From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mus musculus neuronal dihydropyridine-sensitive L-type calcium
Date: 26 Jan 93 05:48:34 GMT
Distribution: bionet
Checksum: 56120 16

LOCUS       MUSDHPCC     9014 bp ss-mRNA            ROD       25-JAN-1993
DEFINITION  Mus musculus neuronal dihydropyridine-sensitive L-type calcium
            channel alpha-1 subunit mRNA, complete cds.
ACCESSION   L01776
KEYWORDS    L-type calcium channel; dihydropyridine-sensitive calcium channel;
            neuronal calcium channel alpha-1 subunit.
SOURCE      Mus musculus (strain BALB/c, sub_species domesticus) (library:
            lambda GT11) adult brain cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 9014)
  AUTHORS   Ma,W.-J., Holz,R.W. and Uhler,M.D.
  TITLE     Expression of a cDNA for a neuronal calcium channel alpha 1 subunit
            enhances secretion from adrenal chromaffin cells
  JOURNAL   J. Biol. Chem. 267, 22728-22732 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..1166
     misc_difference replace(1120,"t")
                     /note="sequence difference between two clones"
     misc_difference replace(3505..3506,"accggccag")
                     /note="splicing variation within a clone"
     3'UTR           7587..9014
     misc_difference replace(8238..8239,"ggagg")
                     /note="sequence insertion within a clone"
     CDS             1167..7586
                     /evidence="EXPERIMENTAL"
                     /product="L-type calcium channel alpha-1"
                     /codon_start=1
                     /translation="MVNENTRMYVPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
                     TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATRPPR
                     ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
                     RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
                     DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
                     FVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKP
                     GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFG
                     SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
                     NEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
                     WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLAL
                     FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRL
                     LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
                     QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
                     NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKPAVEE
                     SKEEKIELKSITADGESPPTTKINMDDLQPSENEDKSPHSNPDTAGEEDEEEPEMPVG
                     PRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSS
                     ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL
                     DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
                     NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
                     RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
                     IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
