From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Lactococcus lactis operon (leuA, leuB, leuC, leuD, ilvD, ilvB,
Date: 6 Nov 92 18:30:48 GMT
Distribution: bionet
Checksum: 13135 24

LOCUS       LACLEUILV   12720 bp ds-DNA             BCT       02-NOV-1992
DEFINITION  Lactococcus lactis operon (leuA, leuB, leuC, leuD, ilvD, ilvB,
            ilvN, ilvC, ilvA) genes complete cds; complete ORF2.
ACCESSION   M90761
KEYWORDS    ilvA gene; ilvB gene; ilvC gene; ilvD gene; ilvN gene; leuA gene;
            leuB gene; leuC gene; leuD gene; operon.
SOURCE      Lactococcus lactis (library: NCDO2118) DNA.
  ORGANISM  Lactococcus lactis
            Prokaryotae; Firmicutes; Firmibacteria; Gram-positive cocci;
            Streptococcaceae.
REFERENCE   1  (bases 1 to 12720)
  AUTHORS   Godon,J.-J.J.-J., Chopin,M.-C.M. and Ehrlich,D.S.
  TITLE     Branched-chain amino acid biosythesis genes in Lactococcus lactis
            subup. lactis.
  JOURNAL   J. Bacteriol. 174, 6580-6589 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     attenuator      260..450
                     /note="putative"
     repeat_region   3039..3327
                     /function="unknown"
                     /rpt_type=DIRECT
                     /note="putative"
     CDS             450..1991
                     /EC_number="4.1.3.12"
                     /citation=[1]
                     /note="putative"
                     /gene="leuA"
                     /codon_start=1
                     /translation="MRKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEA
                     GFSAASPDSFEAVKQIADSLNDTAVTALARCVISDIDKAVEAVKGAKYPQIHVFIATS
                     PIHMKYKLKISPEEVLKNIDKCVRYARERVEVVEFSPEDATRTELNFLLEAVQTAVDA
                     GATYINIPDTVGYTTPEEYGKIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIK
                     AGAGRVEGTVNGIGERAGNAALEEIAVALHIRKDFYQAQSPLKLSETAATAELISQFS
                     GIAIPKNKAIVGANAFAHESGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRH
                     AFSEKLTELNIAYDDESLAILFEKFKKLADKKKEITDADIHALFTGETVKNLAGFILD
                     NVQIDGHKALVQLKNQEEEIYVSQGEGSGSVDAIFKAIDKVFNHQLKLISYSVDAVTD
                     GIDAQATTLVSVENLSTGTIFNAKGVDYDVLKGSAIAYMNANVLVQKENLQGKVEQIS
                     AHDGI"
     CDS             2003..3040
                     /note="putative"
                     /gene="leuB"
                     /codon_start=1
                     /translation="LSKKIVTLAGDGIGPEIMSAGLSVLKAVSKKIDFEYELEAKDFG
                     GIAIDKHGHPLPEETLQAVKNADAILLAAIGHPKYNNAKVRPEQGLLALRKELGLYAN
                     VRPLKIYPALKKLSPIRNVENVDFLVIRELTGGIYFGQHELADDKARDVNDYSADEIR
                     RILHFAFKSAQSRPRKLLTSVDKQNVLATSKLWRKMADEIADEYPDVRLEHQLVDSCA
                     MLLITNPQQFDVIVTENLFGDILSDEASSLAGSLGVMPSSSHGFNGLALYEPIHGSAP
                     DIAGKGIANPVSMILSIAMMLRESFGQEDGAAMIEKAVTQTFTDGILTKDLGGTATTK
                     EMTEAILKNCQ"
     CDS             3403..4785
                     /note="putative"
                     /gene="leuC"
                     /codon_start=1
