From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human lamin B2 mRNA, complete cds.
Date: 30 Jul 92 10:01:16 GMT
Distribution: bionet
Checksum: 28612     8

LOCUS       HUMLAMB2A    4270 bp ss-mRNA            PRI       30-JUL-1992
DEFINITION  Human lamin B2 mRNA, complete cds.
ACCESSION   M94362
KEYWORDS    lamin B2.
SOURCE      chromosome 19
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4270)
  AUTHORS   Biamonti,G., Giacca,M., Perini,G., Contreas,G., Zentilin,L.,
            Weighardt,F., Guerra,M., Valle,G.D., Saccone,S., Riva,S. and
            Falaschi,A.
  TITLE     The gene for a novel human lamin maps at a highly transcribed locus
            of chromosome 19 which replicates at the onset of S-phase
  JOURNAL   Mol. Cell. Biol. 12, 3499-3506 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     exon            1..669
                     /note="this gene is strictly associated with a genomic
                     replication origin"
                     /note="undefined"
                     /gene="lamin B2"
                     /partial
     CDS             298..1548
                     /product="lamin"
                     /gene="lamin B2"
                     /codon_start=1
                     /translation="MRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSS
                     RQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAARE
                     ELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEM
                     RDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEESLKLSPSPSSRVTVSRATSSS
                     SGSLSATGRLGRSKRKRWRWRSPWQRPKRPGHGHGWQRWLPPGPAGLGLGQRHIEEID
                     LEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGV
                     AHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEA
                     EFGEEDLFHQQGDPRTTSRGCYVM"
     exon            670..891
                     /note="defined"
                     /gene="lamin B2"
     exon            892..1275
                     /note="undefined"
                     /gene="lamin B2"
     rep_origin      991..1008
                     /function="nuclear localization signal pep: KRKRWR"
                     /gene="lamin B2"
     exon            1276..1395
                     /note="defined"
                     /gene="lamin B2"
     exon            1396..1506
                     /gene="lamin B2"
     exon            1507..4270
                     /note="last"
     3'UTR           1549..4270
                     /gene="lamin B2"
     polyA_signal    4265..4270
                     /gene="lamin B2"
BASE COUNT      884 a   1193 c   1372 g    821 t
ORIGIN
        1 agagtcctgg atgagacggc tcgagagcgt gcccggctgc agatagagat tgggaagctg
       61 agggcagagt tggacgaggt caacaagagc gccaagaaga gggagggcga gcttacggtg
      121 gcccagggcc gtgtgaagga cctggagtcc ctgttccacc ggagcgaggt ggagctggca
      181 gctgccctca gcgacaagcg cggcctggag agtgacgtgg ctgagctgcg ggcccagctg
      241 gccaaggccg aggacggtca tgcagtggcc aaaaagcagc tggagaagga gacgctgatg
      301 cgtgtggacc tggagaaccg ctgccagagc ctgcaggagg agctggactt ccggaagagt
      361 gtgttcgagg aggaggtgcg ggagacgcgg cggcggcacg agcggcgcct ggtggaggtg
      421 gacagcagcc ggcagcagga gtacgacttc aagatggcac aggcgctgga ggagctgcgg
      481 agccagcacg acgagcaagt gcggctctac aagctggagc tggagcagac ctaccaggcc
      541 aagctggaca gcgccaagct gagctctgac cagaacgaca aggcggccag tgcggctcgc
      601 gaggagctga aggaggcccg catgcgcctg gagtccctca gctaccagct ctccggcctc
      661 cagaagcagg ccagtgccgc tgaagatcgc attcgggagc tggaggaggc catggccggg
      721 gagcgggaca agttccggaa gatgctggac gccaaggagc aggagatgac ggagatgcgg
      781 gacgtgatgc agcagcagct ggccgagtac caggagctgc tggacgtgaa gctggccctg
      841 gacatggaga tcaacgccta ccggaagctc ctggagggcg aggaggagag cctgaagctg
      901 tcccccagcc catcttcgcg cgtcaccgtc tcacgagcca cctcgagcag cagcggcagc
      961 ttgtccgcca ccgggcgcct gggccgcagt aagcggaagc gctggaggtg gaggagccct
     1021 tggcagcggc ccaagcgtcc tgggcacggg cacgggtggc agcggtggct tccacctggc
