From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens GSTM4 gene for glutathione S-transferase
Date: 28 Dec 92 21:43:22 GMT
Distribution: bionet
Checksum: 15160 9

LOCUS       HUMGSTM5     4842 bp ds-DNA             PRI       02-DEC-1992
DEFINITION  H.sapiens GSTM4 gene for glutathione S-transferase
ACCESSION   X68677
KEYWORDS    GSTM16 gene; drug metabolism; transferring capacity;
            transforming capacity.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4842)
  AUTHORS   Zhong,S., Spurr,N.K., Hayes,J.D. and Wolf,C.R.
  TITLE     Deduced amino acid sequence, gene structure and chromosomal
            location; novel human class mu glutathione S-transferase (GSTM4)
  JOURNAL   Biochem. J. (1992) In press
  STANDARD  full automatic
COMMENT     *source: stage=adult; *source: cell_type=lymphoblastoid; *source:
            cell_line=human transformed lymphoblastoid, GST6; *source: clone=
            phGSTM4-1 & phGSTM4-2; *source: isolate=GST6; *source: chromosome=
            1p;
               From EMBL    entry HSGSTM4;  dated 26-OCT-1992.
FEATURES             Location/Qualifiers
     exon            <1..36
                     /number=1
     mRNA            join(<1..36,315..390,809..873,1180..1261,1357..1457,
                     2373..2468,2559..2669,4753..>4842)
                     /gene="GSTM4"
                     /partial
     intron          37..314
                     /number=1
     exon            315..390
                     /number=2
     intron          391..808
                     /number=2
     exon            809..873
                     /number=3
     intron          874..1179
                     /number=3
     exon            1180..1261
                     /number=4
     intron          1262..1356
                     /number=4
     exon            1357..1457
                     /number=5
     intron          1458..2372
                     /number=5
     exon            2373..2468
                     /number=6
     intron          2469..2558
                     /number=6
     exon            2559..2669
                     /number=7
     intron          2670..4752
                     /number=7
     exon            4753..>4842
                     /number=8
     CDS             join(1..36,315..390,809..873,1180..1261,1357..1457,
                     2373..2468,2559..2669,4753..4842)
                     /EC_number="2.5.1.18"
                     /gene="GSTM4"
                     /product="glutathione S-transferase"
                     /codon_start=1
                     /translation="MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGGAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QAMDVSNQLARVCYSPDFEKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLA
                     YDVLDLHRIFEPNCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPKPLYTRMAVWGNK
                     "
BASE COUNT     1021 a   1220 c   1331 g   1270 t
ORIGIN      
        1 atgcccatga tactggggta ctgggacatc cgcggggtga gtgagggtcc gctgcactgt
