When the Prefecture was divided between the Western and Eastern Empires in 379, the Macedonian provinces were included in Eastern Illyricum.
se je od Makedonije odcepil Stari Epir ("Epirus Vetus"), v 4. stoletju pa je bila razdeljena na Prvo Makedonijo ("Macedonia Prima") na jugu in Drugo Makedonijo ("Macedonia Secunda" ali "Macedonia Salutaris") na severu.