Hengzongshu/ArticleAgent huggingface dataset:
HIV-1 integrase (IN) catalyzes integration of a DNA copy of the viral genome into the host genome. In contrast to canonical proteases (trypsin, chymotrypsin and proteinase K)

IgGs and IgMs isolated from HIV-infected patients by affinity chromatography on immobilized IN specifically hydrolyzed only IN but not many other tested intact globular proteins. The sites of IN cleavage determined by MALDI mass spectrometry were localized mainly within seven known immunodominant regions of IN. Thin layer chromatography analysis has shown that the abzymes (Abzs) could also cleave 17 to 22-mer oligopeptides (OPs) corresponding to the immunodominant regions of IN sequence with a much higher rate than non-specific long peptides or three- and tetrapeptides of various sequence.

Therefore, a prolonged incubation of IN with AIDS IgGs and IgMs having high catalytic activity usually produces many OPs of different length. Since anti-IN IgGs and IgMs can efficiently hydrolyze IN, a positive role of the Abzs in counteracting the infection is possible.
The article deals with the representation of the concept of money in the feature film Elena by Andrey Zvyagintsev.

Money is first of all a plot-forming element because this is the reason behind the conflict between the main characters, which is shown in the film. At the visual level, the concept is represented explicitly by constant demonstration of money, and implicitly, with the help of objects reflecting the level of people’s welfare. We also found out several attributes of this concept at the verbal level, in the discourse of the characters.

There is a striking contrast between the ‘world of the rich’, whose main representative is Vladimir, and the ‘world of the poor’ where Elena’s son’s family live. The protagonist unites these two worlds. Some of these attributes are connected with the functioning of money, its use in the daily life, and legal financial aspects. Vladimir’s discourse contains verbal markers reflecting his idea of money as a symbol of work, responsibility for one’s own life and their family’s welfare, a symbol of maturity and independence. The analysis of the discourse of Elena and her relatives revealed completely different realizations of the concept, demonstrating that in their worldview money represents help and support which people are obliged to give to the ones who are in difficult situations. Less frequent concept attributes are meaning of life and freedom.
Timed transition systems are a widely studied model for real-time systems. The intention of the paper is to show how several categorical (open maps, path-bisimilarity and coalgebraic) approaches to an abstract characterization of bisimulation relate to each other and to the numerous suggested behavioral equivalences of linear time -- branching time spectrum, in the setting of timed transition systems.
Experimental results of the investigation of self-healing properties of terahertz Bessel beams with orbital angular momentum (OAM) with topological charges of l=3 and l=4 in free space after passing through a dispersive medium are presented.
Some features of the physics of radiation-dominated shock waves are discussed with emphasis on the peculiarities which are important for correct numerical modeling of shock breakouts in supernova.

With account of those peculiarities, a number of models for different supernova types is constructed based on multigroup radiation transfer coupled to hydrodynamics. We describe the implementation of a new algorithm RADA, designed for modeling photon transfer at extremely-relativistic motions of matter, into our older code STELLA.

The results of numerical simulations of light curves, and continuum spectra are presented. The influence of effects of photon scattering on electrons, of thermalization depth and of special relativity in transfer equation is considered. Some cases are demonstrated, when the appearance of hard X-ray emission is possible at the shock breakout. The necessary refinements in numerical algorithms for radiative transfer and hydrodynamics are pointed out. Prospects for using the results of numerical simulation to analyze and interpret available and future data from space observatories are discussed.
The Gaching high-sulfidation (HS) epithermal Au–Ag deposits, part of the Maletoyvayam ore field, which is located in the volcanic belts of the Kamchatka Peninsula (Russia). The main ore components are native gold, tellurides, selenides, and sulphoselenotellurides of Au and oxidation products of Au-tellurides. This study examines the different types of native gold in this ore deposit and the mechanisms and sequential transformation of calaverite (AuTe2) into mustard gold. The primary high fineness gold (964‰–978‰) intergrown with maletoyvayamite Au3Te6Se4 and other unnamed phases (AuSe, Au(Te,Se)) differ from the secondary (mustard) gold in terms of fineness (1000‰) and texture. Primary gold is homogeneous, whereas mustard is spongy. Two types of mustard gold were identified: (a) Mixtures of Fe-Sb(Te,Se,S) oxides and fine gold particles, which formed during the hypogenic transformation stage of calaverite due to the impact of hydrothermal fluids, and (b) spotted and colloform gold consisting of aggregates of gold particles in a goethite/hydrogoethite matrix. This formed during the hypergenic transformation stage. Selenides and sulphoselenotellurides of gold did not undergo oxidation. Pseudomorphic replacement of calaverite by Au-Sb(Te,Se,S,As) oxides was also observed.
In this paper an algorithm for constructing ENO schemes on unstructured grids for Navier-Stokes equations supplemented by the equations for the concentrations of chemicals is considered.

