From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mast cell carboxypeptidase A (MC-CPA) gene, exons 4-10.
Date: 25 Jul 92 10:03:43 GMT
Distribution: bionet
Checksum: 51436    10

LOCUS       HUMMCCPA03   6192 bp ds-DNA             PRI       25-JUL-1992
DEFINITION  Human mast cell carboxypeptidase A (MC-CPA) gene, exons 4-10.
ACCESSION   M73718
KEYWORDS    carboxypeptidase; metalloexopeptidase; secretory granules.
SEGMENT     3 of 5
SOURCE      Homo sapiens (library: lambda-gHMCCPA-3) DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 6192)
  AUTHORS   Reynolds,D.S., Gurley,D.S. and Austen,K.F.
  TITLE     Cloning and characterization of the novel gene for mast cell
            carboxypeptidase A
  JOURNAL   J. Clin. Invest. 89, 273-282 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     intron          order(M73717:477..912,1..582)
                     /number=3
                     /gene="MC-CPA"
     exon            583..685
                     /number=4
                     /gene="CPA3"
     intron          686..788
                     /number=4
                     /gene="MC-CPA"
     exon            789..890
                     /number=5
                     /gene="MC-CPA"
     intron          891..1929
                     /number=5
                     /gene="MC-CPA"
     exon            1930..2031
                     /number=6
                     /gene="MC-CPA"
     intron          2032..3662
                     /number=6
                     /gene="MC-CPA"
     exon            3663..3773
                     /number=7
                     /gene="MC-CPA"
     intron          3774..4645
                     /number=7
                     /gene="MC-CPA"
     exon            4646..4736
                     /number=8
                     /gene="MC-CPA"
     intron          4737..5753
                     /number=8
                     /gene="MC-CPA"
     exon            5754..5956
                     /number=9
                     /gene="MC-CPA"
BASE COUNT     2085 a   1124 c   1053 g   1930 t
ORIGIN
        1 atctgtagat gtgtgcatga aagaatccct tgttgcctgt gtttatgtgg atgtagatgt
       61 gtgtgtgttt tggagaagga tggggagtac tatagcagta caatacgagc cacatgcata
      121 attttaaaat tgtggtaacc acattaaaaa agtaaaaagc aacaggtaaa attaactgta
      181 gcaatacatt ttatttagcc caatatatct gaaattttta ttctacacaa cataaaactt
      241 attagtgaga tagtttatat catttttata ctatcttcaa aatctggtgt atattttaca
      301 catacagcaa tctactcttg gacaagcccc acttcacatg tcctgtatgc acttggggct
      361 agagactatc acactggaca gcacagctct agataaatgg ggagatcaga agccagacac
      421 atgatatgtc taaaggagat agctagagga agaataatga agaaacagag caaacttgat
      481 taaagataaa ggagaaggaa gagaaatttc tgcaaatgaa agataactgt gttttccttt
      541 ctcatgataa aacatgtatt ttatcattcc cctgtcaaac agaatcttga ttcatgatct
      601 acaagaagag attgagaaac agtttgatgt taaagaagat atcccaggca ggcacagcta
      661 cgcaaaatac aataattggg aaaaggtaca gtaaaaaatg cctgtacttt tttttaagtt
      721 acccttaata tttattgtca ttttgttttc ttttattcta atttctcaaa attgattttg
      781 ctcttaagat tgtggcttgg actgaaaaga tgatggataa gtatcctgaa atggtctctc
      841 gtattaaaat tggatctact gttgaagata atccactata tgttctgaag gtaaaaataa
      901 ctcaagaacc actaattctt attactgttg aaaaacatga atttaaaagt tactttgtaa
