Hengzongshu/ArticleAgent huggingface dataset:
Yellow fever is an acute infectious disease of viral nature, the causative agent of which is vector-borne –is transmitted through the bites of infected mosquitoes. Massive epidemics caused by the yellow fever virus are observed in the countries of Africa, South and Central America annually. Imported cases are also registered in non-endemic territories. The review presents the currently available data on the distribution, structure and classification of the yellow fever virus, the identification of its genetic variants depending on the geographical distribution, as well as modern methods of detection and identification of the pathogen in samples taken from sick and dead people. It considers the possibility of using virological, immunoserological and molecular-genetic methods for the diagnosis of yellow fever in different periods from the onset of the disease and in retrospective studies. The lists of diagnostic drugs of domestic and foreign production for the detection of agent markers (antigen, RNA), as well as specific antibodies of IgM and IgG classes, approved for use on the territory of the Russian Federation, are provided. The relevance of further development, improvement and introduction into laboratory practice of reagent kits that allow to detect the yellow fever virus in samples from sick people in a short time, with high efficiency and specificity is demonstrated. This will help to establish a diagnosis promptly and conduct timely anti-epidemic measures, as well as to determine the level of the population stratum immune to the pathogen in endemic regions and evaluate the effectiveness of immunization for the vaccinated contingent.
Исследуется плоский сильный разрыв в полимерной жидкости в рамках реологической модели Виноградова-Покровского. Приводятся соотношения на сильном разрыве. Обосновано существование разрывных стационарных решений задачи без поворота вектора скорости на разрыве и с поворотом (вращательный разрыв). Приведены примеры численных стационарных решений.
We report the results of a high-statistics search for H dibaryon production in inclusive Υ(1S) and Υ(2S) decays.

The results are based on analyses of 102 million Υ(1S) and 158 million Υ(2S) events collected with the Belle detector at the KEKB e(+)e(-) collider.

No indication of an H dibaryon with a mass near the M(H)=2m(Λ) threshold is seen in either the H→Λpπ(-) or ΛΛ decay channels and 90% confidence level branching-fraction upper limits are set that are between one and two orders of magnitude below the measured branching fractions for inclusive Υ(1S) and Υ(2S) decays to antideuterons. Since Υ(1S,2S) decays produce flavor-SU(3)-symmetric final states, these results put stringent constraints on H dibaryon properties.
The study of the chromosome behavior in meiosis of hybrid lines obtained on the base of crossing of common wheat with tetraploid wheat species showed that introgression of alien genetic material into common wheat genome had no negative effect on its meiotic stability. The Number of defective cells was small, not only at the metaphase I stage, but also on the final stage of tetrads. Variation relative to the level of cytological stability between the studied lines is the consequence of differences in the number and localization of the introgression fragments of the genomes of tetraploid wheat in the hybrid genome. The influence of the cytoplasm on the formation of the karyotype of introgression lines of wheat was found.
Despite the fact that most young patients with hyperglycemia are diagnosed with type 1 (T1DM) and type 2 (T2DM) diabetes, up to 10 % of all cases of the disease are MODY diabetes. The most common types of MODY are GCK-MODY and HNF1A-MODY, therefore the investigation of their clinical and laboratory characteristics, including lipid spectrum indicators is of high clinical significance.

The aim of this research work was to study the values of lipid spectrum indicators in patients diagnosed with GCK-MODY and HNF1A-MODY at the age from 18 to 45 years. Lipid profile parameters were investigated in 56 patients aged 18 to 45 years with diagnosed GCK-MODY and HNF1A-MODY by molecular genetic tests, matched by sex, age and body mass index (BMI).

No statistically significant differences were found for any of the indicators, however, in patients with HNF1A-MODY, the decrease in HDL-C is determined significantly more often than in GCKMODY. Thus, the group of persons with MODY differs in the level of lipid profile indices depending on the type of MODY.
Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.
The method for simultaneous measurement of pressure and average mass flow rate in the dynamic recording mode in the conditions of the T-313 wind tunnel of ITAM SB RAS is presented.

