Hengzongshu/ArticleAgent huggingface dataset:
The very to ultra high energy gamma-ray regime up to several 100 TeV is the key to spectrally resolve the cutoff regime of the long-sought Pevatrons, the Galactic cosmic-ray PeV accelerators. One component of the TAIGA hybrid detector is the TAIGA-HiSCORE shower-front sampling timing array, which currently consists of 28 wide angle (0.6\,sr) air Cherenkov timing stations distributed on an area of 0.25 km$^{2}$, and which will be doubled in area by fall 2017. We report on the status and first results of the HiSCORE timing array after the first 2 operation seasons, including calibration studies on timing and pointing, cross calibration with data from the first TAIGA-IACT, observations with the timing array of a LIDAR operating on the ISS, a measurement of the Cosmic Ray spectrum, and a systematic search for high energy gamma-rays from Galactic sources such as the Crab.
Bluff bodies in a gas or liquid flow are a fairly common phenomenon, which is often found in both natural and technogenic processes. Various structural elements of aerospace transport systems, pipelines, gas turbines, heat exchangers, etc. in many cases can be considered, at least qualitatively, as a two-dimensional cylinder in a flow at some angle of attack. Depending on the specific situation, it may be necessary to suppress or intensify the process of vortex generation, increase or decrease the drag coefficient of the body, decrease or increase the level of noise produced by the body in a flow.

In the presented study, models of circular quasi-two-dimensional or finite cylinders are used as a bluff body model. To control the flow textile materials were used which were previously studied in other works of the co-authors [1]. These materials can cover the cylinders.

The change of effective diameter of the cylinders then is around 1% and is considered insignificant when textile material is applied on cylinder. The fulfillment of these tasks is impossible without knowledge of the mechanisms of formation of the flow under the current flow regimes.
The analysis of gene regulatory networks has become one of the most challenging problems of the postgenomic era. Earlier we developed rSNP_Guide ( http://util.bionet.nsc.ru/databases/rsnp.html ), a computer system and database devoted to prediction of transcription factor (TF) binding sites (TF sites), which can be responsible for disease phenotypes. The prediction results were confirmed by 70 known relationships between TF sites and diseases, as well as by site-directed mutagenesis data.

The rSNP_Guide is being investigated as a tool for TF site annotation. Previously analyzed and characterized cases of altered TF sites were used to annotate potential sites of the same type and at the same location in homologous genes. Based on 20 TF sites with known alterations in TF binding to DNA, we localized 245 potential TF sites in homologous genes.

For these potential TF sites, rSNP_Guide estimates TF–DNA interaction according to three categories: ‘present’, ‘weak’, and ‘absent’. The significance of each assignment is statistically measured.
The two-temperature model of the outflow from a vessel with initial supercritical parameters of medium has been realized.

The model uses thermodynamic non-equilibrium relaxation approach to describe phase transitions. Based on a new asymptotic model for computing the relaxation time, the outflow of water with supercritical initial pressure and super- and subcritical temperatures has been calculated.
We calculate the volumes of the hyperbolic twist knot cone-manifolds using the Schläfli formula. Even though general ideas for calculating the volumes of cone-manifolds are around, since there is no concrete calculation written, we present here the concrete calculations. We express the length of the singular locus in terms of the distance between the two axes fixed by two generators. In this way the calculation becomes easier than using the singular locus directly. The volumes of the hyperbolic twist knot cone-manifolds simpler than Stevedore's knot are known. As an application, we give the volumes of the cyclic coverings over the hyperbolic twist knots.
The evolutionary history of organisms with poor dispersal abilities usually parallels geological events. Collisions of the Indian and Arabian plates with Eurasia greatly changed Asian topography and affected regional and global climates as well as biotic evolution. However, the geological evolution of Asia related to these two collisions remains debated. Here, we used Eranthis , an angiosperm genus with poor seed dispersal ability and a discontinuous distribution across Eurasia, to shed light on the orogenesis of the Qinghai–Tibetan, Iranian and Mongolian Plateaus. Our phylogenetic analyses show that Eranthis comprises four major geographical clades: east Qinghai–Tibetan Plateau clade (I-1), North Asian clade (I-2), west Qinghai–Tibetan Plateau clade (II-1) and Mediterranean clade (II-2). Our molecular dating and biogeographic analyses indicate that within Eranthis , four vicariance events correlate well with the two early uplifts of the Qinghai–Tibetan Plateau during the Late Eocene and the Oligocene–Miocene boundary and the two uplifts of the Iranian Plateau during the Middle and Late Miocene. The origin and divergence of the Mongolian Plateau taxa are related to the two uplifts of the Mongolian Plateau during the Middle and Late Miocene. Additionally, our results are in agreement with the hypothesis that the central part of Tibet only reached an altitude of less than 2.3 km at approximately 40 Ma. This study highlights that organismal evolution could be related to the formation of the three great Asian plateaus, hence contributing to the knowledge on the timing of the key tectonic events in Asia.
The system of weakly coupled differential equations describing traveling waves in dispersive media is considered.

