The city was founded in 1531 in an area called Cuetlaxcoapan, which means "where serpents change their skin", in between of two of the main indigenous settlements at the time, Tlaxcala and Cholula.
Puebla, uradno Puebla de Los Angeles, je sedež Mestne občine Puebla, glavno mesto zvezne države Puebla in eno od petih najpomembnejših španskih kolonialnih mest v Mehiki.