Hengzongshu/ArticleAgent huggingface dataset:
We have characterized the human cell line arised from the Epstein–Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation. This cell line has acquired the ability to form free-floating spheres and to produce a xenograft upon transplantation into NOD/SCID mice.

Cells from both in vitro culture and developed xenografts were investigated with a number of analytical approaches, including pathomorphological analysis, FISH analysis, and analysis of the surface antigens and of the VDJ locus rearrangement. Next we assessed whether cells that (i) were constantly present in vitro in the investigated cell line, (ii) were among the sphere-forming cells, and (iii) were capable of internalizing a fluorescent TAMRA-labeled DNA probe (TAMRA+ cells) belonged to one of the three types of undifferentiated bone marrow cells of a multiple myeloma patient: CD34+ hematopoietic stem cells, CD90+ mesenchymal stem cells, and clonotypic multiple myeloma cell.

The obtained results, as well as the confirmed presence of EBV, testify that both biological systems are derived from B-cells, which, in turn, is a progeny of the EBV-transformed B-cellular clone that supplanted the primordial multiple myeloma cells. TAMRA+ cells were shown to constitute the fourth independent subpopulation of undifferentiated bone marrow cells of the multiple myeloma patient. We have demonstrated the formation of ectopic contacts between TAMRA+ cells and cells of other types in culture, in particular with CD90+ mesenchymal stem cells, followed by the transfer of some TAMRA+ cell material into the contacted cell.
By a graph we mean a finite connected multigraph without bridges. The genus of a graph is the dimension of its homology group. Two graphs are isospectral is they share the same Laplacian spectrum. We prove that two genus two graphs are isospectral if and only if they are isomorphic. Also, we present two bridgeless genus three graphs that are not isomorphic. The paper is motivated by the following open problem posed by Peter Buser: are isospectral Riemann surfaces of genus two isometric?
Long-range interactions between cold Rydberg atoms are being investigated for neutral-atom quantum computing, quantum simulations, phase transitions in cold Rydberg gases and other applications.

Fine tuning of the interaction strength can be implemented using Förster resonances between Rydberg atoms controlled by an electric field. The observation of the Stark-tuned Förster resonances between Rydberg atoms excited by narrowband cw laser radiation requires usage of a Stark-switching technique in order to excite the atoms first in a fixed electric field and then to induce the interactions in a varied electric field, which is scanned across the Förster resonance. The application of the radio-frequency field causes additional Förster resonances between collective states, whose line shape depends on the interaction strengths and time.

