From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens factor VIII (F8C) gene, exon 26.
Date: 29 Dec 92 20:56:26 GMT
Distribution: bionet
Checksum: 43366 9

LOCUS       HUMFAC21     2709 bp ds-DNA             PRI       11-DEC-1992
DEFINITION  H.sapiens factor VIII (F8C) gene, exon 26.
ACCESSION   M88648
KEYWORDS    coagulation factor; factor VIII.
SEGMENT     21 of 21
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Gitschier,J. and Wood,W.I.
  TITLE     Sequence of the exon-containing regions of the human factor VIII
            gene
  JOURNAL   Hum. Mol. Genet. 1, 199-200 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            253..2211
                     /number=26
                     /gene="F8C"
                     /evidence="EXPERIMENTAL"
     mRNA            join(M88628:1006..1318,M88629:221..342,M88630:101..223,
                     M88631:46..258,M88632:104..172,M88633:387..503,
                     M88634:51..272,M88635:303..564,M88636:282..375,
                     M88637:39..253,M88638:91..241,M88639:168..377,
                     M88640:627..3732,M88641:158..311,M88642:1051..1263,
                     M88642:1550..1778,M88642:1986..2168,M88642:3904..4020,
                     M88642:4627..4698,M88643:39..124,M88644:42..197,
                     M88645:542..686,M88646:75..223,M88647:109..285,253..2211)
                     /gene="F8C"
     CDS             join(M88628:1176..1318,M88629:221..342,M88630:101..223,
                     M88631:46..258,M88632:104..172,M88633:387..503,
                     M88634:51..272,M88635:303..564,M88635:849..1020,
                     M88636:282..375,M88637:39..253,M88638:91..241,
                     M88639:168..377,M88640:627..3732,M88641:158..311,
                     M88642:1051..1263,M88642:1550..1778,M88642:1986..2168,
                     M88642:3904..4020,M88642:4627..4698,M88643:39..124,
                     M88644:42..197,M88645:542..686,M88646:75..223,
                     M88647:109..285,253..408)
                     /gene="F8C"
                     /product="coagulation factor VIII"
                     /codon_start=1
                     /translation="MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELP
                     VDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDT
                     VVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVL
                     KENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLF
                     AVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHV
                     IGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSH
                     QHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRS
                     VAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAY
                     TDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSR
                     RLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGL
                     IGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLED
                     PEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMV
                     YEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYED
                     SYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTIPENDIEKTDPWFAHRTPM
                     PKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPSPGAIDSNNSLSEMTHF
                     RPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSSTSNNLISTIPSDNLA
                     AGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEENNDSKLLESGLM
                     NSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTNKTSNNSATNR
                     KTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRLNHMSNKTT
                     SSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSGQGPSPK
                     QLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDNLHEN
                     NTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYDGA
                     YAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT
                     SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNE
                     KEKGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLP
                     AASYRKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKV
                     ENTVLPKPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAI
                     KWNEANRPGKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTA
                     FKKKDTILSLNACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQRE
                     ITRTTLQSDQEEIDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLW
                     DYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRA
                     EVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHM
                     APTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFT
                     IFDETKSWYFTENMERNCRAPSNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQR
                     IRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWR
                     VECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHY
                     SGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQ
                     TYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL
                     NSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEW
                     LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQ
                     DSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY"
BASE COUNT      855 a    545 c    550 g    759 t
ORIGIN      
        1 gcacttaatg tcactgaggt ttgggaagtg ggtgagaaca ctgtagatat aaggcctagc
       61 tagagtgaag gcctccaaag cagggtgctc ttaattctag atgtcccaga tgcgtaggac
      121 agagtcatct agtcatcttc cagggtttaa tcctggacta ctggaaacaa ctagaagtga
      181 gaaaagcgtc tgtgctttgc agtgaccatt gtcctgtcag acaaccaata aatgctatct
      241 ttcctctttc aggtttttca gggaaatcaa gactccttca cacctgtggt gaactctcta
      301 gacccaccgt tactgactcg ctaccttcga attcaccccc agagttgggt gcaccagatt
      361 gccctgagga tggaggttct gggctgcgag gcacaggacc tctactgagg gtggccactg
      421 cagcacctgc cactgccgtc acctctccct cctcagctcc agggcagtgt ccctccctgg
      481 cttgccttct acctttgtgc taaatcctag cagacactgc cttgaagcct cctgaattaa
      541 ctatcatcag tcctgcattt ctttggtggg gggccaggag ggtgcatcca atttaactta
      601 actcttacct attttctgca gctgctccca gattactcct tccttccaat ataactaggc
      661 aaaaagaagt gaggagaaac ctgcatgaaa gcattcttcc ctgaaaagtt aggcctctca
      721 gagtcaccac ttcctctgtt gtagaaaaac tatgtgatga aactttgaaa aagatattta
      781 tgatgttaac atttcaggtt aagcctcata cgtttaaaat aaaactctca gttgtttatt
      841 atcctgatca agcatggaac aaagcatgtt tcaggatcag atcaatacaa tcttggagtc
      901 aaaaggcaaa tcatttggac aatctgcaaa atggagagaa tacaataact actacagtaa
      961 agtctgtttc tgcttcctta cacatagata taattatgtt atttagtcat tatgaggggc
     1021 acattcttat ctccaaaact agcattctta aactgagaat tatagatggg gttcaagaat
     1081 ccctaagtcc cctgaaatta tataaggcat tctgtataaa tgcaaatgtg catttttctg
     1141 acgagtgtcc atagatataa agccatttgg tcttaattct gaccaataaa aaaataagtc
     1201 aggaggatgc aattgttgaa agctttgaaa taaaataaca atgtcttctt gaaatttgtg
     1261 atggccaaga aagaaaatga tgatgacatt aggcttctaa aggacataca tttaatattt
     1321 ctgtggaaat atgaggaaaa tccatggtta tctgagatag gagatacaaa ctttgtaatt
     1381 ctaataatgc actcagttta ctctctccct ctactaattt cctgctgaaa ataacacaac
     1441 aaaaatgtaa caggggaaat tatataccgt gactgaaaac tagagtccta cttacatagt
     1501 tgaaatatca aggaggtcag aagaaaattg gactggtgaa aacagaaaaa acactccagt
     1561 ctgccatatc accacacaat aggatccccc ttcttgccct ccacccccat aagattgtga
     1621 agggtttact gctccttcca tctgcctgac cccttcacta tgactacaca gaatctcctg
     1681 atagtaaagg gggctggagg caaggataag ttatagagca gttggaggaa gcatccaaag
     1741 attgcaaccc agggcaaatg gaaaacagga gatcctaata tgaaagaaaa atggatccca
     1801 atctgagaaa aggcaaaaga atggctactt ttttctatgc tggagtattt tctaataatc
     1861 ctgcttgacc cttatctgac ctctttggaa actataacat agctgtcaca gtatagtcac
     1921 aatccacaaa tgatgcaggt gcaaatggtt tatagccctg tgaagttctt aaagtttaga
     1981 ggctaactta cagaaatgaa taagttgttt tgttttatag cccggtagag gagttaaccc
     2041 caaaggtgat atggttttat ttcctgttat gtttaactta ataatcttat tttggcattc
     2101 ttttcccatt gactatatac atctctattt ctcaaatgtt catggaacta gctcttttat
     2161 tttcctgctg gtttcttcag taatgagtta aataaaacat tgacacatac aaacaaatgc
     2221 ctttgagaat tgtgttttta cactggaaat aaaaatgtga acactgattt ttaaaacaaa
     2281 taggggcact gaatagcaag atggacactc tagaaaacca aattagtgag ttagaaaacc
     2341 agattaaatt gaactcagag taaaaatgat ataattcatg agagtctgaa taaaataaat
     2401 cagaaatgga gcctcaatcc aggagaacag cttatatgga gagagagaga ctgagagaga
     2461 aatgggagtt tctgttcaat gggcataaag tttcagctat gctgctgggc acagtggctc
     2521 atgcctgtaa tcctggcact ttgggaggcc aaggcgggcg gatcacctga ggtcaggagt
     2581 tcaagaccag cctagccaac atggcgaaat cccgtcgcta ataaaaatat aaaaattagt
     2641 tgggcatggt ggcacatgcc tgtagtccca gctacttggg aggttgaggc acaagaatcg
     2701 cttgaaccc
//