Hengzongshu/ArticleAgent huggingface dataset:
The paper deals with the problem of numerical simulation of the modes of pulse air outflow into a vertical pipe, filled with liquids with different physical properties (water, ethanol, glycerol), implemented in the OpenFOAM software package. This problem has a wide range of technical applications, ranging from the modeling of emergency operation of the liquid-metal nuclear reactors to the depressurization of underwater pipelines, functioning of the shipboard technical systems, etc. For obtaining verification data visualization experiments were carried out. The results of numerical simulation and experimental data are in satisfactory agreement.
Background The scent from receptive female mice functions as a signal, which stimulates male mice to search for potential mating partners. This searching behavior is coupled with infection risk due to sniffing both scent marks as well as nasal and anogenital areas of females, which harbor bacteria and viruses. Consideration of host evolution under unavoidable parasitic pressures, including helminthes, bacteria, viruses, etc., predicts adaptations that help protect hosts against the parasites associated with mating. Methods and Findings We propose that the perception of female signals by BALB/c male mice leads to adaptive redistribution of the immune defense directed to protection against respiratory infection risks. Our results demonstrate migration of macrophages and neutrophils to the upper airways upon exposure to female odor stimuli, which results in an increased resistance of the males to experimental influenza virus infection. This moderate leukocyte intervention had no negative effect on the aerobic performance in male mice. Conclusions Our data provide the first demonstration of the adaptive immunological response to female odor stimuli through induction of nonspecific immune responses in the upper respiratory tract.
DHR38 is a member of the steroid receptor superfamily in Drosophila homologous to the vertebrate NGFI-B-type orphan receptors. In addition to binding to specific response elements as a monomer, DHR38 interacts with the USP component of the ecdysone receptor complex in vitro, in yeast and in a cell line, suggesting that DHR38 might modulate ecdysone-triggered signals in the fly.

We characterized the molecular structure and expression of the Dhr38 gene and initiated an in vivo analysis of its function(s) in development. The Dhr38 transcription unit spans more than 40 kb in length, includes four introns, and produces at least four mRNA isoforms differentially expressed in development; two of these are greatly enriched in the pupal stage and encode nested polypeptides. We characterized four alleles of Dhr38: a P-element enchancer trap line, l(2)02306, which shows exclusively epidermal staining in the late larval, pre-pupal and pupal stages, and three EMS-induced alleles.

Dhr38 alleles cause localized fragility and rupturing of the adult cuticle, demonstrating that Dhr38 plays an important role in late stages of epidermal metamorphosis.
Currently, the gold standard of plastic material for infrainguinal artery replacement is still autovein, however, not infrequently the necessity for prostheses arises.The review presents the characteristics of xeno-and allogenic prostheses for lower limb arteries, which have been used in vascular surgery worldwide since 1960-ies till the present.There have been analyzed the clinical results with the bioprostheses, their advantages and disadvantages being discussed.We have shown that the approach based on chemically cross-linked human and animal tissues used for bioprostheses is limited in its further development.We have studied the evolution of tissue engineering vascular grafts (TEVG), and carried out a critical review of current state of the issue, and presented further paths of its development.
The influence of mutations in chromosome 17 upon the segregation of the metacentric and acrocentric homologues in the progeny of female mice heterozygous for Robertsonian translocations Rb(8.17)11em and Rb(16.17)7Bnr was studied.

Genetic analysis indicated that the portion of non-Rb (normal karyotype) progeny from mothers heterozygous for mutations tf, qk, t 12 was weakly different from the 50% Mendelian expected level (55–57%). Introduction of mutations T, Fu Ki , Fu, t 6 into the female genotype caused a stronger segregation distortion and an increase in the portion of progeny with normal karyotype (63–67%).

From the data on embryonic mortality and cytogenetic observations it is concluded that a distortion of equal transmission arises before M II of meiosis. Consequently, the preferential distribution of the metacentric chromosome to the polar body during the first meiotic division is relevant to the observed segregation distortion.
An approach for true-amplitude seismic beam imaging of multicomponent seismic data in 2-D anisotropic elastic media is presented and discussed. Here, the recovered true-amplitude function is a scattering potential.

