From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens mRNA for ATP-citrate lyase
Date: 29 Dec 92 00:45:19 GMT
Distribution: bionet
Checksum: 57363 9

LOCUS       HUMATPCITL   4297 bp ss-mRNA            PRI       03-DEC-1992
DEFINITION  H.sapiens mRNA for ATP-citrate lyase
ACCESSION   X64330
KEYWORDS    ATP citrate-lyase; cholesterol biosynthesis.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Elshoubagy,N., Near,J.C., Kmetz,P., Wells,T.N., Groot,P.C.,
            Sanxty,B., Franklin,M. and Gloger,I.S.
  TITLE     Cloning and expression of a human ATP-citrate lyase cDNA
  JOURNAL   Eur. J. Biochem. (1992) In press
  STANDARD  full automatic
COMMENT     *source: stage=adult male; *source: tissue=liver; *source:
            clone_library=lambda zap cDNA library;
               Related sequence: J05210
               From EMBL    entry HSATPCITL;  dated 10-FEB-1992.
FEATURES             Location/Qualifiers
     5'UTR           1..84
     3'UTR           3403..4297
     CDS             85..3402
                     /EC_number="4.1.3.8"
                     /gene="ATP-citrate lyase"
                     /product="ATP-citrate (pro-S-)-lyase"
                     /codon_start=1
                     /translation="MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLL
                     QDHPWLLSQNLVVKPDQLIKRRGKLGLVGVDLTLDGVKSWLKPRLGQEATVGKATGFL
                     KNFLIEPFAPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKL
                     NPEDIKKHLLVHAPDDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLA
                     AKVDATADYICKVKWGDIEFPPPFGRVAYPEEAYIADLDAKSGASLKLTLLNPKGRIW
                     TMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPD
                     GKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMG
                     EVGKTTGIPIHVFGTETHMTAIVGMAWAPAIPNQPPTAAHTANFLLNAQRETSTPAPS
                     RTASFYESMVDEVRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGM
                     QTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRK
                     HPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTI
                     IGPATVGGIKPGCFKIGNTGGMLDNILASKLYPQAAVAYVSRSGGMSNELNNIISRTT
                     DGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKISRGIKEGRL
                     TKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELG
                     EIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQEL
                     IYAGMPITEVFKEEMGIGGALGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNT
                     IICARTAVELVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGK
                     LIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVD
                     GLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLY
                     RHPWDDISYVLPEHMSM"
BASE COUNT     1048 a   1105 c   1132 g   1012 t
ORIGIN      
        1 cccggatttt gcggggttcg tcgggcctgt ggaagaagcc ccgccacgga cttcggcaga
       61 ggtagagcag gtctctctgc agccatgtcg gccaaggcaa tttcagagca gacgggcaaa
      121 gaactccttt acaagttcat ctgtaccacc tcagccatcc agaatcggtt caagtatgct
      181 cgggtcactc ctgacacaga ctgggcccgc ttgctgcagg accacccctg gctgctcagc
      241 cagaacttgg tagtcaagcc agaccagctg atcaaacgtc gtggaaaact tggtctcgtt
      301 ggggtcgacc tcactctgga tggggtcaag tcctggctga agccacggct gggacaggaa
      361 gccacagttg gcaaggccac aggcttcctc aagaactttc tgatcgagcc cttcgccccc
      421 cacagtcagg ctgaggagtt ctatgtctgc atctatgcca cccgagaagg ggactacgtc
      481 ctgttccacc acgagggggg tgtggacgtg ggtgatgtgg acgccaaggc ccagaagctg
      541 cttgttggcg tggatgagaa actgaatcct gaggacatca aaaaacacct gttggtccac
      601 gcccctgacg acaagaaaga aattctggcc agttttatct ccggcctctt caatttctac
      661 gaggacttgt acttcaccta cctcgagatc aatccccttg tagtgaccaa agatggagtc
      721 tatgtccttg acttggcggc caaggtggac gccactgccg actacatctg caaagtgaag
      781 tggggtgaca tcgagttccc tccccccttc gggcgggtgg catatccaga ggaagcctac
      841 attgcagacc tcgatgccaa aagtggggca agcctgaagc tgaccttgct gaaccccaaa
      901 gggaggatct ggaccatggt ggccgggggt ggcgcctctg tcgtgtacag cgataccatc
      961 tgtgatctag ggggtgtcaa cgagctggca aactatgggg agtactcagg cgcccccagc