A second order accuracy scheme, based on the linear reconstruction of a function in cells, is presented.

The mathematical model was verified on the task of analyzing the gas-dynamic parameters of the gross reaction of ethane pyrolysis.
Effects of light millicharged dark matter particles on primordial nucleosynthesis are considered.

It is shown that if the mass of such particles is much smaller than the electron mass, they lead to strong overproduction of Helium-4. An agreement with observations can be achieved by non-vanishing lepton asymmetry.

Baryon-to-photon ratio at BBN and neutrino- to-photon ratio both at BBN and at recombination are noticeably different as compared to the standard cosmological model. The latter ratio and possible lepton asymmetry could be checked by Planck. For higher mass of new particles the effect is much less pronounced and may even have opposite sign.
Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out-both in humans and in animal models-confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD.

The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum.

Pathogenic microflora of the oral cavity, through mechanisms of immunomodulation, can affect the motility of the gallbladder and the expression of mucin genes
Learning and memory are among higher-order cognitive functions that are based on numerous molecular processes including changes in the expression of genes.

To identify genes associated with learning and memory formation, here, we used the RNA-seq (high-throughput mRNA sequencing) technology to compare hippocampal transcriptomes between mice with high and low Morris water maze (MWM) cognitive performance. We identified 88 differentially expressed genes (DEGs) and 24 differentially alternatively spliced transcripts between the high- and low-MWM-performance mice.

Although the sets of DEGs and differentially alternatively spliced transcripts did not overlap, both were found to be enriched with genes related to the same type of biological processes: trans-synaptic signaling, cognition, and glutamatergic transmission. These findings were supported by the results of weighted-gene co-expression network analysis (WGCNA) revealing the enrichment of MWM-cognitive-performance-correlating gene modules with very similar Gene Ontology terms. High-MWM-performance mice manifested mostly higher expression of the genes associated with glutamatergic transmission and long-term potentiation implementation, which are processes necessary for memory acquisition and consolidation. In this set, there were genes participating in the regulation of trans-synaptic signaling, primarily AMPA receptor signaling ( Nrn1 , Nptx1 , Homer3 , Prkce , Napa , Camk2b , Syt7 , and Nrgn ) and calcium turnover ( Hpca , Caln1 , Orai2 , Cpne4 , and Cpne9 ). In high-MWM-performance mice, we also demonstrated significant upregulation of the 'flip' splice variant of Gria1 and Gria2 transcripts encoding subunits of AMPA receptor. Altogether, our data helped to identify specific genes in the hippocampus that are associated with learning and long-term memory. We hypothesized that the differences in MWM cognitive performance between the mouse groups are linked with increased long-term potentiation, which is mainly mediated by increased glutamatergic transmission, primarily AMPA receptor signaling.
A computational method, to predict the pKa values of the ionizable residues Asp, Glu, His, Tyr, and Lys of proteins, is presented here.

Calculation of the electrostatic free-energy of the proteins is based on an efficient version of a continuum dielectric electrostatic model. The conformational flexibility of the protein is taken into account by carrying out molecular dynamics simulations of 10 ns in implicit water. The accuracy of the proposed method of calculation of pKa values is estimated from a test set of experimental pKa data for 297 ionizable residues from 34 proteins.

