Hengzongshu/ArticleAgent huggingface dataset:
Background External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development and comparative model validation and to make projections for population risk stratification. Methods Performance of two recently developed models, one based on the Breast and Prostate Cancer Cohort Consortium analysis (iCARE-BPC3) and another based on a literature review (iCARE-Lit), were compared with two established models (Breast Cancer Risk Assessment Tool and International Breast Cancer Intervention Study Model) based on classical risk factors in a UK-based cohort of 64 874 white non-Hispanic women (863 patients) age 35–74 years. Risk projections in a target population of US white non-Hispanic women age 50–70 years assessed potential improvements in risk stratification by adding mammographic breast density (MD) and polygenic risk score (PRS). Results The best calibrated models were iCARE-Lit (expected to observed number of cases [E/O] = 0.98, 95% confidence interval [CI] = 0.87 to 1.11) for women younger than 50 years, and iCARE-BPC3 (E/O = 1.00, 95% CI = 0.93 to 1.09) for women 50 years or older. Risk projections using iCARE-BPC3 indicated classical risk factors can identify approximately 500 000 women at moderate to high risk (&gt;3% 5-year risk) in the target population. Addition of MD and a 313-variant PRS is expected to increase this number to approximately 3.5 million women, and among them, approximately 153 000 are expected to develop invasive breast cancer within 5 years. Conclusions iCARE models based on classical risk factors perform similarly to or better than BCRAT or IBIS in white non-Hispanic women. Addition of MD and PRS can lead to substantial improvements in risk stratification. However, these integrated models require independent prospective validation before broad clinical applications.
The BNCT-drugs (BSH and BPA) toxicity for 8-10-week-old severe combined immunodeficiency (SCID) male mice outbred with SPF-status was studied.

The possibility of increasing BPA (L-p-boron phenylalanine) and BSH (sodium salt of borocaptate) therapeutic dose was shown. The relationship between a safe therapeutic dose and the administration method of BPA was found. The intraperitoneal injection allows one to increase the dose of BPA at least twice -700 mg/kg b.w, BSH -at least 8 times, 800 mg/kg b.w with intraperitoneal injections.

The BPA intraperitoneal and intratumoral injections demonstrate higher results in comparison with intravenous administration. The highest and statistically significant concentration of 10 В in the tumor was found for intraperitoneal injection of BPA for intratumoral injection of BPA -27±5 μg/g (heterotopic tumors, P=0.95). The highest tumor/blood ratio for BPA was 7.5 for intratumoral administration in the point of 1h (heterotopic tumors). The maximum concentration of 10 В with the introduction of BSH was with intravenous administration and was 8±3 μg/g (orthotopic tumors). The highest tumor/blood ratio was 9.5 for intravenous injection in 1h point (heterotopic tumors).
Although antioxidants have been repeatedly tested in animal models and clinical studies, there is no evidence that antioxidants reduce already developed age-related decline. Recently we demonstrated that mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) delayed some manifestations of aging.

Here we compared effects of SkQ1 and N-acetyl-L-cysteine (NAC) on age-dependent decline in blood levels of leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1), testosterone, dehydroepiandrosterone (DHEA) in Wistar and senescence-accelerated OXYS rats.

