Hengzongshu/ArticleAgent huggingface dataset:
A series of 1,2-, 1,4-disubstituted or 1,2,4-trisubstituted anthraquinone-based compounds was designed, synthesized, characterized and biologically evaluated for anticancer efficacy. 2- or 4-arylated 1-hydroxy-9,10-antraquinones (anthracene-9,10-diones) were prepared by Suzuki–Miyaura cross-coupling reaction of 1-hydroxy-2-bromoanthraquinone, 1-hydroxy-4-iodoanthraquinone or 1-hydroxy-2,4-dibromoanthraquinone with arylboronic acids. The cross-coupling reaction of 2,4-dibromo-9,10-anthraquinone with arylboronic acids provide a convenient approach to 2,4-bis arylated 1-hydroxyanthraquinones with a variety of aryl substituent in the 2 and 4 position. The cytotoxicity of new anthraquinone derivatives was evaluated using the conventional MTT assays. The data revealed that six of the aryl substituted compounds among the entire series 3, 15, 16, 25, 27, 28 were comparable potent with the commercially available reference drug doxorubicin on the human glioblastoma cells SNB-19, prostate cancer DU-145 or breast cancer cells MDA-MB-231 and were relatively safe towards human telomerase (h-TERT)immortalized lung fibroblasts cells. The results suggested that the in vitro antitumor activity of synthesized 2-aryl, 4-aryl- and 2,4-diaryl substituted 1-hydroxyanthraquinones depends on the nature of the substituent within the cyclic backbone. Docking interaction of 2-, 4-substituted and 2,4-disubstituted 1-hydroxyanthraquinones indicates intercalative mode of binding of compounds with DNA topoisomerase. The interaction with the DNA of 4-aryl-13, 15, 16 and 4-(furan-3-yl)-23 1-hydroxyanthraquinones was experimentally confirmed through a change in electroforetic mobility. Further experiments with 1-hydroxy-4-phenyl-anthraquinone 13 demonstrated that the compound induced cell cycle arrest at sub-G1 phase in DU-145 cells in the concentration 1.1 μM, which is probably achieved by inducing apoptosis. 4-Arylsubstituted 1-hydroxyanthraquinones 13 and 16 induced the enhancement of DNA synthesis on SNB19 cell lines.
The present paper describes a numerical code for simulation of detonation flows on hybrid computational clusters (CPU/GPU). The code can solve 1D, 2D and 3D unsteady Euler equations for multispecies chemically reacting flows using high-order shock-capturing TVD schemes and a finite-rate chemistry solver. The implementation is based on the OpenMP, MPI and CUDA technologies allowing for both flexibility and computational efficiency of the code. The program is verified on the analytical Zeldovich-von Neumann-Doering solution for the 1D detonation wave in H2/O2 mixture. Some examples of 2D computations are also given.
Our aim was to study the association of hostility with the DRD4, DAT, MAOA genes in an open male population of 25–64 years old. A representative sample of men aged 25–64 years (n = 657 men, average age 44.3 ± 0.4 years) was examined in 1994–1995 and 45–64 years old (n = 781 men, average age - 56.48 ± 0.2 years) in 2003–2005 using the methods proposed by the WHO international program “MONICA-psychosocial” and “HAPIEE”. All respondents completed the hostility questionnaire on their own. Genotyping of the DRD4, DAT and MAOA gene polymorphisms was carried out. It was established that the level of hostility in the male population was 76.9% in the group of 25–64 years old and 60.3% in the group of 45–64 years old. Genotypes 4/6, 4/7 of the DRD4 gene are reliably associated with a high level of hostility; the genotype 4/4 of the DRD4 gene is associated with an average and lower level of hostility. There was no association of individual genotypes and VNTR alleles of DAT gene polymorphism with different levels of hostility. It was found that among individuals with low-active alleles of the MAOA-L gene (alleles 2 and 3), a high level of hostility was more common - 50.9%. The results of constructing a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2.103 (95% CI 1.137–3.889, p = 0.018). Based on the received data we can assume that the long alleles of the DRD4 gene and the low-level allele of the MAOA-L gene are associated with hostility.
Objective. To analyse the mechanism of Sheuermann’s disease genetic determination in a representative samples of pedigrees and to identify its hereditary phenotypic signs. Material and Methods. Patients with Scheuermann’s disease (90 probands and 385 relatives of 1st–3rd relation degree) were examined using clinical-genetical, optical topographical, and radiological methods. Results. Scheuermann’s disease incidence among closest relatives of the probands was 0.143 in sisters (n = 21), 0.476 in brothers (n = 21), 0.250 in mothers (n = 84), and 0.743 in fathers (n = 35). These values significantly exceed the incidence in general population, what confirms a familial aggregation of Scheuermann’s disease. The incidence was higher in brothers and fathers of the probands than in their sisters and mothers, respectively. Both parents have been examined in 32 probands. Out of these families 5 had both parents unaffected, 22 families had affected fathers, 4 families had affected mothers, and 1 family had both parents affected. This also indicates that men are more predisposed to Scheuermann’s disease than women. Conclusion. Segregation analysis has shown that Scheuermann’s disease is a genetically dependent pathology inherited by autosomal dominant type and controlled by major gene with full pentrance in boys and 50 % penetrance in girls.
This paper reports on the excitation of atomic spectra of tap water vapor using an inductive discharge.

