Hengzongshu/ArticleAgent huggingface dataset:
The work provides the study of quinolinium ionic liquids (ILs)—a new class of stationary phases for capillary gas chromatography (GC). Quinolinium ILs were shown to have new attractive properties. They are not only highly polar, but also very selective for aromatic compounds and oxygenates. Depending on the substituents in the quinolinium ring, the studied ILs possess polarity numbers from 64 to 99, so they are polar and strongly polar. By the variation of the substituent and its position, changes in the prevailing types of interactions with analytes are observed. It is worth noting that Abraham's constants for the quinolinium phases are significantly different from the previously known imidazolium and pyridinium ionic liquids (ILs) that cause significant variations in their selectivity. The most significant differences are observed in the π–π interactions and hydrogen bond acidity parameters. The investigation of background mass spectra for quinolinium ILs showed the most intense signals related to peaks at m/z 69 and 143 belonging to [CF3]+ and quinolinium ring fragments. The most thermostable ILs are N-propyl-6-methylqionoinium and bis(6-methylquinolinium)hexane that are stable up to 300 °C. With regard to the possible use of quinolinium ILs, apart from the separation of polar substances, it is expected that they will find applications in two-dimensional chromatography for the separation of complex mixtures compose of compounds that differ substantially in their properties. The applications of the columns for the determination of aromatic hydrocarbons in gasoline and phenolic compounds in pyrolysis biodiesel are demonstrated.
An overview of recent experimental results on instability and dynamics of jets at low Reynolds numbers is given.

Round and plane, macro and micro jets are under the consideration.

Basic features of their evolution affected by initial conditions at the nuzzle outlet and environmental perturbations are demonstrated.
The Moloney murine leukemia virus-transformed suspension cell line WMP2 is derived from wild mice (Mus musculus) of the WMP/WMP strain. These mice carry nine pairs of metacentric Robertsonian translocation chromosomes. As the chromosomes of the wild-type mouse are all acrocentric, metaphase spreads of the WMP2 cells seam to be highly suited for physical gene mapping.

Here we studied the WMP2 line using spectral karyotyping (SKY) combined with new established mouse specific multicolor banding (mcb) probes for the chromosomes X, 3, 4, 6 and 18.

SKY revealed that the WMP2 cell line developed further four derivative chromosomes. After application of mcb five previously unrecognizable intrachromosomal rearrangements with 9 breakpoints were detected for the studied chromosomes.
Superconducting technology makes it possible to build a high energy $e^+e^-$ linear collider with energy recovery (ERLC) and reusable beams. To avoid parasitic collisions inside the linacs, a twin (dual) LC is proposed. In this article, I consider the principle scheme of the collider and estimate the achievable luminosity, which is limited by collision effects and available power. Such a collider can operate in a duty cycle (DC) and in a continuous (CW) modes, if sufficient power. With current SC Nb technology ($T=1.8$ K, $f_{\rm RF}=1.3$ GHz, used for ILC) and with power $P= 100$ MW, a luminosity $L \sim 0.33 \times10^{36}\,\rm cm^{-2}s^{-1}$ is possible at the Higgs factory with $2E_0=250$ GeV. Using superconductors operating at 4.5 K with high $Q_0$ values, such as Nb$_3$Sn, and $f_{\rm RF}=0.65$ GHz, the luminosity can reach $L \sim 1.4 \times10^{36} \,\rm cm^{-2}s^{-1}$ at $2E_0=250$ GeV (with P=100 MW) and $L \sim 0.8 \times 10^{36}\,\rm cm^{-2}s^{-1}$ at $2E_0=500$ GeV (with P=150 MW), which is almost two orders of magnitude greater than at the ILC, where the beams are used only once. This technology requires additional efforts to obtain the required parameters and reliably operation. Such a collider would be the best machine for precision Higgs studies, including the measurement of Higgs self-coupling.
Denisovans are a sister group of Neandertals that were identified on the basis of a nuclear genome sequence from a bone from Denisova Cave (Siberia). The only other Denisovan specimen described to date is a molar from the same site.

We present here nuclear DNA sequences from this molar and a morphological description, as well as mitochondrial and nuclear DNA sequences from another molar from Denisova Cave, thus extending the number of Denisovan individuals known to three.