The Lyapunov — Schmidt construction is used to study the branching of cnoidal-type periodic solutions. The analysis of bifurcation equations uses the group symmetry and cosymmetry of original equations.

Sufficient condition for existence of the phase-shifted modes of cnoidal waves is formulated in terms of the Pontryagin's function determined by the nonlinear perturbation terms
ДВОЙСТВЕННОСТЬ В ЛИНЕЙНЫХ ЭКОНОМИЧЕСКИХМОДЕЛЯХ ОБМЕНА 1 В. И. ШмыревРабота посвящена дальнейшему развитию оригинального подхода к поиску равновесных состояний в линейных экономических моделях обмена.Концептуальной основой подхода является полиэдральная комплементарность, обобщающая известную схему линейной комплементарности.

Исходная проблема сводится к отысканию неподвижных точек кусочно-постоянных многозначных отображений на симплексе цен, порождаемых парой полиэдральных комплексов в двойственности.Для модели с фиксированными бюджетами (модель Фишера) возникающие отображения потенциальны, что позволяет свести проблему равновесия к паре оптимизационных задач, находящихся в двойственности подобно задачам линейного программирования.

Полученное сведение отлично от широко известного результата Гейла Айзенберг и позволяет предложить конечные алгоритмы отыскания равновесных цен.В статье представлена концептуально завершенная версия подхода.Дана точная формулировка двойственного варианта предложенного сведения как для модели Фишера, так и для ее обобщений.Получено сведение и для общей модели с переменными бюджетами
We present energy-momentum mapping of surface Dirac photocurrent in the topological insulator Sb$_2$Te$_3$ by means of time- and angle-resolved two-photon photoemission spectroscopy combined with polarization-variable mid-infrared pulse laser.

It is demonstrated that the direct optical transition from the occupied to the unoccupied part of the surface Dirac-cone permits the linear and circular photogalvanic effect which thereby enables us to coherently control the surface electric-current by laser polarization. Moreover, the surface current mapping directly visualizes ultrafast current dynamics in the Dirac cone in the time domain.

