From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human erythroid alpha-spectrin (SPTA1) mRNA, complete cds.
Date: 24 Jul 92 10:07:28 GMT
Distribution: bionet
Checksum: 13060    15

LOCUS       HUMSPTA01    8001 bp ss-mRNA            PRI       24-JUL-1992
DEFINITION  Human erythroid alpha-spectrin (SPTA1) mRNA, complete cds.
ACCESSION   M61877 J05244
KEYWORDS    alpha-spectrin; erythroid alpha-spectrin; spectrin.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 8001)
  AUTHORS   Sahr,K.E., Laurila,P., Kotula,L., Scarpa,A.L., Coupal,E.,
            Leto,T.L., Linnenbach,A.J., Winkelmann,J.C., Speicher,D.W.,
            Marchesi,V.T., Curtis,P.J. and Forget,B.G.
  TITLE     The complete cDNA and polypeptide sequences of human erythroid
            alpha-spectrin
  JOURNAL   J. Biol. Chem. 265, 4434-4443 (1990)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Hentati,A., Hu,P., Asgharzadeh,S. and Siddique,T.
  TITLE     Dinucleotide repeat polymorphism at the human erythroid alpha
            spectrin (SPTA1) locus
  JOURNAL   Hum. Mol. Genet. 1, 218-218 (1992)
  STANDARD  full staff_review
COMMENT     Draft entry and computer-readable sequence for [1] kindly submitted
            by B.G.Forget, 26-JAN-1990.
            From EMBL    entry HSSPTA01;  dated 16-FEB-1991.
FEATURES             Location/Qualifiers
     CDS             187..7476
                     /product="erythroid alpha spectrin"
                     /gene="SPTA1"
                     /codon_start=1
                     /translation="MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAE
                     RGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQ
                     TKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKF
                     QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVN
                     QYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEA
                     IQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH
                     PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAA
                     INADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREK
                     MEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL
                     GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDA
                     LREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ
                     VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQ
                     LHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ
                     DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI
                     CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG
                     NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETW
                     IREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP
                     VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVY
                     VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA
                     YEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF
                     EGLLTPEGAQIRQELNARWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ
                     ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQR
                     QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED
                     LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERD
                     DLEKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDDKSSLDSLEALMKKR
                     DDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERT
                     KLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRS
                     EQVHGVINLGNSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQR
