People with major depression are less likely to follow medical recommendations for treating and preventing cardiovascular disorders, which further increases their risk of medical complications.
Depresija je povezana tudi z 1,5- do 2-krat večjim tveganjem za bolezni srca in ožilja, neodvisno od drugih znanih dejavnikov tveganja; sama po sebi je neposredno ali posredno povezana z dejavniki tveganja, kot sta kajenje in debelost.