.45 Schofield and .45 Colt cartridges can fit into the .454's chambers, but not the other way around because of the lengthened case (very similar to the way .38 Special cartridges can fit into the longer chambers of a .357 Magnum and .44 Special cartridges can fit into the longer chambers of a .44 Magnum).
Naboj je bil prvič predstavljen javnosti novembra 1959 v ameriški reviji "Guns and Ammo".