It is shown that at a RF source frequency of 27 MHz and a plasma power output from 500 to 600 W, a steady discharge exists to pressures of 10-2 atm. Plasma temperature was determined by the Boltzmann plot method and was approximately 5500 K. At this temperature, it was possible to detect sodium ions dissolved in water.

This suggests that an inductive discharge in water vapor can be used to determine the presence of impurities.
Ultramafic lamprophyres (UMLs) are mantle rocks that provide important information about the composition of specific carbonate–silicate alkaline melts in the mantle as well as the processes contributing to their origin. Minerals of the spinel group typically occur in UMLs and have a unique “genetic memory.” Investigations of the spinel minerals from the UMLs of the Chadobets complex show the physicochemical and thermodynamic features of the alkaline rocks’ crystallization. The spinels of these UMLs have four stages of crystallization. The first spinel xenocrysts were found only in damtjernite pipes, formed from mantle peridotite, and were captured during the rising of the primary melt to the surface. The next stages of the spinel composition evolution are related to the high-chromium spinel crystallization, which changed to a high-alumina composition. The composition then changed to magnesian ulvöspinel–magnetites with strong decreases in the Al and Cr amounts caused by the release of carbon dioxide, rapid temperature changes, and crystallization of the main primary groundmass minerals such as phlogopite and carbonates. Melt inclusion analyses showed the predominance of aluminosilicate (phlogopite, clinopyroxene, and/or albite) and carbonate (calcite and dolomite) daughter phases in the inclusions that are consistent with the chemical evolution of the Cr-spinel trend. The further evolution of the spinels from magnesian ulvöspinel–magnetite to Ti-magnetite is accompanied by the formation of atoll structures caused by resorption of the spinel minerals.
Objective of the Review: To systematise the information on MODY (Maturity-Onset Diabetes of the Young) during pregnancy. Key Points. MODY in pregnant patients should be distinguished from typical gestational diabetes mellitus, since these conditions require early pregnancy management. The article discusses combined criteria for differential diagnosis of types of diabetes mellitus in pregnancy and indications for molecular genetic testing. We describe clinical cases demonstrating the dependence of pregnancy outcomes on whether the foetus inherits the mutation or not. Also, the article describes the outlooks of non-invasive diagnosis of mutation status of the foetus and possible modification of therapy depending on the result. Conclusion. Diagnosis and therapy of MODY is a burning issue since there are no algorithms and the clinical experience is quite sparse. Keywords: MODY, gestational diabetes mellitus, GCK-MODY, HNF1A-MODY.
Background: Rare Earth Elements (REEs) control methanol utilization in both methane- and methanol-utilizing microbes. It has been established that the addition of REEs leads to the transcriptional repression of MxaFI-MeDH [a two-subunit methanol dehydrogenase (MeDH), calcium-dependent] and the activation of XoxF-MeDH (a one-subunit MeDH, lanthanum-dependent). Both enzymes are pyrroquinoline quinone-dependent alcohol dehydrogenases and show significant homology; however, they display different kinetic properties and substrate specificities.

