From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human immunodeficiency virus type 1 proviral DNA encoding the vif,
Date: 22 Dec 92 22:42:55 GMT
Distribution: bionet
Checksum: 07492 12

LOCUS       HIV1PROV     4684 bp ds-DNA             VRL       23-NOV-1992
DEFINITION  Human immunodeficiency virus type 1 proviral DNA encoding the vif,
            vpr, vpu, env, tat, rev and nef genes, complete cds, and 3' LTR.
ACCESSION   M96155
KEYWORDS    LTR; env gene; envelope polyprotein; glycoprotein 120;
            glycoprotein 41; long terminal repeat; nef gene; rev gene;
            tat gene; vif gene; vpr gene; vpu gene.
SOURCE      Human immunodeficiency virus type 1 (library: subgenomic lambda
            pahge library of HMW) DNA.
  ORGANISM  Human immunodeficiency virus type 1
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Retroviridae; Lentivirinae.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Collman,R., Balliet,J.W., Gregory,S.A., Friedman,H., Kolson,D.L.,
            Nathanson,N. and Srinivasan,A.
  TITLE     An infectious molecular clone of an unusual macrophage-tropic and
            highly cytopathic strain of HIV-1
  JOURNAL   J. Virol. 66, 7517-7521 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     intron          1015..3338
                     /gene="tat"
     intron          1015..3338
                     /gene="rev"
     mat_peptide     1194..2717
                     /product="glycoprotein 120"
                     /gene="env"
                     /codon_start=1
     mat_peptide     2718..3752
                     /product="glycoprotein 41"
                     /gene="env"
                     /codon_start=1
     LTR             4049..4684
     repeat_region   4049..4502
                     /rpt_type=other
                     /note="U3 region"
     repeat_region   4503..4599
                     /rpt_type=other
                     /note="R region"
     repeat_region   4600..4684
                     /rpt_type=other
                     /note="U5 region"
     CDS             join(800..1014,3339..3429)
                     /gene="tat"
                     /note="tat"
                     /codon_start=1
                     /translation="MEPVNPSLEPWKHPGSQPKTACTNCYCKKCCFHCQACFITKGLG
                     ISYGRKKRRQRRRPPQDSQTHQVSLSKQPSSQPRGDPTGPKEQKKKVERETETDPVH"
     CDS             join(939..1014,3339..3613)
                     /gene="rev"
                     /note="rev"
                     /codon_start=1
                     /translation="MAGRSGDSDEDLLKTVRLIKFLYQSNPPPSLEGTRQARRNRRRR
                     WRERQRQIRSISERILGTFLGRFEEPVPLPLPPLEKLTLDCNEDCGTSGTQGVGSPQI
                     LVESPAILEPGTKE"
     CDS             11..589
                     /gene="vif"
                     /note="vif"
                     /codon_start=1
                     /translation="MENRWQVMIVWQVDRMRIRTWKSLVKHHMYISGKAKGWSYRHHY
                     ESTNPRISSEVHIPLGDAKLVVTTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPGL
                     ADRLIHLYYFDCFSDSAIRKSILGHIVSPSCEYQAGHNKVGSLQYLALAALTTPRRIK
                     PPFPSVTKLTEDRWNKPQKTKGHRGSHTMTGH"
     CDS             529..819
                     /gene="vpr"
                     /note="vpr"
                     /codon_start=1
                     /translation="MEQAPEDQGPQREPYNDWTLELLEELKNEAVRHFPRIWLHSLGQ
                     HIYETYGDTWTGVEALIRILQQLLFIHFRIGCRHSRIGIIQHRRTRNGASKS"
     CDS             1031..1273
                     /gene="vpu"
                     /note="vpu"
                     /codon_start=1
                     /translation="MLSLQILAIVALVVAAIIAIVVWSIVFIEYRKILRQRKIDRLID
                     RIREREEDSGNESEGDQEELAALERGHLAPWDVDDL"
     CDS             1194..3755
                     /gene="env"
                     /product="envelope polyprotein"
                     /codon_start=1