When started late in life, supplementation with SkQ1 not only prevented age-related decline but also significantly reversed it. With NAC, all the observed effects were of the lower magnitude compared with SkQ1 (in spite of that dose of NAC was 16000 times higher). We suggest that supplementation with low doses of SkQ1 is a promising intervention to achieve a healthy ageing.
Nonlinear interactions between different components of multiwavelength radiation are one of the main processes shaping properties of quasi-CW fiber lasers. In random fiber lasers, nonlinear influence may be more complicated, as there are no distinct longitudinal modes in radiation because of the random nature of the feedback. In this Letter, we experimentally characterize internal correlations in the radiation of a multiwavelength random distributed feedback fiber laser. An analysis of Pearson correlation functions allows us to spatially locate the area over the fiber laser length in which correlations are more likely to occur. This, in turn, leads us to the conclusion about the main mechanism of spectral correlations-the relative intensity noise transfer from the pump wave.
On the basis of researches on examination of gas hydrates previously made in Kutateladze Institute of Thermophysics SB RAS the new method was developed. That method is based on cyclic boiling-condensation process of gas-hydrating agent in enclosed volume. This method compares favorably with previously developed ones by its simplicity. There is no need in constant gas supply and mixing device.
The paper summarizes the results of experiments on electron cyclotron emission (ECE) measurements recently performed at the GDT magnetic mirror device. The new ECE diagnostics is installed to facilitate the successful ECRH experiment and operates in the vicinity of the ECRH frequency 54.5 GHz. The particulars of plasma emission at the fundamental electron cyclotron harmonic are studied experimentally in a broad range of discharge scenarios.
The article presents a comparison of the Agent-Based Multiregional Input–Output Model (ABMIOM) of the Russian economy and a small-size version of the Optimization Multiregional Input-Output Model (OMIOM) from the per-spective of their possible integration for spatial economic research. These models share many similar features, technically and conceptually. The two models regard the economy as a complex system of interdependent compo-nents; both have the same spatial and sectoral structure, similar production technologies. Both allow to perform a structural analysis of processes taking place in the economy in terms of industries and territories. The former is a simulation model, the latter is a linear optimization model; their major differ-ences relate to the methods of modeling the market and price mechanisms and of representing the space. We propose to use a spatial input-output model based on the real data as the source of disaggregated information at the stage of initialization of agent-based models, which opens opportunities of gradual turning them into an experimentation area for the real economy, rather than an instrument for an analysis of an artificial economy.
Resonant acoustic mixing (RAM) is a new technology designed for intensive mixing of powders that offers the capability to process powders with minimal damage to particles. This feature is particularly important for mixing impact-sensitive materials such as explosives and propellants. While the RAM technique has been extensively employed for the mixing of powders and viscous polymers, comparatively little is known about its use for mechanosynthesis.

We present here the first in situ study of RAM-induced co-crystallisation monitored using synchrotron X-ray powder diffraction. The phase profile of the reaction between nicotinamide and carbamazepine in the presence of a small amount of water was monitored at two different relative accelerations of the mixer.

