From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: properdin [human, GM1416B cell line, Genomic, 8222 nt]
Date: 27 Jan 93 05:52:08 GMT
Distribution: bionet
Checksum: 05373 13

LOCUS       S115440      8222 bp    DNA             PRI       12-JAN-1993
DEFINITION  properdin [human, GM1416B cell line, Genomic, 8222 nt]
ACCESSION   S46256
KEYWORDS    .
SOURCE      human GM1416B cell line
  ORGANISM  Unclassified.
            Unclassified.
REFERENCE   1  (bases 1 to 8222)
  AUTHORS   Nolan,K.F., Kaluz,S., Higgins,J.M., Goundis,D. and Reid,K.B.
  TITLE     Characterization of the human properdin gene.
  JOURNAL   Biochem. J. 287 ( Pt 1), 291-297 (1992)
  STANDARD  full automatic
COMMENT     This entry [NCBI gibbsq 115440] was created by the journal scanning
            component of NCBI/GenBank at the National Library of Medicine.
            This sequence comes from Fig. 2.  Map location: X.
FEATURES             Location/Qualifiers
     mRNA            join(1745..1921,2141..2281,2376..2526,3774..3949,
                     4410..4580,4719..4910,5105..5278,5532..5723,5882..5993,
                     7610..7824)
     CDS             join(2206..2281,2376..2526,3774..3949,4410..4580,
                     4719..4910,5105..5278,5532..5723,5882..5993,7610..7775)
                     /note="For the protein sequence (NCBI gibbsq 115441):
                     Method: conceptual translation supplied by author.  This
                     sequence comes from Fig. 2.  Map location: X.  The authors
                     begin their numbering at -27.  Zero is not present in the
                     numbering."
                     /product="properdin"
                     /codon_start=1
                     /translation="MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCK
                     GLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYR
                     RCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRR
                     RACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKE
                     TRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLG
                     QTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKS
                     ISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCM
                     PPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVE
                     EKRPCLHVPACKDPEEEEL"
BASE COUNT     1920 a   2185 c   2245 g   1872 t
ORIGIN      
        1 gtcgacaagc ttatcgatac agctggatcc acctgcctca atctcccaaa gtgttgggat
       61 tacaggcgtg agcaccatgc ctggccagtt tcaggtctct tggagagtgt tttcacagga
      121 taacacagca atgattgtct tgaagtcgta gaatcttaat aagactcctt tgttcaaagc
      181 acattttcaa ggatagcctt atgttatcag agaacagagt atgtctgtaa tggatacaga
      241 tattaacaca tactttactg cccataaaac aagtgttcct gaagaacttc tgttttaaca
      301 gctgaccaaa ttattacatt tgaatttgca gaattcctct gcctccctga gagcagagga
      361 aattaggcat tgccttccta tctttcttgt gcttcttttt gttattaaaa gcaaaataaa
      421 aattttaaag tgggccctgg agtttcatta gggtttataa aaaaaaaata aaaaaataaa
      481 aaaaaaagaa gggctggtgt gatggctcat gcctgtaatc ccagcacttt gggaggctga
      541 ggttgggaga aaatattgaa gccaggagtt tgagaccagc ctgggcaaca caacgagacc
