From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human platelet-derived growth factor (PDGF) receptor mRNA, complete
Date: 29 Sep 92 10:06:52 GMT
Distribution: bionet
Checksum: 00605    11

LOCUS       HUMPDGFRA    5570 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human platelet-derived growth factor (PDGF) receptor mRNA, complete
            cds.
ACCESSION   J03278
KEYWORDS    cell surface glycoprotein; glycoprotein; kinase; tyrosine kinase.
SOURCE      Human skin fibroblast cell (SK5), cDNA to mRNA, clone phPDGFR.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5570)
  AUTHORS   Gronwald,R.G., Grant,F.J., Haldeman,B.A., Hart,C.E., O'Hara,P.J.,
            Hagen,F.S., Ross,R., Bowen-Pope,D.F. and Murray,M.J.
  TITLE     Cloning and expression of a cDNA coding for the human
            platelet-derived growth factor receptor: evidence for more than one
            receptor class
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85, 3435-3439 (1988)
  STANDARD  full staff_review
COMMENT     Draft entry and computer-readable sequence [1] kindly submitted by
            R.G.K.Gronwald, 06-APR-1988.
FEATURES             Location/Qualifiers
     CDS             357..3677
                     /product="platelet-derived growth factor receptor"
                     /gene="PDGFRB"
                     /codon_start=1
                     /translation="MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVL
                     NVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTH
                     NDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL
                     HEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSV
                     NAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSIL
                     HIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR
                     TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAG
                     HYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSA
                     CRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRC
                     TLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRW
                     KVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH
                     SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITE
                     YCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY
                     MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL
                     SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN
                     YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFY
                     NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQ
                     VDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP
                     EVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQ
                     LPDSGCPAPRAEAEDSFL"
     sig_peptide     357..452
                     /gene="PDGFRB"
                     /codon_start=1
     mat_peptide     453..3674
                     /product="platelet-derived growth factor receptor"
                     /gene="PDGFRB"
                     /codon_start=1
BASE COUNT     1195 a   1676 c   1530 g   1169 t
ORIGIN      Chromosome 5q31-q32.
        1 ggcccctcag ccctgctgcc cagcacgagc ctgtgctcgc cctgcccaac gcagacagcc
       61 agacccaggg cggcccctct ggcggctctg ctcctcccga aggatgcttg gggagtgagg
