Hengzongshu/ArticleAgent huggingface dataset:
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.
The electronic structure of a molecular quantum ring (stacks of 40-unit cyclic porphyrin polymers) is characterized via scanning tunneling microscopy and scanning tunneling spectroscopy. Our measurements access the energetic and spatial distribution of the electronic states and, utilizing a combination of density functional theory and tight-binding calculations, we interpret the experimentally obtained electronic structure in terms of coherent quantum states confined around the circumference of the π-conjugated macrocycle.

These findings demonstrate that large (53 nm circumference) cyclic porphyrin polymers have the potential to act as molecular quantum rings.
Thermocapillary breakdown of thin horizontal layer of ethanol when heated from a localized heat source was studied experimentally. The influence of layer depth on the breakdown process was investigated. Evolution of the layer thickness in the heating point and deformation profile were being monitored and the critical thickness of the layer was evaluated using confocal technique. Pulsations of layer thickness over the heating area before the breakdown have been found.
Interband photoluminescence (PL) and stimulation emission (SE) from HgTe/HgCdTe quantum well (QW) heterostructures are studied in 5–20 µm wavelength range in regard to long‐wavelength lasing applications.

The authors obtain carrier lifetimes using time‐resolved photoconductivity measurements and show that the dominating mechanism of carrier recombination changes from the radiative process to the non‐radiative one as the bandgap is decreased, limiting the 'operating' temperature for SE.

The authors suggest that decreasing the QW width should reverse the balance in carrier recombination in favor of radiative processes and demonstrate 75 K improvement in the 'operating' temperature in structure with narrower QW.
The article deals with the social and political situation in the Kasminsk, Tarsminsk, Titovsk, and Morozovsk volosts (districts) of the Kuznetsk uyezd (area), Tomsk Province, in 1917–1919. The territories in question were inhabited by long-time Russian residents. The Revolution affected the largest settlements. Titovsk area was included in the system of Kuznetsk area people's assembly, while Kasminsk district was under the supervision of the so-called zemstvo from the very beginning. Soldiers from reserve regiments of Tomsk and Novonikolaevsk were sent to field work and had a destructive impact on the local life. Anarchists (G. F. Rogov, I. P. Novoselov, P. K. Lubkov, I. M. Drozhzhin, etc.) and their military units played a significant role in the partisan and rebel movement. V. P. Shevelyov-Lubkov (1892–1939) became the most famous Red leader in the territory. He was an old settler from the village of Shipitsina in the Titovsk district and a decorated army veteran. The Whites were defeated in the late 1919, which brought no relief as anarchist squads maintained their attacks on the Soviet troops. In 1921, peasants in the village of Bryukhanovo rebelled. The last pockets of resistance were eliminated as late as in 1922.
Pronghorn (Antilocapridae, 2n = 58) and saola (Bovidae, 2n = 50) are members of Pecora, a highly diversified group of even-toed hoofed mammals. Karyotypes of these species were not involved in chromosome painting studies despite their intriguing phylogenetic positions in Pecora.

To trace the chromosome evolution during very fast radiation of main families from the common Pecoran ancestor, high-resolution comparative chromosome maps of pronghorn and saola with human (HSA) and dromedary camel (CDR) painting probes were established. The human and dromedary camel painting probes revealed 50 and 64 conserved segments respectively in the pronghorn genome, while 51 and 63 conserved segments respectively in the saola genome. Integrative analysis with published comparative maps showed that inversions in chromosomes homologous to CDR19/35/19 (HSA 10/20/10), CDR12/34/12 (HSA12/22/12/22), CDR10/33/10 (HSA 11) are present in representatives of all five living Pecoran families.

