GSFC manages operations for many NASA and international missions including the Hubble Space Telescope (HST), the Explorer program, the Discovery Program, the Earth Observing System (EOS), "INTEGRAL", MAVEN, OSIRIS-REx, the Solar and Heliospheric Observatory ("SOHO"), the Solar Dynamics Observatory ("SDO"), the Rossi X-ray Timing Explorer ("RXTE") and "Swift".
Среди программ, проводящихся под координацией GSFC: телескоп Hubble, программа Explorer, программа Discovery, Earth Observing System (EOS), INTEGRAL, MAVEN, OSIRIS-REx, обсерватория SOHO, Solar Dynamics Observatory (SDO), Rossi X-ray Timing Explorer (RXTE), Swift.