Hengzongshu/ArticleAgent huggingface dataset:
At present, it is known that the pathogenesis of this disease involves not only a pathological variant of low-density lipoprotein receptor and its ligands (apolipoprotein B, proprotein convertase subtilisin/kexin type 9 or low-density lipoprotein receptor adaptor protein 1), but also lipids, including sphingolipids, fatty acids, and sterols. The genetic cause of familial hypercholesterolemia is unknown in 20%–40% of the cases.

The genes STAP1 (signal transducing adaptor family member 1), CYP7A1 (cytochrome P450 family 7 subfamily A member 1), LIPA (lipase A, lysosomal acid type), ABCG5 (ATP binding cassette subfamily G member 5), ABCG8 (ATP binding cassette subfamily G member 8), and PNPLA5 (patatin like phospholipase domain containing 5), which can cause aberrations of lipid metabolism, are being evaluated as new targets for the diagnosis and personalized management of familial hypercholesterolemia.

This review addresses the contribution of some genes to the phenotype of familial hypercholesterolemia.
We study stationary solutions in the differential kinetic equation, which was introduced in Dyachenko A et al (1992 Physica D 57 96–160) for description of a local dual cascade wave turbulence.

Analysis of the steady-state spectrum is based on a phase-space analysis of orbits of the underlying dynamical system. The orbits of the dynamical system demonstrate the blowup behaviour which corresponds to a 'sharp front' where the spectrum vanishes at a finite wave number.

We give a full classification of single-cascade states in which there is a finite flux of only one conserved quantity. The roles of the Kolmogorov–Zakharov and thermodynamic scaling as intermediate asymptotic, as well as of singular solutions, are discussed.
Continental runoff is one of the major sources of the Arctic freshwater budget. As is generally known, it influences water column stratification and maintains Arctic halocline, which isolates the sea ice and the cold, fresh upper layer from the warmer, saltier Atlantic waters of the Arctic Ocean. An increase in river runoff was observed in recent years. It is suggested that this will have an impact on Arctic water mass transformations. However, few details are known regarding river freshwater export to the Central Arctic Basin. It is assumed that river water pathways in vast shelf seas and deep basins are closely related to atmospheric variability. In this study, we use three-dimensional coupled regional ocean-ice model simulations forced by atmospheric reanalysis data to investigate the change in Siberian rivers freshwater pathways in the Arctic Ocean due to the variability of atmospheric dynamics. A numerical experiment with an increasing runoff of the largest Siberian rivers is carried out. The consequences of adding freshwater to particular regions of the Arctic Ocean are analysed.
Simulation of a blood flow under normality as well as under pathology is extremely complex problem of great current interest both from the point of view of fundamental hydrodynamics, and for medical applications.

This paper proposes a model of Van der Pol - Duffing nonlinear oscillator equation describing relaxation oscillations of a blood flow in the cerebral vessels. The model is based on the patient-specific clinical experimental data flow obtained during the neurosurgical operations in Meshalkin Novosibirsk Research Institute of Circulation Pathology. The stability of the model is demonstrated through the variations of initial data and coefficients.

