From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Zebrafish retinoic acid receptor alpha 2.A (RAR-alpha-2.A) mRNA,
Date: 22 Dec 92 22:57:55 GMT
Distribution: bionet
Checksum: 18467 6

LOCUS       ZEFRARA2A    1967 bp ss-mRNA            VRT       30-NOV-1992
DEFINITION  Zebrafish retinoic acid receptor alpha 2.A (RAR-alpha-2.A) mRNA,
            complete cds.
ACCESSION   L03398
KEYWORDS    retinoic acid receptor-alpha-2-isoform;
            retinoic acid receptor-alpha-2.A-isoform.
SOURCE      Brachydanio rerio gastrula (6-9 hours post fertilization) embryo
            cDNA to mRNA.
  ORGANISM  Brachydanio rerio
            Eukaryota; Animalia; Chordata; Vertebrata; Osteichthyes;
            Actinopterygii; Cypriniformes; Cyprinoidei; Cyprinidae.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Stachel,S.E. and Kushner,P.
  TITLE     The molecular characterization of three zebrafish retinoic acid
            receptor genes suggests the retinoic acid pathway functions in
            embryonic hindbrain development
  JOURNAL   Unpublished (1993)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Stachel,S.E.
  TITLE     Retinoic acid reprograms RAR expression and shows anteroposterior
            specification occurs in the pre-gastrula zebrafish
  JOURNAL   Unpublished (1993)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mRNA            1..1967
                     /gene="zRAR-alpha-2.A"
                     /citation=[1]
                     /partial
                     /note="'zebrafish encodes 2 separate RAR alpha-2 genes'"
     misc_feature    121..258
                     /label=A-domain
                     /note="'type 2 isoform'"
     misc_feature    448..540
                     /function="'DNA binding'"
                     /label=C-domain
     misc_feature    679..1338
                     /function="'ligand binding'"
                     /label=E-domain
     CDS             121..1455
                     /gene="zRAR-alpha-2.A"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
                     /product="retinoic acid receptor alpha-2.A"
                     /codon_start=1
                     /translation="MYESVDVNPFLMMDYYNQSRGCLIPDKMPHPFSSSIRHQHWSGS
                     NHSIETQSTSSEEIVPSPPSPPPPPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRS
                     IQKNMVYTCHREKNCIINKVTRNRCQYCRLQKCLEVGMSKESVRNDRNKKKKEEKKPE
                     CTENYTLSPDTEQMIDRVRKAHQETFPSLCQLGKYTTSNSSERRVALDVDLWDKFSEL
                     STKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDG
                     LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLLCGDRQDLEQADK
                     VDVLQEPLLEALKIYVRNRRPHKPHMFPKMLMKITDLRSISAKGAELLITLKMEIPGS
                     MPPLIQEMLENSEGLESSSGAQGSRASATTPGSCSPSLSPNSAQSSPPTQSP"
BASE COUNT      557 a    489 c    467 g    454 t
ORIGIN      
        1 ctgatctccg ctgggaataa cagggatgtc tgggatggat ccatcgctct gttaaatctc
       61 tatgtgaatt ctacagtcgt ggatcagccg ttgtcttgag gaattgtgtc cgatctgatc
      121 atgtatgaga gtgtggatgt gaaccctttc ctcatgatgg attactataa tcagagcaga
      181 ggatgtctga tcccggacaa gatgccccat cccttcagct catccatcag acatcagcac
      241 tggagcggat ccaaccactc tattgagacc cagagtacga gttcagaaga gatcgtcccg
      301 agcccaccct ctccaccccc tcctcctcgc atctacaagc cctgctttgt gtgtcaggac
      361 aaatcttcag ggtaccacta tggcgtcagt gcctgtgagg gctgcaaggg tttcttcagg
      421 cgaagcattc agaagaatat ggtgtacacg tgccaccgag agaagaactg catcatcaac
      481 aaagtcaccc gcaaccgctg tcaatactgc cggctgcaga agtgcctgga agtggggatg
      541 tccaaagaat cggtgaggaa tgacagaaat aagaagaaga aagaagagaa aaagcccgaa
      601 tgcacagaga actacacgct gagcccagac acagagcaga tgatcgacag agttagaaaa
      661 gcccaccaag agaccttccc ctcgctctgt cagctcggca aatacaccac gagtaatagc
      721 tcggagcggc gtgtggccct ggatgtggat ttatgggata agtttagcga actctccaca
      781 aagtgtatca taaagacagt ggagtttgct aagcagctgc cagggttcac cacccttacc
      841 atcgcagacc agatcaccct gctgaaggcc gcctgcctcg acatactgat tctgaggatc
      901 tgcacccgct acacgcccga gcaggacacc atgacgttct ctgatggttt aacactcaac
      961 cgaacacaga tgcacaacgc aggcttcggt ccgctaacag acctggtgtt cgctttcgct
     1021 aatcagctac taccgctaga gatggatgac gctgagacgg gactgctcag tgctatatgt
     1081 ctgctgtgtg gagatcggca ggacctggaa caggctgata aggtggatgt actgcaggaa
     1141 ccccttctgg aagcactgaa gatctacgtg aggaacagaa ggccacacaa accacacatg
     1201 ttccctaaga tgctgatgaa gattactgat ctgaggagca tcagtgcaaa gggagcggag
     1261 ctgttgatca ccctgaagat ggagattccg ggctccatgc ctcctctaat ccaggagatg
     1321 ttggagaact ctgagggttt ggagagctcc tcaggcgcac agggctcacg ggcctccgcc
     1381 actactccgg gcagttgtag cccctccctc tctcccaact ccgcccagag cagcccgccc
     1441 acacagtcac cgtgacaacc atcatctaaa ccatcattag ccacttacgg actactgtgt
     1501 gctctcccga cacactcgaa aaacacactc tcagtgccga tactctgcct gtgggagaat
     1561 caaagctgtg ttaccggaat ttttattttt tttcctcaga tcagactgtg attgtattcc
     1621 tccttaattc ccaaggggga caagggtgaa gaaagaaaag aaaaaagaaa aaaaacttaa
     1681 gaatgaatga atggacaatt gtagaaggac tttcttctgc ttcgattctt ctggcctgca
     1741 atgaccagag actgattcct acaaactaaa aacacgataa tatatataga gaaaacctgg
     1801 aatgattgtg cttgcgatag aatgaaacat ggacttgatg taaaaatgca tttcctcact
     1861 ttttctctta atgcctgtga aaggacaaag agtgaattgt tttctttcag actgattatg
     1921 atgtttttca tggtgaaaaa aaaacattga aaagattatt aattttc
//