Hengzongshu/ArticleAgent huggingface dataset:
There is no doubt that various nanoparticles (NPs) can enter the brain from the nasal cavity. It is assumed that NPs can penetrate from blood into the central nervous system (CNS) only by breaking the blood–brain barrier (BBB). The accumulation of NPs in CNS can provoke many neurological diseases; therefore, the understanding of its mechanisms is of both academic and practical interest. Although hitting from the surface of the lungs into the bloodstream, NPs can accumulate in various mucous membranes, including the nasal mucosa. Thus, we cannot rule out the ability of NPs to be transported from the bloodstream to the brain through the olfactory uptake.

To test this hypothesis, we used paramagnetic NPs of manganese oxide (Mn3O4-NPs), whose accumulation patterns in the mouse brain were recorded using T1-weighted magnetic resonance imaging. The effect of intranasal application of endocytosis and axonal transport inhibitors on the brain accumulation patterns of intranasally or intravenously injected Mn3O4-NPs was evaluated.

A comparative analysis of the results showed that the transport of Mn3O4-NPs from the nasal cavity to the brain is more efficient than their local permeation through BBB into CNS from the bloodstream, for example with the accumulation of Mn3O4NPs in the dentate gyrus of the hippocampus, and through the capture and transport of NPs from the blood by olfactory epithelium cells. Also, experiments with the administration of chlorpromazine, a specific inhibitor of clathrin-dependent endocytosis, and methyl-β-cyclodextrin, inhibitor of the lipid rafts involved in the capture of substances by endothelium cells, showed differences in the mechanisms of NP uptake from the nasal cavity and from the bloodstream. In this study, we show a significant contribution of axonal transport to NP accumulation patterns in the brain, both from the nasal cavity and from the vascular bed. This explains the accumulation of different sorts of submicron particles (neurotropic viruses, insoluble xenobiotics, etc.), unable to pass BBB, in the brain. The results will add to the understanding of the pathogenesis of various neurodegenerative diseases and help studying the side effects of therapeutics administered intravenously.
The dominant hypothesis about the pathogenesis of Alzheimer’s disease (AD) is the “amyloid cascade” concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is proposed as an effective strategy for the prevention and therapy of AD. Recently, we found that an antibiotic ceftriaxone (CEF), which possesses neuroprotective activity, reduced cognitive deficits and neurodegenerative changes in OXYS rats, a model of sporadic AD. The molecular mechanisms of this effect are not completely clear, we suggested that the drug might serve as the regulator of the expression of the genes involved in the metabolism of Aβ and the pathogenesis of AD. The study was aimed to determine the effects of CEF on mRNA levels of Bace1 (encoding β-secretase BACE1 involved in Aβ production), Mme, Ide, Ece1, Ace2 (encoding enzymes involved in Aβ degradation), Epo (encoding erythropoietin related to endothelial function and clearance of Aβ across the blood brain barrier) in the frontal cortex, hippocampus, striatum, hypothalamus, and amygdala of OXYS and Wistar (control strain) male rats. Starting from the age of 14 weeks, animals received CEF (100 mg/kg/day, i.p., 36 days) or saline. mRNA levels were evaluated with RT-qPCR method. Biochemical parameters of plasma were measured for control of system effects of the treatment. To better understand strain variations studied here, we compared the gene expression between untreated OXYS and Wistar rats. This comparison showed a significant decrease in mRNA levels of Ace2 in the frontal cortex and hypothalamus, and of Actb in the amygdala of untreated OXYS rats. Analysis of potential effects of CEF revealed its novel targets. In the compound-treated OXYS cohort, CEF diminished mRNA levels of Bace1 and Ace2 in the hypothalamus, and Aktb in the frontal cortex. Furthermore, CEF augmented Mme, Ide, and Epo mRNA levels in the amygdala as well as the levels of Ece1 and Aktb in the striatum. Finally, CEF also attenuated the activity of ALT and AST in plasma of OXYS rats. Those findings disclosed novel targets for CEF action that might be involved into neuroprotective mechanisms at early, pre-plaque stages of AD-like pathology development.
The outbreaks of infectious diseases caused by natural factors or bioterrorism acts are, unfortunately, quite real threats for the overall population.Planning of an efficient response to an outbreak of an infectious disease requires coordinated efforts of various services aimed to most efficiently utilize the limited resources.

This paper describes a model that optimizes utilization of resources when preparing to counter the bioterrorism threats or responding to epidemics caused by epidemiologically dangerous or socially significant pathogens.The model computes the volume of limited resources as well as the particular control activities (isolation, ring vaccination, or mass vaccination) necessary to minimize the optimization criterion, comprising the total number of infected persons, number of lethal cases, and several other characteristics.

