Hengzongshu/ArticleAgent huggingface dataset:
Russian Sign Language is a natural language that serves as a means of communication for people with hearing impairments. Currently, it is necessary to provide communication paths between hearing and deaf people, which requires the solution of several specific problems, one of which is gesture recognition.

The paper presents a system for recognizing isolated static and dynamic gestures of the dactyl alphabet of the Russian Sign Language. The system is based on machine learning methods and is an LSTM with Mediapipe Hands as feature extractor.

The network showed an F-measure value of 91% on test data.
Purpose. The article analyzes items of the Buryats’ archery complex depicted on the postcards of the early 20th century. These are bows and arrows, quivers, bow cases, belts and one arrow storage. Also in the article, the history of photographs are examined, the authorship and dating of the photographs are found. Results. In total, four postcards with east Buryats and three postcards with west Buryats were found. The analysis showed that all the images have bows with similar geometrical features that tells us about the proximity of structures. Items similar in geometry are now kept in museums and private collections and belong to the Buryat traditional culture and differ from the Manchu tradition bows, popular among the peoples of South Siberia and Central Asia. All the Buryat quivers have a special shape and are called “humpbacked” in publications. The bow cases are shaped like half a bow. Quivers and bow cases are represented in two decorative traditions: western and eastern. In western tradition, usually the entire front surface of quivers and bow cases is covered with metal plates of various shapes. The edges were decorated with sub-rectangular plates using vajra and “ram’s horn symbols”. The central part of the bow cases was filled with discs, the same part of the quivers contains a disk and a ‘comet’. Eastern tradition shows the use of metal plates much less frequently. One image shows a quiver similar in design to Mongolian items, however, in shape resembling Buryat “humpbacked” quivers. One image shows an arrow storage – a case for storing arrows. The images also show the features of wearing and using items of the archery complex. Conclusion. The postcard images confirm previous conclusions about the uniqueness of the Buryat archery complex and make it possible to highlight new typical features. All of this tells us about the importance of referring to visual sources including postcards when studying weapons.
A series of 2'-deoxy and novel 2'-O-methyl and 2'-O-(2-methoxyethyl) (2'-MOE) oligonucleotides with internucleotide methanesulfonyl (mesyl, μ) or 1-butanesulfonyl (busyl, β) phosphoramidate groups has been synthesized for evaluation as potential splice-switching oligonucleotides. Evaluation of their splice-switching activity in spinal muscular atrophy patient-derived fibroblasts revealed no significant difference in splice-switching efficacy between 2'-MOE mesyl oligonucleotide and the corresponding phosphorothioate (nusinersen). Yet, a survival study with model neonatal mice has shown the antisense 2'-MOE mesyl oligonucleotide to be inferior to nusinersen at the highest dose of 40 mg/kg. A reason for their lower activity in vivo as ascertained by cellular uptake study by fluorescent confocal microscopy in HEK293 cell line could possibly be ascribed to compromised endosomal release and/or nuclear uptake of the 2'-OMe or 2'-MOE μ- and β-oligonucleotides compared to their phosphorothioate analog.
In this paper, we report a spectroscopic study of natural type Ib-IaA diamonds containing Y centers subjected to high-pressure high-temperature treatment at 7–7.5 GPa and 1700–2200 °C. Diamond samples showing the Y centers as the dominant absorption feature in the infrared spectra were selected from a collection of natural diamonds from alluvial placers of the northeastern Siberian Platform. The samples were investigated by spectroscopic techniques before and after each annealing stage. It was found that upon annealing at temperatures higher than 2000°C, the defect-induced one-phonon spectra changed from the Y centers to a new form with a characteristic band peaking at 1060 cm−1. Photoluminescence spectra of the samples were modified after each annealing stage starting from 1700 °C. The most significant changes in photoluminescence occurred at temperatures higher than 2000 °C and were associated with a sharp increase of the intensity of an emission band peaking at about 690 nm. A comparison with natural red-luminescing diamonds from Yakutian kimberlite pipes was performed. It was concluded that the observed 1060 cm−1 IR band and the 690 nm red emission band are genetically related to the Y centers and that defects or impurities responsible for the Y centers appear quite widespread in natural diamonds from various deposits worldwide.
The step-by-step Hi-C protocol is described for mosquito embryos at the 15-18 h developmental stage. In brief, we collect mosquito eggs, fix them with 3% formaldehyde, and prepare Hi-C libraries using nuclei isolated from ~1000-3000 embryos of mixed sexes. We use MboI restriction enzyme and T4-ligase to generate two biological replicates per species. Libraries can be prepared with NEBNext® Ultra™ II DNA Library Prep Kit for Illumina. The protocol was adapted for Anopheles species and successfully verified for Culex and Aedes embryos.
By using the Gold map

