Khadijah is said to have had four daughters with Muhammad (Ruqayyah bint Muhammad, Umm Kulthum bint Muhammad, Zainab bint Muhammad, Fatimah Zahra) and two sons (Abd-Allah ibn Muhammad and Qasim ibn Muhammad, who both died in childhood).
Pravijo tudi, da je svoje žene navajal na dialog; poslušal je njihove nasvete in žene so razpravljale z njim ter se celo prerekale.