HDTenEightyP/NetNews huggingface dataset:
From: bill@nsma.arizona.edu (Bill Skaggs)
Newsgroups: alt.drugs,sci.psychology,talk.politics.drugs
Subject: Re: instant addiction?
Date: 24 Jul 92 04:12:32 GMT
	<BILL.92Jul21211819@ca3.nsma.arizona.edu>
	<1992Jul23.033826.17837@pony.Ingres.COM>
Organization: ARL Division of Neural Systems, Memory and Aging, University of
	Arizona


   Bill Skaggs writes:
   > Usually it requires dozens of exposures [to cause addition]
   > The controlling factor seems
   > to be the time delay between the behavior (i.e. taking a drug) and
   > activation of the brain's pleasure center (the neural pathway leading
   > from the ventral tegmental area of the midbrain to the nucleus
   > accumbens).  Crack cocaine causes very fast activation -- within a few
   > seconds -- and can sometimes lead to addiction in 3-4 exposures or
   > possibly even fewer.

   Jon Krueger writes:
   >Then if we administered crack with a variable time delay introduced
   >between the qualifying response and attainment of the CNS events you
   >specfify, it would be less addictive.  I'm unfamiliar with the
   >behavioral pharmacology literature here, who has performed this test?

Slight correction:  the prediction is that with a time delay the
addiction would take longer to develop, not that the addiction would
be any less strong.

Nobody has actually done this experiment, unfortunately.

A bit of background:  There is a pathway from the ventral tegmental
area (VTA) to the nucleus accumbens (NA) that uses dopamine as
neurotransmitter.  There is now a great deal of evidence linking this
pathway to reward, along four lines:  1) Animals given the
opportunity to self-stimulate the pathway do so at very high rates; 2)
Drugs that increase the amount of dopamine in the NA -- including
cocaine, amphetamine, and opiates -- are addictive; 3) behaviors that
are pleasurable -- including sex and eating tasty food -- lead to
increased activation of the pathway; 4) Drugs that antagonize dopamine
in the NA interfere with positive reinforcement learning.

Recently one group of researchers has attempted to create a
self-stimulation setup that would mimic the way drugs work.  In an
ordinary self-stimulation experiment, an animal presses a bar, and
immediately the VTA-NA pathway is stimulated, causing dopamine release
within milliseconds of the bar-press.  In contrast, when an animal
self-injects cocaine, the evoked dopamine release takes around 30 sec
to develop and lasts for several minutes.  In the new setup, when an
animal presses a bar, the VTA-NA pathway is not immediately
stimulated; instead it is stimulated repeatedly at low intensity with
a time-course matching that which would have occurred had the
bar-press caused an injection of cocaine.

The paper reporting this is "Modelling drug kinetics with brain
stimulation: dopamine antagonists increase self-stimulation", by M
Lepore and K B J Franklin, *Pharmacol Biochem Behav* 41:489-496
(1992). 

Unfortunately, they did not look at the effect of time course on
acquisition; their aim was to understand certain discrepancies between
the effects of dopamine antagonists on self-stimulation versus
self-injection of drugs.

	-- Bill
Newsgroups: alt.drugs
From: rcarter@nyx.cs.du.edu (Ron Carter)
Subject: Pot group can adopt highway (AP article)
X-Disclaimer: Nyx is a public access Unix system run by the University
	of Denver for the Denver community.  The University has neither
	control over nor responsibility for the opinions of users.
Organization: Nyx, Public Access Unix at U. of Denver Math/CS dept.
Distribution: usa
Date: Mon, 27 Jul 92 18:11:39 GMT


From a short AP article (26 JUL 92)...

State highway officials who barred the Ku Klux Klan from
a highway cleanup program said a group seeking to legalize
marijuana can participate.  The Arkansas chapter of the
National Organization for the Reform of Marijuana Laws, or
NORML, meets state criteria for the Adopt-a-Highway program.

The article also says that because NORML doesn't advocate
anything illegal makes it OK for the program.

