HDTenEightyP/NetNews huggingface dataset:
From: rsorense@CC.GETTYSBURG.EDU (Ralph A. Sorensen)
Newsgroups: bionet.immunology
Subject: ABO
Date: 5 Jan 93 13:45:15 GMT
Distribution: bionet

In the case of blood transfusion reactions to A and B carbohydrates, 
antibodies are present in the recipient before exposure to these 
foreign cells. Why? What causes the raising of these antibodies prior 
to transfusion? Reference?

                              Ralph A. Sorensen                                
                              Biology Department, Gettysburg College             
                              (717) 337-6168
                              rsorense@cc.gettysburg.edu
From: GWU5042@gwuvm.gwu.edu (Dr. V. Hu)
Newsgroups: bionet.announce
Subject: CELL CYCLE MEETING
Date: 8 Jan 93 15:16:54 GMT


        XIIIth Washington International Spring Symposium
                     May 10-14, 1993
              The George Washington University
                      Washington, D.C.

Topic:  THE CELL CYCLE:  REGULATORS, TARGETS AND CLINICAL APPLICATIONS

     The symposium will include talks by invited speakers as well as
contributed oral and poster presentations in following major areas of
research:

1.  G0/G1 transition
2.  G1/S transition (control of DNA replication, etc.)
3.  mitosis: induction and mechanics  (regulation of mitosis and changes
         in cell architecture)
4.  cell cycle-dependent transcription/ post-transcriptional regulation
5.  cell cycle regulaton in development (embryogenesis, differentiation,
          senescence, apoptosis)
6.  cell cycle regulation in carcinogenesis and other diseases
7.  clinical applications of cell cycle analysis and intervention


      Plenary speakers are J. C. Barrett, David Beach, David Brautigan, Melanie
Cobb, Michael Czech, Guilio Draetta, Alan Eastman, Lazaro Gershenson,
Nathaniel Heintz, Lee Johnson, Kurt Kohn, Amy Lee, Arnold Levine, Werner
Loewenstein, Robert Margolis, W. Gillies Mckenna, Joseph Nevins, Patrick
O'Farrell, Arthur Pardee, Steven Patierno, Jonathan Pines, Helen Piwnica-Worms,
Ruth Sager, Robert Schlegel, Charles Sherr, Gretchen Stein, George Vande Woude,
Eugenia Wang, Ted Weinert, Katherine Wilson.

      The keynote addresses are Dr. Tim Hunt and Dr. James Maller.

      For information and abstract materials, contact Dr. Valerie Hu, Dept. of
Biochemistry and Molecular Biology, The George Washington Univ. Medical Center,
2300 Eye street, NW, Washington, D.C., 20037, USA.  Phone: (202) 994-3709 or
internet: gwu5042@gwuvm.gwu.edu, bitnet: gwu5042@gwuvm.bitnet
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: Babak Sehari postings
Date: 5 Jan 93 20:08:18 GMT
Organization: BIOSCI International Newsgroups for Biology

FYI.  Our apologies to those who may have received up to 30 copies
from this person in their mail files.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net


----------------------------------------------------------------------
From news.admin.policy Tue Jan  5 12:05:50 1993
From: jik@athena.mit.edu (Jonathan I. Kamens)
Newsgroups: news.admin.policy
Subject: Babak Sehari postings -- iastate.edu is dealing
Date: 5 Jan 93 17:06:30 GMT
Organization: Massachusetts Institute of Technology
NNTP-Posting-Host: pit-manager.mit.edu

The poster flooding the net with copies of the same message in every newsgroup
is being dealt with.  When I started seeing the messages, I sent mail to the
News administrator at his site asking for something to be done about it, and I
just got back this mail message (which I consider OK to post since it's a form
letter that was sent out to anyone who wrote to the news administrator of the
site about the problem):

-----

~Date: Tue, 5 Jan 93 10:33:06 -0600
~From: skunz@news.iastate.edu (Steven L. Kunz)
To: jik@pit-manager.mit.edu
~Subject: Babak Sehari postings

Network News User:

Regarding the "junk mail" type of postings that have originated from
news.iastate.edu from a user named "Babak Sehari" ...

