From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human alpha-L-iduronidase gene, exons 1 and 2.
Date: 29 Dec 92 20:55:31 GMT
Distribution: bionet
Checksum: 17042 5

LOCUS       HUMALIDN01   1758 bp ds-DNA             PRI       11-DEC-1992
DEFINITION  Human alpha-L-iduronidase gene, exons 1 and 2.
ACCESSION   M95739
KEYWORDS    alpha-L-iduronidase.
SEGMENT     1 of 2
SOURCE      Homo sapiens (library: James Gusella's from Mass. General Hospital)
            DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Scott,H.S., Guo,X.-H., Hopwood,J.J. and Morris,C.P.
  TITLE     Structure and sequence of the human alpha-L-iduronidase gene
  JOURNAL   Genomics 13, 1311-1313 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            <583..740
                     /number=1
                     /function="cleavage of heparan and dermatan sulphate"
                     /EC_number="3.2.1.76"
                     /product="alpha-L-iduronidase"
                     /gene="IDUA"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     repeat_region   143..298
                     /function="unknown"
                     /rpt_family="Alu"
                     /rpt_type=dispersed
                     /rpt_unit=143..298
                     /standard_name="Alu repeat"
                     /citation=[1]
                     /note="putative"
     intron          741..1306
                     /number=1
                     /gene="IDUA"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     exon            1307..1447
                     /number=2
                     /function="cleavage of heparan and dermatan sulphate"
                     /EC_number="3.2.1.76"
                     /gene="IDUA"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
BASE COUNT      270 a    616 c    559 g    313 t
ORIGIN      
        1 ttaaatatgt atattcgtat tgctttggct taaacaatat ttcagtcctg ccttggttga
       61 atccatggat ctgaagccaa gtgtaaggag ggcccagtgt gctcttctgg ggtaattctc
      121 cttcctgcta aagcgcacgc tttactcagg aggctggggt gagaaaatcg ctgaagcccc
      181 ggagatggag gttgcagtga gctgagatcg cgccactgca cctcagcctg ggcgacaaag
      241 caagactctg tctcaaaaac acacaaaaac agagaaaaac aagacagtaa tggctcaact
      301 cacatagcac caacgggcga agcgttcttc tgagcgcttt ccgagtcatc ggtcctcaga
      361 gcagcccctg aggcccgcaa ggaagcgggg ctccaagccc tgccgtgctc ccggctcccc
      421 gaggctcccc gaggccaccc aacccctccc acccggccat cgccccctca ccaaggcccc
      481 gccccgcggc ggcggtcaca tggggtgcgc gcccagactc cgacccggag gcggaaccgg
      541 cagtgcagcc cgaagccccg cagtccccga gcacgcgtgg ccatgcgtcc cctgcgcccc
      601 cgcgccgcgc tgctggcgct cctggcctcg ctcctggccg cgcccccggt ggccccggcc
      661 gaggccccgc acctggtgca ggtggacgcg gcccgcgcgc tgtggcccct gcggcgcttc
      721 tggaggagca caggcttctg gtgagcgctc cgcggcctcc gggaccccct ggccgcacgg
      781 ggagagctcg ggcgccccct gactgcgcac tgtgagagct tcagagaccg gagctccctc
      841 ctctggggcc ctggctctcc cgggcccgcc ccccgccgtg tttgtgggtg ggtcctccac
      901 ctgagtgggc gccggggcgt gagcctgggc cgccccctgc agcccaggcc gatgcccggg
      961 atcctgctct ttgaggtaaa ccaggagtct cccctgggag tggacggccc tgcagcggga
     1021 cctggcctgc ctgtcccatt ccttccacct agagctgagg tacccgcctt cctggcaggg
     1081 ccagggccag ggctggcgtt ggcccctcgt cttactgctg ctgccgttcc ccatgaagat
     1141 gggacctccc cacattcctg gccctaaggg tcattttatt agtcactgaa cgcacgggca
     1201 gcgcctggat cctgcgcccg ggcagtcctg ggcttgaacg tgtgtgtcag ccgcgctgcc
     1261 agccatgctg aggctcggga ctgagccgcc cctttgttgt ccccagcccc ccgctgccac
     1321 acagccaggc tgaccagtac gtcctcagct gggaccagca gctcaacctc gcctatgtgg
     1381 gcgccgtccc tcaccgcggc atcaagcagg tccggaccca ctggctgctg gagcttgtca
     1441 ccaccaggtg ggcggcgggc agggtctggg cgtcccagag ccccttacag aggcacagat
     1501 gggaggggag ggctgggggc tgctcggaag accccttgtt cccccacctc ccgccgaagc
     1561 accctgttgg ggagagcgtg tccttgctgg ctgtgctggg gtgagggctg tgtgctggag
     1621 ggagcccctg catggggcac ggtgggcttc ctgcaggtct ccctgcaggc tcagggttgg
     1681 ctgcgccgca cctggctcct ggtcacccgt gagcatccct gtgtgtgtct gctggccagg
     1741 ctgggtaggg ccactgca
//