From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse gene for IgE heavy chain constant region
Date: 22 Aug 92 10:01:08 GMT
Distribution: bionet
Checksum: 29910     8

LOCUS       MUSIGEHC     2435 bp ds-DNA             ROD       22-AUG-1992
DEFINITION  Mouse gene for IgE heavy chain constant region
ACCESSION   X01857
KEYWORDS    constant region; epsilon-immunoglobulin; glycoprotein;
            immunoglobulin heavy chain.
SOURCE      Mus musculus DNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Ishida,N., Ueda,S., Hayashida,H., Miyata,T. and Honjo,T.
  TITLE     The nucleotide sequence of the mouse immunoglobulin epsilon gene:
            comparison with the human epsilon gene sequence
  JOURNAL   EMBO J. 1, 1117-1123 (1982)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Honjo,T.
  JOURNAL   Unpublished (1986)
  STANDARD  full automatic
COMMENT     From EMBL    entry MMIGEHC;  dated 10-JAN-1991.
FEATURES             Location/Qualifiers
     mRNA            join(<1..412,1760..>1760)
     CDS             join(142..412,955..1275,1357..1677,1760..2112)
                     /product="immunoglobulin epsilon"
                     /codon_start=1
                     /translation="SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNM
                     STVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLE
                     LLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLAS
                     TCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQ
                     NGAPKLTCLVVDLESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKD
                     WIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQN
                     FFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTC
                     QVIHEALQKPRKLEKTISTSLGNTSLRPS"
                     /partial
     misc_feature    142..412
     misc_feature    142..412
                     /note="CH 1 domain (412 is 1st base in codon)"
     intron          413..954
                     /note="intron I"
     misc_feature    955..1275
     misc_feature    955..1275
                     /note="CH 2 domain (955 is 2nd base in codon) (1275 is 1st
                     base in codon)"
     old_sequence    967
                     /note="a was ca in [1]"
                     /citation=[1]
     old_sequence    971
                     /note="t was tt in [1]"
                     /citation=[1]
     old_sequence    1004
                     /note="c was gc in [1]"
                     /citation=[1]
     old_sequence    1026
                     /note="c was t in [1]"
                     /citation=[1]
     old_sequence    1079
                     /note="t was c in [1]"
                     /citation=[1]
     old_sequence    1225
                     /note="a was g in [1]"
                     /citation=[1]
     intron          1276..1356
                     /note="intron II"
     old_sequence    1331..1333
                     /note="ttc was cct in [1]"
                     /citation=[1]
     misc_feature    1357..1677
     misc_feature    1357..1677
                     /note="CH 3 domain (1357 is 2nd base in codon) (1677 is
                     1st base in codon)"
     old_sequence    1373..1375
                     /note="tgt was cgc in [1]"
                     /citation=[1]
     old_sequence    1484
                     /note="g was c in [1]"
                     /citation=[1]
     old_sequence    1620
                     /note="a was g in [1]"
                     /citation=[1]
     old_sequence    1630
                     /note="a was g in [1]"
                     /citation=[1]
     old_sequence    1668..1671
                     /note="aaga was ctt in [1]"
                     /citation=[1]
     intron          1678..1759
                     /note="intron III"
     misc_feature    1760..2112
