From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human histatin 1 (HIS1) gene exons 1-5, complete cds.
Date: 6 Nov 92 18:06:37 GMT
Distribution: bionet
Checksum: 26863 12

LOCUS       HUMHIS102    7550 bp ds-DNA             PRI       28-OCT-1992
DEFINITION  Human histatin 1 (HIS1) gene exons 1-5, complete cds.
ACCESSION   L04132
KEYWORDS    histatin 1; salivary protein.
SEGMENT     2 of 3
SOURCE      Homo sapiens (individual_isolate individual J.F.) (library: lambda
            Charon 40) DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 7550)
  AUTHORS   Sabatini,L.M., Ota,T. and Azen,E.A.
  TITLE     Nucleotide sequence analysis of the human salivary protein genes
            HIS1 and HIS2 and the evolution of the STATH/HIS gene family
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     sig_peptide     join(4013..4063,5258..5263)
                     /gene="HIS1"
                     /codon_start=1
     mat_peptide     join(5264..5278,5357..5386,6434..6502)
                     /product="histatin 1"
                     /gene="HIS1"
                     /codon_start=1
     exon            1375..1432
                     /number=1
                     /gene="HIS1"
     intron          1433..3999
                     /number=1
                     /gene="HIS1"
     exon            4000..4063
                     /number=2
                     /gene="HIS1"
     intron          4064..5257
                     /number=2
                     /gene="HIS1"
     exon            5258..5278
                     /number=3
                     /gene="HIS1"
     intron          5279..5356
                     /number=3
                     /gene="HIS1"
     exon            5357..5386
                     /number=4
                     /gene="HIS1"
     intron          5387..6433
                     /number=4
                     /gene="HIS1"
     exon            6434..6538
                     /number=5
                     /gene="HIS1"
     CDS             join(4013..4063,5258..5278,5357..5386,6434..6505)
                     /gene="HIS1"
                     /product="histatin 1"
                     /codon_start=1
                     /translation="MKFFVFALVLALMISMISADSHEKRHHGYRRKFHEKHHSHREFP
                     FYGDYGSNYLYDN"
BASE COUNT     2427 a   1285 c   1184 g   2651 t      3 others
ORIGIN      
        1 ttttatttta ctttcctatt ttactttaag ttctgggata cgtgtgcaga acatgcagat
       61 ttgttgcatt ggtaaacgtg tgccatggtg gtttgctgca cctatcaacc catcatctag
      121 gttttaancc ccacatgcat tagctatttg ccctgatgct ctccctccct nncccaccac
      181 caggccctgg tggcgttgtt tccttccctg aatcagacac aaatttaaaa cataatttct
      241 aattagtggg atcaagctaa agaccatgcg tttataaatc tcttaagtag tttttctatc
      301 tttaaagtac acaaagagtc tcctggacat gttcttaaaa ttccggttcc aggtgtacac
      361 cacaagattc tgactcagta agtttggaaa agtagaataa gaatctgcat ttcaacagct
      421 actagctgat gctgatcatg atggtcgcat gtggcaccct ctgaggaaca atggactggg
