From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human matrix metalloproteinase-3 (MMP-3) mRNA, complete cds.
Date: 5 Nov 92 23:10:26 GMT
Distribution: bionet
Checksum: 00694 4

LOCUS       HUMMMP3A     1434 bp ss-mRNA            PRI       01-SEP-1988
DEFINITION  Human matrix metalloproteinase-3 (MMP-3) mRNA, complete cds.
ACCESSION   J03209
KEYWORDS    matrix metalloproteinase-3.
SOURCE      Homo sapiens synovium cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Saus,J., Quinones,S., Otani,Y., Nagase,H., Harris,E.D.Jr. and
            Kurkinen,M.
  TITLE     The complete primary structure of human matrix metalloproteinase-3:
            Identity with stromelysin
  JOURNAL   J. Biol. Chem. 263, 6742-6745 (1988)
  STANDARD  full automatic
COMMENT     Draft entry and computer-readable sequence for [1] kindly provided
            by J.Saus, 25-APR-1988.
FEATURES             Location/Qualifiers
     sig_peptide     1..51
                     /codon_start=1
     mat_peptide     52..1431
                     /product="matrix metalloproteinase-3"
                     /codon_start=1
     CDS             1..1434
                     /product="matrix metalloproteinase-3"
                     /codon_start=1
                     /translation="MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDL
                     EKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRT
                     FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIM
                     ISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAH
                     EIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVP
                     TEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWP
                     SLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAI
                     SDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFF
                     TGSSQLEFDPNAKKVTHTLKSNSWLNC"
BASE COUNT      391 a    325 c    337 g    381 t
ORIGIN      111 bp upstream of XbaI site.
        1 atgaagagtc ttccaatcct actgttgctg tgcgtggcag tttgctcagc ctatccattg
       61 gatggagctg caaggggtga ggacaccagc atgaaccttg ttcagaaata tctagaaaac
      121 tactacgacc tcgaaaaaga tgtgaaacag tttgttagga gaaaggacag tggtcctgtt
      181 gttaaaaaaa tccgagaaat gcagaagttc cttggattgg aggtgacggg gaagctggac
      241 tccgacactc tggaggtgat gcgcaagccc aggtgtggag ttcctgacgt tggtcacttc
      301 agaacctttc ctggcatccc gaagtggagg aaaacccacc ttacatacag gattgtgaat
      361 tatacaccag atttgccaaa agatgctgtt gattctgctg ttgagaaagc tctgaaagtc
      421 tgggaagagg tgactccact cacattctcc aggctgtatg aaggagaggc tgatataatg
      481 atctcttttg cagttagaga acatggagac ttttaccctt ttgatggacc tggaaatgtt
      541 ttggcccatg cctatgcccc tgggccaggg attaatggag atgcccactt tgatgatgat
      601 gaacaatgga caaaggatac aacagggacc aatttatttc tcgttgctgc tcatgaaatt
      661 ggccactccc tgggtctctt tcactcagcc aacactgaag ctttgatgta cccactctat
      721 cactcactca cagacctgac tcggttccgc ctgtctcaag atgatataaa tggcattcag
      781 tccctctatg gacctccccc tgactcccct gagacccccc tggtacccac ggaacctgtc
      841 cctccagaac ctgggacgcc agccaactgt gatcctgctt tgtcctttga tgctgtcagc
      901 actctgaggg gagaaatcct gatctttaaa gacaggcact tttggcgcaa atccctcagg
      961 aagcttgaac ctgaattgca tttgatctct tcattttggc catctcttcc ttcaggcgtg
     1021 gatgccgcat atgaagttac tagcaaggac ctcgttttca tttttaaagg aaatcaattc
     1081 tgggccatca gaggaaatga ggtacgagct ggatacccaa gaggcatcca caccctaggt
     1141 ttccctccaa ccgtgaggaa aatcgatgca gccatttcgg ataaggaaaa gaacaaaaca
     1201 tatttctttg tagaggacaa atactggaga tttgatgaga agagaaattc catggagcca
     1261 ggctttccca agcaaatagc tgaagacttt ccagggattg actcaaagat tgatgctgtt
     1321 tttgaagaat ttgggttctt ttatttcttt actggatctt cacagttgga gtttgaccca
     1381 aatgcaaaga aagtgacaca cactttgaag agtaacagct ggcttaattg ttga
//