At the conclusion of the Spanish-American War 270 men of this 72nd Macabebe Regiment found themselves stranded in Manila. Many shipped out to join a Spanish garrison in the Caroline Islands and the remainder slipped back into Macabebe after it was occupied by the Americans. Some of these offered to serve as native guides for U.S. forces commanded by General Henry Lawton and after authorization by General Elwell Otis, a company of "Macabebe Scouts" was formed under Lieutenant Matthew A. Batson. Macabebes won lasting notability in the operation under General Frederick Funston to capture General Aguinaldo.
Pinalawak ni Serra ang mission mula Baja, San Diego, hangang San Francisco ng Alta California sa tulong ng mga Luzon Indios (kung tawagin ng mga Mexicano ay "Chinos" sapagkat sila ay sakay mula sa mga galleon na ang lulan ay kalakal na karamihan'y gawang Tsina) at Native American Indians pamamagitan ng "encomienda sistema" o "forced labor" na ang pangakong kapalit ay kaligtasan ng kanilang kaluluwa laban sa demonyo, sa pamamagitan ng bisa ng sakramentong binyag.