From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human lamin B2 gene and ppv1 gene.
Date: 30 Jul 92 10:01:17 GMT
Distribution: bionet
Checksum: 40424    12

LOCUS       HUMLAMB2B    6953 bp ds-DNA             PRI       30-JUL-1992
DEFINITION  Human lamin B2 gene and ppv1 gene.
ACCESSION   M94363
KEYWORDS    lamin B2.
SOURCE      chromosome 19
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 6953)
  AUTHORS   Biamonti,G., Giacca,M., Perini,G., Contreas,G., Zentilin,L.,
            Weighardt,F., Guerra,M., Valle,G.D., Saccone,S., Riva,S. and
            Falaschi,A.
  TITLE     The gene for a novel human lamin maps at a highly transcribed locus
            of chromosome 19 which replicates at the onset of S-phase
  JOURNAL   Mol. Cell. Biol. 12, 3499-3506 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     rep_origin      1..6953
                     /note="this region contains a genomic replication origin
                     associated with the lamin b2 gene and the ppv1 gene"
                     /gene="lamin B2"
                     /evidence=EXPERIMENTAL
     misc_feature    1..1248
                     /note="putative cds"
                     /product="lamin"
                     /gene="lamin B2"
     intron          1..264
                     /gene="lamin B2"
     exon            265..349
                     /number=-3
                     /gene="lamin B2"
     intron          350..507
                     /gene="lamin B2"
     exon            508..618
                     /number=-2
                     /gene="lamin B2"
     intron          619..1206
                     /gene="lamin B2"
     exon            1207..3982
                     /note="last"
                     /gene="lamin B2"
     3'UTR           1249..3982
                     /gene="lamin B2"
     polyA_signal    3965..3970
                     /gene="lamin B2"
     protein_bind    4187..4203
                     /bound_moiety="'USF-MLTF'"
                     /evidence=EXPERIMENTAL
     exon            4577..4734
                     /number=1
                     /gene="ppv1"
     intron          4735..4822
                     /number=1
                     /gene="ppv1"
     exon            4823..4891
                     /number=2
                     /gene="ppv1"
     intron          4892..5101
                     /number=2
                     /gene="ppv1"
     exon            5102..5544
                     /number=3
                     /note="last"
                     /gene="ppv1"
     polyA_signal    5554..5559
                     /gene="ppv1"
BASE COUNT     1261 a   2076 c   2212 g   1404 t
ORIGIN
        1 gttaacagtc aggcgcatgg gccatggagc ctcctgggtg tcagatccca gttcagcccc
       61 tgcttgccaa gagcccttgg cctctgtgaa ccctggtctc ttcttgtgta tcctggggac
      121 catcaccctg gataagcctg cgtcgggctg gaaggactga acgcccaggg cattgaaggg
