From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human 17-beta-hydroxysteroid dehydrogenase (EDH17B1 and EDH17B2)
Date: 6 Nov 92 18:28:42 GMT
Distribution: bionet
Checksum: 27336 37

LOCUS       HUM17BHYD   21788 bp ds-DNA             PRI       02-NOV-1992
DEFINITION  Human 17-beta-hydroxysteroid dehydrogenase (EDH17B1 and EDH17B2)
            genes, complete coding regions and flanks.
ACCESSION   M84472
KEYWORDS    17-beta-hydroxysteroid dehydrogenase; Alu repeat;
            estradiol 17-beta-dehydrogenase.
SOURCE      Homo (library: Lambda EMBL13) DNA.
  ORGANISM  Homo
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Peltoketo,H., Isomaa,V., Maeentausta,O. and Vihko,R.
  TITLE     Complete amino acid sequence of human placental
            17-beta-hydroxysteroid dehydrogenase deduced from cDNA
  JOURNAL   FEBS Lett. 239, 73-77 (1988)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   The,V.L., Labrie,C., Zhao,H.F., Couet,J., Lachance,Y., Simard,J.,
            Leblanc,G. and Labrie,F.
  TITLE     Characterization of cDNAs for human estradiol 17 beta-dehydrogenase
            and assignment of the gene to chromosome 17: Evidence of two mRNA
            species with distinct 5'- termini in human placenta
  JOURNAL   Mol. Endocrinol. 3, 1301-1309 (1989)
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   The,V.L., Lachance,Y., Labrie,C., Zhao,H.F., Simard,J., Couet,J.,
            Leblanc,G. and Labrie,F.
  TITLE     Structure of two in tandem human 17 beta-hydroxysteroid
            dehydrogenase genes
  JOURNAL   Mol. Endocrinol. 4, 268-275 (1990)
  STANDARD  full automatic
REFERENCE   4  (bases 1 to 21788)
  AUTHORS   Peltoketo,H.E., Isomma,V. and Vihko,R.
  TITLE     Genomic organization and DNA sequences of human 17
            beta-hydroxysteroid dehydrogenase genes and flanking regions;
            localization of multiple alu sequences and putative cis-acting
            elements
  JOURNAL   Eur. J. Biochem. 209, 459-466 (1992)
  STANDARD  full automatic
COMMENT     [4] reports bases 6601-21788.
FEATURES             Location/Qualifiers
     mRNA            join(14023..15086,15180..15347,15495..15674,15850..15943,
                     16460..16637,16724..17268)
                     /gene="EDH17B2"
     repeat_region   907..21622
                     /rpt_family="Alu"
                     /rpt_type=dispersed
                     /rpt_unit=10904..11038
                     /rpt_unit=11417..11674
                     /rpt_unit=13232..13514
                     /rpt_unit=13544..13818
                     /rpt_unit=13835..18937
                     /rpt_unit=13938..14073
                     /rpt_unit=17126..17260
                     /rpt_unit=17636..17897
                     /rpt_unit=1898..2178
                     /rpt_unit=19461..19739
                     /rpt_unit=19755..20038
                     /rpt_unit=20086..20280
                     /rpt_unit=20297..20570
                     /rpt_unit=20571..20849
                     /rpt_unit=21100..21300
                     /rpt_unit=21332..21622
                     /rpt_unit=2481..2760
                     /rpt_unit=3984..4128
                     /rpt_unit=4146..4428
                     /rpt_unit=4429..4562
                     /rpt_unit=4577..4858
                     /rpt_unit=6655..6809
                     /rpt_unit=6816..7097
                     /rpt_unit=7569..7888
                     /rpt_unit=907..1187
     repeat_unit     907..1187
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     1898..2178
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     2481..2760
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     complement(3984..4128)
                     /rpt_family="Alu"
                     /rpt_type=inverted
                     /note="right arm"
     repeat_unit     complement(4146..4428)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     repeat_unit     complement(4429..4562)
                     /rpt_family="Alu"
                     /rpt_type=inverted
                     /note="left arm"
     repeat_unit     complement(4577..4858)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     repeat_unit     complement(6655..6809)
                     /rpt_family="Alu"
                     /rpt_type=inverted
                     /note="right arm"
     repeat_unit     complement(6816..7097)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     repeat_unit     complement(7569..7888)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     repeat_region   7754..20180
                     /rpt_type=direct
                     /rpt_type=tandem
                     /rpt_unit=13938..20180