      481 ctgtataact tatctgaact ttagaaaaga gtttttaata ctcagttctt agcacatcaa
      541 attctccaac cggtagagag taggtgaatg cttatacatg tttgcctatg aattaaatta
      601 aaattctgtt tttctctttc tgtctaatat agttatttca acaaatggcc tctataaata
      661 tatatgaacc tcagaaaact ccagggaagt aaattcaaat ttctaaacat aagaaatcag
      721 ttttatgtga gagatatgtg accaagcacc tagaatcttt tgacattaaa tatgagaatg
      781 tttttatcat atgatatcca aaagatgatt gaattttggc aaatgtttac attcacttta
      841 ttacttaaaa cactcaaagt caatgtaaag gtaaaaatac aagataaata atgatttgta
      901 ggaaaacttt tgaagtatag aatgactcca attttattat gccaattatc actatttact
      961 agagaatgtg taaaattttg ataacatggt aagtatattt ttgacatagc gttggttcca
     1021 tcttggacat atatttgttg aaaagtagta agatggtatt ctacagaaac atctttatca
     1081 ctgcaatcat ttctatgcct ggtttcctcc agcgtgcttt tccgttgtct gactcactca
     1141 gggctagact aacactggga ttagcatgtg atgggtccat tcgctttccg gttgctttgt
     1201 cttcacaatg atctattgta aaatcacctg gttaagttta tttttagaat ttgtagagac
     1261 agattttggg cattactttc cgtctcaatc atatgatctc ctaattgatg ctatttagaa
     1321 aaacaaaagg gagatttcaa cgtgtttaaa tacatcagcc atatagaaaa ggacatctct
     1381 tgagacttca cttcagcttc actgacttct tgactctcct cttgagtaaa aggtaatatg
     1441 ttcaagtaca atctaatatt atatattagc ataagctttt gtttgctaaa atcaatagta
     1501 accccactta tgaaaatgta tattatctat ttaaatctag tttacttgaa ttgcgtattt
     1561 gcctaaataa ataatttaca tttttgtata ttacctatag aataccataa tttctaatag
     1621 gactgttcaa attagcatag atgatttatc taataaatat ttcctttaaa aactcacaca
     1681 caaattcatt ttattttatt ttattttact ttcttatttt actttaagtt ctgggatacg
     1741 tgtgcagaac atgcagattt gttgcattgg taaacgtgtg ccatggtggt ttgctgcacc
     1801 tatcaaccca tcatctaggt tttaagcccc gcatgcatta gttatttgcc ctgatgctgt
     1861 aatgtgtaca attttgtact cgggatctga agatgacttc cagatctcaa ttcctatgaa
     1921 ttaacaccag caatcatcac gcaaagtaaa ttatgtggaa tatggcaatg tattacatcc
     1981 tctctgatgg tgggacctca attaactctt tttatttcct tgtctagata cctaatatct
     2041 actttcttaa ttattaattc tacatttaac ttaaagcagg agttcaaatt ttacaagaag
     2101 atactgataa attctctctg gtaaatatat tattataaag gtttattttt aaaaatttac
     2161 tttcttctta ataggaaact attttattac ttttttattg acctttccat catttaaaac
     2221 agtgctgtta taatgcaaag catatactgt ataagagttt agtcatctca atcttactaa
     2281 tttgtttaac tcattttcat tcatttgtgt tatggcagaa aagaaagagt ttactgttcc
     2341 aaatttttat tgatgtgtta cttgggaaat atgtttttca taaccattaa ttgtatattg
     2401 attatctatg ttcatttatc tatcagttta tgtgttagta aaagaagacc aatttcttag
     2461 aacccttttt tattttgtac ttgcaacaga attgacaatc attaacaaca gtaaaattct
     2521 catgcctttt gtatcataaa aagagttgta gtaggattta tatattaggt aatagaaaaa
     2581 cttcaaaata cataattttt atagttagtc ctatagtaga agtttccatt taaatgagtg
     2641 aagcaaaatg aacgaataaa taatatggta aatgccataa atcttgggtt ctgcttttca
     2701 tgatagagat gtagggctgt ttaagagcag acattttatt ataattagat gaaaaatgtt
     2761 actgtaatgt tatatcacaa atgacaggaa agagagatta gaaaaaaatt tttaaattac
