From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human insulin receptor (IR) gene, exon 1.
Date: 15 Sep 92 10:04:40 GMT
Distribution: bionet
Checksum: 17830     6

LOCUS       HUMIRSRE     2381 bp ds-DNA             PRI       15-SEP-1992
DEFINITION  Human insulin receptor (IR) gene, exon 1.
ACCESSION   J05043
KEYWORDS    insulin; insulin receptor.
SOURCE      Human DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Tewari,D.S., Cook,D.M. and Taub,R.
  TITLE     Characterization of the promoter region and 3' end of the human
            insulin receptor gene
  JOURNAL   J. Biol. Chem. 264, 16238-16245 (1989)
  STANDARD  simple staff_review
REFERENCE   2  (sites)
  AUTHORS   Cameron,K.E., Resnik,J. and Webster,N.J.
  TITLE     Transcriptional regulation of the human insulin receptor promoter
  JOURNAL   J. Biol. Chem. 267, 17375-17383 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     prim_transcript 1281..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1288..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1355..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1356..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1393..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1394..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1429..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1431..>2381
                     /note="IR mRNA and introns (alt.)"
     prim_transcript 1505..>2381
                     /note="IR mRNA and introns (alt.)"
     CDS             1819..1917
                     /partial
                     /number=1
                     /note="insulin receptor"
                     /gene="INSR"
                     /codon_start=1
                     /translation="MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGE"
                     /partial
     intron          1919..>2381
                     /note="IR intron A"
BASE COUNT      457 a    743 c    798 g    383 t
ORIGIN      1 bp upstream of BglII site.
        1 agatctggcc attgcactcc agcctgggca acagagaaaa ctccatctaa aaaaaaaaaa
       61 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa acaaagagag agagagagag agagaggaac
      121 ggaacttggg gggaggattt gcaattaggt tagggatggc cagttcaaga tgaagccatc
      181 ctggagtgtt acgggcaagg gaaatgctgg ggcaaggcca gaggcaggat taggtttggc
      241 ctgttgctag acatgggtcc agctcctagc actgtttatt gatgagagat gatgccttgg
      301 gtctagggtt gtgctgggcg ctttcttaag ttttctttcc cgggtacctc cccaggaact
      361 cggcatgcag gtattattaa acccattaca caagtgaaac tggcccagag acagaaaagt
      421 ccctggtcca agaccacaca ggagtgaggg gtggaggaac cctcctccca ttgagttctg
      481 gctttcctat actgaaagcc ccttcctctc ctgcagtaag gtaggtggaa ccgctgtccc
      541 gccttgttgg tgaatgcgtg ctagacttca gacacataca ggctggtctg ctgaaaatca
      601 gagatgtcca cctgcgccct attcgaggtc tccgccggcg tcttctttgg cgtcgtcttt
      661 gccctttcag aagcgtctgc acatttttcc aggtgtcatt tctccaactc gaacacaggg
      721 agcgcactgg gcacgcgggc acgtggctgt ccccaggggc ctggcttggg tctcgccctg
      781 ggccggggcg cacgcgcggg cgggacatct ggggcgccca cgcgctctgg gacgagtgtc
      841 gctggccagg cccggactga ggaaaggcga gtgagacact actcgcctgg ggtgcaaaat
      901 ttaagggagt gaaaaaaaaa aaaaaagaaa gaaaccaaaa ccacctcgag tcaccaaaat
      961 aaacatttta atgcagtatt ttttaaaaaa tcaacaggaa tcctccaaag cccactatga
     1021 acaaaatagc aaaatggtag agaaaggatc tgtggccgct gcgtcgggcc tgtggggcgc
     1081 ctccgggggt ctgaaactgg aggagactcg gggctgtagg gcgcgcggat gtggggcgcg
     1141 ccctcggtcc cggcgcgccc agggcctccc gcgcggggcc cggcacaggg aggcggggag
     1201 gcgggcgggg cggggcggga ccgggcggca cctccctccc ctgcaagctt tccctccctc
     1261 tcctgggcct ctcccgggcg cagagtccct tcctaggcca gatccgcgcc gccttttccc
     1321 gcggcccgca cgggcccagc tgacgggccg cgttgtttac gggcccgagc agccctctct
     1381 cccgccgccc gcccgccacc cgccagccca ggtgcccgcc cgccagtcag ctagtccgtc
     1441 ggtccgcgcg tccctctgtc ccggagcccg cagatcgcga cccagagcgc gcggggccga
     1501 gagccgagag acagtcccgg gcgcagcgcg gagctccggg ccccgagatc ctgggacggg
     1561 gcccgggccg cagcggccgg ggggtcgggg ccaccaccgc aagggcctcc gctcagtatt
     1621 tgtagctggc gaaccggcgc gcgcccttcc cggggctgcc tctgggccct ccccggcagg
     1681 ggggctgcgg ccgcgggtcg cggtggaaga gaaggacgcg cggcccccag cgcctcttgg
     1741 gtggccgcct cggagcatga cccccagcgg gccagcgccg cgcgctctga tccgaggaga
     1801 ccccgcgctc ccgcagccat gggcaccggg ggccggcggg gggcggcggc cgcgccgctg
     1861 ctggtggcgg tggccgcgct gctactgggc gccgcgggcc acctgtaccc cggagagggt
     1921 gagtctgggg gcgcgggcgt gggcggggag ggcgcgatgg ggagaggacc cgaccaagca
     1981 aatcgagccc gctttgactg aaacctccag ggcggggcgt ggcaggacgt agctcctgca
     2041 tgcgcgtagg gagcggaagc ctctgacctt ggcctttggc ccgcccgggc tcgcctccgc
     2101 gccctgcgtg cccgacctga gcccgaggaa ccttgcccca gtgcccgccc gccgcgggct
     2161 cctctctgga gcgcgcctcc gacccgtgcc ccggcccctc cgagcccaag tcgctccgga
     2221 gacacgacac gcgtcatgct ttgggtcgcg gccgggaagt gggggtcact ggtgctggac
     2281 agccccgaac agccaagtcc cccgagcgca tatgtgtagt agagccaagc gccctgagtg
     2341 cctcaccggt gggtgacgct gcctggggtc agggactgca g
//