--
Ron Carter |   Denver | Center for the Study of Creative Intelligence
  Director | Colorado | "A ... mind stretched by a new idea can never
rcarter@nyx.cs.du.edu | go back to its original dimensions."  -Holmes
From: canorml@igc.org (NORML California)
Newsgroups: alt.drugs
Subject: Re: Drug testing and life insurance
Date: 21 Jul 92 06:53:00 GMT
Nf-ID: #R:1992Jul16.031706.1589@ucsu.color:-199966714:cdp:1301300174:000:196
Nf-From: cdp.UUCP!canorml    Jul 20 23:53:00 1992


  Lots of life insurance companies are requiring urine testing for
applicants, despite the fact that there isn't an iota of statistical 
evidence that m.j. smokers have shorter life expectancies.
From: machman@milton.u.washington.edu (The Machman)
Newsgroups: alt.drugs
Subject: Re: Pot/being sterile
Date: 30 Jul 92 18:44:00 GMT
Organization: University of Washington

dc@ais.org (David Daniels) writes:

>Anyone out there have information on how long it takes for pot to make you
>sterile? (sp) If so could you please e-mail it to me.  Thanks, Dc

  forever.  see Dr. Lester Grinspoon's book "Marijuana reconsidered."

  Cambridge, Mass. : Harvard University Press [1977]
  NOTES: Includes index & bibliography.
  SUBJECTS: Marijuana. * Drug abuse. * Cannabis * Social Control, Formal
  LC CARD: 77076767 / ISBN: 0674548337. 0674548345

-- 
 /'''   The Machman     machman@milton.u.washington.edu    david c carroll
 c-OO                                                                      
    \                     "Big Science.  Hallelujah"
   -                                                                       
Newsgroups: alt.drugs
From: st1g9@elroy.uh.edu (Lee Preimesberger)
Subject: Re: lsd baseball rumor
News-Software: VAX/VMS VNEWS 1.41    
Organization: University of Houston
Date: Tue, 28 Jul 1992 02:38:00 GMT

In article <1992Jul27.223145.29992@ucsu.Colorado.EDU>, andersom@spot.Colorado.EDU (Marc Anderson) writes...
#I'm writing another paper for my psychology class on LSD, and was wondering
#if anyone has a reference to that claim that some baseball dude pitched
#a no-hitter on acid, or whatever.  (If no reference, at least a name to the
#baseball dude what be appreciated.)

	According to _Flashbacks_, Tim Leary and co. played a mean softball
game while high.  I don't think that he qualifies as a 'baseball dude' though.


			  Lee Preimesberger
st1g9@jetson.uh.edu ----- Undergraduate Scum ----- University of Houston, USA
      "They went around and around.  Nobody smiled.  They just went
              around and around." - _Breakfast of Champions_
                                --+--
	Public key removed in hopes of getting the Hell out of VMS.
From: ppennane@klaava.Helsinki.FI (Petrus Pennanen)
Newsgroups: alt.drugs
Subject: Re: MAO Inhibitors
Date: 30 Jul 92 07:10:13 GMT
Organization: University of Helsinki

In article <EeRifD600WB2A_l4k0@andrew.cmu.edu> af1x+@andrew.cmu.edu (Alan S. Ferrency) writes:
>I was wondering if anyone can tell me any drugs (or foods or plants 
>containins such drugs, I would prefer) that are MAO inhibitors. 

Harmine and harmaline are potent short-term MAO inhibitors found
in Peganum harmala (Syrian rue) seeds and Banisteriopsis caapi vine. The
combined concentration in P. harmala is 3%, in Banisteriopsis caapi
about one tenth of that if I remember correctly. I haven't found any
studies about the action of harmine/harmaline in humans, but 25-50 mg of
either should be enough to significantly inhibit MAO.
--
Petrus.Pennanen@helsinki.fi
From: joelong@romeo.caltech.edu (Long, Joseph Louis)
Newsgroups: alt.drugs
Subject: Re: Ketamine et al.
Keywords: ketamine fish-heads monkey-meat
Date: 23 Jul 92 06:22:00 GMT
Followup-To: alt.drugs
Organization: California Institute of Technology
News-Software: VAX/VMS VNEWS 1.41

In article <15423@ucdavis.ucdavis.edu>, fzjaffe@othello.ucdavis.edu (Rory Jaffe) writes...
>Anesthesiology is the only specialty in which respiratory arrest is
>desired.  Those drugs do a good job of inducing respiratory arrest.  If
>that's what you want, go ahead. (FOR THOSE OF YOU WHO CANNOT FIND THE
>SARCASM IN THAT LAST SENTENCE, read my lips: it's stupid to try those
>drugs!) 

