Hengzongshu/ArticleAgent huggingface dataset:
The nonlinear Schrödinger equation (NLSE) is often used as a master path-average model for fiber-optic transmission lines. In general, the NLSE describes the co-existence of dispersive waves and soliton pulses. The propagation of a signal in such a nonlinear channel is conceptually different from linear systems. We demonstrate here that the conventional orthogonal frequency-division multiplexing (OFDM) input optical signal at powers typical for modern communication systems might have soliton components statistically created by the random process corresponding to the information content. Applying the Zakharov–Shabat spectral problem to a single OFDM symbol with multiple subcarriers, we quantify the effect of the statistical soliton occurrence in such an information-bearing optical signal. Moreover, we observe that at signal powers optimal for transmission, an OFDM symbol incorporates multiple solitons with high probability. The considered optical communication example is relevant to a more general physical problem of the generation of coherent structures from noise.
Главный редакторчлен-корреспондент АН РТ, доктор исторических наук А
Results of the study of species diversity of myxomycetes in North-Eastern Russia are presented. Moist chamber cultures were prepared with samples of leaf litter from Republic of Sakha (Yakutia) and Magadan oblast and with samples of bark from two sample plots in the vicinity of Yakutsk and Neryungri. A total of 49 species in 23 genera, 9 families, and 5 orders were recorded during the study.
A pioneering research on a self-assembly of the magneto-anisotropic module [Re(CN)7]3− with the Mn(III) complexes involving Salen type (N,N′-ethylenebis(salicylideneiminate)) Schiff base (SB) ligands was performed using the known [Mn(3MeOSalen)(H2O)2]2(ClO4)2·H2O (1) and the firstly synthesized [Mn2(5MeSalen)2OAc]PF6 (2). In the case of 1, a slow diffusion of the component solutions led to the ionic compound Ph4P[Mn(3MeOSalen)(H2O)2]2[Re(CN)7]·6H2O (3). The direct mixing of the same solutions has resulted in the microcrystalline nearly insoluble solid [Mn(3MeOSalen)(H2O))4Re(CN)7]ClO4·1.5MeCN·6.5H2O, which is likely to comprise the pentanuclear clusters [(MnIII(SB)(H2O))4Re(CN)7]+. The use of 2 resulted in a 2D-network assembly of octanuclear clusters, [{(Mn(5MeSalen))6(H2O)2Re(CN)7}2Re(CN)7]Cl2(PF6)·H2O (4), incorporating one Re-center in a pentagonal bipyramid coordination environment, while another has strongly distorted capped trigonal prism as a coordination polyhedron. The latter was observed for the first time for Re(IV) complexes. A synthetic challenge to obtain the 0D assemblies with Re:Mn ≥ 3 has yielded a hexanuclear complex [Mn(5MeSalen)H2O(i-PrOH)][(Mn(5MeSalen))5H2O(i-PrOH)2Re(CN)7](PF6)2(OAc)·2i-PrOH (5) being 1D chain via a bridging phenoxyl group. Owing to a low solubility of the final product, an addition of a bulk anion Ph4B− to the MeCN/MeOH solution of [Re(CN)7]3−and 1 in ratio 1:6 resulted in rhenium-free matter [Mn(3MeOSalen)(H2O)2][Mn(3MeOSalen)(H2O)MeCN](Ph4B)2·5MeCN (6).
Heparan sulfate (HS) is an important component of the extracellular matrix and cell surface, which plays a key role in cell–cell and cell–matrix interactions. Functional activity of HS directly depends on its structure, which determined by a complex system of HS biosynthetic enzymes. During malignant transformation, the system can undergo significant changes, but for glioma, HS biosynthesis has not been studied in detail. In this study, we performed a comparative analysis of the HS biosynthetic system in human gliomas of different grades. RT-PCR analysis showed that the overall transcriptional activity of the main HS biosynthesis-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) was decreased by 1.5–2-fold in Grade II-III glioma (p < 0.01) and by 3-fold in Grade IV glioma (glioblastoma multiforme, GBM) (p < 0.05), as compared with the para-tumourous tissue. The inhibition was mainly due to the elongation (a decrease in EXT1/2 expression by 3–4-fold) and 6-O-sulfation steps (a decrease in 6OST1/2 expression by 2–5-fold) of the HS biosynthesis. Heparanase (HPSE) expression was identified in 50% of GBM tumours by immunostaining, and was characterised by a high intratumoural heterogeneity of the presence of the HPSE protein. The detected disorganisation of the HS biosynthetic system in gliomas might be a potential molecular mechanism for the changes of HS structure and content in tumour microenvironments, contributing to the invasion of glioma cells and the development of the disease.
The hybrid Lattice Boltzmann method is adopted for a detailed study of surface wettability effects on evolution of vapor bubbles and temperature field of heat exchange surface at boiling. The simulation results show that the bubble departure diameter increases with an increase of static contact angle, and its value normalized by the capillary length approaches 3 for superlyophobic surface. In the range of contact angles of 110° – 129° the size of the dry area bounded by triple contact line greatly increases compared to the bubble departure diameter. At contact angles θ ⩾ 153° the dry area does not shrink even at the bubble departure stage and the typical film boiling regime is observed. It has been shown that the deterioration of wettability affects the evolution of the temperature field beneath the bubble, which leads to a significant change in the local heat transfer rate.
Inhibition of the activity of the tumor necrosis factor (TNF) has become the main strategy for treating inflammatory diseases. The orthopoxvirus TNF-binding proteins can bind and efficiently neutralize TNF.

