From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human type II procollagen gene exon 1
Date: 4 Sep 92 10:04:24 GMT
Distribution: bionet
Checksum: 61116    10

LOCUS       HUMPROCOE1   5887 bp ds-DNA             PRI       04-SEP-1992
DEFINITION  Human type II procollagen gene exon 1
ACCESSION   X58709
KEYWORDS    extracellular matrix protein; procollagen gene type II.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5887)
  AUTHORS   Vikkula,M., Metsaeranta,M., Syvaenen,A.C., Ala-Kokko,L., Vuorio,E.
            and Peltonen,L.
  TITLE     Structural analysis of the regulatory elements of the type-II
            procollagen gene. Conservation of promoter and first intron
            sequences between human and mouse
  JOURNAL   Biochem. J. 285, 287-294 (1992)
  STANDARD  full automatic
COMMENT     *source: clone=2, 15, 17, 20, 22, 48, 88, 94; *source: isolate=
            OA-patient; *source: chromosome=12;
            From EMBL    entry HSPROCOE1;  dated 31-JUL-1992.
FEATURES             Location/Qualifiers
     misc_feature    1190..1196
                     /note="CCCTYCC-binding sequence"
     misc_feature    1238..1244
                     /note="CCCTYCC-binding sequence"
     misc_binding    complement(1243..1248)
                     /bound_moiety="Sp1"
     misc_binding    complement(1309..1314)
                     /bound_moiety="Sp1"
     misc_binding    1346..1351
                     /bound_moiety="Sp1"
     misc_binding    1425..1430
                     /bound_moiety="Sp1"
     misc_binding    1429..1434
                     /bound_moiety="Sp1"
     misc_binding    1463..1468
                     /bound_moiety="Sp1"
     enhancer        1472..1479
                     /note="viral core enhancer"
     TATA_signal     1514..1519
     exon            1698..1782
                     /note="type II procollagen gene exon 1"
     misc_feature    2411..2416
                     /note="LF-A1 motif"
     misc_feature    3587
                     /note="polymorphism (G/A)"
     misc_feature    3616..3621
                     /note="ATF motif"
     misc_feature    3734..3739
                     /note="LF-A1 motif"
     misc_feature    3804..3809
                     /note="b-interferon silencer B"
     misc_feature    4116..4121
                     /note="b-interferon silencer B"
     misc_feature    4254..4259
                     /note="b-interferon silencer B"
     misc_feature    4973
                     /note="polymorphism (C/A)"
BASE COUNT     1139 a   1763 c   1600 g   1385 t
ORIGIN
        1 cttccccatc tccatccaga ctggacaaag cctagaagca tttccttcaa caatgagttc
       61 tttccctttc caaccagagc acttggaact ccagcctcta ccaggacaag tgtcaaagca
      121 tgataggcta gggatggggt cccaggaccc tggtggaagc ctaaggccca gaagtagctt
      181 ctttcaagtg ctctcagctt ctagggggaa agctccagag aaacaaaact gcccaggagg
      241 gcagaagttc tggttaagtc agaccccaaa ttctgagttt cattttgcct atagttcttt
      301 gggggaccat atcgctcaaa aggaaggtct gtttggggac gtttcctccc tggtatgaaa
      361 ggaggcaccg gagaccaaga gaagagacca gctaagccct ggggagaagg cagtttggct
      421 aaggtgagag agggcgctca ccggggaagg tgaggtgagg cggcaagcgg agggctaggg
      481 ggccgactgg gaaattctgg cgcttctccc cggctcacag aactcgccag ctggatcggc
      541 ctccccgatc cctgccaggg ccgcagcagt gaccaaccgt ccctggccaa agctgctcta
