Hengzongshu/ArticleAgent huggingface dataset:
T and NK cells armed with chimeric antigen receptors (CAR) are promising tools for the specific elimination of cancer cells. In most CAR designs implemented to date, the recognition of target cells is mediated by single-chain variable fragments (scFvs) derived from murine monoclonal antibodies. This format, however, has a number of limitations, including its relatively large size and potential immunogenicity in humans. In this study, we explored the feasibility of using human fibronectin type III domains (Fn3) as the antigen recognition domain in CARs. Human Fn3 domains have lower predicted immunogenicity compared to mouse-derived sequences, and a reduced molecular weight compared to scFvs. We created a functional CAR using a VEGFR2-specific Fn3 module replacing the conventional scFv. The resulting FnCAR specifically potentiates the cytotoxic activity of human T cells and YT NK cells in the presence of VEGFR2-positive targets. These findings demonstrate that Fn3 domains can be used in CARs for antigen recognition.
The CMD-3 detector has been successfully collecting data at the electron-positron collider VEPP-2000 since December 2010.

The first scan below 1 GeV for a π + π − measurement was performed in 2013. The collected data sample corresponds to about 18 pb −1 of integrated luminosity in this energy range.

Analysis of the e + e − → π + π − cross section is in progress. Status of this measurement are presented.
Arabinogalactan, a water-soluble natural polysaccharide, has potent innate immuno-modulatory and anti-cancer activity and can serve as a carrier material in targeted drug delivery. The molecular weight and supramolecular structure of the polymer are very important for its pharmacological and technological applications.

In this work, we used synchrotron small-angle X-ray scattering as an instrument to study the supramolecular structure of arabinogalactan in aqueous solutions. The formation of polymer associates was confirmed also by means of the terahertz laser ablation and atomic force microscopy studies. SAXS experiments were made at accelerators complex VEPP-3/VEPP-4.

The formation of polymer associates was confirmed.
Generalized Hidden Local Symmetry (GHLS) model is the chiral model of pseudoscalar, vector, and axial vector mesons and their interactions. It contains also the couplings of strongly interacting particles with electroweak gauge bosons.

Here, GHLS model is confronted with the ALEPH data on the decay $\tau^-\to\pi^-\pi^-\pi^+\nu_\tau$. It is shown that the invariant mass spectrum of final pions in this decay calculated in GHLS framework with the single $a_1(1260)$ resonance disagrees with the experimental data at any reasonable number of free GHLS parameters. Two modifications of GHLS model based on inclusion of two additional heavier axial vector mesons are studied.

One of them giving a good description of the ALEPH data, with all the parameters kept free is shown to result in very large $\Gamma_{a_1^\pm\to\pi^\pm\gamma}$ partial width. The other scheme with the GHLS parameters fixed in a way that the universality is preserved and the observed central value of $\Gamma_{a_1^\pm\to\pi^\pm\gamma}$ is reached, results in a good description of the three pion spectrum in $\tau^-\to\pi^+\pi^-\pi^-\nu_\tau$ decay.
The search of scientific information was carried out in order to expand opportunities for rehabilitation of people having low limbs (legs and feet) diseases.The techniques were developed for customizing of the orthopedic footwear intended for different abnormalities of low limbs.Having studied the abnormalities in movements and having carried out the anthropometric examinations of feet, the classifications of corrective elements of an orthopedic insole, hard details and typical constructions of orthopedic boots were developed, as well as the classification of boots was created taking into account the rehabilitation effect.
It has been discussed the notion of an organized molecular assemblies as the key problem of the low-dimension systems physics and the supramolecular chemistry. An organized molecular assembly is a group of atoms or molecules built in a solid matrix due to chemical or intermolecular interactions and possessing, in total, the ability to produce a definite response to the given perturbation. The effectiveness of this approach has been shown on examples the search for systems that evolve to the formation of two dimensional organized molecular assemblies at the boundary between a semiconductor crystal and a dielectric and also creating quantum dots and chemical sensors.
This special issue is intended to serve as a multidisciplinary forum covering broad aspects of the science, technology, and application of synthetic and natural diamonds. This special issue contains 12 papers, which highlight recent investigations and developments in diamond research related to the diverse problems of natural diamond genesis, diamond synthesis and growth using CVD and HPHT techniques, and the use of diamond in both traditional applications, such as mechanical machining of materials, and the new recently emerged areas, such as quantum technologies.

