From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rous sarcoma virus genome, complete sequence.
Date: 9 Jan 93 05:45:29 GMT
Distribution: bionet
Checksum: 13501 16

LOCUS       ALRSRD       9317 bp ss-RNA             VRL       09-JAN-1993
DEFINITION  Rous sarcoma virus genome, complete sequence.
ACCESSION   D10652
KEYWORDS    core proteins; envelope protein; integrase; retroviral protease;
            reverse transcriptase; src oncogene; tyrosine kinase.
SOURCE      Rous sarcoma virus (strain Schmidt-Ruppin D) cDNA to genomic RNA.
  ORGANISM  Rous sarcoma virus
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Retroviridae; Oncovirinae; Type C oncovirus group; Avian sarcoma
            viruses.
REFERENCE   1  (bases 1 to 9317)
  AUTHORS   Kihira,Y.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     Submitted (28-Feb-1992) to DDBJ by: Yasunori Kihira Nagahama
            Institute for Biochemical Science Oriental Yeast Co., Ltd. 50
            Kano-cho, Nagahama-shi Shiga 526 Japan Phone:  0749-64-2346 Fax:
            0749-63-7910.
FEATURES             Location/Qualifiers
     LTR             1..21
                     /note="R region"
     LTR             22..101
                     /note="U5 region"
     mat_peptide     372..902
                     /codon_start=1
                     /note="reading frame p19"
     mat_peptide     909..1082
                     /codon_start=1
                     /note="reading frame p10"
     mat_peptide     1083..1802
                     /codon_start=1
                     /note="reading frame p27"
     mat_peptide     1830..2096
                     /codon_start=1
                     /note="reading frame p12"
     mat_peptide     2097..2468
                     /codon_start=1
                     /note="reading frame p15"
     mat_peptide     2489..5173
                     /product="reverse transcriptase"
                     /gene="pol"
                     /codon_start=1
                     /note="stop codon taa follows at 5174-5176"
     mat_peptide     5064..6884
                     /product="envelope protein"
                     /gene="env"
                     /codon_start=1
                     /note="stop codon taa follows at 6885-6887"
     LTR             9071..9296
                     /note="U3 region"
     LTR             9297..9317
                     /note="R region"
     CDS             372..2471
                     /gene="gag"
                     /product="gag polyprotein"
                     /codon_start=1
                     /translation="MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSD
                     LYSPGSWDPITAALSQRAMILGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGG
                     GRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEEAATPKTVGTSCYHCGTA
                     VGCNCATATASAPPPPYVGSGLYPSLAGVGEQQGQGDRAEQPREEPGHAGQAPGPALT
                     DWARVREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAE
                     VEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGR
                     GERTNLDRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPWAD
                     ITQGPSESFVDFANRLIKAVEGSDLPPTARAPVIIDCFRQKSQPDIQQLIRAAPSTLT
                     TPGEIIKYVLDRQKTAPLTDQGIAAAMSSAIQPLVMAVVNRERDGQTGSGGRARGLCY
