HDTenEightyP/NetNews huggingface dataset:
From: rowe@engin.umich.edu (Steven Rowe)
Subject: Request for references on biological cell assemblies
Date: Tue, 13 Oct 92 20:32:06 EDT
Organization: University of Michigan Engineering, Ann Arbor
Followup-To: (none) 
Distribution: bionet.neuroscience

Hi, all.  I am an engineer attempting to build a computational model
of groups of highly interconnected cortical neurons.  I have practically
no biological background.  I was wondering if you bionet folks could
e-mail me references for the following topics:
 
1)  Any evidence of fatigue in cortical neurons, especially data on
    firing potential with respect to time and number of firings per
    unit time.
 
2)  Any studies done on the activity patterns of cortical cell as-
    semblies.
 
Please e-mail postings to steve_rowe@35.1.1.47
 
Thanks in advance.
                        Steve Rowe
 
-- 
     These folks who don't believe in evolution
are the ones who look the most like they could use some.

                                   -Frank Allison
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.neuroscience
Subject: Re: WELCOME to rec.neurosci.funny!
Date: 16 Oct 92 18:25:09 GMT
Organization: BIOSCI International Newsgroups for Biology

inunn@hpb.hwc.ca writes:

>Perhaps this group could become moderated to filter out the pop culture noise.

If someone wants to step forward and volunteer to do this (they need
to be conversant with USENET news software), please contact me and we
can get the wheels in motion to do this if the readeship of the group
agrees.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: ringo@craft.camp.clarkson.edu (Ringo)
Newsgroups: bionet.neuroscience
Subject: Re: hottest topic
Date: 7 Oct 92 14:33:24 GMT
Distribution: bionet
Organization: Clarkson University

pck@castle.ed.ac.uk (P C Knox) writes:

>tsau@FRED.MED.YALE.EDU writes:

>>  What is the hottest topic on neuroscience?

>Well, I don't know about "on" Neuroscience, but IMHO in Neuroscience it
>whether extra-ocular muscle afferent signals really are involved in
>oculomotor control!

Nope. Heart Rate Spectral Analysis :) (IMHO, of course)

--John Rescigno
Dept. of Psychology
Clarkson University
Nowhere, NY
From: BI599101@BROWNVM.BROWN.EDU (Robert Swift)
Newsgroups: bionet.neuroscience
Subject: Re: Neurotransmitter questions
Date: 7 Oct 92 11:40:46 GMT
Distribution: bionet

Your question on neurotransmitters is excellent but I'm not sure that we really
know all the answers. Neurotransmitters do many things to alter signal transduc
tion in neurons, by affecting ion channels, intracellular processes such as pho
sphorylation and probably affect the ability of the neurons to connect and form
 functional synapses. Affects are both short-term and long-term.

      A good reference (cheaper then Kandel and easier to read) is The Biochemi
cal Basis of Neuropharmacology by Cooper, Bloom and Roth. There is a new editio
n out recently. It is probably available at your library as well.

  R. Swift
  Brown University, Box G RW
From: agnew@gems.vcu.edu
Newsgroups: bionet.neuroscience
Subject: Re: Affecting Hallucinations - Assassins
Date: 12 Oct 92 08:17:15 -0400
Organization: Medical College of Virginia

Dear Netpeople,
  On this thread about the Assassins..  There is an excellent treatment in the
mode of "historical adventure" in Louis L'Amour's book "The Walking Drum"
Late in the book the hero gets his dad away from the assassins.  Since
L'Amour does enough research to be accurate, that is a good source, as
well as good reading.  long, tho..  We now go back to neurotransmitters,
not six-guns!!

Pardon me, but I had to mention it since it was such a good book..

