Statement by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory Committee (ESAC) on the scientific validity of the in vitro micronucleus test as an alternative to the in vitro chromosome aberration assay for genotoxicity testing.
I cellinjer som testas utan cytoB-behandling bör mikrokärnorna klassificeras i minst 2000 celler per testkoncentration och kontroll (83), lika fördelade mellan replikaten om sådana används.