Hengzongshu/ArticleAgent huggingface dataset:
This study investigated the relationship between two subspecies of the Citellophilus tesquorum flea, C. t. altaicus and C. t. sungaris, which are vectors of the bacterium Yersinia pestis that causes human plague across the vast territories of the Palearctic. Adult fleas were collected from 16 localities and 11 populations in 2019 and 2020. Specimens were morphologically verified for subspecies status and analysed for mitochondrial cytochrome c oxidase subunit I (COI) DNA, nuclear ribosomal cluster internal transcribed spacer 1 (ITS1) and ITS2, and Wolbachia-infection status. Our results demonstrated a genetic difference between C. t. altaicus and C. t. sungaris. According to mitochondrial data, the genetic distance between clades of C. t. altaicus and C. t. sungaris was comparable with the species divergence of the genus Callopsylla, which is closely related to Citellophilus. All studied populations of C. t. altaicus were Wolbachia-infected, whereas all studied populations of C. t. sungaris were symbiont-free. Data for ITS1 and ITS2 had much lower phylogenetic signals than mitochondrial data; however, diagnostic substitutions for C. t. altaicus and C. t. sungaris delimitation were also revealed. Analysis of a hardly accessible report on cross experiments allowed us to conclude the partial postzygotic isolation between these subspecies. Taken together, the molecular-genetic, geographical, morphological, and reproductive isolation findings verified that C. t. altaicus and C. t. sungaris subspecies could be considered as different species.
New data on the litho- and biostratigraphy of the Jurassic/Cretaceous (J/K) boundary interval of the lower reaches of the Lena river, at the Cape Chekurovka and Cape Chucha, are presented. Volgian-Valanginian interval of the Chekurovka section is represented by Buolkalakh and Kigilyakh formations and corresponds to beds with Buchia fisheriana, beds with B. unschensis, beds with B. okensis and B. volgensis, beds with B. volgensis, beds with B. volgensis and B. tolmatschowi and beds with B. keyserlingi. Volgian-Valanginian interval of the Chucha section is represented by Chonoko, Khairgass and Kigilyakh formations and corresponds to beds with B. unschensis, beds with B. volgensis and B. okensis, beds with B. volgensis and B. tolmatschowi and beds with B. keyserlingi.
We report on Large-eddy simulations (LES) of flow around a short cylinder mounted in a narrow plane channel in a range of Reynolds numbers 1000, 2000, 3750 based on the bulk velocity of the flow and diameter of the cylinder supplemented with Particle image velocimetry (PIV) measurements for the highest considered Re.

First two cases appear to be steady, however, for R e =3750 the flow becomes unsteady with the wake dominated by periodic vortex shedding. In front of the cylinder typical horseshoe vortices are identified intensifying the skin friction and heat transfer on the wall, while in the near wake we observe a quasiperiodic low-frequency secondary motion in the form of a pair of counterrotating eddies developing in the transverse direction.

The Karman vortex street remains the dominant pattern, but further downstream from the cylinder the transport across the channel is associated with the secondary streamwise vortices, as also previously observed in slot jets. We observe their impact on heat transfer and skin friction on the wall of the channel.
The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites.The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites.The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms.It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.
Terahertz (THz) radiation is very promising for chemical and biological sensing. One of the ways to realize a THz sensor is exciting multipole localized surface plasmon resonances (LSPRs) on subwavelength corrugated metal disks.

In this paper, numerical modeling and analysis of LSPRs on a periodic array of such structures were made. At normal incidence of the incoming wave, only dipole resonances can be excited. An additional C-shaped resonator placed in the vicinity of the disk produces dark multipole modes (quadrupole, hexapole, octupole, and decapole ones) due to hybridization of these modes with the brigth dipole mode of the C resonator. Besides, multipole modes can be excited at oblique illumination of the structure.

