From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human azurocidin gene, complete cds.
Date: 31 Dec 92 01:37:11 GMT
Distribution: bionet
Checksum: 12733 10

LOCUS       HUMAZCDI     5002 bp ds-DNA             PRI       17-DEC-1992
DEFINITION  Human azurocidin gene, complete cds.
ACCESSION   M96326
KEYWORDS    azurocidin.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5002)
  AUTHORS   Morgan,J.G., Sukiennicki,T., Pereira,H.A., Spitznagel,J.K.,
            Guerra,M.E. and Larrick,J.L.
  TITLE     Cloning of the cDNA for the serine protease homolog
            CAP37/azurocidin, a microbicidal and chemotactic protein from human
            granulocytes
  JOURNAL   J. Immunol. 147, 3210-3214 (1991)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 5002)
  AUTHORS   Zimmer,M., Medcalf,R.L., Fink,T.M., Mattmann,C., Lichter,P. and
            Jenne,D.E.
  TITLE     Three human elastase-like genes co-ordinately expressed in the
            myelo-monocyte lineage are organized as a single genetic locus on
            19pter
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 8215-8219 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mRNA            join((237.241)..310,636..792,2002..2146,3148..3381,
                     4156..>4458)
                     /standard_name="azurocidin mRNA"
                     /partial
     mat_peptide     join(656..792,2002..2146,3148..3381,4156..4314)
                     /product="azurocidin"
                     /codon_start=1
     sig_peptide     join(253..310,636..655)
                     /codon_start=1
     GC_signal       complement(28..33)
     CAAT_signal     137..142
     GC_signal       179..184
     TATA_signal     212..216
     exon            (237.241)..310
                     /number=1
                     /label=exon1
     CAAT_signal     237..242
     conflict        replace(250,"")
                     /citation=[1]
                     /note="'C' in conflict"
     conflict        replace(297,"")
                     /citation=[1]
                     /note="'G' in conflict"
     intron          311..635
                     /number=1
     exon            636..792
                     /number=2
                     /label=exon2
     intron          793..2001
                     /number=2
     exon            2002..2146
                     /number=3
                     /label=exon3
     intron          2147..3147
                     /number=3
     repeat_region   complement(2246..2369)
                     /rpt_family="'Alu'"
     repeat_region   2417..2703
                     /rpt_family="'Alu'"
     repeat_region   complement(2895..3014)
                     /rpt_family="'Alu'"
     exon            3148..3381
                     /number=4
                     /label=exon4
     intron          3382..4155
                     /number=4
     repeat_region   complement(3525..3810)
                     /rpt_family="'Alu'"
     exon            4156..>4458
                     /number=5
                     /label=exon5
     conflict        replace(4380,"")
                     /citation=[1]
                     /note="'' in conflict"
     repeat_region   4661..4951
                     /rpt_family="'Alu'"
     CDS             join(253..310,636..792,2002..2146,3148..3381,4156..4317)
                     /product="azurocidin"
                     /codon_start=1