      601 cgacggccgg cagtgcccac tccccggggg actcccggac cccagccagg aagagcagac
      661 accacgtctg agcctggagc tagacagtcc ccccacagca ggcagcttgc accgtttagt
      721 ctcggctccc tccgtcctct gtggctcttt cagtcccctt cccagggcct gcccctgccc
      781 cccacacctt cacacaggtc tccttctgtg cagtaacaca ccagctcttt tcctggctgt
      841 cggctcagcc aacttcggcc tgtgctccag aggaagcctt caacgcagag ctggatgggg
      901 gaggggtgga gggcagtcgc tgtgaacgtc caggtgggag tctggggacc aggtactgca
      961 gggaagggct aaaagatagg tcggggtaac ccttcagatc tggctcagct agcctgtctc
     1021 caagatttag gactctgaat ctctgtgggc tcctccctgt ccccactccc aaacgcctga
     1081 cgcggtgccc cctcgccctc cgctgctcct ttctaccgct ttccctcctc cctcccatgt
     1141 cttttccgtc cttggtctag ggctctcggc ctgcgcctct gcaaacaccc cctcccctcc
     1201 aactccggca gaactccgag gggaggggcc ggacgagccc ttcccgcctg tggtcagagg
     1261 ggggcagcgc gcagccccgg gtttgggggg caggggccat ctctgcgccc cgcccgatca
     1321 ggccactcgg cgcactaggg gtggagggcg ggaagcgtga ctcccagaga ggggggtccg
     1381 gcttgggcag gtgcgggcac tggcagggcc caggcgggct ccgggggcgg gcggttcagg
     1441 ttacagccca gctgggggca gggggcggcc cgcggtttgg gcgagttcgc cagcctcgaa
     1501 aggggccggg cgcatataac gggcgccgcg gcggggagaa gacgcagagc gctgctgggc
     1561 tgccgggtct cccgcttcct cctcctgctc caagggcctc ctgcatgagg gcgcggtaga
     1621 gacccggacc cgcgccgtgc tcctgccgtt tcgctgcgct ccgcccggcc cggctcagcc
     1681 aggccccgcg gtgagccatg attcgcctcg gggctcccca gtcgctggtg ctgctgacgc
     1741 tgctcgtcgc cgctgtcctt cggtgtcagg gccaggatgt ccgtaagtct tcccccgccg
     1801 ctgcctgcct gcctgctttc catgcgtccc tcagcatcct tctccccggc ccgctccagc
     1861 tctggagccc gcggctccgg gctaaaacgg ctcccggggt cgtagcgcgc cgacttaggc
     1921 acaggacacg cagaagttca ccaagaagag ttctgccaat caagactctg tcccagggtc
     1981 ctcggtgccc atcgcagttg caagtatttg caggtcccta cgttgcgcta gaatactgaa
     2041 cttgcaaagt gttggctcgg agaagtttgc gcacagatat aaatgggctc ttttccacca
     2101 gctttgataa ttaggcgcac atgcacacag ctcgcctctt cgaagcactt cgagttcagc
     2161 aaaaacagat ctcaactcat cgaacttagg tgaagtagga aagagagagc gcgacgggga
     2221 gcaagcaaac gccaaagggt tgacttcaca gcctgtccaa ggcttggtgg ctggtgggct
     2281 caaagcagag ttagacaaag gggactaaca ctctgacact ggtgggctga aatcccaggc
     2341 cacaaagaac ggcttccgat aggccctctg agacctcagc gcctctttag ggtaccctcc
     2401 ccctcccagc tggccctgga gcaaggtgca gccctagcgc tcatctcgac ttccctccgt
     2461 ccgcctgcgc ctctcttctg ataaagggta cagaaacttc cagtaggaga ggccatctga
     2521 aagacgataa cattccaacc agaccgtgct tttcaaatgc ccccgaaaat agcgccccct
     2581 tccccgcggt cttaccccat tccccgccgc cccgaggtac tacaatgagt tacttttcta
     2641 aattctggaa ctcaccgagc caggctgcgt ggtgtgtgtg tgtgtgcgtg tgtgtgtgtg
     2701 tatgtgtgtg tcagggaagg ggagcaggct ggtcgattgc tacggttgct acaactattt
     2761 caaccggtat agttagagat ggctcttgta gtcgggtcca aatgctgttc ggactgcacc
     2821 tttctacccc tcctttggta aggtccactg tctgggatta tattcaggac aaacgaagcc
     2881 tggaaagtgt attaggtaga gaggattttt ttttccacgt gtttgggcac gtttccgacg
     2941 gctgggattc cagccctgtc tttgtatgtt acagattgta aatcaatcgc agagggaaac
     3001 tcttcggcgg gggaaataaa agttctctgc cttcgaggct ctgtgggccc tctcctgcca
     3061 ccaggctgtt tccagggata gcgtggaagg cggcgggctc aggcgggctt tccggtcatt
     3121 agcgcagcgg gggcagggct ggagcctgcg gcgcagctgc gaggagccgg gagcaggaga
     3181 ctctggccgg gtcacccggt agtgcgctaa gctggaggcg cgctcctggg catttgagga