                     TCGSPGHYQAQCPKKRKSGNSRERCQLCDGMGHNAKQCRKRDGNQGQRPGRGLSSGPW
                     PGPEQPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISEED
                     WPTDWPVVDTANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVRGS
                     ILGRDCLQGLGLRLTNL"
     CDS             7267..8847
                     /gene="src"
                     /note="transforming gene"
                     /product="tyrosine kinase"
                     /codon_start=1
                     /translation="MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNTTAAPDTH
                     RTPSRSFGTVATEPKLFGDFNTSDTVTSPQRAGALAGGVTTFVALYDYESWIETDLSF
                     KKGERLQIVNNTEGNWWLAHSVTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESER
                     LLLNPENPRGTFSVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRT
                     QFSSLQQLVTYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQG
                     CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLQHEKLVQLYAVVSEEPI
                     YIVIEYMSKGSLLNFLKGEMGKYLRLPQLVDMAAQIASSMAYVERMNYVHRDLRAANI
                     LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI
                     LLTELTTKGRVPYPGMGNGEVLDRVEEGYRMPCPPECPESLHDLMCQCWRRDPEERPT
                     FEYLQAQLLPACVLEVAE"
BASE COUNT     2216 a   2362 c   2704 g   2035 t
ORIGIN      
        1 gccatttgac cattcaccac attggtgtgc acctgggttg atggccggac cgttgagtcc
       61 ctaacggttg cgaacacctg gatgaagcag aaggcttcat ttggtgaccc cgacgtgata
      121 gttagggaat agtggtcggc cacagacggc gtggcgatcc tgtctccatc cgtctcgtct
      181 atcgggaggc gagttcgatg accctggtgg agggggctgc ggcttaggga ggcagaagct
      241 gagtaccgtc ggagggagct ccagggcccg gagcgactga cccctgccga gaactcagag
      301 ggtcgtcgga agacggagag tgagcccgac gaccacccca ggcacgtctt tggtcggcct
      361 gcggatcaag catggaagcc gtcattaagg tgatttcgtc cgcgtgtaaa acctattgcg
      421 ggaaaacctc tccttctaag aaggaaatag gggccatgtt gtccctgtta caaaaggaag
      481 ggttgcttat gtctccctca gatttatatt ctccggggtc ctgggatccc atcactgcgg
      541 cgctctccca gcgggcaatg atacttggaa aatcgggaga gttaaaaacc tggggattgg
      601 ttttgggggc attgaaggcg gctcgagagg aacaggttac atctgagcaa gcaaagtttt
      661 ggttgggatt agggggaggg agggtctctc ccccaggtcc ggagtgcatc gagaaaccag
      721 ctacggagcg gcgaatcgac aaaggggagg aagtgggcga aacaactgtg cagcgagatg
      781 cgaagatggc gccggaggaa gcggccacac ctaaaaccgt tggcacatcc tgctatcatt
      841 gcggaacagc tgttggctgc aattgcgcca ccgccacagc ctcggcccct cctccccctt
      901 atgtggggag tggtttgtat ccttccctgg cgggggtggg agagcagcag ggccagggag
      961 atagggcgga gcagccaagg gaggagccag ggcacgcggg tcaggcccct gggccggccc
     1021 tgactgactg ggcaagggta agagaggagc ttgcgagtac aggtccgccc gtggtggcca
     1081 tgcccgtagt gattaagaca gagggacccg cctggacccc tctggagcca aaattgatca
     1141 caagactggc tgatacggtc aggaccaagg gcttacgatc cccgatcact atggcagaag
     1201 tggaagcgct catgtcctcc ccgttgctgc cgcatgacgt cacgaatcta atgagagtta
     1261 ttttaggacc tgccccatat gccttatgga tggacgcttg gggagtccaa ctccagacgg
     1321 ttatagcggc agccactcgc gacccccgac acccagcgaa cggtcaaggg cggggggaac
     1381 ggactaactt ggatcgatta aagggcttag ctgatgggat ggtgggcaac ccacagggtc
     1441 aggccgcatt attaagaccg ggggaattgg ttgctattac ggcgtcggct ctccaggcgt