The pronghorn karyotype could have formed from a putative 2n = 58 Pecoran ancestral karyotype by one fission and one fusion and that the saola karyotype differs from the presumed 2n = 60 bovid ancestral karyotype (2n = 60) by five fusions. The establishment of high-resolution comparative maps for pronghorn and saola has shed some new insights into the putative ancestral karyotype, chromosomal evolution and phylogenic relationships in Pecora. No cytogenetic signature rearrangements were found that could unite the Antilocapridae with Giraffidae or with any other Pecoran families. Our data on the saola support a separate position of Pseudorigyna subtribe rather than its affinity to either Bovina or Bubalina, but the saola phylogenetic position within Bovidae remains unresolved.
An experiment on generation and transmission of an intensive electron beam through a magnetic mirror has been carried out at the GOL-3 magnetic trap. An adapted theory and numerical modelling were used to find a maximal beam current for which no beam electrons are reflected. The effect of space charge and magnetic mirror of the reflection were taken into account. A comparison of the computed limiting current with experimental value allowed us to validate a hypothesis that the appearance of reflected electrons is responsible for electric breakdown in the electron gun.
The article presents an algorithm for modeling fertility factors, which are discrete variables, taking into account endogeneity. Cross-sectional data for individuals is used.

The main factors influencing the probability of having a child within the next year and the number of children a woman has are described.
We show experimentally and numerically new transient lasing regime between stable single-pulse generation and noise-like generation.

We characterize qualitatively all three regimes of single pulse generation per round-trip of all-normal-dispersion fiber lasers mode-locked due to effect of nonlinear polarization evolution. We study spectral and temporal features of pulses produced in all three regimes as well as compressibility of such pulses.

Simple criteria are proposed to identify lasing regime in experiment.
An electron outcoupling scheme was proposed for the high power FELs with optical cavities to avoid the power limitation because of overheating of the reflecting mirrors. This can be realized if the major part of radiation power is emitted at an angle to the optical axis. For this, the electron beam should be bunched and then slightly rotated in an undulator of the FEL. At the NovoFEL facility, the electron outcoupling system is installed on the third FEL, based on the multi-turn energy recovery linac. It consists of three undulators, dipole correctors, and two quadrupole lenses assembled between them. There are two different configurations of the system, with electrons deflected in either the second or the third undulator. The electron beam dynamics calculations, current experimental results, and planned experiments are discussed.
A theory describing experimental beam profiles of multimode fiber Raman lasers is developed: random mode coupling, Kerr self-cleaning and spatial filtering play a decisive role in shaping Stokes beams, whereas depleted pump beams remain insensitive.
The influence of the finiteness of the proton radius and mass on the energies of a hydrogen atom and hydrogen-like ions in a superstrong magnetic field is studied.

