From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human putative Cu++-transporting P-type ATPase mRNA, complete cds.
Date: 27 Jan 93 05:47:34 GMT
Distribution: bionet
Checksum: 05760 14

LOCUS       HUMATPCU     8478 bp ss-mRNA            PRI       26-JAN-1993
DEFINITION  Human putative Cu++-transporting P-type ATPase mRNA, complete cds.
ACCESSION   L06133
KEYWORDS    Cu++-transporting ATPase; P-type ATPase.
SOURCE      Homo sapiens (library: cDNA libraries from J. Ellison and J.
            Edmund) fibroblast cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 8478)
  AUTHORS   Vulpe,C.D., Levinson,B., Whitney,S., Packman,S. and Gitschier,J.
  TITLE     Isolation of a candidate gene for Menkes disease and evidence that
            it encodes a copper-transporting ATPase
  JOURNAL   Nature Genet. 3, 7-13 (1993)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     repeat_region   5655..5951
     polyA_site      8478
     CDS             146..4648
                     /note="putative"
                     /product="Cu++-transporting P-type ATPase"
                     /codon_start=1
                     /translation="MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLE
                     EKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDH
                     IQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGAC
                     EDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPH
                     LISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTND
                     STATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKA
                     IVAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCV
                     QSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEP
                     LVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIER
                     NLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVL
                     ELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIES
                     LGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMTYMMVMDHHFATLH
                     HNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALK
                     HKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLE
                     HIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKF
                     PVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLS
                     QIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFP
                     GYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGE
                     PLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPL
                     GTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNAS
                     LVQIDASNEQSSTSSSMIIDAQISNALNAQQHKVLIGNREWMIRNGLVINNDVNDFMT
                     EHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTAR
                     SIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGT
                     GTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFM
                     PIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISV
                     HVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFRE
                     DDDTAL"
BASE COUNT     2520 a   1595 c   1701 g   2662 t
ORIGIN      
        1 gccgcagccg cagctactgt gacttctccg attgtgtgag ctttgttgga gcctgcgtac
       61 gtggatttat cgctgccacg gtctgcgtag ttccagaggt ttaaccatag gatagagaaa
      121 ccaggaatgt aatgaggaaa tcaaaatgga tccaagtatg ggtgtgaatt ctgttaccat