Do "recreational" anesthetics (like Ketamine or N2O) induce respiratory
arrest?  My point is not all anesthetics were created equal... right?
If so maybe I'm dead and sending this message from 
joe@nitrous.heaven.org :-)

-joe (as seen on Ren & Stimpy)        "I've fallen and I can't get up."
Xref: sparky alt.drugs:13741 sci.psychology:3308 talk.politics.drugs:5435
From: jpk@Ingres.COM (Jon Krueger)
Newsgroups: alt.drugs,sci.psychology,talk.politics.drugs
Subject: Re: Partial Legalization
Date: 29 Jul 92 20:04:47 GMT
Reply-To: jpk@Ingres.COM (Jon Krueger)
Distribution: usa
Organization: Ingres Division, ASK Computer Systems.

Robert Cain writes:
> what say ye of the "it's the person" persuasion?

We attribute behavior to strange and untestable causes.

-- Jon

Jon Krueger  jpk@ingres.com  
Newsgroups: alt.drugs
From: morley@Apple.COM (John Morley)
Newsgroups: alt.drugs
Subject: Re: What is the Health Risk from Smoking MJ?
Summary: Get the facts straight!
Keywords: Smoking, Tobacco, Marijuana, Health
Date: 28 Jul 92 18:18:19 GMT
Organization: Apple Computer Inc., Cupertino, CA

In article <15868@pitt.UUCP>, geb@dsl.pitt.edu (gordon e. banks) writes:
> 
> I believe Bob Marley died from smoking so much ganga he got lung
> cancer.

Wrong!  Bob Marley died from a brain tumor, not lung cancer.  As for any
connection between the disease and his ganja use, I would tend to doubt it
because I'm sure that the propaganda pushers in Washington would have had a
field day with that if there was any way of establishing a connection.

- John

*******************************************************************************
* Std Disclaimer:   My opinions are mine.        |  Billboard seen next to a  *
*                   Apple's opinions are Apple's.|  cemetary said:            *
*                   Sometimes they are similar.  |  "If you were dead,        *
*                   Sometimes they are not.      |   you'd be home by now."   *
*******************************************************************************
From: sean@ms.uky.edu (Sean Casey)
Newsgroups: alt.drugs
Subject: Re: NORML at the Democratic Convention
Date: 21 Jul 92 08:21:23 GMT
Article-I.D.: ms.1992Jul21.082123.19867
Organization: The Leaning Tower of Patterson Office @ The Univ. of KY

:      Pot-Law Reform Group To Set Up Shop at Convention
:
:A group seeking marijuana-law reform says it will join "fellow marijuana
:smokers" Bill Clinton and Al Gore at the Democratic Party convention in
:New York.

I sure they don't want to legalize just marijuana. To be consistent,
one needs to make it all legal.

Sean
-- 
                  |``Wind, waves, etc. are breakdowns in the face of the
Sean Casey        | commitment to getting from here to there. But they are the
sean@s.ms.uky.edu | conditions for sailing -- not something to be gotten rid
U of KY, Lexington| of, but something to be danced with.''
Newsgroups: alt.drugs
From: s7356911@deimos.ucc.umass.edu (DYLYN)
Subject: Re: Canned shrooms?
News-Software: VAX/VMS VNEWS 1.41    
Organization: University of Massachusetts, Amherst
Date: Thu, 30 Jul 1992 16:45:00 GMT

