HDTenEightyP/NetNews huggingface dataset:
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: BIOSCI WAIS server operational again
Keywords: BIOSCI WAIS biosci.src biology-journals-contents.src
Date: 9 Oct 92 22:57:30 GMT
Distribution: bionet
Organization: BIOSCI International Newsgroups for Biology


I am pleased to announce that the BIOSCI WAIS server is operational
again, thanks to Kenton Hoover's efforts this week, and a new feature
has been added - daily updates to the complete BIOSCI WAIS source
(biosci.src) and to the journal contents source
(biology-journals-contents.src).  This can be done in a more timely
fashion on net.bio.net now that we no longer have the added CPU load
from all of the database searches that were performed in the past on
genbank.bio.net.

Please note that if you have saved settings for the two WAIS sources on
your local machine, e.g., for your Mac WAIS client, the saved source
folders probably still point to genbank.bio.net (134.172.3.160).

*** USING THESE SOURCE SETTINGS IN YOUR WAIS QUERY WILL NOT WORK!! ***

We have sent updated information for both sources to the WAIS
directory of servers, but they have not been incorporated as of this
writing.  Either you can wait and retrieve an updated biosci.src and
biology-journals-contents.src from the directory-of-servers.src (query
for "BIOSCI" using directory-of-servers.src) or you can manually
change the host number in your own source file.  The address for
net.bio.net that should be entered is 134.172.2.69.  The port value
remains at 210.

On the Mac these options can be accessed by first clicking on the
appropriate source in the Source folder and then clicking on the
Contact box MacTCP option.  This brings up the address and port dialog
box.  Simply change the address setting as indicated above, save
the changes to the .src file, and then you should be ready to fly.

The BIOSCI FTP area will be reestablished soon, and the complete
newsgroup archive will be made available shortly thereafter.

***NET.BIO.NET WILL BE OFF-LINE THIS EVENING WHILE WORK ON THIS
   COMMENCES ***.

Kenton is also making progress on bringing the genbank.updates
newsgroup back into operation.

For those who are unfamiliar with WAIS, the software provides a means
of searching through the BIOSCI archives for any text of interest.
This is especially useful if you are trying to find postings about
experimental methods or recent articles on a certain topic using the
biology-journals source.  To use WAIS you must have a local machine
that has a connection to the Internet, e.g., a Mac or PC with a local
area network connection that ties into your campus'/institution's
route to the Internet.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: kristoff@NET.BIO.NET (David Kristofferson)
Newsgroups: bionet.announce
Subject: BIOSCI Newsgroups - Changes
Date: 8 Oct 92 01:16:33 GMT
Distribution: bionet



		       *** IMPORTANT NOTICE ***


The BIOSCI node at GenBank/IntelliGenetics has been
changed from the computer genbank.bio.net to net.bio.net.
                          ^^^^^^^^^^^^^^^    ^^^^^^^^^^^

Kenton Hoover and I will continue to run the BIOSCI node at
IntelliGenetics in the post-GenBank period.  Alan Bleasby, Steve
Marshall, Paul Griffiths and David Hines at SERC Daresbury Laboratory
will continue to serve their BIOSCI user community.

Messages sent to the old genbank.bio.net computer will be
automatically received by net.bio.net, so this transition should occur
transparently to our users.  The October version of the info sheet
uses the new net.bio.net addresses however.  All posting and other
BIOSCI addresses are changed from xxxxxx@genbank.bio.net to
xxxxxx@net.bio.net.

To repeat, the genbank.bio.net addresses will continue to function,
but people should begin adjusting their habits to utilize the new
hostname net.bio.net.  "Old hands" will recognize net.bio.net from
BIONET days; the address has the virtue of being reachable from any
site in the world regardless of the ordering convention used for host
names.

The BIOSCI/bionet WAIS sources biosci.src and
biology-journals-contents.src are temporarily out of commission but
will be back on-line soon.

The same is true for the bionet.molbio.genbank.updates newsgroup.  The
data feed will be resumed shortly from NCBI. 

