Hengzongshu/ArticleAgent huggingface dataset:
The paper describes experimental results on generation of heterogeneous flows with nanoparticles in a short-duration wind tunnel.

A piston reactor is used as a settling chamber. Nanoparticles of carbon, silicon carbide, and silicon are synthesized in the reactor by the method of adiabatic compression. A method of obtaining particles coated by carbon is described.

A supersonic flow generated by this method can be used for studying gas dynamics of flows containing nanoparticles.
We report on the cryogenic characterization of Red Green Blue - High Density (RGB-HD) SiPMs developed at Fondazione Bruno Kessler (FBK) as part of the DarkSide program of dark matter searches with liquid argon time projection chambers.

A dedicated setup was used to measure the primary dark noise, the correlated noise, and the gain of the SiPMs at varying temperatures. A custom-made data acquisition system and analysis software were used to precisely characterize these parameters.

We demonstrate that FBK RGB-HD SiPMs with low quenching resistance (RGB-HD-LR$_q$) can be operated from 40 K to 300 K with gains in the range $10^5$ to $10^6$ and noise rates on the order of a few Hz/mm$^2$.
Expression of X-linked genes for G6PD and GALA in interspecific hybrids between Microtus arvalis, M. subarvalis and M. kirgisorum voles was studied.

Quantitative predominance of the enzyme activities of M. arvalis over G6PD activity of M. subarvalis and the GALA activity of M. kirgisorum in the female hybrids was shown. The definitive patterns of these enzyme activities was found on day 6·5 of embryonic development.

Non-random inactivation of X-chromosomes derived from M. subarvalis and M. kirgisorum in the interspecific hybrids with M. arvalis is supposed to be the cause of the phenomenon observed. A hypothesis is proposed that there is a connection between the presence of large heterochromatin regions in the X-chromosomes derived from M. subarvalis or M. kirgisorum and the preferential inactivation of these in female hybrids with M. arvalis.
In this manuscript, we introduce a method to measure entanglement of curves in 3-space that extends the notion of knot and link polynomials to open curves. We define the bracket polynomial of curves in 3-space and show that it has real coefficients and is a continuous function of the curve coordinates. This is used to define the Jones polynomial in a way that it is applicable to both open and closed curves in 3-space. For open curves, the Jones polynomial has real coefficients and it is a continuous function of the curve coordinates and as the endpoints of the curve tend to coincide, the Jones polynomial of the open curve tends to that of the resulting knot. For closed curves, it is a topological invariant, as the classical Jones polynomial. We show how these measures attain a simpler expression for polygonal curves and provide a finite form for their computation in the case of polygonal curves of 3 and 4 edges.
The control action of the jet and the near-wall energy sources on the shock wave structure of supersonic flow in a channel to create a transonic region is studied.

Two formulations of the problem are considered. The first of them is based on the unsteady Euler equations and pulse-periodic energy sources, and the second one is based on the unsteady Navier-Stokes equations closed by k-ω SST turbulence model. The combustion of hydrogen, which is supplied from the holes in the channel walls is considered.

The stable mode of flow with the region characterized by transonic velocities arises. The results of calculations for flat and axisymmetric model are presented.
This work is devoted to development of a modular flight controller architecture for a quadcopter. The hardware part of the controller is a single-Board raspberry Pi computer, for developing the software part Robot Operating System (ROS) framework was used. The paper describes the developed architecture, control algorithms, results of flight experiments in the Gazebo physical simulator.
Геологоразведочные работы, проводимые в последнее время по всей Лено-Тунгусской нефтегазоносной провинции, делают исследования карбонатов осинской подсвиты особенно актуальными, поскольку они позволяют установить закономерности образования ловушек углеводородов.

Методы: комплекс ГИС, детальное литолого-седиментологическое описание 90 и 33 м керна соответственно, секвенс-стратиграфический анализ, петрографический анализ 120 образцов и изучение палеонтологических остатков, отобранных из керна скважин Западно-Ярактинской площади.

Проведенный биостратиграфический анализ подтверждает нижнекембрийский возраст. В скважине № 45 обнаружены остатки известковых водорослей Renalcis polymorphum, Renalcis levis, Botomaella zelenovii, Epiphyton zonatum, Epiphyton celsum, Epiphyton scapulum, Chabakovia ramosa, Chabakovia nodosa, а также мелкораковинная фауна Namacalathus sp. В скважине № 361 были обнаружены и определены известковые водоросли Renalcis polymorphum, Renalcis granosus, Renalcis sp., Renalcis levis, Renalcis seriata, Korilophyton sp., Chabakovia sp. и мелкораковинная фауна (SSF) рода Namacalathus sp. Известковые водоросли, изученные из керна скважин, являлись основными рифостроителями раннекембрийских органогенных построек. Для этих организмов характерны небольшие глубины литорали – сублиторали, что хорошо согласуется с результатами проведенного литолого-фациального исследования.
Nowadays the number of electronic devices has increased as well as their complexity. At the same time only few people are reading user guides for these devices. Moreover, in certain cases even no guides are provided by the manufacturer. Therefore there is a large number of cases when people use such devices incorrectly. This issue could be possibly solved with a system automatically recognizing the type of the device. Such system could provide all necessary user information about that device.