       61 gggaccgggc gcgtgggcgg gaagtgccga gcggctgggg accggctcta gggacggtac
      121 cctccttagg gctatctctc acaggagggc ctgtgcatgc ctgtgtgtgt gtgtgtgtgt
      181 gtgtgtgtgt gtgtgcatac accggggtgg gggggggtgc agtgcaggta gactaggggc
      241 tcacctggtg cagagaaagt caccaagtca gggaccctcc atctctgaca cgacctgcgg
      301 gccatctctt ccagctggcc cacgccatcc gcctgctcct ggaatacaca gactcaagct
      361 acgaggaaaa gaagtatacg atggggggcg gtaatggcac cctcgagtct gggccctgcc
      421 ctcacactaa gttggcacca agcaaccgat agtggccacc tgtcggtgac tctgcaggcc
      481 tcccttgctg gaactgcagg ctgtcccttc cctgagccct ggtgagggag ctccttgcaa
      541 ggcagaatgc tggggcggga tgctgggccc ccgtctggta attatgatgg gtgtcctcag
      601 gcttgcctaa ccctggaagc cttagctgtg tggggtccag agccctcact ggaattcttt
      661 ttctctgaat cctgggatgt ggggctgagt ggtcagattc tagatccacc tgtctcaggg
      721 gtcttcgcac tggctccttg ggagggtccc caggaaggag ggctgggctt tggggaggtt
      781 tgttttcact tcttcttccc cacggcagct cctgactatg acagaagcca gtggctgaat
      841 gaaaaattca agctgggcct ggactttccc aatgtaggtg caggggaagg ggcgttttgg
      901 gggaaagtgc gacgtgtctc tgactgcatc tcctctcccc agattagagg tgttcggatc
      961 aggagtcttc tgcccaattc ctctcactcc tggttgtcta cacagcccct gcatgatgtt
     1021 ctgtgtccca gctcatttgt tcatgtgaca gtatttctat gtcaggcctg ccatgagcgg
     1081 cacagtggtg cctggtctcc cctctgccct tgatatggga aggagatgct ggggagcctg
     1141 ctggcccaac tgagcttccc cggtttccca tctatccagc tgccctacct gattgatggg
     1201 gctcacaaga tcacccagag caacgccatc ctgtgctaca ttgcccgcaa gcacaacctg
     1261 tgtgagtgtg ggtggctgca atgtgcgggg ggacggtgac ctcctccttg gctgggctgt
     1321 gatgctgaga ttgagtctgt gttttgtggg tggcaggtgg ggagacagaa gaggagaaga
     1381 ttcgtgtgga cattttggag aaccaggcta tggacgtctc caatcagctg gccagagtct
     1441 gctacagccc tgactttgtg agtccccccc tggtctggac cagaagccag gcttgtattc
     1501 ccatctactc tggtcctatt cacaatttga actcctcact gctattgatc ctctgagggt
     1561 tccctgtact gtagcagagt gactgtcata tcattaaact tataaaataa aaacttgaaa
     1621 tcagtcccac caatcatagg aagtcctatg aaagctagca attcagttcc tagacaataa
     1681 agtcatgcgt tcagaattcc cttcccctct gacccctgac ctctgccacg ggccatctaa
     1741 cccagttcgg ttcatgcggg gaatacgcag actcacacta tggggtaaag aagtatgtag
     1801 tgggatgtaa tagcaccctc ctctgtggaa ttccgtgcta ttcttttcct agtgcttctc
     1861 cttgacacgc acagggatga atgcattttc ctaacaggca gctcagggtg gcagagggcc
     1921 ttttgttcct ctgtctcctt ccatgcagcc tctcaaaatc tcatctctcc agaaactact
     1981 caatgtccat tgtattattc tgccactgca ctaggaggaa ctttcaactt ctttctctga
     2041 gctcctttag ttctttgtat ccttgatttg ctcgtgtctg ggtccagagc ctgccaggta
     2101 ctcaggtctc ctgggctcac ccagaggagg gtggttggga ggtcagtggg acagattcag
     2161 gatagtgttg cattcctcgc cttcccatca ccacaaagcc tccagctacc attggagtgt
     2221 aataaatgat ggtatgtcca gctgaagcca gttccagctg tgggaagatg gctgcttgct
     2281 cgtggccagc tgggccatac acagccctgg ggaggccaca tctgtgcagg gagcttgtgt
     2341 ctgagggtgg tgacagctgt tttctgcctc aggagaaact gaagccagaa tacttggagg
     2401 aacttcctac aatgatgcag cacttctcac agttcctggg gaagaggcca tggtttgttg