It is universal and describes pressure and velocity fluctuations in different cerebral vessels (arteries, veins, sinuses), as well as in a laboratory model of carotid bifurcation. Derived equation describes the rheology of the 'blood stream - elastic vessel wall gelatinous brain environment' composite system and represents the state equation of this complex environment.
Vaviloid spike branching, also called sham ramification, is a typical trait of Triticum vavilovii Jakubz. and is characterized by a lengthening of the spikelet axis. In this article, we present the results of a study of three triticale-wheat hybrid lines with differences in terms of the manifestation of the vaviloid spike branching. Lines were obtained by crossing triticale with hexaploid wheat, T. aestivum var. velutinum. The parental triticale is a hybrid of synthetic wheat (T. durum × Ae. tauschii var. meyrei) with rye, S. cereale ssp. segetale. Line 857 has a karyotype corresponding to hexaploid wheat and has a spike morphology closest to normal, whereas Lines 808/1 and 844/4 are characterized by the greatest manifestation of vaviloid spike branching. In Lines 808/1 and 844/4, we found the substitution 2RL(2DL). The karyotypes of the latter lines differ in that a pair of telocentric chromosomes 2DS is detected in Line 808/1, and these telocentrics are fused into one unpaired chromosome in Line 844/4. Using molecular genetic analysis, we found a deletion of the wheat domestication gene Q located on 5AL in the three studied hybrid lines. The deletion is local since an analysis of the adjacent gene B1 showed the presence of this gene. We assume that the manifestation of vaviloid spike branching in two lines (808/1 and 844/4) is associated with a disturbance in the joint action of genes Q and AP2L2-2D, which is another important gene that determines spike morphology and is located on 2DL.
Resent experimental and theoretical studies suggested preferential stability of Fe 3 C over Fe 7 C 3 at the condition of the Earth's inner core. Previous studies showed that Fe 3 C remains in an orthorhombic structure with the space group Pnma to 250 GPa, but it undergoes ferromagnetic (FM) to paramagnetic (PM) and PM to nonmagnetic (NM) phase transitions at 6–8 and 55–60 GPa, respectively. These transitions cause uncertainties in the calculation of the thermoelastic and thermodynamic parameters of Fe 3 C at core conditions.

In this work we determined P‐V‐T equation of state of Fe 3 C using the multianvil technique and synchrotron radiation at pressures up to 31 GPa and temperatures up to 1473 K. A fit of our P‐V‐T data to a Mie‐Gruneisen‐Debye equation of state produce the following thermoelastic parameters for the PM‐phase of Fe 3 C: V 0 = 154.6 (1) Å 3 , K T 0 = 192 (3) GPa, K T ′ = 4.5 (1), γ 0 = 2.09 (4), θ 0 = 490 (120) К, and q = −0.1 (3). Optimization of the P‐V‐T data for the PM phase along with existing reference data for thermal expansion and heat capacity using a Kunc‐Einstein equation of state yielded the following parameters: V 0 = 2.327 cm 3 /mol (154.56 Å 3 ), K T 0 = 190.8 GPa, K T ′ = 4.68, Θ E10 = 305 K (which corresponds to θ 0 = 407 K), γ 0 = 2.10, e 0 = 9.2 × 10 −5 K −1 , m = 4.3, and g = 0.66 with fixed parameters m E 1 = 3 n = 12, γ ∞ = 0, β = 0.3, and a 0 = 0.

This formulation allows for calculations of any thermodynamic functions of Fe 3 C versus T and V or versus T and P . Assuming carbon as the sole light element in the inner core, extrapolation of our equation of state of the NM phase of Fe 3 C suggests that 3.3 ± 0.9 wt % С at 5000 К and 2.3 ± 0.8 wt % С at 7000 К matches the density at the inner core boundary.
We demonstrated how the nonlinear Fourier transform based on the Zakharov-Shabat spectral problem can be used to characterise coherent structures in dissipative systems. We consider as a particular, albeit important practical example model equation that is widely used to analyse laser radiation and demonstrate that dissipative solitons can be described by a limited number of degrees of freedom { discrete eigenvalues. Our approach can be applied for signal processing in a number of optical systems, from lasers to micro-resonators.
A full list of entire and finite valued solutions of the three body problem in the form of functions, depending on a time variable, is established. All the entire and finite valued solutions are among the solutions of Euler and Lagrange.
Background .Heat shock effects can initiate apoptosis of oocytes and corpus luteum cells in mammalian ovaries. During folliculogenesis, follicular apoptosis is regulated by Bcl-2 and BAX proteins which are key effectors of granular cell death. Mechanisms of disruption of the ovarian corpus luteum development under heat stress remain largely unclear.

Aim of the research : to identify the expression features of anti-apoptotic Bad and proapoptotic Bcl-2 proteins in the rat ovarian luteocytes in the acute (by day 3) and recovery (by days 7 and 14) periods after a single exposure of experimental hyperthermia (EH) (rectal temperature 43.5 °C). Materials and methods . The expression of Bad and Bcl-2 was determined immunohistochemically using an indirect two-stage streptavidin-biotin method.

