In June 2007, he started dating reality personality Sarah Larson, but the couple broke up in May 2008.
Clooney je skupaj z aktivistom Johnom Prendergastom pričel s projektom Enough, je strateški svetovalec pri projektu Not On Our Watch in po obisku južnega Sudana oktobra 2010 pričel s projektom Satellite Sentinel (SSP).