Hengzongshu/ArticleAgent huggingface dataset:
We compare two recently developed sets of source terms, based on different assumptions of wave energy input and dissipation, for Hasselmann equation. The numerical simulation, performed for limited fetch conditions with the constant wind speed shows the difference in total energy and mean frequency distributions along the fetch as well as in wave energy spectra. Possible reasons of such deviations are offered.
The aim of this study was to compare and analyze the effectiveness of protein markers of myocardial necrosis - heart-type fatty acid-binding protein (H-FABP) and the MB fraction of creatine phosphokinase (CPK-MB) in the dynamics of acute coronary syndrome. Material and methods. A total of 49 patients (57.1 ± 11,0 years) were examined, including 36 male patients (73.5 %) who were admitted to the City Clinical Hospital No. 34 of Novosibirsk with suspected acute coronary syndrome. The content of H-FABP in whole venous blood was evaluated for all patients upon admission to the hospital with the means of the immunochromatographic rapid test «CardioPBFA» (NPO «Biotest», Novosibirsk) with a sensitivity of 15 ng/ml. Determination of CPK-MB was carried out repeatedly in the first 48 hours from the beginning of the clinical manifestations of the disease, using immunochemiluminometric assay. Results and discussion. It was revealed that in patients with myocardial infarction (MI), CPK-MB content after 6-24 hours and also after 24-48 hours from the onset of pain was significantly higher than in patients without MI. H-FABP content 15 ng/ml and more, determined in the majority of patients in the first 6 hours from the onset of pain, was recorded much more often in MI presence than in MI absence. Using partial correlation analysis, it was determined that age influenced the association of MI with CPK-MB 6-24 hours after the onset of pain (which is probably due to the increase in the influence of a number of factors modulating the level of protein cardiac markers with age), and the correlation of MI with CPK-MB in 24-48 hours from the onset of pain did not depend on this factor ( r = 0.322; p = 0.46). In the regression model (χ² = 13.6; p = 0.001) it was revealed that H-FABP content 15 ng/ml and more regardless of age ( p = 0.006) is associated with the presence of MI in the patients, which confirms information about the high significance of identifying this H-FABP level in early diagnosis of myocardial infarction.
The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar-phosphate backbone 5′ to an AP-site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate and 3′-hydroxyl end groups. APE1 can also recognise and incise some damaged or modified nucleotides as well as possesses some minor activities: 3′-5′ exonuclease, 3′-phosphodiesterase, 3′-phosphatase and RNase H. A molecular explanation for the discrimination of structurally different substrates by the single active site of the enzyme remains elusive. Here we report a mechanism of target nucleotide recognition by APE1 as revealed by the results of an analysis of the APE1 process involving damaged DNA and native RNA substrates with non-canonical structures. The mechanism responsible for substrate specificity proved to be directly related to the ability of a target nucleotide to get into the active site of APE1 in response to an enzyme-induced DNA distortion. It was found for the first time that APE1 can cleave even undamaged DNA within non-B-form structures thereby strongly supporting the identified mechanism of target nucleotide recognition.
This paper deals with a mathematical model of the phase transition of the first kind at the initial stage of forming drops in a liquid or in melted state in a volume of steam with a fixed charge on drops.

The model of the process is represented by superposition of random diffusion and jump stochastic processes. The algorithms for solving stochastic differential equations (SDEs) of the model of processes, which form the cluster size, allow one to calculate a distribution function of drops according to their size.

