From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse mRNA for receptor tyrosine kinase.
Date: 3 Jan 93 22:16:40 GMT
Distribution: bionet
Checksum: 10158 9

LOCUS       MUSHYK       4676 bp ss-mRNA            ROD       23-DEC-1992
DEFINITION  Mouse mRNA for receptor tyrosine kinase.
ACCESSION   D13738
KEYWORDS    receptor tyrosine kinase.
SOURCE      Mus musculus (strain C57BL/6 x CBA) (library: ES cell cDNA) male
            embryonic stem cell line TT2, cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 4676)
  AUTHORS   Horita,K., Yagi,T., Kohmura,N., Tomooka,Y., Ikawa,Y. and Aizawa,S.
  TITLE     A novel tyrosine kinase, hyk, expressed in murine embryonic stem
            cells
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     Submitted (19-Nov-1992) to DDBJ by; Takashi Yagi Tsukuba Life
            Science Center Physical and Chemical Research Institute (RIKEN)
            3-1-1 Koyadai Tsukuba Ibaraki 305 Japan Phone:  0298-36-5265 Fax:
             0298-36-9020.
FEATURES             Location/Qualifiers
     misc_feature    54..62
                     /note="RGD motif"
     misc_structure  982..2013
                     /note="EGF homology domain 1"
     misc_structure  2014..2154
                     /note="EGF homology domain 2"
     misc_structure  2155..2280
                     /note="EGF homology domain 3"
     CDS             352..3729
                     /gene="hyk"
                     /product="Receptor tyrosine kinase"
                     /codon_start=1
                     /translation="MDSLAGLVLCGVSLLLYGVVEGAMDLILINSLPLVSDAETSLTC
                     IASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC
                     EGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGS
                     LHPLSAPGMKYLDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWG
                     PDCSRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCK
                     SYVFCLPDPYGCSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQ
                     GWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGT
                     VLQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLH
                     APNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEP
                     RTDYELCVQLARPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIF
                     TNSEDEFYVEVERRSLQTTSDQQNIKVPGNLTSVLLSNLVPREQYTVRARVNTKAQGE
                     WSEELRAWTLSDILPPQPENIKISNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNED
                     QHIDVKIKNATVTQYQLKGLEPETTYHVDIFAENNIGSSNPAFSHELRTLPHSPASAD
                     LGGGKDATHSHPWVGWNDFASPCLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFN
                     SGTLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIK
                     RMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF
                     LGKSRVLETDPAFCHRQQYSSTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNIL
                     VGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLW
