There are limited studies of people over 80 years old but a recent review concluded that antihypertensive treatment reduced cardiovascular deaths and disease, but did not significantly reduce total death rates.
Na Japonskem menijo, da je smiselno začeti z enim od šestih razredov zdravil, kot so: CCB, ACEI/ARB, tiazid diuretiki, beta-zaviralci in alfa zaviralci, v Kanadi in v Evropi pa se priporoča vse razen alfa zaviralcev.