The kinetic approach makes possible evaluate the role of the Rayleigh capillary instability at the initial condensation stage and to employ the analysis of electrodispersion mechanisms in the production of metal and semiconductor powders.
The multitude of existing methods for assessing the phenotypic stability of plants makes breeders be faced with the problem of choosing an appropriate variant. The purpose of this study was to compare different methods of analyzing the genotype x environment interaction and, on their basis, assess the stability of the yield of 7 varieties of winter wheat. The article compares 17 stability statistics by applying them to data obtained from agrotechnical experiments carried in 2009-2011 for evaluating the grain yield of 7 varieties of winter common wheat of Siberian selection (Novosibirskaya 32, Novosibirskaya 40, Novosibirskaya 51, Novosibirskaya 3, Novosibirskaya 2, Obskaya winter, Omskaya 6). Analysis of variance revealed a significant (p < 0.001) genotype x environment interaction in the experiments, which indicates a different reaction of genotypes to changes in environmental conditions. Genotypes were ranked according to the level of stability. Based on the analysis of the rank correlation matrix, the stability statistics were categorized in five groups. Recommendations were made on which group of methods to use depending on the objectives of the study. In the case when the goal of breeding research is the selection of the most biologically stable varieties with the minimum variance across a range of environments, one should use the methods of the static concept. If it is necessary to choose a genotype with a predictable reaction to changes of environmental conditions, corresponding to the calculated level or forecast, the regression approach is the most appropriate. The stability statistics generally identified Novosibirskaya 32 as the most stable variety from a biological point of view. The regression approach showed that Novosibirskaya 3 was the genotype with the smallest deviation from mean yield in all environments, while methods accessing the contribution of each genotype to the genotype x environment interaction defined Novosibirskaya 51 as the most stable variety.
Some instances of electron field emitters are characterized by frequency-dependent hysteresis in their current–voltage characteristics. We argue that such emitters can be classified as memristive systems and introduce a general framework to describe their response.

As a specific example of our approach, we consider field emission from a carbon nanotube array. Our experimental results demonstrate a low-field hysteresis, which is likely caused by an electrostatic alignment of some of the nanotubes in the applied field.

We formulate a memristive model of such phenomena, whose results are in agreement with the experimental results.
An inversion of surface waves dispersion curves is a non-unique and ill-conditioned problem. The inversion result has a probabilistic nature, which becomes apparent when simultaneously restoring the shear wave (S-wave) velocity and layer thickness. Therefore, the problem of uncertainty quantification is relevant. Existing methods through deterministic or global optimization approaches of uncertainty quantification via posterior probability density (PPD) of the model parameters are not computationally efficient since they demand multiple solutions of the inverse problem. We present an alternative method based on a multi-layer fully connected artificial neural network (ANN). We improve the current uni-modal approach, which is known from publications, to multi-modal inversion. We use the Cox's and Teague's algorithm to determine optimal parametrization (number of layers) and the ranges of possible model parameters. We uniformly draw training data sets within estimated ranges and train the ANN. Saved ANN's weights map the phase velocity dispersion curves to values of the S-wave velocity and layers thickness. To estimate the uncertainties, we adapt the Monte-Carlo simulation strategy and project onto the resulting velocity model both frequency-dependent data noise and inverse operator errors, which are evaluated by the prediction of the training data set. The proposed combination of surface waves data processing methods, configured with each other, provides a novel surface waves multi-modal dispersion data inversion and uncertainty quantification approach. We first test our approach on synthetic experiments for various velocity models: a positive velocity gradient, a low-velocity layer and a high-velocity layer. This is done considering uni-modal inversion at first and then compared to the multi-modal inversion. Afterwards, we apply our approach to field data and compare resulting models with the body S-wave processing by the generalized reciprocal method (GRM). The experiments show high-potential results - using ANN yields the possibility to accurately estimate PPD of restored model parameters without a significant computational effort. The PPD-based comparison demonstrates advantages of a multi-modal inversion over uni-modal inversion. The trained ANN provides reasonable model parameters predictions and related uncertainties in real-time.
In the scientific experiment, probiotics Vetom 20.76 based on the predatory fungus Arthrobotrys oligospora and Vetom 1 on the basis of live spore-forming bacteria of the Bacillus subtilis DSM 32424 strain, which have anthelmintic, antiviral and antifungal effects, were used.

One control and four experimental groups of 10 goslings each at the age of 1 month were formed according to the principle of analog pairs. The goslings of the experimental groups received Vetom 20.76 in various dosages: young birds of the 1st experimental group – 0.5 μl/kg of live body weight, the 2nd – 1 μl/kg, the 3rd – 2 μl/kg. Goslings of the 4th experimental group were given Vetom 1 at a dose of 50 mg/kg of live body weight. Both drugs were given in the morning with water, once a day for 30 days.

