An angel told Hagar that Ishmael would be the father of a great nation (Genesis 21:18) and, interestingly, that Ishmael would be “a wild donkey of a man; his hand will be against everyone and everyone’s hand against him, and he will live in hostility toward all his brothers” (Genesis 16:12).
Ito ang naging dahilan ng paglayo ng puso ni Ismael kay Isaac. Isang anghel ang nanghula kay Ismael na "ang kaniyang kamay ay magiging laban sa lahat" (Genesis 16:11-12)