at the Disco — "I Write Sins Not Tragedies"* Busta Rhymes — "Put Your Hands Where My Eyes Could See"* Missy Elliott — "The Rain (Supa Dupa Fly)"* Christina Aguilera — "Hurt"* Tenacious D — "Friendship Song"* The Killers — "Enterlude"/"When You Were Young"==Appearances=====Pre-show===* The Black Eyed Peas — introduced Fergie's performance===Main show===* Jay-Z — opened the show* Montel Williams — made a brief appearance during Jack Black's opening sequence* Lil' Kim — presented Best Male Video* André 3000 and Ciara — presented Best Hip-Hop Video* The Rock — introduced Shakira and Wyclef Jean* The cast of "" — appeared in different vignettes about Viewer's Choice voting, and later on presented Viewer's Choice* 50 Cent and LL Cool J — presented Best Female Video* Lil Jon (with E-40) — introduced Pharrell and Ludacris* Sarah Silverman — appeared in backstage skits and coverage, and later performed a stand-up routine* Kyle Gass — appeared in a couple of on-stage sequences with Jack Black and The Black Eyed Peas* Jessica Simpson — introduced Best Dance Video* Chris Brown — introduced OK Go* Shaun White — introduced a of the "Jackass: Number Two" cast's vignettes* Paris Hilton — introduced The All-American Rejects* Nick Lachey and Nicole Richie — presented Best Pop Video* Snoop Dogg — presented Best Rap Video* Diddy — introduced T.I.
at the Disco — "I Write Sins Not Tragedies"* Busta Rhymes — "Put Your Hands Where My Eyes Could See"* Missy Elliott — "The Rain (Supa Dupa Fly)"* Christina Aguilera — "Hurt"* Tenacious D — "Friendship Song"* The Killers — "Enterlude"/"When You Were Young"* The Black Eyed Peas — introduced Fergie's performance* Jay-Z — открытие шоу* Montel Williams — made a brief appearance during Jack Black's opening sequence* Lil' Kim — представила Best Male Video* André 3000 и Ciara — представили Best Hip-Hop Video* The Rock — представил Shakira и Wyclef Jean* The cast of "" — appeared in different vignettes about Viewer's Choice voting, and later on presented Viewer's Choice* 50 Cent и LL Cool J — представили Best Female Video* Lil Jon (с E-40) — представили Pharrell и Ludacris* Sarah Silverman — appeared in backstage skits and coverage, and later performed a stand-up routine* Kyle Gass — appeared in a couple of on-stage sequences with Jack Black and The Black Eyed Peas* Jessica Simpson — представила Best Dance Video* Chris Brown — представил OK Go* Shaun White — представил как "Jackass: Number Two" cast's vignettes* Paris Hilton — представила The All-American Rejects* Nick Lachey и Nicole Richie — представили Best Pop Video* Snoop Dogg — представил Best Rap Video* Diddy — представил T.I.