From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human platelet-derived growth factor alpha mRNA, complete cds.
Date: 29 Sep 92 10:06:55 GMT
Distribution: bionet
Checksum: 55582    11

LOCUS       HUMPDGFRAA   6378 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human platelet-derived growth factor alpha mRNA, complete cds.
ACCESSION   M21574
KEYWORDS    platelet-derived growth factor.
SOURCE      Homo sapiens infant brain cDNA to mRNA; and Homo sapiens adult cDNA
            to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 6378)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.A.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243, 800-804 (1989)
  STANDARD  full staff_entry
COMMENT     Draft entry and computer-readable sequence for [1] kindly submitted
            by S.Tronick, 29-NOV-1988.
FEATURES             Location/Qualifiers
     mRNA            <1..6378
                     /gene="PDGFA"
     CDS             140..3409
                     /product="platelet-derived growth factor alpha"
                     /gene="PDGFA"
                     /codon_start=1
                     /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS
                     FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY
                     NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT
                     LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM
                     EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT
                     VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH
                     FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY
                     TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC
                     KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG
                     AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS
                     PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV
                     AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL
                     VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT
                     QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF
                     TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF
                     LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR
                     MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS
                     DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE
                     EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF
                     L"
     sig_peptide     140..211
                     /gene="PDGFA"
                     /codon_start=1
     mat_peptide     212..3406
                     /product="platelet-derived growth factor alpha"
                     /gene="PDGFA"
                     /codon_start=1
BASE COUNT     1850 a   1298 c   1445 g   1785 t
ORIGIN
        1 cccattactg ttggagctac agggagagaa acaggaggag actgcaagag atcatttggg
       61 aaggccgtgg gcacgctctt tactccatgt gtgggacatt cattgcggaa taacatcgga
      121 ggagaagttt cccagagcta tggggacttc ccatccggcg ttcctggtct taggctgtct
      181 tctcacaggg ctgagcctaa tcctctgcca gctttcatta ccctctatcc ttccaaatga
      241 aaatgaaaag gttgtgcagc tgaattcatc cttttctctg agatgctttg gggagagtga
      301 agtgagctgg cagtacccca tgtctgaaga agagagctcc gatgtggaaa tcagaaatga
      361 agaaaacaac agcggccttt ttgtgacggt cttggaagtg agcagtgcct cggcggccca
      421 cacagggttg tacacttgct attacaacca cactcagaca gaagagaatg agcttgaagg
      481 caggcacatt tacatctatg tgccagaccc agatgtagcc tttgtacctc taggaatgac
      541 ggattattta gtcatcgtgg aggatgatga ttctgccatt ataccttgtc gcacaactga
