When levels are between 415 and 530 μmol/l (7 and 8.9 mg/dl), the risk is 0.5% per year, while in those with a level greater than 535 μmol/l (9 mg/dL), the risk is 4.5% per year.
Prenizko izločanje sečne kisline v ledvicah je glavni vzrok hiperurikemije v približno 90% primerov, prekomerno pa v manj kot 10%.