we construct a partition of the hypercube into cosets of Hamming codes

such that for every two cosets the corresponding Hamming codes are maximally nonparallel, that is, their intersection cardinality is as small as possible to admit nonintersecting cosets
This paper is a survey of some results about the structure of periodic groups saturated with finite simple groups of Lie type.It is based on a talk of authors given on the XI workshop on Group theory dedicated to the 70-th anniversary of A.
The photoexcitation of (multi-electron) atoms and ions by twisted light has been explored within the framework of the density matrix theory and Dirac's relativistic equation. It is shown that the population of the excited atoms and, hence, their fluorescence emission are sensitive with regard to the transverse linear momentum and the (projection of the) total angular momentum of the incident light.
To analyse the mechanism of Sheuermann’s disease genetic determination in a representative samples of pedigrees and to identify its hereditary phenotypic signs.

Patients with Scheuermann’s disease (90 probands and 385 relatives of 1st–3rd relation degree) were examined using clinical-genetical, optical topographical, and radiological methods.

Segregation analysis has shown that Scheuermann’s disease is a genetically dependent pathology inherited by autosomal dominant type and controlled by major gene with full pentrance in boys and 50 % penetrance in girls.
Surface- and tip-enhanced resonant Raman scattering (resonant SERS and TERS) by optical phonons in a monolayer of CdSe quantum dots (QDs) is demonstrated. The SERS enhancement was achieved by employing plasmonically active substrates consisting of gold arrays with varying nanocluster diameters prepared by electron-beam lithography. The magnitude of the SERS enhancement depends on the localized surface plasmon resonance (LSPR) energy, which is determined by the structural parameters. The LSPR positions as a function of nanocluster diameter were experimentally determined from spectroscopic micro-ellipsometry, and compared to numerical simulations showing good qualitative agreement. The monolayer of CdSe QDs was deposited by the Langmuir-Blodgett-based technique on the SERS substrates. By tuning the excitation energy close to the band gap of the CdSe QDs and to the LSPR energy, resonant SERS by longitudinal optical (LO) phonons of CdSe QDs was realized. A SERS enhancement factor of 2 × 10(3) was achieved. This allowed the detection of higher order LO modes of CdSe QDs, evidencing the high crystalline quality of QDs. The dependence of LO phonon mode intensity on the size of Au nanoclusters reveals a resonant character, suggesting that the electromagnetic mechanism of the SERS enhancement is dominant. Finally, the resonant TERS spectrum from CdSe QDs was obtained using electrochemically etched gold tips providing an enhancement on the order of 10(4). This is an important step towards the detection of the phonon spectrum from a single QD.
The article presents the adaptation results for “Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT)” questionnaire for early diagnosis of autism spectrum disorders (ASD) in the Russian-speaking sample (n=105). We evaluated the psychometric properties of the Russian version questionnaire: internal consistency reliability, construct validity, criterion-related validity and item discrimination. According to the results of the adaptation, BISCUIT questionnaire has good psychometric indicators, however, cutoff scores should be revised on a standardization sample with a larger number of clinical cases.
We described all δ-derivations of semisimple f.-d. structurable algebras over algebraically closed field with characteritic is not equal 2,3,5.
The review presents current data on the Arterial Hypertension (AH) and Gallstone Disease (GSD) prevalence. The heterogeneity of the relationship between cardiovascular diseases, AH and GSD was shown.