                     /rpt_unit=7754..13937
                     /note="duplicated regions D1 and D2"
     repeat_unit     7754..13937
                     /gene="EDH17B1"
     misc_difference 7826..7829
                     /note="present in clone lambda17-HSD5; absent in clone
                     lambda17-HSD3"
     misc_difference 7833..7839
                     /note="present in clone lambda17-HSD5; absent in clone
                     lambda17-HSD3"
     prim_transcript 7840..11038
                     /gene="EDH17B1"
     misc_difference 8119
                     /note="G in clone lambda17-HSD5; A in clone lambda17-HSD3"
                     /gene="EDH17B1"
     misc_difference 8202
                     /note="C in clone lambda17-HSD5; T in clone lambda17-HSD3"
                     /gene="EDH17B1"
     repeat_unit     10904..11038
                     /rpt_family="Alu"
                     /rpt_type=direct
                     /note="left arm"
     repeat_unit     complement(11417..11674)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     misc_difference 12291
                     /note="C in clone lambda17-HSD5; T in clone lambda17-HSD3"
     repeat_unit     13232..13514
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     13544..13818
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     13835..13937
                     /rpt_family="Alu"
                     /rpt_type=direct
                     /note="truncated"
     repeat_unit     13938..20180
                     /gene="EDH17B2"
     repeat_unit     complement(13938..14073)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     prim_transcript 14023..17268
                     /gene="EDH17B2"
     exon            14023..15086
                     /number=1
                     /gene="EDH17B2"
     CAAT_signal     complement(14889..14892)
                     /gene="EDH17B2"
     protein_bind    14921..14922
                     /bound_moiety="transcription factor AP-2"
                     /gene="EDH17B2"
     GC_signal       14926..14939
                     /gene="EDH17B2"
     TATA_signal     14949..14955
                     /gene="EDH17B2"
     intron          15087..15179
                     /number=1
                     /gene="EDH17B2"
     exon            15180..15347
                     /number=2
                     /gene="EDH17B2"
     intron          15348..15494
                     /number=2
                     /gene="EDH17B2"
     exon            15495..15674
                     /number=3
                     /gene="EDH17B2"
     intron          15675..15849
                     /number=3
                     /gene="EDH17B2"
     exon            15850..15943
                     /number=4
                     /gene="EDH17B2"
     intron          15944..16459
                     /number=4
                     /gene="EDH17B2"
     exon            16460..16637
                     /number=5
                     /gene="EDH17B2"
     intron          16638..16723
                     /number=5
                     /gene="EDH17B2"
     exon            16724..17268
                     /number=6
                     /gene="EDH17B2"
     repeat_unit     17126..17260
                     /rpt_family="Alu"
                     /rpt_type=direct
                     /note="left arm"
     repeat_unit     complement(17636..17897)
                     /rpt_family="Alu"
                     /rpt_type=inverted
     repeat_unit     19461..19739
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     19755..20038
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     20086..20280
                     /rpt_family="Alu"
                     /rpt_type=direct
                     /note="truncated"
     repeat_unit     20297..20570
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     20571..20849
                     /rpt_family="Alu"
                     /rpt_type=direct
     repeat_unit     complement(21100..21300)
                     /rpt_family="Alu"
                     /rpt_type=inverted
                     /note="truncated"
     repeat_unit     21332..21622
                     /rpt_family="Alu"
                     /rpt_type=direct
     CDS             join(14990..15086,15180..15347,15495..15674,15850..15943,
                     16460..16637,16724..16993)
                     /EC_number="1.1.1.62"
                     /standard_name="estradiol 17-beta-dehydrogenase"
                     /product="17-beta-hydroxysteroid dehydrogenase"
                     /codon_start=1
                     /translation="MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQG
                     RLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEA
                     LGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASK
                     FALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQ
                     YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNY
                     VTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRSAVGDPELGDPPAAPQ"
BASE COUNT     4889 a   5920 c   6091 g   4888 t
ORIGIN      
        1 gtcgacctgc aggtcaacgg atccaactca tgggcagctc tagatctgcc tccctggaag
       61 cttctgtgct gcaatggctg ctccaggctc tgcttaagct cttcacacag ttgccctgcc
      121 cttccatctg gcactcttgc tccatgaagc cttctaaggc cttcctcttg ggggaaagcc
      181 cctttgtgcc ccatctcctc acccatgcga caaaggcaac acagtgaact cacctactca
      241 caggtctctt tcctctgggc tgtgggctcc ttgatggcag cgttcggatt ttgtctcagt
      301 agccctagcg cccagcacaa agaagcaatg agtgaatggt tgttgaatga atgaatgaat
      361 gaatgaagat gaatatattt ctatgtgtgg gcccttcttc ctcaggtgta cctggccttg
      421 ggcctgaccc aggcagagat caatgagttc tttactggtc ctgccttcct ggcctggggg
      481 cgaatgggca acctgcacac ctgggatggc cccctgcccc cctcctggca catcaagcag
      541 ctttacctgc aggtaaaagg atggaaaagg gaaggggcag aatcggtgat agatggtcat
      601 gggcccagga agggtggtat taggccggcc ccagggctct taactgaggc ggggggctgc
      661 gtgtatcctg ggagatgagg gccttctcat aggacagcag tggccatgct caccaccctt
      721 ccttctgttc ctccagcacc gggtcctgga ccagatgcgc tccttcggca tgaccccagt
      781 gctgcctgca ttcgcggggc atgttcccga ggctgtcacc aggtgaggtt ccgctcaccc
      841 cctccactta gctcagagag ggaattttat tcccttctag aacatgactt aaaaacttaa
      901 gctctgggcc gggcgcagtg gctcacgcct gtaatcccag cactttggga ggccgagttg
      961 ggcggatcac ctgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccctgtc
     1021 tctactaaaa atataaaaat tagctgggca tggtggcacg cgcctgtaat cccatctact
     1081 taggaggctg agacaggaga attgcttaaa cctgggaggc agacgttgca gtgagtcaag
     1141 atcacgccat tgcactccag cctgggtgac gagcgaaact ctgtctcaaa caaacaaaca
     1201 agctctggac gtaggcctgg gtttgatttc tgactctgct actaattagc tgtgtgactt
     1261 cgggcagatg acatgactgc tctgtgcctc agtttcctta cttgtaaaat gggatctcta
     1321 cccactcgct gtagggtttg taattatctc tcgatctatc tgtgactttg cacagagtgc
     1381 tagcaaatgg cagcccctgg gagtggccgc aggggtgctc cagtgtccct tgtcccttcc
     1441 tgttcctcgg gctttcccag ccatcctgta aatgtcttgg gaaaagtctt caaggctcac
     1501 ctgagacctc ccctccttca ggaagccttg ctagtgcccc gcatgacctc ctttgcacct
     1561 gctaatgtct ggctcccata ctctcgtagg acttaatgca tgccagtggc ctccctgccc
     1621 gcctctttgc ccccatcacc aggtggcagg aaactcactc attcattcaa taaacttggt
     1681 ccagctgtct gaggctgcca gaactggctg tgctgggtcc tgggaggcgg caagaaaggt
     1741 gcccaagggc ttacccctga taggagagat atgttggctg aaggatacaa tgtggggaca
     1801 aggacaggaa tatatgtggg ttccgctctc ctctgccggg agagaggggc aggaagggct
     1861 cagggcagag cccagccttg aaaaatgagt gttgcttgga cggacgcttg gctaatgctt
     1921 gtaatcctag cgttttggga ggctgaggcg tatggatcac ctgcggtcag gagttaaaga
     1981 ccagcctggc caacatggcg aaaccccatc tctactaaaa gtacaaaaat tagccaggcg
     2041 tggtggcggg ctcctgtaat cccagctact cggtaggctg aggcatgaga atctcttgaa
     2101 gccaggggcc agagactgca gtgagccgag atcacaccac ttcactccag cctgggtgac
     2161 agagtgagac tccgtctcaa aaaaaaaaaa aaaaaaagga aagaaaatta aacacctcat
     2221 gttctcactc atagtgggag ttgaacaatg agaacaacat ggacacagga aggggaacat
     2281 cacacaccgg ggcctttcgc ggtgtggggg tcaaggggag gagtagcatt gggacagata
     2341 cttaatgcat gcggggctga aaacctagat gatgggttga tgggtgcagc aaaccaccat
     2401 ggcacatgta tacctatgca acaaacctgc atgttctgca cagaactgaa ctgaaagtat
     2461 aattaaaaaa aaaaaaaaaa gctgggtgcg gtggcccaca cctgtaatcc cagcactttg
     2521 ggaggccgag acgggcggat cacaaggtca gcagatcgag accatcctgg ctaacacagt
     2581 gaaactcagt ctctactaaa aatacaaaaa attagccggg tgtggtggcg ggcacctgta
     2641 gtcccagcta ctagggaggc tgaggcagga gaatggcatg aacctgggag gcagagcttg
     2701 cagtgagctg agaatgcgcc actgcactcc agcctggggg acagagtgag actctgcctc
     2761 aaaaaaaaaa aaaaaaagaa agaaaaagga gcgttgcttg tttcaggcca caggaagggg
     2821 agagatagtg aaagtttttc agagaaggtg gccagggaag gagaagaaag gactgtaggc
     2881 agagagcata gcctgtacaa agccatagag gcaagagaaa ccaggagctg tagagaagtt
     2941 ggcaaggctg ttgaacacta tggtgaacac tatggcggct tccatgaaat atctgagctt
     3001 ttgctcccca ctagggtgtt ccctcaggtc aatgtcacga agatgggcag ttggggccac
     3061 tttaactgtt cctactcctg ctccttcctt ctggctccgg aagaccccat attccccatc
     3121 atcgggagcc tcttcctgcg agagctgatc aaagagtttg gcacagacca catctatggg
     3181 gccgacactt tcaatgagat gcagccacct tcctcagagc cctcctacct tgccgcagcc
     3241 accactgccg tctatgaggc catgactgca ggtacagtgc ctgggtgggg tgggagagcc
     3301 ccccagaccc tcaaaaagaa gggagtagca gatgtcagta ggggtaggca gagggactgg
