Hengzongshu/ArticleAgent huggingface dataset:
To achieve a high activity and coking stability of nickel catalysts in dry reforming of methane, materials comprised of ceria–zirconia doped by Ti were investigated as supports. Ceria–zirconia supports doped with titanium were prepared either via the Pechini method or by synthesis in supercritical alcohol media. Ni-containing catalysts were prepared by two techniques: standard incipient wetness impregnation and one-pot synthesis. The catalytic reaction of DRM to synthesis gas was carried out in the 600–750 °C range over 5% wt. Ni/Ce(Ti)ZrO2. Dried and calcined supports and catalysts were characterized by physicochemical methods including N2 adsorption, XRD, Raman, H2-TPR, and HRTEM. Both preparation methods led to formation of solid solution with cubic fluorite-like structure, as well as after addition of Ti. Introduction of Ti should provide improved oxygen storage capacity and mobility of support oxygen. The highest activity was observed with the catalyst of 5% wt. Ni/Ce0.75Ti0.2Zr0.05O2−δ composition due to optimized oxide support structure and support oxygen mobility.
BIOLOGICAL SMALL MOLECULES C275 hydrogen bonds system (intra-and intermolecular ones) and crystal packing are also discussed.The crystal packing are stabilized by -interactions between benzene rings and/or triazole heterocycles.The packing coefficient and solvent accessible potential area in crystal were also analyzed.
The subject of this paper is molecular stochastic modeling the transport processes in liquids. The proposed method and the corresponding algorithm are an alternative to the molecular dynamics method. However, unlike the latter the system of Newtonian equations is not solved for modeling the phase trajectories of the system studied. The phase trajectories of the molecular system are simulated stochastically. For this purpose, the database of the intermolecular forces acting on each molecule of the system during the considered time interval has been created. The distribution function of these forces has been built. It was shown that this distribution function can be approximated by certain analytic function. The dependency of the parameters of this function on the liquid temperature and parameters of the intermolecular interaction potential (the Lennard-Jones interaction potential is used) is determined. Using this distribution function the force acting on each molecule at given time is determined. After that the coordinates and velocity of all molecules of the system are calculated. As a result, the full information about the phase variables of the molecular system is obtained. All macroscopic characteristics of the system (temperature, pressure, transport coefficients etc.) are calculated by means of the methods of nonequilibrium statistical mechanics. The transport coefficients are calculated using fluctuation-dissipation theorems that relate transport coefficients to the evolution of the corresponding correlation functions. The algorithm was tested on the calculation of the viscosity of several simple liquids.
In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals. However, the mechanisms of this reduction have yet to be resolved. In recent years, attention has been paid to differences in miRNA expression patterns between animals with different behavior and stress reactivity, as well as to miRNA regulation under stress. The same applies to NR3C1 mRNA as well.

In this work, we used an experimental domestication model, the silver fox selected for many years for the response to humans to study cortisol stress reactivity in tame and aggressive foxes in response to immobilization in human arms. Additionally, these behavioral fox groups were explored for one of the important mechanisms of glucocorticoid negative feedback, the expression of the glucocorticoid receptor gene (NR3C1) in a portion of the dorsal hippocampus. That is why we performed a miRNA-seq analysis on a portion of the fox dorsal hippocampus.

It has been demonstrated that immobilization in human arms leads to significantly higher stressinduced cortisol levels in aggressive than tame foxes. At the same time, no differences have been found between hippocampal NR3C1 gene expression and the pattern of miRNA expression. Thus, reduced stress reactivity in foxes during selection for the absence of aggressive responses and for the presence of emotionally positive responses to humans does not seem to be associated with important mechanisms of regulation such as alterations in hippocampal NR3C1 gene expression or microRNA-mediated silencing.
Modern astroparticle physics makes wide use of machine learning methods in such problems as noise suppression, image recognition, event classification.