                     /translation="MSGKTIFDKLWDQHVIAGNEGEPQLLYIDLHVIHEVTSPQAFQG
                     LREAGRRVRRKDLTYGTLDHNVPTQNIFNIQDLISKKQIDTFTKNVKEFDVPAETHGG
                     KGQGIVHMVAPESGRTQPGKTIVCGDSHTATNGAFGAIAFGIGTSEVEHVLATQTIWQ
                     VKPKRMKIEFQGHPQKGIYSKDFILALIAKYGVDAGVGYAVEYSGDAISDLSMEERMT
                     ICNMSIEFGAKIGLMNPDEKTYDYVKGREHAPKNFDEAVSKWEKLVSDSDAQYDKILS
                     LDVSQLKPMVTWGTNPGMGLEFGEKFPEINNDLNYERAYQYMDLKPGQTASDIDLGYI
                     FIGSCTNARLGDLEEAAKIIGDRHIADGLTGIVVPGSRPVKEAAEAQGLDKIFKEAGF
                     EWREPGCSACLGMNPDQIPEYVHCASTSNRNFEGRQGHNARTHLCSPAMAAAAAIAGK
                     FVDVRMLVTD"
     CDS             4805..5380
                     /note="putative"
                     /gene="leuD"
                     /codon_start=1
                     /translation="MEKFTIYKGTSVPVMNDNIDTDQIIPKQFLKAIDKKGFGKNLFY
                     EWRYLKDYDENPDFILNAPKYKKASLLISGDNFGSGSSREHAAWALSDYGFRAIIAGS
                     YSDIFYNNALKNGLLPIKQPREVLNQLTKLSSQEEITIDLPHQLIITSLGDFHFEIDP
                     IWKDKLINGLDDIGITLQYEEAISAYEQKNQ"
     CDS             5394..6173
                     /function="unknown"
                     /note="ORF2"
                     /note="putative"
                     /codon_start=1
                     /translation="MTIINLKNVNLTRNKKEILKDITWKVNPGENWVILGLNGSGKSS
                     LLKLILAEEWKTSGEITVLNTQFRNGEIPKLRKRISVVGSFIAERFQPNIKAENLVYT
                     GKFNSSMLYKPYTDQELDEARQLLRQMGAKSLIGRNYASLSQGEKQVLLIARSLILKP
                     ELLILDEATNGLDLFAKEKLLKQLQQINQLKTAPTLIYISHHPDEITDIFTHLLLLRE
                     GKVIQSGKKENLLNEKILTDFYQEKVEVHRFEQKYFVIPAN"
     CDS             6295..8007
                     /note="putative"
                     /gene="ilvD"
                     /codon_start=1
                     /translation="MEFKYNGKVESVELNKYSKTLTPRSTQPATQAMYYGIGFKDEDF
                     KKAQVGIVSMDWDGNPCNMHLGTLGSKIKSSVNQTDGLIGLQFHTIGVSDGIANGKLG
                     MRYSLVSREVIADSIETNAGAEYYDAIVAIPGCDKNMPGSIIGMARLNRPSIMVYGGT
                     IEHGEYKGEKLNIVSAFEALGQKITGNISDEDYHGVICNAIPGQGACGGMYTANTLAA
                     AIETLGMSLPYSSSNPAVSQEKQEECDDIGLAIKNLLEKDIKPSDIMTKEAFENAITI
                     VMVLGGSTNAVLHIIAMANAIGVEITQDDFQRISDIIPVLGDFKPSGKYMMEDLHKIG
                     GLPAVLKYLLKEGKLHGDCLTVTGKTLAENVETALDLDFDSQDIMRPLKNPIKATGHL
                     QILYGNLAQGGSVAKISGKEGEFFKGTARVFDGEQHFIDGIESGRLHAGDVAVIRNIG
                     PVGGPGMPEMLKPTSALIGAGLGKSCALITDGRFSGGTHGFVVGHIVPEAVEGGLIGL
                     VEDDDIIEIDAVNNSISLKVSNEEIAKRRANYQKPTPKATRGVLAKFAKLTRPASEGC
                     VTDL"
     CDS             8018..9745
                     /note="putative"
                     /gene="ilvB"
                     /codon_start=1
                     /translation="MKKIKLEKPTSGSQLVLQTLKELGVEIIFGYPGGAMLPLYDAIH
                     NFEGIQHILARHEQGATHEAEGYAKSSGKVGVVVVTSGPGATNAVTGIADAYLDSVPL
                     LVFTGQVGRQSIGKDAFQEADTVGITAPITKYNYQIRETADIPRIVTEAYYLARTGRP
                     GPVEIDLPKDVSTLEVTEINDPSLNLPHYHESEKATDEQLQELLTELSVSKKPVIIAG
