From: stevet@ora.com (Steve Talbott)
Subject: GENE LEVEL DIAGNOSTICS handbook
Organization: O'Reilly & Associates, Inc.
Date: Tue, 8 Sep 1992 18:12:32 GMT

Title:    CRC Handbook of GENE LEVEL DIAGNOSTICS in CLINICAL PRACTICE
Author:   Victor Bernstam, M.D., Ph.D., BioSol, Ltd., Ann Arbor MI
Length:   695 pages (7" x 10" format)

[Availability information at end of this posting.]

(Note:  I am not associated with CRC Press.  I am posting this "review"
because of my interest in the work of the author.)

What follows is:
   1) a brief overview of the Handbook (about 1 page)
   2) a high-level outline of the book's contents
   3) a lower-level outline of one chapter

OVERVIEW
--------
The molecular anatomy of inherited and acquired conditions made possible
significant advances in many areas of medical practice.  A whole generation
of diagnostic tools probing diseases at the genome level have appeared in
recent years.

This Handbook offers a highly detailed overview drawn from thousands of
the latest reports in the world medical and basic science literature on
important diagnostic methods in internal medicine, pediatrics,
endocrinology, neurology, infectious diseases, oncology, gynecology, human
genetics, pathology, and forensic science.

Highlighted concepts include aging, repair, drug resistance,
metastasis, repetitive DNA, mitochondrial DNA, and the importance of
developments in the Human Genome Project to medical practice.

The Handbook provides extensive coverage of newer molecular biological
techniques available for diagnostic laboratories.  This Handbook explains
state-of-the-art developments in the science and practice of molecular
diagnostics indispensable to modern-day physicians and laboratorians.

In summary:  This Handbook will prove valuable to those primary care
physicians of all disciplines who are interested in gene level diagnosis
and monitoring of their patients.  It compares the potential of various
diagnostic modalities, including molecular probes.

(A briefer presentation of the material contained in the Handbook will be
available in quick-reference format in the forthcoming Pocket Guide to
Gene Level Diagnostics in Clinical Practice.)

OUTLINE
-------
Since space prevents anything but a very high-level outline of the
extensive contents of this book, I offer a more detailed outline of one
chapter at the end of this overall outline:

Part 1:  GENERAL ASPECTS OF GENE LEVEL EVALUATION:  SURVEY OF TECHNIQUES
         AND APPLICATIONS

Chapter 1.1. Introduction
Chapter 1.2  A Survey of Newer Gene Probing Techniques
Chapter 1.3  Prenatal Diagnosis
Chapter 1.4  Aging
Chapter 1.5  DNA Repair
Chapter 1.6  Drug Resistance
Chapter 1.7  Metastasis

Part 2:  GENE LEVEL EVALUATION OF SELECTED DISORDERS OF THE HEART, LUNG,
         GASTROINTESTINAL TRACT, AND TUMORS OF THE HEAD AND NECK

Chapter 2.1  Atherosclerosis and Coronary Heart Disease
Chapter 2.2  Gastrointestinal Diseases
Chapter 2.3  Hepatocellular Carcinoma
Chapter 2.4  Pancreas
Chapter 2.5  Cystic Fibrosis
Chapter 2.6  Lung
Chapter 2.7  Tumors of the Head and Neck

Part 3:  GENE LEVEL EVALUATION OF SELECTED BREAST, GYNECOLOGIC, AND
         UROLOGIC TUMORS

Chapter 3.1  Breast
Chapter 3.2  Tumors of the Uterine Cervix and Endometrium
Chapter 3.3  Ovarian Neoplasms
Chapter 3.4  Prostate Neoplasms
Chapter 3.5  Kidney and Urinary Bladder
Chapter 3.6  Wilms' Tumor

Part 4:  GENE LEVEL EVALUATION OF SELECTED ENDOCRINE DISORDERS

Chapter 4.1  Diabetes Mellitus
Chapter 4.2  Thyroid and Parathyroid Disorders
Chapter 4.3  Adrenal Gland and Multiple Endocrine Neoplasia 1 and 2

Part 5:  GENE LEVEL EVALUATION OF SELECTED NEUROLOGIC AND CONNECTIVE
         TISSUE DISORDERS

Chapter 5.1  Muscle, Bone, and Skin Disorders
Chapter 5.2  Neurologic and Mental Disorders

Part 6:  GENE LEVEL EVALUATION OF SELECTED INFECTIOUS DISEASES

Chapter 6.1  Molecular Biological Tools for Analysis of Infections
Chapter 6.2  Enteric Pathogens
Chapter 6.3  Respiratory Pathogens
Chapter 6.4  Sexually Transmitted Diseases
Chapter 6.5  Pathogens Causing Multisystem Infections
Chapter 6.6  Pathogens Transmitted by Arthropods
Chapter 6.7  Parasites

