From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mus musculus (clone lambda-17a, lambda-20b) aldose reductase (MVDP)
Date: 1 Sep 92 10:03:12 GMT
Distribution: bionet
Checksum: 03146    18

LOCUS       MUSMVDPA    11026 bp ds-DNA             ROD       01-SEP-1992
DEFINITION  Mus musculus (clone lambda-17a, lambda-20b) aldose reductase (MVDP)
            gene, complete cds.
ACCESSION   M81448
KEYWORDS    aldose reductase; androgen-dependent secretory protein;
            secreted protein.
SOURCE      Mus musculus (strain BALB/c, sub_species domesticus) (library:
            Clontech cat. ML1009) adult liver, vas deferens DNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (sites)
  AUTHORS   Pailhoux,E.A., Martinez,A., Veyssiere,G.M. and Jean,C.G.
  TITLE     Androgen-dependent protein from mouse vas deferens: cDNA cloning
            and protein homology with the aldo-keto reductase superfamily
  JOURNAL   J. Biol. Chem. 265, 19932-19936 (1990)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 11026)
  AUTHORS   Pailhoux,E., Veyssiere,G. and Jean,C.
  TITLE     The genomic organization and DNA sequence of the mouse vas deferens
            androgen regulated protein gene
  JOURNAL   Unpublished (1991)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             join(557..622,3456..3623,4246..4362,5407..5484,7116..7238,
                     7531..7637,8041..8122,8570..8653,9182..9264,10962..11004)
                     /EC_number="1.1.1.21"
                     /product="aldose reductase"
                     /gene="MVDP"
                     /codon_start=1
                     /translation="MATFVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHID
                     CAYVYHNENEVGEAIQEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKL
                     DYLDLYLVHWPQGFQAGNALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGIS
                     NFNHFQIERLLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDR
                     PYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQV
                     FDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYPFHEEY"
     CAAT_signal     446..449
                     /gene="MVDP"
     exon            511..622
                     /number=1
                     /gene="MVDP"
     intron          623..3455
                     /number=1
                     /gene="MVDP"
     exon            3456..3623
                     /number=2
                     /gene="MVDP"
     intron          3624..4245
                     /number=2
                     /gene="MVDP"
     exon            4246..4362
                     /number=3
                     /gene="MVDP"
     intron          4363..5406
                     /number=3
                     /gene="MVDP"
     exon            5407..5484
                     /number=4
                     /gene="MVDP"
     intron          5485..7115
                     /number=4
                     /gene="MVDP"
     exon            7116..7238
