From: A5161DAA@vm.univie.ac.at (Dieter Blaas)
Subject: POST DOC WANTED
Organization: University of Vienna
Date: Thu, 19 Nov 1992 09:11:13 GMT

CALL FOR POST-DOCS

                                     Vienna, 19th November, 1992.

The Institute of Biochemistry, University of Vienna has recently
moved into a new building; it is now part of the Vienna Biocenter,
which includes four other University Departments and is situated next
to the Institute of Molecular Pathology. The acute problems of lack of
space and equipment are now a thing of the past and we are enjoying
the advantages of well-designed laboratories.
We are in the process of trying to increase the international
atmosphere of the Institute by attracting Post-Docs from other
countries. As the University did not provide us with new posts for the
new building, we cannot offer anything specific. We can, however, offer
anyone interested in joining our lab our help and support in obtaining
an EMBO fellowship or a Lise Meitner Stipend (a Stipend from the
Austrian Government to enable foreign scientists to work in Austria).
The research interests of our group center on various aspects
of the interaction of picornaviruses with the host cell, in particular on
the expression, purification and characterisation of rhinoviral
proteinase mutants, the nature of viral targets involved in modifying
the translation machinery of the cell, antibody engineering of
rhinovirus neutralising antibodies (in collaboration with a
crystallography group in Barcelona), the expression of other viral
proteins and the molecular cloning of the equine rhinovirus genome.
A list of recent publications is enclosed.
    We would hope that anyone interested would have a strong
background in molecular biology or protein chemistry; if desired, the
project could be arranged to allow the post-doc to gain experience in
a particular area.

Contact: Prof. Dr. Ernst Kuechler, or Dr. Tim Skern, or Dr. Dieter Blaas
Institut fuer Biochemie der  Medizinischen Fakultaet
der Universitaet Wien
DR. BOHR-GASSE 9,  3. STOCK, A-1030 WIEN, AUSTRIA
TEL. : (+43) -1/79 515-3125    FAX: (+43)-1/79 515-3114
E-MAIL :  A5161DAA@VM.UNIVIE.AC.AT

Literature:

Gruenberger, M., Pevear, D., Diana, G.D., Kuechler, E., and Blaas,
D. (1991). Stabilization of human rhinovirus serotype 2 against
pH induced conformational change by antiviral compounds. J.
Gen. Virol. 72, 431-433.

Skern, T., Sommergruber, W., Auer, H., Volkmann, P., Zorn, M.,
Liebig, H-D., Fessl, F., Blaas, D., and Kuechler, E. (1991).
Substrate requirements of a human rhinovirus 2A proteinase.
Virology 181, 46-54.

Skern. T., Torgersen, H., Auer, H., Kuechler, E., and Blaas, D.
(1991). Human rhinovirus mutants stable at low pH. Virology 183,
757-763.


Liebig, H-D, Skern, T., Luderer, M., Sommergruber, W., Blaas, D.,
and Kuechler, E. (1991). Proteinase trapping: Screening for viral
proteinase mutants using  *-complementation. Proc. Natl. Acad.
Sci. U.S.A. 88, 5979 - 5983.

Hofer, F., Berger, B., Gruenberger, M., Machat, H., Dernick, R.,
Kuechler, E., and Blaas, D. (1992). Shedding of a rhinovirus
minor group binding protein: Evidence for a Ca++-dependent
process. J. Gen. Virol.73, 627 - 632.

Tormo, J., Stadler, E., Skern, T., Auer, H., Kanzler, O., Betzel, C.,
Blaas, D., and Fita, I. (1992). Three dimensional structure of the
Fab fragment of a neutralizing antibody to human rhinovirus
serotype 2. Protein Science 1, 1154 - 1161.

Sommergruber, W., Ahorn, H., Zophel, A., Maurer-Fogy, I., Fessl, F.,
Schnorrenberg, G., Liebig, H-D., Blaas, D., Kuechler, E., and
Skern, T. (1992). Cleavage Specificity on Synthetic Peptide
Substrates of Human Rhinovirus 2 Proteinase 2A. J. Biol. Chem.
(in press).