The pKa-prediction test shows that, on average, 57, 86, and 95% of all predictions have an error lower than 0.5, 1.0, and 1.5 pKa units, respectively. This work contributes to our general understanding of the importance of protein flexibility for an accurate computation of pKa, providing critical insight about the significance of the multiple neutral states of acid and histidine residues for pKa-prediction, and may spur significant progress in our effort to develop a fast and accurate electrostatic-based method for pKa-predictions of proteins as a function of pH.
Our aim was to study changes in the serum proteomic profile in coronary atherosclerosis.The study involved two groups of patients: 1) men with coronary heart disease and coronary atherosclerosis (n = 15); 2) control (n = 15): men without coronary heart disease.

The object of this study was blood serum. Separation of proteins for the investigation of differences in serum protein components was performed by two-dimensional electrophoresis. Identification of protein fractions was carried out using peptide mass maps by the matrix-assisted laser desorption ionization method.In blood serum samples from patients with coronary atherosclerosis, protein separation in two-dimensional gels with mass-spectrometric identification revealed an increase of some proteins: hemopexin, transthyretin (monomeric form), retinol-binding protein 4, and components of the complement system: C3 (chain B) and C9. There was a decrease of some proteins: kininogen, zinc finger protein 133, and B-cell CLL/lymphoma 6 member B protein. Comparisons between the experimental and control group were carried out in protein fractions where the protein amount differed more than 1.5-fold (p < 0.05).

Proteome profiling of serum revealed a change in the content of kininogen, hemopexin, transthyretin, retinol-binding protein, and proteins of the complement system (C9, and C3) in coronary atherosclerosis. The contribution to the differential expression of a protein was often made by isoforms of the protein, particularly transthyretin. The change in the concentrations of functionally interacting proteins, such as transthyretin and retinol-binding protein, were noted.
FRAXopathies are caused by the expansion of the CGG repeat in the 5′UTR of the FMR1 gene, which encodes the protein responsible for the synthesis of FMRP. This mutation leads to dramatic changes in FMRP expression at both the mRNA and protein levels. Evidence is emerging that changes in FMR1 mRNA expression can lead to the dysregulation of the miRNAs that target its 3′UTR. In the present work, B-lymphocyte cell lines obtained from patients with FRAXopathies were used, and a wide variety of FMR1 gene activities were observed, allowing the identification of the relationships between FMR1 dysregulation and miRNA activity. We studied the expression levels of eight miRNAs that target the FMR1 gene. To prove the interaction of the studied miRNAs with FMR1, a plasmid was constructed that possesses three primary structures: the miRNA gene, with expression driven by an inducible promoter; a constitutively expressed FusionRed reporter; and an eGFP reporter followed by the 3′UTR of the FMR1 gene. We evaluated changes in miRNA expression in response to alterations in FMR1 gene activity in a model cell line as well as interactions with some miRNAs with the FMR1 3′UTR.
The paper includes a brief overview of previous researches on the stabilization of MHD instabilities, study of micro-instabilities, and demonstration a tangible increase of the electron temperature with application of auxiliary ECR heating. A review of the results of recent researches related to application of microwave radiation for plasma generation, and plasma heating in the GDT device is presented. The paper summarizes also recent results of researches that oriented on study of expander physics.
The outflow of supercritical coolant with different initial parameters and its impact on the barrier have been numerically simulated. Spatial and axial distributions of pressure and steam quality are presented. The force acting on the barrier at different parameters of the outflow has been calculated.
We study a multi-country trade model with two types of countries (big and small ones). The model generalizes the case of two countries analyzed in [Bykadorov I., Molchanov P., Kokovin S. (2015), "Elusive Pro-competitive Effects and Harm from Gradual Trade Liberalization, "Preprint 295, Sobolev Institute of Mathematics SB RAS, Novosibirsk, February 2015] and wonder whether there could be harm from trade.

Monopolistic competition, iceberg type trade costs and variable elasticity of substitution (VES) are among the model assumptions.

