From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Oryctolagus cuniculus defensin NP-3a gene, complete cds.
Date: 12 Sep 92 10:03:15 GMT
Distribution: bionet
Checksum: 54190     7

LOCUS       RABDNP3AA    3090 bp ds-DNA             MAM       12-SEP-1992
DEFINITION  Oryctolagus cuniculus defensin NP-3a gene, complete cds.
ACCESSION   M64599
KEYWORDS    defensin; neutrophil specific.
SOURCE      Oryctolagus cuniculus (strain New Zealand white) male sperm DNA.
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Lagomorpha; Leporidae.
REFERENCE   1  (bases 1 to 3090)
  AUTHORS   Michaelson,D., Couto,M., Rayner,J.R. and Ganz,T.
  TITLE     Cationic defensins arise from charge-neutralized propeptides: a
            mechanism for avoiding leukocyte autocytotoxicity
  JOURNAL   J. Leukoc. Biol. 51, 634-639 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             order(1987..(2155.2156),2732..2844)
                     /product="defensin NP-3a"
                     /gene="defensin NP-3a"
                     /codon_start=1
                     /translation="MRTLILLAAILLAALQAQAELFSVNVDEVLDQQQPGSDQDLVIH
                     LTGEESSALQVPDTKGICACRRRFCPNSERFSGYCRVNGARYVRCCSRR"
     CAAT_signal     425..436
                     /gene="defensin NP-3a"
                     /note="putative"
     TATA_signal     628..634
                     /gene="defensin NP-3a"
                     /note="putative"
     exon            673..741
                     /number=1
                     /gene="defensin NP-3a"
                     /note="putative"
     intron          742..1973
                     /note="putative"
     exon            1974..2155
                     /number=2
                     /gene="defensin NP-3a"
                     /note="putative"
     sig_peptide     1987..2043
                     /gene="defensin NP-3a"
                     /codon_start=1
     intron          2156..2731
     exon            2732..2949
                     /number=3
                     /gene="defensin NP-3a"
                     /note="putative"
     mat_peptide     2740..2841
                     /function="immunological: neutrophil specific"
                     /product="defensin NP-3a"
                     /gene="defensin NP-3a"
                     /note="putative"
                     /codon_start=1
     polyA_site      2933..2939
                     /gene="defensin NP-3a"
BASE COUNT      844 a    739 c    631 g    876 t
ORIGIN
        1 agagctctca ctctgaagtc ttcctgagga atttgctggg tattttaagt cctcattcac
       61 caatctcaca ggtccttact agacaacatt tattgccagc ccatctatta ctgaagttag
      121 ataacattca ttccttctgg ggtacaacac acacttgata catccatagt ttagactcca
      181 gcaaaagggc accacacagt cacacatttc tcctctagtg caccatctac ctagtgtttt
      241 ccaacttcct caccctgcac aatgagcaga cctcaggtct tcaggaggtt ggacaatcgg
      301 attccaaatt ctctgagtgt gcattggtgt tttcaccctg ctcccttaac aaaaaatata
      361 ctataaaggg tgagcccatg gtttctagta gactttgata ttttcttgat ccaaaatatt
      421 cagcctgggc caatggccta ggcgtcacaa gaaaaaatag tgattgctgc ctaggcatgc
      481 acaaggctga ccaatacaga caagaagtcc tctgctgagc cccgttttaa cccagtttcc
      541 tgaaaaactg ccgaatggtc ctggccccag agttgattca attgcccaat aggaagtaaa
