Between 1565-1821 the Philippines were in fact administered from the Vice royalty of New Spain's capital, Mexico City. During this period trans-Pacific trade brought many Mexicans and Spaniards to the Philippines as sailors, crew, prisoners, slaves, adventurers and soldiers in the Manila-Acapulco Galleons which was the main form of communication between the two Spanish colonies.
Ang sinimulan ng galleon San Pedro at ng galleon Nuestra Senora de Esperanza ay pinagpatuloy nila Francisco de Galli at Sebastian Cermeno, noong taon 1594 lulan sila ng galleon mula Manila upang halughugin ang kalawakan ng California at angkinin ito para sa bayang Espana. Sa kautusan ng Haring Felipe II ng Espana, taon 1606 sa Monterey, California ay itinirik ang bandila ng Espana ng mga Kastila sa tulong ng mga naglalakihang galleon mula Manila.