                     KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
                     TVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEEN
                     SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG
                     MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE
                     PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL
                     DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS
                     DGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD
                     DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRA
                     ISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQR
                     PLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGY
                     SSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVNQEIFPDETRSVRMSE
                     EAEYCSEPSLLSTDMFSYQEDEHRQLTCPEEDKREIQPSPKRSFLRSASLGRRASFHL
                     ECLKRQKDQGGDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVTP
                     GSRGRPLRPIPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGSSSMARRARPVSL
                     TVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM
                     ENAADNILSGGAQQSPNGTLLPFVNCRDPGQDRAVAPEDESCAYALGRGRSEEALADS
                     RSYVSNL"
BASE COUNT     2087 a   2439 c   2375 g   2113 t
ORIGIN      
        1 gtgtgttgca catgtctgtg tgagtacagg cacacatgtg catgcaagtg gttgcagaag
       61 gcagaagatc actttggatc ccttggggct ggagttatag gtgcttgtga gccaccagac
      121 atggtacttg taattgagaa gcaagtggtc ccaaccacag tgccatctct ccagctccca
      181 ctttctttct ttttgaccac aactctcccc tttataaaag aggaagaaag ttattcccaa
      241 gccggggaaa cactcacaac aggctccttc ttttaactta gtggagaagt cggggcagcc
      301 tcaaaaacag tgagtaggtc acaactctag tactctacta agcacttgag caaattacaa
      361 gatagcaatt ggtatgcagg agccaaagta tgatgagggt tggatgagca tgtgctaagc
      421 acagccatcc tcttttgtct taattggagc agatatactg caagcctctc tctgtctaga
      481 gataacgttt attttatttg gatgcatgag tattttgctt acatgtatgt atgggtacta
      541 tgtgtgtgcc tggagcctgc agtggtcacg agaggggatc agatcccatg gaacggagct
      601 cggcgcggcg cggcccggag cggcggcggc agtggcggcg gcggcgacgc ttcccgcggg
      661 ctcgccctca ggtgttcgcg gctgccgtcg ccgaagatcg cgggtcgggg cctcgcggcg
      721 atcgccctgg gcgggccgga gacgcctcgg gccccctggc ggctcggggt ccacccggcg
      781 ccgcgggccc gccgctttcc ctcgcctcgc ctttgcgcct cttctcgctc tgcctctcca
      841 tttattattc ttatcatttt tattttcaaa tggtgtagcc gccagaggtg cggtgctaaa
      901 ttcttggaag gggcccggat gtactgagga tgcattacaa tctcacgaaa ggaggcggta
      961 gtggaaagca gcagtttttg gtgtttggtg caataatggg gatcaggtaa tcacccgaag
     1021 ggagcaagaa ccactgcgga tccacggctt cctggatttg cgcgagagcc gccggcctcg
     1081 gaggagggat ccatcccgag ccgctcgcgg ctgttgctgc atttcttcct ctttgtggct
     1141 tctcctttcc aagcagtttt tggccaatgg tcaatgaaaa cacgaggatg tacgttccag
     1201 aggaaaacca ccaaggttcc aactatggga gcccacgccc agctcatgcc aacatgaatg
     1261 ccaatgcagc tgcaggactt gctcccgagc acatccctac tccaggggca gcactgtcct
     1321 ggcaggcagc catcgatgcc gcccggcagg ccaagctcat gggcagtgct ggcaacgcaa
     1381 ccatctctac cgtcagttcc acacagcgga agcggcagca gtatgggaaa cccaagaagc