To analyze the mechanisms of the interaction between human (hTNF) or mouse (mTNF) TNF and the cowpox virus N-terminal binding domain (TNFBD-CPXV), also the variola virus N-terminal binding domain (TNFBD-VARV) and to define the amino acids most importantly involved in the formation of complexes, computer models, derived from the X-ray structure of a homologous hTNF/TNFRII complex, were used together with experiments. The hTNF/TNFBD-CPXV, hTNF/TNFBD-VARV, mTNF/TNFBD-CPXV, and mTNF/TNFBD-VARV complexes were used in the molecular dynamics (MD) simulations and MM/GBSA free energy calculations.

The complexes were ordered as hTNF/TNFBD-CPXV, hTNF/TNFBD-VARV, mTNF/TNFBD-CPXV and mTNF/TNFBD-VARV according to increase in the binding affinity. The calculations were in agreement with surface plasmon resonance (SPR) measurements of the binding constants. Key residues involved in complex formation were identified.
Wide usage of biologic disease-modifying anti-rheumatic drugs (DMARDs) biosimilars in clinical practice has greatly increased the availability of biologic therapy for rheumatic patients. Nevertheless, not only economic expediency but efficacy and safety are the key principals of any treatment including biologic DMARDs.

40 rheumatoid arthritis patients on basic therapy who had taken at least one course of original rituximab (MabThera®) 1000 mg twice in 2 weeks more than 6 months ago were included. They were switched to equal-dose biosimilar (Acellbia®) by non-medical reasons and were observed throughout the year. At 12, 24 weeks and one year after switching dynamics of the next parameters were evaluated: pain level according to visual analogue scale (VAS), tender joint count (TJC), swollen joint count (SJC), acute inflammatory and immunological markers, disease activity score (DAS28) calculated using erythrocyte sedimentation rate (DAS28-ESR) or C-reactive protein (DAS28-CRP), health assessment questionnaire (HAQ) index and safety profile.

