The dengue virus genome (genetic material) contains about 11,000 nucleotide bases, which code for the three different types of protein molecules (C, prM and E) that form the virus particle and seven other types of protein molecules (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) that are only found in infected host cells and are required for replication of the virus.
Zmanjšana raven zavesti se pojavlja pri 0,5–6 % hudih primerov, za kar je lahko vzrok okužba možganov z virusom ali posredno oslabitev vitalnih organov, kot na primer jeter (jetrna encefalopatija).