      181 ttctgttgag ggtatgactt gcaattcctg tgtttggacc attgagcagc agattggaaa
      241 agtgaatggt gtgcatcaca ttaaggtatc actggaagaa aaaaatgcaa ctattattta
      301 tgaccctaaa ctacagactc caaagaccct acaggaagct attgatgaca tgggctttga
      361 tgctgttatc cataatcctg accctctccc tgttttaact gacaccttgt ttctgactgt
      421 tacggcgtca ctgactttgc catgggacca tatccaaagc acattgctga agaccaaggg
      481 tgtgacagac attaaaattt accctcagaa aagaactgta gcagtgacaa taatcccttc
      541 tatagtgaat gccaatcaga taaaagagct ggttccagaa ctcagtttag atactgggac
      601 actggagaaa aagtcaggag cttgtgaaga tcatagtatg gctcaagctg gtgaagtcgt
      661 gctgaagatg aaagtggaag ggatgacctg ccattcatgt actagcacta ttgaaggaaa
      721 aattgggaaa ctgcaaggtg ttcagcgaat taaagtctcc ctggacaatc aagaagctac
      781 tattgtttat caacctcatc ttatctcagt agaggaaatg aaaaagcaga ttgaagctat
      841 gggctttcca gcatttgtca aaaagcagcc caagtacctc aaattgggag ctattgatgt
      901 agaacgtcta aagaacacac cagttaaatc ctcagaaggg tcacagcaaa ggagtccatc
      961 atataccaat gattcaacag ccactttcat cattgatggc atgcattgta aatcatgtgt
     1021 gtcaaatatt gaaagtactt tatctgcact ccaatatgta agcagcatag tagtttcttt
     1081 agagaatagg tctgccattg tgaagtataa tgcaagctca gtcactccag aatccctgag
     1141 aaaagcaata gtggctgtat caccggggct atatagagtt agtatcacaa gtgaagttga
     1201 gagtacctca aactctccct ccagctcatc tcttcagaag attcctttga atgtagttag
     1261 ccagcctctg acacaagaaa ctgtgataaa cattgatggc atgacttgta attcctgtgt
     1321 gcagtctatt gagggtgtca tatcaaaaaa gccaggtgta aaatccatac gagtctccct
     1381 tgcaaatagc aatgggactg ttgagtatga tcctctacta acctctccag aaacgttgag
     1441 aggagcaata gaagacatgg gatttgatgc taccttgtca gacacgaatg agccgttggt
     1501 agtaatagct cagccttcat cggaaatgcc gcttctgact tcaactaatg aattttatac
     1561 taaagggatg acaccagttc aagacaagga ggaaggaaag aattcatcta agtgttacat
     1621 acaggtcact ggcatgactt gcgcttcctg tgtagcaaac attgaacgga atttaaggcg
     1681 ggaagaagga atatattcta tacttgtggc cctgatggct ggcaaggcag aagtaaggta
     1741 taatcctgct gttatacaac ccccaatgat agcagagttc atccgagaac ttggatttgg
     1801 agccactgtg atagaaaatg ctgatgaagg agatggtgtt ttggaacttg ttgtgagggg
     1861 aatgacgtgt gcctcctgcg tacataaaat agagtctagt ctcacaaaac acagagggat
     1921 cctatactgc tccgtggccc tggcaaccaa caaagcacat attaaatatg acccagaaat
     1981 tattggtcct agagatatta tccatacaat tgaaagctta ggttttgaag cttctttggt
     2041 caagaaggat cggtcagcaa gtcacttaga tcataaacga gaaataagac aatggagacg
     2101 gtcttttctt gtgagtctgt ttttctgtat tcctgtaatg gggctgatga catatatgat
     2161 ggttatggac caccactttg caactcttca ccataatcaa aacatgagta aagaagaaat
     2221 gatcaacctt cattcttcta tgttcctgga gcgccagatt cttccaggat tgtctgttat
     2281 gaatttgctg tcctttttat tgtgtgtacc tgtacagttt ttcggaggct ggtacttcta
     2341 cattcaggct tataaagcac tgaagcataa gacagcaaat atggacgtac tgattgtgct
     2401 ggcaaccacc attgcatttg cctactcttt gattattctt ctagttgcaa tgtatgagag
     2461 agccaaagtg aaccctatta ctttctttga cacaccccct atgctgtttg tgtttattgc
     2521 actaggccga tggctggaac atatagcaaa gggcaaaaca tcagaggctc ttgcaaagtt
     2581 aatttcacta caagctacag aagcaactat tgtaactctt gattctgata atatcctcct
     2641 cagtgaagaa caagtggatg tggaacttgt acaacgtgga gatatcatta aagtagttcc
     2701 aggaggcaaa tttccagtgg atggtcgtgt tattgaagga cattctatgg tagatgagtc
     2761 cctcatcaca ggggaggcaa tgcctgtggc taagaaacct ggcagcacag tgattgctgg
     2821 ttccattaac cagaacgggt cactgcttat ctgcgcaaca catgttggag cagacacaac
     2881 cctttctcaa attgtcaaac ttgtggaaga ggcacaaaca tcaaaggctc ctatccagca