Experimental studies were carried out in the mode M = 2.04, Re1 = (15-25)·106, and T0 = 283 K. Measurement was carried out in the near field of a sonic boom. Distributions of average mass flow rate were measured using a constant-resistance thermoanemometer CTA-2016 (v.2).
During the semicentennial history of Computer Science and Information Technologies, several thousands of computer languages have been created.The computer language universe includes languages for different purposes (programming, specification, modeling, etc.).In each of these branches of computer languages it is possible to track several approaches (imperative, declarative, object-oriented, etc.), disciplines of processing (sequential, non-deterministic, distributed, etc.), and formalized models, such as Turing machines or logic inference machines.Computer language paradigms are the basis for classification of the computer languages.They are based on joint attributes which allow us to differentiate branches in the computer language universe.We have presented our computer-aided approach to the problem of computer language classification and paradigm identification in a recent paper Development of the Computer Language Classification Portal (Proc. of Ershov Informatics Conference PSI-2011, Lect.Not. in Comp.Sci., v.7162).In the present paper we discuss new developments of our project: (1) the pre-alpha version of the Portal is online, and (2) the reasoner is a model checking engine for a paraconsistent (inconsistencytolerant) description logic.
Recent experiments on the injection of kiloampere electron beams into a magnetized plasma at the GOL-PET facility have shown that the power of sub-terahertz radiation escaping from the plasma along the magnetic field increases by more than an order of magnitude if strong transverse density gradients are preliminarily created in the plasma. In this paper, the influence of transverse in homogeneities of plasma density on the efficiency of electromagnetic radiation generation near the harmonics of the plasma frequency is studied using particle-in-cell simulations. Simulations performed for the real relative density of the beam and the real spatial scales of the in homogeneity show that the beam instability develops only in the density wells, and the small transverse size of its localization comparable with the wavelength contributes to a more efficient conversion of unstable oscillations into electromagnetic ones. Despite the fact that radiation at the plasma frequency is blocked across the leading magnetic field, it can leave the generation region with the decrease of the plasma density in the longitudinal direction.
The search for markers of predisposition to atherosclerosis development is very important for early identification of individuals with a high risk of cardiovascular disease. The aim of the present study was to investigate the association of mitochondrial DNA mutations with carotid intima-media thickness and to determine the impact of mitochondrial heteroplasmy measurements in the prognosis of atherosclerosis development. This cross-sectional, population-based study was conducted in 468 subjects from the Novosibirsk region. It was shown that the mean (carotid intima-media thickness) cIMT correlated with the following mtDNA mutations: m.15059G>A (r = 0.159, p = 0.001), m.12315G>A (r = 0.119; p = 0.011), m.5178C>A (r = 0.114, p = 0.014), and m.3256C>T (r = 0.130, p = 0.011); a negative correlation with mtDNA mutations m.14846G>A (r = −0.111, p = 0.042) and m.13513G>A (r = −0.133, p = 0.004) was observed. In the linear regression analysis, the addition of the set of mtDNA mutations to the conventional cardiovascular risk factors increased the ability to predict the cIMT variability from 17 to 27%. Multi-step linear regression analysis revealed the most important predictors of mean cIMT variability: age, systolic blood pressure, blood levels of total cholesterol, LDL and triglycerides, as well as the mtDNA mutations m.13513G>A, m.15059G>A, m.12315G>A, and m.3256C>T. Thus, a high predictive value of mtDNA mutations for cIMT variability was demonstrated. The association of mutation m.13513G>A and m.14846G>A with a low value of cIMT, demonstrated in several studies, represents a potential for the development of anti-atherosclerotic gene therapy.
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses.

Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates.

Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
There has been remarkable recent progress in engineering high-dielectric constant two dimensional (2D) materials, which are being actively pursued for applications in nanoelectronics in capacitor and memory devices, energy storage, and high-frequency modulation in communication devices. Yet many of the unique properties of these systems are poorly understood and remain unexplored.

Here we report a numerical study of hopping conductivity of the lateral network of capacitors, which models two-dimensional insulators, and demonstrate that 2D long-range Coulomb interactions lead to peculiar size effects.

We find that the characteristic energy governing electronic transport scales logarithmically with either system size or electrostatic screening length depending on which one is shorter. Our results are relevant well beyond their immediate context, explaining, for example, recent experimental observations of logarithmic size dependence of electric conductivity of thin superconducting films in the critical vicinity of superconductor-insulator transition where a giant dielectric constant develops. Our findings mark a radical departure from the orthodox view of conductivity in 2D systems as a local characteristic of materials and establish its macroscopic global character as a generic property of high-dielectric constant 2D nanomaterials.
The temperature profiles across a liquid–gas layers at normal atmospheric conditions are measured for water and ethanol. A thin liquid layer is locally heated from the bottom and evaporates from the liquid–gas interface. Micro-thermocouple with the sensor element thickness of 3 μm is used for measurements.

