Jennie Garth, Tori Spelling, Brian Austin Green and Ian Ziering made appearances as their "Beverly Hills, 90210" characters in the first few episodes of "Melrose Place".
Izhodišče serije temelji na prilagajanju kulturnemu šoku, ki ga doživita dvojčka Barndon Walsh (igra ga Jason Priestley) in Brenda Walsh (igra jo Shannen Doherty) potem ko sta se skupaj s svojima staršema Jimom (igra ga James Eckhouse) in Cindy (igrala Carol Potter) preselila iz Minneapolisa v Beverly Hills.