From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human high density lipoprotein binding protein (HBP) mRNA, complete
Date: 25 Jul 92 10:03:36 GMT
Distribution: bionet
Checksum: 15982     9

LOCUS       HUMHBP       4354 bp ss-mRNA            PRI       25-JUL-1992
DEFINITION  Human high density lipoprotein binding protein (HBP) mRNA, complete
            cds.
ACCESSION   M64098
KEYWORDS    HX protein homologue; high density lipoprotein binding protein;
            tandem amphipathic repeat.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4354)
  AUTHORS   McKnight,G.L., Reasoner,J., Gilbert,T., Sundquist,K.O., Hokland,B.,
            McKernan,P.A., Champagne,J., Johnson,C.J., Bailey,M.C., Holly,R.,
            O'Hara,P.J. and Oram,J.F.
  TITLE     cloning and expression of a cellular high density
            liporotein-binding protein that is up-regulated by cholesterol
            loading of cells
  JOURNAL   J. Biol. Chem. 267, 12131-12141 (1992)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     CDS             155..3961
                     /product="high density lipoprotein binding protein"
                     /gene="HBP"
                     /codon_start=1
                     /translation="MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAF
                     PPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAK
                     ICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKE
                     HHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAE
                     QDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQ
                     LAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPS
                     DSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQ
                     QMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
                     IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENER
                     TKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKC
                     TKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNS
                     ETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEE
                     CGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHK
                     FLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLD
                     NVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCV
                     EAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREE
                     NAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVP
                     VTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRA
                     KAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQF
                     PDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGAR
                     GKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDS
                     EALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPKTL
                     PWGPKR"
BASE COUNT     1209 a   1124 c   1180 g    841 t
ORIGIN
        1 gaattcgggg ggcgagtaag ccagcggcag gaccagcggg cgggggccac aacaaaagct
       61 ggcaggctga cagaggcggc ctcaggacgg accttctggc tactgaccgt tttgctgtgg
      121 ttttcccgga ttgtgtgtag gtgtgagatc aaccatgagt tccgttgcag ttttgaccca
      181 agagagtttt gctgaacacc gaagtgggct ggttccgcaa caaatcaaag ttgccactct
      241 aaattcagaa gaggagagcg accctccaac ctacaaggat gccttccctc cacttcctga
      301 gaaagctgct tgcctggaaa gtgcccagga acccgctgga gcctggggga acaagatccg
      361 acccatcaag gcttctgtca tcactcaggt gttccatgta cccctggagg agagaaaata
      421 caaggatatg aaccagtttg gagaaggtga acaagcaaaa atctgccttg agatcatgca
      481 gagaactggt gctcacttgg agctgtcttt ggccaaagac caaggcctct ccatcatggt
      541 gtcaggaaag ctggatgctg tcatgaaagc tcggaaggac attgttgcta gactgcagac
      601 tcaggcctca gcaactgttg ccattcccaa agaacaccat cgctttgtta ttggcaaaaa
      661 tggagagaaa ctgcaagact tggagctaaa aactgcaacc aaaatccaga tcccacgccc
      721 agatgacccc agcaatcaga tcaagatcac tggcaccaaa gagggcatcg agaaagctcg
      781 ccatgaagtc ttactcatct ctgccgagca ggacaaacgt gctgtggaga ggctagaagt
      841 agaaaaggca ttccacccct tcatcgctgg gccgtataat agactggttg gcgagatcat
      901 gcaggagaca ggcacgcgca tcaacatccc cccacccagc gtgaaccgga cagagattgt