      121 cgaagctggg cgctcctctc ccctacagca gcccccttcc tccatccctc tgttctcctg
      181 agccttcagg agcctgcacc agtcctgcct gtccttctac tcagctgtta cccactctgg
      241 gaccagcagt ctttctgata actgggagag ggcagtaagg aggacttcct ggagggggtg
      301 actgtccaga gcctggaact gtgcccacac cagaagccat cagcagcaag gacaccatgc
      361 ggcttccggg tgcgatgcca gctctggccc tcaaaggcga gctgctgttg ctgtctctcc
      421 tgttacttct ggaaccacag atctctcagg gcctggtcgt cacacccccg gggccagagc
      481 ttgtcctcaa tgtctccagc accttcgttc tgacctgctc gggttcagct ccggtggtgt
      541 gggaacggat gtcccaggag cccccacagg aaatggccaa ggcccaggat ggcaccttct
      601 ccagcgtgct cacactgacc aacctcactg ggctagacac gggagaatac ttttgcaccc
      661 acaatgactc ccgtggactg gagaccgatg agcggaaacg gctctacatc tttgtgccag
      721 atcccaccgt gggcttcctc cctaatgatg ccgaggaact attcatcttt ctcacggaaa
      781 taactgagat caccattcca tgccgagtaa cagacccaca gctggtggtg acactgcacg
      841 agaagaaagg ggacgttgca ctgcctgtcc cctatgatca ccaacgtggc ttttctggta
      901 tctttgagga cagaagctac atctgcaaaa ccaccattgg ggacagggag gtggattctg
      961 atgcctacta tgtctacaga ctccaggtgt catccatcaa cgtctctgtg aacgcagtgc
     1021 agactgtggt ccgccagggt gagaacatca ccctcatgtg cattgtgatc gggaatgagg
     1081 tggtcaactt cgagtggaca tacccccgca aagaaagtgg gcggctggtg gagccggtga
     1141 ctgacttcct cttggatatg ccttaccaca tccgctccat cctgcacatc cccagtgccg
     1201 agttagaaga ctcggggacc tacacctgca atgtgacgga gagtgtgaat gaccatcagg
     1261 atgaaaaggc catcaacatc accgtggttg agagcggcta cgtgcggctc ctgggagagg
     1321 tgggcacact acaatttgct gagctgcatc ggagccggac actgcaggta gtgttcgagg
     1381 cctacccacc gcccactgtc ctgtggttca aagacaaccg caccctgggc gactccagcg
     1441 ctggcgaaat cgccctgtcc acgcgcaacg tgtcggagac ccggtatgtg tcagagctga
     1501 cactggttcg cgtgaaggtg gcagaggctg gccactacac catgcgggcc ttccatgagg
     1561 atgctgaggt ccagctctcc ttccagctac agatcaatgt ccctgtccga gtgctggagc
     1621 taagtgagag ccaccctgac agtggggaac agacagtccg ctgtcgtggc cggggcatgc
     1681 cccagccgaa catcatctgg tctgcctgca gagacctcaa aaggtgtcca cgtgagctgc
     1741 cgcccacgct gctggggaac agttccgaag aggagagcca gctggagact aacgtgacgt
     1801 actgggagga ggagcaggag tttgaggtgg tgagcacact gcgtctgcag cacgtggatc
     1861 ggccactgtc ggtgcgctgc acgctgcgca acgctgtggg ccaggacacg caggaggtca
     1921 tcgtggtgcc acactccttg ccctttaagg tggtggtgat ctcagccatc ctggccctgg
     1981 tggtgctcac catcatctcc cttatcatcc tcatcatgct ttggcagaag aagccacgtt
     2041 acgagatccg atggaaggtg attgagtctg tgagctctga cggccatgag tacatctacg
     2101 tggaccccat gcagctgccc tatgactcca cgtgggagct gccgcgggac cagcttgtgc
     2161 tgggacgcac cctcggctct ggggcctttg ggcaggtggt ggaggccacg gctcatggcc
     2221 tgagccattc tcaggccacg atgaaagtgg ccgtcaagat gcttaaatcc acagcccgca
     2281 gcagtgagaa gcaagccctt atgtcggagc tgaagatcat gagtcacctt gggccccacc
     2341 tgaacgtggt caacctgttg ggggcctgca ccaaaggagg acccatctat atcatcactg
     2401 agtactgccg ctacggagac ctggtggact acctgcaccg caacaaacac accttcctgc
     2461 agcaccactc cgacaagcgc cgcccgccca gcgcggagct ctacagcaat gctctgcccg
     2521 ttgggctccc cctgcccagc catgtgtcct tgaccgggga gagcgacggt ggctacatgg
     2581 acatgagcaa ggacgagtcg gtggactatg tgcccatgct ggacatgaaa ggagacgtca
     2641 aatatgcaga catcgagtcc tccaactaca tggcccctta cgataactac gttccctctg
     2701 cccctgagag gacctgccga gcaactttga tcaacgagtc tccagtgcta agctacatgg
     2761 acctcgtggg cttcagctac caggtggcca atggcatgga gtttctggcc tccaagaact
     2821 gcgtccacag agacctggcg gctaggaacg tgctcatctg tgaaggcaag ctggtcaaga