      601 cttaagaaat tttgagaaaa catctcgtta aatagaagtc ctgtgcagca gatgtgaggt
      661 ggctgctgct cctggagacc tgggtcagag gactgcttgc tgcgtgcctc tctctgatca
      721 tcccacaaag cctgtggatc tgtaagtact gaaaagctat cagctctcac ttggtggttg
      781 taccattgaa tctcagcagc aatctgaccc taaaggtgag tctacccagg aggaacccag
      841 gcgtgtactc cctgctgcag ctcttctgaa gggctcttgt ggctgctggg gacaagagct
      901 gccctgtgag ttaatagaga aaggtgaaat gatttgttcg aaacacaaat atcctactaa
      961 actcatccag tgaagacaac aacggcttct tcaggtgtgc ttctattttg ccaattgttt
     1021 tctaatcagg taatttattt tacgctattc agattttgct gtgatgctat tatttggata
     1081 ttaaccctta tcagatatcc cctgctgttt actagtttgc ttcttctgct gccgattgtt
     1141 tcctttgctc tgtagaagct tcacaattca atgcaacacc actgtccata ggcaagaaga
     1201 tccacatcaa gaaatttcat ctctatctga tcactgagta gttttatggt ttcaaggctt
     1261 gaatccactt tagtttaatt ttcctgtatg atttgagatg agggtacaat tttggataaa
     1321 tacatcagat tgtcagattg ggcactttct ttacacacaa ttttaaattg tcactgctgc
     1381 ttcaataaaa caggaaaaaa taaacactct cccatccttt gaccagttat ttctgtagta
     1441 ccaactgagt tcatttccac actatcagca gcaggaacct acccacccca taaccttaaa
     1501 atcctccttc aagacaatag aaagacctaa gcactgcagt gatcaactct ctactcacag
     1561 ggtccaggac tgggaacaga tttcagacct ttagagagca gcaggcccca tcttccaaaa
     1621 ataagaggca tttgctactt gatcttatta aatgagagca ctgcttcttc tccatcttga
     1681 atattaaagg catatgctcc aatgagcttg aaataggaaa atttagcaga gtcggcacaa
     1741 aaattttgag ccccagccca gaagagtcag taaacacaca gacttgtatt acattggggc
     1801 tgccagaaca gagaagcatc atgaggattt gagggcaatg gcagctctct ccctccctat
     1861 caaggtacac cttcccttcc agcagcaggg ttgtatctga gcctcctcta acagacccac
     1921 aaatacagac tgatgcctca ctgctcacac tgtcctgctc tcccatcctg caggtgcctc
     1981 ccggccatga ggaccctcat cctccttgct gccattctcc tggcggccct gcaggcccag
     2041 gctgagctct tctcagtaaa tgtcgatgag gttctagacc aacagcagcc agggtcggac
     2101 caggacctcg tcatccacct tacaggggag gaaagctctg ctcttcaagt tccaggtgag
     2161 agatgcaaca cagctgagct ggtagagact ccagggaatg aacagcacat ggactctgga
     2221 attgcctggg agagtaaccg agatgatttt tatttaacct tcctggctgg tgatattcaa
     2281 atctgtaaat tgaatactga aagccaaatg aatctgaggg tatcttttaa aaagactttt
     2341 gaatcagatt tgtgtgtgct attctcaggt tttatgacat ggagaggcac acggactagt
     2401 tggtcttatc taaataagta caattaatta taaggtgaat attgaactct aacaataaga
     2461 ggtttagaaa ctgaaatcag aagtaaggtt gtcttcatgt ctgtgtgtaa tggggtcaga
     2521 gcacatagaa gtgaacacag tgagaactgg tctcaggctc cacgtgtcca gcacttgctt
     2581 gtatgtttat tcctactgtt gggagttgcc catgctgctg gctatactgg agccaacttg
     2641 atgatcccac tcagtctaca tgcaacttct ccagcacgcc ttttggcacc cacctgtgac
     2701 tcagtgcctg acattttcct tgtgtcctca gatacaaagg gcatctgtgc ttgcagaaga
     2761 cgcttttgcc cgaattctga acgcttttcg gggtactgca gagtcaatgg agcccgctat
     2821 gtacgctgtt gcagcagaag atgaagaaca gaaaaacgga ttccttattt gcttttacaa
     2881 ttcaagggaa actgtttcca ctcctctgct atgtcctttg ctttcctacc ccaaataaaa
     2941 ttcttgaaga gaatgctctg catgtgcctc ctatgctgct tgcatgtatt ctagtctgat
     3001 ctgtttgaaa tgcaggaccc agaatcttaa attcttttaa acaaaagtct ggctccaaat
     3061 tccacacatc tgactgactt ggactcaggc
//