The nuclear DNA sequence diversity among the Denisovans is higher than among Neandertals, but lower than among present-day humans. The mtDNA of one molar has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over several millennia.
One of the promising ways of removing large heat fluxes from the surface of heat-stressed elements of electronic devices is the use of evaporating thin layer of liquid film, moving under the action of the gas flow in a flat channel.

In this work, a prototype of evaporative cooling system for high heat flux removal with forced circulation of liquid and gas coolants with controlled pulsation, capable to remove heat flux of up to 1,5 kW/cm2 and higher was presented. For the first time the regime with controlled pulsation is used.

Due to pulsations, it is possible to achieve high values of critical heat flux due to a brief increase in the flow rate of the liquid, which allows to "wash off" large dry spots and prevent the occurrence of zones of flow and drying.
L’article analyse le niveau de maitrise du français tel qu’il est manifesté dans les cahiers intimes d’une princesse russe, écrits en français entre 1830 et 1848.

Nous analyserons tout d’abord les marques transcodiques typiques du code switching et leur fonctionnement dans le texte, puis les erreurs de langage relevées dans les 5 cahiers analysés, qui représentent plus de 1000 pages manuscrites.

Nous arriverons à la conclusion que le niveau de langue de la diariste et de son entourage était très élevé, très faiblement marqué par des interférences avec la langue maternelle.
Novel lupane‐type triterpenoid‐isoxazole conjugates were designed by direct placing of isoxazole linker at C(17) of triterpenoid. The suggested synthetic sequence demonstrates successful combination of electro‐organic synthesis and conventional approaches. TEMPO‐mediated electrooxidation of betulin to betulinal was developed and optimized at boron‐doped diamond anodes with potassium acetate as inexpensive supporting electrolyte. Betulinal‐derived oxime was further selectively electro‐oxidized at a graphite anode to nitrile oxide, which proved to be stable and isolable species. The same reaction sequence was performed with 3β‐lupane‐3,28‐diol. Nitrile oxides were characterized by 15 N NMR and X‐ray crystallography. The isolable nitrile oxides allowed creation of isoxazole library by 1,3‐dipolar cycloaddition reactions with various alkynes. Some of the title conjugates exhibit cytostatic properties against breast cancer cell line MCF7, glioblastoma multiform cell line U‐87 MG and lung carcinoma cell line A549 with growth inhibition (GI 50 ) concentrations up to 11 μ m , while being harmless to immortalized human fibroblasts hTERT (GI 50 >100 μm ).
Decrease in natural illumination in fall/winter months causes depressive-like seasonal affective disorders in vulnerable individuals. Obesity is another risk factor of depression. The lethal yellow (AY) mutation causes ectopic expression of agouti protein in the brain. Mice heterozygous for AY mutation (AY/a) are obese compared to their wild-type littermates (a/a).

Six weeks old mouse males of AY/a and a/a lines were divided into four groups eight animals each and exposed to long- (14 h light and 10 h darkness) or short- (4 h light and 20 h darkness) day conditions for 28 days. Then the behavior of these mice was successively investigated in the home cage, open field, elevated plus-maze and forced swim tests.

We did not observed any effect of AY mutation on the general activity, water and food consumption in the home cage; locomotion and exploration in the open field test; anxiety-related behavior in the open field and elevated plus-maze tests. At the same time, AY mutation increased depressive-like immobility time in the forced swim test (F1.28 = 20.03, p = 0.00012). Shortday conditions decreased nocturnal activity in the home cage, as well as locomotion (F1.28 = 16.33, p = 0.0004) and exploration (F1.28 = 16.24, p < 0.0004) in the open field test. Moreover, short-day exposition decreased time spent in the center of the open field (F1.28 = 6.57, p = 0.016) and in the open arms of the elevated plus-maze (F1.28 = 12.08, p = 0.0017) tests and increased immobility time in the forced swim test (F1.28 = 9.95, p = 0.0038). However, no effect of the interaction between AY mutation and photoperiod on immobility time in the forced swim test was observed. Therefore, short-day photoperiod and AY mutation increased depressive-like behavior in the forced swim test by means of different mechanisms.
The commutation characteristics of TPI-type pseudospark switches, depending on the parameters of trigger circuits, are studied.

An influence of the trigger pulse rise time on the pseudosparks time jitter is explored. The double and the triple gapped deuterium and hydrogen switches were explored.