Mr. Sehari has apparently automated his posting process and is posting his
article to a large selection of newsgroups (including ALL local and regional
ones) from a variety of systems on our campus.  This matter has been turned
over to the ISU Computation Center administrator in charge of handling
perceived abuse of computer or network facilities at Iowa State University.

Please forgive the "form letter" format of this reply.  I have received many
email complaints as Usenet News admin on this matter (as has our local
"postmaster" for this site).

---
Steven L. Kunz
Networked Applications | Usenet News Admin.
Iowa State University Computation Center, Iowa State University, Ames  IA
INET: skunz@iastate.edu     BITNET: gr.slk@isumvs.bitnet

-----

-- 
Jonathan Kamens                                         jik@MIT.Edu
Aktis, Inc.                                 Moderator, news.answers
From: POSTMASTER@NBRF.Georgetown.Edu
Newsgroups: bionet.announce
Subject: Announcement of PIR Service Interruption
Date: 4 Jan 93 19:32:43 GMT


            Announcement of Temporary Interruption of Access to
                   The Protein Identification Resource

The National Biomedical Research Foundation will (once again) be attempting
to repair a hardware problem on Tuesday 5 January.  From 12:00 EST Tuesday 5
January through about 17:00 EST Wednesday 6 January it will not be possible
for users to access the Protein Identification Resource Network Server.  The
On-line System is currently unavailable but should be back up when the system
is restored.

We regret any inconvenience this temporary loss of service will cause.
------------------------------------------------------------------------
                                 Dr. John S. Garavelli
                                 Database Coordinator
                                 Protein Information Resource
                                 National Biomedical Research Foundation
                                 Washington, DC  20007
                                 POSTMAST@GUNBRF.BITNET
                                 POSTMASTER@NBRF.GEORGETOWN.EDU
From: harper@finsun.csc.fi (Robert Harper)
Newsgroups: bionet.announce
Subject: Re: List of molecular biology email servers (Preliminary edition).
Date: 7 Jan 93 21:03:30 GMT
Organization: Centre for Scientific Computing, Finland (CSC)

I have gone through the list of E-mail servers provided by Amos
and collected all the help files. They are now available for
on-line reading in the FAQ files of the Finnish EMBnet gopher.

%%%%%%%%%%%%%%%%%%% CLIP from EMBnet Finnish BioBox %%%%%%%%%%%%%%%%%%%

             Collection of help files from E-mail servers.

      1.  GENE-ID EMAIL INFO.
      2.  RETRIEVE E-Mail Server Help Document.
      3.  Help from Mail-QUICKSEARCH service.
      4.  PYTHIA (Server for identification of human repetitive DNA).
      5.  Protein Prediction PHD.
      6.  NetGene splice site prediction.
      7.  GRAIL (Gene Recognition and Analysis Internet Link).
      8.  NETSERV general help.
      9.  DARWIN help.  .
      10. DAPMAIL help.
      11. BLAST E-Mail Server Help Document.
      12. PIR E-mail server.
      13. Japanese E-Mail network Server..
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

I will endevour to keep this file up to date... so if you hear of anyone
offering a E-mail service and it is not listed please let me know.

RGDS -=ROB=-



% Robert Harper                   %   HARPER@FINFUN   %   HARPER@CSC.FI   %
% Finnish State Computer Centre   %      Bitnet       %     Internet      %
% Tietotie 6, 02101 Espoo Finland % Tel 358 0 4572076 % Fax 358 0 4572302 %
From: Blitz@EMBL-Heidelberg.DE
Newsgroups: bionet.announce
Subject: MPsrch:  announcing a new service.
Date: 12 Jan 93 16:57:37 GMT
Organization: European Molecular Biology Laboratory, Heidelberg


                             MPsrch
                             ------

       (C) Biocomputing Research Unit, University of Edinburgh, 1992

     Smith and Waterman Protein Sequence Database searches on a MasPar  


  MPsrch (by Shane Sturrock and John Collins), the fastest implementation
  of the exhaustive Best Local Similarity algorithm for Sequence Database
  searching, is now available through BLITZ, a new e-mail service from the
  EMBL.  MPsrch runs on the 4096-processor MasPar MP-1 machine at the EMBL,
  using the Smith & Waterman algorithm, performing up to 140,000,000 cell
  updates per second.

