HDTenEightyP/NetNews huggingface dataset:
From: eepee@polaris.utu.fi (Esa-Pekka P{lvim{ki)
Subject: Re: Lastest on Halperidol?
Organization: University of Turku, Finland
Distribution: bionet
Date: Mon, 4 Jan 93 14:49:15 GMT

In article <00965C2D.9AF79940.29848@hal.hahnemann.edu> druhanj@HAL.HAHNEMANN.EDU writes:
>Haloperidol also appears to be a high-affinity ligand at sigma binding sites.
>In fact, the term "haloperidol-sensitive sigma receptor" has recently been
>coined to describe a subclass of sigma sites that appear to be distinct from
>other PCP- or opiate-associated sites. 

Could someone shed light on the distribution of sigma receptors in the (rat
or human) brain, especially the haloperidol-sensitive sigma receptors?

/ep
From: wcalvin@stein.u.washington.edu (William Calvin)
Newsgroups: bionet.neuroscience
Subject: Re: Schizophrenia and the immune system
Date: 9 Jan 1993 17:49:55 GMT
Organization: University of Washington
Distribution: usa
NNTP-Posting-Host: stein.u.washington.edu

mitchm@casbah.acns.nwu.edu (Mitchell Maltenfort) writes:
>	I was recently watching a PBS "Frontline" on schizophrenia, and was
>struck by an idea when it was mentioned that schizophrenics have certain
>white blood cell abnormalities.  Is it possible that schizophrenia is an
>autoimmune disease?
>	There is some precedent for this: myasthenia gravis is an autoimmune
>disease in which the immune system targets the neurotransmitters that activate
>muscle.  Might schizophrenia be the result of the immune system interfering
>with the brain functions? ....

Several investigators have hypothesized that it's a result of viral
infections and cite birth seasonality (more born in the winter than in any
other season).  Certainly any autoimmuine reaction affecting dopamine
receptor regulation would be a candidate.
    William H. Calvin   WCalvin@U.Washington.edu
From: anderson@CSHL.ORG (John Anderson)
Newsgroups: bionet.neuroscience
Subject: three-dimensional functional imaging
Date: 11 Jan 93 12:34:09 GMT
Distribution: bionet

I would like some information about techniques for doing
three-dimensional functional imaging of brain activity in animals and
also in humans.  Optical imaging and magnetic resonance imaging appear
to be the methods that provide the highest spatial and temporal
resolution.  What are the best spatial and temporal resolutions that
can be measured simultaneously?  Can they be improved?  Are there
other imaging techniques that could offer similar resolution?

I will post a summary of the responses.  Thanks for your help.

John
-------
John E. Anderson
W. M. Keck Structural Biology Laboratory
Cold Spring Harbor Laboratory
Newsgroups: bionet.neuroscience
From: danj@welchgate.welch.jhu.edu (Dan Jacobson)
Subject: Re: Acetylcholinesterase-Alzheimers Question?????
Organization: Johns Hopkins Univ. Welch Medical Library
Date: Wed, 6 Jan 1993 18:02:18 GMT

pmuniyap@magnus.acs.ohio-state.edu writes:

>     Is there any evidence to support that the neuro-enzyme
>Acetylcholinesterase (AChE) is associated with any diseases?  For eg,
>Alzheimers Disease.  I have just started a research project involving AChE and
>I am curious of the potential for continued research in this area.

This is a good question to ask the database known as ONLINE MENDELIAN 
INHERITANCE IN MAN (OMIM).  There are several ways that you can access
this database.  Probably the easiest is by Gopher or Wais.  If you have
gopher, point it at merlot.welch.jhu.edu (port 70).  Go to the

13. Search Databases at Welchlab (Cloning Vectors, Euk. Promoters, NRL_3D, OMIM)

directory and select the following search - 

 -->  5.  OMIM - Online Mendelian Inheritance Man <?>

A search with the word Acetylcholinesterase returns the following entries:

