She is currently part of a country music group with actress Shawnee Smith called Smith & Pyle.
Leta 2008 je Missi Pyle zaigrala v broadwayjski gledališki igri Marca Camolettija z naslovom "Boeing-Boeing", kjer so poleg nje zaigrali še Christine Baranski, Mark Rylance, Greg Germann, Paige Davis in Rebecca Gayheart.