     2941 gtttgcagac aaactcagtg gctattttgt tccttttatt gtttttgttt ccattgccac
     3001 cctcttggta tggattgtaa ttggatttct gaattttgaa attgtggaaa cctactttcc
     3061 tggctacaat agaagtatct cccgaacaga aacgataata cgatttgctt tccaagcctc
     3121 tatcacagtt ctgtgtattg catgtccctg ttcactggga ctggccactc caactgctgt
     3181 gatggtgggt acaggagtag gtgctcaaaa tggcatacta ataaaaggtg gagagccatt
     3241 ggagatggct cataaggtaa aggtagtggt atttgataag actggaacca ttactcacgg
     3301 aaccccagtg gtgaatcaag taaaggttct aactgaaagt aacagaatat cacaccataa
     3361 aatcttggcc attgtgggaa ctgctgaaag taacagtgaa caccctctag gaacagccat
     3421 aaccaaatat tgcaaacagg agctggacac tgaaaccttg ggtacctgca tagatttcca
     3481 ggttgtgcca ggctgtggta ttagctgtaa agtcaccaat attgaaggct tgctacataa
     3541 gaataactgg aatatagagg acaataatat taaaaatgca tccctggttc aaattgatgc
     3601 cagtaatgaa cagtcatcaa cttcgtcttc catgattatt gatgcccaga tctcaaatgc
     3661 tcttaatgct cagcagcata aagtcctcat tggtaaccgg gagtggatga ttagaaatgg
     3721 tcttgtcatt aataacgatg taaatgattt catgactgaa catgagagaa aaggtcggac
     3781 tgctgtatta gtagcagttg atgatgagct gtgtggcttg atagccattg cagacacagt
     3841 gaagcctgaa gcagaactgg ctatccatat tctgaaatct atgggcttag aagtagttct
     3901 gatgactgga gacaacagta aaacagctag atctattgct tctcaggttg gcattactaa
     3961 ggtgtttgct gaagttctac cttctcacaa ggttgctaaa gtgaagcaac ttcaagagga
     4021 ggggaaacgg gtagcaatgg tgggagatgg aatcaatgac tccccagctc tggcaatggc
     4081 taatgtggga attgctattg gcacaggcac agatgtagcc attgaagcag ctgatgtggt
     4141 tttgataagg aatgatcttc tggatgtagt ggcaagtatt gacttatcaa gaaagacagt
     4201 caagaggatt cggataaatt ttgtctttgc tctaatttat aatctggttg gaattcccat
     4261 agctgctgga gtttttatgc ccattggttt ggttttgcag ccctggatgg gatctgcagc
     4321 aatggctgct tcatctgttt ctgtagtact ttcttctctc ttccttaaac tttacaggaa
     4381 accaacttac gagagttatg aactgcctgc ccggagccag ataggacaga agagtccttc
     4441 agaaatcagc gttcatgttg gaatagatga tacctcaagg aattctccta aactgggttt
     4501 gctggaccgg attgttaatt atagcagagc ctctataaac tcactactgt ctgataaacg
     4561 ctccctaaac agtgttgtta ccagtgaacc tgacaagcac tcactcctgg tgggagactt
     4621 cagggaagat gatgacactg cattataaaa ggccatggag agtgctgcca gtttaacttg
     4681 tcatgcactg acacagcatt catgatgtta ccttcacttt tcaaaatatt gtagaaggat
     4741 ttttctcatg ctcttatatt agggattcta tttgagttgc gtttatctgt tggcaaaaat
     4801 atctttttca aggcatcagc tctgaaccta gctttattta aactgaattt ccagtatatt
     4861 tttgtttttt cactaacaac agataaggta gagcagtgag gtttacaaca agccctacaa
     4921 ttagagattg ctgaactgct gctaaagtga tttttttttt atttgaccaa aaaaaaaaag
     4981 gcccaagaag aagaaaatga aaaatttgaa gatttgagag catgaagata ttcatgcttt
     5041 tgaactcaaa atattgaaga tactctcaag cctgtatccc tgcccactgg ggagcaatga
     5101 ctttcaaagc actgtgtata aaacatctag ttttagaagg gaaacagttg aaactgttta
     5161 aaaatagatg tgccttattt attgcaggct ttctttcccc cattctccct gcatccttgt
     5221 ccttgcaggt gcttttttag atgctccaat atgtcttctt ttgttatttt ctttcgagct
     5281 aaccagttta gggtggtttt tcattgatta aaaataactg acaactgttc taatattttg
     5341 ctccttttta aattttgtag ctcaaaagac cttaaaggtc tgtagggttc cctgcctccc
     5401 atctttccac tgttgtaaaa agtatatcaa attattcctt caagtttcct agctctgtgc
     5461 tcagtttcag ttcactcctg ccaagttgga ctctaagtta ttcttcatgt agtctgctga
     5521 tctcagtctg gaaacttaac attatgagcc ttttctgctc aaaaaatttt caaagattaa
     5581 aactattata catatacagg tcatataaaa ttacctggat tcactaaatt tgtttgttgt
     5641 tgttgttgtt gttgttgttg ttgttgagac agagtcttgt tttgcagccc aggctggagt