 -->  1.  *100740 ACETYLCHOLINESTERASE [ACETYLCHOLINE ACETYLHYDROLASE; ACHE].
      2.  100680 ACETYLCHOLINESTERASE EXPRESSION [ACEE; REGULATOR OFACETYLC.
      3.  254190 MYASTHENIA, CONGENITAL, REFRACTORY TO ACETYLCHOLINESTERASE.
      4.  #112100 BLOOD GROUP--Yt SYSTEM [YT; CARTWRIGHT].
      5.  *177400 PSEUDOCHOLINESTERASE, E(1) [CHE1; BUTYRYLCHOLINESTERASE;B.
      6.  *254210 MYASTHENIA GRAVIS, FAMILIAL INFANTILE [FIMG; MYASTHENIA,C.
      7.  *114836 CARBOXYLESTERASE, LIVER.
      8.  *118503 CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA POLYPEPTI.
      9.  *178630 PULMONARY SURFACTANT APOPROTEIN PSP-A [PSAP; SURFACTANT-A.

Now you can select the desired entries, read them and save them on your machine
if you'd like.

If you'd rather connect by Wais the source is as follows:

(:source
   :version  3
   :ip-address "128.220.59.10"
   :ip-name "welchlab.welch.jhu.edu"
   :tcp-port 210
   :database-name "omim"
   :cost 0.00
   :cost-unit :free
   :maintainer "francois@welch.jhu.edu"
   :subjects "science genetics medicine chromosomes biology mendelian"
)



Best of luck,

Dan Jacobson

danj@welchgate.welch.jhu.edu
From: GSBS1032%UTSPH.THENET@LIB.TMC.EDU
Newsgroups: bionet.neuroscience
Subject: Question about Circadian Clock Genes
Date: 12 Jan 93 00:30:57 GMT
Distribution: bionet


	Dear Sirs,
	A few recent publications in Science (1992, 255:1581-1584;
1992, 258: 238-240; 1988, 241: 1225-1227) give some information about
genes and mutations affecting circadian rhythms in Drosophila and mammals.
Does anybody know any reviews on this topic? If you know any other referenices
that could tell about particular details of such stidies, could you please
tell about them?

					Sincerely yours,
					Julia Krushkal
					GSBS/UTSPH
					P.O.B.20334
					Houston, TX 77225   

					gsbs10322utsph.bitnet
Newsgroups: bionet.neuroscience
From: FRICHARD@biomed.med.yale.edu (Frank Richardson)
Subject: Synaptic organization of the hypothalamus
Organization: very little
Date: Sun, 10 Jan 1993 07:20:33 GMT
X-News-Reader: VMS NEWS 1.20

Greetings:
I am working on a proposal for further elucidating the synaptic organization
of the hypothalmus as my qualifying exam. Specifically, I am focusing on the
paraventricular nucleus (PVN) and possibly the supraoptioc nucleus (SON). I am
interested in exploring the question of how specific bursting rhythms in these
nuclei are generated and modulated either by synaptic inputs or endogenous
mechanisms. Although there are a number a recent papers describing the
physiology of single cells and anatomical studies showing GABAergic and
glutamatergic innervation of these regions, little is available on specific
cell-cell interactions (and the appropriate neurotransmitters involved). Does
anyone have any recent information relating to these issues? There is also the
problem of the antidromic inhibition observed as a possible indication of
recurrent inhibition. As far as I can tell, it is still not known whether this
is indeed recurrent inhibition (either from the neurosecratory cell axon
collaterals or via an interneuron) or an intrinsic property of the SON and PVN
neurons. Does anyone have any info on this topic?
Any comments or references would be greatly appreciated! 
Thanks,
Frank Richardson

####################################################################
Usual home of my sphere of consciousness:           "I drank what?"
frichard@biomed.med.yale.edu                      -Attributed to
frichard@yalmed.bitnet                              Socrates,399B.C.
#####################################################################
Newsgroups: bionet.neuroscience
From: pmuniyap@magnus.acs.ohio-state.edu (Pravin K Muniyappa)
Subject: Acetylcholinesterase-Alzheimers Question?????
Keywords: Acetylcholinesterase, AChE
Organization: The Ohio State University
Date: Wed, 6 Jan 1993 17:20:05 GMT

