index above the waveguide surface. Such a system has unique dispersion properties that lead to the implementation of collinear Bragg diffraction with the mode number transformation, in which there is an extremely high dependence of the Bragg wavelength on the change in the refractive index of the environment. This is called the “effect of dispersion-enhanced sensitivity”. In this paper, it is shown by numerical calculation methods that the effect can be used to create optical sensors with the homogeneous sensitivity higher than 3000 nm/RIU, which is many times better than that of sensors in single-mode waveguide structures.
Background and Objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48-54%), but its genetic architecture is unknown and candidate gene studies have produced inconsistent results.

We conducted a genome-wide association study to get insight into the genetic background of CWP. Methods Northern Europeans from UK Biobank comprising 6,914 cases reporting pain all over the body lasting more than 3 months and 242,929 controls were studied. Replication of three lead genome-wide significant single nucleotide polymorphisms (SNPs) was attempted in 6 independent European cohorts (N=43,080; cases=14,177). Genetic correlations with risk factors, tissue specificity, and colocalization were examined.

Results Three genome-wide significant loci were identified ( rs1491985, rs10490825, rs165599 ) residing within the genes RNF123, ATP2C1 , and COMT . The RNF123 locus was replicated (meta-analysis p=0.0002), the ATP2C1 locus showed suggestive association (p=0.0227), and the COMT locus was not replicated. Partial genetic correlation between CWP and depressive symptoms, body mass index, age of first birth, and years of schooling were identified. Tissue specificity and colocalization analysis highlight the relevance of skeletal muscle in CWP. Conclusions We report a novel association of RNF123 locus with CWP and suggest a role of ATP2C1 , consistent with a role of calcium regulation in CWP. The association to COMT , one of the most studied genes in chronic pain field, was not confirmed in the replication analysis.
We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data sample containing 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We observe a signal with a significance of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat) +0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/- 0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l- nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first measurement of the Ds+K- invariant mass distribution in these decays, which is dominated by a prominent peak around 2.6 GeV/c^2.
The Production and Distributed Analysis system (PanDA) is a pilot-based workload management system that was originally designed for the ATLAS Experiment at the LHC and to use with grid sites. Since the coming LHC data taking runs will require more resources than grid computing alone can provide, the various LHC experiments are engaged in an ambitious program to extend the computing model to include opportunistically used resources such as High Performance Computers (HPCs), clouds and volunteer computers.

To this end, PanDA is being extended beyond grids and ATLAS to be used on the new types of resources as well as by other experiments. A new key component is being developed, the next generation PanDA Pilot (Pilot 2). Pilot 2 is a complete rewrite of the original PanDA Pilot which has been used in the ATLAS Experiment for over a decade. The new Pilot architecture follows a component-based approach which improves system flexibility, enables a clear workflow control, evolves the system according to modern functional use-cases to facilitate coming feature requests from new and old PanDA users.