-- 
         /^^^\   \ /   Jim Agnew         AGNEW@RUBY.VCU.EDU  (Internet)
        /      >  ||   Neurosurgery,     AGNEW@VCUVAX        (Bitnet)
   /\_/     '   \  /   MCV-VCU           This tape will self destruct in
 /________________>    Richmond, Va      five seconds.  Good luck, Jim..."
From: BI599101@BROWNVM.BROWN.EDU (Robert Swift)
Newsgroups: bionet.neuroscience
Subject: Re: Any info on Zoloft?
Date: 16 Oct 92 08:22:21 GMT
Distribution: bionet

Zoloft, generic name sertraline, is a new serotonin reuptake blocker antidepres
sant. It is similar in action and side effects to fluoxetine, trade name Prozac
. These 5HT uptake blocking antidepressants generally have fewer side effects t
han do the usual tricyclic antidepressants. As for interactions with diabetes,
tricyclics may sometimes inhibit insulin release. I'm not sure about whether th
e 5HT uptake blockers have this activity as well. I should also say that I am a
 psychiatrist and find that Zoloft is effective and well tolerated in the sever
al patients of mine who are taking it. IIn the front of the PDR is the phone nu
mber of Pfizer which makes Zoloft. They will send you tons of information if yo
u call them and request it. I hope this is helpful to you.

                                                 Bob Swift
                                                 Brown University
From: pechan@mike.dnet.gwdg.de ("MIKE::PECHAN")
Newsgroups: bionet.neuroscience
Subject: bFGF-recombinant or native?
Date: 14 Oct 92 09:20:17 GMT
Distribution: bionet
Original-To: neur-sci@uk.ac.daresbury

Hi everyone:
We have a question - have human recombinant basic FGF(bFGF) similar neurotrophic
effect on rat neurons as native bovine bFGF?
                                    Peter Pechan
                                Department of Neurobiology
                                Max-Planck-Inst., Goettingen, Germany
                                E-mail:pechan@MIKE.dnet.gwdg.de
From: CFINNEY@UVMVM.BITNET (Chris Finney)
Newsgroups: bionet.neuroscience
Subject: Neurotoxin Question
Date: 7 Oct 92 20:19:32 GMT
Distribution: bionet

Hi!

You're probably thinking of the tryptamine called bufotenin which is
found in some species of toads of the Bufo genus.  I don't know if any
frogs produce this compound. That's all I know.

                             -Chris
From: xpei@gwdgv1.dnet.gwdg.de ("GWDGV1::XPEI")
Newsgroups: bionet.neuroscience
Subject: Cell numbers.
Date: 16 Oct 92 17:50:00 GMT
Distribution: bionet
Original-To: Neur-sci@uk.ac.daresbury

Dear Colleagues.

	Could you tell me that how many ganglion cells project to the
lateral geniculate nuclei and how many relay cells in the LGN project
to the primary visual cortex? I could not find the data. Thank you very
much in advance.
                                               Sincerely yours Xstern Peiter.
E-mail:Xpei@gwdgv1.dnet.gwdg.de
From: stenberg@klaava.Helsinki.FI (Dag Stenberg)
Newsgroups: bionet.neuroscience
Subject: Re: breakfast and brain health
Date: 13 Oct 92 21:43:54 GMT
Organization: University of Helsinki

rs69@cunixb.cc.columbia.edu (Rong Shen) writes:
: school who did not do well academically and all the graduates who had
: not received licenses for medical practice did not have the habit of
: eating breakfast. Since neurons are unable to metabolize proteins or
: other cell constituents, once the glucose concentration in the blood
: falls, the brain can not function to its full capacity.
: 
Yes, but the liver can release glucose into the blood stream from its
stores, and does that quite effectively.

: its former glory. But the guy who posted the article about losing
: neurons in the lab instilled a vast fear in me: I am afraid that,
: having starved myself for four semesters, I have lost so many neurons
: that the dullness of my mind has become permanent, irrevokable by any
: healthy habits.
: 
While regular eating habits are of advantage for full brain performance,
the risk of losing neurons because of not having breakfast seems slight.

Dag Stenberg, MD, PhD
Dept.Physiology, Univ.Helsinki,Finland
From: GREENSPA@SNYSYRV1.bitnet
Newsgroups: bionet.neuroscience
Subject: Hottest topic
Date: 7 Oct 92 21:44:00 GMT
Distribution: bionet


  It seems to me that the current fad in neuroscience is nitric oxide
(just say NO), which does so much that I wonder if we need neurotransmitters.

