From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mRNA for IgM heavy chain complete sequence
Date: 10 Apr 92 10:06:24 GMT
Distribution: bionet
Checksum: 38901     7

LOCUS       HUMIGM201    2213 bp ss-mRNA            PRI       10-APR-1992
DEFINITION  Human mRNA for IgM heavy chain complete sequence
ACCESSION   X17115
KEYWORDS    IgM gene; IgM heavy chain; immunoglobulin heavy chain;
            transmembrane protein.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2213)
  AUTHORS   Friedlander,R.M.
  JOURNAL   Unpublished (1989)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 2213)
  AUTHORS   Friedlander,R.M., Nussenzweig,M.C. and Leder,P.
  TITLE     Complete nucleotide sequence of the membrane form of the human IgM
            heavy chain
  JOURNAL   Nucleic Acids Res. 18, 4278-4278 (1990)
  STANDARD  full automatic
COMMENT     SWISS-PROT; P01871; MUC$HUMAN. SWISS-PROT; P20769; MUCM$HUMAN.
            *source: tissue=lymphoid; cell type=B; cell line=lymphoma 201;
            *source: clone=201-203; For genomic sequence see <K01306>,<X14939>
            and <X14940>. The author reports various conflicts with these
            sequences.
            Data kindly reviewed (30-MAY-1990) by Friedlander R.M.
            From EMBL 27   entry HSIGM201;  dated 26-JUL-1990.
FEATURES             Location/Qualifiers
     misc_feature    1..39
                     /note="putative VECTOR sequence BlueScribe (X52329,
                     X52331)"
     CDS             73..1956
                     /note="precursor (AA -15 to 612)"
                     /codon_start=1
                     /translation="MDWTWRFLFVVAAATGVQSQVQLVQSGAEVKKPGSSVKVSCKAS
                     GGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMEL
                     SSLRSEDTAVYYCAKTGILGPYSSGWYPNSDYYYYGMDVWGQGTTVTVSSGSASAPTL
                     FPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYA
                     ATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFF
                     GNPRSKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTST
                     LTIKESDWLSQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKS
                     TKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNS
                     GERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTG
                     FSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTC
                     VVAHEALPNRVTERTVDKSTEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLF
                     KVK"
     CDS             73..114
                     /note="leader peptide (AA -15 to -1)"
                     /codon_start=1
                     /translation="MDWTWRFLFVVAAA"
                     /partial
     CDS             118..1956
                     /note="IgM heavy chain (AA 1 to 612)"
                     /codon_start=1
                     /translation="GVQSQVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQA
                     PGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAK
                     TGILGPYSSGWYPNSDYYYYGMDVWGQGTTVTVSSGSASAPTLFPLVSCENSPSDTSS
                     VAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQG
                     TDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRSKSKLICQATG
                     FSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLSQSMFT
                     CRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDS
                     VTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPS
                     PLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQ
                     PLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERT
                     VDKSTEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK"
                     /partial
     polyA_site      2213
                     /note="polyA site"
BASE COUNT      462 a    708 c    629 g    414 t
ORIGIN
        1 gctctagaac tagtggatcc cccgggctgc aggaattctc taaagaagcc cctgggagca
       61 cagctcatca ccatggactg gacctggagg ttcctctttg tggtggcagc agctacaggt
      121 gtccagtccc aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg
      181 gtgaaggtct cctgcaaggc ttctggaggc accttcagca gctatgctat cagctgggtg
      241 cgacaggccc ctggacaagg gcttgagtgg atgggaggga tcatccctat ctttggtaca
      301 gcaaactacg cacagaagtt ccagggcaga gtcacgatta ccgcggacga atccacgagc
      361 acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg
      421 aaaaccggga tcctggggcc gtatagcagt ggctggtacc cgaactcgga ctactactac
      481 tacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctcagg gagtgcatcc
      541 gccccaaccc ttttccccct cgtctcctgt gagaattccc cgtcggatac gagcagcgtg
      601 gccgttggct gcctcgcaca ggacttcctt cccgactcca tcactttctc ctggaaatac
      661 aagaacaact ctgacatcag cagcacccgg ggcttcccat cagtcctgag agggggcaag
      721 tacgcagcca cctcacaggt gctgctgcct tccaaggacg tcatgcaggg cacagacgaa
      781 cacgtggtgt gcaaagtcca gcaccccaac ggcaacaaag aaaagaacgt gcctcttcca
      841 gtgattgctg agctgcctcc caaagtgagc gtcttcgtcc caccccgcga cggcttcttc
      901 ggcaaccccc gcagcaagtc caagctcatc tgccaggcca cgggtttcag tccccggcag
      961 attcaggtgt cctggctgcg cgaggggaag caggtggggt ctggcgtcac cacggaccag
     1021 gtgcaggctg aggccaaaga gtctgggccc acgacctaca aggtgaccag cacactgacc
     1081 atcaaagaga gcgactggct cagccagagc atgttcacct gccgcgtgga tcacaggggc
     1141 ctgaccttcc agcagaatgc gtcctccatg tgtgtccccg atcaagacac agccatccgg
     1201 gtcttcgcca tccccccatc ctttgccagc atcttcctca ccaagtccac caagttgacc
     1261 tgcctggtca cagacctgac cacctatgac agcgtgacca tctcctggac ccgccagaat
     1321 ggcgaagctg tgaaaaccca caccaacatc tccgagagcc accccaatgc cactttcagc
     1381 gccgtgggtg aggccagcat ctgcgaggat gactggaatt ccggggagag gttcacgtgc
     1441 accgtgaccc acacagacct gccctcgcca ctgaagcaga ccatctcccg gcccaagggg
     1501 gtggccctgc acaggcccga tgtctacttg ctgccaccag cccgggagca gctgaacctg
     1561 cgggagtcgg ccaccatcac gtgcctggtg acgggcttct ctcccgcgga cgtcttcgtg
     1621 cagtggatgc agagggggca gcccttgtcc ccggagaagt atgtgaccag cgccccaatg
     1681 cctgagcccc aggccccagg ccggtacttc gcccacagca tcctgaccgt gtccgaagag
     1741 gaatggaaca cgggggagac ctacacctgc gtggtggccc atgaggccct gcccaacagg
     1801 gtcaccgaga ggaccgtgga caagtccacc gagggggagg tgagcgccga cgaggagggc
     1861 tttgagaacc tgtgggccac cgcctccacc ttcatcgtcc tcttcctcct gagcctcttc
     1921 tacagtacca ccgtcacctt gttcaaggtg aaatgatccc aacagaagaa catcggagac
     1981 cagagagagg aactcaaagg ggcgctgcct ccgggtctgg ggtcctggcc tgcgtggcct
     2041 gttggcacgt gtttctcttc ccgcccggcc tccagttgtg tgctctcaca caggcttcct
     2101 tctcgaccgg caggggctgg ctggcttgca ggccacgagg tgggctctac cccacactgc
     2161 tttgctgtgt atacgcttgt tgccctgaaa taaatatgca cattttatcc atg
//