From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human MHC class I HLA-B*4005 mRNA, complete cds.
Date: 29 Dec 92 01:19:41 GMT
Distribution: bionet
Checksum: 10580 4

LOCUS       HUMMHHLAB4   1089 bp ss-mRNA            PRI       07-DEC-1992
DEFINITION  Human MHC class I HLA-B*4005 mRNA, complete cds.
ACCESSION   M84694
KEYWORDS    cell surface antigen; cell surface glycoprotein; class I gene;
            integral membrane protein; major histocompatibility complex.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Hildebrand,W.H., Madrigal,J.A. and Parham,P.
  TITLE     Serologic cross-reactivities poorly reflect allelic relationships
            in the HLA-B12 and HLA-B21 groups: Dominant epitopes of the alpha-2
            helix
  JOURNAL   J. Immunol. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            1..73
                     /number=1
                     /gene="HLA-B"
     sig_peptide     1..72
                     /gene="HLA-B"
                     /codon_start=1
     mat_peptide     73..1086
                     /product="lymphocyte antigen"
                     /gene="HLA-B"
                     /codon_start=1
     exon            74..343
                     /number=2
                     /gene="HLA-B"
     exon            344..619
                     /number=3
                     /gene="HLA-B"
     exon            620..895
                     /number=4
                     /gene="HLA-B"
     exon            896..1012
                     /number=5
                     /gene="HLA-B"
     exon            1013..1089
                     /number=6-8
                     /gene="HLA-B"
     CDS             1..1089
                     /gene="HLA-B"
                     /note="presents processed antigens to cytotoxic T cells"
                     /product="lymphocyte antigen"
                     /codon_start=1
                     /translation="MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEP
                     RFITVGYVDDTLFVRFDSDATSPRKEPRAPWIEQEGPEYWDRETQISKTNTQTYRESL
                     RNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAA
                     DTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPI
                     SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSG
                     EEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRR
                     KSSGGKGGSYSQAACSDSAQGSDVSLTA"
BASE COUNT      220 a    336 c    362 g    171 t
ORIGIN      
        1 atgcgggtca cggcgccccg aaccctcctc ctgctgctct ggggggcagt ggccctgacc
       61 gagacctggg ctggctccca ctccatgagg tatttccaca cctccgtgtc ccggcccggc
      121 cgcggggagc cccgcttcat caccgtgggc tacgtggacg acacgctgtt cgtgaggttc
      181 gacagcgacg ccacgagtcc gaggaaggag ccgcgggcgc catggataga gcaggagggg
      241 ccggagtatt gggaccggga gacacagatc tccaagacca acacacagac ttaccgagag
      301 agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca caccctccag
      361 agcatgtacg gctgcgacgt ggggccggac gggcgcctcc tccgcgggca taaccagtac
      421 gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcctg gaccgccgcg
      481 gacacggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgaggc ggagcagctg
      541 agagcctacc tggagggcct gtgcgtggag tggctccgca gatacctgga gaacgggaag
      601 gagacgctgc agcgcgcgga ccccccaaag acacacgtga cccaccaccc catctctgac
      661 catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc
      721 tggcagcggg atggcgagga ccaaactcag gacactgagc ttgtggagac cagaccagca
      781 ggagatagaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga
      841 tacacatgcc atgtacagca tgaggggctg ccgaagcccc tcaccctgag atgggagccg
      901 tcttcccagt ccaccgtccc catcgtgggc attgttgctg gcctggctgt cctagcagtt
      961 gtggtcatcg gagctgtggt cgctgctgtg atgtgtagga ggaagagctc aggtggaaaa
     1021 ggagggagct actctcaggc tgcgtgcagc gacagtgccc agggctctga tgtgtctctc
     1081 acagcttga
//