From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human glucose transporter (GLUT4) gene, complete cds.
Date: 11 Sep 92 10:04:29 GMT
Distribution: bionet
Checksum: 14065    16

LOCUS       HUMGLUT4B    8402 bp ds-DNA             PRI       11-SEP-1992
DEFINITION  Human glucose transporter (GLUT4) gene, complete cds.
ACCESSION   M91463
KEYWORDS    Alu repetitive element; glucose transporter.
SOURCE      Homo sapiens Fetal Liver DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 8402)
  AUTHORS   Buse,J.B., Yasuda,K., Lay,T.P., Seo,T.S., Liu,M.L., Olson,A.L.,
            Pessin,J.E., Moye-Rowley,W.S., Karam,J.H., Seino,S. and Bell,G.I.
  TITLE     Expression and regulation of the human GLUT4/muscle-fat
            facilitative glucose transporter gene in transgenic mice
  JOURNAL   J. Biol. Chem. 267, 11673-11676 (1992)
  STANDARD  full staff_entry
REFERENCE   2  (sites)
  AUTHORS   Liu,M.-L., Olson,A.L., Moye-Rowley,W.S., Buse,J.B., Bell,G.I. and
            Pessin,J.E.
  TITLE     Expression and regulation of human GLUT4/muscle-fat facilitative
            glucose transporter gene in transgenic mice
  JOURNAL   J. Biol. Chem. 267, 11673-11676 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             join(2225..2257,3535..3651,3763..3935,4028..4152,
                     4276..4379,4507..4669,4775..4962,5125..5229,5378..5479,
                     5995..6198,6716..6919)
                     /product="glucose transporter"
                     /gene="GLUT4"
                     /codon_start=1
                     /translation="MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGV
                     INAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGII
                     SQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLVPMYVGEIA
                     PTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPF
                     CPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLG
                     SRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTL
                     VSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFE
                     IGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFA
                     VLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND"
     mRNA            join(2033..2257,3535..3651,3763..3935,4028..4152,
                     4276..4379,4507..4669,4775..4962,5125..5229,5378..5479,
                     5995..6198,6716..8402)
                     /product="glucose transporter"
                     /gene="GLUT4"
     repeat_region   6..308
                     /rpt_family="Alu repeat 1"
     exon            2033..2257
                     /number=1
                     /gene="GLUT4"
                     /label=exon_1
     intron          2258..3534
                     /number=1
                     /gene="GLUT4"
     exon            3535..3651
                     /number=2
                     /gene="GLUT4"
     intron          3652..3762
                     /number=2
                     /gene="GLUT4"
     exon            3763..3935
                     /number=3
