From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rattus norvegicus calcium transporting ATPase mRNA, complete cds.
Date: 27 Aug 92 10:00:45 GMT
Distribution: bionet
Checksum: 10662     8

LOCUS       RATCTA       3457 bp ss-mRNA            ROD       27-AUG-1992
DEFINITION  Rattus norvegicus calcium transporting ATPase mRNA, complete cds.
ACCESSION   M99223
KEYWORDS    calcium transporting ATPase.
SOURCE      Rattus norvegicus (strain CD) male adult skeletal muscle cDNA to
            mRNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 3457)
  AUTHORS   Wu,K.-D. and Lytton,J.
  TITLE     Molecular cloning and quantification of mRNA and protein encoding
            Ca2+-ATPase isoforms in rat muscles
  JOURNAL   Am. J. Physiol. (1992) In press
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     5'UTR           1..165
     CDS             166..3150
                     /product="calcium transporting ATPase"
                     /gene="SERCA1a"
                     /codon_start=1
                     /translation="MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAE
                     EGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVP
                     ADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINI
                     GHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICSLNEFSITGSTYAPE
                     GEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE
                     KMNVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAV
                     GNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALAT
                     RDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMI
                     TGDNKGTAIAICRRIGIFSENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPS
                     HKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNF
                     STIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWF
                     LYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNALN
                     SLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLK
                     ISLPVIGLDELLKFIARNYLEG"
     exon            3146..3187
                     /label=adult specific
     3'UTR           3151..3457
     CDS             3187..3213
                     /note="neonatal isoform C-terminal"
                     /product="calcium transporting ATPase"
                     /gene="SERCA1b"
                     /codon_start=1
                     /translation="DPEDERRK"
                     /partial
     polyA_signal    3308..3313
     polyA_signal    3439..3444
                     /note="this signal used in all clones isolated"
                     /evidence=EXPERIMENTAL
BASE COUNT      778 a    935 c    951 g    793 t
ORIGIN
        1 tggggtcaga acttcgtgga aaggagaaga atctgggggg ggcaagcaag aaaaaggaag
       61 gagcccaggt taacaggcag gtggatacac tgaagaagtc cccccacaag tgagaggccc
      121 ctaagaagga atacatcacc ccctggcccc caagaaggga gcagaatgga ggccgcacac
      181 tccaagtcca cagaggaatg tttgtcctat tttggggtga gcgagaccac aggccttacc
      241 ccagaccaag ttaagcggca tctggaaaaa tacggcccca atgagctccc tgctgaggaa
      301 ggcaagtctc tgtgggagtt ggtggtagag cagttcgaag acctgctggt gcggattctc
      361 ctcctggctg cctgcatttc ctttgtgctg gcctggtttg aggaaggtga ggaaactgtc
      421 actgcctttg tggagccttt tgtcattctc ttgatcctca ttgccaacgc cattgtgggg
      481 gtttggcagg aacggaatgc agagaatgcc atcgaggcgc tgaaggaata tgaacccgag
      541 atggggaagg tctatcgggc tgaccgaaag tcagtgcaaa ggatcaaggc tcgggacatc
      601 gtccctgggg acattgtgga ggtggctgtt ggggacaaag tccctgcaga catccgaatc