One new newsgroup has been added to discuss issues pertaining to women
professionals in biology.  The mailing list name is WOMENBIO and
newsgroup name is bionet.women-in-bio.  The discussion leader is
Cassandra Smith (cls@buenga.bu.edu) who will be posting an
introductory announcement fairly soon from Boston University.

David Kristofferson
BIOSCI/bionet Manager
From: GSBS1032%UTSPH.THENET@LIB.TMC.EDU
Newsgroups: bionet.neuroscience
Subject: Re: Neurotransmitter questions
Date: 11 Oct 92 04:00:11 GMT
Distribution: bionet


	Hello!

	Could anybody recommend a text on serotonergic pharmacology
that covers the current understanding of 5-HT receptor subtypes, their
agonists and antagonists, etc.? I have been out of the field for several
years, and need an update.

gsbs1032@utsph.bitnet
Newsgroups: bionet.neuroscience
From: rs69@cunixb.cc.columbia.edu (Rong Shen)
Subject: breakfast and brain health
Organization: Columbia University
Date: Mon, 12 Oct 1992 23:08:59 GMT

Hi Everyone:

	A while ago someone posted an article about losing brain
capacity while working in labs. I thought it was a joke until I heard
from my mother yesterday that not eating breakfast would really make
people stupid over a long period of time.

	This is the story. A reporter for a newspaper wrote that a
doctor in Japan did some clinical research on the corelation between
productivity and breakfast; he found that all the students in medical
school who did not do well academically and all the graduates who had
not received licenses for medical practice did not have the habit of
eating breakfast. Since neurons are unable to metabolize proteins or
other cell constituents, once the glucose concentration in the blood
falls, the brain can not function to its full capacity.

	Well, I also do not have the habit of eating breakfast. After
dinner, I usually study till early morning WITHOUT eating anything in
the meantim; in the morning, I am so sleepy and so hungry that I do
not have the strength to get up, and so I miss breakfasts perpetually.
No wonder my mind is not as sharp as it was in high school, when my
mother made breakfasts, and no wonder I have become so skinny.

	I think if I adopt a healthier habit, I can restore my mind to
its former glory. But the guy who posted the article about losing
neurons in the lab instilled a vast fear in me: I am afraid that,
having starved myself for four semesters, I have lost so many neurons
that the dullness of my mind has become permanent, irrevokable by any
healthy habits.

	All comments and suggestions are welcomed. Thanks in advance.

------
rs69@cunixb.cc.columbia.edu

	(If I am posting this article to the wrong group, I will
cancel it.)
Newsgroups: bionet.neuroscience,alt.drugs
From: lordnose@well.sf.ca.us (Lord Nose!)
Subject: Xochi Stack 1.0 (MDMA/LSD/XOCHIPILLI)
Organization: Whole Earth 'Lectronic Link
Date: Thu, 8 Oct 1992 13:55:03 GMT

Xochi Stack 1.0 (BIONET.NEUROSCIENCE ANNOUNCEMENT)
---------------

Xochi Stack 1.0 is a HyperCard stack on the psychedelics that runs 
on the Macintosh computer. Profiled in this educational stack are 
MDMA and LSD, as well as an Aztec deity devoted to traditional 
sacred plants of Mexico.  You can find a copy of the stack, in five 
pieces, in <comp.binaries.mac>. Feel free to copy the software for 
friends, put on FTP sites, BBSs, et cetera, but you do not have the 
right to sell copies of this copyrighted material. If you can help 
put the stack out there, on FTP sites or whatever, please contact us!
A version for Windows is in the works...

Xochi Stack 1.0 is a public service message from LordNose!, and 
(c) 1992 LordNose! Donations of 400K diskettes greatly appreciated.