                     /gene="GLUT4"
     intron          3936..4027
                     /number=3
                     /gene="GLUT4"
                     /label=exon_1
     exon            4028..4152
                     /number=4a
                     /gene="GLUT4"
     intron          4153..4275
                     /note="intron 4a"
                     /gene="GLUT4"
     exon            4276..4379
                     /number=4b
                     /gene="GLUT4"
     intron          4380..4506
                     /note="intron 4b"
                     /gene="GLUT4"
     exon            4507..4669
                     /number=5
                     /gene="GLUT4"
     intron          4670..4774
                     /number=5
                     /gene="GLUT4"
     exon            4775..4962
                     /number=6
                     /gene="GLUT4"
     intron          4963..5124
                     /number=6
                     /gene="GLUT4"
     exon            5125..5229
                     /number=7
                     /gene="GLUT4"
     intron          5230..5377
                     /number=7
                     /gene="GLUT4"
     exon            5378..5479
                     /number=8
                     /gene="GLUT4"
     intron          5480..5994
                     /number=8
                     /gene="GLUT4"
     exon            5995..6198
                     /number=9
                     /gene="GLUT4"
     intron          6199..6715
                     /number=9
                     /gene="GLUT4"
     exon            6716..8402
                     /number=10
                     /gene="GLUT4"
     repeat_region   7407..7725
                     /rpt_family="Alu repeat 2"
BASE COUNT     1655 a   2461 c   2411 g   1875 t
ORIGIN
        1 gaattccgga tttttttttt tcttcttgag acggagtcac tctgtcgcca ggctggagtg
       61 caagggcacg atcttggctc actacaacct ccacctcctg ggttcaagcc attttcctgc
      121 ctcagcctcc cgagtagctg ggattacagg tgtgcataac cacgcccggc taatttttgt
      181 atctttagca gacatggggt ttctctatgt tggccaggct ggtttcaaac tcctgacctc
      241 agtcgatcca cctgccttgg cctcctaaag tgctgggatt acaggcatga gccaccaggc
      301 cgggccggca ttccagattt ttcaggggat tcgtgcagca aaggaatcaa gaagggatgt
      361 aaaggcacag tgtgttctgg gtacaataag gacttaggca ttgcccagaa caggaggcga
      421 aggagataga aggagaggca ggagagatag gtaaggccag agatcggata agagaggcag
      481 gaggttttgt tcactctgaa aagggatttg aacttggcaa ttggggcaac agagacagtg
      541 acttcttgct tgagagatga gattggacct tcgaaaattg ttctctgccc tcgtcataaa
      601 ggaaataaga ggagcacgaa gaccagtgag ggtgatggtg atctggactg aagtggcagc
      661 cgccacggag aatatcggat gaatgtgaga gagttttgga ggtcaaagca ccaatgttgg
      721 aaactaactg gataaacgag gagagcggcg caggacagga ggaatcgagc ctgacttcta
      781 ccataggggt gactgggcgg gtaattcatt gaaataagga agttaggagg aggagcaggt
      841 ttggacatgc tgatcactag agctgccaca tccgggcggt aacgaacacc tggatctgca
      901 gctccagaga agggcctggg tcagatgtca ctgaagccct atggtggcgg aaaggcgaga
      961 aatagtgggt tgagattcca agtgcaatcc actgcggctc ctcgctcgcc ctccaggtgg