With increase in the incident angle, the multipole resonances become stronger. The high Q-factor resonance modes observed for PEC disks are wider or disappeared in case of Drude gold permittivity.
Human α-lactalbumin (LA) has an important function in mammary cells, activates the caspases involving in apoptosis.LA complex interacts with DNA in tumor cells with histones and impaired the chromatin structure.There are no any data on how LA recognizes DNA and interact with histones and DNA of chromatin.The approach of stepwise increase in ligand complexity was used for estimation of the relative contribution of every DNA nucleotide unit to its total affinity for human LA.It was shown that the LA DNA-binding site minimal ligands are orthophosphate and all dNMPs and rNMPs (K d =(5.0-43)×10 -5 ).Maximal contribution to the total affinity was observed for three nucleotide units of all (pN) n with a significant decrease in the order 1>2>3, at n=4-6 it was remarkably lower and at n ≥ 6-7 all dependencies of -logK d upon n reached plateaus.Double-stranded (pN) n showed significantly lower affinity comparing with singlestranded ligands.The thermodynamic parameters characterizing the specific contribution of (pN) 1-6 every nucleotide link (ΔG o ) to their total affinity for LA were estimated.The spatial model of LA-DNA complex was calculated.LA protein sequence has homology with those of five histones (H1-H4) involved in the chromatin nucleus interactions between themselves and their complex with DNA.It is assumed that the homology may be the main reason for the interaction of LA with chromatin DNA, leading to a breakdown in its structure, as well as the proper binding of histones between themselves and with DNA.
Atka is a subduction-related volcanic island located in the central part of Aleutian Arc. The northeastern part of this island forms the Atka Volcanic Complex (AVC), which is built as a relict shield volcano of a circular shape overlain by several active and extinct volcanic vents of different ages. During the past few decades, two active volcanoes within AVC—Korovin and Kliuchef—demonstrated mostly phreatic eruptions and intensive fumarolic activity.

We have created the first tomographic model of the crust beneath AVC with the use of data of eight permanent stations of the Alaskan Volcanological Observatory operated in the time period from 2004 to 2017 that included arrival times of the P and S waves from local seismicity. Based on a series of checkerboard tests, we have demonstrated fair vertical and horizontal resolution of the model down to ~6 km depth.

Beneath the Korovin and Kliuchef volcanoes, we have revealed two isolated anomalies of high Vp/Vs with values exceeding 2, which represent separate magma chambers that are responsible for magmatic eruptions of these two volcanoes. In shallow layers down to 2–3 km deep, we observe an alternation of zones with low and high values of the Vp/Vs ratio, which are likely associated with the circulation of meteoric fluids in the uppermost crust. Moderately high Vp/Vs anomalies indicate zones of meteoric water penetration down to the ground. On the other hand, the very low values of Vp/Vs reaching 1.5 depict the areas where meteoric water reached the hot magma reservoir and transformed into steam. On the surface, these zones coincide with the distributions of fumaroles. The outflow of these steam currents from active vents of Korovin and Kliuchef led to episodic phreatic eruptions, sometimes synchronous.
The accurate simulation of additional interactions at the ATLAS experiment for the analysis of proton–proton collisions delivered by the Large Hadron Collider presents a significant challenge to the computing resources. During the LHC Run 2 (2015–2018), there were up to 70 inelastic interactions per bunch crossing, which need to be accounted for in Monte Carlo (MC) production.

In this document, a new method to account for these additional interactions in the simulation chain is described. Instead of sampling the inelastic interactions and adding their energy deposits to a hard-scatter interaction one-by-one, the inelastic interactions are presampled, independent of the hard scatter, and stored as combined events. Consequently, for each hard-scatter interaction, only one such presampled event needs to be added as part of the simulation chain.

For the Run 2 simulation chain, with an average of 35 interactions per bunch crossing, this new method provides a substantial reduction in MC production CPU needs of around 20%, while reproducing the properties of the reconstructed quantities relevant for physics analyses with good accuracy.
The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist - allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and mean), heart rate, blood flow, and tail blood volume. Stimulation of the TRPA1 ion channel by 2.5% AITC resulted in a diminishing rate of increase in blood pressure and a sharp increase in heart rate while recovering from anesthesia.
IgA anti-CD74 can be a promising marker for diagnosis, assessment of activity and prognosis for ankylosing spondylitis. The aim of the study was to determine the level of IgA anti-CD74 in patients with ankylosing spondylitis and to evaluate its relationships with ankylosing spondylitis activity and carriership of genetic alleles.