The model is available remotely via WEB-interface at http://vector-epimod.ru.
The free-living flatworm Macrostomum lignano is a model organism for evolutionary and developmental biology studies. Recently, an unusual karyotypic diversity was revealed in this species. Specifically, worms are either 'normal' 2n = 8, or they are aneuploid with one or two additional large chromosome(s) (i.e. 2n = 9 or 2n = 10, respectively). Aneuploid worms did not show visible behavioral or morphological abnormalities and were successful in reproduction.

In this study, we generated microdissected DNA probes from chromosome 1 (further called MLI1), chromosome 2 (MLI2), and a pair of similar-sized smaller chromosomes (MLI3, MLI4). FISH using these probes revealed that MLI1 consists of contiguous regions homologous to MLI2-MLI4, suggesting that MLI1 arose due to the whole genome duplication and subsequent fusion of one full chromosome set into one large metacentric chromosome.

Therefore, one presumably full haploid genome was packed into MLI1, leading to hidden tetraploidy in the M. lignano genome. The study of Macrostomum sp. 8 - a sibling species of M. lignano - revealed that it usually has one additional pair of large chromosomes (2n = 10) showing a high homology to MLI1, thus suggesting hidden hexaploidy in its genome. Possible evolutionary scenarios for the emergence of the M. lignano and Macrostomum sp. 8 genomes are discussed.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.
Human physiology under extreme conditions of life, or environmental physiology, and systems biology are natural partners. The similarities and differences between the object and methods in systems biology, the OMICs (proteomics, transcriptomics, metabolomics) disciplines, and other related sciences have been studied.

The review examines the new approaches in modern systems biology, in terms of their use for a deeper understanding of the physiological adaptation of a healthy human in extreme environments. The latest data on environmental human physiology obtained using systems biology methods are discussed. The independent achievements of systems biology in studying the adaptation of a healthy human to physical activity, including human presence at high altitude, to the effects of hypoxia and oxidative stress have been noted.

A reasonable conclusion is drawn that the application of the methods and approaches used in systems biology to study the molecular pattern of the adaptive mechanisms that develop in the human body during space flight can provide valuable fundamental knowledge and fill the picture of human metabolic pathways.
A new phenomenon is described in this paper: the formation of macroscopic channel structures on the bottom of copper ingots which were used as the target for the synthesis of copper nanoparticles by high-power electron beam evaporation and condensation. In the synthesis experiment, the cylindrical copper ingot is melted and partially evaporated in a graphite crucible. The channel structures were originally observed after a series of nanoparticle synthesis experiments in varying conditions. In the present work, various process conditions are varied in order to recreate the structures and identify their mechanism of formation. Conditions in which the channel structures form and do not form are identified and interesting microstructures are observed near the channel structures.
One of the most important goals of experimental gas dynamics is to study formation and evolution of fluctuations generated by flow over some obstacles. Such fluctuations are mostly non-stationary.

To analyze such experimental data time-frequency techniques are required such as Hilbert-Huang transform. In this paper some results of application of this technique for data analysis are presented. Specific features, advantages and disadvantages of transform are mentioned. Time series analyzed were obtained in experiments on fluctuations measurements behind a circular cylinder in two different wind tunnels at different speeds but close Reynolds number ranges.

Amplitudes of fluctuations behind a cylinder were found to have some specific behavior in each case.
The channeling of laser pulses in waveguides filled with a rare plasma is one of promising techniques of laser wakefield acceleration. A solid-state capillary can precisely guide tightly focused pulses. Regardless of the material of the capillary, its walls behave like a plasma under the influence of a high-intensity laser pulse.

Therefore, the waveguide modes in the capillaries have a universal structure, which depends only on the shape of the cross-section. Due to the large ratio of the capillary radius to the laser wavelength, the modes in circular capillaries differ from the classical TE and TM modes.

The attenuation length for such modes is two orders of magnitude longer than that obtained from the classical formula, and the incident pulse of the proper radius can transfer up to 98% of its initial energy to the fundamental mode. However, finding eigenmodes in capillaries of arbitrary cross-section is a complex mathematical problem that remains to be solved.
D-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in proteoglycan biosynthesis. However, nothing is known about expression and activity of the protein in cancer.

In this study, we investigated GLCE expression in human breast cancer using multipex RT-PCR, QRT-PCR and Western-blot assays. In total, 21 patients without malignancy and 74 patients with breast tumor were investigated.

