From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human protein tyrosine phosphatase zeta-polypeptide (PTPRZ) mRNA,
Date: 3 Sep 92 10:01:00 GMT
Distribution: bionet
Checksum: 39624    15

LOCUS       HUMPTPRZ     7941 bp ss-mRNA            PRI       03-SEP-1992
DEFINITION  Human protein tyrosine phosphatase zeta-polypeptide (PTPRZ) mRNA,
            complete cds.
ACCESSION   M93426
KEYWORDS    carbonic anhydrase-related transmembrane protein;
            protein tyrosine phosphatase zeta-polypeptide.
SOURCE      Homo sapiens (library: lambda gt10 and gt11) fetus brain cDNA to
            mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 7941)
  AUTHORS   Krueger,N.X. and Saito,H.
  TITLE     A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
            expressed in brain and has an N-terminal receptor domain homologous
            to carbonic anhydrases
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 7417-7421 (1992)
  STANDARD  unannotated staff_entry
FEATURES             Location/Qualifiers
     CDS             148..7092
                     /note="carbonic anhydrase-like domain"
                     /product="protein tyrosine phosphatase zeta-polypeptide"
                     /gene="PTPRZ"
                     /codon_start=1
                     /translation="MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGAL
                     NQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTV
                     EINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDA
                     DRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILL
                     NLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVM
                     LMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWER
                     PRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAIC
                     TNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSA
                     TNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVT
                     KLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT
                     EYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIP
                     ESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIR
                     VDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVST
                     VNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATP
                     VFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPL
                     HASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSD
                     AMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIP
                     KSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYT
                     TSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQET
                     SVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSA
                     NSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPS
                     DPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTI
                     SYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
                     EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITA
                     VSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDRDSDGL
                     SIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQ
                     TGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQ
                     GTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHV
                     SEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTA
                     HFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF
