Jovovich has contributed tracks to several of her film soundtracks, including "The Million Dollar Hotel" (2000) and "Dummy" (2002), and has also provided songs for the soundtracks of films in which she has not acted such as "Underworld" (2003) produced by musician Danny Lohner who was the bass player in Nine Inch Nails for many years.
Maja 1999 je Milla Jovovich skupaj s Chrisom Brennerjem ustanovila eksperimentalno glasbeno skupino, imenovano Plastic Has Memory, za katero je pisala pesmi, pela in igrala električno kitaro.