                     /translation="MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASI
                     QNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSM
                     SENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSG
                     GRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFS
                     LGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA"
BASE COUNT     1089 a   1268 c   1771 g    874 t
ORIGIN      
        1 ggatccactg gttcctgaca ccctcacctg cccctggggg tgtggccatc ttctagagag
       61 ggaaactgag gatcagtgca gaatgtaggg ggagcccagg ctggcccagg gagcagttgg
      121 cggtggaggc cttgggcaat ttcccgtgtt cccactgagt ggggctgtcc ctgggcctgg
      181 gcggggacgc caccaactgc caaggcctgt gtataagggc agccgccgcc ttagccacag
      241 acctgccccg ccatgacccg gctgacagtc ctggccctgc tggctggtct gctggcatcc
      301 tcgagggccg gtgagtgcct ctctgtgccg gtggtccccc atctgtgcta gggcccggct
      361 gccagggcag aactcagact taaagcacag agaaggcaag cggcttggcc tgggtcacac
      421 agccagcccg gcctggacga tcccgcgaaa ggcgtgaggg cggacggtgt gcgggactca
      481 ggggccccct gtcctcttag ggagtgggac gatgggggag ggtgggtccc cccgcagccc
      541 cactgggtgg atagagctga ggctgcagct tcacacgccc tcccggccac tgtgtggatt
      601 cttggggatc tcagagctgt ctccccccga cccaggctcc agcccccttt tggacatcgt
      661 tggcggccgg aaggcgaggc cccgccagtt cccgttcctg gcctccattc agaatcaagg
      721 caggcacttc tgcgggggtg ccctgatcca tgcccgcttc gtgatgaccg cggccagctg
      781 cttccaaagc cagtgagggg tcctggggag ggggcctagg gggcattggg gctcagagaa
      841 ggggcttggg gggcttaggc attcagtggg ggtgcttggt aggtgaggag gggaggggat
      901 tgcaaaagga ggggctcagg gaaaggaggg ggcttggaga gggaaatggg gactgagttg
      961 aggagggacc caaggatatt ggggggctca gatggaggag gcccagagaa gggaaggggg
     1021 tcagatggag gaggcccaga gaaaggaaga ggctcagatg gaggaggtgc agtgaaggaa
     1081 agggggtcag atgggggagg cccagagaag ggaaggggct cagatggagg agggggccca
     1141 gagaaaggaa ggggctcaga tggaggaggt gcagagaagg gaagggggtc agatgggggg
     1201 aggcccagag aagggaaggg gctcagatgg aggaggtgca gagaagggaa ggggctcaga
     1261 tggaggaggt gcagagaaga gaagggcctc agatggagga ggtgcagaga agagaagggc
     1321 ctcagatgga ggaggtgcag agaagggaag ggcctcagat ggaggaggtg cggagaaggg
     1381 aagggggtca gatggaggag gtgcagagaa gggaaggggg tcagatgggg gaggcccagg
     1441 gaagggaagg ggctcagatg gaggaggggc agagaaggga agggggtcag atgggggagg
     1501 cccagggaag ggaaggggct cagatggggg aggcgcagag aagggaaggg ggtcagatgg
     1561 aggaggtgca gagaagggaa gggggtcaga tgggggaggc ccagataagg gaatggggtc
     1621 agatggggga ggtgcagaga agggaagggg gtcagatggg ggaggcccag ataagggaag
     1681 gggctcagat ggaggaggtg cagagaaggg gagggggtca gatggaggag gctcagagaa
     1741 gggaagggac tcagatggag gagggggcgc agagaagaga aggggctcag atggaggagg
     1801 aggcgcagag aagggaaggg gctcaagatg ggaagggggc cctggaaagt ctcggctctg
     1861 cttctgtaaa agcgggggag ttttcagggt gaaggattgc agtctgcagg ctgggatccc
     1921 ccctaatttg caagccggct tgctctgtgc ccaggcccca gcctggtgtc ctccctctgc
     1981 cctttcctcc gctactctca ggaaccccgg ggttagcacc gtggtgctgg gtgcctatga
     2041 cctgaggcgg cgggagaggc agtcccgcca gacgttttcc atcagcagca tgagcgagaa
     2101 tggctacgac ccccagcaga acctgaacga cctgatgctg cttcaggtga gaggatggtg
     2161 ccacctgtga tcccagcacc tcgggaggcc gacgttagcc agggaaacaa gtccaaactt
     2221 ggtctctaca aaaaaataca aaaattagcc gggagtggtg gcgcgcacct gtggcccctg
     2281 tgcttcagga ggccgaggcg gaaggacggc ttgaggtcag gagttcgaga ccagcctggg
