The game is set in 2027, 25 years before the first game and 45 years before the second game, at a time when multinational corporations have grown in power beyond the control of national governments.
Različico za Mac OS X je 26. aprila 2012 izdalo podjetje Feral Interactive kot »Ultimate Edition«, ki vsebuje tudi sicer plačljivi dodatek, poglavje "The Missing Link".