Hengzongshu/ArticleAgent huggingface dataset:
Since the 1970s, about a dozen caves and rock shelters have been discovered and explored in the limestone massifs of the Cuc Phuong National Park (North Vietnam), in which stone artifacts, human remains and animal bones belonging to the late Paleolithic-Neolithic period have been found.

Archaeological research of the 2012 joint Russian-Vietnamese archaeological expedition extended the list of archaeological sites with a newly discovered cave Diem with a large number of stone products, the complex of faunal and anthropological material. The height of the cave Diem above sea level is 100 m, the entrance is oriented to the North-East. The illuminated entrance part of the cave has a tube-like shape about 30 m long and 5 to 10 m wide. Extending deep into the limestone massif in the form of karst cavities, the cave has a total area of about 500 m². In 2013, the site explored in 2012 had the excavation area of 5 m². In 2014, the area of the excavation was expanded in the North-West direction by 3 m², thus the total of the investigated area was 9 m². In addition to the mechanically mixed upper layer, which included multi-temporal cultural remains, three large cultural and lithological units, numbering 2 118 stone artifacts belonging to the late Paleolithic – Neolithic were identified during the excavation work. In the first cultural-lithological division, there were 39 fragments of ceramics along with stone products. The anthropological material found is represented by a cluster of highly charred and fragmented human bones, presumably of one person. In layer 2, apart from the stone products researchers found a burial of a man whose bone remains were fragmented but were not exposed to fire, as in layer 1. In the roof of layer 3, there was discovered a burial of a woman. More than 1000 bone fragments of reptiles, birds and mammals were collected within the two lower cultural-lithological units.

The ceramics found in layer 1 of the Diem cave allows us to correlate it with the Neolithic culture of Da But, whose period of existence varies in the range of 7000-4000 ka. A powerful block horizon located in layer 2 indicates a strong earthquake whose traces are observed in the same stratigraphic conditions in all the caves of the region under study. The absence of ceramics in cultural unit 2 can be attributed to the early Holocene period (about 10 000 ka). The estimated age of layer 3 of the Diem cave is currently difficult to define. Based on preliminary results, we can suppose that this location belongs to cave sites of the commune Thanh Yen, such as Con Moong and Mang Chieng. Culturally and chronologically it corresponds to the culture of Hoa Binh.
The concept of informativeness of nonlinear plasma physics scenarios is explained. Natural ideas of developing highly informative models of plasma kinetics are spelled out. A maximally informative version of inelastic scattering of electromagnetic waves by Langmuir waves in a weakly turbulent inhomogeneous plasma is developed with consideration of possible changes in wave polarization. In addition, a new formula for wave drift in spatial positions and wave vectors is derived. New scenarios of the respective wave drift and inelastic scattering are compared with the previous visions. The results indicate the need for further revision of the traditional understanding of nonlinear plasma phenomena.
The problem was formulated by Jean Leray 80 years ago.

The proof of the main result uses Bernoulli's law for a weak solution to the Euler equations.

We prove that this problem has a solution under the sole necessary condition of zero total flux through the boundary.
This article discusses the most significant characteristics of the modernization process. Modernization is the process of acquiring and consolidating the high status of the country in the modern era. The status of the country is expressed in its high international economic, geopolitical, social and cultural competitiveness.

The modern era is a historical period when the competitiveness of the country was determined, first of all, by the relative level of its industrial development.

Accordingly, industrialization should be recognized as the main content of modernization. Secondary parameters of modernization, its additional prerequisites are the processes of urbanization, bureaucratization, massification, scientific and technical development and the development of military power.
Mechanistic insight into the semihydrogenation of 1-butyne and 2-butyne on Cu nanoparticles supported on partially dehydroxylated silica (Cu/SiO2-700)

was obtained using parahydrogen
Telomeric and subtelomeric regions are essential for genome stability and regular chromosome replication. In this work, we have characterized the wheat BAC (bacterial artificial chromosome) clones containing Spelt1 and Spelt52 sequences, which belong to the subtelomeric repeats of the B/G genomes of wheats and Aegilops species from the section Sitopsis.