     misc_feature    1760..2109
                     /note="CH 4 domain (1760 is 2nd base in codon)"
     mRNA            1760..2085
                     /note=" of IgE membrane bound form"
     CDS             1760..2085
                     /note="CH 4 domain of membrane bound IgE (1760 is 2nd base
                     in codon) (2085 is 1st base in codon)"
                     /codon_start=3
                     /translation="QRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGK
                     LISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEK
                     TISTSL"
                     /partial
     intron          2086..>2435
                     /note="intron IV of membrane bound IgE"
BASE COUNT      676 a    662 c    529 g    568 t
ORIGIN
        1 gaatctaacc atctgtctcc tagactggaa tggggtcccc agagccctgc tcctgtcaca
       61 gctgccctta accagttccc cacgctgcag gtatgtagtg atataaataa gtctaaccta
      121 ggtccttcct ttctcacagc ctctatcagg aaccctcagc tctacccctt aaagccctgt
      181 aaaggcactg cttccatgac cctaggctgc ctagtaaagg actacttccc taatcctgtg
      241 actgtgacct ggtattcaga ctccctgaac atgagcactg tgaacttccc tgccctcggt
      301 tctgaactca aggtcaccac cagccaagtg accagctggg gcaagtcagc caagaacttc
      361 acatgccacg tgacacatcc tccatcattc aacgaaagta ggactatcct aggtaagtag
      421 ggatgggctg acagttacac tgtgtattct cccttggaga tggaacagtt tctgtctaat
      481 caggaacttg tcacaatttc ctttcataga ggacttcata agagattttt tttctacttc
      541 tatcatgttt agtgatccaa atagatttta aaaactggtt gagtgcatat tacttttagc
      601 ctcagaagac atcacgcaca tttaagaggc atttaactat tgtaaattat tctgatgact
      661 taaaaaatgc tcacgactga gtcgtatatt tttaaataaa ttttattagt ttagtttaaa
      721 aaaagaaaag aaaattatta attttattaa aaaatctcct atatttaaaa aaaaaagaga
      781 aaaaggcaga gctgggctgg ctacggttac cacaggaaca tggtcagagg aggaagggac
      841 tcttatacaa cctatgacag gagaacggga gacccaacat actcgggggc ctaccttcag
      901 agaacacaag gccagggcaa tactcacgag accagttgtt cgccctgccc ctagttcgac
      961 ctgtcaacat cactgagccc accttggagc tactccattc atcctgcgac cccaatgcat
     1021 tccactccac catccagctg tactgcttca tttatggcca catcctaaat gatgtctctg
     1081 tcagctggct aatggacgat cgggagataa ctgatacact tgcacaaact gttctaatca
     1141 aggaggaagg caaactagcc tctacctgca gtaaactcaa catcactgag cagcaatgga
     1201 tgtctgaaag caccttcacc tgcaaggtca cctcccaagg cgtagactat ttggcccaca
     1261 ctcggagatg cccaggtagg tctacactcg cctgatgccc agacctcaga gtccctgagg
     1321 gaaaggcagg ttcacacagc ccttcctccc cgacagatca tgagccacgg ggtgtgatta
     1381 cctacctgat cccacccagc cccctggacc tgtatcaaaa cggtgctccc aagcttacct
     1441 gtctggtggt ggacctggaa agcgagaaga atgtcaatgt gacgtggaac caagagaaga
     1501 agacttcagt ctcagcatcc cagtggtaca ctaagcacca caataacgcc acaactagta
     1561 tcacctccat cctgcctgta gttgccaagg actggattga aggctacggc tatcagtgca
     1621 tagtggacca ccctgatttt cccaagccca ttgtgcgttc catcaccaag accccaggtg
     1681 agtacaggag gtggagagtg gccagccctt ctcatgttca gagaacatgg ttaactggtt
     1741 aagtcatgtc gtcccacagg ccagcgctca gcccccgagg tatatgtgtt cccaccacca
     1801 gaggaggaga gcgaggacaa acgcacactc acctgtttga tccagaactt cttccctgag
     1861 gatatctctg tgcagtggct gggggatggc aaactgatct caaacagcca gcacagtacc
     1921 acaacacccc tgaaatccaa tggctccaat caaggcttct tcatcttcag tcgcctagag
     1981 gtcgccaaga cactctggac acagagaaaa cagttcacct gccaagtgat ccatgaggca
     2041 cttcagaaac ccaggaaact ggagaaaaca atatccacaa gccttggtaa cacctccctc
     2101 cgtccctcct aggcctccat gtagctgtgg tggggaaggt ggatgacaga catccgctca
     2161 ctgttgtaac accaggaagc taccccaata aacactcagt gcctgattag agccctgggc
     2221 gcccgttctt cggggaaggc agggttcatg ggcagaaata tctcggcctg aaagaaggga
     2281 cacccaagag aaggacagga gtgaagcacg gctcacccat ctgtctctgt gttgaatatt
     2341 taacacatag gcgtcacagg acttcagcag tggtccttca gcgtcccctg atccttcgct
     2401 gctcttcact ggatatcatg cgcctgatct ctaga
//