It is used as the standard C library in Cygwin, as well as being one standard C library among several for AmigaOS version 4., devkitARM, a popular toolchain for programming homebrew software for Nintendo DS, Game Boy Advance systems and the standard PlayStation Portable homebrew SDK include Newlib as their C library, as well as devkitPPC, a popular Wii and GameCube homebrew development platform.
По состоянию на 2007, devkitARM (популярный набор программ для программирования любительского ПО для Nintendo DS и систем на базе Game Boy Advance) и PlayStation Portable homebrew SDK содержали Newlib в качестве библиотеки Си.