"===Main show===* LeBron James and Ashanti — presented Best Hip-Hop Video* Tony Hawk and Bam Margera — introduced Good Charlotte* Kelly Clarkson and Ludacris — presented Best R&B Video* Evanescence (Amy Lee and Ben Moody) and Sean Paul — presented Best Video from a Film* Crank Yankers — appeared in different vignettes presenting Viewer's Choice Award voting procedures* Nelly and Murphy Lee — introduced Christina Aguilera* OutKast and Iggy Pop — presented the MTV2 Award* David Spade, Mary-Kate and Ashley Olsen — presented Best Pop Video* P. Diddy — introduced Run-D.M.C.
"/"Family Affair"* Coldplay — "The Scientist"* Beyoncé (с Jay-Z) — "Baby Boy"/"Crazy in Love"* Metallica — "Are You Gonna Go My Way/Smells Like Teen Spirit/Seven Nation Army/Beat It Medley"/"Frantic"* LeBron James и Ashanti — представили Best Hip-Hop Video* Tony Hawk и Bam Margera — представили Good Charlotte* Kelly Clarkson и Ludacris — представили Best R&B Video* Evanescence (Amy Lee и Ben Moody) и Sean Paul — представили Best Video from a Film* Crank Yankers — appeared in different vignettes presenting Viewer's Choice Award voting procedures* Nelly и Murphy Lee — представили Christina Aguilera* OutKast и Iggy Pop — представили MTV2 Award* David Spade, Mary-Kate и Ashley Olsen — представили Best Pop Video* P. Diddy — представил Run-D.M.C.