From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Bovine phophatidylinositol 3-kinase 110 kDa subunit mRNA, complete
Date: 20 Aug 92 10:00:59 GMT
Distribution: bionet
Checksum: 07860     7

LOCUS       BOVPHOS3KN   3207 bp ss-mRNA            MAM       20-AUG-1992
DEFINITION  Bovine phophatidylinositol 3-kinase 110 kDa subunit mRNA, complete
            cds.
ACCESSION   M93252
KEYWORDS    phophatidylinositol 3-kinase.
SOURCE      Bos taurus cDNA to mRNA.
  ORGANISM  Bos taurus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae;
            Bovini.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Hiles,I.D., Otsu,M., Volinia,S., Fry,M.J., Gout,I., Dhan,R.,
            Panayotou,G., Ruiz-Larrea,F., Thompson,A., Totty,N.F., Hsuan,J.J.,
            Courtneidge,S.A., Parker,P.J. and Waterfield,M.D.
  TITLE     Phosphatidylinositol 3-kinase: Structure and expression of the 110
            kd catalytic subunit
  JOURNAL   Cell 70, 419-429 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             1..3207
                     /EC_number="2.7.1.67"
                     /product="phophatidylinositol 3-kinase"
                     /codon_start=1
                     /translation="MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLIT
                     IKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVI
                     EPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPH
                     SRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPE
                     QVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSC
                     IMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSAL
                     RIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIY
                     IPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH
                     GLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSY
                     SHAGLSNRLARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVTIPEILP
                     KLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLT
                     DDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQ
                     RFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMR
                     RPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNE
                     IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHT
                     IMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIG
                     DRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECT
                     KTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDK
                     TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN"
BASE COUNT     1028 a    581 c    680 g    918 t
ORIGIN
        1 atgcctccaa gaccatcatc aggtgaactg tggggcatcc acttgatgcc cccaagaatc
       61 ctagtagaat gtttactacc aaatgggatg atagtgactt tagaatgcct ccgtgaggct
      121 acgttaataa cgataaagca tgaactattt aaagaagcaa gaaaataccc tctccatcaa
      181 cttcttcaag atgaatcttc ttacattttc gtaagtgtta cccaagaagc agaaagggaa
      241 gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa
      301 gtaattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgct
      361 atcggcatgc cagtgtgtga attcgatatg gttaaagatc cagaagtaca ggacttccga
      421 agaaatattc tcaatgtttg taaagaagct gtggatctta gggatcttaa ttcacctcat
      481 agtagagcaa tgtatgttta tcctccaaat gtagaatctt caccagaact gccaaagcac
      541 atatataata aattggataa agggcaaata atagtggtga tttgggtaat agtttctcca
      601 aataatgaca aacagaagta tactctgaaa atcaaccatg actgtgtgcc agaacaagta
      661 attgctgaag caatcaggaa aaaaactcga agtatgttgc tatcatctga acaactaaaa
      721 ctctgtgttt tagaatatca gggcaagtat attttaaaag tgtgtggatg tgatgaatac
      781 ttcctagaaa aatatcctct gagtcagtat aagtatataa gaagctgtat aatgcttggg
      841 aggatgccca atttgatgct gatggctaaa gaaagcctct attctcaact gccaatggac
      901 tgttttacaa tgccatcata ttccagacgc atctccacag ctacgccata tatgaatgga
      961 gaaacatcta caaaatccct ttgggttata aatagtgcac tcagaataaa aattctttgt
     1021 gcaacctatg tgaatgtaaa tattcgagac attgacaaga tttatgttcg aacaggtatc
     1081 taccatggag gagaaccctt atgtgataat gtgaacactc aaagagtacc ttgttccaat
     1141 cccaggtgga atgaatggct gaattacgat atatacattc ctgatcttcc tcgtgctgct
     1201 cgactttgcc tttccatttg ttctgttaaa ggccgaaagg gtgctaaaga ggaacactgt
     1261 ccattggcct ggggaaatat aaacttgttt gattacacag atactctagt atctggaaaa
     1321 atggctttga atctttggcc agtacctcat ggactagaag atttgctgaa ccctattggt
     1381 gttactggat caaatccaaa taaagaaact ccatgtttag agttggagtt tgactggttc
     1441 agcagtgtgg taaagtttcc agatatgtca gtgattgaag agcatgccaa ttggtctgta
     1501 tcccgtgaag caggatttag ttattcccat gcaggactga gtaacagact agctagagac
     1561 aatgaattaa gagaaaatga taaagaacag ctccgagcaa tttgtacacg agatcctcta
     1621 tctgaaatca ctgagcaaga gaaagatttt ctgtggagcc acagacacta ttgtgtaact
     1681 atccccgaaa ttctacccaa attgcttctg tctgttaaat ggaactctag agatgaagta
     1741 gctcagatgt actgcttggt aaaagattgg cctccaatca agcctgaaca ggctatggag
     1801 cttctggact gcaattaccc agatcctatg gttcgaggtt ttgctgttcg gtgcttagaa
     1861 aaatatttaa cagatgacaa actttctcag tacctaattc agctagtaca ggtactaaaa
     1921 tatgaacagt atttggataa cctgcttgtg agatttttac tcaaaaaagc gttaactaat
     1981 caaaggatcg gtcacttttt cttttggcat ttaaaatctg agatgcacaa taaaacagtt
     2041 agtcagaggt ttggcctgct tttggagtcc tattgccgtg catgtgggat gtatctgaag
     2101 caccttaata ggcaagttga ggctatggaa aagctcatta acttgactga cattctcaaa
     2161 caagagaaga aggatgaaac acaaaaggta cagatgaagt ttttagttga gcaaatgcgg
     2221 cgaccagatt tcatggatgc tctccagggc tttctgtctc ctctaaaccc tgctcatcag
     2281 ctgggaaatc tcaggcttga agagtgtcga attatgtctt ctgcaaaaag gccactgtgg
     2341 ttgaattggg agaacccaga catcatgtca gaattactct ttcagaacaa tgagatcatc
     2401 tttaaaaatg gggatgattt acggcaagat atgctaaccc ttcagattat tcgcattatg
     2461 gaaaatatct ggcaaaatca aggtcttgat cttcgaatgt taccttatgg atgtctgtca
     2521 atcggtgact gtgtgggact tatcgaggtg gtgagaaatt ctcacactat aatgcagatt
     2581 cagtgtaaag gaggcctgaa aggtgcactg cagtttaaca gccacacact ccatcagtgg
     2641 ctcaaagaca agaacaaggg ggaaatatat gatgcggcca tcgatttgtt tacacgatca
     2701 tgtgctggat attgtgttgc caccttcatt ttgggaattg gagatcgtca caatagtaat
     2761 atcatggtta aagatgatgg acaactgttt catatagatt ttggacactt tttggatcac
     2821 aagaagaaaa aatttggtta taaacgagag cgcgtgccgt ttgttttgac acaagatttc
     2881 ttaatagtga ttagtaaagg agcccaagaa tgcacaaaga caagagaatt tgagaggttt
     2941 caggagatgt gttacaaggc ttatctagct attcggcagc atgccaatct cttcataaat
     3001 cttttctcaa tgatgcttgg ctctggaatg ccagaactgc aatcttttga tgatattgca
     3061 tacattcgaa agaccctagc tttagataaa actgagcaag aggctttgga gtatttcatg
     3121 aaacaaatga atgatgcaca ccatggtggc tggacaacaa aaatggattg gatcttccac
     3181 acaattaagc agcatgcttt gaactga
//