He was a founder of Nacionalista Party. Osmeña is the patriarch of the prominent Osmeña family, which includes his son (former Senator Sergio Osmeña, Jr.) and his grandsons (Senators Sergio Osmeña III and John Henry Osmeña), ex-Governor (Lito Osmeña and Cebu City Mayor Tomas Osmeña).
Siya ang ama ni dating Senador Sergio Osmeña Jr. at lolo nina Senador Sergio Osmeña III, John Osmena, dating Gobernador Lito Osmena ng Cebu at Mayor Tomas Osmena.