In a game against the Miami Heat on January 16, 2006, Bynum matched up against former Laker center Shaquille O'Neal for the first time.
2. novembra 2005 je na prvi tekmi sezone proti ekipi Denver Nuggets igral 6 minut in tako postal najmlajši, ki je kdajkoli zaigral na NBA tekmi, pri starosti 18 let in 6 dni.