     1501 ttagagaagt tgcccggctg gcggaacctg caggtccatg ggcggacatc acgcagggac
     1561 catctgagtc ctttgttgat tttgccaatc ggcttataaa ggcggttgag gggtcagatc
     1621 tcccgcctac cgcgcgggct ccggtgatta ttgactgctt taggcagaag tcgcagccag
     1681 acattcagca gcttatacgg gcagcaccct ccacactgac caccccagga gagataatca
     1741 aatatgtgct ggataggcag aaaactgccc ctcttacgga tcaaggcata gccgcggcca
     1801 tgtcgtctgc tatccagccc ttagttatgg cagtagtcaa tagagagagg gatggacaaa
     1861 ctgggtcggg tggtcgtgcc cgagggctct gctacacttg tggatccccg ggacattatc
     1921 aggcacagtg cccgaaaaaa cgaaaatcag gaaacagccg tgagcgatgt cagctgtgtg
     1981 acgggatggg acacaacgct aaacagtgta ggaagcggga tggcaaccag ggccaacgcc
     2041 caggaagagg tctctcttcg gggccgtggc ccggccctga gcagcctgcc gtctcgttag
     2101 cgatgacaat ggaacataaa gatcgcccct tggttagggt cattctgact aacactggga
     2161 gtcatccagt caaacagcgt tcggtgtata tcaccgcgct gttggactcc ggagcagaca
     2221 tcactattat ttcggaggag gattggccta ctgattggcc ggtggtggac accgcgaacc
     2281 cacagatcca tggcatagga gggggaattc ccatgcgaaa atctcgtgac atgatagagt
     2341 tgggggttat taaccgagac gggtccttgg agcgacccct gctcctcttc cccgcagtgg
     2401 ctatggttag agggagtatc ctaggaagag attgtctgca gggcctaggg ctccgcttga
     2461 caaatttata gggagggcca ctgttcttac tgttgcgcta catctggcta ttccgctcaa
     2521 atggaagcca gaccacacgc ctgtgtggat tgaccagtgg ccccttcctg agggtaaact
     2581 tgtagcgcta acgcaattag tggaaaaaga attgcagcta ggacatatag aaccttcact
     2641 tagttgttgg aacacacctg tctttgtgat ccggaaggct tccgggtctt atcgcttatt
     2701 gcatgacttg cgcgctgtta acgctaagct tgttcctttt ggggccgtcc aacagggggc
     2761 gccagttctc tccgcgctcc cgcgtggctg gcccctgatg gtcctagacc tcaaggattg
     2821 cttcttctct attcctcttg cggaacaaga tcgcgaagct tttgcattta cgctcccctc
     2881 tgtgaataac caggcccccg ctcgaagatt ccaatggaag gtcttgcccc aaggaatgac
     2941 ctgttctccc actatctgtc agttggtagt gggtcaggta cttgagccct tgcgactcaa
     3001 gcacccatct ctgcgcatgt tgcattatat ggatgatctt ttgctagccg cctcaagtca
     3061 tgatgggttg gaagaggcag gggaggaggt tatcagtaca ttggaaagag ccgggttcac
     3121 catttcgcct gataaggtcc agagggagcc cggagtacaa tatcttgggt acaagttagg
     3181 cagtacgtat gtagcacccg taggcctggt agcagaaccc aggatagcca ccttgtggga
     3241 tgttcaaaag ctggtagggt cacttcagtg gcttcgccca gcgttaggaa tcccgccacg
     3301 actgatgggc cccttctatg agcagttacg agggtcagat cctaacgagg cgagggaatg
     3361 gaatctagac atgaaaatgg cctggaggga gatcgtacag cttagcacca ctgctgcctt
     3421 ggaacgatgg gaccctgccc tgcctttgga gggagcggtc gctaggtgtg aacagggggc
     3481 aataggggtc ctgggacagg gactgtccac acacccaagg ccatgtttgt ggctattttc
     3541 cacccaaccc accaaggcgt ttactgcctg gatagaagta ctcacccttt tgattactaa
     3601 gctacgcgct tcggcagtgc gaacctttgg caaggaggtt gatatcctcc tgttgcctgc
     3661 atgctttcgg gaggaccttc cgctcccgga ggggatcctg ttagccctta gggggtttgc
     3721 aggaaaaatc aggagtagtg acacgccatc tatttttgac attgcgcgtc cactgcatgt
     3781 ttctctgaaa gtgagggtca ccgaccaccc tgtaccggga cccactgcct ttaccgacgc
     3841 ctcctcaagc acccataaag gggtggtagt ctggagggag ggcccaaggt gggagataaa
     3901 agaaatagct gatctggggg caagtgtaca acaactggaa gcacgcgctg tggccatggc
     3961 acttttgctg tggccgacaa cgcccactaa tgtagtgact gactccgcgt ttgttgcgaa
     4021 aatgttactc aagatgggtc aggagggagt cccatctaca gcggcggctt ttattttaga
     4081 ggatgcgtta agccaaaggt cagccatggc cgccattctc catgtgcgga gtcattctga
