Hengzongshu/ArticleAgent huggingface dataset:
Primary hyperaldosteronism is a common cause of hypertension.Its prevalence reaches 15% among the forms of arterial hypertension.Prolonged exposure to elevated aldosterone concentrations is associated with target organ damage in the heart, kidney, arterial wall, and high cardiovascular risk in patients with primary hyperaldosteronism.However, the lack of attention to this problem persists among doctors of various specialties, especially general practitioners.

Timely diagnosis and treatment of these patients depends on the correct choice of screening and clarifying diagnostic methods.

A long ten-year diagnostic way to identify primary hyperaldosteronism in a young person with refractory hypertension is described below.
The human immunodeficiency virus (HIV-1) poses a serious risk to global public health. The development of a safe and effective vaccine could stop the HIV/AIDS pandemic. Much of the research focused on HIV-1 prevention through vaccination is aimed at developing immunogens and immunization strategies to induce the formation of antibodies with neutralizing activity against a broad range of HIV-1 isolates (bNAbs). The objective of this study was to develop immunogens capable of targeting an immune response to MPER, one of the regions of bNAb binding in Env. Two immunogens carrying MPER fragments on their scaffolds (protein YkuJ Bacillus subtilis and artificial polypeptide TBI) were constructed. Circular dichroism spectroscopy was used to show that the secondary structure of the immunogens was consistent with their theoretical models. The antigenic structure of the MPER-TBI and YkuJ-MPER proteins was characterized using bNAbs that recognize HIV-1 MPER (2F5, 4E10, and 10E8). The rabbit model made it possible to show the immunogenicity of the constructed recombinant proteins. The resulting serum was found to be cross-reactive with immunogens carrying MPER. The constructs designed and characterized in this study can be used for targeting the humoral immune response to MPER, which is known to be one of the sites of HIV-1 vulnerability.
Microsymposia intercalated Na1-xCoO2-x, spin-state transitions of the Co 3+ ion in LaCoO3, a metal-insulator (MI) accompanied by structural transition in LnBaCo2O5.5 (where Ln is a rare earth).We present our recent results on crystal growth of cobaltites: La1-xSrxCoO3 and LnBaCo2O5+x using Optical Travelling Solvent Floating Zone method.The crystals were studied by different techniques and some of results will be discussed.A very small Sr doping level (0.2%) drastically changes magnetic properties of La1-xSrxCoO3 as found using inelastic neutron scattering and magnetisation measurements.This can be explained assuming that the slight hole doping in LaCoO3 matrix creates magnetic polarons, which leads to a spin-state transition of Co 3+ .On the background of the spin-state and orbitalordering transitions of the Co 3+ ion in LnBaCo2O5+x, the system shows a metal-insulator transition accompanied by structural one at temperatures above room temperature, three different magnetic phases below room temperature and a structural transition at temperature above MI transition.All these properties can be tuned by a kind of the rare earth ion and oxygen stoichiometry.Structural, magnetic and transport studies of layered cobaltites LnBaCo2O5.5 (Ln=Tb, Nd) especially near metal-insulator transition will be presented.
Vaccinia virus (VACV) oncolytic therapy has been successful in a number of tumor models. Lactaptin has previously been demonstrated to act as a tumor suppressor in mouse hepatoma as well as MDA-MB-231 human adenocarcinoma cells grafted into SCID mice.

In this study our goal was to generate a double recombinant vaccinia virus (VV-GMCSF-Lact) with enhanced antitumor activity that expresses exogenous proteins: the antitumor protein lactaptin and human granulocyte-macrophage colony-stimulating factor (GM-CSF). VV-GMCSF-Lact was engineered from Lister strain (L-IVP) vaccinia virus and has deletions of the viral thymidine kinase and vaccinia growth factor genes. Cell culture experiments revealed that engineered VV-GMCSF-Lact induced the death of cultured cancer cells more efficiently than recombinant VACV coding only GM-CSF (VV-GMCSF-dGF). Normal human MCF-10A cells were resistant to both recombinants up to 10 PFU/cell. The selectivity index for breast cancer cells measured in pair cultures MCF-7/MCF-10A was 200 for recombinant VV-GMCSF-Lact coding lactaptin and 100 for VV-GMCSF-dGF. Using flow cytometry we demonstrated that both recombinants induced apoptosis in treated cells but that the rate in the cells with active caspase-3 and -7 was higher after treatment with VV-GMCSF-Lact than with VV-GMCSF-dGF. Tumor growth inhibition and survival outcomes after VV-GMCSF-Lact treatment were estimated using immunodeficient and immunocompetent mice models.