HI,
     Is there any evidence to support that the neuro-enzyme
Acetylcholinesterase (AChE) is associated with any diseases?  For eg,
Alzheimers Disease.  I have just started a research project involving AChE and
I am curious of the potential for continued research in this area.
                                                  Regards,
                                                    Muniyappa
--

-------------------------------------------------------------------------------
|  Pravin (If you can't do it right, do it now) Muniyappa                     |
|  The Ohio State University- Yet another pahhhty skuuuuuul                   |
|  pmuniyap@magnus.acs.ohio-state.edu                                         |
|  Don't try to understand me....Just simply do the things I say              |
-------------------------------------------------------------------------------
Newsgroups: bionet.neuroscience,comp.ai.neural-nets,sci.cognitive
From: erwin@trwacs.fp.trw.com (Harry Erwin)
Subject: Presentation Available
Organization: TRW Systems Division, Fairfax VA
Date: Fri, 8 Jan 1993 14:32:20 GMT

The following is available via surface mail if you want a copy:
"Social System Dynamics: Memes, Genes, and Neural Networks"
To be presented by Harry Erwin to the First Interdisciplinary
Conference on Evolutionary Systems, January 16, 1993

-- 
Harry Erwin
Internet: erwin@trwacs.fp.trw.com

Newsgroups: bionet.neuroscience
From: andrew@uaneuro.uah.ualberta.ca (Andrew Penn)
Subject: Re: Acetylcholinesterase-Alzheimers Question?????
Reply-To: euro.uah.ualberta.ca (Andrew Penn)
Organization: University Of Alberta, Edmonton Canada
Date: Fri, 8 Jan 1993 00:55:23 GMT

In article <1993Jan6.180218.9721@welchgate.welch.jhu.edu>  
danj@welchgate.welch.jhu.edu (Dan Jacobson) writes:
> pmuniyap@magnus.acs.ohio-state.edu writes:
> 
> >     Is there any evidence to support that the neuro-enzyme
> >Acetylcholinesterase (AChE) is associated with any diseases?  For eg,
> >Alzheimers Disease.  I have just started a research project involving  
AChE and
> >I am curious of the potential for continued research in this area.
> 
> This is a good question to ask the database known as ONLINE MENDELIAN 
> INHERITANCE IN MAN (OMIM).  There are several ways that you can access
> this database.  Probably the easiest is by Gopher or Wais.  If you have
> gopher, point it at merlot.welch.jhu.edu (port 70).  Go to the
> 
> 13. Search Databases at Welchlab (Cloning Vectors, Euk. Promoters,  
NRL_3D, OMIM)
> 
> directory and select the following search - 
> 
>  -->  5.  OMIM - Online Mendelian Inheritance Man <?>
> 
> A search with the word Acetylcholinesterase returns the following  
entries:
> 
>  -->  1.  *100740 ACETYLCHOLINESTERASE [ACETYLCHOLINE ACETYLHYDROLASE;  
ACHE].
>       2.  100680 ACETYLCHOLINESTERASE EXPRESSION [ACEE; REGULATOR  
OFACETYLC.
>       3.  254190 MYASTHENIA, CONGENITAL, REFRACTORY TO  
ACETYLCHOLINESTERASE.
>       4.  #112100 BLOOD GROUP--Yt SYSTEM [YT; CARTWRIGHT].
>       5.  *177400 PSEUDOCHOLINESTERASE, E(1) [CHE1;  
BUTYRYLCHOLINESTERASE;B.
>       6.  *254210 MYASTHENIA GRAVIS, FAMILIAL INFANTILE [FIMG;  
MYASTHENIA,C.
>       7.  *114836 CARBOXYLESTERASE, LIVER.
>       8.  *118503 CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA  
POLYPEPTI.
>       9.  *178630 PULMONARY SURFACTANT APOPROTEIN PSP-A [PSAP;  
SURFACTANT-A.
> 
> Now you can select the desired entries, read them and save them on your  
machine
> if you'd like.
> 
> If you'd rather connect by Wais the source is as follows:
> 
> (:source
>    :version  3
>    :ip-address "128.220.59.10"
>    :ip-name "welchlab.welch.jhu.edu"
>    :tcp-port 210
>    :database-name "omim"
>    :cost 0.00
>    :cost-unit :free
>    :maintainer "francois@welch.jhu.edu"
>    :subjects "science genetics medicine chromosomes biology mendelian"
> )
> 
> 
> 
> Best of luck,
> 
> Dan Jacobson
> 
> danj@welchgate.welch.jhu.edu


Most of these references refer to AChesterase in the peripheral nervous  
system, not the CNS.

