Hengzongshu/ArticleAgent huggingface dataset:
Physically meaningful simulations in plasma physics and astrophysics need powerful hybrid supercomputers equipped with computation accelerators.

The development of parallel numerical codes for such supercomputers is a complex scientific problem. In order to solve it the concept of co-design is employed. The co-design is defined as considering the architecture of the supercomputer at all stages of the development of the code. The use of co-design is shown by the example of two physical problems: the interaction of an electron beam with plasma and the collision of galaxies.

The resulting speedup and efficiency are shown.
We study the flow over a cylinder placed between two parallel rigid walls using Large - eddy simulations. The Reynolds number based on the inflow velocity and diameter of the cylinder is 3750 corresponding to the subcritical regime with laminar separation.The comparison of the time - averaged flow patterns shows very good agreement with experiments.The unsteadiness of the recirculating bubble features the low - frequency modulation observed for the first time.
As a gendered perspective has emerged in wider society over the past 50 or so years, a greater interest in gender- and age-related research in science has similarly occurred, including for the study of the past (archaeology) and the present (ethnology).

Here, I focus on the Mal'ta collection - a well-known Ice Age site located in Siberia. In particular, I focus on several mammoth ivory anthropomorphic sculptures which appear to reflect stages of human childhood, including infancy and the teenage years. These sculptures feature realistic elements, including proportions of each phase of childhood consistent with anthropometric data, details of clothing and accessories, and special benchmarks of puberty. Additionally, I discuss the burial of two children also found at Mal'ta, which provides additional insights into childhood within this Ice Age society.

Based on these figurines, I propose a developmental framework of the Paleolithic child from this society. Particular attention is given to artefacts such as the 'hanging birds' and animal figurines with a flat base for standing. These artefacts could be interpreted as toys, as amulets for a child's cradle or as family heirlooms, with analogies to such objects preserved in the cultures of the aboriginal population of Siberia and the Far North.
Using 1.06×108 ψ(3686) events recorded in e+e− collisions at √s=3.686 GeV with the BESIII at the BEPCII collider

we present searches for C-parity violation in J/ψ→γγ and γϕ decays via ψ(3686)→J/ψπ+π−

No significant signals are observed in either channel. Upper limits on the branching fractions are set to be B(J/ψ→γγ)<2.7×10−7 and B(J/ψ→γϕ)<1.4×10−6 at the 90% confidence level. The former is one order of magnitude more stringent than the previous upper limit, and the latter represents the first limit on this decay channel.
ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with an increased risk of schizophrenia, obesity, Crohn's disease, and reduced blood Mn.

Here, we used CRISPR/Cas9-mediated knockin (KI) to generate a mouse model of ZIP8 A391T (Zip8 393T-KI mice). Recapitulating the SNP association with blood Mn, blood Mn was reduced in Zip8 393T-KI mice. There was restricted abnormal tissue Mn homeostasis, with decreases in liver and kidney Mn and a reciprocal increase in biliary Mn, providing in vivo evidence of hypomorphic Zip8 function. Upon challenge in a chemically induced colitis model, male Zip8 393T-KI mice exhibited enhanced disease susceptibility. ZIP8 391-Thr associated with reduced triantennary plasma N-glycan species in a population-based cohort to define a genotype-specific glycophenotype hypothesized to be linked to Mn-dependent glycosyltransferase activity.

This glycophenotype was maintained in a cohort of patients with Crohn's disease. These data and the pleiotropic disease associations with ZIP8 391-Thr suggest underappreciated roles of Mn homeostasis in complex human disease.
Aim. To identify the impact of gender differences in family stress on the risk profile of arterial hypertension (AH) in the general population aged 25–64 years in Russia / Siberia.

Methods. A random representative sample of the Novosibirsk population of both sexes aged 25–64 (men: n = 657, 44.3±0.4 years, response rate – 82.1%; women: n = 689, 45.4±0.4 years, response rate ‒ 72.5%) was screened in the WHO “MONICApsychosocial program” in 1994. The screening program included the collection of social and demographic data and assessment of family stress. 229 new cases of arterial hypertension in women and 46 cases in men have been determined within the 16-year follow-up.

