Hengzongshu/ArticleAgent huggingface dataset:
Aim . To study associations of cardiovascular diseases and type 2 diabetes (T2D) with ophthalmic diseases in a population sample of men and women from middle to old age (Novosibirsk). Material and methods . The population cohort was initially studied in 2003-2005 (n=9360, 45-69 years old, Novosibirsk, the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) project). At the second survey (2015-2017) in a random subsample (n=1011), the following ophthalmic diseases were identified: hypertensive retinopathy (HR), diabetic retinopathy (DR), cataract, glaucoma, age-related macular degeneration (AMD), optic disc abnormalities, etc. Results . The prevalence of HR signs in persons with and without hypertension (HTN) was 81 and 46%, respectively (p<0,001). This association persisted regardless of other factors (odds ratio, 2,27 (95% confidence interval: 1,78-4,17). The prevalence of AMD, cataract and DR increased in HTN, but associations were largely explained by metabolic factors in multivariate models. People with T2D more often than without T2D had signs of DR (9,3 vs 0,4%, p<0,001), AMD (22 vs 17%, p=0,042) and glaucoma (14 vs 7%, p=0,001). Associations of T2D with DR and glaucoma persisted regardless of other factors. Individuals with carotid atherosclerosis (CA) were 1,6 times more likely to have HR than those without CA when adjusted for sex, age, and smoking (p=0,013). Conclusion . In the surveyed population sample of mainly elderly people, a number of associations between cardiometabolic and common ophthalmic diseases were revealed. The identified comorbidities may have important therapeutic and prophylactic applications in an aging population.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Aeribacillus pallidus strain 8m3, a thermophilic aerobic oil-oxidizing bacterium isolated from production water from the Dagang high-temperature oil field, China

The draft genome sequence is presented here

The genome is annotated to provide insights into the genomic and phenotypic diversity of the genus Aeribacillus
A parallel server system with n identical servers is considered. The service time distribution has a finite mean 1 / μ, but otherwise is arbitrary. Arriving customers are routed to one of the servers immediately upon arrival. The join-idle-queue routeing algorithm is studied, under which an arriving customer is sent to an idle server, if such is available, and to a randomly uniformly chosen server, otherwise. We consider the asymptotic regime where n → ∞ and the customer input flow rate is λ n . Under the condition λ / μ < ½, we prove that, as n → ∞, the sequence of (appropriately scaled) stationary distributions concentrates at the natural equilibrium point, with the fraction of occupied servers being constant at λ / μ. In particular, this implies that the steady-state probability of an arriving customer waiting for service vanishes.
In the mathematical model of melting of a tungsten plate exposed to a pulsed electron beam, the calculation of the current distribution in the medium is added. The model takes into account the heterogeneity of the resistivity.

This enables modeling of non-uniform heated material. The current is expected to spread into the depth due to the increased resistance of the heated part. Changing the thickness of the tungsten plate, one can increase the current density in the melt.

The calculation results for parameters corresponding to those used on the BETA facility at BINP SB RAS show that no current concentration occur. The Ampere force is not large enough for the rotation observed in the experiments.
Small supernumerary marker chromosomes (sSMC) and B-chromosomes represent a heterogeneous collection of chromosomes added to the typical karyotype, and which are both small in size. They may consist of heterochromatic and/or euchromatic material. Also a predominance of maternal transmission was reported for both groups. Even though sSMC and B-chromosomes show some similarity it is still an open question if B-chromosomes are present among the heterogeneous group of sSMC. According to current theories, sSMC would need drive, drift or beneficial effects to increase in frequency in order to become B chromosome. However, up to now no B-chromosomes were described in human. Here we provide first evidence and discuss, that among sSMC B-chromosomes might be hidden. We present two potential candidates which may already be, or may in future evolve into B chromosomes in human: (i) sSMC cases where the marker is stainable only by DNA derived from itself; and (ii) acrocentric-derived inverted duplication sSMC without associated clinical phenotype. Here we report on the second sSMC stainable exclusively by its own DNA and show that for acrocentric derived sSMC 3.9× more are familial cases than reported for other sSMC. The majority of sSMC are not to be considered as B-chromosomes. Nonetheless, a minority of sSMC show similarities to B-chromosomes. Further studies are necessary to come to final conclusions for that problem.
In the paper, an experimental investigation of the turbulent structure of bubbly free and impinging jets was carried out by means of PIV and PFBI techniques.

