From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Abelson murine leukemia virus genome with v-abl oncogene. The virus
Date: 29 Dec 92 01:01:10 GMT
Distribution: bionet
Checksum: 18204 11

LOCUS       MLAAMLV      5893 bp ds-DNA             VRL       04-DEC-1992
DEFINITION  Abelson murine leukemia virus genome with v-abl oncogene. The virus
            is shown as integrated in the murine genome. It has two reading
            frames and long terminal repeats.
ACCESSION   V01541 J02009
KEYWORDS    oncogene; terminal repeat.
SOURCE      Abelson murine leukemia virus DNA.
  ORGANISM  Abelson murine leukemia virus
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Retroviridae; Oncovirinae; Type C oncovirus group; Mammalian type C
            oncoviruses; Murine leukemia viruses.
REFERENCE   1  (bases 1 to 5893)
  AUTHORS   Reddy,P.E., Smith,M.J. and Srinivasan,A.
  TITLE     Nucleotide sequence of Abelson murine leukemia virus genome:
            Structural similarity of its transforming gene product to other onc
            gene products with tyrosine-specific kinase activity
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 80, 3623-3627 (1983)
  STANDARD  full automatic
COMMENT     SWISS-PROT; P00521; KABL_MLVAB. SWISS-PROT; P03333; GAG_MLVAB.
            SWISS-PROT; P03400; V18K_MLVAB.
               From EMBL    entry REAMLV;  dated 06-DEC-1983.
FEATURES             Location/Qualifiers
     cellular        <1..79
                     /note="extent of cellular DNA"
     LTR             80..669
                     /note="long terminal repeat left"
     mRNA            527..5661
     LTR             5148..5737
                     /note="long terminal repeat right"
     cellular        5737..>5893
                     /note="extent of cellular DNA"
     CDS             1147..3903
                     /gene="oncogene v-abl"
                     /codon_start=1
                     /translation="MGQTVTTPLSLTLGHWKDVERIAHNQSVDVKKRRWVTFCSAEWP
                     TFNVGWPRDGTFNRDLITQVKIKVFSPGPHGHPDQVPYIVTWEALAFDPPPWVKPFVH
                     PKPPPPLPPSAPSLPLEPPLSTPPRSSLYPALTPSLGAKPKPQVLSDSGGPLIDLLTE
                     DPPPYRDPRPPPSDRDGNGGEATPAGEAPDPSPMASRLRGRREPPVADSTTSQAFPLR
                     TGGNGQLQYWPFSSSDLYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESE
                     SSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTL
                     HYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK
                     TLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRE
                     CNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRL
                     MTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDL
                     SQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSIS
                     DEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKASPPSLTPKLLRRQVTASP
                     SSGLSHKKEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSESPGRD
                     KGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDPTKA
                     GPPGEGLRKPVPPSVPKPQSTAKPQGLPPARSPPPPQHQLLHPWLGTSSHLLPPSSPS
                     YQPVCLLGRPASRQSALPVAPSPRVWFWTVLRPCALPSPGTQSRWPATVLYWRLARTC
                     TLSV"
     CDS             4233..4724
                     /note="unidentified reading frame"
                     /codon_start=1
                     /translation="MEPGGVGSSSCVVHQLPCTFPAQPRRQPPLLTACGWVSCSEDYI
                     WPAWPPGFSLPGASDPAPRSAWSALPCPCRTTSSDGPSCHQGMGAPVLTVPAPLMLTN
                     CPREPVLTVFSLEGSCRFKGHEVLKPGAQMGGHWKQELGSVVCHLLSVSSAVCPADLG
                     QQA"
BASE COUNT     1361 a   1703 c   1550 g   1279 t
ORIGIN      
