The interiors of the older churches were covered with frescos, mostly in the Late Medieval style, but also in the Early Renaissance style, begun by Giotto and continued by Masaccio in the Brancacci Chapel, both of whose works Michelangelo studied and copied in drawings.
Kipar Lorenzo Ghiberti je delal za petdeset let, da bi ustvaril bronasta vrata v krstilnico, ki jih je Michelangelo opisal kot "Vrata v paradiž".