According to our data, in Novosibirsk, in the population sample of women 25-64 years with/without GSD (n=870) prevalence of AH (criteria blood pressure (BP) >160/95, WHO MONICA project, 1994-1995) was 41,6% and 31,3%, p<0,05. In this female population as a whole (n=1663) prevalence of AH was 30,8%. But with the criteria of BP >140/90, the corresponding indicators of prevalence of AH were similar: 55,4%, 47,1% and 49,0%. Gastroenterological symptoms, BP, blood lipids, quality of life were compared, which were worse in comorbid patients with GSD and AH than in GSD or AH.

The evidence of the association between the GSD and the carotid arteries intima-media thickness, as atherosclerosis marker, is presented, and the main mechanisms of development of AH in GSD are highlighted. The expediency of an active approach to the detection of GSD and AH in terms of their contribution to cardiovascular prognosis is shown.
For the first time, rupture event scanning (REVS) procedure based on quartz crystal microbalance (QCM) and involving only mechanical action was used to determine the height of the energy barrier for dsDNA unwinding. Melting point was determined with the help of this procedure. To determine the thermodynamic parameters including enthalpy, DNA denaturation was represented as a unimolecular process. This allowed us to recover the energy profiles from the experimental data obtained by force measurements at different scanning times (reaction times) for different temperatures. The thus obtained results were compared with the data obtained with the help of another mechanical method, namely, atomic force microscopy. The mechanism of DNA unwinding in QCM-based experiments through the unzipping mode, as proposed by us in previous works, was confirmed. Thus, we demonstrated that REVS procedure may be used to assess the thermodynamic parameters of dsDNA unwinding.
The article describes one of the important directions of increasing the level of innovative development of the oil and gas complex of Russia - the development of hard-to-recover hydrocarbon reserves (HTR).

The authors estimated the share of HTR in modern oil production, analyzed the dynamics and structure of hydrocarbons of special quality and conditions.

The search, exploration and development of hard-to-recover reserves can bring the domestic oil and gas and related industries to a new level of technological development, provide a significant multiplier effect for related industries, and create new jobs and infrastructure.
Aim . To study the dynamics of obesity phenotypes and risk of myocardial infarction (MI) during 13-year follow-up period.

Material and methods . The study was performed based on the material of the international project HAPIEE (population sample of men and women 45-69 years old, n=9360, basic survey 2003-2005). The analysis included persons with a body mass index (BMI) >30 kg/m2: 3197 people; 857 men (26,8%) and 2340 women (73,2%). To analyze the incidence of MI, a sample of 3008 subjects free from baseline history of MI was selected (752 men and 2256 women). New cases of myocardial infarction have been collected according to the data of the WHO 'Register of Acute Myocardial Infarction' program, held at the Research Institute of Therapy and Preventive Medicine; the results of two repeated examinations (2006-2008 and 2015-2017) and repeated postal interview of cohort during 13-year follow-up. The analysis was carried out in individuals with a metabolically phenotype of healthy obesity (MHO). The MHO is defined according to various classifications: NCEPATPIII 2001 — in the presence of 2 and/or less components of the metabolic syndrome; IDF 2005 — waist circumference (WC) >94 cm in men and >80 cm in women and one or no risk factor; Russian Society of Cardiology (RSC) — the index of waist circumference/hip circumference (WC/HC) 0,05.