        1 cccaagcaat taatttcaat ggggtcagta aggagcaccc tgcagtcttg aaaactgtat
       61 atctttgcac gattctgggt gaaagacccc acctgtaggt ttggcaagct agcttaagta
      121 acgccatttt gcaaggcatg gaaaaataca taactgagaa tagagaagtt cagatcaagg
      181 tcaggaacag agaaacagct gaatatgggc caaacaggat atgctgtggt aagcagttcc
      241 tgccccggct cagggccaag aacagttgga acagctgaat atgggccaaa caggatatct
      301 gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggtcccca gatgcggtcc
      361 agccctcagc agtttctaga gaaccatcag atgtttccag ggtgccccaa ggacctgaaa
      421 tgaccctgtg ccttatttga actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct
      481 tctgctcccc gagctcaata aaagagccca caacccctca ctcggcgcgc cagtcctccg
      541 agtgactgag tcgcccgggt acccgtgtat ccaataaacc ctcttgcagt tgcatccgac
      601 ttgtggtctc gctgttcctt gggagggtct cctctgagtg attgactacc cgtcagcggg
      661 ggtctttcat ttgggggctc gtccgggatc gggagacccc tgcccaggga ccaccgaccc
      721 accaccggga ggtaagctgg ccagcaactt atctgtgtct gtccgattgt ctagtgtcta
      781 tgactgattt tatgcgcctg cgtcggtact agttagctaa ctagctctgt atctggcgga
      841 cccgtggtgg aactgacgag ttcggaacac ccggccgcaa ccctgggaga cgtccaaggg
      901 acttcggggg ccgtttttgt ggcccgacct gagtccaaaa atcccgatcg ttttggactc
      961 tttggtgcac cccccttaga ggagggatat gtggttctgg taggagacga gaacctaaaa
     1021 cagttcccgc ctccgtctga atttttgctt tcggtttgga accgaagccg cgccgcgcgt
     1081 cttgtctgct gcagcatcgt tctgtgttgt ctctgtctga ctgtgtttct gtagttgtct
     1141 gaaaatatgg gccagactgt taccactccc ttaagtttga ctttaggtca ctggaaagat
     1201 gtcgagcgga tcgctcacaa ccagtcggtt gatgtcaaga agagacgttg ggttaccttc
     1261 tgctctgcag aatggccaac ctttaacgtc ggatggccgc gagacggcac ctttaaccga
     1321 gacctcatca cccaggttaa gatcaaggtc ttttcacctg gcccgcatgg acacccagac
     1381 caggtcccct acatcgtgac ctgggaagcc ttggcttttg acccccctcc ctgggtcaag
     1441 ccctttgtac accctaagcc tccgcctcct cttcctccat ccgccccgtc tctccccctt
     1501 gaacctcctc tttcgacccc gcctcgatcc tccctttatc cagccctcac tccttctcta
     1561 ggcgccaaac ctaaacctca agttctttct gacagtgggg ggccgctcat cgacctactt
     1621 acagaagacc ccccgcctta tagggaccca agaccacccc cttccgacag ggacggaaat
     1681 ggtggagaag cgacccctgc gggagaggca ccggacccct ccccaatggc atctcgcctg
     1741 cgtgggagac gggagccccc agtggccgac tccactacct cgcaggcatt ccccctccgc
     1801 acaggaggaa acggacagct tcaatactgg ccgttctcct cttctgacct ttacatcacc
     1861 cccgtcaaca gcctggagaa acattcctgg tatcatggcc ctgtatctcg gaatgctgct
     1921 gagtatctgc tgagcagcgg aatcaacggc agcttcttag tgcgggagag tgagagtagc
     1981 cctggccaga gatccatctc gctgcggtat gaagggaggg tgtaccacta caggatcaac
     2041 actgcctctg atggcaagct gtacgtgtcc tccgagagcc gcttcaacac tctggctgag
     2101 ttagttcacc atcactccac ggtggctgat ggcctcatca ccacactcca ctacccagct
     2161 cccaagcgca acaagcccac tatctacggt gtgtccccca actacgacaa gtgggaaatg
     2221 gagcgcaccg acatcaccat gaagcacaag ttgggtggag gccagtacgg ggaggtgtac
     2281 gagggcgttt ggaagaagta cagcctcact gtggccgtga agaccttgaa ggaggacacc
     2341 atggaggtgg aggagttcct gaaggaagcg gcggtgatga aggagatcaa acaccctaac
     2401 ctggtgcagc tgctaggggt gtgtacccgg gaaccaccat tctacataat cactgagttc
     2461 atgacctatg ggaacctgct ggactacctg agggagtgta accggcagga ggtgagcgcc
     2521 gtggtactgc tctacatggc cacacagatc tcatcagcca tggagtactt ggagaagaag
     2581 aacttcatcc acagagacct tgctgcccgg aactgcctgg taggggaaaa ccacttggtg
     2641 aaggtggctg attttggcct gagcaggttg atgacagggg acacctacac ggcccatgct
     2701 ggagccaaat tccccatcaa atggaccgca cctgagagcc tggcctacaa caagttctcc
     2761 atcaagtcgg acgtgtgggc atttggagta ttgctctggg agattgctac ctatggcatg
     2821 tcaccttacc cgggaattga cctgtctcag gtttatgagc tgctggaaaa agactaccgc
     2881 atggagcgcc ctgaaggctg cccggagaag gtctacgagc tcatgcgagc atgttggcag
