From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens gene for major histocompatibility complex encoded
Date: 3 Jan 93 22:06:45 GMT
Distribution: bionet
Checksum: 57250 8

LOCUS       HUMMHCPU10   4418 bp ds-DNA             PRI       21-DEC-1992
DEFINITION  H.sapiens gene for major histocompatibility complex encoded
            proteasome subunit LMP7
ACCESSION   Z14982
KEYWORDS    major histocompatibility complex; proteasome subunit.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4418)
  AUTHORS   Fruh,K., Yang,Y., Arnold,D., Chambers,J.C., Wu,L., Waters,J.B.,
            Spies,T. and Peterson,P.A.
  TITLE     Alternative exon usage and processing of the major
            histocompatibility complex-encoded proteasome subunits
  JOURNAL   J. Biol. Chem. 267, 22131-22140 (1992)
  STANDARD  full automatic
COMMENT     *source: haplotype=HLA DR 7; *source: cell_line=MANN; *source:
            clone=U10; *source: chromosome=6; *source: is_macronuclear=N;
            *source: is_proviral=N; *source: is_germline=N;
               From EMBL    entry HSMHCPU10;  dated 01-OCT-1992.
FEATURES             Location/Qualifiers
     mRNA            join(578..932,1185..1360,2122..2272,2431..2539,2948..3077,
                     3467..3680,4164..4418)
                     /gene="MHC-encoded proteasome subunit gene"
     prim_transcript 578..4418
                     /gene="MHC-encoded proteasome subunit gene"
     exon            578..932
                     /number=1
     intron          933..1184
                     /number=1
     exon            1185..1360
                     /number=2
     intron          1361..2121
                     /number=2
     exon            2122..2272
                     /number=3
     intron          2273..2430
                     /number=3
     exon            2431..2539
                     /number=4
     intron          2540..2947
                     /number=4
     exon            2948..3077
                     /number=5
     intron          3078..3466
                     /number=5
     exon            3467..3680
                     /number=6
     intron          3681..4163
                     /number=6
     repeat_unit     3711..3973
                     /rpt_family="ALU"
     exon            4164..4418
                     /number=7
BASE COUNT      996 a   1140 c   1140 g   1142 t
ORIGIN      
        1 actgtggttt cttatgtttc cggcacacca aacgggccac tgctttttgc agcgcacttt
       61 tccagctgcg gatgtcttcc tctttttatc aaccccaaag gttttacccc ctaactgcat
      121 caccctttcc ccttaagctt tttagtccct atgaggccct tccaattccc tatcccttag
      181 gccaccccca gatgttcaag accccaacca cagggcccat cagggcacta acggccgcaa
      241 gctcagagcc gtggcctctc cgaagtggca gatggggcgg gcccggccag accaagtgcc
      301 aggcgggaac agagggactg ggcgcgcctc acaaactcac cacctcgccc gctggtcctt
      361 cctggctcgc ctggctctga agctgcacct ggaggggaaa cctcagaaca gtaggcggga
      421 ttgcctagta aatatctccc attcagggag gcccaggtcg tgtgacgtcg acagttgctg
      481 ggtagatgag gccaacacag gttgcaagaa gaggcggggt ttagaggcgt gaaactccgc
      541 agtgctcagc caagcaggga gcaacgctag gaagggcggg cagaaagggc acgctcttgt
      601 gggtgactac aggttaggag accgttgaac ctggaggggc cctaggatgg accccgtgga
      661 aagattcaga gactgcgccc tctccctggc gccgccttcc cctacacgcg gcgggtatat
      721 tctgttgcag ttggcccagg acctgtttcc aagactctgc cccctcgcac ttccgtccct
      781 cctggttttg taaagtgatg ctcataggaa cccccacccc gcgtgacact actcccagct
      841 cctggctgac ttctagtctt ctggttgaag ctgcgccttt agatgacacg accctaccca
      901 cccctgtttc cagcggatgc ccgggcctgg aggtacctct tactgtaacc catcgccaag
      961 tgggcttttg aaggcgcctg ttcctttctc gctttcttcg gaagaccctt gacccatcat
     1021 tcccccgacc cccataacgg gagagcagag aagccggtcc ccagtgtgat ggtcctggtc
     1081 caggcactaa ctgtcctttt ctcggaaaag gcagggggat gtggaaaaga gtcttgttcc
     1141 ctccccttcg atctgtggct ttcgctttca cttcctcctc cgagagcgga cagatctctg
     1201 ggtgctggcg gtcatggcgc tactagatgt atgcggagcc ccccgagggc agcggccgga