This approach is a migration procedure based on the weighted summation of pre-stack data. The true-amplitude weights are computed by applying Gaussian beams (GBs). We shoot a pair of properly chosen GBs with a fixed dip and opening angles from the current imaging point towards an acquisition system. This pair of beams is used to compute a true-amplitude selective image of a rapid velocity variation. The total true-amplitude image is constructed by superimposing selective images computed for a range of available dip angles.

The global regularity of the GBs allows one to disregard whether a ray field is regular or irregular. P- and S-wave GBs can be used to handle raw multicomponent data without separating the waves. The use of anisotropic GBs allows one to take into account the anisotropy of the background model.
Free electron laser based on multi-turn microtron-recuperator is currently operates at Novosibirsk. Whole facility is a coherent radiation source with ability of wavelength tuning in adequately wide range. The main parameters of radiation (wavelength and radiation power) are depends on electron beam parameters – its energy, average current, movement trajectory. The system of magnetic elements, in turn, appear to be a main instrument to control over beam movement trajectory. The structure, main parameters of this system, abilities of magnetic elements control system are described in this article.
M(NH3)5Cl][IrCl6], M = Co, Cr, Ru, Rh, and Ir, were proposed as single-source precursors for bimetallic alloys.

Upon heating, compounds show endothermic effect

which can be corresponded with Ir(iv) reduction and ligand exchange.
Using pp collision data corresponding to 1.0 fb(-1) integrated luminosity collected by the LHCb detector, two narrow states are observed in the Λ(b)(0)π(+)π(-) spectrum with masses 5911.97±0.12(stat)±0.02(syst)±0.66(Λ(b)(0) mass) MeV/c(2) and 5919.77±0.08(stat)±0.02(syst)±0.66(Λ(b)(0) mass) MeV/c(2). The significances of the observations are 5.2 and 10.2 standard deviations, respectively. These states are interpreted as the orbitally excited Λ(b)(0) baryons, Λ(b)(*0)(5912) and Λ(b)(*0)(5920).
We report the results of a search for the rare, purely leptonic decay B^{-}→μ^{-}ν[over ¯]_{μ} performed with a 711 fb^{-1} data sample that contains 772×10^{6} BB[over ¯] pairs, collected near the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The signal events are selected based on the presence of a high momentum muon and the topology of the rest of the event showing properties of a generic B-meson decay, as well as the missing energy and momentum being consistent with the hypothesis of a neutrino from the signal decay. We find a 2.4 standard deviation excess above background including systematic uncertainties, which corresponds to a branching fraction of B(B^{-}→μ^{-}ν[over ¯]_{μ})=(6.46±2.22±1.60)×10^{-7} or a frequentist 90% confidence level interval on the B^{-}→μ^{-}ν[over ¯]_{μ} branching fraction of [2.9,10.7]×10^{-7}.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the HTT gene. HD patient-specific induced pluripotent stem cells (iPSCs) represent an excellent model for the disease study. We generated iPSC line from blood mononuclear cells of HD patient with 38 CAG repeats in the HTT exon 1 using integration free episomal plasmids expressing Yamanaka factors. The iPSC line retained the disease causing mutation and expressed pluripotency markers. It also displayed a normal karyotype and the ability to differentiate into derivatives of three germ layers.
In this article, we will present the results of Artin–Markov on braid groups by using the Gröbner–Shirshov basis. As a consequence, we can reobtain the normal form of Artin–Markov–Ivanovsky as an easy corollary. Key Words: Braid groupDiamond lemmaGröbner–Shirshov basisNormal formRewriting systemMathematics Subject Classification: Primary 20F36Secondary 16S15 ACKNOWLEDGMENT Bokut is supported in part by the Russia's Fund for Fundamental Research and the Leading Scientific Schools Fund. The research of the third author is partially supported by a RGC grant (CUHK) #2060297 (05-07). Notes Communicated by A. I. Zelmanov. ∗Dedicated to 80th birthday of Boris Isaakovich Plotkin.
Measurements of b-hadron masses are performed with the exclusive decay modes B+ -> J/psi K+, B0 -> J/psi K*0, B0 -> J/psi K0S, B0_s -> J/psi phi and Lambda_b -> J/psi Lambda using an integrated luminosity of 35 pb-1 collected in pp collisions at a centre-of-mass energy of 7 TeV by the LHCb experiment. The momentum scale is calibrated with J/psi -> mu+mu- decays and verified to be known to a relative precision of 2 x 10^-4 using other two-body decays. The results are more precise than previous measurements, particularly in the case of the B0_s and Lambda_b masses.
Acousto-optic diffraction of terahertz vortex beams was studied for the first time. It was shown that nonpolar liquids are the most promising acousto-optic media in the terahertz range. Possibility of vortex beam wide-angle deflection was demonstrated. Experimental research was performed for cyclohexane, hexane and white spirit. The experiments were carried out at the Novosibirsk free-electron laser.
U–Pb geochronological, trace‐element and Lu–Hf isotopic studies have been made on zircons from ultrahigh‐pressure (UHP) mafic eclogite from the Kumdy‐Kol area, one of the diamond‐facies domains of the Kokchetav Massif (northern Kazakhstan).

