From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Drosophila melanogaster hedgehog protein (hh) mRNA, complete cds.
Date: 6 Nov 92 18:27:34 GMT
Distribution: bionet
Checksum: 02536 5

LOCUS       DROHHB       2046 bp ss-mRNA            INV       02-NOV-1992
DEFINITION  Drosophila melanogaster hedgehog protein (hh) mRNA, complete cds.
ACCESSION   L05404
KEYWORDS    hedgehog (hh) gene.
SOURCE      Drosophila melanogaster (strain Canton S) (library: cDNA library of
            Kauvar) 3-12 hr embryo cDNA to mRNA.
  ORGANISM  Drosophila melanogaster
            Eukaryota; Animalia; Metazoa; Arthropoda; Uniramia; Insecta;
            Pterygota; Neoptera; Holometabola; Diptera; Brachycera;
            Cyclorrhapha; Schizophora; Drosophiloidea; Drosophilidae.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Tashiro,S., Michiue,T., Higashijima,S.-i., Zenno,S., Ishimaru,S.,
            Takahashi,F., Orihara,M., Kojima,T. and Saigo,K.
  TITLE     Structure and expression of hedgehog, a Drosophila segment polarity
            gene required for cell-cell communication
  JOURNAL   Gene (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..60
                     /gene="hh"
     exon            1..540
                     /number=1
                     /gene="hh"
     exon            541..802
                     /number=2
                     /gene="hh"
     exon            803..2046
                     /number=3
                     /gene="hh"
     3'UTR           1477..2046
                     /gene="hh"
     CDS             61..1476
                     /function="segment polarity; cell-cell communication"
                     /gene="hh"
                     /product="hedgehog protein"
                     /codon_start=1
                     /translation="MDNHSSVPWASAASVTCLSLGCQMPQFQFQFQLQIRSELHLRKP
                     ARRTQTMRHIAHTQRCLSRLTSLVALLLIVLPMVFSPAHSCGPGRGLGRHRARNLYPL
                     VLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADGLMSK
                     RCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKY
                     GMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGVRKPLG
                     ELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGGAVLTVTPAHLVSVW
                     QPESQKLTFVFAHRIEEKNQVLVRDVETGELRPQRVVKLGSVRSKGVVAPLTREGTIV
                     VNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVSSAQQQNGIH
                     WYANALYKVKDYVLPQSWRHD"
BASE COUNT      518 a    535 c    539 g    454 t
ORIGIN      
        1 attaaaggag atacaaaatc caatcaagag aaacagcaaa caacgagtct tagataaatc
       61 atggataacc acagctcagt gccttgggcc agtgccgcca gtgtcacctg tctctccctg
      121 ggatgccaaa tgccacagtt ccagttccag ttccagctcc aaatccgcag cgagctccat
      181 ctccgcaagc ccgcaagaag aacgcaaacg atgcgccaca ttgcgcatac gcagcgttgc
      241 ctcagcaggc tgacctctct ggtggccctg ctgctgatcg tcttgccgat ggtctttagc
      301 ccggctcaca gctgcggtcc tggccgagga ttgggtcgtc atagggcgcg caacctgtat
      361 ccgctggtcc tcaagcagac aattcccaat ctatccgagt acacgaacag cgcctccgga
      421 cctctggagg gtgtgatccg tcgggattcg cccaaattca aggacctcgt gcccaactac
      481 aacagggaca tccttttccg tgacgaggaa ggcaccggag cggatggctt gatgagcaag
      541 cgctgcaagg agaagctaaa cgtgctggcc tactcggtga tgaacgaatg gcccggcatc
      601 cggctgctgg tcaccgagag ctgggacgag gactaccatc acggccagga gtcgctccac
      661 tacgagggcc gagcggtgac cattgccacc tccgatcgcg accagtccaa atacggcatg
      721 ctcgctcgcc tggccgtcga ggctggattc gattgggtct cctacgtcag caggcgccac
      781 atctactgct ccgtcaagtc agattcgtcg atcagttccc acgtgcacgg ctgcttcacg
      841 ccggagagca cagcgctgct ggagagtgga gtccggaagc cgctcggcga gctctctatc
      901 ggagatcgtg ttttgagcat gaccgccaac ggacaggccg tctacagcga agtgatcctc
      961 ttcatggacc gcaacctcga gcagatgcaa aactttgtgc agctgcacac ggacggtgga
     1021 gcagtgctca cggtgacgcc ggctcacctg gttagcgttt ggcagccgga gagccagaag
     1081 ctcacgtttg tgtttgcgca tcgcatcgag gagaagaacc aggtgctcgt acgggatgtg
     1141 gagacgggcg agctgaggcc ccagcgagtg gtcaagttgg gcagtgtgcg cagtaagggc
     1201 gtggtcgcgc cgctgacccg cgagggcacc attgtggtca actcggtggc cgccagttgc
     1261 tatgcggtga tcaacagtca gtcgctggcc cactggggac tggctcccat gcgcctgctg
     1321 tccacgctgg aggcgtggct gcccgccaag gagcagttgc acagttcgcc gaaggtggtg
     1381 agctcggcgc agcagcagaa tggcatccat tggtatgcca atgcgctcta caaggtcaag
     1441 gactacgtgc tgccgcagag ctggcgccac gattgagatg aaatcctgga agagcgatcc
     1501 tgatcccaac gatcctgtat tgtattatat cctgtagtta tgtatatgcc taatgattga
     1561 tgtatttcaa tgttgaatat cgttaataat cgatcgatac tatttattta ccaccacaaa
     1621 tcaaaaaccc acacacaaaa acacccccac ccaagcgata aagcaaagag caaatgagta
     1681 tgaaatcaaa acgatgcgaa acgaaatgaa aacactgtta aatgtccttg acttatttgt
     1741 tttgcaaaca ttttagctgt aagtaggcaa tcctcggcgc agatcctaaa tcatcctgag
     1801 aaaatcaatc ggcaaactcc cggagaacac agacgctgtt actgtatatt atcatggaat
     1861 tgaattgcat aatttattga ggtgcggcgg cgagttcaag ccctttgata taatatatat
     1921 cctactttgt atatagaaga agcattatag tgactgaata tcttattgta attgtgtata
     1981 taatacttaa tagttaactg cgtatttata cttaatattt aatgaaatat aaagaaattg
     2041 tttgat
//