PIV was applied to measure velocity distributions and turbulent characteristics in the continuous phase, while the PFBI approach was applied to visualize bubbles in the flow and evaluate their sizes. The flow was studied at the Reynolds number of 12,500 and three void fractions β = 0, 1 and 2%. The mean air bubble diameter was estimated to be roughly 0.8 mm for all β.

It was revealed that, in the free jet, the air bubbles reduce the jet core size by more than 30% at the distance of a half of the nozzle diameter. In the two-phase jet, the radial velocity fluctuations rise faster in the mixing layer in the initial jet region between the nozzle edge and the downstream position of 40% of the nozzle diameter but further downstream they are suppressed about two times by the bubbles. In the impinging jet, the bubbles produce a high peak of the radial component of turbulent fluctuations near the wall at the distance of 70% of the nozzle diameter from the jet axis.
A solid-state system combining a stable spin degree of freedom with an efficient optical interface is highly desirable as an element for integrated quantum optical and quantum information systems. We demonstrate a bright color center in diamond with excellent optical properties and controllable electronic spin states. Specifically, we carry out detailed optical spectroscopy of a Germanium Vacancy (GeV) color center demonstrating optical spectral stability. Using an external magnetic field to lift the electronic spin degeneracy, we explore the spin degree of freedom as a controllable qubit. Spin polarization is achieved using optical pumping, and a spin relaxation time in excess of 20 $\mu$s is demonstrated. Optically detected magnetic resonance (ODMR) is observed in the presence of a resonant microwave field. ODMR is used as a probe to measure the Autler-Townes effect in a microwave-optical double resonance experiment. Superposition spin states were prepared using coherent population trapping, and a pure dephasing time of about 19 ns was observed. Prospects for realizing coherent quantum registers based on optically controlled GeV centers are discussed.
Simulations of proton-driven plasma wakefield accelerators have demonstrated substantially higher accelerating gradients compared to conventional accelerators and the viability of accelerating electrons to the energy frontier in a single plasma stage. However, due to the strong intrinsic transverse fields varying both radially and in time, the witness beam quality is still far from suitable for practical application in future colliders. Here we demonstrate efficient acceleration of electrons in proton-driven wakefields in a hollow plasma channel. In this regime, the witness bunch is positioned in the region with a strong accelerating field, free from plasma electrons and ions. We show that the electron beam carrying the charge of about 10% of 1 TeV proton driver charge can be accelerated to 0.6 TeV with preserved normalized emittance in a single channel of 700 m. This high quality and high charge beam may pave the way for the development of future plasma-based energy frontier colliders.
In the article on the basis of the cluster, 20 oil and gas regions of Russia are allocated for which the level of pipeline provision is calculated. The group with a low level of transport security included mainly the regions of Eastern Siberia and the Far East. On the example of the ESPO and the “Power of Siberia” it is shown that the construction of pipelines favorably affects the socio-economic development of regions along the routes.
Archaeological and geomorphological studies at several sites near the village of Anzhevka contribute to the understanding of the cultural and chronological situation in the region during the Quaternary. They are especially relevant to intermediate regions such as the Kansk-Rybinsk Basin situated between the Baikal, Angara, and Yenisei drainages. Rescue excavations near Kansk on the right bank of the Kan River in 2015 yielded numerous fi nds relating to the Quaternary and the origin of modern topography of that basin. Excavated sites near Anzhevka include Nefteprovod-1 and -2 and Ryabchikov Klyuch-1, spanning the period from the Upper Paleolithic to recent centuries and including five geomorphological segments with different types of Quaternary deposits. The main landscape type at Ryabchikov Klyuch-1 is sharply ridged segmented, and that at Nefteprovod-1 and -2 is defined by structural denudation. It occupies the right edge of the Kan Valley, raised and divided into neotectonic blocks differing in elevation. The nature of the cuts is determined by geomorphological segmentation: the Quaternary stratum begins from the alluvial pack, and in certain areas between the pre-Quaternary sediments and the subaerial cover the alluvium is absent. Cultural layers are deposited in the upper pack, represented by the subaerial cover differing in various areas due to local alluvial erosion and aeolian deflation. Studies show the peculiar nature of geomorphology and sediments of the area, different from those at Strizhovaya Gora located 3.5 km downstream the Kan River.
Territory of Mongolia is situated in the center of Asia, a crossroad of the potential migration routes, that connect different Eurasian macroregions. Here an example of earliest appearance and longterm existence of small blade and microblade production has been found. Beyond that, the industries, that appeared within limited area of the Middle Selenga Basin in the late MIS3 — early MIS2, contained the earliest for Northern and Central Asia geometric and non-geometric microliths. They have been found in the sediments of Kharganyn Gol 5 and Tolbor-4, — 16 and –21. They end up in LGM — post- LGM which cause depopulation in the region and following changes in the human groups, occupying this territory.

