She made her feature film debut in "Altered States" (1980), in which she had a small part.
Njeno prvo ime, "Drew", je bil pravzaprav rojstni priimek njene prababice, "Georgie Drew Barrymore"; njeno srednje ime, "Blyth", je bil originalno priimek dinastije, ki jo je našel njen pradedek, "Maurice Barrymore".