Results. Men (31.5%) had higher level of family stress in the general population aged 25–64, than women (20.9%). In the 16-year period, the risk of hypertension was higher in men (HR = 2.24) than women (HR = 1.39) exposed to family stress. After the adjustment to the social status and age, the risk of developing hypertension remained higher in men than in women (RR = 1.9 vs. HR = 1.37, respectively). Divorced and widowed men had the highest risk of arterial hypertension compared to women aged 45–54 years (HR = 12.7 vs. HR = 10.6 vs. HR = 2.86, respectively). Conclusion. Family stress is more common in men than in women. Risk of arterial hypertension is higher in men than in women who experienced family stress.
(1) Recently, metabolic profiling of the tissue in the native state or extracts of its metabolites has become increasingly important in the field of metabolomics. An important factor, in this case, is the presence of blood in a tissue sample, which can potentially lead to a change in the concentration of tissue metabolites and, as a result, distortion of experimental data and their interpretation. (2) In this paper, the metabolomic profiling based on NMR spectroscopy was performed to determine the effect of blood contained in the studied samples of brain tissue on their metabolomic profile. We used 13 male laboratory CD-1® IGS mice for this study. The animals were divided into two groups. The first group of animals (n = 7) was subjected to the perfusion procedure, and the second group of animals (n = 6) was not perfused. The brain tissues of the animals were homogenized, and the metabolite fraction was extracted with a water/methanol/chloroform solution. Samples were studied by high-frequency 1H-NMR spectroscopy with subsequent statistical data analysis. The group comparison was performed with the use of the Student’s test. We identified 36 metabolites in the brain tissue with the use of NMR spectroscopy. (3) For the major set of studied metabolites, no significant differences were found in the brain tissue metabolite concentrations in the native state and after the blood removal procedure. (4) Thus, it was shown that the presence of blood does not have a significant effect on the metabolomic profile of the brain in animals without pathologies.
Эстетический феномен японской татуировки ирэдзуми и ее связь с искусством гравюры укиё-э

на примере графики Утагава Куниёси

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The memorial Belyaev conference-2017 continued traditions of BGRS\SB and PlantGen conference series comprising several science sections including Plant Biology.Over the last two decades, since 1998, the BGRS/SB series gained a reputation as a prime meeting venue in Russia for biologists, computer scientists, mathematicians and biochemists working in the interdisciplinary systems biology field, now focusing more on computational plant biology.

The section on Plant Biology at Belyaev Conference-2017 was dedicated to genomic and post-genomic approaches to analysis of the organization of the plant genomes, the development of sequencing and genotyping applications for plants, with special emphasis to important crop cultivars.

Plant-Gen-2017 event in Almaty, Kazakhstan (http://pri
We have searched for the decay ${B}^{0}\ensuremath{\rightarrow}\ensuremath{\phi}\ensuremath{\gamma}$ using the full Belle data set of $772\ifmmode\times\else\texttimes\fi{}{10}^{6}$ $B\overline{B}$ pairs collected at the $\mathrm{\ensuremath{\Upsilon}}(4\text{S})$ resonance with the Belle detector at the KEKB ${e}^{+}{e}^{\ensuremath{-}}$ collider.

No signal is observed, and we set an upper limit on the branching fraction of $\mathcal{B}({B}^{0}\ensuremath{\rightarrow}\ensuremath{\phi}\ensuremath{\gamma})<1.0\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ at the 90% confidence level.