The obtained data showed that in 82-84% of human breast tumors there is either downregulation or loss of D-glucuronyl C5-epimerase mRNA expression and significant decrease of the protein content. In most cases (77%), GLCE expression was decreased also in the normal-appearing tissue surrounding the tumor node but the protein amount was comparable to normal breast tissue. These findings represent the first data about involvement of human D-glucuronyl C5-epimerase in malignant transformation.
The search for life beyond Earth has focused on Mars and the icy moons Europa and Enceladus, all of which are considered a safe haven for life due to evidence of current or past water. The surface of Venus, on the other hand, has extreme conditions that make it a nonhabitable environment to life as we know it. This is in contrast, however, to its cloud layer, which, while still an extreme environment, may prove to be a safe haven for some extreme forms of life similar to extremophiles on Earth. We consider the venusian clouds a habitable environment based on the presence of (1) a solvent for biochemical reactions, (2) appropriate physicochemical conditions, (3) available energy, and (4) biologically relevant elements. The diversity of extreme microbial ecosystems on Earth has allowed us to identify terrestrial chemolithoautotrophic microorganisms that may be analogs to putative venusian organisms. Here, we hypothesize and describe biological processes that may be performed by such organisms in the venusian clouds. To detect putative venusian organisms, we describe potential biosignature detection methods, which include metal-microbial interactions and optical methods. Finally, we describe currently available technology that can potentially be used for modeling and simulation experiments.
Several quantum gravity and string theory thought experiments indicate that the Heisenberg uncertainty relations get modified at the Planck scale so that a minimal length do arises. This modification may imply a modification of the canonical commutation relations and hence quantum mechanics at the Planck scale. The corresponding modification of classical mechanics is usually considered by replacing modified quantum commutators by Poisson brackets suitably modified in such a way that they retain their main properties (antisymmetry, linearity, Leibniz rule and Jacobi identity). We indicate that there exists an alternative interesting possibility. Koopman–von Neumann’s Hilbert space formulation of classical mechanics allows, as Sudarshan remarked, to consider the classical mechanics as a hidden variable quantum system. Then, the Planck scale modification of this quantum system naturally induces the corresponding modification of dynamics in the classical substrate. Interestingly, it seems this induced modification in fact destroys the classicality: classical position and momentum operators cease to be commuting and hidden variables do appear in their evolution equations.
We show that an ε-power-quasisymmetric map f : A → R n can be extended to a Cε-power-quasisymmetric map F : R n → R n if A ⊂ R n satisfies a geometric thickness condition and ε is small enough.The constant C depends on c and n only.
In this study, single walled carbon nanotubes and reduced graphene oxide covalently and non-covalently functionalised by ZnPc were added to P3HT:PCBM blend

in order to investigate the effects of these hybrid materials on P3HT:PCBM organic solar cell performance
We report results on studies of the e+e- annihilation into three-body Y(nS)pi+pi- (n=1,2,3) final states including measurements of cross sections and the full amplitude analysis. The cross sections measured at sqrt(s)=10.865 GeV and corrected for the initial state radiation are sigma(e+e-=>Y(1S)pi+pi-)=(2.27+-0.12+-0.14) pb, sigma(e+e-=>Y(2S)pi+pi-)=(4.07+-0.16+-0.45) pb, and sigma(e+e-=>Y(3S)pi+pi-)=(1.46+-0.09+-0.16) pb. Amplitude analysis of the three-body Y(nS)pi+pi- final states strongly favors I^G(J^P)=1^+(1^+) quantum-number assignments for the two bottomonium-like Zb+- states, recently observed in the Y(nS)pi+- and hb(mP)pi+- (m=1,2) decay channels. The results are obtained with a $121.4 1/fb data sample collected with the Belle detector at the KEKB asymmetric-energy e+e- collider.
The crisis in a FC-72 liquid film moving under the action of a gas flow through a smooth heater was experimentally investigated.

It is shown that with gas and liquid flow rates increases a critical heat flux is growth.
The paper discusses the method of multichannel analysis of surface waves. We propose an automated method of surface waves extraction, based on the time-frequency representation of seismograms and their subsequent spatial spectral analysis. This approach is robust for the extraction of smooth and realistic dispersion curves in automatic mode. This provides a more reliable assessment of high-velocity sections of shear waves by the method of multichannel analysis of surface waves. The article presents the results of testing of the developed approach with using noisy synthetic and real seismic data.
The creation of varieties adapted to changing environmental conditions, resistant to various pathogens, and satisfying various grain purposes is impossible without using the genetic diversity of wheat. One of the ways to expand the genetic diversity of wheat is to introduce new variants of genes from the genetic pool of congeners and wild relatives into the genotypes of existing varieties. In this study, we used 10 lines from the Arsenal collection created on the genetic basis of the spring variety ‘Rodina’ and the diploid species Aegilops speltoides in the Federal Research Center “Nemchinovka” in 1994. The lines were previously characterized for the presence of translocations and chromosomal rearrangements cytologically and using molecular markers. Technological analyses were performed on grain obtained in Western Siberia and Moscow region. The aim of this study was to establish the possibilities of expanding the phenotypic diversity for technological properties of grain and flour as a result of such hybridization of bread wheat and the diploid cereal Aegilops speltoides. The variety ‘Rodina’ forms a vitreous grain with a high gluten content in Siberia, but has low physical properties of flour and dough. Five derived lines were found to have significantly higher protein and gluten content in grain. The highest values under both growing conditions were found in lines 73/00i, 82/00i, and 84/00i. Two lines (69/00i and 76/00i) showed a high flour strength and dough elasticity, characterizing the lines as strong and valuable in quality. These lines can be used for baking bread. Line 82/00i inherited from Ae. speltoides a soft-grain endosperm, which indicates the introgression of the Ha-Sp gene, homoeoallelic to the Ha gene of bread wheat, into ‘Rodina’. Flour of this line is suitable for the manufacture of confectionery without the use of technological additives. The lines generally retained their characteristics in different growing conditions. They can be attracted as donors of new alleles of genes that determine the technological properties of grain and resistance to biotic stresses.
The paper examines the attitude to uncertainty and risk within the Russian model of management by A.P. Prokhorov. It is shown that the attitude is determined by the dual nature of this model.

