From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: TIS10=prostaglandin synthase/cyclooxygenase homolog [mice, Swiss,
Date: 21 Dec 92 20:52:33 GMT
Distribution: bionet
Checksum: 37029 8

LOCUS       S41933       4012 bp    mRNA            NLM       18-NOV-1992
DEFINITION  TIS10=prostaglandin synthase/cyclooxygenase homolog [mice, Swiss,
            3T3 cells, mRNA, 4012 nt]
ACCESSION   S41933
KEYWORDS    .
SOURCE      mice Swiss 3T3 cells
  ORGANISM  Unclassified.
            Unclassified.
REFERENCE   1  (bases 1 to 4012)
  AUTHORS   Kujubu,D.A., Fletcher,B.S., Varnum,B.C., Lim,R.W. and
            Herschman,H.R.
  TITLE     TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3
            cells, encodes a novel prostaglandin synthase/cyclooxygenase
            homologue.
  JOURNAL   J. Biol. Chem. 266, 12866-12872 (1991)
  STANDARD  full automatic
COMMENT     This entry incorporates information provided by the National
            Library of Medicine's GenInfo Backbone as NCBI gibbsq 41933.
            This sequence comes from Fig. 1.  The authors begin their numbering
            at -26.  Zero is not present in the numbering.
FEATURES             Location/Qualifiers
     CDS             151..1965
                     /note="Description: prostaglandin synthase/cyclooxygenase
                     homolog;  For the protein sequence (NCBI gibbsq 41936):
                     This sequence comes from Fig. 1."
                     /gene="TIS10"
                     /codon_start=1
                     /translation="MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDC
                     TRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLTMKYV
                     LTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDS
                     KEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNH
                     IYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQE
                     VFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDY
                     VQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQ
                     FLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLN
                     EYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETM
                     VELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSF
                     NVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL"
BASE COUNT     1177 a    862 c    814 g   1159 t
ORIGIN      
        1 aagcaaggtt ctccccatta gcagccagtt gtcaaactgc gagctaagag cttcaggagt
       61 cagtcaggac tctgctcacg aagaatctca gcactgcatc ctgccagctc caccgccacc
      121 accactgcca cctccgctgc cacctctgcg atgctcttcc gagctgtgct gctctgcgct
      181 gccctggggc tcagccaggc agcaaatcct tgctgttcca atccatgtca aaaccgtggg
      241 gaatgtatga gcacaggatt tgaccagtat aagtgtgact gtacccggac tggattctat
      301 ggtgaaaact gtactacacc tgaatttctg acaagaatca aattactgct gaagcccacc
      361 ccaaacacag tgcactacat cctgacccac ttcaagggag tctggaacat tgtgaacaac
      421 atccccttcc tgcgaagttt aactatgaaa tatgtgctga catccagatc atatttgatt
      481 gacagtccac ctacttacaa tgtgcactat ggttacaaaa gctgggaagc cttctccaac
      541 ctctcctact acaccagggc ccttcctcca gtagcagatg actgcccaac tcccatgggt
      601 gtgaagggaa ataaggagct tcctgattca aaagaagtgc tggaaaaggt tcttctacgg
      661 agagagttca tccctgaccc ccaaggctca aatatgatgt ttgcattctt tgcccagcac
      721 ttcacccatc agtttttcaa gacagatcat aagcgaggac ctgggttcac ccgaggactg
      781 ggccatggag tggacttaaa tcacatttat ggtgaaactc tggacagaca acataaactg
      841 cgccttttca aggatggaaa attgaaatat caggtcattg gtggagaggt gtatcccccc
      901 acagtcaaag acactcaggt agagatgatc taccctcctc acatccctga gaacctgcag
      961 tttgctgtgg ggcaggaagt ctttggtctg gtgcctggtc tgatgatgta tgccaccatc