We observed that VV-GMCSF-Lact efficiently delays the growth of sensitive and chemoresistant tumors. These results demonstrate that recombinant VACVs coding an apoptosis-inducing protein have good therapeutic potential against chemoresistant tumors. Our data will also stimulate further investigation of coding lactaptin double recombinant VACV in clinical settings.
Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the first year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy.

More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse.

Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins and the enzymes responsible for their modification and degradation.
Coronavirus SARS-CoV-2 caused the pandemic of COVID-19, a respiratory disease with relatively high mortality.It is important to understand the extent to which health-related factors influence on the risk of severe COVID-19 symptoms development.It can help the health care system to save more lives, and governments to take reasonable actions.We aimed to estimate the associations between the severity of COVID-19 infection and previously suggested health-related risk factors using the methods of human quantitative genetics.First, we collected summary statistics of one GWAS for COVID-19 severity and of 6 GWASes for previously suggested risk factors.We unified summary statistics from these analyses, performed quality control, and imported the data to the GWAS-MAP platform.Then, using these summary statistics we performed Mendelian randomization analysis and obtained the estimates of associations between COVID-19 severity and several previously suggested risk factors.Although our estimates of Odds Ratio are directionally consistent with previous estimates obtained from retrospective epidemiological studies, they are not significant.
We report on measurements of the mass and lifetime of the ${\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}}$ baryon using about 1800 ${\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}}$ decays reconstructed in a proton-proton collision data set corresponding to an integrated luminosity of $3.0\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ collected by the LHCb experiment. The decays are reconstructed in the ${\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}}\ensuremath{\rightarrow}{\mathrm{\ensuremath{\Xi}}}_{c}^{0}{\ensuremath{\pi}}^{\ensuremath{-}}$, ${\mathrm{\ensuremath{\Xi}}}_{c}^{0}\ensuremath{\rightarrow}p{K}^{\ensuremath{-}}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ channel and the mass and lifetime are measured using the ${\mathrm{\ensuremath{\Lambda}}}_{b}^{0}\ensuremath{\rightarrow}{\mathrm{\ensuremath{\Lambda}}}_{c}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ mode as a reference. We measure $M({\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}})\ensuremath{-}M({\mathrm{\ensuremath{\Lambda}}}_{b}^{0})=178.36\ifmmode\pm\else\textpm\fi{}0.46\ifmmode\pm\else\textpm\fi{}0.16\text{ }\text{ }\mathrm{MeV}/{c}^{2}$, $({\ensuremath{\tau}}_{{\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}}}/{\ensuremath{\tau}}_{{\mathrm{\ensuremath{\Lambda}}}_{b}^{0}})=1.089\ifmmode\pm\else\textpm\fi{}0.026\ifmmode\pm\else\textpm\fi{}0.011$, where the uncertainties are statistical and systematic, respectively. These results lead to a factor of 2 better precision on the ${\mathrm{\ensuremath{\Xi}}}_{b}^{\ensuremath{-}}$ mass and lifetime compared to previous best measurements, and are consistent with theoretical expectations.
The PDBSite database provides comprehensive structural and functional information on various protein sites (post-translational modification, catalytic active, organic and inorganic ligand binding, protein–protein, protein–DNA and protein–RNA interactions) in the Protein Data Bank (PDB). The PDBSite is available online at http://wwwmgs.bionet.nsc.ru/mgs/gnw/pdbsite/ . It consists of functional sites extracted from PDB using the SITE records and of an additional set containing the protein interaction sites inferred from the contact residues in heterocomplexes. The PDBSite was set up by automated processing of the PDB. The PDBSite database can be queried through the functional description and the structural characteristics of the site and its environment. The PDBSite is integrated with the PDBSiteScan tool allowing structural comparisons of a protein against the functional sites. The PDBSite enables the recognition of functional sites in protein tertiary structures, providing annotation of function through structure. The PDBSite is updated after each new PDB release.
In order to produce highly adaptive, stress resistant commercial cultivars of the new generation, it is necessary to use previously unused features, wider genetic diversity and diversification.This will ensure national food security.However, for its scientific support it is necessary to obtain new genetic knowledge.Especially it concerns architectonics of plants and creation of their model of the future cultivars.
It is represented in an article the history of the Turks till the second half of the 1st millennium A.D., from migration period out of Central Asian steppes to boundaries of the Chinese empire and their resettlement to the Altai Mountains, when the Old Turkic state was at its greatest height, took control the number of sedentary agriculturist oases and successfully confronted the major powers of that time - Chinese Persian and Byzantine empires. Throughout the vast territory of the Sayan and Altai Mountains and Central Asian region there are represented all major types of funerary and memorial constructions of the Old Turks, which constitutes burial places according to the ritual of inhumation accompanied by riding horses or rams and memorial complexes in the form of vertically dug stone plates fences with vertically fixed stone steles. Authors of the article consider designated historical period of the Old Turkic history from the perspective of interaction of the Old Turks and Kyrgyz, who resided in the territory of Minusinsk Hollow. Mutual relations between those two peoples took various forms in different times: unabashedly hostile passively feudatory, when the Yenisei Kyrgyz preferred not to show pure resistance to the Turks. However, such instability of their own position has not disturbed the Kyrgyz to expand the range of their own vassals.
Optical rogue waves emerge in nonlinear optical systems with extremely large amplitudes, and leave without a trace.

