Hengzongshu/ArticleAgent huggingface dataset:
Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood. However, global epigenetic signatures following early life stress in these models remain unclear. In this study, we carried out a ChIP-seq analysis of H3K4 trimethylation profile in the prefrontal cortex of adult male mice with a history of early life stress. Two types of stress were used: prolonged separation of pups from their mothers (for 3 h once a day, maternal separation, MS) and brief separation (for 15 min once a day, handling, HD). Adult offspring in the MS group demonstrated reduced locomotor activity in the open field test accompanied by reduced exploratory activity, while the HD group showed decreased anxiety-like behavior only. In a group of maternal separation, we have found a small number (45) of slightly up-regulated peaks, corresponding to promoters of 70 genes, while no changes were observed in a group of handling. Among the genes whose promoters have differential enrichment of H3K4me3, the most relevant ones participate in gene expression regulation, modulation of chromatin structure and mRNA processing. For two genes, Ddias and Pip4k2a, increased H3K4me3 levels were associated with the increased mRNA expression in MS group. The distribution of H3K4me3 in prefrontal cortex showed relatively low variability across all individuals, and only some subtle changes were revealed in mice with a history of early life stress. It is possible that the observed long-lasting behavioral alterations induced by maternal separation are mediated by other epigenetic mechanisms, or other brain structures are responsible for these effects.
Bennett Island stands alone in a remote part of the Arctic and information on its geology is essential to ascertain relations with other terranes in order to restore the early Palaeozoic Arctic palaeogeography.

Lower Palaeozoic sedimentary rocks throughout the island were studied thoroughly for the first time. The Ordovician section (> 1.1 km thick) comprises three units: Tremadocian, lowest Floian black shale (130–140 m); Floian, lower Dapingian carbonate turbidite (> 250 m); and Dapingian, lower Darriwilian siliciclastic turbidite (> 730 m). Ordovician deposits conformably overlie Cambrian rocks deposited within the Siberian shelf, as shown earlier. Most of the Ordovician succession was formed in a deep trough that received carbonate debris from a nearby carbonate platform and silicate material from a distant landmass located to the NE (present coordinates).

The Bennett Island Ordovician rocks have much in common with those of both the Central and Northern Taimyr belts. It could be tentatively suggested that both belts merged at their eastern continuation in the vicinity of De Long Islands. The whole system probably extends further eastwards. The Ordovician facies patterns and faunal assemblages in the New Siberian Islands are notably similar to those of northwestern Alaska, where the same lateral transition from turbidites to shelf limestones was reported.
The contribution summarizes the results of recent studies of phase transitions induced by high pressure in a number of molecular organic crystals, such as polymorphs of paracetamol, chlorpropamide, polymorphs of glycine, L- and DL-serine, β-alanine. The main attention is paid to the following topics: (1) Reversible / irreversible transformations; (2) Different behavior of single crystals / powders; (3) The role of pressure-transmitting liquid; (4) The role of the kinetic factors: phase transitions on decompression, or after a long storage at a selected pressure; (5) Isosymmetric phase transitions; (6) The role of the changes in the hydrogen bond networks / intramolecular conformational changes in the phase transitions; (7) Superstructures / nanostructures formed as a result of pressure-induced phase transitions.
By angle-resolved photoemission spectroscopy (ARPES) we observe a giant Rashba-type spin splitting in the electronic bulk conduction and valence bands of the semiconductor BiTeCl. This material belongs to the group of bismuth tellurohalides BiTeX (X = Cl,Br,I) which are layered non-centrosymmetric materials with strong spin–orbit interaction. By photon energy-dependent ARPES, we separate the bulk and surface contribution of the electronic structure and show that the tellurium-terminated (0001) crystal surface hosts spin-split two-dimensional surface states. On the chlorine-terminated surface at the opposite side of the crystal no surface states are observed due to photon-induced surface chemistry.
The antagonism of Agouti protein (AP) and Agouti-related protein on melanocortin receptors suggests an inhibitory role in the regulation of steroidogenesis. However, we have previously demonstrated that ectopic AP overexpression increased restraint-induced corticosterone release and adrenal reactivity to ACTH in mice. A high steroidogenic response to ACTH may be a consequence of a stimulatory AP action on the adenylate cyclase (AC) and/or intracellular steroidogenic enzymes.