In 48 patients with a reliable diagnosis of ankylosing spondylitis, aged 18 to 69 years were measured the ASDAScrp, BASDAI, level of highly sensitive С-reactive protein, concentration of IgA anti-CD74. The polymorphisms of the genes interleukin (IL)-17A197 a/g, IL-17F7 histidine (His) / arginine (Arg), IL-17F11139 c/g, TNF-a-863, TNFα-308, TNFα-238, IL-1B-31, IL- 4-590, IL-6-174, IL-10-1082, IL-10-592, vascular endothelial growth factor (VEGF)-2578, VEGF-936, matrix metalloproteinase (MMP)2-1306, MMP3-5A6A, MMP9-1562, HLA-B27 were evaluated in their relationships with AS activity and IgA anti-CD74 levels.

The increase in anti-CD74 IgA level was found in 72.9% of patients with ankylosing spondylitis receiving inhibitors of TNF-a and NSAIDs and associated with clinical and laboratory indicators of ankylosing spondylitis activity and with carriage of the homozygous histidine allele IL-17F7 (his/his) detected in 93.8% of patients. Carriage of TNF-238 GG; TNF-863 CC; HLA-B27; TNF-308 GG; IL-4-590 CC; IL-6-174 CG; MMP9-1562 CC; MMP9-1562 CC; VEGF- 936 CC alleles was not associated with an increase in concentration of IgA anti-CD74. CRP demonstrated an association with IL-17A-197 AA (r=0.965) detected in 29.2% of patients with no correlation with the clinical ankylosing spondylitis activity in patients receiving treatment with iTNF-α and NSAIDs.
Residual stresses are common in metal structures, essentially influencing their mechanical behaviour. We consider a combined experimental/theoretical approach to residual stresses. The theoretical basis of analysis is provided by the recently developed F0-approach, operating with explicit relation between load-free and stress-free configurations. The titanium alloy Ti-6Al-4V is modelled with the multiplicative decomposition of the deformation gradient into the elastic and the plastic parts. Isotropic hyperelastic relations between stresses and elastic strains are assumed. The weak invariance of the material model allows for incorporation of residual stresses without additional numerical costs. In order to demonstrate the new experimental/theoretical approach to residual stresses, experimentally measured stresses are extrapolated from the surface inside the welded T-joint. The robustness of the stress extrapolation procedure is confirmed on synthetic experimental data.
Due to the growth of the number of scientific publications, the tasks related to scientific article processing become more actual. Such texts have a special structure, lexical and semantic content that should be taken into account while processing. Using information from knowledge bases can significantly improve the quality of text processing systems. This paper is dedicated to the entity linking task for scientific articles in Russian, where we consider scientific terms as entities. During our work, we annotated a corpus with scientific texts, where each term was linked with an entity from a knowledge base. Also, we implemented an algorithm for entity linking and evaluated it on the corpus. The algorithm consists of two stages: candidate generation for an input term and ranking this set of candidates to choose the best match. We used string matching of an input term and an entity in a knowledge base to generate a set of candidates. To rank the candidates and choose the most relevant entity for a term, information about the number of links to other entities within the knowledge base and to other sites is used. We analyzed the obtained results and proposed possible ways to improve the quality of the algorithm, for example, using information about the context and a knowledge base structure. The annotated corpus is publicly available and can be useful for other researchers.
MicroRNAs play a crucial role in eukaryotic gene regulation. For a long time, only little was known about microRNA-based gene regulatory mechanisms in polyploid animal genomes due to difficulties of polyploid genome assembly. However, in recent years, several polyploid genomes of fish, amphibian, and even invertebrate species have been sequenced and assembled.

