From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mus musculus E-selectin protein mRNA, complete cds.
Date: 27 Aug 92 10:00:30 GMT
Distribution: bionet
Checksum: 50099     6

LOCUS       MUSESELEC    2911 bp ss-mRNA            ROD       27-AUG-1992
DEFINITION  Mus musculus E-selectin protein mRNA, complete cds.
ACCESSION   M87862
KEYWORDS    E-selectin; ELAM-1; endothelial leukocyte adhesion molecule 1.
SOURCE      Mus musculus (strain ICR) (library: lambda gt 10) endothelial cDNA
            to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Weller,A., Isenmann,S. and Vestweber,D.
  TITLE     Cloning of the mouse endothelial selectins: Expression of both E-
            and P-selectin is inducible by tumor necrosis factor alpha
  JOURNAL   J. Biol. Chem. 267, 15176-15183 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             116..1975
                     /product="E-selectin"
                     /codon_start=1
                     /translation="MKATAGVMNASRFLSALVFVLLAGESTAWYYNASSELMTYDEAS
                     AYCQRDYTHLVAIQNKEEINYLNSNLKHSPSYYWIGIRKVNNVWIWVGTGKPLTEEAQ
                     NWAPGEPNNKQRNEDCVEIYIQRTKDSGMWNDERCNKKKLALCYTASCTNASCSGHGE
                     CIETINSYTCKCHPGFLGPNCEQAVTCKPQEHPDYGSLNCSHPFGPFSYNSSCSFGCK
                     RGYLPSSMETTVRCTSSGEWSAPAPACHVVECEALTHPAHGIRKCSSNPGSYPWNTTC
                     TFDCVEGYRRVGAQNLQCTSSGIWDNETPSCKAVTCDAIPQPQNGFVSCSHSTAGELA
                     FKSSCNFTCEQSFTLQGPAQVECSAQGQWTPQIPVCKAVQCEALSAPQQGNMKCLPSA
                     SGPFQNGSSCEFSCEEGFELKGSRRLQCGPRGEWDSKKPTCSAVKCDDVPRPQNGVME
                     CAHATTGEFTYKSSCAFQCNEGFSLHGSAQLECTSQGKWTQEVPSCQVVQCPSLDVPG
                     KMNMSCSGTAVFGTVCEFTCPDDWTLNGSAVLTCGATGRWSGMPPTCEAPVSPTRPLV
                     VALSAAGTSLLTSSSLLYLLMRYFRKKAKKFVPASSCQSLQSFENYHVPSYNV"
     sig_peptide     116..199
                     /codon_start=1
     mat_peptide     200..1972
                     /note="lectin, EGF, and transmembrane domains"
                     /product="E-selectin"
                     /codon_start=1
     repeat_region   674..1807
                     /rpt_type=tandem
                     /rpt_unit=674..862
BASE COUNT      813 a    680 c    703 g    715 t
ORIGIN
        1 cacagcaaaa ctgcgagaag aacggataga gagaagcagg agcaatacac ctaagggatc
       61 caacgccaga acaacaattc cactgaacag aaagtttctc cagtctagcg cctggatgaa
      121 agcaactgct ggagtcatga atgcctcgcg ctttctctct gctcttgttt ttgttctcct
      181 cgctggagag agcacagctt ggtactacaa tgcctccagt gagctcatga cgtatgatga
      241 agccagtgca tactgtcagc gggactacac acatctggtg gcgattcaga acaaggaaga
      301 gatcaactac cttaactcca atctgaaaca ttcaccgagt tactactgga ttggaatcag
      361 aaaagtcaat aacgtatgga tctgggtggg gacggggaag cctctgacag aggaagctca
      421 gaactgggct ccaggtgaac caaacaacaa acaaagaaat gaggactgtg tagagattta
      481 catccaacga accaaagact cgggcatgtg gaatgacgag agatgtaaca aaaagaagct
      541 ggctctgtgc tacacagctt cgtgtaccaa tgcatcctgc agtggtcatg gtgaatgcat
