From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human voltage-gated potassium channel. (HK1) mRNA, complete cds.
Date: 29 Dec 92 21:38:16 GMT
Distribution: bionet
Checksum: 38438 6

LOCUS       HUMVENHK1    2445 bp ss-mRNA            PRI       15-DEC-1992
DEFINITION  Human voltage-gated potassium channel. (HK1) mRNA, complete cds.
ACCESSION   M60450
KEYWORDS    voltage-gated potassium channel.
SOURCE      Human ventricular heart muscle, cDNA to mRNA, clone HK1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Tamkun,M.M., Knoth,K.M., Walbridge,J.A., Kroemer,H., Roden,D.M. and
            Glover,D.M.
  TITLE     Molecular cloning and characterization of two voltage-gated K+
            channel cDNAs from human ventricle
  JOURNAL   FASEB J. 5, 331-337 (1991)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             298..2259
                     /standard_name="KCNA4"
                     /standard_name="Kv1.4"
                     /gene="HK1"
                     /product="voltage-gated potassium channel"
                     /codon_start=1
                     /translation="MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAV
                     AAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSF
                     PHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQD
                     EGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNE
                     YFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFV
                     REEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRD
                     DRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA
                     CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVR
                     VFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHF
                     QSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF
                     YHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCA
                     KEEKCQGKGDDSETDKNNCSNAKAVETDV"
BASE COUNT      612 a    563 c    648 g    622 t
ORIGIN      
        1 aacataggtg tctgagagac tccagcattt tcggacttct tagtcttgag agtgccaggc
       61 tatttatctc gaccagccaa gctctggaga gcaatgttga atccctgaga agagagagca
      121 tggggcgtgc tgatttaaaa acagaaaatg caaagttgga ctgaaaatat ccttagtctt
      181 ccaagcaatc tgcttaaggg ttccaaactt accttaattt ggtgagaaaa gaagctgccc
      241 tatttttctt tcttcttctt ctacaactgg aaccagccat ttccgaaaac caccaccatg
      301 gaggttgcaa tggtgagtgc ggagagctca gggtgcaaca gtcacatgcc ttatggttat
      361 gctgcccagg cccgggcccg ggagcgggag aggcttgctc actccagggc agctgcagca
      421 gctgctgttg cagcggccac agctgctgtc gaaggtagcg ggggttctgg tgggggctcc
      481 caccaccacc accagtcacg cggggcctgt acctcccatg accctcagag cagccggggt
      541 agtcggagga ggaggcgaca gcggtctgag aagaagaaag cccactaccg gcagagcagc
      601 ttccctcatt gctctgacct gatgcccagt ggctctgagg agaagatcct gagggagctg
      661 agtgaggagg aggaagatga ggaggaggag gaagaggagg aagaggaggg aaggttttac
      721 tatagtgaag atgaccatgg tgatgagtgt tcctacacgg atctgctgcc tcaggatgag
      781 ggcggtggcg gctacagttc agtccgctac agtgactgtt gtgaacgtgt ggtgataaat
      841 gtgtcaggcc tacgctttga gacccaaatg aaaactctgg cccagtttcc agagactttg
      901 ttgggagacc ctgaaaagag gactcagtac tttgaccctt tgcgcaatga gtattttttt
      961 gacaggaacc gccccagctt tgatgccatc ttgtattatt atcaatcagg aggccgcctg
     1021 aagaggccag tcaatgtccc ctttgatatc ttcactgagg aggtgaagtt ctatcagttg
     1081 ggggaggagg ccctgttgaa gtttcgggag gacgagggct ttgtgagaga agaggaagac
     1141 agggccctcc ccgagaatga atttaaaaag cagatttggc tcctctttga atatccagag
     1201 agctccagtc ctgcaagggg catagccatt gtgtccgtcc tggtcatctt aatctccatt
     1261 gtcatctttt gcctggaaac cttgcctgag tttagggacg acagggatct cgtcatggca
     1321 ctgagtgctg gcgggcatgg tgggttgttg aatgatactt cagcacccca tctggagaac
     1381 tcagggcaca caatattcaa tgaccccttc ttcatcgtgg aaacagtctg tattgtatgg
     1441 ttttcctttg agtttgtggt tcgctgcttt gcttgtccca gccaagcact cttcttcaaa
     1501 aacatcatga acatcattga cattgtctcc attttgcctt acttcatcac actgggcact
     1561 gacctggccc agcaacaggg gggtggcaat ggtcagcagc agcaggccat gtcctttgcc
     1621 atcctcagaa tcattcgtct ggtccgagta ttccggatct tcaaactctc caggcactcc
     1681 aaaggcctgc agatcctggg ccacaccctc agagccagca tgcgggaact gggccttctg
     1741 atcttcttcc tcttcattgg ggtcatcctc ttttctagtg ctgtgtattt tgcagaggcg
     1801 gatgaaccta ctacccattt ccaaagcatc ccagatgcat tttggtgggc tgtggtgacc
     1861 atgacaactg tgggctatgg ggacatgaag cccatcactg tagggggcaa gattgtcggg
     1921 tccctgtgtg ccattgcggg tgtcttaacc attgctttgc cagtgccagt gattgtctct
     1981 aactttaact atttctacca cagagagact gaaaatgagg aacagacaca gctaacgcag
     2041 aatgcagtca gttgtccata cctcccctct aatttgctca agaaatttcg gagctctact
     2101 tcttcttccc tgggggacaa gtcagagtat ctagagatgg aagaaggagt taaggaatct
     2161 ctgtgtgcaa aggaggagaa gtgtcaggga aagggggatg acagtgagac agataaaaac
     2221 aactgttcta atgcaaaggc tgtggagact gatgtgtgaa tctttttcca cctgccactg
     2281 ctcccccctc agcatctcca aatatattta tgcatagaga gtgcagttat gaaaatgaaa
     2341 tatgcaaatg atccaatgca tacagtagta cactatttaa tggttataca tggcataatt
     2401 gttactaaac ttgtattaca tatcaaataa atgatacatc ttgga
//