     3361 aataatgcct cgccataaca cacagtactt tatagtttac caagcacgtg tacacatgcg
     3421 ttgtctcagt gaatcccact gtggttgaga ggtgagctct ggaagccaac aacctgggtc
     3481 acacctcgcg ctcctatttc ctggccgtgt gacttatgac tcatgacctc cttcccagtg
     3541 tctcgtttgc ttttcctgta aactgggact acctcatagg tagaataacg cctggcccag
     3601 agcaaaggcc actaagagct agctatgaac aaggattttg tttcatctct gcgtggttgc
     3661 tgaagtaggc actgcaggca ggaggtgagt ggatgtgcct aaaggcacta agtgcgcatc
     3721 ctgctacaaa actgtgaagc cagggctcct tcctgccact taaaggagga gtggagcaga
     3781 gggcgcccaa gtcaggaatg acttagtgga gaggcgtctg tgttggccag gaagggaaca
     3841 gatcagctca gcctttcttg agcagtactg ctccaagtgt gacccaaaac cagcagcagc
     3901 agcagcagca gcccgagctg tgagatggca aattctcagg ccctacccaa gacctgaagg
     3961 agaagctaca tttttttttt tttgaagaca gatttcactc tgttgctgag gctggagcac
     4021 agtggcacaa tctcatctca ctgcaacctt cgtctcctag gttcaagcga ttctcctgcc
     4081 tcagcctccc gagtagctgg gactataggc acccgccacc acgcccggca atttttgttt
     4141 gttttgagat agagtctcgc tctgtcaccc aggctggagt gcagtggcac gatctcagtt
     4201 cactgcaacc tctgcttcct gagttcaagc gattctcctg cctcagcctc ctgagtagct
     4261 gggattacag gcgcccccca accacactcg gctaattttt gtatttttag tagagacggg
     4321 gtttcgctat gtaggtcaag ctggtttcaa actcctgacc tcaaatgatt cgcccacttc
     4381 agcctcccaa agtgctggga ttacaggtgt gagccacctt gcctggccaa tttttgtatt
     4441 tttagtagaa acaggtttca ccatggtggc cagactggtc tcaaactcct gacctcaggt
     4501 gaactgccca cctcagcctc ccaaagtact ggtattacag gcgtgatcca ctgcgactgg
     4561 ccttgatttt gtttttgaga cagaatctta ctctgtcgcc cagactggag tgcagtggca
     4621 caatctcagc tcactgcaac ttctgcctca tgggttcaag tgattcttgt gcctctacct
     4681 cccgagtagc cgggattaca ggcacctgcc attacgctag gctaattttt gtatttttag
     4741 tatagacagg gtttccccac attggccagg ctggtctgga actcctgggc tcaagtgatc
     4801 cacctgcttc agcccctcag agtactggga ttataggtgt gggccaccac gcccattcag
     4861 aaacctccat gttttaagga gcctctgggt aactctcatg ttcacccaag ctgctgaacc
     4921 ctgtcttgga gttttcagag ggacgcgtat gtgccacaga cgtcccgctg gtgggggtca
     4981 tgggaagcca tgacctggga tagacagtcg tctgtagagt ggggtgaaca ttccctgggc
     5041 cctctgtttc atcactcctc ttctctgttc cccctacctc ctgtccacag tggatactga
     5101 ggctgtgtgg ctgctccaag gctggctctt ccagcaccag ccgcagttct gggggcccgc
     5161 ccagatcagg gctgtgctgg gagctgtgcc ccgtggccgc ctcctggttc tggacctgtt
     5221 tgctgagagc cagcctgtgt atacccgcac tgcctccttc cagggccagc ccttcatctg
     5281 gtgcatgctg cacaactttg ggggaaacca tggtcttttt ggagccctag aggctgtgaa
     5341 cggaggccca gaagctgccc gcctcttccc caactccacc atggtaggca cgggcatggc
     5401 ccccgagggc atcagccaga acgaagtggt ctattccctc atggctgagc tgggctggcg
     5461 aaaggaccca gtgccagatt tggcagcctg ggtgaccagc tttgccgccc ggcggtatgg
     5521 ggtctcccac ccggacgcag gggcagcgtg gaggctactg ctccggagtg tgtacaactg
     5581 ctccggggag gcctgcaggg gccacaatcg tagcccgctg gtcaggcggc cgtccctaca
     5641 gatgaatacc agcatctggt acaaccgatc tgatgtgttt gaggcctggc ggctgctgct
     5701 cacatctgct ccctccctgg ccaccagccc cgccttccgc tacgacctgc tggacctcac
     5761 tcggcaggca gtgcaggagc tggtcagctt gtactatgag gaggcaagaa gcgcctacct
     5821 gagcaaggag ctggcctccc tgttgagggc tggaggcgtc ctggcctatg agctgctgcc
     5881 ggcactggac gaggtgctgg ctagtgacag ccgcttcttg ctgggcagct ggctagagca
     5941 ggcccgagca gcgcagtcag tgaggccgag gccgatttct acgagcagaa cagccgctac
     6001 cagctgacct tgtgggggcc agaaggcaac atcctggact atgccaacaa gcagctggcg
     6061 gggttggtgg ccaactacta cacccctcgc tggcggcttt tcctggaggc gctggttgac
     6121 agtgtggccc agggcatccc tttccaacag caccagtttg acaaaaatgt cttccaactg
     6181 gagcaggcct tcgttctcag caagcagagg taccccagcc agccgcgagg agacactgtg
     6241 gacctggcca agaagatctt cctcaaatat taccccggct gggtggccgg ctcttggtga
     6301 tagattcgcc accactgggc cttgttttcc gctaattcca gggcagattc cagggcccag
     6361 agctggacag acatcacagg ataacccagg cctgggagga ggccccacgg cctgctggtg
     6421 gggtctgacc tggggggatt ggagggaaat gacctgccct ccaccaccac ccaaagtgtg
     6481 ggattaaagt actgttttct ttccacttaa actgatgagt cccctgggtc tgtcaaaatg
     6541 agaaggtcac tgctgccacg cttgggagga ctcagggcta tagcatggcc ctggggtggg
     6601 acctgttctc ccatcccttg cctcacgtcc ctgtttttgt ttgtttgttt gtttgtgacg
     6661 gagccttggt ctgttgccca ggcttgagta caatggcaca gtctcggctc actgcaacct
     6721 ccgcctcctg ggttcaagca attcttgtgc ctcagcctcc ccggtagctg ggactatagg
     6781 catgcaccac cacaccaggc taattttttt tttccaagat ggagtcttgc tctgtcgccc
     6841 aggttggagt ttagtggcac catattggtt tactgcaacc tctgcctccc gggttcaagc
     6901 aattctcctg cctcagtcta ccagggagtt aggactacgg gcctgtgcca tcacgcctgg
     6961 ctaatttttg tatttttcat agagataagg tttcaccatg ttggccaggc tggtctttaa