Andrew Penn
From: lmk2@garnet.berkeley.edu (Leslie Kay)
Newsgroups: bionet.neuroscience
Subject: Re: Schizophrenia and the immune system
Date: 9 Jan 1993 20:32:22 GMT
Organization: University of California, Berkeley
Distribution: usa
NNTP-Posting-Host: garnet.berkeley.edu

In article <1993Jan9.162914.11756@news.acns.nwu.edu> mitchm@casbah.acns.nwu.edu (Mitchell Maltenfort) writes:
>
>	I was recently watching a PBS "Frontline" on schizophrenia, and was
>struck by an idea when it was mentioned that schizophrenics have certain
>white blood cell abnormalities.  Is it possible that schizophrenia is an
>autoimmune disease?
>
>	There is some precedent for this: myasthenia gravis is an autoimmune
>disease in which the immune system targets the neurotransmitters that activate
>muscle.  Might schizophrenia be the result of the immune system interfering
>with the brain functions? 

I don't know about the possibility of it being an autoimmune disease, but
I have read a couple of papers/communications about the possibility of
Schizophrenia and Alzheimer's (in different papers) being slow acting
virus entering the brain through the olfactory receptors.

Unfortunately I don't have the paper here, and I don't remember the
author(s), but I can find out if anyone is interested.

Leslie Kay
From: kristoff@NET.BIO.NET (David Kristofferson)
Newsgroups: bionet.genome.chrom22
Subject: BIOSCI/bionet Frequently Asked Questions
Date: 10 Jan 93 10:00:03 GMT
Distribution: bionet


New users of BIOSCI/bionet may want to read the "Frequently Asked
Questions" or "FAQ" sheets for BIOSCI.  There are two FAQ sheets for
the newsgroup system.  FAQ I describes the general purpose and uses of
the BIOSCI/bionet newsgroups.  FAQ II provides details on how to
participate in these forums.  Both of these FAQs are available for
anonymous FTP from net.bio.net [134.172.2.69] in
pub/BIOSCI/biosci1.FAQ and pub/BIOSCI/biosci2.FAQ.  They may also be
requested by sending e-mail to biosci@net.bio.net (use plain English
for your request).  The FAQs are also posted on the first of each
month to the newsgroup BIONEWS/bionet.announce immediately following
the posting of the BIOSCI information sheet.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: nam@postech.ac.kr (Hong-Gil Nam)
Newsgroups: bionet.genome.arabidopsis
Subject: (none)
Date: 12 Jan 93 07:33:32 GMT
Distribution: bionet



Dear BIOSCI/bionet manager

The problem with our network system has now been fixed.
Please send us your BIOSCI Arabidopsis E-mail service from November of 1992.  
		
						Thank you

	
					Dr.Hong-Gil Nam
					POSTECH,South Korea

Our address:nam@vision.postech.ac.kr
From: eagreene@pathos (Elizabeth Ann Greene)
Newsgroups: bionet.genome.arabidopsis
Subject: postdoc position in plant molecular biology
Date: 4 Jan 1993 23:07:56 GMT
Organization: U.C. College of Natural Resources
NNTP-Posting-Host: pathos.berkeley.edu



I'm posting this job announcement for Vitaly Citovsky.  Please respond
to it via U.S. mail.  Do not use my e-mail address.  
Thank you,  Liz Greene

-----------------------------------------------------------
STATE UNIVERSITY OF NEW YORK AT STONY BROOK
DEPARTMENT OF BIOCHEMISTRY AND CELL BIOLOGY

Postdoctoral position in Plant Molecular Biology available starting Fall
1993. Specific areas of research include:

(i) nuclear targeting and transport of proteins and nucleic acids in
plant cells,
(ii) mechanisms of cell-to-cell movement of plant viruses, and 
(iii) molecular biology and biochemistry of plant intercellular
connections, the plasmodesmata.