An understanding of the character, causes and specifics of such early appearance of the microblade and bladelet production, and especially geometric microliths, impose the arrangement and definition of the terminology, associated with microlithic assemblages in Asia. This is due to the fact that in the archaeological definitions of both processes and the desired forms of artifacts associated with the production and use of microliths, there are significant discrepancies that complicate the understanding of the described phenomena.

The article provides an overview of the research terminology of microlithization processes, and also determines the position of the microlithic complexes of Mongolia in the Upper Paleolithic system of the eastern part of Asia.
An infinite sequence x 1 x 2 … of letters from some alphabet { 0 , 1 , … , b − 1 } , b ≥ 2 , is called k-distributed ( k ≥ 1 ) if any k-letter block of successive digits appears with the frequency b − k in the long run. The sequence is called normal (or ∞-distributed) if it is k-distributed for any k ≥ 1 . We describe two classes of low-entropy processes that with probability 1 generate either k-distributed sequences or ∞-distributed sequences. Then, we show how those processes can be used for building random number generators whose outputs are either k-distributed or ∞-distributed. Thus, these generators have statistical properties that are mathematically proven.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by mutation in the HTT gene encoding HTT protein. The mutant protein leads to the neuronal death through dysregulation of multiple cellular processes. HD human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the disease study.

iPSC line from HD patient with 47 CAG repeats in HTT was generated from blood mononuclear cells by non-integrating episomal vectors. The iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype and displayed in vitro differentiation to the three germ layers.

Resource table.Unique stem cell lines identifierICGi007-AAlternative name(s) of stem cell line47Q-3LfInstitutionFederal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, RussiaContact information of distributorElena V. Grigor'eva[email protected]Type of cell linesiPSCOriginHumanAdditional origin infoAge: 27Sex: FEthnicity: CaucasianCell SourcePeripheral blood mononuclear cellsClonalityClonalMethod of reprogrammingTransgene free episomal plasmid vectorsGenetic ModificationYESType of ModificationHereditaryAssociated diseaseHuntington's diseaseGene/locusHTT/4p16.3Method of modificationN/AName of transgene or resistanceN/AInducible/constitutive systemN/ADate archived/stock dateDecember 2017Cell line repository/bankhttps://hpscreg.eu/cell-line/ICGi007-AEthical approvalThe generation of iPSC line from cells donated by patient with informed consent was reviewed and approved by 'Center of New Medical Technology in Akademgorodok' (protocol No. 21)
Смена винтовых мод возмущений закрученного течения жидкости при подаче дисперсной газовой фазы
High-precision measurements of various hadronic cross sections are of great interest in relation with the problem of the muon anomalous magnetic moment g-2.