                     GGINYSGSVDIFRAFVEKYQIPVVSTLLGLGTLPISHELQLGMAGMHGSYAANMALVE
                     ADYIINLGSRFDDRVVSNPAKFAKNAVVAHIDIDAAELGKIVKTDIPILSDLKAALSR
                     LLQLNKVRTDFNDWIKTVIENKEKAPFTYEPQNHDIRPQETIKLIGEYTQGDAIIVTD
                     VGQHQMWVAQYYPYKNARQLITSGGMGTMGFGIPAAIGAKLAQPNKNVIVFVGDGGFQ
                     MTNQELALLNGYGIAIKVVLINNHSLGMVRQWQESFYEERRSQSVFDVEPNFQLLAEA
                     YGIKHVKLDNPKTLADDLKIITEDEPMLIEVLISKSEHVLPMIPAGLHNDEMIGLHFT
                     DKNEEIDNA"
     CDS             9738..10214
                     /note="putative"
                     /gene="ilvN"
                     /codon_start=1
                     /translation="MRRMIIAKLHNVTGIMNRFTAVLNRRQVNILSITAGVTESQDLT
                     HTTFVIEVDHLDEVEQIIKQLNRLIDVIEVADITDFPHVEREVVLIKVSAPPTIRAEI
                     FTMIEPFRVNVVDVNLENVTIQLTGDSAKIEALIEVVSPYGILNMARTGSAGFERG"
     CDS             10260..11294
                     /note="putative"
                     /gene="ilvC"
                     /codon_start=1
                     /translation="MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNV
                     IIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGS
                     ALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGH
                     AREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAG
                     YAGELAYFEVLHEMKLIVDLMYEGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMK
                     LVLADIQSGKFAQDFVDDFKAGRPKLIAYREAAKNLEIEKIGAEHVKQCHSHNLVMTM
                     PLKSISNFSY"
     CDS             11337..12662
                     /note="putative"
                     /gene="ilvA"
                     /codon_start=1
                     /translation="MISAKEVEDAYDLLKAVVTKTPLQLDPYLSNKYQANIYLKEVVT
                     KTPLQLDPYLSNKYQANIYLKEENLQKVRSFKLRGAYYSISKLSDEQRSKGVVCASAG
                     NHAQGVAFAANQLNISATIFMPVTTPNQKISQVKFFGESHVTIRLIGDTFDESARAAK
                     AFSQDNDKPFIDPFDDENVIAGQGTVALEIFAQAKKQGISLDKIFVQIGGGGLIAGIT
                     AYSKERYPQTEIIGVEAKGATSMKAAYSAGQPVTLEHIDKFADGIAVATVGQKTYQLI
                     NDKVKQLLAVDEGLISQTILELYSKLGIVAEPAGATSVAALELIKDEIKGKNIVCIIS
                     GGNNDISRMQEIEERALVYEGLKHYFVINFPQRPGSLRTFVSDILGPNDDITRFEYIK
                     RADKGKGPCLVGILLSDASDYDSLINRIERFDNRYVNLRGNDSLYELLV"
BASE COUNT     4254 a   2046 c   2621 g   3799 t
ORIGIN      
        1 taaaactcga taatcttgag tcataatttc tccttaatct tattagtaca ttagaatcca
       61 ttataattta atcattttat gtctacctaa agcaacaaaa ttgcttgtat attttctaac
      121 aagcttaatt atgtggattt aattgaatat taaagggaga agttgtaatc tatttgttgt
      181 taaattcttg ttaatacaaa taaatttatt aaatattatt attttattga caatttaaaa
      241 tattaagagt attataatgt aaattaacaa aaaaaagagg aacttgaaat gacatacaca
      301 caattttcat tgttgttgat caaggtggac ctacattagc ttttttggct aaaatatgtg
      361 ggtcctgttt ggcgatagtc atttcgagga ccgagagacg tcctcacggg cgtctttttt
      421 gtttcttaat aaaaaataga ggtaatatta tgcgaaaaat tgaattcttt gacacaagtt
      481 tgagagatgg cgaacagaca ccgggcgtta gtttctccat ttcagaaaaa gtaacgattg