This paper describes Pilot 2, its architecture and place in the PanDA hierarchy. Furthermore, its ability to be used either as a command tool or through APIs is explained, as well as how its workflows and components are being streamlined for usage on both grids and opportunistically used resources for and beyond the ATLAS experiment.
The algorithm of the analytical inversion of aerosol size distribution is proposed in this work. As the diffusion battery separates particles into several fractions according to their diffusivity, the total spectrum can be represented as the sum of spectra of fractions. Analytical formulas are derived to calculate mean diameters for particles in different fractions using diffusion battery penetrations as input parameters. The spectra of fractions are approximated by lognormal functions. Two analytical solutions for the aerosol size distribution inversion problem are discussed. The sizing accuracy of analytical solutions is investigated, comparing them with the measurements through transmission electron microscopy using the laboratory-generated NaCl aerosol. The agreement is demonstrated to be within 10% accuracy. It is shown that in case of two-mode size distribution, the spectrum components are well resolved for rather distant peaks (modal diameters of 10 and 300 nm) and poorly resolved for nearby modes (50 and 300 nm). To improve the peak resolution, the procedure of spectrum correction is applied demonstrating an excellent peak separation. Finally, the peak resolution is experimentally verified for the laboratory-generated two-mode spectra of tungsten oxide–NaCl aerosol with the modal diameters of 10 and 60 nm, respectively. Both analytical solutions demonstrated good peak resolution.Copyright © 2018 American Association for Aerosol Research
Objective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1, monocyticchemoattractant protein type 1, MCP-1, lipoprotein (a), LP (a), adhesive molecules sVCAM-1, asymmetric dimethylarginin, ADMA, homocysteine), inflammation (interleukins, IL-6, IL - 8, C-reactive protein, CRP) and with unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis. Material and methods. In 93 men with coronary atherosclerosis without acute coronary syndrome, blood coagulation factors concentrations (factor II, factor VII, factor XII, antithrombin III) were studied in the blood with goal to find their associations with biomarkers of endothelial dysfunction (endothelin 1, MCP-1, LP(a), adhesion molecules sVCAM-1, ADMA, homocysteine), of inflammation (IL-6, IL-8, CRP) and with the presence of unstable plaques in the coronary arteries. Results. In men with unstable atherosclerotic plaques in the coronary arteries, the blood levels of factor VII and factor XII were 1.3 and 1.3 times higher, respectively, compared to men who had stable plaques in the coronary arteries. Correlation links between the blood levels of factor II and factor XII and the presence of unstable atherosclerotic plaques in the coronary arteries (r=0.239 and r=0.250, p <0.05, respectively) have been revealed, as well as between coagulation factors and blood levels of LP(a), sVCAM-1, IL-6 and CRP. Results of logistic regression analysis showed that the relative risk of present of unstable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII (OR=1.008, 95 % CI 1.000-1.017, p=0.048). Conclusion. Our results indicate that elevated blood levels of the Hageman factor may be a new biomarker of probability of unstable atherosclerotic plaques presence in the coronary arteries.
The article examines the history of the doctrine of passive obedience in England during the Stuart period. Traditionally weak financial and legal basis for royal absolutism in England forced monarchs to rely thoroughly on ideology. The concept of passive obedience promoted by the loyal Anglican clergy was one of the key elements of the absolutist ideology of the 17th century. This doctrine was employed as a counterbalance to revolutionary resistance and monarchomach theories embraced by protestant dissenters and papist recusants alike. During the course of the century the doctrine was embraced by numerous representatives of the Church of England’s establishment, including, but not limited to, John Donn, Roger Maynwaring, George Hickes, Edmund Bohun and many others and disseminated via an array of sermons and pamphlets. One component of the doctrine: non-resistance, was particularly stressed. Several political, social and economic factors conditioned the employment of this doctrine. The first instance of its pronouncement followed the failure of the Gunpowder plot and the necessity to refute catholic contractual theories. Charles I saw the doctrine of passive obedience as both the means to maintain social peace and promote fiscal interests. The new impetus the doctrine gained in the later years of the Restoration: an attempt to integrate it into the ‘ancient constitution’ failed, yet the doctrine of passive obedience was taken up as the chief ideological tool by the Anglican church and employed as a mighty instrument of suppressing resistance and dissent. The Glorious Revolution weakened the grasp of the doctrine in the minds of the English, though by no means killed it. Yet, the regime erected by the Convention of 1689 and strengthened by William of Orange claimed as much of its legitimacy in revolutionary resistance. Thus, henceforth the ideas of passive obedience and non-resistance could not be used as the sole basis of legitimate power in England.
Earthworms are an important component of soil fauna even in high latitudes, in the taiga and tundra biomes.It is yet unclear if earthworm populations from these regions are autochtonous or recent invaders.We collected earthworms from approximately from 64° to 73°N from the Kola Peninsula to Chukotka and genotyped it using the COI gene.We found Dendrobaena octaedra, Lumbricus rubellus, and Eisenia nordenskioldi nordenskioldi.Within E. n. nordenskioldi, two cryptic phylogenetic lineages were detected, namely lineages 1 and 9 that were characterized in our previous studies.The western part (from the Kola Peninsula to the Taimyr Peninsula) contained D. octaedra, L. rubellus and both lineages of E. n. nordenskioldi; their COI sequences were closely related to those from very remote (up to several thousand km) populations.On the contrary, in the east (from the basins of the Anabar River to the Chukotka Peninsula) we found solely E. n. nordenskioldi belonging mostly to lineage 9 and its haplotype groups from various parts of this region differed significantly, indicating long-term divergence.Thus, our data suggests that earthworms recolonized northwestern Eurasia in the Holocene, while the climate in its eastern part was sufficient for earthworm survival even during glaciation maximums.
Integrin alpha9 (ITGA9) is one of the less studied integrin subunits that facilitates accelerated cell migration and regulates diverse biological functions such as angiogenesis, lymphangiogenesis, cancer cell proliferation and migration.