      961 cttcactgga gagaaggaac agttggctca ggctgtggct cgcatcaaga agatttatga
     1021 ggagaagaaa aagaagacta caaccattgc agtggaagtg aagaaatccc aacacaagta
     1081 tgtcattggg cccaagggca attcattgca ggagatcctt gagagaactg gagtttccgt
     1141 tgagatccca ccctcagaca gcatctctga gactgtaata cttcgaggcg aacctgaaaa
     1201 gttaggtcag gcgttgactg aagtctatgc caaggccaat agcttcaccg tctcctctgt
     1261 cgccgcccct tcctggcttc accgtttcat cattggcaag aaagggcaga acctggccaa
     1321 aatcactcag cagatgccaa aggttcacat cgagttcaca gagggcgaag acaagatcac
     1381 cctggagggc cctacagagg atgtcaatgt ggcccaggaa cagatagaag gcatggtcaa
     1441 agatttgatt aaccggatgg actatgtgga gatcaacatc gaccacaagt tccacaggca
     1501 cctcattggg aagagcggtg ccaacataaa cagaatcaaa gaccagtaca aggtgtccgt
     1561 gcgcatccct cctgacagtg agaagagcaa tttgatccgc atcgaggggg acccacaggg
     1621 cgtgcagcag gccaagcgag agctgctgga gcttgcatct cgcatggaaa atgagcgtac
     1681 caaggatcta atcattgagc aaagatttca tcgcacaatc attgggcaga agggtgaacg
     1741 gatccgtgaa attcgtgaca aattcccaga ggtcatcatt aactttccag acccagcaca
     1801 aaaaagtgac attgtccagc tcagaggacc taagaatgag gtggaaaaat gcacaaaata
     1861 catgcagaag atggtggcag atctggtgga aaatagctat tcaatttctg ttccgatctt
     1921 caaacagttt cacaagaata tcattgggaa aggaggcgca aacattaaaa agattcgtga
     1981 agaaagcaac accaaaatcg accttccagc agagaatagc aattcagaga ccattatcat
     2041 cacaggcaag cgagccaact gcgaagctgc ccggagcagg attctgtcta ttcagaaaga
     2101 cctggccaac atagccgagg tagaggtctc catccctgcc aagctgcaca actccctcat
     2161 tggcaccaag ggccgtctga tccgctccat catggaggag tgcggcgggg tccacattca
     2221 ctttcccgtg gaaggttcag gaagcgacac cgttgttatc aggggccctt cctcggatgt
     2281 ggagaaggcc aagaagcagc tcctgcatct ggcggaggag aagcaaacca agagtttcac
     2341 tgttgacatc cgcgccaagc cagaatacca caaattcctc atcggcaagg ggggcggcaa
     2401 aattcgcaag gtgcgcgaca gcactggagc acgtgtcatc ttccctgcgg ctgaggacaa
     2461 ggaccaggac ctgatcacca tcattggaaa ggaggacgcc gtccgagagg cacagaagga
     2521 gctggaggcc ttgatccaaa acctggataa tgtggtggaa gactccatgc tggtggaccc
     2581 caagcaccac cgccacttcg tcatccgcag aggccaggtc ttgcgggaga ttgctgaaga
     2641 gtatggcggg gtgatggtca gcttcccacg ctctggcaca cagagcgaca aagtcaccct
     2701 caagggcgcc aaggactgtg tggaggcagc caagaaacgc attcaggaga tcattgagga
     2761 cctggaagct caggtgacat tagaatgtgc tataccccag aaattccatc gatctgtcat
     2821 gggccccaaa ggttccagaa tccagcagat tactcgggat ttcagtgttc aaattaaatt
     2881 cccagacaga gaggagaacg cagttcacag tacagagcca gttgtccagg agaatgggga
     2941 cgaagctggg gaggggagag aggctaaaga ttgtgacccc ggctctccaa ggaggtgtga
     3001 catcatcatc atctctggcc ggaaagaaaa gtgtgaggct gccaaggaag ctctggaggc
     3061 attggttcct gtcaccattg aagtagaggt gccctttgac cttcaccgtt acgttattgg
     3121 gcagaaagga agtgggatcc gcaagatgat ggatgagttt gaggtgaaca tacatgtccc
     3181 ggcacctgag ctgcagtctg acatcatcgc catcacgggc ctcgctgcaa atttggaccg
     3241 ggccaaggct ggactgctgg agcgtgtgaa ggagctacag gccgagcagg aggaccgggc
     3301 tttaaggagt tttaagctga gtgtcactgt agaccccaaa taccatccca agattatcgg
     3361 gagaaagggg gcagtaatta cccaaatccg gttggagcat gacgtgaaca tccagtttcc
     3421 tgataaggac gatgggaacc agccccagga ccaaattacc atcacagggt acgaaaagaa
     3481 cacagaagct gccagggatg ctatactgag aattgtgggt gaacttgagc agatggtttc
     3541 tgaggacgtc ccgctggacc accgcgttca cgcccgcatc attggtgccc gcggcaaagc
     3601 cattcgcaaa atcatggacg aattcaaggt ggacattcgc ttcccacaga gcggagcccc
     3661 agaccccaac tgcgtcactg tgacggggct cccagagaat gtggaggaag ccatcgacca
     3721 catcctcaat ctggaggagg aatacctagc tgacgtggtg gacagtgagg cgctgcaggt
     3781 atacatgaaa cccccagcac acgaagaggc caaggcacct tccagaggct ttgtggtgcg
     3841 ggacgcaccc tggaccgcca gcagcagtga gaaggctcct gacatgagca gctctgagga
     3901 atttcccagc tttggggctc aggtggctcc caagaccctc ccttggggcc ccaaacgata
     3961 atgatcaaaa agaacagaac cctctccagc ctgctgaccc gaacccaacc acacaatggt
     4021 ttgtctcaat ctgacccagc ggctggaccc tccgtaaatt gttgagcgct cttccccttc
     4081 ccgaggtccg cagggagcct agcgcctggc tgtgtgtgcg gccgctcctc caggcctggc
     4141 cgtgcccgct caggacctgc tccactgttt aacaataaac caaggtcatg agcattcgag
     4201 ctaagataac agactccagc tcctggtcca cccggcatgt cagtcagcac tctggccttc
     4261 atcacgagag ctccgcagcc gtggctagga ttccacttcc tgtgtcatga cctcaggaaa
     4321 taaacgtcct tgactttata aaagccccga attc
//