It was established that Preparations Vetom 20.76 in doses of 0.5; 1 and 2 μl/ kg of body weight and Vetom 1 at a dose of 50 mg/kg of body weight have a growth-stimulating effect when given to goslings for 30 days. The growth rate of the experimental birds depended on the dose of the drugs used. Optimal results were obtained with the use of Vetom 20.76 at a dose of 2 μl/ kg of body weight and Vetom 1 at a dose of 50 mg/kg of body weight once a day for 30 days. The average daily gain in live weight of the experimental geese increased in the 3d and 4th experimental groups by 5.24 and 20.60% in the first 15 days of the experiment and by 24.8 and 44.64% during the aftereffect of the drug.
In the rodent liver, hepatocarcinogens inhibit the glucocorticoid induction of several liver‐specific genes, including tyrosine aminotransferase ( TAT ). A distinct positive correlation exists in mice between the extent of inhibition of TAT induction after acute administration of o ‐aminoazotoluene (OAT) and the frequency of liver tumors after chronic exposure to the carcinogen. To elucidate the mechanism of the carcinogenic action, the effects of OAT on the DNA‐binding activity of several transcription factors participating in the glucocorticoid regulation of TAT gene expression were studied. The experimental inbred male mice were sensitive (A/He and SWR/J, tumor induction frequency of 75–100%, TAT induction inhibition of 35–50%) and resistant (CC57BR/Mv and AKR/J, 0–6% and 10–15%, respectively) to OAT. Gel retardation experiments showed that hepatocyte nuclear factor 3 (HNF3)γ DNA‐binding activity was strongly reduced in nuclear extracts from the livers of OAT‐treated A/He and SWR/J mice but only slightly reduced in CC57Br/Mv and AKR/J mice. The DNA‐binding activities of Ets, AP1 family members, and GME binding proteins were unaffected. HNF3γ DNA‐binding activity was reduced by 1 h after OAT administration and remained low for 1 mo, as did inhibition of TAT induction in the liver. These results suggested that the inhibitory effect of OAT on the glucocorticoid induction of TAT is mediated by reduced HNF3γ DNA‐binding activity. © 2001 Wiley‐Liss, Inc.
First observations of the $B^0_s \rightarrow \psi(2S) \eta$, $B^0 \rightarrow \psi(2S) \pi^+ \pi^-$ and $B^0_s \rightarrow \psi(2S) \pi^+ \pi^-$ decays are made using a dataset corresponding to an integrated luminosity of 1.0~$fb^{-1}$ collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV. The ratios of the branching fractions of each of the $\psi(2S)$ modes with respect to the corresponding $J/\psi$ decays are \[ \frac{\mathcal{B}(B^0_s \rightarrow \psi(2S) \eta) }{\mathcal{B}(B^0_s \rightarrow J/\psi \eta)} =0.83\pm0.14\,(stat)\pm0.12\,(syst)\pm0.02\,(\mathcalB}), \] \[ \frac{\mathcal{B}(B^0 \rightarrow \psi(2S) \pi^+ \pi^-)}{\mathcal{B}(B^0 \rightarrow J/\psi \pi^+ \pi^-)} =0.56\pm0.07\,(stat)\pm0.05\,(syst)\pm0.01\,(\mathcal{B}), \] \[ \frac{\mathcal{B}(B^0_s \rightarrow \psi(2S) \pi^+ \pi^-)}{\mathcal{B}(B^0_s \rightarrow J/\psi \pi^+ \pi^-)} =0.34\pm0.04\,(stat)\pm0.03\,(syst)\pm0.01\,(\mathcal{B}), \] where the third uncertainty corresponds to the uncertainties of the dilepton branching fractions of the $J/\psi$ and $\psi(2S)$ meson decays.
The traditional explanation of ATP coupling is based on the raising of the equilibrium constants of the biochemical reactions. But in the frames of the detailed balance, no coupling occurs under thermodynamic equilibrium.

