Hengzongshu/ArticleAgent huggingface dataset:
The object of the research was to study the influence of sowing dates on sugar accumulation in different varieties of soft winter wheat. Less winterhardy variety of soft winter wheat Novosibirskaya 2 was compared with more winter-hardy ones Novosibirskaya 3, Novosibirskaya 40 and Krasnoobskaya ozimaya. The research was carried out in 2016-2018 inthe established experimental plot in the foreststeppe of Priobye, theObregion. The predecessor was bare fallow. The planting dates were August 20, September 1, September 10. Weather conditions of the autumn growing season, during which the accumulation of sugars occurs, differed significantly depending on the year of study and the sowing dates. The warmest conditions were in 2018, whereas the coolest – in 2017. The amount of accumulated sugars varied depending on the growing conditions and genotypic characteristics of varieties. The highest amount of sugars was accumulated by all varieties during the third term of planting, the lowest amount – during the second term. Lower air temperatures contributed to the increase in the amount of sugars, even when the duration of their accumulation period was shortened, which can be explained by a change in carbohydrate balance in crops when the accumulation of sugars is greater than their consumption for crop respiration. The genotype plays an important role in the carbohydrate metabolism of plants. In more winter-hardy varieties (Novosibirskaya 40, Novosibirskaya 3), the change in the amount of accumulated sugars in contrasting conditions ranged insignificantly (the coefficient of variation was 9.1 and 8.7%, respectively). At the same time, plants of the less winter-hardy variety of Novosibirskaya 2 showed a significantly greater variation in the sugar content under similar conditions (the coefficient of variation 24.7%). Cooler conditions of a later term of sowing contributed to the greatest amount of accumulated sugars. Varietal differences also determined changes in carbohydrate balance.
The method of spontaneous and induced luminol -dependent chemiluminescence in homogenates of rat retinas OXYS registered increase in the generation of free radicals against decrease in total antioxidant activity. With the ultra-microscopic and quantitative analysis revealed degenerative retinal neurons rats OXYS: the percentage increase in neurosensory cells with pyknosis of nuclei, hyperchromatic piknomorfnyh associative neurons and ganglion n eurons that have been modified on a light and dark type. Thiophane, limiting free radical reactions in the retina and protects retinal neurons from damage.
Ссылка для цитирования: Прогноз литологического состава баженовской свиты на основе комплексной интерпретации геологических и геофизических материалов / М.А. Фомин, Е.А. Костырева, С.В. Рыжкова, Р.М. Саитов, И.С. Сотнич, В.Г. Эдер // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2022. – Т. 333. – № 1. – С.154-167. В связи с истощением запасов нефти в традиционных гранулярных коллекторах в Западно-Сибирской нефтегазоносной провинции все большую значимость приобретает разработка и совершенствование технологических приемов, увеличивающих объемы добычи нефти из низкопроницаемых пород баженовской свиты. Перспективы нефтеносности этих пород в значительной степени зависят от их литологии. В этой связи разработка методического подхода расчета минерально-компонентного состава баженовской свиты в скважинах, не охарактеризованных керновым материалом, представляется актуальным исследованием. Объектом исследования являются карбонатно-глинисто-кремнистые породы баженовской свиты, характеризующиеся большой неоднородностью минерально-компонентного состава по разрезу. Цель: выявление и изучение взаимосвязей между литологическим составом пород и электрическими и радиоактивными свойствами баженовской свиты в центральной части Западно-Сибирского осадочного бассейна для разработки методики расчета содержания основных породообразующих компонентов в разрезе этой свиты. Методы: выявление взаимосвязей между минерально-компонентным составом пород баженовской свиты и ее электрическими и радиоактивными свойствами; статистический анализ полученных связей; расчет на их основе литологического состава баженовских пород в базовой, а также в соседних скважинах. Результаты. В статье изложены результаты комплексной литолого-геофизической интерпретации данных широкого комплекса электрического и радиоактивного каротажа и результатов аналитических исследований керна, на основе которых разработан и апробирован методический подход к расчету концентраций основных породообразующих компонентов баженовской свиты. Он основывается на выявленных взаимосвязях между минерально-компонентным составом пород и их физическими свойствами. Показана удовлетворительная сходимость расчетных значений и данных по керну, построена объемная литологическая модель для одной из скважин Дружной площади. Обосновано использование полученных взаимосвязей для достоверного расчета литологического состава баженовской свиты в близко расположенных скважинах, не охарактеризованных керновым материалом. Показана невозможность использования предлагаемого методического подхода на расстояния в несколько десятков км, а также в тонкослоистых разрезах.
Induced pluripotent stem (iPS) cells have been produced just for a few species among order Carnivora: snow leopard, Bengal tiger, serval, jaguar, cat, dog, ferret, and American mink.