      541 ctaaacaact ggaaaaatgg aggatttctg tcatagaggc tggtttttct gcggcaagtc
      601 cagatagttt tgaagcagta aagcaaattg ctgattcttt gaatgatacg gctgtcactg
      661 cattagctcg ctgtgttatt tcagatatcg ataaagcggt tgaagcggta aagggggcta
      721 aatatccgca aattcatgtt ttcattgcaa cttcacctat tcacatgaaa tataaactta
      781 aaatcagtcc cgaagaagtt ttgaaaaata ttgataagtg tgtgagatac gcacgtgaac
      841 gggtcgaggt tgttgagttt tctccagagg atgcaacaag aacggagttg aattttcttt
      901 tagaggctgt tcaaacggct gtcgatgctg gagcaactta tattaatatt cctgacactg
      961 tcggttatac gacaccagaa gaatatggaa aaatttttaa atttttgatt gataatacta
     1021 agtctgaccg agaaattatt tttagtccac attgtcatga tgatttagga atggctgtag
     1081 ctaattcatt agctgcaatt aaagctgggg ctgggagagt tgaaggaact gtcaatggta
     1141 ttggagagcg agctgggaat gctgctcttg aagaaattgc tgtggcacta catattcgta
     1201 aagattttta tcaggcacaa agtcctttaa aactttcaga aactgctgca acggcagaac
     1261 taatttcaca attttcagga attgctattc caaaaaataa agcaattgtt ggtgctaatg
     1321 cttttgcaca cgaatcagga attcatcaag atggtgtcct taaaaatgct gaaacttatg
     1381 aaattattac accagaactt gtcggaataa agcataattc gttgccttta ggtaaacttt
     1441 ctggtcgtca tgcttttagt gaaaaattga cggaacttaa tattgcttat gacgatgaaa
     1501 gtcttgcaat tttatttgaa aaatttaaaa aattagctga caagaaaaaa gaaattactg
     1561 acgcagatat tcatgccttg tttacaggag aaacggtaaa aaatctagct ggatttatac
     1621 ttgataatgt tcaaattgat gggcacaagg cattggtgca actaaaaaat caagaagagg
     1681 aaatttatgt tagccaagga gaggggtcag gttcagtgga tgcaattttt aaagctattg
     1741 ataaagtctt taatcatcaa ctaaaattaa tttcctattc agttgatgct gtaactgatg
     1801 gaattgatgc acaagcaacg actttggttt ctgttgaaaa tctatctaca ggcactatat
     1861 ttaatgctaa aggtgttgat tatgatgtat tgaaaggaag cgccattgct tacatgaacg
     1921 ctaatgtttt agttcaaaaa gaaaatttac aaggaaaggt tgaacaaatt tcagctcatg
     1981 atggaattta aggtgaaaaa tattgtctaa aaaaattgtg acacttgcgg gagatggaat
     2041 tgggccagaa attatgtcag ctggtttaag tgttttaaaa gctgtcagta aaaaaattga
     2101 ttttgagtat gaattagaag ctaaagattt tggaggaatt gcaattgata agcatggtca
     2161 tcctttacca gaagaaactt tgcaagcagt taaaaatgct gacgcaatct tgctcgctgc
     2221 aattggtcat cctaaataca acaatgcaaa agttagacca gaacaagggc tacttgcttt
     2281 acgaaaagaa ttaggactgt atgctaatgt tcgtccatta aaaatttatc cggctctaaa
     2341 aaaactttct cccatacgaa atgttgaaaa tgttgatttc ctagtgattc gcgaacttac
     2401 agggggaatc tatttcggtc agcatgaatt ggcagatgat aaagcacgag atgtcaatga
     2461 ttattctgct gatgaaataa ggagaattct tcattttgct ttcaaaagtg ctcaaagtcg
     2521 gcccagaaaa ttactgactt cggttgataa acaaaatgtt cttgcaactt ctaaattatg
     2581 gcgaaaaatg gctgatgaaa ttgctgacga atatcctgat gtacgattag agcaccaatt
     2641 ggtcgattct tgtgcgatgt tactgattac taatccgcaa caatttgatg tgatagtcac
     2701 tgaaaatcta tttggtgata ttctctctga tgaagcaagt agtttggccg gtagcttagg
     2761 agtgatgcct tcgagttcgc atggatttaa cggtttagca ctctatgagc caattcatgg
     2821 ttcggcacca gatattgcag gaaaaggaat tgcgaaccct gtttcgatga ttctatcaat
     2881 tgccatgatg ctaagagaat cttttgggca agaagatggg gctgcgatga ttgaaaaagc
     2941 cgtaacccaa acttttactg acggaatttt gactaaagat ttaggtggga ctgcaacaac