We unravel the ultrafast intraband relaxation dynamics of the inelastic scattering and momentum scattering separately. Our observations pave the pathway for coherent optical control over surface Dirac electrons in topological insulators.
This paper extends our frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. i) Create lifespan Hermitian Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross-spectral tensors were shared. After visual and automatic quality control developmental equations for the mean and standard deviation of qEEG traditional and Hermitian Riemannian descriptive parameters were calculated using additive mixed-effects models. We demonstrate qEEG “batch effects” and provide methods to calculate harmonized z-scores. ii) We also show that the multinational harmonized Hermitian Riemannian norms produce z-scores with increased diagnostic accuracy to predict brain dysfunction at school-age produced by malnutrition only in the first year of life. We provide data and software for constructing norms. iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings. Highlights We create lifespan Hermitian Riemannian qEEG norms for cross-spectral tensors. The norms are based on 9 countries, 12 devices, and 14 studies, with 1564 subjects. We demonstrate qEEG “batch effects”, providing harmonization methods to remove them. Multinational harmonized z-scores increase diagnostic accuracy of brain dysfunction. Data and software are available for norm and individual z-scores calculation.
Cr films of controlled thickness deposited on glass substrates were irradiated by a high number of low-intensity femtosecond laser pulses below the Cr single-pulse damage threshold, producing periodic surface structures (LIPSS) of very high regularity via metal oxidation. To address the multiplicity of electromagnetic modes allowed for thin films, a rigorous numerical approach for modeling surface plasmon polaritons (SPP) in thin-film geometry has been developed. Three types of modes are predicted: the classical SPP with periodicities Λ ~ λ (λ is laser wavelength) at air-film interface, and Λ ~ λ/n at film-substrate interface (n is refractive index of substrate), and a propagation mode Λ ~ λ/nCr where nCr is refractive index of film material. Experimentally observed LIPSS periods match well the predicted modes for the extreme cases, Λ ~ λ/n at film thickness h ≤ 30 nm and Λ ~ λ at h ≥ 200 nm, indicating respectively the dominance of SPP excited at the film-substrate interface and at the metal surface. For 30 nm < h < 200 nm, decreasing of the film thickness results in transition from the pure surface mode to its coupling with and finally domination of the electromagnetic wave excited at the film-substrate interface, providing evidence of the SPP mechanism of LIPSS formation under laser irradiation of thin metallic films.
Breast cancer (BC) is the most common cancer among women. It is known that the prolactin receptor (PRLR) may play a role in breast carcinogenesis, but the available data are often contradictory.

To get a more complete picture of the relationship between the receptor and mammary gland carcinogenesis, we examined the association between changes in PRLR expression level and tumor subtype (and its main characteristics). To do this, using real-time PCR, we evaluated the level of PRLR mRNA in BC tissue samples and untransformed adjoining tissue samples (89 pairs). Since the androgen receptor (AR) has begun to be seen as a prognostic marker in breast cancer, we also evaluated the association between mRNA levels of AR and PRLR.

We found a significant increase in PRLR expression in luminal subtypes; the highest level of PRLR mRNA was detected in luminal A subtype. In HER2-positive ER-, PR-negative BC, the PRLR mRNA level decreases in tumor tissues compared with untransformed tissues. High PRLR expression is also associated with smaller tumor size in luminal B HER2-negative subtype. In ER-, PR-negative tumors, PRLR expression is associated with AR expression: PRLR mRNA level is increased when AR mRNA level is reduced by more than 8 times in triple-negative tumors; in contrast, in HER2-positive subtype it decreases more significantly when AR expression is reduced by more than 3 times. A tendency towards an increase in PRLR expression with an increase in the AR mRNA level was also discovered in luminal subtypes. The level of PRLR expression depends on the age of patients. In luminal A, PRLR expression is higher in patients under 65 years. In contrast, in luminal B HER2-negative and triple-negative BC, reduced PRLR expression was observed in patients under the age of 40 years and under the age of 50 years, respectively. In this group of patients under the age of 40 years with luminal B HER2-negative BC, ER expression was also reduced (0-4 score according to the IHC assay). Thus, PRLR probably plays a different role in the development and progression of BC: in luminal A and luminal B HER2-positive subtypes PRLR may act as an oncogen, and in luminal B HER2-negative and ER-, PR-negative subtypes can play a tumor suppressor role.
The relationship between canine tooth size and social signaling has long been observed in wild carnivore and primate populations. In several of these species, it has been well‐established that larger canine size is directly correlated to social structures where agonistic interactions are commonplace. However, canine teeth are difficult to study in the wild because they serve multiple roles in addition to social signaling, such as food acquisition and guiding functional occlusion of the jaws. The Russian silver fox experiment represents a long‐term, controlled study where foxes have been selected for a behavioral phenotype toward either non‐aggression or hyper‐aggression.

We employed univariate and multivariate comparisons of maxillary canine, maxillary fourth premolar, mandibular first molar mesiodistal length and buccolingual breadth, as well as maximum height and crown height of the canine. These data were collected in sex‐balanced samples of unselected (n=51), tame (n=48), and hyper‐aggressive (n=50) experimental strains.

