From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human (clones SW11-1 and cKi-ras2-76) cellular c-Ki-ras2
Date: 31 Jul 92 10:01:35 GMT
Distribution: bionet
Checksum: 04613     4

LOCUS       HUMRASK03     789 bp ds-DNA             PRI       31-JUL-1992
DEFINITION  Human (clones SW11-1 and cKi-ras2-76) cellular c-Ki-ras2
            proto-oncogene, exon 2.
ACCESSION   L00046 K00652 K00653
KEYWORDS    K-ras oncogene; c-myc oncogene; proto-oncogene; ras oncogene;
            transforming gene.
SEGMENT     3 of 6
SOURCE      Homo sapiens (library: Lawn et al.) lung DNA; and Homo sapiens
            colon and lung cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 358 to 536)
  AUTHORS   Shimizu,K., Birnbaum,D., Ruley,M.A., Fasano,O., Suard,Y.,
            Edlund,L., Taparowsky,E., Goldfarb,M. and Wigler,M.
  TITLE     Structure of the Ki-ras gene of the human lung carcinoma cell line
            Calu-1
  JOURNAL   Nature 304, 497-500 (1983)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 789)
  AUTHORS   McGrath,J.P., Capon,D.J., Smith,D.H., Chen,E.Y., Seeburg,P.H.,
            Goeddel,D.V. and Levinson,A.D.
  TITLE     Structure and organization of the human Ki-ras proto-oncogene and a
            related processed pseudogene
  JOURNAL   Nature 304, 501-506 (1983)
  STANDARD  full staff_review
REFERENCE   3  (bases 358 to 536)
  AUTHORS   Capon,D.J., Seeburg,P.H., McGrath,J.P., Hayflick,J.S., Edman,U.,
            Levinson,A.D. and Goeddel,D.V.
  TITLE     Activation of Ki-ras2 gene in human colon and lung carcinomas by
            two different point mutations
  JOURNAL   Nature 304, 507-513 (1983)
  STANDARD  full staff_review
REFERENCE   4  (bases 358 to 536)
  AUTHORS   McCoy,M.S., Bargmann,C.I. and Weinberg,R.A.
  TITLE     Human colon carcinoma Ki-ras2 oncogene and its corresponding
            proto-oncogene
  JOURNAL   Mol. Cell. Biol. 4, 1577-1582 (1984)
  STANDARD  full staff_review
COMMENT     See comment for segment 1 of this entry.
            Complete source information:
            Human DNA (genomic library of Lawn et al.) [2]; human cDNA to colon
            (SW480) and lung (Calu-1) carcinoma cell lines mRNA, multiple
            clones [3]; human lung carcinoma cell line Calu-1 DNA [1]; human
            colon carcinoma cell line SW480, cDNA to mRNA, clone SW11-1, and
            human cell line GM637, cDNA to mRNA, clone cKi-ras2-76 [4]
FEATURES             Location/Qualifiers
     intron          order(L00045:207..>290,<1..357)
                     /number=B
                     /note="12.5 kb gap"
                     /gene="c-Ki-ras2"
     exon            358..536
                     /number=2
                     /gene="c-Ki-ras2"
BASE COUNT      210 a    124 c    161 g    294 t
ORIGIN
        1 atcaccattt tacattccca ccagcaatgc acaaagattt cagtgtctgt atccttgcta
       61 acacttattt tccatttttt gagttttttt gttttgtttt tttaataata gccaatccta
      121 atgggtatgt ggtagcatct catggttttg attttatttt cctgactatt gatgatgttg
      181 agcatctttt caggtgctta gtggccattt gtccgtcatc tttggagcag gaacaatgtc
      241 ttttcaagtc ctttgcccat ttttaaattg aattttttgt tgttgagttg tatataacac
      301 cttttttgaa gtaaaaggtg cactgtaata atccagactg tgtttctccc ttctcaggat
      361 tcctacagga agcaagtagt aattgatgga gaaacctgtc tcttggatat tctcgacaca
      421 gcaggtcaag aggagtacag tgcaatgagg gaccagtaca tgaggactgg ggagggcttt
      481 ctttgtgtat ttgccataaa taatactaaa tcatttgaag atattcacca ttataggtgg
      541 gtttaaattg aatataataa gctgacatta aggagtaatt atagttttta ttttttgagt
      601 ctttgctaat gccatgcata taatatttaa taaaaatttt taaataatgt ttatgaggta
      661 ggtaatatcc ctgttttata aatgaagttc ttgggggatt agagcagtgg agtaacttgc
      721 tccagactgc atcggtagtg gtggtgctgg gattgaaacc taggcctgtt tgactccaca
      781 gccttctgt
//