Results . On day 3 after EH, the expression areas of both Bad and Bcl-2 increased 2-fold, but the ratio of Bcl-2/Bad areas did not change, indicating that the intensity of apoptosis along the mitochondrial pathway in luteocytes in the acute period was maintained within physiological values. On day 7, the Bad and Bcl-2 expression areas remained at the level of day 3, but the Bcl-2/Bad index decreased, indicating the activation of the apoptosis internal pathway in the ovarian corpus luteum cells. By day 14, the protein expression areas decreased (Bad – by 1.7 times, Bcl-2 – by 3.2 times) compared to the acute period, and the Bcl-2/Bad index decreased by 2 times compared to the control and the acute period group. Conclusion . The observed predominance of proapoptotic Bad protein over antiapoptotic Bcl-2 in luteocytes on day 14 after EH indicates the anti-apoptotic protection violation, which leads to the apoptosis mitochondrial pathway activation of the latter. A decrease in Bcl-2 expression can be regarded as a manifestation of the defective luteocytes removal mechanism and the body’s desire to normalize the ovarian-uterine cycle disrupted by high temperature exposure.
Background In this paper we describe an analysis of the size evolution of both protein domains and their indels, as inferred by changing sizes of whole domains or individual unaligned regions or "spacers". We studied relatively early evolutionary events and focused on protein domains which are conserved among various taxonomy groups.

Results We found that more than one third of all domains have a statistically significant tendency to increase/decrease in size in evolution as judged from the overall domain size distribution as well as from the size distribution of individual spacers. Moreover, the fraction of domains and individual spacers increasing in size is almost twofold larger than the fraction decreasing in size.

Conclusion We showed that the tolerance to insertion and deletion events depends on the domain's taxonomy span. Eukaryotic domains are depleted in insertions compared to the overall test set, namely, the number of spacers increasing in size is about the same as the number of spacers decreasing in size. On the other hand, ancient domain families show some bias towards insertions or spacers which grow in size in evolution. Domains from several Gene Ontology categories also demonstrate certain tendencies for insertion or deletion events as inferred from the analysis of spacer sizes.
This article is dedicated to modeling the end-stopped neuron. This type of neuron gives the maximum response at the end of the line and is used to refine the edge. The article provides an overview of different models of end-stopped neurons.

I have proposed a simpler and more accurate model of an end-stopped neuron based on the use of Gabor filters in antiphase. For this purpose, the models of simple and complex cells whose output is used in the proposed model are also described. Simple cells are based on the use of a Gabor filter, the parameters of which are also described in this article.

The proposed model has shown its effectiveness.
The article analyzes the current problems of investment in the intellectual property market in Russia. The world experience of investing in an intellectual product is considered. The actual statistics on investment activity in the intellectual property market of Russia is given. The correlation analysis of the influence of investment activity on patent activity in Russia is carried out.
The double-square-root (DSR) equation can be viewed as a Hamilton-Jacobi equation describing kinematics of downward data continuation in depth. It describes simultaneous propagation of source and receiver rays which allows computing reflection wave prestack traveltimes (for multiple sources) in a one run thus speeding up solution of the forward problem.

Here we give and overview of different alternative forms of the DSR equation which allows stepping in two-way time and subsurface offset instead of depth. Different forms of the DSR equation are suitable for computing different types of waves including reflected, head and diving waves. We develop a WENO-RK numerical scheme for solving all mentioned forms of the DSR equation.