The peak eclogitic assemblage equilibrated at > 900 °C, whereas the bulk sample composition displays light rare‐earth element (LREE) and Th depletion evident of partial melting. Zircons from the eclogite are represented by exclusively newly formed metamorphic grains and have U–Pb age spread over 533–459 Ma, thus ranging from the time of peak subduction burial to that of the late post‐orogenic collapse.

The major zircon group with concordant age estimates have a concordia age of 508.1 ±4.4 Ma, which corresponds to exhumation of the eclogite‐bearing UHP crustal slice to granulite‐ or amphibolite‐facies depths. This may indicate potentially incoherent exhumation of different crustal blocks within a single Kumdy‐Kol UHP domain. Model Hf isotopic characteristics of zircons (ε Hf (t) +1.5 to +7.8, Neoproterozoic model Hf ages of 1.02–0.79 Ga) closely resemble the whole‐rock values of the Kumdy‐Kol eclogites and likely reflect in situ derivation of HFSE source for newly formed grains. The ages coupled with geochemical systematics of zircons confirm that predominantly late zircon growth occurred in Th–LREE‐depleted eclogitic assemblage, that experienced incipient melting and monazite dissolution in melt at granulite‐facies depths, followed by amphibolite‐facies rehydration during late‐stage exhumation‐related retrogression.
A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce 13 C-hyperpolarized ethyl acetate for potential biomedical applications.

The Rh/TiO2 catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized 13 C-enriched ethyl acetate-1-13 C detected at 9.4 T. An approximately 14-fold 13 C signal enhancement was detected using circa 50 % parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to 13 C nuclei.

This first observation of 13 C PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.
Being a superluminous supernova, PTF12dam can be explained by a 56 Ni-powered model, a magnetar-powered model, or an interaction model. We propose that PTF12dam is a pulsational pair-instability supernova, where the outer envelope of a progenitor is ejected during the pulsations. Thus, it is powered by a double energy source: radioactive decay of 56 Ni and a radiative shock in a dense circumstellar medium. To describe multicolor light curves and spectra, we use radiation-hydrodynamics calculations of the STELLA code. We found that light curves are well described in the model with 40 M ⊙ ejecta and 20–40 M ⊙ circumstellar medium. The ejected 56 Ni mass is about 6 M ⊙ , which results from explosive nucleosynthesis with large explosion energy (2–3) × 10 52 erg. In comparison with alternative scenarios of pair-instability supernova and magnetar-powered supernova, in the interaction model, all the observed main photometric characteristics are well reproduced: multicolor light curves, color temperatures, and photospheric velocities.
On the basis of recent results, we propose a model for DNA polymerase translocation along DNA. Human immunodeficiency virus reverse transcriptase is taken as an example. According to the model, movement of the enzyme is the result of transition of the enzyme‐bound DNA from the A‐ to B‐form which is accompanied by lengthening of DNA within the binding channel. The driving force of this transition is the increase in water accessibility to the DNA‐binding cleft after dNTP binding. dNTP hydrolysis proceeding during the following chemical step supplies the energy for the reverse B → A transition of DNA. Translocation is considered to be an integral part of the stage of conformational change preceding catalysis and can be described as a worm‐like movement of DNA within the DNA‐binding cleft.
Aim . To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).