We're not advocating illegal drug use, just giving some factual
grounding to the population that already uses these compounds and
to counter some of the poisonous propaganda out there.  Most of the
information circulating is erroneous, emphasizing either the simple
hedonistic aspects of particular substances, or warning of the 
ominous consequences of their use.

	lordnose@well.sf.ca.us

"THE ADVANCEMENT AND DIFFUSION OF KNOWLEDGE IS THE ONLY 
 GUARDIAN OF TRUE LIBERTY." -- James Madison, 4th US President
From: wu@fred.med.yale.edu
Newsgroups: bionet.neuroscience
Subject: Rewiring.
Date: 12 Oct 92 21:19:59 GMT
Organization: Marine Biological Laboratory, Woods Hole


  Hi netters,
  Can any one give me an example of a group of neurons rewiring into circuits for different functions? 
JY Wu
Xref: sparky bionet.neuroscience:459 alt.drugs:17009
From: jwfost@phoenix.Princeton.EDU (Joshua W. Fost)
Newsgroups: bionet.neuroscience,alt.drugs
Subject: Re: Neurotransmitter questions
Date: 13 Oct 92 20:56:48 GMT
Organization: Princeton University
Originator: news@nimaster

In article <1aqqt4INNi4c@calvin.usc.edu> alves@calvin.usc.edu (William Alves) writes:
>First, this whole neurotransmitter business. As I see it, there are only
>two possible effects a neurotransmitter can have on a neuron - it can
>inhibit or excite the cell. Then doesn't it seem logical that there would
>be only two types of neurotransmitters, instead of the pharmacopeia that
>has been discovered? What is the difference between inhibition from one
>neurotransmitter and another?
>
>Second, the non-technical sources I have read have made a big deal out of
>the chemical similarities between certain hallucinogens (LSD for example)
>and certain neurotransmitters (serotonin for example). Yet is simple 
>mimickry behind all of the drug's effects? If that is so, why do different
>serotonin-like drugs have wildly different effects, and others have none
>at all?

First of all, there are *not* only two effects NTs can have on cells.
Many receptors are coupled to so-called 2nd messengers which can 
produce all kinds of funky effects. For example, GABA, perhaps the
most common inhibitory NT in the CNS, has a class of receptors which
produce only small inhibitory PSPs (post-synaptic potentials) but 
which are coupled to several other proteins which can modulate the
amount of an intracellular protein called adenylate cyclase. It turns
out that adenylate cyclase can then go on to change the amount of
transmitter that is released from that cell, and this transmitter need
NOT be GABA. 2nd messengers can also go to the nucleus of the cell
and change gene readout, which can, in principle, do absolutely
anything. 
	Furthermore, all PSPs are not created equal. That is, the
time course and magnitude of a given IPSP, for example, can vary a lot,
and such variation can really affect how signals are integrated in a
given post-synaptic neuron. How do you vary the time course and
magnitude of a PSP? Well, you do it by using a different receptor.
	So, there are all kinds of weird and subtle things that come out
of the interaction between NT and receptor. Who knows WHY the brain
needs all these mechanisms. (Well, one could speculate.) The fact is,
if you can think of ten ways in which the brain might be doing
something, it is doing it in all ten, plus ten that you haven't thought
of yet.
Newsgroups: bionet.neuroscience
From: rowe@engin.umich.edu (Steven Rowe)
Subject: Address correction
Date: Thu, 15 Oct 92 14:18:46 EDT
Organization: The University of Michigan, Ann Arbor
Followup-To: Cell Assembly reference request 

Distribution: bionet.neuroscience
Organization: University of Michigan Engineering, Ann Arbor
Keywords: 
Hi again, and sorry to clutter the net.  I recently posted a request
for information for biological cell assemblies and evidence of fatigue
in cortical neurons.  I have received only one response, and that was
to an address other than the one specified.  I humbly re-submit my
request and ask you to e-mail responses to rowe@engin.umich.edu.
Thanks.
-- 
     These folks who don't believe in evolution
are the ones who look the most like they could use some.

