From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens alpha-2 strychnine binding subunit of inhibitory glycine
Date: 3 Jan 93 22:06:33 GMT
Distribution: bionet
Checksum: 14109 5

LOCUS       HUMGLYRA2    1715 bp ss-RNA             PRI       21-DEC-1992
DEFINITION  H.sapiens alpha-2 strychnine binding subunit of inhibitory glycine
            receptor mRNA
ACCESSION   X52009
KEYWORDS    glycine receptor; inhibitory glycine receptor; strychnine binding.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Grenningloh,G., Schmieden,V., Schofield,P.R., Seeburg,P.H.,
            Siddique,T., Mohandas,T.K., Becker,C.M. and Betz,H.
  TITLE     Alpha subunit variants of the human glycine receptor: primary
            structures, functional expression and chromosomal localization of
            the corresponding genes
  JOURNAL   EMBO J. 9, 771-776 (1990)
  STANDARD  full automatic
COMMENT     *source: stage=fetal; *source: tissue=brain; *source: chromosome=X;
            *source: map_position=Xp21.2-p22.1;
               From EMBL    entry HSGLYRA2;  dated 17-DEC-1992.
FEATURES             Location/Qualifiers
     CDS             297..1646
                     /gene="GLYRA2"
                     /note="strychnine binding alpha-2 subunit"
                     /product="inhibitory glycine receptor"
                     /codon_start=1
                     /translation="MYSFNTLRLYLSGAIVFFSLAASKEAEAARSATKPMSPSDFLDK
                     LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLA
                     YNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRI
                     TLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILK
                     EEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDA
                     APARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF
                     VSRQHKELLRFRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTN
                     PPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ"
BASE COUNT      424 a    480 c    407 g    404 t
ORIGIN      
        1 cgggaggcaa cagacacgct ggagtttaac aaacagcaat actcttcgcg ctcctgaaaa
       61 gcaggtctgg acgctctccg tggtgctgaa acgcctcgca gccgccgctg tccgtggtat
      121 ctacgacccc ctcgctccaa tttcccctgg ggctctccct ccgcgcccct gttccccgcc
      181 tccctttaac atctggatta ttttttgcaa tagcgctttc tggttttgta agtgccaatt
      241 tgaaacattt tttgccccca taactcgtgg actacaaagc acaaaggacc tgaaaaatgt
      301 acagcttcaa tactcttcga ctctaccttt cgggagccat tgtattcttc agccttgctg
      361 cttctaagga ggctgaagct gctcgctccg caaccaagcc tatgtcaccc tcggatttcc
      421 tggataagct aatggggaga acctccggat atgatgccag gatcaggccc aattttaaag
      481 gtcccccagt gaacgtgagc tgcaacattt tcatcaacag ctttggttcc attgctgaga
      541 caaccatgga ctatagggtc aacatcttcc tgcggcagca atggaacgac ccccgcctgg
      601 cctataatga ataccctgac gactctctgg acctggaccc atccatgctg gactccatct
      661 ggaaacctga cctgttcttt gccaacgaga agggggccca cttccatgag atcaccacag
      721 acaacaaatt gctaaggatc tcccggaatg ggaatgtcct ctacagcatc agaatcaccc
      781 tgacactggc ctgccccatg gacttgaaga atttccccat ggatgtccag acatgtatca
      841 tgcaactgga aagctttgga tatacgatga atgacctcat ctttgagtgg caggaacagg
      901 gagccgtgca ggtagcagat ggactaactc tgccccagtt tatcttgaag gaagagaagg
      961 acttgagata ctgcaccaag cactacaaca caggtaaatt cacctgcatt gaggcccggt
     1021 tccacctgga gcggcagatg ggttactacc tgattcagat gtatattccc agcctgctca
     1081 ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct gctcgtgtgg
     1141 gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct cgagcatctc
     1201 tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc ctgctctttg
     1261 tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa cataaggagc
     1321 tgctccgatt caggaggaag cggagacatc acaaggagga tgaagctgga gaaggccgct
     1381 ttaacttctc tgcctatggg atgggcccag cctgtctaca ggccaaggat ggcatctcag
     1441 tcaagggcgc caacaacagt aacaccacca acccccctcc tgcaccatct aagtccccag
     1501 aggagatgcg aaaactcttc atccagaggg ccaagaagat cgacaaaata tcccgcattg
     1561 gcttccccat ggccttcctc attttcaaca tgttctactg gatcatctac aagattgtcc
     1621 gtagagagga cgtccacaac cagtgaaggg tctgaaaggt tgggggaggc tgggagaggg
     1681 gaacgtggga atagcacagg aatctgagag acggt
//