     4141 agtgccaggg tttttcacag aaggaaatga cgtggcagac agccaagcca cctttcaagc
     4201 gtatcccttg agagaggcta aagatcttca tactgctctc catattggac cccgcgcgct
     4261 atccaaagcg tgtaatatat ctatgcagca ggctagggag gttgttcaga cctgcccgca
     4321 ttgtaattca gcccctgcgt tggaggccgg agtaaaccct aggggtttgg gacccctaca
     4381 gatatggcag acagacttta cgcttgagcc tagaatggcc ccccgttcct ggctcgctgt
     4441 tactgtggat accgcctcat cagcgatagt cgtaactcag catggccgtg tcacatcggt
     4501 tgctgcacaa catcattggg ccacggctat cgccgttttg ggaagaccaa aggccataaa
     4561 aacagataat gggtcctgtt tcacgtctaa atccacgcga gagtggctcg cgagatgggg
     4621 gatagcacac accaccggga ttccgggtaa ttcccagggt caagctatgg tagagcgggc
     4681 caaccggctc ctgaaagata agatccgtgt gcttgcggag ggggacggct ttatgaaaag
     4741 aatccccgcc agcaagcagg gggaactact agccaaggca atgtatgccc tcaatcactt
     4801 tgagcgtggt gaaaacacaa aaacaccgat tcaaaaacac tggagaccta ccgttcttac
     4861 agaaggaccc ccggttaaaa tacgaataga gacaggggag tgggaaaaag gatggaatgt
     4921 gctggtctgg ggacgaggtt atgcagctgt gaaaaacagg gacactgata aggttatttg
     4981 ggtaccctct cggaaagtta aaccggatgt cacccaaaag gatgaggtga ctaagaaaga
     5041 tgaggcgagc cctctttttg caggcatttc tgactggata ccctgggaag acgagcaaga
     5101 aggactccaa ggagaaaccg ctagcaacaa gcaagaaaga cccggagaag acacccttgc
     5161 agccaacgag agttaattat attctcatta ttggtgtcct ggtcttgtgt gaggttacgg
     5221 gggtaagagc tgatgtccac ttactcgagc agccagggaa cctttggatt acatgggcca
     5281 accgtacagg ccaaacggat ttttgcctct ctacacagtc agccacctcc ccttttcaaa
     5341 catgtttggt aggtatcccg tcccctattt ccgaaggtga ttttaaggga tacgtctctg
     5401 ataattgcac caccttggga actgaccggt tagtctcgtc agccagcatt accggcggtc
     5461 ctgacaacag caccaccctc acttatcgaa aggtttcatg cttgctgtta aagctgaacg
     5521 tctctatgtg ggatgagcca cctgaactgc agctgttagg ctcccagtct ctccctaata
     5581 tcgctaatat tactcagatc cctggtgtgg caggaggatg cataggcttc accccatacg
     5641 gcagtccggc tggtgtttac gggtggggcc gggaagaggt gacacacatc ctcttaacca
     5701 acccccctga taatcctttc tttaaccgtg cttctaactc cacggaaccg tttacggtgg
     5761 tgacagcgga taggcacaat cttttcatgg ggagcgaata ctgtggtgcg tatggatata
     5821 gattttggga aatgtacaat tgctcacaaa ttcgcaatta ttctatctgt gaggacgtat
     5881 ggggcccagg cctccctgaa aattggtgcg cacgcacggg gggtacatgg gttaataagt
     5941 caaaggaaat caatgagact gagccgatca gctttacggt aaattgtaca ggcagtaatt
     6001 taggcaatgt tagcggatgc tgtggagaag caattacgat tctcccccca ggagcatggg
     6061 tcgacagcac acaaggtagt ttcactaaac ccaaagcgct accacccgga attttcctca
     6121 tttgtgggga tcgcgcatgg caaggaattc ccagtcgtcc ggtagggggc ccctgctatt
     6181 taggcaagct taccatgtta gcacctaacc atacagatat tctcaagata cttgccaatt
     6241 catcacggac aaatgtaaga cgcaaacgaa gcgtctcgca cttggatgat acatgctcag
     6301 atgaagtgca gctttggggt cctacagcaa gaatctttgc atctatctta gccccggggg
     6361 tagcagctgc gcaagcctta agagaaattg agagactagc ctgttggtcc gttaaacagg
     6421 ctaacttgac aacatcactc ctcggggact tattgaatga tgtcacgagt attcgacacg
     6481 cggtcctgca gaaccgagcg gctattgact tcttgctcct agctcacggc catggctgtg
     6541 aggacgttgc cggaatgtgt tgtttcaatc tgagtaatca cagtgagtct atacagaaga
     6601 agttccagct aatgaaggaa catgtcaata agatcggcgt ggacagcgac ccaattggaa
     6661 gttggctgcg aggactattc gggggaatag gagaatgggc cgttcatttg ctgaaaggac
