From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Asian cobra complement component C3 mRNA, complete cds.
Date: 26 Jan 93 05:49:00 GMT
Distribution: bionet
Checksum: 54940 11

LOCUS       NAJCOMPC3X   5211 bp ss-mRNA            VRT       25-JAN-1993
DEFINITION  Asian cobra complement component C3 mRNA, complete cds.
ACCESSION   L02365
KEYWORDS    complement component C3.
SOURCE      Naja naja (strain Kaouthia) liver cDNA to mRNA.
  ORGANISM  Naja naja
            Eukaryota; Animalia; Chordata; Vertebrata; Reptilia; Lepidosauria;
            Squamata; Serpentes; Colubroidea; Elapidae; Elapinae.
REFERENCE   1  (bases 1 to 5211)
  AUTHORS   Fritzinger,D.C., Connelly,M., Petrella,E.C., Bredehorst,R. and
            Vogel,C.-W.
  TITLE     Primary structure of cobra complement component C3
  JOURNAL   J. Immunol. 149, 3554-3562 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     sig_peptide     9..74
                     /codon_start=1
     mat_peptide     75..1973
                     /product="complement component C3 beta chain"
                     /codon_start=1
     misc_feature    1974..1985
                     /standard_name="interchain region"
     misc_feature    1986..2222
                     /standard_name="C3a peptide"
     mat_peptide     1986..4961
                     /product="complement component C3 alpha chain"
                     /codon_start=1
     misc_feature    2222^2223
                     /note="C3 convertase cleavage site"
     misc_feature    2982..3059
                     /function="thioester site"
     misc_binding    3594..3792
                     /bound_moiety="complement factor H"
     misc_binding    3630..3665
                     /bound_moiety="complement receptor 2 (CR2)"
     misc_binding    4242..4334
                     /bound_moiety="properdin"
     polyA_signal    5189..5194
     polyA_site      5205
     CDS             9..4964
                     /product="complement component C3"
                     /codon_start=1
                     /translation="MEGMALYLVAALLIGFPGSSHGALYTLITPAVLRTDTEEQILVE
                     AHGDSTPKSLDIFVHDFPRKQKTLFQSRVDMNQAGSMFVTPTIKVPAKELNKDSKQNQ
                     YVVVKVTGPQVALEKVVLLSYQSGFVFIQTDKGIYTPGSPVRYRVFSVDHNMHRMDKT
                     VIVEFQTPEGIVVSSKPVNPSGSIRPYNLPELVSFGTWKAVAKYEHSPEESYTAYFDV
                     REYVLPSFEVRLQPSDKFLYIDGNKNFHVSITARYLYGKKVEGVAFVVFGVKIDDAKK
                     SIPDSLTRIPIIDGDGEATLKRDTLRSRFQDLNQLVGHTLYVSVTVITESGSDMVVTE
                     QGGIHIVTSPYQIYFTKTPKYFKPGMPYELTVYVTNPDGSPAAHVPVVSEAIHSEGTT
                     LSDGTAKLILNTPLNIQSLPITVRTNHGDLPRERQAIKSMTATAYQTQGGSENYLHVA
                     ITSTEIKPGDNLPVNFNVRGNANSLNQIKYFTYLILNKGKIFKVGRQPRRDGQNLVTM
