From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human high mobility group box mRNA, complete cds.
Date: 10 Apr 92 10:06:14 GMT
Distribution: bionet
Checksum: 39636     6

LOCUS       HUMHMGBP     2839 bp ss-mRNA            PRI       10-APR-1992
DEFINITION  Human high mobility group box mRNA, complete cds.
ACCESSION   M86737
KEYWORDS    high mobility group box protein.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2839)
  AUTHORS   Bruhn,S.L., Pil,P.M., Essigmann,J.M., Housman,D.E. and Lippard,S.J.
  TITLE     Isolation and characterization of human cDNA clones encoding a high
            mobility group box protein that recognizes structural distortions
            to DNA caused by binding of the anticancer agent cisplatin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 2307-2311 (1992)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     CDS             275..2404
                     /note="recognizes structural distortions to DNA caused by
                     binding of the anticancer agent cisplatin"
                     /product="high mobility group box"
                     /gene="high mobility group box"
                     /codon_start=1
                     /translation="MAETLEFNDVYQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQ
                     AGELTEGIWRRVALGHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDL
                     CVKGWNWGTVKFGGQLLSFDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSL
                     MEVRFYVPPTQEDGVDPVEAFAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRI
                     YPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILL
                     FSKDEDISLTLNMNEEEVEKRFEGRLTKNMSGSLYEMVSRVMKALVNRKITVPGNFQG
                     HSGAQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEISFVNFARGTTTTRSFDFE
                     IETKQGTQYTFSSIEREEYGKLFDFVNAKKLNIKNRGLKEGMNPSYDEYADSDEDQHD
                     AYLERMKEEGKIREENANDSSDDSGEETDESFNPGEEEEDVAEEFDSNASASSSSNEG
                     DSDRDEKKRKQLKKAKMAKDRKSRKKPVEVKKGKDPNAPKRPMSAYMLWLNASREKIK
                     SDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARRDYEKAMKEYEGGRGESSKR
                     DKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESFKSKEFVSSDESSSGENKSKKKR
                     RRSEDSEEEELASTPPSSEDSASGSDE"
     polyA_signal    2800..2805
                     /gene="high mobility group box"
BASE COUNT      746 a    717 c    786 g    590 t
ORIGIN
        1 gaattccgta cggcttccgg tggcgggacg cggggccgcg cacgcgggaa aagcttcccc
       61 ggtgtccccc catccccctc cccgcgcccc ccccgcgtcc ccccagcgcg cccacctctc
      121 gcgccggggc cctcgcgagg ccgcagcctg aggagattcc caacctgctg agcatccgca
      181 cacccactca ggagttgggg cccagctccc agtttacttg gtttcccttg tgcagcctgg
      241 ggctctgccc aggccaccac aggcaggggt cgacatggca gagacactgg agttcaacga
      301 cgtctatcag gaggtgaaag gttccatgaa tgatggtcga ctgaggttga gccgtcaggg
      361 catcatcttc aagaatagca agacaggcaa agtggacaac atccaggctg gggagttaac
      421 agaaggtatc tggcgccgtg ttgctctggg ccatggactt aaactgctta caaagaatgg
      481 ccatgtctac aagtatgatg gcttccgaga atcggagttt gagaaactct ctgatttctt
      541 caaaactcac tatcgccttg agctaatgga gaaggacctt tgtgtgaagg gctggaactg
      601 ggggacagtg aaatttggtg ggcagctgct ttcctttgac attggtgacc agccagtctt
      661 tgagataccc ctcagcaatg tgtcccagtg caccacaggc aagaatgagg tgacactgga
      721 attccaccaa aacgatgacg cagaggtgtc tctcatggag gtgcgcttct acgtcccacc
      781 cacccaggag gatggtgtgg accctgttga ggcctttgcc cagaatgtgt tgtcaaaggc
      841 ggatgtaatc caggccacgg gagatgccat ctgcatcttc cgggagctgc agtgtctgac
      901 tcctcgtggt cgttatgaca ttcggatcta ccccaccttt ctgcacctgc atggcaagac
      961 ctttgactac aagatcccct acaccacagt actgcgtctg tttttgttac cccacaagga
     1021 ccagcgccag atgttctttg tgatcagcct ggatccccca atcaagcaag gccaaactcg
     1081 ctaccacttc ctgatcctcc tcttctccaa ggacgaggac atttcgttga ctctgaacat
     1141 gaacgaggaa gaagtggaga agcgctttga gggtcggctc accaagaaca tgtcaggatc
     1201 cctctatgag atggtcagcc gggtcatgaa agcactggta aaccgcaaga tcacagtgcc
     1261 aggcaacttc caagggcact caggggccca gtgcattacc tgttcctaca aggcaagctc
     1321 aggactgctc tacccgctgg agcggggctt catctacgtc cacaagccac ctgtgcacat
     1381 ccgcttcgat gagatctcct ttgtcaactt tgctcgtggt accactacta ctcgttcctt
     1441 tgactttgaa attgagacca agcagggcac tcagtatacc ttcagcagca ttgagaggga
     1501 ggagtacggg aaactgtttg attttgtcaa cgcgaaaaag ctcaacatca aaaaccgagg
     1561 attgaaagag ggcatgaacc caagctacga tgaatatgct gactctgatg aggaccagca
     1621 tgatgcctac ttggagagga tgaaggagga aggcaagatc cgggaggaga atgccaatga
     1681 cagcagcgat gactcaggag aagaaaccga tgagtcattc aacccaggtg aagaggagga
     1741 agatgtggca gaggagtttg acagcaacgc ctctgccagc tcctccagta atgagggtga
     1801 cagtgaccgg gatgagaaga agcggaaaca gctcaaaaag gccaagatgg ccaaggaccg
     1861 caagagccgc aagaagcctg tggaggtgaa gaagggcaaa gaccccaatg cccccaagag
     1921 gcccatgtct gcatacatgc tgtggctcaa tgccagccga gagaagatca agtcagacca
     1981 tcctggcatc agcatcacgg atctttccaa gaaggcaggc gagatctgga agggaatgtc
     2041 caaagagaag aaagaggagt gggatcgcaa ggctgaggat gccaggaggg actatgaaaa
     2101 agccatgaaa gaatatgaag ggggccgagg cgagtcttct aagagggaca agtcaaagaa
     2161 gaagaagaaa gtaaaggtaa agatggaaaa gaaatccacg ccctctaggg gctcatcatc
     2221 caagtcgtcc tcaaggcagc taagcgagag cttcaagagc aaagagtttg tgtctagtga
     2281 tgagagctct tcgggagaga acaagagcaa aaagaagagg aggaggagcg aggactctga
     2341 agaagaagaa ctagccagta ctccccccag ctcagaggac tcagcgtcag gatccgatga
     2401 gtagaaacgg aggaaggttc tctttgcgct tgccttctca caccccccga ctccccaccc
     2461 atattttggt accagtttct cctcatgaaa tgcagtccct ggattctgtg ccatctgaac
     2521 atgctctcct gttggtgtgt atgtcactag ggcagtgggg agacgtctta actctgctgc
     2581 ttcccaagga tggctgttta taatttgggg agagataggg tgggaggcag ggcaatgcag
     2641 gatccaaatc ctcatcttac tttcccgacc ttaaggatgt agctgctgct tgtcctgttc
     2701 aagttgctgg agcaggggtc atgtgaggcc aggcctgtag ctcctacctg gggcctattt
     2761 ctactttcat tttgtatttc tggtctgtga aaatgattta ataaagggaa ctgactttgg
     2821 aaaccaaaaa aaggaattc
//