Materials and methods . The experimental group included 47 patients with verified moderate primary open-angle glaucoma. The control group consisted of 26 patients with uncomplicated cataract. The levels of MMP-2, -3, -9 were determined with Luminex Performance Human MMP Magnetic Panel 3-plex kit (R&D Systems, USA), the concentration of TIMPs-1, -2, -3, -4 was determined with the Human TIMP Magnetic Luminex Performance Assay 4-plex kit (R&D Systems, USA). The study was carried out using flow-through field fluorometry on a Bio-Plex 200 double-beam laser analyzer (Bio-Rad, USA).

Results . The study showed a statistically significant increase in the levels of matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinases-1, -2, -3, -4 in the aqueous humor of patients with moderate POAG compared with patients with uncomplicated cataract. Conclusion . The obtained data on high concentrations and imbalance in the levels of matrix metalloproteinases and their tissue inhibitors in the aqueous humor of patients with moderate POAG confirm the role of local inflammation, as well as impairments in the structure of the extracellular matrix and its remodeling in the mechanisms of development of this pathology.
Heteroatom doping is a widely used method for the modification of the electronic and chemical properties of graphene.

A low-pressure chemical vapor deposition technique (CVD) is used here to grow pure, nitrogen-doped and phosphorous-doped few-layer graphene films from methane, acetonitrile and methane-phosphine mixture, respectively. The electronic structure of the films transferred onto SiO2/Si wafers by wet etching of copper substrates is studied by X-ray photoelectron spectroscopy (XPS) and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy using a synchrotron radiation source. Annealing in an ultra-high vacuum at ca. 773 K allows for the removal of impurities formed on the surface of films during the synthesis and transfer procedure and changes the chemical state of nitrogen in nitrogen-doped graphene.

Core level XPS spectra detect a low n-type doping of graphene film when nitrogen or phosphorous atoms are incorporated in the lattice. The electrical sheet resistance increases in the order: graphene < P-graphene < N-graphene. This tendency is related to the density of defects evaluated from the ratio of intensities of Raman peaks, valence band XPS and NEXAFS spectroscopy data.
BACKGROUND: The Masai giraffe (Giraffa camelopardalis tippelskirchi) is the largest-bodied giraffe and the world's tallest terrestrial animal. With its extreme size and height, the giraffe's unique anatomical and physiological adaptations have long been of interest to diverse research fields. Giraffes are also critical to ecosystems of sub-Saharan Africa, with their long neck serving as a conduit to food sources not shared by other herbivores. Although the genome of a Masai giraffe has been sequenced, the assembly was highly fragmented and suboptimal for genome analysis.

FINDINGS: Using SOAPdenovo2 and 170 Gbp of Illumina paired-end and mate-pair reads, we generated a 2.6-Gbp male Masai giraffe genome assembly, with a scaffold N50 of 3 Mbp. The incorporation of 114.6 Gbp of Chicago library sequencing data resulted in a HiRise SOAPdenovo + Chicago assembly with an N50 of 48 Mbp and containing 95% of expected genes according to BUSCO analysis. Using the Reference-Assisted Chromosome Assembly tool, we were able to order and orient scaffolds into 42 predicted chromosome fragments (PCFs). Using fluorescence in situ hybridization, we placed 153 cattle bacterial artificial chromosomes onto giraffe metaphase spreads to assess and assign the PCFs on 14 giraffe autosomes and the X chromosome resulting in the final assembly with an N50 of 177.94 Mbp. In this assembly, 21,621 protein-coding genes were identified using both de novo and homology-based predictions.