                     NLHITPDLIPSFRFVAYYQVGNNEIVADSVWVDVKDTCMGTLVVKGASSRDDRIQKPG
                     AAMKIKLEGDPGARVGLVAVDKAVYVLNDKYKISQAKIWDTIEKSDFGCTAGSGQNNL
                     GVFEDAGLALTTSTNLNTKQRSAAKCPQPANRRRRSSVLLLDSKASKAAQFQDQGLRK
                     CCEDGMHENPMGYTCEKRAKYIQEGDACKAAFLECCHYIKGIRDENQRESELFLARSD
                     FEDELFGDDNIISRSDFPESWLWLTEELTGEPNNQGISSKTVPFYLRDSITTWELLAV
                     GLSPTKGICVAEPYEITVMKDFFIDLRLPYSVVKNEQVEIRAILYNYADEDIYVRVEL
                     IYNPAFCSASTEGQRYRQQFPIKALSSRAVPFVIVPLEQGLHDVEVIASVRGELASDG
                     VRKKLKVVPEGERKNIVTIIELDPSVKGVGGTQELTVIANKLDDKVPDTEVETRISVL
                     GDPVAQIIENSIDGSKLNHLIITPSGCGEQNMITMTPSVIATYYLDATGQWENLGVDR
                     RTEAIKQIMTGYAQQMVYKKADHSYAAFTNRASSSWLTAYVVKVLAMASNMVKDISHE
                     IICGGVKWLILNRQQPDGVFKENAPVIHGEMLGGTKGAEPEASLTAFIVTALLESRSV
                     CKEQINILDSSINKATDYLLKKYEKLQRPYTTALTAYALAAADRLNDDRVLMAASTGR
                     NRWEEYNARTHNIEGTSYALLALLKMKKFAEVGPVVRWLIDQKYYGGTYGQTQATVMV
                     FQALAEYEIQMPTHQDLNLDISIKLPEREVPERYSINDRNAVQARTVETKLNEDFTVS
                     ASGDGKATMTILTVYNAQLREDANVCNKFHLDVSVENVELNLKQAKGGKAALRLKICT
                     RYLGEVDSTMTIIDISMLTGFFPDAEDLKRLSNGVDRYISKFEIDNNMAQKGTVVIYL
                     DKVSHSEDECLHFKIHKHFEVGFIQPGSVKVYSYYNLDEQCTKFYHPDKETGLLNKIC
                     HGNICRCAEETCSLLNQQKKIDLQLRIQKACAQNVDYVYKTKLLRIEEKDGNDIYFMD
                     VLEVIKGGTDRNAQAKARQYVSQRKCQEALNLKLDNDYLIWGLSSDLWPMKDDISYLI
                     TKNTWIERWPNEDECQDEEFQNLCDDFAQLSNTLTIFGCPT"
BASE COUNT     1612 a   1042 c   1201 g   1356 t
ORIGIN      
        1 ggactaccat ggaggggatg gctctctatc tggtggctgc tctattgatt ggttttccag
       61 ggtcttccca cggggctctc tataccctca tcacccctgc tgttttgcga acagacacag
      121 aagagcaaat tttggtggag gcccatggag acagtactcc aaaatcgctt gacatctttg
      181 ttcatgattt tccacggaag cagaaaacct tgttccaaag cagagtagat atgaatcagg
      241 caggaagcat gtttgtcact ccaactataa aggttcctgc aaaagaactg aataaggact
      301 ccaagcaaaa tcagtatgtg gttgtgaaag taactggtcc tcaagtggca ttggaaaagg
      361 tggttctcct ttcttaccag agtggctttg tgttcatcca gacagataaa ggcatctata
      421 caccaggctc tccagtgcgt tatcgtgtct tttctgtgga tcacaacatg cacaggatgg
      481 acaaaactgt gattgtcgag tttcagactc cagaaggcat tgttgtcagt tctaaaccag
      541 tcaatccatc aggctcgatc cggccttaca atttaccaga gcttgtcagt tttgggacat
      601 ggaaggctgt ggccaaatat gaacattcac cagaagagag ctacactgca tattttgatg
      661 tcagagaata tgtgttacca agctttgaag tccgtctgca accatcagat aagtttcttt
      721 acattgatgg gaataaaaat ttccacgtgt ctatcactgc aaggtactta tatggaaaga
      781 aagtggaagg tgtggccttt gtcgtctttg gagtcaaaat agatgatgct aaaaagagta
      841 ttccagactc actcacgaga attccgatta ttgatggaga tggggaagca acactaaaaa
