The cathedral contains the works of artists such as the architects and sculptors of the Colonia family (Juan, Simón and Francisco), the sculptors Gil de Siloé, Felipe Vigarny or Juan de Anchieta, the sculptor and architect Diego de Siloé, the grillworker Cristóbal de Andino or the painter Sebastiano del Piombo ("Holy Family"), among many others.
Slog katedrale je gotski, čeprav ima v notranjosti nekaj renesančnih in baročnih okraskov.