The finiteness of the nucleus size pushes the ground energy level up leading to a nontrivial dependence of the value of critical nucleus charge on the external magnetic field.
It is known that 1-naphthol, as a result of superelectrophilic (dicationic) activation in superacid media, is able to react with such deactivated aromatic compound as o-dichlorobenzene to give 4-(3,4-dichlorophenyl)-1-tetralone (2), which is a highly valuable intermediate in the synthesis of the antidepressant, sertraline (1) and other useful derivatives. However, the analogous reactivity of 2-naphthol and a variety of naphthalenediols towards o-dichlorobenzene has not been investigated thus far, although the corresponding tetralones, bearing dichlorophenyl moiety, could be of great pharmacochemical interest. In present work, we disclose that 1,5-, 1,6-, and 1,7- naphthalenediols (6a–c) react smoothly with o-dichlorobenzene in the presence of an excess of aluminum chloride or aluminum bromide to give the pairs of isomeric 4-(3,4-dichlorophenyl)- and 4-(2,3-dichlorophenyl)- 5-, 6-, and 7-hydroxy-1-tetralones (10a–c and 11a–c) in high overall yields. 2-Naphthol and 2,7-naphthalenediol (6d) exhibited comparatively lower reactivity, which however was sufficient to obtain the corresponding dichlorophenyl-2-tetralones in moderate yields. The mechanism of these reactions involving superelectrophilic dicationic or even tricationic intermediates, is discussed.
The ambiguity of the NLO BFKL kernels in consequence of the possibility to rearrange radiative corrections to scattering amplitudes between the impact factors and the Green functions permits to write the kernels for the singlet and adjoint representations of the gauge group in the quasiconformal appearance, i.e. in the form where conformal invariance is violated only by running coupling.The differences between standard and quasi-conformal kernels in the momentum space are found.
The changes in the renal function leading to a reduction of medullary blood flow can have a great impact on sodium and water homeostasis and on the long-term control of arterial blood pressure. The RNA-Seq approach was used for transcriptome profiling of the renal medulla from hypertensive ISIAH and normotensive WAG rats to uncover the genetic basis of the changes underlying the renal medulla function in the ISIAH rats being a model of the stress-sensitive arterial hypertension and to reveal the genes which possibly may contribute to the alterations in medullary blood flow. Multiple DEGs specifying the function of renal medulla in ISIAH rats were revealed. The group of DEGs described by Gene Ontology term 'oxidation reduction' was the most significantly enriched one. The other groups of DEGs related to response to external stimulus, response to hormone (endogenous) stimulus, response to stress, and homeostatic process provide the molecular basis for integrated responses to homeostasis disturbances in the renal medulla of the ISIAH rats. Several DEGs, which may modulate the renal medulla blood flow, were detected. The reduced transcription of Nos3 pointed to the possible reduction of the blood flow in the renal medulla of ISIAH rats. The generated data may be useful for comparison with those from different models of hypertension and for identifying the common molecular determinants contributing to disease manifestation, which may be potentially used as new pharmacological targets.
Human apurinic/apyrimidinic endonuclease 1 (APE1) is known to be a critical player of the base excision repair (BER) pathway. In general, BER involves consecutive actions of DNA glycosylases, AP endonucleases, DNA polymerases, and DNA ligases. It is known that these proteins interact with APE1 either at upstream or downstream steps of BER. Therefore, we may propose that even a minor disturbance of protein–protein interactions on the DNA template reduces coordination and repair efficiency. Here, the ability of various human DNA repair enzymes (such as DNA glycosylases OGG1, UNG2, and AAG; DNA polymerase Polβ; or accessory proteins XRCC1 and PCNA) to influence the activity of wild-type (WT) APE1 and its seven natural polymorphic variants (R221C, N222H, R237A, G241R, M270T, R274Q, and P311S) was tested. Förster resonance energy transfer–based kinetic analysis of abasic site cleavage in a model DNA substrate was conducted to detect the effects of interacting proteins on the activity of WT APE1 and its single-nucleotide polymorphism (SNP) variants. The results revealed that WT APE1 activity was stimulated by almost all tested DNA repair proteins. For the SNP variants, the matters were more complicated. Analysis of two SNP variants, R237A and G241R, suggested that a positive charge in this area of the APE1 surface impairs the protein–protein interactions. In contrast, variant R221C (where the affected residue is located near the DNA-binding site) showed permanently lower activation relative to WT APE1, whereas neighboring SNP N222H did not cause a noticeable difference as compared to WT APE1. Buried substitution P311S had an inconsistent effect, whereas each substitution at the DNA-binding site, M270T and R274Q, resulted in the lowest stimulation by BER proteins. Protein–protein molecular docking was performed between repair proteins to identify amino acid residues involved in their interactions. The data uncovered differences in the effects of BER proteins on APE1, indicating an important role of protein–protein interactions in the coordination of the repair pathway.
We report on an extension of the quasi-resonance (QUASR) pulse sequence used for signal amplification by reversible exchange (SABRE), showing that we may target distantly J-coupled 19F-spins. Polarization transfer from the parahydrogen-derived hydrides to the 19F nucleus is accomplished via weak five-bond J-couplings using a shaped QUASR radio frequency pulse at a 0.05 T magnetic field. The net result is the direct generation of hyperpolarized 19F z-magnetization, derived from the parahydrogen singlet order. An accumulation of 19F polarization on the free ligand is achieved with subsequent repetition of this pulse sequence. The hyperpolarized 19F signal exhibits clear dependence on the pulse length, irradiation frequency, and delay time in a manner similar to that reported for 15N QUASR-SABRE. Moreover, the hyperpolarized 19F signals of 3-19F-14N-pyridine and 3-19F-15N-pyridine isotopologues are similar, suggesting that (i) polarization transfer via QUASR-SABRE is irrespective of the nitrogen isotopologue and (ii) the presence or absence of the spin-1/2 15N nucleus has no impact on the efficiency of QUASR-SABRE polarization transfer. Although optimization of polarization transfer efficiency to 19F (P19F ≈ 0.1%) was not the goal of this study, we show that high-field SABRE can be efficient and broadly applicable for direct hyperpolarization of 19F spins.
We search for smooth periodic solutions for the system of quasi-linear equations known as the Lax dispersionless reduction of the Benney moments chain. It is naturally related to the existence of a polynomial in momenta integral for a classical Hamiltonian system with 1,5 degrees of freedom. For the solution in question, it is not known a priori if the system is elliptic or hyperbolic or of mixed type. We consider two possible regimes for the solution. The first is the case of only one real eigenvalue, where we can completely classify the solutions. The second case of strict hyperbolicity is really a challenge. We find a remarkable 2 × 2 reduction which is strictly hyperbolic with one umbilic point but violates the condition of genuine non-linearity.
Новосибирский государственный университет Новосибирск, Россия Аннотация Рассматривается мотив тайны в календарных рассказах А. П. Чехова 1883-1887 гг.В ранних рассказах Чехова ((«Кривое зеркало» (1883), «Страшная ночь» (1884), «То была она!» (1886) и др.) мотив тайны связан со стремлением писателя развенчать веру в сверхъестественные начала.Попытки героев узнать свою судьбу, прибегая к гаданиям, приметам, обрядам и различным эзотерическим практикам, оканчиваются «отрезвляющим» столкновением с действительностью.Мистические явления объясняются посредством логики
We report a measurement of the time-dependent CP asymmetry of B[over ¯]^{0}→D_{CP}^{(*)}h^{0} decays, where the light neutral hadron h^{0} is a π^{0}, η, or ω meson, and the neutral D meson is reconstructed in the CP eigenstates K^{+}K^{-}, K_{S}^{0}π^{0}, or K_{S}^{0}ω.