It has been shown that the pseudospark switches can be triggered on a pre-ionization electrode with a cathode and a grid, simultaneously grounded. The time jitter values of 1-2 ns on the deuterium switches triggered on the pre-ionization electrode have been achieved.
Thermal stability in combustion reaction for natural graphite, graphene and several expanded graphite phases were studied

the kinetic parameters of the oxidation reaction were calculated for two samples

Natural graphite (crystalline particles 200 -300 µm) has the maximum stability (E 1 = 201 ± 2 kJ/mol, lg A 1 = 7.1 ± 0.1), while multilayer graphene is the most reactive (E 2 = 120 ± 1 kJ mol -1 , lg A 2 = 4.3 ± 0.10). The different sample grain sizes and their different structures result in different thermal stabilities: both in the reaction zones location (i.e. in the topochemical equation forms), and in the kinetic parameters' values.
Ni-substituted Sr-aluminates Sr 1-x Ni x Al 11.2+x Ni 0.8-x O 19-δ (x = 0; 0.2; 0.4; 0.8) obtained by a precipitation method and calcined at 1200°C have been characterized by different physicochemical techniques

their catalytic properties have been tested in steam reformation of methane. It has been shown that substitution of Al 3+ and/or Sr 2+ by Ni 2+ in the aluminate structure results in changes of phase composition, specific surface area, and reducibility of samples. It has been established that the samples are not completely reduced in the temperature range of 30-900°C.

The Sr 1-x Ni x Al 11.2+x Ni 0.8-x O 19-δ (x = 0; 0.2; 0.4) catalysts are active and stable in the steam reforming of methane at 700oC: residual amount of methane is (1.1±1.0)vol.%, while the Sr 1-x Ni x Al 11.2+x Ni 0.8-x O 19-δ (x = 0.8) sample is rapidly deactivated by coking.
The February-March Plenum of the Central Committee of the All-Union Communist Party of the Bolsheviks entered the history of not only the party but also the country as a whole marking the beginning of large-scale state terror against all sectors of society.Tensions in the upper echelons of power inevitably shifted to the regional level.Events on the ground had to confirm the readiness of the regional leadership to implement the most stringent directives of the Center.

This publication, based on an analysis of the transcript of the three-day Plenary Meeting of the West Siberian Regional Committee of the Party in the second half of March 1937 is designed to answer questions about how capable regional managers turned out to be.

Considering the state of the party's organizations in the region, the level of educational and professional characteristics, the experience of the nomenclature's activity, the author concludes that the regional cadres were disoriented by the new requirements for the election of the party and Soviet bodies.The leader of the party R.I. Eiche, who could not overcome the inertia and routine of the positions of local leaders on key issues of party, state and economic activities, also experienced a state of nervousness and uncertainty.The debate on the relationship in the management work of the principles of professional competence and 'Bolshevik vigilance' also remained unfinished.
Influenza A virus (IAV) causes a respiratory infection that affects millions of people of different age groups and can lead to acute respiratory distress syndrome. Currently, host genes, receptors, and other cellular components critical for IAV replication are actively studied. One of the most convenient and accessible genome-editing tools to facilitate these studies is the CRISPR/Cas9 system. This tool allows for regulating the expression of both viral and host cell genes to enhance or impair viral entry and replication. This review considers the effect of the genome editing system on specific target genes in cells (human and chicken) in terms of subsequent changes in the influenza virus life cycle and the efficiency of virus particle production.
ПРЕЦИЗИОННЫЙ ЧЕТЫРЕХКВАДРАНТНЫЙ ИСТОЧНИК ТОКА ВЧ-500-12Р ДЛЯ ПИТАНИЯ СВЕРХПРОВОДЯЩИХ СОЛЕНОИДОВРассматривается принцип действия разработанного прецизионного регулируемого источника постоянного тока 0-500 А, с возможностью рекуперации реактивной энергии индуктивной нагрузки в сеть.В источнике использован инверторный принцип преобразования постоянного напряжения в напряжение с частотой 20 кГц с последующим синхронным выпрямлением.Нестабильность выходного тока за 8 ч непрерывной работы составляет менее 0,01 % от номинального значения тока.Примененные схемотехнические решения позволяют уменьшить
All of them are consistent with previously published results with improved precision.

