From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human immunophilin (FKBP52) mRNA, complete cds.
Date: 28 Dec 92 21:29:41 GMT
Distribution: bionet
Checksum: 59235 6

LOCUS       HUMIMMPHLN   2156 bp ss-mRNA            PRI       01-DEC-1992
DEFINITION  Human immunophilin (FKBP52) mRNA, complete cds.
ACCESSION   M88279
KEYWORDS    FK506 binding protein; immunophilin.
SOURCE      Homo sapiens placenta cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Sanchez,E.R., Faber,L.E., Henzel,W.J. and Pratt,W.B.
  TITLE     The 56-59-kilodalton protein identified in untransformed steroid
            receptor complexes is a unique protein that exists in cytosol in a
            complex with both the 70- and 90-kilodalton heat shock proteins
  JOURNAL   Biochemistry 29, 5145-5152 (1990)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Yem,A.W., Tomasselli,A.G., Heinrikson,R.L., Zurcher-Neely,H.,
            Ruff,V.A., Johnson,R.A. and Deibel,M.R.
  TITLE     The hsp56 component of steroid receptor complexes binds to
            immobilized FK506 and shows homology to FKBP-12 and FKBP-13
  JOURNAL   J. Biol. Chem. 267, 2868-2871 (1992)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Benasutti,M., Harding,M.W., Fleming,M.A., DeCenzo,M.T.,
            Lippke,J.A., Livingston,D.J. and Peattie,D.A.
  TITLE     Expression and characterization of human FKBP52, an immunophilin
            that associates with the 90-kDa heat shock protein and is a
            component of steroid receptor complexes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 10974-10978 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..99
     3'UTR           1480..2156
     polyA_signal    2143..2148
     polyA_site      2156
     CDS             100..1479
                     /function="'binds the immunosuppressants FK506 and
                     rapamycin'"
                     /product="immunophilin"
                     /codon_start=1
                     /translation="MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGT
                     EMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEV
                     CHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEG
                     YAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSI
                     VYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKER
                     GTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQA
                     FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQ
                     LAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAG
                     SQSQVETEA"
BASE COUNT      530 a    551 c    606 g    469 t
ORIGIN      
        1 cccggcctcc cgcacgcccc gcaggtagcg cccccgcccg cggcccagag tgcgctcgcg
       61 ccggcaccag ctcccggata aacggcgcgc cgcgcggaga tgacagccga ggagatgaag
      121 gcgaccgaga gcggggcgca gtcggcgccg ctgcccatgg agggagtgga catcagcccc
      181 aaacaggacg aaggcgtgct gaaggtcatc aagagagagg gcacaggtac agagatgccc
      241 atgattgggg accgagtctt tgtccactac actggctggc tattagatgg cacaaagttt
      301 gactccagtc tggatcgcaa ggacaaattc tcctttgacc tgggaaaagg ggaggtcatc
      361 aaggcttggg acattgccat agccaccatg aaggtggggg aggtgtgcca catcacctgc
      421 aaaccagaat atgcctacgg ttcagcaggc agtcctccaa agattccccc caatgccacg
      481 cttgtatttg aggtggagtt gtttgagttt aagggagaag atctgacgga agaggaagat
      541 ggcggaatca ttcgcagaat acagactcgc ggtgaaggct atgctaagcc caatgagggt
      601 gctatcgtgg aggttgcact ggaagggtac tacaaggaca agctctttga ccagcgggag
      661 ctccgctttg agattggcga gggggagaac ctggatctgc cttatggtct ggagagggcc
      721 attcagcgca tggagaaagg agaacattcc atcgtgtacc tcaagcccag ctatgctttt
      781 ggcagtgttg ggaaggaaaa gttccaaatc ccaccaaatg ctgagctgaa atatgaatta
      841 cacctcaaga gttttgaaaa ggccaaggag tcttgggaga tgaattcaga agagaagctg
      901 gaacagagca ccatagtgaa agagcggggc actgtgtact tcaaggaagg taaatacaag
      961 caagctttac tacagtataa gaagatcgtg tcttggctgg aatatgagtc tagtttttcc
     1021 aatgaggaag cacagaaagc acaggccctt cgactggcct ctcacctcaa cctggccatg
     1081 tgtcatctga aactacaggc cttctctgct gccattgaaa gctgtaacaa ggccctagaa
     1141 ctggacagca acaacgagaa gggcctcttc cgccggggag aggcccacct ggccgtgaat
     1201 gactttgaac tggcacgggc tgatttccag aaggtcctgc agctctaccc caacaacaaa
     1261 gccgccaaga cccagctggc tgtgtgccag cagcggatcc gaaggcagct tgcccgggag
     1321 aagaagctct atgccaatat gtttgagagg ctggctgagg aggagaacaa ggccaaggca
     1381 gaggcttcct caggagacca tcccactgac acagagatga aggaggagca gaagagcaac
     1441 acggcaggga gccagtctca ggtggagaca gaagcatagc ccctctccac cagccctact
     1501 cctgcggctg cctgcccccc agtctcccca ctccaccctg ttagttttgt aaaaactgaa
     1561 gaattttgag tgaattagac ctttattttt ctatctggtt ggatggtggc tttaggggaa
     1621 gggggaaagg tgtaggctgg gggattgagg tggggaatca ttttagctgg tgtcagcccc
     1681 tcttcccttc ctccattgca catgaacata tgtccatcca tatatattca tcagaatgtt
     1741 aatttatttt gctccctctg ttaggtccat tttctaaggg tagaagaggc aagtggtagg
     1801 gatgaggtct gataagaacc cagggtggag agggagactc ctgggcagcc gttttcctca
     1861 tcctttccct ctcccagtcc atttccaaat gtggcctcca tgtgggtgct agggacatgg
     1921 gaaaaaccac tgctatgcca tttcttctct ctgttccctt cctcaccccc gacggtgtgg
     1981 ctgatgatgt cttctggtgt catggtgacc accccctgtt ccctgttctg gtatttcccc
     2041 tgtcagtttc ccctctcggc caggttgtgt cccaaaatcc cctcagcctc ttctctgcac
     2101 gttgctgaag gtccaggctt gcctcaagtt ccatgcttga gcaataaagt ggaaac
//