Hengzongshu/ArticleAgent huggingface dataset:
The lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory functions of AT, acting as a collector of lipolysis products and adipokines. In its turn, hormones and adipocytokines that produced in adipocytes (including leptin, adiponectin, IL-6, TNF-α, etc.) affect the function of lymphatic endothelial cells and control the growth of lymphatic vessels. Cooperation between LS and AT becomes pathogenetically and clinically important in lymphedema and obesity. It is known that both primary and secondary lymphedema are characterized by increased fat accumulation which is associated with the severity of lymphostasis and inflammation. Similarly, in obesity, the drainage function of LS is impaired, which is accompanied by perilymphatic mononuclear infiltration in the AT. The development of these changes is facilitated by endocrine dysfunction of adipocytes and impaired production of adipocytokines. The increase in the production of inflammatory mediators and the disruption of the traffic of inflammatory cells causes a further deterioration in the outflow of interstitial fluid and exacerbates the inflammation of the AT, thereby forming a vicious circle. The role of lymphangiogenesis in AT remodeling in obesity needs further research. Another promising area of research is the study of the role of intestinal LS in the development of obesity and related disorders. It has been shown that the transport of chylomicrons from the intestine depends on the expression of a number of molecular mediators (VEGF-C, DLL-4, neuropilin-1, VEGFR-1, CD36/FAT, etc.)in the endotheliocytes of the intestinal lymphatic vessels, as well as the functioning of «push-button» and “zippering” junctions between endothelial cells. New approach to the treatment of obesity based on blockade of lymphatic chylomicrontransport has been experimentally substantiated. Further identification of the molecular mechanisms and signaling pathways that determine the remodeling of AT in lymphedema and obesity are likely to provide new approaches to the treatment of these diseases.
The results are self-consistent and in agreement with the static multi-anvil compression data of Litasov et al. (J. Appl. Phys. 113, 093507 (2013)) and the theoretical data of Zeng et al. (J. Phys. Chem. B 114, 298 (2010)). These high pressure and high temperature ( HPHT ) data with high precision firstly complement and close the gap between the resistive heating and the shock compression experiment.

Here we report that the equation of state (EOS) of Mo is obtained by an integrated technique of laser-heated DAC and synchrotron X-ray diffraction. The cold compression and thermal expansion of Mo have been measured up to 80 GPa at 300 K and 92 GPa at 3470 K, respectively. The P - V - T data have been treated with both thermodynamic and Mie–Grüneisen-Debye methods for the thermal EOS inversion.

The results are self-consistent and in agreement with the static multi-anvil compression data of Litasov et al. (J. Appl. Phys. 113, 093507 (2013)) and the theoretical data of Zeng et al. (J. Phys. Chem. B 114, 298 (2010)). These high pressure and high temperature ( HPHT ) data with high precision firstly complement and close the gap between the resistive heating and the shock compression experiment.
The suppression of superconductivity in disordered systems is a fundamental problem of condensed matter physics. Here we investigate the superconducting niobium-titanium-nitride (Nb_{1-x}Ti_{x}N) thin films grown by atomic layer deposition (ALD) where disorder is controlled by the slight tuning of the ALD process parameters. We observe the smooth crossover from the disorder-driven superconductor-normal metal transition (often reffered to as fermionic mechanism) to the case where bosonic mechanism dominates and increasing disorder leads to formation of metal with Cooper pairing. We show that, in moderately disordered films, the transition to zero-resistance state occurs in a full agreement with the conventional theories of superconducting fluctuations and Berezinskii-Kosterlitz-Thouless transition. However, the critically disordered films violate this accord showing low-temperature features possibly indicating the Bose metal phase. We show that it is the interrelation between film's sheet resistance in the maximum, R_{max}, of the resistive curve R(T) and R_q = h/4e^2 that distinguishes between these two behaviors. We reveal the characteristic features in magnetoresistance of the critically disordered films with R_{max} > R_q
We report the final results of a study of the ψ(3770) meson using a data sample collected with the KEDR detector at the VEPP-4M electron–positron collider.

