From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human cAMP-dpendent protein kinase (AKAP 79) mRNA, complete cds.
Date: 28 Jul 92 10:03:00 GMT
Distribution: bionet
Checksum: 59492     7

LOCUS       HUMAKAP79A   2618 bp ss-mRNA            PRI       28-JUL-1992
DEFINITION  Human cAMP-dpendent protein kinase (AKAP 79) mRNA, complete cds.
ACCESSION   M90359
KEYWORDS    anchoring protein; cAMP dependent; protein kinase.
SOURCE      Homo sapiens thyroid gland cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Carr,D.W., Stofko-Hahn,R.E., Fraser,I.D., Bishop,S.M., Acott,T.S.,
            Brennan,R.G. and Scott,J.D.
  TITLE     Interaction of the regulatory subunit (RII) of cAMP-dependent
            protein kinase with RII-anchoring proteins occurs through an
            amphipathic helix binding motif
  JOURNAL   J. Biol. Chem. 266, 14188-14192 (1991)
  STANDARD  full staff_entry
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Carr,D.W., Stofko-Hahn,R.E., Fraser,I.D., Cone,R.D. and Scott,J.D.
  TITLE     Localization of the cAMP-dependent protein kinase to the post
            synaptic density by A-Kinase Anchoring Proteins: Characterization
            of AKAP 79
  JOURNAL   Unpublished (1992)
  STANDARD  full staff_entry
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Hirsch,A.H., Glantz,S.B., Li,Y., You,Y. and Rubin,C.S.
  TITLE     Cloning and expression of an intron-less gene for AKAP 75, an
            anchor protein for the regulatory subunit of cAMP-dependent protein
            kinase IIb
  JOURNAL   J. Biol. Chem. 267, 2131-2134 (1992)
  STANDARD  full staff_entry
REFERENCE   4  (sites)
  AUTHORS   Carr,D.W., Hausken,Z.E., Fraser,I.D., Stofko-Hahn,R.E. and
            Scott,J.D.
  TITLE     Association of the type II cAMP-dependent protein kinase with a
            human thyroid RII-anchoring protein: Cloning and characterization
            of the RII-binding domain
  JOURNAL   J. Biol. Chem. 267, 13376-13382 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     5'UTR           1..1297
                     /gene="AKAP 79"
     CDS             1298..2581
                     /product="protein kinase"
                     /gene="AKAP 79"
                     /codon_start=1
                     /translation="METTISEIHVENKDEKRSAEGSPGAERQKEKASMLCFKRRKKAA
                     KALKPKAGSEAADVARKCPQEAGASDQPEPTRGAWASLKRLVTRRKRSESSKQQKPLE
                     GEMQPAINAEDADLSKKKAKSRLKIPCIKFPRGPKRSNHSKIIEDSDCSIKVQEEAEI
                     LDIQTQTPLNDQATKAKSTQDLSEGISQKDGDEVCESNVSNSITSGEKVISVELGLDN
                     GHSAIQTGTLILEEIETIKEKQDVQPQQASPLETSETDHQQPVLSDVPPLPAIPDQQI
                     VEEASNSTLESAPNGKDYESTEIVAEETKPKDTELSQESDFKENGITEEKSKSEESKR
                     MEPIAIIITDTEISEFDVTKSKNVPKQFLISAENEQVGVFANDNGFEDRTSEQYETLL
                     IETASSLVKNAIQLSIEQLVNEMASDDNKINNLLQ"
     3'UTR           2582..2618
                     /gene="AKAP 79"
BASE COUNT      950 a    476 c    504 g    688 t
ORIGIN
        1 gaattccttt ttttttacta atgaaacact gcagattagt atccccaaac aattcatttt
       61 ctgacgaaac tcttaaagcc cagtttcaga acataagctt taagcaacaa gcaatcttgt