The BAC library from Triticum aestivum cv. Renan was screened using Spelt1 and Spelt52 as probes. Nine positive clones were isolated; of them, clone 2050O8 was localized mainly to the distal parts of wheat chromosomes by in situ hybridization. The distribution of the other clones indicated the presence of different types of repetitive sequences in BACs. Use of different approaches allowed us to prove that seven of the nine isolated clones belonged to the subtelomeric chromosomal regions. Clone 2050O8 was sequenced and its sequence of 119 737 bp was annotated. It is composed of 33% transposable elements (TEs), 8.2% Spelt52 (namely, the subfamily Spelt52.2) and five non-TE-related genes. DNA transposons are predominant, making up 24.6% of the entire BAC clone, whereas retroelements account for 8.4% of the clone length. The full-length CACTA transposon Caspar covers 11 666 bp, encoding a transposase and CTG-2 proteins, and this transposon accounts for 40% of the DNA transposons. The in situ hybridization data for 2050O8 derived subclones in combination with the BLAST search against wheat mapped ESTs (expressed sequence tags) suggest that clone 2050O8 is located in the terminal bin 4BL-10 (0.95-1.0). Additionally, four of the predicted 2050O8 genes showed significant homology to four putative orthologous rice genes in the distal part of rice chromosome 3S and confirm the synteny to wheat 4BL.

Satellite DNA sequences from the subtelomeric regions of diploid wheat progenitor can be used for selecting the BAC clones from the corresponding regions of hexaploid wheat chromosomes. It has been demonstrated for the first time that Spelt52 sequences were involved in the evolution of terminal regions of common wheat chromosomes. Our research provides new insights into the microcollinearity in the terminal regions of wheat chromosomes 4BL and rice chromosome 3S.
A novel moving frame-of-reference brightness-based laser-induced fluorescence (MFoR-BBLIF) method was developed and demonstrated in downwards co-current air–water annular flows. The method was applied to study the downstream development of individual disturbance waves in flows over a range of conditions (Re L = 276–1321, Re G = 39,500–79,000). In this method, the optical measurement system, and hence, the region of interrogation (ROI) was translated physically along the length of the test-section with a velocity close to that of individual disturbance waves to obtain the velocities of individual disturbance-waves as a function of downstream distance from the inlet. It was found that the velocities of individual disturbance waves increase with both downstream distance and gas–liquid flow conditions. In addition, the variation in the wave velocities was more significant at higher gas and liquid Reynolds numbers. The approach can be integrated with many other contactless measurement methods, and can also be used over a range of translation speeds (not necessarily in a “Lagrangian” manner) to study the evolution of important advecting flow phenomena. Graphic abstract
Tan spot caused by the fungus Pyrenophora tritici-repentis is an important leaf spot disease in wheat growing areas throughout the world. The study aims to identify wheat germplasm resistant to tan spot based on phytopathological screening and molecular marker analysis. A collection of 64 common wheat germplasms, including cultivars and breeding lines from Kazakhstan and CIMMYT, was assessed for tan spot resistance in greenhouse conditions and characterized using the Xfcp623 molecular marker, diagnostic for the Tsn1 gene. All wheat cultivars/lines varied in their reaction to tan spot isolate race 1, ranging from susceptible to resistant. Most accessions studied (53 %) were susceptible to Ptr race 1. Spring wheat cultivars were more susceptible to race 1 than winter wheat cultivars. As a result of genotyping, an insensitive reaction to Ptr ToxA was predicted in 41 wheat cultivars (64 %). The tsn1 gene carriers identified included 27 Kazakhstani and 14 CIMMYT cultivars/lines, demonstrating insensitivity to Ptr ToxA. The majority of the Tsn1 genotype were sensitive to race 1 and showed susceptibility to the pathogen in the field. Disease scores from seedling stage positively correlated with field disease ratings. Of particular interest are 27 wheat accessions that demonstrated resistance to spore inoculation by Ptr race 1, were characterized by insensitivity to ToxA and showed field resistance to the pathogen. The results of this study will contribute to wheat breeding programs for tan spot resistance with Marker Assisted Selection using the closely flanking markers.
Production of hyperpolarized catalyst-free gases and liquids by heterogeneous hydrogenation with parahydrogen (HET-PHIP) can be useful for various technical as well as biomedical applications, including in vivo studies, investigations of mechanisms of industrially important catalytic processes, enrichment of nuclear spin isomers of polyatomic gases, and more. In this regard, the wide systematic search for heterogeneous catalysts effective in pairwise H2 addition required for the observation of PHIP effects is crucial.

