From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human T-cell receptor germline gamma-chain gene V-region (V2;
Date: 7 Jan 93 05:51:39 GMT
Distribution: bionet
Checksum: 04654 4

LOCUS       HUMTCGVA2     525 bp ds-DNA             PRI       06-JAN-1993
DEFINITION  Human T-cell receptor germline gamma-chain gene V-region (V2;
            subgroup I).
ACCESSION   M13429
KEYWORDS    T-cell antigen receptor; T-cell receptor gamma-chain; germline;
            variable region.
SEGMENT     2 of 7
SOURCE      Human B-lymphoblastoid cell line SH DNA, clones lambda-SH4 and
            lambda-SH2.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Lefranc,M.-P., Forster,A., Baer,R.J., Stinson,M.A. and
            Rabbitts,T.H.
  TITLE     Diversity and rearrangement of the human T cell rearranging gamma
            genes: Nine germ-line variable genes belonging to two subgroups
  JOURNAL   Cell 45, 237-246 (1986)
  STANDARD  full automatic
COMMENT     Printed copy of the sequence in [1] was kindly provided by
            M.-P.LeFranc, 01-AUG-1986.  Entry revisions for [1] also kindly
            provided by M.-P. Lefranc, 22-JUN-1988.
FEATURES             Location/Qualifiers
     exon            <1..43
                     /number=1
                     /product="T-cell receptor gamma-chain"
                     /gene="TCRGV2"
                     /note="V2 region"
     intron          44..154
                     /gene="TCRGV2"
                     /note="V2 gamma intron A"
     exon            155..465
                     /number=2
                     /product="T-cell receptor gamma-chain"
                     /gene="TCRGV2"
                     /note="V2 region"
     iDNA            (465.467)..>525
                     /gene="TCRGV2"
                     /note="V-J intervening DNA"
     misc_signal     466..472
                     /note="heptamer recombination signal; putative"
     misc_signal     496..504
                     /note="nonamer recombination signal; putative"
     CDS             join(<1..43,155..465)
                     /gene="TCRGV2"
                     /partial
                     /note="V2 region"
                     /product="T-cell receptor gamma-chain"
                     /codon_start=1
                     /translation="MQWALAVLLAFLSPASQKSSNLEGRTKSVIRQTGSSAEITCDLA
                     EGSNGYIHWYLHQEGKAPQRLQYYDSYNSKVVLESGVSPGKYYTYASTRNNLRLILRN
                     LIENDSGVYYCATWDG"
BASE COUNT      131 a    123 c    128 g    143 t
ORIGIN      About 3.3 kb after segment 1; chromosome 7.
        1 atgcagtggg ccctagcggt gcttctagct ttcctgtctc ctggtgagtg cgctgcctac
       61 agagaggatc acgggttttg ttttattttc ttcttttgca aggagtacca tactaaggaa
      121 ttcctcatta tattttgtgt tgttcccact gcagccagtc agaaatcttc caacttggaa
      181 gggagaacga agtcagtcat caggcagact gggtcatctg ctgaaatcac ttgtgatctt
      241 gctgaaggaa gtaacggcta catccactgg tacctacacc aggaggggaa ggccccacag
      301 cgtcttcagt actatgactc ctacaactcc aaggttgtgt tggaatcagg agtcagtcca
      361 gggaagtatt atacttacgc aagcacaagg aacaacttga gattgatact gcgaaatcta
      421 attgaaaatg actctggggt ctattactgt gccacctggg acgggcacag tgattcagat
      481 ccgccctaca ccacactgaa aatctgcctt gtggctgctt ctggt
//