Here we investigated several key microRNA-associated genes in the recently sequenced sterlet (Acipenser ruthenus) genome, whose lineage has undergone a whole genome duplication around 180 MYA. We show that two paralogs of drosha, dgcr8, xpo1, and xpo5 as well as most ago genes have been retained after the acipenserid-specific whole genome duplication, while ago1 and ago3 genes have lost one paralog. While most diploid vertebrates possess only a single copy of dicer1, we strikingly found four paralogs of this gene in the sterlet genome, derived from a tandem segmental duplication that occurred prior to the last whole genome duplication. ago1,3,4 and exportins1,5 look to be prone to additional segment duplications producing up to four-five paralog copies in ray-finned fishes. We demonstrate for the first time exon microsatellite amplification in the acipenserid drosha2 gene, resulting in a highly variable protein product, which may indicate sub- or neofunctionalization.

Paralogous copies of most microRNA metabolism genes exhibit different expression profiles in various tissues and remain functional despite the rediploidization process. Subfunctionalization of microRNA processing gene paralogs may be beneficial for different pathways of microRNA metabolism. Genetic variability of microRNA processing genes may represent a substrate for natural selection, and, by increasing genetic plasticity, could facilitate adaptations to changing environments.
We compared three formulations of the discrete dipole approximation (DDA) for simulation of light scattering by particles with refractive indices $m=10+10i$, $0.1+i$, and $1.6+0.01i$. These formulations include the filtered coupled dipoles (FCD), the lattice dispersion relation (LDR) and the radiative reaction correction.

We compared the number of iterations required for the convergence of the iterative solver (proportional to simulation time) and the accuracy of final results. Moreover, we analyzed the detailed structure of DDA errors and the spectrum of the DDA interaction matrix to understand the performance of the FCD.

We showed that the LDR performance for $m=10+10i$ is especially bad, while the FCD is a good option for all cases studied. In particular, this spectrum, obtained with the FCD for particles smaller than the wavelength, falls into the bounds, physically implied for the spectrum of the infinite-dimensional integral scattering operator, contrary to two other DDA formulations. Finally, such extreme refractive indices can now be routinely simulated using modern desktop computers using the publicly available ADDA code, which includes an efficient implementation of the FCD.
ABSTRACT Chromosome level assemblies are accumulating in various taxonomic groups including mosquitoes. However, even in the few reference-quality mosquito assemblies, a significant portion of the heterochromatic regions including telomeres remain unresolved. Here we produce a de novo assembly of the New World malaria mosquito, Anopheles albimanus by integrating Oxford Nanopore sequencing, Illumina, Hi-C and optical mapping. This 172.6 Mbps female assembly, which we call AalbS3, is obtained by scaffolding polished large contigs (contig N50=13.7 Mbps) into three chromosomes. All chromosome arms end with telomeric repeats, which is the first in mosquito assemblies and represents a significant step towards the completion of a genome assembly. These telomeres consist of tandem repeats of a novel 30-32 bp telomeric r epeat u nit (TRU) and are confirmed by analysing the termini of long reads and through both chromosomal in situ hybridization and a Bal31 sensitivity assay. The AalbS3 assembly included previously uncharacterized centromeric and rDNA clusters and more than doubled the content of transposable elements and other repetitive sequences. This telomere-to-telomere assembly, although still containing gaps, represents a significant step towards resolving biologically important but previously hidden genomic components. The comparison of different scaffolding methods will also inform future efforts to obtain reference-quality genomes for other mosquito species. 100-word Article Summary We report AalbS3, a telomere-to-telomere assembly of the Anopheles albimanus genome produced by integrating advancing technologies including Oxford Nanopore and Bionano optical mapping. AalbS3 features much of the difficult-to-assemble genomic ‘dark matters’ including previously missed transposons, centromeres and rDNA clusters. We describe novel telomeric repeats that are confirmed by analysis of long reads and by telomere hybridization assays. This reference-quality assembly represents a significant step towards completing the genomic puzzle pieces and informs efforts to improve the assembly of other mosquito species. Future research into the relationship between telomere and mosquito life span may have significant implications to disease control.
We present a fully relativistic investigation of the radiative recombination of a twisted electron with a bare heavy nucleus.

