From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human unrearranged myc allele of SKW-3 oncogene, complete cds.
Date: 5 Nov 92 23:11:03 GMT
Distribution: bionet
Checksum: 02929 5

LOCUS       HUMMYCTR     2220 bp ds-DNA             PRI       15-JUN-1989
DEFINITION  Human unrearranged myc allele of SKW-3 oncogene, complete cds.
ACCESSION   J03253
KEYWORDS    Myc protein.
SOURCE      Human leukemia T-cell line SKW-3 DNA, clone lambda-SKW13.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Finver,S.N., Nishikura,K., Finger,L.R., Haluska,F.G., Finan,J.,
            Nowell,P.C. and Croce,C.M.
  TITLE     Sequence analysis of the MYC oncogene involved in the t(8;14) (q24;
            q11) chromosome translocation in a human leukemia T-cell line
            indicates that putative regulatory regions are not altered
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85, 3052-3056 (1988)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mutation        283..284
                     /note="cc in SKW13; cccc in SKW22 and myc"
     mutation        1234
                     /note="g in SKW13; t in SKW22 and myc"
     mutation        1403
                     /note="g in SKW13 and SKW22; c in myc"
     CDS             1574..2140
                     /gene="MYC"
                     /product="myc protein"
                     /codon_start=1
                     /translation="MRGSGRLRTPELCCSRPPPPGPGRPWLPSCLEKGRASQRLGGKK
                     NGGRDRAEYKSRFSGLYLTRCSNSSERQRERAGGRLGWKSRASRAALRASWEGRSGAN
                     RGLRLWPSPPADPPASGPQPLPHPRNFAHSSGRALCTGTYNTRARTRLSRRGEAILPI
                     WGHFPAAARTRFSERLSLQLLRRWIFFG"
BASE COUNT      508 a    616 c    603 g    493 t
ORIGIN      1664 bp upstream of XhoI site; chromosome 8q24.
        1 caaggatgag aagaatgttt tttgtttttc atgccgtgga ataacacaaa ataaaaaatc
       61 ccgagggaat atacattata tattaaatat agatcatttc agggagcaaa caaatcatgt
      121 gtggggctgg gcaactagct gatgcgaagc gtaaataaaa tgtgaataca cgtttgcggg
      181 ttacatacag tgcactttca ctagtattca gaaaaaattg tgagtcagtg aactaggaaa
      241 ttaatgcctg gaaggcagcc aaattttaat tagctcaaga ctcccccccc cccaaaaaaa
      301 ggcacggaag taatactcct ctcctcttct ttgatcagaa tcgatgcatt ttttgtgcat
      361 gaccgcattt ccaataataa aaggggaaag aggacctgga aaggaattaa acgtccggtt
      421 tgtccgggga ggaaagagtt aacggttttt ttcacaaggg tctctgctga ctcccccggc
      481 tcggtccaca agctctccac ttgccccttt taggaagtcc ggtcccgcgg ttcgggtacc
      541 ccctgcccct cccatattct cccgtctagc acctttgatt tctcccaaac ccggcagccc
      601 gagactgttg caaaccggcg ccacagggcg caaaggggat ttgtctcttc tgaaacctgg
      661 ctgagaaatt gggaactccg tgtgggaggc gtgggggtgg gacggtgggg tacagactgg
      721 cagagagcag gcaacctccc tctcgcccta gcccagctct ggaacaggca gacacatctc
      781 agggctaaac agacgcctcc cgcacggggc cccacggaag cctgagcagg cggggcagga
      841 ggggcggtat ctgctgcttt ggcagcaaat tgggggactc agtctgggtg gaaggtatcc
      901 aatccagata gctgtgcata cataatgcat aatacatgac tccccccaac aaatgcaatg
      961 ggagtttatt cataacgcgc tctccaagta tacgtggcaa tgcgttgctg ggttatttta
     1021 atcattctag gcatcgtttt cctccttatg cctctatcat tcctccctat ctacactaac
     1081 atcccacgct ctgaacgcgc gcccattaat acccttcttt cctccactct ccctgggact
     1141 cttgatcaaa gcgcggccct ttccccagcc ttagcgaggc gccctgcagc ctggtacgcg
     1201 cgtggcgtgg cggtgggcgc gcagtgcgtt ctcggtgtgg agggcagctg ttccgcctgc
     1261 gatgatttat actcacagga caaggatgcg gtttgtcaaa cagtactgct acggaggagc
     1321 agcagagaaa gggagagggt ttgagaggga gcaaaagaaa atggtaggcg cgcgtagtta
     1381 attcatgcgg ctctcttact ctgtttacat cctagagcta gagtgctcgg ctgcccggct
     1441 gagtctcctc cccaccttcc ccaccctccc ccaccctccc cataagcgcc cctcccgggt
     1501 tcccaaagca gagggcgtgg gggaaaagaa aaaagatcct ctctcgctaa tctccgccca
     1561 ccggcccttt ataatgcgag ggtctggacg gctgaggacc cccgagctgt gctgctcgcg
     1621 gccgccaccg ccgggccccg gccgtccctg gctcccctcc tgcctcgaga agggcagggc
     1681 ttctcagagg cttggcggga aaaagaacgg agggagggat cgcgctgagt ataaaagccg
     1741 gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga gggagcgagc
     1801 gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg cgtcctggga
     1861 agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg ctgatccccc
     1921 agccagcggt ccgcaaccct tgccgcatcc acgaaacttt gcccatagca gcgggcgggc
     1981 actttgcact ggaacttaca acacccgagc aaggacgcga ctctcccgac gcggggaggc
     2041 tattctgccc atttggggac acttccccgc cgctgccagg acccgcttct ctgaaaggct
     2101 ctccttgcag ctgcttagac gctggatttt tttcgggtag tggaaaacca ggtaagcacc
     2161 gaagtccact tgccttttaa tttatttttt tatcacttta atgctgagat gagtcgaatg
//