     5701 gcagtggcac catcttggct cactgcaacc tctgcctacc ggattcaagg aattctccct
     5761 gcctcagcct cctgagtagc taggattaca ggtgcctgcc accacacccg gctaattttc
     5821 atatttttca gtagagacgg ggtttcgcca tgttggctag cctggtctta aactcctaac
     5881 ctcaggtgat ccacccgcct tggcctccca aagtgctggg attacaggtg tgagcctcca
     5941 tgcccagcct aaatttgtat tttttgaatt gagtataaca ctttgctagt atatataatt
     6001 taatagattt tatttatctt tttagtgttt cagataacct ctcaaaaaga ctttaaaata
     6061 atgctattac acaaaagctg catttaccaa aaaatacaag taaaatcata atacagaaac
     6121 taaaatttcc ctaggttatg acgcttttta gctaaatata tactcttctc tagtttaaaa
     6181 catttgaact tgcctagtta gtgtggttgg caaatttagg agcttgttcc cattgccaaa
     6241 tggatttaga aattcccttg tgagtgcctg gtagctaata cactggtcag agatctggta
     6301 cttgtaagac tatttaaatt tctttgttag ttgcaagatg gatttcatat gcagaatatg
     6361 taaatgaaga ggactcataa gtaaattcct aacattttgt tcccattacc agaagcaaag
     6421 ctgctgctaa cccaacatct ggcacatagg atttgtactc ggtaaatgtt agttcttttc
     6481 tccccttgag gtcagtaata aatacaaaaa aaaaatcatt tttctagagc agagtcttaa
     6541 aatcaggtgg gggtagggga tggacttctt cctttcctac cccttttctc ttttatcctt
     6601 tcatatatac acatgcaaag tttacaacct tattccatgc tgtctttcag atttagaaaa
     6661 gatctaattt ctgtctcagc tgtcttaaag agagatccaa gcttttgatg aaggtgctat
     6721 taatctagaa aggcaaaccc atttcactga aatatcaatg ggtttgcata tctaggccct
     6781 ttttttagac caatgcctat gccatcctcc atgctttcag tttgagtttt attatttatt
     6841 attttaattc cagtggccca tcttataata caacttgttt cttctagaag acagagctga
     6901 tagggtaaat gttgaaaaaa gaagcatgcc tccttctccc tcccacccac ctcaagcagt
     6961 tgaacacagc cagttattct tccattatta tgtgtacctt ggagtcatcc tcttggtctt
     7021 gtattcatat tgtgggacag tgggaatagc agcttgtagt attgaaataa tcaaagagat
     7081 aatttcagct cttacaacaa gaacagaaaa catgctaatt agaaaaagtc ctgctttaag
     7141 taatatgtag ccacatttga atcctctacc acaagtcttt ttggcaatct tgaactttca
     7201 ttagcttcaa agagaagctg tctttacagg agaaagaggt gattatggag ggaatcaaaa
     7261 ttactgcttt cagctagtag ctagctttta gtcaggagtt agtaatgaga aattttataa
     7321 atgtgtattt ctgtgtattc acatacatat atatatacac acatatatat gtacatacac
     7381 atacatacat attaccatac tgaagggaaa tggatttata tttgaatttg atatttgaat
     7441 atttgaagtt ctctatttat atttcattta tcactcttct gtattcactc agcaaccatg
     7501 cccttagtct gaagataaca aggatacttt aatatccagt gccggttcag actcacctat
     7561 gtggcacctt aaacttaaat atccaaagag cccttttgaa tttcaaagat taaaacacag
     7621 ctagagtagt agtattgtag tctcaagatg tatggtgtgt catttgtgaa aatagaaacg
     7681 ttatttttcc tagtttagta tcaacatttt agaatgtcaa atttgatgcc ttgtgaacaa
     7741 gtaattttat attgtgcttt aattttttaa aaagtattct ttattcatat gtatagaatg
     7801 cttaaaatag cactgtagac aagatgtttc caaaacttta agtgcgcata tcttttctgt
     7861 atacaggctt aaaatcaaaa atgtatgtta agagaatttt ttctattact tatggatcat
     7921 gctttaaaat gatttttctt gatatttatt ttactccatt ttgttttttt ctctgggtga
     7981 ggcatctggt tactggttat tttaaaaaga ataaagacat tcctggaatc actccttttg
     8041 ggtttttgtt tgttttgttt cttttctaca tttttaagta ttattttaca aaatagaaaa
     8101 aatatagatt catgccaaat tattacctat ttttacacta actttctgca gtccctccat
     8161 ctggtatgag taaccagata gagcacaagc atgagttctt gttcttcagt taaaagagct
     8221 tctttcacag tgttgataac aaatgccttt tgtagccaaa accaggcgtc tcaaccttac
     8281 gtttttagtt aaagaaatgt ttagctaaac gctgttgaac attgattgtt tggtaccgaa
     8341 aacagcagtg gacgatgttg tgcaatatcc atctactgta gttaagatat tcagtagttt
     8401 gtttttcata agcatgtaat tgatcatatt tctgccaagg atgtgccttc aactttataa
     8461 ttatagtgtt gtaaaata
//