The cross section of the process e + e − → π + π − π + π − has been measured using an integrated luminosity of 17 pb −1 collected with the CMD-3 detector in the center-of-mass energy range 650-1000 MeV.

This measurement can be also used to test the relation between the cross section of e + e − → π + π − π + π − and the spectral function for the τ − → π − π 0 π 0 π 0 decay predicted by the conservation of vector current (CVC).
Opisthorchis felineus or Siberian liver fluke is a trematode parasite (Opisthorchiidae) that infects the hepato-biliary system of humans and other mammals. Despite its public health significance, this wide-spread Eurasian species is one of the most poorly studied human liver flukes and nothing is known about its population genetic structure and demographic history.

In this paper, we attempt to fill this gap for the first time and to explore the genetic diversity in O. felineus populations from Eastern Europe (Ukraine, European part of Russia), Northern Asia (Siberia) and Central Asia (Northern Kazakhstan). Analysis of marker DNA fragments from O. felineus mitochondrial cytochrome c oxidase subunit 1 and 3 (cox1, cox3) and nuclear rDNA internal transcribed spacer 1 (ITS1) sequences

revealed that genetic diversity is very low across the large geographic range of this species. Microevolutionary processes in populations of trematodes may well be influenced by their peculiar biology. Nevertheless, we suggest that lack of population genetics structure observed in O. felineus can be primarily explained by the Pleistocene glacial events and subsequent sudden population growth from a very limited group of founders. Rapid range expansion of O. felineus through Asian and European territories after severe bottleneck points to a high dispersal potential of this trematode species.
the previous report on increasing the informativeness of scenarios of the phenomenon

A new logic of reducing the two-time formalism to a highly informative scenario of redistribution of plasma particles in momentum due to Coulomb collisions is reported. Based on objective plasma evolution equations following from a properly reduced full plasma description

The possibilities of adapting the approach to the further development of more informative scenarios of plasma collisional relaxation and the modelling of transport phenomena are discussed.
Transition metal nitrides show a unique combination of superconducting and mechanical properties.

In this study we perform a theoretical search of the intermediate compounds in Ni-N system, determine their superconducting transition temperatures ( T c ) and bulk moduli ( K 0 ) in the wide range of pressures, from 0 to 300 GPa. We have revealed several nickel-rich interstitial compounds, Ni 5 N 2 , Ni 3 N, and Ni 6 N, and one nitrogen-rich compound, NiN 2 , as stable structures. At pressures above 100 GPa, previously unknown NiN with anti-nickeline structure is also stabilized. All found compounds are non-magnetic. The most promising for superconductivity NiN 2 structure is stable against decomposition on the mixture of (Ni+N) from 3 to at least 300 GPa. The transition from marcasite-type NiN 2 - Pnnm to pyrite-type NiN 2 - P a 3 ¯ occurs at 70 GPa. NiN 2 - Pnnm is an insulator with the band gap of about 1 eV, while NiN 2 - P a 3 ¯ is a metallic phase.

The calculated T c of NiN 2 - Pnnm equals to 10 −2 K, and the bulk modulus ( K 0 ) equals to 225 GPa at 10 GPa, which is in excellent agreement with available experimental data. The comparison of T c of compounds in the Ni-H and Ni-N systems with that of the Fe-H and Fe-N compounds, shows that hydrides and nitrides of nickel have lower T c than hydrides and nitrides of iron, which is explained by the significant differences in crystal structures.
Spatial wave modes of a viscous liquid film freely flowing down a vertical wall are considered.

In the case of small Reynolds numbers the problem is reduced to considering solutions of a nonlinear equation for the film thickness deviation from the undisturbed level. It was used to obtain a model system of equations, describing spatially periodic solutions with wave numbers lying in the vicinity of special resonance points and symmetric in the transverse coordinate.