The aim of the present study was to estimate the effect of ectopic AP overexpression on the activity of AC and steroidogenic intracellular enzymes.ACTH and forskolin were used for AC stimulation, and dibutyryl cAMP and progesterone were used for stimulation of intracellular steroidogenic enzymes in isolated adrenal cells in male C57Bl/6J mice of two Agouti genotypes: A(y)/a (ectopic AP overexpression) and a/a (absence of AP in all tissues).

ACTH and forskolin increased cAMP accumulation to the same extent in both A(y)/a and a/a mouse adrenal cells (P<0.001; ANOVA), but resulted in higher corticosterone production in A(y)/a mice (P<0.001 for ACTH and P<0.01 for forskolin; ANOVA). Dibutyryl cAMP- and progesterone-induced corticosterone production was higher in A(y)/a mice than in a/a mice (P<0.001 for dibutyryl cAMP and P<0.01 for progesterone; ANOVA).Ectopic AP overexpression increased stimulated corticosterone production and intracellular steroidogenic enzyme reactivity to cAMP without an effect on AC activity.
A new logic of reducing the two-time formalism to a highly informative scenario of redistribution of plasma particles in momentum due to Coulomb collisions is reported. Based on objective plasma evolution equations following from a properly reduced full plasma description, it has a more sound foundation than that presented in the previous report on increasing the informativeness of scenarios of the phenomenon. The possibilities of adapting the approach to the further development of more informative scenarios of plasma collisional relaxation and the modelling of transport phenomena are discussed.
Objective: to establish associations of cognitive functions (CFs) and professional level in an open population of Novosibirsk aged 25–44 years.

Patients and methods. The subject of the study was a random representative sample of one of the Novosibirsk districts population aged 25–44 years (463 men, mean age 35.94±5.957 years, and 546 women, mean age 36.17±5.997 years) in 2013–2016. CFs were screened using: A.R. Luria 10 words learning task – immediate and delayed recall after the interfering task; Bourdon Test (BT); exclusion of 'the fifth extra' test; verbal fluency test (naming animals in 1 min). Education level and professional status were assessed according to the criteria of the WHO international program MONICA protocol.

Conclusion. A quantitative association has been established between a low professional level, level of education and a decrease in cognitive functions among people aged 25–44 years.
1, 2 1 Новосибирский государственный университет, Новосибирск, Россия 2 Институт автоматики и электрометрии СО РАН, Новосибирск, Россия ВЛИЯНИЕ СКОРОСТИ СКАНИРОВАНИЯ НА ФОРМИРОВАНИЕ ТЛИПСС РАДИАЛЬНО-СИММЕТРИЧНЫМ И ЭЛЛИПТИЧЕСКИМ ГАУССОВЫМ ФЕМТОСЕКУНДНЫМ ЛАЗЕРНЫМ ПУЧКОМ Представлены результаты по исследованию формирования ТЛИППС при воздействии радиально-симметричного и астигматического гауссова пучка и различной скорости сканирования.Обнаружена линейная зависимость максимальной скорости сканирования от диаметра пучка при фиксированной частоте повторения импульсов в случае радиально-симметричного гауссова пучка.При воздействии астигматического гауссового пучка при сканировании с различной скоростью вдоль поверхности образца, как и в
Experimental and numerical investigations of a supersonic flow around a cylindrical model with a porous frontal insert made of a high-porosity cellular material performed at the Khristianovich Institute of Theoretical and Applied Mechanics of the Siberian Branch of the Russian Academy of Sciences are briefly reviewed.

New data on the influence of the angle of attack on the flow around a cylinder with a porous frontal insert are reported.

