From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human aminoacylase-1 (ACY1) mRNA, complete cds.
Date: 29 Dec 92 01:27:49 GMT
Distribution: bionet
Checksum: 21336 5

LOCUS       HUMACYPRO    1415 bp ss-mRNA            PRI       08-DEC-1992
DEFINITION  Human aminoacylase-1 (ACY1) mRNA, complete cds.
ACCESSION   L07548
KEYWORDS    amidohydrolase; amino acid hydrolysis; aminoacylase-1;
            cross-hybridizing DNA.
SOURCE      Homo sapiens (library: Lambda gt10; Lamda gt11) kidney, liver cDNA
            to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Miller,Y.E., Drabkin,H.A., Jones,C. and Fisher,J.H.
  TITLE     Human aminoacylase-1: cloning, regional assignment to distal
            chromosome 3p21.1, and identification of a cross-hybridizing
            sequence on chromosome 18.
  JOURNAL   Genomics 8, 149-154 (1990)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Cook,R.M., Burke,B.J., Buchhagen,D.L., Minna,J.D. and Miller,Y.E.
  TITLE     Human aminoacylase-1: Cloning, sequence and expression analysis of
            a chromosome 3p21 gene inactivated in small cell lung cancer
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..61
                     /gene="ACY1"
     3'UTR           1289..1415
                     /gene="ACY1"
     CDS             62..1288
                     /function="hydrolysis of n-acylated or n-acetylated
                     aminoacids"
                     /EC_number="3.5.1.14"
                     /standard_name="n-acyl-l-aminoacid amidohydrolase"
                     /gene="ACY1"
                     /citation=[2]
                     /note="putative"
                     /product="aminoacylase-1"
                     /codon_start=1
                     /translation="MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQ
                     LGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDS
                     EGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQ
                     RPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEK
                     LHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFR
                     VAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDM
                     NLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYT
                     RLLPALASVPALPSDS"
BASE COUNT      297 a    416 c    416 g    286 t
ORIGIN      
        1 gggcgctgag aggcgagcgt gagcccagcg acaggagagt gagctcacca cgcgcagcgc
       61 catgaccagc aagggtcccg aggaggagca cccatcggtg acgctcttcc gccagtacct
      121 gcgtatccgc actgtccagc ccaagcctga ctatggagct gctgtggctt tctttgagga
      181 gacagcccgc cagctgggcc tgggctgtca gaaagtagag gtggcacctg gctatgtggt
      241 gaccgtgttg acctggccag gcaccaaccc tacactctcc tccatcttgc tcaactccca
      301 cacggatgtg gtgcctgtct tcaaggaaca ttggagtcac gacccctttg aggccttcaa
      361 ggattctgag ggctacatct atgccagggg tgcccaggac atgaagtgcg tcagcatcca
      421 gtacctggaa gctgtgagga ggctgaaggt ggagggccac cggttcccca gaaccatcca
      481 catgaccttt gtgcctgatg aggaggttgg gggtcaccaa ggcatggagc tgttcgtgca
      541 gcggcctgag ttccacgccc tgagggcagg ctttgccctg gatgagggca tagccaatcc
      601 cactgatgcc ttcactgtct tttatagtga gcggagtccc tggtgggtgc gggttaccag
      661 cactgggagg ccaggccatg cctcacgctt catggaggac acagcagcag agaagctgca
      721 caaggttgta aactccatcc tggcattccg ggagaaggaa tggcagaggc tgcagtcaaa
      781 cccccacctg aaagaggggt ccgtgacctc cgtgaacctg actaagctag agggtggcgt
      841 ggcctataac gtgatacctg ccaccatgag cgccagcttt gacttccgtg tggcaccgga
      901 tgtggacttc aaggcttttg aggagcagct gcagagctgg tgccaggcag ctggcgaggg
      961 ggtcacccta gagtttgctc agaagtggat gcacccccaa gtgacaccta ctgatgactc
     1021 aaacccttgg tgggcagctt ttagccgggt ctgcaaggat atgaacctca ctctggagcc
     1081 tgagatcatg cctgctgcca ctgacaaccg ctatatccgc gcggtggggg tcccagctct
     1141 aggcttctca cccatgaacc gcacacctgt gctgctgcac gaccacgatg aacggctgca
     1201 tgaggctgtg ttcctccgtg gggtggacat atatacacgc ctgctgcctg cccttgccag
     1261 tgtgcctgcc ctgcccagtg acagctgagc cctggaactc ctaaaccttt gcccctgggg
     1321 cttccatccc aaccagtgcc aaggacctcc tcttccccct tccaaataat aaagtctatg
     1381 gacagggctg tctctgaagt actaacacaa ggaca
//