Hengzongshu/ArticleAgent huggingface dataset:
N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first time data on the frequency of two important "slow" variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia. The aim of this study was to identify the frequencies of these variants and compare them with frequencies in other ethnic populations.NAT2*5 (T341C) genotyping revealed frequencies of 28,0% and 38,6% for Tundra and Forest Nenets, respectively. The frequencies of NAT2*7 (G857A) variant were 9,8% and 8,2% for Tundra and Forest Nenets, respectively. Polymorphic variants frequencies for Nenets are intermediate between those in populations of Europeans and Asians. These results can probably be explained by the presence of both European and Asian components in Nenets gene pools.The results of this study expand the knowledge of NAT2 polymorphism in world populations. These data may also help assess the genetic predisposition of Nenets to multifactorial diseases associated with polymorphism in the NAT2 gene and, in general, contribute to the development of personalized medicine in reference to native people of Siberia.
This is data on the microbial diversity in the floating cyanobacterial community and sediment samples from the lake Solenoe (Novosibirsk region, Russia) obtained by metagenomic methods. Such a detailed data of the microbial diversity of the Novosibirsk oblast lake ecosystem was carried out for the first time. The purpose of our work was to reveal microbial taxonomic diversity and abundance, metabolic pathways and new enzyme findings the studied lake ecosystem using the next-generation sequencing (NGS) technology and metagenomic analysis. The data was obtained using metagenomics DNA whole genome sequencing (WGS) on Illumina NextSeq and NovaSeq. The raw sequence data used for analysis is available in NCBI under the Sequence Read Archive (SRA) with the BioProjects and SRA accession numbers: PRJNA493912 (SRR7943696), PRJNA493952 (SRR7943839) and PRJNA661775 (SRR12601635, SRR12601634, SRR12601633) corresponding to floating cyanobacterial community and sediment layers samples, respectively.
We would like to thank the staff of participating clinics for their help in collecting biosamples and clinical information. This work was supported by the Russian Science Foundation [Project No 17-75-20223]. The work of Dr Tsepilov was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Programme. We express our gratitude to the members of the Gene ATLAS project (http://geneatlas.roslin.ed.ac.uk/) and personally thank the Albert Tenesa's group, Oriol Canela-Xandri, and Konrad Rawlik for sharing UK Biobank GWAS summary statistics that we have used in our study. We gratefully thank UK Biobank for establishing a powerful resource for genetic and epidemiological studies. The authors wish to correct the information in the Acknowledgement section in their paper.
Most copy number variations (CNVs) in the human genome display incomplete penetrance with unknown underlying mechanisms. One such mechanism may be epigenetic modification, particularly DNA methylation. The IMMP2L gene is located in a critical region for autism susceptibility on chromosome 7q (AUTS1).

The level of DNA methylation was assessed by bisulfite sequencing of 87 CpG sites in the IMMP2L gene in 3 families with maternally inherited 7q31.1 microdeletions affecting the IMMP2L gene alone. Bisulfite sequencing revealed comparable levels of DNA methylation in the probands, healthy siblings without microdeletions, and their fathers. In contrast, a reduced DNA methylation index and increased IMMP2L expression were observed in lymphocytes from the healthy mothers compared with the probands. A number of genes were upregulated in the healthy mothers compared to controls and downregulated in probands compared to mothers.