In this work, integrin alpha9 expression and its epigenetic regulation in normal human breast tissue, primary breast tumors and breast cancer cell line MCF7 were studied. It was shown that integrin alpha9 is expressed in normal human breast tissue. In breast cancer, ITGA9 expression was downregulated or lost in 44% of tumors while another 45% of tumors showed normal or increased ITGA9 expression level (possible aberrations in the ITGA9 mRNA structure were supposed in 11% of tumors). Methylation of ITGA9 CpG-island located in the first intron of the gene was shown in 90% of the breast tumors with the decreased ITGA9 expression while no methylation at 5'-untranslated region of ITGA9 was observed. 5-aza-dC treatment restored integrin alpha9 expression in ITGA9-negative MCF7 breast carcinoma cells, Trichostatin A treatment did not influenced it but a combined treatment of the cells with 5-aza-dC/Trichostatin A doubled the ITGA9 activation.

The obtained results suggest CpG methylation as a major mechanism of integrin alpha9 inactivation in breast cancer with a possible involvement of other yet unidentified molecular pathways.
The Star graph $$S_n$$ S n , $$n\geqslant 2$$ n ⩾ 2 , is the Cayley graph over the symmetric group $$\mathrm {Sym}_n$$ Sym n generated by transpositions $$(1~i),\,2\leqslant i \leqslant n$$ ( 1 i ) , 2 ⩽ i ⩽ n . This set of transpositions plays an important role in the representation theory of the symmetric group. The spectrum of $$S_n$$ S n contains all integers from $$-(n-1)$$ - ( n - 1 ) to $$n-1$$ n - 1 , and also zero for $$n\geqslant 4$$ n ⩾ 4 .

In this paper we observe methods for getting explicit formulas of eigenvalue multiplicities in the Star graphs $$S_n$$ S n , present such formulas for the eigenvalues $$\pm (n-k)$$ ± ( n - k ) , where $$2\leqslant k \leqslant 12$$ 2 ⩽ k ⩽ 12 ,

and finally collect computational results of all eigenvalue multiplicities for $$n\leqslant 50$$ n ⩽ 50 in the catalogue.
Since its first demonstration in graded-index multimode fibers, spatial beam self-cleaning has attracted a growing research interest. It allows for the propagation of beams with a bell-shaped spatial profile, thus enabling the use of multimode fibers for several applications, from biomedical imaging to high-power beam delivery. So far, beam self-cleaning has been experimentally studied under several different experimental conditions. Whereas it has been theoretically described as the irreversible energy transfer from high-order modes towards the fundamental mode, in analogy with a beam condensation mechanism. Here, we provide a comprehensive theoretical description of beam self-cleaning, by means of a semi-classical statistical mechanics model of wave thermalization. This approach is confirmed by an extensive experimental characterization, based on a holographic mode decomposition technique, employing laser pulses with temporal durations ranging from femtoseconds up to nanoseconds. An excellent agreement between theory and experiments is found, which demonstrates that beam self-cleaning can be fully described in terms of the basic conservation laws of statistical mechanics.
Despite the huge amount of works devoted to the study of mitotic division, there is still a lot of unclear in its mechanisms. For example, insufficient attention has been paid to the processes of cell division in plant forms of different ploidy levels. The literature contains only fragmentary data on haploids in lower plants. This does not allow making any generalizations regarding mitosis in haploids of higher plants.

This article presents the results of a cytological study of mitotically dividing cells of haploid maize plants. The article demonstrates the effectiveness of the well-known Chase method, based on the use of genetic markers and the ig mutation (indeterminate gametophyte) for obtaining and detecting haploids. An effective modification of a simple method of acetocarmine staining of cytological preparations is described.

An essential result obtained is, in our opinion, the detection of a very brief moment in the state of chromosomes in a dividing cell of a haploid maize plant. This moment is characterized by the fact that the chromatids have already separated and turned into independent chromosomes, but have not yet begun their movement under the action of kinetochore microtubules. It is this feature that made it possible to designate this state as late prophase – early prometaphase of mitosis. An equally important feature of the detected moment is the unusual ordered arrangement of chromosomes, which lie parallel to each other close to each other along their entire length with the centromeres located on one line, which can be considered the equator of the fission spindle. The revealed fact allows us to assume that an essential role in the formation of such an arrangement of chromosomes is played by the bond of chromosomes with the equator of the nuclear membrane and their subsequent connection with the equator of the fission spindle.
The article presents materials of the excavations of Qin burials near the area of the Mausoleum of Qin Shihuang. To the west of its outer wall, a burial ground of nine large tombs has been excavated, which are dated to the age of the empire's formation, however the possibility of an earlier date is not excluded.

