There are five campuses on the Department of Energy's Oak Ridge reservation; the National Laboratory, the Y-12 National Security Complex, the East Tennessee Technology Park (formerly the Oak Ridge Gaseous Diffusion Plant), the Oak Ridge Institute for Science and Education, and the developing Oak Ridge Science and Technology Park, although the four other facilities are unrelated to the National Laboratory.
Также в резервации находятся East Tennessee Technology Park, Центр национальной безопасности Y-12, Oak Ridge Institute for Science and Education и Oak Ridge Science and Technology Park.