Concerning easy extraction of goodies from shrooms:
...
>>>dried. Does anybody know whether canning the mushrooms would preserve more
>>>of the psilocybin and psilocin? 
>>
>>My guess would be that heat from canning breaks the psychoactive componants
>>down even more rapidly.  Fresh mushrooms should be kept in the refrigerator
>>in a ventillated container.  Dried ones can be frozen.
>>
>What about extracting the p &p from the fresh mushroom's?
>Is that even an option to the layman ?
>Matthew
		I've made simple cordials before (pick wild raspberries,
soak them in cheap vodka for two to three months).  This seems like a 
logical place to start:  try doing the same with the 'shrooms  (keep the
raspberries for taste, otherwise it'll taste like a snot cordial I'm sure :->)
	Actually, since we do have chemists on this group, we should probably
ask if this seems like it'll work.  I believe that the strong alcohol in 
vodka will dispatch most pathogens to a watery grave.  I don't have enough
of a background in chemistry to say if it will destroy the p & p or not, though.
					dylyn
_________---------__________-------------____________----------___________----
	"I hear they're dismembering people down the street--
		Those Joneses!  Ya gotta love `em!
	 Various disguises are regrettable but necessary,
		if you want to make it  through the day"
			--NoMeansNo, "Everyday I Start to Ooze"
 dylyn (aka, d prosser) == S7356911@UCSVAX.UCS.umass.edu
From: dit@sybase.com (David Trumbull)
Newsgroups: alt.drugs
Subject: Re: how much L. have folks done?
Date: 28 Jul 92 16:38:27 GMT
Organization: The Peanut Butter Conspiracy is spreading.

In article <lamontg.711057655@milton> lamontg@milton.u.washington.edu (Lamont Granquist) writes:
>bz206@cleveland.Freenet.Edu (Joseph Hack) writes:
>>hits from different areas of the same sheet of blotter can be of
>>different potency of the person doing the dipping is not careful to
>>distribute the stuff evenly.
>
>You can get a good idea of how even the stuff is layed down by looking
>at it under a black light.  LSD glows under UV.

Har.. This reminds me of my days as a skate-punk in Berkeley.. Quite frequently,
urchins could be seen running up the steps of the "Silver Ball Gardens" arcade
and rushing over to the TRON video game, which had a blacklight installed on
the front of it.. I wonder what they were doing.. ;-)
--
  Superhigh            \       Lookin for that good stuff... 
 dit@sybase.com        /        ...better tighten up on your backstroke. 
  Backstrokin'        /
From: 34AEJ7D@CMUVM.CSV.CMICH.EDU
Newsgroups: alt.drugs
Subject: SS harasses student for E-mail remark
Keywords: Bush SS Secret Service threat bust hassle harassment
Date: 29 Jul 92 14:57:20 GMT

|Subject: Article 9--Net Threat
|Message-ID: <1992Jun11.001601.29258@morrow.stanford.edu>
|Date: Thu, 11 Jun 1992 00:16:01 GMT
|
|Reprinted from the New York Times, 6/10/92 p. b8
|
|AN ANARCHIST, A THREAT TO BUSH AND THE SPOTLIGHT
|
|WILLIAMSTOWN, Mass., June 7 -- A computer message that threatened the
|life of President Bush has brought the Secret Service onto the
|tranquil Williams College campus here.  Under investigation for
|sending the message via the school's computer system is Brian Coan,
|an honors student and self-proclaimed anarchist who is also a track
|star at this small liberal arts college.  The two-sentence message,
|which was sent out in early May as part of a dialogue among students
|on a national intercollegiate network, condemned Mr. Bush for
|criticizing rioters in Los Angeles after he had waged war in Iraq.
|It then said, "George Bush and his people need a bullet in the head."
|It was not known how the authorities learned of the message, but Mr.
|Coan, who graduated today, said he was subpoenaed last month after
|refusing to talk with Secret Service agents who showed up at his
|track practice.  He said he appeared before a grand jury two weeks
|ago but refused to testify, citing his rights against compelled
|self-incrimination...
Newsgroups: alt.drugs,sci.med
From: billn@hpcvaac.cv.hp.com (bill nelson)
Subject: Re: Cancer risk of marijuana
Organization: Hewlett-Packard Company, Corvallis, Oregon USA
Date: Fri, 31 Jul 1992 18:57:19 GMT