These genes were enriched in components of the ribosome and electron transport chain, as well as oxidative phosphorylation and various degenerative conditions. Differential expression in probands and mothers with IMMP2L deletions relative to controls may be due to compensatory processes in healthy mothers with IMMP2L deletions and disturbances of these processes in probands with intellectual disability. The results suggest a possible partial compensation for IMMP2L gene haploinsufficiency in healthy mothers with the 7q31.1 microdeletion by reducing the DNA methylation level. Differential DNA methylation of intragenic CpG sites may affect the phenotypic manifestation of CNVs and explain the incomplete penetrance of chromosomal microdeletions.
A metallic nanoparticle (NP) located near the film acts as a nanoantenna. Surface plasmons, excited by light in a particle and in a film, transform the electromagnetic field, confine it and strongly amplify it in the gap between the particle and the film. The enhancement of the field depends on many factors: the size and shape of NP, the permeability of all materials, the wavelength of light, the thickness of the film, the angle of the light beam and very much from the gap between the particle and the film. The amplification of the field in a narrow gap (~ 1 nm) can be 10^3 or more and the enhancement of Raman radiation can reach enormous values of ~ 10^10–10^11.
In previous studies, we described a method for detecting and typing malignant tumors of the thyroid gland in fine-needle aspiration biopsy samples via analysis of a molecular marker panel (normalized HMGA2 mRNA level; normalized microRNA-146b, -221, and -375 levels; mitochondrial-to-nuclear DNA ratio; and BRAFV600E mutation) in cytological preparations by quantitative PCR. In the present study, we aimed to estimate the specificity of the typing of different thyroid tumors by the proposed method. Fine-needle aspiration cytological preparations from 278 patients were used. The histological diagnosis was known for each sample. The positive and negative predictive values of the method assessed in this study were, respectively, 100% and 98% for papillary thyroid carcinoma (n = 63), 100% and 100% for medullary thyroid carcinoma (n = 19), 43.5% and 98% for follicular carcinoma (n = 15), and 86% and 100% for Hürthle cell carcinoma (n = 6). Thus, we demonstrate that the diagnostic panel, including the analysis of microRNA expression, mRNA expression, the BRAFV600E mutation, and the mitochondrial-to-nuclear DNA ratio, allows the highly accurate identification of papillary thyroid carcinoma, medullary thyroid carcinoma, and Hürthle cell carcinoma but not malignant follicular tumors (positive predictive value was below 50%).
Tetranuclear lanthanide aqua hydroxo complexes with two structural types of core – {Ln 4 (μ 3 ‐OH) 4 (μ 2 ‐OH) 4 } 4+ [Ln = Pr ( 1 ), Nd ( 2 ), Eu ( 3 ), Gd ( 4 ), Tb ( 5 )] and {Ln 4 (μ 3 ‐OH) 4 (μ 2 ‐OH) 2 } 6+ [Ln = Er ( 6 ), Yb ( 7 )] – were prepared by heating (130 °C) of aqueous solutions of lanthanide(III) chlorides, cucurbit[6]uril (C 36 H 36 N 24 O 12 , CB[6]), and 4‐cyanopyridine.

The formation of Ln 4 complexes results from the combined influence of the tetradentate coordination of the polycation by the portals of the macrocyclic ligand CB[6] and the chelating effect of the carboxylate ligands of isonicotinic acid generated as a result of hydrolysis of 4‐cyanopyridine. X‐ray diffraction analysis of 1 – 7 revealed the sandwich structure with the tetranuclear lanthanide complex situated between two macrocyclic molecules. The compounds were characterized by elemental analysis, IR, and electrospray ionization (ESI) mass spectrometry.

Luminescence spectra of 3 and 5 and magnetic properties of 4 were also studied.
The differential evolution algorithm is applied to solve the optimization problem to reconstruct the production function (inverse problem) for the spatial Solow mathematical model using additional measurements of the gross domestic product for the fixed points.

Since the inverse problem is ill-posed the regularized differential evolution is applied. For getting the optimized solution of the inverse problem the differential evolution algorithm is paralleled to 32 kernels.

