She is one of four children with a half-brother, John Blyth Barrymore, who is also an actor, and two half-sisters, Blyth Dolores Barrymore and Jessica Blyth Barrymore (Brahma).
Leta 2010 je Drew Barrymore prejela nagrado Screen Actors Guild Award in nagrado Zlati globus v kategoriji za "najboljšo igralko v miniseriji ali televizijskem filmu" za upodobitev Male Edie v filmu "Sivi vrtovi".