Part 7:  SELECTED ASPECTS OF GENE LEVEL EVALUATION IN HEMATOLOGY

Chapter 7.1  Hemoglobinopathies
Chapter 7.2  Coagulopathies
Chapter 7.3  Lymphoid and Myeloid Malignancies


MORE DETAILED OUTLINE OF ONE CHAPTER:
-------------------------------------
Chapter 2.1  Atherosclerosis and Coronary Heart Disease
   2.1.1  Introduction
   2.1.2  Synopsis of Molecular Biology of Dyslipoproteinemias
   2.1.3  Genetic Defects in Exogenous Lipid Transport
      2.1.3.1  Apolipoprotein E
      2.1.3.2  Apolipoprotein E Polymorphism:  Population studies
      2.1.3.3  apo E Gene Expression, Atherosclerosis and CHD
      2.1.3.4  apo E Genotyping Methods
         2.1.3.4.1  Polymerase Chain Reaction in apo E Assays
   2.1.4  Genetic Defects in Endogenous Lipid Transport
      2.1.4.1  Structure, Function and Mutations of Apolipoprotein B
      2.1.4.2  Heterozygous Hypobetalipoproteinemia and Abetalipoproteinemia
      2.1.4.3  Familial Defective Apolipoprotein B-100
      2.1.4.4  Polymerase Chain Reaction in the Analysis of apo B DNA
               Polymorphism
      2.1.4.5  Familial Hypercholesterolemia
      2.1.4.6  Lp(a)
         2.1.4.6.1  Lp(a) and Plasminogen
      2.1.4.7  Lp(a) in Coronary Heart Disease
   2.1.5  Genetic Defects in Reverse Cholesterol Transport
   2.1.6  Options in Predictive Molecular Genetic Testing for Coronary
          Heart Disease

AVAILABILITY
------------
CRC Press, Inc., 2000 Corporate Blvd, N.W., Boca Raton,
Florida 33431.
               
Tel: 1-800-272-7737 (continental US)
     407-994-0555 (elsewhere)

Price:  $99.50 (USA); $120.00 (elsewhere)
        30-day examination allowed
	
Steve Talbott
stevet@ora.com
Newsgroups: sci.med,sci.chem,sci.bio,sci.biotechnology
Subject: GENE LEVEL DIAGNOSTICS handbook

Title:    CRC Handbook of GENE LEVEL DIAGNOSTICS in CLINICAL PRACTICE
Author:   Victor Bernstam, M.D., Ph.D., BioSol, Ltd., Ann Arbor MI
Length:   695 pages (7" x 10" format)

[Availability information at end of this posting.]

(Note:  I am not associated with CRC Press.  I am posting this "review"
because of my interest in the work of the author.)

What follows is:
   1) a brief overview of the Handbook (about 1 page)
   2) a high-level outline of the book's contents
   3) a lower-level outline of one chapter

OVERVIEW
--------
The molecular anatomy of inherited and acquired conditions made possible
significant advances in many areas of medical practice.  A whole generation
of diagnostic tools probing diseases at the genome level have appeared in
recent years.

This Handbook offers a highly detailed overview drawn from thousands of
the latest reports in the world medical and basic science literature on
important diagnostic methods in internal medicine, pediatrics,
endocrinology, neurology, infectious diseases, oncology, gynecology, human
genetics, pathology, and forensic science.

Highlighted concepts include aging, repair, drug resistance,
metastasis, repetitive DNA, mitochondrial DNA, and the importance of
developments in the Human Genome Project to medical practice.

The Handbook provides extensive coverage of newer molecular biological
techniques available for diagnostic laboratories.  This Handbook explains
state-of-the-art developments in the science and practice of molecular
diagnostics indispensable to modern-day physicians and laboratorians.

In summary:  This Handbook will prove valuable to those primary care
physicians of all disciplines who are interested in gene level diagnosis
and monitoring of their patients.  It compares the potential of various
diagnostic modalities, including molecular probes.

(A briefer presentation of the material contained in the Handbook will be
available in quick-reference format in the forthcoming Pocket Guide to
Gene Level Diagnostics in Clinical Practice.)