                     FNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTL
                     AEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES
                     WIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV
                     GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAV
                     RGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLHEESQNKEISS
                     KIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGAD
                     LGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRW
                     EQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSL
                     NEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKH
                     LSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGT
                     LESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG
                     LRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYL
                     PMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALA
                     EGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRVEAISLAMTTLASPIPTLATNKQL
                     LVDRRKS"
BASE COUNT     2393 a   1619 c   2173 g   1816 t
ORIGIN
        1 tgtcgattgt gtatggctga tgggattcta ggaccaagca agaggttttt tttttttccc
       61 ccacatactt aacgtttcta tatttctatt tgaattcgac tggacagttc catttgaatt
      121 atttctctct ctctctctct ctctctgaca cattttatct tgccaggttc taaaccttta
      181 ggaaaaatgg agcaatttcc aaaggaaacc gttgtggaga gcagtgggcc aaaggttttg
      241 gaaacagcag aagagatcca ggagaggcgt caggaagtgt tgactcggta tcaaagtttc
      301 aaggagcggg ttgctgagag gggtcagaag cttgaggatt cctatcactt acaagttttc
      361 aagcgagatg cagatgatct ggggaagtgg atcatggaga aagtcaatat cttaaccgat
      421 aagagctatg aagacccaac taatatacag gggaaatatc agaagcatca atcccttgaa
      481 gcagaggtgc aaacgaaatc aagactcatg tctgaactgg aaaaaacaag ggaagaacga
      541 tttaccatgg gtcattctgc ccacgaagaa acgaaggccc atatagagga gctacgccac
      601 ctgtgggacc tgctgttaga gctgaccctg gagaagggtg accagttgct gcgggccctg
      661 aagttccagc agtatgtaca ggagtgtgct gacatcttag agtggattgg agacaaggag
      721 gctatagcga catcagtgga gctaggtgaa gactgggagc gcaccgaagt tctgcataag
      781 aaatttgaag acttccaagt ggagctggta gctaaagaag ggagagttgt tgaagtgaac
      841 caatatgcca atgagtgtgc cgaggaaaac catcctgacc tacccttaat tcagtctaag
      901 caaaatgagg tgaatgctgc ctgggagcgc cttcgtggtt tggctctcca gagacagaaa
      961 gctctgtcca atgctgcaaa cttacaacga ttcaaaaggg atgtgactga agccatccag
     1021 tggatcaagg agaaggaacc tgtactcacc tctgaggact atggcaaaga ccttgttgcc
     1081 tctgaaggac tgtttcacag ccacaaggga cttgagagaa atcttgcagt catgagtgac
     1141 aaggtgaagg agttatgtgc taaagcagag aagctgacac tttcccatcc ttcagatgca
     1201 cctcagatcc aggagatgaa agaagatctg gtctccagct gggagcatat tcgtgccctg
     1261 gccaccagca gatatgaaaa actgcaggct acttattggt accatcgatt ttcatctgac
     1321 tttgatgaac tctcaggctg gatgaacgag aagactgctg cgatcaatgc tgatgagctg
     1381 ccaacagatg tggctggtgg agaagttctg ctggacaggc atcagcagca taagcatgag
     1441 attgactctt acgatgaccg atttcaatct gctgatgaga ctggtcaaga cctcgtgaat
     1501 gccaatcatg aagcctctga tgaagttcgg gaaaagatgg aaatacttga caacaactgg
     1561 actgccctgc tggaactgtg ggacgagcgt catcgtcagt atgagcagtg cttggacttt
     1621 catctcttct acagagacag tgagcaagtg gacagttgga tgagtagaca agaggccttc
     1681 ctggaaaacg aggatctggg aaactcactg ggcagtgcag aagcccttct tcagaagcat
     1741 gaagactttg aggaagcctt tactgcccag gaagagaaga tcataactgt agacaagact
     1801 gcaaccaaat tgattggtga tgaccattat gattcagaga acatcaaggc tatccgtgac
     1861 ggcctgttag cccggcggga tgccctacgt gaaaaggctg ccactagacg tagattgctg
     1921 aaggagtcat tgcttctgca aaaactgtat gaggactcag atgacctaaa gaactggatc
     1981 aacaagaaga aaaagttggc agatgatgaa gattacaagg acatacagaa cttgaagagc