The Russian management system in its mobilization phase easily copes with the uncertainty and allows risky decisions. In the stable phase, the Russian model rejects risk, and security, understood as maintaining the achieved state, becomes a priority. A risky situation is a type of uncertain one when the occurrence of possible events is probable and can be estimated. In this situation, it is possible to assess the likelihood of events resulting from the influence of the natural environment, the actions of partners, opponents, etc., which cannot be done in a situation of uncertainty, and this is the key factor that distinguishes between risk and uncertainty.

We define risk as an integral indicator that combines assessments of both the probabilities of implementing a solution and the quantitative characteristics of its consequences. Thus, risk management presupposes, first of all, a conscious and rational choice. Since changing the national model of management takes a lot of time, we suggest to try to change the attitude to risk in modern Russian organizations.
Purpose. The paper describes the experience of implementing a brand new interactive education platform at Novosibirsk State University (NSU). The purpose of the platform is to effectively use all potential communication channels between the object and the subject of knowledge in the system of higher professional education. The modular exposition and education project “Archaeology of Eurasia” developed by the education and research centre “New Archaeology” includes material sources and several digital stands designed following modern trends in education, latest information technologies and many years of experience in teaching archaeology at NSU. Results. The platform is based on primary principles of contemporary teaching approaches, such as brevity, imagery, diversity of sources, interactivity. Its active use in the educational process at the NSU Institute for the Humanities (IH) has shown to improve the quality of teaching and the level of learning skills. The project applies interdisciplinary methodology, which includes the best achievements in the field of educational and information technologies and archaeological science. Conclusion. For the NSU IH this project is a new experience to transfer from the usual classroom to a fundamentally different learning environment which provides an endless variety of opportunities for teaching and learning. Combination of the virtual exposition and real exhibits provides the opportunity to find the optimal algorithm of the interaction between the visitor and the expositional and educational space.
developed on the basis of a Tesla transformer with lumped secondary capacitor bank. The circuit with the lumped capacitor bank allows transferring a greater amount of energy to the discharge circuit as compared with the Marks-surge generator for more effective operation with remote X-ray tubes connected by coaxial cables.

This paper describes the operation principles and design features of the device for single pulse X-raying of explosive and high-speed processes

The device equipped with multiple X-ray tubes provides simultaneous X-raying of extended or spaced objects, stereo imaging, or few-projection tomography.
Hihg-power flows of plasma cause mechanical destruction of materials via non-uniform deformation and stresses.

The possibility of synchrotron radiation scattering diagnostics of deformation is discussed. The experiments at the new scattering station "Plasma" on VEPP-4M demonstrated the measurements of change in the diffraction angle during pulsed heating.
A search for supersymmetry in events with large missing transverse momentum, jets, and at least one hadronically decaying $\tau$-lepton is presented. Two exclusive final states with either exactly one or at least two $\tau$-leptons are considered.

The analysis is based on proton-proton collisions at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 36.1 fb$^{-1}$ delivered by the Large Hadron Collider and recorded by the ATLAS detector in 2015 and 2016.

No significant excess is observed over the Standard Model expectation. At 95% confidence level, model-independent upper limits on the cross section are set and exclusion limits are provided for two signal scenarios: a simplified model of gluino pair production with $\tau$-rich cascade decays, and a model with gauge-mediated supersymmetry breaking (GMSB). In the simplified model, gluino masses up to 2000 GeV are excluded for low values of the mass of the lightest supersymmetric particle (LSP), while LSP masses up to 1000 GeV are excluded for gluino masses around 1400 GeV. In the GMSB model, values of the supersymmetry-breaking scale are excluded below 110 TeV for all values of $\tan\beta$ in the range $2 \leq \tan\beta \leq 60$, and below 120 TeV for $\tan\beta>30$.