     3241 atacagcgtg actatacgtg gcctggactc agactgacta tatttttgta ctaaatttac
     3301 aagcacacgc ccacaaagct gtcttcttga ctgacccctg ccttagtgag caatggaatt
     3361 agctgggtgg ctttaaaata attctcaaat tctccatccg gtattagggt cgcttgctta
     3421 attaggcggt agaggtctct catcgccgca tctttcctgg gagggagtga ttccacagct
     3481 tctccggccc aaaccttcca gtcgctcctc ctcccagagg gagtgtgatt ctgcatccga
     3541 gaggctgatt ttgcgccctg gagcatccca ccttttataa cttcccccgc ctggggtcag
     3601 cggacccaaa ggtgtgacgt ggggaaatgc gcagtctgcg tggacgtcag gaatgtcaga
     3661 cacctagagc tcggccacac ccctcctctc catctttcca cgagtttgag aaacttactg
     3721 gcggcggcgt ctttgaccct catctgcatt tcagagccct cgcctccgaa agtgcccctg
     3781 gctcagggga gagatctcaa tcctcctttg tgaggcttgt ttgcattggg agattggcag
     3841 cgatggcttc cagatggggc tgaaacgctg cccgtattta tttaaactgg ttcctcgcag
     3901 agacctgtga atcgggctct gtgtgcgctc gagaaaagcc ccattcatga gagacgaggt
     3961 ccagtgggtt ctctcgtact cccagacccc ctctcccaca atgcccccct gtgcccgccc
     4021 gccgccacct ctcggctcca gccctgcgca gagcggcggt gaagcaaaac agttccccga
     4081 aagaggtagc tttttaattg gcttgccaca aagaatcact tatacggccc tgcggtaatg
     4141 aggggaaccg gatcaggcgc gccgggatgc tatcggcagc cgttttggag cagcaattat
     4201 ggtggtgctg ggctcctccg tccacaccta ggggatccgg ttacggcgct ggctcctttc
     4261 tggggcagtc atttaatccc acttttcact ctcccggtgt ctgtgagcga gccgtgtcca
     4321 gagccgcagc cacagagtca ctcagcggct cttacaccca gcgcagcctg gccccgcccc
     4381 tgcgccggcg cttcccgggc cgcccttccc cgggaaatct gatccgcacg gggagtggcc
     4441 cctctcctag catttccccc tctcctccct gggtcctcat gggcgagggt gggctctcct
     4501 gtagtctggg ctggagcgca ttaaccgatg ccccctctcc cacaccttcc tcaccgcctg
     4561 cattccactg ctccagctat tttaacggcg ggtgtgtccc cgcaacttct gtattttccc
     4621 tggaatccct caccctcctg tgattatctt gcccaaaggc taggcggatt tcttctagtg
     4681 ggaaagtaaa aaggaacgtt tatctttgga ttttcactct ctttaaagag cagtgggcag
     4741 gctcgtttct ttctccgcct ctgggtttgt ggctctttcc tattattcat cccctgctgc
     4801 tgctattgcc ttggggattt tgatgagaaa aacacgctgg gcgctcccta cgacgtggtg
     4861 cggctctaca gcccttggct gctaaggagc gctcttgtca gcacaggttt catttgcagc
     4921 atgaattcca gacggcaggg cgctggtgga ggagactagt ccctgctatt cttcctctgc
     4981 agtcttggag gaggccaggc ctggactggc aatcttagcc ctagccaggt attcaacgac
     5041 ccctgctccc caaactgggg tgctgttttc agatggaggc agggcctctc caggcagggc
     5101 tacaggtgga ggtcagcact gggggcgctt tggctccact ggcctcctaa gcagtttatt
     5161 agcctgccca agccccaagt gtattgtttg aatgggtcta tccccctccc caaattggtc
     5221 ctaattctaa tatggttcaa agaatgagac aagatcctaa ttctaatagc tcgtcttttc
     5281 accccccttt cttatatacc tatttttgga gcctcactgc ttatagattc caatttttgt
     5341 aggtagaatt ttctacattc cctctgaatg ttagttgtca gttgtattta gctaatccca
     5401 taattcccag aggaaggcag aagaaagaag acttctctgc tcctgggctg gtggaaggga
     5461 ggtctcgcca tttttctgtc tcctttcttt ttatagtccc agaattccta ttcagaatat
     5521 cttgtctcct cccttccgct caccctccaa ctccctccac ccactccatc acctggtctc
     5581 ccccgtatta ggtgggtaaa gagaatatag tatagtaacc ccccaccttc attgctgggt
     5641 caagattttc actggtgaat agacaacatg gtgcaaggtg cataataaat atttgttgaa
     5701 tacatggaaa aatcaatgat gttttaggaa aataattttt aagttctata tgtccaggtg
     5761 gccccagcct acattcttca gcatttgaat tctgtcaagt tgactgcaac ctctctcttt
     5821 ttctctctgg ctccccaccc cctccttccc ttggctctct gcttctccct ccccaccctt
     5881 ggtgcag
//