     2461 gagacaaggt aatgggggca tgtgataagg acactagaga tttgccatac atcctatgtt
     2521 acagagattc cagcccacac attcttggcc ttctgcagat cacctttgta gatttcctcg
     2581 cctatgatgt ccttgacctc caccgtatat ttgagcccaa ctgcttggac gccttcccaa
     2641 atctgaagga cttcatctcc cgctttgagg tgatgccccc atcctccttt ctctttgatg
     2701 ccccttgttc cgttacctcc tttcagatgc tttcccagtc ctggatctgc ataaagaata
     2761 acttgcattt actgagtgct ggacttcatg caggaacctt gcccagcaca ttatacctat
     2821 cgtgtggaat ttgaaatttc caacattcct acagggtgac agaattatct tgcccattta
     2881 gagataagaa aactttgaat gagagggtca gtcctttgtt ctgggtccca gagccagtgg
     2941 aggctgtgct gggctccctg tgagcatctg gatctatggg tggcagtcag ggctctccct
     3001 tttgtgacaa aagaaagaag cctcaccctc atccagcctg gatttcacag cccaggcact
     3061 ttggaagagg cagagaactt taggagcatg gatgcacctg gcaatagtag gactgacaca
     3121 ccttcgcatt gacctcgagt acgaacccca caggcagtat tcatagctac tcccagaagc
     3181 tttgcacgat cagaccccca cgtgggaatc ctgagagcca gagctgtggc cagagctgga
     3241 ttagggtaca tatgtgggtg cccctgttga aggagtgtat gttgaagtgc tctgtgctgg
     3301 ggcactcttc cttctttatc ttttttcctc tcttttttcc ctccagtgtt ccaagtgttc
     3361 accctgtgag atgagtagca cactgatttt actgctatca ccgaccttct cctctgcatg
     3421 aggcagggtg tgaggcacag tgggagttgc atagatgact gccccatcct ggaaatgagt
     3481 gcagtgagag gcctgcagcg agaccagcct gtgaggtgtg tggcacactg ggtaccgacc
     3541 tgggctcccc tacactcatg gggaacatcc tacaaccgtg ctgaatttgt ttgagagcag
     3601 caaatctact tttagtacag atgtgagaat ttgaggcatt agtccaacaa gtttttcaga
     3661 cctaaaattt gttttccttt cccactaccc atcaagggat ctggttactc agctagttcc
     3721 catcagctct ggctgtggtc gtcggctgag tggccttggg gttatgtaag aggtagtgga
     3781 ggggaagaga gctgaggctg cagatatggt ccacctgctt ggcctttggg ataggcagcc
     3841 ctggctctct ctgaatcctt agaaattaca cggctatttg atcccggaag atctggcaga
     3901 gcacacctga gtgtcataca gcctggtctg aggtagtggg gctggagatg aggtgggttg
     3961 gggcacagtg gtgtttagct caggtaccag gtggggaggt ttagactttc tgctttaaaa
     4021 ggaatgatta gagcctggtc tggcgtttct tttgctggtc caacacacct tgaccacttt
     4081 catccaggtt ttgccaggtc cttccctgag atctgggctc tcttccaggc tgcacagaca
     4141 ttttcacagg tcccctctgt gtgtgcaaac ctagcaagcc aggtgcctcc tgtgaaacag
     4201 gagaatgttg tgtagtcaga gagtgacagg acctcctgag ggatttgggg gaggatgggg
     4261 atttgacaga aagaggccag aactggagag agacagaacc agtctacgtt gcagctctgt
     4321 cccccttagt agctatttga gtgtgaggaa gtactgaact tctgttccac atgagaaatg
     4381 gtgatataga ttcagccttg caggtagtcg agtggtttct aagcttatgt tgtaatttct
     4441 cttggtacag agcacccagc accgtgtaga atcttcataa gtgttagatg ttactgtggt
     4501 acaacattac ttaaggaagt tggaagagtt aactccgcaa atctggggac cctaagaggc
     4561 tgtgtgatgc ctcagcactt gagcccacgt ggaaaggctg tgccagggcc ctgacctgct
     4621 gtgtctgcag tggggttgtc ccacgccgtg aagctgtgac agggaccctg acctgctgtg
     4681 tctgcagtgg ggttgtccca agcctcatgg gcagctgacc ttgagttctg gccttatttt
     4741 cccccctctc agggcttgga gaagatctct gcctacatga agtccagccg cttcctccca
     4801 aaacctctgt acacaaggat ggctgtctgg ggcaacaagt ag
//