From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse mRNA for protein-tyrosine kinase substrate p36 (calpactin I
Date: 21 Jul 92 10:07:25 GMT
Distribution: bionet
Checksum: 53547     4

LOCUS       MUSP36       1307 bp ss-mRNA            ROD       21-JUL-1992
DEFINITION  Mouse mRNA for protein-tyrosine kinase substrate p36 (calpactin I
            heavy chain), complete cds.
ACCESSION   D10024 D00018
KEYWORDS    Ca2+/phospholipid-binding; phospholipase A2 inhibitor;
            protein-tyrosin kinase.
SOURCE      Mus musculus cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Saris,C.J., Tack,B.F., Kristensen,T., Glenney,J.R.Jr. and Hunter,T.
  TITLE     The cDNA sequence for the protein-tyrosine kinase substrate p36
            (calpactin I heavy chain) reveals a multidomain protein with
            internal repeats
  JOURNAL   Cell 46, 201-212 (1986)
  STANDARD  full staff_review
COMMENT     A cDNA for the protein-tyrosine kinase substrate, p36 (calpactin I
            heavy chain) was cloned and sequenced. The sequence predicts a 339
            amino acid protein (molecular weight 38493). The composition
            indicates that p36 is rich in charged amino acids (32.2 %). The
            sequence homology between p36 and the phospholipase A-2 inhibitor,
            lipocortin I are found to be about 50 % , suggesting that both are
            functionally related. The function of p36 and its kins are
            discussed.
FEATURES             Location/Qualifiers
     CDS             8..1027
                     /product="protein-tyrosine kinase substrate p36"
                     /codon_start=1
                     /translation="MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIET
                     AVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGL
                     LKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDII
                     SDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMT
                     ERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYD
                     SMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYL
                     CGGDD"
     mat_peptide     11..1024
                     /product="protein-tyrosine kinase substrate p36"
                     /codon_start=1
     polyA_signal    1287..1292
     polyA_site      1307
BASE COUNT      349 a    338 c    342 g    278 t
ORIGIN
        1 cttcaaaatg tctactgtcc acgaaatcct gtgcaagctc agcctggagg gtgatcattc
       61 tacaccccca agtgcctacg ggtcagtcaa accctacacc aacttcgatg ctgagaggga
      121 tgctctgaac attgagacag cagtcaagac caaaggagtg gatgaggtca ccattgtcaa
      181 catcctgaca aaccgcagca atgtgcagag gcaggacatt gccttcgcct atcagagaag
      241 gaccaaaaag gagctcccgt cagcgctgaa gtcagcctta tctggccacc tggagacggt
      301 gattttgggc ctattgaaga cacctgccca gtatgatgct tcggaactaa aagcttccat
      361 gaagggcctg gggactgacg aggactccct cattgagatc atctgctccc gaaccaacca
      421 ggagctgcaa gagatcaaca gagtgtacaa ggaaatgtac aagactgatc tggagaagga
      481 catcatctct gacacatctg gagacttccg aaagctgatg gtcgcccttg caaagggcag
      541 acgagcagag gatggctcag ttattgacta cgagctgatt gaccaggatg cccgggagct
      601 ctatgatgcc ggggtgaaga ggaaaggaac cgacgtcccc aagtggatca gcatcatgac
      661 tgagcgcagt gtgtgccacc tccagaaagt gttcgaaagg tacaagagct acagccctta
      721 tgacatgctg gagagcatca agaaagaggt caaaggggac ctggagaacg ccttcctgaa
      781 cctggtccag tgcatccaga acaagcccct gtacttcgct gaccggctgt acgactccat
      841 gaagggcaag gggactcgag acaaggtcct gattagaatc atggtctctc gcagtgaagt
      901 ggacatgctg aaaatcagat ctgaattcaa gaggaaatat ggcaagtccc tgtactacta
      961 catccagcaa gacaccaagg gtgactacca gaaggcactg ctgtacctgt gtggtgggga
     1021 tgactgaagg gctcagcaca gtggatcacc cagaagtggc tctacctgtg ccccaacctg
     1081 gcgttctaga gacttcgctc tccactaatg gacccctgag ctcctccctg tgaggatgat
     1141 gacagggctg ccgacccttt ccccatctta gctgcccttg cctggctttc tcctcattct
     1201 ctcctttatg ccaaagaagt gaacattcca gggagtgggg cgtcagtctg tgacatgaga
     1261 cacttcctct tatgtactgt gtcgtgaata aaccgttttt actttag
//