From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human leukocyte common antigen T200 (CD45, LCA) gene, exon 33.
Date: 8 Apr 92 10:02:05 GMT
Distribution: bionet
Checksum: 37466     7

LOCUS       HUMLCA35     1375 bp ds-DNA             PRI       08-APR-1992
DEFINITION  Human leukocyte common antigen T200 (CD45, LCA) gene, exon 33.
ACCESSION   M23492 M23527
KEYWORDS    T200 glycoprotein; alternative splicing; cell surface antigen;
            cell surface glycoprotein; phosphoprotein.
SEGMENT     35 of 35
SOURCE      Homo sapiens placenta DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
            antigen)
  JOURNAL   EMBO J. 6, 1251-1257 (1987)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Hall,L.R., Streuli,M., Schlossman,S.F. and Saito,H.
  TITLE     Complete exon-intron organization of the human leukocyte common
            antigen (CD45) gene
  JOURNAL   J. Immunol. 141, 2781-2787 (1988)
  STANDARD  full staff_entry
COMMENT
FEATURES             Location/Qualifiers
     intron          order(M23491:177..216,1..40)
                     /number=32
                     /gene="PTPRC"
     CDS             join(M23461:616..682,M23462:41..67,M23466:41..115,
                     M23467:41..67,M23468:41..259,M23469:41..169,
                     M23470:37..174,M23471:41..160,M23472:41..199,
                     M23473:41..249,M23474:41..101,M23475:41..149,
                     M23476:41..75,M23477:41..150,M23478:41..131,
                     M23479:41..117,M23480:41..77,M23481:41..138,
                     M23482:41..166,M23483:41..198,M23484:41..176,
                     M23485:41..190,M23486:41..131,M23487:41..174,
                     M23488:41..175,M23489:41..163,M23490:41..219,
                     M23491:41..176,41..316)
                     /note="Exons 4, 5 and 6 were spliced out in this version
                     of the protein.  Only partial sequences for those exons
                     were available."
                     /product="T200 glycoprotein"
                     /gene="PTPRC"
                     /codon_start=1
                     /translation="MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLS
                     PSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTC
                     TNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICL
                     KWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNA
                     SKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDK
                     NLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS
                     DNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAY
                     FHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLD
                     EQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKE
                     ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPR
                     DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHK
                     RCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF
                     SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYI
                     LIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQH
                     IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYIN
                     ASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG
                     EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPK
                     ELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEE
                     VVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNE
                     VDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS"
                     /citation=[1]
                     /citation=[2]
     mat_peptide     join(M23462:43..67,M23466:41..115,M23467:41..67,
                     M23468:41..259,M23469:41..169,M23470:37..174,
                     M23471:41..160,M23472:41..199,M23473:41..249,
                     M23474:41..101,M23475:41..149,M23476:41..75,
                     M23477:41..150,M23478:41..131,M23479:41..117,
                     M23480:41..77,M23481:41..138,M23482:41..166,
                     M23483:41..198,M23484:41..176,M23485:41..190,
                     M23486:41..131,M23487:41..174,M23488:41..175,
                     M23489:41..163,M23490:41..219,M23491:41..176,41..313)
                     /product="T200 glycoprotein"
                     /gene="PTPRC"
                     /codon_start=1
                     /citation=[1]
                     /citation=[2]
     exon            41..1335
                     /number=33
                     /gene="PTPRC"
BASE COUNT      468 a    199 c    225 g    483 t
ORIGIN
        1 aactttcttc atgtaatttc ccacttaatt cctttactag gagcaatatc aattcctata
       61 tgacgtcatt gccagcacct accctgctca gaatggacaa gtaaagaaaa acaaccatca
      121 agaagataaa attgaatttg ataatgaagt ggacaaagta aagcaggatg ctaattgtgt
      181 taatccactt ggtgccccag aaaagctccc tgaagcaaag gaacaggctg aaggttctga
      241 acccacgagt ggcactgagg ggccagaaca ttctgtcaat ggtcctgcaa gtccagcctt
      301 aaatcaaggt tcataggaaa agacataaat gaggaaactc caaacctcct gttagctgtt
      361 atttctattt ttgtagaagt aggaagtgaa aataggtata cagtggatta attaaatgca
      421 gcgaaccaat atttgtagaa gggttatatt ttactactgt ggaaaaatat ttaagatagt
      481 tttgccagaa cagtttgtac agacgtatgc ttattttaaa attttatctc ttattcagta
      541 aaaaacaact tctttgtaat cgttatgtgt gtatatgtat gtgtgtatgg gtgtgtgttt
      601 gtgtgagaga cagagaaaga gagagaattc tttcaagtga atctaaaagc ttttgctttt
      661 cctttgtttt tatgaagaaa aaatacattt tatattagaa gtgttaactt agcttgaagg
      721 atctgttttt aaaaatcata aactgtgtgc agactcaata aaatcatgta catttctgaa
      781 atgacctcaa gatgtcctcc ttgttctact catatatatc tatcttatat acttactatt
      841 ttacttctag agatagtaca taaaggtggt atgtgtgtgt atgctactac aaaaaagttg
      901 ttaactaaat taacattggg aaatcttata ttccatatat tagcatttag tccaatgtct
      961 ttttaagctt atttaattaa aaaatttcca gtgagcttat catgctgtct ttacatgggg
     1021 ttttcaattt tgcatgctcg attattccct gtacaatatt taaaatttat tgcttgatac
     1081 ttttgacaac aaattaggtt ttgtacaatt gaacttaaat aaatgtcatt aaaataaata
     1141 aatgcaatat gtattaatat tcattgtata aaaatagaag aatacaaaca tatttgttaa
     1201 atatttacat atgaaattta atatagctat ttttatggaa tttttcattg atatgaaaaa
     1261 tatgatattg catatgcata gttcccatgt taaatcccat tcataacttt cattaaagca
     1321 tttactttga atttctccaa tgcttagaat gtttttacca ggaatggatg tcgct
//