From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens carbonyl reductase gene, complete cds.
Date: 9 Apr 92 10:03:18 GMT
Distribution: bionet
Checksum: 52071     6

LOCUS       HUMCBRG      3326 bp ds-DNA             PRI       09-APR-1992
DEFINITION  Homo sapiens carbonyl reductase gene, complete cds.
ACCESSION   M62420
KEYWORDS    carbonyl reductase.
SOURCE      Human, DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3326)
  AUTHORS   Forrest,G.L., Akman,S., Doroshow,J., Rivera,H. and Kaplan,W.D.
  TITLE     Expression of a cloned genomic human carbonyl reductase gene with
            daunorubicin reductase activity
  JOURNAL   Mol. Pharmacol. 40, 502-507 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     mRNA            join(185..566,1112..1219,2608..3044)
                     /gene="CBR"
     CDS             join(278..566,1112..1219,2608..3044)
                     /EC_number="1.1.1.184"
                     /product="carbonyl reductase"
                     /gene="CBR"
                     /codon_start=1
                     /translation="MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQ
                     AAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTP
                     FHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRS
                     ETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKG
                     DKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQ
                     W"
     exon            185..566
                     /number=1
                     /gene="CBR"
     exon            1112..1219
                     /number=2
                     /gene="CBR"
     exon            2608..3044
                     /number=3
                     /gene="CBR"
BASE COUNT      755 a    902 c    802 g    867 t
ORIGIN
        1 gcctcggtct tcggcctgcg ggttctgcaa agtcaggcta gctggctctc cgcctgctcc
       61 gcaccccggc gaggttccgg tggggagggg tagggatggt tcagccccgc cccgctaggg
      121 cggggcctgc gcctgcgcgc tcagcggccg ggcgtgtaac ccacgggtgc gcgcccacga
      181 ccgccagact cgagcagtct ctggaacacg ctgcggggct cccgggcctg agccaggtct
      241 gttctccacg caggtgttcc gcgcgccccg ttcagccatg tcgtccggca tccatgtagc
      301 gctggtgact ggaggcaaca agggcatcgg cttggccatc gtgcgcgacc tgtgccggct
      361 gttctcgggg gacgtggtgc tcacggcgcg ggacgtgacg cggggccagg cggccgtaca
      421 gcagctgcag gcggagggcc tgagcccgcg cttccaccag ctggacatcg acgatctgca
      481 gagcatccgc gccctgcgcg acttcctgcg caaggagtac gggggcctgg acgtgctggt
      541 caacaacgcg ggcatcgcct tcaagggtat ggggagggga cgtggcctcc ccgaagaaga
      601 accgatgcac tggggctcct ggcgtctgcg gggtccataa cgcctcccta gggaggagag
      661 ggaggagcta ggagatgcag ggagtgcaga aaccttggag aaagtgagag ttttccagcc
      721 aaagggaact ttgtgtttcc ctggctggga ctcttgggga tctttttcag gttttctgca
      781 gtttttctga attgagcttt aaggcaactg gatggatttt gaactgattt taaaataaac
      841 gacaaattgc aaaaagaaaa aatggttatg ccaagatcca gtgtgtgcac ccttcatcct
      901 ccttccccca atggtgccat cttacaaaaa tactagaaca tgatcaaacc aggagattga