     3001 taaagaaatg acagaagcaa tcctgaaaaa ttgtcagtaa aatgcgattg aatagtgagc
     3061 attttagttg tagataaaag aaccgtcagc atagctgaca attctgtcag taaatgcgat
     3121 tgaatagtga gcattttagt tgtagataaa agaaccgtca gcatagctga caattctgtc
     3181 agtaattgcg attgaatagt gagcatttta gttgtagata aaagaaccgt cagcatagct
     3241 gacaattctg tcagtaattg cgattgaata gtgagcattt tagttgtaga taaaagaact
     3301 atcagcgtaa ctgacaattc tgtcagtaaa tattactgac aaaaagtaca aaattactga
     3361 cagaatttgt cagaataaat ttttaaaaaa ggaaataaaa aaatgtcagg taaaacaata
     3421 tttgataaac tttgggatca gcatgtgatt gctggaaatg agggagaacc tcaactgctt
     3481 tatattgacc ttcatgttat tcatgaggtt acgagtccgc aagcatttca gggcttacgt
     3541 gaagcaggac gtcgtgttcg gagaaaagat ttgacatacg gaactcttga ccacaatgtt
     3601 ccaacacaaa atatttttaa tattcaagat ttgatttcta aaaaacaaat tgatactttt
     3661 actaaaaatg tcaaagaatt tgatgttcca gcggagactc atggtggaaa aggacaagga
     3721 attgttcaca tggtagcacc tgaatctggc agaactcaac cgggaaaaac aattgtttgt
     3781 ggcgatagtc ataccgcaac aaatggagca tttggtgcaa ttgcttttgg aattggtaca
     3841 agtgaagttg aacatgttct tgcaactcaa accatttggc aagttaaacc caagcgtatg
     3901 aaaattgaat ttcaaggtca tccacaaaaa ggaatttata gcaaagactt tatcctcgca
     3961 ttaattgcta aatatggtgt ggatgcaggt gtaggttatg cggttgaata tagtggggat
     4021 gctatcagtg atttaagcat ggaagaacgg atgacaatct gtaacatgtc aattgaattt
     4081 ggggcaaaaa ttggcctgat gaatcctgat gaaaaaactt atgactatgt caaagggcgt
     4141 gaacatgcac ctaaaaactt tgatgaagct gtcagtaaat gggaaaaact tgtcagtgat
     4201 tctgatgcac aatacgataa gattttaagt cttgatgtca gccagttgaa accaatggtg
     4261 acatggggaa caaatcccgg aatgggccta gaatttggcg aaaagtttcc ggaaattaac
     4321 aatgatttga attatgaacg tgcttatcag tacatggatt taaagccagg ccaaaccgct
     4381 tctgacatag atttaggcta tattttcatt ggttcttgta cgaatgctag acttggtgat
     4441 ttagaagaag ctgcaaaaat tattggagac agacatattg ctgatggact gacaggaatt
     4501 gtcgtccctg gaagcagacc tgtgaaagaa gcggctgaag cacaagggct tgataaaatt
     4561 tttaaagaag ctggttttga atggcgggaa ccgggttgct cagcctgtct tggaatgaat
     4621 cctgaccaaa ttccagaata cgttcattgt gcttcaacct ctaatcgaaa ttttgaaggt
     4681 cgtcaaggac ataatgcaag aacgcacctg tgctctccag ctatggctgc tgccgccgca
     4741 atcgctggta aatttgtaga tgttagaatg ctcgtaacag attagtctgt agaaagaaaa
     4801 aaagatggaa aaattcacga tttacaaagg gacaagtgtt ccagtcatga acgataatat
     4861 tgacacagac caaattattc ctaaacaatt tttgaaagca atcgataaaa agggctttgg
     4921 gaaaaattta ttttatgaat ggcgttatct taaagattac gatgagaatc ctgattttat
     4981 tttgaatgct ccaaaataca aaaaagcttc tctgttaatt tcaggagata attttggttc
     5041 gggttcttca agagaacatg cggcatgggc cttatcagat tacggctttc gggcaattat
     5101 tgctggctct tactcagata ttttttataa taatgcttta aaaaatggct tgttaccaat
     5161 taaacaacca agagaagttc taaatcaact gacaaaactg tcaagtcaag aagaaattac
     5221 aattgattta ccccatcagc taatcatcac aagccttggt gactttcatt ttgagattga
     5281 ccccatttgg aaagacaaat taattaatgg cttagatgat attggaataa ctttgcaata
     5341 tgaagaagca atctcagctt acgaacaaaa aaatcaataa gagcgagcct aaaatgacaa
