From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human neutrophil oxidase factor (p67-phox) mRNA, complete cds.
Date: 5 Nov 92 23:12:00 GMT
Distribution: bionet
Checksum: 43317 5

LOCUS       HUMNOXF      2206 bp ss-mRNA            PRI       15-SEP-1990
DEFINITION  Human neutrophil oxidase factor (p67-phox) mRNA, complete cds.
ACCESSION   M32011
KEYWORDS    neutrophil oxidase factor.
SOURCE      Human promyelocytic leukemia myeloid cell line HL60, cDNA to mRNA,
            clone 10.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Leto,T.L., Lomax,K.J., Volpp,B.D., Nunoi,H., Sechler,J.M.,
            Nauseef,W.M., Clark,R.A., Gallin,J.I. and Malech,H.L.
  TITLE     Cloning of a 67kD neutrophil oxidase factor with similarity to a
            noncatalytic region of P60-c-src
  JOURNAL   Science 248, 727-730 (1990)
  STANDARD  full automatic
COMMENT     Draft entry and computer-readable sequence [1] kindly submitted by
            H.L.Malech, 08-FEB-1990.
FEATURES             Location/Qualifiers
     mRNA            <1..2206
                     /note="p67-phox"
     polyA_signal    2030..2035
     polyA_signal    2181..2186
     CDS             68..1648
                     /product="neutrophil oxidase factor"
                     /codon_start=1
                     /translation="MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIG
                     CMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLR
                     GNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKID
                     KAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFA
                     PLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDN
                     WATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGKPQLSPG
                     QKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKL
                     SYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQ
                     TTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPK
                     VFVEDCATTDLESTRREV"
BASE COUNT      624 a    499 c    573 g    510 t
ORIGIN      
        1 ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta
       61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga
      121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg
      181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa
      241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg
      301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt
      361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct
      421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa
      481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa
      541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc
      601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta
      661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc
      721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag
      781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga
      841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc
      901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga
      961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc
     1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa
     1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta
     1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat
     1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga
     1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa
     1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga
     1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa
     1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt
     1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga
     1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga
     1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat
     1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca
     1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga
     1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat
     1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct
     1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt
     1981 aaacattcat caagctgtac atttggtgca cttttctgtg tcataccaca ataaaaaaaa
     2041 acctatcatc atcttacaaa aacaagacac ccaagtccag gcccaaggag taagtacaaa
     2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg
     2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc
//