                     /translation="MRVKEIRKNWQHLRGGILLLGMLMICSAAKEKTWVTIYYGVPVW
                     REATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLGNVTENFNMWKNNMVDQ
                     MHEDIISLWDESLKPCVKLTPLCVTLNCTNLNITKNTTNPTSSSWGMMEKGEIKNCSF
                     YITTSIRNKVKKEYALFNRLDVVPIENTNNTKYRNHRCNTSVITQACPKVSFQPIPIH
                     YCVPAGFAMLKCNNKTFNGSGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEDIVIRS
                     ENFTDNAKTIIVQLNESVVINCTRPNNNTRRRLSIGPGRAFYARRNIIGDIRQAHCNI
                     SRAKWNNTLQQIVIKLREKFRNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTAQLFN
                     STWNVTGGTNGTEGNDIITLQCRIKQIINMWQKVGKAMYAPPITGQIRCSSNITGLLL
                     TRDGGNSTETETEIFRPGGGDMRDNWRSELYKYKVVRIEPIGVAPTRAKRRTVQREKR
                     AVGIGAVFLGFLGAAGSTMGARSVTLTVQARLLLSGIVQQQNNLLRAIEAQQHMLQLT
                     VWGIKQLQARVLALERYLRDQQLMGIWGCSGKLICTTSVPWNVSWSNKSVDDIWNNMT
                     WMEWEREIDNYTDYIYDLLEKSQTQQEKNEKELLELDKWASLWNWFDITNWLWYIRLF
                     IMIVGGLIGLRIVFAVLSIVNRVRQGYSPLSFQTLLPASRGPDRPEGTEEEGGERDRD
                     RSGPLVNGFLALFWVDLRNLCLFLYHLLRNLLLIVTRIVELLGRRGWEALKYWWNLLQ
                     YWSQELKNSAVSLLNATAIAVAEGTDRVIKIVQRACRAIRNIPTRIRQGLERALL"
     CDS             3757..4371
                     /gene="nef"
                     /note="nef"
                     /codon_start=1
                     /translation="MGGKWSKRRAEGWQTIRERMRRAEPAEPAADGVGAVSRDLARHG
                     AITSSNTNNADIAWLEAQEEGEVGFPVRPQVPLRPMTYKAAVDLSHFLKEKGGLEGLV
                     HSQKRQDILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPDEGENNRED
                     NSLLHPANQHGVEDSERQVLVWRFDSRLAFHHVARELHPEYFKN"
BASE COUNT     1579 a    849 c   1145 g   1111 t
ORIGIN      
        1 attagggatt atggaaaaca gatggcaggt gatgattgtg tggcaagtag acaggatgag
       61 gattagaaca tggaaaagtt tagtaaaaca ccatatgtat atttcaggga aagctaaggg
      121 atggtcttat agacatcact atgaaagcac taatccaaga ataagttcag aagtacacat
      181 cccactaggg gatgctaaat tggtagtaac aacatattgg ggtctgcata caggagaaag
      241 agactggcat ttgggtcagg gagtctccat agaatggagg aaaaagagat atagcacaca
      301 agtagaccct ggcctagcag accgactaat tcatctgtat tactttgatt gtttttcaga
      361 ctctgctata agaaagtcca tattaggaca tatagttagc cctagttgtg aatatcaagc
      421 aggacataac aaggtaggat ctctacagta cttggcacta gcagcattaa caacaccaag
      481 aaggataaag ccaccctttc ctagtgttac gaaactgaca gaggatagat ggaacaagcc
      541 ccagaagacc aagggccaca gagggagcca tacaatgact ggacactaga gcttttagag
      601 gagcttaaga atgaagctgt gagacatttc cctaggatat ggctccatag tttagggcaa
      661 catatctatg aaacttatgg ggatacttgg acaggagtgg aagccttaat aagaattctg
      721 caacaactgc tgtttattca tttcagaatt gggtgtcgac atagcagaat aggcattatt
      781 caacacagga gaacaagaaa tggagccagt aaatcctagc ctagagccct ggaagcatcc
      841 aggaagtcag cctaaaactg cttgtaccaa ttgctattgc aaaaaatgtt gctttcattg
      901 ccaagcttgt ttcataacaa aaggcttagg catctcctat ggcaggaaga agcggagaca
      961 gcgacgaaga cctcctcaag acagtcagac tcatcaagtt tctctatcaa agcagtaagt
     1021 agtacatgta atgctttctt tacaaatatt agcaatagta gcattagtag tagcagcaat
     1081 aatagcaata gttgtgtggt ctatagtatt catagaatat aggaaaatat taagacaaag
     1141 aaaaatagac agattaattg atagaataag agaaagagaa gaagacagtg gcaatgagag
     1201 tgaaggagat caggaagaat tggcagcact tgagaggggg catcttgctc cttgggatgt
     1261 tgatgatctg tagtgctgca aaagaaaaaa cgtgggtcac aatctattat ggggtacctg
     1321 tgtggagaga agcaaccacc actctatttt gtgcatcaga tgctaaagcc tatgatacag
     1381 aggtacataa tgtttgggcc acacatgcct gtgtacccac agaccccaac ccacaagaag
     1441 tagtattggg aaatgtgaca gaaaatttta acatgtggaa aaataacatg gtagatcaga
     1501 tgcatgagga tataatcagt ttatgggatg aaagcctaaa gccatgtgta aaattaaccc
     1561 cactctgtgt tactttaaat tgcactaatt tgaatatcac taagaatact actaatccca
