His grandfather James Ayscough was never mentioned by Isaac in later life and the fact that James left nothing to Isaac in his will, made when the boy was ten years old, suggests that there was no love lost between the two.
Kanyang lolo James Ayscough ay hindi nabanggit sa pamamagitan ng Isaac sa susunod na buhay at ang katunayan na ang James kaliwa wala sa Isaac sa kanyang ay, kapag ginawa ang boy ay sampung taon gulang na, nagpapahiwatig na may pag-ibig ay hindi mawawala sa pagitan ng dalawang.