      601 tcccgagact cctgtaacct tacacaacag tgagggggtg gtacctgcct cctacgacag
      661 cagacagggc tttaatggga ccttcactgt agggccctat atctgtgagg ccaccgtcaa
      721 aggaaagaag ttccagacca tcccatttaa tgtttatgct ttaaaagcaa catcagagct
      781 ggatctagaa atggaagctc ttaaaaccgt gtataagtca ggggaaacga ttgtggtcac
      841 ctgtgctgtt tttaacaatg aggtggttga ccttcaatgg acttaccctg gagaagtgaa
      901 aggcaaaggc atcacaatgc tggaagaaat caaagtccca tccatcaaat tggtgtacac
      961 tttgacggtc cccgaggcca cggtgaaaga cagtggagat tacgaatgtg ctgcccgcca
     1021 ggctaccagg gaggtcaaag aaatgaagaa agtcactatt tctgtccatg agaaaggttt
     1081 cattgaaatc aaacccacct tcagccagtt ggaagctgtc aacctgcatg aagtcaaaca
     1141 ttttgttgta gaggtgcggg cctacccacc tcccaggata tcctggctga aaaacaatct
     1201 gactctgatt gaaaatctca ctgagatcac cactgatgtg gaaaagattc aggaaataag
     1261 gtatcgaagc aaattaaagc tgatccgtgc taaggaagaa gacagtggcc attatactat
     1321 tgtagctcaa aatgaagatg ctgtgaagag ctatactttt gaactgttaa ctcaagttcc
     1381 ttcatccatt ctggacttgg tcgatgatca ccatggctca actgggggac agacggtgag
     1441 gtgcacagct gaaggcacgc cgcttcctga tattgagtgg atgatatgca aagatattaa
     1501 gaaatgtaat aatgaaactt cctggactat tttggccaac aatgtctcaa acatcatcac
     1561 ggagatccac tcccgagaca ggagtaccgt ggagggccgt gtgactttcg ccaaagtgga
     1621 ggagaccatc gccgtgcgat gcctggctaa gaatctcctt ggagctgaga accgagagct
     1681 gaagctggtg gctcccaccc tgcgttctga actcacggtg gctgctgcag tcctggtgct
     1741 gttggtgatt gtgatcatct cacttattgt cctggttgtc atttggaaac agaaaccgag
     1801 gtatgaaatt cgctggaggg tcattgaatc aatcagcccg gatggacatg aatatattta
     1861 tgtggacccg atgcagctgc cttatgactc aagatgggag tttccaagag atggactagt
     1921 gcttggtcgg gtcttggggt ctggagcgtt tgggaaggtg gttgaaggaa cagcctatgg
     1981 attaagccgg tcccaacctg tcatgaaagt tgcagtgaag atgctaaaac ccacggccag
     2041 atccagtgaa aaacaagctc tcatgtctga actgaagata atgactcacc tggggccaca
     2101 tttgaacatt gtaaacttgc tgggagcctg caccaagtca ggccccattt acatcatcac
     2161 agagtattgc ttctatggag atttggtcaa ctatttgcat aagaataggg atagcttcct
     2221 gagccaccac ccagagaagc caaagaaaga gctggatatc tttggattga accctgctga
     2281 tgaaagcaca cggagctatg ttattttatc ttttgaaaac aatggtgact acatggacat
     2341 gaagcaggct gatactacac agtatgtccc catgctagaa aggaaagagg tttctaaata
     2401 ttccgacatc cagagatcac tctatgatcg tccagcctca tataagaaga aatctatgtt
     2461 agactcagaa gtcaaaaacc tcctttcaga tgataactca gaaggcctta ctttattgga
     2521 tttgttgagc ttcacctatc aagttgcccg aggaatggag tttttggctt caaaaaattg
     2581 tgtccaccgt gatctggctg ctcgcaacgt cctcctggca caaggaaaaa ttgtgaagat
     2641 ctgtgacttt ggcctggcca gagacatcat gcatgattcg aactatgtgt cgaaaggcag
     2701 tacctttctg cccgtgaagt ggatggctcc tgagagcatc tttgacaacc tctacaccac
     2761 actgagtgat gtctggtctt atggcattct gctctgggag atcttttccc ttggtggcac
     2821 cccttacccc ggcatgatgg tggattctac tttctacaat aagatcaaga gtgggtaccg
     2881 gatggccaag cctgaccacg ctaccagtga agtctacgag atcatggtga aatgctggaa
     2941 cagtgagccg gagaagagac cctcctttta ccacctgagt gagattgtgg agaatctgct
     3001 gcctggacaa tataaaaaga gttatgaaaa aattcacctg gacttcctga agagtgacca
     3061 tcctgctgtg gcacgcatgc gtgtggactc agacaatgca tacattggtg tcacctacaa
     3121 aaacgaggaa gacaagctga aggactggga gggtggtctg gatgagcaga gactgagcgc
     3181 tgacagtggc tacatcattc ctctgcctga cattgaccct gtccctgagg aggaggacct
     3241 gggcaagagg aacagacaca gctcgcagac ctctgaagag agtgccattg agacgggttc
     3301 cagcagttcc accttcatca agagagagga cgagaccatt gaagacatcg acatgatgga
     3361 cgacatcggc atagactctt cagacctggt ggaagacagc ttcctgtaac tggcggattc
     3421 gaggggttcc ttccacttct ggggccacct ctggatcccg ttcagaaaac cactttattg
