Hengzongshu/ArticleAgent huggingface dataset:
An overview on the underlying principles of the hybrid plasma wakefield acceleration scheme dubbed "Trojan Horse" acceleration is given. The concept is based on laser-controlled release of electrons directly into a particle-beam-driven plasma blowout, paving the way for controlled, shapeable electron bunches with ultralow emittance and ultrahigh brightness. Combining the virtues of a low-ionization-threshold underdense photocathode with the GV/m-scale electric fields of a practically dephasing-free beam-driven plasma blowout, this constitutes a 4th generation electron acceleration scheme. It is applicable as a beam brightness transformer for electron bunches from LWFA and PWFA systems alike. At FACET, the proof-of-concept experiment "E-210: Trojan Horse Plasma Wakefield Acceleration" has recently been approved and is in preparation. At the same time, various LWFA facilities are currently considered to host experiments aiming at stabilizing and boosting the electron bunch output quality via a trojan horse afterburner stage. Since normalized emittance and brightness can be improved by many orders of magnitude, the scheme is an ideal candidate for light sources such as free-electron-lasers and those based on Thomson scattering and betatron radiation alike.
Russian regions are known to be economically different. While economic inequality is quite natural for a large country, it can lead to depopulation of less developed regions. Thus, the scale of this phenomenon should be assessed and taken into account in development programmes of the Eastern regions of Russia. The study aims to examine population dynamics and migration processes occurring in Asian Russia in the first decades of the 21st century, focusing on the role of human capital at different stages of regional economic development. Migration losses and gains of Asian Russia were estimated based on information on internal migration of the population by education level and the author’s approach to assessing the accumulated human capital. The calculations confirm a hypothesis that losses from the population outflow in the studied region exceed its gains from the inflow, negatively influencing the possibilities of accelerated economic growth. The conducted research presents new results concerning the outflow of human capital from Asian Russia in the period after 2008. Considering foreign experience in reducing negative effects that have also been recently observed in the region, it is proposed to intensify efforts in three major areas: new knowledge as a factor of spatial connectivity; consolidation of the population; implementation and support of economic activity in Asian Russia. The calculation results can be used in development programmes of the Eastern regions of Russia.
Double-walled carbon nanotubes (DWCNTs) are fluorinated using (1) fluorine F2 at 200 °C, (2) gaseous BrF3 at room temperature, and (3) CF4 radio-frequency plasma functionalization. These have been comparatively studied using transmission electron microscopy and infrared, Raman, X-ray photoelectron, and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. A formation of covalent C-F bonds and a considerable reduction in the intensity of radial breathing modes from the outer shells of DWCNTs are observed for all samples. Differences in the electronic state of fluorine and the C-F vibrations for three kinds of the fluorinated DWCNTs are attributed to distinct local surroundings of the attached fluorine atoms. Possible fluorine patterns realized through a certain fluorination technique are revealed from comparison of experimental NEXAFS F K-edge spectra with quantum-chemical calculations of various models. It is proposed that fluorination with F2 and BrF3 produces small fully fluorinated areas and short fluorinated chains, respectively, while the treatment with CF4 plasma results in various attached species, including single or paired fluorine atoms and -CF3 groups. The results demonstrate a possibility of different patterning of carbon surfaces through choosing the fluorination method.
This work presents, for the first time, the results of studies of stimulated Raman scattering (SRS) in 1.2-km P2O5-doped silica fiber of radiation of single- and double-scale picosecond pulses generated in a fiber master oscillator and amplified in a one-stage fiber amplifier. Shown are differences in supercontinuum spectra composed of several Stokes components when pumped with pulses of different structure. More efficient Raman transformation of double-scale pulses was identified, leading to broader supercontinuum spectra.
Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA.

Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fluorescently labeled DNA probe. Of these, using samples from 3 patients, 66% to 100% cells are also positive for CD133, a well-established surface marker of tumor-initiating glioma stem cells. Using the samples from primary malignant brain lesions (33 patients), we demonstrate that tumor grading significantly correlates ( R = .71) with the percentage of DNA-internalizing cells.

No such correlation is observed for relapse samples (18 patients).
extending thereby results by Baikov and Chetyrkin obtained at transcendentality weight seven

using a recently developed method of one of the present coauthors (R.L.) to evaluate a Laurent expansion in dimensional regularization parameter $ε=(4-d)/2$ of all the master integrals for four-loop massless propagators up to transcendentality weight twelve

We observe only multiple zeta values in our results. Therefore, we conclude that all the four-loop massless propagator integrals, with any integer powers of numerators and propagators, have only multiple zeta values in their epsilon expansions up to transcendentality weight twelve.
Data on the process of fractionation, mechanical activation and subsequent enzymatic hydrolysis of pea seeds proteins was obtained.

