From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human endothelial leukocyte adhesion molecule I (ELAM-1) gene,
Date: 10 Apr 92 10:05:56 GMT
Distribution: bionet
Checksum: 28696     4

LOCUS       HUMELAMB     1566 bp ds-DNA             PRI       10-APR-1992
DEFINITION  Human endothelial leukocyte adhesion molecule I (ELAM-1) gene,
            exons 1 and 2.
ACCESSION   M64485
KEYWORDS    endothelial leukocyte adhesion molecule I.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Collins,T., Williams,A., Johnston,G.I., Kim,J., Eddy,R., Shows,T.,
            Gimbrone,M.A. and Bevilacqua,M.P.
  TITLE     Structure and chromosomal location of the gene for
            endothelial-leukocyte adhesion molecule 1
  JOURNAL   J. Biol. Chem. 266, 2466-2473 (1991)
  STANDARD  full staff_entry
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Pohlman,T.H., Harlan,J.M., Lobb,R., Bomsztyk,K., Tarr,P.I.,
            Vassallo,C., Goff,D., Tizard,R., Hession,C., Osborn,L. and
            Montgomery,K.F.
  TITLE     Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1)
            gen transcription
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88, 6523-6527 (1991)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     mRNA            join(841..948,1259..1390)
                     /partial
     misc_binding    341..347
                     /bound_moiety="'AP-1'"
     misc_binding    747..758
                     /bound_moiety="'NF-kappa B'"
     CAAT_signal     774..777
     TATA_signal     811..817
     exon            841..948
                     /number=1
     intron          949..1258
                     /number=1
     conflict        1239..1242
                     /note="replace (1239..1242,'ttt')"
                     /citation=[1]
     exon            1259..1390
                     /number=2
     intron          1391..>1566
                     /number=2
BASE COUNT      441 a    316 c    295 g    514 t
ORIGIN
        1 gcatgcgcca ccatgcccag ctaattttgt atttttagta gagatggcgt ttctccatgt
       61 tggtcaggct ggtcttgaac tcccggcctc aggtgatccg cctgcctcgg cctcccaaag
      121 tggtgggatt acaggcgtga gccactgtgc ctggcctcct ttttattttt ttcactgaac
      181 aaaccatgaa actttcccag atgtaaatat ctatttccca tttttctttt tttaaaataa
      241 ggcattattt taaccatttg agtgttagat attattttta gataatattt taatttaggc
      301 ataactgccg tgcaaaatct gaagattaat atctaccttg tgagtcattc ctctgtgaga
      361 cagtgcatgt taaatatgtt gaattggcag gtgaaaaagg aagaaaaaat gagtagtgat
      421 tggttatcca cagctatgaa tgagaaattg aaggtagtag actatggatg acaaacctat
      481 tcttggtttc cttctgtttc tgaaattcta attactacca caactacatg agagacacta
      541 ctaacaagca aagttttaca actttttaaa gacatagact ttatgttatt ataattaaaa
      601 atcatgcatt tttgtcatat taataaaatt gcatatacga tataaaggca tggacaaagg
      661 tgaagtagct tcaagagaca gagtttctga catcattgta attttaagca tcgtggatat
      721 tcccgggaaa gtttttggat gccattgggg atttcctctt tactggatgt ggacaatatc
      781 ctcctattat tcacaggaag caatccctcc tataaaaggg cctcagccga agtagtgttc
      841 agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag
      901 tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg taagtgcaga
      961 acgctttata agggcagcct cgggccatga aacacagata tgcaaaaggc cttctaataa
     1021 aaaccacatc tgtacaagct cttattgtat tgtagctaaa acctgtcttt tctctttgac
     1081 ctaaataatg aaagtcttaa aatttgttta tttatttgat taaactctga aataaagatt
     1141 attgcactag tgtcctttgc ccaaaatctt aggatgctgc cttaaacatc atggtagaat
     1201 aatgtaacta gctacccacg atttccttct ttaattcatt ttgtgtttta tctccccagg
     1261 aaagtatttc aagcctaaac ctttgggtga aaagaactct tgaagtcatg attgcttcac
     1321 agtttctctc agctctcact ttgggtaagt cagtgccatt agaccaagat ttctcattct
     1381 cgcactatag atatttcaga ctgaaatatc cttgcttgtc tggggctgtc ctgcacagga
     1441 tatctggcag catccttgac ctctacctgc aatgtgttct tccctgggct tggggtcatt
     1501 tactttacct cttggtgtct ccctttcctt aagtgtaaag tgtggatccg ttgacctgca
     1561 ggtcga
//