Cardinal Cisneros occupied the cardinalate office for twenty-two years; under his influence and sponsorship important works were done (perhaps the most important was the Mozarabic chapel), realised by masters of the stature of Juan Francés ("reja", or the ironwork screen, of the Mozarabic chapel), Enrique Egas, Juan de Borgoña (paintings of the Mozarabic chapel) and its grandmaster Pedro de Gumiel.
To odlično delo pripisujejo Domenico Fancelliju.