The second group coexpresses pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and has stimulatory inputs to the VMH and inhibitory inputs to the LH.
Konkretno delujeta skupaj z drugimi hormoni za tek na hipotalamus, to je območje v možganih, ki je ključno pri regulaciji vnosa hrane in porabe energije.