From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Madagascar periwinkle hydroxymethylglutaryl-CoA reductase (HMGR)
Date: 29 Dec 92 01:27:21 GMT
Distribution: bionet
Checksum: 48241 6

LOCUS       CTRHMGR      2636 bp ss-mRNA            PLN       08-DEC-1992
DEFINITION  Madagascar periwinkle hydroxymethylglutaryl-CoA reductase (HMGR)
            mRNA, complete cds.
ACCESSION   M96068
KEYWORDS    hydroxymethylglutaryl-CoA reductase.
SOURCE      Catharanthus roseus (cultivar Little Delicata) seedling cDNA to
            mRNA.
  ORGANISM  Catharanthus roseus
            Eukaryota; Plantae; Embryobionta; Magnoliophyta; Magnoliopsida;
            Asteridae; Gentianales; Apocynaceae.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Maldenado-Mendoza,I.E., Burnett,R.J. and Nessler,C.L.
  TITLE     Nucleotide sequence of a cDNA encoding
            3-hydroxy-3-methylglutaryl-CoA reductase from Catharanthus roseus
  JOURNAL   Plant Physiol. 100, 1613-1614 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mat_peptide     126..1928
                     /product="hydroxymethylglutaryl-CoA reductase"
                     /gene="HMGR"
                     /codon_start=1
     CDS             126..1931
                     /EC_number="1.1.1.34"
                     /standard_name="3-hydroxy-3-methylglutaryl-CoA reductase"
                     /gene="HMGR"
                     /product="hydroxymethylglutaryl-CoA reductase"
                     /codon_start=1
                     /translation="MDSRRRSPTVTAKAAAGELPLAPHEGQNQQPSIPRSSDVLPLPL
                     YLANGVFFTLFFSVMYFLLTRWREKIRNATPLHVVTLSELAALASLIASVIYLVSFFG
                     LDFVQSLIYKPNNEGWEIEEEILMVEDSRNGTNCTTLGCAVPPPSVPKIAPVVPQQPS
                     KMVIIEKPAPLITPQNSEEDEDIIKAVVAGKIPSYSLESKLGDCKRAAGIRREALQRI
                     TGKSLEGLPLEGFDYASILGQCCEMPVGYVQLPVGIAGPLLLDGREYMLPMATTEGCL
                     VASTNRGCKAILASGGANSVLLRDGMTRAPVVRFGTAKRAAELKFYMEDTQNFETISV
                     VFNKSSRFAKLQSVQCAIAGKNLYIRFSCSTGDAMGMNMVSKGVQNVLEFLQTDYPDM
                     DVLGISGNFCADKKPAAVNWIEGRGKSVVCEAIIKEEIVKTVLKTEVAALIELNMVKN
                     LAGSAIAGALGGFNAHASNIVSAIFIATGQDPAQNVESSQCITMMEAVNDGKDLHISV
                     TMPSIEVGTVGGGTQLASQSACLNLLGVKGASKDSPGANSRLLATIVAGSVLAGELSL
                     MSAISAGQLVRSHMKYNRSSKDITNIASSQLESDS"
BASE COUNT      715 a    550 c    596 g    775 t
ORIGIN      
        1 ccacaaccac cgtcaccgct tccgtcctct cccctcctaa tctccgccac tggccacccc
       61 attctttctc tttcctccac taccaccccc acccttctca ctctagacct ttgtgcaaac
      121 agaaaatgga ctctcgccgg cgatcaccaa ctgtgacggc aaaggctgct gccggtgaac
      181 tgccattggc acctcacgaa ggccaaaatc aacagccttc cattcctagg tcttccgatg
      241 ttttaccttt gcctctgtat ctcgcaaatg gggttttctt taccctgttt ttctctgtta
      301 tgtactttct tctgaccagg tggcgtgaga agatccgaaa tgctactcct ctccatgtcg
