From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse T-cell-specific tyrosine kinase (Itk) mRNA, complete cds.
Date: 3 Jan 93 22:25:59 GMT
Distribution: bionet
Checksum: 40033 8

LOCUS       MUSITKA      4294 bp ss-mRNA            ROD       24-DEC-1992
DEFINITION  Mouse T-cell-specific tyrosine kinase (Itk) mRNA, complete cds.
ACCESSION   L00619
KEYWORDS    T-cell specific tyrosine kinase; interleukin induced gene.
SOURCE      Mus musculus cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Siliciano,J.D., Morrow,T.A. and Desiderio,S.V.
  TITLE     Itk, a T cell-specific tyrosine kinase gene inducible by
            interleukin-2
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           10..92
                     /gene="Itk"
     3'UTR           1971..4265
                     /gene="Itk"
     CDS             93..1970
                     /gene="Itk"
                     /note="interleukin-2 inducible"
                     /product="T-cell-specific tyrosine kinase"
                     /codon_start=1
                     /translation="MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDR
                     HGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDC
                     ESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSKNASK
                     KPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQ
                     DKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTP
                     GTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGG
                     LVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDK
                     VAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD
                     YLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGM
                     TRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN
                     RSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIAEAG
                     L"
BASE COUNT     1128 a   1071 c   1044 g   1051 t
ORIGIN      
        1 gaattccgtt cctgtctcag tctccgctgc tcctctcctt cagtcgcact gcggggtgat
       61 gcccaaggcg catcactttt cagaactgga ccatgaacaa cttcatcctc ctggaagaac
      121 agctgatcaa gaagtcccaa cagaagagaa ggacttctcc ctcgaatttt aaagttcgtt
      181 tctttgtctt aacgaaagcc agcctggcct actttgagga ccgccacggg aagaagcgca
      241 cgttgaaggg ctccattgaa ctctccagaa tcaagtgtgt ggagattgtc aagagtgaca
      301 ttagcatccc gtgccactat aaataccctt ttcagactct tgtgtactta caggtcgtgc
      361 atgacaacta tctcctgtat gtgtttgctc cagactgtga gagtcggcag cgctgggtgc
      421 tgacccttaa agaagaaacg aggaataaca acagcctggt atccaagtat caccctaatt
      481 tctggatgga tgggcggtgg aggtgctgct cccagctgga gaagcctgct gtaggctgtg
      541 ctccctacga cccatccaag aatgcttcaa agaagcctct tcctcctact cctgaagaca
      601 acaggcggtc atttcaggaa cctgaagaaa ccctggtcat tgccttgtac gactaccaaa
      661 ccaacgaccc tcaggagctc gcgctgcggt gtgatgaaga gtactacctg ctggacagct
      721 ccgagatcca ctggtggagg gttcaagaca aaaatgggca tgaaggatat gcaccaagca
      781 gttacctggt agaaaaatct ccaaataacc ttgaaaccta tgagtggtac aataaaagca
      841 tcagccgcga caaagctgaa aaacttcttt tggacacagg taaagaagga gctttcatgg
      901 tccgagattc caggacgccc gggacataca cagtctctgt tttcaccaag gccatcataa
      961 gtgagaaccc ctgtataaaa cattatcaca tcaaagaaac aaatgacagc cccaagcgct
     1021 actacgtggc tgagaagtat gtgtttgact ccatccctct cctcatccag tatcaccagt
     1081 acaatggagg aggtttggtc actcgactcc gctatccagt ttgctcctgg agacaaaaag
     1141 cccctgtcac agcagggcta agatatggga agtgggtgat ccaaccctca gagctaacgt
     1201 tcgtgcagga gattggcagc gggcagtttg ggctggtgca tctcggctac tggctcaaca
     1261 aggacaaggt ggccatcaag accattcagg aaggggcgat gtcagaagaa gactttatcg
     1321 aggaggcgga agtcatgatg aaactctctc accccaaact ggtgcagctc tatggggtgt