     2341 caacatggcc aaactcagtc tctacaaaaa tatatatgtg tgtgtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg tgtgtatctt gccgggtgag gtggctcatg cctgtaatcc cagcattttg
     2461 ggaggccgag gtgggcggat cacgaggtca ggagattgag accagcctgg ccaacatggt
     2521 gaaaccccat ctctactaaa aatacaaaaa ttagccaggc atggcagcgg gcgcctctag
     2581 tcccagctac tcaggaggct gaggcaggag aatcgcttga acccgggagg cggagcttgc
     2641 agtgagccga gatcgcgccc ctgcactcca gcctgggtaa cagagccaga ccctatctca
     2701 aaaaaaactt ccaaaaacaa tacagcaaca catacagatg taccacggtt cgcgtatgga
     2761 gcctcctgtt ggtggagact gacgtcgttt tcaaatgctt ttgctatgac agaatcatgt
     2821 gaatgttttt catgtttggt ttttttcttt gagaaaatga taaaattatc tcaaaaatat
     2881 cattaaaaaa tttaaaaaag tagagacggg ggtttcacct tgttggccag tttggtctcg
     2941 aactcctggc ctcaagtgat ccacccacct tggcctcgca acgtgctggg aatacaggcg
     3001 tgagccaccg cacccggccc ctgccgggaa ttaaacgcaa accacttaca gactacagtt
     3061 aatgtcgctg acacttctgc tcccaggggt ccccatgagg ctccagtccc cagggccacc
     3121 ctcccctgac tccatttcct tccccagctg gaccgtgagg ccaacctcac cagcagcgtg
     3181 acgatactgc cactgcctct gcagaacgcc acggtggaag ccggcaccag atgccaggtg
     3241 gccggctggg ggagccagcg cagtgggggg cgtctctccc gttttcccag gtttgtcaac
     3301 gtgactgtga cccccgagga ccagtgtcgc cccaacaacg tgtgcaccgg tgtgctcacc
     3361 cgccgcggtg gcatctgcaa tgtgagtgct ccctgtggcg ggaggagggg tcctgagagg
     3421 tactgagctc tccgtggcag gagaaagcaa gtgcaggctg agggcggcac agcagggggg
     3481 ccccaggatt gagcattttc acggtaggag aaacagtatc tttttttttt tttttgagac
     3541 agagtctcgc tctgtcgccc aggctggagt gtagtggcgt gatctcggcg gctcactgca
     3601 acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctaagta gctgggatta
     3661 caggcatgcg ccaccacgcc cggctaattt tgtattttta gtagagacag ggtttctcca
     3721 tgtgggtcag gctggtctcg aactcctgac ctcatgatcg acccaccttg gcctcccaaa
     3781 gtgttaggat aacaggcatg agccaccgtg cctggctgag aaacagtagc tatcaaacgc
     3841 cggctgtgag ccacgtctgt gctgggggtt ggggacccag caggcatggt agagccggtc
     3901 actgagggac tcaggcgtgt gattgccagg ggaggggcac ctggcccagc ctggaggtgc
     3961 caggaagctc cagaaagcaa ctgatcccaa agtccactag cagttaacca gggcagagaa
     4021 agagaagagc catgcaaagg ccctggggct ggatcaggac ttgtaggttc caggggcagc
     4081 aagaggcctc tgcagttctg gggtggcgtg ggagccaggc cctgggacgc cctgacacag
     4141 ctgctgcctg cccaggggga cgggggcacc cccctcgtct gcgagggcct ggcccacggc
     4201 gtggcctcct tttccctggg gccctgtggc cgaggccctg acttcttcac ccgagtggcg
     4261 ctcttccgag actggatcga tggtgttctc aacaacccgg gaccggggcc agcctagggg
     4321 ggcctgtgac ctcccatgga gcccagcccc cgccctccac acctccggcg ctccgcaccc
     4381 acctcccacg gccccgcccc tgcccccgct ccggccagag gggccctggc tgtaataaag
     4441 aagccgatct ctcctctgct cctggtttct gttcattggt gggggagggg gctgtgggga
     4501 cgcgtgagtg gcaccttcac cggccttagg ggcacccacc gcaggtgcac tgcctgtgca
     4561 gatgtcagat gttcagagat tccctcaaag cccggggaag caggggctgg tgttatctgc
     4621 acccgacagc ggggtgttgg ggggaggccc aggttcagag aggttgggtg gctgcccaga
     4681 ggtcacacag tgaatgccgc ccagcacttt gggaggccga ggtgggcgga tcacctgagg
     4741 tcaggagttc aagaccagcc cggccaacct ggtgaaaccc catctctata aaaatacaaa
     4801 aattagccgg gcatgatggc gggcgcctgt aatcccagtt acttgggagg ctgaggcagg
     4861 agaatcacct gaacccggga ggcggaggtt gcagcgaacc gagatggcgc cactgcactc
     4921 cagcctgggc gacagcgaga ctccagctca aaaaaaaaca aaaaccacgg gagaaaacgg
     4981 ggaacattct cctcttggat cc
//