In World War I, the German manufacturing method consisted of a three-step reaction beginning with methylation of sodium arsenite::2 Na3AsO3 + (CH3O)2SO2 → 2 CH3AsO(ONa)2 + Na2SO4,followed by reduction of the disodium monomethylarsonate with sulfur dioxide::CH3AsO(ONa)2 + SO2 → CH3AsO + Na2SO4,subsequently reacting the monomethylarsine oxide thus formed with hydrogen chloride to yield methyldichloroarsine::CH3AsO + 2 HCl → CH3AsCl2 + H2OThe As-Cl bonds in MD are susceptible toward nucleophilic attack.
Смертельная концентрация метилдихлорарсина в воздухе ЛД50 = 3-5 мг·мин/лМетилдихлорарсин получают из арсина::AsCl3 + CH3MgCl → CH3AsCl2 + MgCl2:2 Na3AsO3 + (CH3O)2SO2 → 2 CH3AsO(ONa)2 + Na2SO4,:CH3AsO(ONa)2 + SO2 → CH3AsO + Na2SO4,:CH3AsO + 2 HCl → CH3AsCl2 + H2O*Этилдихлорарсин* Метилдииодоарсин* "John R. Cashman" Emergency Response Handbook for Chemical and Biological Agents and Weapons* Метилдихлорарсин в «Pubmed Compound» (англ.