Numerical results for different technological levels and errors in measured data are presented and discussed.
In the following article, we classify the typical existential-spatial syntactic structures in two Khanty dialects (Kazym and Surgut) and two Nenets dialects (Forest and Tundra). We distinguish two classes of elementary simple sentences corresponding to one proposition: static, or existential-locative, denoting an un-changing state of an object in space, and dynamic, denoting transition from one point to another. Each of these classes contains causative variants denoting causa-tion of location (who keeps what and where) and causation of movement, or transition (who moves what and where), which are represented by non-elementary simple sentences. Khanty and Nenets, as well as their dialects, differ by how they represent spatial relations: in Khanty, analytical means (postpositions and preverbs) prevail, whereas in Nenets, synthetic means (case markers) are more common. Existential-spatial relations are expressed by the following means: adverbs, postpositions, case markers, preverbs (the latter are unique for Ugric languages). Kazym dialect of the Khanty language has a reduced case system, in which two cases are contrasted, namely locative-instrumental and dative-directional, expressing static and dynamic spatial relations. In the Surgut dialect, there are two com-peting directional cases, as well as locative and ablative. In Nenets, there is a case system where each spatial case denotes a certain type of spatial relations: place, direction, starting point, and route. Correspondingly, in Kazym dialect, one mostly finds analytical means of expression of spatial relations; postpositions and preverbs are more frequent than in other Khanty and Nenets dialects analyzed in our work. component structure and leads to clearing of an internal form at his expansion, and sometimes serves as attempt of national and etymological decoding of an image. The semantic redundancy, a pleonasm inherent in some turns with components distributors. In some cases the specifying component can provoke semantic shifts of phraseological units or promote representation of other mental installations. The practical value of comparison of dialect and all-Russian constructive options (except conclusions about structural-semantic and figurative and pragmatical properties of phraseological units) consists in a possibility of specification of historical and etymological versions and clearings of a phraseological image.
This essay is about superluminal motion. It is generally believed that special relativity prohibits movements faster than the speed of light. It is explained which motion is actually forbidden by special relativity and why. Tachyons are breafly discussed and it is explained that, due to internal instability, tachyon fields cannot be used to transmit information faster than the speed of light. However, as John Stuart Bell remarked, “what is proved by the impossibility proofs is lack of imagination”. Inspired by the Frenkel–Kontorova model of crystal dislocations, we demonstrate the way to overcome the light speed barrier by introducing elvisebrions. Elvisebrions are defined as objects that can exist in the case when some hidden sectors, very weakly interacting with the visible sector, are either not Lorentz invariant, or Lorentz invariant but with different limiting velocities. In this case, elvisebrions can move in a superluminal manner without violating our existing physical models.
Here, we demonstrate bioconversion of methane to muconic acid, a dicarboxylic acid that can be upgraded to an array of platform chemicals, by three gammaproteobacterial methanotrophs.
In this article, we briefly summarize the experiments performed during the first Run of the Advanced Wakefield Experiment, AWAKE, at CERN (European Organization for Nuclear Research). The final goal of AWAKE Run 1 (2013 - 2018) was to demonstrate that \unit[10-20]{MeV} electrons can be accelerated to GeV-energies in a plasma wakefield driven by a highly-relativistic self-modulated proton bunch. We describe the experiment, outline the measurement concept and present first results. Last, we outline our plans for the future.
Angular correlations in ${B}^{+}\ensuremath{\rightarrow}X(3872){K}^{+}$ decays, with $X(3872)\ensuremath{\rightarrow}{\ensuremath{\rho}}^{0}J/\ensuremath{\psi}$, ${\ensuremath{\rho}}^{0}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ and $J/\ensuremath{\psi}\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$, are used to measure orbital angular momentum contributions and to determine the ${J}^{PC}$ value of the $X(3872)$ meson.

The data correspond to an integrated luminosity of $3.0\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of proton-proton collisions collected with the LHCb detector.

This determination, for the first time performed without assuming a value for the orbital angular momentum, confirms the quantum numbers to be ${J}^{PC}={1}^{++}$. The $X(3872)$ is found to decay predominantly through an S wave and an upper limit of 4% at 95% C.L. is set on the D-wave contribution.
Empedocles uses two forces to describe the world process, the emergence and destruction of space - Love and Strife, which work in turn, and in due time, replace each other. It is obvious that love is responsible for unification and creation, and hostility for division and destruction. At first glance it seems quite natural that it is the power of unification that Empedocles calls Aphrodite. However, when you look closely at the fragments of the poem, the image of Aphrodite is not so unambiguous: she acts as a god-craftsman, that is, not just watches from afar as the roots of things are connected to each other, but mixes them with her own hands and is directly involved in the creation of living beings. We meet her involved in such activities as metal casting, pottery, and artwork.

To answer this question, one should turn to literary sources about Aphrodite both before and after Empedocles’ life (in the context of Homer’s epos and Hesiod’s poem), consider the religious tradition of Cyprus and especially the East, neighboring Greece, from where, in the opinion of some scientists, the goddess could get into the Mediterranean cultural landscape (most important study here is the work by Nano Marinatos), to study archaeological data and findings related to Aphrodite. Taking into account Empedocles’ interest to bloodless sacrifices I will try to tie his views with the later orphic tradition. At the same time, in order to protect myself from losing the way in the forest of such huge massif it is necessary to restrict the area of this study.

I will concentrate only on the activities of Aphrodite as she is presented in Empedocles.
Aim . To study association between polymorphisms of candidate genes and the development of non-infectious and infectious endocarditis (IE).

Material and methods . During the study 175 patients were examined. They were divided into two groups: the first group — 81 patients with non-infectious endocarditis and the second one — 94 patients with IE. We present a comparative analysis of the genotype frequencies of the five genes polymorphisms: rs11697325 (-8202 A/G) of the MMP9 gene, 4a/4b of the NOS3 gene, rs4340 of the ACE gene, rs2476601 (С1858Т) of the PTPN22 gene, rs231775 (49 A/G) of the CTLA4 gene in groups of patients with endocarditis and healthy individuals.