Here in this work we demonstrate the competitive advantage of Pd-based bimetallic catalysts for HET-PHIP. The dilution of catalytically active Pd with less active Ag or In atoms provides the formation of atomically dispersed Pd1 sites on the surface of Pd-based bimetallic catalysts, which are significantly more selective toward pairwise H2 addition compared to the monometallic Pd.

Furthermore, the choice of the dilution metal (Ag or In) has a pronounced effect on the efficiency of bimetallic catalysts in HET-PHIP, as revealed by comparing Pd-Ag and Pd-In bimetallic catalysts.
Summary Metagenomic surveys of human microbiota are becoming increasingly widespread in academic research as well as in food and pharmaceutical industries and clinical context. Intuitive tools for exploration of experimental data are of high interest to researchers. Knomics-Biota is a Web-based resource for exploratory analysis of human gut metagenomes. Users can generate analytical reports that correspond to common experimental schemes (like case-control study or paired comparison). Statistical analysis and visualizations of microbiota composition are provided in association with the external factors and in the context of thousands of publicly available datasets. Availability and Implementation The Web-service is available at https://biota.knomics.ru . Contact anna.popenko@knomics.ru or a.tyakht@gmail.com . Supplementary information Supplementary figures are available at Bioinformatics online.
The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October 2021
Glucocorticoids (GC) are crucial regulators of homeostasis and function. Despite its negative side effects, glucocorticoid therapy in neonates is widely used antenatally for accelerating fetal lung maturation in cases of preterm birth. GC action is mediated via glucocorticoid receptors — ligand-activated transcription factors. Cell death and viability in the neonatal brain are regulated by many factors, but the glucocorticoid receptor signalling is high above them.

The present work studies the changes in the expression of genes for apoptosis regulators with Bcl-2 homology (BH) domains (Bcl-xL, Bax, Bim, Bok, Bid) in the neonatal rat hippocampus after dexamethasone (DEX) and CpdA administration. CpdA is a dissociative ligand — glucocorticoid receptor modulator — that shifts glucocorticoid receptor (GR) activity toward transrepression. Using rat pheochromocytoma PC12 cells as a test system, we assessed GR-GR and GR-MR (mineralocorticoid receptor) dimerisation with proximity ligation assay (PLA) assay separately in the nucleus and cytoplasm after DEX and CpdA administration.

Ligands administration to P2 pups caused different patterns of timeline changes in the expression of the studied genes. We observed the first increase in the mRNA level of the genes which have glucocorticoid response element (GRE) (Bcl-xL, Bim) in their promoter 30 min after DEX administration. Activated GR action on cells in the neonatal hippocampus is complex and long-lasting; it could also contain receptor homo- and hetero-dimerisation. An increase in GR-GR dimers in the cell nucleus was observed only after DEX administration. In the cell cytoplasm, we observed a gradual (DEX more than CpdA) increase in the number of both GR-GR and GR-MR dimers.
The effect of glycols on the catalytic properties of phosphate-doped NiMo/Al2O3 catalysts in the hydrotreating of straight-run gas oil (SRGO) was studied.