     1441 aggggggcac aaccgccaca cggccgcccc gggctctgct gtgtctgacc ctgaagaacc
     1501 ctatccggag ggcgtgcata agcattgttg aatggaaacc atttgaaatc attattttac
     1561 tgactatttt tgccaattgt gtggccttag caatctatat tccctttccg gaagacgact
     1621 ccaacgccac caactccaac ctggaacgag tggagtatct cttcctcatc atttttaccg
     1681 tggaagcatt tttaaaagta attgcctacg gacttctctt ccaccccaac gcttacctcc
     1741 gcaatggttg gaatttactg gattttataa tcgtggttgt agggcttttt agtgcaattt
     1801 tagaacaagc aaccaaagct gatggggcca atgctctagg agggaaagga gctggattcg
     1861 acgtgaaggc actgagagcg ttccgcgtgc tccgtccact gcggctagtg tccggagtcc
     1921 caagtctcca ggtggtcctg aactccatca tcaaggccat ggtgcctctg ctgcacattg
     1981 cccttcttgt gctcttcgtc atcatcattt atgctattat cggcctggag ctcttcatgg
     2041 gaaagatgca caagacctgc tacaaccagg agggcataat agatgttccg gcagaagagg
     2101 atccttcccc ttgtgctttg gagacaggcc atgggcgaca gtgtcagaac gggaccgtgt
     2161 gcaaacccgg gtgggatggg cccaagcacg gcatcaccaa cttcgacaac ttcgccttcg
     2221 ccatgctgac ggtgttccag tgtatcacca tggagggctg gacagacgtg ctgtactgga
     2281 tgcaagacgc tatgggctat gagttgccct gggtgtattt tgtcagtctg gtcatctttg
     2341 gatccttttt cgttctaaat ctggttctcg gtgttttgag cggggagttt tccaaagaga
     2401 gggagaaagc caaagcccga ggagatttcc agaagcttcg agagaagcag caactagaag
     2461 aagatctcaa aggctacctg gactggatca cccaggcaga agacattgac cccgagaatg
     2521 aggacgaggg catggatgaa gacaagcctc gaaacatgag catgcccaca agtgagactg
     2581 agtctgtcaa cactgaaaac gtggctggag gtgacatcga gggagaaaac tgtggagcca
     2641 ggcttgccca tcggatctcc aaatccaaat tcagccgcta ctggcgcagg tggaatcgat
     2701 tctgcagaag aaaatgccgt gcagcagtta agtccaacgt cttctactgg ctcgtgatct
     2761 tcctggtgtt cctcaacacc ctcaccattg cctccgaaca ttacaaccag cctcactggc
     2821 tcacagaagt gcaagacaca gccaataaag ccctcctggc ccttttcact gcagaaatgc
     2881 tcctgaagat gtacagcctg ggtcttcagg cctattttgt gtccctcttc aaccgctttg
     2941 actgtttcat tgtgtgtggg ggcatcctgg agaccatcct ggtggagacg aagatcatgt
     3001 ctcccctggg catctctgtg ctgagatgtg tgcggttgct caggatcttc aagatcacca
     3061 ggtactggaa ttccttgagc aaccttgtgg catccttgct gaactcagtg cgctccattg
     3121 cctccctgct gctgctcctc ttcctcttca tcatcatctt ctccctcctg gggatgcagc
     3181 tctttggagg gaagttcaat ttcgatgaga tgcagacccg taggagcacg ttcgataact
     3241 tcccgcagtc tctcctcact gtgtttcaga tcctgaccgg ggaggactgg aattcggtga
     3301 tgtatgatgg gatcatggct tatggcggcc cctcttttcc agggatgtta gtctgtattt
     3361 acttcatcat cctcttcatc tgtggaaatt atatcctact gaatgtgttc ttggccattg
     3421 cggtggacaa cctggctgat gcggagagcc tgacctcagc ccaaaaggag gaggaagaag
     3481 agaaggagag gaagaagctg gccaggactg ccagcccaga aaagaaacag gaggtgatgg
     3541 agaagccagc cgtggaggag agcaaagagg agaaaattga actgaaatcc attacagccg
     3601 atggagaatc cccacccact accaagatca acatggatga cctccagccc agtgaaaacg
     3661 aggataagag tccccactcc aacccagaca ctgcagggga agaggatgaa gaggagccag
     3721 agatgcctgt ggggccacgc ccccggcccc tgtctgagct gcaccttaag gaaaaggcag
     3781 ttcccatgcc ggaagccagt gcatttttca tcttcagccc aaacaacagg ttccgcctgc
     3841 agtgccaccg tattgtcaat gacacgatct tcaccaacct catcctcttc ttcattctgc
     3901 tcagcagcat ctctctggct gctgaggacc ccgtccagca cacctccttc aggaaccata
