From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens lysyl hydroxylase (PLOD) mRNA, complete cds.
Date: 21 Dec 92 20:31:53 GMT
Distribution: bionet
Checksum: 29625 7

LOCUS       HUMPLOD      3115 bp ss-mRNA            PRI       17-NOV-1992
DEFINITION  Homo sapiens lysyl hydroxylase (PLOD) mRNA, complete cds.
ACCESSION   L06419
KEYWORDS    lysyl hydroxylase; procollagen-lysine,2-oxoglutarate 5-dioxygenase.
SOURCE      Homo sapiens placenta cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Hautala,T., Eddy,R.L., Shows,T.T., Kivirikko,K.I., Myllylae,R. and
            Byers,M.G.
  TITLE     Cloning of human lysyl hydroxylase: complete cDNA-derived amino
            acid sequence and assignment of the gene (PLOD) to chromosome
            1p36.3-p36.2
  JOURNAL   Genomics 13, 62-69 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     polyA_site      3115
                     /gene="PLOD"
     CDS             201..2384
                     /function="Hydroxylates lysines in collagen like protein
                     sequences"
                     /EC_number="1.14.11.4"
                     /standard_name="procollagen-lysine,2-oxoglutarate
                     5-dioxygenase"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
                     /gene="PLOD"
                     /product="lysyl hydroxylase"
                     /codon_start=1
                     /translation="MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRF
                     KRSAQFFNYKIQALGLGEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFTDSY
                     DVLFASGPRELLKKFRQARSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGY
                     APNLSKLVAEWEGQDSDSDQLFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVV
                     LKFEMGHVRARNLAYDTLPVLIHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRS
                     LKGIGDEALPTVLVGVFIEQPTPFVSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVE
                     EFLAQHGSEYQSVKLVGPEVRMANADARNMGADLCRQDRSCTYYFSVDADVALTEPNS
                     LRLLIQQNKNVIAPLMTRHGRLWSNFWGALSADGYYARSEDYVDIVQGRRVGVWNVPY
                     ISNIYLIKGSALRGELQSSDLFHHSKLDPDMAFCANIRQQDVFMFLTNRHTLGHLLSL
                     DSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYTKALAGKLVETPCPDVYWFPIFTEVAC
                     DELVEEMEHFGQWSLGNNKDNRIQGGYENVPTIDIHMNQIGFEREWHKFLLEYIAPMT
                     EKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGVDYEGGGCRF
                     LRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYIAVSFVDP"
BASE COUNT      667 a    927 c    880 g    641 t
ORIGIN      
        1 ccaccatatc ggtcccgtat ttcacattga taaggtcctg tttcatttct cgtgacattg
       61 ggtagaatga ggatcctgtt ttcaatgggt cgctttaccc tgggactgac agggaggctc
      121 tgaccattta gccaccaaat gtaggtgtag ttctcactct taggttcacc ccgcggccga
      181 tcgtccccca tacctcggcc atgcggcccc tgctgctact ggccctgctg ggctggctgc
      241 tgctggccga agcgaagggc gacgccaagc cggaggacaa ccttttagtc ctcacggtgg
      301 ccactaagga gaccgaggga ttccgtcgct tcaagcgctc agctcagttc ttcaactaca
      361 agatccaggc gcttggccta ggggaggact ggaatgtgga gaaggggacg tcggcaggtg
      421 gagggcagaa ggtccggctg ctgaagaaag ctctggagaa gcacgcagac aaggaggatc
      481 tggtcattct cttcacagac agctatgacg tgctgtttgc atcggggccc cgggagctcc
