From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human myeloperoxidase (MPO) mRNA, complete cds.
Date: 5 Nov 92 23:10:32 GMT
Distribution: bionet
Checksum: 64348 8

LOCUS       HUMMPOR      3213 bp ss-mRNA            PRI       15-JUN-1989
DEFINITION  Human myeloperoxidase (MPO) mRNA, complete cds.
ACCESSION   X04876
KEYWORDS    glycoprotein; myeloperoxidase; unidentified reading frame.
SOURCE      human (Homo sapiens).
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3213)
  AUTHORS   Johnson,K.R., Nauseef,W.M., Care,A., Wheelock,M.J., Shane,S.,
            Hudson,S., Koeffler,H.P., Selsted,M., Miller,C. and Rovera,G.
  TITLE     Characterization of cDNA clones for human myeloperoxidase:
            predicted amino acid sequence and evidence for multiple mRNA
            species
  JOURNAL   Nucleic Acids Res. 15, 2013-2028 (1987)
  STANDARD  full automatic
COMMENT     [1]  enum. 1 to 3213.
               *source: cell line; HL-60 promyelocytic leukemia cells;
              EMBL features not translated to GenBank features:
              key        from     to       description
              SITE        578    586       pot. N-glycosylation site (AA 139-14

              SITE       1130   1138       pot. N-glycosylation site (AA 323-32

              SITE       1226   1234       pot. N-glycosylation site (AA 355-35

              SITE       1334   1342       pot. N-glycosylation site (AA 391-39

              SITE       2348   2356       pot. N-glycosylation site (AA 729-73

              SITE       3172   3177       polyadenylation signal
              SITE       3207   3213       seq. pot. involved in 3' end
            formati.
FEATURES             Location/Qualifiers
     sig_peptide     164..286
                     /gene="MPO"
                     /codon_start=1
     mat_peptide     662..2398
                     /product="myeloperoxidase"
                     /gene="MPO"
                     /codon_start=1
     mat_peptide     662..1000
                     /product="myeloperoxidase light chain"
                     /gene="MPO"
                     /codon_start=1
     mat_peptide     998..2398
                     /product="myeloperoxidase heavy chain"
                     /gene="MPO"
                     /codon_start=1
     CDS             31..66
                     /note="ORF"
                     /codon_start=1
                     /translation="MTAAGKGIREQ"
     CDS             164..2401
                     /EC_number="1.11.1.7"
                     /gene="MPO"
                     /product="myeloperoxidase"
                     /codon_start=1
                     /translation="MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGVLAILATPQ
                     PSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYF
                     KQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAY
                     QDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVK
                     RNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFV
                     TGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALT
                     SFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNR
                     SARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIV
                     GAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPF
                     MFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD
                     EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNL
                     KLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN
                     EGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLAS
                     WREAS"
BASE COUNT      647 a    950 c    934 g    682 t
ORIGIN      
        1 agctgtggag gtggggtcct tggaagctgg atgacagcag ctggcaaggg gataagagag
       61 cagtgagccc ctccctcaag gaggtctggc tttatccata gacagggccc tctgaggtgg