In this work we present a demo version of the machine-learning based application we have created, which helps students and a broader audience to get more familiar with the cosmic ray physics, and shows how machine learning methods can be used to analyze data.

The work discusses the prospects for expanding the application's functionality and methodological approaches to the development of interactive outreach materials in this area.
Diffraction of a surface wave on a rectangular wedge with impedance facets is studied using the Sommerfeld-Malyuzhinets technique. An analog of Landau's bypass rule in the theory of plasma waves is introduced for the selection of a correct branch of the Sommerfeld integral, and the exact solution is given in terms of the imaginary error function. The formula derived is valid both in the ``near wave'' and ``far wave'' zones (defined here to be located within the wave zone, in the meaning of the theory of radiation). It is shown that a diffracted surface wave is completely scattered into freely propagating electromagnetic waves and neither reflected nor transmitted surface waves are generated in the case of bare metals, which have a positive real part of the surface impedance. The scattered waves propagate predominantly at a grazing angle along the direction of propagation of the incident surface wave and mainly in the upper hemisphere regarding the wedge facet. The profile of radiated intensity is nonmonotonic and does not resemble the surface-wave profile, which exponentially evanesces with the distance from the wedge facet. Comparison with experiments carried out in the terahertz spectral range at the Novosibirsk Free-Electron Laser facility has shown a good agreement of the theory and the experiments.
The paper discusses the new monograph, published in 2019 by V. A. Artamonov, well-known researcher of the Petrine epoch. His book is dedicated to studying the military conflict between Russia and Ottoman empire in 1710–1713.

The author shows clearly that Ottoman Sultan Ahmed III and his commander in chief Mehmed Pasha had no plan of any invasions to Russia, but wanted just return to the borders before 1696 in the Priazovye region. Peter I, planning his expedition to Moldavia in 1711, did not take to consideration the experience of Austrian and Polish campaigns against Ottomans in the end of the 17th century. This led to encirclement and blockade of the Russian army by the Ottoman forces on the Pruth river (July 9–12, 1711). Under these conditions Peter I could not make a decision to fight, but preferred to negotiate peace, although Russian army was quite able to defeat enemy.

The Ottoman side willingly agreed to make peace, which was supported by giving almost 300.000 Rubles to commander in chief Mehmed Pasha and his staff. After that Russia lost some fortresses in the Priazovye region and political influence on the Christian peoples under Ottoman rule in the Balkans. This monograph could be highly recommended for academic scholars, teachers and students of higher education institutions.
Alzheimer’s disease (AD) is the most common type of dementia and is currently incurable. After unsuccessful attempts to create drugs targeting the amyloid-β pathway, a search for alternative approaches and treatments targeting nonamyloid AD pathologies is currently underway. One of them is inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity, which is increased in the prefrontal cortex of AD patients.

Here we examined effects of prolonged treatment of OXYS rats which mimic key signs of sporadic AD with a STEP inhibitor, TC-2153, on the progression of signs of AD.

TC-2153 had an ambiguous effect on the behavior of the animals: it significantly reduced the already low locomotor and exploratory activities and enhanced anxiety-related behavior in OXYS rats but improved their long-term memory in the Morris water maze. Moreover, TC-2153 had no effect on the accumulation of the amyloid-β protein and on the STEP61 protein level; the latter in the cortex and hippocampus did not differ between OXYS rats and control Wistar rats. These results suggest that the effects of prolonged treatment with TC-2153 may be mediated by mechanisms not related to STEP. In particular, TC-2153 can act as a potential hydrogen sulfide donor and thus substantially affect redox homeostasis.
The establishment of Soviet power in Barnaul is connected with tragic events for the Orthodox Church: the closing of churches, the punishment of priests who did not accept the 'godless power', confiscation of church property, and the ban on religious education for children and the preaching of the Orthodox faith.