As a result of fractionation of plant raw materials, fractions of biopolymers with different chemical composition were obtained. The conditions of mechanical activation for the protein fraction with the enzyme preparation, the optimal substrate-enzyme complex ratio and the optimal conditions for mechanically activated enzymatic hydrolysis were determined.

It was shown that under certain optimal conditions for hydrolysis of pea biomass, the protein molecules broke down and a mixture of low molecular weight products formed.
We propose a general analytical method for estimation of the saturable absorber output energy as a function of the input energy. The method is based on a representation of the saturable absorber output energy as a series of powers of the recovery time. We also derive a simplified expression of the saturable absorber output energy that gives a good approximation for large input energies. The analytical results are verified by the numerical simulation. The results have been applied to the particular cases of an input function that include the Gaussian input pulse and the hyperbolic secant input pulse. We show that the analytical results can improve the prediction of the output energy in the fiber lasers.
The BGRS conference series on bioinformatics was initiated by Academician N.A. Kolchanov
The paper is devoted to a numerical study of the uniqueness and stability of problems of determining the parameters of dynamical systems arising in pharmacokinetics, immunology, epidemiology, sociology, etc. by incomplete measurements of certain states of the system at fixed time. Significance of parameters difficult to measure is very high in many areas, as their definition will allow physicians and doctors to make an effective treatment plan and to select the optimal set of medicines. Due to the fact that the problems under consideration are ill-posed, it is necessary to investigate the degree of ill-posedness before its numerical solution.

One of the most effective ways is to study the practical identifiability of systems of nonlinear ordinary differential equations that will allow us to establish a set of identifiable parameters for further numerical solution of inverse problems. The paper presents methods for investigating practical identifiability: the Monte Carlo method, the matrix correlation method, the confidence intervals method and the sensitivity based method. There is presented two mathematical models of the pharmacokinetics of the C-peptide and mathematical model of the spread of the COVID — 19 epidemic.

The identifiability investigation will allow us to construct a regularized unique solution of the inverse problem.
Numerical simulation of the motion of a Taylor gas bubble in a heated small-diameter tube is carried out.

Two models are used to describe the dependence of surface tension on temperature. In the first model, the surface tension decreases with temperature, and in the second, it increases, which corresponds to pure water and an aqueous surfactant solution.

It is shown that the derivative sign affects the thickness of the liquid film around the bubble.
The work is devoted to an experimental study of the heat transfer when a water drop falls on a heated horizontal surface, which is a thin constantan foil coated with a fluoropolymer film.

Using infrared thermography data, the temperature distributions on the opposite side of the foil from the drop are obtained. The graphs of the temperature distribution along the line passing through the center of the foil with the drop is plotted.

The data obtained will be used to calculate the heat flux density in the region of the dynamic contact line of the drop.
Adolescent idiopathic scoliosis (AIS) affects 2–3% of children. Numerous hypotheses on etiologic/causal factors of AIS were investigated, but all failed to identify therapeutic targets and hence failed to offer a cure. Therefore, currently there are only two options to minimize morbidity of the patients suffering AIS: bracing and spinal surgery. From the beginning of 1960th, spinal surgery, both fusion and rod placement, became the standard of management for progressive adolescent idiopathic spine deformity. However, spinal surgery is often associated with complications. These circumstances motivate AIS scientific community to continue the search for new etiologic and causal factors of AIS. While the role of the genetic factors in AIS pathogenesis was investigated intensively and universally recognized, these studies failed to nominate mutation of a particular gene or genes combination responsible for AIS development.

Sharing this new approach, we investigated scoliotic vertebral growth plates removed during vertebral fusion (anterior surgery) for AIS correction. In recent publications we showed that cells from the convex side of human scoliotic deformities undergo normal chondrogenic/osteogenic differentiation, while cells from the concave side acquire a neuronal phenotype. Based on these facts we hypothesized that altered neural crest cell migration in early embryogenesis can be the etiological factor of AIS. In particular, we suggested that neural crest cells failed to migrate through the anterior half of somites and became deposited in sclerotome, which in turn produced chondrogenic/osteogenic-insufficient vertebral growth plates. To test this hypothesis we conducted experiments on chicken embryos with arrest neural crest cell migration by inhibiting expression of Paired-box 3 (Pax3) gene, a known enhancer and promoter of neural crest cells migration and differentiation.

