There are also amphoteric exchangers that are able to exchange both cations and anions simultaneously. However, the simultaneous exchange of cations and anions can be more efficiently performed in mixed beds that contain a mixture of anion and cation exchange resins, or passing the treated solution through several different ion exchange materials.
Mayroong amphoteric exchangers na magagawang upang makipagpalitan ng parehong cations at anions nang sabay-sabay din. Gayunpaman, ang sabay-sabay na exchange ng cations at anions ay maaaring mas mahusay gumanap sa halo-halong kama na naglalaman ng halo ng anion at kation exchange resins, o pagpasa sa itinuturing na solusyon sa pamamagitan ng maraming iba't ibang mga Ion exchange materyal.