From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: R.norvegicus mRNA for epithelin 1 and 2
Date: 11 Sep 92 10:06:51 GMT
Distribution: bionet
Checksum: 63835     6

LOCUS       RATEPIT1     2153 bp ss-RNA             ROD       11-SEP-1992
DEFINITION  R.norvegicus mRNA for epithelin 1 and 2
ACCESSION   X62322
KEYWORDS    Epithelin 1; Epithelin 2; epithelial cell growth regulator;
            soluble protein.
SOURCE      Rattus norvegicus RNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Plowman,G.D.
  JOURNAL   Unpublished (1991)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Plowman,G.D., Green,J.M., Neubauer,M.G., Buckley,S.D.,
            McDonald,V.L., Todaro,G.J. and Shoyab,M.
  TITLE     The epithelin precursor encodes teo proteins with opposing
            activities on epithelial cell growth
  JOURNAL   J. Biol. Chem. 267, 13073-13078 (1992)
  STANDARD  full staff_review
COMMENT     *source: tissue=kidney; *source: clone_library=lambda gt10;
            See also X62320-2
            From EMBL    entry RNEPIT1;  dated 26-AUG-1992.
FEATURES             Location/Qualifiers
     sig_peptide     31..81
     CDS             31..1800
                     /product="Epithelin 1 & 2"
                     /codon_start=1
                     /translation="MWILVSWLALVARLVAGTQCPDGQFCPVACCLDQGGANYSCCNP
                     LLDTWPIITSRRLDGSCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRG
                     FHCSADGKSCSQISDSLLGAVQCPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDR
                     VHCCPHGASCDLVHTRCISPTGTHPLLKKFPAQRTNRAVAFPFSVVCPDAKTQCPDDS
                     TCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKDYTTDLMTKLPGYP
                     VNEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTCE
                     LGVLQVPWMKKVTASLSLPDPQILKNDVPCDDFSSCPSNNTCCRLSSGDWGCCPIPEA
                     VCCLDHQHCCPQGFKCMDEGYCQKGDRMVAGLEKMPVRQTTLLQHGDIGCDQHTSCPV
                     GQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDAGSVQPSMDLTF
                     GSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGT
                     KCLRKKTPRWDILLRDPAPRPLL"
     mat_peptide     82..1797
                     /product="Epithelin 1 & 2"
     misc_feature    142..144
                     /note="pot. glycosylation site"
     misc_feature    205..372
                     /note="cysteine motif 1"
     misc_feature    397..567
                     /note="cysteine motif 2"
     misc_feature    643..813
                     /note="Epithelin 2"
     misc_feature    868..1035
                     /note="Epithelin 1"
     misc_feature    1114..1278
                     /note="cysteine motif 5"
     misc_feature    1147..1149
                     /note="pot. glycosylation site"
     misc_feature    1348..1515
                     /note="cysteine motif 6"
     misc_feature    1573..1740
                     /note="cysteine motif 7"
     misc_feature    1606..1608
                     /note="pot. glycosylation site"
BASE COUNT      449 a    603 c    587 g    514 t
ORIGIN
        1 agggagcgcg gaccccgacg caggcagacc atgtggatcc tggtgagctg gctggcctta
       61 gtggcaaggc tggtggctgg aacacagtgc ccagatggtc aattctgccc tgttgcctgc
      121 tgccttgacc agggaggagc caactacagc tgctgtaacc ctcttctgga cacatggcct
      181 ataataacga gccgtcgtct agatggctcc tgccagatcc gtgaccactg tcctgatggc
      241 tactcttgtc ttctcactgt gtctgggact tccagctgct gcccgttctc tgagggtgta
      301 tcttgtgatg atggccagca ctgctgcccc cggggcttcc actgtagtgc ggatgggaaa
      361 tcctgctctc agatatcaga tagcctcttg ggtgctgtcc agtgtcctgg tagccagttc
      421 gaatgtcctg actccgccac ctgctgtatt atgattgatg gttcctgggg gtgctgcccc
      481 atgccccagg cctcttgctg tgaagacaga gtgcattgct gtccccacgg ggcctcctgt
      541 gacctggttc acacgcgatg catttcaccc acgggcaccc accccttact aaagaaattc
      601 cccgcacaaa ggaccaacag ggcagtggct ttcccttttt ccgtggtgtg ccctgatgct
      661 aagacccagt gccctgatga ctctacctgc tgtgagctac ccactgggaa gtatggctgt
      721 tgtccaatgc ccaacgccat ctgctgttcc gaccacctgc actgctgccc ccaggacact
      781 gtatgtgacc tgatccagag caagtgcata tccaaggact acaccacaga tctcatgacc
      841 aagctgcctg gatacccagt gaatgaggtg aagtgcgact tggaggtgag ctgtcctgat
      901 ggctacacct gctgccgcct caacactggg gcctggggct gctgtccatt caccaaggct
      961 gtgtgttgtg aagaccacat tcactgctgc ccagccgggt ttcagtgtca cacagagaca
     1021 ggaacctgtg aactgggagt ccttcaggta ccctggatga aaaaggtcac ggcctccctc
     1081 agcctgccag acccacagat cttgaagaat gatgtcccct gtgatgactt cagtagctgt
     1141 ccttctaaca atacctgctg cagactcagt tctggggact ggggctgctg tcccatccca
     1201 gaggctgtct gctgcttaga ccaccagcat tgctgccctc agggtttcaa atgtatggat
     1261 gaggggtact gtcagaaggg agacagaatg gtggctggcc tggagaagat gcctgtccgc
     1321 cagacaactc tgctccaaca tggagatatt ggttgtgacc agcataccag ctgcccagta
     1381 gggcaaacat gctgcccaag cctgaaggga agttgggcct gctgccagtt gccccatgct
     1441 gtgtgctgtg aggaccggca gcactgttgc ccggctgggt acacctgcaa cgtgaaggcg
     1501 agaacctgtg agaaggatgc aggctctgtc cagccttcca tggacctgac ctttggctct
     1561 aaggttggga atgtggaatg tggtgccgga catttctgcc atgataacca gtcctgttgt
     1621 aaagacagcc aaggaggctg ggcctgctgt ccctatgtaa agggtgtctg ctgtagagat
     1681 ggacgtcact gttgtcccat tggcttccac tgttcagcca agggaaccaa gtgtttgcgg
     1741 aagaagaccc ctcgctggga catacttttg agggatccag ccccaagacc gctactgtga
     1801 ggaagggcta acgactaaag aactccacag tcctgggaac cctgttctga gggtatccac
     1861 cactcaggcc tccctggcac ctcttccttt agtctccccg gcctactcat tctgagtcac
     1921 cccatcacca tggaaggtgg ggcctcaaac taagaccttc tcttatggaa agaaggctgt
     1981 ggcaaaagcc ccgtatcaaa ctgccatttc ttctgatttc tgtggacctt gtggccaggt
     2041 gctcttctcg atccacaggt gttgtgtgag cttgcttttg tgtgtgtgtg tgtgcgcgcg
     2101 tgcgagcgtg ttgctccaat aaagtttgta cactttcaaa aaaaaaaaaa aaa
//