From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human 26S protease (S4) regulatory subunit mRNA, complete cds.
Date: 6 Jan 93 06:49:18 GMT
Distribution: bionet
Checksum: 00338 4

LOCUS       HUM26SPSIV   1599 bp ss-mRNA            PRI       05-JAN-1993
DEFINITION  Human 26S protease (S4) regulatory subunit mRNA, complete cds.
ACCESSION   L02426
KEYWORDS    26S protease (S4) regulatory subunit; ATP-dependent protease;
            ATPase; ubiquitin-dependent protease.
SOURCE      Homo sapiens (library: Lambda Zap II) cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Dubiel,W., Ferrell,K., Pratt,G. and Rechsteiner,M.C.
  TITLE     Subunit 4 of the 26S protease is a member of a novel eukaryotic
            ATPase family
  JOURNAL   J. Biol. Chem. 267, 22699-22702 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     RBS             55..64
     polyA_signal    1577..1582
     CDS             61..1383
                     /function="degradation of ubiquitinated proteins"
                     /evidence="EXPERIMENTAL"
                     /product="26S protease (S4) regulatory subunit"
                     /codon_start=1
                     /translation="MGQSQSGGHGPGGGKKDDEDKKKKYEPPVPTRVGKKKKKRKGPD
                     AASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDL
                     RGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVI
                     GVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKP
                     PKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEE
                     HAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRI
                     ETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSG
                     ADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL"
BASE COUNT      489 a    321 c    424 g    365 t
ORIGIN      
        1 aattccggcg gaagtggtgg aggaacttcc ggcagcggca gctcaagtgg ccaaggcaag
       61 atgggtcaaa gtcagagtgg tggtcatggt cctggaggtg gcaagaagga tgacgaggac
      121 aagaaaaaga aatatgaacc tcctgtacca actagagtgg ggaaaaagaa gaagaaaaga
      181 aagggaccag atgctgccag caaactgcca ctggtgacac ctcacactca gtgccggtta
      241 aaattactga agttagagag aattaaagac tatcttctca tggaggaaga attcattaga
      301 aatcaggaac aaatgaaacc attagaagaa aagcaagagg aggaaagatc aaaagtggat
      361 gatctgaggg ggaccccgat gtcagtagga accttggaag agattattga tgacaatcat
      421 gccatcgtgt ctacatctgt gggctcagaa cactacgtca gcattctttc atttgtagac
      481 aaggatctgc tggaacctgg ctgctcggtc ctgctcaacc acaaggtgca tgccgtgata
      541 ggggtgctga tggatgacac ggatcccctg gtcacagtga tgaaggtaga aaaggccccc
      601 caggagacct atgcagatat tggggggttg gacaaccaaa ttcaggaaat taaggaatct
      661 gtggagcttc ctctcaccca tcctgaatat tatgaagaga tgggtataaa gcctcctaag
      721 ggggtcattc tctatggtcc acctggcaca ggtaaaacct tgttagccaa agcagtagca
      781 aaccaaacct cagccacttt cttgagagtg gttggctctg aacttattca gaagtaccta
      841 ggtgatgggc ccaaactcgt acgggaattg ttccgagttg ctgaagaaca tgcaccgtcc
      901 atcgtgttta ttgatgaaat tgacgccatt gggacaaaaa gatatgactc caattctggt
      961 ggtgagagag aaattcagcg aacaatgttg gaactgctga accagttgga tggatttgat
     1021 tctaggggag atgtgaaagt tatcatggcc acaaaccgaa tagaaacttt ggatccagca
     1081 cttatcagac caggccgcat tgacaggaag attgagttcc ccctgcctga tgaaaagacg
     1141 aagaagcgca tctttcagat tcacacaagc aggatgacgc tggctgatga tgtaaccctg
     1201 gacgacctga tcatggctaa agatgacctc tctggtgctg acatcaaggc aatctgtaca
     1261 gaagctggtc tgatggcctt aagagaacgt agaatgaaag taacaaatga agacttcaaa
     1321 aaatctaaag aaaatgttct ttataagaaa caggaaggca cccctgaggg gctgtatctc
     1381 taatgaacca tggctgtcat caggaaaatg gttgggagat ttctcaatcc ctgaaaggga
     1441 tgaggttggg ggagttgccc agaggaatcc ctgttcccac tgatttttat tagcaaaaca
     1501 tcctgtgtct tttggagtac gatgtgtaag tgcccattgg gtggcctgtt ggtcactgtg
     1561 cagcagtctg cttcccaata aagcgtgctc tttcacaag
//