The effects of trade liberalization on price, production and welfare are analyzed, in cases of free trade and autarky.
In the Devonian the Minusa Intermountain Trough (Basin) of Siberia represented a rift structure that was filled with rocks which now occur as strata-like bodies interpreted to be of volcanic origin.

The character of the mafic rocks including their upper contacts and geochronological dating, using Rb/Sr, 40 Ar/ 39 Ar, and U/Pb methods, suggests their sill or subvolcanic nature.Porphyry and dolerite sills and basalt formed later (385-405 Mya) than felsic and andesitic volcanic rocks (402-448 Mya).

Because these bodies were earlier considered as volcanic flows, it is important to revise the geological succession of the Devonian formations dominated by mafic igneous rocks.
Ce 0.5 Zr 0.5 O 2 mixed oxides were prepared in a flow reactor in supercritical isopropanol with acetylacetone as a complexing agent. Variation of the nature of the Zr salt and the temperature of synthesis affected the phase composition, morphology and specific surface area of oxides. X-ray diffraction and Raman spectroscopy studies revealed formation of metastable t” and t’ phases. Oxides are comprised of agglomerates with sizes depending on the synthesis parameters. Loading NiO decreases the specific surface area without affecting X-ray particle sizes of supports. Such sintering was the most pronounced for a support with the highest specific surface area, which resulted in the lowest surface content of Ni as estimated by X-ray photoelectron spectroscopy and in the formation of flattened NiO particles partially embedded into the support. The catalytic activity and stability of these samples in the dry reforming of methane were determined by the surface concentration of Ni and the morphology of its particle controlled by the metal-support interaction, which also depends on the type of catalyst pretreatment. Samples based on ceria-zirconia oxides prepared under these conditions provide a higher specific catalytic activity as compared with the traditional Pechini route, which makes them promising for the practical application.
The study is focused on the performance of machine-learning methods applied to improve the velocity field predictions in canonical turbulent flows by the Reynolds-averaged Navier–Stokes (RANS) equation models. A key issue here is to approximate the unknown term of the Reynolds stress (RS) tensor needed to close the RANS equations. A turbulent channel flow with the curved backward-facing step on the bottom has the high-fidelity LES data set. It is chosen as the test case to examine possibilities of GEP (gene expression programming) of formulating the enhanced RANS approximations. Such a symbolic regression technique allows us to get the new explicit expressions for the RS anisotropy tensor. Results obtained by the new model produced using GEP are compared with those from the LES data (serving as the target benchmark solution during the machine-learning algorithm training) and from the conventional RANS model with the linear gradient Boussinesq hypothesis for the Reynolds stress tensor.
For families of all theories of arbitrary given languages we describe ranks and degrees. In particular, we characterize (non-)totally transcendental families. We apply these characterizations for the families of all theories of given languages, with models of given finite or infinite cardinality.
Such results are in line with the lack of arousal model in ADHD children

In the current study, we aimed to investigate the associations between the natural variability in hyperactivity and inattention scores, as well as their combination with EEG oscillatory responses in the Stop-Signal task in a sample of healthy children. During performance, the Stop-Signal task EEGs were recorded in 94 Caucasian children (40 girls) from 7 to 10 years.

Hyperactivity/inattention and inattention scores positively correlated with RT variability. Hyperactivity/inattention and inattention scores negatively correlated with an increase in beta spectral power in the first 200 ms after presentation of the Go stimulus. Such results are in line with the lack of arousal model in ADHD children and can be associated with less sensory arousal in the early stages of perception in children with symptoms of inattention. The subsequent greater increase in theta rhythm at about 300 ms after presentation of the Go stimulus in children with higher inattention scores may be associated with increased attention processes and compensation for insufficient vigilance in the early stages of perception.
The study examines revolutionary waves – the process of spreading protest activity from one society to another. The author reveals the specifics and analyzes the nature of relations within the 'red wave' in post-war Asia in the 40s – 70s of the twentieth century.