      601 ccatctatac agaaaataaa aacattagtt gtgtggtggt gtgtgcctgt agtcccagct
      661 acttggggac gctaaggtgg gaaaatcact tgagcccagg agtttgaggc tgcaatgacc
      721 tatgatcaga ccactgcact ccagcccagg tgacagcaag actctgtctc tttaaaacaa
      781 aacaaacaaa aaaacaggtt tggaagctac tgggctagag agtgacaggg atgccagaca
      841 agggtatggg gaaggcctct gtgaggaggg gcaacatttg ttatccatct tctcgagggc
      901 caggattttt gtctgtccta ttctctgctc taatgctaag aaccgcatct ggcatccagt
      961 aggtgctcaa taaatgttga ataaatttat caaacacaga gcacctacta tatgccaggc
     1021 actgttctaa agactttcca aaagcttaac tcctggccgg gcacggtgac tcacgcctgt
     1081 aatcctagca ctttgggagg ccaaggcagg tggataacct gaggtcagga gttcgagacc
     1141 agcctgccca acatggtgaa accctgtctc cactaaaaat acaaaaatta gctggacatg
     1201 gtggtacacg gctgtaatcc cagctactca ggaggctgag gcaggagaat tggttgaaat
     1261 cgggaggcag aggttgcagt gagccgagat cgtgacactg cacgccagcc tgggcgacgg
     1321 agtgagactc catctcgaca aaacaaacaa aagcttaact cgcaatcttt gcaacacacc
     1381 ctacctatgt tgtaggtgct gtctgtgagc acattttaca gaggggaaac aggctccaga
     1441 aggggggtgt tatctgcctg agggttctct gatggaatat ggcccagctt attccctcct
     1501 aatcacccca gaccctggtg ttgtccccag ctgggcccat ggaacaatgg atagacccca
     1561 ttcccctcct gaatccctcc ccaggctcct gccacttccc tttctcactt cccttgtgct
     1621 gacctccccg accacaagct gaccacaggg aacctctcag gaaaggaggg ccgaggttaa
     1681 gggagggtgg aaggtggagc aactgactcg atgctccctc cacccccacg agcaggaaca
     1741 tactgagcac cgcacactca cttcaccctg gttcaacacc cccacgaggt tgaccccgtc
     1801 attatgttag agattatgca ttttccacat agggaaactg aggctcaggg gtgttaagtg
     1861 actcacccaa ggtcacacgg ctaggaagtt gctgcacgct cctatgctcc atttcctctg
     1921 ggtgagaatt tgtcctagga gcttctattg aacactgtga ggttgctggg aggagcgcga
     1981 ggtgctgggg atatagtaac aaacagaaca agaccaagag taagacagga aatggggagg
     2041 ggagagtaga gaaggaggca gaggggacag ggtggggtca aagcaggatg ccctcccagt
     2101 tcctcctgcc tctaggttcc tctttccctg ctgattccag gagcctatca acccagataa
     2161 agcgggacct cctctctggt agaggtgcag ggggcagtac tcaacatgat cacagaggga
     2221 gcgcaggccc ctcgattgtt gctgccgccg ctgctcctgc tgctcaccct gccagccaca
     2281 ggtgaggggg tgagggccca gctggcccca ggggtgtcca ggcccaccac atccctgacc
     2341 gagccccacc cacccatccc ctggccctgt tacaggctca gaccccgtgc tctgcttcac
     2401 ccagtatgaa gaatcctccg gcaagtgcaa gggcctcctg gggggtggtg tcagcgtgga
     2461 agactgctgt ctcaacactg cctttgccta ccagaaacgt agtggtgggc tctgtcagcc
     2521 ttgcaggtta gggggagcct ggggtggggg atggggggga gggaaggact gtctgtgggg
     2581 gtcacccaaa actgggcact ttctttctct gggacttcca agggtggccc tgaggccctg
     2641 atcgtgacca tacctcaggg tttctcaacc ttgttactat tgacatttgg ggctggaaat
     2701 tcttggctgg gggaggggat tgcttacctg tgtattgtgg gatgttttgt aacaccccta
     2761 gccttccact agatgccagt agcaattctc cccaccagct gtgacaacca aacatgtcag
     2821 cagacattgc caaatgtccc ctgggggtca aaatcacccc tgattgagaa ccactgacat
     2881 agctcacaca tattgagcac ctcctgcaca ctggaagcat tgcaggtggg gtgcagcttg
     2941 gtatttccct aattttgatg acagctcatg tttattgagt gcttactgta tatggacaca
     3001 ctgtgggggc gggaaagttt ggggaattca aagggcagct ctaggcccct aattatgatg
     3061 acacttcaca ttcattgagc actccctgta taccagctgc atggcagggt tgggagatga