The data analysis takes into account interference between the resonant and nonresonant DD¯ production, where the latter is related to the nonresonant part of the energy-dependent form factor FD. The vector dominance approach and several empirical parameterizations have been tried for the nonresonant FDNR(s).

Our results for the mass and total width of ψ(3770) areM=3779.2−1.7+1.8−0.7+0.5−0.3+0.3MeV,Γ=24.9−4.0+4.6−0.6+0.5−0.9+0.2MeV, where the first, second and third uncertainties are statistical, systematic and model, respectively. For the electron partial width two possible solutions have been found:(1)Γee=154−58+79−9+17−25+13eV,(2)Γee=414−80+72−26+24−10+90eV. Our statistics are insufficient to prefer one solution to another. The Solution (2) mitigates the problem of non-DD¯ decays but is disfavored by potential models. It is shown that taking into account the resonance–continuum interference in the near-threshold region affects resonance parameters, thus the results presented cannot be directly compared with the corresponding PDG values obtained ignoring this effect.
Age-Related Hearing Impairment (ARHI) is one of the frequent sensory disorders registered in 50% of individuals over 80 years. ARHI is a multifactorial disorder due to environmental and poor-known genetic components.

In this study, we present the data on age-related hearing impairment of 48 heterozygous carriers of mutation IVS1+1G>A (GJB2 gene) and 97 subjects with GJB2 genotype wt/wt in the Republic of Sakha/Yakutia (Eastern Siberia, Russia). This subarctic territory was found as the region with the most extensive accumulation of mutation IVS1+1G>A in the world as a result of founder effect in the unique Yakut population isolate. The GJB2 gene resequencing and detailed audiological analysis in the frequency range 0.25, 0.5, 1.0, 2.0, 4.0, 8.0 kHz were performed in all examined subjects that allowed to investigate genotype-phenotype correlations between the presence of single mutation IVS1+1G>A and hearing of subjects from examined groups.

We revealed the linear correlation between increase of average hearing thresholds at speech frequencies (PTA0.5,1.0,2.0,4.0 kHz) and age of individuals with GJB2 genotype IVS1+1G>A/wt (rs = 0.499, p = 0.006860 for males and rs = 0.427, p = 0.000277 for females). Moreover, the average hearing thresholds on high frequency (8.0 kHz) in individuals with genotype IVS1+1G>A/wt (both sexes) were significantly worse than in individuals with genotype wt/wt (p<0.05). The age of manifestation of hearing impairment in carriers of genotype IVS1+1G>A/wt was estimated to be ∼40 years (rs = 0.504, p = 0.003). These findings demonstrate that the single IVS1+1G>A mutation (GJB2) is associated with age-related hearing impairment (ARHI) of the IVS1+1G>A carriers in the Yakuts.
The analysis uses 772×10^6 BB pairs produced in e+e-→Υ(4S) data recorded by the Belle experiment at the KEKB asymmetric-energy e+e- collider.

The tagging B meson in the decay is fully reconstructed in a hadronic decay mode. On the signal side, we reconstruct the decay B → D(*)πℓν (ℓ=e,μ).

The measured branching fractions are in good agreement with the current world average values.
LaCoO 3 samples were obtained by the hydrothermal and citrate methods.

The dynamics of the phase transformations of the initial hydroxo compounds into the oxide state and the subsequent reduction in a hydrogen-containing mixture were studied by the differential thermal analysis and X-ray diffraction methods.

The results of the catalytic tests in the syngas conversion showed that the path of conversion depends on the phase composition of the catalyst in the oxide state. In contrast to the standard CoAl sample, alcohols prevail in the liquid products formed on LaCoO 3 catalysts.
We proposed the following heuristic decision-making rule: 'IF {an excess of a protein relating to the nervous system is an experimentally known physiological marker of low pain sensitivity, fast postinjury recovery, or aggressive, risk/novelty-seeking, anestheticlike, or similar agonistic-intolerant behavior} AND IF {a single nucleotide polymorphism (SNP) causes overexpression of the gene encoding this protein} THEN {this SNP can be a SNP marker of the bias in dominance} WHILE {underexpression corresponds to subordination} AND vice versa.' These proteins are known as key factors of human social behavior.

