From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens cyclooxygenase-2 (Cox-2) mRNA, complete cds.
Date: 22 Aug 92 10:00:55 GMT
Distribution: bionet
Checksum: 15527     7

LOCUS       HUMCYCLOX    3387 bp ss-mRNA            PRI       22-AUG-1992
DEFINITION  Homo sapiens cyclooxygenase-2 (Cox-2) mRNA, complete cds.
ACCESSION   M90100
KEYWORDS    cyclooxygenase-2; prostaglandin synthase.
SOURCE      Homo sapiens umbilical vein cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Hla,T. and Neilson,K.
  TITLE     Human cyclooxygenase-2 cDNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 7384-7388 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     5'UTR           1..97
                     /gene="Cox-2"
     CDS             98..1912
                     /EC_number="1.14.99.1"
                     /product="cyclooxygenase-2"
                     /gene="Cox-2"
                     /codon_start=1
                     /translation="MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDC
                     TRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYV
                     LTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDS
                     NEIVGKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNH
                     IYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE
                     VFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDY
                     VQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQ
                     FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFN
                     EYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETM
                     VEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSF
                     SVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL"
     sig_peptide     98..148
                     /gene="Cox-2"
                     /codon_start=1
     mat_peptide     149..1909
                     /EC_number="1.14.99.1"
                     /product="cyclooxygenase-2"
                     /gene="Cox-2"
                     /codon_start=1
     3'UTR           1913..3387
                     /gene="Cox-2"
     polyA_signal    3369..3374
                     /gene="Cox-2"
BASE COUNT     1010 a    712 c    633 g   1032 t
ORIGIN
        1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca
       61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct
      121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa
      181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg
      241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa
      301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt
      361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca
      421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt
      481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc
      541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct
      601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc
      661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa
      721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg
      781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta
      841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca
      901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc
      961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga
     1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa
     1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga
     1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa
     1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata
     1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt
     1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc
     1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc
     1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac
     1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga
     1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat
     1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc
     1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc
     1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt
     1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact
     1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa
     1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt
     1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg
     2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc
     2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga
     2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac
     2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat
     2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta
     2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga
     2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt
     2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa
     2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt
     2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata
     2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg
     2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat
     2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc
     2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt
     2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat
     2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat
     3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc
     3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg
     3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct
     3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta
     3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct
     3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc
     3361 ttaagaagat taaaaaaaaa aaaaaag
//