      901 gagatacact acgttcccga tttcaagatc tcaatcagct tgttggtcat actctgtatg
      961 tatctgtaac agtgataaca gaatcaggca gtgatatggt agtgactgag caaggcggca
     1021 ttcatattgt gacatctccc tatcagatct acttcacaaa aacccccaaa tatttcaagc
     1081 caggaatgcc atatgaactg acggtgtatg ttaccaaccc tgatggctca ccagctgccc
     1141 atgtgccagt ggtatcagag gccattcatt ctgagggaac cactttgagt gatgggactg
     1201 ctaagctcat tctgaacaca ccactgaaca ttcaaagcct accgatcact gttagaacta
     1261 accatggaga cctcccaaga gaacgccagg caataaagtc catgacagcc acagcctacc
     1321 aaacccaggg agggtctgaa aactatcttc atgtagccat tacatctaca gagattaagc
     1381 ccggagataa cttacctgtc aatttcaatg tgaggggcaa tgcaaattca ctgaaccaga
     1441 tcaaatattt cacatacctc atattgaata aagggaagat tttcaaggtt ggcaggcaac
     1501 ccaggagaga tgggcagaat ctggtgacca tgaatctgca tatcactcca gatctcatcc
     1561 cttccttccg gtttgtggct tactaccaag tgggaaataa cgaaattgtg gctgattctg
     1621 tctgggtgga tgtgaaggat acctgcatgg gaacgttggt tgtgaaagga gcgtcttcca
     1681 gagacgatcg aatacaaaag ccaggagctg caatgaaaat caaattggaa ggggatccag
     1741 gtgctcgggt tggtcttgtg gctgtggaca aagcagtata tgttctcaat gataaatata
     1801 agattagcca agctaagata tgggacacaa tagaaaagag tgactttggc tgtacagctg
     1861 gcagtggcca gaataatctg ggtgtgtttg aagatgctgg actggctctg acaaccagca
     1921 ctaatctcaa caccaaacag agatcagctg caaagtgtcc tcagcctgca aatcggaggc
     1981 gtcgcagttc tgttttgctg cttgacagca aagcaagcaa agcggcacag tttcaggatc
     2041 aaggcctgcg taaatgctgt gaagatggca tgcatgagaa ccccatgggg tacacttgtg
     2101 aaaagcgtgc aaaatacatc caggagggag atgcttgtaa ggctgccttc cttgaatgtt
     2161 gtcactacat caaagggatc cgagatgaaa accaacggga gagcgagttg tttctggcaa
     2221 gaagtgattt tgaagatgaa ctctttggag atgacaacat catctccagg tctgattttc
     2281 ccgagagttg gttgtggcta acagaggaat tgaccgggga gcctaacaat caagggattt
     2341 caagcaagac agtacctttt tatctgaggg attccatcac aacctgggag ttgctggctg
     2401 tgggcctttc acccaccaaa gggatctgtg tggctgaacc gtatgaaata acagtcatga
     2461 aagacttctt cattgatctt cgactgccat attcagtagt gaagaatgag caggtggaga
     2521 ttcgagctat tctgtacaac tacgctgacg aggatattta tgtgcgagtg gaactgatat
     2581 acaacccagc cttctgcagt gcttccacag aaggacaaag ataccgacag cagttcccaa
     2641 ttaaagccct gtcctccaga gcagtaccat ttgtgatagt cccattagag caaggattgc
     2701 atgatgttga ggttatagca agtgtccggg gagagttggc atcagatggt gtgaggaaga
     2761 aactgaaagt tgtacctgaa ggggaacgga aaaatattgt gactattatt gaactggacc
     2821 caagtgtaaa aggagttggt ggaacccagg aactaacggt catagccaat aaattagatg
     2881 acaaggtgcc tgatacagaa gttgagacca ggatttctgt tctaggtgac cctgtggctc
     2941 agattattga aaactcaatt gatggaagta aactcaatca tctcattatt actccttctg
     3001 gctgtgggga gcaaaatatg atcaccatga ctccatcggt cattgccacc tactacttgg