      181 gctttgtggt aggggccact ggctggccca cgtccctgga accagaggtg accctgatgg
      241 ggccattgtt attggggtcc tcaggtgtgg gcagctggtg acgggggtgg cccacagccc
      301 cccctcgacg ctggtgtgga agggccagag cagctggggc acgggcgaga cttccgcacc
      361 gtcctggtta acgcggatgg cgaggtgggt gtgtgtggct tggggggtgc tcggctggag
      421 tcctgggcag ggtctgggca ccctcggggc cgccacagca gctctgggcc gatcccggga
      481 catgccgccg tgtcctgtcc cgcacaggaa gtggccatga ggactgtgaa gaagtcctcg
      541 gtgatgcgtg agaatgagaa tggggaggaa gaggaggagg aagccgagtt tggcgaggag
      601 gatcttttcc accaacaggt aggacccctg tgcccacttg cggctggggg gcagcctctg
      661 gggcagagtg agctcgtgca cacacataca catgcgtgct ggccgcatcc ccgacgggag
      721 ctccatctgg ctgccgtggc tcagggtgaa gccagccttg ctgttaccag cacggcagag
      781 acctgttctt tcctcctggg tcgtgcccat cgtgtgaatt tgcgacatca cagacctcag
      841 ggtagctggc cagggggatc cctgagaggt gggtgttgaa cagctcccaa atgctctctc
      901 ctcaaccggc ttcctcagtc gaagaagcag ccagtcctct actgctctgg gagaagatga
      961 gtcagaaacc acagctgcat taaacgcgtg cgtcgcaagt tcctgtgact gttttggaac
     1021 ccagaacaga atgtgtagct cacaggcggg ctcatgggga catggaagtg gaatggaagg
     1081 ctctagaaat agacactgtt gttgctcagc ccctccctgg tggggaggtg ggggcagcca
     1141 tctacctgcc ggctgcctcc aggctggccc tcatcatggc cgaccttcct tccttccttc
     1201 ctgaaggggg acccgaggac cacctcaaga ggctgctacg tgatgtgaac ccacactcct
     1261 catccacaca cctttcttta cccagagcca ctgaaaacta ttttttatca ttggctttct
     1321 ttagttcttg atacatttct agagaatttc taagcgaact gccagaacgt gtgggtgggt
     1381 ctcccccagc cctccctcct ggcgggtctc ctccagcctc acttcgctgc cacttcgccg
     1441 ctgccccgga gacttttcaa tcccacccca ctcctcatct caccatttgg tcaaattgga
     1501 agcccagggc caggacccgg aggtttagaa gatgcttggg cttggaggga ggagggccgg
     1561 cgaggctagc gaggggacag gagacggccc tgctgcggac ggagcgcgga aactgcgtag
     1621 gaattcagtg gtggtgggtt tttttaaggc tttctacaaa accaaattca gaatccaggc
     1681 gtcgacctgg tggggcccgg ggcaagcctg cattctggct gcccagcttc ggacagcggg
     1741 aactcctcag gcagccacgc agcgggtgtg ggccagcatg gggatggcgt ggccccaggg
     1801 gggttttcac tccgctgcct gggcttccag attcccgttc tggcagcgac cggccgggtt
     1861 tctcggaccg ttgactttat ttgggggagt tttcccgcag ttcagttcct gactgtgcaa
     1921 ggccaacagg gcaggggagg ggaagacctg gggaaggaag aatgaggaca cagtcccgtc
     1981 gtaagacctg tcacaacaat aagcagggag gggagatgtg gaggggacac atctggttgc
     2041 cttggaggca gaagctgtga gtttcagaac agctgtctgc agggaacgcc accatgttga
     2101 ccctctggag gagagcgctg tggagcccct cccgtgttcc agctccgtct gccctgtgcc
     2161 tatatatcac atgcgtctat catactgtgt ctttatctgt gatttttctc gctgaaacat
     2221 gtttctcaga cagccaaggc cacctgactc ctatcacgac gcacccaagc ccctcagtcc
     2281 agcttcccaa tgcctggcac ccccttcggc aatagctcac cgtttacacc ctccctcata
     2341 gatacacaga agttattttt ttaatggata tttatttttt tacattggtc agtacacagg
     2401 tcagggagct cacgccaggg ccttgaggac aggctgaccc tcctccccgg ggtggcgtgg