Results indicate that the canine tooth is the most variable tooth across all three strains. This is in line with observations recorded in wild fox populations. However, foxes in the aggressive‐selected strain exhibit significantly reduced variation in canine crown height compared to the tame and control groups, further supporting hypotheses that the canine is strongly influenced by behavioral selective pressures favoring aggression. The patterns of variability in the tame‐selected strain tend to mirror those in the unselected strain, albeit with greater degrees of sexual dimorphism present in the variation. This provides further evidence that canine teeth are under strong selection relative to behavioral pressures and supports hypotheses that selection on behavior can affect the rate of variability of structures.
Collider searches for dark sectors, new particles interacting only feebly with ordinary matter, have largely focused on identifying signatures of new mediators, leaving much of dark sector structures unexplored. In particular, the existence of dark matter bound states (darkonia) remains to be investigated.

This possibility could arise in a simple model in which a dark photon (A^{'}) is light enough to generate an attractive force between dark fermions. We report herein a search for a J^{PC}=1^{--} darkonium state, the ϒ_{D}, produced in the reaction e^{+}e^{-}→γϒ_{D}, ϒ_{D}→A^{'}A^{'}A^{'}, where the dark photons subsequently decay into pairs of leptons or pions, using 514 fb^{-1} of data collected with the BABAR detector.

No significant signal is observed, and we set bounds on the γ-A^{'} kinetic mixing as a function of the dark sector coupling constant for 0.001
Reference EPFL-ARTICLE-226893doi:10.1007/Jhep02(2017)088View record in Web of Science Record created on 2017-03-27, modified on 2017-05-12
The charge transport mechanism in amorphous oxide semiconductors (AOS) is a matter of controversial debates. Most theoretical studies so far neglected the percolation nature of the phenomenon. In this paper, a recipe for theoretical description of charge transport in AOSs is formulated using the percolation arguments. Comparison with the previous theoretical studies shows a superiority of the percolation approach. The results of the percolation theory are compared to experimental data obtained in various InGaZnO materials revealing parameters of the disorder potential in such AOS.
The nucleolus is a dynamic non-membrane-bound nuclear organelle, which plays key roles not only in ribosome biogenesis but also in many other cellular processes. Consistent with its multiple functions, the nucleolus has been implicated in many human diseases, including cancer and degenerative pathologies of the nervous system and heart.

Here, we report the characterization of the Drosophila Non3 (Novel nucleolar protein 3) gene, which encodes a protein homologous to the human Brix domain-containing Rpf2 that has been shown to control ribosomal RNA (rRNA) processing. We used imprecise P-element excision to generate four new mutant alleles in the Non3 gene. Complementation and phenotypic analyses showed that these Non3 mutations can be arranged in an allelic series that includes both viable and lethal alleles. The strongest lethal allele (Non3∆600) is a genetically null allele that carries a large deletion of the gene and exhibits early lethality when homozygous. Flies heterozygous for Non3∆600 occasionally exhibit a mild reduction in the bristle size, but develop normally and are fertile. However, heteroallelic combinations of viable Non3 mutations (Non3197, Non3310 and Non3259) display a Minute-like phenotype, consisting in delayed development and short and thin bristles, suggesting that they are defective in ribosome biogenesis.

We also demonstrate that the Non3 protein localizes to the nucleolus of larval brain cells and it is required for proper nucleolar localization of Fibrillarin, a protein important for post-translational modification and processing of rRNAs. In summary, we generated a number of genetic and biochemical tools that were exploited for an initial characterization of Non3, and will be instrumental for future functional studies on this gene and its protein product.
Due to possible proliferative effects of karyotypic reorganization of human embryonic stem cell (hESC) lines detailed genetic analysis are indicated prior to any application of hESCs.

Molecular cytogenetic analysis of two different hESC sublines was performed and revealed aberrant chromosomes in both of them, i.e. in hESM01r18 (46,ХХ,-18,+mar) and hESM0309 (46,ХХ,del(4),dup(9)). This study shows that microdissection and multicolor fluorescence in situ hybridization (mFISH) can be used to detect the chromosomal changes precisely of the derivative chromosomes that are difficult to identify by conventional G-banded chromosome analysis. In the present study chromosome microdissection and reverse FISH were applied using multicolor fluorescence in situ hybridization (mFISH) for detailed characterization of the derivative chromosomes.

