From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens phosphotyrosyl-protein phosphatase (SH-PTP2) mRNA,
Date: 22 Dec 92 22:54:12 GMT
Distribution: bionet
Checksum: 35048 6

LOCUS       HUMSHPTP2A   2276 bp ss-mRNA            PRI       30-NOV-1992
DEFINITION  Homo sapiens phosphotyrosyl-protein phosphatase (SH-PTP2) mRNA,
            complete cds.
ACCESSION   L03535
KEYWORDS    phosphotyrosyl-protein phosphatase.
SOURCE      Homo sapiens (library: lambda ZAP II, Stratagene) fetus brain cDNA
            to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Freeman,R.M.Jr., Plutzky,J. and Neel,B.G.
  TITLE     Identification of a human src homology 2-containing
            protein-tyrosine-phosphatase: A putative homolog of Drosophila
            corkscrew
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 11239-11243 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           <1..113
     misc_feature    129..428
                     /note="'SH2 domain'"
     misc_feature    447..752
                     /note="'SH2 domain'"
     misc_feature    915..1688
                     /note="'phosphatase domain'"
     3'UTR           1896..>2276
     CDS             114..1895
                     /EC_number="3.1.3.48"
                     /note="'SH-PTP2'"
                     /product="phosphotyrosyl-protein phosphatase"
                     /codon_start=1
                     /translation="MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLS
                     VRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
                     NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGES
                     NDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT
                     TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK
                     NRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCL
                     QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA
                     AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM
                     DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE
                     AQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPT
                     PPCAEMREDSARVYENVGLMQQQKSFR"
BASE COUNT      722 a    458 c    565 g    531 t
ORIGIN      
        1 ctgccccgcg tccggtcccg agcgggcctc cctcgggcca gcccgatgtg accgagccca
       61 gcggagcctg agcaaggagc gggtccgtcg cggagccgga gggcgggagg aacatgacat
      121 cgcggagatg gtttcaccca aatatcactg gtgtggaggc agaaaaccta ctgttgacaa
      181 gaggagttga tggcagtttt ttggcaaggc ctagtaaaag taaccctgga gacttcacac
      241 tttccgttag aagaaatgga gctgtcaccc acatcaagat tcagaacact ggtgattact
      301 atgacctgta tggaggggag aaatttgcca ctttggctga gttggtccag tattacatgg
      361 aacatcacgg gcaattaaaa gagaagaatg gagatgtcat tgagcttaaa tatcctctga
      421 actgtgcaga tcctacctct gaaaggtggt ttcatggaca tctctctggg aaagaagcag
      481 agaaattatt aactgaaaaa ggaaaacatg gtagttttct tgtacgagag agccagagcc
      541 accctggaga ttttgttctt tctgtgcgca ctggtgatga caaaggggag agcaatgacg
      601 gcaagtctaa agtgacccat gttatgattc gctgtcagga actgaaatac gacgttggtg
      661 gaggagaacg gtttgattct ttgacagatc ttgtggaaca ttataagaag aatcctatgg
      721 tggaaacatt gggtacagta ctacaactca agcagcccct taacacgact cgtataaatg
      781 ctgctgaaat agaaagcaga gttcgagaac taagcaaatt agctgagacc acagataaag
      841 tcaaacaagg cttttgggaa gaatttgaga cactacaaca acaggagtgc aaacttctct
      901 acagccgaaa agagggtcaa aggcaagaaa acaaaaacaa aaatagatat aaaaacatcc
      961 tgccctttga tcataccagg gttgtcctac acgatggtga tcccaatgag cctgtttcag
     1021 attacatcaa tgcaaatatc atcatgcctg aatttgaaac caagtgcaac aattcaaagc
     1081 ccaaaaagag ttacattgcc acacaaggct gcctgcaaaa cacggtgaat gacttttggc
     1141 ggatggtgtt ccaagaaaac tcccgagtga ttgtcatgac aacgaaagaa gtggagagag
     1201 gaaagagtaa atgtgtcaaa tactggcctg atgagtatgc tctaaaagaa tatggcgtca
     1261 tgcgtgttag gaacgtcaaa gaaagcgccg ctcatgacta tacgctaaga gaacttaaac
     1321 tttcaaaggt tggacaaggg aatacggaga gaacggtctg gcaataccac tttcggacct
     1381 ggccggacca cggcgtgccc agcgaccctg ggggcgtgct ggacttcctg gaggaggtgc
     1441 accataagca ggagagcatc atggatgcag ggccggtcgt ggtgcactgc agtgctggaa
     1501 ttggccggac agggacgttc attgtgattg atattcttat tgacatcatc agagagaaag
     1561 gtgttgactg cgatattgac gttcccaaaa ccatccagat ggtgcggtct cagaggtcag
     1621 ggatggtcca gacagaagca cagtaccgat ttatctatat ggcggtccag cattatattg
     1681 aaacactaca gcgcaggatt gaagaagagc agaaaagcaa gaggaaaggg cacgaatata
     1741 caaatattaa gtattctcta gcggaccaga cgagtggaga tcagagccct ctcccgcctt
     1801 gtactccaac gccaccctgt gcagaaatga gagaagacag tgctagagtc tatgaaaacg
     1861 tgggcctgat gcaacagcag aaaagtttca gatgagaaaa cctgccaaaa cttcagcaca
     1921 gaaatagatg tggactttca ccctctccct aaaaagatca agaacagacg caagaaagtt
     1981 tatgtgaaga cagaatttgg atttggaagg cttgcaatgt ggttgactac cttttgataa
     2041 gcaaaatttg aaaccattta aagaccactg tattttaact caacaatacc tgcttcccaa
     2101 ttactcattt cctcagataa gaagaaatca tctctacaat gtagacaaca ttatatttta
     2161 tagaatttgt ttgaaattga ggaagcagtt aaattgtgcg ctgtattttg cagattatgg
     2221 ggattcaaat tctagtaata ggctttttta tttttatttt tataccctta accagg
//