     2821 ctattaatga attactttat aactgcaatt aacagccaaa aatgccatgt aactgtaagt
     2881 cttgtggtaa ttgtattttc caatggaaat gcttttattt acgtttgtaa tttagaaata
     2941 agtaacctgc tatacttttt tatatctgca aaggaactgg atacacttgc atatacataa
     3001 ttataaaagc atatcagagt cccagatgag gctaactttg ttgaataata ttatttgaaa
     3061 tattgaataa tcttcaccag ttcaacttct caaagtagat acaatcattt tccctgtgaa
     3121 ttctcttcat tttatttttc gctacccaat atcactaatg ttctaatctc agggttacac
     3181 cttctgtgga ttctgtaata gaactctggc tcatagtcac tgactttatt ataaagccag
     3241 tctccattgc ttttcattct actttcctaa tatctcttta cactgtacct taattagcat
     3301 tcttaatgtc attatataag tcccctgtag tgtcacaaca acctaagtgg tcatcttttc
     3361 tccagttttg tcctccctat gtgttgaact gtttgcattt ttaacatgct ttcctctctg
     3421 ttttatttct ttataggctc ccaacaccac cctttactca ttccatataa tccaactcaa
     3481 gcttgccttt cttcattacc ttcttactcc catcctcttg gtctgtttaa gatgtccatt
     3541 tgtgtgtttc attagcatat taatatttcc aaatcagagc actcaccttt acttatcaat
     3601 tcatgaggcc atgctggggc tcacacctgt aatccaagca ttttgagaag acaaggcagg
     3661 aagattccta gagcccagga gtttcagaac tgcctgggaa atatagtgag actaaaaaca
     3721 ttctctacta aaaaaaaaaa aaagaaagaa aaaattcgct gggcatggtg gcacacactt
     3781 gtagttccag ctacaagtgg gactagggag gctaaggtgg gaggatggct tgagaccaga
     3841 tggtccaggc tgcagtgatc tgtgctcatg cccctgcact ccagcctgga aaacagagca
     3901 tgtctcccaa tgctttgaag catagtgtca tcaatggaag tttgatgaat gaatgcatga
     3961 aagaatgtga ttactgattt ttcatgtttg attttatagg actcagccaa ctatgaagtt
     4021 ttttgtcttt gctttagtct tggctctcat gatttccatg attgtaagta tatctggaaa
     4081 ttttaaatac tacattctca gtacttatcc caagtgtctc tcttattcct tgtgttctgg
     4141 tatatactca tgttgacctc aatacagctt tataagcttt aatatttccc tacaaggagt
     4201 ttctttgaat taacttatgt aagttcttta aggacttgga atagatattc atcacatacc
     4261 tacaaacact caagtacaat tacttgaatg taaaagtaaa agaaaattta gcgagctttt
     4321 taaatatgtg ggactaagat ctgtgaaagt atctttaaat gtgaaaagct ctagaccatc
     4381 tgaagttaga aatctgagga aagaaaaagg tgcacttcaa tggaacccaa gtattagagg
     4441 gtgtcaaaat aggaattttc aagtcatttc ttgcacaacc tactcttaaa gtcagcatac
     4501 aattatttaa ttcttcctaa aataaagctg cttattttaa accataaaac aaatctccat
     4561 atttattaag tgtcatgagt tcccagctct attgtcattt actactgtgt attagtagga
     4621 aaagcacttg acctctttgg agctctttct ccttctctac ttccaccgcc tcttcctcct
     4681 cctcctcctc ctcctctttc tatgaactta atagaaaatt ggtcacaaaa gaataataat
     4741 actccaaact atccactaaa ttctaatgaa tgtttcgaaa ctgaattggt tatgatatca
     4801 cagtttatca cgtgatttta ttataaaagg atagaagtag aaaaataaac aaataagaac
     4861 agagtaaagc ataatgcctg tctctatcag caaataaaat atttgtatgt tggtagcttt
     4921 tgagctacat ggaacatatt catataaaaa acaatccaga gtttcatttt tcagtttcca
     4981 ctctcttatt caccactgac agacttttcc tgccttacat aaaaaagata tataaaccaa
     5041 aatgagttga tatttgaata tagcacatta attatagcat ttacccctca ctcattttga
     5101 agatgtcata aagctaaaat aactaattta gtctgtcatc aaccaaagaa tgcctccatt
     5161 ctgtttaatc atatatgtgg ctaagtcaat atttatactt actcttgaat tataaaatta