      601 agagaccatc aatagttaca cctgcaagtg ccaccctggc ttcctgggac ccaactgtga
      661 gcaagctgtg acttgcaaac cacaggaaca ccctgactat ggaagcctga actgctccca
      721 cccgttcggc cccttcagct ataattcctc ctgctccttt ggctgtaaaa ggggctacct
      781 gcccagcagc atggagacca ccgtgcggtg tacgtcctct ggagagtgga gtgcgcctgc
      841 tccagcctgc catgtggttg aatgtgaagc tttgacccac cctgcccacg gtatcaggaa
      901 atgttcctca aatcctggga gctacccatg gaacacgaca tgcacgtttg actgtgtgga
      961 agggtacagg cgagttggag ctcagaatct acagtgtacc tcatctggca tctgggataa
     1021 cgagacgcca tcatgcaaag ctgtgacctg tgacgccatc cctcagcctc agaatggctt
     1081 tgtgagctgc agccactcaa cagctggaga acttgcgttt aagtcatcct gtaacttcac
     1141 ctgtgagcag agtttcacgt tgcaggggcc agcgcaggtt gaatgcagcg cacaagggca
     1201 gtggacacca caaatcccag tctgcaaagc tgtccagtgt gaagccttat ctgcgccaca
     1261 gcagggcaac atgaaatgtc ttcccagtgc ttctggacct ttccaaaatg ggtccagttg
     1321 tgagttctcc tgcgaagaag gatttgaact gaagggatca agaagacttc agtgtggtcc
     1381 aagaggggaa tgggatagca agaagcccac gtgttcagct gtgaaatgtg atgatgtccc
     1441 tcggccccag aatggcgtca tggagtgtgc tcatgctact actggagaat tcacctacaa
     1501 gtcctcatgt gcctttcaat gcaatgaggg ctttagcttg catggctcag ctcaacttga
     1561 gtgcacatct cagggaaagt ggacccagga agtcccctcc tgccaagtgg tacaatgtcc
     1621 aagccttgac gtcccgggaa agatgaacat gagctgcagc ggaacagcag ttttcggcac
     1681 agtgtgtgag tttacatgtc ctgatgattg gacactcaat ggatctgcag ttctgacgtg
     1741 tggtgccacg ggacgctggt ctgggatgcc gcctacctgt gaagccccag tcagccccac
     1801 ccgtcccttg gtagttgcac tttctgcggc aggaacctca ctcctgacat cgtcctcatt
     1861 gctctacttg ttgatgagat actttcggaa gaaagcaaag aaatttgttc ctgctagcag
     1921 ctgccaaagc cttcaatcat ttgaaaacta ccatgtgcct tcttacaacg tctaggttca
     1981 aaacaatcag gaacacaaat gcatcgtggg aaatagaatg ataagctgaa gacagcagga
     2041 aatgaactgt ctacagaatc ctggttcctc ttgcctgctt aaaaactggg atcccgactc
     2101 catggatcaa aactgagtga caaggccagc cctctaccag aatgactcag tttcctcttt
     2161 cctagttagt gacagtatga agaacatgct gccacagaag gtggaggtgc tctcttcaaa
     2221 agagagtgaa tggacggggg agagcgcgag ctggaatagc agaatccatt ctgactctta
     2281 gtcatgctag aatttgggaa cagaaacagc gttttattgc tttgtttctt tctcttgttc
     2341 cccacacagt gtgtcaacag ctaattccag tattgttgtc acaggcgtaa ataatattta
     2401 tcagcagttt tgagcaaatg attttctatt tctatcttga aaaacaaaaa aggcagaatt
     2461 gccatattct caggttatgg cctaggagtg tcattacggg tacaaggtgc agttcctggt
     2521 gaatataaca tgttaagact gctaggcaga catattggct ttatcccatg ggattcagtg
     2581 gctgccgaag tattcttgaa cattgtgttc tgtgtcctgg cactgaagcc agcatgagat
     2641 ccatcattct tatgtcagct caagggtcaa aaggacttaa aaaaaaatca gaatcctgtg
     2701 gcctatcaca tggcaaaagt tatcctaaat ctttttttta attagaaaat ccctaaatct
     2761 aaaattaatg ttatatctgc agcccactta ttttcaaaat gagaaattaa taatcagtgt
     2821 gaaatcctga gtatttaacg gtagctggtt ttaagacatg gtactatcag aagaatagaa
     2881 agtgaagaga gagtttagat atttgatccc c
//