From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human interferon-induced cellular resistance mediator protein (MxA)
Date: 5 Nov 92 23:10:49 GMT
Distribution: bionet
Checksum: 35332 6

LOCUS       HUMMXA       2651 bp ss-mRNA            PRI       15-MAR-1990
DEFINITION  Human interferon-induced cellular resistance mediator protein (MxA)
            mRNA, complete cds.
ACCESSION   M30817
KEYWORDS    interferon-induced cellular resistance mediator protein;
            interferon-induced protein.
SOURCE      Human IFN-alpha-2 treated cell line T98G, cDNA to mRNA, clone MxA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Aebi,M., Faeh,J., Hurt,N., Samuel,C.E., Thomis,D.C., Bazzigher,L.,
            Pavlovic,J., Haller,O. and Staeheli,P.
  TITLE     cDNA structures and regulation of two interferon-induced human Mx
            proteins
  JOURNAL   Mol. Cell. Biol. 9, 5062-5072 (1989)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mRNA            <1..2651
                     /note="MxA mRNA"
     CDS             211..2199
                     /product="interferon-induced Mx protein"
                     /codon_start=1
                     /translation="MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQ
                     YEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIV
                     TRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHE
                     LITREISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVP
                     SNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYM
                     IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITH
                     ICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKINAFNQDITALMQG
                     EETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVN
                     YRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIED
                     IRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQS
                     SSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKD
                     TYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG"
BASE COUNT      732 a    646 c    704 g    569 t
ORIGIN      2 bp upstream of EcoRI site.
        1 ggaattctgt ggccatactg cgaggagatc ggttccgggt cggaggctac aggaagactc
       61 ccactccctg aaatctggag tgaagaacgc cgccatccag ccaccattcc aaggaggtgc
      121 aggagaacag ctctgtgata ccatttaact tgttgacatt acttttattt gaaggaacgt
      181 atattagagc ttactttgca aagaaggaag atggttgttt ccgaagtgga catcgcaaaa
      241 gctgatccag ctgctgcatc ccaccctcta ttactgaatg gagatgctac tgtggcccag
      301 aaaaatccag gctcggtggc cgagaacaac ctgtgcagcc agtatgagga gaaggtgcgc
      361 ccctgcatcg acctcattga ctccctgcgg gctctaggtg tggagcagga cctggccctg
      421 ccagccatcg ccgtcatcgg ggaccagagc tcgggcaaga gctccgtgtt ggaggcactg
      481 tcaggagttg cccttcccag aggcagcggg atcgtgacca gatgcccgct ggtgctgaaa
      541 ctgaagaaac ttgtgaacga agataagtgg agaggcaagg tcagttacca ggactacgag
      601 attgagattt cggatgcttc agaggtagaa aaggaaatta ataaagccca gaatgccatc
      661 gccggggaag gaatgggaat cagtcatgag ctaatcaccc gtgagatcag ctcccgagat
      721 gtcccggatc tgactctaat agaccttcct ggcataacca gagtggctgt gggcaatcag
      781 cctgctgaca ttgggtataa gatcaagaca ctcatcaaga agtacatcca gaggcaggag
      841 acaatcagcc tggtggtggt ccccagtaat gtggacattg ccaccacaga ggctctcagc
      901 atggcccagg aggtggaccc cgagggagac aggaccatcg gaatcttgac gaagcctgat
      961 ctggtggaca aaggaactga agacaaggtt gtggacgtgg tgcggaacct cgtgttccac
     1021 ctgaagaagg gttacatgat tgtcaagtgc cggggccagc aggagatcca ggaccagctg
     1081 agcctgtccg aagccctgca gagagagaag atcttctttg agaaccaccc atatttcagg
     1141 gatctgctgg aggaaggaaa ggccacggtt ccctgcctgg cagaaaaact taccagcgag
     1201 ctcatcacac atatctgtaa atctctgccc ctgttagaaa atcaaatcaa ggagactcac
     1261 cagagaataa cagaggagct acaaaagtat ggtgtcgaca taccggaaga cgaaaatgaa
     1321 aaaatgttct tcctgataga taaaattaat gcctttaatc aggacatcac tgctctcatg
     1381 caaggagagg aaactgtagg ggaggaagac attcggctgt ttaccagact ccgacacgag
     1441 ttccacaaat ggagtacaat aattgaaaac aattttcaag aaggccataa aattttgagt
     1501 agaaaaatcc agaaatttga aaatcagtat cgtggtagag agctgccagg ctttgtgaat
     1561 tacaggacat ttgagacaat cgtgaaacag caaatcaagg cactggaaga gccggctgtg
     1621 gatatgctac acaccgtgac ggatatggtc cggcttgctt tcacagatgt ttcgataaaa
     1681 aattttgaag agttttttaa cctccacaga accgccaagt ccaaaattga agacattaga
     1741 gcagaacaag agagagaagg tgagaagctg atccgcctcc acttccagat ggaacagatt
     1801 gtctactgcc aggaccaggt atacaggggt gcattgcaga aggtcagaga gaaggagctg
     1861 gaagaagaaa agaagaagaa atcctgggat tttggggctt tccaatccag ctcggcaaca
     1921 gactcttcca tggaggagat ctttcagcac ctgatggcct atcaccagga ggccagcaag
     1981 cgcatctcca gccacatccc tttgatcatc cagttcttca tgctccagac gtacggccag
     2041 cagcttcaga aggccatgct gcagctcctg caggacaagg acacctacag ctggctcctg
     2101 aaggagcgga gcgacaccag cgacaagcgg aagttcctga aggagcggct tgcacggctg
     2161 acgcaggctc ggcgccggct tgcccagttc cccggttaac cacactctgt ccagccccgt
     2221 agacgtgcac gcacactgtc tgcccccgtt cccgggtagc cactggactg acgacttgag
     2281 tgctcagtag tcagactgga tagtccgttc ctgcttatcc gttagccgtg gtgatttagc
     2341 aggaagctgt gagagcagtt tggtttctag catgaagaca gagccccacc ctcagatgca
     2401 catgagctgg cgggattgaa ggatgctgtc ttcgtactgg gaaagggatt ttcagccctc
     2461 agaatcgctc caccttgcag ctctcccctt ctctgtattc ctagaaactg acacatgctg
     2521 aacatcacag cttatttcct catttttata atgtcccttc acaaacccag tgttttagga
     2581 gcatgagtgc cgtgtgtgtg cgtcctgtcg gagccctgtc tctctctctg taataaactc
     2641 atttctagca g
//