He was most probably apprenticed to the local painter Antonio di Giovanni d'Anghiari, because in documents about payments it is noted that he was working with Antonio in 1432 and May 1438.
Piero se je rodil v mestu Borgo San Sepolcro, danes v Toskani (kjer je tudi umrl), očetu Benedettu de'Franceschi, obrtniku in materi Romani di Perino da Monterchi iz florentinske in toskanske plemiške družine Franceschi.