In this work, we reveal the emergence of optical polarization rogue waves in supercontinuum generation from a zero-dispersion fiber, pumped by a dissipative soliton laser. Flat spectral broadening is achieved by modulation instability, followed by cascaded four-wave-mixing. In this process, we identify the emergence of optical polarization rogue waves, based on the probability density function of the relative distance among polarization states.

Experimental results show that optical polarization rogue waves originate from vector multi-wave-mixing. Besides, we observe double peaks, and even triple peaks in the histogram of the state of polarization. This is a new and intriguing property, never observed so far in optical rogue waves, for example those emerging in the statistics of pulse intensities. Our polarization domain statistical analysis provides a new insight into the still debated topic of the mechanism for rogue wave generation in optical supercontinuum.
First in the Au-Te-Se-S system (where Te ≥ Se + S) quadruple chalcogenides were obtained by dry synthesis: AuX (AuTe0,7Se0,2S0,1), Au3X10 (Au3Te6Se3S, Au3Te6Se2,5S1,5) и AuX2 (AuTe1,8Se0,2, AuTe1,8Se0,1S0,1). According to the results of X-ray phase analysis, the synthetic phases of the composition AuTe1,8(Se,S)0,2 correspond to the calaverite (AuTe2). The unidentified peaks on the diffractograms belong to the new gold chalcogenides AuTe0,7Se0,2S0,1 and Au3Te6(Se,S)4. Obviously, they are synthetic analogues of compounds previously unknown in nature, found on the Gatching occurence of the Maleteuyamsky ore field (Central Kamchatka volcanic belt). The compositions of natural phases cover the intervals: 1) Au0,99-1,00Te0,70-0,71Se0,25-0,27S0,03-0,06; 2) Au2,91-3,08Te5,85-6,06Se1,57-3,66S2,63-0,44. Raman spectra of synthetic and natural gold chalcogenides with a similar composition have identical character.
A group classification of equations describing the motion of a liquid metal with the inclusion of nanopowder inoculators is carried out in relation to the dependence of the viscosity coefficient on temperature and the fraction of the solid phase in the melt. The motion of a liquid metal with the inclusion of nanopowder inoculators will be described by the Navier— Stokes system of equations in an axisymmetric coordinate system taking into account the force of gravity directed against the axial coordinate and the heat transfer equation in a liquid, taking into account crystallization. The viscosity of a liquid is considered dependent on temperature and the fraction of the solid phase in the melt. The widest permissible group is obtained in the case of a constant viscosity coefficient. Also, the expansion of the permissible group occurs with some special types of dependence of the viscosity coefficient on temperature and the fraction of the solid phase in the melt.
Technology of reprogramming of somatic cells to a pluripotent state allows generating induced pluripotent stem cells (iPSCs) and carrying out a broad range of studies. iPSCs can be obtained from patients suffering from inherited diseases to model the diseases and to study their pathological mechanisms at the molecular level after iPSC differentiation in relevant cell types. Another approach to model and study inherited diseases is using iPSCs from healthy donors and genome editing tools. The approach allows generating a panel of isogenic lines, which gives new opportunities in drug screening and toxicological testing. Moreover, iPSCs and their derivatives can be further used for substitutive cell therapy and transplantology.

