From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens mRNA for FLT4, class III receptor tyrosine kinase.
Date: 21 Dec 92 20:28:38 GMT
Distribution: bionet
Checksum: 48850 9

LOCUS       HUMFLT4      4416 bp ss-RNA             PRI       18-NOV-1992
DEFINITION  H.sapiens mRNA for FLT4, class III receptor tyrosine kinase.
ACCESSION   X68203
KEYWORDS    FLT4; tyrosine kinase receptor.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Aprelikova,O., Pajusola,K., Partanen,J.M., Alitalo,R., Bailey,S.K.,
            McMahon,J., Wasmuth,J., Huebner,K. and Alitalo,K.
  TITLE     FLT4, a Novel Class III Receptor Tyrosine Kinase in Chromosome
            5q33-qter
  JOURNAL   Cancer Res. 52, 746-748 (1992)
  STANDARD  full automatic
COMMENT     *source: haplotype=erythroleukemia cells; *source: cell_line=HEL;
            *source: chromosome=5q35;
               Related sequence: X51602
               From EMBL    entry HSFLT4;  dated 28-SEP-1992.
FEATURES             Location/Qualifiers
     mRNA            <1..>4416
                     /gene="FTL4"
     CDS             <1..3916
                     /partial
                     /note="class III tyrosine kinase"
                     /product="FTL4"
                     /codon_start=2
                     /translation="HAQRPEMQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEES
                     HVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVL
                     LLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAM
                     WVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGD
                     QDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPG
                     KQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVH
                     ENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVL
                     KEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALT
                     CTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIE
                     SLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTI
                     ESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFAT
                     PLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALE
                     APRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLS
                     IQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVL
                     LLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRV
                     LGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLN
                     VVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVEL
                     ARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARG
                     MEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMA
                     PESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA
                     TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGS
                     FSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFE
                     EFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFR"
BASE COUNT      941 a   1345 c   1355 g    774 t      1 others
ORIGIN      
        1 ccacgcgcag cggccggaga tgcagcgggg cgccgcgctg tgcctgcgac tgtggctctg
       61 cctgggactc ctggacggcc tggtgagtgg ctactccatg acccccccga ccttgaacat
      121 cacggaggag tcacacgtca tcgacaccgg tgacagcctg tccatctcct gcaggggaca
      181 gcaccccctc gagtgggctt ggccaggagc tcaggaggcg ccagccaccg gagacaagga
      241 cagcgaggac acgggggtgg tgcgagactg cgagggcaca gacgccaggc cctactgcaa
      301 ggtgttgctg ctgcacgagg tacatgccaa cgacacaggc agctacgtct gctactacaa
      361 gtacatcaag gcacgcatcg agggcaccac ggccgccagc tcctacgtgt tcgtgagaga
      421 ctttgagcag ccattcatca acaagcctga cacgctcttg gtcaacagga aggacgccat
      481 gtgggtgccc tgtctggtgt ccatccccgg cctcaatgtc acgctgcgct cgcaaagctc
      541 ggtgctgtgg ccagacgggc aggaggtggt gtgggatgac cggcggggca tgctcgtgtc
      601 cacgccactg ctgcacgatg ccctgtacct gcagtgcgag accacctggg gagaccagga
      661 cttcctttcc aaccccttcc tggtgcacat cacaggcaac gagctctatg acatccagct
      721 gttgcccagg aagtcgctgg agctgctggt aggggagaag ctggtcctga actgcaccgt
      781 gtgggctgag tttaactcag gtgtcacctt tgactgggac tacccaggga agcaggcaga
      841 gcggggtaag tgggtgcccg agcgacgctc ccagcagacc cacacagaac tctccagcat
      901 cctgaccatc cacaacgtca gccagcacga cctgggctcg tatgtgtgca aggccaacaa
