The lack of reaction of others to his scientific work was also a factor, as was the fact that he had been accused of magic so often in his life. Dee became more and more deeply involved in conversing with angels and spirits through Kelley and, sadly, it dominated the latter part of his life.
Ang kakulangan ng mga reaksyon ng iba sa kanyang pang-agham ng trabaho ay isang kadahilanan din, bilang ay ang katunayan na siya had been akusado ng mahiko kaya madalas sa kanyang buhay. Dee ay naging mas at mas baon sa conversing sa mga anghel at mga espiritu sa pamamagitan ng Kelley at, sadly, ito dominado ang huling bahagi ng kanyang buhay.