Results . We found association between endocarditis and rs11697325 (-8202 A/G) of the MMP9 gene, 4a/4b of the NOS3 gene, as well as rs2476601 (C1858T) of the PTPN22 gene with IE. Conclusion . Thus, association between three of the five polymorphisms and vegetations on the valvular heart apparatus was revealed.
extending the results of Honkapohja and Mitra (2006), Kolyuzhnov (2011), and Bogomolova and Kolyuzhnov (2019)

Sufficient conditions for stability under heterogeneous mixed RLS/SG learning for four classes of models: models without lags and with lags of the endogenous variable and with t or t-1- dating of expectations, are provided for the cases of the diagonal structure of the shock process behaviour or the heterogeneous RLS learning and are presented in terms of structural heterogeneity and are independent of heterogeneity in learning. The results are based on the negative diagonal dominance approach and are provided, first, in terms of the existence of the weights for aggregation of endogenous variables and of expectations across agents, interrelated in a special way

The fundamental nature of the approach adopted in the paper allows one to apply its results to a vast majority of the existing and prospective linear and linearized economic models (including estimated DSGE models) with adaptive learning of agents
Experimental data on the development of controlled disturbances in the boundary layer with a longitudinal vortex are analysed. It is found experimentally that the mean flow nonuniformity can vary from 0.7 to 0.9 V in terms of the CTA mean voltage or 30–40% in ρU. Such flow nonuniformity complicates the estimation of the wave spectra, where normalization on the mean voltage of the anemometer is required. The applicability of the standard processing procedure is investigated. Comparative analysis of the data shows that both normalization types considered in the work can be applicable. However, in the case of flow nonuniformity in the transverse direction, it is preferable to use the normalization on the median value over the mean voltage spanwise distribution.
Presented paper contains results of a numerical analysis of experiments with gas injection in water and liquid metal which have been performed at the Institute of Thermophysics Russian Academy of Science (IT RAS). Obtained experimental data are very important to predict processes that take place in the BREST-type reactor during the hypothetical accident with damage of the steam generator tubes, and may be used as a benchmark to validate thermo-hydraulic codes. Detailed description of models to simulate transport of gas phase in a vertical liquid column is presented in a current paper. Two-fluid model with closing relation for wall friction and interface friction coefficients was used to simulate processes which take place in a liquid during injection of gaseous phase. It has being shown that proposed models allow obtaining a good agreement between experimental data and calculation results.
Association between common intelligence quotient (IQ) and S and L alleles of functional 5HTTLPR polymorphism causing respectively low and high expression of human serotonin transporter coding gene was studied

in young (19-35 years, 50 men and 76 women) and older (>55 years, 39 men and 43 women) Caucasian subjects.They were students, scientists, technicians and administrative staff of Novosibirsk State Universities and State Research Institutes of Russian Academy of Sciences.Significant effects of genotype and age, but not gender on IQ were revealed.Higher IQ scores were observed in the S/S genotype carriers compared with the L/S (p<0.002) or L/L (p<0.003)genotype carriers.No effect of the genotype x gender or genotype x age interaction was found.Based on this result, we hypothesized an increased frequency of the S allele in highly educated university group compared with control population.To test this hypothesis the distribution of the alleles and genotypes in the above mentioned academic sample and control population of Caucasian subjects from Dovolnoe village, Novosibirsk region (n=83) was compared.

The frequencies of the S allele (43.5%) and the S/S genotype (20.5%) in the academic sample were significantly higher than in the controls (28.2%, p=0.023 for the S allele and 10.1%, p=0.011 for the S/S genotype).The results indicate a significant association between IQ scores and the 5HTTLPR polymorphism, the involvement of serotonergic neuromodulation in cognitive functioning and provide further support for the classification of the S allele and the S/S genotype as associated with cognition.
Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device.

Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration.

Use of this open science model attracts contributions from users and developers outside the 'core team', facilitating agile statistical omics methodology development and fast dissemination.
In the case of small Reynolds numbers for long wave perturbations

wave modes are modeled for a countercurrent flow of vertically falling liquid film and turbulent gas. the problem is reduced to a nonlinear integro-differential equation for the film thickness deviation from the undisturbed level

Solutions of this model equation are studied. Several typical scenarios for the evolution of periodic perturbations are presented
A new Python-based Particle-In-Cell code is presented. The code uses leapfrog particle pusher. The important feature of our code is that all the particles are pushed at once, thus the code is vectorized to improve performance. Electric field is given by Poisson equation with Least squares solver. The code involves collision simulation by PIC-MC method. Both large-scale (MPI) and fine-grain parallelization are being used. The implementation is based on the efficient NumPy library in Python language with the help of Dask package to improve Numpy performance. GPU implementation involves PyCUDA and the performance with Intel Xeon processors and Intel Xeon Phi accelerators is supported by high-performance Intel Python.