In 2006, Jovovich was picked up by Mango, a Spanish clothing line, as their new spokesmodel and is featured in their ad campaigns; she can also be seen in ads for Etro.
Poleg tega se je pojavila v kampanijah za modne hiše Banana Republic, Christian Dior, Donna Karan, Gap, Versace, Calvin Klein, DKNY, Coach, Giorgio Armani in H&M, draguljarno Damiani in kozmetično hišo Revlon.