     6721 tgcttttggg gcttgtagtt attttgttgc tagtagtgtg cctgccttgc cttttgcaaa
     6781 tcgtatgcgg tagcatcaga aagatgatta ataactccat cagctaccac acggaatata
     6841 agaagctgca aaaggcctgt gggcaacctg aaagcagaat agtataaggc agtacatggg
     6901 tggtggtata gcgcttgcga gtcgggttgt aacggggcat ggcttaacta aggggactat
     6961 ggcatgtata ggcgcaaagc ggggtttcgg ttgtacgcga ttaggagtcc ccttaggata
     7021 tagtagacac gcttttgcat atgttacata acttccctgt tttgccctta gactattcaa
     7081 gttgcctctg tggattaggg ctggagacag ctcggatggt ctgacggcca gataaggcag
     7141 gaaagacagc tattggtaat tgtgaaatac gcttttgtct gtgtgctgca ggagctgagc
     7201 tgactctgct ggtggcctca cgtaccactg tggccaggca gtagctggga cgtgcagccg
     7261 accaccatgg ggagtagcaa gagcaagcct aaggacccca gccagcgccg gcgcagcctg
     7321 gagccacccg acagcaccca ccacggggga ttcccagcct cgcagacccc caacacgaca
     7381 gcagcccccg acacgcaccg cacccccagc cgctccttcg ggaccgtggc caccgagccc
     7441 aagctcttcg gggacttcaa cacttctgac accgttacgt caccgcagcg tgccggggca
     7501 ctggctggcg gcgtcaccac tttcgtggct ctctacgact acgagtcctg gattgaaacg
     7561 gacttgtcat tcaagaaagg agaacgcctg cagattgtca acaacacgga aggcaactgg
     7621 tggctggctc attccgtgac tacaggacag acgggctaca tccccagtaa ctatgtcgcg
     7681 ccctcagact ccatccaggc tgaagagtgg tactttggga agatcactcg tcgggagtcc
     7741 gagcggctgc tgctcaaccc cgaaaacccc cggggaacct tctcggtccg ggagagcgag
     7801 acgacaaaag gtgcctattg cctctccgtt tctgactttg acaacgccaa ggggctcaat
     7861 gtgaagcact acaagatccg caagctggac agcggcggct tctacatcac ctcacgcaca
     7921 cagttcagca gcctgcagca gctggtgacc tactactcca aacatgctga tggcttgtgc
     7981 caccgcctga ccaacgtctg ccccacgtcc aagccccaga cccagggact cgccaaggac
     8041 gcgtgggaaa tcccccggga gtcgctgcgg ctggaggtga agctggggca gggctgcttt
     8101 ggagaggtct ggatggggac ctggaacggc accaccagag tggccataaa gactctgaag
     8161 cccggcacca tgtccccgga ggccttcctg caggaagccc aagtgatgaa gaagctccag
     8221 catgagaagc tggttcaact gtacgcagtc gtgtcggaag agcccatcta catcgtcatt
     8281 gagtacatga gcaaggggag cctcctgaat ttcctgaagg gagagatggg caagtacctg
     8341 cggctgccac agctcgttga tatggctgct cagattgcat ccagcatggc ctatgtggag
     8401 aggatgaact acgtgcaccg agacctgcgg gcggccaaca tcctggtggg ggagaacctg
     8461 gtgtgcaagg tggctgactt tgggctggca cgcctcatcg aggacaacga gtacacagca
     8521 cggcaaggtg ccaagttccc catcaagtgg acagcccccg aggcagccct ctatggccgg
     8581 ttcaccatca agtcggatgt ctggtccttc ggcatcctgc tgactgagct gaccaccaag
     8641 ggccgggtgc catacccagg gatgggcaac ggggaggtgc tggaccgggt ggaggagggc
     8701 taccgcatgc cctgcccgcc cgagtgcccc gagtcgctgc atgaccttat gtgccagtgc
     8761 tggcggaggg accctgagga gcggcccact tttgagtacc tgcaggccca gctgctccct
     8821 gcttgtgtgt tggaggtcgc tgagtagtgc gcgagcaaaa tttaagctac aacaaggcaa
     8881 ggcttggccg acaattgcat gaagaatctg cttagggtta ggcgttttgc gctgcttcgc
     8941 gatgtacggg ccagatatac gcgtatctga ggggactagg gtgtgtttag gcgaaaagcg
     9001 gggcttcggt tgtacggggt taggagtccc ctcaggatat agtagtttcg cttttgcata
     9061 gggaggggga aatgtagtct tatgcaatac tcttgcaaca tgcttatgta acgatgagtt
     9121 agcaacatgc cttacaagga gagaaaaagc accgtgcatg acgattggtg gaagtaaggt
     9181 ggtacgatcg tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca
     9241 ctgaattccg cattgcagag atattgtatt taagtgccta gctcgataca ataaacgcca
     9301 tttgaccatt caccaca
//