Hengzongshu/ArticleAgent huggingface dataset:
Background . the presence of functionally significant intron mutations in the TP53 gene was demonstrated in experiments in vitro and on samples of patients with some variants of non-Hodgkin’s lymphomas. to date, the studies of TP53 in tumor tissue of patients with diffuse large B-cell lymphoma (dlBCl) have been focused on the mutations in 5–8 exons of the gene. For these reasons, further studies of the spectrum of changes in the intron sequences of the TP53 gene and the determination of their functional effect in dlBCl are required.

Description . We present two case reports that are of interest as the cases for detection of functionally significant intron TP53 mutations in dlBCl tissue, first published in the Russian scientific literature. the first clinical case of dlBCl was clinically characterized by extranodal tumor at the onset of the disease, severe symptoms of tumor intoxication, high paraclinical tumor activity, and early hemoblastosis recurrence. the second case of dlBCl was characterized by initially massive tumor lesion, rapidly progressive course of the disease, severe symptoms of tumor intoxication, high paraclinical tumor activity and poor response to therapy with subsequent generalization of lymphoma.

Conclusion . Mutations in the TP53 gene are the driver of the tumor process, serve not only as a marker of aggressive tumor progression, but also as an independent predictor of reduced sensitivity to treatment. the presented clinical cases show that an in-depth analysis of the results of the TP53 sequencing in tumors and functional assessment of all detected changes, including changes in the introns of the gene and involving in silico analysis techniques, are necessary.
In this paper, the initial stages of local anodic oxidation (LAO) process initiated by AFM probe are studied on the wide (∼100μm) terraces of the atomic-smooth Si (111) surface when creating dense array of local oxidation points.

The dependence of LAO points height on the value of voltage initiating the oxidation is found to have a pronounced step-like feature with a characteristic period of 0.7 ± 0.1 nm.

The presented analysis shows for the first time the realization of the step-layer mechanism of anodic oxide growth on the Si (111) surface.
The modeling of the Couette flow in a circular gap between coaxial cylinders is considered, including rarefied gas conditions at large Knudsen numbers.

When developing the experimental facility for this purpose, the geometric sizes were determined taking into account minimum deviation of the velocity profile in the gap from the linear one in the case of laminar flow regime, and also to prevent the formation of Taylor-Görtler vortices with the chosen flow parameters. A series of tests was performed using the hot-wire at atmospheric pressure.

It was cofirmed the operability of the facility itself and satisfactory matching of the hot-wire calibration data using the proposed method in the Couette flow and standard data obtained in the DISA calibration wind tunnel. Preliminary data for influence the Knudsen number on the heat transfer between the hot-wire probe and flow.
The energy sector of Russia is one of the most potent in the world - it is the second in extraction of oil and gas, the third for total output of fuel and energy resources. While exporting nearly 45% of its total production of energy resources, Russia produces more energy per capita than most other countries - 5 times higher the global average and 3 times higher than the average level for OECD countries. The energy sector of Siberia represents the crucial part of the country’s energy sector. Over decades, the energy resources of the region massively contributed to the Russian federal budget and brought in a major part of hard currency from export trade. In the current conditions of existing geopolitical challenges and expected global demand for energy resources, it is much more of a priority for Russia not to raise the output of fuel and energy resources but to improve the overall quality and reliability of the whole energy supply system, increase the depth of mineral fuel, including solid fuel and waste recycling.
Within the framework of stochastic reactive molecular dynamics simulations a statistical method for generating fluorinated graphene structures with desirable fluorine distribution is developed. Electronic transport properties of fluorinated graphene in a wide range of functionalization degrees and system ordering are investigated.