      361 tcactctttc tgagcttgcc gccttggcct cattaatcgc ttctgtgatt tatcttgtga
      421 gtttctttgg gcttgacttt gttcagtcct taatttacaa gcctaataat gaaggttggg
      481 aaattgaaga agaaattctt atggtggaag atagccgcaa cggtactaat tgtactaccc
      541 taggttgcgc tgtccctcca ccatctgttc ccaaaattgc cccagtcgtt cctcaacaac
      601 cttctaaaat ggtcatcata gagaagcctg cccctctcat taccccacaa aattcagagg
      661 aagatgagga tattatcaaa gcggtggttg ctggaaaaat tccttcgtat tctctcgagt
      721 caaaactggg ggactgcaag agagctgctg gaattcgtag ggaagcgctt cagaggatca
      781 cagggaagtc attggagggg ttacctcttg agggttttga ttatgcatct attttgggtc
      841 agtgctgtga gatgccggtg ggttatgtac agttgccggt tggaatagct gggcctttgt
      901 tgcttgatgg gagagaatat atgttgccaa tggctactac agaagggtgt ttagtggcta
      961 gtactaacag gggttgtaaa gctattcttg catctggtgg ggcaaatagc gttttgctca
     1021 gagatggaat gactagggct cctgttgtga ggtttggaac tgcaaaaaga gccgctgagc
     1081 tcaagttcta catggaggat acccagaatt ttgagactat atctgtagtt ttcaacaaat
     1141 cgagcagatt tgccaaattg caaagcgtcc aatgtgcaat tgcagggaag aatttgtaca
     1201 taaggtttag ctgcagtact ggtgatgcaa tggggatgaa catggtctca aagggcgtac
     1261 aaaatgttct tgaatttctc cagactgatt atcctgatat ggatgtcctt gggatttctg
     1321 gaaatttctg tgctgacaag aaaccagcag cagtcaactg gattgaagga agaggtaaat
     1381 ctgtagtttg tgaggctatc ataaaggaag agattgtaaa gacggtattg aagacagaag
     1441 ttgcggccct tattgagctt aacatggtta aaaatctcgc tggatctgca attgctggag
     1501 cccttggtgg attcaatgct catgccagca atatagtctc tgccatattt attgccaccg
     1561 gccaagatcc tgctcagaat gtggagagct ctcagtgtat cactatgatg gaggctgtca
     1621 atgatggcaa agatcttcat atttctgtca ccatgccttc tattgaggtg ggcacagttg
     1681 gtggaggtac tcaacttgca tctcagtcag catgtttgaa cttgcttgga gtaaaaggtg
     1741 ccagcaaaga ctcacctggt gcaaattcaa ggctcttggc taccattgtt gctggttcag
     1801 ttcttgcagg tgagctttcc ctcatgtctg ccatttctgc aggccaactc gttaggagcc
     1861 acatgaaata caaccgttct agcaaggata taaccaacat agcctcctct cagttagaga
     1921 gtgatagtta aatacaatcc cttccccctc ccccccttaa accccacctt gttagttagt
     1981 ataggccata gaagaaatcc ccaaaaaaaa aaaaaaaaaa aaggttatga agttaataaa
     2041 caaatcaaga aaggggtggt gaataaaaaa aatatataaa acccccaaaa aaaaaaaagg
     2101 aaagagaata gggtgtattg gtggtgaata tgatatgtga gaaggagaaa tgaaggaaga
     2161 aacagacaaa ggcaaactac atctgttgca agaagggagt catgtgatgc tgctctacct
     2221 ctctttctct ctcctctttc tctctctatt tcttgaatga agttgtcctg aagtcatggg
     2281 gaacagtagc tggctggctg gctgggtgca ccgtggagaa agaagaatct gtttgtttaa
     2341 ttatttgtat cttttgtaat gtcattttgg catcaagaaa tggaaagaga agaggcagtt
     2401 aaggttagag tttggtggca ttcatgtgca aaggaagatt ttactcttaa tttttagtat
     2461 gtttttaata taatcttctt cttcactgtc tctctctctc tctctctctc tctctctctg
     2521 gtttgttgtt aacagcagtg attagttagt aattaagaca gagcatttca aaaacatgag
     2581 actctgatct gtcttacaag tttgtgtaaa tggaaaaaat gttttattct tcaaaa
//