From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human platelet-derived growth factor A-chain (PDGF) gene, 5' end
Date: 15 Sep 92 10:04:43 GMT
Distribution: bionet
Checksum: 02433     4

LOCUS       HUMPGDF      1790 bp ds-DNA             PRI       15-SEP-1992
DEFINITION  Human platelet-derived growth factor A-chain (PDGF) gene, 5' end
            and promoter region.
ACCESSION   M59423
KEYWORDS    platelet-derived growth factor A-chain.
SOURCE      Human leukocyte DNA, clone B2.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Takimoto,Y., Wang,Z.-Y., Kobler,K. and Deuel,T.F.
  TITLE     Promoter region of the human platelet-derived growth factor A-chain
            gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88, 1686-1690 (1991)
  STANDARD  full staff_entry
REFERENCE   2  (sites)
  AUTHORS   Wang,Z., Lin,X.-H., Qiu,Q.-Q. and Deuel,T.F.
  TITLE     Modulation of transcription of the platelet-derived growth factor
            A-chain gene by a promoter region sensitive to S1 nuclease
  JOURNAL   J. Biol. Chem. 267, 17022-17031 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     promoter        1..1787
                     /gene="PDGFA"
                     /partial
     misc_feature    851..905
                     /note="GC signal"
                     /gene="PDGFA"
                     /partial
     TATA_signal     906..910
                     /gene="PDGFA"
                     /partial
     CDS             1782..1790
                     /product="platelet-derived growth factor A-chain"
                     /gene="PDGFA"
                     /codon_start=1
                     /translation="MRT"
                     /partial
BASE COUNT      195 a    676 c    687 g    232 t
ORIGIN
        1 agggaggcga aatccatcca gcccagcgca ccgccctttc tcggcgtggg agccgtctag
       61 ccacgctcag acctcggcct ccgcgcgcgt tcctccccca tcgcgctctg actgcgcctc
      121 ggccggaggt gctctgtgcg ccccacggat ccgacgcggg aggctcagaa cccgggggac
      181 cctcaccggt ggctcctttc ccttccatcc cctcgacttc ccggctcagg cgcggcccct
      241 tcggcgcggg agtgggggac tggggggcgc ggggtcccag ggtggggacg aggcggctgc
      301 aggccctttc cccgactgga gctcgctccc aagtggaaat gtgggtggag ggtcctcatt
      361 cagatgcccc aggcctcgga tcctgggcgg gggcgcgtgg cagccgcagg tgagtgcccc
      421 aaacccgccc ccctccttcc ccaaagactg actccccctc cttttatgga gagaggaagg
      481 ctggggcctg gatccgaacc gtggagagcg gccggagcgc gggcggggcg gggacggctc
      541 tctggccctt tttggcgcaa gctctgggcg ctgcgctgcc gcgtgggccc gagagaggcg
      601 agccgcgacg gcgcttctgc ggcggcctcc tccctcccca cccggtgccg cagattgcag
      661 ctggcactgg agggtgggca agctcgaggg aggggcgcgg agcgcgcgga gcgcgcgggg
      721 ctttgatgga tttagctgct tgcgcgagcg cgtgtgtgct ccctgccgcg gcggcggcgc
      781 ccgggccctg ccgggtccgc acgaacccct agcgcttccg aggtgcgggt cccaggcccg
      841 gaatccgggg aggcgggggg gggggggcgg gggcgggggc gggggagggg cgcggcggcg
      901 gcggctataa ccctctcccc gccgccggcc ggctccacac gcgcgccctg cggagcccgc
      961 ccaactccgg cgagccggcc tgcgcctact cctcctcctc ctctcccggc ggcggctgcg
     1021 gcggaggcgc cgactcggcc ttgcgccgcc ctcaggcccg cgcggccggc gcagcgaggc
     1081 cccgggcggc gggtggtggc tgccaggcgg ctcggccggc cgcgcgctgc ccggccccgg
     1141 ccgagcggag ggcggacgcc ggcgccggga gccgagggcc gccgcggagg gggtgctgcg
     1201 gccgcgctgt gcccggccgg gcggcggctg caagaggagg ccggaggcga gcgcggggcc
     1261 ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg gccgggccag gcgtccaggc
     1321 aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga ctccctccgg agttcttctt
     1381 cggggctcga tgtccgcaaa tatggcagaa tgtaccggcc gggtcgctcc tgaagccagc
     1441 gcggggagcg agcgcggcgg cggccagcac cgggaacgca ccgaggaaga agcccagccc
     1501 ccgccctccg ccccttccgt ccccaccccc taccggcggc ccaggaggct ccccgcgctg
     1561 gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc ctgcctctcc gcactcactg
     1621 ctcgcgccgg gcggctccgc cagctccgtg ctccccgcgc caccctcctc cgggccgcgc
     1681 tccctaaggg atggtactga atttcgccgc cacaggagac cggctggagc gccgccccgc
     1741 ggcctcgcct ctcctccgag cagccagcgc ctcgggacgc gatgaggacc
//