     3061 acgcaacagg gcagtgggag aatcttggtg tggatcgcag gactgaagct atcaaacaga
     3121 tcatgactgg ttatgcccag cagatggtgt acaagaaagc agatcattcc tatgcagcat
     3181 ttacaaaccg tgcatctagt tcttggctaa cagcatatgt ggtgaaagtc ttagccatgg
     3241 cttccaacat ggtaaaagac attagccatg aaattatttg tggaggtgtg aaatggctca
     3301 ttctgaacag gcaacaacca gatggagtgt tcaaagaaaa tgcccctgtg atccatggag
     3361 aaatgctggg aggaactaaa ggtgctgaac cagaagcatc tttaacagca ttcattgtga
     3421 ctgcattatt ggaatccaga tcagtctgca aagaacaaat caatattcta gacagcagca
     3481 tcaataaggc cacagattat ttactcaaaa agtatgagaa actgcaaagg ccttacacta
     3541 cagccctcac agcctatgct ttggctgctg cagaccgact caatgatgac agggtactca
     3601 tggcagcatc aacaggaagg aatcgttggg aagaatataa tgctcgcacc cataatattg
     3661 aaggcacttc ctatgccttg ttggccctgc tgaaaatgaa gaaatttgct gaggtcggtc
     3721 ctgtagtcag atggctgata gatcagaaat attatggggg aacatatgga caaacccaag
     3781 caacagttat ggtgtttcaa gctcttgctg aatatgagat tcagatgcct acccatcagg
     3841 acttaaattt agatatttct attaaactgc cagaacgaga agtacctgaa aggtacagca
     3901 ttaatgatag aaatgctgtc caggcccgga cagtagagac caaactcaac gaagacttca
     3961 ctgtgtcagc atcaggtgat ggaaaagcaa caatgaccat tttgacggtc tataatgcac
     4021 aattgaggga ggatgcaaat gtttgcaaca aattccatct tgatgtttct gttgaaaacg
     4081 tcgaattgaa cttaaaacag gcaaagggag gcaaggcagc cctcaggctt aaaatctgca
     4141 ctaggtatct gggagaagtt gattctacaa tgacaataat tgatatttct atgctgactg
     4201 gttttttccc tgatgctgaa gaccttaaaa ggctttctaa cggagtggac agatacatct
     4261 ccaagtttga aattgacaat aatatggctc agaaaggaac tgttgtcatt tacttagaca
     4321 aggtctccca ctctgaagat gaatgcctgc actttaagat tcacaagcat tttgaagttg
     4381 gcttcattca gccaggatca gtcaaggtgt acagctacta caatctagat gaacaatgta
     4441 ccaagttcta ccatccagat aaagaaacag gtcttctcaa taagatatgt catggtaaca
     4501 tttgccgatg tgcagaagaa acctgttcct tgctcaacca gcagaaaaag attgatcttc
     4561 aattacgaat tcaaaaagcc tgcgcgcaaa atgtggatta tgtctacaaa accaagctgc
     4621 ttcgaataga agaaaaagat ggtaatgata tctatttcat ggatgtttta gaagttatta
     4681 aaggaggcac tgaccgaaat gcacaagcaa aagcccgcca gtatgtaagt caaaggaaat
     4741 gccaggaggc tttgaatctg aagctggata atgattatct gatctggggt ctcagcagtg
     4801 acctgtggcc catgaaagat gatatctcct acctcattac aaagaacacc tggattgaga
     4861 gatggccaaa tgaagatgaa tgccaggatg aagaattcca gaatttgtgt gatgactttg
     4921 ctcagttgtc caatacactg actatttttg gctgccctac ttaaaagttc agaagaatca
     4981 atgataggaa gaaaattctc agaagacaga tttttgagcc aatacatata tgttactttg
     5041 cctcttgatt tttttttagt tttttatcat tttgctctgc tgttttcctt cacaattgtt
     5101 tatacagaaa ataaataatt gatttcttac tttgaaaaaa tggaactctc tgatttgggt
     5161 tttccagatg tgccaaaatg acaactctaa taaatgactt gaggaaaaaa a
//