From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rat peptidylglycine alpha-amidating monooxygenase (PAM) gene, exon
Date: 28 Dec 92 21:44:37 GMT
Distribution: bionet
Checksum: 01281 4

LOCUS       RATPAM01      535 bp ds-DNA             ROD       01-DEC-1992
DEFINITION  Rat peptidylglycine alpha-amidating monooxygenase (PAM) gene, exon
            2.
ACCESSION   L01668
KEYWORDS    alternative splicing;
            peptidylglycine alpha-amidating monooxygenase.
SEGMENT     1 of 26
SOURCE      Rattus norvegicus (strain Sprague-Dawley) (library: lambda Fix)
            male adult liver DNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (sites)
  AUTHORS   Stoffers,D.A., Green,C.B.-R. and Eipper,B.A.
  TITLE     Alternative mRNA splicing generates multiple forms of
            peptidylglycine alpha-amidating monooxygenase in rat atrium
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86, 735-739 (1989)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Bertelson,A.H., Beaudry,G.A., Galella,E.A., Jones,B.N., Ray,M.L.
            and Mehta,N.M.
  TITLE     Cloning and characterization of two alternatively spliced rat
            alpha-amidating enzyme cDNAs from rat medulla thyroid carcinoma
  JOURNAL   Arch. Biochem. Biophys. 279, 87-96 (1990)
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   Stoffers,D.A., Ouafik,L. and Eipper,B.A.
  TITLE     Characterization of novel mRNAs encoding enzymes involved in
            peptide alpha-amidation
  JOURNAL   J. Biol. Chem. 266, 1701-1707 (1991)
  STANDARD  full automatic
REFERENCE   4  (sites)
  AUTHORS   Eipper,B.A., Green,C.B., Campbell,T.A., Stoffers,D.A.,
            Keutmann,H.T., Mains,R.E. and Ouafik,L.
  TITLE     Alternative splicing and endoproteolytic processing generate
            tissue-specific forms of peptidylglycine alpha-amidating
            monooxygenase (PAM)
  JOURNAL   J. Biol. Chem. 267, 4008-4015 (1992)
  STANDARD  full automatic
REFERENCE   5  (bases 1 to 535)
  AUTHORS   Ouafik,L., Stoffers,D.A., Campbell,T.A., Johnson,R.C.,
            Bloomquist,B.T., Mains,R.E. and Eipper,B.A.
  TITLE     The multifunctional peptidylglycine alpha-amidating monooxygenase
            gene: Exon/intron organization of catalytic, processing and routing
            domains
  JOURNAL   Mol. Endocrinol. 6, 1571-1584 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     intron          1..113
                     /number=1
                     /gene="PAM"
     exon            114..518
                     /number=2
     sig_peptide     415..489
                     /gene="PAM"
                     /codon_start=1
BASE COUNT       77 a    180 c    171 g    107 t
ORIGIN      
        1 aggcttgggg ccaagctgtg aaactcctgg tgtattaagg aacctcagct ggatttgctg
       61 aggacaaatg ctgtaatgtg ttagtcatcc attatctgct tctatttttg caggttccga
      121 atgatgactg acgcgggtct gcgcgatagc cctcacagcc cctggcattg cgagcgataa
      181 ggaccctgct cctccagccc tgtggctgcc accggctctg gccgctctgg agggcgggcg
      241 gctccagcgg gcgggcggac ggactccaga gccgcttccc acgcgtcggg agcggaccga
      301 gcggacccgg ctggccgcgc atcgccctcg cccggggcca tgaagtagct gccgccgcca
      361 gccctgccat cccgccggcc cggccactgc ccgctgccct ggtcctgcgc ggacatggcc
      421 ggacgcgccc gcagcggtct gctactgctg ctgctggggc tgctcgccct gcagagcagc
      481 tgcctggcct tcagaagccc actttctgtc tttaagaggt gcgtgctcgg cttgt
//