The purpose of this research is to analyse the meaningful content of the frescoes and the system of their interaction – connectedness to the architectural space of the church. At the same time, the research concentrates primarily on the meaning of the painting programme. There will be no attempt to criticise the artistic value of paintings since it is difficult to distinguish the original message after numerous renewals and restorations.

In the context of historical events, it is appropriate to reflect on the visual narrative of the fresco painting of the Pokrovsky Cathedral and understand what is presented here: a standard set of copies of well-known examples from the capital recommended by the Holy Synod, selected by the Prior and mechanically transferred by a Siberian artist into the interior of a provincial church or an original fresco programme, although based on the well-established system of iconographic canons and images but created for the purpose, which form the codenarrative, understandable only for the believer from the 'recognisable' models and storytelling scenes, to create a unified spiritual space, 'the mirror of consciousness', sensitively reflecting the inner life of the individual (his doubts, fears, hopes), reinforcing it through the visualisation of marks of the Divine power − the analogy of his own pain with the suffering of the Son of God.
A skein invariant can be computed on each link solely by the use of skein relations and a set of initial conditions. The new procedure, remarkably, leads to generalizations of the known skein invariants.

We study new skein invariants of links based on a procedure where we first apply a given skein relation only to crossings of distinct components, so as to produce collections of unlinked knots. We then evaluate the resulting knots using the given invariant. We make skein invariants of classical links based on the invariants of knots, denoting the regular isotopy version of the Homflypt polynomial, the Kauffman polynomial and the Dubrovnik polynomial. We provide skein theoretic proofs of the well-definedness of these invariants.

These invariants are also reformulated into summations of the generating invariants on sublinks of a given link, obtained by partitioning into collections of sublinks. These summations exhibit the tight and surprising relationship between our generalized skein-theoretic procedure and the structure of sublinks of a given link.
We search for CP violation in Cabibbo-suppressed charged D meson decays by measuring the difference between the CP-violating asymmetries for the Cabibbo-suppressed decays D(±)→K(+)K(-)π(±) and the Cabibbo-favored decays D(s)(±)→K(+)K(-)π(±) in the K(+)K(-) mass region of the ϕ resonance. Using 955 fb(-1) of data collected with the Belle detector, we obtain A(CP)(D+→ϕπ+)=(+0.51±0.28±0.05)%. The measurement improves the sensitivity of previous searches by more than a factor of 5. We find no evidence for direct CP violation.
Intensive research on the Mesolithic of western Central Asia began in the mid twentieth century

when the discovery of key sites allowed for the formulation of the main regional cultural-chronological schemes
The only alternative assignment allowed by previous measurements, JPC=2-+

angular correlations in B+ to X(3872) K+ decays, where X(3872) to pi+pi- J/psi and J/psi to \mu+\mu-. The data correspond to 1.0 fb-1 of pp collisions collected by the LHCb detector. using the likelihood-ratio test in the full angular phase space