The results presented in the contributions collected in this special issue clearly demonstrate that diamond occupies a very special place in modern science and technology. After decades of research, this structurally very simple material still poses many intriguing scientific questions and technological challenges. It seems undoubted that diamond will remain the center of attraction for many researchers for many years to come.
The metal–organic framework (MOF) complex (H 3 O) 2 [Zn 4 (ur)(Hfdc) 2 (fdc) 4 ] ( 1 , ur=urotropine, H 2 fdc=furan‐2,5‐dicarboxylic acid) incorporates cryptand‐like cavities, which can be used to separate and detect Rb + and Cs + optically. This is the first example of the effective employment of a MOF material for optical detection of these cations.
The colored grain of wheat (Triticum aestivum L.) contains a large number of polyphenolic compounds that are biologically active ingredients.

The purpose of this work was a comparative metabolomic study of extracts from anthocyaninless (control), blue, and deep purple (referred to here as black) grains of seven genetically related wheat lines developed for the grain anthocyanin pigmentation trait. To identify target analytes in ethanol extracts, high-performance liquid chromatography was used in combination with Bruker Daltonics ion trap mass spectrometry.

The results showed the presence of 125 biologically active compounds of a phenolic (85) and nonphenolic (40) nature in the grains of T. aestivum (seven lines). Among them, a number of phenolic compounds affiliated with anthocyanins, coumarins, dihydrochalcones, flavan-3-ols, flavanone, flavones, flavonols, hydroxybenzoic acids, hydroxycinnamic acids, isoflavone, lignans, other phenolic acids, stilbenes, and nonphenolic compounds affiliated with alkaloids, carboxylic acids, carotenoids, diterpenoids, essential amino acids, triterpenoids, sterols, nonessential amino acids, phytohormones, purines, and thromboxane receptor antagonists were found in T. aestivum grains for the first time. A comparative analysis of the diversity of the compounds revealed that the lines do not differ from each other in the proportion of phenolic (53.3% to 70.3% of the total number of identified compounds) and nonphenolic compounds (46.7% to 29.7%), but diversity of the compounds was significantly lower in grains of the control line. Even though the lines are genetically closely related and possess similar chemical profiles, some line-specific individual compounds were identified that constitute unique chemical fingerprints and allow to distinguish each line from the six others. Finally, the influence of the genotype on the chemical profiles of the wheat grains is discussed.
Mathematical problems and their solutions from the fourth International Students’ Olympiad in cryptography (NSUCRYPTO-2017) are presented. We consider problems related to attacks on ciphers and hash functions, cryptographic Boolean functions, linear branch numbers, addition chains, and error correction codes, among others. We discuss several open problems involving the algebraic structures of cryptographic functions, useful proof-of-work algorithms, the Boolean hidden shift problem, and quantum computing.
Viroids belong to a very interesting class of molecules attracting researchers in phytopathology and molecular evolution.

Here we review recent literature data concerning the genetics of Potato spindle tuber viroid (PSTVd) and the mechanisms related to its pathological effect on the host plants. PSTVd can be transmitted vertically through microspores and macrospores, but not with pollen from another infected plant. The 359 nucleotidelong genomic RNA of PSTVd is highly structured and its 3D-conformation is responsible for interaction with host cellular factors to mediate replication, transport between tissues during systemic infection and the severity of pathological symptoms. RNA replication is prone to errors and infected plants contain a population of mutated forms of the PSTVd genome. Interestingly, at 7 DAI, only 25 % of the newly synthesized RNAs were identical to the master copy, but this proportion increased to up to 70 % at 14 DAI and remained the same afterwards. PSTVd infection induces the immune response in host plants. There are PSTVd strains with a severe, a moderate or a mild pathological effect. Interestingly, viroid replication itself does not necessarily induce strong morphological or physiological symptoms. In the case of PSTVd, disease symptoms may occur due to RNA-interference, which decreases the expression levels of some important cellular regulatory factors, such as, for example, potato StTCP23 from the gibberellic acid pathway with a role in tuber morphogenesis or tomato FRIGIDA-like protein 3 with an early flowering phenotype.

