Alexander's Empire fragmented after his death, and Arachosia came under control of the Seleucid Empire, which traded it to the Mauryan dynasty of India in 305 BC.
V 3. stoletju pred našim štetjem je makedonski kralj Aleksander Veliki (znan na vzhodu kot Sikander) osvojil regijo v času osvajanja perzijskega imperija in ustanovil kolonijo "Alexandria Arachosia" (danes Kandahar).