     7021 ctcctgaact caagtgatcc acctgcctcg gccttccaaa gtgctgggat tacaggagtg
     7081 agccaccgtg cccggccatg tctctctttt taacactaat gttaccctga cctttgaacg
     7141 tagaatgccc ttctgttgca ggaaaacctc ttttcaaacc atgtttgtcc tttgctggca
     7201 tgccacagca acagtcacca acacagaaga cttctgtgac caaatatttg gaggattttc
     7261 cccacacaca ccaagcagca gacatcagct gggtgtcctc caattcagtt ccaatgtaat
     7321 caaccagaga cagcatcaga tcccacaggg ttagggtgca gatccatgag accaccccct
     7381 ccttcccaac ggttacaagt cctgatccct ggaacttctg actaactggc ttcaagttgg
     7441 agttcccatg acccccttcc cctctttgga gtcaactcat ttgcgacagt gacccacgaa
     7501 acacagggaa acccttatta tgtttattgc tttattacag aggaaaaaaa tttttttctt
     7561 tcttttttga gacagggtct cactctgtca tccagaatga ctgcagtggc aggatctggc
     7621 tccgtcaccc aggctggagt gcagtggcat gatctcggct cactacagcc tccatccccc
     7681 ccaaacccca cgcctcagcg ccccaccccg caagtggctg ggactctaag catacaccac
     7741 cacacccagc taattttttt gtagtttttg caaagacggg gtctcattct gttgccctgg
     7801 ctggtcttga actcctgagc tccagcaatc cccttgtctt ggcctcccaa agtgctggga
     7861 ttacaggcat cagccaccgt gcccaacctc aaaggatatt ttaaaggata gaaataaaca
     7921 gccatatgaa gagatacaga cagggcggtc tggaagggcc cagagcagga gcttctatct
     7981 ccatagagtt ggggttacat caccctccag gcacatggat gagttcttca ccttctgtca
     8041 gcctccacac gttcagctct cagaagcttc ccgaaccctg tcctttgggc cttttatgga
     8101 gaactccatt ggctgtccgt gactgaagca tggacaactg tgataatgtg attgggcaaa
     8161 aagggtctga tctaagccca gcaaggccag tccagattct tcgggccttt gtgcagcatt
     8221 cctttctcca gggtatgggg caaggaccca ctctggaatg aggatcctac aacccacaat
     8281 cagattagag tcctgccttg ggcagctgaa aagaggacag gagaaggtca aagagaggaa
     8341 aggctgtttt ttgaggcctg aggcgcccca acatgacaac gaaagactgt aaccatggtc
     8401 atgtgagtta tgagctagga accctggacg aaaccaacac atatacaatc atctcccacc
     8461 tcccaacacc tttactttca cagcctctgc agcaaactgc ggtcactata atcgctcctg
     8521 tggcacagag gcatacccag gggaatctgc ccagggggcc actctgtgcc cacatgggaa
     8581 cccacatctg cttgtaaagc ctcccctccc tctgaccaga aacgaggaca gtttgttgtt
     8641 ccaagcagtg ggctcatgtc tgttttggct cagaacaggg tggggagagc gggccaggga
     8701 cccgaggagg gcttatcctt gagattgcgt gggagacaca acaaggggtg ggggcccgca
     8761 ggcggggcgg ggcgaagcag gtgatatcca gcccagagcc ccagcctctc cccacagtct
     8821 caccatggcc tgcaccgtgg tgctcatcac cggctgttcc tcaggtattg gcctgcactt
     8881 ggcaatacat ctggctttgg acccatccca gagcttcaaa ggtatagata ggtagggaca
     8941 gggagggaga gaagggaaaa gcccttggag gccagaagag aagtcagatc ttcctcctct
     9001 cccaaaacct ccagtgtatg ccacgttgag ggacctgaaa acacagggcc ggctgtggga
     9061 ggcggcccgg gccctggcat gccctcaggg atccctggag aggttgcagc tggatgtaag
     9121 gaactcaagc tccctggccg ctgcccggga acgcgtgacc gagggccgtg tggatgtgct
     9181 gggtgagcct cctggaagca tatgggctcc taggagcctt ctccgccctg cgttgaaacc
     9241 aacatgtccc caggcccctg gagcatgagg ggacaggccg tgctgagggt gatgctgagg
     9301 cgggctggtt gggcctctgt ccccgcagtg tgtaacacag gcctgggcct gctggggccg
     9361 ctgggggagg acgccgtggc ctctgtactg gatgtgaatg tagtaggtac tgtgcgggtg
     9421 ctgcaggact tcctgccaga catgaagcgg ccgggttcgg gacgcgtgtt ggtgactggg
     9481 agcatgggag gattgatggg tgagtggcag ggaccgggcc ccggagctcc agattctttg
     9541 tgtgcagagc tgagccttga aggcaggctc cttagggggt ggggtgcaat cagcttggag
     9601 gggcactgcc tgccggggga tgaccccctg gccgctgcgc ctcaggaacc tcatcttccc
     9661 acccaagggc tgcctttcaa tgacgtttat tgcgccagca agttcgcgct cgaaggctta
     9721 tgcgagagtc tggcggttct gctgctgccc tttggggtcc agtgagtcaa cacccccgtc
     9781 tcctcaaccc tcttaactct gacctagaga tgccgagcac cctgtcctgc ggaagccgct
     9841 ctggtctctg cccggcttac atttgctgcg tgccaggcac ttaggctgga gcattggcac
     9901 gcattgtgcc acttgctgac ctggctgctg aagtgttggt attgttatgg ggaagctcca
     9961 gccaggagag gttaggtgac tggcccaagg tcatgcagcg gccggggatc ccgccaggtt
    10021 cgaattctga caccagggct acctggcagc ctcagatggg tttgggaggg ctgtcgagca
    10081 ataacccgct attcaaatgt tctggttatc cccagcgctc tttccacctt cgggacgcag
    10141 cggtgctgtt ctgggtcgtg gccagggccg gggtcggggc cggtgctggg gcaggagatg
    10201 ggacttggcg cctggtcgct ccgtccctgc ccacttgcgg ctctcgggcc agcagcgtga
    10261 gcctgatcga gtgcggccct gtggacaccg ccttcatgca gaaggtgttg ggcggtcccg
    10321 accaggtgat ggaccgcacg aacacccgga ccttccgcct cttgcactaa tacctccacc
    10381 acagcaagga gatctaccgc gaggaggcgc agcaccctga ggaggtggtg aaggtgagcg
    10441 gggggcggga ctccgggagc gggggcggtg cgtcgtcctg cgcgcagccg gggccagagc
    10501 tcctctcccg ccgccgcagg tcttcctcac cgctatgcgc gccccgaagc cgaccctgcg
    10561 ctacttcaca accaggcgct tcctgcacca gctgctgatg cgcctggacg acccctttgg
    10621 cttcgactac gccgccgcca tgcaccggga cgtgttcgcc gacgatcccg cagaggccga
    10681 ggctggggcc ggggctgggg ccgaggccgg gggcggggcc ggtgggatgg gagaccctga
