From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human endothelial leukocyte adhesion molecule I (ELAM-1) mRNA,
Date: 10 Apr 92 10:05:54 GMT
Distribution: bionet
Checksum: 20527     8

LOCUS       HUMELAMA1A   3856 bp ss-mRNA            PRI       10-APR-1992
DEFINITION  Human endothelial leukocyte adhesion molecule I (ELAM-1) mRNA,
            complete cds.
ACCESSION   M30640
KEYWORDS    endothelial leukocyte adhesion molecule I.
SOURCE      Human umbilical vein endothelial cells, cDNA to mRNA, clones EL1 6,
            pSQ148, and pSQ149.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Hession,C., Osborn,L., Goff,D., Chi-Rosso,G., Vassallo,C.,
            Pasek,M., Pittack,C., Tizard,R., Goelz,S., McCarthy,K., Hopple,S.
            and Lobb,R.
  TITLE     Endothelial leukocyte adhesion molecule 1: Direct expression
            cloning and functional interactions
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87, 1673-1677 (1990)
  STANDARD  full staff_review
COMMENT     Draft entry and printed sequence for [1] kindly submitted by
            C.Hession, 12-DEC-1989.
FEATURES             Location/Qualifiers
     CDS             141..1973
                     /note="precursor"
                     /product="endothelial leukocyte adhesion molecule I"
                     /gene="ELAM1"
                     /codon_start=1
                     /translation="MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRY
                     THLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEP
                     NNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINN
                     YTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS
                     METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF
                     ELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFT
                     CEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGS
                     SCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE
                     FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSG
                     EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGL
                     SLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL"
     sig_peptide     141..203
                     /gene="ELAM1"
                     /codon_start=1
     mat_peptide     204..1970
                     /product="endothelial leukocyte adhesion molecule I"
                     /gene="ELAM1"
                     /codon_start=1
BASE COUNT     1149 a    776 c    853 g   1078 t
ORIGIN
        1 ttcacatcaa aactcctata ctgacctgag acagaggcag cagtgatacc cacctgagag
       61 atcctgtgtt tgaacaactg cttcccaaaa cggaaagtat ttcaagccta aacctttggg
      121 tgaaaagaac tcttgaagtc atgattgctt cacagtttct ctcagctctc actttggtgc
      181 ttctcattaa agagagtgga gcctggtctt acaacacctc cacggaagct atgacttatg
      241 atgaggccag tgcttattgt cagcaaaggt acacacacct ggttgcaatt caaaacaaag
      301 aagagattga gtacctaaac tccatattga gctattcacc aagttattac tggattggaa
      361 tcagaaaagt caacaatgtg tgggtctggg taggaaccca gaaacctctg acagaagaag
      421 ccaagaactg ggctccaggt gaacccaaca ataggcaaaa agatgaggac tgcgtggaga
      481 tctacatcaa gagagaaaaa gatgtgggca tgtggaatga tgagaggtgc agcaagaaga
      541 agcttgccct atgctacaca gctgcctgta ccaatacatc ctgcagtggc cacggtgaat
      601 gtgtagagac catcaataat tacacttgca agtgtgaccc tggcttcagt ggactcaagt
      661 gtgagcaaat tgtgaactgt acagccctgg aatcccctga gcatggaagc ctggtttgca
      721 gtcacccact gggaaacttc agctacaatt cttcctgctc tatcagctgt gataggggtt
      781 acctgccaag cagcatggag accatgcagt gtatgtcctc tggagaatgg agtgctccta
      841 ttccagcctg caatgtggtt gagtgtgatg ctgtgacaaa tccagccaat gggttcgtgg