The karyotypes of hESC lines were described as: 46,ХХ,r(18)(::p11.31→q21.2::q21.2→p11.31::) and 46,XX,del(4)(q25q31.1),dup(9)(q12q33), respectively. The potential role of the chromosomal regions involved in rearrangements for cell proliferation is discussed.
The human immunodeficiency virus (HIV-1) poses a serious risk to global public health. The development of a safe and effective vaccine could stop the HIV/AIDS pandemic. Much of the research focused on HIV-1 prevention through vaccination is aimed at developing immunogens and immunization strategies to induce the formation of antibodies with neutralizing activity against a broad range of HIV-1 isolates (bNAbs).

The objective of this study was to develop immunogens capable of targeting an immune response to MPER, one of the regions of bNAb binding in Env. Two immunogens carrying MPER fragments on their scaffolds (protein YkuJ Bacillus subtilis and artificial polypeptide TBI) were constructed. Circular dichroism spectroscopy was used to show that the secondary structure of the immunogens was consistent with their theoretical models. The antigenic structure of the MPER-TBI and YkuJ-MPER proteins was characterized using bNAbs that recognize HIV-1 MPER (2F5, 4E10, and 10E8). The rabbit model made it possible to show the immunogenicity of the constructed recombinant proteins.

The resulting serum was found to be cross-reactive with immunogens carrying MPER. The constructs designed and characterized in this study can be used for targeting the humoral immune response to MPER, which is known to be one of the sites of HIV-1 vulnerability.
El objetivo del estudio fue desarrollar un mapa físico preliminar de polimorfismos de nucleótido simple (PNSs) en alpaca usando un panel celular híbrido irradiado alpaca/hámster y una micromatriz de genotipado de alta densidad de bovino (BovineHD BeadChip-Illumina).

Se realizó el genotipado de 92 clones celulares híbridos irradiados y cuatro muestras control (alpaca macho, alpaca hembra, hámster y 1:10 alpaca/hámster mezcla de ADN) con la micromatriz. Luego del genotipaje de las muestras control del ADN de alpaca y hámster solo se retuvieron PNSs de bovinos que mostraron una frecuencia de señal positiva de 1. Los PNSs identificados en el ADN de alpaca fueron filtrados para sustraer los presentes en el hámster. De estos últimos, solo se retuvieron para el análisis final aquellos que tuvieron una frecuencia de señal positiva de 0.2 a 0.8 para los 92 clones y se eliminaron los PNSs que presentaron falsos positivos. Los restantes PNSs específicos de alpaca fueron tabulados en el formato MapMaker y fueron analizados con el programa Carthagene para identificar grupos de ligamiento. Los grupos ligados fueron ubicados en el genoma referencial Vicugna_pacos-2.0.2, aplicando el programa BLAST y el comando SHORTBLAST, en la plataforma Galaxy.

Las dos muestras control de alpaca registraron 294 165 PNSs, con señal positiva en la micromatriz de bovino. La cantidad de PNSs de alpaca, después de eliminar los PNSs positivos comunes con hámster, fue 50 686 y luego de eliminar los posibles falsos positivos quedaron 2924 PNSs. Esta cantidad se analizó con el programa Carthagene y resultó en 33 grupos de ligamiento, con un total de 216 PNSs. Las distancias calculadas entre estos PNSs oscilan entre 65.3 y 671.9 cR, con un logaritmo de probabilidades (LOD) >6.0. Finalmente, se encontraron un total de 31 PNSs en el genoma referencial (E-value<0.05).
These objects, with a similar mass and similar decay modes to ${\ensuremath{\pi}}^{0}$ mesons, could provide an explanation for the non-asymptotic behavior of the pion-photon transition form factor observed by the BABAR Collaboration.

We report on a search in ${e}^{+}{e}^{\ensuremath{-}}$ annihilations for new ${\ensuremath{\pi}}^{0}$-like particles produced in association with a $\ensuremath{\tau}$-lepton pair.

No significant signal is observed, and limits on the production cross section at the level of 73 fb or 370 fb, depending on the model parameters, are determined at 90% confidence level. These upper limits lie below the cross section values needed to explain the BABAR form factor data.