     5221 aaatattaat tattttctca ttttcttttt ttccaagagc gctgattcac atgaaaaggt
     5281 aagacatttt catttacggg aaaacttgat aaataaacat atattgaatt tttaatcttt
     5341 tctttttatt tcatagagac atcatgggta tagaagaaaa ttccatgtaa gtgttcttct
     5401 gataatgtgc actctaaata aattttcctc tctgactatt tattctccta gaagaatcaa
     5461 tagttgtctc tcaaatatat ctatatcatt aattgctaaa gtgcacattg atttcattta
     5521 tttatgatgc aaaggcaaaa agtcacaaat atcttgtgtc ctaaaagcat ttcaacagaa
     5581 actcaattcc acctgagata agtcaattgt caattatgct ctgagaactt atctttgtcc
     5641 tgtaaataat ttcattgacc taaagaatag ttgaaatcct aattctatta agtataacat
     5701 atgcttaata aagcatagag gctactcatg taatgtggta agtttctacc ttctgaattt
     5761 ttgaggatga tacagtcttt aaattaaact gactgtgcta aattagacag aaaattgtat
     5821 ttctctaaca tttttctcac tgtatgtata taaagtctca tgttattttg acctgtaata
     5881 tcaatatgaa tctgggttct aaagttctcc ttactaacat agcaagtata catgttaaaa
     5941 aagcaccaag taaaaagatg cataaaaatg gatgaagact gtttgtgtta acagcagtgg
     6001 gtatgaaaga atgtaggagt tgtaaaggaa agtaagatca ctaaaggaat gacattaaga
     6061 agcaccacct aagttggaaa cagtaactta atcctttcca taatactcaa tagtgagcaa
     6121 aatagtagct tggaggtaat attttaaaga agatttgaac cctggttaga gaggttacct
     6181 ataatcagtg tttccacctg tgctattgtc acaaaaatat cagcaaacag taaatacttt
     6241 atcattttta cctactttta gacatttttc tgataaaaaa gaaaaatgta aaagtttgaa
     6301 aacatttatg tagataaaat acaaggtctt aacaacttta gcaatctaag cttttaatga
     6361 cagtttttga gaaacacttg tactgtcatt ctctattctc tgcaatttgc tctctccttt
     6421 tgtgtgtatg caggaaaagc atcattcaca tcgagaattt ccattttatg gggactatgg
     6481 atcaaattat ctatatgaca attgatatcc ttagtaatca tggggcatga ttatagaggt
     6541 aagctgactc tagttacttg tctttctaga agtgtcaaca ctgacagttt aaaaaaaaag
     6601 ccataagcta acaaccattc cagtttaaga aatgtagcat gggttagctc cttgaagtgt
     6661 attcatttgt ataaatgctt ctgaagctgt agatatgtgg tgttatttct gaggtctctg
     6721 ttctgtgcca ttggtctgta tgttgttttg gtactggtac catgctgttt tggtaactgt
     6781 agctttgtag tatagtttga agtcaggtag tgtgatgcct tcagctttgt tcttttgctt
     6841 acaattgtct tgggtatatg agcttttctt tggatccata tgaaatttaa agtagttatt
     6901 tctaattctg tgaagaatgt caatggtcat ttgatgggaa tagcattgaa tctataaatt
     6961 actttgatca gtatggccat tttcatgata atgatttttc ttatccatga gaatggaatg
     7021 tttttccatt tgtttgtgtc ctttcttatt tccttgagca gtggtttgta gttctccttg
     7081 aagaggtcct tcacatcctt tgttagctgt atttctaggt attttattct ctttgtagca
     7141 attgtgaatg ggagttcatt catgatttgg gtctctgctc gccatctgat attcaacaaa
     7201 cctgacaaaa caagtaatca agaaaggatc tcctattgaa taaatgatgc tgagaaaact
     7261 gggtagccat atgcagaaaa ccgaaactgg accccttcct tacaccttat acaaaaatta
     7321 actcaagaca gattaaaaac ttaaatgtaa taccccaaac catgaaaacc tgagaagaaa
     7381 acttaggtga taccattcag gacagccgtt ggcaaagact tcatgtaaaa aaatgccaaa
     7441 agcaattgca acaaaagcca aaattgacaa atgggatcta attaaactaa agagcttctg
     7501 cacaacaaaa gaaactatca tcagagtgaa taggtaacct agagaatgcc
//