    Typical search times on the MasPar against Swiss-Prot 23 are:

  5037 residues  RYNR_RABIT  340 seconds  (134,000,000 cell updates/second)
   377   "       ACTS_HUMAN   40 seconds  ( 85,000,000 cell updates/second)


  To get current help information, e-mail the word HELP in a mail message to
  the Internet address:

	Blitz@EMBL-Heidelberg.DE


  To run a search, using default weight matrix and INDEL cost settings, try
  sending an e-mail message with the word SEQ on the first line and the 
  sequence in free format on succeeding lines.   The end of the sequence is 
  determined either by the end of your mail message, if you do not use an 
  automatic mail signature, or by inserting a new line beginning with the 
  word END. 
  For example:

SEQ
	STKKKPLTQE QLEDARRLKA IYEKKKNELG LSQESVADKM GMGQSGVGAL
	FNGINALNAY NAALLAKILK VSVEEFSPSI AREIYEMYEA VSMQPSLRSE
	YEYPVFSHVQ AGMFSPELRT FTKGDAERWV STTKKASDSA FWLEVEGNSM
	TAPTGSKPSF PDGMLILVDP EQAVEPGDFC IARLGGDEFT FKKLIRDSGQ
	VFLQPLNPQY PMIPCNESCS VVGKVIASQW PEETFG
END


  The Help information explains how you can specify a PAM matrix between 1
  and 500 PAM's, an INDEL cost and the number of alignments to be returned
  in the output.

  The sensitivity of MPsrch depends on the choice of parameters, and
  searches with default parameter settings alone may not always find the
  most interesting results.  Even with the same query sequence, one set of
  parameters may find strong alignments best, while a different setting may
  show up weaker relationships better.  Because the search is so fast, we would
  encourage you to experiment with your own choice of parameter settings.

  In future developments, we hope to provide searches of other databases,
  including a nucleotide search facility.  


  John Collins & Shane Sturrock,                    Des Higgins (Data Library)
  Biocomputing Research Unit,                     & Roy Omond (Computer Group)
  University of Edinburgh,                            EMBL,
  Scotland,                                           Heidelberg,
  U.K.                                                Germany.
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: BIOSCI FAQs will be changed
Date: 13 Jan 93 01:45:12 GMT
Organization: BIOSCI International Newsgroups for Biology

BIOSCI/bionet will no longer be distributing the FAQ composed by Una
Smith at her request (BIOSCI FAQ I).  Una is free to distribute her
document as she sees fit, but it will be an individual effort and not
part of the official BIOSCI/bionet information distribution.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: kristoff@net.bio.net (Dave Kristofferson)
Newsgroups: bionet.announce
Subject: GREAT NEWS!!! COMMERCIAL JOB POSTING DILEMMA RESOLVED!!!
Date: 8 Jan 93 19:55:12 GMT


I am happy to announce a significant breakthrough!!!  Commercial job
postings have been approved on this newsgroup (EMPLOYMENT/bionet.jobs)
as long as they follow the guidelines listed below.  My thanks to
Henry Schaffer for formulating a compromise and to Steve Wolff at NSF
for approving it!  Excerpts from his response to my letter are
provided below.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net

                ---------------

To: Dave Kristofferson <kristoff>
Subject: Need to talk to Steve Wolff ASAP
Cc: gilbertd@silver.ucs.indiana.edu, ernest@lenti.med.umn.edu
Date: Fri, 08 Jan 93 12:31:10 EST
From: Stephen Wolff <steve@cise.cise.nsf.gov>

Dave - It has indeed been an unconscionably long time, and I apologize.

