From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens Ig germline lambda-chain gene variable region
Date: 6 Nov 92 18:06:58 GMT
Distribution: bionet
Checksum: 01840 4

LOCUS       HUMIGLVG      771 bp ds-DNA             PRI       28-OCT-1992
DEFINITION  Homo sapiens Ig germline lambda-chain gene variable region
            retinoblastoma subgroup I (IGLV), 5' end cds.
ACCESSION   M94118
KEYWORDS    germline; immunoglobulin light chain; lambda-immunoglobulin;
            promoter region; variable region; variable region subgroup VL-I.
SOURCE      Homo sapiens (library: EMBL-3) retinoblastoma DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 771)
  AUTHORS   Daley,D.M., Olee,T., Peng,H.-q., Soto-Gil,R.W., Chen,P.P. and
            Siminovitch,K.A.
  TITLE     Molecular characterization of the human immunoglobulin V lambda-I
            germline gene repertoire
  JOURNAL   Mol. Immunol. 29, 1031-1042 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     misc_feature    121..735
                     /note="This feature applies to a gene which lacks a coding
                     region feature. "
                     /gene="IGLV"
     sig_peptide     join(235..280,390..400)
                     /gene="IGLV"
                     /codon_start=1
     exon            <235..280
                     /number=X
                     /gene="IGLV"
     CDS             join(235..280,390..694)
                     /pseudo
                     /standard_name="Humlv1041"
                     /product="immunoglobulin lambda-I V-region"
                     /gene="IGLV"
                     /codon_start=1
                     /partial
     promoter        121..128
                     /gene="IGLV"
     TATA_signal     153..159
                     /gene="IGLV"
     intron          281..389
                     /gene="IGLV"
     exon            390..694
                     /number=X+1
                     /gene="IGLV"
     mat_peptide     401..694
                     /pseudo
                     /standard_name="Humlv1041"
                     /product="immunoglobulin lambda-I V-region"
                     /gene="IGLV"
                     /note="putative"
                     /codon_start=1
                     /citation=[1]
     misc_signal     697..703
                     /standard_name="heptamer recombination signal"
                     /gene="IGLV"
                     /note="putative"
                     /citation=[1]
     misc_signal     727..735
                     /standard_name="nonomer recombination signal"
                     /gene="IGLV"
                     /note="putative"
                     /citation=[1]
BASE COUNT      164 a    246 c    202 g    159 t
ORIGIN      
        1 acagatgtca actctgcacc ccctgggacc acatagcccc acccctggca ctctctgaca
       61 tcctcaggca gaggagcctg acccagggcc caaggtggga tcagaaagct ggagggtctg
      121 atttgcatgg ttggaccctc cttctctcag agtataaaga ggggcaggga gagacttggg
      181 gaagctctgc ttcagctgtg agcacagaag gcaggactcg ggacaatctt catcatgacc
      241 tgctcccctc tcctcctcac ccttctcatt cactgcacag gtgcccagac acagggtcag
      301 gggaggggtc caggaagccc atgaggccct gctttctcct tctctctcta gaccaagaat
      361 cactgtgtct gtgtctctcc tgcttccacg gtcctgggcc cagtctgtgt tgacgcagcc
      421 gccttcagtg tctgcggccc caggacagaa ggtcaccatc tcctgctctg gaagcagctc
      481 cgacatgggg aattatgcgg tatcctggta ccagcagctc ccaggaacag cccccaaact
      541 cctcatctat gaaaataata agcgaccctc agggattcct gaccgattct ctggctccaa
      601 gtctggcacc tcagccaccc tgggcatcac tggcctctgg cctgaggacg aggccgatta
      661 ttactgctta gcatgggata ccagcccgag agcttgcaca gtgctccagg ccaatgggga
      721 actgagacaa gaaccccctt cctcctccgc caggagggtg agtgcctgca g
//