It is shown that the temperature profile has a different character for different liquids.
An experimental study was carried out to investigate heat transfer during the coalition of two drops of the same volume. The falling of a water drop to other drop sitting on a heated horizontal foil made of constantan with a thickness of 25 μm from a distance of 10 mm was recorded with a high-speed video camera. An infrared scanner was used to measure the temperature field on the surface of the foil. Measurements taken with the infrared scanner will be used to determine the heat flux density in the region of the dynamic contact wetting line at the coalition of drops.
The process of dog domestication likely involved at least two functional stages. The initial stage occurred when subpopulations of wolves became synanthropes, benefiting from life nearby or in human environments. The second phase was characterized by the evolution of novel forms of interspecific cooperation and social relationships between humans and dogs. Here, we discuss possible roles of the oxytocin system across these functional stages of domestication. We hypothesize that in early domestication, oxytocin played important roles in attenuating fear and stress associated with human contact. In later domestication, we hypothesize that oxytocin's most critical functions were those associated with affiliative social behavior, social engagement, and cooperation with humans. We outline possible neurobiological changes associated with these processes and present a Siberian fox model of canid domestication in which these predictions can be tested. Lastly, we identify limitations of current studies on the neuroendocrinology of domestication and discuss challenges and opportunities for future research.
Using data samples of $89\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$, $703\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$, and $121\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ collected with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider at center-of-mass energies 10.52 GeV, 10.58 GeV, and 10.876 GeV, respectively, we study the exclusive reactions ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\omega}{\ensuremath{\pi}}^{0}$, ${K}^{*}(892)\overline{K}$, and ${K}_{2}^{*}(1430)\overline{K}$. (Charge-conjugate modes are included implicitly.) Significant signals of $\ensuremath{\omega}{\ensuremath{\pi}}^{0}$, ${K}^{*}(892{)}^{0}{\overline{K}}^{0}$, and ${K}_{2}^{*}(1430{)}^{\ensuremath{-}}{K}^{+}$ are observed for the first time at these energies, and the energy dependencies of the cross sections are presented. On the other hand, no significant excesses for ${K}^{*}(892{)}^{\ensuremath{-}}{K}^{+}$ and ${K}_{2}^{*}(1430{)}^{0}{\overline{K}}^{0}$ are found, and we set limits on the cross section ratios ${R}_{\mathrm{VP}}=\frac{{\ensuremath{\sigma}}_{B}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{*}(892{)}^{0}{\overline{K}}^{0})}{{\ensuremath{\sigma}}_{B}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{*}(892{)}^{\ensuremath{-}}{K}^{+})}>4.3$, 20.0, and 5.4, and ${R}_{\mathrm{TP}}=\frac{{\ensuremath{\sigma}}_{B}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}_{2}^{*}(1430{)}^{0}{\overline{K}}^{0})}{{\ensuremath{\sigma}}_{B}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}_{2}^{*}(1430{)}^{\ensuremath{-}}{K}^{+})}<1.1$, 0.4, and 0.6, for center-of-mass energies of 10.52 GeV, 10.58 GeV, and 10.876 GeV, respectively, at the 90% C.L.
The insulin/insulin-like growth factor signaling (IIS) pathway is one of the key elements in an organism’s response to unfavourable conditions. The deep homology of this pathway and its evolutionary conservative role in controlling the carbohydrate and lipid metabolism make it possible to use Drosophila melanogaster for studying its functioning.

To identify the properties of interaction of two key IIS pathway components under heat stress in D. melanogaster (the forkhead box O transcription factor (dFOXO) and insulin-like peptide 6 (DILP6), which intermediates the dFOXO signal sent from the fat body to the insulin-producing cells of the brain where DILPs1–5 are synthesized), we analysed the expression of the genes dilp6 , dfoxo and insulin-like receptor gene ( dInR ) in females of strains carrying the hypomorphic mutation dilp6 41 and hypofunctional mutation foxo BG01018 . To reveal the role of identified disruptions in metabolism control and feeding behaviour, we analysed the effect of the dilp6 41 and foxo BG01018 mutations on total lipids content and capillary feeding intensity in imago under normal conditions and under short-term heat stress.

