Operators of Constellations included TWA, Eastern Air Lines, Pan American World Airways, Air France, BOAC, KLM, Qantas, Lufthansa, Iberia Airlines, Panair do Brasil, TAP Portugal, Trans-Canada Air Lines (later renamed Air Canada), Aer Lingus, VARIG, Cubana de Aviación and Línea Aeropostal Venezolana.
Самолеты Constellation эксплуатировались такими авиалиниями как TWA, Eastern Air Lines, Pan American World Airways, Air France, BOAC, KLM, Qantas, Lufthansa, Iberia Airlines, Panair do Brasil, TAP Portugal, Trans-Canada Airlines (позже Air Canada), Aer Lingus и VARIG.