From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human multidrug resistance-associated protein (MRP) mRNA, complete
Date: 29 Dec 92 19:58:12 GMT
Distribution: bionet
Checksum: 46323 10

LOCUS       HUMMRPX      5012 bp ss-mRNA            PRI       10-DEC-1992
DEFINITION  Human multidrug resistance-associated protein (MRP) mRNA, complete
            cds.
ACCESSION   L05628
KEYWORDS    multidrug resistance-associated protein; transporter.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5012)
  AUTHORS   Cole,S.P., Bhardwaj,G., Gerlach,J.H., Mackie,J.E., Grant,C.E.,
            Almquist,K.C., Stewart,A.J., Kurz,E.U., Duncan,A.M. and Deeley,R.G.
  TITLE     Overexpression of a transporter gene in a multidrug-resistant human
            lung cancer cell line
  JOURNAL   Science 258, 1650-1654 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             225..4793
                     /gene="MRP"
                     /citation=[1]
                     /note="putative"
                     /product="multidrug resistance-associated protein"
                     /codon_start=1
                     /translation="MAPTRSGTGMSRGIPATPTSPSAFRTRSSCGCLVFTSGPVFPFY
                     FLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPT
                     LLGITTLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDL
                     FRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGL
                     IVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQP
                     KESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGP
                     QILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIG
                     AVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLW
                     LNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKL
                     YAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
                     ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERR
                     PVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKLSLLSAL
                     LAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPD
                     LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIF
                     ENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEF
                     LRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGD
                     ISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFL
                     FMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSI
                     GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGS
                     LFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHF
                     NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLF
                     AALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE
                     KEAPWQIQETRPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT
                     GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMN
                     LDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALL
                     RKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG
                     EIQEYGAPSDLLQQRGLFYSMAKDAGLV"