Results: In this study we investigated the steady-state growth of Methylomicrobium alcaliphilum 20ZR in media containing calcium (Ca) or lanthanum (La, a REE element). Three complementary global-omics approaches-RNA-seq transcriptomics, proteomics, and metabolomics-were applied to investigate the mechanisms of improved growth vs. carbon conversion. Cells grown with La showed the transcriptional activation of the xoxF gene, a homolog of the formaldehyde-activating enzyme (fae2), a putative transporter, genes for hemin-transport proteins, and nitrate reductase. In contrast, genes for mxaFI and associated cytochrome (mxaG) expression were downregulated. Proteomic profiling suggested additional adjustments of the metabolic network at the protein level, including carbon assimilation pathways, electron transport systems, and the tricarboxylic acid (TCA) cycle. Discord between gene expression and protein abundance changes points toward the possibility of post-transcriptional control of the related systems including key enzymes of the TCA cycle and a set of electron-transport carriers. Metabolomic data followed proteomics and showed the reduction of the ribulose-monophosphate (RuMP) pathway intermediates and the increase of the TCA cycle metabolites.

Conclusion: Cells exposed to REEs display higher rates of growth but have lower carbon conversion efficiency compared to cells supplemented with Ca. The most plausible explanation for these physiological changes is an increased conversion of methanol into formate by XoxF-MeDH, which further stimulates methane oxidation but limits both the supply of reducing power and flux of formaldehyde into the RuMP pathway.
In order to speed up the calculation of tsunami wave propagation, the field-programmable gate array (FPGA) microchip is used. This makes it possible to achieve valuable performance gain with a modern regular personal computer.

The two half-step MacCormack scheme was used herein for numerical approximation of the shallow water system. We studied the distribution of tsunami wave maximal heights along the coast of the southern part of Japan. In particular, the dependence of wave maximal heights on the particular tsunami source location was investigated. Synthetic 100 × 200 km sources have realistic parameters corresponding to this region.

As observed numerically, only selected parts of the entire coast line are subject to dangerous tsunami wave amplitudes. The particular locations of such areas strongly depend on the location of the tsunami source. However, the extreme tsunami heights in some of those areas can be attributed to local bathymetry. The proposed hardware acceleration to compute tsunami wave propagation can be used for rapid (say, in a few minutes) tsunami wave danger evaluation for a particular village or industrial unit on the coast.
We continue studying of the random walk introduced in [1].

The distribution of the random walk jumps changes under successive achievement regulatory boundaries. The regulation is intended to keep under control the range of trajectories. At the same time the structure of the process allows the trajectories stay some time outside the band adjustments.

