Although his birth year is usually given as 1494, both chroniclers of the Great Siege of Malta, Francisco Balbi di Correggio and Hipolito Sans, say he was 67 at the time, thereby implying that he was born in 1498.
Jean Parisot je bil daljni bratranec (preko skupnega prednika Amarica de Valette) Jean Louis de Nogareta de La Valette, prvega vojvoda Eperona.