     3121 gcttgaggat ttctgagggt agctctagtc tcctgatcat gatttccagc ttgcatggat
     3181 tgagccctta ccgtatgcca gacctgtttt ctacttgttt actatatatc ccagatacac
     3241 cgtgggcatg gggagcttgg ggatttttga gggcagctct gggccccaag tcatgtcaac
     3301 agttcatcac atctatttgg catgaacagc atacctaggg ctatgcagtg ggttggggat
     3361 agatctgggg ttatttctga ggaggcctct gaggtcatag ggatgatggc tcaggtttat
     3421 taagcacttt ctatttacct actaccgtgt agtgtggtga tctggtgggt ttctgacagc
     3481 agcccttggt ttctagtcct tacctttgct tactgcggac ctggtgttgg ccatgccagc
     3541 cttccaatgg taactccaga tgcctgattg tgaaggtaaa tgacattatc aagcacttat
     3601 tgtatatcca ctgcttccca tcagtatccc aatatcccta aaaggtaagg acttatcaat
     3661 ccatcgcaca cgcacttgcc tagcaaccct tcgtgtctgc ccacactctg gagtcccaca
     3721 tgccattctt gttagctcat gccaggatgg gatgtgtgtg ctcttctcca caggtcccca
     3781 cgatggtccc tgtggtccac atgggccccc tgttcggtga cgtgctctga gggctcccag
     3841 ctgcggtacc ggcgctgtgt gggctggaat gggcagtgct ctggaaaggt ggcacctggg
     3901 accctggagt ggcagctcca ggcctgtgag gaccagcagt gctgtcctgg tgaggaggat
     3961 gagcaaggcg ggcaagcact ccctgtcacc cagcactggt gggaacgatc ggtacagagg
     4021 tcctcagagt gggcccgtcc ccagtgtttg taaggaccta aggaggagag tggtgggagg
     4081 tgaggtcaga gaggtgagga gggtccattg cctgggggcc acagagagga cgttggcttt
     4141 tcatctgagt aatttggact gtgggcagag gaggaacgtg atctgactgg ggttgggagg
     4201 agaacagact gtgcacggtg agggtgagag gggaagcgga ggcacccatg tgaaggttgc
     4261 tgcggcaggc ccggtgagcg gggatggtgg gcccagaatg gtggcagagg atataaggac
     4321 aggattagct catgtggggc actcaaggaa gcaaagagcc ctgaatgaca ccccacctcc
     4381 atcccattac cctctcttct ctcccacaga gatgggcggc tggtctggct gggggccctg
     4441 ggagccttgc tctgtcacct gctccaaagg gacccggacc cgcaggcgag cctgtaatca
     4501 ccctgctccc aagtgtgggg gccactgccc aggacaggca caggaatcag aggcctgtga
     4561 cacccagcag gtctgcccca gtgagtgagg gaagccacag gatgctgatg ggtgcaccca
     4621 gcgtgggtct gcggggttac agcagggaac tgccaggctg agaggacttt agcatgcatg
     4681 accacacctg catccctcca cctcccaccc caccacagca cacggggcct gggccacctg
     4741 gggcccctgg accccctgct cagcctcctg ccacggtgga ccccacgaac ctaaggagac
     4801 acgaagccgc aagtgttctg cacctgagcc ctcccagaaa cctcctggga agccctgccc
     4861 ggggctagcc tacgagcagc ggaggtgcac cggcctgcca ccctgcccag gtacaccagg
     4921 atgaggctgc tgatgttgct ggtggggctc ttgattgagg gcagagatgc tctgccattt
     4981 ctagagttcc taggccatgt gaccatgcag cccttcattt ggggacagtc tgcttcaagg
     5041 gtctaggggc tgagaggaag gattgaggag gcctttctcc tcactccctt tcctcctcca
     5101 acagtggctg ggggctgggg gccttggggc cctgtgagcc cctgccctgt gacctgtggc
     5161 ctgggccaga ccatggaaca acggacgtgc aatcaccctg tgccccagca tgggggcccc
     5221 ttctgtgctg gcgatgccac ccggacccac atctgcaaca cagctgtgcc ctgccctggt
     5281 cagcatctca gggttcacga tttgcatgcc taagtccccc ttgcccttct ctgctgccca
     5341 gctcctgctg ctgaggcctt gttcctgtct ctgattcctc ctttcctggc cctgatacct
     5401 tgtttccacc cctggtcccc cattcacaca tctgatcacc tctactccct cctaccgccc
     5461 tcattccttc ctctgaaccc ccttgctgat tccctgcttt ggtccaatcc cctgttgccc
     5521 tgtctctgca gtggatgggg agtgggactc gtggggggag tggagcccct gtatccgacg
     5581 gaacatgaag tccatcagct gtcaagaaat cccgggccag cagtcacgcg ggaggacctg
     5641 caggggccgc aagtttgacg gacatcgatg tgccgggcaa cagcaggata tccggcactg