The paper explains the structural, ideological and organizational relationship between these revolutions (uprising, partisan wars) using the world system analysis, demographic and structural theory, the theory of military revolutions, and the neo-Marxist model of B. Moore.

These approaches helped to explain the authoritarian, dirigiste an egalitarian Asian 'wave', and also highlighted two ideologically and organizationally separate 'waves'.
Using the path-integral technique we calculate the mutual information for the fiber optical channel modelled by the nonlinear Schrödinger equation with additive Gaussian noise. At large signal-to-noise ratio (SNR) we present the mutual information through the path-integral which is convenient for the perturbative expansion both in nonlinearity and dispersion. In the leading order in 1/SNR we demonstrate that the mutual information is determined through the averaged logarithm of the normalization factor Λ of the conditional probability density function P[Y|X]. In the limit of small noise and small nonlinearity we derive analytically the first nonzero nonlinear correction to the mutual information for the channel. For the arbitrary nonlinearity we restrict the mutual information by the low bound obtained from the Jensen's inequality and analyze the bound for the case of large dispersion.
A series of 5%Ni-CexZr1−xO2 (x = 0.3, 0.5, 0.7) catalysts has been prepared via one-pot solvothermal continuous synthesis in supercritical isopropanol and incipient wetness impregnation of CexZr1−xO2 obtained by the same route.

The textural, structural, red-ox, and catalytic properties in methane dry reforming (MDR) of Ni-modified Ce-Zr oxides synthesized by two routes have been compared. It was shown by XRD, TEM, and Raman spectroscopy that the method of Ni introduction does not affect the phase composition of the catalysts, but determines the dispersion of NiO.

Despite a high dispersion of NiO and near-uniform distribution of Ni within Ce-Zr particles observed for the one-pot catalysts, they have shown a lower activity and stability in MDR as compared with impregnated ones. This is a result of a low Ni concentration in the surface layer due to segregation of Ce and decoration of nickel nanoparticles with support species.
A bstract A measurement of the inclusive Z → ττ cross-section in pp collisions at $ \sqrt{s}=7\,\mathrm{TeV} $ is presented based on a dataset of 1 . 0 fb −1 collected by the LHCb detector. Candidates for Z → τ τ decays are identified through reconstructed final states with two muons, a muon and an electron, a muon and a hadron, or an electron and a hadron. The production cross-section for Z bosons, with invariant mass between 60 and 120 GeV /c 2 , which decay to τ leptons with transverse momenta greater than 20 GeV /c and pseudorapidities between 2 . 0 and 4 . 5, is measured to be σ pp →Z→ ττ = 71 . 4 ± 3 . 5 ± 2 . 8 ± 2 . 5 pb; the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the integrated luminosity. The ratio of the cross-sections for Z → τ τ to Z → μμ is determined to be 0 . 93 ± 0 . 09, where the uncertainty is the combination of statistical, systematic, and luminosity uncertainties of the two measurements.
Understanding the genetic architecture of drought tolerance is of great importance for overcoming the negative impact of drought on wheat yield. Earlier, we discovered the critical role of chromosome 2A for the drought-tolerant status of wheat spring cultivar Saratovskaya 29. A set of 92 single-chromosome recombinant double haploid (SCRDH) lines were obtained in the genetic background of Saratovskaya 29. The lines carry fragments of chromosome 2A from the drought-sensitive cultivar Yanetzkis Probat. The SCRDH lines were used to identify regions on chromosome 2A associated with the manifestation of physiological and agronomical traits under distinct water supply, and to identify candidate genes that may be associated with adaptive gene networks in wheat. Genotyping was done with Illumina Infinium 15k wheat array using 590 SNP markers with 146 markers being polymorphic. In four identified regions of chromosome 2A, 53 out of 58 QTLs associated with physiological and agronomic traits under contrasting water supply were mapped. Thirty-nine candidate genes were identified, of which 18 were transcription factors. The region 73.8-78.1 cM included the largest number of QTLs and candidate genes. The variation in SNPs associated with agronomical and physiological traits revealed among the SCRDH lines may provide useful information for drought related marker-assisted breeding.