A strong correlation between irregularities in fluorine distribution and electronic properties is found. In particular, proposed consideration allows for the reproduction of both the experimentally observed electron–hole asymmetry in transport properties of fluorinated graphene and a recently revealed conductivity peak at 10% fluoride content.
The article presents the results of measuring the temperature distribution parameters based on planar laser-induced fluorescence (PLIF) of the hydroxyl radical (OH) upon excitation of the transition (1–0) of the A 2 ∑ + – X 2 ∏ system. Thermometry is based on registration of the ratio of the radiation intensity of the transition (2–0) and transitions (0–0), (1–1). For the most frequent excitation lines Q 2 (7), Q 1 (8), R 1 (14), P 1 (2), numerical simulation of fluorescence spectra was performed using the LASKIN software. In this work, the measurement procedure for the laminar pre-mixed Bunsen flame of a methane-air mixture was experimentally worked out. It was shown that the maximum sensitivity of the signal to temperature changes is achieved when the Q 1 (8) transition is excited. It was found that quenching of fluorescence has a negligible effect on the accuracy of temperature measurement.
We search for CP violation in neutral charm meson decays using a data sample with an integrated luminosity of 966 fb^-1 collected with the Belle detector at the KEKB e+e- asymmetric-energy collider. The asymmetry obtained in the rate of D^0 and D^0-bar decays to the pi^0 pi^0 final state, [-0.03+-0.64(stat)+-0.10(syst)]%, is consistent with no CP violation. This constitutes an order of magnitude improvement over the existing result. We also present an updated measurement of the CP asymmetry in the D^0 -> K_S pi^0 decay: A_{CP}(D^0 -> K_S pi^0) = [-0.21+-0.16(stat)+-0.07(syst)]%.
We have used a stepwise increase in ligand complexity approach to estimate the relative contributions of the nucleotide units of DNA containing 7,8-dihydro-8-oxoguanine (oxoG) to its total affinity for human 8-oxoguanine DNA glycosylase (OGG1) and construct thermodynamic models of the enzyme interaction with cognate and non-cognate DNA. Non-specific OGG1 interactions with 10–13 nt pairs within its DNA-binding cleft provides approximately 5 orders of magnitude of its affinity for DNA (ΔG° approximately −6.7 kcal/mol). The relative contribution of the oxoG unit of DNA (ΔG° approximately −3.3 kcal/mol) together with other specific interactions (ΔG° approximately −0.7 kcal/mol) provide approximately 3 orders of magnitude of the affinity. Formation of the Michaelis complex of OGG1 with the cognate DNA cannot account for the major part of the enzyme specificity, which lies in the kcat term instead; the rate increases by 6–7 orders of magnitude for cognate DNA as compared with non-cognate one. The kcat values for substrates of different sequences correlate with the DNA twist, while the KM values correlate with ΔG° of the DNA fragments surrounding the lesion (position from −6 to +6). The functions for predicting the KM and kcat values for different sequences containing oxoG were found.
Background Anopheles coluzzii and An. arabiensis belong to the An. gambiae complex and are among the major malaria vectors in Sub-Saharan Africa. However, chromosome-level reference genome assemblies are still lacking for these medically important mosquito species.

Findings In this study, we produced de novo chromosome-level genome assemblies for An. coluzzii and An. arabiensis using the long-read Oxford Nanopore sequencing technology and the Hi-C scaffolding approach. We obtained 273.4 Mbp and 256.8 Mbp of the total assemblies for An. coluzzii and An. arabiensis , respectively. Each assembly consists of three chromosome-scale scaffolds (X, 2, 3), complete mitochondrion, and unordered contigs identified as autosomal pericentromeric DNA, X pericentromeric DNA, and Y sequences. Comparison of these assemblies with the existing assemblies for these species demonstrated that we obtained improved reference-quality genomes. The new assemblies allowed us to identify genomiccoordinates for the breakpoint regions of fixed and polymorphic chromosomal inversions in An. coluzzii and An. arabiensis .

Conclusion The new chromosome-level assemblies will facilitate functional and population genomic studies in An. coluzzii and An. arabiensis . The presented assembly pipeline will accelerate progress toward creating high-quality genome references for other disease vectors.
For every variety of algebras over a field, there is a natural definition of a corresponding variety of dialgebras (Loday-type algebras). In particular, Lie dialgebras are equivalent to Leibniz algebras.

We use an approach based on the notion of an operad to study the problem of finding special identities for dialgebras.

