Frusciante uses a variety of vocal styles on his solo albums, ranging from the distressed screeches on "Niandra Lades and Usually Just a T-Shirt" and "Smile from the Streets You Hold" to more conventional styles on later records.
Prvič je slišal skupino Red Hot Chili Peppers igrati na nekem koncertu leta 1985 in kmalu postal njihov oboževalec.