In the second round, he defeated Ernests Gulbis 6–4, 4–6, 7–6, and then came back to beat Radek Štěpánek 7–6, 0–6, 7–6.
24. februarja 2008 je Nalbandian zmagal na turnirju Copa Telmex, torej na svojem domačem turnirju v Buenos Airesu v Argentini.