We found that neither mutation influenced dfoxo expression and its uprise under short-term heat stress, but both of them disrupted the stress response of the dilp6 and dInR genes. Both mutations caused an increase in these parameters under normal conditions and prevented decrease in total lipids content following heat stress observed in the control strain. In mutants, feeding intensity was increased under normal conditions; and decreased following short-term heat stress in all studied strains for the first 24 h of observation, and in dilp6 41 strain, for 48 h. Thus, we may conclude that dFOXO takes part in regulating the IIS pathway response to heat stress as well as the changes in lipids content caused by heat stress, and this regulation is mediated by DILP6. At the same time, the feeding behaviour of imago might be controlled by dFOXO and DILP6 under normal conditions, but not under heat stress.
The feasibility of generating surface plasmon polaritons carrying orbital angular momentum ("vortex plasmons") on cylindrical conductors by an end-fire coupling technique in the spectral range from 8.5 to 141 μm (~ 2-40 THz) is considered. The front face of the cylinder is illuminated by Bessel beams formed using binary spiral phase axicons, or annual vortex beams formed in the focal plane of an additional lens. Graphs are constructed that reveal the relationship between the waveguide parameters (conductor diameter, which is equal to the diameter of the illuminating beam, and the “twist” angle of the plasmon) and the axicon parameters (the ratio of the axicon period to the radiation wavelength) for the above wavelengths and topological charges of the beams ranging from 1 to 9. The results obtained indicate the possibility of conducting experiments in the long-wavelength range for modeling a plasmon multiplex communication channel.
Purpose. This article considers and analyzes certain features of armament and military science of the Siberian Tatar warriors, that are related to the time of campaign into Siberia of the Russian Cossacks troop under the command of ataman Ermak; these features were mentioned and researched according to data of the Russian Siberian chronicle sources by famous scientist, historian of the 18th Century, academician Gerhard Friedrich Müller.

Results. It is pointed out, that several parts of the Siberian Tatar ruling elite were familiar with firearm and artillery action, and even tried unsuccessful to use artillery pieces, gained during a previous period in Kazan, against the Cossacks in the course of hostilities. However, there were no skilled artillerists among Siberian Tatars who could fire off their artillery pieces. Quite possibly, effective possession of firearms and artillery ensured the definite military superiority to the Cossacks at the time of military clashes with Siberian Tatar warriors during all time of the Cossack troop campaign into Siberia, led by ataman Ermak. Bitter disagreements and struggle for power, among different groups of Siberian Tatar nobility weaken its confronting of the Cossack troop. Gerhard Friedrich Müller drew on varied informative data, contained in the Russian Siberian annalistic historical sources, where it is described how the campaign of the Cossack troop, led by famous ataman Ermak, via mountain range of the Urals into Western Siberia to the territory of the Tatar Khanate of Siberia. That campaign took place upon the initiative of wealthy merchant clan of the Stroganovs.

Conclusion. Several historical events are traced, that are related to the time of this campaign. Several substantive historical reasons are identified, including above all the dissociation among the Siberian Tatar elites, that did not allow to successfully confront the Cossacks in the struggle for preservation of the Tatar Khanate of Siberia.
Results of thermodynamic calculations of the interactions of radon waters from the Zaeltsovsky field with the minerals of host rocks are presented for the first time. It was established that waters under study are supersaturated with respect to calcite and siderite, and to a smaller extent with respect to magnesite and dolomite. No saturation of radon waters with respect to primary aluminosilicate minerals (albite, anortite, microcline, ferrosilite) is observed. The points are located in the fields of stability of clayey minerals (kaolinite, Ca- and Mg-montmorillonite, Fe-sepiolite), gibbsite and leptochlorite. In the evolution of the water-rock system, they correspond to the siallite type of interaction with rocks.
Properties of non-canonical GC Base Pairs and their relation with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the Transient GC Wobble Base Pairs in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms with participation of 5-methylcytosine is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, asymmetric character of these breaks, and an increase in the frequency of breaks in CpG after cytosine methylation.