      901 aatgtttcca aaaccctgga agcttcccat ggaacacaac ctgtacattt gactgtgaag
      961 aaggatttga actaatggga gcccagagcc ttcagtgtac ctcatctggg aattgggaca
     1021 acgagaagcc aacgtgtaaa gctgtgacat gcagggccgt ccgccagcct cagaatggct
     1081 ctgtgaggtg cagccattcc cctgctggag agttcacctt caaatcatcc tgcaacttca
     1141 cctgtgagga aggcttcatg ttgcagggac cagcccaggt tgaatgcacc actcaagggc
     1201 agtggacaca gcaaatccca gtttgtgaag ctttccagtg cacagccttg tccaaccccg
     1261 agcgaggcta catgaattgt cttcctagtg cttctggcag tttccgttat gggtccagct
     1321 gtgagttctc ctgtgagcag ggttttgtgt tgaagggatc caaaaggctc caatgtggcc
     1381 ccacagggga gtgggacaac gagaagccca catgtgaagc tgtgagatgc gatgctgtcc
     1441 accagccccc gaagggtttg gtgaggtgtg ctcattcccc tattggagaa ttcacctaca
     1501 agtcctcttg tgccttcagc tgtgaggagg gatttgaatt acatggatca actcaacttg
     1561 agtgcacatc tcagggacaa tggacagaag aggttccttc ctgccaagtg gtaaaatgtt
     1621 caagcctggc agttccggga aagatcaaca tgagctgcag tggggagccc gtgtttggca
     1681 ctgtgtgcaa gttcgcctgt cctgaaggat ggacgctcaa tggctctgca gctcggacat
     1741 gtggagccac aggacactgg tctggcctgc tacctacctg tgaagctccc actgagtcca
     1801 acattccctt ggtagctgga ctttctgctg ctggactctc cctcctgaca ttagcaccat
     1861 ttctcctctg gcttcggaaa tgcttacgga aagcaaagaa atttgttcct gccagcagct
     1921 gccaaagcct tgaatcagat ggaagctacc aaaagccttc ttacatcctt taagttcaaa
     1981 agaatcagaa acaggtgcat ctggggaact agagggatac actgaagtta acagagacag
     2041 ataactctcc tcgggtctct ggcccttctt gcctactatg ccagatgcct ttatggctga
     2101 aaccgcaaca cccatcacca cttcaataga tcaaagtcca gcaggcaagg acggccttca
     2161 actgaaaaga ctcagtgttc cctttcctac tctcaggatc aagaaagtgt tggctaatga
     2221 agggaaagga tattttcttc caagcaaagg tgaagagacc aagactctga aatctcagaa
     2281 ttccttttct aactctccct tgctcgctgt aaaatcttgg cacagaaaca caatattttg
     2341 tggctttctt tcttttgccc ttcacagtgt ttcgacagct gattacacag ttgctgtcat
     2401 aagaatgaat aataattatc cagagtttag aggaaaaaaa tgactaaaaa tattataact
     2461 taaaaaatga cagatgttga atgcccacag gcaaatgcat ggagggttgt taatggtgca
     2521 aatcctactg aatgctctgt gcgagggtta ctatgcacaa tttaatcact ttcatcccta
     2581 tgggattcag tgcttcttaa agagttctta aggattgtga tatttttact tgcattgaat
     2641 atattataat cttccatact tcttcattca atacaagtgt ggtagggact taaaaaactt
     2701 gtaaatgctg tcaactatga tatggtaaaa gttacttatt ctagattacc ccctcattgt
     2761 ttattaacaa attatgttac atctgtttta aatttatttc aaaaagggaa actattgtcc
     2821 cctagcaagg catgatgtta accagaataa agttctgagt gtttttacta cagttgtttt
     2881 ttgaaaacat ggtagaattg gagagtaaaa actgaatgga aggtttgtat attgtcagat
     2941 attttttcag aaatatgtgg tttccacgat gaaaaacttc catgaggcca aacgttttga
     3001 actaataaaa gcataaatgc aaacacacaa aggtataatt ttatgaatgt ctttgttgga
     3061 aaagaataca gaaagatgga tgtgctttgc attcctacaa agatgtttgt cagatatgat
     3121 atgtaaacat aattcttgta tattatggaa gattttaaat tcacaataga aactcaccat
     3181 gtaaaagagt catctggtag atttttaacg aatgaagatg tctaatagtt attccctatt
     3241 tgttttcttc tgtatgttag ggtgctctgg aagagaggaa tgcctgtgtg agcaagcatt
     3301 tatgtttatt tataagcaga tttaacaatt ccaaaggaat ctccagtttt cagttgatca
     3361 ctggcaatga aaaattctca gtcagtaatt gccaaagctg ctctagcctt gaggagtgtg
     3421 agaatcaaaa ctctcctaca cttccattaa cttagcatgt gttgaaaaaa aagtttcaga
     3481 gaagttctgg ctgaacactg gcaacaacaa agccaacagt caaaacagag atgtgataag
     3541 gatcagaaca gcagaggttc ttttaaaggg gcagaaaaac tctgggaaat aagagagaac
     3601 aactactgtg atcaggctat gtatggaata cagtgttatt ttctttgaaa ttgtttaagt
     3661 gttgtaaata tttatgtaaa ctgcattaga aattagctgt gtgaaatacc agtgtggttt
     3721 gtgtttgagt tttattgaga attttaaatt ataacttaaa atattttata atttttaaag
     3781 tatatattta tttaagctta tgtcagacct atttgacata acactataaa ggttgacaat
     3841 aaatgtgctt atgttt
//