Methods of using high-porosity cellular materials for controlling supersonic flows around axisymmetric bodies are demonstrated.
Conjugated heat and mass transfer during nonisothermal absorption on a liquid film, flowing over nonuniformly cooled wall under the action of gas flow

is numerically investigated in this paper. The intensity of the tangential stress and that of the wall cooling were varied

The absorption efficiency was determined by the conjugation of two factors: the intensity of heat removal and the action of shear stress
The generation of terahertz electromagnetic radiation due to the coalescence of upper-hybrid waves in the long-wavelength region of strong plasma turbulence driven by a high-current relativistic electron beam in a magnetized plasma is investigated. The width of the frequency spectrum and the angular characteristics of this radiation for various values of plasma density and turbulence energy are calculated using the simple theoretical model adequately describing beam–plasma experiments at mirror traps. It is shown that the power density of electromagnetic emission at the second harmonic of plasma frequency in the terahertz range for these laboratory experiments can reach the level of 1 MW cm−3 with 1% conversion efficiency of beam energy losses to electromagnetic emission.
Using the density functional theory with the hybrid functional B3LYP and the basis of localized orbitals of the CRYSTAL17 program code, the dependences of the wavenumbers of normal long-wave ν vibrations on the P(GPa) pressure ν(cm−1) = ν0 + (dv/dP)·P + (d2v/dP2)·P and structural parameters R(Å) (R: a, b, c, RM-O, RC-O): ν(cm−1) = ν0 + (dv/dR) − (R − R0) were calculated.

Calculations were made for crystals with the structure of calcite (MgCO3, ZnCO3, CdCO3), dolomite (CaMg(CO3)2, CdMg(CO3)2, CaZn(CO3)2) and aragonite (SrCO3, BaCO3, PbCO3).

A comparison with the experimental data showed that the derivatives can be used to determine the P pressures, a, b, c lattice constants and the RM-O metal-oxygen, and the RC-O carbon-oxygen interatomic distances from the known Δν shifts. It was found that, with the increasing pressure, the lattice constants and distances R decrease, and the wavenumbers increase with velocities the more, the higher the ν0 is. The exceptions were individual low-frequency lattice modes and out-of-plane vibrations of the v2-type carbonate ion, for which the dependences are either nonlinear or have negative dv/dP (positive dv/dR) derivatives. The reason for this lies in the properties of chemical bonding and the nature of atomic displacements during these vibrations, which cause a decrease in RM-O and an increase in RC-O.
The notion of the Jacobian group of graph (also known as Picard group, sandpile group, critical group) was independently given by many authors.This is a very important algebraic invariant of a finite graph.In particular, the order of the Jacobian group coincides with the number of spanning trees for a graph.The latter number is known for the simplest families of graphs such as Wheel, Fan, Prism, Ladder and Möbius ladder graphs.At the same time the structure of the Jacobian group is known only in several cases.The aim of this paper is to determine the structure of the Jacobian group of the Möbius ladder and Prism graphs.
We report the first measurement of the lepton forward-backward asymmetry AFB as a function of the squared four-momentum of the dilepton system, q2, for the electroweak penguin process B→Xsℓ+ℓ− with a sum of exclusive final states, where ℓ is an electron or a muon and Xs is a hadronic recoil system with an s quark. The results are based on a data sample containing 772×106 B¯B pairs recorded at the Υ(4S) resonance with the Belle detector at the KEKB e+e− collider. AFB for the inclusive B→Xsℓ+ℓ− is extrapolated from the sum of 10 exclusive Xs states whose invariant mass is less than 2 GeV/c2. For q2>10.2 GeV2/c2, AFB<0 is excluded at the 2.3σ level, where σ is the standard deviation. For q2<4.3 GeV2/c2, the result is within 1.8σ of the standard model theoretical expectation.Received 28 February 2014Corrected 9 March 2016DOI:https://doi.org/10.1103/PhysRevD.93.032008© 2016 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasParticle decaysPhysical SystemsBottom mesonsPropertiesCP symmetryFlavor symmetriesTechniquesLepton collidersParticles & Fields
In this paper, we study the singular pure braid group [Formula: see text] for [Formula: see text]. We find generators, defining relations and the algebraical structure of these groups. In particular, we prove that [Formula: see text] is a semi-direct product [Formula: see text], where [Formula: see text] is an HNN-extension with base group [Formula: see text] and cyclic associated subgroups. We prove that the center [Formula: see text] of [Formula: see text] is a direct factor in [Formula: see text].
Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised.