Our investigation revealed that non-medical switching from original rituximab (MabThera®, 'F. Hoffmann-La Roche Ltd.', Switzerland) to its biosimilar (Acellbia®, 'BIOCAD', Russia) has no significant influence on the therapy efficacy and safety.
Using model spontaneously reverting cell lines, c‐ jun , jun B, jun D and c‐ fos oncogene expression was investigated. c‐ jun , but not jun B, jun D or c‐ fos , was overexpressed in highly tumorigenic clones. The reversion of cells to the non‐tumorigenic phenotype resulted in a dramatic decrease in c‐ jun expression. CAT assays revealed that c‐ jun overexpression in tumorigenic cells was associated with higher transcription activity. No correlation between c‐ jun oncogene expression and AP‐1 transcription factor activity in tumorigenic and non‐tumorigenic clones was found.
Using a series of chromosome aberrations a heat shock (hs) inducible site of the Drosophila virilis heat shock puff 20CD has been cytologically localized in the distal 20C subdivision: the hs puff was not observable in chromosome 2 carrying the Df(2)ebTG-52 deficiency; the bands in the proximal 20D subdivision could not autonomously be activated by hs in aberrant chromosomes that have this deficiency or the In(2)ebPC-19 inversion. An electron microscopy (EM) analysis of the successive stages of puff development in the 20CD and 20F regions shows that the 20CD puff is intially formed from the right part of the 20C6-7 band. In the maximally developed puff, the neighboring bands of the 20C and 20D regions are only partially decondensed; they are seen as discrete compact chromatin clumps. Specific differences in the ultrastructural organization and in response to hs have been found between the D. virilis "unusual" 20CD and typical 20F hs puffs.
The present paper concerns the problems and main features of the development of ontology for subject-based intelligent scientific Internet resources. In these resources the ontology is used not only for formalization and systematization of the heterogeneous knowledge, data and information processing facilities, but also for organization of a convenient access to them. Development of ontology providing the above-mentioned functions is a very difficult and laborious process. To facilitate it the methodology including a set of techniques and ontology design patterns, as well as ontology building method using a representative set of base ontologies, is suggested.
ballistic electron transport in suspended semiconductor nanostructures containing high mobility two dimensional electron gas structured with periodical square lattice of artificial scatters — antidots

Thermopower demonstrates magnetic field commensurability oscillations resulting from geometrical resonances similar to those earlier observed in magnetoresistance

the amplitude of thermopower oscillations remains unchanged after the suspension. This can be explained by short Thouless time compared to the time of electron-phonon interaction
Most contributions in this issue are concerned with open source software (OSS) in libraries. Their basic angle is to look at what is being done with OSS in libraries - or what can be done. This contribution takes a broader look. It outlines a number of direct correlations between the functions of libraries and the characteristics of OSS, and by extension, how the principles of OSS can be applied to the distribution of 'open libraries' as a future direction for librarianship.

I will start by drawing a parallel between software and libraries. To draw the comparison, we have to put software and libraries on an equal footing. A library is most commonly thought of as a service. In our context this description is especially true when we are referring to digital libraries. Normally, software will be thought of as something enabling a service like a digital library. But I would like to look at the software itself as a service. Thus, I will treat both libraries and software as services.

Building open libraries requires technical skill current librarians generally don't have. It requires a business sense they have problems perceiving. And it requires a change in purpose that they are slow to accept. Therefore, I am not optimistic about the future of the formal library sector. But, of course, open libraries that are modeled after the open source movement are here to stay.
Low energy p interaction is considered taking into account the polarization of both particles. The corresponding cross sections are calculated using the Nijmegen nucleon-antinucleon optical potential. Then they are applied to the analysis of the polarization buildup which is due to the interaction of stored antiprotons with polarized protons of a hydrogen target. It is shown that, at realistic parameters of a storage ring and a target, the filtering mechanism may provide a noticeable beam polarization in a time comparable with the beam lifetime.
The hippocampus is a crucial part of the limbic system involved both in cognitive processing and in the regulation of responses to stress. Adverse experiences early in life can disrupt hippocampal development and lead to impairment of the hypothalamic‐pituitary‐adrenal axis response to subsequent stressors. In our study, two types of early‐life stress were used: prolonged separation of pups from their mothers (for 3 hours/day, maternal separation, MS) and brief separation (for 15 minutes/day, handling, HD). In the first part of our study, we found that adult female mice (F0) who had experienced MS showed reduced locomotor activity and impairment of long‐term spatial and recognition memory. Analysis of various hippocampal regions showed that MS reduced the number of mature neurons in CA3 of females, which is perhaps a crucial hippocampal region for learning and memory; however, neurogenesis remained unchanged. In the second part, we measured maternal care in female mice with a history of early‐life stress (F0) as well as the behavior of their adult offspring (F1). Our results indicated that MS reduced the level of maternal care in adult females (F0) toward their own progeny and caused sex‐specific changes in the social behavior of adult offspring (F1). In contrast to MS, HD had no influence on female behavior or hippocampal plasticity. Overall, our results suggest that prolonged MS early in life affects the adult behavior of F0 female mice and hippocampal neuronal plasticity, whereas the mothers' previous experience has effects on the behavior of their F1 offspring through disturbances of mother‐infant interactions.
The structural and functional analyses of heterochromatin are essential to understanding how heterochromatic genes are regulated and how centromeric chromatin is formed. Because the repetitive nature of heterochromatin hampers its genome analysis, new approaches need to be developed.

