Just a few years before his death, Alberti completed "De iciarchia" ("On Ruling the Household"), a dialogue about Florence during the Medici rule.
S florentinskim kosmografom Paolom Toscanellijem je sodeloval pri astronomiji, tesni znanosti geografije v tistem času in napisal majhno latinsko delo o geografiji "Descriptio urbis Romae" ("Panorama mesta Rim").