The measurement is performed combining the final data samples collected at the ϒ(4S) resonance by the BABAR and Belle experiments at the asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The data samples contain (471±3)×10^{6} BB[over ¯] pairs recorded by the BABAR detector and (772±11)×10^{6} BB[over ¯] pairs recorded by the Belle detector.

We measure the CP asymmetry parameters -η_{f}S=+0.66±0.10(stat)±0.06(syst) and C=-0.02±0.07(stat)±0.03(syst). These results correspond to the first observation of CP violation in B[over ¯]^{0}→D_{CP}^{(*)}h^{0} decays. The hypothesis of no mixing-induced CP violation is excluded in these decays at the level of 5.4 standard deviations.
A numerical technique for solving an initial-boundary value problem of the single compressible fluid flow through elastic porous medium is presented. The model of compressible fluid flow in elastic porous medium is derived within the theory of hyperbolic thermodynamically compatible systems of conservation laws that provides a formulation of mathematically and physically well-posed governing equations of physical processes. Numerical method is based on the WENO–Runge–Kutta algorithm. For the boundary flux evaluation the characteristic decomposition and linearized boundary conditions are used. A two-dimensional problem of the fluid inflow into the saturated porous rectangular domain from its left boundary is studied numerically.
Two analogues of Korn's inequality on Heisenberg groups are constructed.

First, the norm of the horizontal differential is estimated in terms of its symmetric part. Second, Korn's inequality is treated as a coercive estimate for a differential operator whose kernel coincides with the Lie algebra of the isometry group. For this purpose, we construct a differential operator whose kernel coincides with the Lie algebra of the isometry group on Heisenberg groups and prove a coercive estimate for this operator.