The quantum numbers of the X(3872) meson are determined to be JPC = 1++. is rejected with a confidence level equivalent to more than eight Gaussian standard deviations. This result favors exotic explanations of the X(3872) state
Aging is the major risk factor of the most common (~95% of cases) sporadic Alzheimer's disease (AD). Accumulating data indicate that middle age as a critical period for the relevant pathological processes; however, the question of when AD starts to develop remains open. It has been reported only recently that in the early postnatal period—when brain development is completing—preconditions for a decrease in cognitive abilities and for accelerated aging can form. Here, we hypothesized that specific features of early postnatal brain development may be considered some of the prerequisites of AD development at an advanced age. To test this hypothesis, we used OXYS rats, which are a suitable model of sporadic AD. The duration of gestation, litter size, and weight at birth were lower in OXYS rats compared to control Wistar rats. The shortened duration of gestation may result in developmental retardation. Indeed, we noted decreased locomotor activity and increased anxiety in OXYS rats already at a young age: possible signs of altered brain development. We demonstrated retardation of the peak of postnatal neurogenesis in the hippocampal dentate gyrus of OXYS rats. Delayed neuronal maturation led to alterations of mossy-fiber formation: a shortened suprapyramidal bundle and longer infrapyramidal bundle, less pronounced fasciculation of granule cells' axons, and smaller size and irregular shape of nuclei in the CA3 pyramidal layer. These changes were accompanied by altered astrocytic migration. The observed features of early development may be considered some of the risk factors of the AD-like pathology that manifests itself in OXYS rats late in life.
In this work we studied transition mechanics of a dynamic hydrogen bond network of water into a stable hydrogen bond network during gas clathrate hydrate formation process. For this purpose, we used Molecular Dynamic simulation methods and a bunch of home-made programs for determining structural properties during transition process. We have found that at certain conditions the network transformation process involves the whole system from the very beginning and could be considered as a collective effect, that results in high speed of hydrate formation.
This paper aims at experimental study of gas-liquid flow in a horizontal rectangular hydrophilic microchannel with a cross-section of 200×400 μm. The ethanol and nitrogen are used as working liquids and gas accordingly in the microchannel with crossflow T-mixer at the channel inlet. Experimental data are obtained using high-speed visualization, laser flow scanning, and LIF method. The elongated bubble flow and transition flow are observed in the hydrophilic rectangular microchannel depending on gas and liquid flow rates. Using the LIF method, the non-uniform liquid film distribution is observed in the channel cross-section. The liquid film thickness is measured for elongated bubble flow and transition flow and compared with the Taylor law.
Epilepsy is a common manifestation of mitochondrial disorders, in addition mitochondrial oxidative stress may play an important role in epileptogenesis since it affects the excitability of neurons. Mitochondrial diseases are often difficult to diagnose unless the symptoms are clearly identified as a part of a specific mitochondrial mutation. The use of next-generation sequencing would lead to the rapid identification of genes associated with epilepsy syndromes.

In this study, we evaluate the applicability of the NGS method for diagnosis of mitochondrial epilepsy by clinicians and laboratories in Kazakhstan. We performed complete mitochondrial genome sequencing on the Illumina MiSeq platform for 6 patients with epilepsy. Using the MITOMAP and HmtDB databases, we identified three pathogenic variants (MT-ND1 m.3697G> A, m.5628T> C and m.7547T> C) leading to the development of epilepsy, additionally we found 6 variable sites (m.5586C> T, m.10095C> T, 514_515delCA, 16180_16181delAA, C514.CACACA, A955. ACCCC), the clinic of which was not previously mentioned in the literature.

Our preliminary study suggests that mitochondrial genes potentially play a role in the pathogenesis of epilepsy and mutations in these genes cause various forms of epilepsy. It is necessary to elucidate the main mechanisms and participation of variants of mtDNA haplogroups in the development of epilepsy to apply the NGS method in diagnosis of mitochondrial epilepsy.
We consider the problems of the authorship of literary texts in the framework of the quantitative study of literature.

This article proposes a methodology for authorship attribution of literary texts based on the use of data compressors. Unlike other methods, the suggested one gives a possibility to make statistically verified results.

