From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: M.fascicularis immunoglobulin alpha constant region gene for
Date: 28 Jul 92 10:05:54 GMT
Distribution: bionet
Checksum: 30704     7

LOCUS       MACIGACR     2955 bp ds-DNA             PRI       28-JUL-1992
DEFINITION  M.fascicularis immunoglobulin alpha constant region gene for
            alpha-immunoglobulin heavy-chain constant region
ACCESSION   X53705
KEYWORDS    direct repeat; hinge region; immunoglobulin alpha chain;
            immunoglobulin-alpha heavy-chain constant (C) region.
SOURCE      Macaca fascicularis DNA.
  ORGANISM  Macaca fascicularis
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Cercopithecidae;
            Cercopithecinae; Papionini.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Kawamura,S., Tanabe,H., Watanabe,Y., Kurosaki,K., Saitou,N.,
            Omoto,K. and Ueda,S.
  JOURNAL   Mol. Biol. Evol. 8, 793-793 (1991)
  STANDARD  simple staff_entry
COMMENT     *source: cell_type=leucocyte; *source: clone_library=genomic;
            *source: clone=ch28.MF.Ig epsillon-alpha.5; *source: is_germline=Y;
            Related sequence: X53389
            From EMBL    entry MFIGACR;  dated 29-NOV-1991.
FEATURES             Location/Qualifiers
     5'UTR           <1..290
     mRNA            join(291..590,804..1130,1341..1735)
                     /gene="immunoglobulin alpha constant region"
     CDS             join(291..590,804..1130,1341..1735)
                     /product="alpha-immunoglobulin heavy-chain constant
                     region"
                     /gene="immunoglobulin alpha constant region"
                     /codon_start=3
                     /translation="SPTRPKVFPLSLEGTQSDNVVVACLVQGFFPQEPLNVTWSKSGA
                     GVTVINFPPSQDASGGLYTTSSQLTLPAAQCPARESVTCHVEHYTNPSQDVAVPCVSE
                     TKPCLCDKPRLSLRRPALEDLLLGSEANLTCTLTGLRNPSGATFTWTPSSGKNAVQQS
                     PKRDPCGCYSVSSVLPGCAEPWNNRVTFTCTAEHPELETQLTATISKPGNTFRPEVHL
                     LPPPSEELALNELVTLTCLARGFSPEDVLVRWLKGTEQLPRDKYLTWESRKEPSQGTT
                     TFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEV
                     DGTCY"
                     /partial
     exon            291..590
                     /number=1
                     /note="CH1"
     intron          591..803
                     /number=1
     exon            804..1130
                     /number=2
                     /note="CH2"
     misc_feature    805..825
                     /note="unusual evolutional change in the hingeregion"
     intron          1131..1340
                     /number=2
     exon            1341..1735
                     /number=3
                     /note="CH3"
     polyA_signal    1760..1765
BASE COUNT      581 a    980 c    907 g    487 t
ORIGIN
        1 gagctcaggg gactcggcca ctccatagca gagccctgtt taatacaact tgtgtctggg
       61 acagcctggg tcagaggccc tatctgagga gcatgttcag aaaccgtgtc gctgggatca
      121 gacagccagg tccaaatgca ggcctgtggt gcaggagctg tgtgaccttg gggccgtcac
      181 caggcctctc tgtgctgggt tcctccagtg tagaggagag gcaggcgcag cctgttctcc
      241 tggggacatg gcatgagggc cgcgtcctca cagcgcattc tgtgttccag catccccgac
      301 cagacccaag gtcttcccgc tgagcctcga gggcacccag tcagataacg tggtcgtcgc
