From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens (clone K6) microtubule (beta) associated protein tau 1
Date: 21 Dec 92 20:47:29 GMT
Distribution: bionet
Checksum: 02779 4

LOCUS       HUMTAU        954 bp ds-DNA             PRI       20-NOV-1992
DEFINITION  Homo sapiens (clone K6) microtubule (beta) associated protein tau 1
            (MTB1) gene, complete exon 4A.
ACCESSION   M93652
KEYWORDS    binding and bundling protein; cytoplasmic protein;
            microtubule (beta) associated protein tau 1;
            neuronal axon maintenance.
SOURCE      Homo sapiens (library: cosmid; pWE15) adult DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 954)
  AUTHORS   Andreadis,A., Brown,W.M. and Kosik,K.S.
  TITLE     Structure and novel exons of the human tau gene
  JOURNAL   Biochemistry 31, 10626-10633 (1992)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Goedert,M., Spillantini,M.G. and Crowther,R.A.
  TITLE     Cloning of a big tau microtubule-associated protein characteristic
            of the peripheral nervous system
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 1983-1987 (1992)
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   Couchie,D., Mavilia,C., Georgieff,I.S., Liem,R.K., Shelanski,M.L.
            and Nunez,J.
  TITLE     Primary structure of high molecular weight tau present in the
            peripheral nervous system.
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 4378-4381 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     intron          <1..61
                     /gene="MTBT1"
     intron          815..>954
                     /gene="MTBT1"
     CDS             62..814
                     /standard_name="Tau"
                     /gene="MTBT1"
                     /label=exon 4A
                     /citation=[2]
                     /citation=[1]
                     /citation=[3]
                     /partial
                     /note="Tau"
                     /codon_start=3
                     /translation="PESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQ
                     PSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDES
                     SPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPD
                     GPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLG
                     EDTKEADLPEPSEKQPAAAPRGKPVSRVPQLK"
BASE COUNT      190 a    330 c    293 g    141 t
ORIGIN      
        1 gactgggccg agaagggtcc ggcctttccg aagcccgcca ccactgcgta tctccacaca
       61 gagcctgaaa gtggtaaggt ggtccaggaa ggcttcctcc gagagccagg ccccccaggt
      121 ctgagccacc agctcatgtc cggcatgcct ggggctcccc tcctgcctga gggccccaga
      181 gaggccacac gccaaccttc ggggacagga cctgaggaca cagagggcgg ccgccacgcc
      241 cctgagctgc tcaagcacca gcttctagga gacctgcacc aggaggggcc gccgctgaag
      301 ggggcagggg gcaaagagag gccggggagc aaggaggagg tggatgaaga ccgcgacgtc
      361 gatgagtcct ccccccaaga ctcccctccc tccaaggcct ccccagccca agatgggcgg
      421 cctccccaga cagccgccag agaagccacc agcatcccag gcttcccagc ggagggtgcc
      481 atccccctcc ctgtggattt cctctccaaa gtttccacag agatcccagc ctcagagccc
      541 gacgggccca gtgtagggcg ggccaaaggg caggatgccc ccctggagtt cacgtttcac
      601 gtggaaatca cacccaacgt gcagaaggag caggcgcact cggaggagca tttgggaagg
      661 gctgcatttc caggggcccc tggagagggg ccagaggccc ggggcccctc tttgggagag
      721 gacacaaaag aggctgacct tccagagccc tctgaaaagc agcctgctgc tgctccgcgg
      781 gggaagcccg tcagccgggt ccctcaactc aaaggtctgt gtcttgagct tcttcgctcc
      841 ttccctgggg acctcccagg cctcccaggc tgcgggcact gccactgagc ttccaggcct
      901 cccgactcct gctgcttctg acgttcctag gacgccacta aatcgacacc tggg
//