This article suggests one of possible implementations of such device type recognition system. It recognizes type of device in an unsupevised way and shows main characteristics and user guides for the recognized gadget. Our approach for constructing such system relies on machine learning methods since greedy search for an object pattern is not efficient, as it was found out by recent scholarly works. Moreover, automatic object patterns classifiers show higher performance in this task and allow to scale the system to various kinds of input data. The algorithms that we are using for object classification are based on feature extraction from an graphical representation of the object look. This representation is usually proposed in an digital photography format.

We consider our study as the first work towards automated defining characteristics of a device based on its graphical representation.
Новосибирский государственный университетНовосибирск, Россия 3 ФЕНОМЕН «ПРОЩАЛЬНЫХ СТИХОВ» В ДЗЭНСКОЙ ТРАДИЦИИС глубокой древности на Востоке с величайшим уважением и трепетом относились к начертаниям кисти, к написанному слову, которое «и есть сам человек» (Tanchu Terayama, 2005.P.7).В неизмеримо большей степени это относится к юигэ -предсмертным строкам, обнажающим, как считалось, саму суть человека.Феномен «прощальных стихов», написанных в последние мгновения жизни, принадлежит к самым волнующим рукописным завещаниям в истории человечества.В статье анализируются отдельные, наиболее репрезентативные, с точки зрения автора, предсмертные строки выдающихся дзэнских наставников, предпринимается попытка исследовать особенность данного феномена, продемонстрировать факт того, что эти последние «следы туши» -отнюдь не произведения искусства, и они не имеют ничего общего с эстетическим опытом.Отсутствие в российском востоковедении исследований на эту тему обеспечивает данной работе определённую значимость и актуальность.
При распараллеливании решения трехмерных краевых задач на квазиструктурированных сетках методом декомпозиции расчетной области на подобласти, сопрягаемые без наложения, наиболее трудоемкой вычислительной процедурой является решение краевых подзадач в подобластях. Использование параллелепипедальных квазиструктурированных сеток дает возможность применить для этих целей быстросходящиеся методы переменных направлений. Распараллеливание итерационного процесса по подобластям проводится на CPU в системе MPI, а для решения подзадач в настоящей статье предлагается использовать графические ускорители GPU. Приводятся экспериментальные исследования применения графических ускорителей при решении подзадач методом Писмана-Речфорда. Даются экспериментальные оценки ускорения распараллеливания в гибридной вычислительной среде CPU+GPU по сравнению с расчетами только на CPU. When parallelizing the solution processes of solving three-dimensional boundary value problems on quasi-structured grids by the method of decomposition of the computational domain into subdomains without imposition, the most time consuming computational procedure is a solution of subproblems in subdomains. The application of parallelepiped quasi-structured grids makes it possible to use the rapidly convergent method of alternating directions. The parallelization of iterative processes on subdomains is performed on CPU using MPI. In order to solve the subproblems, we propose to use the graphics accelerators (GPU). Experimental results of using the graphics accelerators to solve the subproblems by Peaceman-Rachford method are discussed. The computational acceleration achieved on the CPU+GPU hybrid computing environment is experimentally estimated compared to using the CPU only.
Density functional theory was used to investigate structure and properties of polyvinyl alcohol complexes with halides of second group elements XHal 2 (X = Be, Mg, Ca, Zn, Sr, Cd, Ba, and Hg; Hal = F, Cl, Br, and I). PVA can form hybrid interpolymeric complexes with some of them. These complexes show double spiral structure of two types.
We apply a general approach for distributions of binary isolating and semi-isolating formulas to families of isolated types and to the class of countably categorical theories. Containing compositions and Boolean combinations, structures associated with binary formulas linking iso- lated types in general case and for ω-categorical theories are character- ized.
Новосибирский государственный университет Новосибирск, РоссияАннотация В работе рассмотрена трансформация визуального облика гербов рода Датэ на примере письменных и материальных источников.Процесс формирования геральдического наследия этого крупного феодального клана начался сравнительно рано -в конце XII в., и, как и у многих других представителей военного сословия, на протяжении нескольких веков иконография гербов была подвержена постоянным изменениям и относительную стабильность приобрела лишь к середине XIX в.В ходе изучения геральдического наследия этого рода проявился естественный дисбаланс в количестве и качестве исторических источников при изучении более ранних и более поздних геральдических изображений.Нижняя граница хронологических рамок исследования определяется концом XVI -началом XVII в., а верхняя граница -серединой XIX в., поскольку именно этим периодом датируется основной массив известных на данный момент материальных носителей геральдических изображений.Анализ геральдической истории рода Датэ поставил
HYPOTHETICAL MECHANISM OF SPECIATION