The role of ATP in coupling is not that it provides an increase in the equilibrium constants of thermodynamically unfavorable reactions but that the unfavorable reactions are replaced by other reactions which kinetically are more favorable and give rise to the same products.

The coupling with ATP hydrolysis results in the formation of quasistationary intermediate states.
Data on the contribution of ambulatory blood pressure (ABP) components to the risk of developing atrial fibrillation (AF) are limited.

We prospectively tested the hypothesis that ABP may represent a potentially modifiable risk factor for the development of AF in a European population study.We recorded daytime blood pressure (BP) in 3956 subjects randomly recruited from the general population in five European countries. Of these participants, 2776 (70.2%) underwent complete 24-hour ABP monitoring. Median follow-up was 14 years. We defined daytime systolic BP load as the percentage BP readings above 135 mm Hg. The incidence of AF was assessed from ECGs obtained at baseline and follow-up and from records held by general practitioners and/or hospitals.

Overall, during 58 810 person-years of follow-up, 143 participants experienced new-onset AF. In adjusted Cox models, each SD increase in baseline 24 hours, daytime and night-time systolic BP was associated with a 27% (P=0.0056), 22% (P=0.023) and 20% (P=0.029) increase in the risk for incident AF, respectively. Conventional systolic BP was borderline associated with the risk of AF (18%; P=0.06). As compared with the average population risk, participants in the lower quartile of daytime systolic BP load (38%), the risk was 46% higher (P=0.0094).Systolic ABP is a significant predictor of incident AF in a population-based cohort. We also observed that participants with a daytime systolic BP load >38% had significantly increased risk of incident AF.
Objective: to assess the probability of pathogenic effects OF Il-18 (IL18, IL18R1 and IL18RAP) gene polymorphism on the risk of myocardial infarction in patients with stable coronary heart disease. Materials and methods : the present study was performed with the inclusion of 260 patients with stable coronary heart disease (CHD), residents of the industrial region of Western Siberia. Molecular genetic testing was performed on nine polymorphic sites of il18, IL18R1, IL18RAP genes. Results: associations of polymorphic sites rs13015714 IL18R1 and rs917997 IL18RAP with risks of myocardial infarction were Determined (OR =1.95 (95% CI =1.06-3.58), p =0.029 and OR =2.01 (95% CI =1.11-3.64), p=0.018). Conclusion: to confirm the role of polymorphism IL18, IL18R1, IL18RAP in the pathogenesis of atherosclerosis, prospective monitoring of this group of patients is necessary to identify cases of manifestation of clinical signs in persons with adverse prognosis.
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (Top1) poisons such as topotecan and irinotecan. Herein, we report our work on the synthesis and characterization of new Tdp1 inhibitors that combine the arylcoumarin (neoflavonoid) and monoterpenoid moieties. Our results showed that they are potent Tdp1 inhibitors with IC50 values in the submicromolar range. In vivo experiments with mice revealed that compound 3ba (IC50 0.62 µM) induced a significant increase in the antitumor effect of topotecan on the Krebs-2 ascites tumor model. Our results further strengthen the argument that Tdp1 is a druggable target with the potential to be developed into a clinically-potent adjunct therapy in conjunction with Top1 poisons.
Using a set of microscopic, spectroscopic, and electrochemical methods, a detailed study of the interrelation between the structural and electrochemical properties of the as-prepared nitrogen-containing multi-walled carbon nanotubes (N-MWCNTs) and their modified derivatives is carried out.

It was found that after treatment of nanotubes with hydrochloric acid, their structure is improved by removing amorphous carbon from the outer layers of N-MWCNTs. On the contrary, ion bombardment leads to the formation of vacancy-type structural defects both on the surface and in the bulk of N-MWCNTs. Based on the comparison between cyclic voltammograms of N-MWCNTs treated in HCl and with an ion beam, the peaks on these curves were separated and assigned to specific nitrogen inclusions and OCFGs.

