From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human transforming growth factor-beta type III receptor (TGF-beta)
Date: 29 Dec 92 01:28:16 GMT
Distribution: bionet
Checksum: 22765 10

LOCUS       HUMTGFB3C    4522 bp ss-mRNA            PRI       08-DEC-1992
DEFINITION  Human transforming growth factor-beta type III receptor (TGF-beta)
            mRNA, complete cds.
ACCESSION   L07594
KEYWORDS    betaglycan; endoglin; proteoglycan;
            transforming growth factor-beta type III receptor;
            transmembrane protein.
SOURCE      Homo sapiens (library: ZAPII) placenta cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Lopez-Casillas,F., Cheifetz,S., Doody,J., Andres,J.L., Lane,W.S.
            and Massague,J.
  TITLE     Structure and expression of the membrance proteoglycan betaglycan,
            a component of the TGF-beta receptor system
  JOURNAL   Cell 67, 785-795 (1991)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Wang,X.-F., Lin,H.Y., Ng-Eaton,E., Downward,J., Lodish,H.F. and
            Weinberg,R.A.
  TITLE     Expression cloning and characterization of the TGF-beta type III
            receptor
  JOURNAL   Cell 67, 797-805 (1991)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 4522)
  AUTHORS   Moren,A., Ichijo,H. and Miyazono,K.
  TITLE     Molecular cloning and the characterization of the human and porcine
            transforming growth factor-beta type III receptors
  JOURNAL   Biochem. Biophys. Res. Commun. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     sig_peptide     637..684
                     /gene="TGFB type III receptor"
                     /codon_start=1
     misc_binding    2215..2220
                     /bound_moiety="glycosaminoglycan"
                     /gene="TGFB type III receptor"
                     /note="putative"
     misc_binding    2248..2253
                     /bound_moiety="glycosaminoglycan"
                     /gene="TGFB type III receptor"
                     /note="putative"
     CDS             622..3171
                     /gene="TGFB type III receptor"
                     /product="transforming growth factor-beta type III
                     receptor"
                     /codon_start=1
                     /translation="MTSHYVIAIFALMSFCLATAGPEPGALCELSPVSASHPVQALME
                     SFTVLSGCASRGTTGLPQEVHVLNLALRQGPGQLQREVTLHLNPISSVHIHHKSVVFL
                     LNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLL
                     NWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAE
                     GCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKK
                     SVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNG
                     YSPITSYTMAPVAIVFHLRLENNEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGG
                     EGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIAL
                     SVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPR
                     WSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIV
                     VFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVT
                     KAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMD
                     KKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMM
                     QNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGAL
                     LTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA"
BASE COUNT     1229 a   1086 c   1047 g   1160 t
ORIGIN      
        1 gcggacgcga tcgcaacctc cgcttcccgg gttcaaggga ttctcctgcc tcagcctcct
       61 gagtagctgg gactacaggc gcaccactac acccggccaa tttttgtatt tatttatttt
      121 attttatttt attttttagt agagacgggg tttaccatgt tggccagaac agtctcgatc
      181 tcctaacctc gtgatccaac gcctcggctc ccaaagtgtt gagttacagg cgtgagccac
      241 cgcgcccgtc cagaattatc tttaaaattt atttctttaa gatttgtagc tactaagaaa
      301 gaaaggagct ttttttcctt gggccttcaa actgaaagaa ccgcatgagc ctgacggcgc
      361 atggtcttaa catcaggctg tgcaggaaga agctatctgc agatggatgc cagcacacac
      421 aaggaagcag agctctggca acattgagtc aaagcaagga cacaacatca gagggacggc
      481 agagaatcct tgtgtgtagt ctttggtggc agtttgaaaa ttgcaaggag ggactttaag
      541 actacttctg atttgcaaag atggtctgtg ctccgagcag gctaaagtga ctggacgaga
      601 cgcactgttg gagaaataaa aatgacttcc cattatgtga ttgccatctt tgccctgatg
      661 agcttctgtt tagccactgc aggtccagag cctggtgcac tgtgtgaact gtcacctgtc
      721 agtgcctccc atcctgtcca ggccttgatg gagagcttca ctgttttgtc aggctgtgcc
      781 agcagaggca caactgggct gccacaggag gtgcatgtcc tgaatctcgc actgcgccag
      841 gggcctggcc agctacagag agaggtcaca cttcacctga atcccatctc ctcagtccac
