From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Cavia porcellus progastricsin mRNA, complete cds.
Date: 4 Sep 92 10:03:13 GMT
Distribution: bionet
Checksum: 29342     4

LOCUS       GPIPROGAS    1351 bp ss-mRNA            ROD       04-SEP-1992
DEFINITION  Cavia porcellus progastricsin mRNA, complete cds.
ACCESSION   M88652
KEYWORDS    aspartic proteinase; pepsin; pepsinogen C; progastricsin.
SOURCE      Cavia porcellus adult cDNA to mRNA.
  ORGANISM  Cavia porcellus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Hystricomorpha; Caviidae; Caviinae.
REFERENCE   1  (bases 1 to 1351)
  AUTHORS   Kageyama,T., Ichinose,M., Tsukada,S., Miki,K., Kurokawa,K.,
            Koiwai,O., Tanji,M., Yakabe,E., Athanuda,S.B. and Takahashi,K.
  TITLE     Gastric procathepsin E and progastricsin from guinea pig:
            Purification molecular cloning of cDNAs, and characterization of
            enzymatic properties, with special reference to procathepsin E
  JOURNAL   J. Biol. Chem. 267, 16450-16459 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     misc_feature    1..1351
                     /note="cDNA insert in pGP461"
     CDS             43..1227
                     /EC_number="3.4.23.3"
                     /standard_name="pepsinogen C"
                     /product="progastricsin"
                     /codon_start=1
                     /translation="MKWMVVVLLCLPLLEATQIKVPLKKIKSIREVLREKGLLGDFLK
                     NHKPQHARKFFRNRLAKTGDFSVLYEPMSYMDAAYFGQISLGTPPQSFQVLFDTGSSN
                     LWVPSVYCSSLACTTHTRFNPRDSSTYVATDQSFSLEYGTGSLTGVFGYDTMTIQDIQ
                     VPKQEFGLSETEPGSDFVYAEFDGILGLGYPGLSEGGATTAMQGLLREGALSQSLFSV
                     YLGSQQGSDEGQLILGGVDESLYTGDIYWTPVTQELYWQIGIEGFLIDGSASGWCSRG
                     CQGIVDTGTSLLTVPSDYLSTLVQAIGAEENEYGEYFVSCSSIQDLPTLTFVISGVEF
                     PLSPSAYILSGENYCMVGLESTYVSPGGGEPVWILGDVFLRSYYSVYDLANNRVGFAT
                     AA"
     sig_peptide     43..90
                     /codon_start=1
     misc_feature    91..237
                     /note="propeptide"
                     /evidence=EXPERIMENTAL
     mat_peptide     238..1224
                     /EC_number="3.4.23.3"
                     /standard_name="pepsin"
                     /product="gastricsin"
                     /codon_start=1
BASE COUNT      246 a    439 c    380 g    286 t
ORIGIN
        1 cgggattcgg gtggtttctc tgaccgtctg ggaaccggca tcatgaagtg gatggtagtg
       61 gtcctgctct gcctgccgct cttggaggcg acgcagatca aggtccccct gaagaagatc
      121 aagtctatcc gggaagtcct gcgggagaag ggcctgctgg gggacttcct gaagaaccac
      181 aagccgcagc atgcccgcaa gttcttcagg aaccgcttgg ccaagactgg ggacttcagc
      241 gtgttgtatg agcccatgtc ctacatggat gctgcctact ttggccagat cagcctcggg
      301 acaccacccc agagcttcca ggtcctgttc gacaccggct cctccaacct gtgggtgcca
      361 tctgtctact gcagcagcct ggcctgcacc actcacaccc gcttcaaccc cagagattcc
      421 tccacctacg tcgccactga ccagtccttc tccctggagt acggcactgg gagcctcacc
      481 ggcgtctttg gctatgatac catgaccatc caagacatcc aggtccccaa gcaggagttt
      541 ggcctcagtg agacagagcc aggcagcgat tttgtgtacg ctgagttcga cggcatcctc
      601 ggcctgggct accccggcct gtcggaaggg ggcgccacca ccgccatgca ggggctgctg
      661 cgagagggcg ccctctccca atccctcttc agcgtctacc tgggcagcca gcagggttct
      721 gatgagggcc agctcatctt gggcggtgtg gacgagagcc tgtacacagg ggacatctac
      781 tggacacccg tcacccagga gctgtactgg cagattggca ttgagggctt cctcattgac
      841 ggctcagcct ccggctggtg ctcccgaggc tgccagggta ttgtggacac aggcacctcc
      901 ctgctcaccg tgccctcgga ctacctgagc accctggtcc aggccatagg ggccgaggag
      961 aacgaatacg gagagtattt cgtgagctgc agcagcatcc aggacctccc caccctgacc
     1021 ttcgtcatca gtggcgtgga gttccctctg tcgccatcag cctacatcct cagtggtgaa
     1081 aactactgca tggtggggct cgagagcacc tatgtgtccc ctgggggtgg cgagcccgtc
     1141 tggatccttg gagacgtctt cctgaggtcc tactactctg tctacgactt ggccaacaac
     1201 agggtgggct tcgccactgc tgcctagacg agctgcctgg accccggata ccttcccccg
     1261 tgggccccca gcttgtgcgg ctctccttcc tgggttcagc ccccaccttt cctggaccct
     1321 gaactttctc tcttaataaa tagttctcca c
//