Finally the extended exploding reflector concept can be used for computing prestack traveltimes while initiating the numerical solver as if a reflector was exploding in extended imaging space.
Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (≤60, 61–70, 71–80, and >80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased ( P <0.001) from 4.4 (95% CI, 4.0–4.7) to 86.3 (76.1–96.5) for all-cause mortality and from 4.1 (3.9–4.6) to 59.8 (51.0–68.7) for cardiovascular events, whereas hazard ratios per 20-mm Hg increment in systolic out-of-office blood pressure decreased ( P ≤0.0033) from 1.42 (1.19–1.69) to 1.09 (1.05–1.12) and from 1.70 (1.51–1.92) to 1.12 (1.07–1.17), respectively. These age-related trends were similar for out-of-office diastolic pressure and were generally consistent in both sexes and across ethnicities. In conclusion, adverse outcomes were directly associated with out-of-office blood pressure in adults. At young age, the absolute risk associated with out-of-office blood pressure was low, but relative risk high, whereas with advancing age relative risk decreased and absolute risk increased. These observations highlight the need of a lifecourse approach for the management of hypertension.
The numerical solution of the 2D forward problem is based on the finite-element method and the Cholesky decomposition for solving a system of linear algebraic equations (SLAE).

Software implementations of the algorithm used the NVIDIA CUDA technology and computing libraries are made, allowing us to perform decomposition of SLAE and find its solution on central processor unit (CPU) and graphics processor unit (GPU).

The calculation time is analyzed depending on the matrix size and number of its non-zero elements. We estimated the computing speed on CPU and GPU, including high-performance heterogeneous CPU-GPU computing. Using the developed algorithm, we simulated resistivity data in realistic models.
Coagulation technique was applied for preparation of multiwall carbon nanotube- (MWNT-)containing polystyrene (PSt) composite materials with different MWNT loading (0.5–10 wt.%). Scanning and transmission electron microscopies were used for investigation of the morphology and structure of produced composites. It was shown that synthesis of MWNT/PSt composites using coagulation technique allows one to obtain high dispersion degree of MWNT in the polymer matrix. According to microscopy data, composite powder consists of the polystyrene matrix forming spherical particles with diameter ca. 100–200 nm, and the surface of MWNT is strongly wetted by the polymer forming thin layer with 5–10 nm thickness. Electrical conductivity of MWNT/PSt composites was investigated using a four-probe technique. Observed electrical percolation threshold of composite materials is near to 10 wt.%, mainly due to the insulating polymer layer deposited on the surface of nanotubes. Electromagnetic response of prepared materials was investigated in broadband region (0.01–4 and 26–36 GHz). It was found that MWNT/PSt composites are almost radiotransparent for low frequency region and possess high absorbance of EM radiation at higher frequencies.
We report new paleomagnetic and geochronological data for rocks of the Franz Josef Land archipelago and generalize available information about the paleomagnetism of the Barents Sea continental margin as applied to the issues of the Mesozoic Arctic tectonics. Specifically, the obtained age estimates are indicative of a brief episode of mantle plume magmatism at the Barremian–Aptian boundary (Early Cretaceous). The paleomagnetic data shows that intraplate magmatism formations in the High Arctic, including the Franz Josef Land traps, are nothing else than a trace of the Iceland plume on the migrating tectonic plates of the region. Thus, the Iceland plume was geographically stationary for at least the last 125 Myr. Our paleotectonic reconstructions suggest a direct connection of the intraplate strike-slip systems of the Eurasian continent with the configuration and subsequent evolution mode of Mesozoic marginal basins and spreading axes during the initial opening stage of the Arctic Ocean.
A positive list (list of positive integers) is protographic if its merger with all but finitely many positive graphic lists is graphic. Define the family ${\cal P}_s$ of $s$-protogaphic lists by letting ${\cal P}_0$ be the family of positive graphic lists and letting ${\cal P}_s$ for $s>0$ be the family of positive lists whose merger with all but finitely many lists in ${\cal P}_{s-1}$ is in ${\cal P}_{s-1}$. The main result is that $X\in{\cal P}_s$ if and only if $t(X)\in {\cal P}_{s-1}$, where $t(X)$ is the list obtained from $X$ by subtracting one from each term of $X$ (deleting those that become $0$) and appending a 1 for each term of $X$. A corollary is that the maximum number of iterations to reach a graphic list from an $n$-term even list with sum $2k$ is $k-n+1$ (when $k\ge n$), achieved by the unique such list having one term larger than 1.
We introduce a new method of the fabrication of surface nanoscale axial photonic (SNAP) microresonators through strong bending of an optical fiber.