      961 cggcatccag cgatttcggg agagcaccga ggtcattgtg catgaaaatc ccttcatcag
     1021 cgtcgagtgg ctcaaaggac ccatcctgga ggccacggca ggagacgagc tggtgaagct
     1081 gcccgtgaag ctggcagcgt accccccgcc cgagttccag tggtacaagg atggaaaggc
     1141 actgtccggg cgccacagtc cacatgccct ggtgctcaag gaggtgacag aggccagcac
     1201 aggcacctac accctcgccc tgtggaactc cgctgctggc ctgaggcgca acatcagcct
     1261 ggagctggtg gtgaatgtgc ccccccagat acatgagaag gaggcctcct cccccagcat
     1321 ctactcgcgt cacagccgcc aggccctcac ctgcacggcc tacggggtgc ccctgcctct
     1381 cagcatccag tggcactggc ggccctggac accctgcaag atgtttgccc agcgtagtct
     1441 ccggcggcgg cagcagcaag acctcatgcc acagtgccgt gactggaggg cggtgaccac
     1501 gcaggatgcc gtgaacccca tcgagagcct ggacacctgg accgagtttg tggagggaaa
     1561 gaataagact gtgagcaagc tggtgatcca gaatgccaac gtgtctgcca tgtacaagtg
     1621 tgtggtctcc aacaaggtgg gccaggatga gcggctcatc tacttctatg tgaccaccat
     1681 ccccgacggc ttcaccatcg aatccaagcc atccgaggag ctactagagg gccagccggt
     1741 gctcctgagc tgccaagccg acagctacaa gtacgagcat ctgcgctggt accgcctcaa
     1801 cctgtccacg ctgcacgatg cgcacgggaa cccgcttctg ctcgactgca agaacgtgca
     1861 tctgttcgcc acccctctgg ccgccagcct ggaggaggtg gcacctgggg cgcgccacgc
     1921 cacgctcagc ctgagtatcc cccgcgtcgc gcccgagcac gagggccact atgtgtgcga
     1981 agtgcaagac cggcgcagcc atgacaagca ctgccacaag aagtacctgt cggtgcaggc
     2041 cctggaagcc cctcggctca cgcagaactt gaccgacctc ctggtgaacg tgagcgactc
     2101 gctggagatg cagtgcttgg tggccggagc gcacgcgccc agcatcgtgt ggtacaaaga
     2161 cgagaggctg ctggaggaaa agtctggagt cgacttggcg gactccaacc agaagctgag
     2221 catccagcgc gtgcgcgagg aggatgcggg acgctatctg tgcagcgtgt gcaacgccaa
     2281 gggctgcgtc aactcctccg ccagcgtggc cgtggaaggc tccgaggata agggcagcat
     2341 ggagatcgtg atccttgtcg gtaccggcgt catcgctgtc ttcttctggg tcctcctcct
     2401 cctcatcttc tgtaacatga ggaggccggc ccacgcagac atcaagacgg gctacctgtc
     2461 catcatcatg gaccccgggg aggtgcctct ggaggagcaa tgcgaatacc tgtcctacga
     2521 tgccagccag tgggaattcc cccgagagcg gctgcacctg gggagagtgc tcggctacgg
     2581 cgccttcggg aaggtggtgg aagcctccgc tttcggcatc cacaagggca gcagctgtga
     2641 caccgtggcc gtgaaaatgc tgaaagaggg cgccacggcc agcgagcacc gcgcgctgat
     2701 gtcggagctc aagatcctca ttcacatcgg caaccacctc aacgtggtca acctcctcgg
     2761 ggcgtgcacc aagccgcagg gccccctcat ggtgatcgtg gagttctgca agtacggcaa
     2821 cctctccaac ttcctgcgcg ccaagcggga cgccttcagc ccctgcgcgg agaagtctcc
     2881 cgagcagcgc ggacgcttcc gcgccatggt ggagctcgcc aggctggatc ggaggcggcc
     2941 ggggagcagc gacagggtcc tcttcgcgcg gttctcgaag accgagggcg gagcgaggcg
     3001 ggcttctcca gaccaagaag ctgaggacct gtggctgagc ccgctgacca tggaagatct
     3061 tgtctgctac agcttccagg tggccagagg gatggagttc ctggcttccc gaaagtgcat
     3121 ccacagagac ctggctgctc ggaacattct gctgtcggaa agcgacgtgg tgaagatctg
     3181 tgactttggc cttgcccggg acatctacaa agaccctgac tacgtccgca agggcagtgc
     3241 ccggctgccc ctgaagtgga tggcccctga aagcatcttc gacaaggtgt acaccacgca
     3301 gagtgacgtg tggtcctttg gggtgcttct ctgggagatc ttctctctgg gggcctcccc
     3361 gtaccctggg gtgcagatca atgaggagtt ctgccagcgg ctgagagacg gcacaaggat
     3421 gagggccccg gagctggcca ctcccgccat acgccgcatc atgctgaact gctggtccgg
     3481 agaccccaag gcgagacctg cattctcgga gctggtggag atcctggggg acctgctcca
     3541 gggcaggggc ctgcaagagg aagaggaggt ctgcatggcc ccgcgcagct ctcagagctc
     3601 agaagagggc agcttctcgc aggtgtccac catggcccta cacatcgccc aggctgacgc
     3661 tgaggacagc ccgccaagcc tgcagcgcca cagcctggcc gccaggtatt acaactgggt
     3721 gtcctttccc gggtgcctgg ccagaggggc tgagacccgt ggttcctcca ggatgaagac
     3781 atttgaggaa ttccccatga ccccaacgac ctacaaaggc tctgtggaca accagacaga
     3841 cagtgggatg gtgctggcct cggaggagtt tgagcagata gagagcaggc atagacaaga
     3901 aagcggcttc aggtagctga agcagagaga gagaaggcag catacgtcag cattttcttc
     3961 tctgcactta taagaaagat caaagacttt aagactttcg ctatttcttc tactgctatc
     4021 tactacaaac ttcaaagagg aaccaggagg acaagaggag catgaaagtg gacaaggagt
     4081 gtgaccactg aagcaccaca gggaaggggt taggcctccg gatgactgcg ggcaggcctg
     4141 gataatatcc agcctcccac aagaagctgg tggagcagag tgttccctga ctcctccaag
     4201 gaaagggaga cgccctttca tggtctgctg agtaacaggt gcnttcccag acactggcgt
     4261 tactgcttga ccaaagagcc ctcaagcggc ccttatgcca gcgtgacaga gggctcacct
     4321 cttgccttct aggtcacttc tcacacaatg tcccttcagc acctgaccct gtgcccgcca
     4381 gttattcctt ggtaatatga gtaatacatc aaagag
//