                                   -Frank Allison
From: inunn@hpb.hwc.ca
Newsgroups: bionet.neuroscience
Subject: Re: WELCOME to rec.neurosci.funny!
Date: 16 Oct 92 08:54:12 EDT
Organization: Health and Welfare, Canada

Perhaps this group could become moderated to filter out the pop culture noise.
From: wu@fred.med.yale.edu
Newsgroups: bionet.neuroscience
Subject: Ask for recruiters
Date: 12 Oct 92 20:43:11 GMT
Organization: Marine Biological Laboratory, Woods Hole

Please recommend a few recruiters for neuroscientists. Many thanks.
Jian-young Wu.
Newsgroups: bionet.neuroscience,sci.med,sci.bio,alt.drugs
From: stone@cunixb.cc.columbia.edu (Glenn Stone)
Subject: Re: Affecting hallucinations via other drugs
Reply-To: stone@cunixb.cc.columbia.edu (Glenn Stone)
Organization: Columbia University
Date: Sat, 10 Oct 1992 03:38:18 GMT

In article <MepTpxS00VpE4BDVQi@andrew.cmu.edu> de0t+@andrew.cmu.edu (Daniel S. Efran) writes:
>Excerpts from netnews.alt.drugs: 9-Oct-92 Affecting hallucinations vi..
>Allen Smith@yang.earlham (1371)
>
>>         I started wondering what the effects of combining hallucinogens
>> and pleasurable drugs would be. In other words, could one influence the
>> course of the "trip" by taking other drugs along with it?

Well of course the methylated amphetamines like DOM ("STP") and MDA
automatically give you two, two, two highs in one -- mood elevation
plus trippiness.  MDA was fabulously popular as a recreational drug
in many places back then.

I know some people who accidentally discovered that the combination of
MDA plus nitrous oxide was intensely euphoric.

-------------------------------------------------------------------------
  Glenn Davis Stone                                BITNET: stone@cunixf
  Columbia University            INTERNET: stone@cunixb.cc.columbia.edu
-------------------------------------------------------------------------
Newsgroups: bionet.neuroscience,sci.med,alt.sex,sci.skeptic
From: pinelr@marcus.its.rpi.edu (Rob Pinelli)
Subject: Re: Cerebro-spinal fluid in semen? (Was Re: breakfast ...)
Organization: Rensselaer Polytechnic Institute, Troy, NY
Date: Fri, 16 Oct 1992 00:54:38 GMT

In article <crystal.719172200@glia> crystal@glia.biostr.washington.edu (Crystal) writes:
>In <1992Oct15.052050.10038@cssc-syd.tansu.com.au> pete@cssc-syd.tansu.com.au (Peter Alexander Merel) writes:
>
>>I don't know if this is so, but I have a related question. I've begun 
>>practicing the Taoist semen retention techniques mentioned in the alt.sex
>>FAQ, and just as described there I have noticed a fantastic increase in
>>mental alertness and physical stamina. 
>
>>There are two rationales proposed in the Taoist literature to explain the
>>phenomenon, and I'm not sure that I buy either of them. The first is that
>>semen is 20% cerebro-spinal fluid, so if you ejaculate it your brain and
>>spine kind of sag, and that's why males want to go to sleep after ejaculation.
>
>I'm not a biologist, but this has *got* to be the strangest crock I have 
>*ever* heard!  
>
>Males (and females, who do *not* produce semen, BTW ;>) want to fall asleep
>afterwards simply from the sheer exhaustion that happens from the typical
>bedroom romp.  Sex is a workout, if you're doing it right. :>  Haven't
>you ever wanted to fall asleep after OTHER physical exertion?  The fact that
>you don't *usually* fall asleep after jogging or whatever has less to do
>with the exhaustion factor than it does being in a nice comfortable bed with
>a loved one in your arms.  It's more psychological than physiological.  