      661 ctctccatca aatccaccac cctccgggtc gaccagtcca tcctgacagg agagtctgta
      721 tctgtcatca agcacacaga ccctgtccct gatccccgag ctgtcaacca ggacaagaag
      781 aacatgctct tctcgggtac caacattgca gccggcaagg ccgtaggcat cgtggccacc
      841 actggtgtga gtactgagat tggcaagatc cgagaccaaa tggctgccac tgagcaggac
      901 aagaccccgc ttcagcagaa gcttgatgag tttggggaac agctgtccaa ggtcatctct
      961 ctcatctgtg tggctgtctg gcttatcaac attggtcact tcaacgaccc tgtccatggg
     1021 ggctcctggt tccggggggc catttactac ttcaagattg ctgtagcctt ggctgtggca
     1081 gccatcccag aagggcttcc tgctgtcatc accacctgct tggccttggg tacccgccgg
     1141 atggcaaaga agaacgccat cgtgaggagt ttgccctctg tggagaccct gggctgtacc
     1201 tctgtcatct gttctgacaa aacagggacc ctcaccacca accagatgtc agtttgcaag
     1261 atgttcatca ttgacaaagt ggatggggat atctgctcac tgaacgagtt ctccatcact
     1321 ggctctactt atgctcctga gggagaagtt ttgaagaatg ataagccagt ccgagcaggg
     1381 cagtatgacg ggctggtgga acttgctacc atctgtgccc tctgcaatga ctcctccttg
     1441 gactttaatg agaccaaagg tgtctatgag aaggtgggcg aggccaccga gacagccctc
     1501 accaccttgg tggagaagat gaatgtgttc aacacggaag tgagaagcct ctccaaagtg
     1561 gagcgggcta atgcctgcaa ctcggtgatc cgccaactaa tgaagaagga attcaccctg
     1621 gaattttccc gagacaggaa gtctatgtct gtctactgct ccccagccaa gtcttcacgg
     1681 gctgctgtag gcaacaagat gtttgtcaag ggtgcccctg agggcgtcat tgaccgctgt
     1741 aactatgtgc gtgttggcac aacccgtgtg ccactgacag gccctgtgaa ggagaagatc
     1801 atgtcggtga tcaaggagtg gggtactggt cgggataccc tacggtgcct ggcactggcc
     1861 acccgggaca caccccccaa acgggaggaa atggttctgg atgactcagc caagttcatg
     1921 gagtatgaga tggacctgac gtttgttggt gtggtgggca tgttggatcc accccgtaag
     1981 gaggtcacag gctctatcca gctgtgtcgt gatgccggga tccgagtgat catgatcact
     2041 ggggacaaca agggtaccgc catcgccatc tgccgacgaa ttggcatctt ttcggagaat
     2101 gaggaagtgg cagaccgtgc ctacactggc cgtgagtttg atgatctgcc cctggctgag
     2161 cagcgggaag cctgcagacg cgcctgctgc ttcgctcgtg tggagccctc acataagtcc
     2221 aagattgtgg agtacctgca gtcctatgat gagatcacag ccatgacagg ggatggtgtc
     2281 aatgatgccc ctgctctgaa gaaggcggag attggcattg ccatgggatc tggtactgct
     2341 gtggctaaga ctgcctccga gatggtactg gctgatgata acttctccac cattgtggct
     2401 gccgtggagg aaggccgtgc catctacaac aacatgaagc agttcatccg ctacctcatt
     2461 tcctccaatg tgggcgaggt ggtctgtatc ttcttgacag cagccttggg gctgcctgag
     2521 gccttgatcc ctgtgcagct gctatgggtg aacttggtga ctgatgggct ccctgctact
     2581 gccctggggt tcaacccacc tgacctggac atcatggacc gtccccccag gagtcccaag
     2641 gagcctctta tcagtggctg gctctttttc cgctacatgg caattggggg ctacgtgggt
     2701 gcagccactg tgggagcagc tgcctggtgg ttcttgtatg cagaggatgg gcctcatgtc
     2761 agctaccatc aactgactca tttcatgcag tgcactgagc ataaccctga atttgatggc
     2821 ctggactgcg aggtctttga agcccccgag cccatgacca tggccttgtc tgtgttggtg
     2881 accatcgaga tgtgcaacgc cctcaacagc ctgtctgaga accagtccct actgcggatg
     2941 ccgccctggg tgaacatctg gcttctcggt tccatctgcc tgtccatgtc cctccacttc
     3001 ctcatcctct atgttgaccc cctgccgatg atcttcaagc tccgggccct ggactttacc
     3061 cagtggctca tggtcctcaa gatctcactt ccagtcatcg ggctagatga gcttctcaag
     3121 ttcattgctc ggaactatct ggagggataa ccacccccct cctccatgtc tttgaaccgt
     3181 gtcacagatc cagaagacga aagaaggaag taaccagccc ttgtgccctg tcttccccac
     3241 cctaatggca aggcgtcttc agccaaagct gaagcacaga gccttcttcc ccttgattct
     3301 gtttataaat aaagttcccc accctcgttc ccttcagcaa cctgctctcc ctctgaacct
     3361 tgtaaatccc cttcccgacc tcacgacctc acggggctta cagggacaag gcaactagct
     3421 gactgcttat ttattgaaaa taaatgacag aaaagtc
//