    10741 gctcagcgat cctctggccg ccccgcaaga aaggctccgt cagccactgt ctcccgcgcc
    10801 ctcctttgtc tcctgggcct gtgcggtccc tggggatggg acggcggtga cggctgtgga
    10861 tggctaatta agacagatca cgttagcccg ttatatctgc gcggctaggc gcgatggctg
    10921 tcgcctataa tcccagagct ttggaaggcc gaggcaggag gatcgctcca ggccaggagt
    10981 tccagaccag cctgagcaac atagtgagac accccatctc taaaataaaa aaattagcac
    11041 agtggcacca ttccttgagc tcaggagttg gaggctgcag tgggcatgat cgagctactg
    11101 ctctccagct tgggtgatag agtgagacac tgtcaattaa ttaatctaat caaccaacca
    11161 acccaacaac ccagaaacca aggtccagaa agaagccagc ccaggatcat gcctcaagtc
    11221 cacagtaaag cccagacaca gtcactggat acccaagggg catctgcagg acgagttagg
    11281 tgggacttgg gttggggtag agtcaggttg tgacctgcac tccattagcc atgagacctc
    11341 aggcaagttc cttgctttct ctgagtgctt tcctttcctt tcccttttct tttctttttt
    11401 gtttttcttt tgttttgaga tggagtttca ctcttgttgc ccagcctgga gtgcaatagc
    11461 gcggtctcag ttcaccacaa cctctgcctc ccgggttcaa gtgtagctag gattgcaggc
    11521 atgtgccacc acgcccagct aattttgtgt ttttagtaga gacgaggttt ctccatgttg
    11581 gtcagactgg tcttggactc ccgacctcag gtgatccgcc cgccctggcc tctcagagtg
    11641 ctgggattac aggcatgacc caccccatcc ggccctctga gtctttctta tctgtaaaat
    11701 gggtataata atacctatct aatcggtttt agtaatggtg gagataatgc ctgaaagtgc
    11761 tagtatagag gtttaatagc cagcaaggac tgttattaga atgaatagta atatgactac
    11821 tgtcacattt tgcaaatgtg taaagaagaa agagggctaa gtgaatcaaa gggagacagc
    11881 cccactcacc ctgttctgcc ccagaggact gagcgatccc caccatctgg caagctgcct
    11941 caccaggagg tccagctggg gctacaggac tggctacttt gctacaatgg cccgtctttc
    12001 ctgagcccag tggagggtcc caggggggca gaagtcattg ataggggcca gtagggttgt
    12061 agagccactg tctgaacttc tgtggaggtc tggtgcaggg gaggtgtgaa cagataggag
    12121 gctaggtgag gatgcagcag aggaagggca ggagtccgca ggagggggcg gtaccgaggc
    12181 agggattcag ctgggtctga gagggaggca aggctgaggg ggatggccct ttggagtggg
    12241 cagggacatg accacagaaa gcctgggaag tggaaacaga caggagcctg ctggagctct
    12301 tggagctttg tgtggggcac taggggaagg aggcaggcac tccaccctga cctgccccta
    12361 cctctggatg agggtcttct ctgcctgttg gatgatgtgc tgcccctgct cttggaggaa
    12421 gaggcctccc agccaccccc tcctgccagt cgccttgccc tgctgaccca gacagatctg
    12481 ctatccctac agcatccagg aaggccacag ggagggggcc caggtggcat gggtttctga
    12541 ggcctgggat ctgctctcag tcccgctctc gccaaccccc tttgcccctc tgtgacagtg
    12601 tgtgtacata tgcgtgcatg tgtgtacctg tgtggtgtgg ctcacaaggt cacccctggg
    12661 ggtgggataa taagaggtaa agtgtgaccc cctctcttcc gtacattcat tttttcaagc
    12721 ttgtgaatat tcacattgtt aatataatct tctgcagtcc catgacttcg aatagcactt
    12781 agatgccgat gaccccccca ccaaagaaac cccactgtct cccacagact ccaggtctgt
    12841 atctccaact gcctactcaa tacaacacgt ccacctgatg caatgaactt aatgtgtcta
    12901 aaccccaatt ccacatttcc agtcctccta ccggctcctc ccccagtctt ctctacttta
    12961 ctgtatgaca actccatttt tcccaatact ggttttaaaa accctggagt agtccttgac
    13021 tccagtctct ctcacctttc aaccaattca gcagcaaata ctgacagctc tacctttgct
    13081 catcaaagca tatccccaaa tcaccctatt ccagactgca cactgtcatc tctcccttca
    13141 attacagcag tagcctccta actagttttc ttgattccac tcttgcccat cagcagtgaa
    13201 attaccccag agcagttaaa atgatctttt aggatgggca cagtggctca cgcctgtaat
    13261 accagcactt tgggaggtgg aggctggctg atccccttag gttgggagtt caagaccatc
    13321 ctcaccaaca gggagaaacc ccatctctac taaaaataca aaaattagcc ggatgtggtg
    13381 ggacgtgtct gtaatcccaa ctacttggga ggctgagaca ggagaactgc ttgaacccgg
    13441 gaggtggagg ttgcagtgag ccagaatcgt gccacagcac tccagcctgg gcaagaagcg
    13501 cgaaactccg tctcaaaata aaataatctt ctaaaaatga cagggccagg tggggtggca
    13561 cttttttata atccgagcac tttgggaggc tgaggtgggc agatcgcttg acatcagggg
    13621 tttgagacca gcctggccaa catggtgaaa cttcgtctct actaaaaata ctaaaaatta
    13681 gctgggcgtg gtggcgggtg cctgtaatcc cagctactcg ggaggctgat gcaggagaat
    13741 cgcctgaacc aggcagatgc aggatgcagt gagccaagat taagacactg cactccaacc
    13801 taagcaatac tttgtctcaa aaataaaaaa aagcctggga aacaaagtga gaccccgtct
    13861 ctacaaaaaa gtcaaaaaat tagctgggta tggtggcagt gatggcacac acctgtagtc
    13921 ccggctactt gggaagcttt ttaatatttt ttgcagagac cgggtctcac tctgttacct
    13981 ggcctggtct tgaactcctg ggctccaaca atcccctttc ctgggcctcc caaagtgctg
    14041 ggattagagg catgagccac cgtgcccagc ctcaaagcat attttaaagg atagaaataa
    14101 acagccatat gaagagatac agacagggcg gtctggaagg gtccagagca ggagcttcta
    14161 tctccataga gttggggtta cgtcaccctc tgggcacatt ctgtcagcct ccacacgttc
    14221 agctctcaga agctcccgaa ccctgtcctt tgggcctttt atggagaact ccattggctg
    14281 tccatgactg aagcatggac aactgtgata atgtgattgg gcaaaaaggg tctgatctaa
    14341 gcccagcaag gccagtccag attctttggg cctttgtgca gcattccttt ctccagggta