     2881 tctgtgactt tggcctggct cgagacatca tgcgggactc gaattacatc tccaaaggca
     2941 gcaccttttt gcctttaaag tggatggctc cggagagcat cttcaacagc ctctacacca
     3001 ccctgagcga cgtgtggtcc ttcgggatcc tgctctggga gatcttcacc ttgggtggca
     3061 ccccttaccc agagctgccc atgaacgagc agttctacaa tgccatcaaa cggggttacc
     3121 gcatggccca gcctgcccat gcctccgacg agatctatga gatcatgcag aagtgctggg
     3181 aagagaagtt tgagattcgg ccccccttct cccagctggt gctgcttctc gagagactgt
     3241 tgggcgaagg ttacaaaaag aagtaccagc aggtggatga ggagtttctg aggagtgacc
     3301 acccagccat ccttcggtcc caggcccgct tgcctgggtt ccatggcctc cgatctcccc
     3361 tggacaccag ctccgtcctc tatactgccg tgcagcccaa tgagggtgac aacgactata
     3421 tcatccccct gcctgacccc aaacccgagg ttgctgacga gggcccactg gagggttccc
     3481 ccagcctagc cagctccacc ctgaatgaag tcaacacctc ctcaaccatc tcctgtgaca
     3541 gccccctgga gccccaggac gaaccagagc cagagcccca gcttgagctc caggtggagc
     3601 cggagccaga gctggaacag ttgccggatt cggggtgccc tgcgcctcgg gcggaagcag
     3661 aggatagctt cctgtagggg gctggcccct accctgccct gcctgaagct ccccccctgc
     3721 cagcacccag catctcctgg cctggcctga ccgggcttcc tgtcagccag gctgccctta
     3781 tcagctgtcc ccttctggaa gctttctgct cctgacgtgt tgtgccccaa accctggggc
     3841 tggcttagga ggcaagaaaa ctgcaggggc cgtgaccagc cctctgcctc cagggaggcc
     3901 aactgactct gagccagggt tcccccaggg aactcagttt tcccatatgt aagatgggaa
     3961 agttaggctt gatgacccag aatctaggat tctctccctg gctgacaggt ggggagaccg
     4021 aatccctccc tgggaagatt cttggagtta ctgaggtggt aaattaactt ttttctgttc
     4081 agccagctac ccctcaagga atcatagctc tctcctcgca ctttttatcc acccaggagc
     4141 tagggaagag accctagcct ccctggctgc tggctgagct agggcctagc cttgagcagt
     4201 gttgcctcat ccagaagaaa gccagtctcc tccctatgat gccagtccct gcgttccctg
     4261 gcccgagctg gtctggggcc attaggcagc ctaattaatg ctggaggctg agccaagtac
     4321 aggacacccc cagcctgcag cccttgccca gggcacttgg agcacacgca gccatagcaa
     4381 gtgcctgtgt ccctgtcctt caggcccatc agtcctgggg ctttttcttt atcaccctca
     4441 gtcttaatcc atccaccaga gtctagaagg ccagacgggc cccgcatctg tgatgagaat
     4501 gtaaatgtgc cagtgtggag tggccacgtg tgtgtgccag tatatggccc tggctctgca
     4561 ttggacctgc tatgaggctt tggaggaatc cctcaccctc tctgggcctc agtttcccct
     4621 tcaaaaaatg aataagtcgg acttattaac tctgagtgcc ttgccagcac taacattcta
     4681 gagtattcca ggtggttgca catttgtcca gatgaagcaa ggccatatac cctaaacttc
     4741 catcctgggg gtcagctggg ctcctgggag attccagatc acacatcaca ctctggggac
     4801 tcaggaacca tgccccttcc ccaggccccc agcaagtctc aagaacacag ctgcacaggc
     4861 cttgacttag agtgacagcc ggtgtcctgg aaagccccaa gcagctgccc cagggacatg
     4921 ggaagaccac gggacctctt tcactaccca cgatgacctc cgggggtatc ctgggcaaaa
     4981 gggacaaaga gggcaaatga gatcacctcc tgcagcccac cactccagca cctgtgccga
     5041 ggtctgcgtc gaagacagaa tggacagtga ggacagttat gtcttgtaaa agacaagaag
     5101 cttcagatgg taccccaaga aggatgtgag aggtggccgc ttggagtttg cccctcaccc
     5161 accagctgcc ccatccctga ggcagcgctc catgggggta tggttttgtc actgcccaga
     5221 cctagcagtg acatctcatt gtccccagcc cagtgggcat tggaggtgcc aggggagtca
     5281 gggttgtagc caagacgccc ccgcacgggg agggttggga agggggtgca ggaagctcaa
     5341 cccctctggg caccaaccct gcattgcagg ttggcacctt acttccctgg gatccccaga
     5401 gttggtccaa ggagggagag tgggttctca atacggtacc aaagatataa tcacctaggt
     5461 ttacaaatat ttttaggact cacgttaact cacatttata cagcagaaat gctattttgt
     5521 atgctgttaa gtttttctat ctgtgtactt ttttttaagg gaaagatttt
//