From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mast cell carboxypeptidase A (MC-CPA) gene exon 11, complete
Date: 24 Jul 92 10:07:03 GMT
Distribution: bionet
Checksum: 40003     5

LOCUS       HUMMCCPA05   1581 bp ds-DNA             PRI       24-JUL-1992
DEFINITION  Human mast cell carboxypeptidase A (MC-CPA) gene exon 11, complete
            cds.
ACCESSION   M73720
KEYWORDS    carboxypeptidase; metalloexopeptidase; secretory granules.
SEGMENT     5 of 5
SOURCE      Homo sapiens (library: lambda-gHMCCPA-4) DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Reynolds,D.S., Gurley,D.S. and Austen,K.F.
  TITLE     Cloning and characterization of the novel gene for mast cell
            carboxypeptidase A
  JOURNAL   J. Clin. Invest. 89(1), 273-282 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     mRNA            join(M73716:1805..1883,M73716:1981..2056,M73717:352..476,
                     M73718:583..685,M73718:789..890,M73718:1930..2031,
                     M73718:3663..3773,M73718:4646..4736,M73718:5754..5956,
                     M73719:467..551,486..1041)
                     /gene="MC-CPA"
     CDS             join(M73716:1816..1883,M73716:1981..2056,M73717:352..476,
                     M73718:583..685,M73718:789..890,M73718:1930..2031,
                     M73718:3663..3773,M73718:4646..4736,M73718:5754..5956,
                     M73719:467..551,486..673)
                     /product="carboxypeptidase A"
                     /gene="CPA3"
                     /codon_start=1
                     /translation="MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLA
                     KTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEK
                     QFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIG
                     EKNERRKAIFMDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVF
                     NVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSA
                     PESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIG
                     TDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPES
                     RIKPTCRETMLAVKFIAKYILKHTS"
     intron          order(M73719:552..1044,1..485)
                     /number=10
                     /gene="MC-CPA"
     exon            486..1041
                     /number=11
                     /gene="MC-CPA"
BASE COUNT      493 a    333 c    240 g    515 t
ORIGIN
        1 ataactaaat tacattttct tggtcttttg actatgaaat agtttaccct agcaacatga
       61 aaaacaagag acctaagcta ttagaagaaa tgcagttcta tgtatcttgt gtgtatagtt
      121 tttccctggg tggttttcaa cgaccagtga ctccttagct ggtttcctca gctgctagca
      181 cttgctctgg gtacttgtcc tcaacacgtc catctgcaac aatgtgtgcc taggaaataa
      241 actcaactta ctactcaccc aaccaaaatg taatttttta aacgcagcac acactgggtg
      301 gattccaaag tcatgattat gctttactat gcactctgta ctattcagac cactactctc
      361 attcattact gcaattaact gcacacataa ctatttttta ttgctaatta tacaccactg
      421 atttccactt taaaaaaaca ttagcatttg tctctaatta aatatttact gcttgtgttt
      481 tacagacccg atatcaggtt cttctttaga ctgggcttat gacctgggca tcaaacacac
      541 atttgccttt gagctccgag ataaaggcaa atttggtttt ctccttccag aatcccggat
      601 aaagccaacg tgcagagaga ccatgctagc tgtcaaattt attgccaagt atatcctcaa
      661 gcatacttcc taaagaactg ccctctgttt ggaataagcc aattaatcct tttttgtgcc
      721 tttcatcaga aagtcaatct tcagttatcc ccaaatgcag cttctatttc acctgaatcc
      781 ttctcttgct catttaagtc ccatgttact gctgtttgct tttacttact ttcagtagca
      841 ccataacgaa gtagctttaa gtgaaacctt ttaactacct ttctttgctc caagtgaagt
      901 ttggacccag cagaaagcat tattttgaaa ggtgatatac agtggggcac agaaaacaaa
      961 tgaaaaccct cagtttctca cagattttca ccatgtggct tcatcaattt atgtgctaat
     1021 acaataaaat aaaatgcact taatgcttta aaattcatct ttttatgata aacaatattc
     1081 tctgtatttc tctatagcat taataatcaa tattaatgcc attcattcag tctgttaata
     1141 agaaataata tcttcaattt tcaaaaacat aatttgccta tctttttctg atagaagtag
     1201 acattgttta tatcttcaaa aaagcaaaag gatgtcctag caggaaataa agtggttcat
     1261 atagagatga atctcagtcc tttaaataac cgatccagtt ctcatcagca taatgtacat
     1321 taaattcaaa atagtttaat ttaacctgcc ataatcagaa gaaaccacct gctaaaacat
     1381 ctgtttgccg gtacagacac agacaagaca gtctggtcag ctgtgacccc tgccctccta
     1441 atggatagaa aggaaacctg gaaacatact gtaagttgag gacggaaagt catgttgacc
     1501 aaaggcaatc agggtaactt gctgcatttg taccatttat actcctatta tttaagatag
     1561 tattattgga tagcttctcc c
//