     2941 tggaacccct ctgaccggcc ctcctttgct gaaatccacc aagcctttga aaccatgttc
     3001 caggaatcca gtatctcaga tgaggtggag aaggagctgg ggaaacgagg cacgagagga
     3061 ggtgctggga gtatgctgca ggccccagag ctgcccacca agaccagaac ctgcaggaga
     3121 gcagctgagc agaaagccag ccctcccagc ttgactccca aactcctccg caggcaggtc
     3181 actgcctctc cttcctctgg cctctctcac aagaaagagg ccaccaaggg cagtgcctca
     3241 ggcatgggga ctccggccac tgcagagcca gcacccccca gcaacaaagt gggcctcagc
     3301 aaggcctcct ctgaggagat gcgcgtaagg aggcacaagc acagctcgga gtccccaggg
     3361 agagacaagg ggcgactggc taagctcaag cctgccccgc cgcctcctcc tgcctgcaca
     3421 ggaaaagcag gcaagcccgc acagagcccc agccaagagg ccggggaggc aggggggccc
     3481 acaaagacaa aatgcacgag tctggctatg gatgctgtga acactgaccc caccaaggcc
     3541 ggcccacctg gagaaggact gagaaagcct gtgcccccat ctgtgccaaa gccccagtcg
     3601 acggctaagc ctcagggact cccaccagcc cggtctccac cccctccaca gcaccagctc
     3661 cttcacccct ggctggggac cagcagccat cttctgccgc cttcatcccc ctcatatcaa
     3721 cccgtgtgtc tcttaggaag acccgccagc cgccagagcg cattgccagt ggcaccatca
     3781 ccaagggtgt ggttctggac agtactgagg ccctgtgcct tgccatctcc cggaactcag
     3841 agcagatggc cagccacagt gctgtactgg aggctggcaa gaacctgtac actttctgtg
     3901 tgagctatgt ggactctatc cagcagatga ggaacaagtt tgccttccgt gaggctatca
     3961 acaagctgga gagcaacctc cgagagctgc agatctgccc tgccacagcc tccagtgggc
     4021 cagctgccac ccaagacttc agcaagctgc tcagctctgt gaaggagatc agcgacattg
     4081 tccggaggta gcagcaacca gtgtatgtca gcaagagatg ttgcagttca cagggctctt
     4141 gtgcctataa agatggggac aggggactgg ggagctggcg tctttcccca ggagctttaa
     4201 agagagacaa gcagagcctg agggagacct ggatggagcc tggtggagtt ggctcttcct
     4261 cctgtgttgt gcaccagctg ccctgcacct ttcctgccca gcccaggcgt cagccacctc
     4321 tcctcactgc ctgtggatgg gtctcctgct ctgaagacta catctggcct gcctggccac
     4381 caggcttctc actccccggt gcctcagacc cagctcccag gtcagcctgg agtgctcttc
     4441 cctgtccttg cagaacgacc tcctctgatg gaccttcttg tcaccaaggc atgggagccc
     4501 ctgtgcttac tgtacctgca cctttgatgc ttacaaactg tccccgagag cctgtgctca
     4561 ctgtgttttc attggaagga agctgtcgct ttaagggtca tgaggtgcta aagccagggg
     4621 cccagatggg tgggcactgg aaacaggagc tgggcagtgt ggtctgtcac ctgctctcag
     4681 tatcttcagc agtgtgcccg gcagatcttg gacagcaagc ttgagtttta tgggtggcag
     4741 tcactggctg gctaggcaca tagccaggcc aaacctaggc ctccaagggc tccccaaaat
     4801 ctgaatttct gagtagtctt catcccctct cctgctctaa ggtcaggtcc atcctctctg
     4861 gtccttacct tgatgacaag gatccagcct tctggtgttt ttgagcattt caaaggtctg
     4921 catagaaagg aacagccact aggtccatta tgggacccct cattgtactc ctaatgattt
     4981 tgctcttcgg accctgcatt cttaatcgat tagtccaatt tgttaaagac aggatatcag
     5041 tggtccaggc tctagttttg actcaacaat atcaccagct gaagcctata gagtacgagc
     5101 catagataaa ataaaagatt ttatttagtc tccagaaaaa gggggaatga aagaccccac
     5161 ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga aaaatacata
     5221 actgagaata gagaagttca gatcaaggtc aggaacagag aaacagctga atatgggcca
     5281 aacaggatat gctgtggtaa gcagttcctg ccccggctca gggccaagaa cagttggaac
     5341 agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc
     5401 aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga accatcagat
     5461 gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca
     5521 gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctcaataaa agagcccaca
     5581 acccctcact cggcgcgcca gtcctccgag tgactgagtc gcccgggtac ccgtgtatcc
     5641 aataaaccct cttgcagttg catccgactt gtggtctcgc tgttccttgg gagggtctcc
     5701 tctgagtgat tgactacccg tcagcggggg tctttcatgg gtaacagttt cttgaagttg
     5761 gagaacaaca ttctgagggt aggagtcgaa tattaagtaa tcctgactca attagccact
     5821 gttttgaatc cacatactcc aatactcctg aaatagttca ttatggacag cgcagaagag
     5881 ctggggagaa ttc
//