A small university (now part of the University of Perugia), had its origins in a "studium generale" that was granted to the city by Pope Gregory XI in 1736.
V desetem stoletju je papež Benedikt VII obiskal mesto Orvieto z nečakom, Filippom Albericijem, ki se je kasneje v mestu ustalil in v letu 1016 postal konzul mestne države.