     1261 atcggctctc ccggttgcgg gaagcgggcg tcgctcggac ccaggacact acagtttctc
     1321 tatgcgatct ccagagctcg ctttaccccg gggaatgcag gtcggggcag tagggaagcc
     1381 cctagggatg cagggaggcg ggcgctgagg agtggagggt cgcctgagag gaggaggcga
     1441 gagcgggagc gcggggtaca gggtcggggg tagccttcag tcccggagag cgccagaccc
     1501 aaagaagagg ccacatgggg atggggcctg agaggaggaa gtgcaagtta ggacaaagag
     1561 ttacaggtga ggtgggggct cccaaaggaa gacaagagaa ctttcctgcc cttgtccaca
     1621 cacaaatggt ggagccttct ttcatggggt tatcacatga tataggaggt gtgtggtgtc
     1681 ttgggaaacc tatgaaattt gcctgctggc ctcctctcag caactcactg ttgcgcgact
     1741 tagaacaagt cacttagtct aggtcccaag cccctcttct gtaaagtgag gatactgtta
     1801 ctaaacgtgt tttgtgaggg ttgaatgctt tatgcatgga agaaaccctt taagtcactc
     1861 tcaaaatttt ttagtaatgg taacatgtgc ttgctttcat ttctgttgtg ctggaaaatg
     1921 gaaaaggttg atactggcat gcctcttctt ttccttctcc caagccattt ccttctagag
     1981 attggttatt aactgtttca tttattgatg gttagatcat ttctgcatat ctcctcaccc
     2041 tcatactccc taaaaccttt tcctggagcc tcttactaca gaatttttca ttgcctttct
     2101 caacctcttt tctcttatca gcccacagaa ttcttccagt ccctgggtgg ggacggagaa
     2161 aggaacgttc agattgagat ggcccatggc accaccacgc tcgccttcaa gttccagcat
     2221 ggagtgattg cagcagtgga ttctcgggcc tcagctgggt cctacattag tgagtgtata
     2281 cgctccagca ggcagaatct ggggagctgg gctctccttt ccacaggagg ccaactctgc
     2341 aacaaagtgg aagtggatat tgatttagga cacactgggg gatctatggg gtcatccctt
     2401 ctctcccaaa gctccatctt cttccaggtg ccttacgggt gaacaaggtg attgagatta
     2461 acccttacct gcttggcacc atgtctggct gtgcagcaga ctgtcagtac tgggagcgcc
     2521 tgctggccaa ggaatgcagg taagcgaggc ctctcatctt cctttcttag cctagtggtt
     2581 aatccctgga tctctcagat cattgctcct tactcttgtc ctatgtggtc catcttagtg
     2641 ctaatagtat atttcacaaa acagcttttt ggtgataaga cccttctccc aaatctcagc
     2701 ctgtgctcca ctcataagcc agatagtacg tcaggtattt agcactgaca catccaccct
     2761 ggcgggacag tatgatttac taggctgcct ttgtatgttt cagatacgtt aaattccaaa
     2821 tctttctctg atctttagat cctacaaaat aattcctttc caatgcttat ctctttaatc
     2881 atttcctgcc ccatcaagtt ggaaagagct aacctctctt tcctcactcc accttgtcct
     2941 cacccaggct gtactatctg cgaaatggag aacgtatttc agtgtcggca gcctccaagc
     3001 tgctgtccaa catgatgtgc cagtaccggg gcatgggcct ctctatgggc agtatgatct
     3061 gtggctggga taagaaggtg ggtgctctcc attcttcatg ttcccccacc atgttcccta
     3121 tggatgacag atctgtttcc catcatatac tcctactccc tccctgacaa gatgcatggc
     3181 atatagagtg cttggttata gaactgtttc agtatatcca tggactattt attggcccag
     3241 atatgaatca ttgcatgtgt tttgtaagct tgtccctttt ggtaaacagt tgatttcaag
     3301 tttgtttttc ctttttcatt tctaaagttc gatgacttta ccaaagtggt ttcctaattc
     3361 caatgttctt gtggtaataa taattctttt gttcactttt tatgtctcat atttgaaccc
     3421 ccatgttacc aacatcttcc tctccaattt cagcctgaaa tctttcatct tatagggtcc
     3481 tggactctac tacgtggatg aacatgggac tcggctctca ggaaatatgt tctccacggg
     3541 tagtgggaac acttatgcct acggtgtcat ggacagtggc tatcggccta atcttagccc
     3601 tgaagaggcc tatgaccttg gccgcagggc tattgcttat gccactcaca gagacagcta
     3661 ttctggaggc gttgtcaata gtaagagacc aatgctccca ccaccatgcc tgggaggagt
     3721 cggcgggtgg tggggggggt gatttaagat tgagaaacca gcctggccaa catggcgaaa
     3781 ccccgtctct actaaaacta caaaaattag ccggacgtgg tgacgggtgc ctgtagtccc
     3841 agctacttgg gaggctgagg caggagaatc acttgaacct gggaggtgga gcttgcagtg
     3901 agccaagatg tcgccactgc attccagtct gggccacaga gtgagactcc ttctcacaag
     3961 aaaaaaaaga aaatgattga gagactcaaa ggagggagag tagtagggag gaaattttca
     4021 gagtcagaag aagggcatta aaggcccagt catatggttt taagcttgcg catgtgtctt
     4081 gttgctgcct tcaacataac atcagtgaca ggaacttgct gaggtgaaag gtgactccat
     4141 gttcttttct catttgtcca cagtgtacca catgaaggaa gatggttggg tgaaagtaga
     4201 aagtacagat gtcagtgacc tgctgcacca gtaccgggaa gccaatcaat aatggtggtg
     4261 gtggcagctg ggcaggtctc ctctgggagg tcttggccga ctcagggacc taagccacgt
     4321 taagtccaag gagaagaaga ggcctagcct gagccaaaga gagagtacgg gctcagcagc
     4381 cagaggaggc cggtgaagtg catcttctgc gtgttctc
//