   Actually, the way I heard it from my psych professor, the orgasm is a 
function of the parasympathetic branch of the nervous system.  That's the
branch that serves to inhibit all of the excitory effects of the sympathetic
nervous system.  When you have sex, your heartrate increases, your breathing 
increases, and a lot of other changes take place all controlled by the
sympathetic branch.  When you have an orgasm, the parasympathetic branch
takes over, flushing your vasocongested areas, slowing your heart rate to 
normal, slowing your breathing, constricting your blood vessels, etc.  This
global "slowing down" mechanism is why you feel sleepy after having an orgasm.
Basically, everything in your nervous system is in a state of being brought
down from a higher level of activity.  That's not to say that you aren't
exhausted from the activity too!  In fact you should be! (If you did it 
right! :)


-- 
  |||   | Rob Pinelli    |5\ "The future is not set.  There is no fate but what 
 / | \  | pinelr@rpi.edu |18\ we make for ourselves..."   -Terminator 2
Atari ST| 203 North Hall |276\ "I don't patronize bunny rabbits!"   "What's 
 Mega 2 | Troy, NY 12180 |7080\ your damage?"  "It'll be very!"  -Heathers
From: stenberg@klaava.Helsinki.FI (Dag Stenberg)
Newsgroups: bionet.neuroscience
Subject: Re: Neurotransmitter questions
Date: 11 Oct 92 21:26:54 GMT
Distribution: bionet
Organization: University of Helsinki

GSBS1032%UTSPH.THENET@LIB.TMC.EDU writes:
: 	Could anybody recommend a text on serotonergic pharmacology
: that covers the current understanding of 5-HT receptor subtypes, their
: agonists and antagonists, etc.? I have been out of the field for several
: years, and need an update.
: 
For an update on the understanding of 5-HT receptor subtypes, I can
recommend
Jacobs BL, Azmitia EC
Structure and function of the brain serotonin system.
Physiol Rev 1992 Jan;72(1):165-229

It is not specifically pharmacology; you get anatomy and physiology in
the bargain. But I think it is quite good.

Dag Stenberg, MD PhD
Dept. Physiology
Univ. Helsinki
Newsgroups: bionet.neuroscience
From: olds@helix.nih.gov (James Olds)
Subject: Re: Neurosci. Grad. Programs
Organization: National Institutes of Health, Bethesda
Distribution: usa 
Date: Fri, 16 Oct 1992 20:20:11 GMT

In article <1992Oct16.165052.23986@zip.eecs.umich.edu> cdhohnke@quip.eecs.umich.edu (Carsten Hohnke) writes:
>While my assumption is that this topic has come up before, I was unable to
>find a FAQ posting for this newsgroup.  So here goes:
>
>What is the opinion out there on where the quality neurosci. grad. programs
>are?  I'd like to exclude cellular and molecular neurobiology from
>discussion.
>
>A separate, but related question:  Are there people out there, other than
>at the Neurosciences Institute in La Jolla, approaching problems in   
>neuroscience from within the context of Gerald Edelman's TNGS?
>
>Thanks in advance.  

Carsten...
I see you are from UofM which is where I got my degree. All in all
the Neuroscience PHD program at Michigan was an excellent experience...
and it directly led to me obtaining a tenure track position at NIH
without a postdoc. On the other hand I mainly do cellular neurobioloogy...
which you seem to want to exclude. Specifically I am into imaging changes
in protein kinase C within living cells.

Our laboratory at NIH is very interested in some of the same issues as
Edelmann, but I think we disagree with some of his assumptions at a 
fundemental level. If you are intersted in some reprints, contact me
directly by e-mail.
Cheers,

--
****************************************************************************
* James L. Olds Ph.D.                 Neural Systems Section               *
* domain: olds@helix.nih.gov           NINDS, NIH, Bethesda, MD. 20892 USA *
****************************************************************************
From: ringo@craft.camp.clarkson.edu (Ringo)
Newsgroups: bionet.neuroscience
Subject: Neurotoxin Question
Date: 7 Oct 92 17:00:40 GMT
Distribution: bionet
Organization: Clarkson University

Okay, this will probably generate a few strange looks, but I'm used
to that.....

Can someone tell me the name of a neurotoxin that specifically comes
from a frog? With a slight blush, thank you for your time.

