From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rattus norvegicus PIT-1-alpha (PIT-1) mRNA, complete cds.
Date: 11 Sep 92 10:07:03 GMT
Distribution: bionet
Checksum: 11811     5

LOCUS       RATPIT1A     2327 bp ss-mRNA            ROD       11-SEP-1992
DEFINITION  Rattus norvegicus PIT-1-alpha (PIT-1) mRNA, complete cds.
ACCESSION   L01506
KEYWORDS    DNA dependant dimerization; POU-homeodomain protein;
            nuclear protein; pituitary specific; splice variant;
            transcriptional activator.
SOURCE      Rattus norvegicus (strain Sprague-Dawley) female pituitary cDNA to
            mRNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Konzak,K.E. and Moore,D.D.
  TITLE     Functional isoforms of PIT-1 generated by alternative messenger RNA
            splicing
  JOURNAL   Mol. Endocrinol. 6, 241-247 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             85..960
                     /product="PIT-1-alpha"
                     /gene="PIT-1"
                     /codon_start=1
                     /translation="MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNV
                     MSTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDP
                     TASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAV
                     HGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRR
                     TTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSL
                     NQSLFSISKEHLECR"
     CDS             163..960
                     /note="alternate start"
                     /product="PIT-1-alpha"
                     /gene="PIT-1"
                     /codon_start=1
                     /translation="MHHSAAEGLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVM
                     AGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPE
                     IRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKL
                     KAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEHSKPSSQEI
                     MRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR"
BASE COUNT      698 a    480 c    487 g    662 t
ORIGIN
        1 gccgtgaatc ggccctttga tacagtaata taataaaagc ggactggcaa gcggtgcgtc
       61 ttagttctct actctcttgt gggaatgagt tgccaacctt tcacctcggc tgataccttt
      121 atacctctga attctgacgc ttctgctgcc ctgcctctga gaatgcacca cagtgccgct
      181 gagggtctcc cagcctccaa ccacgccacc aacgtgatgt ccacagcgac aggacttcat
      241 tattctgtgc cttcctgtca ttatggaaac cagccatcca cctacggagt gatggcaggc
      301 actttaaccc cttgtcttta caagtttcca gaccacaccc tgagtcatgg gtttcctccc
      361 ctgcaccaac ctctgctggc ggaggaccca acagcctctg aatttaagca ggaactcagg
      421 cggaaaagta aattggtgga agagccaata gacatggact ccccggaaat ccgagaactg
      481 gagcagtttg ccaacgaatt taaagtgaga agaattaagt taggatacac ccagacaaac
      541 gtgggcgaag ctctggccgc tgtccacggc tccgaattca gtcaaacaac catctgccga
      601 tttgaaaact tgcagctcag tttcaaaaat gcttgcaaac tgaaagcaat tttatccaag
      661 tggctggagg aagctgagca ggtcggagct ttgtacaatg aaaaagtggg agcaaacgaa
      721 aggaagagga aacggaggac aactatcagt atcgccgcta aggatgcttt ggagagacac
      781 tttggagagc acagcaaacc ttcttcgcag gagatcatgc ggatggctga agaattgaat
      841 ctcgagaaag aagtagtaag agtgtggttt tgcaaccgaa ggcagagaga aaaacgggtg
      901 aaaacgagtc tcaatcaaag tctgttctct atttcaaagg agcatcttga gtgcagataa
      961 gacttgcctg tggtagccat gtgtggtagc ctttccattc ctttctgatt tcaagaaaaa
     1021 tcagaagtta cttagcttca taaactagat taaatcagca acccctgcag tttttgtttc
     1081 actttcttct ttctttccct tttagatcca atgatttaaa acaagacgtt ttatttagtt
     1141 gttctcagaa ttcatagcat tgcctttact cctaaatcat caccaagaat gctcacaata
     1201 cctcttccaa ttctgccttt atacctaata cacagagagg tggggataac tgggagagag
     1261 gccatcatat atgtgaatat tttgagttta aaattacctt ttgtaagtca atttattgtt
     1321 ctttaaattt taatcagtaa ggacaaatat ttaccgacta ttaaccaggg atggctcaag
     1381 gttgataatc tattgacttg gccagagaga tgtctcagtg gttaagagca tctgttgctc
     1441 ttccagagga tgtgggttcc atcacctata cagctcacaa ctgtctgtca cactatttcc
     1501 agaggaaatc caaggagtct cctgggttcc attgacactc ggcctgaaaa tgagcacaga
     1561 catacatgta gacaaaatac tcatacatat acagtaaaaa taataaatct ataaacaaaa
     1621 agaaaatata ttggtttata ctcagtatgc ccctagcact atgttttgtt ttgttttgtt
     1681 ttggagtaag gtttgacaat ccagaggtga ctagagacaa ctaagaattt tattaattgc
     1741 cttcagaaat aatcttcagt cagaatctat tgatatcttt gacattaaca cttaggacac
     1801 gttttttgaa caatttgtag gagcatttag gcatgacatc tgggcgtatt cttttataca
     1861 cattagcttt ctgaggctct gctacagaaa acatgtgagc tgcaagctaa acttgctgac
     1921 ccaaataatc cttcagtttt ggctttgttt tgttttgttt ggtagtgagt tcaatcctga
     1981 gcacaagtga aatttaaaaa tgaaaaatat ggtttaggga tccctaacct atatcataaa
     2041 tctgtgtgga agctgcacta gggcgaggct acgtggctta cttgctgtta tgtttccagt
     2101 gactgaaaaa gcactggctc ctagtaggta tgtatagacc atgctaaaag gaatgggccc
     2161 aatggtgaac aaccgctaca aatatgaagg gtaccaggca acctgaaaaa tctaacttgt
     2221 ttttgaagtc tcattgtaga aactcactga ggttccttaa caaagtgtca attttggtct
     2281 cactggtcac attttgattt attaataaaa attggaaata tgaaaaa
//