->        I discussed this with Henry Schaffer, who I believe you know,
->at a recent meeting in DC and he suggested a possible compromise.  I
->would like to have permission to allow the posting of a job title and
->a one or two line description of the position plus a contact e-mail
->address.  This will keep the size of the commercial postings to a
->minimum.  Only postings for professionals in the area served by
->BIOSCI/bionet would be allowed.  I sincerely hope that you can give me
->the O.K. on this.  I think that U.S. science will be much better
->served if trained people can find jobs.  The network is one of the
->best ways to bring people and job opportunities together, and the old
->regulations are severely hampering this effort.

(...)

Henry was always a voice of reason.  His suggestion is just exactly
right and NSF is happy to authorize the use as described, providing in
addition that the postings be limited to discipline-specific lists
(e.g., bionet.jobs) on which subscribers may have a reasonable
expectation of receiving such postings.

The bases of this authorization are paragraphs (1), (3), (4), and (6) of the
THE NSFNET BACKBONE SERVICES ACCEPTABLE USE POLICY (June 1992).

-s
From: dab@ray.nlm.nih.gov (Dennis Benson)
Newsgroups: bionet.announce
Subject: Another FTP source for GenBank
Date: 8 Jan 93 17:51:35 GMT
Organization: National Library of Medicine


In addition to NCBI as a source of GenBank files, the folks at the
Pittsburgh Supercomputing Center (PSC) have kindly made the GenBank flat files
available through anonymous FTP.  Thanks to Hugh Nicholas and
Alex Ropelewski.

They provide everything in the NCBI 'ncbi-genbank' directory tree
including the full release and daily cumulative and non-cumulative updates.
Update files are copied over nightly from NCBI.

To access the files:

 SERVER:    ftp.psc.edu
 USER:      anonymous
 PASSWORD:  <Email-address> 
 DIRECTORY: biomed/genbank/annotated

If users are running the Andrew File System (AFS) and have the PSC cell 
(psc.edu) mounted, they should be able to copy the files from:

     /afs/psc.edu/usr/anonymous_ftp/biomed/genbank/annotated
  
If you have any questions contact Alex Ropelewski at PSC (ropelews@psc.edu).


Dennis Benson
NCBI
National Library of Medicine
benson@ncbi.nlm.nih.gov
From: jrawles@leland.Stanford.EDU (jody rawles)
Subject: Whatis Dupree's Syndrome ?
Organization: DSG, Stanford University, CA 94305, USA
Distribution: na
Date: Tue, 12 Jan 93 23:44:33 GMT

We have motor testing on a research subject who claimed
to have "Dupree's Syndrome" in his right hand.  Could
someone please tell me what this is.

Thanks,
-- 
Jody M. Rawles			email: jrawles@leland.stanford.edu
Stanford University 		voice: (415) 858-3914
Stanford, CA 94305 USA		fax:   (415) 493-4901
Xref: sparky bionet.neuroscience:641 sci.engr.biomed:687
From: venk@stein.u.washington.edu (Venkatesh Murthy)
Newsgroups: bionet.neuroscience,sci.engr.biomed
Subject: Re: motor unit action potential duration (repost)
Date: 13 Jan 93 04:27:44 GMT
Article-I.D.: shelley.1j05o0INN6ae
Distribution: world
Organization: University of Washington, Seattle
NNTP-Posting-Host: stein.u.washington.edu

In article <93012.181409BOYDJ@QUCDN.QueensU.CA> Jeff Boyd <BOYDJ@QUCDN.QueensU.CA> writes:
>
>I didn't receive any replies to this question;  in the hope that any
>interested parties may still have been away on holidays, I'm posting
>it again.
>
>>  I find myself needing a mathematical rule for determining the 'end'
>>  of a motor unit action potential.  For example, I could arbitrarily
>>  decide that a pulse is effectively over when, on its final phase, the
>>  amplitude has fallen to 1% of the peak-to-peak amplitude.
>>
>>  Is there a standard definition which has received general acceptance
>>  among EMG researchers?
>
>
>jeff
>

We record EMGs in our lab, but we've never had the need to define
the end of a single motor unit action potential; nevertheless, talking
to someone here who has worked with such things I gathered this much:

First of all, the motor unit action potential shape can be complex.
It can have several zero crossings or "turns".  If you do have a clean
signal, the best way to do what you want to is: 
	1. define a baseline (mean +/- sd) when there are no motorunits.
	2. then use some criterion such as "amplitude has fallen to within
	one standard deviation of baseline".  The tricky part will be to 
	see how many consistent "turns" you have in the action potential
	waveform and to see you include all such turns.