It is proved that all polylinear special identities for dialgebras can be obtained from special identities for corresponding algebras by means of a simple procedure. A particular case of this result confirms the conjecture by Bremner, Felipe, and Sánchez-Ortega [M.R. Bremner, R. Felipe, and J. Sánchez-Ortega, Jordan triple disystems, Comput. Math. Appl. 63 (2012), pp. 1039–1055].
The sulfonated (SO3H-functionalized) carbon nanomaterials were obtained by direct sulfonation of the initial carbon nanofibers and nanotubes. Concentrated sulfuric acid, oleum (20% SO3) and sulfonating mixtures containing 5 wt% MSO4/H2SO4 (98%; M = VO2+, Cu2+, etc.) were used as a sulfating agents. It was shown that the use of MSO4/H2SO4 sulfonating mixtures allows achieving the efficiency of the sulfonation comparable with the case of oleum. Thus, in the case of the most effective sulfonating mixtures containing such ions as VO2+, Cu2+, Fe3+, the values of the sulfur content were 1.2, 1.1 and 1.15 wt%, respectively. The optimal temperature of the sulfonation process was found to be in a range of 180–200 °C. All this provides a high acidity of the obtained materials along with maintaining the textural parameters (specific surface area of ~100 and ~300 m2/g for CNF and CNT, respectively). The structural changes of the materials taking place during the sulfonation process were studied by means of low-temperature nitrogen adsorption, X-ray photoelectron spectroscopy, Raman spectroscopy, high resolution transmission electron microscopy, and both the titrimetric and elemental analyses. According to the data obtained, high efficiency of the sulfonating mixtures is stipulated by the process of oxidative destruction of the surface layer of the carbon material that leads to an increase of its defectiveness thus enhancing the sulfonation efficiency.
Metre-scale plasma wakefield accelerators have imparted energy gain approaching 10 gigaelectronvolts to single nano-Coulomb electron bunches. To reach useful average currents, however, the enormous energy density that the driver deposits into the wake must be removed efficiently between shots. Yet mechanisms by which wakes dissipate their energy into surrounding plasma remain poorly understood. Here, we report ps-time-resolved, grazing-angle optical shadowgraphic measurements and large-scale particle-in-cell simulations of ion channels emerging from broken wakes that electron bunches from the SLAC linac generate in tenuous lithium plasma. Measurements show the channel boundary expands radially at 1 million metres-per-second for over a nanosecond. Simulations show that ions and electrons that the original wake propels outward, carrying 90 percent of its energy, drive this expansion by impact-ionizing surrounding neutral lithium. The results provide a basis for understanding global thermodynamics of multi-GeV plasma accelerators, which underlie their viability for applications demanding high average beam current.
The recently developed Doppler spectroscopy diagnostic has been used to evaluate the height of the ambipolar potential barrier forming in the gas dynamic trap (GDT) plasma between the central cell and the region with a large magnetic expansion ratio beyond the mirror. The diagnostic technique based on the gas jet charge exchange target, allowed to measure the potential profile along the line of sight covering the radial range from the axis to the limiter. The on-axis potential drop was found to be $2.6 \div 3.1$ in units of the central plane electron temperature, which supports the existing theoretical understanding of suppression of electron thermal conductivity in the GDT expander.
We present an algorithm for detecting metaphor in sentences which was used in Shared Task on Metaphor Detection by First Workshop on Figurative Language Processing.

The algorithm is based on different features and Conditional Random Fields.
This article studies a simple 4-dimensional ternary algebra 𝒜 which appears analogously to the quaternions from the Lie algebra 𝔰𝔩(2).

We describe the heights 1 and 2 identities, and the derivations of 𝒜. Based on 𝒜, some ternary enveloping algebras for ternary Filippov algebras are constructed.