Spatial averaging over the atom positions in a single interaction volume yields a cusped line shape of the Förster resonance. We present a detailed experimental and theoretical analysis of the line shape and time dynamics of the Stark-tuned Förster resonances Rb(nP3/2) + Rb(nP3/2) → Rb(nS1/2) + Rb([n + 1]S1/2) for two Rb Rydberg atoms interacting in a time-varying electric field.
A subgroup H of a group G is said to be pronormal in G if H and Hg are conjugate in for every g \in G. Some problems in finite group theory, combinatorics, and permutation group theory were solved in terms of pronormality. In 2012, E. Vdovin and the third author conjectured that the subgroups of odd index are pronormal in finite simple groups. In this paper we disprove their conjecture and discuss a recent progress in the classification of finite simple groups in which the subgroups of odd index are pronormal.
Mesozoic (125–135 Ma) cratonic low-Ti lamproites from the northern part of the Aldan Shield do not conform to typical classification schemes of ultrapotassic anorogenic rocks. Here we investigate their origins by analyzing olivine and olivine-hosted inclusions from the Ryabinoviy pipe, a well preserved lamproite intrusion within the Aldan Shield. Four types of olivine are identified: (1) zoned phenocrysts, (2) high-Mg, high-Ni homogeneous macrocrysts, (3) high-Ca and low-Ni olivine and (4) mantle xenocrysts. Olivine compositions are comparable to those from the Mediterranean Belt lamproites (Olivine-1 and -2), kamafugites (Olivine-3) and leucitites. Homogenized melt inclusions (MIs) within olivine-1 phenocrysts have lamproitic compositions and are similar to the host rocks, whereas kamafugite-like compositions are obtained for melt inclusions within olivine-3. Estimates of redox conditions indicate that “lamproitic” olivine crystallized from anomalously oxidized magma (∆NNO +3 to +4 log units.). Crystallization of “kamafugitic” olivine occurred under even more oxidized conditions, supported by low V/Sc ratios. We consider high-Ca olivine (3) to be a fingerprint of kamafugite-like magmatism, which also occurred during the Mesozoic and slightly preceded lamproitic magmatism. Our preliminary genetic model suggests that low-temperature, extension-triggered melting of mica- and carbonate-rich veined subcontitental lithospheric mantle (SCLM) generated the kamafugite-like melts. This process exhausted carbonate and affected the silicate assemblage of the veins. Subsequent and more extensive melting of the modified SCLM produced volumetrically larger lamproitic magmas. This newly recognized kamafugitic “fingerprint” further highlights similarities between the Aldan Shield potassic province and the Mediterranean Belt, and provides evidence of an overlap between “orogenic” and “anorogenic” varieties of low-Ti potassic magmatism. Moreover, our study also demonstrates that recycled subduction components are not an essential factor in the petrogenesis of low-Ti lamproites, kamafugites and leucitites.
The notion of a derivation with invertible values as a derivation of ring with unity that only takes multiplicatively invertible or zero values appeared in a paper of Bergen, Herstein and Lanski, in which they determined the structure of associative rings that admit derivations with invertible values. Later, the results of this paper were generalized in many cases, for example, for generalized derivations, associative superalgebras, alternative algebras and many others.

The present work is dedicated to the description of all Jordan algebras admitting derivations with invertible values.
Машиностроение Сибири: возможности развития в условиях современных вызовов Л. С. Веселая, В
The numerical simulation of wavy regimes of the freely-falling liquid film was realized using the previously discovered symmetry of model equations.

The calculation results are presented for the dynamics of amplitudes of significant harmonics and for the wave surface evolution.

The paper has resulted in finding a specific regime, characterized by an alternate predominance of the first and second harmonics. At certain values of parameters this limiting cycle may have a very large period, during which the solution is attracted to the quasi-steady-state traveling regime, then suddenly transforms, and again tends to the quasi-steady-state with a phase shift of a half wave length.
Using bioinformatics analysis we selected microRNAs which could bind 3'-UTR-region of cytochrome P450 (CYP) genes. Three microRNA miR-21, -221, -222, their potential targets might be mRNA for CYP1A1, and two microRNA miR-143, miR-152 for CYP2B1 accordingly were selected for experimental verification.

Expression level of these microRNAs in rat liver upon benzo(a)pyrene (BP), phenobarbital (PB), and DDT induction was determined using RT-qPCR method. In rats treated by both BP, and DDT the hepatic content of miR-21, -221, -222 significantly demonstrated a 2-3-fold decrease. The decrease in miR expression was accompanied by a considerable (5.5-8.7-fold) increase in the CYP1A1-mediated EROD activity. The expression of miR-143 remained unchanged after the PB treatment, while the expression of miR-152 increased by 2 times, however, the (10.5-fold) increase in PROD activity of CYP2B was much higher. In the DDT-treated liver PROD activity increased by 20 times, the expression of miR-152 didn't change, and the expression of miR-143 increased by 2 times.