If you want to get more detailed, you can fit a regression line to the
last consistent "turn" in your action potential and determine where the
slope meets the baseline.  That would define your "end".

The bottom line seems to be that there is NO standard way of defining
this.  I'm assuming you need this so that you can isolate different
action potential shapes from the same electrode.  Let me know if you
need a better explanation of what I've just said and I'll try to 
provide one!  Also, be warned once again that I'm no authority on this!

-Venki Murthy
(venk@u.washington.edu)

PS: You may also wish to consult the literature on template matching
for action potential recognition - usually applied to neural recordings.
These days people use "fancy" methods such as wavelet analysis.
From: mitchm@casbah.acns.nwu.edu (Mitchell Maltenfort)
Newsgroups: bionet.neuroscience
Subject: Schizophrenia and the immune system
Date: 9 Jan 93 16:29:14 GMT
Distribution: usa
Organization: Northwestern University, Evanston Illinois.


	I was recently watching a PBS "Frontline" on schizophrenia, and was
struck by an idea when it was mentioned that schizophrenics have certain
white blood cell abnormalities.  Is it possible that schizophrenia is an
autoimmune disease?

	There is some precedent for this: myasthenia gravis is an autoimmune
disease in which the immune system targets the neurotransmitters that activate
muscle.  Might schizophrenia be the result of the immune system interfering
with the brain functions? 

	Although I have some basic knowledge of the nervous system, I don't
know as much about the specific condition of schizophrenia or the immune
system as I should to be able to evaluate this possibility.  I'm just posting
it to get some discussion going.  


Mitchell Maltenfort	Northwestern Unversity	Chicago, Illinois

mgm@nwu.edu		|:* Studying simulations or simulating studies *:|
From: turner@MATH.WISC.EDU (Robert Turner)
Newsgroups: bionet.neuroscience
Subject: (none)
Date: 9 Jan 93 00:21:18 GMT
Distribution: bionet

I would appreciate being sent information of the use of the
neurosciences network. Thank you
Professor Robert Turner
Department of Mathematics
480 Lincoln Drive
University of Wisconsin
Madison, WI 53706
turner@math.wisc.edu
Xref: sparky bionet.neuroscience:622 sci.engr.biomed:668
Organization: Queen's University at Kingston
Date: Tue, 5 Jan 1993 16:44:59 EST
From: Jeff Boyd <BOYDJ@QUCDN.QueensU.CA>
Newsgroups: bionet.neuroscience,sci.engr.biomed
Subject: motor unit action potential duration


I find myself needing a mathematical rule for determining the 'end' of a
motor unit action potential.  For example, I could arbitrarily decide
that a pulse is effectively over when, on its final phase, the amplitude
has fallen to 1% of the peak-to-peak amplitude.

Is there a standard definition which has received general acceptance
among EMG researchers?


jeff

Newsgroups: bionet.neuroscience
From: eepee@polaris.utu.fi (Esa-Pekka P{lvim{ki)
Subject: Re: Lastest on Halperidol?
Organization: University of Turku, Finland
Date: Mon, 4 Jan 93 14:45:58 GMT

In article <1992Dec26.013818.8234@ringer.cs.utsa.edu> senseman@lucy.brainlab.utsa.edu (David M. Senseman) writes:
>Haloperidol is a rather "old" dopamine blocker (=antagonist).
>As I understand it, it doesn't differentiate between D1 and D2
>receptors and in certain systems atleast, it has cross reactivity
>with serotonin. 

We've found (as have many others) that haloperidol has greater affinity for
and ability to block D2 receptors than D1, at least in the striatum. Chronic
haloperidol treatment also up-regulates D2 receptors. Whether the gene express-
ion is increased is yet controversial.

>The reason I'm asking? We recently did some experiments in which
>Haloperidol reduced a rather interesting neuophysiological process
>(maybe you'll read about it in Science?   :-)   Anyway, I would
>appreciate any info on Halperidol that the wizards on bionet.neuroscience
>care to share. 