They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having an IC50 value of 0.64 µM. When tested in the A-549 lung adenocarcinoma cell line, no or very limited cytotoxic effect was observed for the ligands. However, in conjunction with topotecan, a well-established Topoisomerase 1 (Top1) poison in clinical use against cancer, derivative 46a was very cytotoxic at 5 µM concentration, displaying strong synergism. This effect was only seen for 46a (IC50—3.3 µM) albeit some other ligands had better IC50 values. Molecular modelling into the catalytic site of Tdp1 predicted plausible binding mode of 46a, effectively blocking access to the catalytic site.

However, in conjunction with topotecan, a well-established Topoisomerase 1 (Top1) poison in clinical use against cancer, derivative 46a was very cytotoxic at 5 µM concentration, displaying strong synergism. This effect was only seen for 46a (IC50—3.3 µM) albeit some other ligands had better IC50 values.
Thermocapillary breakdown of thin (0.3–0.7 mm) horizontal layers of liquid (ethanol) when heated from a localized hot spot was investigated experimentally. The effects of layer thickness and the surface properties of the substrates on the breakdown dynamics were studied. Visualization and control of the liquid layer were carried out using schlieren and shadowgraphy techniques. Main steps of the breakdown process were determined and average velocity of the dry spot formation was measured. Significant influence of the substrate properties on breakdown dynamics has been found. It was shown that one of the main factors affecting the dynamics of layer breakdown and the formation of dry spots in the heating area besides the thermocapillary effect is evaporation.
The basin has been intensively glaciated as evidenced by the till covering the gentler slopes, several morainic complexes, kame terraces and roches moutonnées.

As part of an archaeological research project, we investigate the geomorphology of the cold and arid study area by combining field mapping with use of orthoimages and DEM.

The present morphodynamics of this permafrost-affected basin is mainly periglacial, with blockfields, solifluction lobes, patterned ground and rock glaciers on gentle slopes to high-elevated flat terrain, and block slopes and rockfall talus on steeper slopes. Large alluvial fans at the outlet of the steep lateral valleys constrain the anastomosing channel of the Kalguty river. Active braided channels in those valleys evidence seasonal high peak discharge.
We report how only one electron transfer from the hydrophilic reduced cluster [{Re6Se8}(CN)6]4- induces both a dramatic increase of the host-guest affinity with γ-cyclodextrin and a drastic alteration of the supramolecular dynamics.

This striking behaviour, underlined by its thermochemical fingerprint,

indicates that the self-assembly process is driven by a chaotropic effect.
Varicose veins of the lower limbs are one of the most common and wide-spread pathology all around the world. What triggers the specific changes in a vein wall still remains unclear as well as what happens in the layers of the vein wall after the disease starts. The aim of the article is to analyze published data and results of researches on epidemiology, genetics, cellular and molecular mechanisms underlying varicose veins pathogenesis. It is now commonly accepted that vein wall changes in patients with varicose veins result from vein-specific inflammation. This process includes leukocytes adhesion to venous endothelium with their subsequent migration into the vein wall and surrounding tissues. Activated leukocytes express a number of molecules that lead to vein wall remodeling and dilation. Comprehensive assessment of the epidemiological data on the prevalence of varicose veins and risk factors, of the findings from genetic studies, of data on molecular-cell interactions as well as results of various surgical interventions in patients with varicose veins, shows that remodeling is a reversible process that can be stopped and reversed by different stimuli including some chemical substances. For the first time in the literature, the authors assume that varicose veins can be successfully cured pharmacologically with no surgical interventions needed.
As in earlier works, Papers I–III, pronounced effects of intramolecular scalar spin-spin interactions, J-couplings, on spin relaxation were found.