Please send curriculum vitae and names and addresses of three references
to Dr. Vitaly Citovsky, Department of Plant Biology, University of
California, Berkeley, CA 94720 (before August 1993)
or Department of Biochemistry and Cell Biology, State University of New
York, Stony Brook, NY 11794 (starting August 1993).
From: U6525069@ucsvc.ucs.unimelb.edu.au
Newsgroups: bionet.genome.arabidopsis
Subject: clone pAt5-91.5
Date: 5 Jan 93 22:08:54 GMT
Distribution: bionet

I would like to contact someone in the Goodman lab about obtaining the
clone pAt5-91.5 near tt3. I would also be grateful for information re.
YAC clones it identifies esp. from the EW library.
Chris Cobbett
From: kristoff@NCBI.NLM.NIH.GOV (Dave Kristofferson)
Newsgroups: bionet.genome.arabidopsis
Subject: test II, please ignore
Date: 7 Jan 93 21:39:53 GMT
Distribution: bionet

please ignore.
From: Steve_Howell@QMRELAY.MAIL.CORNELL.EDU ("Steve Howell")
Newsgroups: bionet.genome.arabidopsis
Subject: New subscription
Date: 10 Jan 93 20:20:18 GMT
Distribution: bionet


                       Subject:                               Time:3:21 PM
  OFFICE MEMO          New subscription                       Date:1/10/93
I'd like to join the Arabidopsis Newsgroup.

Steve Howell
Boyce Thompson Institute
From: chualab@ROCKVAX.ROCKEFELLER.EDU
Newsgroups: bionet.genome.arabidopsis
Subject: Re: postdoc position in plant molecular biology
Date: 5 Jan 93 13:43:44 GMT
Distribution: bionet

Dear Ms. Green.
Could you please send vitaly the following message. and / or e-mail me his phonephone # to mayerR@rockvax.rockefeller.edu:

Shalom Vitaly,
I have been a PhD student in Beziman's Lab at Jerusalem. Now I'm a postdoc
at Chua Lab. There are some things that I would like to dicuss with you.
Call me when you can or send your Tel. No. so that I can call you.
Raphael Mayer (Raphy Meir)
212-327-7717
Fax:212-327-8327
E-mail MayerR@rockvax.rockefeller.edu
From: David_Stern@QMRELAY.MAIL.CORNELL.EDU ("David Stern")
Newsgroups: bionet.genome.arabidopsis
Subject: Postdoctoral positions
Date: 8 Jan 93 16:51:26 GMT
Distribution: bionet


                      Postdoctoral positions
Postdoctoral Research Associates
Boyce Thompson Institute, Cornell University
Ithaca, NY

2 postdoctoral positions are available to study the post-transcriptional
control of chloroplast gene expression, commencing in the summer or fall of
1993.  Both differential mRNA stabilities and translational control play
important roles in chloroplasts, which contain RNA-binding proteins and
ribonucleases that are involved in regulating RNA processing, RNA decay rates
and translation initiation.  In spinach, emphasis is being placed on the
purification and functional analysis of sequence and/or structure-specific
RNA-binding proteins (Molec. Cell. Biol 11:4380).  In Chlamydomonas,
transformation and genetic analyses are being used to identify translational
regulatory signals.  This is being accomplished by the creation of mutant
translation initiation codons or 5' untranslated region deletions using
chloroplast transformation, and the subsequent isolation and analysis of
second-site suppressor mutations (Sakamoto et al., PNAS in press 1/93). 
Candidates should send a brief statement of their interests, a curriculum
vitae, and names of three referees to David Stern, Boyce Thompson Institute,
Cornell University, Tower Rd., Ithaca, NY  14853; telephone 607-254-1306; fax
607-254-1242; Bitnet David_Stern@qmrelay.mail.cornell.edu.  Applications will
be accepted until the positions are filled.  Boyce Thompson is an equal
opportunity/affirmative action employer.  Women and minorities are encouraged
to apply.
From: Hanna Tuomisto <hantuo@utu.fi>
Subject: 50 hectare forest plots, and the address list
Organization: University of Turku
X-Useragent: Nuntius v1.1a2
Date: Tue, 12 Jan 93 14:51:57 GMT

