Benedict Cumberbatch, Peter Weller, and Alice Eve round out the film's principal cast.
Chris Pine je ponovil vlogo kapitana Jamesa T. Kirka, prav tako so ponovili svoje vloge iz predhodnega filma: Zachary Quinto, Karl-Heinz Urban, Zoe Saldana, Anton Yelchin, Simon Pegg, John Cho in Bruce Greenwood.