From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Dictyostelium discoideum phosphotyrosine phosphatase (PTP1) gene,
Date: 22 Dec 92 22:50:56 GMT
Distribution: bionet
Checksum: 64866 5

LOCUS       DDIPTP1A     1749 bp ds-DNA             PLN       30-NOV-1992
DEFINITION  Dictyostelium discoideum phosphotyrosine phosphatase (PTP1) gene,
            complete cds.
ACCESSION   L07125
KEYWORDS    phosphotyrosine phosphatase.
SOURCE      Dictyostelium discoideum (strain AX-3) (library: 16 hr lambda ZAP
            of G.Schnitzler) slug DNA.
  ORGANISM  Dictyostelium discoideum
            Eukaryota; Fungi; Myxomycota; Acrasiomycetes; Dictyosteliales;
            Dictyosteliaceae.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Howard,P.K., Sefton,B.M. and Firtel,R.A.
  TITLE     Analysis of a spatially regulated phosphotyrosine phosphatase
            identifies tyrosine phosphorylation as a key regulatory pathway in
            Dictyostelium
  JOURNAL   Cell 71, 637-647 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            <1..306
                     /number=1
                     /gene="PTP1"
     intron          307..406
                     /number=1
                     /gene="PTP1"
     exon            407..574
                     /number=2
                     /gene="PTP1"
     misc_feature    450..1590
                     /function="PTP conserved catalytic domain"
     intron          575..657
                     /number=2
                     /gene="PTP1"
     exon            658..>1749
                     /number=3
                     /gene="PTP1"
     misc_feature    1165..1458
                     /note="region of insertion in PTP conserved domain"
     CDS             join(1..306,407..574,658..1749)
                     /gene="PTP1"
                     /product="protein tyrosine phosphatase"
                     /codon_start=1
                     /translation="MGSVESSNQMNGSIENKTNKIDISVLRPLPTRSNSSISLSSSSH
                     SSFSRMGSLGSLPTNSGSSSPYYNNSSFDLVDEERIKSSIYNLKNHIKCIHKIKEEFR
                     LLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA
                     YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQF
                     SIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIP
                     DHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYF
                     KQLDATPIDQVVDPFTHLPITEYQSDNLDLKGLGYHFKSSIYNSNGINNNNNNNLNNN
                     NNINNNSNGSNNTPQTEPNNEEDDDDAAESTKYAIMDKYNSRIDFNLFSIVLKLREQR
                     PGMVQQLEQYLFCYKTILDEIYHRLNCKLGFSLPHVNNINNYNNYSNTTTTTTSSLAS
                     TTIIHPSTNSKLN"
BASE COUNT      697 a    228 c    241 g    583 t
ORIGIN      
        1 atgggatcag ttgaaagttc aaatcaaatg aatggatcca ttgaaaataa aacaaataag
       61 attgatatta gtgtattgag accattacca actagaagca atagctcaat atcattaagt
      121 tcctcttctc atagttcatt cagtagaatg ggatcactag gttcattacc aacaaattct
      181 ggttcttctt caccctatta caataatagt tcatttgatc ttgttgatga agaaagaatt
      241 aaatcttcaa tttataattt aaaaaatcat attaaatgta ttcataaaat taaagaagaa
      301 tttagagtaa gttttaattt ttttaaaaaa aaaaaaaaaa gaaaacaaaa tgacttactt
      361 tatttatttt tattttattt tcattttttt aaaaaaaaaa aaatagttat tggaagaatc
      421 tgttggacca agtgaaacca gtgaaggtga taaaaaacat aacacatcaa agaatagata
      481 tactaatatt ttaccagtta atcatacaag agtacaatta aaaaagattc aagataaaga
      541 aggttcagat tatattaatg ctaattatat tgatgtaagt atatatttaa ttaatttttt
      601 ttaataatat aattctaatt tttttcttat tttttatttt ttattaataa taaaaaggga
      661 gcatacccaa aacaatttat ttgtacacaa ggaccattac caaatacaat tgctgatttt
      721 tggagaatgg tatgggaaaa tcgatgtcgt attattgtta tgctttcaag agagtctgaa
      781 aactgtagaa taaaatgtga tagatattgg ccagaacaaa ttggaggtga acaattttca
      841 atatatggta atggtaatga agtatttggc acatacagtg tcgaattggt tgaggttatc
      901 caagatccag agagagagat aatcacaaga aacattagac ttacatttga gggtgagaca
      961 agagatatca ctcaatatca atatgaaggt tggccagatc ataacatccc agatcacact
     1021 caaccattcc gtcagttgtt acatagtatc acaaatcgtc aaaatcaaat cataccatca
     1081 tcagatagaa atgttccaat catcgttcat tgtagtgcag gagttggtag aaccggcacc
     1141 ttttgtacag ccgtcattat gatgaaaaag ttggaccatt actttaaaca attggatgct
     1201 actccaattg atcaagtcgt tgatcctttc actcatttac caatcactga atatcaaagt
     1261 gataatttag atttaaaagg acttggttat cattttaaat cttcaattta taatagtaat
     1321 ggtataaata ataataataa taataattta aataataata ataatattaa taataattca
     1381 aatggttcaa ataatacgcc acaaactgaa ccaaataatg aggaagatga tgatgacgca
     1441 gcagaatcga ctaaatatgc aataatggat aaatataata gtagaatcga ttttaattta
     1501 ttttcaatag ttttgaaact tagagagcaa cgtcctggaa tggttcaaca attagaacaa
     1561 tatctatttt gttataaaac aattttagac gaaatttatc atagattaaa ttgtaaatta
     1621 ggtttttctt taccacatgt taataatatc aataattata ataattatag taatactact
     1681 accaccacta cttcttcttt agcctcaact acaataattc atccatctac aaatagtaaa
     1741 ttaaattaa
//