The most interesting finds were reportedly from grave M1, which included bronze bells and ritual vessels, iron armament, jade scepters and disks, gold buckles, numerous metal figurines of people and animals, including gold and silver camels. One more golden trail leading from the depths of Asia to the Yellow River's valley can be found in the nine golden buttons from grave M5, excavated at Taerpo, in the area of Xianyang, the ancient capital of the state of Qin. Some of the buttons were decorated by granulation, and it is highly likely that such technology could have penetrated into China from Western Asia.

This discovery made it possible to raise the question of the formation of a stable trade 'highway', later determined as the Great Silk Road, already in the late period of the Qin Dynasty (the last quarter of 3 rd century BC), but not under the rule of Han Emperor Wu-di (156–87 BC), as previously thought. Perhaps a high-ranking dignitary buried in grave M1 was chief administrator of this project, therefore he can be denoted as 'Qin Zhang Qian'. The materials obtained from these excavations once again illustrate how the Qin Empire, despite its short life and inglorious death, managed to lay many important pillars of future development.
Results of experimental studies of the round hydrogen microjet interaction with a coaxial air for supersonic speed jets efflux are presented in this work. It is shown that interaction of round and coaxial air jets at their supersonic efflux leads to appearance of a train small/large-scale and, on the contrary, large/small-scale supersonic cells on a resultant jet with growth and reduction of speed of its efflux, respectively. It is found that the result of the round and coaxial air jets interaction at their supersonic efflux does not depend on geometrical parameters of a round and coaxial exit nozzle.
We present non-standard optical Ramsey schemes that use pulses individually tailored in duration, phase, and frequency to cancel spurious frequency shifts related to the excitation itself. In particular, the field shifts and their uncertainties of Ramsey fringes can be radically suppressed (by 2-4 orders of magnitude) in comparison with the usual Ramsey method (using two equal pulses) as well as with single-pulse Rabi spectroscopy. Atom interferometers and optical clocks based on two-photon transitions, heavily forbidden transitions, or magnetically induced spectroscopy could significantly benefit from this method. In the latter case these frequency shifts can be suppressed considerably below a fractional level of 10^{-17}. Moreover, our approach opens the door for the high-precision optical clocks based on direct frequency comb spectroscopy.
Key exchange algorithm based on homomorphic encryption idea is reviewed in this article. This algorithm might be used for safe messaging using one-time pads. Since algorithm requires a low amount of computing resources, this method might be used in IoT to provide authentication.
Functionality of the non-coding transcripts encoded by the human genome is the coveted goal of the modern genomics research. While commonly relied on the classical methods of forward genetics, integration of different genomics datasets in a global Systems Biology fashion presents a more productive avenue of achieving this very complex aim. Here we report application of a Systems Biology-based approach to dissect functionality of a newly identified vast class of very long intergenic non-coding (vlinc) RNAs. Using highly quantitative FANTOM5 CAGE dataset, we show that these RNAs could be grouped into 1542 novel human genes based on analysis of insulators that we show here indeed function as genomic barrier elements. We show that vlincRNAs genes likely function in cis to activate nearby genes. This effect while most pronounced in closely spaced vlincRNA–gene pairs can be detected over relatively large genomic distances. Furthermore, we identified 101 vlincRNA genes likely involved in early embryogenesis based on patterns of their expression and regulation. We also found another 109 such genes potentially involved in cellular functions also happening at early stages of development such as proliferation, migration and apoptosis. Overall, we show that Systems Biology-based methods have great promise for functional annotation of non-coding RNAs.
Light absorption due to transitions between the edge and two-dimensional (2D) states of a 2D topological insulator (TI) is considered in the Volkov-Pankratov model. It is shown that the transitions are allowed only for the in-plane electric field orthogonal to the TI edge. It is found that the absorption is accompanied by pure spin photocurrent along the TI edge. A possibility of spin current measurement using polarized luminescence from 2D TI quantum dots is discussed.