I wonder what this process is...anyway, an interesting feature of haloperidol
is that it is a very persistent drug in the brain. While plasma concentrations
drop in hours, brain concentrations persist for days.

/ep

--
Esa-Pekka P{lvim{ki    eepee@utu.fi   "Mik{ vihelt{en tulee, se ujeltaen menee"
Dept. of Pharmacology, University of Turku, Finland		     -Doppler-
Xref: sparky bionet.neuroscience:633 fnet.ia:4
From: leroy@celio.greco-prog.fr (Guillaume LEROY)
Newsgroups: bionet.neuroscience,fnet.ia
Subject: DEA sciences cognitives ?
Date: 6 Jan 93 16:45:14 GMT
Distribution: fnet
Organization: ENSERB, University of Bordeaux, FRANCE.
Originator: leroy@celio




Bonjour,

	Je recherche activement les universites proposant des DEAs en
sciences cognitives. Je suis actuellement en troisieme annee d'ecole
d'ingenieur en informatique a Bordeaux et je souhaite m'orienter a la
rentree prochaine vers ce domaine. (Bordeaux n'a pas de DEA de ce genre
donc pas question de le en meme temps que la troisieme annee...)

	Je sais qu'il existe des DEAs a Paris (Orsay et Jussieu) et Grenoble,
on m'a recemment parle de Toulouse mais je n'ai aucune information a ce sujet,
de meme pour Nimes.

	Je souhaiterais donc recevoir des informations sur les universites qui
proposent ce type de DEA, la structure de l'enseignement (si possible!), ou
simplement la bonne adresse dans chaque universite pour obtenir ces
informations. (Autant pour celles citees que pour les autres). Si vous
pouviez meme me fournir des adresses de personnes a contacter dans des labos,
je serais satisfait.

				D'avance merci pour ce service,

						Guillaume LEROY



-------------------------------------------------------------------------------
Guillaume LEROY					leroy@celio.greco-prog.fr
				     o
			<============O ###0
				     o
E.N.S.E.R.B	Bordeaux France
-------------------------------------------------------------------------------
Xref: sparky bionet.neuroscience:639 sci.engr.biomed:685
Organization: Queen's University at Kingston
Date: Tue, 12 Jan 1993 18:14:09 EST
From: Jeff Boyd <BOYDJ@QUCDN.QueensU.CA>
Newsgroups: bionet.neuroscience,sci.engr.biomed
Subject: motor unit action potential duration (repost)


I didn't receive any replies to this question;  in the hope that any
interested parties may still have been away on holidays, I'm posting
it again.

>  I find myself needing a mathematical rule for determining the 'end'
>  of a motor unit action potential.  For example, I could arbitrarily
>  decide that a pulse is effectively over when, on its final phase, the
>  amplitude has fallen to 1% of the peak-to-peak amplitude.
>
>  Is there a standard definition which has received general acceptance
>  among EMG researchers?


jeff
From: aston@HAL.HAHNEMANN.EDU ("GARY ASTON-JONES, PH.D.")
Newsgroups: bionet.neuroscience
Subject: research associate
Date: 4 Jan 93 15:48:13 GMT
Distribution: bionet

Research Associate sought to record intracellularly from locus
coeruleus neurons in vitro and in vivo.  Strong experience with
intracellular and CNS in vitro techniques required.  Studies focus
on (i) afferent regulation of locus coeruleus neurons, (ii)
development of locus coeruleus and (iii) mechanisms of drug abuse
and withdrawal involving locus coeruleus.  Well-equipped,
dedicated lab among an interdisciplinary group of neuroanatomists,
neurophysiologists and behaviorists.  Extensive collaboration
potential.  Submission of grant applications for independent work
encouraged.  Submit vita to:
        Dr. Gary Aston-Jones
        Division of Behavioral Neurobiology
        Department of Mental Health Sciences
        Hahnemann University Medical School, M.S. 403
        Broad and Vine
        Philadelphia, PA 19102

Newsgroups: bionet.neuroscience