From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Cowpox virus white-pock variant (CPV-W2) (crmA) gene, complete cds.
Date: 26 Jan 93 05:47:01 GMT
Distribution: bionet
Checksum: 03484 5

LOCUS       CPVWPV       1468 bp ds-DNA             VRL       25-JAN-1993
DEFINITION  Cowpox virus white-pock variant (CPV-W2) (crmA) gene, complete cds.
ACCESSION   M14217
KEYWORDS    .
SOURCE      Cowpox virus (strain W2), DNA.
  ORGANISM  Cowpox virus
            Viridae; ds-DNA enveloped viruses; Poxviridae; Chordopoxvirinae.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Pickup,D.J., Ink,B.S., Hu,W., Ray,C.A. and Joklik,W.K.
  TITLE     Hemorrhage in lesions caused by cowpox virus is induced by a viral
            protein that is related to plasma protein inhibitors of serine
            proteases
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83, 7698-7702 (1986)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1468)
  AUTHORS   Ink,B.S. and Pickup,D.J.
  TITLE     Transcription of a oxvirus early gene is regulated both by a short
            promoter element and by a transcriptional termination signal
            controlling transcriptional interference
  JOURNAL   J. Virol. 63, 4632-4644 (1989)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 1468)
  AUTHORS   Palumbo,G.J., Pickup,D.J., Fredrickson,T.N., McIntyre,L.J. and
            Buller,R.M.
  TITLE     Inhibition of an inflammatory response is mediated by a 38 kDa
            protein of cowpox virus
  JOURNAL   Virology 172, 262-273 (1989)
  STANDARD  full automatic
REFERENCE   4  (bases 1 to 1468)
  AUTHORS   Ray,C.A., Black,R.A., Kronheim,S.R., Greenstreet,T.A., Sleath,P.R.,
            Salvesen,G.S. and Pickup,D.J.
  TITLE     Viral inhibition of inflammation: cowpox virus encodes an inhibitor
            of the Interleukin-1b converting enzyme
  JOURNAL   Cell 69, 597-604 (1992)
  STANDARD  full automatic
REFERENCE   5  (bases 1 to 1468)
  AUTHORS   Palumbo,G.J., Glasgow,W.C. and Buller,R.M.
  TITLE     Poxvirus indicud alteration of arachidonate metabolism
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (1993) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             295..1320
                     /gene="crmA"
                     /citation=[3]
                     /citation=[4]
                     /citation=[1]
                     /product="early protein"
                     /codon_start=1
                     /translation="MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSK
                     YVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQTVDFTDCRTVDAINKC
                     VDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVD
                     VSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTN
                     FKKWCDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMCNSDVSVD
                     AMIHKTYIDVNEEYTEAAAATCALVADCASTVTNEFCADHPFIYVIRHVDGKILFVGR
                     YCSPTTN"
BASE COUNT      493 a    231 c    287 g    457 t
ORIGIN      
        1 tccatggaag aacgaaagta gtataaaagt aataaaacaa aaaaaagaat ataaaaaatt
       61 tatagccact ttctttgagg actgttttcc tgaaggaaat gaacctctgg aattagttag
      121 atatatagaa ttagtataca cgctagatta ttctcaaact cctaattatg acagactacg
      181 tagactgttt atacaagatt gaaaatatat ttctttttat tgagtggtgg tagttacgga
      241 tatctaatat taatattaga ctatctctat cgtcacacaa caaaatcgat tgccatggat
      301 atcttcaggg aaatcgcatc ttctatgaaa ggagagaatg tattcatttc tccaccgtca
      361 atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc tgaacagcta
      421 tcaaaatatg tagaaaagga ggcggacaag aataaggatg atatctcatt caagtccatg
      481 aataaagtat atgggcgata ttctgcagtg tttaaagatt cctttttgag aaaaattgga
      541 gataatttcc aaactgttga cttcactgat tgtcgcactg tagatgcgat caacaagtgt
      601 gttgatatct tcactgaggg gaaaattaat ccactattgg atgaaccatt gtctccagat
      661 acctgtctcc tagcaattag tgccgtatac tttaaagcaa aatggttgat gccatttgaa
      721 aaggaattta ccagtgatta tcccttttac gtatctccaa cggaaatggt agatgtaagt
      781 atgatgtcta tgtacggcga ggcatttaat cacgcatctg taaaagaatc attcggcaac
      841 ttttcaatca tagaactgcc atatgttgga gatactagta tggtggtaat tcttccagac
      901 aatattgatg gactagaatc catagaacaa aatctaacag atacaaattt taagaaatgg
      961 tgtgactcta tggatgctat gtttatcgat gtgcacattc ccaagtttaa ggtaacaggc
     1021 tcgtataatc tggtggatgc gctagtaaag ttgggactga cagaggtgtt cggttcaact
     1081 ggagattata gcaatatgtg taattcagat gtgagtgtcg acgctatgat ccacaaaacg
     1141 tatatagatg tcaatgaaga gtatacagaa gcagctgcag caacttgtgc gctggtggca
     1201 gactgtgcat caacagttac aaatgagttc tgtgcagatc atccgttcat ctatgtgatt
     1261 aggcatgtcg atggcaaaat tcttttcgtt ggtagatatt gctctccaac aactaattaa
     1321 atcacattct taatattaga atattagaat attatatagt taagattttt actaattggt
     1381 taaccatttt tttaaaaaaa tagaaaaaaa acatgttata ttagcgaggg tcgttattct
     1441 tccaattgca attggtaaga tgacggcc
//