A. D. Bazykin Institute of Cytology and Genetics Academy of Sciences of the USSR, Siberian Department

Evolution, Volume 23, Issue 4, 1 December 1969, Pages 685–687
Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33, P = 4.2 × 10(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11, P = 8.7 × 10(-6)) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07-1.23, P = 7.9 × 10(-5)) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene, suggesting that TACC2 is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (P = 2.1 × 10(-3)). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.
Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD).

Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP ( RPS6KA2 ) and DMRs ( VMP1, ITGB2 and TXK ) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci; VMP1/microRNA-21 methylation associates with two polymorphisms in linkage disequilibrium with a known IBD susceptibility variant. Separated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8 + T cells, but not other cell types.

Thus, site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression.
The paper presents numerical simulation of the flow in hydraulic turbine based on the experimental data of the II Francis-99 workshop.

The calculation domain includes the wicket gate, runner and draft tube with rotating reference frame for the runner zone. Different turbulence models such as k-ω SST, ζ-f and RSM were considered. The calculations were performed by means of in-house CFD code SigmaFlow.

The numerical simulation for part load, high load and best efficiency operation points were performed.
The most interesting experimental results obtained in studies of 2D and 3D topological insulators (TIs) based on HgTe quantum wells and films are reviewed. In the case of 2D TIs, these include the observation of nonlocal ballistic and diffusion transport, the magnetic breakdown of 2D TIs, and an anomalous temperature dependence of edge-channel resistance. In 3D TIs, a record-setting high mobility of surface two-dimensional Dirac fermions (DFs) has been attained. This enabled determining all the main TI parameters (the bulk gap and the density of DFs on both of its surfaces) and provided information on the phase of the Shubnikov - de Haas oscillations of DFs, which indicates the rigid topological coupling between the fermion spin and momentum. Prospects for further research are discussed in the conclusion.
Ca,Mg-sulfates are subduction-related sources of oxidized S-rich fluid under lithospheric mantle P,T-parameters. Experimental study, aimed at the modeling of scenarios of S-rich fluid generation as a result of desulfation and subsequent sulfide formation, was performed using a multi-anvil high-pressure apparatus. Experiments were carried out in the Fe,Ni-olivine–anhydrite–C and Fe,Ni-olivine–Mg-sulfate–C systems (P = 6.3 GPa, T of 1050 and 1450 °C, t = 23–60 h). At 1050 °C, the interaction in the olivine–anhydrite–C system leads to the formation of olivine + diopside + pyrrhotite assemblage and at 1450 °C leads to the generation of immiscible silicate-oxide and sulfide melts. Desulfation of this system results in the formation of S-rich reduced fluid via the reaction olivine + anhydrite + C → diopside + S + CO2. This fluid is found to be a medium for the recrystallization of olivine, extraction of Fe and Ni, and subsequent crystallization of Fe,Ni-sulfides (i.e., olivine sulfidation). At 1450 °C in the Ca-free system, the generation of carbonate-silicate and Fe,Ni-sulfide melts occurs. Formation of the carbonate component of the melt occurs via the reaction Mg-sulfate + C → magnesite + S. It is experimentally shown that the olivine-sulfate interaction can result in mantle sulfide formation and generation of potential mantle metasomatic agents—S- and CO2-dominated fluids, silicate-oxide melt, or carbonate-silicate melt.
The heat transfer in a shear driven rivulet flow at isothermal conditions in a minichannel has been studied. The experiments were conducted using the setup, specially designed for the shear driven rivulet flow. The effect of liquid flow rate and substrate temperature on the width of the rivulet was studied experimentally using Laser induced fluorescence technique (LIF). The temperature distribution for different time moments of the rivulet surface was measured by the FLIR infrared (IR) camera. IR-measurements served to demonstrate that rivulet surface temperature is lower than substrate one due to liquid evaporation from the rivulet surface.
In this paper the problems of recognizability and strong recognizavility, perceptibility and strong perceptibility in extensions of the minimal Johansson logic J [1] are studied.These concepts were introduced in [2, 3, 4].Although the intuitionistic logic Int is recognizable over J [2], the problem of its strong recognizability over J is not solved.Here we prove that Int is strong recognizable and strong perceptible over the minimal pre-Heyting logic Od and the minimal well-composed logic JX.In addition, we prove the perceptibility of the formula F over JX.It is unknown whether the logic J+F is recognizable over J.
Glioblastoma is a highly lethal brain cancer. Virotherapy with the use of oncolytic viruses has since recently been regarded as a promising approach for the clinic treatment of human glioblastomas.