The bioinformatics analysis of interactions between microRNAs and targets showed that the studied miRs can potentially bind 3'-end of AhR, ESR1, GR, CCND1, PTEN mRNA. Thus, the expression profile of miR-21, -221, -222, -143, -152 might change under the xenobiotics exposure. In silico analysis confirmed, that microRNAs target not only cytochrome P450 mRNA but also other genes, including those involved in hormonal carcinogenesis, they also can be regulated with studied miRs
Gas-liquid two-phase bubbly flows are found in different areas of science and technology such as nuclear energy, chemical industry, or piping systems. Optical diagnostics of two-phase bubbly flows with modern panoramic techniques makes it possible to capture simultaneously instantaneous characteristics of both continuous and dispersed phases with a high spatial resolution. In this paper, we introduce a novel approach based on neural networks to recognize bubble patterns in images and identify their geometric parameters. The originality of the proposed method consists in training of a neural network ensemble using synthetic images that resemble real photographs gathered in experiment. The use of neural networks in combination with automatically generated data allowed us to detect overlapping, blurred, and non-spherical bubbles in a broad range of volume gas fractions. Experiments on a turbulent bubbly jet proved that the implemented method increases the identification accuracy, reducing errors of various kinds, and lowers the processing time compared to conventional recognition methods. Furthermore, utilizing the new method of bubbles recognition, the primary physical parameters of a dispersed phase, such as bubble size distribution and local gas content, were calculated in a near-to-nozzle region of the bubbly jet. The obtained results and integral experimental parameters, especially volume gas fraction, are in good agreement with each other.
Damage of divertor tungsten tiles as a result of transient plasma processes is one of the key problems of the ITER tokamak. Even if the temperature of the divertor tiles is maintained below the melting threshold, their thermal deformation, accumulation of residual stresses and cracking will occur. Cracking reduces the resistance of the metal to subsequent loads, therefore, the study of this process is important. In materials science, non-destructive methods for measuring mechanical stresses are very limited. In this work, a new method is proposed that allows non-contact investigation of stresses in polycrystalline tungsten plates by their bending. A corresponding diagnostic system and theoretical model are implemented. A number of experiments were carried out using this diagnostic system at the BETA facility at the Budker Institute to study the dynamics of tungsten plates bending with different thickness, subjected to pulsed heating of different intensities. The experimental results showed the qualitatively expected process of the plate bending, as well as good agreement with the theoretical model. This proved that the method described in the work is promising for use in order to study the residual stresses in a pulse-heated metal sample.
Denote the alternating and symmetric groups of degree [Formula: see text] by [Formula: see text] and [Formula: see text], respectively.

Consider a permutation [Formula: see text], all of whose nontrivial cycles are of the same length.

We find the minimal polynomials of [Formula: see text] in the ordinary irreducible representations of [Formula: see text] and [Formula: see text].
Microinclusions in cuboid diamonds represent the mantle-derived fluid or melt from which they crystallized. The low degree of N aggregation in diamonds with microinclusions (cuboid or coated diamonds) indicates a short mantle residence and suggests that they crystallized shortly before kimberlite eruption.

New data on the composition of microinclusions in cuboid diamonds from V. Grib kimberlite pipe (Arkhangelsk province, NW Russia) reveal two contrasting types: carbonatitic and hydrous-silicic. Significant variations in phase relations and in the ratios between different phases in the microinclusions of different diamonds are consistent with the potentially wider compositional variations expected for local volumes of diamond-forming fluids/melts. Compared to the host kimberlites, diamond microinclusions show a strong enrichment in K, a shallower REE profile, and pronounced depletion in Ti, Zr and Y.