The paper establishes limit theorems for the distribution of the maximum possible excess of the upper regulatory barrier.
In the recently proposed ABEL model, the Earth was born as a dry planet without atmosphere and ocean components at 4.56 Ga. From 4.37 to 4.20 Ga, bio-elements, such as carbon (C), hydrogen (H), oxygen (O), and nitrogen (N), were secondarily accreted on the Earth. This two-step formation model of the Earth is referred to as the advent of the bio-elements model (ABEL Model) and the event of the advent of bio-elements (water component) is referred to as ABEL Bombardment. It is evident that the solid Earth originated from enstatite chondrite-like dry material because of its oxygen isotopic composition and similar isotopes. On the other hand, the Earth's water originated primarily from carbonaceous chondrite material based on the hydrogen isotopic ratio. The ABEL model successfully explains this enigma between solid Earth and water. In addition, the importance of the secondary accretion of oxidizing bio-elements should be emphasized because this event became a precursor to initiating the metabolism for life to emerge on a highly reductive planet. If ABEL Bombardment had not occurred, life would never have emerged on the Earth. Therefore, ABEL Bombardment was one of the most important events for this planet to evolve into a habitable planet. Moreover, ABEL Bombardment is thought to be the trigger to switch from stagnant lid tectonics to plate tectonics on this planet because of the injection of volatiles into the initial dry Earth.
Minichannel cooling systems show great potential for small scale electronics.

In this paper we analytically and numerically investigate flow with evaporation in open triangular minichannels without upper gas flow. It models processes either in a groove or in an individual channel. From the laws of mass, momentum and energy conservation we derive equations for mean velocity and for the depth of the liquid. These equations have been solved numerically. The viscosity limits maximum fluid speed and causes the formation of dry spots.

The heat flux reaches 40kW/m 2 for initial liquid velocity 2 m/s. It is demonstrated that triangular or grooved channels even without upper gas flow are perspective for cooling systems.
The results of experimental and theoretical modeling of free-convection flows in the melt of the plume conduit and in the mushroom-shaped head are presented.

It was shown that the plumes with the mushroom-shaped heads can be responsible for the batholith formation. The main parameters of such plumes are estimated.
Detailed tracing of an exhaust plume from a rocket's initial trajectory is a scientifically and diagnostically useful technique. It can provide detailed information on the atmosphere's mean winds, wind shears, turbulent regime, and physical state over a wide altitude range from 50 to 200 km.

We analyze Soyuz rocket exhaust plumes from Plesetsk on 21 May 2009 and 27 June 2011. The rocket plumes studied, related to the initial rocket trajectory, are essentially twilight phenomena as seen from the ground using wideband spectrum cameras, that is, the Sun should be below the horizon by 6°. For the first time, we analyze the dynamics of rocket exhaust products at the initial trajectory in the mesosphere and lower thermosphere using detailed photographic imaging taken from the ground.

The analysis uncovered significantly different atmospheric states and underlying dynamics. The first case showed highly dynamical conditions in the mesosphere, characterized by vortex structures, wind shears, and small-scale turbulent eddies. A characteristic balloon-shaped trail was observed at altitudes between 105 and 160 km. In the second case, we show evidence that the rocket exhaust trail persisted without any changes during its motion from Plesetsk via Denmark to the UK for 9 h, indicating extremely stable atmospheric conditions. This case introduces a new state of the summer mesosphere - remarkably quiet conditions, probably never observed before.
The article presents the results of the study of the experience of the COVID-19 pandemic in the context of tolerance of uncertainty. Respondents (N = 2,837) answered a series of questions regarding how they are dealing with the COVID-19 situation, and MSTAT-II questionnaire. It was found that the emotional background is dominated by such emotions as fear, irritation, anxiety and sadness. Tolerance of uncertainty turned out to be negatively associated with all negative emotions, which allows us to consider it as a resource that reduces negative experience in the current situation. Data was also obtained regarding the relationship between the characteristics of the COVID-19 pandemic experience with the age and gender of the respondents.
Understanding the genetic architecture of drought tolerance is of great importance for overcoming the negative impact of drought on wheat yield. Earlier, we discovered the critical role of chromosome 2A for the drought-tolerant status of wheat spring cultivar Saratovskaya 29.