Here, we describe how, in double mutants for Su(var)3-9 and SuUR genes encoding two structural proteins of heterochromatin, new banded heterochromatic segments appear in all polytene chromosomes due to the strong suppression of under-replication in pericentric regions. FISH on salivary gland polytene chromosomes from these double mutant larvae allows high resolution of heterochromatin mapping. In addition, immunostaining experiments with a set of antibodies against euchromatic and heterochromatic proteins reveal their unusual combinations in the newly appeared segments: binding patterns for HP1 and HP2 are coincident, but both are distinct from H3diMetK9 and H4triMetK20. In several regions, partial overlapping staining is observed for the proteins characteristic of active chromatin RNA Pol II, H3triMetK4, Z4, and JIL1, the boundary protein BEAF, and the heterochromatin-enriched proteins HP1, HP2, and SU(VAR)3-7.

The exact cytological position of the centromere of chromosome 3 was visualized on salivary gland polytene chromosomes by using the centromeric dodeca satellite and the centromeric protein CID. This region is enriched in H3diMetK9 and H4triMetK20 but is devoid of other proteins analyzed.
Increase in organism complexity is a global trend in evolution. Qualitatively extended complexity in eukaryotes in comparison to prokaryotes is provided by genome organization and genetic program realization. Genetic mechanisms of encoding biological complexity in pro- and eukaryotes are considered: above-triplet codes, combinatorial analysis of genetical blocks and gene network blocks, and their hierarchical interaction
We present a model-independent approach for New Physics searches in ultraperipheral collisions at the LHC.

The case of long-lived charged particles is considered

and it is shown that it is possible to find them even with the already available LHC data.
The odonate fauna of Tuva in Siberia, Russia, is documented, based mainly on data from expeditions in 1990, 2000 and 2004, and examination of collections preserved in Novosibirsk.

The checklist of Tuvinian Odonata presently includes 47 species. In the southern Ubsu-Nur depression 29 species were recorded (two just there); in the Central Tuvinian depression 34 species (six just there) and in the Todzha depression 32 species (nine just there).