Several solutions for this system are provided.
The first 4d/4f polyphosphides were obtained from reactions of the divalent metallocenes [Cp*2Ln(thf)2] (Ln = Sm, Yb) with [{CpMo(CO)2}2(μ,η2:2-P2)] or [Cp*Mo(CO)2(η3-P3)].

New aggregation of the central phosphorus scaffold in combination with P–P bond formation within the coordination sphere of the transition metal was observed.
Selected parameters are similar to those in the real GOL-3 experiments.

To simulate the realistic problem of continuous beam injection into a plasma, we use a 2D3V particle-in cell code allowing for the open boundary conditions in the beam direction.

It is shown that such a thin system appears to be unstable against the quasi-regular longitudinal density modulations and generates the fundamental and second harmonic emissions via the antenna mechanism. The radiation power of such an antenna is found to reach 0.6% of the total beam power.
The development of chromatin immunoprecipitation sequencing (ChIP-seq) technology has revolutionized the genetic analysis of the basic mechanisms underlying transcription regulation and led to accumulation of information about a huge amount of DNA sequences. There are a lot of web services which are currently available for de novo motif discovery in datasets containing information about DNA/protein binding. An enormous motif diversity makes their finding challenging. In order to avoid the difficulties, researchers use different stochastic approaches. Unfortunately, the efficiency of the motif discovery programs dramatically declines with the query set size increase. This leads to the fact that only a fraction of top 'peak' ChIP-Seq segments can be analyzed or the area of analysis should be narrowed. Thus, the motif discovery in massive datasets remains a challenging issue.

Argo_Compute Unified Device Architecture (CUDA) web service is designed to process the massive DNA data. It is a program for the detection of degenerate oligonucleotide motifs of fixed length written in 15-letter IUPAC code. Argo_CUDA is a full-exhaustive approach based on the high-performance GPU technologies.

Compared with the existing motif discovery web services, Argo_CUDA shows good prediction quality on simulated sets. The analysis of ChIP-Seq sequences revealed the motifs which correspond to known transcription factor binding sites.
Empirical evidence on the epidemiology of hypertension, diabetes and hypercholesterolemia is limited in many countries in Central and Eastern Europe. We aimed to estimate the prevalence, awareness, treatment and control of hypertension, diabetes and hypercholesterolemia in the Czech Republic, Russia, Poland and Lithuania, and to identify the risk factors for the three chronic conditions.

We analysed cross-sectional data from the HAPIEE study, including adults aged 45–69 years in the Czech Republic, Russia, Poland and Lithuania, collected between 2002 and 2008 (total sample N = 30,882). Among prevalent cases, we estimated awareness, treatment, and control of hypertension, diabetes and hypercholesterolemia by gender and country. Multivariate logistic regression was applied to identify associated risk factors.

In each country among both men and women, we found high prevalence but low control of hypertension, diabetes, and hypercholesterolemia. Awareness rates of hypertension were the lowest in both men (61.40%) and women (69.21%) in the Czech Republic, while awareness rates of hypercholesterolemia were the highest in both men (46.51%) and women (51.20%) in Poland. Polish participants also had the highest rates of awareness (77.37% in men and 79.53% in women), treatment (71.99% in men and 74.87% in women) and control (30.98% in men and 38.08% in women) of diabetes. The common risk factors for the three chronic conditions were age, gender, education, obesity and alcohol consumption. Patterns of awareness, treatment and control rates of hypertension, diabetes and hypercholesterolemia differed by country. Efforts should be made in all four countries to control these conditions, including implementation of international guidelines in everyday practice to improve detection and effective management of these conditions.
Gene duplication and the preservation of both copies during evolution is an intriguing evolutionary phenomenon. Their preservation is related to the function they perform. The central component of centromere specification and function is the centromere-specific histone H3 (CENH3). Some cereal species (maize, rice) have one copy of the gene encoding this protein, while some (wheat, barley, rye) have two. Therefore, they represent a good model for a comparative study of the functional activity of the duplicated