He showed the first signs of tuberculosis in January 1553 and various factions sought to influence his successor, particularly after May when it was clear to everyone that he was quite close to death. Edward VI died on 6 July and Lady Jane Grey, the duke of Northumberland's daughter-in-law, ruled from 10 July to 19 July before being overthrown by Mary I, a daughter of King Henry VIII.
Siya ay nagpakita sa unang palatandaan ng tuberculosis sa Enero 1553 at iba't-ibang factions sought sa impluwensiya ng kanyang kapalit, lalo na matapos ang Mayo kapag ito ay malinaw sa lahat na siya ay lubos na malapit sa kamatayan. Edward VI namatay sa 6 ng Hulyo at Lady Jane Gray, ang duke ng Northumberland's anak na babae-sa-batas, pinasiyahan mula 10 ng Hulyo sa 19 ng Hulyo bago na overthrown by Maria ko, isang anak na babae ng King Henry VIII.