We applied the iPS cell derivation protocol to the ringed seal (Phoca hispida) fibroblasts. The resulting cell line had the expression of pluripotency marker gene Rex1. Differentiation in embryoid body-like structures allowed us to register expression of AFP, endoderm marker, and Cdx2, trophectoderm marker, but not neuronal (ectoderm) markers. The cells readily differentiated into adipocytes and osteocytes, mesoderm cell types of origin. Transcriptome analysis allowed us to conclude that the cell line does not resemble human pluripotent cells, and, therefore, most probably is not pluripotent.

Thus, we produced ringed seal multipotent stem cell line capable of differentiation into adipocytes and osteocytes.
New experimental results on magnetic compression and transport of low-temperature arc plasma at ∼3 m distance are presented. The magnetic compression ratio of the plasma stream varied from 5 to 60 at the initial plasma diameter about 5 cm. Theory predicts that the multiple-mirror magnetic field should not significantly decelerate and weaken the collisional low-temperature arc plasma. In the experiments, the transport efficiency of the plasma stream in the multiple-mirror configuration of the solenoid was compared with the same in a uniform solenoidal field. As the result, the plasma with (1–4)×1020 m−3 density at the axis was obtained at ∼3 m distance from the arc plasma source. The experiments simulated the baseline scenario of GOL-NB filling by the start plasma. Finally, the experiments described in the paper validated the decisions made for the GOL-NB start plasma source.
A study, involving kinetic measurements on the stopped‐flow and conventional UV/Vis timescales, ESI‐MS, NMR spectroscopy and DFT calculations, has been carried out to understand the mechanism of the reaction of [Mo 3 S 4 (acac) 3 (py) 3 ][PF 6 ] ([ 1 ]PF 6 ; acac=acetylacetonate, py=pyridine) with two RCCR alkynes (R=CH 2 OH (btd), COOH (adc)) in CH 3 CN. Both reactions show polyphasic kinetics, but experimental and computational data indicate that alkyne activation occurs in a single kinetic step through a concerted mechanism similar to that of organic [3+2] cycloaddition reactions, in this case through the interaction with one Mo(μ‐S) 2 moiety of [ 1 ] + .

Activation strain analysis of the [3+2] cycloaddition step reveals that the deformation of the two reactants has a small contribution to the difference in the computed activation barriers, which is mainly associated with the change in the extent of their interaction at the transition‐state structures. Subsequent frontier molecular orbital analysis shows that the carboxylic acid substituents on adc stabilize its HOMO and LUMO orbitals with respect to those on btd due to better electron‐withdrawing properties.

The rate of this step is three orders of magnitude faster for adc than that for btd, and the products initially formed evolve in subsequent steps into compounds that result from substitution of py ligands or from reorganization to give species with different structures. As a result, the frontier molecular orbitals of the cluster and alkyne become closer in energy; this allows a stronger interaction.
The relationship between compartmentalisation of the genome and epigenetics is long and hoary. In 1928 Heitz defined heterochromatin as the largest differentiated chromatin compartment in eukaryotic nuclei. Müller’s (1930) discovery of position-effect variegation (PEV) went on to show that heterochromatin is a cytologically-visible state of heritable (epigenetic) gene repression. Current insights into compartmentalisation have come from a high-throughput top-down approach where contact frequency (Hi-C) maps revealed the presence of compartmental domains that segregate the genome into heterochromatin and euchromatin. It has been argued that the compartmentalisation seen in Hi-C maps is due to the physiochemical process of phase separation. Oddly, the insights provided by these experimental and conceptual advances have remained largely silent on how Hi-C maps and phase separation relate to epigenetics.

Addressing this issue directly in mammals, we have made use of a bottom-up approach starting with the hallmarks of constitutive heterochromatin, heterochromatin protein 1 (HP1) and its binding partner the H3K9me2/3 determinant of the histone code. They are key epigenetic regulators in eukaryotes. Both hallmarks are also found outside mammalian constitutive heterochromatin as constituents of larger (0.1-5Mb) heterochromatin -like domains and smaller (less than 100Kb) complexes. The well-documented ability of HP1 proteins to function as bridges between H3K9me2/3-marked nucleosomes enables cross-linking within and between chromatin fibres that contributes to polymer-polymer phase separation (PPPS) that packages epigenetically-heritable chromatin states during interphase. Contacts mediated by HP1 “bridging” are likely to have been detected in Hi-C maps, as evidenced by the B4 heterochromatic sub-compartment that emerges from contacts between large KRAB-ZNF heterochromatin -like domains. Further, mutational analyses have revealed a finer, innate, compartmentalisation in Hi-C experiments that likely reflect contacts involving smaller domains/complexes.

