From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Canis lupus familiaris alpha-L-iduronidase (IDUA) gene, complete
Date: 4 Sep 92 10:02:50 GMT
Distribution: bionet
Checksum: 08949     4

LOCUS       DOGIDUAA     1128 bp ds-DNA             MAM       04-SEP-1992
DEFINITION  Canis lupus familiaris alpha-L-iduronidase (IDUA) gene, complete
            cds.
ACCESSION   L01065
KEYWORDS    alpha-L-iduronidase; glycosidase; lysosomal enzyme.
SOURCE      Canis familiaris testes DNA.
  ORGANISM  Canis familiaris
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Carnivora; Caniformia; Canoidea; Canidae.
REFERENCE   1  (bases 1 to 1128)
  AUTHORS   Menon,K.P., Tieu,P.T. and Neufeld,E.F.
  TITLE     Architecture of the canine IDUA gene and mutation underlying canine
            mucopolysaccharidosis I
  JOURNAL   Genomics (1992) In press
  STANDARD  full staff_entry
REFERENCE   2  (sites)
  AUTHORS   Stoltzfus,L.J., Sosa-Pindea,B., Moskowitz,S.M., Menon,K.P.,
            Dlott,M., Hooper,L., Teplow,D.B., Shull,R.M. and Neufeld,E.F.
  TITLE     cloning and characterization of cDNA encoding canine
            alpha-L-iduronidase: mRNA deficiency in mucopolysaccharidosis I dog
  JOURNAL   J. Biol. Chem. 267, 6570-6575 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             join(363..517,968..1108)
                     /EC_number="3.2.1.76"
                     /product="alpha-L-iduronidase"
                     /gene="IDUA"
                     /codon_start=1
                     /translation="MRPPGPRAPGLALLAALLAAPRALAEAPHLVLVDAARALRPLRP
                     FWRSTGFCPPLPHSQADRYDLSWDQQLNLAYVGAVPHGGIEQVRTHWLLELITA"
                     /partial
     exon            186..517
                     /number=1
                     /gene="IDUA"
     intron          518..967
                     /number=1
                     /gene="IDUA"
     exon            968..1108
                     /number=2
                     /gene="IDUA"
     intron          1109..>1128
                     /gene="IDUA"
BASE COUNT      125 a    515 c    371 g    117 t
ORIGIN
        1 aaaggccccg cccctccccg cggcccccgc ccccagagac cacccctcca caaaaggccc
       61 cgccccttcc ccgcccccac ggagccctgc ccctcgcctc gaggccacgc ccccgcaaca
      121 ggccccgccc ctccccgagg ccccgccccc agcgacaccc ccacaaggcc ccgcccccac
      181 gggccccgcc ccctcacccc gaggccccgc cccgccgctc cgcggcccca gaacccaccc
      241 acgtggtgtg cgacccggag gcggaaccgg ccggcgcggc gtagacccgg gctcccggag
      301 cgctgtgggg acgcgccccc cgcccccgcc cccgcccccg cgcccgcgac ccccgcccgg
      361 ccatgcggcc ccccggcccc cgcgcccccg ggctggcgct gctggccgcg ctgctggcgg
      421 cgccccgggc cctcgcagag gccccgcacc tggtgctcgt ggacgcggcc cgcgcgctgc
      481 ggcccctgcg gcccttctgg aggagcaccg gcttctggtg agggctccgc gggggaaact
      541 gaggcccgac aggcccggcc cgggttctgg ggccccgtgg cctgcgggag agccgcggcc
      601 ccgccctcgc ggctgcaccc gggcccgcgg gaggggcagg gcccgggacc gtccaggggc
      661 aggcgccgtg acctcggccg tcctggggtg accgcacccc accccccccc accccccccc
      721 caccccggcc ccagctgcgg ccccgcccag gggagaagga gcagggtgct gccggggggt
      781 gctcgcccct ccgagccccg gtcttccgta aacacgagac tccaccacag ccttcctgct
      841 cttggggtca ttttattccg gggaggaggg gggttggcag gcactgccgg gccgctgctg
      901 gagcctggcg tcctgggcct cccgggccgt cgggggcact aatgcccgcc ccctcgctct
      961 gccccagccc ccccctgccg cacagccagg ctgaccgcta tgacctcagc tgggaccagc
     1021 agctcaacct ggcctatgtg ggtgctgtcc ctcacggggg catcgagcag gtccggaccc
     1081 actggctgct ggagctcatc acggccaggt gagtggtggg cagctggg
//