All microinclusions in diamonds from the V. Grib kimberlite pipe show enrichment in many incompatible elements, which supports their formation by partial melting of metasomatized mantle peridotites and eclogites. These data suggest that the diamonds have crystallized from carbonate-silicate fluids/melts that were derived from a source also common to kimberlites.
In the context of economic, political and cultural integration and globalization, languages tend to succumb to this process too, which can be proven by a constant flow of English borrowings. This is usually explained by the leading role of the USA and Britain in the economic and political fields and the cultural legacy of the Englishspeaking countries. The issue of an extensive use of the English borrowings in many different languages spurs a lot of debate in the society. Is it a fulfillment of the dream about one language that will unite us all or a threat for different national languages and cultures?
Dissolution dynamic nuclear polarization (D-DNP) experiments rely on the transfer of a sample between two high-field magnets. During this transfer, samples might experience passage through regions where the stray fields of the magnets are very weak, can approach zero, and even change their sign. This can lead to unexpected spectral features in spin systems that undergo transitions from weak- to strong-coupling regimes and vice versa, much like in field cycling nuclear magnetic resonance experiments. We herein demonstrate that the spectral features observed in D-DNP experiments can be rationalized, provided the time-dependence of the spin Hamiltonian upon field cycling is sufficiently adiabatic. Under such conditions, a passage through a weak static field can lead to the emergence of a long-lived state (LLS) based on an imbalance between the populations of singlet and triplet states in pairs of nuclei that are strongly coupled during the passage through low field. The LLS entails the appearance of anti-phase multiplet components upon transfer to a high-field magnet for observation of NMR signals.
Peat is a polar, highly porous material that could have significant applications as an adsorbent for removal of heavy metals from aqueous solutions. Various functional groups in lignin allow such compounds to bind on active sites of peat. The adsorption of Cu (II) from aqueous solutions on peat from the West Siberia was studied in the concentration range of 10–150 mg/L and time variations of 0.25-12 hours. The pH of the solutions varied over a range of 3.2–4.3. The adsorption data could be fitted to a Freundlich adsorption isotherm and the maximum adsorption capacity of peat was determined to be 2.5⋅10 -3 mmol / g when the initial concentration for Cu 2+ was at its minimum (0.05 mmol / L), and the time of adsorption was 30 minutes.
We perform a series of URANS simulations of the flow over a rotary oscillating cylinder at Re = 1.4 × 105 to study the possible reduction of the drag and lift forces acting on the body when the rigid wall is rotary oscillating around the axis of symmetry. Two parameters of the external forcing are varied, i.e. the amplitude of rotation and the frequency. We find that the high-frequency and relatively high-amplitude forcing leads to the drag reduction of 78% compared to the non-rotating case. The oscillations (rms) of drag and lift coefficients are also significantly reduced.
The LHCb detector is a forward spectrometer at the Large Hadron Collider (LHC) at CERN. The experiment is designed for precision measurements of CP violation and rare decays of beauty and charm hadrons. In this paper the performance of the various LHCb sub-detectors and the trigger system are described, using data taken from 2010 to 2012. It is shown that the design criteria of the experiment have been met. The excellent performance of the detector has allowed the LHCb collaboration to publish a wide range of physics results, demonstrating LHCb's unique role, both as a heavy flavour experiment and as a general purpose detector in the forward region.
Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
The hyperfine spectral structure of radiation−laser modes of the Novosibirsk terahertz free electron laser (NovoFEL) has been measured in two its main operating regimes: resonance unstable regime with maximum output power and stabilized regime with maximum spectral power.

The monochromaticity of the mode structure is shown to be practically independent of the laser operating regime and reaches a value of 2·10−8. The mode composition weakly depends on the operating regime for a well aligned electron beam and consists of many longitudinal TEMq00modes (supermode).

In the case of a poorly aligned electron beam, transverse modes of the optical cavity are also excited; its intensities strongly increase in the resonance regime.
The purpose of the article is to determine the origin of the color term kөk / kӧk in the Kazakh and Altaic languages, to trace the development of these tokens in Turkic languages and cultures, and to identify their specific usage.

The research was conducted on the basis of the dictionaries of the Kazakh and Altaic languages as well as the samples from Kazakh and Altaic prose. A historical comparative and descriptive methods have been used.