     2461 ggctggggca cccccgacgg cagagcctcc ttcagaaagt gcagctcaag tcttaaagac
     2521 accaaaactg agccatgggc acgcgccgtc tccgggccat ggcgttcact gcagggcggg
     2581 ggcggcaccg ctcccctgtg actgcatccc gcctccctgg ggacctgcct gtggcaggaa
     2641 ggaatggggg gccccagccc aggccgggaa ggagccagcg gccgacaaag cagaaacacc
     2701 gctgctccac gtagcccctg ctggctgtcc ttgctctcag aagtcccggt cccatgtaga
     2761 tagagcccgg cggatcttac caaagcattt cctcctggag gctacgccgc ttggtgctcc
     2821 cagtgaggcg gctggtaggg agctttgcct gccccgggga taccctctac cagccgctgg
     2881 aagtgggaat gctggcgaca gactgtgtct gtttcccacc ttcatagcag gaatcacccg
     2941 gacccgactg gctgggcttc gtgctagcga gggttttctg ggggtgggtc ttggtgatct
     3001 tgtcctatgg ggatctctgc agtggtctca gccacatcct agtatatttt ggctctggag
     3061 gagcaaagct gtatcctgga gttggtctgt gatttgccga cagacttgca ggctgggctc
     3121 agcaaagtcc cccccaaaac ccgcaggtcc tcatgtccag acgctgccag tcctgtcctg
     3181 aaaacagcac gccccaggcc cacagaaccc cccaccctac atttgccttg ggtggagctg
     3241 ggggtggtcc taggactgcg ggtgccctta gctgaagggg gcccgcagaa gcgtgagctg
     3301 ggccgcctgt gggtcattgg aggttcattg agaattgagt cctttggaaa gactaagaaa
     3361 atcaaatttt taaaagttat ttatggcctg ggaaacaatt tgcatttgtc cccaaatacg
     3421 cttagctgtg tgccgcttag aacgatgaga aaccatccct ctgtgtaagc ccgtgccgtg
     3481 tgactcgaag cctagcgccc tccctgcgaa gcatcagacg ccacccagcc ctgggggagg
     3541 cccacgcctg ctggaccaac gcgggttctg gggtgcacag cgccaggtta acgctgaagc
     3601 ctgccccgct gagcccaaga gccgggaggc ctgcgggctg acccagaatc cgatcatgca
     3661 cctgtcctca tgccagcggc tttggctggg gttggtctga agcctgcacg cggcagttct
     3721 ttgttaaaga tctgagggac tcgtcagtcc tagcgtcgcc gcctgcagcc tcttccaagc
     3781 cctgcgtcca gcgagcgtca cagcacaacc tgcaaaaacg gagctgggct gcagctgggg
     3841 ctggcatgga ctttcatttc agagattcgg tttttaagaa gatgcatgcc tagcgtgttc
     3901 tttttttttt ccaatgattt gtaatataca ttttatgact ggaaactttt ttgtacaaca
     3961 ctccaataaa cattttgatt ttaggttctg cctctgagtt tattcctgag gggaagctcg
     4021 agccgggcct ctgccctaat gaagcggatg tctaagaaag atccctccac ccccaaggaa
     4081 aaaggtcact ggctagtgta gctagtgtaa acaggaccca ggcgatgcat gggaccctgc
     4141 cctttttttt ctagtgagcc tccgacgctg ttgcacaagc tgactcttcg tcacgtgatg
     4201 cgaccggctc cgccccggcg gcaacacgct gtatagacgc gccgggtgcc tcgtgcgcat
     4261 gcgcggcagg cccttcggga cgagctggag gcagagcgtg agtacaaagt gatcggcctc
     4321 ggccgacgca gtagcccccc tactccccgg ccaagtcagg gcctccctct tcccgcggag
     4381 tcgcaaccac gggtagctcg tgtaggtaac ggcaggtcca ggcctccgca tgagcggagg
     4441 gccccccgca cgaccttgaa tggcccggtg gcgcgcgcgg tcgtgtggga gttgtagtcc
     4501 tccgtccccg tccgcgcgga ctccgtttcc cgtggtgccc cgggcggccc gcttccggcg
     4561 cagttagtta cgagtcggcg cacgcggcct cggtccggtt gactttgcgg agccatggag
     4621 ggcggcttcg gctccgattt cgggggctcc ggcagcggga agctggaccc agggctcata
