From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human DNA, 5'-upstream region of the cytochrome P-450c gene
Date: 21 Jul 92 10:05:24 GMT
Distribution: bionet
Checksum: 02610     9

LOCUS       HUMCYP1A1    4144 bp ds-DNA             PRI       21-JUL-1992
DEFINITION  Human DNA, 5'-upstream region of the cytochrome P-450c gene
            (CYP1A1).
ACCESSION   D10855 D01150
KEYWORDS    Alu sequence; SINE; XRE; nonviral retroposon;
            short interspersed repeated sequence;
            xenobiotic responsive element.
SOURCE      Homo sapiens (library: lambda Charon4A) embryo DNA, clone
            lambdahP-450mc-1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Kawajiri,K., Watanabe,J., Gotoh,O., Tagashira,Y. and Sogawa,k.
  TITLE     Structure and drug inducibility of the human cytochrome P-450c gene
  JOURNAL   Eur. J. Biochem. 159, 219-225 (1986)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
            Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
  TITLE     Xenobiotic responsive element in the 5'-upstream region of the
            human P-450c gene
  JOURNAL   J. Biochem. 110, 232-236 (1991)
  STANDARD  full staff_review
COMMENT
            [1]  sites.
FEATURES             Location/Qualifiers
     repeat_region   1..1017
                     /rpt_type=tandem
                     /rpt_unit=368..404
                     /rpt_unit=405..444
                     /rpt_unit=445..490
                     /rpt_unit=491..539
                     /rpt_unit=540..583
                     /rpt_unit=584..625
                     /rpt_unit=626..663
                     /rpt_unit=664..703
                     /rpt_unit=704..740
                     /rpt_unit=741..779
                     /rpt_unit=780..815
                     /rpt_unit=816..855
                     /rpt_unit=856..895
                     /rpt_unit=896..932
                     /rpt_unit=933..971
                     /rpt_unit=972..1017
     repeat_unit     1018..1107
                     /rpt_family="Alu"
                     /note="half part of Alu"
     misc_feature    1073..1077
                     /note="XRE (xenobiotic responsive element) core sequence
                     CACGC"
     repeat_unit     1129..1375
                     /rpt_family="Alu"
     repeat_unit     1978..2294
                     /rpt_family="Alu"
                     /note="inserted in the opposite direction"
     misc_feature    2760..2764
                     /note="XRE core sequence"
     misc_feature    2942..2946
                     /note="XRE core sequence"
     misc_feature    3031..3035
                     /note="XRE core sequence"
     misc_feature    3160..3164
                     /note="XRE core sequence"
     misc_feature    3248..3252
                     /note="XRE core sequence"
     misc_feature    3644..3648
                     /note="XRE core sequence"
     misc_feature    3747..3751
                     /note="XRE core sequence"
     TATA_signal     4115..4120
BASE COUNT      791 a   1310 c   1223 g    820 t
ORIGIN      Map position 15q22-qter (near MPI).
        1 tccgcagtgt ttgtgtccct gggtacttga gattagggag tggtgatgac tcttaacgag
       61 catgctgcct tcaagcatct gtttaacaaa gcacaacttg cactgccctt aatcccttta
      121 accctgagtg gacacagcac atgtttcaga gggcacaggg ttgggggtaa ggtcacagat
      181 caacaggatc acaaggcaga agaatttttc ttagtacaga acaaaatgaa gagtctccca
      241 tgtctacctc tttctacaca gacacggcaa ccatccgatt tctcaatctt ttccccgctt
      301 ttcccctctt tctattccac aaaaccgcca ttgtcatcat ggcccgttct caatgagctg
      361 ttgggtacac ctcccagatg gggtggtggc cgggcagagg ggctcctcac ttcccagtag
      421 gggcggccgg gcagaggcgc ccctcacctc ccggacgagg cggctggccg ggcggggggc
      481 tgaccccccc acctccctcc cggacagggc ggctggccgg gcggggggct gaccccccca
      541 cctccctccc ggacgggcgg ctggcctggc gggggctacc cccacctccc tcccggacgg
      601 gtggctgccg ggcggagacg ctcctcactt cccagacggg gtggctgccg gcggaggggc
      661 tcctcacttc tcagacgggg cggttgcagg cggagggtct ccttgattct cagacggggc
      721 ggccgggcag agacgctcct cacctcccag acggggtcgc ggctggtaga ggcgctcctc
      781 acatcccaga cggggcagca gggcaaaggc gctccccaca tctcagacga tgggctgccg