This association between the small segments of viroid genomic RNAs complementary to the untranslated regions of cellular mRNAs and disease symptoms provides a way for new resistant cultivars to be developed by genetic editing. To conclude, viroids provide a unique model to reveal the fundamental features of living systems, which appeared early in evolution and still remain undiscovered.
The purpose of the study is to analyze two Russian titles of J. Austen's novel Sense and Sensibility translated by Irina G. Gurova (1988) and Alla Yu. Frolova (2013). The meanings of the lexemes sense and sensibility in English (in the 18-19th centuries and nowadays) are compared with the meanings of their corresponding translations in the modern Russian language.

The most important meanings of the Russian lexemes are identified by using associative databases: Russian regional associative dictionary-thesaurus EVRAS (Institute of Linguistics, RAS) and Russian regional associative database SIBAS (Institute of Linguistics, RAS; Institute of Philology, SB RAS; Novosibirsk State University).

In the conclusion «Разум и чувство» [razum i chuvstvo] (i.e. Reason and Feeling) by Alla Yu. Frolova is argued to be the best relevant translation of the novel title. The author of the article also suggests her own possible Russian versions of the novel title, not only taking into account the opposition of the rational and irrational components, but also reflecting the alliteration that takes place in the English original. The analysis is a part of a larger research based on studying the full-text versions of J. Austen's novel Sense and Sensibility done by Russian and French translators.
Ultramafic lamprophyres (UMLs) are mantle rocks that provide important information about the composition of specific carbonate–silicate alkaline melts in the mantle as well as the processes contributing to their origin. Minerals of the spinel group typically occur in UMLs and have a unique 'genetic memory.'

Investigations of the spinel minerals from the UMLs of the Chadobets complex show the physicochemical and thermodynamic features of the alkaline rocks' crystallization. The spinels of these UMLs have four stages of crystallization. Melt inclusion analyses showed the predominance of aluminosilicate (phlogopite, clinopyroxene, and/or albite) and carbonate (calcite and dolomite) daughter phases in the inclusions that are consistent with the chemical evolution of the Cr-spinel trend.

The first spinel xenocrysts were found only in damtjernite pipes, formed from mantle peridotite, and were captured during the rising of the primary melt to the surface. The next stages of the spinel composition evolution are related to the high-chromium spinel crystallization, which changed to a high-alumina composition. The composition then changed to magnesian ulvöspinel–magnetites with strong decreases in the Al and Cr amounts caused by the release of carbon dioxide, rapid temperature changes, and crystallization of the main primary groundmass minerals such as phlogopite and carbonates. The further evolution of the spinels from magnesian ulvöspinel–magnetite to Ti-magnetite is accompanied by the formation of atoll structures caused by resorption of the spinel minerals.
Superionic solid electrolyte Ag 16 I 12 P 2 O 7 was prepared using solid state synthesis. The ionic conductivity of this compound was studied by the complex impedance spectroscopy method in a wide temperature range. It is shown that Ag 16 I 12 P 2 O 7 is characterized by a high ionic conductivity at room temperature, comparable to the conductivity of liquid electrolytes.
Microbial ecosystems of the built environments have become key mediators of health as people worldwide tend to spend large amount of time indoors. Underexposure to microbes at an early age is linked to increased risks of allergic and autoimmune diseases. Transportation systems are of particular interest, as they are globally the largest space for interactions between city-dwellers.

Here we performed the first pilot study of the Moscow subway microbiome by analyzing swabs collected from 5 types of surfaces at 4 stations using high-throughput 16S rRNA gene sequencing. The study was conducted as a part of The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) project.