                     /number=5
                     /gene="MVDP"
     intron          7239..7530
                     /number=5
                     /gene="MVDP"
     exon            7531..7637
                     /number=6
                     /gene="MVDP"
     intron          7638..8040
                     /number=6
                     /gene="MVDP"
     exon            8041..8122
                     /number=7
                     /gene="MVDP"
     intron          8123..8569
                     /number=7
                     /gene="MVDP"
     exon            8570..8653
                     /number=8
                     /gene="MVDP"
     intron          8654..9181
                     /number=8
                     /gene="MVDP"
     exon            9182..9264
                     /number=9
                     /gene="MVDP"
     intron          9265..10961
                     /number=9
                     /gene="MVDP"
     exon            10962..11026
                     /number=10
                     /gene="MVDP"
BASE COUNT     2910 a   2430 c   2448 g   3238 t
ORIGIN
        1 tctagaaagg tgtccatgac ctacatttaa aaaaaaaaaa aatctttcca caaggtcacc
       61 tgccagtttc ctctgtaaca gacatccctt agttttgtgg ccaaggacag ttatttcaaa
      121 gtagttactg taaaagatgt ctcatttttc ctcgacattt ttatttgcct caaactgcat
      181 gagcacccac gcagttcact agcgttatat cactcccagg gcaatgaccc ttcccaaata
      241 aacttaccag ttcatcttgg atgacctttc aaccatgtca cttaggttca caaacctctg
      301 atccgatacc caataaagca tcgattctgc ccagatagcc tttgcactgt gctgacttta
      361 atctttgttt acgatgatca gtgtggcaca agattgacat gaagttcctg ttctcatgcc
      421 ccaacccttg gctgtggctg cttgccaatg tggtaagagc ccgcctcctt tatccaggac
      481 ataaaaatgt caccagcctc cttgtagaga aagcaggcat ttcatctgct cactcagaga
      541 actctctgca gcaaccatgg ccaccttcgt ggaactcagt accaaagcca agatgcccct
      601 tgtgggcctg ggcacctgga aggtgagtgt gcagtcttgg gacacctgct gcctttgagg
      661 ggaggtctgg acattttctt ttctgtgcag agcatctatc tgccttgggt ttgataaggc
      721 cagcattatc acctgttgtc agctgctttg ggttgcagat gagcctttcc cagaaatgac
      781 aatagcttcc ttggcgaata tcaggtttaa atttgtacaa tttttcaggg agaaaactgt
      841 tttcagggaa gttttctctt agaaagcctt tccttgggac tctgagggtc tctgttggtt
      901 tgttactggt ctgagtgact gagagagagt atagagttct taatgacccc actcttatga
      961 tgcaagacta tgccaacatc tgagtggcct gggagcttgt gggaaaggca gaggacaact
     1021 ggactggccc aggcagttta caaatctcca tgtgattccc ccacacctta agacccatgc
     1081 agcatgagag ccacagaatt ggagtcagct caaagtctgc cctggctgtg ttaatctcta
     1141 ctggcaagtt gctctgtggc cctaccagta cccagtgaaa cagatttctc gaaatcttgg
     1201 gacaagtctg acattggtcc atcttcttct aactctgcct tctttgctgt ttctattact
     1261 gacaacatga gagtagccag cttgttaacc aggagctgtt tttagttttg attttgattt
     1321 cttgagacag ggtttctctc tctctaacct aaaatgacct tgatcaaatt tggagtaatc
     1381 ctcctgcctc agcttcttga atactgggat tataggtgtg agccttcatc cttggctcag
     1441 gagtagtttg ggaacccatc tgtcttagtt agggttttac tgctgtgaat agacaccacg