Key Words: Composition algebraDerivationEnveloping algebraFilippov algebraIdentityTriple system2000 Mathematics Subject Classification: 17A4017A75
Background: Dendritic cells (DCs) are known to contribute to the pathogenesis of rheumatoid arthritis (RA) through presentation of cartilage glycoprotein, production of proinflammatory cytokines and activation of Th1/Th17 responses. Along with stimulating activity, DCs may exhibit suppressive functions via capacity to induce T cell apoptosis/anergy and to generate regulatory T cells. Since these DCs have potential to control autoreactive T-lymphocytes, the enhancing of tolerogenic properties of DCs seems to be a new important strategy in treatment of RA. However, it remains unclear whether autoreactive T lymphocytes are sensitive to the immunosuppressive effects of DC. Objectives: The aim of our study is to investigate the mechanisms of the inhibitory effect of dexamethasone-modified DCs (dexDCs) in patients with RA on autologous T cells. Methods: Twenty patients with RA with high and moderate activity of disease were recruited in this study. All patients fullfield ACR/EULAR criteria (2010). All studies were performed after receiving informed consent. DCs were generated from blood monocytes culturing for 5 days with GM-CSF and IFN-α in the presence dexamethasone, applied on third day. LPS as maturation stimuli was added on fourth day. The study evaluated the ability of dexDCs to induce T cell apoptosis, inhibit the production of Th1 and Th17 cytokines in auto-mixed leukocytes culture (MLC), induce the activation of T-regulatory cells, and inhibit the purified protein derivative (PPD)-specific immune response. Results: We revealed that dexDCs markedly suppressed the production of IFN-γ and IL-17, while the decreasing of IL-4 and IL-13 was less pronounced. Thus, in comparison with Th2 cells, Th1 and Th17 T lymphocytes were more sensitive to suppressor effects of dexDCs. We also revealed a significant increasing of cells in the stage of late apoptosis (An+Pi+) during the cultivation of autologous T cells with dexDCs. We have also proved the suppressive effect of dexDCs on culture T cells that are co-cultivated with mature DCs (reduction of proliferation from 2700 cpm to 1500 cpm, p=0.0015). In addition, we have shown the ability of dexDCs to induce T-regulatory cells with a phenotype CD4+IL10+Tr1. In conclusion, we have shown the ability of PPD-loaded dexDCs to inhibit the proliferative response of both mature DCS and mature dexDCs-loaded PPD, that indicates the ability of dexDCs to possess antigen-specific suppression. Conclusion: The data obtained indicate that, dexDCs from RA patients have an immunosuppressive effect on autologous T cells through the induction of apoptosis, anergia and activation of T regulatory cells that authorise their application as a DCs-vaccine. Disclosure of Interests: None declared
The results, that obtained by the spectral method with use of integral relations for the problem of linear stability of steady-state shear plane-parallel flows of an inviscid stratified incompressible fluid in the gravity field with respect to plane perturbations in the Boussinesq approximation and without it

are specified, complemented and developed by the most powerful analytical method of the modern mathematical theory of hydrodynamic stability – the second (or direct) Lyapunov method. The illustrative analytical examples of given steady-state flows and small plane perturbations as normal waves imposed on them are constructed. Using the asymptotic method

In both case, the new analytical method made it possible to prove that given steady-state flows of stratified fluid are absolutely unstable in theoretical sense with respect to small plane perturbations and to obtain the sufficient conditions for practical linear instability of considered flows. it is proved that constructed perturbations grow in time irrespective of the fact whether the Miles-Howard and the Miles-type theorems are valid or not.
We report the first observation of the double strange baryon Ξ(1620)^{0} in its decay to Ξ^{-}π^{+} via Ξ_{c}^{+}→Ξ^{-}π^{+}π^{+} decays

based on a 980 fb^{-1} data sample collected with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The mass and width are measured to be 1610.4±6.0(stat)_{-4.2}^{+6.1} (syst) MeV/c^{2} and 59.9±4.8(stat)_{-7.1}^{+2.8}(syst) MeV, respectively. We obtain 4.0σ evidence of the Ξ(1690)^{0} with the same data sample.

These results shed light on the structure of hyperon resonances with strangeness S=-2.
Recent advances in the production of twisted electron beams with a subnanometer spot size offer unique opportunities to explore the role of orbital angular momentum (OAM) in basic atomic processes.

In the present work, we address one of these processes: radiative recombination of twisted electrons with bare ions. Based on the density matrix formalism and the non-relativistic Schrödinger theory, analytical expressions are derived for the angular distribution and the linear polarization of photons emitted due to the capture of twisted electrons into the ground state of (hydrogen-like) ions.

We show that these angular and polarization distributions are sensitive to both, the transverse momentum and the topological charge of the electron beam. To observe in particular the value of this charge, we propose an experiment that makes use of the coherent superposition of two twisted beams.
As described by P. W. Roesky et al. in their Communication on page 5912 ff., it was obtained either from ultrasmall Sb0 nanoparticles or from Sb amalgam.

In the latter case, unprecedented Sm/Sb/Hg intermediates were isolated to give some insight into the formation mechanism of polystibide compounds. In contrast, the reaction of ultrasmall Sb0 nanoparticles with [Cp*2Sm] resulted directly in the polystibide [(Cp*2Sm)4Sb8].

