In July 2006, Earth Biofuels announced Roberts as a spokeswoman for the company and as chair of the company's newly formed Advisory Board promoting the use of renewable fuels.
Leta 2000 je Julia Roberts govorila v ozadju dokumentarnega filma "Silent Angels" o sindromu Rett, nevrološki motnji živčnega sistema, ki so ga posneli v Los Angelesu, Baltimoreu in New Yorku.