      961 cattggcaca atactgtaac cagatacaga cttactttag gcagagggca ctaagttttt
     1021 gttttttttt tttttttttt ttagtatcat tgtatagaat tttaccccat gggtacaatg
     1081 tattaactat gttctctttc tctcctaaaa gttgctgatc ccacaccctt tcatattcaa
     1141 gctgaagtga cgatgaaaac aaatttcttt ggtacccgag atgtgtgcac agaattactc
     1201 cctctaataa aaccccaagg tgagtctgat gggaaacagc gcaccttctc tttggggctt
     1261 gatttggccc ctgcttgcct gggatttctc ctgcaggctc ctgcttcctc tccatgctgc
     1321 acgtgcactg acctctgtgc tttttctcct gccagctgat atgtgccatt ttgcctcagg
     1381 actttgtcct cacttctccc actcccatgg ccattcgtcc tccctgtcgc actggtcttt
     1441 gcacacctgg ctgactctca tccttcaggt cttagctcaa acgtctcctg agagatgctc
     1501 tttatttgct ccattcccct ccgcgtggga gtccatcctg taccctttct ctgctctttc
     1561 agagagatct tattcaggct ggtggaggct ttactaccac cagttcatta ggcccttcta
     1621 atacctgtca cctgtctgaa acactcctta agctcccaac cacatggttg tcttgctgcc
     1681 tttccatctc ttcctgatgc ctttccccac aatctaagat atttccagag gatccctatc
     1741 cttttcccta agtcgtttgg gacacagacc ccaccaccca cccaccagga tcctgcaggt
     1801 caccatgccc cacccctcat aatcatttac taggtcctag gagtagtgcc cactgagttc
     1861 ctcctgaatc cgtctcattg cagctctaca gcaggccctc acctgtccct ctggacaatt
     1921 gcaaaccctc acaaggcacc tctggtcttg agtcttttcc tcttttcctt tcccagcatc
     1981 ctgcgtactg tctgcatggt catgcctctc ccaaaatcct tcaggaggaa agtccaagcc
     2041 cttagcatgg ttcacagaga tgtccataat ctgccgctgc ttaactctgg gcccatttta
     2101 actccccttc aacgtgctga aggtgctgga catgactatc acatgtcttt ggttgtaaac
     2161 tgctgtgata gttaccctaa gtaatgggac aggagatgaa cccacccatt aaataacaca
     2221 gcaattaagc agccactttt agaaaaattt aaatgtgtgg cttcgagttg ggtacttgca
     2281 tgtacagctt actctcagct tttatcctgt ttccctgtcc tgtcgtcctg ttaagttgtg
     2341 ctacttctaa ggctctggtt caccaggacc tcaaagggca gctcttccaa atctcacctg
     2401 actctactca gccaaaattc gaaggcagga atgaacttct tcatgcaact accaccacac
     2461 tttctatgcg tattcctctt agaactcata ccagtaactg tctctcatat gaaaattttc
     2521 tgctccaaaa tccctgcaaa tttggcattc acctctctac gggattgttg cacacctttc
     2581 tacataatgc tttgtggtgt atcttaggga gagtggtgaa cgtatctagc atcatgagcg
     2641 tcagagccct taaaagctgc agcccagagc tgcagcagaa gttccgcagt gagaccatca
     2701 ctgaggagga gctggtgggg ctcatgaaca agtttgtgga ggatacaaag aagggagtgc
     2761 accagaagga gggctggccc agcagcgcat acggggtgac gaagattggc gtcaccgttc
     2821 tgtccaggat ccacgccagg aaactgagtg agcagaggaa aggggacaag atcctcctga
     2881 atgcctgctg cccagggtgg gtgagaactg acatggcggg acccaaggcc accaagagcc
     2941 cagaagaagg tgcagagacc cctgtgtact tggccctttt gcccccagat gctgagggtc
     3001 cccatggaca atttgtttca gagaagagag ttgaacagtg gtgagctggg ctcacagctc
     3061 catccatggg ccccattttg taccttgtcc tgagttggtc caaagggcat ttacaatgtc
     3121 ataaatatcc ttatataaga aaaaaaatga tctcttatca attagcactc actaatgtac
     3181 tactaattga gcaacctacg cactcagttg actacgtaaa tctgtcaggt cttttgtgat
     3241 ttcctctgat gcaggagagg aaaaattgta attgatgaaa ataatgaatg aaaatcaaca
     3301 gatgaataaa tggttcttta taagtg
//