From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Aspergillus fumigatus major allergen I (Aspf1) gene, complete cds.
Date: 26 Jan 93 05:45:59 GMT
Distribution: bionet
Checksum: 60683 4

LOCUS       ASNALLIA      678 bp ds-DNA             PLN       25-JAN-1993
DEFINITION  Aspergillus fumigatus major allergen I (Aspf1) gene, complete cds.
ACCESSION   M83781
KEYWORDS    cytotoxin; major allergen I; mitogillin.
SOURCE      Aspergillus fumigatus spore DNA.
  ORGANISM  Aspergillus fumigatus
            Eukaryota; Fungi; Eumycota; Ascomycotina; Plectomycetes;
            Eurotiales; Trichocomaceae.
REFERENCE   1  (bases 1 to 678)
  AUTHORS   Arruda,L.K., Platts-Mills,T.A., Fox,J.W. and Chapman,M.D.
  TITLE     Aspergillus fumigatus allergen I, a major IgE-binding protein, is a
            member of the mitogillin family of cytotoxins
  JOURNAL   J. Exp. Med. 172, 1529-1532 (1990)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 678)
  AUTHORS   Arruda,L.K., Mann,B.J. and Chapman,M.D.
  TITLE     Selective expression of a major allergen and cytotoxin, Asp f I, in
            Aspergillus fumigatus. Implications for the immunopathogenesis of
            Aspergillus-related diseases
  JOURNAL   J. Immunol. 149, 3354-3359 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mat_peptide     join(141..143,196..639)
                     /product="major allergen I"
                     /gene="Aspf1"
                     /evidence="EXPERIMENTAL"
                     /codon_start=1
                     /citation=[1]
                     /note="sequence is identical to the 18 kDa sequence of
                     Lamy et al. (X58278)"
     exon            60..143
                     /number=1
                     /gene="Aspf1"
                     /partial
     sig_peptide     60..140
                     /gene="Aspf1"
                     /codon_start=1
                     /note="putative"
     intron          144..195
                     /number=1
     exon            196..642
                     /number=2
                     /gene="Aspf1"
                     /partial
     CDS             join(60..143,196..642)
                     /gene="Aspf1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
                     /note="sequence is identical to the 18 kDa sequence of
                     Lamy et al. (X58278)"
                     /product="major allergen I"
                     /codon_start=1
                     /translation="MVAIKNLFLLAATAVSVLAAPSPLDARATWTCINQQLNPKTNKW
                     EDKRLLYNQAKAESNSHHAPLSDGKTGSSYPHWFTNGYDGNGKLIKGRTPIKFGKADC
                     DRPPKHSQNGMGKDDHYLLEFPTFPDGHDYKFDSKKPKEDPGPARVIYTYPNKVFCGI
                     VAHQRGNQGDLRLCSH"
BASE COUNT      181 a    195 c    165 g    137 t
ORIGIN      
        1 tctcgtttgt cgcaaccaaa taggaagaca tcgtcacaat tgccctgact acgtccaaga
       61 tggttgcaat caaaaatctt ttcctgctgg ctgccacagc cgtgtctgtt ctagctgctc
      121 cctcgcccct cgacgctcgt gcggtaagag tcacatcgaa aggccttcga aaggatgact
      181 gacatgaccc cctagacctg gacatgcatc aaccaacagc tgaatcccaa gacaaacaaa
      241 tgggaagaca agcggcttct atacaatcaa gccaaagccg aaagcaactc ccaccacgca
      301 cctctttccg acggcaagac cggtagcagc tacccgcact ggttcactaa cggctacgac
      361 gggaatggca agctcatcaa gggtcgcacg cccatcaaat tcggaaaagc cgactgtgac
      421 cgtcccccga agcacagcca gaacggcatg ggcaaggatg accactacct gctggagttc
      481 ccaacttttc cagatggcca cgactataag tttgactcga agaaacccaa ggaagacccg
      541 ggcccagcga gggtcatcta tacttatccc aacaaggtgt tttgcggcat tgtggcccat
      601 cagcggggga atcagggaga cttgagactg tgttctcatt agttatgtgg gtattatgcc
      661 ttaggagggc gttgctgc
//