      361 ctgcctggtc cagggcttct tcccccagga gccactcaac gtgacctgga gcaaaagcgg
      421 agcgggcgtg accgtcataa acttcccgcc cagccaggac gcctccgggg gcctgtacac
      481 cacgagcagc cagctgaccc tgccggccgc acagtgccca gccagggagt ccgtgacatg
      541 ccacgtggag cactacacga atcccagcca ggatgtggcc gtgccctgcg gttagagggc
      601 aggctgggga gtggggcggg gccaccccag cctgccctga cactgcgcct ggacccgtgt
      661 tccccacagg gagcccccct tcactcacac cagagtggac tgtgggcaga gccccaggag
      721 gtggtggtag acaggccagg aggggcaagg cgggggcacg gggaagggcg tgctgaccag
      781 ctgaggccat ctctccactg cagtttccga aaccaagcct tgcttatgtg acaaaccccg
      841 actgtcactg cgccggccgg ccctcgagga cctgctccta ggttcagaag cgaacctcac
      901 gtgcacactg accggcctga gaaatccctc gggtgccacc ttcacctgga cgccctcaag
      961 tgggaagaac gctgtccaac agtcacctaa gcgtgacccc tgtggctgct acagtgtgtc
     1021 cagtgtcctg cccggctgtg ccgagccatg gaacaatagg gtgaccttca cctgcactgc
     1081 tgagcaccct gagttggaga cccaactaac tgccaccatc tcaaaacccg gtgggtccag
     1141 accccgctcg gggctctggt ttgcaaagca tattcccggc ctgcctcctc cctcccggtc
     1201 ctgggcttgg gtgctcatgc caagtgcaga gggaaactga ggcaggctga gggggccagg
     1261 acacagcccg gggtgtccac cagagcggta gaggctctct catcccctgc ccagcccctg
     1321 acctggctct ctacctccag gaaacacatt ccggcccgag gtccacctgc tgccgccgcc
     1381 gtcggaggag ctggccctga acgagctggt gacgctgacg tgcctggcac gcggcttcag
     1441 ccccgaggat gtgctggttc gctggctgaa gggaacagaa cagctgcccc gtgacaagta
     1501 cctgacttgg gaatcccgga aggagcccag ccagggcacc accaccttcg ccgtgaccag
     1561 catactgcgc gtggcagccg aggactggaa gaagggggac accttctcct gcatggtggg
     1621 ccacgaggcc ctgccgctgg ccttcacaca gaagaccatc gaccgcctgg cgggtaaacc
     1681 cacccacgtc aatgtgtctg tggtcatggc ggaagtggac ggcacctgct actgagccgc
     1741 ccgcctgtcc ccacccctga ataaactcca tgcttcccca agcagcccca cgcttccatc
     1801 cggcgcctct gtccatcctc agggtctcag cacgtgggaa agggccaggg cacggagagg
     1861 gaagaacacc cctgccctga gcctcgtggg gccctggcac ccccgtgagc ctttccaccc
     1921 tggtgtgagt gtgagttgtg agtgtcagag tgtgtggtgc aggaagcctc gctggtgtga
     1981 aatcttaggt ctgccgaggc aggcacagcc cagggtgggt tctgagagac gcacatgccc
     2041 cggagagttc tgagtgggca gcggcatggc cgtttgtccc tgagagagct gcagctggga
     2101 gggaatagag tgtgagaaga gcaggctggc cgagaaagag gcaggtagcg ggaggagcag
     2161 cgagggagtg aggggctgga ctccagggcc cccctgggag gacaagctcc aggagggccc
     2221 caccacccta gtaggtgggc ctcaggatgt ccccactgat gcatccagaa aggggcacct
     2281 ccccttaacc acactgctct gtacggggca cacggacaca cgtgcacact cacagccaca
     2341 tatacgcctg agccctgcag gagcagaacg ttcacagccc agacccagct ccagaaaagc
     2401 caggggagtc ccctcccaag cccccagcgg gcattcccag gctcagcctg ctgccccagg
     2461 cccctctggc ctccctgtgt ttccactatg cacagctcag ggaccaactc cacagacccc
     2521 ctcccaggca gcccctgctc cctgcctggc catcccttcc taagcccaac taggaccgta
     2581 agcatagaca gggaggggct gcgtggggta gcatcagaag caggccagtg aaacagggcc
     2641 tgcccagggc ccctctgcct gcctctggct tctgcttggg gctcccagga gtggaagaac
     2701 tgtgccacaa ccactgtggg gacacctggc accaggactc ccacaagggg gcagtggggc
     2761 ccctgctctt gccttagaca tcttccgggc ctccccaggg ccccccgcct tctggctgcc
     2821 tctctgctct cagggccaag gtgagatgga ggttactgtc acccttgagg gtccagtcac
     2881 cagagggtga gagcaacagg tcacccaagg aagccctgcc acagagaagc cttccagccc
     2941 ataggaccca ggacc
//