      961 cacaactaag ctaattctga gctaatacat attatctctg aaagaatatt taagctctag
     1021 acatccatta aagaatagaa atgacaagcg gttttggtgg aaccaagaaa gtgtctggat
     1081 aaacatttgt cagagattgc acagtggaca aacccaaaca aatatttcat cccacagctt
     1141 tattacaaga gtccatgatg tctctggtat aaaaaaaccc tcatccctta aaatgcagtg
     1201 aaactgatga atgaatgtca tgaagggaat ttaaatatca tagcatcata ggactgtaga
     1261 acagtgtgtt aggcatttca accatggatt gcttgagggt tccctatatc agagccaaca
     1321 atttccactc cattgctgct ggatttttgc acatccaaag atactgctcc ctgaagcagc
     1381 cacttaacaa gtgagaagcc catccacatc ccaaaccccc attcattcat tatctccaac
     1441 cactcaaaac aaacctgcac tctcttcaaa atgacagcca ttcaagtatc cagtactatt
     1501 tcccttcccc actccaacac aacacaagat cttctccatt ccagggtaaa tatccccagt
     1561 ttacacaacc agaaaaacaa aaggaagtgg cagaaacaaa agtgacttta taataaattt
     1621 ctcagaacac aggatgttag taataaaata aaaacaatgg actacaaatt tttttcaaaa
     1681 tcctaccagc tgccctgaca ctagaaaaat tttttgaaaa atatgcattg taatagatta
     1741 tgaattatgt atagacattt aaggatatgt cccatggtcc cttctgagaa caatatgtgc
     1801 atacatggtt ctcattcaac aatagacagg gggaaataat tgctttgaga atatgaatga
     1861 gttattggtc aacaagggat caatgtgtga gtttgttcaa aacaatatct caagtttact
     1921 tttaaataga ttggggaaaa gaatgaaaga agaaaggcta tttttatgga ttgtggcatt
     1981 cacgcacgag aatgggtctc cccagcattc tgccagtggt ttgtctatca ggtaagtgaa
     2041 tcagaagact cccaattctc ctttgactgc caagtctcca gcacttcact aagtggcgac
     2101 atctttccaa acacgcaatt ccacttagct agaagagccc atacttggtg ctgtcaggga
     2161 agaaacgctc tgaattttac tcatcattac agtttttatg aaattgacaa cttccctcca
     2221 aacaattctt aaactcaagc taagagttta tgaaactcac acttttcttg ggctatcaca
     2281 tgaaagtttt tactgtagtc aagtatggaa aatctgaaac aaccttcaca taacctacaa
     2341 atgtaacttt tcttcaatga gctcaaaaca tagatattta attttaattc ctctttagat
     2401 aatacattgg ccgcacatgt acttggaatt ttaatattta agtttccttt ctgagtgaaa
     2461 aataactcac ttttttcttt tttttttttt gagatggagt ctcactctgt cacccaggct
     2521 ggaatgcagt ggtgcaatct cgtctcactg caacctccgc ctcctgggtt caagcaattc
     2581 tactacctca gtctccaaag tagctggaac tacaggcatg cgccaccatg cctggctaat
     2641 ttttgtattt ttagtagaga ctggattttg ccatgttggc caggctgtta tcaaactcct
     2701 gatcccaagt aatctgtccc cctcggcctc ccaaagtgct gggataacag gtatgagcca
     2761 ccacactggg cctacaattc acttttttaa aaggtttatc tagtttatat attcaatatt
     2821 cctctcactc tattgccaat gtattttgac tcctaccata ttttaatttt ctctttctgt
     2881 cagcttttgc acatggcaca gtggtgaaat atgtgtaaca atggttttct gggcatagat
     2941 atttttctag aaaagaatcc accaggaagt gacctgtagt tacttttgct ctcccaactg
     3001 agggccaaga gctcccccta ctcaacacat aaaggaatgc acatcacagg tctacaaaaa
     3061 atcttgtctc caattcagat gtacctagaa ggacttccca agagtggtga gagagatttt
     3121 aggtagctac agaaagtgca tgtgattaga gaaatttcag tcagatatag aaaaaaaaaa
     3181 gttgttcaat ctctgaattc ttgggtattt tattaataca attttttatt taatcctgct
     3241 tataactatc tcacaaattc tctccaatat tttcatattc ctgtgcttac agactctatc
     3301 tatatttatg taaaagatgt gagagaatca attaaaaata agttgtatta caaattttcc
     3361 atttggcttc caatctttct atgaaacata tctctcatgc tacatttgga atgctataag
     3421 tctcgataat taaatgctcc tttaaagact attcatttcc attaatgtca ctagtctaaa
     3481 taagttaggt ttttttcccc tttaaactat atggattgtt tatttttgtt cattttaggg
     3541 aaaatatgct tgaaaacatg tgaccttggg aagtgactca agttattact attataacca
