Spears first performed "Me Against the Music" at the 2003 NFL Kickoff Live on September 4, 2003 at the National Mall.
Decembra 2003 je podjetje LidRock na CD vključilo še remix pesmi »Me Against the Music« brez Madonne ter pesmi dveh drugih izvajalcev založbe Jive Records, in sicer Nicka Cannona ter glasbene skupine Bowling for Soup.