     5401 ttattaattt aaagaatgta aatcttactc gaaataaaaa agaaattctt aaagatatta
     5461 cttggaaagt aaatcccggc gaaaattggg ttattctggg cctcaacggc tctggaaaat
     5521 caagtctttt gaaattgatt ttagcagaag aatggaaaac ttctggtgaa atcactgttt
     5581 taaatactca atttagaaat ggagaaattc ctaagttgag aaaaagaatc agcgtagttg
     5641 gctcatttat tgctgaaaga tttcaaccaa atattaaggc tgaaaacctt gtttatactg
     5701 ggaaatttaa ttcgagcatg ctctataaac cctacacaga tcaggaactt gatgaggccc
     5761 gtcagctttt aagacaaatg ggcgcaaaat cacttattgg ccgaaattat gccagccttt
     5821 ctcaagggga aaagcaagtt cttcttattg ctaggagctt aattttaaag cctgagcttt
     5881 taattttgga cgaagcaacg aacggtttag atttatttgc taaagaaaaa ttattaaagc
     5941 aactgcagca gattaatcaa ttaaaaaccg caccaacact aatttatatt tctcatcatc
     6001 ccgatgaaat cactgatatt tttactcacc ttttactttt aagagaagga aaagtgattc
     6061 aatcagggaa aaaagaaaac ttattaaatg aaaagatact tactgatttt tatcaagaaa
     6121 aagtagaagt tcaccgtttt gagcagaaat attttgtaat tcctgctaac tgagaaagga
     6181 aagcaaaagt attttatata ctatatagaa tattctgaca gattattgta ttttcatttt
     6241 tttagtgata aaatagctct atgtaaattt acggggaggt caaaaagata acatatggaa
     6301 ttcaaatata acggaaaagt tgaatcagtg gaactcaata aatattctaa gacattgact
     6361 ccaagatcaa cacaaccagc gactcaagcg atgtactacg gcattggttt taaagatgag
     6421 gatttcaaaa aagctcaggt cggaatcgtc agcatggatt gggacggaaa tccatgtaat
     6481 atgcacttgg gaacacttgg gagtaaaatc aaaagttctg tcaaccaaac tgacggattg
     6541 attggacttc aatttcatac tattggagtt tctgatggaa ttgctaacgg aaagcttggc
     6601 atgagatatt ctttggtcag tcgtgaagtt attgctgaca gcatcgaaac caacgctggc
     6661 gcagaatatt atgatgccat cgttgccatt cccggttgtg ataaaaatat gcccgggtca
     6721 attatcggaa tggctcgctt aaatcgtccg tcaattatgg tctatggtgg aacgattgaa
     6781 catggcgaat ataaaggtga aaaattaaat attgtttcgg cctttgaagc tctggggcaa
     6841 aaaatcactg gaaatatttc tgatgaagat tatcatggcg ttatttgcaa tgccattcca
     6901 ggacaaggtg cttgcggagg aatgtacact gccaataccc tggctgctgc tattgaaact
     6961 ttgggaatga gtttacctta ttcctcttcc aatccagcag tcagtcaaga aaaacaagaa
     7021 gagtgtgatg acattggttt agccatcaaa aatttattag aaaaagatat taaaccaagt
     7081 gatatcatga ccaaagaagc ttttgaaaat gccataacaa ttgtcatggt ccttggaggc
     7141 tcaaccaatg ctgtgcttca tatcattgca atggcaaatg ccattggtgt agaaattacg
     7201 caagatgatt tccaacgtat ttcagatatt atccctgttc ttggcgattt caaaccgagc
     7261 ggaaaatata tgatggaaga tctgcacaaa attggtggcc ttcctgctgt tttgaaatac
     7321 ctacttaaag aaggaaaact tcacggtgat tgtttgaccg tcacaggtaa aactttggct
     7381 gaaaatgttg aaacagcatt agatttggac tttgacagtc aagatattat gcgaccacta
     7441 aaaaatccaa ttaaagctac tggacattta caaattttgt acggtaatct tgcccaaggg
     7501 ggttctgttg caaaaatttc tggtaaagaa ggcgaatttt tcaaaggaac agctcgtgtt
     7561 tttgacggag aacaacactt tatcgatggc attgagtctg gccgattgca tgccggtgat
     7621 gttgcggtca ttagaaatat tggcccagtc ggaggtccgg gaatgccaga gatgttaaaa
     7681 ccaacctcag cattaattgg agcaggactt ggaaaatctt gtgccctaat tactgacgga
     7741 agattttctg gtggcacaca cggctttgtt gtgggtcata tcgtccctga agcagttgaa
     7801 ggtgggttga ttggtttagt tgaagatgat gatattatcg aaattgatgc ggtgaataat
