Once PKA is activated, it phosphorylates a number of other proteins including:* enzymes that convert glycogen into glucose* enzymes that promote muscle contraction in the heart leading to an increase in heart rate* transcription factors, which regulate gene expressionSpecificity of signaling between a GPCR and its ultimate molecular target through a cAMP-dependent pathway may be achieved through formation of a multiprotein complex that includes the GPCR, adenylyl cyclase, and the effector protein.
Once PKA is activated, it phosphorylates a number of other proteins including:* enzymes that convert glycogen into glucose* enzymes that promote muscle contraction in the heart leading to an increase in heart rate* transcription factors, which regulate gene expressionSpecificity of signaling between a GPCR and its ultimate molecular target through a cAMP-dependent pathway may be achieved through formation of a multiprotein complex that includes the GPCR, adenylyl cyclase, and the effector protein.