In this study, we generated iPSCs from human embryonic fibroblasts using episomal vectors. The lines obtained expressed pluripotency markers, had a stable karyotype – 46:XY, and did not contain episome integrations into genome.

The cell lines gave rise to derivatives of three germ layers during spontaneous differentiation in vitro and in vivo.
The step-by-step Hi-C protocol is described for mosquito embryos at the 15-18 h developmental stage. In brief, we collect mosquito eggs, fix them with 3% formaldehyde, and prepare Hi-C libraries using nuclei isolated from ~1000-3000 embryos of mixed sexes. We use MboI restriction enzyme and T4-ligase to generate two biological replicates per species. Libraries can be prepared with NEBNext® Ultra™ II DNA Library Prep Kit for Illumina.

The protocol was adapted for Anopheles species and successfully verified for Culex and Aedes embryos.
As the value of κ depends on the dielectric constant ε m of the metal surface guiding the SPPs it can be used for determining ϵ m in the far infrared what other optical methods fail to do due to high reflectivity of metals.

We discuss two types of THz SPP interferometers in which the interference pattern is formed as a result of the interaction of SPP beams themselves rather than bulk waves produced by these beams. The first type of interferometers are static devices that enable one to investigate fast processes on the metal surface, while the second type are dynamic ones that make it possible to realize Fourier spectroscopy of the metal surface and its transition layer at THz frequencies.

Devices of the both types produce interferograms enabling one to determine the real and the imaginary parts of κ. The results of experiments on the interaction of THz SPPs with flat mirrors and beam – splitting plates, the key elements of the THz SPP interferometers, are presented.
We report a first measurement of inclusive B -> X_s eta decays, where X_s is a charmless state with unit strangeness. The measurement is based on a pseudo-inclusive reconstruction technique and uses a sample of 657 x 10^6 BB-bar pairs accumulated with the Belle detector at the KEKB e^+e^- collider. For M_{X_s} 1.8 GeV/c^2.
This paper is the first part of a cycle of three articles, which is a survey devoted to the discussion of problems of the unique determination of conformal type for domains in Euclidean spaces.The main goal of the survey is to present a new apparently, very interesting and yet very difficult trend in the classical geometric topic of the unique determination of convex surfaces by their intrinsic metrics.This (the first) article of the cycle relies upon the author's talk "Unique Determination of Polyhedral Domains and p-Moduli of Path Families" given at the International Conference "Metric Geometry of Surfaces and Polyhedra" (Moscow, August 2010) dedicated to the 100th anniversary of Prof. N. V. Efimov, and the article itself is an extended version of this talk.Note that the author developed problems of the unique determination of conformal type for domains in Euclidean spaces in earlier papers.In the present article, we expose new results on the problem of the unique determination of conformal type for domains in R n .In particular, we show that a (generally speaking) nonconvex bounded polyhedral domain in R n (n ≥ 4) whose boundary is an (n -1)-dimensional connected manifold of class C 0 without boundary and is representable as a finite union of pairwise nonoverlapping (n -1)-dimensional cells is uniquely determined by the relative conformal moduli of its boundary condensers.Results on the unique determination (of polyhedral domains) of isometric type are also obtained.In contrast to the classical case, these results present a new approach in which the notion of the p-modulus of path families is used.Kopylov, A.P., Unique determination of conformal type for domains.
Although it is widely accepted that, in eusocial insects, colony personality emerges from the workers’ personalities, there are only a few examples of investigations of personality at the individual level.