The NiMo(P)/Al2O3 catalysts were prepared using ethylene glycol (EG), diethylene glycol (DEG), and triethylene glycol (TEG) as additives. The organic agent was introduced into the aqueous impregnation solution obtained by the dissolving of MoO3 in H3PO4 solution, followed by Ni(OH)2 addition. The Raman and UV–Vis studies show that the impregnation solution contains diphosphopentamolybdate HxP2Mo5O23(6−x)− and Ni(H2O)62+, and that these ions are not affected by the presence of glycols. When the impregnation solution comes in contact with the γ-Al2O3 surface, HxP2Mo5O23(6−x)− is decomposed completely. The catalysts were characterized by Raman spectroscopy, low-temperature N2 adsorption, X-ray photoelectron spectroscopy, and transmission electron microscopy.

It is shown that the sulfide catalysts prepared with glycols display higher activity in the hydrotreating of straight-run gas oil than the NiMoP/Al2O3 catalyst prepared without the additive. The hydrodesulfurization and hydrodenitrogenation activities depend on the glycol type and are decreased in the following order: NiMoP-DEG/Al2O3 > NiMoP-EG/Al2O3 > NiMoP-TEG/Al2O3 > NiMoP/Al2O3. The higher activity of NiMoP-DEG/Al2O3 can be explained with the higher dispersion of molybdenum on the surface of the catalyst in the sulfide state.
Spin hyperpolarization can be coherently transferred to other nuclei in field-cycling NMR experiments. At low magnetic fields spin polarization is redistributed in a strongly coupled network of spins. Polarization transfer is most efficient at fields where level anti-crossings (LACs) occur for the nuclear spin-states.

A further condition is that field switching to the LAC positions is non-adiabatic in order to convert the starting population differences into spin coherences that cause time-dependent mixing of states. The power of this method has been demonstrated by studying transfer of photo-Chemically Induced Dynamic Nuclear Polarization (photo-CIDNP) in N-acetyl-tryptophan. We have investigated the magnetic field dependence and time dependence of coherent CIDNP transfer and directly assessed nuclear spin LACs by studying polarization transfer at specific field positions.

The proposed approach based on LACs is not limited to CIDNP but is advantageous for enhancing NMR signals by spin order transfer from any type of hyper-polarized nuclei.
This paper represents a pedagogical introduction to low-energy effective field theories. In some of them, heavy particles are “integrated out” (a typical example—the Heisenberg–Euler EFT); in some, heavy particles remain but some of their degrees of freedom are “integrated out” (Bloch–Nordsieck EFT). A large part of these lectures is, technically, in the framework of QED. QCD examples, namely decoupling of heavy flavors and HQET, are discussed only briefly. However, effective field theories of QCD are very similar to the QED case, and there are just some small technical complications: more diagrams, color factors, etc. The method of regions provides an alternative view at low-energy effective theories; this is also briefly introduced.
Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis.
In eukaryotic ribosomes, the conserved protein uS19, formerly known as S15, extends with its C-terminal tail to the decoding site. The cross-linking of uS19 to the A site codon has been detected using synthetic mRNAs bearing 4-thiouridine (s4U) residues.

Here, we showed that the A-site tRNA prevents this cross-linking and that the P site codon does not contact uS19. Next, we focused on determining uS19-mRNA interactions in vivo by applying the photoactivatable-ribonucleoside enhancing cross-linking and immunoprecipitation method to a stable HEK293 cell line producing FLAG-tagged uS19 and grown in a medium containing s4U. We found that when translation was stopped by cycloheximide, uS19 was efficiently cross-linked to mRNA regions with a high frequency of Glu, Lys and, more rarely, Arg codons.