     7861 agtattagtt taaaagtttc taatgaagaa attgctaaac gacgtgccaa ttatcaaaaa
     7921 ccaaccccta aagcaacgcg tggtgttctt gcaaaatttg ccaaacttac gcgccccgct
     7981 agtgaaggtt gcgttacaga tttatagaaa ggtttgaatg aaaaaaataa agttagaaaa
     8041 acctacttcc ggttcccaac ttgttctcca aaccttaaaa gaacttggag tagaaattat
     8101 ttttggttat cctggtgggg ccatgctccc cttgtatgat gcgattcata attttgaagg
     8161 aattcaacat attttagccc gtcatgagca aggagcaacg catgaagccg aaggttacgc
     8221 taaatcgtct ggtaaagttg gtgtcgtcgt tgttacgtca ggaccaggag cgactaatgc
     8281 agtaaccgga attgctgacg cttatcttga ttcagtccca ttgttagttt tcacaggtca
     8341 agttggccgt cagtcaattg gtaaagatgc ttttcaagaa gcagatactg ttggaattac
     8401 agccccaatt acaaaatata attatcaaat tagggaaacc gcagatattc caagaattgt
     8461 tacagaagcc tattatttgg caaggacagg acgtcctgga ccagtagaaa ttgatttacc
     8521 aaaagatgtt tccacccttg aagtcactga aattaatgac ccaagcttga atcttcctca
     8581 ttatcacgaa agtgaaaaag cgactgatga acaattgcaa gaattactga cagaactttc
     8641 tgtcagtaaa aaaccagtca ttattgctgg cggaggaatt aattattctg gctcagttga
     8701 tattttcaga gcatttgtcg aaaaatatca aattccagtt gtttctacat tgcttggctt
     8761 aggaacatta ccaatcagcc acgaattgca actaggaatg gcaggaatgc acggttcata
     8821 cgctgcaaat atggctttag ttgaagctga ctatattatt aatttgggat cacgttttga
     8881 cgatagagtt gtatccaatc ctgcaaaatt tgctaaaaat gctgtcgttg ctcatattga
     8941 tattgacgct gctgaacttg gcaaaattgt aaaaaccgat attccaatcc tttctgattt
     9001 gaaagcggct ttaagcagac ttttgcaatt aaataaggtc aggactgact ttaatgattg
     9061 gattaaaact gtcattgaaa ataaagagaa agcaccattt acttatgagc cccaaaacca
     9121 tgatatccgt ccacaggaaa caattaaatt aattggagaa tacactcaag gagatgcaat
     9181 cattgtaact gacgttgggc aacatcaaat gtgggtggcg caatattatc cttataaaaa
     9241 tgcaaggcaa cttattactt ctgggggaat gggaacgatg ggctttggca ttcctgcagc
     9301 aatcggtgca aagctggcac agccaaataa aaatgtcatt gtttttgttg gcgatggtgg
     9361 ctttcaaatg actaatcaag aattagcatt acttaatggc tacggtattg caatcaaagt
     9421 tgtgctgatt aataatcatt cattgggaat ggtacgtcaa tggcaagaat cattctatga
     9481 agagcgacgt tcacaatcgg tttttgatgt tgaacccaat tttcaattgt tagccgaagc
     9541 ttatggcatc aaacatgtta agttagataa tccaaaaact ttggctgatg atttaaaaat
     9601 tattacagaa gatgagccaa tgcttattga agttctaatt tcaaaatctg agcatgtttt
     9661 accaatgata ccagctggat tacacaatga cgaaatgatt ggacttcatt ttactgataa
     9721 gaatgaggag atagataatg cgtagaatga ttatcgcaaa acttcataac gtgacaggaa
     9781 ttatgaatcg atttaccgcc gttctcaatc gaaggcaagt gaacattctc tcaattaccg
     9841 ctggagttac agaaagtcaa gacttaactc ataccacttt tgttattgaa gttgatcatc
     9901 ttgatgaagt agaacaaatc attaaacaat taaatcgctt aatagatgta attgaagtag
     9961 ctgatattac tgattttcct catgtagaac gtgaagtcgt cttgattaaa gtatcagctc
    10021 caccgaccat tagggcagaa atttttacaa tgattgaacc ttttagagta aatgtagttg
    10081 atgtcaatct ggaaaatgtc accattcaat taacgggtga ttcagcaaaa atcgaagcac
    10141 ttattgaggt tgttagtcct tatggcattc taaatatggc tcggacaggt agtgcaggtt
    10201 ttgagcgtgg ctaaatttaa ataagttaac aaataaatag aaaaatagag gaaacaaaaa