The review analyzes personalities in various insects with different life cycles and provides new insights into the role of individuals in directing group actions in ants. The central question of the review is how the distribution of behavioral types and cognitive responsibilities within ant colonies depends on a species’ foraging style. In the context of how workers’ behavioral traits display during foraging, a crucial question is what makes an ant a scout that discovers a new food source and mobilizes its nestmates.

In mass recruiting, tandem-running, and even in group-recruiting species displaying leadership, the division of labor between scouts and recruits appears to be ephemeral. There is only little, if any, evidence of ants’ careers and behavioral consistency as leaders. Personal traits characterize groups of individuals at the colony level but not performers of functional roles during foraging. The leader-scouting seems to be the only known system that is based on a consistent personal difference between scouting and foraging individuals.
The production of \chib1P mesons in $pp$ collisions at a centre-of-mass energy of $7\tev$ is studied using $32\invpb$ of data collected with the \lhcb detector. The $\chib1P$ mesons are reconstructed in the decay mode $\chib1P \to \Y1S\g \to \mumu\g$. The fraction of \Y1S originating from \chib1P decays in the \Y1S transverse momentum range $6 < \pt^{\Y1S} < 15\gevc$ and rapidity range $2.0 < y^{\Y1S} < 4.5$ is measured to be $(20.7\pm 5.7\pm 2.1^{+2.7}_{-5.4})%$, where the first uncertainty is statistical, the second is systematic and the last gives the range of the result due to the unknown \Y1S and \chib1P polarizations.
Levulinic acid and its esters (e.g., ethyl levulinate, EL) are platform chemicals derived from biomass feedstocks that can be converted to a variety of valuable compounds. Reductive amination of levulinates with primary amines and H2 over heterogeneous catalysts is an attractive method for the synthesis of N-alkyl-5-methyl-2-pyrrolidones, which are an environmentally friendly alternative to the common solvent N-methyl-2-pyrrolidone (NMP). In the present work, the catalytic properties of the different nickel phosphide catalysts supported on SiO2 and Al2O3 were studied in a reductive amination of EL with n-hexylamine to N-hexyl-5-methyl-2-pyrrolidone (HMP) in a flow reactor. The influence of the phosphorus precursor, reduction temperature, reactant ratio, and addition of acidic diluters on the catalyst performance was investigated. The Ni2P/SiO2 catalyst prepared using (NH4)2HPO4 and reduced at 600 °C provides the highest HMP yield, which reaches 98%. Although the presence of acid sites and a sufficient hydrogenating ability are important factors determining the pyrrolidone yield, the selectivity also depends on the specific features of EL adsorption on active catalytic sites.
Objective. The aim of the systematic review was to find an answer to the question: «does an increased blood pressure affect kidney function at young age?».

Design and methods. The following key words were used to search for relevant publications: 'hypertensive nephropathy', 'reduction of glomerular filtration rate in arterial hypertension' in Russian and English. We used 'eLIBRARY.RU — SCIENTIFIC ELECTRONIC LIBRARY' and PubMed.gov databases. The inclusion criteria were the young age of the examined patients (from 18 to 44 years), the absence of concomitant pathology. The analysis included only publications of the last 5 years (2015-2020).

Results. A total of 18 articles were selected from Russian and international databases that meet inclusion criteria. Conclusions. Based on the analysis of the literature of the last 5 years we assume that increase in blood pressure disrupts kidney function in young people. However, the current data a number of limitations. Until now, gender characteristics, risk factors for decreased renal function in hypertension in young people, and most importantly, the pathogenetic basis of renal dysfunction remain unclear.