From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human proteinase 3 gene, exon 5 and cds (3' end).
Date: 31 Dec 92 01:37:39 GMT
Distribution: bionet
Checksum: 36275 4

LOCUS       HUMPRT3A03    425 bp ds-DNA             PRI       17-DEC-1992
DEFINITION  Human proteinase 3 gene, exon 5 and cds (3' end).
ACCESSION   M96839
KEYWORDS    proteinase 3.
SEGMENT     3 of 3
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Bories,D., Raynal,M.-C., Solomon,D.H., Darzynkiewicz,Z. and
            Cayre,Y.E.
  TITLE     Down-regulation of a serine protease, myeloblastin, causes growth
            arrest and differentiation of promyelocytic leukemia cells
  JOURNAL   Cell 59, 959-968 (1989)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Campanelli,D., Melchior,M., Fu,Y., Nakata,M., Shuman,H., Nathan,C.
            and Gabay,J.E.
  TITLE     Cloning of cDNA for proteinase 3: a serine protease, antibiotic,
            and autoantigen from human neutrophils
  JOURNAL   J. Exp. Med. 172, 1709-1715 (1990)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 425)
  AUTHORS   Zimmer,M., Medcalf,R.L., Fink,T.M., Mattmann,C., Lichter,P. and
            Jenne,D.E.
  TITLE     Three human elastase-like genes co-ordinately expressed in the
            myelo-monocyte lineage are organized as a single genetic locus on
            19pter
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 8215-8219 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     intron          <1..20
                     /number=4
                     /label=intron4
     exon            21..>397
                     /number=5
                     /label=exon5
     conflict        replace(183..185,"")
                     /citation=[2]
                     /note="'' in conflict"
     conflict        replace(274,"")
                     /citation=[1]
                     /note="'G' in conflict"
     conflict        replace(292..298,"")
                     /citation=[2]
                     /note="'TGG' in conflict"
     conflict        replace(326,"")
                     /citation=[2]
                     /note="'' in conflict"
     polyA_signal    380..385
                     /label=polyA_signal
     polyA_site      397
                     /citation=[2]
     CDS             join(M96838:540..705,M96838:972..1113,M96837:246..476,
                     21..191)
                     /partial
                     /codon_start=3
                     /translation="AARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSF
                     VLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQ
                     LSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFF
                     CRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALY
                     VDWIRSTLRRVEAKGRP"
BASE COUNT       68 a    165 c    111 g     81 t
ORIGIN      
        1 tggccgtccc tgtcctccag ggagactcag gtggccccct gatctgtgat ggcatcatcc
       61 aaggaataga ctccttcgtg atctggggat gtgccacccg ccttttccct gacttcttca
      121 cgcgggtagc cctctacgtg gactggatcc gttccacgct gcgccgtgtg gaggccaagg
      181 gccgcccctg aaccgcccct cccacagcgc tggccgggac cccgagcctg gctccaaacc
      241 ctcgaggcgg atctttggac agaagcagct cttccccgaa cactgtggcg tccgggacgg
      301 ccccacccgt ccccccacac tccctcccac ggggctccgg gagacaggcc ggccctgcac
      361 ctcaccccac cgtgacctca ataaacgttg aaactcccct ggctcctgtc tgtccttcct
      421 atagg
//