The cross sections of the processes e+e−→K+K−J/ψ and K0SK0SJ/ψ are measured via initial state radiation at center-of-mass energies between the threshold and 6.0 GeV using a data sample of 980 fb−1 collected with the Belle detector on or near the Υ(nS) resonances, where n=1,2,…,5. A search for resonant structures and associated intermediate states in the cross section of the process e+e−→K+K−J/ψ is performed.

The cross sections for e+e−→K+K−J/ψ are at a few pb level and the average cross section for e+e−→K0SK0SJ/ψ is 1.8±0.6(stat)±0.3(syst) pb between 4.4 and 5.2 GeV.
The article describes the results of exploration works in the lower reaches of the Ob (Shuryshkarsky district of the YNAO) in 2021. The coastline of the right bank of the Ob was studied in three main areas: near the villages of Khashgort, Kushevat and the Sormas channel. In total, 13 pits and 2 excavation trenches were made with a total area of 70 sq. m. The coastline near the village of Khashgort revealed paleofaunal materials and stone artifacts of the Paleolithic type. The main excavations were carried out at the Kushevat Paleolithic site discovered in 2020. Archaeological and paleofaunal materials were recorded in the alluvial deposits of two excavation trenches with a total area of 44 sq.m at an unnamed inflow of the Ob. The excavations revealed tree bone-bearing layers; stone artifacts, charcoal pieces, and non-utilitarian items were recovered from the lowermost layer. Archaeological materials (2 specimens) are represented by a small spall and an exhausted core of the parallel reduction pattern. The paleofaunal material numbering 110 units (bones, horns, teeth, and fragments) is mainly represented by the remains of a reindeer.Thus, in the field season of 2021, a new locus of the surface occurrence of the Paleolithic materials was identified supporting previous identification of a cultural layer at Kushevat. As a result, taking into account the stratigraphic situation at the site and the preliminary results of radiocarbon dating, the Kushevat site is currently the northernmost and most ancient of the known Paleolithic sites known in the Ob valley. Apparently, the derived data indicate the earliest, pioneering stage of Homo sapiens sapiens habitation of the subarctic zone during MIS3 in the range of 45-30 ka BP.
The motion of shock waves through a mixture of gas and fine solid particles is studied using a model of the mechanics of heterogeneous media taking into account the difference in phase velocities, the intergranular pressure of the particles, and their finite volume concentration. The equation of state includes the volume concentration of particles.

For this model, we have analytically and numerically studied the question of what types of strong discontinuities (frozen, dispersive, frozen-dispersive, two-front) exist and are stable in the dispersed medium considered and under what conditions they occur. A numerical solution of initial-boundary-value problems is obtained using a third-order TVD scheme for approximation in space and a five-order Runge–Kutta scheme for time approximations. The corresponding solutions in the class of traveling waves are calculated.

A map of flow regimes in the form of shock waves is constructed, which makes it possible to determine the final velocity of the mixture behind the shock wave as a function of its initial velocity and the relative mass concentration of the gas phase. The above-mentioned stationary solutions for various types of shock waves are found numerically. Their stability is investigated by solving the Cauchy problem for nonstationary one-dimensional equations of the mechanics of heterogeneous media.
We present the numerical study of the statistical properties of the partially coherent quasi-CW high-Q cavity Raman fiber laser. The statistical properties are different for the radiation generated at the spectrum center or spectral wings. It is found that rare extreme events are generated at the far spectral wings at one pass only. The mechanism of the extreme events generation is a turbulent-like four-wave mixing of numerous longitudinal generation modes. The similar mechanism of extreme waves appearance during the laser generation could be important in other types of fiber lasers.
It was found that antibodies (Abs) against myelin basic protein (MBP) are the major components of the antibody response in multiple sclerosis (MS) patients. We have recently shown that IgGs from sera of MS patients are active in the hydrolysis of MBP. However, in literature there are no available data concerning possible MBP-hydrolyzing Abs in cerebrospinal fluid (CSF) of MS patients.

We have shown that the average content of IgGs in their sera is about 195-fold higher than that in their CSF. Here we have compared, for the first time, the average content of lambda- and kappa-IgGs as well as IgGs of four different subclasses (IgG1-IgG4) in CSF and sera of MS patients. The average relative content of lambda-IgGs and kappa –IgGs in the case of CSFs (8.0 and 92.0%) and sera (12.3 and 87.7%) are comparable, while IgG1, IgG2, IgG3, and IgG4: CSF - 40.4, 49.0, 8.2, and 2.5% of total IgGs, respectively and the sera - 53.6, 36.0, 5.6, and 4.8%, decreased in different order. Electrophoretically and immunologically homogeneous IgGs were obtained by sequential affinity chromatography of the CSF proteins on protein G-Sepharose and FPLC gel filtration.