Proteins that bridge (modified) DNA and histones in nucleosomal fibres – where the HP1-H3K9me2/3 interaction represents the most evolutionarily-conserved paradigm – could drive and generate the fundamental compartmentalisation of the interphase nucleus. This has implications for the mechanism(s) that maintains cellular identity, be it a terminally-differentiated fibroblast or a pluripotent embryonic stem cell.
In this work we consider Malcev bialgebras.

We describe all structures of a Malcev bialgebra

on a simple non-Lie Malcev algebra.
The technology of solid-state light source is associated with the future of a number of sectors of economy. Duration of failure-free operation, optical radiation power and other output characteristics of the LEDs are closely linked with p-n junction temperature, which makes the development of the cooling systems an important step in creating LED systems.

In this work, we have created a new type of thermosiphon for studying heat transfer from a local heat source. Boiling heat transfer on the local heaters with the diameter of 1 and 5 mm has been investigated.

It is shown that on the finned surfaces overheating relative to the saturation temperature in comparison with a smooth surface decreases up to three times for the heater with the diameter of 5 mm. For finned surfaces on the heater with a diameter of 1 mm, surface overheating relative to the saturation temperature decreases four times. More than three times increase is observed for the heat transfer coefficient on finned surfaces as compared to the smooth ones. It is shown that the value of the critical heat flux (CHF) under the conditions of a large volume of liquid for the heaters with D = 1.6 and 5 mm is in good agreement with the known dependences. Radial finning of the heater has no effect on CHF. The value of CHF for D = 1 mm turns out to be higher than the calculated one. The greatest increase is achieved by using a head with finning.
Seismic tomography provides a window into magmatic plumbing systems; however, obtaining sufficient data for 'real-time' imaging is challenging. Until now, syn-eruptive tomography has not been successfully demonstrated.

For the first time, we obtained high-resolution images of Earth's interior during an ongoing volcanic eruption. We used data from 11,349 earthquakes, most of which during La Palma eruption (19 September-13 December, 2021), to perform travel-time seismic tomography. We present high-precision earthquake relocations and 3D distributions of P and S-wave velocities highlighting the geometry of magma sources.

We identified three distinct structures: (1) a shallow localised region (< 3 km) of hydrothermal alteration; (2) spatially extensive, consolidated, oceanic crust extending to ~10 km depth and; (3) a large (> 400 km 3 ) sub-crustal magma-filled rock volume intrusion extending from ~7 to 25 km depth. Our results suggest that this large magma reservoir feeds the La Palma eruption continuously for almost three months. Prior to eruption onset, magma ascended from ~10 km depth to the surface in < 7 days. In the upper 3 km, melt migration is along the western contact between consolidated oceanic crust and altered hydrothermal material. Similar structural weaknesses along the eastern contact could potentially cause new eruptive centres in the future.
Background Merlin, the product of the Neurofibromatosis type 2 ( NF2 ) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell surface glycoproteins to the actin cytoskeleton. While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa.

Results By combining bioinformatic and phylogenetic approaches, we demonstrate that merlin homologs are present across a wide range of metazoan lineages. While the phylogenetic tree shows a monophyletic origin of the ERM family, the origin of the merlin proteins is robustly separated from that of the ERM proteins. The derivation of merlin is thought to be in early metazoa. We have also observed the expansion of the ERM-like proteins within the vertebrate clade, which occurred after its separation from Urochordata ( Ciona intestinalis ). Amino acid sequence alignment reveals the absence of an actin-binding site in the C-terminal region of all merlin proteins from various species but the presence of a conserved internal binding site in the N-terminal domain of the merlin and ERM proteins. In addition, a more conserved pattern of amino acid residues is found in the region containing the so-called "Blue Box," although some amino acid substitutions in this region exist in the merlin sequences of worms, fish, and Ciona . Examination of sequence variability at functionally significant sites, including the serine-518 residue, the phosphorylation of which modulates merlin's intra-molecular association and function as a tumor suppressor, identifies several potentially important sites that are conserved among all merlin proteins but divergent in the ERM proteins. Secondary structure prediction reveals the presence of a conserved α-helical domain in the central to C-terminal region of the merlin proteins of various species. The conserved residues and structures identified correspond to the important sites highlighted by the available crystal structures of the merlin and ERM proteins. Furthermore, analysis of the merlin gene structures from various organisms reveals the increase of gene length during evolution due to the expansion of introns; however, a reduction of intron number and length appears to occur in the merlin gene of the insect group.

Conclusion Our results demonstrate a monophyletic origin of the merlin proteins with their root in the early metazoa. The overall similarity among the primary and secondary structures of all merlin proteins and the conservation of several functionally important residues suggest a universal role for merlin in a wide range of metazoa.
Background Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at post-transcriptional level and are implicated in the regulation of various cellular processes during the parasite- host interplay. However, to date, the miRNAs of opisthorchiid flukes, in particular those essential for maintaining their complex biology and parasitic mode of existence, have not been satisfactorily described.