In marked contrast to ball-milling techniques, the lack of milling bodies in the RAM experiment does not hinder co-crystallisation of the two starting materials, which occurred readily and was independent of the frequency of oscillation. The reaction could be optimised by enhancing the number of reactive contacts through mixing and comminution. These observations provide new insight into the role of various experimental parameters in conventional mechanochemistry using liquid-assisted grinding techniques.
The oxidation process of samariumoxysulfide was studied in the temperature range of 500–1000 °C. Our DTA investigation allowed for establishing the main thermodynamic (∆Hºexp = −654.6 kJ/mol) and kinetic characteristics of the process (Ea = 244 kJ/mol, A = 2 × 1010). The enthalpy value of samarium oxysulfate (ΔHºf (Sm2O2SO4(monocl)) = −2294.0 kJ/mol) formation was calculated. The calculated process enthalpy value coincides with the value determined in the experiment. It was established that samarium oxysulfate crystallizes in the monoclinic symmetry class and its crystal structure belongs to space group C2/c with unit cell parameters a = 13.7442 (2), b = 4.20178 (4) and c = 8.16711 (8)Å, β = 107.224 (1)°, V = 450.498 (9)Å3, Z = 4. The main elements of the crystalline structure are obtained and the cation coordination environment is analyzed in detail. Vibrational spectroscopy methods confirmed the structural model adequacy. The Sm2O2SO4luminescence spectra exhibit three main bands easily assignable to the transitions from 4G5/2 state to 6H5/2, 6H7/2, and 6H9/2 multiplets.
Systemic lupus erythematosus (SLE) is an inflammatory disease. The sera of SLE patients contain antibodies-abzymes hydrolyzing myelin basic protein (MBP), DNA, nucleotides, and oligosaccharides. The blood of SLE patients contains an increased amount of some specific miRNAs. This study aimed to analyze a possible hydrolysis of eight microRNAs found in the blood of SLE patients with high frequency by blood antibodies-abzymes.Using affinity chromatography of the serum proteins of SLE patients and healthy donors on protein G-Sepharose and following FPLC gel filtration, electrophoretically homogeneous IgG preparations containing no impurities of canonical RNases were obtained. These preparations were used to analyze their activity in the hydrolysis of eight miRNAs.It was shown that SLE IgGs hydrolyze very efficiently four neuroregulatory miRNAs (miR-219-2-3p, miR-137, miR-219a-5p, and miR-9-5p) and four immunoregulatory miRNAs (miR-326, miR-21-3p, miR-155-5p, and miR-146a-3p). To demonstrate that the miRNAs hydrolysis is an intrinsic property of SLE IgGs, several rigid criteria were checked. Only some IgGs of healthy donors showed very weak, but reliably detectable activity in the hydrolysis miRNAs. The average activity of SLE patients IgGs according to median values is statistically significant 84.8-fold higher than that of healthy donors. The maximum and comparable average activity (RA) was observed in the hydrolysis of three miRAs: miR-9-5p, miR-155-5p, and miR-326. MiR-9-5p plays an important role in the development of lupus nephritis, while miR-326 activates the production of antibodies by B cells. The major and moderate specific sites of the hydrolysis of each miRNA were revealed. The hydrolysis of eight microRNAs was mostly site specific. Several SLE IgGs hydrolyzed some miRNAs demonstrating a combination of site-specific and non-specific splitting.Since inflammatory processes in SLE are associated with the change in miRNAs expression, the decrease in their concentration due to hydrolysis by autoantibodies-abzymes may be important for SLE pathogenesis.
The Forced Invariance Method (FIM) is a vegetation suppression algorithm for multispectral images which is of great interest since it uses statistics collected only from the pixels of the image itself. Due to this a priori spectral characteristics of the captured objects are not required. For using the FIM or its modification in practice it is necessary to have some way to evaluate algorithm efficiency in order to analyze the results of experiments. This paper presents the method designed to solve this problem. Presumably, it is suitable for evaluating various algorithms, such as those designed to suppress vegetation. The proposed method is based on the idea of comparing a processed image with its standard using the similarity measure.
A large amount of data collected with the CMD-3 detector above the threshold of the nn ̅pair allows to measure the cross section of the process e + e − → nn ̅and the neutron form factor with good accuracy. This task is complicated by a large number of background events and necessity of finding ways to suppress them. A technique of identification for e + e − → nn ̅events is described.
Energy of chirped dissipative solitons (DS) generated in fiber lasers may exceed a threshold of stimulated Raman scattering (SRS) leading to formation of a noisy Raman pulse (RP). As we demonstrated recently, a feedback loop providing re-injection of the Raman pulse into the laser cavity can form a Raman dissipative soliton (RDS) with similar characteristics to those of the main dissipative soliton.

Here, we present the results of feedback optimization of the generated RDS spectra.

First experimental results of coherent combining of DS and RDS are also shown.
Currently, the economy should develop along an innovative way of development with an increase in the efficiency of the use of natural resources and a decrease in negative impacts on the environment to ensure stable economic growth and improve the quality of life of the population. The purpose of the study is to assess the environmental and energy effects that affect the environment and energy intensity in the country. The dynamics of greenhouse gas emissions in Russia are contemporaneously influenced by many different factors, such as the industry structure of the economy, the structure of the fuel and energy balance, the level of technological equipment, and the situation in world markets. Our analysis showed that the dynamics of CO2 emissions in Russia are determined primarily by the growth rates of the population’s well-being and by the growth of industrial production. At the same time, in the period 2000-2012, the effect of welfare growth was partially offset by a decrease in the energy intensity of the economy, but then the potential for reducing energy intensity due to changes in the structure of the economy was exhausted. The contribution of the technological factor is also insufficient. So for the period 2000-2017, the improvement of technologies in the field of heat and electric energy production from fossil energy sources made it possible to reduce CO2 emissions by only 33 million tons. Another significant constraint to the transition to a low-carbon trajectory of development is the low rate of implementation of energy-saving technologies in the production of energy-intensive industrial products, maintenance of residential and public buildings.
Study of the levels of climatic comfort in localities of the rare species Calvatia gigantea from Agaricales of Basidiomycota is performed using multimodal ecoinformative approach with maximum entropy method.