The most abundant microbial taxa comprising the subway microbiome originated from soil and human skin. Microbiome diversity was positively correlated with passenger traffic. No substantial evidence of major human pathogens presence was found. Co-occurrence analysis revealed clusters of microbial genera including combinations of microbes likely originating from different niches. The clusters as well as the most abundant microbes were similar to ones obtained for the published data on New-York City subway microbiome. Our results suggest that people are the main source and driving force of diversity in subway-associated microbiome. The data form a basis for a wider survey of Moscow subway microbiome to explore its longitudinal dynamics by analyzing an extended set of sample types and stations. Complementation of methods with viability testing, "shotgun" metagenomics, sequencing of bacterial isolates and culturomics will provide insights for public health, biosafety, microbial ecology and urban design.
Quantum computing and quantum information processing (QC/QIP) crucially depend on the availability of suitable quantum bits (qubits) and methods of their manipulation. Most qubit candidates known to date are not applicable at ambient conditions. Herein, we propose radical‐grafted mesoporous silica as a versatile and prospective nanoplatform for spin‐based QC/QIP. Extremely stable Blatter‐type organic radicals are used, whose electron spin decoherence time is profoundly long even at room temperature (up to T m ≈2.3 μs), thus allowing efficient spin manipulation by microwave pulses. The mesoporous structure of such composites is nuclear‐spin free and provides additional opportunities of embedding guest molecules into the channels. Robustness and tunability of these materials promotes them as highly promising nanoplatforms for future QC/QIP developments.
In this communication, we report on a noteworthy hybrid supramolecular assembly built from three functional components hierarchically organized through noncovalent interactions. The one-pot synthesis procedure leads to the formation of large Mo-blue ring-shaped anion {Mo154}, which contains the supramolecular adduct based on the symmetric encapsulation of the Dawson-type [P2W18O62]6– anion by two γ-cyclodextrin units. Such a nanoscopic onion-like structure, noted [P2W18O62]@2γ-CD@{Mo154} has been characterized by single-crystal X-ray diffraction, thus demonstrating the capability of the giant inorganic torus to develop relevant supramolecular chemistry, probing the strong affinity of the inner and outer faces of the γ-CD for the polyoxometalate surfaces. Furthermore, interactions and behavior in solution have been studied by multinuclear NMR spectroscopy, which supports specific interactions between γ-CD and POM units. Finally, the formation of this three-component hybrid assembly from one-pot procedure, in water and using nearly stoichiometric conditions, is discussed in terms of the driving forces orchestrating this highly efficient multilevel recognition process.
We study ballistic electron transport in suspended semiconductor nanostructures containing high mobility two dimensional electron gas structured with periodical square lattice of artificial scatters — antidots. Thermopower demonstrates magnetic field commensurability oscillations resulting from geometrical resonances similar to those earlier observed in magnetoresistance, thus indicating the retaining of the ballistic regime in thermopower measurement on suspended structures and the validity of the Mott rule in this case. In spite of peculiarities of the heat transport in suspended structures leading to the observed anomalies in non-linear effects, the amplitude of thermopower oscillations remains unchanged after the suspension. This can be explained by short Thouless time compared to the time of electron- phonon interaction.
Hypertrophic cardiomyopathy (HCM) is a common cardiovascular disease. However, effective methods of its therapy have not been developed so far. To date patient-specific induced pluripotent stem cell-derived cardiomyocytes are supposed to be a useful tool for studying HCM molecular mechanisms and to help find new approaches to HCM therapy. Using non-integrating episomal vectors, we generated an iPSC line from peripheral blood mononuclear cells of an HCM patient carrying a heterozygous p.N515del mutation in MYBPC3. The iPSC line expressed pluripotency markers, gave rise to derivatives of three germ layers during spontaneous differentiation, had normal karyotype, and retained the patient-specific mutation.
. Production of hyperpolarized catalyst-free gases and liquids by heterogeneous hydrogenation with parahydrogen (HET-PHIP) can be useful for various technical as well as biomedical applications, including in vivo studies, investigations of mechanisms of industrially important catalytic processes, enrichment of nuclear spin isomers of polyatomic gases, and more. In this regard, the wide systematic search for heterogeneous catalysts effective in pairwise H2 addition required for the observation of PHIP effects is crucial. Here in this work we demonstrate the competitive advantage of Pd-based bimetallic catalysts for HET-PHIP. The dilution of catalytically active Pd with less active Ag or In atoms provides the formation of atomically dispersed Pd1 sites on the surface of Pd-based bimetallic catalysts, which are significantly more selective toward pairwise H2 addition compared to the monometallic Pd. Furthermore, the choice of the dilution metal (Ag or In) has a pronounced effect on the efficiency of bimetallic catalysts in HET-PHIP, as revealed by comparing Pd-Ag and Pd-In bimetallic catalysts.
The complex spin order of hyperpolarized multispin systems giving rise to anomalous NMR spectral patterns that vary with the RF excitation angle is analyzed by decomposing its nutation behavior in a superposition of Fourier harmonics.

