The guidelines of the Infectious Diseases Society of America recommend linezolid as the first-line drug of choice for VRE meningitis, and as an alternative to vancomycin for MRSA meningitis.
Vendar je tudi primeru tovrstne uporabe le malo dokazov, saj se bakterijski endoftalmitis na splošno učinkovito zdravi z apliciranjem vankomicina neposredno v oko.