The results showed that chicken embryos treated with Pax3 siRNA (microinjection into the neural tube, 44 h post-fertilization) progressively developed scoliotic deformity during maturation. Therefore, this analysis suggests that although adolescent idiopathic scoliosis manifests in children around puberty, the real onset of the disease is of epigenetic nature and takes place in early embryogenesis and involves altered neural crest cells migration. If these results confirmed and further elaborated, the hypothesis may shed new light on the etiology and pathogenesis of AIS.
There are risk factors that lead the normal conduction of excitation in the heart into a chaotic one. These factors include hereditary and acquired channelopathies. Many dangerous changes in the work of the heart can be identified using the patient’s electrocardiogram. Such relatively easily detectable changes include the long QT interval syndrome (LQTS). Despite a relatively high prevalence of hereditary LQTS, to which it is necessary to add both hereditary and induced LQTS as well as the ease of detection on the ECG, the mechanism of reentry formation in this syndrome is still un­known. What should be noted is a high variability of the hereditary syndrome and the fact of the connection between the increase in the heart rate and the risk of cardiac arrest. After an electrophysiological study on individual cardiac cells from patients with the LQT syndrome, it became apparent that the search for a mechanism for the transition of the normal heart rhythm to chaotic and fibrillation cannot be limited to recording ion currents in single cells. To solve this problem, we need a model of the behavior of cardiac tissue which reflects the relationship of various factors and the risk of reentry. In order to create an experimental model of LQTS in our work, the iPSC of a pati­ent-specific line from a healthy patient was differentiated into a monolayer of cardiac cells and the parameters of the excitation propagation were studied depending on the stage of differentiation. It was shown that a stable value of the propagation velocity and the response to periodic stimulation in the range of physiological values, are reached after the 30th day of dif­ferentiation.
The origin and geodynamic settings of the Ust’-Sema Formation and the Barangol Complex are some of the most controversial issues in the Early Paleozoic history of the Altai–Sayan Fold Belt. The Ust’-Sema Formation volcanic rocks are enriched in high-Ca clinopyroxene phenocrysts and were classified as ankaramites and diopside porphyry basalts.

In this work, we first present LA-ICP-MS analyses of the clinopyroxenes, along with studies of the petrography, mineral composition, and whole-rock chemistry of the Ust’-Sema Formation and related Barangol Complex rocks. An LA-ICP-MS clinopyroxene study showed a slight depletion of light rare-earth elements (La/Yb)N = 0.1–1.0 (on average 0.4); and strong depletion of the high-field-strength elements (Zr, Hf, and Nb) and large-ion lithophile (Rb) elements. An Sr anomaly showed a positive correlation with Mg#.

Major- and trace-element composition of the clinopyroxene cores show that these clinopyroxene grains were not captured from the mantle rocks as previously assumed and that the Ust’-Sema Formation and the Barangol Complex rocks were formed from magma with island arc characteristics. The increased titanium and light rare-earth element contents in the phenocryst rims from Biyka volcano suggest an active interaction of the ankaramitic magma with rocks or melts of OIB type.
Many research groups have developed various types of tissue-engineered cardiac constructs. However, the immunological properties of such artificial tissues are not yet fully understood. Previously, we developed microfiber scaffolds carrying human iPSC-derived cardiomyocytes (hiPSC-CM). In this work, we evaluated the ability of these tissue-engineered constructs to activate the expression of CD28 and CTLA-4 proteins on T lymphocytes, which are early markers of the immune response. For this purpose, electrospun PLA microfiber scaffolds were seeded with hiPSC-CM and cultured for 2 weeks. Allogeneic mononuclear cells were then co-cultured for 48 h with three groups of samples: bare scaffolds, pure cardiomyocyte culture and tissue-engineered constructs, followed by analysis of CD28/CTLA-4 expression on T lymphocytes using flow cytometry. PLA scaffolds and concanavalin A stimulation (positive control) statistically significantly increased CD28 expression on CD4+ T cells (up to 61.3% and 66.3%) CD8+ T cells (up to 17.8% and 21.7%). CD28/CTLA-4 expression was not increased when T lymphocytes were co-cultured with cardiac tissue-engineered constructs and iPSC-CM monolayers. Thus, iPSC-CM in monolayers and on PLA microfiber scaffolds did not induce T cell activation, which suggests that such cardiac constructs would not be a cause of rejection after implantation.
The results, that obtained by the spectral method with use of integral relations for the problem of linear stability of steady-state shear plane-parallel flows of an inviscid stratified incompressible fluid in the gravity field with respect to plane perturbations in the Boussinesq approximation and without it, are specified, complemented and developed by the most powerful analytical method of the modern mathematical theory of hydrodynamic stability – the second (or direct) Lyapunov method. In both case, the new analytical method made it possible to prove that given steady-state flows of stratified fluid are absolutely unstable in theoretical sense with respect to small plane perturbations and to obtain the sufficient conditions for practical linear instability of considered flows. The illustrative analytical examples of given steady-state flows and small plane perturbations as normal waves imposed on them are constructed. Using the asymptotic method, it is proved that constructed perturbations grow in time irrespective of the fact whether the Miles-Howard and the Miles-type theorems are valid or not.
We have performed a tomographic study using a joint data set that includes local and teleseismic events, recorded by a temporary network in the western branch of the East African rift system.