The product operator formalism is applied to calculating the spectral contributions of the various mutual alignments of scalar coupled spins. Two cases are treated, namely systems exhibiting only differences in population of their spin states and systems showing in addition zero-quantum coherences between states, a situation often seen at hyperpolarization. After deriving the general solution a number of representative examples are discussed in detail.

The theoretical treatment is applied to analyzing the spin order observed in a hyperpolarized two-spin system that is prepared in the singlet state by para-hydrogen induced polarization.
Vaccination is the most simple and reliable approach of protection to virus infections. The most effective agents are live vaccines, usually low-virulence organisms for humans and closely related to pathogenic viruses or attenuated as a result of mutations/deletions in the genome of pathogenic virus. Smallpox vaccination with live vaccinia virus (VACV) closely related to smallpox virus played a key role in the success of the global smallpox eradication program carried out under the World Health Organization auspices. As a result of the WHO decision as of 1980 to stop smallpox vaccination, humankind has lost immunity not only to smallpox, but also to other zoonotic, orthopoxviruscaused human infections.

VACV attenuation by modern approaches carried out by targeted inactivation of certain virus genes and usually leads to a decrease in the effectiveness of VACV in vivo propagation. The gene for thymidine kinase is frequently used for insertion/inactivation of foreign genes and it causes virus attenuation. In this research, the effect of the introduction of two point mutations into the A34R gene of attenuated strain LIVP-GFP (ТК-), which increase the yield of extracellular enveloped virions (EEV), on the pathogenicity and immunogenicity of VACV LIVP-GFP-A34R administered intranasally to laboratory mice were studied.

It was shown that increase in EEV production by recombinant strain VACV LIVP-GFP-A34R does not change the attenuated phenotype characteristic of the parental strain LIVP-GFP, but causes a significantly larger production of VACV-specific antibodies.
In this work, we suggest and discuss several new algorithms for iterative image reconstruction in emission tomography. The new iterative formulas allow varying the rate of convergence and image corruption by adjusting the parameters of the algorithms.
The Production and Distributed Analysis system (PanDA), used for workload management in the ATLAS Experiment at the LHC for over a decade, has in recent years expanded its reach to diverse new resource types such as HPCs, and innovative new workflows such as the Event Service. PanDA meets the heterogeneous resources it harvests in the PanDA Pilot, which has embarked on a next-generation reengineering to efficiently integrate and exploit the new platforms and workflows. The new modular architecture is the product of a year of design and prototyping in conjunction with the design of a completely new component, Harvester, that will mediate a richer flow of control and information between Pilot and PanDA. Harvester will enable more intelligent and dynamic matching between processing tasks and resources, with an initial focus on HPCs, simplifying the operator and user view of a PanDA site but internally leveraging deep information gathering on the resource to accrue detailed knowledge of a site's capabilities and dynamic state to inform the matchmaking. This paper will give an overview of the new Pilot architecture, how it will be used in and beyond ATLAS, its relation to Harvester, and the work ahead.
This paper presents an overview of the studies on the interaction of a high-power relativistic electron beam (REB) with dense plasma confined in a long open magnetic trap. The main goal of this research is to achieve plasma parameters close to those required for thermonuclear fusion burning. The experimental studies were carried over the course of four decades on various devices: INAR, GOL, INAR-2, GOL-M, and GOL-3 (Budker Institute of Nuclear Physics) for a wide range of beam and plasma parameters.