Methodology/Principal Findings Using a SOLiD deep sequencing-bioinformatic approach, we identified 43 novel and 18 conserved miRNAs for O. felineus (miracidia, metacercariae and adult worms), 20 novel and 16 conserved miRNAs for O. viverrini (adult worms), and 33 novel and 18 conserved miRNAs for C. sinensis (adult worms). The analysis of the data revealed differences in the expression level of conserved miRNAs among the three species and among three the developmental stages of O. felineus. Analysis of miRNA genes revealed two gene clusters, one cluster-like region and one intronic miRNA in the genome. The presence and structure of the two gene clusters were validated using a PCR-based approach in the three flukes.

Conclusions This study represents a comprehensive description of miRNAs in three members of the family Opistorchiidae, significantly expands our knowledge of miRNAs in multicellular parasites and provides a basis for understanding the structural and functional evolution of miRNAs in these metazoan parasites. Results of this study also provides novel resources for deeper understanding the complex parasite biology, for further research on the pathogenesis and molecular events of disease induced by the liver flukes. The present data may also facilitate the development of novel approaches for the prevention and treatment of opisthorchiasis/clonorchiasis.
In our paper we present the results of seismotomographic inversion for the local seismological monitoring data obtained in the area of the Samoylov Island (Lena River delta) in 2019–2021.

Tomographic velocity model was used for refining hypocenter locations of local earthquakes and for geological interpretation. The results are shown as maps of anomalies of seismic waves and Vp/Vs ratios for the 5 and 10 km depths.

The velocity anomalies structure made it possible to interpret low Vp/Vs ratio as rocks related to the Siberian platform, and to compare between the boundary of the low Vp/Vs area and the trace of the known geological fault running along the Olenekskaya Channel.
We study B- meson decays to pbar Lambda D(*)0 final states using a sample of 657 * 10^6 B Bbar events collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider.

The observed branching fraction for B- to pbar Lambda D0 is (1.43^ +0.28_-0.25 +- 0.18)*10^-5. with a significance of 8.1 standard deviations, where the uncertainties are statistical and systematic, respectively. Most of the signal events have the pbarLambda mass peaking near threshold.

No significant signal is observed for B- to pbar Lambda D*0 and the corresponding upper limit on the branching fraction is 4.8 * 10^-5 at the 90% confidence level.
The early development of behavioral types and the influence of environmental, mostly social, factors have almost not been studied for natural animal populations.

We investigated the effect of the density of non‐relative social environment on the development of the behavior of free‐living chicks of the Black‐headed Gull ( Chroicocephalus ridibundus ). In order to exclude the influence of relationships with native parents on the development of chicks' behavior, 21 clutches were cross‐fostered so as to destroy any negative relationship between the aggressiveness of their parents and the density of their neighbors. The behavioral types of chicks were determined by a 3‐time testing in an “open field” arena at the ages of 2‐3, 8‐9 and 14‐15 days.

Those parents, which effectively coped with close neighboring at the nest settling period, raised more active offspring. The behavior of chicks raised by foster parents, on the contrary, was more passive the fewer unrelated chicks there were nearby and was not associated with the aggressiveness of their parents. Our work demonstrates the role of an unrelated social environment in the ontogeny of behavioral types in colonial birds. We suppose that the different ways in which influences of parents and neighbors optimize the trajectories of development of behavioral types at an individual level, increase the chances of chicks surviving in the diverse and variable environment of a breeding colony.
The development of active and stable photocatalysts for the degradation of volatile organic compounds under visible light is important for efficient light utilization and environmental protection. Titanium dioxide doped with nitrogen is known to have a high activity but it exhibits a relatively low stability due to a gradual degradation of nitrogen species under highly powerful radiation. In this paper, we show that the combination of N-doped TiO
Minerals, metals, inorganic materials, ices, gas hydrates and clathrates are ''traditional'' systems for high-pressure studies.On the other hand, high-pressure studies of complex biological systems, in particular, of proteins, are becoming more and more common.The effects of high pressure on organic molecular crystals were described in the early classical works by P. Bridgman and L. Vereshchagin, but these systems remained very little studied until the systematic work initiated by A. Katrusiak in the late 1970s, who has combined precise X-ray single-crystal diffraction studies, spectroscopy and calorimetry.

In the last years, however, more and more research groups join the highpressure studies of organic molecular crystals, and in this presentation I shall try to illustrate on several examples, mainly from my own experience, why these studies are so challenging and promising.

In particular, I shall consider: the studies of the anisotropy of structural strain within the range of stability of the same polymorph as a tool to study intermolecular interactions, thermodynamic and kinetic aspects of pressure-induced phase transitions, comparison of the low-temperature and highpressure behaviour, high-pressure studies of the polymorphism of drugs in relation to tabletting procedure in industry, organic molecular crystals as biomimetics -high-pressure behaviour in relation to folding.