The prominent humanist literary school of Seville included such writers as Juan de Mal Lara, Fernando de Herrera, Gutierre de Cetina, Luis Barahona de Soto, Juan de la Cueva, Gonzalo Argote de Molina, and Rodrigo Caro.
Leta 1528 je napisal Francisco Delicado roman "La lozana andaluza" in leta 1599 je Sevillian Mateo Alemán napisal prvi del "Guzmán de Alfarache", prvi pikareskni roman z znanim avtorjem.