From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human Ig germline H-chain (V71-4) gene V-region, exons 1 and 2.
Date: 12 Sep 92 10:02:35 GMT
Distribution: bionet
Checksum: 19187     4

LOCUS       HUMIGHVV4    1199 bp ds-DNA             PRI       12-SEP-1992
DEFINITION  Human Ig germline H-chain (V71-4) gene V-region, exons 1 and 2.
ACCESSION   M29812
KEYWORDS    constant region; germline; immunoglobulin heavy chain;
            variable region.
SEGMENT     4 of 7
SOURCE      Homo sapiens placenta DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Kodaira,M., Kinashi,T., Umemura,I., Matsuda,F., Noma,T., Ono,Y. and
            Honjo,T.
  TITLE     Organization and evolution of variable region genes of the human
            immunoglobulin heavy chain
  JOURNAL   J. Mol. Biol. 190, 529-541 (1986)
  STANDARD  simple staff_review
FEATURES             Location/Qualifiers
     CDS             join(151..196,279..581)
                     /gene="IGH@"
                     /codon_start=1
                     /translation="MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVS
                     GGSVSSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLS
                     SVTAADTAVYYCAR"
                     /partial
     sig_peptide     join(151..196,279..289)
                     /gene="IGH@"
                     /codon_start=1
     intron          197..278
                     /gene="IGH@"
     exon            279..581
                     /number=2
                     /gene="IGH@"
     mat_peptide     290..582
                     /gene="IGH@"
                     /codon_start=1
                     /partial
     iDNA            583..>1199
                     /note="V-D intervening DNA (5' end put.)"
                     /gene="IGH@"
                     /note="putative"
BASE COUNT      297 a    308 c    302 g    292 t
ORIGIN      About 4.0 kb after segment 3.
        1 cctccttttt cacctctcca tacaaaggca ccacccacat gcaaatcctc acttaagcac
       61 ccacaggaaa ccaccacaca tttccttaaa ttcaggttcc agctcacatg ggaaatactt
      121 tctgagagcc tggacctcct gtgcaagaac atgaaacatc tgtggttctt ccttctcctg
      181 gtggcagctc ccagatgtga gtatctcagg gatccagaca tggggatatg ggaggtgcct
      241 ctgatcccag ggctcactgt gggtctctct gttcacaggg gtcctgtccc aggtgcagct
      301 gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcactgt
      361 ctctggtggc tccgtcagta gttactactg gagctggatc cggcagcccc cagggaaggg
      421 actggagtgg attgggtata tctattacag tgggagcacc aactacaacc cctccctcaa
      481 gagtcgagtc accatatcag tagacacgtc caagaaccag ttctccctga agctgagctc
      541 tgtgaccgct gcggacacgg ccgtgtatta ctgtgcgaga gacacagtga ggggaggtga
      601 gtgtgagccc agacaaaaac ctccgtcagg gaggcggagg ggacccgcaa ggtgctgctc
      661 agaccagcag gcgcggggcc cacagagcag gaggcccggt caggacaggt gcagggaggg
      721 cggggcttcc tcatctgctc agtggtctcc ctcctcgcca gcacctcgct gtccccaggg
      781 gtcctctttc tttattatct gtggttctgc ttcctcacat tcttgtgcca agaaagaaat
      841 gaggaagaca aattttcgtc tatagttgaa gtttcaccaa ttactaggaa ctttcctaga
      901 agttcctgca tggcccatta tagcttacag attaaatata tatcaagctt ctcatctctt
      961 gattgtgtca tcaactgaat tgtgccctct ttgaaattca tatgcagaaa ccttaaattc
     1021 aattgatgta tattggaatt ttaatgaaat aattaaggtt aaatgtggtc ataagtgtaa
     1081 gactctaatt caacagacgt gtcgtcttta taagaagagg aagagacacc agagacctct
     1141 cacttttcac gtgcaggcag agaagaggcc atgtggagac atagtgcact ggaaggtgg
//