     1081 ccagcaggcc tcggcctcgg gcagcgtcac atcgaggaga tcgacctgga gggcaagttt
     1141 gtgcagctca agaacaactc ggacaaggat cagtctctgg ggaactggag aatcaagagg
     1201 caggtcttgg agggggagga gatcgcctac aagttcacgc ccaagtacat cctgcgggcc
     1261 ggccagatgg tcacggtgtg ggcagctggt gcgggggtgg cccacagccc cccctcgacg
     1321 ctggtgtgga agggccagag cagctggggc acgggcgaga gcttccgcac cgtcctggtt
     1381 aacgcggatg gcgaggaagt ggccatgagg actgtgaaga agtcctcggt gatgcgtgag
     1441 aatgagaatg gggaggaaga ggaggaggaa gccgagtttg gcgaggagga tcttttccac
     1501 caacaggggg acccgaggac cacctcaaga ggctgctacg tgatgtgaac ccacactcct
     1561 catccacaca cctttcttta cccagagcca ctgaaaacta ttttttatca ttggctttct
     1621 ttagttcttg atacatttct agagaatttc taagcgaact gccagaacgt gtgggtgggt
     1681 ctcccccagc cctccctcct ggcgggtctc ctccagcctc acttcgctgc cacttcgccg
     1741 ctgccccgga gacttttcaa tcccacccca ctcctcatct caccatttgg tcaaattgga
     1801 agcccagggc caggacccgg aggtttagaa gatgcttggg cttggaggga ggagggccgg
     1861 cgaggctagc gaggggacag gagacggccc tgctgcggac ggagcgcgga aactgcgtag
     1921 gaattcagtg gtggtgggtt tttttaaggc tttctacaaa accaaattca gaatccaggc
     1981 gtcgacctgg tggggcccgg ggcaagcctg cattctggct gcccagcttc ggacagcggg
     2041 aactcctcag gcagccacgc agcgggtgtg ggccagcatg gggatggcgt ggccccaggg
     2101 gggttttcac tccgctgcct gggcttccag attcccgttc tggcagcgac cggccgggtt
     2161 tctcggaccg ttgactttat ttgggggagt tttcccgcag ttcagttcct gactgtgcaa
     2221 ggccaacagg gcaggggagg ggaagacctg gggaaggaag aatgaggaca cagtcccgtc
     2281 gtaagacctg tcacaacaat aagcagggag gggagatgtg gaggggacac atctggttgc
     2341 cttggaggca gaagctgtga gtttcagaac agctgtctgc agggaacgcc accatgttga
     2401 ccctctggag gagagcgctg tggagcccct cccgtgttcc agctccgtct gccctgtgcc
     2461 tatatatcac atgcgtctat catactgtgt ctttatctgt gatttttctc gctgaaacat
     2521 gtttctcaga cagccaaggc cacctgactc ctatcacgac gcacccaagc ccctcagtcc
     2581 agcttcccaa tgcctggcac ccccttcggc aatagctcac cgtttacacc ctccctcata
     2641 gatacacaga agttattttt ttaatggata tttatttttt tacattggtc agtacacagg
     2701 tcagggagct cacgccaggg ccttgaggac aggctgaccc tcctccccgg ggtggcgtgg
     2761 ggctggggca cccccgacgg cagagcctcc ttcagaaagt gcagctcaag tcttaaagac
     2821 accaaaactg agccatgggc acgcgccgtc tccgggccat ggcgttcact gcagggcggg
     2881 ggcggcaccg ctcccctgtg actgcatccc gcctccctgg ggacctgcct gtggcaggaa
     2941 ggaatggggg gccccagccc aggccgggaa ggagccagcg gccgacaaag cagaaacacc
     3001 gctgctccac gtagcccctg ctggctgtcc ttgctctcag aagtcccggt cccatgtaga
     3061 tagagcccgg cggatcttac caaagcattt cctcctggag gctacgccgc ttggtgctcc
     3121 cagtgaggcg gctggtaggg agctttgcct gccccgggga taccctctac cagccgctgg
     3181 aagtgggaat gctggcgaca gactgtgtct gtttcccacc ttcatagcag gaatcacccg
     3241 gacccgactg gctgggcttc gtgctagcga gggttttctg ggggtgggtc ttggtgatct
     3301 tgtcctatgg ggatctctgc agtggtctca gccacatcct agtatatttt ggctctggag
     3361 gagcaaagct gtatcctgga gttggtctgt gatttgccga cagacttgca ggctgggctc
     3421 agcaaagtcc cccccaaaac ccgcaggtcc tcatgtccag acgctgccag tcctgtcctg
     3481 aaaacagcac gccccaggcc cacagaaccc cccaccctac atttgccttg ggtggagctg
     3541 ggggtggtcc taggactgcg ggtgccctta gctgaagggg gcccgcagaa gcgtgagctg
     3601 ggccgcctgt gggtcattgg aggttcattg agaattgagt cctttggaaa gactaagaaa
     3661 atcaaatttt taaaagttat ttatggcctg ggaaacaatt tgcatttgtc cccaaatacg
     3721 cttagctgtg tgccgcttag aacgatgaga aaccatccct ctgtgtaagc ccgtgccgtg
     3781 tgactcgaag cctagcgccc tccctgcgaa gcatcagacg ccacccagcc ctgggggagg
     3841 cccacgcctg ctggaccaac gcgggttctg gggtgcacag cgccaggtta acgctgaagc
     3901 ctgccccgct gagcccaaga gccgggaggc ctgcgggctg acccagaatc cgatcatgca
     3961 cctgtcctca tgccagcggc tttggctggg gttggtctga agcctgcacg cggcagttct
     4021 ttgttaaaga tctgagggac tcgtcagtcc tagcgtcgcc gcctgcagcc tcttccaagc
     4081 cctgcgtcca gcgagcgtca cagcacaacc tgcaaaaacg gagctgggct gcagctgggg
     4141 ctggcatgga ctttcatttc agagattcgg tttttaagaa gatgcatgcc tagcgtgttc
     4201 tttttttttt ccaatgattt gtaatataca ttttatgact ggaaactttt ttgtacaaca
     4261 ctccaataaa
//