    14401 tggggcaagg acccactctg gaatgaggat cctacaaccc acaatcagat tagagtcctg
    14461 ccttgggcag ctgaaaagag gacaggagaa ggtcagagag acgaaaggct gttttttgag
    14521 gcctgaggca ccccaacatg acaacgtaag actgtaacca tggtcatgtg agttatgagc
    14581 taggaaccct ggacgaaacc aacacatata caatcatctc ccacctccca acgcctttac
    14641 tttcacagcc tctgcagcaa actgcggtca ctataatcgc tcctgtggca cagaggcata
    14701 cccaggggaa tctgcccagg gggccactct gtgcccacgt gggaacccac acctgcttgt
    14761 aaagcctccc ctccctctga ccagcaacca ggacagtttg ttgttccaag cagtgggctc
    14821 atgtctgttt tggctcagaa cagggtgggg agagcgggcc agggacccga ggaaggctta
    14881 tccttgagat tgcgtgggag acacaacaag gggtgggggc ccgcaggcgg ggcggggcga
    14941 agcaggtgat atcaagccca gagccccagc ctctccccac agtctcacca tggcccgcac
    15001 cgtggtgctc atcaccggct gttcctcggg catcggcctg cacttggccg tacgtctggc
    15061 ttcagatcca tcccagagct tcaaaggtat agataggcag ggacagggag ggagagaagg
    15121 gaggagccct tggaggctag aagggaagtc agatcttcct cctctcccaa aacctccagt
    15181 gtatgccacg ttgagggacc tgaaaacaca gggccggctg tgggaggcgg cccgggccct
    15241 ggcatgccct ccgggatccc tggagacgtt gcagctggac gtaagggact caaaatccgt
    15301 ggccgctgcc cgggaacgcg tgactgaggg ccgcgtggac gtgctgggtg agcctcctgg
    15361 aagcatatgg gctcctagga gccttctccg ccctgcgttg aaaccaacat gttcccaggc
    15421 ccagggagca cgaggggaca ggccgtgctg agggtgatgc tgaggcgggc tggtcgggcc
    15481 tcttgtctcc gcagtgtgta acgcaggcct gggcctgctg gggccgctgg aggcgctggg
    15541 ggaggacgcc gtggcctctg tgctggacgt gaatgtagta gggactgtgc ggatgctgca
    15601 ggccttcctg ccagacatga agaggcgcgg ttcgggacgc gtgttggtga ccgggagcgt
    15661 gggaggattg atgggtgagt ggtagggagt ggcctcggca gctccagatt ctttgtgtgc
    15721 ggagctgagc cttgaaggca ggttccgcgg ggagggtgga ggggggtgcc gtcagcttgg
    15781 aggggcaccg tctgcccggg gatgaccccc tggccgctgc gcctcaggaa cctcgtctcc
    15841 ccacctaagg gctgcctttc aatgacgttt attgcgccag caagttcgcg ctcgaaggct
    15901 tatgcgagag tctggcggtt ctgctgctgc cctttggggt ccagtgagtc aacacccccg
    15961 ttccccgaac cctcttaact ctgacctaga gatgccgagc accctgtcct gcgggagccg
    16021 ctctggggcg atctccctgg ccctctctgc ccggctcaca ttagctgtgt gccaggcact
    16081 tgggctgggc gcatggcacg cattgtgcca cctgctgacc tagctgctga agtgttggta
    16141 ttgttatggg gaagctccag cccagagagg ttaggtgact ggcccaaggt cacacagcgg
    16201 ccagggaccc cgctagattc gaatcctgac accagggctc ccttgtagcc tcagatggat
    16261 ttgggagggc tgctccggca ggaacccgcg tttcaaatgt tctggttatc cccagcgccc
    16321 tttccgcctc acttcccagc gcacggtgct gctcgcggtc gggggccggg acgtggttgg
    16381 ggctgggact ggggttgggg ctgggactgg ggcctggctg gcgtccgccc cctcccactc
    16441 gttgctctcc ggccagcagc ttgagcctga tcgagtgcgg cccagtgcac accgccttca
    16501 tggagaaggt gttgggcagc ccagaggagg tgctggaccg cacggacatc cacaccttcc
    16561 accgcttcta ccaatacctc gcccacagca agcaagtctt tcgcgaggcg gcgcagaacc
    16621 ctgaggaggt ggcggaggtg agcgccgggc tggactccag gagtgggggc ggtgcgtcct
    16681 ccggcgcgca gcggtggcca cagctctcct cccgccgccg caggtcttcc tcaccgcttt
    16741 gcgcgccccg aagccgaccc tgcgctactt caccaccgag cgcttcctgc ccctgctgcg
    16801 gatgcgcctg gacgacccca gcggctccaa ctacgtcacc gccatgcacc gggaagtgtt
    16861 cggcgacgtt ccggcaaagg ccgaggctgg ggccgaggct gggggcgggg ccgggcctgg
    16921 ggcagaggac gaggccgggc gcagtgcggt gggggaccct gagctcggcg atcctccggc
    16981 cgccccgcag taaaggcttc ctcagccgct gtctcccgcg cccttctttg tcccctgggt
    17041 ctgtgtggtc cctggggatg gggcggcggt agcagctgtg ggtggctaat taagatagat
    17101 cgcgttagcc agttttacca gcgcagctag gcgcgatggc tgtcgcctgt aatgccagcg
    17161 ctttgggagg cggaggcagg aggatcgctc aagccccgga gttggagacc agccagagca
    17221 acacagtgag acccccatct ctacaaaaat aaagaaaatt taaaaatcag cacagtggca
    17281 ccattccttg agcccaggag ttggagggtg cagtgagcat gatggggcca ctgcactcca
    17341 gcctgggtga cagagtgaga ccctgtcaat taatcaaatg aaccaaccaa ccgaaaaact
    17401 cagaaaccaa ggtccagaaa gaagccagcc caggatcaca cctcaagtcc atattaaagg
    17461 ccagacacag tctctggata cccaaggggc atctgcagga ggagttaggt gggaattggc
    17521 ttggggtaga gtcaggttgt gacttggacc ccattagcca tgagacctca ggcaagttcc
    17581 ttgctttctc tcagtctttc ttttctttct ttcctttctt ttttttttat tttctgagac
    17641 agagtttcgc tcttgttgcc taggctggag tgcaatgggg caatctcggc tcaccacaat
    17701 ctccgcttcc cagattcaag tgattctcct gcctcagcct cccaagtagc tgggataccg
    17761 gctaattttg tatgttcggt agagacgggg tttctccatg ttggtcaggc tggtctcaaa
    17821 ctctcgacct taggtgatcc gcccgcctcg gcctctcaga ttgctgggca tacaggcatg
    17881 agccaccgcg accggccctc tgagtctttc ttatctgtaa aatgggtata ataataccta
    17941 tctaatcggt tttagtaatg gtggagataa tgcctgaaag tgctagtata gaggtttaat
    18001 agccagcaag gactgttatt agaatgaata gtaatatgac tactgtcaca ttttgcaaat
    18061 gtgtaaagaa gagggctaag tgaatcaaag ggagacagcc ccactcaccc tgttctgccc