From the travel time residuals, we derive a three‐dimensional model of seismic P‐wave velocity anomalies for the crust and upper mantle down to a depth of 80 km. Particular attention is paid to the verification of the inversion results by various resolution tests.

The results show that the eastern rift shoulder is characterized by relatively high seismic velocities. Lower velocities are obtained beneath the entire length of the rift valley and the Rwenzori Mountains. A prominent feature is observed north‐east of the mountain range: here we detected a vertically oriented, cylindrical low‐velocity anomaly with maximum amplitudes in the middle crust and the upper mantle lithosphere. We suggest that this anomaly indicates reservoirs of molten material related to the ongoing rifting process within this segment of the rift. Just above this anomaly, at depths between 5 and 16 km, earthquake swarms exist. The observed reduction in P‐wave velocity is used to provide constraints on the possible melt content and temperature anomaly in the uppermost mantle. The observed 3–5% P‐velocity decrease can be explained by melt fraction up to 2%–3.3% or alternatively by a temperature increase of at least 248 to 376 K and even higher‐temperature anomalies are possible if lower ambient temperatures in the reference mantle are assumed. Probably, the two effects act in combination.
Gravitational instability in classical Jeans theory, General Relativity, and modified gravity is considered.

The transition to the Newtonian gauge in the case of coordinate dependent background metric functions is studied.

The background density increase leads to a faster growth of perturbations in comparison with the standard theory. For modified gravity a new high frequency stable solution is found.
If primordial black holes (PBH) saturate the present upper limit on the dark matter density in our Solar system and if their radiation spectrum is discrete, the sensitivity of modern detectors is close to that necessary for detecting this radiation. This conclusion is not in conflict with the upper limits on the PBH evaporation rate.
We experimentally demonstrate the spatial self-cleaning of a highly multimode optical beam, in the process of second-harmonic generation in a quadratic nonlinear potassium titanyl phosphate crystal. As the beam energy grows larger, the output beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background. We demonstrate that quadratic beam cleanup is accompanied by significant self-focusing of the fundamental beam, for both positive and negative signs of the linear phase mismatch close to the phase-matching condition.
The initial beam emittance determines the maximum wakefield amplitude that can be reached as a result of beam self-modulation in the plasma. The wakefield excited by the fully self-modulated beam decreases linearly with the increase of the beam emittance. There is a value of initial emittance beyond which the self-modulation does not develop even if the instability is initiated by a strong seed perturbation. The emittance scale at which the wakefield is twice suppressed with respect to the zero-emittance case (the so called critical emittance) is determined by inability of the excited wave to confine beam particles radially and is related to beam and plasma parameters by a simple formula. The effect of beam emittance can be observed in several discussed self-modulation experiments.
In disease states, mesothelial cells are exposed to variable osmotic conditions, with high osmotic stress exerted by peritoneal dialysis (PD) fluids. They contain unphysiologically high concentrations of glucose and result in major peritoneal membrane transformation and PD function loss.

The effects of isotonic entry of urea and myo-inositol in hypertonic (380 mOsm/kg) medium on the cell volume of primary cultures of rat peritoneal mesothelial cells and rat kidney outer medullary collecting duct (OMCD) principal cells were studied. In hypertonic medium, rat peritoneal mesothelial cells activated a different mechanism of cell volume regulation in the presence of isotonic urea (100 mM) in comparison to rat kidney OMCD principal cells. In kidney OMCD cells inflow of urea into the shrunken cell results in restoration of cell volume. In the shrunken peritoneal mesothelial cells, isotonic urea inflow caused a small volume increase and activated regulatory volume decrease (RVD). Isotonic myo-inositol activated RVD in hypertonic medium in both cell types. Isotonic application of both osmolytes caused a sharp increase of intracellular calcium both in peritoneal mesothelial cells and in kidney OMCD principal cells.

In conclusion, peritoneal mesothelial cells exhibit RVD mechanisms when challenged with myo-inositol and urea under hyperosmolar isotonic switch from mannitol through involvement of calcium-dependent control. Myo-inositol effects were identical with the ones in OMCD principal cells whereas urea effects in OMCD principal cells led to no RVD induction.