Nuclear Magnetic Relaxation Dispersion (NMRD) of protons was studied in the pentapeptide Met-enkephalin and the amino acids, which constitute it. Experiments were run by using high-resolution Nuclear Magnetic Resonance (NMR) in combination with fast field-cycling, thus enabling measuring NMRD curves for all individual protons.

The experimental data are in good agreement with theory. From modelling the relaxation experiments we were able to determine motional correlation times of different residues in Met-enkephalin with atomic resolution. This allows us to draw conclusions about preferential conformation of the pentapeptide in solution, which is also in agreement with data from two-dimensional NMR experiments (rotating frame Overhauser effect spectroscopy). Altogether, our study demonstrates that high-resolution NMR studies of magnetic field-dependent relaxation allow one to probe molecular mobility in biomolecules with atomic resolution.
Anderson localization

We experimentally demonstrate Anderson localization for optical pulses in time domain, using a photonic mesh lattice implemented with coupled optical fiber loops

We also discuss interplay of photonic band-gaps and disorder in such lattices
This study showed that silicon dioxide of plant origin penetrated into the human body unchanged and was transferred through the blood to the heart

where absorbed by the pathological hydroxyapatite of mineralized heart valves
The aim of the study was to explore the ecological diversity of wild birds in Siberia, which are the natural reservoir of avian influenza virus (AIV). Cloacal swabs and intestinal fragments were collected from wild migratory birds from 2007‒2014. Isolated viruses were grown in the allantoic cavity of embryonated chicken eggs. The presence of virus was determined using hemagglutination assays. Primary identification and subtyping of influenza viruses was confirmed by RT-PCR. A total of 2300 samples obtained from wild migratory birds of 8 orders were collected and tested. Influenza was detected in 185 birds of 3 orders. Species of family Anatidae (order Anseriformes) such as European Teal (Anas crecca), Garganey Teal (A. querquedula), and Shoveler (A. clypeata) play the main role in AIV circulation in the south of Western Siberia. The proportion of viral carriers among waterfowl ranged from 5.6 to 20% in 2007‒2014. The order Charadriiformes had lower virus isolation rates of not more than 1.4%. Wild migratory waterfowl of orders Anseriformes and Charadriiformes are the main reservoir of AIV in the south of Western Siberia. This area plays a key role in persistence, evolution, and geographical distribution of avian influenza.
We build an ℵ 1 -categorical but not ℵ 0 -categorical theory whose only computably presentable model is the saturated one.As a tool, we introduce a notion related to limitwise monotonic functions.
We calculate electron and nuclear spin relaxation rates in a quantum dot due to the combined action of Nyquist noise and electron-nuclei hyperfine or spin-orbit interactions.

The relaxation rate is linear in the resistance of the gate circuit and, in the case of spin-orbit interaction, it depends essentially on the orientations of both the static magnetic field and the fluctuating electric field, as well as on the ratio between Rashba and Dresselhaus interaction constants.

We provide numerical estimates of the relaxation rate for typical system parameters, compare our results with other, previously discussed mechanisms, and show that the Nyquist mechanism can have an appreciable effect for experimentally relevant systems.
The $e^+e^- \rightarrow K_S K_L \pi^0$ cross section is measured in the center-of-mass energy range $\sqrt{s}=1.3-2.0$ GeV. The analysis is based on the data sample with an integrated luminosity of 33.5 pb$^{-1}$ collected with the SND detector at the VEPP-2000 $e^+e^-$ collider.
The aim of this article is to study the variation of topical structure depending on the intentions of the speaker.

The article proposes a method of comparative study of voiced texts via their topical structure, which allows observing paradigmatic potential of a sentence within a preset context. In order to do so, the thematic-rhematic articulation of the text is compared to the articulations of its audio recordings. The deviations observed serve as a representation of the communicative intentions of the speaker.

In the short story under consideration, more than a half of the utterances exhibit at least some degree of variation. The examples show that the thematic-rhematic articulation of an utterance influences its meaning, the way it interacts with the context and in some cases even its syntactic structure. Thus, thematic-rhematic articulation is a key concept for describing realization of a sentence in speech.