     1021 cagcacaacc ctgcgcttcc gaagcccgtt ttctgagcca gacactctcc acgctctggg
     1081 tatttcggct tctctctccc cacacgccga ccctaggtcg cgcactttct gcctggcaga
     1141 atttggccga gggatccaaa cccggagcag cctccagaga gcgtgtcgtt cacgcggcca
     1201 gcatatgctc agagacctca gaggctcaga gacctcaggg ctggtggtgt ggtcggttgt
     1261 gaccacttgt ccctcggacc ggctccagga accaacctgg ggaatgtgtg taggggaagg
     1321 gcgggataga cagtgcccgg agcagggagg cgctgaaaga caggaccaag cagcccggcc
     1381 accagacccg ttgtgggaac ggaatttcct ggcccccagg gccacactcg cgtgggaagc
     1441 atgtcgcgga ccctttaagg cgtcatctcc ctgtctctcc gcccccgcct gggacaggcc
     1501 gggacgcccg ggacctgaca tttggaggct cccaacgtgg gagctaaaaa tagcagcccc
     1561 gggttacttt ggggcattgc tcctctccca acccgcgcgc cggctcgcga gccgtctcag
     1621 gccgctggag tttccccggg gcaagtacac ctggcccgtc ctctcctctc agaccccact
     1681 gtccagaccc gcagagttta agatgcttct gcagcccggg atcctagctg gtgggcggag
     1741 tcctaacacg tgggtgggcg gggccttttg ttccagggac tcttttctca aaacttccca
     1801 gtcggaggct ggcgggaacc cgagaggcgt gtctcgccag ccacgcggag gggcgtggcc
     1861 tcattggccc gccccaccaa ctccagccaa actctaaacc ccaggcggag ggggcgtggc
     1921 cttctggggt gtgcgggctc ctggccaatg ggtgctgtga agggcgtggc ccgcgggggc
     1981 aggagcgagg tggcgggggc ttctcgcgtc ttttccccca gccccgctcc acaagatccg
     2041 cgggagcccc actgctctcc ggatccttgg cttgtggctg tgggtcccat cgggcccgcc
     2101 ctcgcacgtc actccgggac ccccgcggcc tccgcaggtt ctgcgctcca ggccggagtc
     2161 agagactcca ggatcggttc tttcatcttc gccgcccctg cgcgtccagc tcttctaaga
     2221 cgagatgccg tcgggcttcc aacagatagg ctccgaagta ggattcatca tgagggggcg
     2281 gggcgggggg gcacgggtcc cgcttttctt gggctggggt cgcggttggg gtcagctggg
     2341 ggtggttcct gcgcaggcgc agggggtgaa ggtagggggc tggctattta tacccggcct
     2401 ggacaacccg tgactgtgag attccaatcc taccaaaagg cagagtgggt ctggagggcc
     2461 tttcggggca caggcagcaa gtggattctg cgagccaggg ttcaccccct tgcctagtag
     2521 gcggcgcggc gctccggaat cggggacacc ctgccctcga tccgactcgg gaaagcagat
     2581 ccaggcgggt cttgccctcc gggagctgtc cgtccgtctt cgctcacggg cagtgtttcg
     2641 aggaccggag gctctccgtg ggcccccacc cccactcctg gccgccctcc aggacgctga
     2701 actttccctt ggccccatgg ttggtggagg ggcagagggg actgtcagcc ccccctcccc
     2761 cagctcaggt ttccgcttgg agacagtctg tgccgccagc gagcggccac cactgccacc
     2821 gcccctcaca ccaccttcct gccctcctcc cctgggcatg gctctcccag gcagaacccc
     2881 tggacggccc tccctgcacg gaggttagag ggggagggca ggccacgacg tagatagaga
     2941 aggccacccc tagatgaccg ggatgtcctt tctggaacag cacttcttgg tcctgttggg
     3001 ggcctcctgg agctggctga cagaaccccc agaggggagg gaagaggaca gtggctgatg
     3061 ataataatgc acgtgttaat ttatgaaacc agcactgtca aggatattgt taacatgtga
     3121 tgttgatttt cacaacactc tcacagatag gtaggcaagg caggcaacat cacccccatc
     3181 tcacagagga cactcaggtt cggggcaggg aagtgacttg gccaaggtca cacaaatctg
     3241 agctcttaag gccaagcctg tctcaaggtc acagaagaat tttgagacaa gttctcaaac
     3301 atttctctgc cttatggacc caaacatcca gtttctcctt tatgcccagg ttgcagttca
     3361 gctcctgttt acattgagat ctttgtgcaa ttcctaatat ggcccagttt ccctcaccca
     3421 acatgttggg tggagcccag tatcttcagg ctccagctgg gcccgggccc ctagcggaag