     1381 gcctggagca agcccccatc tgcctggtgt ttgagttcat ggagcacggc tgcctgtcgg
     1441 attaccttcg aagtcagcgg ggtctctttg ctgcggagac cctgctgggc atgtgcctgg
     1501 atgtgtgtga gggcatggcc tacctggaaa aagcttgtgt catccacaga gacctggcag
     1561 ccagaaactg tttggtggga gaaaaccagg tcatcaaggt gtccgacttt gggatgacaa
     1621 gatttgtcct tgatgatcaa tataccagct ccacgggcac caaattccca gtgaagtggg
     1681 catccccaga ggtgttctcc tttagtcgct atagcagcaa gtcagatgtg tggtcgtttg
     1741 gtgtactgat gtgggaagtc ttcagtgaag gcaaaatccc atacgaaaac cgaagcaatt
     1801 ccgaggtcgt ggaagatatc agcactggct ttcggttata caagccccgc ctggcctcct
     1861 gtcatgtcta ccagatcatg aatcattgct ggaaagagaa accagaagac cggccaccct
     1921 tctcccagct gttaagccag ctggctgaaa tcgcagaagc tgggctttag cagggactca
     1981 ttgaccagac acagccataa atcctgagtg aaggaacaat gtcctttttc cagagcatta
     2041 aaagctgcca ccagtccaga aacccccaca ggtgcctgga ccatggtgcc agcacctatg
     2101 cagccacaac tgcagcatca tagaaaaggg tggagggcca gccactgagc caacagctga
     2161 accacaactg gagcagtatc tgcgtgtcac cccatcccag cctcttgtcg tatgctgtac
     2221 tcaaagctcc attgcccact ctgggagcat cccctccccc tcttagcaat ccatggagag
     2281 gcagacgtag gccacactct tctttattat tactttaaga ataattcaag taacctttaa
     2341 tttggcccaa cgagacaatg tgcccatttt atggatggaa gagcgggaaa gcatcattct
     2401 ttttctaaga aatgcaagag gtgattaaac cagggtgttc tactacttca aggctgtcag
     2461 ccacagcttc ctgcctcaca tgaggcggag cggatgcttg tgccagaggc cggatgccat
     2521 aaggtttcag agcacactgc cacctctctt tgatggggca cagagagctc caccgggtgg
     2581 atagggcagg gtgacacatt cagaccccac ggcaggacca caggatgtct gaggtcggtc
     2641 aggaatgaga gggcctctga tggtggaagt aaagagctgc aaaagaagcc tttgggttgt
     2701 ccctgaccca gcggccctgt ttcacggtga gtcatgtgtg tgactggatc tcctgttctg
     2761 tgcaggatgc tgaagcagtg actacagaac ggtcatcatt ccagcctctc aggagcggca
     2821 tccactcagc actgtcatga tccttgtgac tttgagactt tgggttcttt caagccttta
     2881 cgggttcagc agtcttaagg ttgccatgta agctctcaag agcccagcaa aggaagaagg
     2941 cgtttgctct tgcccaaact atcaggaagg aaagaggcaa gcactgggcg gtgcttccaa
     3001 aatgcacaga tgtctcctac tgattggcac tcgcacaggt gacatgtgta tatcctgcac
     3061 acaggtcatc ctggcgaatc acagttcata ccaacccaac cacgaggtat tattcatgtc
     3121 ttacagaaag tggacttggt cttttaaaag ctggatagct gccccagtga cagaactggg
     3181 aaggacggag attgagatga cacccgaata taactccagt gtagcctctt agctcttctc
     3241 aatgctgcct cctactgggt tgggccgctg agcgcataac acaggaaagt ctgggttaat
     3301 gggcacccca ccccacagcc aagttgctcc tactcagagc actggggggc ccagtgggac
     3361 cctccaaatt gaaataggct gttctctttc ttcaccctca cctggatctg agttcacaac
     3421 cctggagcca ctcaaaatta accctttcat tctcccaacc taccagagtc acattgcctg
     3481 aggccattta tactagagct tcaaaggtgc tttcaactag tctcctgcag actgtttcct
     3541 gtaattatcc cttcaaccta gagctggctc tcttgtgaga aggaggattc cctggtgcca
     3601 ggcacactgg attttctgcg gtgttcagac aaagccccta gaaaaatgat cagagtcaca
     3661 gatccctctt cctaagtcac gtggcattta ggctggcttg aggctcaaat gcatcacttc
     3721 caactgtaat cactgtgtcc agataaaact ctgtcattca gaaaatgaac ttcctcaact
     3781 ggtccacaat catctctgtt tattctcttt tgggaaacct taattaagag acgatttctg
     3841 ggacatccaa tctggaagat aaacactgga accgagagaa gtctgtggtg tggtttagga
     3901 gactggcccc catacggtgg tattggctct cttaacctca catgcacgaa ggctttgatg
     3961 gacgcgtgtg cactgcttac tccagtgtcc tgcttgggaa gatgggattc tcttctgctg
     4021 gtttctgtct tacatttttt tgtaaatggt gccctgtgtt cacagaaagg ttttggtttg
     4081 aaatgtattt tgtaggcctt gcaattcata atgtttggaa ctatgtattt atgcctagat
     4141 caggagagta tttattgctt gtcttcatga taaaaaatac tgcaggtatg tcttaccctc
     4201 tgtgggggcc acaagtcaat cattgcttat ggaaaaaaat atatatataa agctacatgt
     4261 tttacaaaaa aaaaaaaaaa aaaaaaagga attc
//