Using this decision-making rule, we analyzed 231 human genes of neuropeptidergic, non-neuropeptidergic, and neurotrophinergic systems that encode neurotrophic and growth factors, interleukins, neurotransmitters, receptors, transporters, and enzymes. We analyzed all the 5052 SNPs within the 70 bp promoter region upstream of the position where the protein-coding transcript starts, which were retrieved from databases Ensembl and dbSNP using our previously created public Web service SNP_TATA_Comparator (beehive.bionet.nsc.ru/cgi-bin/mgs/tatascan/start.pl). This promoter region contains all the known TATA-binding protein (TBP)-binding sites.

As a result, we found 556 and 552 candidate SNP markers of the human bias in dominance and subordination. On this basis, we determined that 231 human genes under study are subject to natural selection against underexpression (significance p < 0.0005), which equally supports the human bias in domination and subordination such as the norm of a reaction (plasticity) of the human social hierarchy. That is why, using mice as an animal model of human inheritance, we found that both domination and subordination biases are inherited from generation to generation from parents to offspring. Our results equally fit both sides of the century-old unsettled scientific debate on whether both aggressiveness and the social hierarchy among humans are caused by genetic inheritance (e.g., Freud and Lorenz) or by nongenetic social education from childhood to the oldest age (e.g., Berkowitz and Fromm).
The propagation of X chromosome inactivation is thought to be mediated by the cis-limited spreading of the nonprotein coding Xist transcript.

In this report we have investigated the localization of Xist RNA on rodent metaphase chromosomes. Analysis of X:autosome rearrangements revealed that restricted propagation of X inactivation into cis-linked autosomal material is reflected by a corresponding limited spread of Xist RNA.

We show that Xist RNA exhibits a banded pattern on the inactive X and is excluded from regions of constitutive heterochromatin. The banding pattern suggests a preferential association with gene-rich, G-light regions. We discuss these results in the context of models for the function of Xist RNA in the propagation of X inactivation.
The profile of electrostatic potential in the expander of mirror trap is considered. It is shown that potential drop at the wall depends strongly on distribution function of trapped electrons. Self consistent potential profile is calculated assuming Maxwell distribution of the trapped particles. Iterative numerical scheme is used to calculate the potential which holds plasma quasi-neutrality. The potential drop at Child-Langmuir sheath is governed by ambipolarity of loss along magnetic field line je = ji. The depletion of the well between the mirror and the sheath cause increasing of the drop. The approach based on bounce-averaging is proposed to solve kinetic equation for trapped electrons.
Collective cell migration is a complex process that happens during normal development of many multicellular organisms, as well as during oncological transformations.
We review here new advances in the synthesis and investigation of iron(II) coordination compounds with tris(pyrazol-1-yl)methane and its derivatives as ligands.

The complexes demonstrate thermally induced spin crossover accompanied by thermochromism.

Factors that influence the nature and temperature of the spin crossover are discussed.
In this paper the influence of dispersed catalysts obtained in situ based on various metals (Mo, Ni, Fe, Co) has been studied on the yield and properties of liquid products in a slurry-reactor at a temperature of 425 °С and a pressure of 20 MPa.

The most active catalytic compositions for the process of catalytic steam cracking of oil (Mo and Mo-Fe) were selected. In the presence of dispersed Mo and Mo-Fe catalysts the samples of the semisynthetic oils were produced. In the rectification process the gasoline, diesel, oil and residual fractions were allocated. The selected fractions were analyzed by physicochemical methods for a wide range of performance in comparison with the initial heavy oil.