     3481 gaaaaaaatc atggttccat gtgacatgct gtgtctttgt gtctgcctgt tcaggatggg
     3541 gaaccccctc agcagcgagt gactgggacc ctggtccttg ctgtgttctc tgcggtgctt
     3601 ggctccctgc agtttgggta caacattggg gtcatcaatg cccctcagaa ggtgagggcc
     3661 tgcagctggc agggtggggg tacccaaacg aggaggacag gtgtctcggg ggtggtggaa
     3721 aggggacggt ctgcaggaaa tctgtcctct gctgtccccc aggtgattga acagagctac
     3781 aatgagacgt ggctggggag gcaggggcct gagggaccca gctccatccc tccaggcacc
     3841 ctcaccaccc tctgggccct ctccgtggcc atcttttccg tgggcggcat gatttcctcc
     3901 ttcctcattg gtatcatctc tcagtggctt ggaaggttcg cagctggagg gcaggggtgg
     3961 gggaaacagg aagggagcca ctgctgggtg ccctcaccct cacagcctca ctctgtctgc
     4021 ctgccaggaa aagggccatg ctggtcaaca atgtcctggc ggtgctgggg ggcagcctca
     4081 tgggcctggc caacgctgct gcctcctatg aaatgctcat ccttggacga ttcctcattg
     4141 gcgcctactc aggtactcac gggcaccaca gccctgccta gcgccctgtt ctctttcacc
     4201 atgcctgggc tttcagatgg gaatggacac ctgccctcag ccctctcttc ttccctcgcc
     4261 cagggctgac atcagggctg gtgcccatgt acgtggggga gattgctccc actcacctgc
     4321 ggggcgccct ggggacgctc aaccaactgg ccattgttat cggcattctg atcgcccagg
     4381 tgaccggagc aagcctcatg ggtgcctggg cagtggttag agtggggctc tggagaatat
     4441 ggtgggcttc caaggtaagg cagaagggct gagtgacctg ccttctttcc caaccttctc
     4501 ccacaggtgc tgggcttgga gtccctcctg ggcactgcca gcctgtggcc actgctcctg
     4561 ggcctcacag tgctacctgc cctcctgcag ctggtcctgc tgcccttctg tcccgagagc
     4621 ccccgctacc tctacatcat ccagaatctc gaggggcctg ccagaaagag taagctctcc
     4681 cgctgcagcc tggcccaggc ccatgcctcc gcctcatctt gctagcacct ggcttcctct
     4741 caggtcccct caggcctgac cttcccttct ccaggtctga agcgcctgac aggctgggcc
     4801 gatgtttctg gagtgctggc tgagctgaag gatgagaagc ggaagctgga gcgtgagcgg
     4861 ccactgtccc tgctccagct cctgggcagc cgtacccacc ggcagcccct gatcattgcg
     4921 gtcgtgctgc agctgagcca gcagctctct ggcatcaatg ctgtatgtgt ggagcagcct
     4981 ccaggcaggg cacagccccg ggagggtaga cgagagtggg gagcaaaccc cctccaccaa
     5041 cacccagggt agggccagcc tgttgtggct ggagtagagg aaggggcatt cctgccatca
     5101 cttcttcttc tcccccacct ctaggttttc tattattcga ccagcatctt cgagacagca
     5161 ggggtaggcc agcctgccta tgccaccata ggagctggtg tggtcaacac agtcttcacc
     5221 ttggtctcgg taactgctca cctctggaat ggcccgagcc actggcttca cctccctggg
     5281 tgtcccggag gtcctgctct tggttgccct cacccacgcg gcccctccta cttcccgtgc
     5341 ccaaaaggct ggggtcaagc tccgactctc cccgcaggtg ttgttggtgg agcgggcggg
     5401 gcgccggacg ctccatctcc tgggcctggc gggcatgtgt ggctgtgcca tcctgatgac
     5461 tgtggctctg ctcctgctgg taaggcctgg aggctaggag gggctagcag cccaccccat
     5521 gggaatggtc ctgtgagtct ctgtgaccag ccagggtccc ttcttaacac acatgctttc
     5581 aatcctggcg ccagctccgg accaggactg gggctgactg gctccagaat ctgctgggat
     5641 tgtggtctgc tcctgaggga tttgggctgc actgggaggc agctgtggca caactctggc
     5701 agccaggagg gagagcccct gtcaagcctc aggaacaatc attcctaagg acccagcttt
     5761 agagtccagg gagagctgac cgtcataaga actgagaggc cataacattt cctctgcctt
     5821 gaacccactt gggatagcca gcagaatgcc agtcaagggc ctgctctaac ccgggacagc
     5881 aggcccccta caagctgctg cggagggggt taggtttcac ttctctgagt tgagggcaag