     1501 accaaggcaa gtcttataaa aaacaacatt taattggggc tggcttacag gttcagaggt
     1561 ttagtccatt atcatcaagg tgggagcatg gcagtatcca ggcaggcatg gcacaggcag
     1621 acgtgagagt tctatgtttt catccaaagg cctgctagtg gaagactgac ttcctggcaa
     1681 ctggggtgag agtcttaagt ccacacccac gtgacacacc tactccaacc aggcaacacc
     1741 tccagacggt gccactccct gctccaagaa tatacaaacc atcacaccat ctgtcctgtg
     1801 tccaagactc atttccagtc ttcctctgtt tctcttttct ttacacagag ggtaggttct
     1861 ctctttgttt ctacattaga ttggggtctt actagaatgg tgagacttgc aaccagagta
     1921 gaaatttcac attccctcaa ggtgacaaat aattacaaat ctccaggata ctcaccctgg
     1981 acaaatttag aagaaatgca ctttcagagt tccaaaagca tttgtaaata tttgtaagaa
     2041 gttgttttcg aggtaaggac tctgtgctca ccagtggaca agcaggaggg tgacactttg
     2101 ccctgggccc cagtgctttt gtgtttctgg aaattccttc tcctcatgat ggcagagctg
     2161 ttgatctctg ctctctgtgc ttctcaaggt ttgatgctta aaaacagaac ctttagattt
     2221 agtaataggg gaagagttat ttatgggctg ttgtttgaga gtcttccaca gccctggtta
     2281 ccttataata attcattatg tggctgagac tggccctgaa ctcctggttt tcctactcac
     2341 ctcccaaatg ctaggattaa aacatgggcc accacatcca gtgagatgtt gttttgtatt
     2401 gactgagata atattgtgcc ccaggctgtc ctcaaagcca cagcctggcc ctcctacctt
     2461 tgtgcctctc atggtggtgt tacagccatg cagcaccatg ctctgcagag aggtacgtga
     2521 tgagtacttc tctcctaagc caatacctgg cttggttagg tcaggacaga aggtgaccca
     2581 cttcaaatgc tccttccctt ggctccttgg cttgttttct ctttctttct ctctctttct
     2641 ctctctctct ctctctgtct gtctctgtct ctgtctctgt ctctgtcttt gtctctgtct
     2701 ctgtctctgt ctctctctct ctctctctct gtagtccata tgggaaatcc atttttataa
     2761 agtttctgtt aggtttaaaa ctgaggacaa agaaatgaag tgcctattta acatcttcct
     2821 gtttgctctt tttctgaaac agtgattaca tattggattg caagtgccag gtgatgtgct
     2881 gaaatcttca caatcttgtg gcaagctggc aacacaaagg cctcatggca gggcccataa
     2941 cttgctatgt tttctgtcaa ggtttaggga aattgaggaa tctgctcagc ctcatactgc
     3001 accatagcag agttcaaatc acattgctat aatatatttt ttaaagatcc ttctaactgt
     3061 ctggagtctg agaactcctc ctcagaatct agttttcagg ctagccttgc aagtttcaag
     3121 gggagtcatt tgtcactcag aaactggagg cacttcaaga tcaacctgga ctggaggact
     3181 agaataggac acgagtcaga atcatgacaa tgacatgtgt attaagatgc cataatgaaa
     3241 tccatcactt gtatgataac ctaaaaattt agtgaaataa aaaaagtaat tcactttttc
     3301 ttttcctggg agaaacccct cagtgtatgt tttcttctcc caagtccact tgggaacagg
     3361 actgcagcaa ggctgtggtt ttcagaatct ggtctatgtg gagcccttaa gaagaggcct
     3421 tggagcatct aatggtcttt tctattgcct ttcagtcttc cccaggccaa gtcaaggaag
     3481 ccgtgaaggc ggccattgat gctgggtatc gccacattga ctgtgcctat gtgtatcaca
     3541 atgagaatga ggtgggagaa gctatccaag agaagatcaa agagaatgct gtgaagcggg
     3601 aggatctctt catcgtcagc aaggtacaat gatgcacttg gtggacaaga cttccaggca
     3661 ggtggaagta tctgtgtagg ggcaggtttg agagttattc gcctttcttt gtgggcctgc
     3721 atgtctcctg gccctttgtt ccctgctttc attatgtctc ttggtagaat tccacacaca
     3781 aaaacatcca ctgttggagt ggccacacct atatatgtgt atataggtat atgtgtatat
     3841 gctcattgcc attcatcaca gggcctgaca ggctggggat aagggagtac taaaaagggc