    18121 cagaggactg agcgatcccc accatctggc aagctgcctc accaggaggt ccagctgggg
    18181 ctacaggact ggctactttg ctacaatggc ctgtctttcc tgagcccagt ggagggtccc
    18241 aggggggcag aagtcattga taggggccag tagggttgta gagccactgt ctgaacttct
    18301 gtggaggtct ggtgcagggg aggtgtgaac agataggagg ctaggtgagg atgcagcaga
    18361 ggaaggggca ggagtgccca ggagggggcg gtaccgaggc agggattcag ctgggtctga
    18421 gagggaggca aggctgaggg ggatggccct ttggagtggg cagggacatg accacagaaa
    18481 gcctgggaag tggaaacaga caggagcctg ttggagctct tggagctttg tgtggggcac
    18541 tgggggaagg aggcaggcac tccaccctga cctgccccta cctcggatga gggtcttctc
    18601 tgcctgttgg atgatgtgct gcccctgctc ttggaggaag aggcctccca gccaccccct
    18661 cctgccagtc gccctgacct gctgacccag acagatctgc tatccctaca gcatccagga
    18721 aggccacagg gagggggccc aggtggcatg ggtttctgag gcctgggatc tgctctcagt
    18781 ccccgtctcg ccaaccccct ttgcccctct gtgacagtgt gtgtacatat gcgtgcatgt
    18841 gtgtacctgt gtggtgtggc tcacaaggtc acccctgggg gtgggataat aagaggtaaa
    18901 gtgtgacccc ctctcttccg tacattcatt ttttcaagct tgtgaatatt cacattgtta
    18961 atataatctt ctgcagtccc atgacttcga atagcactta gatgccgatg acccccccac
    19021 caaagaaacc ccactgtctc ccacagactc caggtctgta tctccaactg cctactcaat
    19081 acaacacgtc cacctgatgc aatgaactta atgtgtctaa accccaattc cacatttcca
    19141 gtcctcctac cggctcctcc cccagtcttc tctactttac tgtatgacaa ctccattttt
    19201 cccaatactg gttttaaaaa ccctggagta gtccttgact ccagtctctc tcacctttca
    19261 accaattcag cagcaaatac tgacagctct acctttgctc atcaaagcat attccaaaat
    19321 caccctattc gagactgcac actgtcatct ttcccttcaa ttacagcagt agcctcctaa
    19381 ctagttttct tgattccact cttgcccatc agcagtaaaa ttagcacagt gcatttaaaa
    19441 tgatctttta aaaatgacag ggccgggcgt gatggctcat gcctataatc acagcacttt
    19501 gtgaggctga ggcggacgtt attgcttgag gtcaggagtt tgagaccaac ctggccaata
    19561 tggtgaaacc ctgtgtctac taaaaatata aaaattagcc aggcatggtg gtgggcgcct
    19621 gtaatcgcag ctgctccaga ggctgacaaa ggagaatctc ttgaaccagg gaggtggagg
    19681 ctgcagtgag ccaagattgg gacactgcac tccagcctgg gcaacagaga ctttgtctca
    19741 aaaaaataaa aattggccgg gcgtggtggc tcatgcctgt aatcccagca ctttgggagg
    19801 ccgaggcggg tggatcacct gaggtcagga gttcaagacc agcctggcca acagggtgaa
    19861 accttgtctc tactaaaaac ccaaaaaatt agccaggcgt ggtggcacgt gcctgtaatc
    19921 ccagctactc aggcggctga ggcaggggaa ttgcttgaac cccggagcgg tacgctgcag
    19981 tgagtggaga ttgcgccatt gtactctagc ctgggcaaca agagtgaaac tccatctcaa
    20041 aataataata ataaaattaa aaaaaattta aaataaaaaa gggagcctgg gcaacaaagt
    20101 gagaccccgt ctctacgaaa aaacaaaaaa aatagttggg tgtggttgca cacatctgta
    20161 gtcccagctt cttgggaggc tgacatggga agactgtttg agcccaggag gttgaggcca
    20221 cagtaagctg tgggcacacc actgcattcc agcctgggca agagagggag accctgtctc
    20281 ataaaagaaa gaaagaggcc aggtgtggtg gctacgcctg taatcccaac actttgggag
    20341 cccaaggccg gtgaatcact tgagatcagg agttcgagac cagcctggcc aacatggtaa
    20401 aaccccgtct ctactaaaaa tacaaaaatt agctgggcgt ggtagtttgt gcctgtaatc
    20461 ccagctactg gggaggctga ggcaggagaa tcgcttgaac ccgggagacg aaggttgcag
    20521 tgagctgaga tttctccact gcactccagc ctgggtaaag agtgagactc ggccgggtgc
    20581 ggtggctcat gtctttaatc ccagcacttt gggaggccga ggcgggtgga tcacctgagg
    20641 tcaggagttc aagaccagcc tggccaacct ggtgaaagcc tgtctctact aaaaatagaa
    20701 aaattagctg ggcgtggtgg tgggtgcctg taatcccagc tactcaggag gctgaagcag
    20761 gagaatcact tgaacctggg aggcagaggt tgcagtgagc cgagatcatg cgttgcactc
    20821 caacctgggt gacagtgaga ctctgtctta aaacaaaaca aaagaagcaa agtttatttt
    20881 gctcagagct tcacagtttt aggggctgga aagtgcaaga acctcatgca gtatctggca
    20941 aagggctgtc ccaggatgga agggcagaag gtggaagcaa atgagagaca cgaaattggg
    21001 ccaaatgtcg tccatccatc aggagccact cccatgataa cagtatttat ctattcaaga
    21061 gggcagagcc ctcatgatct aattatcttt tttttttttc tcctgcctcg gcctcttgag
    21121 aagctgggat tttaggcgca tgccaccaca ccccgctaat ttttgtactt ttagtagaga
    21181 cggggtttca ccacgttggt tgggctggtc gcaaactcct gatctcaggt gatccacctg
    21241 agatccacca ctttggcttc ccaaagtgct gagattacag gagtgagcca cctcgcccag
    21301 ctgacctaat tacctcttaa aggccccacc ctgcccagtg cagtggctca ggcctgtaat
    21361 cccaacactt tgggaggctg aagtgggagg actgcttgag ttcaggagtt ggaaaccagc
    21421 ccaggcaaca cagcaagatc ctgtctgtat gaaaaaaaaa attttttttt taattagcca
    21481 ggtgtggtgg cacacatctg tagttccagc tgctcaggag gccaaggcag aggactgctt
    21541 gagcccaggc agttgaggct gctgtgagcc atgatcaacc cactgcactc cagcctgggg
    21601 gacaagagtg agaccctgtc tcaaagagaa aaaaagtccc atctcttaag acagtagcaa
    21661 ttgaattttt tatttcaaca tgagttgtgg cagggacatt cgaaccatag caccaaggtt
    21721 ctccccaaag ctctccaaga ccttctttga tctggttcct gccccctttc tgatccgttg
    21781 acctgcag
//