Von Mises worked on fluid mechanics, aerodynamics, aeronautics, statistics and probability theory. He classified his own work, not long before his death, into eight areas: practical analysis, integral and differential equations, mechanics, hydrodynamics and aerodynamics, constructive geometry, probability calculus, statistics and philosophy.
Von Mises nagtrabaho sa mga likido mechanics, aerodynamics, eronautika, statistics at probabilidad theory. He-uri-uri sa kanyang sariling trabaho, hindi na bago ang kanyang kamatayan, sa walong lugar: praktikal na pagtatasa, mahalaga at kaugalian equation, mechanics, haydrodinamika at aerodynamics, nakabubuo geometry, probabilidad calculus, statistics at pilosopiya.