     3901 cagccctcct attgcatcgt aatacttgaa cttgaagagc cacaaacaac tcctgccatc
     3961 tgagaaatga gagccacaga aaagcatgtg acacaagaat aattctagtc acgcgactaa
     4021 gttaaatgac taagaaacaa accaatatcg agagcatagg ggaacactag aagtgatgtt
     4081 gacttgctaa gagctgatga taagaaatac gttgcatttc ttaacgtatt tcttataagt
     4141 gaatagccgg tcctggggtg tacaaatctc caagcaggag gagtaactgt agtatgtgtg
     4201 gccttcctct ccctagttct aatgctcccc tgttacaccc tgcagctgtg ggccacattc
     4261 tttgagaaaa gcctggtgaa gaaagccttc cagaacaccc tctcggatct gaagctggac
     4321 tatctggacc tgtatctggt ccactggcca cagggatttc aggtttgagc tgctctttgc
     4381 cttctatttt tggggagatg ctacaaagtg gctatggtgc caagactgtg acactgggga
     4441 gggatgaagc agggggttgg gtttgagttt tatctatttt ttgtatatga gcgttttgtt
     4501 tactgtatat gtgtgcacca tgcctatgct tggtgcctgt ggagatcaga agagagcatg
     4561 ggatccctgg gaattggagt tatggatggt tgtgaaacac cacctgggtg ctaggaaccc
     4621 aacctgggtc ctctgcaaga gcagcaagtg ctctcatctt ctgacccacc tctctagtcc
     4681 ccagaagact gtgcagcgcg gaggctgagg caacaggtgg tacttggtga gactcatgct
     4741 tggttttctg caattgtgtt tgaaagaaac agtatttctt ctaccagctc agataactgc
     4801 aactggccag ccatcttcct cttggatgca tgcccatgag tgcccttggt aggatgtctt
     4861 ggggcactct tgcataagtt cctattaatc aaagtgtgcc cagagagtga cctccatgtg
     4921 tggtgatatt gacagttagc cagtccaacc tgaagaaata ttgcatagtg tctggaggga
     4981 tgtggattct ttttgctgta ggcccttatg aacagccttg gtgagagtgg catggtctcc
     5041 aaactcaggc cttctccagg ttgcaagtta ggagaagctg gttactctct tcctcagata
     5101 accatactct tctgatataa aacctctgcc tagtgacctt gaagtttaca ttggttaact
     5161 tccacgatga tagtgatggc ttctataata tactagagga cttggagcca gctgagtatt
     5221 gccagaaata gaggactgac ttcccatggt agactgacac aggaattttt tttgaatatt
     5281 atatttttat gtgagttctc tggaatttga catgggtact tcttatttcg ccgtcctgag
     5341 acgtctcttc acaggaccag gtaactaaat gccgattctg gtgatatttt tgtttctcat
     5401 ttacaggctg ggaatgcgtt attacccaaa gacaataaag gcaaagttct cctgagtaaa
     5461 tccacattct tggatgcctg ggaggtaggt tccaacttcc ttcaagtgtg ctgctcaaag
     5521 ttaaaataca aatcttctct cagatgctgt tgagactcca ccctggtatg gaaaggctca
     5581 agtgctctgt atataatttc agaatgctta ttctctagtt ccccctctgt cctggaaagt
     5641 ggtgtctgtg gagctacttg tgaaagtcag agggcagcta cccaaagtag gttctttcct
     5701 tctatcacat aggctccagg aagaaactgt gaccatctag cttggcagca aggaccttta
     5761 cccactgaaa catttccctg gccccatgaa acactttcag gaacaacaac aacaacaaaa
     5821 aaaccaacca accaaacaaa caaaacctta ctgcaagtca gaggctctga tagatacaag
     5881 aaggatcaag tatgtcagta aatgaaaaat aaaataaaaa ggaaggacat gactgctctt
     5941 aggtatgctg gaggagaaag tttactcaga gtatccaagt tgtagccaaa gatgagattt
     6001 cacgcgtcac gtaaccctcc ttactcgtcc ctgcctctaa gcccttgctg tccctccccc
     6061 atccgtgcat gattttacta ccttgcttca tgtcaatttt ttttcaggct caatttaaac
     6121 tctcctccca atgactctcc tgggctaaga tgattccttc ctctcctccc tcatccatgt
     6181 actaattgat gtcaaataag ctgaggcagc ctagcaagca cattgtatac atttacacac
     6241 acacacacac acacacacac acacacacgt atatgtatat atatatatgt atatatatat