     2041 agggttcaaa agcagcaagt ctttgaaaag gagttggcag ttaataagac ccagctggaa
     2101 aacatacaga aaactggcca agagatgatt gagggtggtc actatgcctc tgacaatgtg
     2161 accactcgtc tgagtgaagt tgccagcctc tgggaggagt tgctggaggc tacaaaacag
     2221 aaagggaccc agttgcatga ggccaaccag cagctgcaat ttgaaaataa tgcagaagat
     2281 ttgcagcgct ggctggagga tgttgagtgg caagtcacct ctgaggatta tgggaaaggc
     2341 ctggccgagg tacagaatcg actcaggaaa cacggcctcc tggagtcggc tgtggctgct
     2401 cgtcaggatc aggtggatat ccttacagac ctggctgcat attttgaaga aataggccat
     2461 cctgattcta aggatataag ggcaaggcaa gagtccttgg tatgccgatt tgaagctctg
     2521 aaagagccac tggccacccg aaagaagaag ctcttagacc ttctccatct gcagctgatt
     2581 tgtagagaca cagaggatga ggaggcctgg atccaagaga ctgaaccctc agctacttcc
     2641 acctaccttg gaaaggacct gattgcttcc aaaaagcttc tgaataggca tagagtcatc
     2701 ctggagaaca ttgccagcca tgaaccacgc attcaagaga taacagaaag gggaaacaaa
     2761 atggtagagg aaggacactt tgctgcagaa gatgtggcct ctagggtcaa gagtttgaac
     2821 cagaatatgg agtctctccg tgctcgagct gctaggcgac aaaatgatct tgaagccaat
     2881 gtccagttcc agcagtacct ggctgacctg catgaagcag aaacatggat cagagagaag
     2941 gaacctattg tagataatac taactatggt gctgatgaag aagcagctgg ggctcttcta
     3001 aagaagcatg aggcctttct attagatctc aattcatttg gagacagtat gaaagctctg
     3061 cggaatcagg caaacgcctg ccagcaacaa caggctgcac cagtggaggg agttgctgga
     3121 gaacaaaggg tcatggcttt atatgacttc caggcccgca gcccccgaga agtcaccatg
     3181 aagaaaggtg atgtcttaac gctgctcagt tccatcaata aggactggtg gaaggtggaa
     3241 gctgctgatc atcagggcat tgtcccagct gtctatgtca gaagactggc ccacgatgag
     3301 ttcccgatgc tcccacagcg gcgacgagaa gagccaggaa acatcaccca gcgccaggag
     3361 cagattgaga accaataccg ctccctcttg gatcgggcag aagaacgcag acgtcgtcta
     3421 ttgcaacgtt ataatgaatt tttattggcc tatgaggcag gagacatgct ggaatggatt
     3481 caagagaaaa aggcagaaaa cactggagtg gaactagatg atgtttggga gctgcagaaa
     3541 aagtttgatg agttccaaaa ggatttgaat accaatgagc ctcggctaag ggatatcaac
     3601 aaggtagctg atgatctact atttgaagga cttctaacac cagaaggagc tcaaatccgg
     3661 caggaattga atgcccgctg gggttctttg cagaggcttg cagatgaaca gcggcagctg
     3721 ctgggcagtg cccatgctgt tgaagtgttt cacagagaag cagatgacac gaaggagcag
     3781 attgagaaga aatgccaggc cctcagtgct gcagaccctg gctcagatct gttcagtgtt
     3841 caggctcttc agcgacggca tgagggcttt gaaagggacc tcgtacccct gggagataag
     3901 gtgaccatac tgggggagac agcagagcgg ctcagtgagt cccatccaga tgccactgag
     3961 gacctgcaga gacagaaaat ggagctgaat gaggcctggg aagacctgca ggggcgtaca
     4021 aaggatcgta aggagagcct aaatgaggcc cagaaattct acctgttcct cagcaaggcc
     4081 agggatctgc agaactggat cagtagcatt ggtggcatgg tatcatcaca ggagctggcc
     4141 gaagacttaa ctggcataga gatcttgctg gagagacatc aggagcaccg tgctgacatg
     4201 gaggcagagg ctcccacctt ccaggcctta gaggacttca gtgcagaact tatcgacagt
     4261 gggcaccatg ctagccctga aattgaaaaa aagcttcaag ctgtcaagct agagagagat
     4321 gatttggaga aggcttggga aaaacgcaag aagatcctag accagtgcct ggagttgcag
     4381 atgttccagg ggaactgtga tcaagttgag agccggatgg tggcacgtga gaattccctg
     4441 aggtcagatg acaaaagttc cttagacagt ctggaggctt tgatgaagaa acgggacgat
     4501 ttggacaaag caatcactgc ccaggaaggg aagatcactg acctagaaca ttttgctgag
     4561 agcctcattg ctgatgaaca ctatgccaaa gaagagattg ctacgcggct ccaacgtgta
     4621 ctagacaggt ggaaggctct caaagcacaa ctgattgatg agcggacaaa gcttggagac
     4681 tatgccaacc taaaacaatt ctaccgagac cttgaggagc tggaagaatg gatcagtgag
     4741 atgctgccca cagcctgtga tgaatcctac aaagacgcca ctaacattca gaggaaatac
     4801 ctgaaacacc agacctttgc acatgaagtc gatggccgat ctgagcaggt gcatggcgtc
     4861 atcaacctgg ggaactccct gattgagcgt agttgtgatg gcaatgaaga ggccatgaag
     4921 gagcaactgg aacagctgaa ggaacattgg gatcatctgc ttgagagaac aaatgacaaa
     4981 gggaagaagc tcaatgaggc cagtcgtcaa cagaggttca acacaagcat ccgggacttt