                     EIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQ
                     ILVSLNRMLEERKTYVNTTLYEKFTYAGIDCPAEEAA"
BASE COUNT     1311 a   1052 c   1154 g   1159 t
ORIGIN      
        1 ccacgcgtcc gagcaggagc cggagcagga gcagaagata agccttggat gaagggcaag
       61 atggataggg ctcgctctgc cccaagccct gctgatacca agtgccttta agatacagcc
      121 tttcccatcc taatctgcaa aggaaacagg aaaaaggaac ttaaccctcc ctgtgctcag
      181 acagaaatga gactgttacc gcctgcttct gtggtgtttc tccttgccgc caacttgtaa
      241 acaagagcga gtggaccatg cgagcgggaa gtcgcaaagt tgtgagttgt tgaaagcttc
      301 ccagggactc atgctcatct gtggacgctg gatggggaga tctggggaag tatggactct
      361 ttagccggct tagttctctg tggagtcagc ttgctccttt atggagtagt agaaggtgcc
      421 atggacctga tcttgatcaa ttccctacct cttgtgtctg atgccgaaac atccctcacc
      481 tgcattgcct ctgggtggca cccccatgag cccatcacca taggaaggga ctttgaagcc
      541 ttaatgaacc agcaccaaga tccactggag gttactcaag atgtgaccag agaatgggcg
      601 aaaaaagttg tttggaagag agaaaaggcc agtaagatta atggtgctta tttctgtgaa
      661 ggtcgagttc gaggacaggc tataaggata cggaccatga agatgcgtca acaagcgtcc
      721 ttcctacctg ctactttaac tatgaccgtg gacaggggag ataatgtgaa catatctttc
      781 aaaaaggtgt taattaaaga agaagatgca gtgatttaca aaaatggctc ccttcatcca
      841 ctcagtgccc ccggcatgaa gtaccttgat attttagaag ttcacttgcc gcatgctcag
      901 ccccaggatg ctggtgtgta ctcggccagg tacataggag gaaacctgtt cacctcagcc
      961 ttcaccaggc tgattgttcg gagatgtgaa gctcagaagt gggggcccga ctgtagccgt
     1021 ccttgtacta cttgcaagaa caatggagtc tgccatgaag ataccgggga atgcatttgc
     1081 cctcctgggt ttatggggag aacatgtgag aaagcttgtg agccgcacac atttggcagg
     1141 acctgtaaag aaaggtgtag tggaccagaa ggatgcaagt cttatgtgtt ctgtctccca
     1201 gacccttacg ggtgttcctg tgccacaggc tggagggggt tgcagtgcaa tgaagcatgc
     1261 ccatctggtt actacggacc agactgtaag ctcaggtgcc actgtaccaa tgaagagata
     1321 tgtgatcggt tccaaggatg cctctgctct caaggatggc aagggctgca gtgtgagaaa
     1381 gaaggcaggc caaggatgac tccacagata gaggatttgc cagatcacat tgaagtaaac
     1441 agtggaaaat ttaaccccat ctgcaaagcc tctgggtggc cactacctac tagtgaagaa
     1501 atgaccctag tgaagccaga tgggacagtg ctccaaccaa atgacttcaa ctatacagat
     1561 cgtttctcag tggccatatt cactgtcaac cgagtcttac ctcctgactc aggagtctgg
     1621 gtctgcagtg tgaacacagt ggctgggatg gtggaaaagc ctttcaacat ttccgtcaaa
     1681 gttcttccag agcccctgca cgccccaaat gtgattgaca ctggacataa ctttgctatc
     1741 atcaatatca gctctgagcc ttactttggg gatggaccca tcaaatccaa gaagcttttc
     1801 tataaacctg tcaatcaggc ctggaaatac attgaagtga cgaatgagat tttcactctc
     1861 aactacttgg agccgcggac tgactacgag ctgtgtgtgc agctggcccg tcctggagag
     1921 ggtggagaag ggcatcctgg gcctgtgaga cgatttacaa cagcgtctat cggactccct
     1981 cctccaagag gtctcagtct cctgccaaaa agccagacag ctctaaattt gacttggcaa
     2041 ccgatattta caaactcaga agatgaattt tatgtggaag tcgagaggcg atccctgcaa
     2101 acaacaagtg atcagcagaa catcaaagtg cctgggaacc tgacctcggt gctactgagc
     2161 aacttagtcc ccagggagca gtacacagtc cgagctagag tcaacaccaa ggcgcagggg
     2221 gagtggagtg aagaactcag ggcctggacc cttagtgaca ttctccctcc tcaaccagaa