Joel Greenspan
Dept. of Neurosurgery
SUNY Health Science Center
Somewhere, NY
From: rchafetz@cephalo.neusc.bcm.tmc.edu (Ross Chafetz)
Newsgroups: bionet.neuroscience
Subject: Differential express of proteines in the Hippocampus
Date: 16 Oct 1992 18:00:21 GMT
Organization: Baylor College of Medicine, Houston,Tx
Distribution: world
NNTP-Posting-Host: cephalo.neusc.bcm.tmc.edu





Does anyone know of proteins that are expressed in CA1 pyramidal cells but not in
CA3 or CA2 pyramial of the hippocampus (I'm separating CA1 and CA2 at the end of the
mossy fiber projections).  The protein can be express in other regions
of the brain, but I'm particularly interested in differences in the pyramidal cell
layer.  I believe this is somewhat true with some Ca binding proteins
(could anyone confirm this).


:)
Ross
Newsgroups: bionet.neuroscience,alt.drugs
From: ebrandt@jarthur.claremont.edu (Eli Brandt)
Subject: Re: Neurotransmitter questions
Organization: Harvey Mudd College, Claremont, CA 91711
Date: Sat, 10 Oct 1992 06:49:06 GMT

In article <ringo.718380479@craft.camp.clarkson.edu> ringo@craft.camp.clarkson.edu (Ringo) writes:
>LSD is a similar chemical to Serotonin, and mimics its effects.

Well, yes and no, literally.  I don't remember the hairy details,
but LSD acts as an agonist at some classes of 5HT receptors, and
an antagonist at others.  Niggling continues over the fine points.

Clearly neither 5HT agonism or antagonism is sufficient; consider
serotonin itself, and BOL.  Psychedelics' method of action remains
up in the air.

My theory of psychotropic drug research is that maturity in research
on a given class of substances occurs after both the "we don't know
what's going on" phase and the "they work by inhibiting catecholamine
reuptake. [or `by antagonizing 5HT', or whatever]" phase.  This phase
of maturity is characterized, of course, by a return to the "we don't
know what's going on" phase.  Only half in jest...

>--John Rescigno

   Eli   ebrandt@jarthur.claremont.edu


Xref: sparky bionet.neuroscience:448 sci.med:18916 sci.bio:3526 alt.drugs:16884
From: de0t+@andrew.cmu.edu (Daniel S. Efran)
Newsgroups: bionet.neuroscience,sci.med,sci.bio,alt.drugs
Subject: Re: Affecting hallucinations via other drugs
Date: 9 Oct 92 13:45:33 GMT
Organization: Junior, Math/Computer Science, Carnegie Mellon, Pittsburgh, PA

Excerpts from netnews.alt.drugs: 9-Oct-92 Affecting hallucinations vi..
Allen Smith@yang.earlham (1371)

>         I started wondering what the effects of combining hallucinogens
> and pleasurable drugs would be. In other words, could one influence the
> course of the "trip" by taking other drugs along with it?

A 'friend' tells me that cannabis will intensify/modify the
effects of LSD quite pleasantly.  Not sure of the mechanisms
involved, but the result is more intense than the sum of the
two effects separately, though it is of that character.

Presumably other combinations have different effects, but
remember that alcohol can be dangerous to combine with
some other drugs.  It's probably physically ok with LSD or
similar chemicals (references, anyone?) but remember that
it's a depressant and can be very dangerous when combined
with, for example, other depressants.  I don't know the 
specific contraindications, but it's probably a good idea to
find out before experimenting.