     4681 atggagcagg tgaaagtgca gatcgccgtg gccaacgcgc aggagctgct gcaggtgcgg
     4741 ggctggccgg ggacgggcgc tgggggcgac agggccaccc ctaggggccg acgtcgcggc
     4801 taagcctcgc gtgtctccac agaggatgac ggacaagtgt ttccggaagt gtatagggaa
     4861 acctaggggc tccctagaca actccgagca ggtgagaccc gcggaaggtt cggggcaagg
     4921 gtcgcgaggg cctagattcg ggggggaggt gtctgcgcgt gcgagacaac ggggaggtgc
     4981 gacggagtgg tcactgcacg tgcgtagtct gcagcccggg cgtcctggag ccggggttag
     5041 ggcggtcccc ggggccgcga agtcccgagc tgagccgtgc gcccctccgc tcccgcagaa
     5101 gtgcatcgcc atgtgcatgg accgctacat ggacgcctgg aacaccgtgt ctcgcgccta
     5161 caactcgcgg ctgcagcggg aacgagccaa catgtgaccg gcgagcgcgg gccaccccac
     5221 cctgtcattt ccataaacgg tttgagaggc ggggtccgat gtacgtactg cctgcccggg
     5281 gctaggaggg tggcaccggt gctgggacac acgggactgt gtcctcgcca ccccccgccc
     5341 tgccccctgc cagccagtgc agcttggatc tcgggggtgt ggggccctgt gcttcctgaa
     5401 gtgctggcag cccagtggca cctccttcag gcctttgggg tattccccta gtgtgcccaa
     5461 gtcagcctca tattctgggc ggacagcttg tctggacttc ggagttgggg gtggtcagac
     5521 accacaggag ctgtcacctc ctgcggatgg gcaaataaat tggtggagga cggagagaaa
     5581 cctctttatt tcctccttgt ccctggaacc ccagctcgga gggtctcagc ctcccctggg
     5641 ttgggagaag tcatctttcc ccttagtgcc gccgggctgc tgagtcacga ggaatgtgtt
     5701 gctgctgcca cccctgcccc aaaggctaag ggggacagcc ttccccttgt cagggcttgc
     5761 tttgaccctg cttcgttcca ccccgggtcc tggtggagcc accaggcagg tggtcctcgc
     5821 tgtgacactg aggtgctgag ccagtgagct agggtggagg ggctgtgttt ggaacaaagg
     5881 gtggtaccaa aatgcatccc catgacccac agccccccca cacccgtcct tgggtagggt
     5941 acggtggggt ggggtgttgg gtggcctgct gctcctgttg ctttcacgta gagtctcggc
     6001 ctgggcagtc acgtggtggt cactcctgga tgtgctgtcc tatccagcct ctcacagctg
     6061 ccacccgggt atagacacct gggaagtggg gccggccaca gccatagccc cagctagtga
     6121 ccccagttag cacccaccgt ccagagggct ccctgcaacc aggggtcccc cagcgtcacc
     6181 ctgttgggga gagaagaaag ggggttcaga ggccggtacc tcccctacag cagcccttgg
     6241 gtcattggcc cctctaggag tgaccctagt gacttcccct ggagccgcat tttcactatc
     6301 tggaaaatgg gctcaatcaa aggtggcaga catttatgga cacccgctac gtggtcccgg
     6361 agtgaacggt tacctcccac tgcagcctct gcctgctctg ccgccgaggc ccggggatgg
     6421 gatgcggtgg gttgcccaat aaacggctgt ggagtggaaa ttcctccgga gccaaaaagg
     6481 ctccctgctt gatccgctgg agaagcctgc accggagggt ggctcccgga tggtgggctt
     6541 cgtggcagcg ggaacccgcc ctccccggcg gctgggcggg acctggtccc ctgggccggg
     6601 gcggggctca ccgagcagct gtccacgccc cctgcgggaa gccggcacac agcatgcggc
     6661 tgctgatctg cactgggtag aagcggcggc aggtctgctc gctgaggagg cgcacggccg
     6721 ccttctgcag ctgccgcgcc atggagcctg cgggcggcga gcgagacggg gcgggtgggg
     6781 accgcgtccc ggccgccccc cgagtccccg caccaccgcg gtccccgggc gcgcctacct
     6841 ccttcgtcgc accgagcccc agccggtgat gacgcagcgg tgccgtccgg gggtcgcggc
     6901 gcggctaggg caggcagatg ggacgcacca ggcggctgcg acgaccgtac ccc
//