The study highlighted the main meanings of the color designations kөk ~ kök in the Kazakh and Altaic languages: blue, green and grey. They are equally common in the Kazakh and Altaic languages. Based on the meaning ‘green’ developed the meaning ‘unripe’. As for the meaning ‘gray-haired’, in the Altaic language it is used to indicate the color of the hair, while in the Kazakh language – only a beard and mustaches. In general, this meaning is manifested in contexts related to age: in the Altaic language it is old age, in Kazakh – mature age. Further the article describes synonyms of color designation kөk ~ kök. It has been shown that the color synonyms kөgіldіr, zеngіr (‘blue’) are used only in the Kazakh language, in Altaic kӧk means both blue colors. In the Kazakh language comparison of the color with such natural objects as the sky, ice, and salt was found to be more developed, for example: aspan (dai) kөk (lit.: like blue sky). The paper presents an interesting function of color designation kөk / kӧk which is intensification. It is observed in both languages; with the help of these tokens negative characteristics of the object are enhanced, for example: kaz. kөk zhalkau (lit.: blue lazy – bones), alt. kӧk tenek (lit.: complete fool). More significant differences are manifested in phraseological units, i. e. by further development of semantics in the languages. In the Kazakh language, the lexeme kөk functions as a component in phraseological units, denoting thinness and emaciation of a person, for example: kөk jambas (lit.: blue thigh) 1) very thin; 2) weak from old age, a feeble old man. In the Altaic language, such use of the lexeme kөk has not been noted. In general, we can speak of rich idiomaticity of the color scheme kөk in the Kazakh language in contrast to the Altaic language. There are also differences in the figurative use of these tokens in the structure of phraseological units: in Kazakh, these, as a rule, denote negative values, negative emotions, or associations with height, a cherished dream; in Altaic – they are used as the intensifiers ‘quite, completely”: kӧk ӱlӱsh (completely wet; lit.: blue wet). Comparing the two languages, we came to the conclusion that their greatest specificity is observed in phraseological units, which confirms the ability of phraseological units and fixed word combinations to reflect an ethnic world view and to be true keepers of the culture of the people.
Wilson's disease is an inherited disorder associated with copper accumulation in the liver, brain and other vital organs. Wilson's disease is caused by mutations in the ATP7B gene. Over 300 mutations of ATP7B have been described. Despite the disease is autosomal recessive, the patient whose PBMCs were reprogrammed in the study harbours heterozygous mutation c.3207C > A (p.H1069Q). Detailed analysis of the ATP7B complete gene sequencing data has not revealed other known disease associated mutation. The generated iPSC lines maintained the original genotype, expressed pluripotency markers, had normal karyotype and demonstrated the ability to differentiate into derivatives of the three germ layers.
Nowadays researchers provide more and more evidence that it is necessary to develop an ecologically friendly approach to pest control. This is reflected in a sharp increase in the value of the biological insecticide market in recent decades. In our study, we found a virus strain belonging to the genus Cypovirus (Reoviridae); the strain was isolated from Dendrolimus sibiricus: that possesses attractive features as a candidate for mass production of biological agents for lepidopteran-pest control. We describe morphological, molecular, and ecological features of the new Cypovirus strain. This strain was found to be highly virulent to D. sibiricus (half-lethal dose is 68 occlusion bodies per second-instar larva) and to have a relatively wide host range (infects representatives of five families of Lepidoptera: Erebidae, Sphingidae, Pieridae, Noctuidae, and Lasiocampidae). The virus strain showed a strong interaction with a nontoxic adjuvant (optical brightener), which decreased the lethal dose for both main and alternative hosts, decreased lethal time, and may expand the host range. Moreover, we demonstrated that the insecticidal features were preserved after passaging through the most economically suitable host. By providing strong arguments for possible usefulness of this strain in pest control, we call on virologists, pest control specialists and molecular biologists to give more attention to the Cypovirus genus, which may lead to new insights in the field of pest control research and may provide significant advantages to compare with baculoviruses and Bacillus thuringiensis products which are nowadays main source of bioinsecticides. Significance statement Within this article we are describing unique set of features of newly discovered cypovirus strain which possess by significant premises for modern biological insecticides requirements: high potency, universality, true regulating effect, flexible production (possibility to choose host species for production), interaction with enhancing adjuvants, ecologically friendly. Basing on genome alignment we suggest that increasing of host range of new strain is the sequence of evolutionary event which was occurred after coinfection of different CPV species within same host. This finding open new perspective to consider CPVs as perspective agent of biocontrol products.