OUTLINE
-------
Since space prevents anything but a very high-level outline of the
extensive contents of this book, I offer a more detailed outline of one
chapter at the end of this overall outline:

Part 1:  GENERAL ASPECTS OF GENE LEVEL EVALUATION:  SURVEY OF TECHNIQUES
         AND APPLICATIONS

Chapter 1.1. Introduction
Chapter 1.2  A Survey of Newer Gene Probing Techniques
Chapter 1.3  Prenatal Diagnosis
Chapter 1.4  Aging
Chapter 1.5  DNA Repair
Chapter 1.6  Drug Resistance
Chapter 1.7  Metastasis

Part 2:  GENE LEVEL EVALUATION OF SELECTED DISORDERS OF THE HEART, LUNG,
         GASTROINTESTINAL TRACT, AND TUMORS OF THE HEAD AND NECK

Chapter 2.1  Atherosclerosis and Coronary Heart Disease
Chapter 2.2  Gastrointestinal Diseases
Chapter 2.3  Hepatocellular Carcinoma
Chapter 2.4  Pancreas
Chapter 2.5  Cystic Fibrosis
Chapter 2.6  Lung
Chapter 2.7  Tumors of the Head and Neck

Part 3:  GENE LEVEL EVALUATION OF SELECTED BREAST, GYNECOLOGIC, AND
         UROLOGIC TUMORS

Chapter 3.1  Breast
Chapter 3.2  Tumors of the Uterine Cervix and Endometrium
Chapter 3.3  Ovarian Neoplasms
Chapter 3.4  Prostate Neoplasms
Chapter 3.5  Kidney and Urinary Bladder
Chapter 3.6  Wilms' Tumor

Part 4:  GENE LEVEL EVALUATION OF SELECTED ENDOCRINE DISORDERS

Chapter 4.1  Diabetes Mellitus
Chapter 4.2  Thyroid and Parathyroid Disorders
Chapter 4.3  Adrenal Gland and Multiple Endocrine Neoplasia 1 and 2

Part 5:  GENE LEVEL EVALUATION OF SELECTED NEUROLOGIC AND CONNECTIVE
         TISSUE DISORDERS

Chapter 5.1  Muscle, Bone, and Skin Disorders
Chapter 5.2  Neurologic and Mental Disorders

Part 6:  GENE LEVEL EVALUATION OF SELECTED INFECTIOUS DISEASES

Chapter 6.1  Molecular Biological Tools for Analysis of Infections
Chapter 6.2  Enteric Pathogens
Chapter 6.3  Respiratory Pathogens
Chapter 6.4  Sexually Transmitted Diseases
Chapter 6.5  Pathogens Causing Multisystem Infections
Chapter 6.6  Pathogens Transmitted by Arthropods
Chapter 6.7  Parasites

Part 7:  SELECTED ASPECTS OF GENE LEVEL EVALUATION IN HEMATOLOGY

Chapter 7.1  Hemoglobinopathies
Chapter 7.2  Coagulopathies
Chapter 7.3  Lymphoid and Myeloid Malignancies


MORE DETAILED OUTLINE OF ONE CHAPTER:
-------------------------------------
Chapter 2.1  Atherosclerosis and Coronary Heart Disease
   2.1.1  Introduction
   2.1.2  Synopsis of Molecular Biology of Dyslipoproteinemias
   2.1.3  Genetic Defects in Exogenous Lipid Transport
      2.1.3.1  Apolipoprotein E
      2.1.3.2  Apolipoprotein E Polymorphism:  Population studies
      2.1.3.3  apo E Gene Expression, Atherosclerosis and CHD
      2.1.3.4  apo E Genotyping Methods
         2.1.3.4.1  Polymerase Chain Reaction in apo E Assays
   2.1.4  Genetic Defects in Endogenous Lipid Transport
      2.1.4.1  Structure, Function and Mutations of Apolipoprotein B
      2.1.4.2  Heterozygous Hypobetalipoproteinemia and Abetalipoproteinemia
      2.1.4.3  Familial Defective Apolipoprotein B-100
      2.1.4.4  Polymerase Chain Reaction in the Analysis of apo B DNA
               Polymorphism
      2.1.4.5  Familial Hypercholesterolemia
      2.1.4.6  Lp(a)
         2.1.4.6.1  Lp(a) and Plasminogen
      2.1.4.7  Lp(a) in Coronary Heart Disease
   2.1.5  Genetic Defects in Reverse Cholesterol Transport
   2.1.6  Options in Predictive Molecular Genetic Testing for Coronary
          Heart Disease

AVAILABILITY
------------
CRC Press, Inc., 2000 Corporate Blvd, N.W., Boca Raton,
Florida 33431.
               
Tel: 1-800-272-7737 (continental US)
     407-994-0555 (elsewhere)

Price:  $99.50 (USA); $120.00 (elsewhere)
        30-day examination allowed
	
Steve Talbott
stevet@ora.com
Newsgroups: sci.med