Conclusion . MHO is unstable condition accompanied by transition to the MUH among more than half of men and women during 13 years of observation. In studied population cohort the 13-years risk of incident MI in subjects with MUO was higher compared to MHO: OR=1,9 (95% CI: 1,2; 2,9) by NCEPATP III; OR=3,2 (95% CI: 1,7; 6,1) by RSC criteria.
Huntington’s disease (HD) is a severe neurodegenerative disorder caused by a CAG triplet expansion in the first exon of the HTT gene. Here we report the introduction of an HD mutation into the genome of healthy human embryonic fibroblasts through CRISPR/Cas9-mediated homologous recombination. We verified the specificity of the created HTT-editing system and confirmed the absence of undesirable genomic modifications at off-target sites. We showed that both mutant and control isogenic induced pluripotent stem cells (iPSCs) derived by reprogramming of the fibroblast clones can be differentiated into striatal medium spiny neurons. We next demonstrated phenotypic abnormalities in the mutant iPSC-derived neural cells, including impaired neural rosette formation and increased sensitivity to growth factor withdrawal. Moreover, using electron microscopic analysis, we detected a series of ultrastructural defects in the mutant neurons, which did not contain huntingtin aggregates, suggesting that these defects appear early in HD development. Thus, our study describes creation of a new isogenic iPSC-based cell system that models HD and recapitulates HD-specific disturbances in the mutant cells, including some ultrastructural features implemented for the first time.
A sample of $114\ifmmode\pm\else\textpm\fi{}11$ ${B}_{s}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ signal events obtained with $0.37\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of $pp$ collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ collected by the LHCb experiment is used to measure the branching fraction and polarization amplitudes of the ${B}_{s}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\overline{K}}^{*0}$ decay, with ${\overline{K}}^{*0}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$. The ${K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ mass spectrum of the candidates in the ${B}_{s}^{0}$ peak is dominated by the ${\overline{K}}^{*0}$ contribution. Subtracting the nonresonant ${K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ component, the branching fraction of ${B}_{s}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\overline{K}}^{*0}$ is $({4.4}_{\ensuremath{-}0.4}^{+0.5}\ifmmode\pm\else\textpm\fi{}0.8)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$, where the first uncertainty is statistical and the second is systematic. A fit to the angular distribution of the decay products yields the ${K}^{*0}$ polarization fractions ${f}_{L}=0.50\ifmmode\pm\else\textpm\fi{}0.08\ifmmode\pm\else\textpm\fi{}0.02$ and ${f}_{\ensuremath{\parallel}}={0.19}_{\ensuremath{-}0.08}^{+0.10}\ifmmode\pm\else\textpm\fi{}0.02$.
The segregation is caused by the displacement of dissolved gas by moving plane crystallization front.

Analytical solution of the segregation problem was found for the arbitrary crystal growth law using the quasi-steady-state approximation. The effect of solidification shrinkage on the crystallization process was taken into account.

It is shown that in the case of 'equilibrium crystallization' (when the growth rate is in inverse ratio to time) the solution of the problem becomes self-similar. In this case gas concentration at the crystallization front stays the same during the whole process while the diffusion layer thickness increases with time.
The importance of the biological properties of proteins to cells cause actively exploring their amino acid composition (primary structure). The versatile tool of cell proteome exploring is mass-spectroscopy. The interpretation of massspectroscopy data is complex challenge because it remains uncertain peptide dissociation mechanisms and external factor influence to peptide fragmentation process.

Moreover, a lot of mass-spectroscopy data is required to enhancement existing or development novel algorithms to interpret peptide mass-spectra. The article describes development of algorithm for in silico generation peptide mass-spectra covered the problem of influence noncanonical amino acid composition and posttranslational modifications to dissociation process.

Developed algorithm was compared with analogues and evaluated over experimental data.
Many models of physics beyond the Standard Model predict the existence of new Abelian forces with new gauge bosons mediating interactions between "dark sectors" and the Standard Model.

We report a search for a dark boson Z' coupling only to the second and third generations of leptons in the reaction e+e- -> mu+mu- Z', Z' -> mu+mu- using 514 fb-1 of data collected by the BABAR experiment.

No significant signal is observed for Z' masses in the range 0.212 - 10 GeV. Limits on the coupling parameter g' as low as 7x10^-4 are derived, leading to improvements in the bounds compared to those previously derived from neutrino experiments.
Macrogeographic patterns of polytene chromosomal banding sequences were studied in natural populations of the Holarctic species Chironomus plumosus. Of the 31 inversion sequences now known, 16 are endemic to the Palearctic, 7 are endemic to the Nearctic, and 8 are Holarctic sequences common to both zoogeographic zones.