This method is used to solve two problems of attribution in Russian literature.
316 Objectives One of the major innovations made in recent years is combined PET/MRI, but utilization of depth-of-interaction (DOI) measurement in PET detectors has not been studied well. DOI measurement, which allows for use of a smaller detector ring, is essential for PET in order to exploit the excellent potentials of PET imaging in terms of improved spatial resolution and sensitivity as well as reduced production costs of PET instrument. In this paper, therefore, we proposed a new combined PET/MRI that makes full use of DOI measurement. Methods In order to make a PET detector ring as small as possible while placing electronic parts such as photodetectors and front-end circuits outside of a RF coil, PET detector modules were placed between spokes of the birdcage RF coil. For each detector module, electronic parts were covered with a Cu shielding box with a hole in front of the photodetectors, and scintillators were sticking out of the shielding box to allow their placement inside of the birdcage coil. In theory, the proposed birdcage coil integrated with PET detectors can be applied to any existing MRI as an additional choice of RF coils. For a proof-of-concept, we developed a full-ring prototype (4-layerd arrays of 2.0mm-LYSO with MPPCs), which was applied to a 3.0 T MRI (MAGNETOM Verio, Siemens). Results After evaluating interference between PET and MRI, no undesirable effect was seen in the PET imaging in terms of energy resolution and position identification. While a uniform static magnetic field was obtained, about a 20% decrease in signal-to-noise ratio was observed in MR images; we suspected this was due to noise contamination from outside the MRI room. Conclusions Although further optimization is required for shielding, we demonstrated a proof-of-concept of the proposed head coil with DOI PET detectors.
Natural pulsation development is considered in order to verify the linear and nonlinear region of transition process in supersonic boundary layers. To define the regions statistical approach is used. The typical way to see the linear disturbance development is to consist in verification of the normality distribution for pulsation amplitude measured by hot-wire. More complicated task is to determine the initial disturbance amplitudes in supersonic boundary layer in quantities of velocity, density and temperature and its relations during transition process. Solving such a problem scanning constant temperature anemometer is necessary to apply. Pulsation decomposition procedure is analyzed and used for measured data.
Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk.

We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them. The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample from the southwestern Netherlands. Variance components linkage analyses were performed using Merlin. Regions of interest (LOD > 1.9) were fine-mapped using microarray and exome sequence data.

We observed one significant LOD score for the second principal component on chromosome 15 (LOD score = 3.01) and 12 suggestive LOD scores. Several loci contained variants identified in GWAS for these traits; however, these did not explain the linkage peaks, nor did other common variants. Exome sequence data identified two associated variants after multiple testing corrections were applied. We did not find common SNPs explaining these linkage signals. Exome sequencing uncovered a relatively rare variant in MAPK3K11 on chromosome 11 (MAF = 0.01) that helped account for the suggestive linkage peak observed for the first principal component. Conditional analysis revealed a drop in LOD from 2.01 to 0.88 for MAP3K11, suggesting that this variant may partially explain the linkage signal at this chromosomal location. MAP3K11 is related to the JNK pathway and is a pro-apoptotic kinase that plays an important role in the induction of cardiomyocyte apoptosis in various pathologies, including LVH.
The importance of polymorphism of molecular crystals is hard to overestimate, especially when dealing with compounds used as materials or drugs. Different polymorphs of a drug substance may have different properties related to their manufacturing, therapeutic usage, or storage (density, hygroscopicity, melting points, thermal stability, solubility, rate of dissolution, surface free energy, toxicity, bioavailability, tabletting, etc.). Different polymorphs, solvates, and co-crystals can be patented, and this opens the way for a competition with brand drugs. Since the energies of different polymorphs are sometimes very close, producing desirable crystalline forms is quite a challenge and can also be complicated by the phenomena of concomitant polymorphism (when several polymorphs crystallize simultaneously from the same batch), or erratic and poorly reproducible (when crystallization gives different polymorphs even at seemingly identical experimental conditions). The aim of the present study was to crystallize various solvates of furosemide, to check whether these solvates can be used as precursors for producing different polymorphs of pure furosemide on their subsequent decomposition upon heating, and to search any correlation between the crystal structures of the solvates and on the furosemide polymorphs produced by desolvation. Four solvates of furosemide with tetrahydrofuran, dioxane, dimethylformamide, and dimethylsulfoxide were crystallized. The detailed structural analysis of furosemide-containing crystal structures showed that the molecule of furosemide has a high conformational lability because of the rotations of the sulfamoyl and furanylmethylamino fragments. Some of the furosemide conformations were shown to be stabilized by the intramolecular N–H···Cl H-bond. Desolvation of the four solvates was studied by TG and X-ray diffraction and was shown to give different products depending on the precursor and particle size.