For numerically exact and correct assessment of the level of climate suitability, we propose recalculate the scale of probalility finding of a species into a new scale of climate suitability, with the next intervals: low suitable (1–3 points), ambivalent (4–6 points), and genuine suitable (7–9 points). Also there are two transit zones between these intervals.

It has been astablished that local populations of the species in Altai territorial group differ significantly in levels of climatic comfort (3.2, 5.4, and 6.2 points). Local population near Sharangol in Khentei territorial cluster (Central Mongolia) gets 4.0 points of climate comfort, and local population in Khingan Mountains (Eastern Mongolia) gets 7.3 points, the best result in the set studied. The ecotypification of localities was carried out, according to which all the studied populations of C. gigantea are assigned to different ecotypes, since each studied locality is characterized by the unique climatic spectrum and the specific variable of the first rank.
Natural bio-nanocomposites (rice husk, sapropel, peat and brown coal) have been studied by TEM, XRD and SAXS. Particle size distributions for the mineral matter in these systems were determined by SAXS with using full contrast technique. In the rice husk silica nanoparticles are forming compact particles with bimodal distribution and mean size is equal 4.7 nm. In the case of peat and brown coal mineral matter in organic matrix are forming more large particles with compact shapes and mean sizes 14.1 nm and 14.3 nm respectively. In the sapropel inorganic matter are forming elongated structures with lengths are equal 20-70 nm and widths are equal 2-10 nm.
Transcription factors (TFs) are main regulators of eukaryotic gene expression. The cooperative binding to genomic DNA of at least two TFs is the widespread mechanism of transcription regulation. Cooperating TFs can be revealed through the analysis of co-occurrence of their motifs.

We applied the motifs co-occurrence tool (MCOT) that predicted pairs of spaced or overlapped motifs (composite elements, CEs) for a single ChIP-seq dataset. We improved MCOT capability for the prediction of asymmetric CEs with one of the participating motifs possessing higher conservation than another does.

Analysis of 119 ChIP-seq datasets for 45 human TFs revealed that almost for all families of TFs the co-occurrence with an overlap between motifs of target TFs and more conserved partner motifs was significantly higher than that for less conserved partner motifs. The asymmetry toward partner TFs was the most clear for partner motifs of TFs from the ETS (E26 Transformation Specific) family. Co-occurrence with an overlap of less conserved motif of a target TF and more conserved motifs of partner TFs explained a substantial portion of ChIP-seq data lacking conserved motifs of target TFs. Among other TF families, conservative motifs of TFs from ETS family were the most prone to mediate interaction of target TFs with its weak motifs in ChIP-seq.
parahydrogen-enhanced NMR and MRI, which are free from the limitations of high-field magnetic resonance (including susceptibility-induced gradients of the static magnetic field at phase interfaces)

By using 5.75 and 47.5 mT nuclear magnetic resonance (NMR) spectroscopy, up to 10 5‐fold sensitivity enhancement through signal amplification by reversible exchange (SABRE) was enabled, and subsecond temporal resolution was used to monitor an exchange reaction that resulted in the buildup and decay of hyperpolarized species after parahydrogen bubbling. We demonstrated the high‐resolution low‐field proton magnetic resonance imaging (MRI) of pyridine in a 47.5 mT magnetic field endowed by SABRE. Molecular imaging (i.e. imaging of dilute hyperpolarized substances rather than the bulk medium) was conducted in two regimes: in situ real‐time MRI of the reaction mixture (in which pyridine was hyperpolarized), and ex situ MRI (in which hyperpolarization decays) of the liquid hyperpolarized product.

