From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human gene sequence, 5' end.
Date: 31 Dec 92 01:37:44 GMT
Distribution: bionet
Checksum: 45011 5

LOCUS       HUMSIGPEP    1032 bp ds-DNA             PRI       17-DEC-1992
DEFINITION  Human gene sequence, 5' end.
ACCESSION   M96628
KEYWORDS    .
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Bories,D., Raynal,M.-C., Solomon,D.H., Darzynkiewicz,Z. and
            Cayre,Y.E.
  TITLE     Down-regulation of a serine protease, myeloblastin, causes growth
            arrest and differentiation of promyelocytic leukemia cells
  JOURNAL   Cell 59, 959-968 (1989)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Campanelli,D., Melchior,M., Fu,Y., Nakata,M., Shuman,H., Nathan,C.
            and Gabay,J.E.
  TITLE     Cloning of cDNA for proteinase 3: a serine protease, antibiotic,
            and autoantigen from human neutrophils
  JOURNAL   J. Exp. Med. 172, 1709-1715 (1990)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Labbaye,C., Musette,P. and Cayre,Y.E.
  TITLE     Wegener autoantigen and myeloblastin are encoded by a single mRNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88, 9253-9256 (1991)
  STANDARD  full automatic
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Zimmer,M., Medcalf,R.L., Fink,T.M., Mattmann,C., Lichter,P. and
            Jenne,D.E.
  TITLE     Three human elastase-like genes co-ordinately expressed in the
            myelo-monocyte lineage are organized as a single genetic locus on
            19pter
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 8215-8219 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     GC_signal       498..503
     CAAT_signal     complement(610..614)
     conflict        replace(610,"")
                     /citation=[3]
                     /note="'' in conflict"
     conflict        replace(614,"")
                     /citation=[3]
                     /note="'' in conflict"
     TATA_signal     643..647
     conflict        replace(659,"")
                     /citation=[3]
                     /note="'T' in conflict"
     exon            (666.676)..744
                     /number=1
                     /label=exon1
     5'UTR           669..683
     sig_peptide     684..>744
                     /codon_start=1
     conflict        replace(687..689,"")
                     /citation=[2]
                     /note="'CGG' in conflict"
     intron          745..>1032
                     /number=1
                     /label=intron1
     CDS             684..>744
                     /note="part of signal peptide"
                     /codon_start=1
                     /translation="MAHRPPSPALASVLLALLLS"
BASE COUNT      183 a    339 c    318 g    192 t
ORIGIN      
        1 ggatccttct ctggggcagg cccgtcctgg gcactgcagg gtgctaggca tcatccttgg
       61 cctccaccca ctccatgcca ggagctcccc tttcgtgaca gccacaggtg tcctcagacc
      121 tcacccaggg tcccctgggg gcagaatcac cccttgattg agaatcctgg ccttaaaggg
      181 ggaagaaaac ccccagacaa aactggcagg aggatgttcg ctggggcctc aggtgaggca
      241 ctgagggcac tcgtggtggg gccctgcctt cccgagctct gcatcctgtc ccctgctacg
      301 tcctgctgtc tgtccgtttc cagctcaccc acccacggga cacacctgcc acggccggct
      361 ttgctggggc cacagggacc tcgtcaggga ggcgtctcct tgtgggtggc acgtgggcat
      421 gtgttgctct gagggctgtg gccatgttgc ccacctggcc agggaccccc gacttgggtg
      481 ggtgacagcc agcctccccg cccccacaaa ggtcgggacc ttgagcccaa agcccccacc
      541 tcctccccgg agtccgttct gactcccagg ctcccaaggc aaaaggagga agtggggacc
      601 cagcctgggc attgggcaac tcaacggcct ctggcattgg gctataagag gagcttgacc
      661 gtgggtgcac cctggacccc accatggctc accggccccc cagccctgcc ctggcgtccg
      721 tgctgctggc cttgctgctg agcggtgagt gagccacgtg cccatccatc cagcttccag
      781 gccccggtgg attgtgggga aatatccacc acgaggtcca tccaaagccc ttctggcaca
      841 gctggggaaa ctgaggcagg gtcaggggag actccactca ctgctcggga ccaacgcttg
      901 caggggtggg gaggacaagg gcaaggggga gccctggcca tttgactcag ttgcctatct
      961 gtaaaacggg cggggcccag cccttccctc ctgaggagct gttttgggaa ttagctagta
     1021 acaggcgaat tc
//