The twisted electron is described by the wave function which accounts for the interaction with the nucleus in all orders in $\ensuremath{\alpha}Z$. We use this wave function to derive the probability of the radiative recombination with a single ion being shifted from the twisted electron propagation direction. This probability is utilized for the consideration of a more realistic experimental scenario where the target is infinitely wide (macroscopic). The situation when the incident electron is a coherent superposition of two vortex states is considered as well. For the nonrelativistic case we present analytical expressions which support our numerical calculations.

We study in details the influence of the electron twistedness on the polarization and angular distribution of the emitted photon.
The first annotated checklist of the long-horned Orthoptera (Ensifera) of Tuva and adjacent territories is presented. This list is based on numerous published and unpublished data.

A total of 22 species belonging to 2 families, namely Tettigoniidae and Gryllidae, are known as occurring in Tuva. Six species are recorded from the region for the first time, namely Tettigonia cantans (Fuessly), Platycleis albopunctata (Goeze), Platycleis affinis Fieber (also new for the Asian part of Russia), Roeseliana fedtschenkoi (Saussure), Poecilimon intermedius (Fieber), Acheta domesticus (Linnaeus) (synanthrope). Montana tomini (Pylnov) is also mentioned for the southern part of Krasnoyarsk Region for the first time.

Six species are known from the adjacent areas and listed as probably occurring in the region.
We measure the branching fractions and $CP$ asymmetries for the decays $B^{0}\to \bar{D}^{0}\pi^{0}$ and $B^{+}\to \bar{D}^{0}\pi^{+}$, using a data sample of $772\times 10^{6}$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^{+}e^{-}$ collider. The branching fractions obtained and direct $CP$ asymmetries are $\mathcal{B}(B^{0}\to \bar{D}^{0}\pi^{0}) = [2.70 \pm 0.06~ \text{(stat.)} \pm 0.10~ \text{(syst.)}] \times 10^{-4}$, $\mathcal{B}(B^{+}\to \bar{D}^{0}\pi^{+}) = [4.53 \pm 0.02~ \text{(stat.)} \pm 0.15~ \text{(syst.)}] \times 10^{-3}$, $ {\cal A}_{CP}(B^{0}\to \bar{D}^{0}\pi^{0}) = [+0.42 \pm 2.05~ \text{(stat.)} \pm 1.22~ \text{(syst.)}]\%$, and $ {\cal A}_{CP}(B^{+}\to \bar{D}^{0}\pi^{+}) = [+0.19 \pm 0.36~ \text{(stat.)} \pm 0.57~ \text{(syst.)}]\%$. The measurements of $\mathcal{B}$ are the most precise to date and are in good agreement with previous results, as is the measurement of ${\cal A}_{CP}(B^{+}\to \bar{D}^{0}\pi^{+})$. The measurement of ${\cal A}_{CP}$ for $B^{0}\to \bar{D}^{0}\pi^{0}$ is the first for this mode, and the value is consistent with Standard Model expectations.
Проведены исследования межзонной фотопроводимости и фотолюминесценции в узкозонных волноводных структурах с квантовыми ямами на основе HgCdTe, дизайн которых предназначен для получения длинноволнового стимулированного излучения в условиях оптической накачки.

В структурах n-типа времена релаксации фотопроводимости достигают нескольких микросекунд, что позволяет наблюдать стимулированное излучение на длине волны 10.2 мкм с низкой пороговой интенсивностью накачки &#126;100 Вт/см 2 при 20 K.

В структурах p-типа, полученных отжигом для увеличения концентрации вакансий ртути, из-за резкого уменьшения времени жизни относительно безызлучательной рекомбинации Шокли-Рида-Холла не удается наблюдать даже спонтанное излучение из квантовых ям.
The dipole form of the “Abelian” part of the massless quark contribution to the BFKL kernel is found in the coordinate representation by direct transfer from the momentum representation where the contribution was calculated before. It coincides with the corresponding part of the quark contribution to the dipole kernel calculated recently by Balitsky and is conformal invariant.