The fauna of the more humid taiga region of Todzha, separated from the arid remainder of Tuva by the Obruchev Mts, contained some forest species but lacked seven species found elsewhere in Tuva. In spite of Todzha's position in the north-east, its fauna showed a more western character and included a population of Calopteryx splendens with a high proportion of androchromic females and males with wings coloured to the tips. Todzha was also inhabited by Enallagma c. cyathigerum with a variably melanized abdomen, while in the Central Tuvinian and Ubsu-Nur depressions, E. c. risi occurred. In Turan and the Upper Kaa-Khem basin, intergradation between both taxa took place. In Todzha, Somatochlora exuberata and S. metallica abocanica were sympatric without intermediate forms and with habitat segregation, thus proving their status as separate species. Todzha was also inhabited by Ophiogomphus obscurus while the rest of Tuva harboured 0. spinicornis. Recorded only from Altai within Kazakhstan, absent from Russian part of Altai. Recorded only from Irkutsk Province, not yet found in Buryatia.
Opisthorchiasis is a dangerous parasitic disease caused by trematodes in the family Opisthorchiidae. One of the causes of this infection is the species Opisthorchis felineus, which is common in the Russian Federation and Western Europe. The disease has a large number of complications and relatively few effective treatments, so nowadays it is relevant to look for new drugs for the treatment of opisthorchiasis, with the maximum antiparasitic and minimal side effect. In this work, a potentially anthelmintic effect of the methanol extract of the golden chanterelle mushroom (Cantharellus cibarius) was investigated. In in vitro experiments, the significantly reduced mobility and survival rates of juvenile O. felineus specimens with increasing concentrations (10-1000 pg/ml) of the C. cibarius extract were shown. In in vivo studies, administration of the C. cibarius extract on the first day after parasitic infection of inbred C57BL/6 mice resulted in a decrease of the number of helminths in the bile ducts of the liver, evaluated 6 weeks after infection. In another series of experiments, administration of the C. cibarius extract for 7 days to mice infected with O. felineus for five weeks had no anthelmintic effect. In both cases, the state of the infected hosts, evaluated by a number of physiological and biochemical parameters (relative weight of organs, blood indices), did not deteriorate, indicating that there was no adverse effect of the C. cibarius extract. The results obtained suggest that the C. cibarius extract might have anthelmintic properties if applied as parasite larvae excyst.
This work presents the results from a study of the structure and transport properties of Ca-doped La2NiO4+δ. La2−xCaxNiO4+δ (x = 0–0.4) materials that were synthesized via combustion of organic-nitrate precursors and characterized by X-ray diffraction (XRD), in situ XRD using synchrotron radiation, thermogravimetric analysis (TGA) and isotope exchange of oxygen with C18O2. The structure was defined as orthorhombic (Fmmm) for x = 0 and tetragonal (I4/mmm) for x = 0.1–0.4. Changes that occurred in the unit cell parameters and volume as the temperature changed during heating were shown to be caused by the excess oxygen loss. Typical for Ruddlesden–Popper phases, oxygen mobility and surface reactivity decreased as the Ca content was increased due to a reduction in the over-stoichiometric oxygen content with the exception of x = 0.1. This composition demonstrated its superior oxygen transport properties compared to La2NiO4+δ due to the enhanced oxygen mobility caused by structural features. Electrochemical data obtained showed relatively low polarization resistance for the electrodes with a low Ca content, which correlates well with oxygen transport properties.
Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran 11 and 3-oxabicyclo [3.3.1]nonane 12 scaffolds were discovered. These monoterpene-derived compounds were synthesized through preliminary isomerization of (+)-3-carene to (+)-2-carene followed by reaction with heteroaromatic aldehydes. All the compounds inhibit the TDP1 enzyme at micro- and submicromolar levels, with the most potent compound having an IC50 value of 0.65 μM. TDP1 is an important DNA repair enzyme and a promising target for the development of new chemosensitizing agents. A panel of isogenic clones of the HEK293FT cell line knockout for the TDP1 gene was created using the CRISPR-Cas9 system. Cytotoxic effects of topotecan (Tpc) and non-cytotoxic compounds of the new structures were investigated separately and jointly in the TDP1 gene knockout cells. For two TDP1 inhibitors, 11h and 12k, a synergistic effect was observed with Tpc in the HEK293FT cells but was not found in TDP1 −/− cells. Thus, it is likely that the synergistic effect is caused by inhibition of TDP1. Synergy was also found for 11h in other cancer cell lines. Thus, sensitizing cancer cells using a non-cytotoxic drug can enhance the efficacy of currently used pharmaceuticals and, concomitantly, reduce toxic side effects.
Recent genome-wide studies have reported about 600 genes potentially influencing neuroticism. Little is known about the mechanisms of their action. Here, we aimed to conduct a more detailed analysis of genes whose polymorphisms can regulate the level of neuroticism. Using UK Biobank-based GWAS summary statistics, we performed a gene-based association analysis using four sets of genetic variants within a gene differing in their protein coding properties. To guard against the influence of strong GWAS signals outside the gene, we used the specially designed procedure. As a result, we identified 190 genes associated with neuroticism due to their polymorphisms. Thirty eight of these genes were novel. Within all genes identified, we distinguished two slightly overlapping groups comprising genes that demonstrated association when using protein-coding and non-coding SNPs. Many genes from the first group included potentially pathogenic variants. For some genes from the second group, we found evidence of pleiotropy with gene expression. We demonstrated that the association of almost two hundred known genes could be inflated by the GWAS signals outside the gene. Using bioinformatics analysis, we prioritized the neuroticism genes and showed that the genes influencing the trait by their polymorphisms are the most appropriate candidate genes.
gator codons reading and the elongator codons sequence are analyzed.Such conditions correspond to the situation when one ribosome of polyribosomal complex catches up with another ribosome and stumbles upon it during the mRNA translation.A conclusion is drawn on great significance of the polyribosomal organization of translation apparatus in the regulation of rates and ratio of individual proteins biosynthesis.1• Спирин А. С., Гаврилова JI.П. Рибосома,-Μ.: Наука, 1971 -254 с. 2. Lengyel P. The process of translation: a bird's-eye view//Ribosomes.-New.