This is the most stringent limit on this decay mode to date.
Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out-both in humans and in animal models-confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum. Pathogenic microflora of the oral cavity, through mechanisms of immunomodulation, can affect the motility of the gallbladder and the expression of mucin genes (
This work is devoted to the phenomenon of levitation of liquid microdroplets above hot liquid interfaces. The droplets levitate due to air-vapour upward flow from the liquid surface and grow in time due to condensation. It was found that the diameter of droplets linearly increases with time. The maximum possible and minimum possible droplet sizes were measured depending on the substrate temperature.
Clinical and experimental findings have implicated brain α2-adrenoceptors in the regulation of many physiological functions, including sexual activity and stress-related behavior. However, which subtypes of the three α2-adrenoceptors that have now been cloned (α2A, α2B, and α2C) are involved in these controls have yet to be established.

Here, we investigated the contribution of α2A-adrenoceptors of the locus ceruleus, the principal source of brain noradrenaline, to exploratory and sexual behaviors. Using administration of antisense oligodeoxynucleotide to inhibit the receptor expression, we found that reductions in brainstem α2A-adrenoceptor mRNA levels and α2-adrenoceptor densities induced by antisense treatment were not accompanied by any changes in the major characteristics of male sexual activity, such as mount latencies and numbers of mounts.

However, in sexual behavior tests, antisense-treated male rats had decreased numbers of rearings and thus have higher percentages of behaviors positively correlated with sexual activity. Besides, antisense-treated animals had decreased anxiety in plus-maze tests. The data demonstrate that inhibition of α2A-adrenoceptor expression in the region of the locus ceruleus has an anxiolytic-like effect and facilitates male's attention to female in sexual behavior test.
By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H)˙, formed in the reaction of guanosine-5'-monophosphate with a triplet-excited 3,3',4,4'-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G˙+)'.
Improvement of high-tech methods of cardiac imaging and new generation sequencing with their introduction into widespread practice has significantly expanded the potential of diagnosis of rare cardiomyopathies. Modern imaging methods make it easy to reveal the myocardial non-compaction. However, in clinical practice, significant difficulties remain in the differentiation of normal/borderline patterns of increased ventricular trabecularity, morphology of myocardial noncompaction and non-compaction cardiomyopathy (NCM). After three decades of research, verifying the NCM is still a major clinical challenge. A key aspect of this problem is the lack of generally accepted recommendations on the diagnostic criteria for NCM and low number of long-term multicenter studies with segregation analysis on familial NCMs.

A promising solution is the development of a multistep algorithm for the diagnosis of NCM with the integration of familial, morphological, genetic and clinical data. The article presents a brief literary review on NCM diagnosis with a discussion of own research and comparative characteristics of clinical and genetic data.

To confirm the clinical and molecular heterogeneity of NCM, there are brief clinical observations of mixed phenotypes with a detailed presentation of overlap NCMs in the MOGE(S) classification.
We consider the triple Higgs coupling for h(125) Higgs boson within the most general 2HDM. At moderate values of parameters of model, allowing by modern data, noticeable deviation of this coupling from its SM value is improbable. This deviation can be sizable only if some measurable parameters of the model are exotic.
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats.

Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes.

These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.
The values z of many observable quantities in the Nature are determined at some discrete set of times tn, separated by a small interval Δt (which may also represent a coordinate, etc.). Let the z value in neighbour point tn+1 = tn + Δt be expressed by the evolution equation as as z(tn+1) ≡ z(tn + Δt) = f(z(tn)). This equation gives a discrete description of phenomenon.

Considering phenomena at t ≪ Δt this equation is transformed often into the differential equation allowing to determine z(t) leading to continuous description.

It is usually assumed that the continuous description describes correctly the main features of a phenomenon at values t ≫ Δt.
With the continuous development of artificial intelligence, the demand for sensors with simple preparation and strong concealment continues to increase. However, most of the high-sensitivity sensors have complex manufacturing methods, high costs, and single functions.

In this paper, a sensitive motion sensor based on the triboelectric interaction between a living plant and the human body was designed to detect the real-time movements of human beings and provide danger warning. A certain relationship exists between the triboelectric signal and the distance between the plant and the human body, with effective signals being detected in the range of 1.8 m. In addition, the triboelectric signal generated by each person is unique like a fingerprint, which can be used for biometrics. On the basis of the triboelectric signal, a wireless character entry warning system is designed.