                     YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINA
                     NYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
                     DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPD
                     MGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV
                     NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP
                     AGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGT
                     DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV
                     YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKW
                     PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSV
                     DVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNI
                     AESLESLV"
BASE COUNT     2406 a   1651 c   1598 g   2286 t
ORIGIN
        1 cacacatacg cacgcacgat ctcacttcga tctatacact ggaggattaa aacaaacaaa
       61 caaaaaaaac atttccttcg ctccccctcc ctctccactc tgagaagcag aggagccgca
      121 cggcgagggg ccgcagaccg tctggaaatg cgaatcctaa agcgtttcct cgcttgcatt
      181 cagctcctct gtgtttgccg cctggattgg gctaatggat actacagaca acagagaaaa
      241 cttgttgaag agattggctg gtcctataca ggagcactga atcaaaaaaa ttggggaaag
      301 aaatatccaa catgtaatag cccaaaacaa tctcctatca atattgatga agatcttaca
      361 caagtaaatg tgaatcttaa gaaacttaaa tttcagggtt gggataaaac atcattggaa
      421 aacacattca ttcataacac tgggaaaaca gtggaaatta atctcactaa tgactaccgt
      481 gtcagcggag gagtttcaga aatggtgttt aaagcaagca agataacttt tcactgggga
      541 aaatgcaata tgtcatctga tggatcagag catagtttag aaggacaaaa atttccactt
      601 gagatgcaaa tctactgctt tgatgcggac cgattttcaa gttttgagga agcagtcaaa
      661 ggaaaaggga agttaagagc tttatccatt ttgtttgagg ttgggacaga agaaaatttg
      721 gatttcaaag cgattattga tggagtcgaa agtgttagtc gttttgggaa gcaggctgct
      781 ttagatccat tcatactgtt gaaccttctg ccaaactcaa ctgacaagta ttacatttac
      841 aatggctcat tgacatctcc tccctgcaca gacacagttg actggattgt ttttaaagat
      901 acagttagca tctctgaaag ccagttggct gttttttgtg aagttcttac aatgcaacaa
      961 tctggttatg tcatgctgat ggactactta caaaacaatt ttcgagagca acagtacaag
     1021 ttctctagac aggtgttttc ctcatacact ggaaaggaag agattcatga agcagtttgt
     1081 agttcagaac cagaaaatgt tcaggctgac ccagagaatt ataccagcct tcttgttaca
     1141 tgggaaagac ctcgagtcgt ttatgatacc atgattgaga agtttgcagt tttgtaccag
     1201 cagttggatg gagaggacca aaccaagcat gaatttttga cagatggcta tcaagacttg
     1261 ggtgctattc tcaataattt gctacccaat atgagttatg ttcttcagat agtagccata
     1321 tgcactaatg gcttatatgg aaaatacagc gaccaactga ttgtcgacat gcctactgat
     1381 aatcctgaac ttgatctttt ccctgaatta attggaactg aagaaataat caaggaggag
     1441 gaagagggaa aagacattga agaaggcgct attgtgaatc ctggtagaga cagtgctaca
     1501 aaccaaatca ggaaaaagga accccagatt tctaccacaa cacactacaa tcgcataggg
     1561 acgaaataca atgaagccaa gactaaccga tccccaacaa gaggaagtga attctctgga
     1621 aagggtgatg ttcccaatac atctttaaat tccacttccc aaccagtcac taaattagcc
     1681 acagaaaaag atatttcctt gacttctcag actgtgactg aactgccacc tcacactgtg
     1741 gaaggtactt cagcctcttt aaatgatggc tctaaaactg ttcttagatc tccacatatg
     1801 aacttgtcgg ggactgcaga atccttaaat acagtttcta taacagaata tgaggaggag
     1861 agtttattga ccagtttcaa gcttgatact ggagctgaag attcttcagg ctccagtccc
     1921 gcaacttctg ctatcccatt catctctgag aacatatccc aagggtatat attttcctcc
     1981 gaaaacccag agacaataac atatgatgtc cttataccag aatctgctag aaatgcttcc
     2041 gaagattcaa cttcatcagg ttcagaagaa tcactaaagg atccttctat ggagggaaat
     2101 gtgtggtttc ctagctctac agacataaca gcacagcccg atgttggatc aggcagagag
