From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens alpha actinin 3 (ACTN3) mRNA, complete cds.
Date: 21 Jul 92 10:05:16 GMT
Distribution: bionet
Checksum: 16893     7

LOCUS       HUMACTN3A    2858 bp ss-mRNA            PRI       21-JUL-1992
DEFINITION  Homo sapiens alpha actinin 3 (ACTN3) mRNA, complete cds.
ACCESSION   M86407
KEYWORDS    ACTN3 gene; skeletal muscle alpha-actinin.
SOURCE      Homo sapiens (library: lambda-gt10 of M.Koenig) fetus skeletal
            muscle cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Beggs,A.H., Byers,T.J., Knoll,J.H., Boyce,F.M., Bruns,G.A. and
            Kunkel,L.M.
  TITLE     Cloning and characterization of two human skeletal muscle
            alpha-actinin genes located on chromosomes one and eleven
  JOURNAL   J. Biol. Chem. 267, 9281-9288 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     5'UTR           1..18
                     /gene="ACTN3"
     CDS             19..2724
                     /function="'skeletal muscle specific'"
                     /product="alpha-actinin"
                     /gene="ACTN3"
                     /codon_start=1
                     /translation="MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWE
                     KQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFH
                     KIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSA
                     KEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGN
                     LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI
                     CKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYR
                     RLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGY
                     EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRR
                     HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRR
                     DALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHD
                     QFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL
                     VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQM
                     AGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIAR
                     TINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGE
                     VEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEE
                     LRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL"
     3'UTR           2725..2858
                     /gene="ACTN3"
     polyA_signal    2836..2841
                     /gene="ACTN3"
     polyA_site      2858
                     /gene="ACTN3"
BASE COUNT      667 a    815 c    896 g    480 t
ORIGIN      Chromosome 11q13-q14.
        1 gccaggagcc cgatcgagat gatgatggtt atgcagcccg agggtctggg ggccggggag
       61 gggcgctttg cgggcggcgg cgggggcggc gagtacatgg aacaggagga ggactgggac
      121 cgcgacctgc tgctggaccc ggcctgggag aagcagcagc ggaaaacctt cactgcctgg
      181 tgcaactcac acctgcgcaa ggcaggcacc cagatcgaga acatcgagga agatttccgc
      241 aatggcctca aactcatgct gctcctggag gtcatttcag gtgagaggct gcctaggcca
      301 gataaaggca agatgcgctt ccacaaaatc gccaacgtta acaaggccct ggacttcatt
      361 gccagcaagg gggttaaact ggtgtccatt ggtgctgaag agattgttga cgggaacctg
      421 aagatgaccc tgggcatgat ctggaccatc atccttcgct tcgccatcca ggacatctct
      481 gtggaagaaa cctcagccaa ggaaggcttg cttctgtggt gccagaggaa gacagcaccg
      541 taccgcaacg tcaacgtgca gaacttccac accagctgga aggatggcct ggccctctgt
      601 gccctcatcc accgacaccg ccctgacctc atcgactacg ccaaactgcg aaaggatgac
      661 cccatcggaa acctgaacac tgcctttgag gtggcagaga aatacctgga catccccaag
      721 atgttggatg cagaagacat tgtgaacacc ccaaagccgg atgagaaggc catcatgacc
      781 tatgtgtcct gcttctacca tgcctttgcc ggggctgagc aggcagagac agctgccaac
      841 aggatctgca aggtgctggc agtgaaccag gaaaacgaga agctgatgga ggagtatgag
      901 aagcttgcca gtgagctgct ggagtggatc cgccgcactg tcccatggct ggagaaccgt
      961 gtgggtgagc ccagcatgag tgccatgcag cgcaaactag aggactttcg ggactaccgg
     1021 cgtctgcaca agccgccccg cattcaggaa aagtgccagc tggagatcaa cttcaacaca
     1081 ctgcagacca agttgcggct cagccaccgg cctgccttca tgccctccga gggcaagctg
     1141 gtctcggaca tcgccaacgc ctggcggggg ctggagcagg tggaaaaggg ctatgaggac
     1201 tggctgctct cggagatccg gcgcctgcag cgactccagc acctggctga gaagttccgg
     1261 cagaaggcct ccctgcacga agcctggacc cggggaaagg aggagatgct gagccagcgc
     1321 gactacgatt cggctttgct acaggaggtg cgggcgttgc tgcggcgcca cgaggccttt
     1381 gagagcgacc tggcggcgca ccaggaccgc gtggagcaca ttgccgcgct ggcccaggag
     1441 ctcaatgagc tggactacca cgaggcagcc tcagtgaata gccgctgcca ggccatctgc
     1501 gatcagtggg acaacctggg caccctgacc cagaagaggc gggatgcgct agagcggatg
     1561 gagaagctcc tggagaccat tgaccagctg caactggagt ttgcccggcg ggccgcgccc
     1621 ttcaacaact ggctggatgg tgccgtggag gacctgcagg acgtgtggct ggtacactct
     1681 gtggaggaga cccagagcct gctgacagcg cacgatcagt tcaaggcaac actgcccgag
     1741 gctgaccgag agcgaggtgc catcatgggc atccagggtg agatccagaa gatctgccag
     1801 acgtatgggc tgcggccctg ctccaccaat ccctacatca ccctcagccc gcaggacatc
     1861 aacaccaagt gggatatggt ccgaaagctg gtgcccagcc gtgaccagac actgcaggag
     1921 gagctggcac ggcagcaggt aaacgagagg ctccggcgac agtttgcggc ccaggccaat
     1981 gccattggac cctggatcca ggcgaaggtg gaggaagtgg ggcggctggc agcagggcta
     2041 gctggctctc tggaggagca gatggctggg ctacggcagc aggagcagaa cattatcaac
     2101 tacaagacta acattgaccg gctggagggt gaccaccagc tgctgcagga gagcctggtg
     2161 ttcgacaata agcacaccgt ctacagcatg gagcacatcc gcgtgggctg ggagcagctg
     2221 ctcacctcca ttgcccgcac catcaatgaa gtggagaacc aggtactgac ccgagacgcc
     2281 aagggactga gccaggagca gctcaacgag ttccgagcat ccttcaacca ctttgacagg
     2341 aagcggaatg ggatgatgga gcctgatgac ttccgagctt gcctcatctc catgggctat
     2401 gacctggggg aagtggagtt tgctcgcatc atgaccatgg tggaccccaa cgcagctggg
     2461 gtggtgacct tccaggcctt catagacttc atgacccgag agacagccga gactgacacg
     2521 actgagcaag ttgtagcttc cttcaagatc ttggcaggag acaagaacta catcaccccc
     2581 gaggagctgc ggcgcgagct ccctgccaag caggccgagt actgcatccg ccgtatggtg
     2641 ccctacaagg gatccggggc cccggctgga gccctggact acgtggcctt ctccagtgcc
     2701 ctctatgggg agagcgacct ttgaccccaa ccactgaggt tctctatgca agatggagag
     2761 aggatgcacc ctgtggctga tcccatccgt ccctcggagc aagggcctaa gagaaaagcc
     2821 agccaagtgc ttctgaataa agatccctct ctgggtca
//