     3961 tcctaggcaa tgcagactat gtcttcacta gtatctttac attagaaatt atccttaaga
     4021 tgactgctta cggggctttc ctgcacaagg gctctttctg ccgaaactac ttcaatatcc
     4081 tggacctgct ggtggttagc gtgtccctca tctcctttgg catccagtcc agcgcgatca
     4141 acgttgtgaa gattttacga gtgctgcgag tcctcagacc cctgagggcc atcaacaggg
     4201 ccaaggggct aaagcatgtg gttcagtgcg tgtttgtggc catccggacc atcgggaaca
     4261 tcgtaattgt caccactctg ctgcagttca tgttcgcctg cattggggtc cagctcttca
     4321 agggaaagct ctatacctgt tcggatagtt ctaaacagac ggaggcagaa tgcaagggta
     4381 actatatcac atacaaagat ggagaggtcg atcaccccat tatccagcct cgaagctggg
     4441 agaacagcaa gtttgacttt gacaatgttt tggcagccat gatggctctc ttcaccgtct
     4501 ccaccttcga agggtggcca gagctgctgt accgctccat tgactcccac acagaagaca
     4561 agggccccat ctacaactac cgtgtggaga tctccatctt cttcatcatc tatatcatca
     4621 tcattgcctt cttcatgatg aacatcttcg tgggtttcgt cattgtcacc ttccaggagc
     4681 agggggaaca agagtacaag aactgtgagc tggacaagaa ccagagacaa tgtgtggaat
     4741 atgccctcaa ggcccgaccc ttgcgaaggt acatccccaa gaaccagcac cagtacaaag
     4801 tgtggtacgt ggtcaactct acctacttcg agtatctgat gttcgttctc atcctgctca
     4861 acaccatctg cctggccatg cagcactatg gccagagctg cctcttcaaa atcgccatga
     4921 atatactcaa catgcttttc accggcctct tcacagtgga gatgatcctg aagctcattg
     4981 ccttcaaacc caagggttac tttagtgatc cctggaatgt ttttgacttc ctcatcgtca
     5041 ttgggagcat aattgatgtc attctcagtg agactaatcc agctgaacat acccaatgct
     5101 ctccctctat gagtgcagag gagaactccc gcatctccat caccttcttc cgcctcttcc
     5161 gggtcatgcg cctggtgaag ctgctgagcc gcggggaagg catccgaacc ctgctgtgga
     5221 ccttcatcaa gtccttccag gctctgccct atgtggctct tttgattgtg atgctgttct
     5281 ttatctatgc agtgattggg atgcaggtgt ttgggaagat tgccctgaat gacaccacag
     5341 agatcaatcg gaacaacaac ttccagacgt tcccccaggc tgtgttactg ctgttcaggt
     5401 gtgccaccgg agaggcctgg caggacatca tgctggcctg catgccaggc aagaagtgtg
     5461 ccccagagtc tgagcccagc aacagcacgg aaggggagac cccctgtggc agcagctttg
     5521 ctgtcttcta cttcatcagc ttctacatgc tctgtgcctt cctgatcatc aacctctttg
     5581 tagctgttat catggacaac tttgactacc tgactaggga ttggtctatc ctcggtcccc
     5641 atcacctgga tgaattcaag agaatctggg ccgagtatga ccctgaagcc aagggtcgga
     5701 tcaaacactt ggatgtggtg accctcctcc gtcgaattca gcccccactg ggttttggga
     5761 aattgtgtcc tcaccgtgtg gcctgcaaac gcctggtgtc catgaacatg cctctgaaca
     5821 gcgatggcac agtcatgttc aatgctaccc tgtttgccct cgtcaggaca gccctgagga
     5881 tcaaaacaga agggaaccta gagcaagcca atgaggagct tcgggccatc atcaagaaaa
     5941 tctggaagag gactagcatg aagctgttgg accaggtggt gccccctgca ggcgatgacg
     6001 aggtcacagt gggcaagttc tatgccacct tcctgatcca agagtacttc aggaaattca
     6061 agaagcgaaa agagcagggg ctggtgggca agccctcaca aaggaatgca ctgtccctcc
     6121 aggctggctt gcgcaccttg catgacattg ggcctgagat ccggcgggcc atctctgggg
     6181 atctgactgc tgaggaggag ttggacaagg ctatgaagga ggcggtgtct gctgcctccg
     6241 aagatgacat cttcaggagg gctggaggcc tgttcggcaa ccatgtcacc tactatcaga
     6301 gtgacagcag gggcaacttt cctcagacgt tcgccaccca gcgcccactg cacatcaaca
     6361 agacagggaa caaccaagct gacactgagt caccgtccca tgagaagctg gtggactcca
     6421 cgttcacccc cagcagctac tcatccacgg gctccaatgc caacatcaac aatgccaaca
