Earlier that year Witherspoon was chosen to portray June Carter Cash, the second wife of country-music singer and songwriter Johnny Cash, in "Walk the Line".
Njen lik, Elizabeth Masterson, je ambiciozna mlada zdravnica, ki je v komi zaradi resne prometne nesreče, ki jo je doživela; njen lik se vrne v njeno stanovanje, kjer kasneje najde pravo ljubezen.