     3601 cagctttcca cataatagct aaacttcata ccaatagctt aatttttttt cacctccgac
     3661 aggcaaccaa aacttatggg agaaacaaaa ttatgaccaa actcttggac cgaatgaatt
     3721 tttacattct tcctgtgttc aatgttgatg gatatatttg gtcatggaca aaggtactgc
     3781 tctctactct cttgtttgca tttagatatt atttgctggc tttaatacac aatgttatgc
     3841 attcagctta gggtttaggt aactagttaa ttctaattca gaaaagtata ttttttaaaa
     3901 tctcagtttc aaattaagta tgatttcttg gttgcatagg tatccttgaa ataatataaa
     3961 atttttgctg ctgaagctag ttatgtggga aaatgaaata aagtagtaat tacagaggaa
     4021 atgtatgatt gcattatatg atatggcata tctagctaag aataaagcca attaattgat
     4081 tttaaaacaa aaacctttgt atttcatcaa ttttgaatag aatttgaggt agaatcattg
     4141 tatcaaaaaa aataaaagag aggtacagat acctatttgt ctttttacag tatattttat
     4201 tatcctgctt ttgctaaata agaactctca ggcagacact gtcacatcaa attattttct
     4261 gcaaataatg ctccaacagt aaaaatttga cctgcattat atctgaatct atatatggtg
     4321 aacaagctaa tgaagttata atttaaatta tggttaattt cagaacaccg ttagtcatct
     4381 tctaatactg tgaactaatc aacagtgttt aaaattaact gaattatttc atcaaagcct
     4441 aaggatataa tattaaaaac catgattctg aaaatactac aaattataag aaaacaatat
     4501 ttttttcttt ttataataaa gggcctcaag ttaactagat agatttcaaa taaagttgca
     4561 gacacctgca gagagaattt gaaatgatca aattgaaaaa tgcaaactga tcttgtgtaa
     4621 acacttacgt cattcaatct ggcagaaccg catgtggaga aaaaatcgtt ccaagaacca
     4681 aaactccaaa tgcatcggca ctgacctcaa caggaatttt aatgcttcat ggaactgtga
     4741 gtagcagact tgctatcaag gaaaattgct ataaggaata tttaggtccc aaacttaact
     4801 aaaacaccta cttgttcagt aaaaatagtt atgctttgag tgagtgttaa cttttgtatc
     4861 tataacatga aagacaatca tcactaccat tgagggatgt cttgctgtgt ggaaggaaat
     4921 gaggaggaag ggactgttta tcaaaccatc tcttacttac tatatctagt ttgctaaaaa
     4981 ttaagcacaa tccaaatgta taaaaattca gataatctga ataaagacct cagattcctc
     5041 tgcttcctga tgtgagaaat gtcagtggct aaaagcaaca tacagacagt ttttcagata
     5101 tttagtgaaa agagtcatct ggagcaaaga aagtgaaaaa gtttaacaga aatacgatga
     5161 taagcagagg cctgctacat cagacgatgc tttagttgct atacaactat gacttcatca
     5221 ctgcacactt tcaaggagaa attaccattg ccccaattta tatatttctt ctgtgcctaa
     5281 ttttgttgaa aacatcacct gagcttttaa ctgtattcta ccataatgaa catagaagag
     5341 cagcagctat ctctaattga gagctttctg ctgaaaaagg ctgaagaaac ttgtgcccag
     5401 ggaaggtaat tcacaccagc ccccagcgca ttagagctgg ggttgaatta gaactggagt
     5461 gtatctggct ccaagtcatg gctgcttctg atttattact cctgtggcct tgggaaagga
     5521 caaggaagta aacaaggctt agaatattcc agtgggctaa gtctgttaca atctggcatg
     5581 tgtgtgcaat gttaatctgt agtgactatg atacaagaga cattgaagca gccctgtaaa
     5641 catgagaggc aaaaacattt aaaacattct gtgaatctat aatacattag aagaggcagg
     5701 agctatatgg atggggagca gactgtggtc tcatccacct atgtcttctg cagccattcc
     5761 taacaccaat gacccatgtg cagataacta tcggggctct gcaccagagt ccgagaaaga
     5821 gacgaaagct gtcactaatt tcattagaag ccacctgaat gaaatcaagg tttacatcac
     5881 cttccattcc tactcccaga tgctattgtt tccctatgga tatacatcaa aactgccacc
     5941 taaccatgag gacttggtac gtagacaaaa gtttgcactt catgcatcga caataccatt
     6001 gactttcagt ctgttcttca ttaacttggg tatgttgaaa gaatttcaca ttttaatgtc
     6061 aaagaaaaga actaatgaaa tttgccttga agttaaaatc atgatcttta gattgatttt
     6121 tcattgataa aagtatatag ataataaatt cctttaatgt gattctcagg aggaaaaaaa
     6181 aatcaggaag aa
//