The purpose of this work was to perform a primary evaluation of the Zika virus as a potential oncolytic agent against glioblastomas. In vitro experiments showed that the Zika virus strain MR 766 is able to selectively infect and lyse neoplastic cells of the human glioblastoma cell line U87 MG. The selectivity index (SI, the ratio of infectious titer for tumor cells to titer on normal untransformed cells) was 2·102. The selectivity of the replicative activity of Zika virus in relation to U87 MG glioblastoma cells was additionally confrmed by indirect immunoﬂuorescence. Using the model of immunodefcient SCID mice with subcutaneous xenografts of human glioblastoma U87 MG, a strong antitumor activity of the Zika virus under a course (daily for 4 days) of intratumoral administration of 5·105 TCID50 of Zika virus was shown.

Treatment with Zika virus resulted in more than a 10­fold reduction in mean volumes of tumors. The tumor growth inhibition index was 92.63 %. Recurrences (metastases) of tumor re­growth were not registered within 64 days of observation. This result demonstrated the prospect of further in­depth studies of the Zika virus as a potential oncolytic agent against human glioblastomas.
Providing users with the way to collaboratively edit shared model is the challenge of complex informational systems. The majority of existing methods require online connection between users, otherwise, users’ intentions can be lost after a certain delay. The aim of this research is to build a collaborative system that allows users to edit shared model in offline manner without losing their intentions. Firstly, commit-based system was selected as underlying data storage. Secondly, we examined existing collaborative algorithms and selected operational transformation as the most perspective for this scenario. Thirdly, we described the way to merge commits, that stores operations, using modified operational transformation algorithm. Key features of modified operational transformation algorithm include ability to handle resolving of merge conflicts, when intentions of two users are conflicting. To implement this, we consider the set of commits branches as ordered set. As a result, we developed a version control system, that stores user’s intentions and can automatically resolve conflicts on merge. This approach can be applied to any informational system, which is able to save user’s input as the set of operations.
Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior.

Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research.

Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data in sufficiently sized and independent data sets are needed to assess whether these loci represent genuine MS risk factors.

The lead SNPs of all 11 loci were genotyped in 10 796 MS cases and 10 793 controls from Germany, Spain, France, the Netherlands, Austria and Russia, that were independent from the previously reported cohorts. Association analyses were performed using logistic regression based on an additive model. Summary effect size estimates were calculated using fixed-effect meta-analysis.

Seven of the 11 tested SNPs showed significant association with MS susceptibility in the 21 589 individuals analysed here. Meta-analysis across our and previously published MS case-control data (total sample size n=101 683) revealed novel genome-wide significant association with MS susceptibility (p<5×10−8) for all seven variants. This included SNPs in or near LOC100506457 (rs1534422, p=4.03×10−12), CD28 (rs6435203, p=1.35×10−9), LPP (rs4686953, p=3.35×10−8), ETS1 (rs3809006, p=7.74×10−9), DLEU1 (rs806349, p=8.14×10−12), LPIN3 (rs6072343, p=7.16×10−12) and IFNGR2 (rs9808753, p=4.40×10−10). Cis expression quantitative locus effects were observed in silico for rs6435203 on CD28 and for rs9808753 on several immunologically relevant genes in the IFNGR2 locus. This study adds seven loci to the list of genuine MS genetic risk factors and further extends the list of established loci shared across autoimmune diseases.
This paper deals with the combined approach to describing the evolution of weakly nonlinear three-dimensional moderately long perturbations of free surface of viscous liquid.

The initial system of hydrodynamic equations is reduced to the novel model system of equations. The first of them is integro-differential equation for nonlinear perturbation of the free surface, taking into account non-stationary shear stress on a weakly sloping bottom. Another equation is an auxiliary linear equation for determining the liquid horizontal velocity vector, averaged over the layer depth. This vector is present in the main equation only in the term of the second order of smallness.

The proposed model is suitable for finite-amplitude waves, traveling in different directions in the horizontal plane. Some problems of interactions and collisions of such perturbations over the horizontal and weakly sloping bottom are solved numerically.