      841 ggcagagacg ctcctcactt cctagatggg atggcggtgg ggcagagacg ctcctcactt
      901 tccagactgg gcagccaggc agaggggctc ctcacgtccc agacgatggg cggccaggca
      961 gagacgctcc tcacttccca gacggggtgg cggccgggca gaggctgcaa tctcggcact
     1021 ttgggaggcc aaggcaggcg ggtgggaggt ggaggttgta gcgagccgag atcacgccac
     1081 tgcgctccag cctgggcacc attgagcact gagtgaacca gaatccgtct gcaatcccgg
     1141 cacctcggga ggccgaggct ggcggatcac tccctgttag gagctggaga ccagcccggc
     1201 caacacagcg aaaccccgtc tccaccaaaa aaatacgaaa accagtcagg cgtggcggcg
     1261 cgcgctgcaa tcgcaggact cggcaggctg aggcaggaga atcaggcagg gaggttgcag
     1321 tgagccgaga tggcagcagt acagtccagc tttggctcgg catcagaggg agaccgtgga
     1381 aagaggggac agggagaggg agggagaggg agagggagag ggagagggag agctgctaaa
     1441 gattcttatt cctgccttca gagtggtggg agctaccaaa gaaatttaag caaggtggtg
     1501 atggaatgag attttgcatt tttgacagga ccactctggg tgccacagga tggagaagta
     1561 attggacgga gcaaaaggca aatgggaacc taggtggagg ctaagtgctc cagggagcaa
     1621 tgatgggccc tggatgagtt gtggcagtgg agctggacag atgccaaagc agatgccaag
     1681 cagagaaatg tgcctcctat tcttagcaca gtagcccgag tgaccttgct tctcttacac
     1741 cccagccatg tctctatctc gcacagagga agtctcatgt ctctcaatgg ggtgctccct
     1801 gcacatgcgg cagggcgctg tgcctcatgg gcatcccatc cccctggact acatgccagg
     1861 agaactcccc agtcacatga cctctgcaca tccctggtac tgctcggtcc ttcaagaacc
     1921 actgtggtgg gggtggcggg aggctttgat tttgcttatt ccctctgcca gttgcagtct
     1981 tttatttgag atggagtctc gctctgtcac ccaggctgga gtgcagtggc gtgatctcag
     2041 ctcactgcaa catctgcctc ccaggttcaa gcaattctcc tgcctgactc cactcccccc
     2101 aaacccccct caccgcccca gtatctggga ttacaggtga gcaacaccat gcccggctaa
     2161 tttttgtatt tttgatagag atggggtttt gccatattgg ccaggctggt cttgaactcc
     2221 tgacctcagg cgatcctccg actcggcctc caaagtcctg gattacaggc gtgagccacc
     2281 gcacctgccc aggtacactt ttatccagat atctatgcac attgattctt gactccacac
     2341 tcctgcctct ctccgcaagg ccttccctga cccccttgtt ttgaattgca atctgccctc
     2401 acataatccg tacgcctttt ctgtttaatt tttttcaacc gcacttttta ccctctcaca
     2461 ttctctagat ttggggcata ttacttgtct ccttccatca gaatgtaaac tccacgagat
     2521 taggagtgct gtcagctgtg ttcccttctc tgtcaatcgc cagcacctcc gaacagctcc
     2581 tggcacatag tagttgcttg gtaaatattt ctgcaatgca cgaggccgca tatgaccgga
     2641 atgggaggtg aggggattat tttctggcct ggaccagcga cggatggtgg tgccaccggg
     2701 ttggggagca cgtcggggat ggcgcgtaac gatgttagct ggggccaggt tgagctaggc
     2761 acgcaaatac aacttttttt ttcctggaaa ccctgtaaca ggaaggttcc ggagggcggg
     2821 acagcgtcgg aggcaggcag ctaggccatg ccaaatggca ctggggcttc gtgtcgtgcc
     2881 acaggcgtgg accgaaaatg cggacacatg caggctgcct ctcctcgcag gccagaagcc
     2941 acacgcagac ctagaccctt tgcaccgcat ccccttattc aatcgcgcac ccgccaccct
     3001 tcgacagttc ctctccctcc accccaaccc cacgccgcgc gcgaggctgg ccctttaaga
     3061 gccccgcccc gactccctcc cccctcgcgt gactgcgagc ccccgcgccg ggccggggaa
     3121 tgggtcggct gggtggctgc gcgggcctcc ggtccttctc acgcaacgcc tgggcaccgc
     3181 gcctccgggc caggtggggc ggggacgggc cgcctgacct ctgcccccta gagggatgtc
     3241 gccggcgcac gcaagctaga gccgggggta gggtgggggc tccgcgccag gtgccccctc
     3301 cgtggtccct gggcccgagt ctttccgtgg ccccccgccg ccggatttct gtgctctgcc
     3361 aatcaaagca ctagccaccc cgggagccaa gagggaccct caagggccgg tgggtcctgg
     3421 ctggagggac cgcgcgttgc aatcagcact aaggcgatcc tagaggctgc gaggagccgc
     3481 tagtgagcgc tcagcgagcc tgccccttcg ccatccattc cgatccttca atcaagaggc
     3541 gcgaacctca gctagtcgcc cgggctctgg gggacaggtc cagccccgcg gcgcctctgg
     3601 ccttccggcc ccgtgacctc agggctgggg tcgcagcgct tctcacgcga gccgggactc
     3661 agtaaccccg ggaaggaggt caccacgggg cagccccgcc cccgcctgcc gagtcctggt
     3721 aggctgtagc gctggggagg catctgcacg cccagcgttc cagtgggtgc aaaaatgacg
     3781 aagaggagtc cccgcgcccc aggatggagc ttcccgtacc ctctcttcgg gctgtcctgg
     3841 gacttctccc tcaagccccc tcctcggctg ggttctgcac tgcccttggg acgccttgga
     3901 attgggactt ccaggtgttc ccagccctca cccctctatg tacaggcacc gagatgtgtc
     3961 ccatagtggg ttcttgccca cccgaccccc cacccccgcc gccctccgcc acctttctct
     4021 ccaatcccag agagaccagc ccggttcagg ctgcttctcc ctccatctca gctcgctcca
     4081 gggaaggagg cgtggccaca cgtacaagcc cgcctataaa ggtggcagtg ccttcaccct
     4141 cacc
//