On February 12, 2008, Parker and Morgan announced their engagement, only to break up in April 2008.
Leta 2008 je Mary-Louise Parker igrala v filmu "Kronike Spiderwick" in v Off-Broadwayski igri Sarah Ruhl, ki se je premierno predvajala v New Yorku, "Dead Man's Cell Phone", kjer je igrala poleg z nagrado Drama Desk Award nagrajene igralke Kathleen Chalfant.