The results indicate that the complexes, in which the A site codon is not involved in the formation of the mRNA-tRNA duplex, are present among the cycloheximide-arrested 80S complexes, which implies pausing of elongating ribosomes at the above mRNA regions. Thus, our findings demonstrate that the human ribosomal protein uS19 interacts with mRNAs during translation elongation and highlight the regions of mRNAs where ribosome pausing occurs, bringing new structural and functional insights into eukaryotic translation in vivo.
We propose and evaluate through extensive numerical modelling a novel distributed hybrid amplification scheme combining first and secondorder Raman pumping which gives reduced signal power excursion over a wide spatial-spectral range of 80 nm in C+L-bands.
The cold atmospheric pressure plasma jet interaction with the bio-target is studied in the plasma experiment, 2D fluid model simulations, and with MTT and iCELLigence assays of the viability of cancer cells. It is shown, for the first time, that the use of the grounded substrate under the media with cells considerably amplifies the effect of plasma cancer cell treatment in vitro. Plasma devices with cylindrical and plane geometries generating cold atmospheric plasma jets are developed and tested. The sequence of the streamers which forms the plasma jet is initiated with a voltage of 2.5–6.5 kV applied with the frequency 40 kHz. We suggest using the grounded substrate under the bio-target during the plasma jet treatment of cancer cells. The analysis of the measured plasma spectra and comparison of OH-line intensity for different voltages and gas flow rates allows us to find a range of optimal plasma parameters for the enhanced OH generation. The time-dependent viability is measured for human cell lines, A431 (skin carcinoma), HEK 293 (kidney embryonic cells), and A549 (human lung adenocarcinoma cells) after the plasma jet treatment. The results with cell-based experiments (direct treatment) performed with various plasma jet parameters confirm the maximum efficiency of the treatment with the optimal plasma parameters.
This paper is devoted to a mathematical model of a chaotic dynamics of a polymer chain in water.

The model consists of a parabolic equation that is derived according to the self-consistent field approach. This model is employed for the numerical simulation of a biological sensor that detects the presence of a specific protein in the fluid. It includes a non-local operator of integration not only over the past time interval as in the problems with memory but also over the future time interval.

The sensor is absolutely simple and seems to be new. Besides that, the suggested equation is interesting from the mathematical point of view. It is unusual for parabolic problems.
An experimental study of effect a pair of weak shock waves on the supersonic boundary layer of a flat plate with a blunt leading edge with Mach number M = 2.5 and zero angle of attack was performed. The radius of bluntness of the leading edge was r = 2.5 mm. The measurements were carried out using a hot wire anemometer. The paper presents a complex flow structure on the surface of the model with a blunt leading edge. It is found that the supersonic boundary layer on a flat plate with a blunt leading edge is very sensitive and susceptible to the effect of a pair of weak shock waves. High-intensity peaks were found in the regions of the disturbed flow. It is specially noted that the largest level of mass flow pulsations in the boundary layer occurred under the effect of a trailing edge of a weak shock "N-wave".
Information visualization is a process of transformation of large and complex abstract forms of information into the visual forms, strengthening cognitive abilities of users and allowing them to take the most optimal decisions.A graph is an abstract structure that is widely used to model complex information for its visualization.In the paper, we consider a system aimed at supporting of visualization of big amounts of complex information on the base of attributed hierarchical graphs.
We report a measurement of the branching fraction and final-state asymmetry for the $\bar{B}^{0}\to K^{0}_{S}K^{\mp}\pi^{\pm}$ decays.

The analysis is based on a data sample of 711 $\rm{fb}^{-1}$ collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider.

We obtain a branching fraction of $(3.60\pm0.33\pm0.15)\times10^{-6}$ and a final-state asymmetry of $(-8.5\pm8.9\pm0.2)\%$, where the first uncertainties are statistical and the second are systematic. Hints of peaking structures are seen in the differential branching fractions measured as functions of Dalitz variables.
Calcium phosphate bions (CPB) are biomimetic mineralo-organic nanoparticles which represent a physiological mechanism regulating the function, transport and disposal of calcium and phosphorus in the human body. We hypothesised that CPB may be pathogenic entities and even a cause of cardiovascular calcification.

Here we revealed that CPB isolated from calcified atherosclerotic plaques and artificially synthesised CPB are morphologically and chemically indistinguishable entities. Their formation is accelerated along with the increase in calcium salts-phosphates/serum concentration ratio. Experiments in vitro and in vivo showed that pathogenic effects of CPB are defined by apoptosis-mediated endothelial toxicity but not by direct tissue calcification or functional changes in anti-calcification proteins.

Since the factors underlying the formation of CPB and their pathogenic mechanism closely resemble those responsible for atherosclerosis development, further research in this direction may help us to uncover triggers of this disease.