     2161 agctttctcc agactaatta cactgagata cgtgttgatg aatctgagaa gacaaccaag
     2221 tccttttctg caggcccagt gatgtcacag ggtccctcag ttacagatct ggaaatgcca
     2281 cattattcta cctttgccta cttcccaact gaggtaacac ctcatgcttt taccccatcc
     2341 tccagacaac aggatttggt ctccacggtc aacgtggtat actcgcagac aacccaaccg
     2401 gtatacaatg gtgagacacc tcttcaacct tcctacagta gtgaagtctt tcctctagtc
     2461 acccctttgt tgcttgacaa tcagatcctc aacactaccc ctgctgcttc aagtagtgat
     2521 tcggccttgc atgctacgcc tgtatttccc agtgtcgatg tgtcatttga atccatcctg
     2581 tcttcctatg atggtgcacc tttgcttcca ttttcctctg cttccttcag tagtgaattg
     2641 tttcgccatc tgcatacagt ttctcaaatc cttccacaag ttacttcagc taccgagagt
     2701 gataaggtgc ccttgcatgc ttctctgcca gtggctgggg gtgatttgct attagagccc
     2761 agccttgctc agtattctga tgtgctgtcc actactcatg ctgcttcaga gacgctggaa
     2821 tttggtagtg aatctggtgt tctttataaa acgcttatgt tttctcaagt tgaaccaccc
     2881 agcagtgatg ccatgatgca tgcacgttct tcagggcctg aaccttctta tgccttgtct
     2941 gataatgagg gctcccaaca catcttcact gtttcttaca gttctgcaat acctgtgcat
     3001 gattctgtgg gtgtaactta tcagggttcc ttatttagcg gccctagcca tataccaata
     3061 cctaagtctt cgttaataac cccaactgca tcattactgc agcctactca tgccctctct
     3121 ggtgatgggg aatggtctgg agcctcttct gatagtgaat ttcttttacc tgacacagat
     3181 gggctgacag cccttaacat ttcttcacct gtttctgtag ctgaatttac atatacaaca
     3241 tctgtgtttg gtgatgataa taaggcgctt tctaaaagtg aaataatata tggaaatgag
     3301 actgaactgc aaattccttc tttcaatgag atggtttacc cttctgaaag cacagtcatg
     3361 cccaacatgt atgataatgt aaataagttg aatgcgtctt tacaagaaac ctctgtttcc
     3421 atttctagca ccaagggcat gtttccaggg tcccttgctc ataccaccac taaggttttt
     3481 gatcatgaga ttagtcaagt tccagaaaat aacttttcag ttcaacctac acatactgtc
     3541 tctcaagcat ctggtgacac ttcgcttaaa cctgtgctta gtgcaaactc agagccagca
     3601 tcctctgacc ctgcttctag tgaaatgtta tctccttcaa ctcagctctt attttatgag
     3661 acctcagctt cttttagtac tgaagtattg ctacaacctt cctttcaggc ttctgatgtt
     3721 gacaccttgc ttaaaactgt tcttccagct gtgcccagtg atccaatatt ggttgaaacc
     3781 cccaaagttg ataaaattag ttctacaatg ttgcatctca ttgtatcaaa ttctgcttca
     3841 agtgaaaaca tgctgcactc tacatctgta ccagtttttg atgtgtcgcc tacttctcat
     3901 atgcactctg cttcacttca aggtttgacc atttcctatg caagtgagaa atatgaacca
     3961 gttttgttaa aaagtgaaag ttcccaccaa gtggtacctt ctttgtacag taatgatgag
     4021 ttgttccaaa cggccaattt ggagattaac caggcccatc ccccaaaagg aaggcatgta
     4081 tttgctacac ctgttttatc aattgatgaa ccattaaata cactaataaa taagcttata
     4141 cattccgatg aaattttaac ctccaccaaa agttctgtta ctggtaaggt atttgctggt
     4201 attccaacag ttgcttctga tacatttgta tctactgatc attctgttcc tataggaaat
     4261 gggcatgttg ccattacagc tgtttctccc cacagagatg gttctgtaac ctcaacaaag
     4321 ttgctgtttc cttctaaggc aacttctgag ctgagtcata gtgccaaatc tgatgccggt
     4381 ttagtgggtg gtggtgaaga tggtgacact gatgatgatg gtgatgatga tgatgacaga
     4441 gatagtgatg gcttatccat tcataagtgt atgtcatgct catcctatag agaatcacag
     4501 gaaaaggtaa tgaatgattc agacacccac gaaaacagtc ttatggatca gaataatcca
     4561 atctcatact cactatctga gaattctgaa gaagataata gagtcacaag tgtatcctca
     4621 gacagtcaaa ctggtatgga cagaagtcct ggtaaatcac catcagcaaa tgggctatcc
     4681 caaaagcaca atgatggaaa agaggaaaat gacattcaga ctggtagtgc tctgcttcct
     4741 ctcagccctg aatctaaagc atgggcagtt ctgacaagtg atgaagaaag tggatcaggg
     4801 caaggtacct cagatagcct taatgagaat gagacttcca cagatttcag ttttgcagac
     4861 actaatgaaa aagatgctga tgggatcctg gcagcaggtg actcagaaat aactcctgga
     4921 ttcccacagt ccccaacatc atctgttact agcgagaact cagaagtgtt ccacgtttca
     4981 gaggcagagg ccagtaatag tagccatgag tctcgtattg gtctagctga ggggttggaa
