Another factor in his depression was the death of his wife Margarete. Frege had married Margarete Lieseberg but they never had any children. Frege and his wife did adopt a son, Alfred, who went on to become an engineer, but after Frege's wife died in 1904 he seemed to sink more deeply into himself.
Iba pang kadahilanan sa kanyang depression ay ang kamatayan ng kanyang asawa Margarete. Frege had kasal Margarete Lieseberg ngunit sila ay hindi nagkaroon ng anumang mga bata. Frege at kanyang asawa ay adopt ng isang anak na lalaki, Alfred, na nagpunta sa na maging isang inhinyero, ngunit pagkatapos Frege ng asawa namatay sa 1904 siya seemed sa lababo mas matindi sa kanyang sarili.