This sensor can not only send out a wireless warning signal at a specific distance but also allow one to receive the warning information synchronously on a mobile phone in real time. The wireless movement sensor receives signals through a living plant, and it has the characteristics of convenient use, strong concealment, and shielding difficulty. This sensor has the potential to be widely used in person recognition, danger warning, and motion monitoring.
A method has been developed that allows X-ray structural analysis of polycrystals using a broad spectral band of synchrotron radiation in the range of 20-30 keV. This makes it possible to increase the number of photons in the primary beam by 2-3 orders of magnitude and, accordingly, reduce the exposure time of obtaining X-ray diffraction patterns to nanoseconds. The method is applied to reconstruct the X-ray diffraction pattern of silver behenate from the experimental X-ray diffraction curve obtained on polychromatic radiation of the VEPP-3 storage ring, which is an overlay of a thousand X-ray patterns at a thousand fixed wavelengths. It's reduced the exposure time of one X-ray diffraction patterns of a silver behenate polycrystal to 25 ns. The use of polychromatic synchrotron radiation (SR) opens up new possibilities for studying fast processes not only at XFELs but additionally at storage rings like the VEPP- 3/VEPP-4 type and will provide information on the kinetics of phase formation of explosion products directly after the detonation waves.
simple Jordan superalgebra (also known as superalgebra of Jordan brackets) and unital simple finite-dimensional Jordan superalgebras over algebraic closed fields with characteristic p≠2

described δ-derivations and δ-superderivations

received relationship between non-trivial δ-derivations and specialty of simple superalgebra, constructed new examples of non-trivial 1/2-derivations of Jordan superalgebras of vector type
An experimental approach for the production of catalyst-free hyperpolarised ethanol solution in water via heterogeneous hydrogenation of vinyl acetate with parahydrogen and the subsequent hydrolysis of ethyl acetate was demonstrated. For an efficient hydrogenation, liquid vinyl acetate was transferred to the gas phase by parahydrogen bubbling and almost completely converted to ethyl acetate with Rh/TiO 2 catalyst. Subsequent dissolution of ethyl acetate gas in water containing OH − ions led to the formation of catalyst- and organic solvent-free hyperpolarised ethanol and sodium acetate. These results represent the first demonstration of catalyst- and organic solvent-free hyperpolarised ethanol production achieved by heterogeneous hydrogenation of vinyl acetate vapour with parahydrogen and the subsequent ethyl acetate hydrolysis.
Though hundreds of thousands of papers are currently being published on HIV/AIDS, only tens of hundreds of them are devoted to the antibodies generated during the disease. Most of these papers discuss antibodies in HIV/AIDS as a diagnostic tool, and some articles describe neutralizing antibodies as a promising treatment.

In this paper, we used affinity chromatography and ELISA to isolate natural IgG from the blood of 26 HIV-infected patients. IgG preparations were separated into the subfractions containing different types of light chains, and catalytic activities of subfractions were analyzed.