    10261 tggcagttac aatgtattat gaagatgatg tagaagtatc agcacttgct ggaaagcaaa
    10321 ttgcagtaat cggttatggt tcacaaggac atgctcacgc acagaatttg cgtgattctg
    10381 gtcacaacgt tatcattggt gtgcgccacg gaaaatcttt tgataaagca aaagaagatg
    10441 gctttgaaac atttgaagta ggagaagcag tagctaaagc tgatgttatt atggttttgg
    10501 caccagatga acttcaacaa tccatttatg aagaggacat caaaccaaac ttgaaagcag
    10561 gttcagcact tggttttgct cacggattta atatccattt tggctatatt aaagtaccag
    10621 aagacgttga cgtctttatg gttgcgccta aggctccagg tcaccttgtc cgtcggactt
    10681 atactgaagg ttttggtaca ccagctttgt ttgtttcaca ccaaaatgca agtggtcatg
    10741 cgcgtgaaat cgcaatggat tgggccaaag gaattggttg tgctcgagtg ggaattattg
    10801 aaacaacttt taaagaagaa acagaagaag atttgtttgg agaacaagct gttctatgtg
    10861 gaggtttgac agcacttgtt gaagccggtt ttgaaacact gacagaagct ggatacgctg
    10921 gcgaattggc ttactttgaa gttttgcacg aaatgaaatt gattgttgac ctcatgtatg
    10981 aaggtggttt tactaaaatg cgtcaatcca tctcaaatac tgctgagttt ggcgattatg
    11041 tgactggtcc acggattatt actgacgaag ttaaaaagaa tatgaagctt gttttggctg
    11101 atattcaatc tggaaaattt gctcaagatt tcgttgatga cttcaaagcg gggcgtccaa
    11161 aattaatagc ctatcgcgaa gctgcaaaaa atcttgaaat tgaaaaaatt ggggcagagc
    11221 acgtcaagca atgccattca cacaatctgg tgatgacgat gcctttaaaa tctatcagta
    11281 atttctctta ttgattgaac aaaaacataa aagcatttta tggaggaatg acataaatga
    11341 taagtgccaa agaggttgaa gatgcctatg atttgttaaa agcagttgtc actaaaacac
    11401 ctttacaatt agacccttac ctttccaata aatatcaagc aaatatttac ttaaaagaag
    11461 ttgtcactaa aacaccttta caattagacc cttacctttc caataaatat caagcaaata
    11521 tttacttaaa agaagaaaac ttacagaaag ttcgttcttt taaattacga ggagcttatt
    11581 attctatcag taaattatct gatgagcaac gctctaaagg agtggtttgt gcctcagcag
    11641 gaaatcatgc acaaggggtt gcttttgctg caaatcaatt aaatatttct gcgacaattt
    11701 ttatgcccgt taccacacct aaccaaaaaa tttcacaagt taaatttttt ggcgaaagtc
    11761 acgtaacaat tcgtttaatt ggtgatactt ttgatgaatc agccagagca gcaaaagctt
    11821 tttctcaaga taatgacaaa ccatttatag acccttttga tgatgaaaat gtaattgctg
    11881 gtcaagggac agtggcttta gaaatttttg cgcaagctaa aaaacaagga ataagtttag
    11941 ataagatttt tgtacagatt ggtggaggtg gtttaattgc aggaattact gcctacagta
    12001 aggagcgcta tccccaaact gaaattatcg gagttgaagc aaaaggggca acaagtatga
    12061 aagctgccta ctctgctggt cagcccgtca ccttggaaca cattgataaa tttgctgacg
    12121 gaattgcggt tgcgactgtc ggtcagaaaa cttaccaact tattaatgac aaagtgaaac
    12181 aattgcttgc ggttgatgaa ggtttaattt ctcaaaccat actcgaattg tattcaaaat
    12241 taggaattgt cgccgagcca gcaggtgcaa catctgttgc cgcacttgaa cttattaaag
    12301 atgaaatcaa gggtaaaaat atcgtctgta tcatcagcgg cggaaataat gatattagtc
    12361 gaatgcaaga aattgaagaa agagctttgg tttatgaagg tctaaaacat tattttgtca
    12421 ttaactttcc tcaaagacca ggatccttac gaacttttgt cagtgatatt ttagggccaa
    12481 atgatgatat cacccgattt gagtacatca aaagggctga taaaggtaaa ggaccttgtc
    12541 ttgttgggat tttactttca gatgctagtg attatgattc attgattaat cggattgaaa
    12601 gatttgataa tcgttatgtt aacttacgtg gaaatgatag tttatacgaa cttttggtct
    12661 aactaaccaa ttggtttgag ccattttcta gtttcaattc tctttaaatc actagaaatt
//