     5041 tccgagaaga aggcagttat accccttgtg atcgtgtcag ccctgacttt tatctgtcta
     5101 gtggttcttg tgggtattct catctactgg aggaaatgct tccagactgc acacttttac
     5161 ttagaggaca gtacatcccc tagagttata tccacacctc caacacctat ctttccaatt
     5221 tcagatgatg tcggagcaat tccaataaag cactttccaa agcatgttgc agatttacat
     5281 gcaagtagtg ggtttactga agaatttgag acactgaaag agttttacca ggaagtgcag
     5341 agctgtactg ttgacttagg tattacagca gacagctcca accacccaga caacaagcac
     5401 aagaatcgat acataaatat cgttgcctat gatcatagca gggttaagct agcacagctt
     5461 gctgaaaagg atggcaaact gactgattat atcaatgcca attatgttga tggctacaac
     5521 agaccaaaag cttatattgc tgcccaaggc ccactgaaat ccacagctga agatttctgg
     5581 agaatgatat gggaacataa tgtggaagtt attgtcatga taacaaacct cgtggagaaa
     5641 ggaaggagaa aatgtgatca gtactggcct gccgatggga gtgaggagta cgggaacttt
     5701 ctggtcactc agaagagtgt gcaagtgctt gcctattata ctgtgaggaa ttttactcta
     5761 agaaacacaa aaataaaaaa gggctcccag aaaggaagac ccagtggacg tgtggtcaca
     5821 cagtatcact acacgcagtg gcctgacatg ggagtaccag agtactccct gccagtgctg
     5881 acctttgtga gaaaggcagc ctatgccaag cgccatgcag tggggcctgt tgtcgtccac
     5941 tgcagtgctg gagttggaag aacaggcaca tatattgtgc tagacagtat gttgcagcag
     6001 attcaacacg aaggaactgt caacatattt ggcttcttaa aacacatccg ttcacaaaga
     6061 aattatttgg tacaaactga ggagcaatat gtcttcattc atgatacact ggttgaggcc
     6121 atacttagta aagaaactga ggtgctggac agtcatattc atgcctatgt taatgcactc
     6181 ctcattcctg gaccagcagg caaaacaaag ctagagaaac aattccagct cctgagccag
     6241 tcaaatatac agcagagtga ctattctgca gccctaaagc aatgcaacag ggaaaagaat
     6301 cgaacttctt ctatcatccc tgtggaaaga tcaagggttg gcatttcatc cctgagtgga
     6361 gaaggcacag actacatcaa tgcctcctat atcatgggct attaccagag caatgaattc
     6421 atcattaccc agcaccctct ccttcatacc atcaaggatt tctggaggat gatatgggac
     6481 cataatgccc aactggtggt tatgattcct gatggccaaa acatggcaga agatgaattt
     6541 gtttactggc caaataaaga tgagcctata aattgtgaga gctttaaggt cactcttatg
     6601 gctgaagaac acaaatgtct atctaatgag gaaaaactta taattcagga ctttatctta
     6661 gaagctacac aggatgatta tgtacttgaa gtgaggcact ttcagtgtcc taaatggcca
     6721 aatccagata gccccattag taaaactttt gaacttataa gtgttataaa agaagaagct
     6781 gccaataggg atgggcctat gattgttcat gatgagcatg gaggagtgac ggcaggaact
     6841 ttctgtgctc tgacaaccct tatgcaccaa ctagaaaaag aaaattccgt ggatgtttac
     6901 caggtagcca agatgatcaa tctgatgagg ccaggagtct ttgctgacat tgagcagtat
     6961 cagtttctct acaaagtgat cctcagcctt gtgagcacaa ggcaggaaga gaatccatcc
     7021 acctctctgg acagtaatgg tgcagcattg cctgatggaa atatagctga gagcttagag
     7081 tctttagttt aacacagaaa ggggtggggg gactcacatc tgagcattgt tttcctcttc
     7141 ctaaaattag gcaggaaaat cagtctagtt ctgttatctg ttgatttccc atcacctgac
     7201 agtaactttc atgacatagg attctgccgc caaatttata tcattaacaa tgtgtgcctt
     7261 tttgcaagac ttgtaattta cttattatgt ttgaactaaa atgattgaat tttacagtat
     7321 ttctaagaat ggaattgtgg tatttttttc tgtattgatt ttaacagaaa atttcaattt
     7381 atagaggtta ggaattccaa actacagaaa atgtttgttt ttagtgtcaa atttttagct
     7441 gtatttgtag caattatcag gtttgctaga aatataactt ttaatacagt agcctgtaaa
     7501 taaaacactc ttccatatga tattcaacat tttacaactg cagtattcac ctaaagtaga
     7561 aataatctgt tacttattgt aaatactgcc ctagtgtctc catggaccaa atttatattt
     7621 ataattgtag atttttatat tttactactg agtcaagttt tctagttctg tgtaattgtt
     7681 tagtttaatg acgtagttca ttagctggtc ttactctacc agttttctga cattgtattg
     7741 tgttacctaa gtcattaact ttgtttcagc atgtaatttt aacttttgtg gaaaatagaa
     7801 ataccttcat tttgaaagaa gtttttatga gaataacacc ttaccaaaca ttgttcaaat
     7861 ggtttttatc caaggaattg caaaaataaa tataaatatt gccattaaaa aaaaaaaaaa
     7921 aaaaaaaaaa aaaaaaaaaa a
//