     1621 ctagtagcag ctggggaatg atggagaaag gagaaataaa aaattgctct ttctatatca
     1681 ccacaagcat aagaaataag gtaaagaaag aatatgcact ttttaataga cttgatgtag
     1741 taccaataga aaatactaat aatactaagt ataggaacca ccgttgtaac acctcagtca
     1801 ttacacaggc ctgtccaaag gtatcctttc agccaattcc catacattat tgtgtcccgg
     1861 ctgggtttgc gatgctaaag tgtaacaata agacattcaa tggatcagga ccatgcacaa
     1921 atgtcagcac agtacaatgt acacatggaa ttaggccagt ggtgtcaact caactgctgt
     1981 taaatggcag tctagcagaa gaagacatag taattagatc tgaaaatttc acagacaatg
     2041 ctaaaaccat aatagtacag ctaaatgaat ctgtagtaat taattgtaca agacccaaca
     2101 acaatacaag aagaaggtta tctataggac cagggagagc attttatgca agaagaaaca
     2161 taataggaga tataagacaa gcacattgta acattagtag agcaaaatgg aataacactt
     2221 tacaacagat agttataaaa ttaagagaaa aatttaggaa taaaacaata gcctttaatc
     2281 aatcctcagg aggggaccca gaaattgtaa tgcacagttt taattgtgga ggggaatttt
     2341 tctactgtaa tacagcacaa ctgtttaata gtacttggaa tgttactgga gggacaaatg
     2401 gcactgaagg aaatgacata atcacactcc aatgcagaat aaaacaaatt ataaatatgt
     2461 ggcagaaagt aggaaaagca atgtatgccc ctcccatcac aggacaaatt agatgttcat
     2521 caaatattac agggctgcta ctaacaagag atggaggtaa tagtactgag actgagactg
     2581 agatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa ttatataaat
     2641 ataaagtagt aagaattgaa ccaataggag tagcacccac cagggcaaag agaagaacag
     2701 tgcaaagaga aaaaagagca gtgggaatag gagctgtgtt ccttgggttc ttgggagcag
     2761 caggaagcac tatgggcgca cggtcagtga cgctgacggt acaggccagg ctattattgt
     2821 ctggtatagt gcagcagcag aacaatctgc tgagggctat tgaggcgcaa cagcatatgt
     2881 tgcaactcac agtctggggc atcaagcagc tccaggcaag agtcctggct ctggaaagat
     2941 acctaaggga tcaacagctc atgggaattt ggggttgctc tggaaaactc atttgcacca
     3001 cttctgtgcc ttggaatgtt agttggagta ataaatctgt ggatgatatt tggaataaca
     3061 tgacctggat ggagtgggaa agagaaattg acaattacac agactatata tatgacttac
     3121 ttgaaaaatc gcaaacccaa caagaaaaga atgaaaaaga attattggaa ttggataaat
     3181 gggcaagttt gtggaattgg tttgacataa caaactggct gtggtatata agattattca
     3241 taatgatagt aggaggcttg ataggtttaa gaatagtttt tgctgtactt tctatagtaa
     3301 atagagttag gcagggatat tcaccattat cgtttcagac cctcctccca gcctcgaggg
     3361 gacccgacag gcccgaagga acagaagaag aaggtggaga gagagacaga gacagatccg
     3421 gtccattagt gaacggattc ttggcacttt tctgggtcga tttgaggaac ctgtgcctct
     3481 tcctctacca cctcttgaga aacttactct tgattgtaac gaggattgtg gaacttctgg
     3541 gacgcagggg gtgggaagcc ctcaaatatt ggtggaatct cctgcaatat tggagccagg
     3601 aactaaagaa tagtgctgtt agcttgctca acgccacagc catagcagta gctgagggga
     3661 cagatagggt tataaaaata gtacaaagag cttgtagagc tattcgcaac atacctacaa
     3721 gaatcagaca gggcttggaa agggctttgc tataagatgg gaggcaagtg gtcaaaacgt
     3781 agggcagagg gatggcagac tataagggaa agaatgagac gagctgaacc agctgaacca
     3841 gcagcagatg gggtgggagc agtatctcga gacctggcga gacatggagc tatcacaagt
     3901 agcaatacta acaatgctga tattgcctgg ctggaagcac aagaggaggg agaagtgggt
     3961 tttccagtca gacctcaggt acctttaaga ccaatgactt acaaggcagc tgtagatctt
     4021 agccactttt taaaagaaaa ggggggactg gaagggctag ttcactccca gaaaagacaa
     4081 gatatccttg atctgtgggt ctaccacaca caaggcttct tcccagattg gcagaactac
     4141 acaccagggc caggaatcag atatccactg acctttggat ggtgctacaa gctagtacca
     4201 gttgagccag atgaaggaga gaacaacaga gaggacaaca gcttgctaca ccctgctaac
     4261 cagcatggag tagaagactc ggagagacaa gtgttagtgt ggaggtttga cagccgccta
     4321 gcattccatc acgtggcccg agagctgcat ccggagtact tcaagaactg aactgctgac
     4381 actgagctat ctacaaggga ctttccgctg gggactttcc agggaggtgt ggcctgggcc
     4441 gaactgggga gtggcgagcc ctcagatgct gcatataagc agctgctttt tgcctgtact
     4501 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctagct agggaaccca
     4561 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg
     4621 tgtgactctg gtagctagag atccctcaga ccatcctagt tagtgtagaa aatctctagc
     4681 aggg
//