DGS4@psuvm.psu.edu writes:
: In article <1992Jul31.165821.23454@hpcvaac.cv.hp.com>, billn@hpcvaac.cv.hp.com
: (bill nelson) says:
: >
: >: Despite the lack of direct evidence, I think it's safe to say that chronic
: >: marijuana use can cause serious health problems.  The lack of direct
: >: evidence is probably due more to the lack of chronic marijuana users,
: >: rather than the lack of a link between marijuana and health.
: >
: >: The above summary can be found in "Medical Underwriting" compiled by Richard
: >: Bailey.
: >
: >I suppose that the Rastians in Jamaica are classified as "casual and
: >occasional
: >users"? Right.

My comment was in regards to the statement about the "lack of chronic
marijuana users". It had nothing to do with you claim about health problems.

: Thanks for your sarcasm.  Now maybe you would care to offer some evidence
: (maybe a summary of a published article?) which shows that high use of
: marijuana among Jamaicans controlling for other factors, is not related
: to health problems.

See above.

Bill
Xref: sparky alt.drugs:13555 talk.politics.drugs:5351
From: stevea@bullyrag.ugcs.caltech.edu (Steven C. Anderson)
Newsgroups: alt.drugs,talk.politics.drugs
Subject: Carter and decrim (was: Re: Advertisement in the UK Times..)
Date: 27 Jul 92 00:47:32 GMT
Organization: Caltech Undergraduate Computer Science

In article <1992Jul25.190603.24961@ddsw1.mcs.com> zane@ddsw1.mcs.com (Sameer Parekh) writes:
>	The President doesn't make the laws.. Congress and the states make
>the laws. (The states make the state laws.) I think under Carter MANY states
>decriminalized marijuana.. (I am unsure on this tidbit-- anyone know for
>sure?)
>
>  _Sameer_Parekh_zane@ddsw1.MCS.COM_zane@infopls.chi.il.us__________________
> / STOP The War on Rights          | | Restore liberty in the United States \
> | "Specialization is for Insects" | | Vote Libertarian 1992          ______/
> \________- Robert A. Heinlein_____/ \_ap.2363@cupid.sai.com (anon)__/

Yes, I am sure it is true, but I am not sure of the name of the book that told
me.  It was a history of NORML in the 70's, a very good and interesting book.
It told when all the states entered decriminalization.
Look for NORML or marijuana law in a subject search, and you'll probably come
across it.  Anyone out there remember the title?
Carter came close to pushing for national reform in marijuana law, but the
political atmosphere around NORML got too hot for him.

-stevea@ugcs.caltech.edu	Steven Anderson
Newsgroups: alt.drugs,sci.psychology,talk.politics.drugs
From: jpk@Ingres.COM (Jon Krueger)
Subject: Re: Partial Legalization
Reply-To: jpk@Ingres.COM (Jon Krueger)
Organization: Ingres Division, ASK Computer Systems.
Distribution: sci.psychology
Date: 30 Jul 92 21:09:26 GMT

bill nelson writes:
> It is Nature's Desire that things go the way
> that Jon sees them.

That would be nice :-)

As it happens, you have it roughly backwords: it's my desire
to follow the facts.  But all I have contended here is that
the facts don't depend on your belief or mine.  Not much
controversy on that notion either.

> time to terminate this thread

Easily done.

-- Jon

Jon Krueger  jpk@ingres.com
From: klewis@mwunix (Keith Lewis)
Newsgroups: alt.drugs
Subject: Re: NORML at the Democratic Convention
Date: 21 Jul 92 13:36:59 GMT
Organization: Mitre Corporation, McLean VA

In article <1992Jul21.082123.19867@ms.uky.edu> sean@ms.uky.edu (Sean Casey) writes:
>:      Pot-Law Reform Group To Set Up Shop at Convention
>:
>:A group seeking marijuana-law reform says it will join "fellow marijuana
>:smokers" Bill Clinton and Al Gore at the Democratic Party convention in
>:New York.
>
>I sure they don't want to legalize just marijuana. To be consistent,
>one needs to make it all legal.