     6301 atatacacat gcacaatatg atgtatatgt agtatatgta tatgcatatg tatacacaca
     6361 tataaacaga aacttagatg gatgataatt ataaattcac attcaatgtc actatcaggt
     6421 tggataatta tctttgggaa agtttaaaac aagctcaatg tatttaagta ataaaaaaat
     6481 aaactccaga tccttgggtg gatgtgatat gggttggctg ggtgcccctg cctgggtcca
     6541 tctgtctgca aggtgatcct tactgtatgc tttcaatcac ggctatgtga gaggctgagg
     6601 cacaaagatc acatttcaga tcctgcctgg acttcagagt aacttcaagg ccaaccctta
     6661 caagatccta ttcaagattg gaaaatgaag ggggttagga actagagata cagattcacg
     6721 gcagattgcc tgtctaacac ataggagacc acagactcaa cccttaataa gcacaaaaat
     6781 aaaaaatcaa aaaccaaaga gagaccacag ggacgattcc tttccttaca ctgtgggact
     6841 gtttcctgga taacctacat cactcagttt gggtcacttt tgcctatgag cagacagcat
     6901 ataaaccgtt acttctcctt cctcattaca tctgagctgg ggaagagtag gatggctgga
     6961 agcagccatg agggcaccac agtctagact aaaattctcc tttagtgctt cacttaattt
     7021 gccacgaggg agccattcct cctaccaagg actaagcacg ccagcatccc tgtatcctct
     7081 tagagccatc taaatgatat tcttcactgt ggcaggccat ggaggaactg gtggaccagg
     7141 ggctggtgaa agctctgggc atctccaact tcaaccactt ccagattgaa aggctcctga
     7201 acaagcctgg actaaaacat aagccagtga ccaaccaggt aagttctgtt tggggtgggt
     7261 cctgctctgt gcctgcttca gcactgggag gcagagtctc ctctcagagg tctatgttca
     7321 ggatgcttag ggaggtggga ggcaggtctc tgggtctggt ttgtagcata catacctgtc
     7381 catgggttgt gtttggcctt tgtgttggtc ctttcatgtg tatggagttc ctgctgagcc
     7441 attcaggaag acctccttcc ctagagatgg tgatgtttgt tttttttttt tttttttttg
     7501 tttttttttt ttttttgttt tctcttgcag attgagagcc acccttatct cacccaggaa
     7561 aaactgatcc aatactgtca atccaagggc atcgctgtta cagcctacag tcccctgggc
     7621 tccccagaca ggccttagta aggcttcagc atactggttc tttctttttt tttttttatc
     7681 cttcttaaaa ttagcatttt gtaatttgtt ctattagtat gtaagttcca aggcacaaga
     7741 taaatatacc aatggcaatg tgttggtaac ccaagtggga ttgtcagggt aaagtgtttt
     7801 taaaatgata gcatgtctga tcccctggaa tattccattt ctgatgtcct gtgctggggc
     7861 agtattttca aattgccaaa gtactagatc ctatgcacga atccaggggg aaagatcttc
     7921 ctgcctgcct tgcagaggaa aaatgctgca gtgctcagcc ttgatgctgt cctggcaggg
     7981 atgttcacgg gcacacagta gccatggtga tttttactcc agctctcttt cttcgtctag
     8041 tgccaagcca gaagaccccg tagtaatgga gattcccaag atcaaagaga ttgctgcaaa
     8101 acacaagaaa acagtagctc aggtaaaata aagtatttcc cccttttatt tagcaatcca
     8161 gtcttgtagt catgtgtaca actgtgttgc ttgctttaaa ttccctggag aggaagaaat
     8221 gggaagtgta agccctgaag ggagcttcag aaaataccgc tagcattagt gaagcaagga
     8281 tctgcctctg tctttcagat tcctgccaca cctcaggcgt tgggttcaag cgccaactat
     8341 atagggtcta agccctattg actacaggct actctcctca ctcctcgtta ggaattccta
     8401 gttgtttctt ggatcaaggg gcataagaag ggaactggaa aagtatccct aatggtgaag
     8461 ggctttgtta atatcaactg ttgttaagcc agttacttag ttgtcatctt acaagaagga
     8521 gaaggtcttg tagctaactg ggcacatgcc ttcccttcgt aatacacagg ttctgattcg
     8581 gttccatgtc caaaggaatg tggtggtgat ccccaagtct gtgacaccct cacgcataca
