As a notable exception, if you actually ARE on a known-slow platform, like Python for example, it does make sense to sidestep it to gain performance.
Bilang isang memorable exception, kung talagang AY sa isang kilalang-mabagal platform, tulad ng sawa halimbawa, ito ay magkaroon ng kahulugan upang tumabi ito upang makakuha ng pagganap.