From: u8951608@csdvax.csd.unsw.edu.au
Newsgroups: alt.psychoactives
Subject: Re: DMT, 5MeoDMT, and other isomers
Date: 8 Nov 92 08:45:43 GMT
Organization: University of New South Wales

In article <1992Nov3.020027.12143@muddcs.claremont.edu>, ileicht@jarthur.claremont.edu (Spiff) writes:
> 
To what everyone else has said about DMT, 5-Me-O-DMT, and DET I will
add a few comments off the top of my head. I am most familiar with the 
first, having heard numerous reports.

Dose:
DMT: 30-60 mg
DET about the same
5-Me-O DMT 5-15 mg
I imagine they all taste extremely bad and are filthy to smoke. 
5-Me-O DMT would be vastly superior in this regard since the
necessary dosage is much smaller.

Duration:
DMT: peak 3-6 mins, residual effects up to 20-30 mins.
5-Me-O DMT similar, if not a little faster. Effects begin within a
few seconds of smoking, and increase in intensity very rapidly.
The experience of the onset could be compared with diving into
cold water.
DET: up to 2 hours.

Oral activity: none at reasonable doses. Oral activity is occasionally
claimed for DET in large quantities, although the literature is in
conflict over this, so I don't know.

Effect:
DMT is impossible to describe properly. The effects are quite unlike 
LSD, for example. Every time it is smoked, the perceived effects may
be quite different. It is exceedingly visual, and it is possible
by smoking enough to experience total visual hallucination. 
The visual distortions are often highly geometric in nature. The
impact on the auditory sense is less marked. Tactile hallucinations
are common. Often the brain remains conscious and clear thinking
for the duration, but perceives an entirely different universe.
The effect is definitely not subtle, and not always enjoyable,
but often profound. There is usually some respiratory distress,
and despite the highly stimulating nature of the experience,
DMT users often prefer to lie or sit for the duration.
DET is reported to be smoother, more euphoric, longer acting, 
more gentle and less "mind-blowing".
5-Me-O DMT is reported to be similar in physical and psychological
effect to DMT, but less visually oriented, and less profound.
Some users report visual distortions or hallucinations from
5-Me-O DMT, while others do not.


> 
> Which brings me one more question about DET. I've read a few files on DET
> and it sounds somewhat interesting. How could a FOAF obtain DET? Is it
> easily synthesizable (scoff), available in some legal form? Never noticed
> much of a black market for it.
> 

Synthesis:

DMT and DET are equally easy (or difficult) to synthesise from
indole or more easily from tryptophan. A person attempting such
an operation, quite apart from the legal problems, would want
to not only be trained in organic chemistry but also have good
equipment and a reasonable lab set up. On the scale of things, 
such a synthesis is probably more difficult than e.g. MDMA from 
sassafras, but easier than LSD from lysergic acid.
Producing 5-Me-O DMT from tryptophan or indole is a little more
difficult. If the 5-Me-O precursor were available, the process
would be equivalent.

DMT and 5-Me-O DMT occur in a range of plants, and 5-Me-O DMT
in Bufo alvarius. DET is entirely synthetic.

I suspect that there is little of a black market for these 
substances for several reasons: because the effects are so unusual, 
because the method of delivery is not aesthetically pleasing, 
because they are short acting, because persons engaging in 
illegal synthesis often prefer to concentrate on compounds 
of lower doseage, and because they are not well known.

The most interesting and promising tryptamines might well be
the methyl-isopropyl tryptamines. MIPT can be easily synthesised
from N-methyl tryptamine which is present in several plants.
4-OH-MIPT is reported to be a big cousin of psilocin
(see Shulgin, J.Med.Chem, 1985,28,892-896). These are active
at 30 and 10 mg resp, and last 3 and 6 hours resp.

Jeremy
jeremy@rsc3.anu.edu.au