      541 tgaagaagtt ccggcaggcc aggagccagg tggtcttctc tgctgaggag ctcatctacc
      601 cagaccgcag gctggagacc aagtatccgg tggtgtccga tggcaagagg ttcctgggct
      661 ctggaggctt catcggttat gcccccaacc tcagcaaact ggtggccgag tgggagggcc
      721 aggacagcga cagcgatcag ctgttttaca ccaagatctt cttggacccg gagaagaggg
      781 agcagatcaa tatcaccctg gaccaccgct gccgtatctt ccagaacctg gatggagcct
      841 tggatgaggt cgtgctcaag tttgaaatgg gccatgtgag agcgaggaac ctggcctatg
      901 acaccctccc ggtcctgatc catggcaacg ggccaaccaa gctgcagttg aactacctgg
      961 gcaactacat cccgcgcttc tggaccttcg aaacaggctg caccgtgtgt gacgaaggct
     1021 tgcgcagcct caagggcatt ggggatgaag ctctgcccac ggtcctggtc ggcgtgttca
     1081 tcgaacagcc cacgccgttt gtgtccctgt tcttccagcg gctcctgcgg ctccactacc
     1141 cccagaaaca catgcgactt ttcatccaca accacgagca gcaccacaag gctcaggtgg
     1201 aagagttcct ggcacagcat ggcagcgagt accagtctgt gaagctggtg ggccctgagg
     1261 tgcggatggc gaatgcagat gccaggaaca tgggcgcaga cctgtgccgg caggaccgca
     1321 gctgcaccta ctacttcagc gtggatgctg acgtggccct gaccgagccc aacagcctgc
     1381 ggctgctgat ccaacagaac aagaatgtca ttgccccgct gatgacccgg catgggaggc
     1441 tgtggtcgaa cttctggggg gctctcagtg cagatggcta ctatgcccgt tccgaggact
     1501 acgtggacat tgtgcagggg cggcgtgttg gtgtctggaa tgtgccctat atttcaaaca
     1561 tctacttgat caagggcagt gccctgcggg gtgagctgca gtcctcagat ctcttccacc
     1621 acagcaagct ggaccccgac atggccttct gtgccaacat ccggcagcag gatgtgttca
     1681 tgttcctgac caaccggcac acccttggcc atctgctctc cctagacagc taccgcacca
     1741 cccacctgca caacgacctc tgggaggtgt tcagcaaccc cgaggactgg aaggagaagt
     1801 acatccacca gaactacacc aaagccctgg cagggaagct ggtggagacg ccctgcccgg
     1861 atgtctattg gttccccatc ttcacggagg tggcctgtga tgagctggtg gaggagatgg
     1921 agcactttgg ccagtggtct ctgggcaaca acaaggacaa ccgcatccag ggtggctacg
     1981 agaacgtgcc gactattgac atccacatga accagatcgg ctttgagcgg gagtggcaca
     2041 aattcctgct ggagtacatt gcgcccatga cggagaagct ctaccccggc tactacacca
     2101 gggcccagtt tgacctggcc tttgtcgtcc gctacaagcc tgatgagcag ccctcactga
     2161 tgccacacca tgatgcctcc accttcacca tcaacatcgc cctgaaccga gtcggggtgg
     2221 attacgaggg cgggggctgt cggttcctgc gctacaactg ttccatccga gccccaagga
     2281 agggctggac cctcatgcac cctggacgac tcacgcatta ccatgagggg ctccccacca
     2341 ccaggggcac ccgctacatc gcagtctcct tcgtcgatcc ctaattggcc aggcctgacc
     2401 ctcttggacc tttcttcttt gccgacaacc actgcccagc agcctctggg acctcggggt
     2461 cccagggaac ccagtccagc ctcctggctg ttgacttccc attgctcttg gagccaccaa
     2521 tcaaagagat tcaaagagat tcctgcaggc cagaggccgg aacacacctt tatggctggg
     2581 gctctccgtg gtgttctgga cccagcccct ggagacacca ttcactttta ctgctttgta
     2641 gtgactcgtg ctctccaacc tgtcttcctg aaaaaccaag gcccccttcc cccacctctt
     2701 ccatggggtg agacttgagc agaacagggg cttccccaag ttgcccagaa agactgtctg
     2761 ggtgagaagc catggccaga gcttctccca ggcacaggtg ttgcaccagg gacttctgct
     2821 tcaagttttg gggtaaagac acctggatca gactccaagg gctgccctga gtctgggact
     2881 tctgcctcca tggctggtca tgagagcaaa ccgtagtccc ctggagacag ccactccaga
     2941 gaacctcttg ggagacagaa gaggcatctg tgcacagctc gatcttctac ttgcctgtgg
     3001 ggaggggagt gacaggtcca cacaccacac tgggtcaccc tgtcctggat gcctctgaag
     3061 agagggacag accgtcagaa actggagagt ttctattaaa ggtcatttaa accac
//