     5701 ctacagcatc cagcactgcc cctgtgagtg tcccacagac tgtgctctga gggtggggtg
     5761 gcccatgcag gataaggggt ttccaactct ctgctgtgga cctcacgtct ctgcagcctc
     5821 cctctcactt tcccaccaag acctccagtt ctgactctgt gacccctacc cctcattgca
     5881 gtgaaaggat catggtcaga gtggagtacc tgggggctgt gcatgccccc ctgtggacct
     5941 aatcctaccc gtgcccgcca gcgcctctgc acacccttgc tccccaagta cccgtgagtg
     6001 agagggcaaa gtatgcctgg gagggggtca ttatattaca ggcgggagag tcggctaccc
     6061 caggaaacca gggtttccac tgctgaatct aaggtatctg ccttgccgag tgccacctcc
     6121 cagctgcagg aagtggggag aaactaagaa gatgagaaag aagttcttgg aggataattc
     6181 gtagcctctg tgcccctcag tcacttgttc agtcactcat ccacttagtc cttcatgtgt
     6241 cattgactcc gaccttcagt tacccatgct tttagctgcc atcactcagg cctccattca
     6301 ctgcctgcct cccacagtca ctcatgcctc catccacttt ctcagcatct cactgagcca
     6361 aggcactcca aggctttttc agcaacagtt gcagatacac acagcccaga tcctgtggat
     6421 cctccaaggg acccagctga gcaagccctg acaggaggca tatgaggaac agctggtgca
     6481 tgcaacaggt gctgccacct caacctaggt ccaggaagct gactgggcct cccagggcag
     6541 gtaggggttg ggaaaggcat tcctggcatc aagactgtga acggagcctt ggagctaggt
     6601 gattagccgc tataagtgtt tccaggtgcc agaggggccc aggtgttaga gagggttaaa
     6661 atgttcatcc cttttcttcc ttccacatac atcaagctac tagattaagt gaactattcc
     6721 cagctcgtgg aagggctgcc atctgggaag ggatctcccg gctgaggggg ttagagtggg
     6781 gcctgaagat tagaggtctt gaatggaggc acaaaggact tgagtgagcg agagactgag
     6841 tggaggaaga agcaattgag agaactggga tgggagtgaa tggagggctt tcctagtggg
     6901 acaaataacc caggtaaaga cctttctgga cagggactga gcttgaataa agtggaggag
     6961 acagagagag agattggctt ggggcaggga tttgggccca acaataaggc cttgaatgtc
     7021 aggacaaggc attgggtttt ttcctggagg cagtggaaag agatataaag ggtatatatt
     7081 tcggaggtaa aagaaagtag ctcatgccaa caagtaacat tcaccagcat ttattgagca
     7141 cttgctgtgt gccaggcact gctctgagca ctttacctga attaactcat ttatcctcat
     7201 tcaaccccgt gaggtgagta ttaatattac tattcctacc attctcattt tgcagatgag
     7261 ggaaaccgag gcacagagaa gctaaagaaa ttgcccaata tcctatagct aaaaagtagt
     7321 gttgggaggc caggcacagt ggctcacgcc tgtaatccca gcaacacttt gggaggctga
     7381 ggcaggagca tcacttgagc ccaggagatt gaggctgcag tgagctatga ttgagccact
     7441 gcactgcagc ctgggcaaca gagtgagacc ctgcctcaaa aaaaaaaaag gaaaaaaaaa
     7501 aaaaaaaaaa gtagccctcg gcatatagca ggcactcaat aagaattgaa tgcattcttg
     7561 ccttccctga gattctccct tccgttcctc cccaccccta atgcctcagg cccaccgttt
     7621 ccatggtcga aggtcagggc gagaagaacg tgaccttctg ggggagaccg ctgccacggt
     7681 gtgaggagct acaagggcag aagctggtgg tggaggagaa acgaccatgt ctacacgtgc
     7741 ctgcttgcaa agaccctgag gaagaggaac tctaacactt ctctcctcca ctctgagccc
     7801 cctgaccttc caaacctcaa taaactagcc tcttcgagtt cgtctacgat tccttaaagg
     7861 aggaaaaaca acctatcccc ttccccaaaa gtagggtgat agcatctcat agggcaaaca
     7921 gcacagcacg ggccaagaca cagcagcctg ttgcggaaaa cagtattttc cactgtggtc
     7981 gcaggttggc aggagtgaaa gcgagtgtgc agtcccagcc tctccccgcc gctgccataa
     8041 cccaatgtct gggccctgcg cagccccctt agagcctcag ggccgcccgg cacgttcctc
     8101 tgcagagctc cgcgttacgg gtttcctgat tggctacttg tcctggcagg cacttcttga
     8161 ttggccggcg tgcttgttcg ttgtctcccc gtctcctgga cctccctaga ttcccaccag
     8221 cg
//