     1021 tggcttcggg agcacaacag agtgtgcgac atactcaagc aggagcatcc tgagtggggt
     1081 gatgagcaac tattccaaac cagcagactc atactcatag gagagactat caagatagtg
     1141 atcgaagact acgtgcaaca cctgagcggt taccacttca aactcaagtt tgacccagag
     1201 ctccttttca accagcagtt ccagtatcag aaccgcattg cctctgaatt caacacactc
     1261 tatcactggc accccctgct gcccgacacc ttcaacattg aagaccagga gtacagcttc
     1321 aaacagtttc tctacaacaa ctccatcctc ctggaacatg gactcactca gtttgttgag
     1381 tcattcacca gacagattgc tggccgggtt gctgggggaa gaaatgtgcc aattgctgta
     1441 caagcagtgg caaaggcctc cattgaccag agcagagaga tgaaatacca gtctctcaat
     1501 gagtaccgca aacgcttctc cctgaagccg tacacatcat ttgaagaact tacaggagag
     1561 aaggaaatgg ctgcagaatt gaaagccctc tacagtgaca tcgatgtcat ggaactgtac
     1621 cctgccctgc tggtggaaaa acctcgtcca gatgctatct ttggggagac catggtagag
     1681 cttggagcac cattctcctt gaaaggactt atgggaaatc ccatctgttc tcctcaatac
     1741 tggaagccga gcacctttgg aggcgaagtg ggttttaaga tcatcaatac tgcctcaatt
     1801 cagtctctca tctgcaataa tgtgaagggg tgtcccttca cttctttcaa tgtgcaagat
     1861 ccacagccta ccaaaacagc caccatcaat gcaagtgcct cccactccag actagatgac
     1921 attaacccta cagtactaat caaaaggcgt tcaactgagc tgtaaaagtc tactgaccat
     1981 atttatttat ttatgtgaag gaatttaatt taattattta atatttatac tgaatttttt
     2041 ttcatgtaac atcttccata acagaaggca atgttcttga acaatgttac atttgtgaag
     2101 attcctccgg tgtttgtcct ttaaatatgt gttacctgaa actgaaagga aatcagcatt
     2161 cattcctcta cataagccag tgagaaggga aatgaatttt gatatcttta tacttgaatt
     2221 tcagatcatg aattagctta acaagaacca aggaaaaatg tatgaatatg tgagtgttgt
     2281 tacaagatga aaaatgctgc aggtatcaac actgttggtt acactgtgtc ttctttacct
     2341 atgataggag catgtaatgt ggaattcgtc ttaaatcctt gcatatcttt atctcatcaa
     2401 acaaaggggt ccaagttcag ttttaaataa gcatttaagg cagatactga caacaatctc
     2461 atttttttaa aatgttgtct tgagacaaat aatttgaaat ttctaaattg ggacgtttga
     2521 atcacttttg aaagctctta ctttcttaag ctgtcaggtt tgtaccgaca tggagtaaac
     2581 agctatcata aacgtaaatc tccaaaacta gtagaaatta tgtcatgatt gatggttaag
     2641 ataccatgtc agggattgtc ttttcttaga agtagtgaaa gctacttact atgacaatca
     2701 gaccttcctt gtatgtcaaa atgctggtgt ggaaggtggt ggagcccgtg ctgctctgtc
     2761 ttaactatga gtgtgagctt taaagctcgt tgatgagtgg tagccagcaa agcctagagc
     2821 aacaaaagcg ttctacaaag gaactaacca agaacaaaga agggttccca attaaagatc
     2881 acattcaggg ttaaacttcc aaaggagaca tcctgatcct ggttttgtgc tggcctggta
     2941 ctcagtaggt ttttgctgtg aggttaaaga cttgccaggg ctgaacttcg aaacagtttt
     3001 tctgttgcac agtatgatgt aacagtccat ctctcaatgc aataggtatc agtggcctcg
     3061 tgagcttctt cacaatattt gatatgtctt ccagcccatt gaacctggac tgcagaaggc
     3121 cccatgtcat gtgtgagctc agcctggatg ccagcatttg ctgctcctct tagttccgtt
     3181 tctcgtggtc actttactac gagaaacgct gattgggttt tcgtagctgt gttaccaggt
     3241 ttttagtatc agaactattc tttctttaac ctctattcat attttctcta cttgaagttt
     3301 tacattcagg aaaacctcag cgctcaggac tactatgtac ctcccctttg gagggaaaaa
     3361 ttcattttta ggtaaaaggc aaaaattttt taaaaatatt ttttatttat aattatatgg
     3421 aagggcccta ccaagatgct agaaatatag ggagttcctg acaagaaatt tccattctta
     3481 ttctgaagaa ttgctttctt acttaaaaac aaagacagtt tgtgagtagt tctgggcaat
     3541 agggataaat ataaaacaat aatgatgatc attttctaca tctcattatc agctgaggta
     3601 ctgtatatta ctgaatttat tgaagatagt tatgtctttt agacattgtt gttataaact
     3661 atgtttaagc ctactacaag tgtttctttt ttgcattatg ttggaattga tgtacctttt
     3721 ttatgattac ctctctgaac tatggtgtga acaatcaaac aaaatgatga gattaacgtt
     3781 catggataaa ttctaagaaa actagtgtat ttttttgaaa agtttgaagt tagaacttag
     3841 gctgttggaa tttacgcata aagcagactg cataggatcc aatattgact gacccaagca
     3901 tgttataaag actgacattt tagacatttt gaaggccctg taagtgttta ttaattagtt
     3961 agaacttaat tgattaaaaa atatatccaa agcactatag gcattagaat tc
//