The team's owner and manager for its first 50 years was Connie Mack, and its Hall-of-Fame players included Chief Bender, Frank "Home Run" Baker, Jimmie Foxx, and Lefty Grove.
Ekipa je sprva imela veliko uspeha - med leti 1910 in 1913 je kar trikrat zmagala na Svetovni seriji, v letih 1929 in 1930 pa v Filadelfijo prinesla še dva naslova prvakov.