     6481 acactgccct gggccgcttc ccccatcccg ctggctactc cagcacggtc agcactgtgg
     6541 agggccatgg gcctcccttg tcccctgctg tccgagtaca ggaggcagca tggaagctca
     6601 gctctaagag gtgccactcc cgagagagcc agggagccac ggtgaatcag gagatatttc
     6661 cagatgagac ccgcagcgta aggatgagtg aagaagccga gtactgcagt gagcccagcc
     6721 tgctctccac agatatgttc tcctaccagg aagatgaaca ccgacaactg acctgcccag
     6781 aggaggacaa gagggagatc cagccatctc caaagaggag tttccttcgc tctgcctctc
     6841 taggtcgaag ggcctccttc catctggaat gtctaaagcg acaaaaggat caagggggag
     6901 acatctctca gaagacagcc ttgcccttgc atctggttca tcatcaggca ttggcagtgg
     6961 caggcttgag ccccctcctg cagagaagcc attctcctac cacattcccc aggccgtgcc
     7021 ccacaccccc tgtcactcca ggcagccggg gcagacccct acggcccatc cctaccctac
     7081 ggctggaggg ggcagagtcc agcgagaaac tcaacagcag cttcccatcc atccactgca
     7141 gctcctggtc tgaggagacg acagcctgta gtgggagcag cagcatggcc cggagagccc
     7201 ggcccgtctc cctcaccgtg cccagccagg ctggagctcc agggagacag ttccatggca
     7261 gtgccagcag cctggtggaa gcggtcttga tttcagaagg actgggacag tttgctcaag
     7321 atcccaagtt catcgaggtc accacccagg agctggctga cgcctgcgac atgacaatag
     7381 aggagatgga gaacgccgca gacaacatcc tcagtggggg cgcccagcag agccccaacg
     7441 gcaccctctt accttttgtg aactgcaggg acccggggca ggacagggct gtggccccag
     7501 aggacgagag ctgcgcatat gccctggggc gaggccggag cgaggaggcg ctcgcggaca
     7561 gcaggtccta cgtcagcaac ctgtagtcct cagggctggc gagacgcggg tggttttttt
     7621 attcgtttca atgttcctaa tgggttcgtt tcagaagtgc ctcactgttc tcgtgacctg
     7681 gaggtaaccg gaacagcgtc ttcattcact gctgtcggga taagcctcag agctgggcgg
     7741 tgtacggagt cggcttttca ggggagaagg ccaaggccgt ggtgcggggg ctccagcacc
     7801 ttccgcggca gcaccgccca aaggacccca cccccacccc tgagcaaaag ggtgttttcc
     7861 ccttgcttgt ataaacagtc atttgcacat gttctgtctg agcctggccg tctctatgga
     7921 gcagggcccc agggatctat ggcaggaatg ggccagcgcc cccagtagga gccgggaggt
     7981 ggctgcgagg ttcccagcag tgcaggtctg gtccctatgg tcccttcagg gactctttcc
     8041 ctgcaaggag ctgagatgca ggtggcagga gccagtgcag atcacaccac ccgccctcag
     8101 ctagccaggc caggggggcg caggctgctg cctggtgctc ggggtttcat ggtttgaggg
     8161 ttcttgtcag catgttgcga ctttctgggg tttggtttct ttattactat ttgttgtgtt
     8221 ttcccacggg gaggggagga ataagagcgg ttacaactgc gcggcctcac ttcactgttt
     8281 ccacatttgc atttgcgtat ttaagtcgga tttggtttga ttgtattctt taaatggtgc
     8341 ggtccacccc caccgccacc cccacccccc actggagcaa gggttcaata tcaccagaga
     8401 aaggttttac ctgctctgtg tctgcccagt aacttgttcc aatttcctta agtaaaagca
     8461 acttttttct ttctttcgag tttggttgag catcacaatc agcaggctaa caggcagtta
     8521 gatcaggcgg tgtgcgcctg ggcgattgag ctgggctcct ttctgtgctg ggcatatgga
     8581 ctggttcaag agagaagaaa tatgggcatc tttgtgtcac acttgtgtcc atagtatgtg
     8641 cgtatgtgca cccacgtggt atgtgtgcgc cccaccccac ccctgcacaa aagcctgtag
     8701 aaccccgttt gggtttgact gcagggagtt ctaaatctgg ggctatttga aagcaagaac
     8761 aaaccactgt ctctgcttct gcttctgaaa cgagaatcgg taactgcatt tttctgtccc
     8821 acgagatatg caaaagcaat gcaataatat ccattttaaa atatggttgt gagttgtgtc
     8881 agcattaaaa ttctatttta aaaaaaaaac cacgaaattt aagggaaaaa ctcaagaaga
     8941 cattttgctt cgatatattc tgtgtaatgt tttattgcat tgataatgtt tctgttgaag
     9001 aaactgttat actt
//