BASE COUNT     1063 a   1498 c   1394 g   1057 t
ORIGIN      
        1 ccaggcggcg ttgcggcccc ggccccggct ccctgcgccg ccgccgccgc cgccgccgcc
       61 gccgccgccg ccgccgccag cgctagcgcc agcagccggg cccgatcacc cgccgcccgg
      121 tgcccgccgc cgcccgcgcc agcaaccggg cccgatcacc cgccgcccgg tgcccgccgc
      181 cgcccgcgcc accggcatgg cgctccgggg cttctgcagc gccgatggct ccgacccgct
      241 ctgggactgg aatgtcacgt ggaataccag caaccccgac ttcaccaagt gctttcagaa
      301 cacggtcctc gtgtgggtgc cttgttttta cctctgggcc tgttttcccc ttctacttcc
      361 tctatctctc ccgacatgac cgaggctaca ttcagatgac acctctcaac aaaaccaaaa
      421 ctgccttggg atttttgctg tggatcgtct gctgggcaga cctcttctac tctttctggg
      481 aaagaagtcg gggcatattc ctggccccag tgtttctggt cagcccaact ctcttgggca
      541 tcaccacgct gcttgctacc tttttaattc agctggagag gaggaaggga gttcagtctt
      601 cagggatcat gctcactttc tggctggtag ccctagtgtg tgccctagcc atcctgagat
      661 ccaaaattat gacagcctta aaagaggatg cccaggtgga cctgtttcgt gacatcactt
      721 tctacgtcta cttttccctc ttactcattc agctcgtctt gtcctgtttc tcagatcgct
      781 cacccctgtt ctcggaaacc atccacgacc ctaatccctg cccagagtcc agcgcttcct
      841 tcctgtcgag gatcaccttc tggtggatca cagggttgat tgtccggggc taccgccagc
      901 ccctggaggg cagtgacctc tggtccttaa acaaggagga cacgtcggaa caagtcgtgc
      961 ctgttttggt aaagaactgg aagaaggaat gcgccaagac taggaagcag ccggtgaagg
     1021 ttgtgtactc ctccaaggat cctgcccagc cgaaagagag ttccaaggtg gatgcgaatg
     1081 aggaggtgga ggctttgatc gtcaagtccc cacagaagga gtggaacccc tctctgttta
     1141 aggtgttata caagaccttt gggccctact tcctcatgag cttcttcttc aaggccatcc
     1201 acgacctgat gatgttttcc gggccgcaga tcttaaagtt gctcatcaag ttcgtgaatg
     1261 acacgaaggc cccagactgg cagggctact tctacaccgt gctgctgttt gtcactgcct
     1321 gcctgcagac cctcgtgctg caccagtact tccacatctg cttcgtcagt ggcatgagga
     1381 tcaagaccgc tgtcattggg gctgtctatc ggaaggccct ggtgatcacc aattcagcca
     1441 gaaaatcctc cacggtcggg gagattgtca acctcatgtc tgtggacgct cagaggttca
     1501 tggacttggc cacgtacatt aacatgatct ggtcagcccc cctgcaagtc atccttgctc
     1561 tctacctcct gtggctgaat ctgggccctt ccgtcctggc tggagtggcg gtgatggtcc
     1621 tcatggtgcc cgtcaatgct gtgatggcga tgaagaccaa gacgtatcag gtggcccaca
     1681 tgaagagcaa agacaatcgg atcaagctga tgaacgaaat tctcaatggg atcaaagtgc
     1741 taaagcttta tgcctgggag ctggcattca aggacaaggt gctggccatc aggcaggagg
     1801 agctgaaggt gctgaagaag tctgcctacc tgtcagccgt gggcaccttc acctgggtct
     1861 gcacgccctt tctggtggcc ttgtgcacat ttgccgtcta cgtgaccatt gacgagaaca
     1921 acatcctgga tgcccagaca gccttcgtgt ctttggcctt gttcaacatc ctccggtttc
     1981 ccctgaacat tctccccatg gtcatcagca gcatcgtgca ggcgagtgtc tccctcaaac
     2041 gcctgaggat ctttctctcc catgaggagc tggaacctga cagcatcgag cgacggcctg
     2101 tcaaagacgg cgggggcacg aacagcatca ccgtgaggaa tgccacattc acctgggcca
     2161 ggagcgaccc tcccacactg aatggcatca ccttctccat ccccgaaggt gctttggtgg
     2221 ccgtggtggg ccaggtgggc tgcggaaagt tgtccctgct ctcagccctc ttggctgaga
     2281 tggacaaagt ggaggggcac gtggctatca agggctccgt ggcctatgtg ccacagcagg
     2341 cctggattca gaatgattct ctccgagaaa acatcctttt tggatgtcag ctggaggaac
     2401 catattacag gtccgtgata caggcctgtg ccctcctccc agacctggaa atcctgccca