     5041 gagttctggc tctcagaggc agagacattg ctggccatga aagatcaggc cagggacttg
     5101 gcttcagcag gaaacctact caagaagcat cagctattgg agagagagat gttggctcga
     5161 gaggatgcac tcaaggacct gaatacattg gctgaagatt tgctctccag cgggactttc
     5221 aacgttgatc agattgtgaa gaaaaaagat aatgtcaaca agcgtttcct gaatgtccaa
     5281 gaattggcag ctgcacacca cgaaaaattg aaagaggcct atgccttgtt ccagttcttc
     5341 caggatctag atgatgagga atcctggata gaggagaagt tgatacgagt gagctcccag
     5401 gactatggga gagatcttca gggggttcag aacttgctga agaagcacaa acgcctagag
     5461 ggggagctgg tggcccatga gcctgccatc cagaatgtgc tggatatggc agagaagctg
     5521 aaagacaagg ctgctgtggg gcaagaggag atccagttgc ggctggctca gtttgttgaa
     5581 cactgggaga agctcaaaga gttggccaag gcccgaggac ttaagttgga agaatcccta
     5641 gaatacttgc aattcatgca gaatgctgag gaagaggaag cttggatcaa tgaaaagaat
     5701 gctttggctg tccgaggaga ttgtggagat acattagctg ctactcagag cttgctaatg
     5761 aagcatgaag ctttggaaaa tgactttgct gtccatgaga cccgagtaca aaatgtgtgt
     5821 gcacaaggag aagacatcct aaataaggtg ttgcatgagg aaagtcagaa caaagagatt
     5881 tcttccaaga tagaggctct gaatgaaaag accccttctc tggctaaggc aatagctgct
     5941 tggaagttgc aattggaaga cgattatgcc tttcaggaat tcaactggaa ggctgatgtg
     6001 gtagaggctt ggatagctga taaggaaaca agcctaaaga ccaatggcaa tggtgcagac
     6061 cttggtgact tcctcactct tctggcaaaa caggacactc tggatgccag tctgcagagt
     6121 ttccagcaag agagacttcc cgagatcact gacctgaagg acaaactgat ttctgctcaa
     6181 cacaaccagt ctaaagccat tgaagagcgt tatgccgctc tgctgaagcg ctgggaacag
     6241 ttgctggaag cctcggcagt ccacagacag aaattgctgg agaaacagct gcctctacag
     6301 aaggctgagg acctgttcgt ggaatttgca cataaggctt cagctttgaa caactggtgt
     6361 gaaaagatgg aagaaaactt gtcagagcct gtgcactgtg tctccctgaa tgaaattcgg
     6421 cagctgcaga aagaccatga ggacttcttg gcctccctgg ctagggctca agcagacttt
     6481 aaatgtttgc tggagctaga ccagcagatt aaggccttag gtgtgccttc cagcccttat
     6541 acctggttaa cagtggaggt gctggaaagg acctggaagc acctatctga catcattgag
     6601 gaacgggagc aggagctgca aaaggaagag gcaagacagg tcaagaactt tgagatgtgt
     6661 caggagtttg aacagaatgc cagtaccttc cttcaatgga tcctggaaac cagggcttac
     6721 tttctggatg gatcattgct caaagaaaca ggaactctgg aatctcagct ggaagcaaat
     6781 aaaagaaaac agaaggagat ccaggcgatg aagcgtcaac taaccaagat tgtggacctg
     6841 ggggacaact tggaagacgc tctgatcctt gatatcaaat acagcaccat tggattggct
     6901 cagcagtggg accagctcta ccagcttggg ttgcggatgc aacacaacct ggagcaacag
     6961 atccaggcca aggacatcaa aggtgtgagt gaagagactc taaaggaatt tagcacaatc
     7021 tataaacact ttgatgagaa tttgacaggg cgcctgactc acaaagagtt ccggtcctgc
     7081 ctgagaggac tcaattacta cttgcccatg gtggaggagg atgaacatga gcccaagttt
     7141 gagaagttcc tggatgctgt ggatccaggg aggaagggct atgtctcact ggaggactat
     7201 actgctttcc tgattgacaa ggagtcagaa aacatcaagt ccagtgatga aatagagaat
     7261 gccttccaag ccctggcaga gggcaagtca tatattacca aagaagacat gaagcaggcc
     7321 cttaccccag agcaagtgtc attctgtgcc acacatatgc agcaatatat ggacccacgg
     7381 gtcgaagcca tctctctggc tatgactacg ttggcttcac caattcctac tttggcaact
     7441 aataagcagc tcctcgtgga tcgtagaaaa tcttagtgtc gtgggaaatt tactgggggg
     7501 caaagagtac aggcaaatgt ggaagataaa gatggcctcg tgtgtgtgtg tgtgtgtgtg
     7561 tgtgtgtgtg tgtgcttgtg tttgtgtgca tattacattt attgtaggat ctttaaaaaa
     7621 tctcaagggt gggagataga aaggttaata gagttggagg agtggaagct attttgtatg
     7681 caactagtca ctgctgaggg gtgtcaaagt ttctattttt atttgttctg ttttgcacgt
     7741 ctttatcatt ttcctttatt ccgattatag aataaagtaa ttctttttaa aaatattttt
     7801 tggggcaaag ttaagtaaaa tgttgagctt ctatatttct gggaactgta ctcatataag
     7861 agtgggcagc taattttact gtaaagaagg gccatggtat agtagataaa taaaatccaa
     7921 ggcaattttc aaacaatttt tttaaacttt ggaatgtgtt taaatttaaa tttgaaaata
     7981 aagatatttg attttctggg g
//