     1021 gagcagcaga cctatgacta tgccaagact atcctctccc tcatgacccg agagaagcac
     1081 ccagatggca agatcctcat cattggaggc agcatcgcaa acttcaccaa cgtggctgcc
     1141 acgttcaagg gcatcgtgag agcaattcga gattaccagg gccccctgaa ggagcacgaa
     1201 gtcacaatct ttgtccgaag aggtggcccc aactatcagg agggcttacg ggtgatggga
     1261 gaagtcggga agaccactgg gatccccatc catgtctttg gcacagagac tcacatgacg
     1321 gccattgtgg gcatggcctg ggcaccggcc atccccaacc agccacccac agcggcccac
     1381 actgcaaact ttctcctcaa cgcccagcgg gagacatcga ctccagcccc cagcaggaca
     1441 gcatcttttt atgagtccat ggtcgatgag gtcagggccg atgaggtggc gcctgcaaag
     1501 aaggccaagc ctgccatgcc acaagattca gtcccaagtc caagatccct gcaaggaaag
     1561 agcaccaccc tcttcagccg ccacaccaag gccattgtgt ggggcatgca gacccgggcc
     1621 gtgcaaggca tgctggactt tgactatgtc tgctcccgag acgagccctc agtggctgcc
     1681 atggtctatc ctttcactgg ggaccacaag cagaagtttt actgggggca caaagagatc
     1741 ctgatccctg tcttcaagaa catggctgat gccatgagga agcacccgga ggtagatgtg
     1801 ctcatcaact ttgcctctct ccgctctgcc tatgacagca ccatggagac catgaactat
     1861 gcccagatcc ggaccatcgc catcatagct gaaggcatcc ctgaggccct cacgagaaag
     1921 ctgatcaaga aggcggacca gaagggagtg accatcatcg gacctgccac tgttggaggc
     1981 atcaagcctg ggtgctttaa gattggcaac acaggtggga tgctggacaa catcctggcc
     2041 tccaaactgt acccccaggc agctgtggcc tatgtctcac gttccggagg catgtccaac
     2101 gagctcaaca atatcatctc tcggaccacg gatggcgtct atgagggcgt ggccattggt
     2161 ggggacaggt acccgggctc cacattcatg gatcatgtgt tacgctatca ggacactcca
     2221 ggagtcaaaa tgattgtggt tcttggagag attgggggca ctgaggaata taagatttcc
     2281 cggggcatca aggagggccg cctcactaag cccatcgtct gctggtgcat cgggacgtgt
     2341 gccaccatgt tctcctctga ggtccagttt ggccatgctg gagcttgtgc caaccaggct
     2401 tctgaaactg cagtagccaa gaaccaggct ttgaaggaag caggagtgtt tgtgccccgg
     2461 agctttgatg agcttggaga gatcatccag tctgtatacg aagatctcgt ggccaatgga
     2521 gtcattgtac ctgcccagga ggtgccgccc ccaaccgtgc ccatggacta ctcctgggcc
     2581 agggagcttg gtttgatccg caaacctgcc tcgttcatga ccagcatctg cgatgagcga
     2641 ggacaggagc tcatctacgc gggcatgccc atcactgagg tcttcaagga agagatgggc
     2701 attggcgggg ccctcggcct cctctggttc cagaaaaggt tgcctaagta ctcttgccag
     2761 ttcattgaga tgtgtctgat ggtgacagct gatcacgggc cagccgtctc tggagcccac
     2821 aacaccatca tttgtgcgcg caccgcggtg gagctggtct ccagcctcac ctcggggctg
     2881 ctcaccatcg gggatcggtt tgggggtgcc ttggatgcag cagccaagat gttcagtaaa
     2941 gcctttgaca gtggcattat ccccatggag tttgtgaaca agatgaagaa ggaagggaag
     3001 ctgatcatgg gcattggtca ccgagtgaag tcgataaaca acccagacat gcgagtgcag
     3061 atcctcaaag attacgtcag gcagcacttc cctgccactc ctctgctcga ttatgcactg
     3121 gaagtagaga agattaccac ctcgaagaag ccaaatctta tcctgaatgt agatggtctc
     3181 atcggagtcg catttgtaga catgcttaga aactgtgggt cctttactcg ggaggaagct
     3241 gatgaatata ttgacattgg agccctcaat ggcatctttg tgctgggaag gagtatgggg
     3301 ttcattggac actatcttga tcagaagagg ctgaagcagg ggctgtatcg tcatccgtgg
     3361 gatgatattt catatgttct tccggaacac atgagcatgt aacagagcca ggaaccctac
     3421 tgcagtaaac tgaagacaag aactcttccc ccaagaaaaa gtgtcagaca gctggcagtg
     3481 gagcctgctt tatttagcag gggcctggaa tgtaaacagc cactggggta caggcaccga
     3541 agaccaacat ccacaggcta acaccccttc agtccacaca aagaagcttc atattttttt
     3601 tataagcata gaaataaaaa ccaagccaat atttgtgact ttgctctgct acctgctgta
     3661 tttattatat ggaagcatct aagtactgtc aggatggggt cttcctcatt gtagggcgtt
     3721 aggatgttgc tttctttttc cattagttaa acattttttt ctcctttgga ggaagggaat
     3781 gaaacattta tggcctcaag atactataca tttaaagcac cccaatgtct ctcttttttt
     3841 ttttttttac ttcccttgct tcttccttat ataacatgaa gaacattgta ttaatctgat
     3901 ttttaaagac tttttgtatg ttacgtgtta agggcttgtt tggtatccca ctgaaatgtt
     3961 ctgtgttgca gaccagagtc tgtttatgtc agggggaggg ggccattgca tccttagcca
     4021 ttgtcacaaa atatgtggag tagtaactta atatgtaaag ttgtaacata catacattta
     4081 aaatggaaat gcagaaagct gtgaaatgtc ttgtgtctta tgttctctgt atttatgcag
     4141 ctgatttgtc tgtctgtaac tgaagtgtgg gtccaaggac tcctaactac tttgcatctg
     4201 taatccacaa agattctggg cagctgccac ctcagtctct tctctgtatt atcatagtct
     4261 ggtttaaata aactatatag taacaggaat tcctgca
//