===Late Precontact smallpox/instability===There is historical evidence suggesting that the Sinixt were heavily depopulated by one or two smallpox epidemics that preceded the arrival of Scottish and Métis fur-traders of the North West Company.
=== Late Precontact smallpox/instability ===There is historic evidence suggesting that the Sinixt were heavily depopulated by one or two smallpox epidemics that preceded the arrival of Scottish and Métis fur-traders of the North West Company.