     5941 ggaagatcag aaaggcctca actggattct ccaccctccc tgtctggccc ctaggagcga
     6001 gttccagcca tgagctacgt ctccattgtg gccatctttg gcttcgtggc attttttgag
     6061 attggccctg gccccattcc ttggttcatc gtggccgagc tcttcagcca gggaccccgc
     6121 ccggcagcca tggctgtggc tggtttctcc aactggacga gcaacttcat cattggcatg
     6181 ggtttccagt atgttgcggt aggtcccccc gccccagcct cccacaccgt aggccagagg
     6241 tgggcatcac acagctagcc cacctgcttc cccgtcaggg actcctccag ccacagacca
     6301 tgggtctttg ggtcagtttg gtggaccacc tgctccacag aatcaaagca aggaagggag
     6361 ctgacctaga ttggatagta actgaggtgt ctgaaacgca ccagtggcat aacttacctt
     6421 actccaagaa taaaatgata cactttgcat taatactaca aacagctggg actctcctct
     6481 gagtgcagta actgaggatg gtgaagaggg cgaaaactaa gagtgtttgg ggttcagaga
     6541 atcctctttt cagtgtaaat tctcattcct gctcatttcc cttgtccctg gaggaggcag
     6601 ctgctgtctg ccgtcccccc agctccctat gaaggccttt agctcctggt tgcctgaaac
     6661 taccccttcc ctccccacct cactccgtca acacctcttt ctccacctgt cccaggaggc
     6721 tatggggccc tacgtcttcc ttctatttgc ggtcctcctg ctgggcttct tcatcttcac
     6781 cttcttaaga gtacctgaaa ctcgaggccg gacgtttgac cagatctcag ctgccttcca
     6841 ccggacaccc tctcttttag agcaggaggt gaaacccagc acagaacttg agtatttagg
     6901 gccagatgag aacgactgag gggccaggca ggggtgggag agccagctct ctctacccgg
     6961 cccagagacc ccttcctttc ctctgcagca ctttaaccct ctcttcccta ttatttccgg
     7021 gtggaaaaga atccctgcag cctggtagaa ttgggaagct gggggaaggg tggtctgagc
     7081 accccctcat tcccctcgtg tgactctctt ggattattta tgtgttgtgg tttggccgtg
     7141 gccatcaggg tgggccactc tcccctccct cttccttccc ccatcccctt tcctccccac
     7201 cttccccaga ctcagctcca gaataccttc ttcgctgcta gagaaggggg attggaggga
     7261 agacaggtct agactttctc agtgggacaa accagagcag agagcaggac aggagacaag
     7321 aaatccagtt tcccaccacc ttggactcct cccacaatct gggactttca ctgaattctt
     7381 gccacgcaga ctctgggcaa agggggttct cttttttttt tttttttttt ttttgagaca
     7441 gtctcgctct gtcgcccagg ctcgagtgca gtggcgtgat cttgcttcac tgcaagctgt
     7501 ctcccaggtt cacgccattc tcctgcctca gcctccggag tagctgggac tacaggcgca
     7561 tgccaccaca cctggctaat ttattttgta tttttagtat atacgcggtt tcaccatgtt
     7621 agccagaatg gtctcgatct cctgacctcg tgatctgcct gcctcagcct cccaaagtgc
     7681 tgggattaca ggcgtgagcc accgcgcctg gcgaagggag ttctctcttc gacccctgca
     7741 ggctcagcct tccagggcaa gagggaacag gaaagtatgt gcccatgtgt ggcaagatgg
     7801 aaggacggca ggctcccgcc tctaggcttg gggctctacc ccgatggttt cccaaggctg
     7861 ccaagaagga gccctaactt tcttcctctc ccttcctgga agggtgctgc atccacaggc
     7921 ttttgaccaa ctaaggcaaa gaggggattt gaaaggctgc ctggaaacac tgggctggga
     7981 ggagcctttg gatattttta tatacgtttg aaaaggggat tgagagaaga aaccaaaggt
     8041 cggttgtact aaatgtatat atatagatac ttctataaag tcactgctga agacaagcat
     8101 cctattgtgg aggtacttga ggatgggctg agacagggac cataactctt cacccctctt
     8161 cctccctctg tcctgcctca gctcaaggcc tcagaatctt ctggatgcca ttgctcatgc
     8221 ccctactcac atttctactc gttgctttat taatagtaaa tgctcaataa attgtagctg
     8281 ccagtgccgg gcattgctct tggcatttgc agaatactca ctctgtgagg gaggtgtcag
     8341 cccatgtcac agatgggcag tgaaacccat gataggggca ctcttcacca gggacacagc
     8401 tg
//