While in Rome he became friendly with Cardinal Cervini and when Cervini was elected Pope Marcello II in 1555 it looked as if Commandino would prosper with personal favours from the Pope. However Pope Marcello II died shortly after his election and Commandino continued in the service of the Duke of Urbino and Cardinal Farnese but he now returned to Urbino to carry out his duties.
Habang sa Roma siya ay naging friendly sa Cardinal Cervini at kapag Cervini ay elected Papa Marcello II sa 1555 ito tumingin bilang kung Commandino ay yumabong sa personal favours mula sa Papa. Subalit Papa Marcello II namatay sa ilang sandali lamang matapos ang kanyang Commandino halalan at patuloy sa serbisyo ng Duke of Urbino at Cardinal Farnese ngunit siya ngayon ibabalik sa Urbino upang isagawa ang kanyang tungkulin.