We present first evidence showing that IgGs from CSF efficiently hydrolyze MBP and that their average specific catalytic activity is unpredictably ∼54-fold higher than that of Abs from sera of the same MS patients. Some possible reasons of these findings are discussed. We suggest that anti-MBP abzymes of CSF may promote important neuropathologic mechanisms in this chronic inflammatory disorder and in MS pathogenesis development.
expert in the field of interfacial heat and mass transfer and the founding Editor-in-Chief of the journal Interfacial Phenomena and Heat Transfer (IPHT), celebrated his 60th birthday.To mark the occasion, several of his colleagues conceived the idea of a special issue to celebrate his achievements and to provide an overview of some
The tests were carried out in the hot-shot wind tunnel IT-302M ITAM SB RAS in the attached pipe-line mode with Men = 3.

Numerical simulation was performed using ANSYS FLUENT in a three-dimensional formulation.

Satisfactory agreement between the calculated and experimental data is shown. The zones are determined in the section of the combustion chamber with a constant cross-sectional area of possible self-ignition of hydrogen with distributed injection from the pylons from the point of view of satisfying the ignition parameters. Ignition parameters are understood as static pressure and temperature levels, as well as ignition limits for local fuel-air equivalence ratio.
The Thermoactinomyces sp. strain Gus2-1 was isolated from hot-spring sediments sample from the hot-spring Gusikha in Bargusin Valley (Baikal Rift Zone, Russia). The sequenced and annotated genome is 2,623,309 bp and encodes 2513 genes. The draft genome sequence of the Thermoactinomyces sp. strain Gus2-1 has been deposited at DDBJ/EMBL/GenBank under the accession JPZM01000000 and the sequences could be found at the site https://www.ncbi.nlm.nih.gov/nuccore/JPZM01000000.
Kerr spatial self-cleaning of a pulsed beam can be obtained in an amplifying multimode optical fiber.

An input peak power of 500 W only was sufficient to produce a quasi-single-mode emission from the double-clad ytterbium doped multimode fiber (YMMF) with non-parabolic refractive index profile. We compare the self-cleaning behavior observed in the same fiber with loss and with gain.

Laser gain introduces new opportunities to achieve spatial self-cleaning of light in multimode fibers at a relatively low power threshold.
Chromodomain-containing LTR retrotransposons are one of the most successful groups of mobile elements in plant genomes. Previously, we demonstrated that two types of chromodomains (CHDs) are carried by plant LTR retrotransposons. Chromodomains from group I (CHD_I) were detected only in Tcn1-like LTR retrotransposons from nonseed plants such as mosses (including the model moss species Physcomitrella) and lycophytes (the Selaginella species). LTR retrotransposon chromodomains from group II (CHD_II) have been described from a wide range of higher plants.

In the present study, we performed computer-based mining of plant LTR retrotransposon CHDs from diverse plants with an emphasis on spike-moss Selaginella. Our extended comparative and phylogenetic analysis demonstrated that two types of CHDs are present only in the Selaginella genome, which puts this species in a unique position among plants.

It appears that a transition from CHD_I to CHD_II and further diversification occurred in the evolutionary history of plant LTR retrotransposons at approximately 400 MYA and most probably was associated with the evolution of chromatin organization.
TDP1 is an important DNA repair enzyme and a promising target for the development of new chemosensitizing agents.

A panel of isogenic clones of the HEK293FT cell line knockout for the TDP1 gene was created using the CRISPR-Cas9 system. Cytotoxic effects of topotecan (Tpc) and non-cytotoxic compounds of the new structures were investigated separately and jointly in the TDP1 gene knockout cells.

For two TDP1 inhibitors, 11h and 12k, a synergistic effect was observed with Tpc in the HEK293FT cells but was not found in TDP1 −/− cells. Thus, it is likely that the synergistic effect is caused by inhibition of TDP1. Synergy was also found for 11h in other cancer cell lines. Thus, sensitizing cancer cells using a non-cytotoxic drug can enhance the efficacy of currently used pharmaceuticals and, concomitantly, reduce toxic side effects.