     8641 ggagaacctg caggtaagac ctgggctgta catctgacat tcctcagtgg aacaggtgat
     8701 aggagggaag gaggactctt cttccctgcc cttcagcttc tcatcccact ctttcactga
     8761 cagtgtgtct tcccttcttc caagcactct gtcaacttgt aggctagaaa gctgggatga
     8821 ctgagctcac aggtggtacc ggccaaacct gtcaggactg atcacaactg tagcttatat
     8881 cactgagatg accatgccta ccattgagca cttagatcat aggtggaatg ctgtgctagc
     8941 caactgaaga ctgccttgta gacatggact ggacttgaaa acttgtcctc tgagacacct
     9001 tcaggccata catacttagc acacctacac ccaatctctt ccctcttaga acactaaact
     9061 ctataaataa ctcactctta atttagagaa taatgtattg tcatggacat attagggaaa
     9121 cacctcagat ccctccgagc actttccttg ctaaggtgtt ttggaactct tgtctttcta
     9181 ggtcttcgac ttccagttga gtgaggagga catggctgcc attctcagct tcaacaggaa
     9241 ctggagggcc tgtgacctgt tggagtaagt ggtaccaggt taagtaggag gttgattagg
     9301 cctctcccta agggtaaagg gttagtagga agggatggaa ggcatgtggg attatgggat
     9361 ggtttttgtc ttcaaatact attttctggc agttgtgaaa agttaaaaag aaaagtctga
     9421 gtcctgggga ctcactaagg gcagagacat tgtcatctga tgctcagttt ctgaatctta
     9481 cacacagagt gaggatttta aagaaaggag ctgtcactgc tgtgtgggag tcaagttctc
     9541 cttccctcac tcattcaccc agtgacttcc tgtaatgtgc tatggccatt catggtctac
     9601 atgtttggga catcacacaa taagcttcct gttcccaagc tcatattcta cagaggacaa
     9661 ctgaagtaac tctgatctca gttacataca ccaatcagag agtgacaaat accatataga
     9721 aaagtgaagc aggacaaaag gtatacgtgc cctttgtaat agacacttta atacatgact
     9781 atccagggga agctttgttc aaaaagtggc agttgaagac agtggaagat gagtaacatg
     9841 gctatttagg gaaatagcat tcttgcaatc atagcaacca ttgcagatgc tctgctctcg
     9901 tagctagagc atttgaatgg gattgagaat actgtggaat gaataagtgt tattgtaaga
     9961 acgcagaaac ttgaggagat ttaggttaag gctatggaca ggcctttgat ttttaggcct
    10021 gaaagaggaa taagccatga acagagctgg tatgatccga tgtgtcttaa aaggctcaca
    10081 atgacttgtg ggttgagaga ctagcacagt aacccatgga aaagatgaca gtcgttggac
    10141 ctggaccatg gtgttgggga ggagatgagg aagaccacca tctagataaa tgggaacatg
    10201 caatcaattt agtttcctcc tcaaaattta cagttgaagc tggttttgta tttttgtttg
    10261 cgtggttggc ttttgtttga gcaactcaca tgcagaatta acattttggt aaaatcaagg
    10321 gtttgacatg cgtttattat gcctgttggg tatcaactag gagtatatgt gaagctagtg
    10381 aatttggtga cctcagaagc caactgtcac tgggttctaa tccaaaatct actacttatt
    10441 cactagcact ggggcccttg gggagttttg gtgatgttct aaaatcactt ttctaatcta
    10501 caaagtaagg atgacaatat taatcacagc caaccttcac tgaattctct cgtttagcat
    10561 gcagcagcaa ctttaagccc tttgcttata ttagtatcat atttactact catacccaat
    10621 ctattgattt caatagtatt tcctgcttca cagcaatgcc agagtttgga caatagttct
    10681 ggggccctta gttgtgtgtc tgcttgttta tgatccctta agatatcaat gaactggtga
    10741 ccgagtgact gatagctcgc aggccttcct tccttaatac tcctctgata ttttgggaga
    10801 aggtccttgt gtgcccgcgc cacactccat gtcccatgtt cacagtcttg ttgggggaag
    10861 agatcagaag agtacagaaa tagctgaata tatcacgtaa gagtgtctca gatcacattt
    10921 gattctgtgg actgttttct tctttgtatt tgttgttgca gtgcaaggac tgaagaggac
    10981 tatcctttcc acgaggaata ctgaggtcca cttgcttgat gagatc
//