--John Rescigno
Dept. of Psychology
Clarkson University
Nowhere, NY
From: pck@castle.ed.ac.uk (P C Knox)
Newsgroups: bionet.neuroscience
Subject: Re: Hottest topic
Date: 8 Oct 92 10:51:17 GMT
Distribution: bionet
Organization: Edinburgh University

GREENSPA@SNYSYRV1.bitnet writes:


>  It seems to me that the current fad in neuroscience is nitric oxide
>(just say NO), which does so much that I wonder if we need neurotransmitters.

OK then ...... NO!

This may be the current fad, but the hottest topic (see earlier posting)
has been on the boil for at least a century. But we might be about to
settle it.

Paul Knox
From: TOMLINSON@NEUROPHYS.WISC.EDU (Ward Tomlinson)
Newsgroups: bionet.neuroscience
Subject: unsubscribe tomlinson@neurophys.wisc.edu
Date: 9 Oct 92 21:32:00 GMT
Distribution: bionet

please unsubscribe tomlinson@neurophys.wisc.edu
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.neuroscience
Subject: Purpose of bionet.neuroscience
Date: 13 Oct 92 19:14:57 GMT
Organization: BIOSCI International Newsgroups for Biology

I have had some scientists cancel their subscriptions to this
newsgroup lately because of the fact that postings were diverging from
the intent of the newsgroup:

NEUROSCIENCE               bionet.neuroscience

Discussions about research in the neurosciences

Please make sure that all postings conform to the above agenda.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: Ruud Hovius
Newsgroups: bionet.neuroscience
Subject: quipazine, where to buy ?
Date: 15 Oct 92 16:59:11 GMT
Reply-To: hovius@icphp1
Followup-To: bio.sci
Organization: EPFL

hello,

I am looking for the compound quipazine, a drug targetted at the serotonine
receptor. The problem is that the companies that make this compound, as far as
I know, do not make this product anymore !

Please help me !!

Thanks,  Ruud

e-mail : hovius@icphp1.epfl.ch
FAX : +41-21-6934111 
Newsgroups: bionet.neuroscience
From: mmurrain@hamp.hampshire.edu
Subject: re: rewiring
Organization: Hampshire College
Date: Tue, 13 Oct 1992 20:55:39 GMT

I'm not exactly sure what you mean by rewire, but if you mean that the same
circuit of neurons can have different functions, chenck out lobster
stomatogastric ganglion, and ingestion egestion in crab?? these are vague
recollections, maybe someone out there has solid refs.

mmurrain@hamp.hampshire.edu
From: pck@castle.ed.ac.uk (P C Knox)
Newsgroups: bionet.neuroscience
Subject: Re: hottest topic
Date: 7 Oct 92 08:35:52 GMT
Distribution: bionet
Organization: Edinburgh University

tsau@FRED.MED.YALE.EDU writes:

>Hello netters,
>  What is the hottest topic on neuroscience?
>  T.Y.
Well, I don't know about "on" Neuroscience, but IMHO in Neuroscience it
whether extra-ocular muscle afferent signals really are involved in
oculomotor control! Mind you, there are probably as many different
opinions as to the hottest topic as there are neuroscientists!

Paul Knox.
From: cdhohnke@quip.eecs.umich.edu (Carsten Hohnke)
Newsgroups: bionet.neuroscience
Subject: Re: Neurosci. Grad. Programs
Date: 16 Oct 92 16:50:52 GMT
Distribution: usa
Organization: University of Michigan EECS Dept., Ann Arbor

While my assumption is that this topic has come up before, I was unable to
find a FAQ posting for this newsgroup.  So here goes:

What is the opinion out there on where the quality neurosci. grad. programs
are?  I'd like to exclude cellular and molecular neurobiology from
discussion.

A separate, but related question:  Are there people out there, other than
at the Neurosciences Institute in La Jolla, approaching problems in   
neuroscience from within the context of Gerald Edelman's TNGS?

Thanks in advance.  
Newsgroups: bionet.neuroscience