From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens IG VH gene (clone MLH4-1)
Date: 14 Aug 92 10:00:51 GMT
Distribution: bionet
Checksum: 35468     4

LOCUS       HUMVHMLH41    383 bp ss-RNA             PRI       14-AUG-1992
DEFINITION  H.sapiens IG VH gene (clone MLH4-1)
ACCESSION   X54447
KEYWORDS    Ig heavy chain; VH gene family IV; germline VH IV(V2-1);
            variable region.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 383)
  AUTHORS   Harindranath,N.
  JOURNAL   Unpublished (1990)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 383)
  AUTHORS   Harindranath,N., Goldfarb,I.S., Ikematsu,H., Burastero,S.E.,
            Wilder,R.L., Notkins,A.L. and Casali,P.
  TITLE     Complete sequence of the genes encoding the VH and VL regions of
            low-high affinity monoclonal IgM and IgA1 rheumatoid factors
            produced by CD5+ B cells from a rheumatoid arthritis patient
  JOURNAL   Int. Immunol. 3, 865-875 (1991)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 383)
  AUTHORS   Harindranath,N., Goldfarb,I.S., Ikematsu,H., Burastero,S.E.,
            Wilder,R.L., Notkins,A.L. and Casali,P.
  TITLE     Complete sequence of the genes encoding the VH and VL regions of
            low and high affinity monoclonal IgM and IgA1 rheumatoid factors
            produced by CD5+B cells from a rheumatoid arthritis patient
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   4  (bases 1 to 383)
  AUTHORS   Dean,C.R. and Poole,K.
  TITLE     Cloning and nucleotide sequence determination of the ferric
            enterobactin receptor gene of Pseudomonas aeruginosa PAO
  JOURNAL   Unpublished (1993)
  STANDARD  full staff_review
COMMENT     *source: stage=adult; *source: cell_type=granulocyte; *source:
            cell_line=genomic DNA; *source: clone_library=pUC18; *source:
            clone=MLH4-1; *source: isolate=rheumatoid arthritis patient (ML);
            *source: chromosome=14q32; *source: is_germline=Y;
            See also X54435-X54438 & X54441-47
            From EMBL    entry HSVHMLH41;  dated 13-MAR-1992.
FEATURES             Location/Qualifiers
     CDS             83..>383
                     /product="IG heavy chain precursor"
                     /codon_start=3
                     /translation="VLSQLQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQ
                     PPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYY"
     sig_peptide     83..94
                     /codon_start=3
                     /partial
     mat_peptide     95..>383
                     /product="IG heavy chain (V-region)"
                     /codon_start=3
BASE COUNT       77 a    104 c    113 g     89 t
ORIGIN
        1 gtgaatgttt ctaggatgca gacatggaga tatgggaggt gcctctgatc ccagggctca
       61 ctgtgggttt ttctgttcac aggggtcctg tcccagctgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgca ctgtctctgg tggctccatc
      181 agcagtagta gttactactg gggctggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggagta tctattatag tgggagcacc tactacaacc cgtccctcaa gagtcgagtc
      301 accatatccg tagacacgtc caagaaccag ttctccctga agctgagctc tgtgaccgcc
      361 gcagacacgg ctgtgtatta ctg
//