The efficiency of Mo-Fe catalysts for obtaining semisynthetic oil with an increased content of light fractions (i.b.p. – 360 °С) during the catalytic steam cracking of heavy oil was shown.
Mathematical model is formulated for description of thermophysical processes at laser welding of metal plates for the case when modifying nanoparticles of refractory compounds (nanopowder inoculators -NPI) are introduced into the weld pool.

Specially prepared nanoparticles of refractory compounds serve here as crystallization centers, i.e. in fact they are exogenous inoculants on which surface clusters are grouped.This can be used to control the melt crystallization process and formation of its structure, and, therefore, properties of the weld seam.

As an example, calculation results of the butt welding of aluminum alloy and steel plates are presented.The results of calculation and experimental data comparison are shown.
Glucocorticoid responsive elements (GREs) located -252 to -209 by upstream and +1011 to +1054 bp downstream of the transcription initiation site of the mouse metallothionein-I (mMT-I) gene were identified in transient experiments. However, the promoter region of the mMT-I gene (-330 to +70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.
In this paper we derive equations of micropolar fluid with variable concentration of polar particles. Such fluids have non-symmetrical stress tensor and exhibit micro-rotations. To illustrate the derived equations, we consider a pressure driven flow between two parallel planes.
The present paper reports on the combined stereoscopic particle image velocimetry (PIV) and planar laser induced fluorescence (PLIF) measurements of turbulent transport for model swirl burners without combustion. Two flow types were considered, namely the mixing of a free jet with surrounding air for different swirl rates of the jet (Re = 5 × 103) and the mixing of a pilot jet (Re = 2 × 104) with a high-swirl co-flow of a generic gas turbine burner (Re = 3 × 104). The measured spatial distributions of the turbulent Reynolds stresses and fluxes were compared with their predictions by gradient turbulent transport models. The local values of the turbulent viscosity and turbulent diffusivity coefficients were evaluated based on Boussinesq’s and gradient diffusion hypotheses. The studied flows with high swirl were characterized by a vortex core breakdown and intensive coherent flow fluctuations associated with large-scale vortex structures. Therefore, the contribution of the coherent flow fluctuations to the turbulent transport was evaluated based on proper orthogonal decomposition (POD). The turbulent viscosity and diffusion coefficients were also evaluated for the stochastic (residual) component of the velocity fluctuations. The high-swirl flows with vortex breakdown for the free jet and for the combustion chamber were characterized by intensive turbulent fluctuations, which contributed substantially to the local turbulent transport of mass and momentum. Moreover, the high-swirl flows were characterized by counter-gradient transport for one Reynolds shear stress component near the jet axis and in the outer region of the mixing layer.
The work is devoted to numerical simulation of pulverized-coal combustion processes in the vortex furnace which is a prospective design of a boiler unit for thermal power plants.New modification of this design characterized by additional tangential-injection nozzle located at the bottom of combustion chamber has been studied.Numerical results for the case of Siberian brown coal combustion in this vortex furnace with dual-port loading are presented, including 3-D aerodynamic structure, the fields of temperatures, radiated heat fluxes, species and dispersed phase concentrations, and NOx emissions.
This paper considers the axisymmetric problem of condensation at a boiling liquid outflow in a closed region filled with steam. It has been found that the unsteady condensation is due to the formation of a complex structure of lateral pressure surges, Mach disk, barrel shocks and a wall, on which the pressure exceeds the local saturation pressure.
Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology.Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body.The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band.Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research.Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm 2 .Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.
Primary cultures of human glioblastoma were obtained from the surgical material of patients K. (female, 61 years, Ds: relapse of glioblastoma) and Zh. (female, 60 years, Ds: relapse of glioblastoma).