CONCLUSIONS: We have produced the first chromosome-scale genome assembly for a Giraffidae species. This assembly provides a valuable resource for the study of artiodactyl evolution and for understanding the molecular basis of the unique adaptive traits of giraffes. In addition, the assembly will provide a powerful resource to assist conservation efforts of Masai giraffe, whose population size has declined by 52% in recent years.
The aim of the research was to study the effect of depression, anxiety, and rumination scores on the balance of activity of the default mode network and attention networks revealed in the resting state EEG records.

Forty-five healthy volunteers (24 men aged from 18 to 25 years) participated in the resting state EEG recording. The participants filled in the Beck Depression Inventory-II (BDI II), Ruminative Responses Scale, and Eysenck Personality Profiler. The connectivity measures of resting state networks were calculated in EEG data. The networks were detected by the 'seed' method. The effects of depressive symptoms, anxiety, and rumination on the connectivity of the networks were analyzed by the regression method.

The depressive symptom scores and the rumination scores were correlated with the dominance of the default mode network over attention networks in the right temporal cortex. The depression scores and the anxiety scores were correlated with the dominance of attention networks over the default mode network in the anterior cingulate cortex. It could be suggested that rumination processes are specific for depressive symptoms and are reflected in the dominance of the default mode network in brain structures associated with the processing of emotional introspection. Common to depressive and anxious symptoms is a state of alertness, which is reflected in the dominance of attention networks in brain structures associated with decision-making.
A search is conducted for the electroweak pair production of a chargino and a neutralino $pp \rightarrow \tilde\chi^\pm_1 \tilde\chi^0_2$, where the chargino decays into the lightest neutralino and a $W$ boson, $\tilde\chi^\pm_1 \rightarrow \tilde\chi^0_1 W^{\pm}$, while the neutralino decays into the lightest neutralino and a Standard Model-like 125 GeV Higgs boson, $\tilde\chi^0_2 \rightarrow \tilde\chi^0_1 h$. Fully hadronic, semileptonic, diphoton, and multilepton (electrons, muons) final states with missing transverse momentum are considered in this search. Higgs bosons in the final state are identified by either two jets originating from bottom quarks ($h \rightarrow b\bar{b}$), two photons ($h \rightarrow \gamma\gamma$), or leptons from the decay modes $h \rightarrow WW$, $h \rightarrow ZZ$ or $h \rightarrow \tau \tau$. The analysis is based on 36.1 fb$^{-1}$ of $\sqrt{s} = 13$ TeV proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider. Observations are consistent with the Standard Model expectations, and 95% confidence-level limits of up to 680 GeV in $\tilde\chi^\pm_1/\tilde\chi^0_2$ mass are set in the context of a simplified supersymmetric model.
The results of a long-term study of the Campanula altaica phenotypic variation in the Western Siberian forest steppe (Novosibirsk) are described. Two ecotypes (subalpine and meadow) and three populations (Altai, Mountain Altai, and Tomsk) were assessed for the variation in phenological and several structural traits.

The PAleontological STatistics (PAST) tool was used for statistical data processing.

The adaptive changes in plant seasonal rhythms during their cultivation mainly appeared as a high lability of the flowering phase, whereas most phenological traits did not significantly differ at an intrapopulation level, reflecting an endogenous character of seasonal development. The intraspecific variation of structural traits is more pronounced: significant differences in the flowering shoot height, seed productivity per capsule, and several other characteristics are observed. The same traits of the accessions with different origins display different degrees and directions of changes. The least variable among the examined traits are the duration of vegetation, corolla diameter, and mass of 1000 seeds. High individual variation is a factor determining C. altaica as culturally sustainable species.
The article is devoted to the study of problems of finding the non-negative coefficient q(t) in the elliptic equation utt + a2Δu − q(t)u = f(x, t) (x = (x1, . . . , xn) ∈ Ω ⊂ Rn, t ∈ (0, T), 0 < T < +∞, Δ — operator Laplace on x1, . . . , xn). These problems contain the usual boundary conditions and additional condition ( spatial integral overdetermination condition or boundary integral overdetermination condition). The theorems of existence and uniqueness are proved