It is shown that the treated nanotubes have an increased specific capacitance (up to 27 F·g−1) compared to the as-prepared nanotubes (13 F·g−1). This is due to an increase in the redox capacitance. It is associated with the reversible Faraday reactions with the participation of electrochemically active pyridinic and pyrrolic nitrogen inclusions and oxygen-containing functional groups (OCFG). It is shown that the rate of redox reactions with the participation of OCFGs is significantly higher than that of reactions with nitrogen inclusions in the pyridinic and pyrrolic forms. Moreover, it was established that treatment of N-MWCNTs in HCl is accompanied by a significant increase in the activity of nitrogen centers, which, in turn, leads to an increase in the rate of redox reactions involving OCFGs. Due to the significant contribution of redox capacitance, the obtained results can be used to develop supercapacitors with increased total specific capacitance.
This article revises the peculiarities of Amir Timur's army tactical peculiarities, as well as their influence on the development of martial art of the Muslim East. It is established that Timur effectively used the mobilization potential of his state. The sedentary population of Chorasa and Transoxiana formed the infantry archery units who were taught to fight under cover of large standing shields - chapars. At the same time, loyal nomad tribes were the source of horse cavalry for the Timur's army. The base of battle formation was represented by a tactical "skeleton" formed of forced kanbuls, powerful advance guard and a reserve (that included elite warriors). Such battle formation allowed Timur to effectively face outflanking and frontal attacks of the enemy. Besides, such battle formation also fit for quick shift from defense to massive counterattack, performed by advance guard and kanbuls projected towards the enemy. The vulnerability of weakened flank corps was partially compensated by using infantry archery units with support of dismounted archers. As a rule, massive archery attack stopped the enemy's attack and provided for counterattack. The organizational and tactical autonomy of kul corps, which could embattle independently even if there was a front breakthrough or encirclement, played an important role. Dismounted, enshielded warriors of the corps could repulse the attacks until the deblocking unit approaches. A fast-moving reserve under Timur's personal command could be used for both repulsing an attack and augmenting the advancing troops.
The article presents the results of studies on the transverse instability of a high-current relativistic electron beam developing in a linear induction accelerator LIA for 5 MeV electron energy, which is created at the BINP SB RAS together with RFNC VNIITF.

These results were obtained using a software package that makes it possible to simulate the dynamics of the instability development, as well as to calculate the increment of this instability averaged over the accelerator length. The package consists of four main parts. The first of them, made on the base of a three-dimensional model of the accelerating module electrodynamic system of the LIA, allows calculating the main characteristics of electromagnetic dipole modes of such a module, the second and third parts are designed to find three-dimensional accelerating electric and focusing magnetic fields, respectively. In the last part of the package, a system of ordinary differential equations is solved that describes both the motion of beam macroparticles in electric and magnetic fields, including the eigenmode fields, and the excitation of the mode fields by the electron beam. The adequacy of the physical models used in the software package was tested by comparing the spectra of field oscillations in the accelerator modules obtained in calculations and recorded in the experiment.

On the base of the data obtained, the main regularities of the transverse beam instability development in the frequency range ∆f = 0.3–1.1 GHz were revealed, and possible methods for suppressing this instability in the LIA were proposed.
The Vlasov-Poisson kinetic equations describe the dynamics of point masses in a self-consistent gravitational field. For example, these equations describe clusters of stars, galaxies or interstellar gas, large-scale processes in the Universe. For stationary solutions to the Vlasov-Poisson kinetic equations, a sufficient stability condition has already been obtained previously. However, it has not been conversed until now (neither for small perturbations, nor, especially, for finite ones).

The Vlasov-Poisson kinetic equations are related to equations of hydrodynamic type, for which, in turn, there are methods for conversing sufficient stability conditions (at least, in the linear approximation). In this paper, absolute instability for spatial dynamic equilibrium states of Vlasov-Poisson gas with respect to small three-dimensional (3D) perturbations will be proved by the direct Lyapunov method.

absolute instability for spatial dynamic equilibrium states of Vlasov-Poisson gas with respect to small three-dimensional (3D) perturbations will be proved