The signature SLAM codes for the hemopoietic hierarchy are:* Hematopoietic stem cells (HSC) : CD150+CD48−CD244−* Multipotent progenitor cells (MPPs) : CD150−CD48−CD244+* Lineage-restricted progenitor cells (LRPs) : CD150−CD48+CD244+* Common myeloid progenitor (CMP) : lin−SCA-1−c-kit+CD34+CD16/32mid* Granulocyte-macrophage progenitor (GMP) : lin−SCA-1−c-kit+CD34+CD16/32hi* Megakaryocyte-erythroid progenitor (MEP) : lin−SCA-1−c-kit+CD34−CD16/32lowFor HSCs, CD150+CD48− was sufficient instead of CD150+CD48−CD244− because CD48 is a ligand for CD244, and both would be positive only in the activated lineage-restricted progenitors.
The signature SLAM code for the hemopoietic hierarchy are:* Hematopoietic stem cells (HSC) : CD150+CD48-CD244-* Multipotent progenitor cells (MPPs) : CD150-CD48-CD244+* Lineage-restricted progenitor cells (LRPs) : CD150-CD48+CD244+* Common myeloid progenitor (CMP) : lin-SCA-1-c-kit+CD34+CD16/32mid* Granulocyte-macrophage progenitor (GMP) : lin-SCA-1-c-kit+CD34+CD16/32hi* Megakaryocyte-erythroid progenitor (MEP) : lin-SCA-1-c-kit+CD34-CD16/32lowFor HSCs, CD150+CD48- was sufficient instead of CD150+CD48-CD244- because CD48 is a ligand for CD244, and both would be positive only in the activated lineage-restricted progenitors.