	---Daniel Efran
----------------------------------
An it harm none, do as you Will.
Practice random kindness and senseless acts of beauty.
From: pei@mike.dnet.gwdg.de ("MIKE::PEI")
Newsgroups: bionet.neuroscience
Subject: Resistance
Date: 16 Oct 92 19:08:49 GMT
Distribution: bionet
Original-To: neur-sci@uk.ac.daresbury

Dear colleagues,
	I have a question about the input resistance measured during whole cell
recordings. How large should it be if one get a Gig-seal? Could you please give
me some information about it. Certainly it will depend on the size of a cell.
But what about the range, for example the pyramidal cell in the visual cortex.
					Thank you. Xing Pei
Newsgroups: bionet.neuroscience,alt.drugs
From: kevin@neuron.arc.nasa.gov (Kevin Montgomery)
Subject:   WELCOME to rec.neurosci.funny!
Keywords: semen fer brains
Organization: NASA-Ames Biocomputation Center
Date: Thu, 15 Oct 1992 18:39:50 GMT

this net is just to weird for me...

			:-)
From: xpei@gwdgv1.dnet.gwdg.de ("GWDGV1::XPEI")
Newsgroups: bionet.neuroscience
Subject: Mono-synaptic connection
Date: 16 Oct 92 17:42:14 GMT
Distribution: bionet
Original-To: Neur-sci@uk.ac.daresbury

Dear Colleagues.

	I am studying the neuro-anatomy now, and look for
the mono-synaptic (direct) cennection between each part of the brain.
I know only a bit about it, e.g. the retina is direct connect to LGN
(the lateral genicular nuclei in Thalamus). Would you please give
me some more information about which part of the brain project to which
other part. Please specify the specimen. Thank you very much in advance.
                                               Sincerely yours Xstern Peiter.
E-mail:Xpei@gwdgv1.dnet.gwdg.de
Xref: sparky bionet.neuroscience:438 alt.drugs:16788
From: thom@crayfish.ucsd.edu (Thom Cleland)
Newsgroups: bionet.neuroscience,alt.drugs
Subject: Re: Neurotransmitter questions
Date: 8 Oct 1992 00:08:33 GMT
Organization: Tenuous at best
NNTP-Posting-Host: crayfish.ucsd.edu


Hi all.  Regarding the thread on neurotransmitters, and how greater
complexity derives from "inhibition" and "excitation", and how more
than two neurotransmitters are thereby useful...

I won't repeat what others have stated, but just make two points.

First, the ideas of 'excitation' and 'inhibition' refer to the 
membrane polarization level of a cell, as you noted; what these
labels obscure is the fact that the voltage across a cell membrane
can change via several different currents.  The action potential is
"sodium rushes in (depolarization), then potassium rushes out (re-
polarization)", dogmatically, but in the complex behavior of neurons
studied at the cellular level many different channel types exist.  There
are fast sodium currents  (inward), fast and slow calcium currents
(inward), fast, voltage-dependent potassium currents, slow voltage
dependent potassium currents, slow, calcim-dependent potassium currents,
"inwardly-rectifying" potassium currents  (all outward), hyperpolarizatin-
activated inward currents,  and many more.  They turn on at different
times, off at different times, at different levels and with different
kinetics and may be dependent on or independent of voltage.  Different
currents have different impacts on any number of significant factors--
firing rate, burst frequency, resting potential.  They may interact in
complex ways... for instance, calcium entry first activates, then
at higher concentration inactivates a particular potassium current in
some Aplysia neurons....  We are right in the midst of this sort of
sorting-out research at present.  

Neurotransmitters and neuromodulators affect specific currents in specific
ways, as others have noted... thus nearly anything, conceiveably, can
be changed.  To reduce the effects to "excited" or "inhibited" is like
just stating who won an election--it's certainly pertinent, important
information, but clouds over all the reasons, campaigns, social movements,
national mood, issues, previous records, and all that influenced the
election outcome and whose influences do not cease simply becuase the
election outcome is a boolean result.  

I think my second point is in there somewhere.  If not, I've forgotten it.
Long day.

hope this is of use!  

Thom Cleland
tcleland@ucsd.edu
Dept. of Biology, UCSD
Cellular mechanisms of neural central pattern generation in crustacean models.

