From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human cell 12-lipoxygenase mRNA, complete cds.
Date: 29 Sep 92 10:07:01 GMT
Distribution: bionet
Checksum: 09884     5

LOCUS       HUMPEC12L    2344 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human cell 12-lipoxygenase mRNA, complete cds.
ACCESSION   M35418
KEYWORDS    lipoxygenase.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Funk,C.D., Furci,L. and FitzGerald,G.A.
  TITLE     Molecular cloning, primary structure, and expression of the human
            platelet/erythroleukemia cell 12-lipoxygenase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87, 5638-5642 (1990)
  STANDARD  full staff_review
COMMENT     Draft entry and computer-readable sequence for [1] kindly submitted
            by C.D.Funk, 20-JUN-1990.
FEATURES             Location/Qualifiers
     mRNA            <1..2344
                     /gene="ALOX12"
     CDS             42..2033
                     /product="12-lipoxygenase"
                     /gene="ALOX12"
                     /codon_start=1
                     /translation="MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARG
                     EEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQG
                     EDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDL
                     PPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKV
                     RQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEA
                     DFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPSPSSPTPTLFLPS
                     DPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFPIPH
                     IRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADR
                     GLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLC
                     QAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPP
                     TTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVL
                     NQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI"
     polyA_signal    2324..2329
                     /gene="ALOX12"
BASE COUNT      514 a    692 c    642 g    496 t
ORIGIN
        1 ggaggacccg gctcccctcg cctaagctgc tggggggcgc catgggccgc taccgcatcc
       61 gcgtggccac cggggcctgg ctcttctccg ggtcgtacaa ccgcgtgcag ctttggctgg
      121 tcgggacgcg cggggaggcg gagctggagc tgcagctgcg gccggcgcgg ggcgaggagg
      181 aggagtttga tcatgacgtt gcagaggact tggggctcct gcagttcgtg aggctgcgca
      241 agcaccactg gctggtggac gacgcgtggt tctgcgaccg catcacggtg cagggccctg
      301 gagcctgcgc ggaggtggcc ttcccgtgct accgctgggt gcagggcgag gacatcctga
      361 gcctgcccga gggcaccgcc cgcctgccag gagacaatgc tttggacatg ttccagaagc
      421 atcgagagaa ggaactgaaa gacagacagc agatctactg ctgggccacc tggaaggaag
      481 ggttacccct gaccatcgct gcagaccgta aggatgatct acctccaaat atgagattcc
      541 atgaggagaa gaggctggac tttgaatgga cactgaaggc aggggctctg gagatggccc
      601 tcaaacgtgt ttacaccctc ctgagctcct ggaactgcct agaagacttt gatcagatct
      661 tctggggcca gaagagtgcc ctggctgaga aggttcgcca gtgctggcag gatgatgagt
      721 tgttcagcta ccagttcctc aatggtgcca accccatgct gttgagacgc tcgacctctc
      781 tgccctccag gctagtgctg ccctcgggga tggaagagct tcaggctcaa ctggagaaag
      841 aacttcagaa tggttccctg tttgaagctg acttcatcct tctggatgga attccagcca
      901 acgtgatccg aggagagaag caatacctgg ctgcccccct cgttatgctg aagatggagc
      961 ccaatgggaa gctgcagccc atggtcatcc agattcagcc tcccagcccc agctctccaa
     1021 ccccaacact gttcctgccc tcagaccccc cacttgcctg gctcctggca aagtcctggg
     1081 tccgaaattc agatttccaa ctgcacgaga tccagtatca cttgctgaac actcacctgg
     1141 tggctgaggt catcgctgtc gccaccatgc ggtgcctccc aggactgcac cccatcttca
     1201 agttcccgat cccccatatc cgctacacca tggaaatcaa cacccgggcc cggacccaac
     1261 tcatctcaga tggaggaatt tttgataagg cagtgagcac aggtggaggg ggccatgtac
     1321 agttgctccg tcgggcggca gctcagctga cctactgctc cctctgtcct cctgacgacc
     1381 tggctgaccg gggcctgctg ggactcccag gtgctctcta tgcccatgat gctttacggc
     1441 tctgggagat cattgccagg tatgtggagg ggatcgtcca cctcttctac caaagggatg
     1501 acatagtgaa gggggaccct gagctgcagg cctggtgtcg ggagatcacg gaggtggggc
     1561 tgtgccaggc ccaggaccga ggtttccctg tctccttcca gtcccagagt caactctgcc
     1621 atttcctcac catgtgcgtc ttcacgtgca ctgcccagca tgccgccatc aaccagggcc
     1681 agctggactg gtatgcctgg gtccctaatg ctccatgcac aatgcggatg cccccaccca
     1741 ccaccaagga agatgtgacg atggccacag tgatggggtc actacctgat gtccggcagg
     1801 cctgtcttca aatggccatc tcatggcatc tgagtcgccg ccagccagac atggtgcctc
     1861 tggggcacca caaagaaaaa tatttctcag gccccaagcc caaagctgtg ctaaaccaat
     1921 tccgaacaga tttggaaaag ctagaaaagg agattacagc ccggaatgag caacttgact
     1981 ggccctatga atatctgaag cccagctgca tagagaacag tgtcaccatc tgagccctag
     2041 agtgactcta cctgcaagat ttcacatcag ctttaggact gacatttcta tcttgaattt
     2101 catgctttcc taaagtctct gctgctaagg ctctatttcc tcccccagtt aaacccctac
     2161 attagtatcc cactagccca ggggagcagt aaactttctc tgcaaagact agatcctttt
     2221 ttacgctttg cagaccgcat agtcactgtc tcaactactc agctctcctg ctgcagcatg
     2281 aaggcagcca cagacaacat ggaaatgagt gtgactatgt tccaataaaa ctttatggac
     2341 actg
//