From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse MHC HAM2 (required for antigenic peptide loading onto class I
Date: 25 Jul 92 10:04:48 GMT
Distribution: bionet
Checksum: 06069     5

LOCUS       MUSMHHAM2A   2109 bp ss-mRNA            ROD       25-JUL-1992
DEFINITION  Mouse MHC HAM2 (required for antigenic peptide loading onto class I
            MHC molecules) mRNA, complete cds.
ACCESSION   M90459
KEYWORDS    major histocompatibility complex.
SOURCE      Mus musculus (individual_isolate RBL-5, strain c57bl/6) (library:
            made in cDNA II) thymus cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   Yang,Y., Frueh,K., Chambers,J., Waters,J.B., Wu,L., Spies,T. and
            Peterson,P.A.
  TITLE     Major histocompatibility complex (MHC)-encoded HAM12 is necessary
            for antigenic peptide loading onto class I MHC molecules
  JOURNAL   J. Biol. Chem. 267, 11669-11672 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             1..2109
                     /function="Required for antigenic peptide loading onto
                     class I MHC molecules"
                     /gene="HAM2"
                     /codon_start=1
                     /translation="MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTL
                     RLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWL
                     LAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVV
                     AVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMS
                     RINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVK
                     VVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREA
                     VGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILN
                     CGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKP
                     NLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGK
                     STVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYG
                     LRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNP
                     RVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEH
                     DQLRDGQDVYAHLVQQRLEA"
BASE COUNT      397 a    573 c    683 g    456 t
ORIGIN      Chromosome 17.
        1 atggcgctgt cctacctgag gccctgggtc tctctgctgc tggcggacat ggctttactt
       61 gggttgctac aaggatctct gggaaatctg cttccccagg ggctgccagg actctggata
      121 gagggcaccc tgcgacttgg agtgctgtgg ggactgctaa aagtgggaga gctgctggga
      181 cttgtgggga cccttctgcc cttgctctgc cttgccactc ccctgttttt ctcgctaaga
      241 gctctggtgg gaggcaccgc gagcacctca gtagtccgag tggcttctgc ctcttggggc
      301 tggctgctgg ctggctatgg ggctgttgcg ctgagctggg ccgtgtgggc tgtgctgagc
      361 ccggctggag tccaggagaa ggaaccaggc caggagaaca gaacactgat gaagcggttg
      421 ctgaagctgt ccaggccgga cctgcctttc ctcatagctg ccttcttctt ccttgtggtg
      481 gctgtgtggg gggagacatt aatccctcgc tattcgggtc gtgtaattga catcctggga
      541 ggtgatttcg accccgacgc ctttgcaagc gccatctttt tcatgtgcct gttctctgtt
      601 gggagctcct tctctgcagg ctgtagagga ggctccttcc tcttcaccat gtccaggatc
      661 aacctgcgga tacgagagca gcttttctca tctttgttgc gccaagacct tggattcttc
      721 caggagacca agacagggga gctgaactcg aggctgagct ctgacacctc tctgatgagc
      781 cgctggctcc ctttcaatgc caatatcctg ctgcggagcc tggtgaaggt ggtggggctc
      841 tacttcttca tgctccaggt atcgccccga ctcaccttcc tctccctgct ggacctgccc
      901 ctcacgatag cagctgagaa ggtgtacaac ccccgccatc aggcggtgct aaaggagatc
      961 caggatgcag tggccaaggc ggggcaggtg gtgcgcgagg cggtaggagg gctgcagact
     1021 gtgcgaagct ttggggccga ggagcaggaa gtcagccact acaaggaggc cctggagcga
     1081 tgtagacagc tgtggtggcg ccgagacctg gaaaaagacg tgtatctagt catacggagg
     1141 gtgatggcct tgggcatgca ggtgctgatt ctgaactgcg gcgtgcagca gattctggct
     1201 ggagaggtca cccggggtgg cctgctctcc ttcctgctgt accaggagga agtgggacaa
     1261 tatgtccgga acctggttta catgtacggg gatatgctga gcaacgtggg cgctgctgaa
     1321 aaggtgtttt cctacctgga ccgaaagccg aatctgcccc agcctgggat cctggcccct
     1381 ccctggctgg aggggcgcgt ggaattccaa gacgtctcct tttcgtatcc caggcgcccc
     1441 gagaagcctg tgctccaggg tctgacgttc accctgcatc ctggaacggt gacagcgttg
     1501 gtgggaccca atggatcagg gaagagcacc gtggccgccc tgctgcagaa cctgtaccag
     1561 cccactgggg gccagctgct gctggatggc gagcccctga ccgagtatga tcaccactac
     1621 ctgcaccgcc aggtggttct ggtggggcag gagcctgtgc tgttctcggg ttctgtcaag
     1681 gacaatattg cctatggcct gagggactgt gaggacgctc aagtgatggc agctgcccag
     1741 gcggcctgtg cagacgactt cataggggaa atgactaatg gaataaacac agaaatcggg
     1801 gaaaaagggg gccagttagc tgtgggacag aagcaacgtc tggccattgc ccgggccctt
     1861 gtgcggaacc cacgggtcct catcctggat gaggctacca gcgccctgga cgcccagtgt
     1921 gaacaggccc tacagaactg gagatcgcag ggggacagga cgatgctggt gattgcccac
     1981 aggctgcaca cggttcagaa tgctgaccaa gttctggtgc tcaagcaggg acgtctggtg
     2041 gagcatgacc agctcaggga cggccaggat gtctacgccc acctggtaca gcagcggctg
     2101 gaggcatga
//