      901 atccaccaca agtctgttgt gttcctgctc aactccccac accccctggt gtggcatctg
      961 aagacagaga gacttgccac tggggtctcc agactgtttt tggtgtctga gggttctgtg
     1021 gtccagtttt catcagcaaa cttctccttg acagcagaaa cagaagaaag gaacttcccc
     1081 catggaaatg aacatctgtt aaattgggcc cgaaaagagt atggagcagt tacttcattc
     1141 accgaactca agatagcaag aaacatttat attaaagtgg gggaagatca agtgttccct
     1201 ccaaagtgca acatagggaa gaattttctc tcactcaatt accttgctga gtaccttcaa
     1261 cccaaagcag cagaagggtg tgtgatgtcc agccagcccc agaatgagga agtacacatc
     1321 atcgagctaa tcacccccaa ctctaacccc tacagtgctt tccaggtgga tataacaatt
     1381 gatataagac cttctcaaga ggatcttgaa gtggtcaaaa atctcatcct gatcttgaag
     1441 tgcaaaaagt ctgtcaactg ggtgatcaaa tcttttgatg ttaagggaag cctgaaaatt
     1501 attgctccta acagtattgg ctttggaaaa gagagtgaaa gatctatgac aatgaccaaa
     1561 tcaataagag atgacattcc ttcaacccaa gggaatctgg tgaagtgggc tttggacaat
     1621 ggctatagtc caataacttc atacacaatg gctcctgtgg caatagtatt tcatcttcgg
     1681 cttgaaaata atgaggagat gggagatgag gaagtccaca ctattcctcc tgagctacgg
     1741 atcctgctgg accctggtgc cctgcctgcc ctgcagaacc cgcccatccg gggaggggaa
     1801 ggccaaaatg gaggccttcc gtttcctttc ccagatattt ccaggagagt ctggaatgaa
     1861 gagggagaag atgggctccc tcggccaaag gaccctgtca ttcccagcat acaactgttt
     1921 cctggtctca gagagccaga agaggtgcaa gggagcgtgg atattgccct gtctgtcaaa
     1981 tgtgacaatg agaagatgat cgtggctgta gaaaaagatt cttttcaggc cagtggctac
     2041 tcggggatgg acgtcaccct gttggatcct acctgcaagg ccaagatgaa tggcacacac
     2101 tttgttttgg agtctcctct gaatggctgc ggtactcggc cccggtggtc agcccttgat
     2161 ggtgtggtct actataactc cattgtgata caggttccag cccttgggga cagtagtggt
     2221 tggccagatg gttatgaaga tctggagtca ggtgataatg gatttccggg agatatggat
     2281 gaaggagatg cttccctgtt cacccgacct gaaatcgtgg tgtttaattg cagccttcag
     2341 caggtgagga accccagcag cttccaggaa cagccccacg gaaacatcac cttcaacatg
     2401 gagctataca acactgacct ctttttggtg ccctcccagg gcgtcttctc tgtgccagag
     2461 aatggacacg tttatgttga ggtatctgtt actaaggctg aacaagaact gggatttgcc
     2521 atccaaacgt gctttatctc tccatattcg aaccctgata ggatgtctca ttacaccatt
     2581 attgagaata tttgtcctaa agatgaatct gtgaaattct acagtcccaa gagagtgcac
     2641 ttccctatcc cgcaagctga catggataag aagcgattca gctttgtctt caagcctgtc
     2701 ttcaacacct cactgctctt tctacagtgt gagctgacgc tgtgtacgaa gatggagaag
     2761 cacccccaga agttgcctaa gtgtgtgcct cctgacgaag cctgcacctc gctggacgcc
     2821 tcgataatct gggccatgat gcagaataag aagacgttca ccaagcccct tgctgtgatc
     2881 caccatgaag cagaatctaa agaaaaaggt ccaagcatga aggaaccaaa tccaatttct
     2941 ccaccaattt tccatggtct ggacacccta accgtgatgg gcattgcgtt tgcagccttt
     3001 gtgatcggag cactcctgac gggggccttg tggtacatct attctcacac aggggagaca
     3061 gcaggaaggc agcaagtccc cacctccccg ccagcctcgg aaaacagcag tgctgcccac
     3121 agcatcggca gcacgcagag cacgccttgc tccagcagca gcacggccta gcccaaccca
     3181 ggcccaaccc ggcccaaccc agcccagccc agctcagctc agctactcca agggcaggac
     3241 caatggctga gcctcgtgtc cagactcaga gggctggatt ttggttccct tgtaaagaca
     3301 gagtgaattt cagtataaag atcacccgtt gtattcaccc cacacccagg gctagtataa
     3361 acatgaccct gggcttctgt accacactag aattcatgtg agaaagctaa aatggtggtc
     3421 ttctccacca gcccctcaca ggcttggggg ttttctatgt gaaacacatg ccagttttta
     3481 aaatgctgct ttgtccaggt gagaacatcc ataatttggg gccctgagtt ttacccagac
     3541 tcaaggagtt ggtaaagggt taatagccag atagtagaac cagtgaggag atgcggccaa
     3601 agattcttta tatctgaacc aagatgtaaa acaagaaatg ctttgaggct ttctaagcga
     3661 tcctcctgtc taatttgcac ctttgtctgg atgcactctt ctgaccttgc tgccacaacc
     3721 tgtggggtct gatgtgtccc aagatgggtg ctgccctcag ggactgcacc ctgacaagtg
     3781 ttaaggcaac attccttgct tgtgccctgg gccaaaacca atgctgatga ccttatcagc
     3841 ttcctgtttc ttcccatact gcatacacca ctgcaaaatg tcttaatgca aattttgtat
     3901 ttcttacagg cctacagaaa ttgaaaatga ccaaaatcag gaaccacaga tttgtgccca
     3961 ttcctaatat tttgttctgc aaattaatgt ataatttgag gtgaaattca gttataaagt
     4021 caaggacgaa tttgcacagt gatatatttc tatgtgtatg caagtacaag tatataatat
     4081 gtcacctggc acattcattt tctcagttga agaagagaaa atttgaaaat gtccttatgc
     4141 ttttagagtt gcaacttaag tatatttggt agggtgagtg tttccactca aaatatgtca
     4201 acttaaaaaa aaataggccc tttcataaaa accaaactgt agcaagatgc aaatgcatgg
     4261 caaatctgtc ggtctccagt tggttatctg aatagtgtca ccaattccac caagacagtg
     4321 ctgagattgg aaagggcact catttggatt gccttacttc tcttgcctta aatatatccc
     4381 atatatttaa tatgtcaaaa agggcttgag gtgaatttca ttaaatggaa taatatgatg
     4441 ccactttgca gctaaaataa gctcagtgat acctccttgt taaaaaaaaa aaaaaaaagg
     4501 atcccccggg ctgcaggaat tc
//