     2461 gtggggatcg gacagagatt ggcgagaagg gcgtgaacct gtctgggggc cagaagcagc
     2521 gcgtgagcct ggcccgggcc gtgtactcca acgctgacat ttacctcttc gatgatcccc
     2581 tctcagcagt ggatgcccat gtgggaaaac acatctttga aaatgtgatt ggccccaagg
     2641 ggatgctgaa gaacaagacg cggatcttgg tcacgcacag catgagctac ttgccgcagg
     2701 tggacgtcat catcgtcatg agtggcggca agatctctga gatgggctcc taccaggagc
     2761 tgctggctcg agacggcgcc ttcgctgagt tcctgcgtac ctatgccagc acagagcagg
     2821 agcaggatgc agaggagaac ggggtcacgg gcgtcagcgg tccagggaag gaagcaaagc
     2881 aaatggagaa tggcatgctg gtgacggaca gtgcagggaa gcaactgcag agacagctca
     2941 gcagctcctc ctcctatagt ggggacatca gcaggcacca caacagcacc gcagaactgc
     3001 agaaagctga ggccaagaag gaggagacct ggaagctgat ggaggctgac aaggcgcaga
     3061 cagggcaggt caagctttcc gtgtactggg actacatgaa ggccatcgga ctcttcatct
     3121 ccttcctcag catcttcctt ttcatgtgta accatgtgtc cgcgctggct tccaactatt
     3181 ggctcagcct ctggactgat gaccccatcg tcaacgggac tcaggagcac acgaaagtcc
     3241 ggctgagcgt ctatggagcc ctgggcattt cacaagggat cgccgtgttt ggctactcca
     3301 tggccgtgtc catcgggggg atcttggctt cccgctgtct gcacgtggac ctgctgcaca
     3361 gcatcctgcg gtcacccatg agcttctttg agcggacccc cagtgggaac ctggtgaacc
     3421 gcttctccaa ggagctggac acagtggact ccatgatccc ggaggtcatc aagatgttca
     3481 tgggctccct gttcaacgtc attggtgcct gcatcgttat cctgctggcc acgcccatcg
     3541 ccgccatcat catcccgccc cttggcctca tctacttctt cgtccagagg ttctacgtgg
     3601 cttcctcccg gcagctgaag cgcctcgagt cggtcagccg ctccccggtc tattcccatt
     3661 tcaacgagac cttgctgggg gtcagcgtca ttcgagcctt cgaggagcag gagcgcttca
     3721 tccaccagag tgacctgaag gtggacgaga accagaaggc ctattacccc agcatcgtgg
     3781 ccaacaggtg gctggccgtg cggctggagt gtgtgggcaa ctgcatcgtt ctgtttgctg
     3841 ccctgtttgc ggtgatctcc aggcacagcc tcagtgctgg cttggtgggc ctctcagtgt
     3901 cttactcatt gcaggtcacc acgtacttga actggctggt tcggatgtca tctgaaatgg
     3961 aaaccaacat cgtggccgtg gagaggctca aggagtattc agagactgag aaggaggcgc
     4021 cctggcaaat ccaggagaca cgtccgccca gcagctggcc ccaggtgggc cgagtggaat
     4081 tccggaacta ctgcctgcgc taccgagagg acctggactt cgttctcagg cacatcaatg
     4141 tcacgatcaa tgggggagaa aaggtcggca tcgtggggcg gacgggagct gggaagtcgt
     4201 ccctgaccct gggcttattt cggatcaacg agtctgccga aggagagatc atcatcgatg
     4261 gcatcaacat cgccaagatc ggcctgcacg acctccgctt caagatcacc atcatccccc
     4321 aggaccctgt tttgttttcg ggttccctcc gaatgaacct ggacccattc agccagtact
     4381 cggatgaaga agtctggacg tccctggagc tggcccacct gaaggacttc gtgtcagccc
     4441 ttcctgacaa gctagaccat gaatgtgcag aaggcgggga gaacctcagt gtcgggcagc
     4501 gccagcttgt gtgcctagcc cgggccctgc tgaggaagac gaagatcctt gtgttggatg
     4561 aggccacggc agccgtggac ctggaaacgg acgacctcat ccagtccacc atccggacac
     4621 agttcgagga ctgcaccgtc ctcaccatcg cccaccggct caacaccatc atggactaca
     4681 caagggtgat cgtcttggac aaaggagaaa tccaggagta cggcgcccca tcggacctcc
     4741 tgcagcagag aggtcttttc tacagcatgg ccaaagacgc cggcttggtg tgagccccag
     4801 agctggcata tctggtcaga actgcagggc ctatatgcca gcgcccaggg aggagtcagt
     4861 acccctggta aaccaagcct cccacactga aaccaaaaca taaaaaccaa acccagacaa
     4921 ccaaaacata ttcaaagcag cagccaccgc catccggtcc cctgcctgga actggctgtg
     4981 aagacccagg agagacagag atgcgaacca cc
//