     3481 caatgcggag gttgagagga ggacttggtt gatgtttaaa gagaagttcc cagccaaggg
     3541 cctcggggag cgttctaaat atgaatgaat gggatatttt gaaatgaact ttgtcagtgt
     3601 tgcctctcgc aatgcctcag tagcatctca gtggtgtgtg aagtttggag atagatggat
     3661 aagggaataa taggccacag aaggtgaact ttgtgcttca aggacattgg tgagagtcca
     3721 acagacacaa tttatactgc gacagaactt cagcattgta attatgtaaa taactctaac
     3781 caaggctgtg tttagattgt attaactatc ttctttggac ttctgaagag accactcaat
     3841 ccatccatgt acttccctct tgaaacctga tgtcagctgc tgttgaactt tttaaagaag
     3901 tgcatgaaaa accatttttg aaccttaaaa ggtactggta ctatagcatt ttgctatctt
     3961 ttttagtgtt aagagataaa gaataataat taaccaacct tgtttaatag atttgggtca
     4021 tttagaagcc tgacaactca ttttcatatt gtaatctatg tttataatac tactactgtt
     4081 atcagtaatg ctaaatgtgt aataatgtaa catgatttcc ctccagagaa agcacaattt
     4141 aaaacaatcc ttactaagta ggtgatgagt ttgacagttt ttgacattta tattaaataa
     4201 catgtttctc tataaagtat ggtaatagct ttagtgaatt aaatttagtt gagcatagag
     4261 aacaaagtaa aagtagtgtt gtccaggaag tcagaatttt taactgtact gaataggttc
     4321 cccaatccat cgtattaaaa aacaattaac tgccctctga aataatggga ttagaaacaa
     4381 acaaaactct taagtcctaa aagttctcaa tgtagaggca taaacctgtg ctgaacataa
     4441 cttctcatgt atattaccca atggaaaata taatgatcag caaaaagact ggatttgcag
     4501 aagttttttt tttttttctt catgcctgat gaaagctttg gcaaccccaa tatatgtatt
     4561 ttttgaatct atgaacctga aaagggtcag aaggatgccc agacatcagc ctccttcttt
     4621 caccccttac cccaaagaga aagagtttga aactcgagac cataaagata ttctttagtg
     4681 gaggctggat gtgcattagc ctggatcctc agttctcaaa tgtgtgtggc agccaggatg
     4741 actagatcct gggtttccat ccttgagatt ctgaagtatg aagtctgagg gaaaccagag
     4801 tctgtatttt tctaaactcc ctggctgttc tgatcggcca gttttcggaa acactgactt
     4861 aggtttcagg aagttgccat gggaaacaaa taatttgaac tttggaacag ggttggaatt
     4921 caaccacgca ggaagcctac tatttaaatc cttggcttca ggttagtgac atttaatgcc
     4981 atctagctag caattgcgac cttaatttaa ctttccagtc ttagctgagg ctgagaaagc
     5041 taaagtttgg ttttgacagg ttttccaaaa gtaaagatgc tacttcccac tgtatggggg
     5101 agattgaact ttccccgtct cccgtcttct gcctcccact ccataccccg ccaaggaaag
     5161 gcatgtacaa aaattatgca attcagtgtt ccaagtctct gtgtaaccag ctcagtgttt
     5221 tggtggaaaa aacattttaa gttttactga taatttgagg ttagatggga ggatgaattg
     5281 tcacatctat ccacactgtc aaacaggttg gtgtgggttc attggcattc tttgcaatac
     5341 tgcttaattg ctgataccat atgaatgaaa catgggctgt gattactgca atcactgtgc
     5401 tatcggcaga tgatgctttg gaagatgcag aagcaataat aaagtacttg actacctact
     5461 ggtgtaatct caatgcaagc cccaactttc ttatccaact ttttcatagt aagtgcgaag
     5521 actgagccag attggccaat taaaaacgaa aacctgacta ggttctgtag agccaattag
     5581 acttgaaata cgtttgtgtt tctagaatca cagctcaagc attctgttta tcgctcactc
     5641 tcccttgtac agccttattt tgttggtgct ttgcattttg atattgctgt gagccttgca
     5701 tgacatcatg aggccggatg aaacttctca gtccagcagt ttccagtcct aacaaatgct
     5761 cccacctgaa tttgtatatg actgcatttg tgggtgtgtg tgtgttttca gcaaattcca
     5821 gatttgtttc cttttggcct cctgcaaagt ctccagaaga aaatttgcca atctttccta
     5881 ctttctattt ttatgatgac aatcaaagcc ggcctgagaa acactatttg tgacttttta
     5941 aacgattagt gatgtcctta aaatgtggtc tgccaatctg tacaaaatgg tcctattttt
     6001 gtgaagaggg acataagata aaatgatgtt atacatcaat atgtatatat gtatttctat
     6061 atagacttgg agaatactgc caaaacattt atgacaagct gtatcactgc cttcgtttat
     6121 atttttttaa ctgtgataat ccccacaggc acattaactg ttgcactttt gaatgtccaa
     6181 aatttatatt ttagaaataa taaaaagaaa gatacttaca tgttcccaaa acaatggtgt
     6241 ggtgaatgtg tgagaaaaac taacttgata gggtctacca atacaaaatg tattacgaat
     6301 gcccctgttc atgtttttgt tttaaaacgt gtaaatgaag atctttatat ttcaataaat
     6361 gatatataat ttaaagtt
//