-- 
Thom Cleland     \ /^^/  >Neural systems/network physiology< >Amigaphile<  
(619) 453-7516    \OO/  >Aoinagi Shito-ryu == bend, and the wind passes <
tcleland@ucsd.edu  ++  >B3 f cdv g++ k+(+) m s+ r+ p growl+ purr++ zzz- <
"Wild magic is graven in every rock, every tree, in every blade of grass"
From: vance_baird@QUICKMAIL.CLEMSON.EDU ("Vance Baird")
Newsgroups: bionet.genome.arabidopsis
Subject: karyotype
Date: 13 Oct 92 09:35:15 GMT
Distribution: bionet


                       Subject:                               Time:5:39 PM
  OFFICE MEMO          karyotype                              Date:10/13/92
Can anyone direct me to a catalog, "dictionary", etc. of plant karyotypes?  At
least a listing of plants for which this type of analysis has been
accomplished?  Thank you.
Vance_Baird@Quickmail.Clemson.EDU

FAX 803-656-4960
From: kristoff@NET.BIO.NET (Dave Kristofferson)
Newsgroups: bionet.genome.arabidopsis
Subject: Mike Cherry will handle the address directory
Date: 16 Oct 92 18:42:13 GMT
Distribution: bionet


After exchanging mail with Mike Cherry and Chris Somerville, we have
agreed that Mike will assume the responsibility for updating the
Arabidopsis address directory from here on as part of his AAtDB
project.  Please ignore my posting of yesterday evening about a new
survey.

                                Sincerely,

                                Dave Kristofferson
                                BIOSCI/bionet Manager

                                kristoff@net.bio.net
Newsgroups: bionet.genome.arabidopsis
From: barbet@tournesol.versailles.inra.fr (Jean-Claude Barbet)
Subject: POSTDOCTORAL POSITION
Original-To: arab-gen@uk.ac.daresbury, postdoc_position@fr.inra.versailles.tournesol
Pp-Warning: Illegal Received field on preceding line
Original-Received: by tournesol.versailles.inra.fr, Mon, 12
                   Oct 92 17: 53:32 +0100
Distribution: bionet
Date: Mon, 12 Oct 1992 16:53:32 GMT
From: PLXZW@VAX.CCC.NOTTINGHAM.AC.UK
Newsgroups: bionet.genome.arabidopsis
Subject: Postdoc Job Ad
Date: 12 Oct 92 16:31:00 GMT
Distribution: bionet
Original-To: ARAB-GEN@UK.AC.DARESBURY

University of Nottingham
Department of Life Science

POSTDOCTORAL RESEARCH ASSISTANT
IN PLANT MOLECULAR BIOLOGY

Applications are invited for a 3 year postdoctoral research post, 
funded by the AFRC Plant Molecular Biology Programme.  The 
postdoctoral scientist will join an active team investigating male 
sterility in Arabidopsis thaliana.  The overall aims of the project 
are the mapping and cloning of genes involved in male 
gametophyte development.  

Candidates should have experience in molcular biology and 
knowledge of plant genetics, plant transformation using 
Agrobacterium tumefaciens  and/or DNA sequencing.  The salary 
will be on the RA 1A scale. 

Applications, including a cv. and the names of two referees 
should be sent by to Dr. Zoe. Wilson, Department of Life 
Science, University of Nottingham, NG7 2RD.  
Further details can 
be obtained from either Dr. Zoe Wilson (0602 513235) or Dr. 
Bernard Mulligan (0602 513236).
From: mah@CSHL.ORG (Hong Ma at CSHL (Delbruck))
Newsgroups: bionet.genome.arabidopsis
Subject: Arabidopsis mutants
Date: 7 Oct 92 15:31:34 GMT
Distribution: bionet

Dear Arabidopsis biologists:
Elliot Meyerowitz and I are putting together a list of Arabidopsis mutants
and variants.  If you have unpublished information or paper in press about
new mutants, new alleles of previously defined genes, new information about
existing mutants, including but not limited to map positions, phenotypes, 
growth requirements, and molecular data such as clones, nature of mutations,
please send them to me by mail or by E-mail, if you don't mind the info to
be included in our list.  We are trying to find all available information
and to assemble an as complete a list as possible.  Other genetic variants
such as different ecotypes, inbred lines and so on are also welcome.