     2281 aacatcaaga tctccaacat cactgactcc acagctatgg tttcttggac aatagtggat
     2341 ggctattcga tttcttccat catcatccgg tataaggttc agggcaaaaa tgaagaccag
     2401 cacattgatg tgaagatcaa gaatgctacc gttactcagt accagctcaa gggcctagag
     2461 ccagagacta cataccatgt ggatattttt gctgagaaca acataggatc aagcaaccca
     2521 gccttttctc atgaactgag gacgcttcca cattccccag cctctgcaga cctcggaggg
     2581 gggaaagatg ctactcatag ccatccttgg gtcggctgga atgactttgc atcaccgtgc
     2641 ttgttggcgt ttctgattat gttgcaactg aagagagcaa atgtccaaag gagaatggct
     2701 caggcattcc agaacgtgag agaagaacca gctgtgcagt ttaactcagg aactctggcc
     2761 cttaacagga aggccaaaaa caatccggat cccacaattt atcctgtgct tgactggaat
     2821 gacatcaagt ttcaagacgt gatcggagag ggcaactttg gccaggttct gaaggcacgc
     2881 atcaagaagg atgggttacg gatggatgcc gccatcaaga ggatgaaaga gtatgcctcc
     2941 aaagatgatc acagggactt cgcaggagaa ctggaggttc tttgtaaact tggacaccat
     3001 ccaaacatca tcaatctctt gggagcatgt gaacaccgag gctatttgta cctagctatt
     3061 gagtatgccc cgcatggaaa cctcctggac ttcctgggta agagcagagt gctagagaca
     3121 gaccctgctt tttgccatcg ccaacagtac agttccacac tgtcctccca acagcttctt
     3181 cattttgctg cagatgtggc ccgggggatg gactacttga gccagaaaca gtttatccac
     3241 agggacctgg ctgccagaaa cattttagtt ggtgaaaact acatagccaa aatagcagat
     3301 tttggattgt cacgaggtca agaagtgtat gtgaaaaaga caatgggaag gctcccagtg
     3361 cgttggatgg caatcgaatc actgaactat agtgtctata caaccaacag tgatgtctgg
     3421 tcctatggtg tattgctctg ggagattgtt agcttaggag gcacccccta ctgcggcatg
     3481 acgtgcgcgg agctctatga gaagctaccc cagggctaca ggctggagaa gcccctgaac
     3541 tgtgatgatg aggtgtatga tctaatgaga cagtgctgga gggagaagcc ttatgagaga
     3601 ccatcatttg cccagatatt ggtgtcctta aacaggatgc tggaagaacg gaagacatac
     3661 gtgaacacca cactgtatga gaagtttacc tatgcaggaa ttgactgccc tgcggaagaa
     3721 gcagcctaga gcagaactct tcatgtacaa cggccatttc tcctcactgg cgcgagacct
     3781 ttgtacacct gtaccaagca agccacccac tgccaagaga tgtgatatat aagtttatat
     3841 attgtgctgt gtttgggacc ctcctcatac agttcgtgcg gatctgcagt gtgttctgac
     3901 tctaatgtga ctgtatatac tgctcggagt aagaatgtgc taagatcaga atgcctgtcc
     3961 gtggtttcat ctaatatatt ttcctaaaag catagattgc acaggaaggt atgagtacaa
     4021 atactgtaat gcataacttg ttattgtcct agatgtgttt gatattttcg ctttacaact
     4081 gaatgctata aaagtgtttt gctgtgtaca cataagatac tgttcgttaa aataagcatt
     4141 cccttgacag cacaggaaga aaagcgaggg aaatgtatgg attatattaa atgtgggtta
     4201 ctacacaaga ggccgaacat tccaagtagc agaagagagg gtctctcaac tctgctcctc
     4261 acctgcagaa gccagtttgt ttggccatgt gacaattgtc ctgtgttttt atagcaccca
     4321 aatcattcta aaatatgaac atctaaaaac tttgctagga gactaagaac ctttggagag
     4381 atagatataa gtacggtcaa aaaacaaaac tgcgggactt acatttattt tctatagtaa
     4441 tctgttgtac attttaagga ggtaaactag gatttaggag tgatgtgtga catttctgcc
     4501 atggagttac catccccaca tgtatcacat actgcatatt cccacatgta tcacacatgt
     4561 attgtaaaat tttgtagttt tgatcacttg tgaatttact gttgatgtgg tagccacctg
     4621 ctgcaatggt tcctcttgta ggtgaataaa tgtcttgtct acccacaaaa aaaaaa
//