Additionally, a coercive estimate is proved for a differential operator whose kernel coincides with the Lie algebra of the group of conformal mappings on Heisenberg groups.
Yellow fever is an acute infectious disease of viral nature, the causative agent of which is vector-borne –is transmitted through the bites of infected mosquitoes. Massive epidemics caused by the yellow fever virus are observed in the countries of Africa, South and Central America annually. Imported cases are also registered in non-endemic territories.

The review presents the currently available data on the distribution, structure and classification of the yellow fever virus, the identification of its genetic variants depending on the geographical distribution, as well as modern methods of detection and identification of the pathogen in samples taken from sick and dead people. It considers the possibility of using virological, immunoserological and molecular-genetic methods for the diagnosis of yellow fever in different periods from the onset of the disease and in retrospective studies. The lists of diagnostic drugs of domestic and foreign production for the detection of agent markers (antigen, RNA), as well as specific antibodies of IgM and IgG classes, approved for use on the territory of the Russian Federation, are provided.

The relevance of further development, improvement and introduction into laboratory practice of reagent kits that allow to detect the yellow fever virus in samples from sick people in a short time, with high efficiency and specificity is demonstrated. This will help to establish a diagnosis promptly and conduct timely anti-epidemic measures, as well as to determine the level of the population stratum immune to the pathogen in endemic regions and evaluate the effectiveness of immunization for the vaccinated contingent.
The effect of cryogenic temperature on the formation of solid solutions by mechanical alloying (MA) was studied using synchrotron diffraction and some additional methods. Two systems with different positive enthalpy of mixing (Cu-Ag и Au-Co) were involved. MA by severe plastic deformation at 293 K and 80 K leads to the formation of fcc substitutional solid solutions, with the excess of the equilibrium concentration for both systems. The effect of cryogenic deformation consists in smaller dissolution of the original basic element of the charge (Cu) for Cu-Ag solid solution and in increasing of solute (Co) for Au-Co one. Diffraction experiments were performed at the SR beamline №4 of the VEPP-3 storage ring.
The results of investigation of the transverse flow inhomogeneity effect on the natural and controlled disturbance development in 3D supersonic boundary layer are considered.

The transition curves were measured on a model of a smooth swept wing and on a swept wing with roughness elements of two configurations. The influence of periodic surface roughness on the growth of natural pulsations (without using a discharge) in the boundary layer is determined. In experiments with artificial disturbances it is found that the periodic modulation of mean flow can lead to stabilization of controlled disturbances in supersonic boundary layer on a swept wing.

It was found out that the weak flow inhomogeneity can influence the effectiveness of the active/passive technology of supersonic boundary layer transition control, including the surface microroughness on a swept wing.
The rapid development of renewable energy sources observed in recent years however has a number of limitations for different regions limited by non-price factors such as corruption and opacity of supporting institutions, lack the necessary technology to integrate renewable into the grid, lobbying and support of the interests of the owners of traditional energy sources and others. The article attempts to analyse the factors that affect the consumption of renewable energy sources in three groups of countries, pointing to the greater importance of such indicators as the share of R & d in GDP, the availability of traditional energy resources, oil prices, transparency of institutions for some countries and their lesser importance for others.
The combination of atomic spectroscopy, integrated photonics, and microelectromechanical systems leads the way to the demonstration of microcell-based optical atomic clocks.

Here, we report the short-term stability budget of table-top Cs microcell-stabilized lasers based on dual-frequency sub-Doppler spectroscopy (DFSDS). The dependence of the sub-Doppler resonance properties on key experimental parameters is studied. The detection noise budget and absolute phase noise measurements are in good agreement with the measured short-term frequency stability of the laser beatnote, at the level of 1.1 × 10 − 12 τ − 1 / 2 until 100 s, currently limited by the intermodulation effect from a distributed-feedback laser setup.

The fractional frequency stability of the laser beatnote at 1 s is about 100 times greater than that of commercial microwave chip-scale atomic clocks and validates interest in the DFSDS approach for the development of high-performance microcell-based optical standards.