Differences in the sets of inversion sequences found on each continent, plus differing frequencies of Holarctic sequences, result in great overall divergence of karyotypes on the two continents. The karyotype of Nearctic C. plumosus differs from that of Palearctic populations primarily by the presence of a homozygous Nearctic sequence in arm A (n'plu A9), along with fixation (h'plu C2, h'plu E2, and h'plu F1), or high frequency (h'plu D2), of Holarctic sequences which are present but less frequent in the Palearctic.

Although long continental isolation has led to great divergence of karyotypes on opposite sides of the Atlantic Ocean, all populations of C. plumosus show sufficient cytogenetic similarity to constitute a single Holarctic species.
Here, we report a simple and effective method to remove IrIMes homogeneous polarization transfer catalysts from solutions where NMR signal amplification by reversible exchange (SABRE) has been performed, while leaving intact the substrate's hyperpolarized state. Following microtesla SABRE hyperpolarization of 15N spins in metronidazole, addition of SiO2 microparticles functionalized with 3-mercaptopropyl or 2-mercaptoethyl ethyl sulfide moieties provides removal of the catalyst from solution well within the hyperpolarization decay time at 0.3 T (T1 > 3 min) and enabling transfer to 9.4 T for detection of enhanced 15N signals in the absence of catalyst within the NMR detection region. Successful catalyst removal from solution is supported by the inability to "rehyperpolarize" 15N spins in subsequent attempts, as well as by 1H NMR and inductively coupled plasma mass spectrometry. Record-high 15N nuclear polarization of up to ∼34% was achieved, corresponding to >100 000-fold enhancement at 9.4 T (or >320,000-fold enhancement at 3.0 T), and approximately 5/6th of the 15N hyperpolarization is retained after ∼20 s long purification procedure. Taken together, these results help pave the way for future studies, involving in vivo molecular imaging using agents hyperpolarized via rapid and inexpensive parahydrogen-based methods.
Regulation of DNA replication and copy number are necessary to promote genome stability and maintain cell and tissue function. DNA replication is regulated temporally in a process known as replication timing (RT). Rif1 is key regulator of RT and has a critical function in copy number control in polyploid cells. In a previous study (Munden et al., 2018), we demonstrated that Rif1 functions with SUUR to inhibit replication fork progression and promote underreplication (UR) of specific genomic regions. How Rif1-dependent control of RT factors into its ability to promote UR is unknown. By applying a computational approach to measure RT in Drosophila polyploid cells, we show that SUUR and Rif1 have differential roles in controlling UR and RT. Our findings reveal that Rif1 functions both upstream and downstream of SUUR to promote UR. Our work provides new mechanistic insight into the process of UR and its links to RT.
To study the association of mononucleotide polymorphism rs6737848 SOCS5 gene with the risk of development of allergic bronchial asthma.

Totally 59 patients studied (19 males, 40 females) with allergic bronchial asthma and 50 healthy people (29 males, 21 females) of controls. All patients underwent clinical and instrumental and laboratory investigations in KICH №20 (Krasnoyarsk city) and molecular-genetic investigation of DNA in the Russia-Italian laboratory "MAGI" (Krasnoyarsk city) and Institution of Internal and Preventive Medicine (Novosibirsk city). Statistics included standard programs: Statistica for Windows 7.0.

The results of the study showed statistical predominance of prevalent genotype СС of SOCS5 gene in allergic bronchial asthma patients, comparing to control group. Homozygous genotype of СС gene of SOCS5 is a risk factor for allergic bronchial asthma.
The problem of the formation of the Russian model of management is interdisciplinary; it requires a whole range of approaches developed in various branches of knowledge. The philosophy of management is intended to serve as a common conceptual and interdisciplinary foundation that provides a holistic perception and understanding of management. It allows to view this phenomenon as a unity of science, practice and art. Among the axiological problems of the philosophy of management, the problems of organizational culture take center stage. To understand this phenomenon, we need a set of basic ideas about human nature, the meaning and form of activity, social reality, relationship with the external environment, the nature of human relations, etc. This notion of organizational culture can only be formed with a philosohical approach that allows implementing the integrating function of philosophy. The paper shows that the values of paternalism and security will be the near future priorities defining the development of Russian organizational culture.