A set of 92 single-chromosome recombinant double haploid (SCRDH) lines were obtained in the genetic background of Saratovskaya 29. The lines carry fragments of chromosome 2A from the drought-sensitive cultivar Yanetzkis Probat. The SCRDH lines were used to identify regions on chromosome 2A associated with the manifestation of physiological and agronomical traits under distinct water supply, and to identify candidate genes that may be associated with adaptive gene networks in wheat. Genotyping was done with Illumina Infinium 15k wheat array using 590 SNP markers with 146 markers being polymorphic.

In four identified regions of chromosome 2A, 53 out of 58 QTLs associated with physiological and agronomic traits under contrasting water supply were mapped. Thirty-nine candidate genes were identified, of which 18 were transcription factors. The region 73.8-78.1 cM included the largest number of QTLs and candidate genes. The variation in SNPs associated with agronomical and physiological traits revealed among the SCRDH lines may provide useful information for drought related marker-assisted breeding.
Identifying authorship correctly and efficiently is a difficult problem when the literature is abundant, but poorly recorded.Homonyms are tedious to differentiate.This paper describes how the field of economics has organized itself with respect to author identification.We describe the
Due to the growth of the number of scientific publications, the tasks related to scientific article processing become more actual. Such texts have a special structure, lexical and semantic content that should be taken into account while processing. Using information from knowledge bases can significantly improve the quality of text processing systems.

This paper is dedicated to the entity linking task for scientific articles in Russian, where we consider scientific terms as entities. During our work, we annotated a corpus with scientific texts, where each term was linked with an entity from a knowledge base. Also, we implemented an algorithm for entity linking and evaluated it on the corpus. The algorithm consists of two stages: candidate generation for an input term and ranking this set of candidates to choose the best match. We used string matching of an input term and an entity in a knowledge base to generate a set of candidates. To rank the candidates and choose the most relevant entity for a term, information about the number of links to other entities within the knowledge base and to other sites is used.

We analyzed the obtained results and proposed possible ways to improve the quality of the algorithm, for example, using information about the context and a knowledge base structure. The annotated corpus is publicly available and can be useful for other researchers.
The results of prospection studies at the medieval site Horogoru, in the Gyeonggi-do Province of South Korea, are described.

Using ground-penetrating radar, the defense wall, built of tamped earth and masonry, was reconstructed. The analyses of GPR images and 3D-models of the wall were confirmed and supplemented by archaeological excavations. Prospection studies in the central part of the site have enabled us to assess tentatively the thickness of the habitation layer and its preservation. Structures associated with various archaeological cultures were analyzed.

The results of excavations demonstrated a relative reliability of GPR, which had revealed anomalies at various depths. However, an accurate and complete assessment of the outlines of most structures proved impossible, owing to repeated medieval rebuilding, peculiar accumulation processes, and modern disruption. The GPR analysis of the anomalies indicated several stages of habitation. Early features, dating to the Koguryo period (400–700 AD), include a reservoir and a well, and next to these, heaps of roof tiles. Late features, dating to the Koryo stage (1000–1200 AD), include seven buildings, a stone pavement, and pits with roof tiles. Overall, the results demonstrate the efficiency of geophysical methods for the assessment of the site’s structure and of the preservation of its cultural layers.
The study proceeds and is based on the empirical results of the analysis of the structure of bank capital, carried out for individual countries up to the specified period. These results turned out to be quite contradictory regarding the significance of different determinants of the structure of bank capital.

The article presents a regression analysis of banking determinants and their impact on the capital structure of banks for the period 2011–2019 on an extensive statistical base of the countries of India, Russia, China, the USA and banks in the Eurozone.

It is shown that 1) the capital structure of banks is influenced not only by banking determinants, but also by development conditions, regulatory institutions, the state of the economy, which is evidence of the need to analyze the problems of forming the capital structure of banks by countries, types of banks, etc.; 2) banking determinants between 2011 and 2019 explain the variation in bank capital structure to a significant extent and regulatory action is relevant for all countries. From the point of view of the peculiarities of the formation of the structure of bank capital and the role of the regulator in this case, directions of modification of relevant theories of capital structure are proposed.