The effectiveness of a new therapeutic approach aimed at destroying the cancer cell community was evaluated on the primary cell lines of human glioblastoma culture by employing a new strategy of tumor-initiating stem cell synchronization and a domestic strategy of their eradication '3+1'. The key elements of the strategy were the following indicator results: (1) evaluation of the presence of tumor-initiating stem cells in a population of cells from analyzed cultures by their ability to internalize double-stranded labeled DNA (TAMRA+ cells); (2) determination of the reference time points of the repair cycle of DNA interstrand cross-links induced by cross-linking cytostatic mitomycin C; (3) evaluation of cell cycle synchronization; (4) determination of the time (day after therapy initiation) when TAMRA+ cells were synchronously present in phase G1/S of the cell cycle, sensitive to the therapy; and (5) establishment of the TAMRA+ (tumor-initiating stem cells) eradication schedule. The cultures were treated with cross-linking cytostatic mitomycin C and a compositional DNA preparation.

After the treatments, cell division slows down, and the cultures degrade. The K cell line completely degraded within 30 days of observation. The cell number of the Zh culture fell to nearly one-third of the starting value by day 15 of observation. On day 15, this indicator constituted 1/7.45 for mitomycin C and 1/10.28 for mitomycin C + DNA with reference to the control. The main target of the mitomycin C + DNA regimen was TAMRA+ tumor-initiating stem cells of the glioblastoma cell populations. The action of mitomycin C alone or in the combination with DNA demonstrated effective elimination of TAMRA+ tumor-initiating stem cells and the whole primary cultures of human glioblastomas.
Expansins facilitate cell expansion via mediating pH-dependent cell wall (CW) loosening. However, the role of expansins in the control of biomechanical CW properties in the tissue and organ context remains elusive.

We determined hormonal responsiveness and specificity of expression and localization of expansins predicted to be direct targets of cytokinin signalling. We found EXPA1 homogenously distributed throughout the CW of columella/ lateral root cap, while EXPA10 and EXPA14 localized predominantly at the three-cell boundaries of epidermis/cortex in various root zones. Cell type-specific localization of EXPA15 overlaps with higher CW stiffness measured via Brillouin light scattering microscopy. As indicated by both Brillouin frequency shift and AFM-measured Young’s modulus, EXPA1 overexpression upregulated CW stiffness, associated with shortening of the root apical meristem and root growth arrest.

We propose that root growth in Arabidopsis requires delicate orchestration of biomechanical CW properties via tight regulation of various expansins’ localization to specific cell types and extracellular domains.
Hybridization of domestic animal breeds with their wild relatives is a promising method for increasing the genetic diversity of farm animals. Resource populations derived from the hybridization of various breeds of domestic sheep with mouflon and argali are an important source of breeding material. The karyotypes of argali and domestic sheep differ for a Robertsonian translocation, which occurred in the common ancestor of mouflon and domestic sheep (Ovis aries) due to the centric fusion of chromosomes 5 and 11 of the argali (O. ammon) into chromosome 3 of sheep. It is known that heterozygosity for translocation can lead to synapsis, recombination and chromosome segregation abnormalities in meiosis. Meiosis in the heterozygotes for translocation that distinguishes the karyotypes of sheep and argali has not yet been studied. We examined synapsis, recombination, and epigenetic modification of chromosomes involved in this rearrangement in heterozygous rams using immunolocalization of key proteins of meiosis. In the majority of cells, we observed complete synapsis between the sheep metacentric chromosome and two argali acrocentric chromosomes with the formation of a trivalent. In a small proportion of cells at the early pachytene stage we observed delayed synapsis in pericentromeric regions of the trivalent. Unpaired sites were subjected to epigenetic modification, namely histone H2A.X phosphorylation. However, by the end of the pachytene, these abnormalities had been completely eliminated. Asynapsis was replaced by a nonhomologous synapsis between the centromeric regions of the acrocentric chromosomes. By the end of the pachytene, the γH2A.X signal had been preserved only at the XY bivalent and was absent from the trivalent. The translocation trivalent did not differ from the normal bivalents of metacentric chromosomes for the number and distribution of recombination sites as well as for the degree of centromeric and crossover interference. Thus, we found that heterozygosity for the domestic sheep chromosome 3 and argali chromosomes 5 and 11 does not cause significant alterations in key processes of prophase I meiosis and, therefore, should not lead to a decrease in fertility of the offspring from interspecific sheep hybridization.