Please be sure to include the method of mutagenesis if the mutants are new.
Also list all available references.  If you find a reference on existing 
mutants in recent journal which may not have been entered in the reference
databases yet, I will also greatly appreciate your letting me know about it.

Thank you very much in advance for your cooporation.

Sincerely yours,
Hong Ma
Cold Spring Harbor Lab.
1 Bungtown Rd.
Cold Spring Harbor, NY 11724
(Tel) 516-367-8309
(fax) 516-367-8369
E-mail mah@cshl.org
From: CHERRY@FRODO.MGH.HARVARD.EDU (Mike Cherry 726-5955)
Newsgroups: bionet.genome.arabidopsis
Subject: Arabidopsis Colleague Directory
Date: 16 Oct 92 19:53:05 GMT
Distribution: bionet

We are in the final stages of building the next release of AAtDB. If
wish to be included in the AAtDB 1-2 Colleague information you are
invited to use the following form. Please send the completed form via
electronic mail to curator@frodo.mgh.harvard.edu or FAX your
information to (617) 726-6893. You can also use the form below at
anytime to submit new or change your information in the database.

The Colleague information is currently just a small part of the
material available via the Unix AAtDB database of Arabidopsis
information, the Arabidopsis Research Companion WAIS and Gopher
Internet servers, and the public access Gopher account on
ochre.mgh.harvard.edu (username: "gopher", password: "thaliana").

If you need more information about any of these services please
contact Sam Cartinhour or myself at the curator@frodo.mgh.harvard.edu
mail address. Suggestions for how to improve these services are also
welcome.

Mike Cherry


Full Name:
Position:
Profession:
Full Postal Mail Address:
Country:
Telephone:
Bitnet Electronic Mail Address:
Internet Electronic Mail Address:
Other Electronic Mail Address:
Fax Number:
Telex:
Brief description of Research interest:
Keywords describing your research:
Members of Lab Group or Associates:
From: BTNYDWM@MVS.UCC.OKSTATE.EDU
Newsgroups: bionet.genome.arabidopsis
Subject: Survey Update
Date: 13 Oct 92 13:43:00 GMT
Distribution: bionet

To the Arabidopsis Community:

The following laboratories have responded to the mapping
and nomenclature survey recently distributed through this
email network by Mike Cherry (AAtDB) and by postal mail
from ABRC at Ohio State University:

Form # 1 (Mapping Data - Mutant Genes)

Deng (Yale)
Estelle (Indiana)
Jurgens (Munich)
Meinke (Oklahoma State)
Relichova (Czechoslovakia)
Meyerowitz (Cal Tech)
Crawford (UC San Diego)
Finkelstein (UC Santa Barbara)
Crute (AFRC)
Cobbett (Australia)

Form # 3 (New Gene Symbols)

Callis (UC Davis)
Dangl (Germany)
Deng (Yale)
Estelle (Indiana)
Green (British Columbia)
Jurgens (Munich)
Last (Boyce Thompson)
Meinke (Oklahoma State)
Ohlrogge (Michigan State)
Pyke (York, UK)
Relichova (Czechoslovakia)
Somerville (Michigan State)
Sung (UC Berkeley)
Thomashow (Michigan State)
Williamson (Australia)
Meyerowitz (Cal Tech)
Comai (Washington)
Gasser (UC Davis)
Crawford (UC San Diego)
Cobbett (Australia)

This is a good start, but is still not representative
of the entire community.  If your name is not on this
list, and you have gene symbols or mapping data to
contribute, please return your completed forms this
week.  If you know of a lab that has information to
contribute but is not on the above list, please call
them or send an email message and encourage them to
respond.  Genetic maps and databases are of limited
use if they are incomplete.

David Meinke