      121 ggctgaggta caaaggggga ttgagcagcc caggagaaga gagatggggg ttcccttctt
      181 ctcttctctc agatgcatgg tggacttagg accttgctgg gctgggggtc tcactgcaga
      241 gatgaagctg cttctggccc tagcaggcgt cctggccatt ctggccacgc cccagccctc
      301 tgaaggtgct gctccagctg tcctggggga ggtggacacc tcgttggtgc tgagctccat
      361 ggaggaggcc aagcagctgg tggacaaggc ctacaaggag cggcgggaaa gcatcaagca
      421 gcggcttcgc agcggctcag ccagccccat ggaactccta tcctacttca agcagccggt
      481 ggcagccacc aggacggcgg tgagggccgc tgactacctg cacgtggctc tagacctgct
      541 ggagaggaag ctgcggtccc tgtggcgaag gccattcaat gtcactgatg tgctgacgcc
      601 cgcccagctg aatgtgttgt ccaagtcaag cggctgcgcc taccaggacg tgggggtgac
      661 ttgcccggag caggacaaat accgcaccat caccgggatg tgcaacaaca gacgcagccc
      721 cacgctgggg gcctccaacc gtgcctttgt gcgctggctg ccggcggagt atgaggacgg
      781 cttctctctt ccctacggct ggacgcccgg ggtcaagcgc aacggcttcc cggtggctct
      841 ggctcgcgcg gtctccaacg agatcgtgcg cttccccact gatcagctga ctccggacca
      901 ggagcgctca ctcatgttca tgcaatgggg ccagctgttg gaccacgacc tcgacttcac
      961 ccctgagccg gccgcccggg cctccttcgt cactggcgtc aactgcgaga ccagctgcgt
     1021 tcagcagccg ccctgcttcc cgctcaagat cccgcccaat gacccccgca tcaagaacca
     1081 agccgactgc atcccgttct tccgctcctg cccggcttgc cccgggagca acatcaccat
     1141 ccgcaaccag atcaacgcgc tcacttcctt cgtggacgcc agcatggtgt acggcagcga
     1201 ggagcccctg gccaggaacc tgcgcaacat gtccaaccag ctggggctgc tggccgtcaa
     1261 ccagcgcttc caagacaacg gccgggccct gctgcccttt gacaacctgc acgatgaccc
     1321 ctgtctcctc accaaccgct cagcgcgcat cccctgcttc ctggcagggg acacccgttc
     1381 cagtgagatg cccgagctca cctccatgca caccctctta cttcgggagc acaaccggct
     1441 ggccacagag ctcaagagcc tgaaccctag gtgggatggg gagaggctct accaggaagc
     1501 ccggaagatc gtgggggcca tggtccagat catcacttac cgggactacc tgcccctggt
     1561 gctggggcca acggccatga ggaagtacct gcccacgtac cgttcctaca atgactcagt
     1621 ggacccacgc atcgccaacg tcttcaccaa tgccttccgc tacggccaca ccctcatcca
     1681 acccttcatg ttccgcctgg acaatcggta ccagcccatg gaacccaacc cccgtgtccc
     1741 cctcagcagg gtcttttttg cctcctggag ggtcgtgctg gaaggtggca ttgaccccat
     1801 cctccggggc ctcatggcca cccctgccaa gctgaatcgt cagaaccaaa ttgcagtgga
     1861 tgagatccgg gagcgattgt ttgagcaggt catgaggatt gggctggacc tgcctgctct
     1921 gaacatgcag cgcagcaggg accacggcct cccaggatac aatgcctgga ggcgcttctg
     1981 tgggctcccg cagcctgaaa ctgtgggcca gctgggcacg gtgctgagga acctgaaatt
     2041 ggcgaggaaa ctgatggagc agtatggcac gcccaacaac atcgacatct ggatgggcgg
     2101 cgtgtccgag cctctgaagc gcaaaggccg cgtgggccca ctcctcgcct gcatcatcgg
     2161 tacccagttc aggaagctcc gggatggtga tcggttttgg tgggagaacg agggtgtgtt
     2221 cagcatgcag cagcgacagg ccctggccca gatctcattg ccccggatca tctgcgacaa
     2281 cacaggcatc accaccgtgt ctaagaacaa catcttcatg tccaactcat atccccggga
     2341 ctttgtcaac tgcagtacac ttcctgcatt gaacctggct tcctggaggg aagcctccta
     2401 gaggccaggt aagggggtgc agcagtgagg ggtatatctg ggctggccag ttggaaccac
     2461 ggagatctcc ttgccctaga tgagcccagc cctgttctgg gtgcagctga gaaaatgagt
     2521 gactagacgt tcatttgtgt gctcatgtat gtgcgaagta tataaattgg cttttcatgc
     2581 gtgtgtgttg tctgaacatg gggagtgttt catgggttat gtgtatgtgc catttatgtg
     2641 agtgtgtgtt tgtgctgatg agaatactga gtatgtggaa ggcagcagag cggactggtg
     2701 aggagcacag ctcaggaact agacgtgcct gggttccaat cctggctctg tggcttgcta
     2761 gctatgtgac cttgagcaaa ttaccctcct taaacaagag ttttcttcct tgtaaattac
     2821 atctgtcatg gtttcttgga gggcccactt gtatcctctg gttcttcatt tattgagcac
     2881 ctactacatg caaggcactg tactaggcgt gagaagcata tagaggcaag aaagagatac
     2941 caagatgcca tctgtgtcct ggttagcaga gctggaccag tggtgccttg gagggataag
     3001 ccagctgcag ctgggctgtg tggttgactt atgggcccag ccagccaggc tcaggccatg
     3061 gctccccttt ttcttcctca ccctgatttc ttgcttattc actgaagttc tcctgaagag
     3121 gaactgggcc tgttgccctt tctgtaccat tagtgctccc atgtttatga taataaaggc
     3181 accgtgatgg ggacctccac tctgtctgtg tct
//