Low‐field (milli‐Tesla range, e.g. 5.75 and 47.5 mT used in this study) parahydrogen‐enhanced NMR and MRI potentially enables new imaging applications as well as differentiation of hyperpolarized chemical species on demand by exploiting spin manipulations with static and alternating magnetic fields.
BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important for ensuring early detection of individuals at increased risk of future fractures and taking preventive measures. AIMS: To determine the frequency of a history of forearm fractures in patients with type 2 diabetes mellitus (DM2) and without diabetes, and their association with risk factors for chronic non-communicable diseases (NCD). MATERIAL AND METHODS: In 20152017, in Novosibirsk, a random urban population sample of males and females, 5884 years old (n=3878), was surveyed. The study included persons who signed the informed consent to conduct the study, excluded individuals who wrote a waiver of taking blood to determine biochemical parameters. In total, the analysis included n=3393 people, 718 of them with DM2 (21.2%). Work design is cross-sectional research. The collection of information on fractures during for the last 3 years, the registration of socio-demographic data; and risk factors for NCD, a study of biochemical blood parameters. The analysis of the association of DM2 and a complex of risk factors for NCD with a chance of a forearm fracture. RESULTS: The prevalence of forearm fractures in the last 3 years did not differ in patients with DM2 compared with those examined without diabetes and was 2.4% and 2.8%, respectively (p=0.557). Men with fractures had higher cholesterol and HDL values, women had lower body mass index (BMI), compared with people without fractures. According to the results of a multivariate analysis in women, the chance of a forearm fracture is directly associated with smoking in the past, a total cholesterol level of more than 200 mg/dl and inversely associated with a BMI. In men, associations were found of the chance of a forearm fracture with an increase in the level of cholesterol. There was no evidence of DM2 with forearm fracture. CONCLUSION: The obtained data on the incidence of fractures and their association with risk factors for chronic low risk infections suggest the need for preventive measures for osteoporotic fractures, both in people with and without DM2.
Remarkable mathematical properties of the integrable nonlinear Schrödinger equation (NLSE) can offer advanced solutions for the mitigation of nonlinear signal distortions in optical fiber links. Fundamental optical soliton, continuous, and discrete eigenvalues of the nonlinear spectrum have already been considered for the transmission of information in fiber-optic channels. Here, we propose to apply signal modulation to the kernel of the Gelfand-Levitan-Marchenko equations that offers the advantage of a relatively simple decoder design. First, we describe an approach based on exploiting the general N-soliton solution of the NLSE for simultaneous coding of N symbols involving 4×N coding parameters. As a specific elegant subclass of the general schemes, we introduce a soliton orthogonal frequency division multiplexing (SOFDM) method. This method is based on the choice of identical imaginary parts of the N-soliton solution eigenvalues, corresponding to equidistant soliton frequencies, making it similar to the conventional OFDM scheme, thus, allowing for the use of the efficient fast Fourier transform algorithm to recover the data. Then, we demonstrate how to use this new approach to control signal parameters in the case of the continuous spectrum.Received 10 March 2017DOI:https://doi.org/10.1103/PhysRevLett.118.223901© 2017 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasCommunication schemesMathematical physicsPhysical SystemsNonlinear wavesSolitonsNonlinear DynamicsInterdisciplinary Physics
Aim . To investigate links between the attachment style and ability to detect facial emotions using a functional magnetic resonance imaging (fMRI) paradigm in depressed patients. Materials and methods . Participants diagnosed with mild to moderate depression or dysthymia (19 patients) and healthy volunteers (20 individuals) were to identify one of eight basic emotions on 48 photos by choosing the appropriate answer from two options. Attachment was measured using the Experience in Close Relationships Scale. In addition, depression, alexithymia, and rumination were estimated as other possible correlates. Results. In the group of patients with depression, anxious attachment score had a negative correlation with the accuracy of angry facial expression detection (ρ = –0.65, p < 0.01) and a positive correlation with the accuracy of sad facial expression recognition (ρ = 0.48, p < 0.05). Patients with high total rumination (ρ = –0.48, p < 0.05) and depressive rumination (ρ = –0.53, p < 0.05) scores also detected angry facial expression less accurately. None of the mentioned links were present in healthy people, however, they demonstrated a correlation of the total number of portraits tagged as “sad” with the brooding rumination score (ρ =0 .53, p < 0.05). Conclusion . Attachment disruptions in depressed patients may be related to aggravation of the deficit in the ability to detect emotions of others.