Among the architects, painters and sculptors who collaborated in this collective masterwork were: Enrique Egas and Pedro Gumiel (design), Francisco de Amberes and Juan de Borgoña (estofado: the technique of finishing sculpture of wood with gilding and punched patterns, and polychromy), Rodrigo Alemán, Felipe Vigarny, Diego Copín de Holanda y Sebastián de Almonacid (religious images), and Joan Peti (carving and filigree).
Kardinal Cisneros je začel delo leta 1497 in končal leta 1504.