From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human Ig germline H-chain (V71-2) gene V-region, exons 1 and 2.
Date: 12 Sep 92 10:02:33 GMT
Distribution: bionet
Checksum: 17511     4

LOCUS       HUMIGHVV2    1212 bp ds-DNA             PRI       12-SEP-1992
DEFINITION  Human Ig germline H-chain (V71-2) gene V-region, exons 1 and 2.
ACCESSION   M29811
KEYWORDS    constant region; germline; immunoglobulin heavy chain;
            variable region.
SEGMENT     2 of 7
SOURCE      Homo sapiens placenta DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Kodaira,M., Kinashi,T., Umemura,I., Matsuda,F., Noma,T., Ono,Y. and
            Honjo,T.
  TITLE     Organization and evolution of variable region genes of the human
            immunoglobulin heavy chain
  JOURNAL   J. Mol. Biol. 190, 529-541 (1986)
  STANDARD  simple staff_review
FEATURES             Location/Qualifiers
     CDS             join(151..196,279..587)
                     /gene="IGH@"
                     /codon_start=1
                     /translation="MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVS
                     GGSVSSGSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLK
                     LSSVTAADTAVYYCAR"
                     /partial
     sig_peptide     join(151..196,279..289)
                     /gene="IGH@"
                     /codon_start=1
     intron          197..278
                     /note="IgH, intron A"
                     /gene="IGH@"
     mat_peptide     290..588
                     /gene="IGH@"
                     /codon_start=1
                     /partial
     iDNA            589..>1212
                     /note="V-D intervening DNA (5' end put.)"
                     /gene="IGH@"
                     /note="putative"
BASE COUNT      293 a    314 c    306 g    299 t
ORIGIN      About 4.2 kb after segment 1.
        1 cctccttttt cacctctccg tacaaaggca ccacccacat gcaaatcctt acttaagcac
       61 ccacaggaaa ccaccacaca tttccttaaa ttcaggttcc agctcacatg ggaaatactt
      121 tctgagagcc tggacctcct gtgcaagaac atgaaacacc tgtggttctt cctcctcctg
      181 gtggcagctc ccagatgtga gtgtctcagg gatccagaca tgggggtatg ggaggtgcct
      241 ctgatcccag ggctcactgt gggtctctct gttcacaggg gtcctgtccc aggtgcagct
      301 gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcactgt
      361 ctctggtggc tccgtcagca gtggtagtta ctactggagc tggatccggc agcccccagg
      421 gaagggactg gagtggattg ggtatatcta ttacagtggg agcaccaact acaacccctc
      481 cctcaagagt cgagtcacca tatcagtaga cacgtccaag aaccagttct ccctgaagct
      541 gagctctgtg accgctgcgg acacggccgt gtattactgt gcgagagaca cagtgagggg
      601 aggtgagtgt gagcccagga cacaaacctc cctcatggac gcggagggga ccggcgcagg
      661 tgctgctcag gaccagcagg tggcgcgcgg ggcccccaga gcatgaggcc gggtcaggac
      721 aggtgcaggg agggcttcct catctgctca ctggtctccg tcctcgccag cacctcgctg
      781 tcaccagggc tcctctttct ttattatctg tggttctgct tcctcacatt cttgtgccag
      841 gaaagaaacg aggaagacgg gttttcgtct atagttgaag cttttactag gatcttgcct
      901 acaagttcct gcatgaccca ttataactta tcgattaaaa aatatatatt ctaatgcttc
      961 tcaccatctc ttgatttgta tcatcaactg aattgtaccc tctttgaaat tcatatgatg
     1021 aaaccttaaa ttcaatggat ctatattgga attttaatga aataattaag gttaaatgtg
     1081 gtcataattg taagacccta atgcaataga cgtgttgtct ttataagaag aggaagagac
     1141 accagagacc tctcactttt cacgtgcagg cagagaagag gccatgtgga gacatagtgc
     1201 actagaaggt gg
//