From: Billi Goldberg <bigoldberg@igc.apc.org>
Subject: Updated DNCB Treatment Instructions
Note: Copyright 1992, Dan R. Greening. Non-commercial reproduction allowed.
Archive-Number: 6167
Organization: unspecified
Date: Sat, 12 Sep 92 11:48:12 PDT

                     DNCB TREATMENT INSTRUCTIONS

DESCRIPTION 

DNCB (dinitrochlorobenzene) is a simple organic compound easily made by 
chemists. It is an unpatentable and inexpensive substance that is usually 
obtained in either bulk crystal form or liquid form (in an acetone base) from 
chemical supply houses. In industry, DNCB is used in the processing of color 
photography. It is also in use as an algicide in air conditioners and 
refrigeration equipment.

In past decades, researchers discovered dermatological uses for DNCB that 
involve direct application to the skin. In the process of exploring the 
dermatological applications of DNCB, researchers also discovered that DNCB has 
a very low toxic risk.

DOSAGE AND ADMINISTRATION 

For dermatological purposes, DNCB is currently available in four solution 
strengths, namely 10%, 2%, 0.2% and 0.02%. Each solution has an acetone base.

The stronger 10% solution is used initially in very small amounts to sensitize 
the body to DNCB. The weaker 2%, 0.2% and 0.02% solutions, which are applied 
using a cotton swab and accommodate differences in sensitivity, are intended 
for ongoing applications.

ACTION 

The mechanism of DNCB is similar to that of poison oak. Both produce a redness 
or itching of the skin indicative of contact dermatitis, as well as an 
underlying bodily effect.

ADVERSE REACTIONS  

Depending on the solution strength, DNCB may cause either a strong or mild 
form of contact dermatitis at the application site. The stronger, sensitizing 
10% solution may cause a more noticeable itchiness, tingling, burning or 
redness within hours of application. The weaker 2%, 0.2% and 0.02% solutions 
cause a much milder skin reaction similar to the redness experienced from 
sunburn.

WARNINGS AND PRECAUTIONS 

1. Use only the 10% solution for sensitization unless a dermatologist 
   knowledgeable in contact sensitization recommends differently.

2. If severe contact dermatitis occurs, apply itch-reducing medicines 
   (e.g. calamine lotion) or Bactine directly to the rash. The use of 
   cortisone or hydrocortisone creams is not recommended for the itching.

3. If severe blistering occurs at an application site during sensitization,
   stop further applications and treat the blistering like any other minor 
   abrasion. Use Bactine or another topical antibacterial medication. Once the
   skin heals, resume applications using a lower concentration.

4. Avoid sunbathing or sustained exposure to the sun while using DNCB. 
   The absorption of the sun's rays by the skin may inhibit the intended 
   reaction.

5. Do not apply DNCB directly to any kind of topical skin disease or 
   disorder, such as Kaposi Sarcoma (KS) lesions.

6. If DNCB has been previously used or the skin exposed to DNCB (for 
   example, while developing color photography), do not use the 10% 
   solution for initial sensitization. Use the weaker 2% solution or 
   consult a dermatologist
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