      121 gttaatctga gctctgttac agctctgccg taatctcagc caaattgctt catctgtacg
      181 tggtgatacc accatctttg taatattgtg gtgaggatta gagatgtatg taaaagtgca
      241 tgcactgcct aatacccaag aattgctcaa taaatgtcag ctattactac tcttactgac
      301 ttccaactat gtgcagatta tggtggaaac atgtgataca gcagatacag tacttaaatg
      361 aaaatgtcaa aattgtacaa ctaatttaag agtgggaaat gacagtaatg ctaaattttc
      421 ctaagaatat gtatgaaaaa tagcacttcc ttgatggaac atacattttt agaacagaaa
      481 ccttatgtta taatggtaaa actagagagt caaagtctct agttctaact ctggctatga
      541 ccttatctag ttgcatggct tttgacaaga caactgctcc cctctggagt tcagttttgt
      601 catctggctg gatttgagta atctcaaata atctctaaag tcctttgcag ctttaaatta
      661 tctattgagt gtgataaaga ttacatcagc ttgcttttca tcctgcactt catttttggt
      721 tcttgttgtt tgcttaactt gcactttaga gtcataagca attcacacag acaacacaac
      781 taaagaactg ataatatcag acttgcaggg taatccaaaa tgaagtttca acaaggagga
      841 taaaacaaaa tagaatcaca ctgaactctt taatagggcc aaagtaaacc ccaatgttta
      901 ttctccagtc atttcattaa gttattatat ggaaaatatg cctggtagaa tcttatacat
      961 tcactgaaat agtctccaca gaaaataata ggctcatagt gaaataaaat accactttct
     1021 tttctctcat caggttgatc tttaaataaa gcaaaaattt atccaaagaa gggctttcat
     1081 caagaaatta aagagagaaa ttacaagcca tagagaaact gggcatttct atactagaga
     1141 aaccacctaa aacaactgta tggagtaaga tgaaaggtac tgaatatgcc tggaagaaat
     1201 tttacctagt gtgacatttt tgctcatctt tttgtcacaa aaggctgcta aggaagagag
     1261 aatacagttt tctagagaat aagagtgcag tgtaaaaatg gaaaccacaa tttcagaaat
     1321 tcatgtagaa aacaaggatg agaagagatc agcagaaggt agtcctgggg ctgaaaggca
     1381 gaaggaaaag gcatccatgc tttgcttcaa gagaagaaag aaagcagcca aagcactgaa
     1441 gcccaaagct ggctctgaag ctgctgatgt ggcaaggaag tgtccacaag aagcaggagc
     1501 ttctgatcag ccagagccca cacggggggc ctgggcctca ctcaaacgtc ttgtaacacg
     1561 caggaaaagg tcagagtctt caaagcagca aaagccattg gagggtgaaa tgcaacctgc
     1621 aataaatgct gaggatgctg atctttctaa gaaaaaggca aaatctagac ttaagattcc
     1681 ctgcataaaa ttcccaagag ggccaaaaag gagtaatcat tccaaaatta tagaagactc
     1741 agactgcagc atcaaagtcc aggaagaagc tgaaattttg gatatacaaa cacagacccc
     1801 attgaatgat caggcaacaa aggctaagtc aacccaggat ctaagtgaag gcatctcaca
     1861 gaaagatggt gatgaggtct gtgaatcaaa tgtgagcaat agcataactt ctggagagaa
     1921 agtgatttca gtagaacttg gattagataa tgggcattct gctattcaaa cgggaactct
     1981 aatccttgaa gaaattgaaa cgatcaagga aaaacaagat gttcaacccc agcaagcaag
     2041 cccacttgaa acttcagaaa cagaccatca gcagccagta ctttctgatg ttcctccttt
     2101 acctgcaatt ccagatcaac aaattgtgga agaagccagt aacagtaccc tagaaagtgc
     2161 accaaatgga aaagactatg aaagtacaga gattgtagct gaagaaacta agccaaaaga
     2221 tactgaattg agccaagaat cagattttaa agaaaatggg atcactgaag agaaatccaa
     2281 atcagaagaa agcaaaagaa tggagccaat tgctattatt attacagaca ctgaaatcag
     2341 tgaatttgat gttacaaaat ctaaaaatgt ccctaagcaa ttcttaattt cagctgaaaa
     2401 tgagcaagta ggggtttttg ctaatgataa tggttttgag gatagaactt cagaacaata
     2461 tgaaacactc ttaattgaaa cagcctcttc tctagtcaag aatgctattc agttgtcaat
     2521 agaacagctg gttaatgaaa tggcctctga tgataataaa ataaacaatc ttctacagtg
     2581 acttactctc cagagtcacg gcagaaaaaa aggaattc
//