From: JIM.DIXON@f240.n353.z1.fidonet.org (JIM DIXON)
Newsgroups: k12.ed.science
Subject: TCDD2
Date: Sun, 20 Dec 92 11:56:00 PDT
Organization: FidoNet node 1:353/240 - The Polish Connecti, Westbank BC

Sampling from IRPTC/UNEP using TCDD as search key. (I suggest you set your
margins to 0 and 80.)
                 IDENTIFIERS, PRODUCTION, PROCESSES AND WASTE
                 IDENTIFIERS
 ..................................................................
 ISN=115
 CHEMICAL NAME:  2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
 COMMON NAME:  TCDD
 RTECS NUMBER: HP3500000 WISWESSER:
 CAS NUMBER: 1746-01-6
 MOLECULAR WEIGHT: 322
 MOLECULAR FORMULA:  C12H4CL4O2
 SYNONYMS: DIBENZO-P-DIOXIN, 2,3,7,8-TETRACHLORO DIOXIN NCI-C03714 TCDBD TCDD
           2,3,7,8-TCDD 2,3,6,7-TETRACHLORODIBENZO-P-DIOXIN (GER)
           2,3,7,8-TETRACHLORODIBENZO-1,4-DIOXIN
 MELTING PT: 305-306C               BOILING PT:
 VP:                                N-OCTOH:AQ:
 AQSOL: 2E-7G/L                          STATE:
 COLOUR: COLOURLESS                      ODOUR:
 SURF TEN:                               TASTE:
 FAT.SOL:
 0.57G/L IN BENZENE; 0.04G/L IN LARD OIL
 PARTICLE:EXTREMELY STABLE EVEN ON HEATING TO 700C
=============================================================================
                       CONCENTRATIONS
                       CONCENTRATION DATABASE
ISN=2001
   RTECS-NO: HP3500000   SUBSTANCE: TCDD
CAS NUMBER: 1746-01-6
...............TEST DESCRIPTION.........    ............TEST CONDITIONS.......
ORGANISM: FISH                              STUDY TYPE:
          CRUS
LIFESTAGE, AGE:          GEOG. AREA: VNM
SPECIFICATION: RIVER
SEX:
MEDIUM: AQ
SAMPLE SIZE:
TEST-SUB: -
SPECIES-STRAIN-SYSTEM: FISH FROM THE DONG NAI RIVER AND PRAWNS FROM SAIGON RIVER
                       3-4 MONTHS AFTER SPRAYING OF HERBICIDES WAS STOPPED IN
                       VIETNAM
TEST METHOD: GC-MS
COMMENTS:    IN VIETNAM, LEVELS TENDED TO BE HIGHER IN FISH FROM INTERIOR RIVERS
             THAN IN THOSE FROM SEACOAST LOCATIONS. FOR COMPARISON 3NG/KG WAS
             FOUND IN FISH FROM A MARKET IN MASSACHUSETTS, (USA).
EVALUATION APPRAISAL:
UNPUB--EVALUATED....REFERENCE.VOLUME..........PAGE.PAGE.....YEAR.............
         PRIMARY:  EVHPAZ    5                    27       1973
         SECONDARY: IARMB8    15                   56       1977
          PRIM. AUTHOR : BAUGHMAN,R.W. & MESELSON,M.
          SECND. AUTHOR: IARC
..............................................................................
ORGAN  CONC1      CONC2      UNIT   SPEC       MO1 YR1  MO2 YR2  COMMENTS
       49         49         NG/KG-              0        0    IN PRAWNS
       1020       1020       NG/KG  -              0        0    IN FISH
============================================================================
                       CARCINOGENICITY
                       CARCINOGENICITY DATABASE
ISN=300
   RTECS-NO: HP3500000   SUBSTANCE:  TCDD
   CAS NUMBER: 1746-01-6
...............TEST DESCRIPTION.........    ............TEST CONDITIONS.......
   ORGANISM: MOUSE                         STUDY TYPE: LAB
   LIFESTAGE ,AGE:                    PURITY:
   SEX/NUMBER EXPOSED:  F 50/DOSE
                        M 50/DOSE
   CONTROL:  125TOT 125TOT
   EXPOSURE:TYPE: LONG
            PERIOD:   LOW: 104       HIGH: 104        UNIT: WK
            ROUTE:
            DOSE:     LOW:0.01       HIGH:2           UNIT:UG/KG  SPEC:WK
            FREQUENCY:LOW:2          HIGH:2           UNIT:D/WK
   SPECIFICATION:
   SPECIES-STRAIN-SYSTEM:     B6C3F1 MICE
   EXPOSURE COMMENTS: MALES RECEIVED 0.01, 0.05 AND 0.5UG/KG/WK. FEMALES
                      RECEIVED 0.04, 0.2, OR 2UG/KG/WK
   IMPURITIES:
   TEST-CONDITIONS:
   TEST METHOD:  ALL SURVIVING ANIMALS KILLED AT 105-108WK
   COMMENTS:
   EVALUATION APPRAISAL:
   VEHICLE SOLVENT: 9:1 CORN OIL-ACETONE
   TEST SUBST/PARTICLE SIZE:
...EVALUATED........REFERENCE.VOLUME..........PART.PAGE.....YEAR.............
           PRIMARY: DPNSDO    209                  13       1982
        SECONDARY:
          PRIM. AUTHOR :
          SECND. AUTHOR:
...............EFFECT........................
   ORGANEFFECT REV    ONSET  SEX-AFFECTED  CONTROL    COMMENTS ON RESULT.
   .....  ...... ...    .....  ............  .......    .....................
   LIVER  CAR                  M   18%       11%        HEPATOCELLULAR
               CARCINOMAS IN MALES AT
                                                        0.01UG/KG.
   LIVER  CAR                  M   16%       11%        HEPATOCELLULAR
                                                        CARCINOMAS IN MALES AT
                                                        0.05UG/KG.
   LIVER  CAR                  M   34%       11%        HEPATOCELLULAR
                                                        CARCINOMAS IN MALES AT
                                                        0.5UG/KG.
   LIVER  CAR                  F   4%        1%         HEPATOCELLULAR
                                                        CARCINOMAS IN FEMALES AT
                                                        0.04 AND 0.2UG/KG.
   LIVER  CAR                  F   13%       1%         HEPATOCELLULAR
                                                        CARCINOMAS IN FEMALES AT
                                                        2UG/KG.
   ENDOC  NEO                  F   6%        0%         THYROID FOLLICULAR-CELL
                                                        ADENOMAS IN FEMALES AT
                                                        0.04UG/KG.
   ENDOC  NEO                  F   11%       0%         THYROID FOLLICULAR-CELL
                                                        ADENOMAS IN FEMALES AT
                                                        2UG/KG.
   LIVER  INFL                                          TOXIC HEPATITIS AT HIGH
                                                        DOSE IN BOTH SEXES
=============================================================================
I hope this gives you an idea of the data available Olivia.  You, or your
classmates should feel free to ask for any data.  If the resulting 'hits'
are too large, I'll send them out as a text file on a 360k IBM compatible
floppy. No charge.
___ Blue Wave/QWK v2.11
                                                                                                                        

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