NORML has no position on drugs other than marijuana.

--
Keith Lewis              klewis@mwunix.mitre.org, klewis@mitre.org
Email me for my PGP key.
The above may not (yet) represent the views of my employer.
Xref: sparky alt.drugs:13598 sci.med:14583 talk.politics.drugs:5379 talk.politics.misc:36186
From: esr@snark.thyrsus.com (Eric S. Raymond)
Newsgroups: alt.drugs,sci.med,talk.politics.drugs,talk.politics.misc
Subject: Re: Definition of an addict.
Date: 27 Jul 92 15:48:40 GMT
Back-References: <26JUL199215113668@deimos.ucc.umass.edu>

In <1992Jul26.145826.15707@usenet.ins.cwru.edu> Dave Polewka wrote:
> An addict is someone who keeps getting into the same kinds
> of trouble, over and over again, even though he doesn't
> want to....but STILL thinks he's in control!

Ah.  In that case, it is both correct and predictive to observe that statists
are addicted to government.  Political-force junkies, unable to imagine any
solution beyond the next fix.  Poor bastards.
-- 
					Eric S. Raymond <esr@snark.thyrsus.com>
Xref: sparky alt.drugs:13770 sci.med:14816
From: dfavor@logan.tivoli.com (David Favor)
Newsgroups: alt.drugs,sci.med
Subject: Re: Ketamine et al.
Keywords: ketamine
Date: 29 Jul 92 11:47:25 GMT
Followup-To: alt.drugs

I'm curious if anyone knows of a country where Ketamine is available
over the counter?
From: mhergert@esk (Mark Ivan Hergert)
Newsgroups: alt.drugs
Subject: Re: LSD vs shrooms
Date: 28 Jul 92 02:16:40 GMT
Organization: University of Tasmania at Launceston

In article <9207230248.AA05345@wissel.stern.nyu.edu>, jmctigue@WISSEL.STERN.NYU.EDU (J C. McTigue) writes:
>
>
>My question:  What sort of experiences have people had with LSD vs shrooms?
>
>I have had LSD three times, and shrooms once.  For me, Acid was very
>intensly visual and caused my mind to race with ideas ( = alot of fun),
>while shrooms were very mellow and mostly made me feel just a bit odd
>(didn't seem anything special).  However, the shrooms were the first time I
>had tripped, and it is also possible that I did not have enough.  The
>quantitiy I ingested was "half an eighth."
>Is this a proper amount?  Do people have different types of trips with
>different types of mushrooms?
>
	I don't know much about the correct weights of mushrooms, because
i've only ever consumed fresh ones, but while theres a thread with 
mushies involved, does anyone know of any health problems realted to
long term use (or even short term) of Magic Mushies in general, specifically 
Psilocybe Zapectorem.  I've heard a rumour flying round that it is unsafe
to take more than three trips a year on them ( or any others), because of
the damage they cause to the Kidneys.  Any feedback? True, False, Yes, No
, Absurd, Precise, Fact, Fallacy?
	Also I read a breif reference on Panealus Sphinctrinus that 
stated that it's
use causes premature senility.  It also said that it and the sacred 
Teonanacatl, were on and the same. I thought the Teonanacatl was 
actually Stropharia Cubensis?
 
*_-=-_._-=-_._-=-_._-=-_._-=-_._-=-_._-=-_*####################################
:                                         :                                   #
: "When logic and proportion have fallen  : AARNET:                           #
:  far be dead, and the White Knight is   : mhergert@esk.compserv.utas.edu.au #
:  talking backwards and the Red Queen's  :                                   #
:  off her head...Remember what the       :     Psuedo Intellectual Hippie    #
:  doormouse said: Feed your head,        : of Radical and Chaotic Persuasion #
:                  Feed your head..."     :                                   #
:                                         :       UNIVERSITY OF TASMANIA      #
:          - Jefferson Airplane           :           - Launceston -          #
:                                         :                                   #
*_-=-_._-=-_._-=-_._-=-_._-=-_._-=-_._-=-_*####################################
Newsgroups: alt.drugs