Comments to selected portions of the discussion between Fangliang He and
Una Smith:

>	The paper you describe sounds like a statistical exploration of
>	the data base of all 330,000 tree stem coordinates and species
>	codes.  On the face of it that is a logical strategy, but I
>	question whether you might be missing the forest for the trees.
>	Considering that there are, by my sketchy calculations, only
>	370 stems per species represented in the plot data base, and I
>	know that the most abundant species there had no more than a few
>	thousand stems, I would not expect any spatial pattern to emerge
>	from an analysis of the full data base.  So I do not find your
>	result as stated either interesting or surprising.

I'm afraid I agree with Una here.

>	What about your topological data?  Do you find any patterns there?
>	Again, I would not expect to find any overall trends, but it would
>	be interesting if there were associations between certain species
>	or groups of species and aspects of the terrain. 
>
>	What was interesting to me in the Pasoh plot data were the apparent
>	patterns of clumping of various species of trees.  Some appeared
>	to occur mainly on slopes, some on the lower flat areas (where,
>	according to Jim, wild pigs were known to forage routinely), and
>	some on the upper areas.

This is exactly what we have found in Peruvian Amazonia with shrubs and
ferns (even in the absence of pigs), and I expect the same to be true for
trees also. The spatial patterns of individual species are certainly
worth while analyzing.

>	All we need is someone to volunteer to maintain the list [of the
persons who are interested in tropical rainforests]

I volunteer. Ten persons have already sent their addresses to me, and I
will continue to update the list as people send to me their addresses. By
the end of this week I'll mail the list to all the persons who are in it,
and after that I can send updates when enough new addresses (or
corrections to the old ones) have accumulated.

So everybody who wants to participate: please e-mail me your name,
address, e-mail address, and short description of special interests. And
let the invitation spread among the people you think may be interested.

Hanna Tuomisto
hantuo@utu.fi
Newsgroups: bionet.biology.tropical
From: hefa@ERE.UMontreal.CA (He Fangliang)
Subject: Una, Are you on the line?
Organization: Universite de Montreal
Distribution: na
Date: Mon, 11 Jan 1993 16:48:28 GMT

Hello, Una, Are you on the line? I have tried to send you a mail
once I got yours. But it seems there is something wrong with
your address. I tried several ways but all were failed. Anyway, if
you try to post something, go ahead (just correct some typing
mistakes).
Hope the system will work next time.
Greeting.

Fangliang He

Newsgroups: bionet.biology.tropical
From: sendall@dxpt01.cern.ch (Mike Sendall)
Newsgroups: bionet.biology.computational
Subject: Re: Computer models of Neoplasia
Date: 8 Jan 93 14:25:03 GMT
Distribution: bionet
Organization: CERN (European Laboratory for Particle Physics)
Originator: biocomp@lerkim.umiacs.umd.edu


In article <jr_1-050193142956@webmac4.his.path.cam.ac.uk>, jr_1@mbuk.bio.cam.ac.uk (Jem Rashbass) writes:
|>From: jr_1@mbuk.bio.cam.ac.uk (Jem Rashbass)
|>Newsgroups: bionet.biology.computational
|>Subject: Computer models of Neoplasia
|>Message-ID: <jr_1-050193142956@webmac4.his.path.cam.ac.uk>
|>Date: Tue, 5 Jan 93 14:31:46 MET
|>Organization: Dept of Histopathology, Cambridge UK
|>Approved: comp-bio-moderator@genbank.bio.net
|>
|>Does anyone know where I might a computer model of neoplastic cells?
|>
|>Many Thanks,
|>
|>Jem Rashbass,                       jr_1@mbuk.bio.cam.ac.uk,
|>Dept of Histopathology
|>Addenbrookes Hospital
|>Cambridge UK.
|>
If you get any answers, maybe you could post a summary to this newsgroup.

Thanks