The district is traversed from north-west to south-east by the railway from Sulmona to Benevento and on to Avellino, and from south-west to northeast by the railways from Caianello via Isernia to Campobasso and Termoli, from Caserta to Benevento and Foggia, and from Nocera Inferiore and Avellino to Rocchetta S. Antonio, the junction for Foggia, Spinazzola (for Barletta, Bari, and Taranto) and Potenza.
Največji reki na jugozahodu sta Liri ali Garigliano s pritoki Sacco, Volturno, Sebeto, Sarno, na severu pa Trigno, Biferno in FortoreRt Monte Gargano na vzhodu, je bil popolnoma izoliran, zato je Kampanjski vulkanski lok blizu Neaplja.