Here, we show for the first time that the blood of HIV patients contains ~20% of bispecific κλ-IgG, presented with all IgG subclasses. Analysis of DNA-hydrolyzing and amylolytic activity show that most IgG preparations and subfractions are catalytically active. Our results expand the possible biological functions of natural IgG in HIV infection.
The Black-veined White Aporia crataegi (Lepidoptera: Pieridae) is a trans-Palearctic species causing damage to various fruit and berry crops. Here we analyzed Wolbachia infection in A. crataegi populations. Wolbachia bacteria are maternally transmitted intracellular symbionts of many arthropods, including numerous Lepidoptera. We have studied 376 samples of A. crataegi collected in 10 regions of Russia from the Far East to Kaliningrad. Wolbachia prevalence was very low; only eight Wolbachia-positive specimens of A. crataegi were detected in Yakutia, Republic of Buryatia, Sverdlovsk and Kaliningrad Provinces, and no infection was found in other localities. Two Wolbachia haplotypes, ST-19 and ST-109, from A and B supergroups respectively, were identified using the multilocus sequence typing (MLST) protocol. These haplotypes were also previously reported in different lepidopteran species. Both Wolbachia haplotypes were associated with the same mtDNA haplotype (as inferred from the cytochrome oxidase subunit I gene) of A. crataegi, and ST-19 with two mtDNA haplotypes. This incongruence of maternally inherited agents indicates independent cases of the bacteria acquisition in A. crataegi history. The above data suggest that Wolbachia can infect Aporia crataegi but cannot establish in the host populations.
We have measured the temperature (2.9 K &lt; T &lt; 50 K) and magnetic field (0 T &lt; B &lt; 9 T) dependences of longitudinal and Hall resistivities for HgCdTe/HgTe/HgCdTe system with HgTe quantum well width of 20.3 nm. The activation analysis of the experimental magnetoresistivity traces has been used as a quantitative tool to probe inter-Landau level distances. The activation energies were determined from the temperature dependence of the longitudinal resistivity in the regions of quantized Hall plateaus (for the filling factors ν of 1, 2 and 3) and the indications of the large values of the g factor ≅ 30–75 were found.
A search for the process $e^+e^- \to \eta^\prime$ has been performed with the SND detector at the VEPP-2000 $e^+e^-$ collider. The data were accumulated at the center-of-mass energy of $957.78\pm 0.06$ MeV with an integrated luminosity of about 2.9 pb$^{-1}$. For reconstruction of the $\eta^\prime$ meson five decay chains have been used: $\eta^{\prime}\to\eta\pi^+\pi^-$ followed by the $\eta$ decays to $\gamma\gamma$ and $3\pi^0 $, and $\eta^{\prime} \to \eta\pi^0\pi^0$ followed by the $\eta$ decays to $\pi^+\pi^-\pi^0$, $\gamma\gamma$, and $3\pi^0$. As a result, the upper limit has been set on the $\eta^\prime$ electronic width: $\Gamma_{\eta^{\prime}\to e^+e^-} < 0.0020$ eV at the 90\% confidence level.
Introduction. Being used in various industries, heat exchangers most often work under conditions of variable coolant flows and temperatures. At the same time, the existing theories of calculating the heat exchanger operation modes are based on the use of constant unitless parameters at any operation mode. Taking into account the effect of coolant rates on the heat transfer coefficient of the heat exchangers, the given relations are bound to specific types of heat exchangers and can only be used at constant coolant temperatures. The purpose of this study is to obtain expressions for determining the effect of coolant flow rates on the variable heat exchanger parameter. Materials and methods. The main variable operation modes for water-to-water heat exchangers used in heat supply systems are determined. Using simulation in the PTC Mathcad software, dependencies describing the change in the heat exchanger parameter for all the considered variable operation modes are defined. This made it possible to obtain a general formula for the change in the heat exchanger parameter for varying coolant flow rates. Coefficients in this formula take into consideration the effect of coolant temperatures, which cannot be known when calculating variable conditions, especially when the interconnected heat exchangers are operating. Results. To test applicability of the existing relations describing the change in the heat exchanger parameter and of obtained formula, a large number of heat exchangers is calculated at variable operation modes. Comparison with the simulation results shows that the correlations of heat exchanger theories work well at the mode with constant coolant temperatures only, while their use at other operation modes can lead to large calculation errors. Conclusions. The obtained formula allows finding the effect of coolant flow rates on the variable heat exchanger parameter. The formula can be used to predict the operation modes of large systems including a large number of various-type heat exchangers.
Conjugated heat and mass transfer during nonisothermal absorption on a liquid film, flowing over nonuniformly cooled wall under the action of gas flow, is numerically investigated in this paper. The intensity of the tangential stress and that of the wall cooling were varied. The absorption efficiency was determined by the conjugation of two factors: the intensity of heat removal and the action of shear stress.