We experimentally demonstrate that geometric deformation and refractive index variation induced by bending is sufficient for the formation of a SNAP bottle resonator with nanoscale effective radius variation (ERV) along the fiber axis. In our experiment, we bend the optical fiber into a loop and investigate the properties of the fabricated tunable bottle resonator as a function of the loop dimensions.

We find that the introduced ERV is approximately proportional to the local curvature of the loop, while the ERV maximum is proportional to the maximum of the loop curvature squared. The advantages of the demonstrated method are its simplicity, robustness, and ability to mechanically tune introduced resonant structures. This is of crucial importance for the creation of robust and tunable SNAP devices for applications in optical classical and quantum signal processing and ultraprecise sensing.
Stress-strain state horizontal coal seam of finite length

analytical expressions for calculation of tension in coal stratum of terminating length, which is under the influence of overlying breeds and is between two drifts are received. The decision is presented in the form of the sum of a polynom and a convergent series. For determination of coefficients of a row it is not required to solve the infinite systems of the algebraic equations.

It promotes fast numerical finding of the required sizes with an accuracy, sufficient for practice. The given decision can be used for interpretation of data of geomechanical monitoring at combinegouge of coal in the conditions of real time and for monitoring of tension in the developed coal layer for the purpose of prediction of a possibility of mountain emission that still is very relevant problem of safety of mining operations.
The study area has two types of natural water-driven systems: expelled system (geostatic and geodynamic) in the basin centre and infiltration system in the basin margins.

The article presents the study results of hydrodynamic zoning of hydrocarbon reservoirs of the Yamal-Kara depression located in the north West Siberian megabasin.

Piezominimum zones extending along the main oil and gas seeps (Bolshayakheta and Kara megasyneclises) have been found that correspond to the largest petroleum plays (Vankor-Suzunskaya, Bovanenkovskaya, Urengoiskaya and others).
Glycobiology is an underexplored research area in inflammatory bowel disease (IBD), and glycans are relevant to many etiological mechanisms described in IBD. Alterations in N-glycans attached to the immunoglobulin G (IgG) Fc fragment can affect molecular structure and immunological function. Recent genome-wide association studies reveal pleiotropy between IBD and IgG glycosylation.

This study aims to explore IgG glycan changes in ulcerative colitis (UC) and Crohn's disease (CD).IgG glycome composition in patients with UC (n = 507), CD (n = 287), and controls (n = 320) was analyzed by ultra performance liquid chromatography.

Statistically significant differences in IgG glycome composition between patients with UC or CD, compared with controls, were observed. Both UC and CD were associated with significantly decreased IgG galactosylation (digalactosylation, UC: odds ratio [OR] = 0.71; 95% confidence interval [CI], 0.5-0.9; P = 0.01; CD: OR = 0.41; CI, 0.3-0.6; P = 1.4 × 10) and significant decrease in the proportion of sialylated structures in CD (OR = 0.46, CI, 0.3-0.6, P = 8.4 × 10). Logistic regression models incorporating measured IgG glycan traits were able to distinguish UC and CD from controls (UC: P = 2.13 × 10 and CD: P = 2.20 × 10), with receiver-operator characteristic curves demonstrating better performance of the CD model (area under curve [AUC] = 0.77) over the UC model (AUC = 0.72) (P = 0.026). The ratio of the presence to absence of bisecting GlcNAc in monogalactosylated structures was increased in patients with UC undergoing colectomy compared with no colectomy (FDR-adjusted, P = 0.05).The observed differences indicate significantly increased inflammatory potential of IgG in IBD. Changes in IgG glycosylation may contribute to IBD pathogenesis and could alter monoclonal antibody therapeutic efficacy. IgG glycan profiles have translational potential as IBD biomarkers.