The largest f-element polystibide [(Cp*2Sm)4Sb8], has been synthesized.
Mixed formulations of ultrafine PETN+soda and RDX+soda have low detonation velocity and small critical diameters, which makes them attractive for application to new technological processes, such as welding explosion [1]. The above properties of these formulations are due to the use of nanopowders of PETN and RDX along with a phlegmatizing agent of sodium bicarbonate. The detonation parameters of these mixtures were studied using synchrotron radiation from the VEPP-3 accelerator (Budker Institute of Nuclear Physics). Techniques we developed were applied to the measurement of density distribution in the detonation front and the width of the reaction zone, as well as volume distribution of pressure, density and spread velocities in detonation of cylindrical charges.
The Tunka-Grande and TAIGA-Muon arrays are the part of a single experimental complex, which also includes the Tunka-133 and TAIGA-HiSCORE (High Sensitivity COsmic Rays and gamma Explorer) wide-angle Cherenkov arrays, TAIGA-IACT array (Imaging Atmospheric Cherenkov Telescope) and Tunka-Rex radio antennas array (Tunka Radio Extension). This complex is located in the Tunka Valley (Buryatia Republic, Russia), 50 km from Lake Baikal. It is aimed at investigating the energy spectrum and mass composition of charged cosmic rays in the energy range 100 TeV - 1000 PeV, searching for diffuse gamma rays above 100 TeV and studying local sources of gamma rays with energies above 30 TeV. This report outlines 3 key points. The first is a description of the Tunka-Grande and TAIGA-Muon scintillation arrays. The second part presents preliminary results of the search for diffuse gamma rays with energies above 50 PeV according to the Tunka-Grande data. The third part is devoted to the prospects of the search for diffuse gamma rays with energies above 100 TeV using the TAIGA-Muon array.
Cerebrovascular dysfunction plays a critical role in the pathogenesis of Alzheimer's disease (AD): the most common cause of dementia in the elderly. The involvement of neurovasculature disorders in the progression of AD is now increasingly appreciated, but whether they represent initial factors or late-stage pathological changes during the disease is unclear. Using senescence-accelerated OXYS rats, which simulate key characteristics of sporadic AD, we evaluated contributions of cerebrovascular alterations to the disease development. At preclinical, early, and advanced stages of AD-like pathology, in the hippocampus of OXYS and Wistar (control) rats, we evaluated (i) the blood vessel state by histological and electron-microscopic analyses; (ii) differences in gene expression according to RNA sequencing (RNA-Seq) to identify the metabolic processes and pathways associated with blood vessel function; (iii) the amount of vascular endothelial growth factor (VEGF) by western blot and immunohistochemical analysis. We observed a loss of hippocampal blood vessel density and ultrastructural changes of those blood vessels in OXYS rats at the early stage of AD-like pathology. There were significant alterations in the vessels and downregulation of VEGF with an increased amount of amyloid β1–42 there at the advanced stage of the disease. According to RNA-Seq data analysis, major alterations in cerebrovascular processes of OXYS rats were associated with blood vessel development, circulatory system processes, the VEGF signaling pathway, and vascular smooth muscle contraction. At preclinical and early stages of the AD-like pathology, these processes were upregulated and then downregulated with age. At the advanced stage in OXYS rats, differentially expressed genes (DEGs) were associated with downregulation of cerebrovascular function as compared to Wistar rats. Among the 46 DEGs at the preclinical stage of the disease, 28 DEGs at the early stage, and among 85 DEGs at the advanced stage, using functional analysis and gene network construction, we identified genes (Nos1, P2rx4, Pla2g6, and Bdkrb2) probably playing a significant role in the development of cerebrovascular dysfunction in OXYS rats. Changes in expression of the genes functionally associated with cerebrovascular processes already in the early period of life may contribute to the development of AD-like pathology in OXYS rats.
We study the charge transport mechanism of electron via traps in thermal SiO2 on silicon.

Electron transport is limited by phonon-assisted tunnelling between traps. Charge flowing leads to oxygen vacancies generation, and the leakage current increases. Long-time annealing at high temperatures decreased the leakage current to initial values due to oxygen vacancies recombination with interstitial oxygen.

Taking into account results of ab initio simulations, we found that the oxygen vacancies act as electron traps in SiO2.