From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mus musculus P-selectin protein mRNA, complete cds.
Date: 27 Aug 92 10:00:37 GMT
Distribution: bionet
Checksum: 45110     7

LOCUS       MUSPSELEC    3075 bp ss-mRNA            ROD       27-AUG-1992
DEFINITION  Mus musculus P-selectin protein mRNA, complete cds.
ACCESSION   M87861
KEYWORDS    GMP-140; P-selectin; PADGEM; antigen CD62;
            granule membrane protein 140;
            platelet activation dependent granular external membrane protein.
SOURCE      Mus musculus (strain ICR) (library: lambda gt10) endothelial cDNA
            to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Weller,A., Isenmann,S. and Vestweber,D.
  TITLE     Cloning of the mouse endothelial selectins: Expression of both E-
            and P-selectin is inducible by tumor necrosis factor alpha
  JOURNAL   J. Biol. Chem. 267, 15176-15183 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             10..2316
                     /product="P-selectin"
                     /codon_start=1
                     /translation="MAGCPKGSWTPRLRSVILGGAQLIWFSALISELVNQKEVAAWTY
                     NYSTKAYSWNNSRVFCRRHFTDLVAIQNKNEIAHLNDVIPFFNSYYWIGIRKINNKWT
                     WVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYT
                     ASCQDMSCSNQGECIETIGSYTCSCYPGFYGPECEYVKECGKVNIPQHVLMNCSHPLG
                     EFSFNSQCTFSCAEGYELDGPGELQCLASGIWTNNPPKCDAVQCQSLEAPPHGTMACM
                     HPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQWSEPLPTCEAIACEPPEIPIHGS
                     MDCVPSTGTFGYNSSCTFLCAEGFVLKGNDAIQCADSGQWTAPAPFCEALQCPEFPVP
                     SKAQVNCSDPFGTLTYQSVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVSCAP
                     MLSPENGSMTCVQPLGNSTYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGTPPTCEAI
                     KCPGIFAPEQGNLDCSHVHGEFGVGSICHFSCNEDFELLGSENVECTVSGRWSAPPPT
                     CKGITSLPAPAVRCPALTTPGQGTMSCQHHLGSFGPNTTCYFGCKTGFTLRGANSLRC
                     RASGQWTAVTPMCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCTFQCPEGQSLNGSV
                     RATCREDGHWSDAMPTCQAGTLTIQEALTYLGGAVASTTGLAVGGTLLALLRKRLRKK
                     DDGKCPLNPHSHLGTYGVFTNAAYDPTP"
     sig_peptide     10..117
                     /codon_start=1
     mat_peptide     133..2313
                     /note="lectin, EGF, and transmembrane domains"
                     /product="P-selectin"
                     /codon_start=1
     repeat_region   607..2136
                     /rpt_type=tandem
                     /rpt_unit=607..792
BASE COUNT      784 a    854 c    747 g    690 t
ORIGIN
        1 agagaggaca tggctggctg cccaaaaggt tcctggacgc caagactccg gagtgtgatc
       61 ctgggagggg ctcaactcat ctggttcagt gctttgatct ctgagcttgt aaatcagaag
      121 gaagtggctg cgtggaccta taactacagc acaaaggcat actcatggaa taactcacgg
      181 gtgttctgta ggaggcactt cacagactta gtggccatcc agaataagaa tgaaatcgct
      241 cacctcaatg acgtcatccc attcttcaac tcttactact ggattggtat ccgaaagatc
      301 aacaataagt ggacctgggt gggaacaaat aagacactca cggaggaggc tgagaactgg
      361 gccgacaacg agcccaacaa caagaagaac aatcaggact gtgtggagat ctacatcaag
      421 agtaactcgg cccctggcaa gtggaatgat gaaccctgtt ttaaacgaaa gcgggccctg
      481 tgctacacag cctcctgcca ggacatgtcc tgcagcaacc aaggggagtg catcgagacc
      541 attgggagct atacctgctc ctgctaccca ggcttctatg ggccagagtg tgaatacgtc
      601 aaggagtgtg gaaaagtcaa catccctcaa catgttctca tgaactgcag ccatcccctg
      661 ggggagttct ccttcaactc acagtgcacc ttcagctgtg ctgagggcta cgagctggac
      721 ggacccggcg agctgcaatg tttggcttct gggatctgga caaataaccc cccgaagtgt
      781 gacgctgtgc aatgtcagag cctggaagcc cctccccatg gaaccatggc ctgtatgcac
      841 ccaattgctg cctttgccta cgactccagc tgtaaatttg agtgccagcc tggatataga
      901 gcgaggggct ccaacacact ccactgcact ggctctggtc agtggagtga accactgcca
      961 acctgtgaag ctattgcgtg tgaacctccg gagatcccca tccatgggag catggactgc
     1021 gtcccatcta caggaacctt tgggtacaac agcagctgca cttttctctg tgcagagggg
     1081 ttcgtgctga agggaaatga tgccattcag tgtgctgact ccgggcagtg gacagcccca
     1141 gccccattct gtgaagcgtt gcaatgtcca gagtttccgg ttcccagtaa agcccaggtg
     1201 aactgctcgg atcccttcgg taccttgacg taccagtcag tctgcagctt ttcctgtgat
     1261 gaaggctcgc tcttggtggg agcaagtgtg ataagatgcc tggctactgg acactggaat
     1321 ggggctcctc ccgaatgtca agctgtgtcc tgtgccccta tgctcagtcc tgagaatgga
     1381 tccatgacct gcgttcagcc tcttgggaat tccacctaca aatccacatg ccagttcatg
     1441 tgcgatgaag gattttatct atctggaccg gaaagactgg attgttctcc atctggacac
     1501 tggacaggca cccctcccac gtgtgaagcc atcaagtgtc caggaatctt cgccccagag
     1561 caaggcaacc tggattgttc tcatgtccac ggagagtttg gtgttggctc tatctgtcac
     1621 ttctcctgca atgaggactt tgagctactg ggatctgaaa atgtggaatg cacagtgtct
     1681 ggaagatggt cagcacctcc gccaacctgc aaaggcataa catcacttcc tgccccagca
     1741 gtccgatgcc ctgccctcac gactcctgga cagggcacaa tgtcctgcca acaccacctg
     1801 ggaagctttg gtccgaacac cacttgttac tttgggtgca aaaccggatt tacactcagg
     1861 ggagccaact cgctccgctg cagggcttca ggacaatgga cagcagtgac ccccatgtgc
     1921 agagcggtca aatgctccga attgcacatg gacacagcag tagcaatgaa ctgttccaat
     1981 ccctggggaa actttagcta tggatcaacc tgcaccttcc agtgcccaga ggggcagtca
     2041 ctgaacggct ctgtgagagc aacctgccga gaggacggtc actggtcaga tgccatgcca
     2101 acctgccaag cagggacact gacaatccag gaagctctga cgtacttggg tggtgcagtg
     2161 gcttctacaa caggcctggc agtgggcggg acactcctgg ctctgctaag aaagcgtctc
     2221 agaaagaaag atgatggaaa atgccccttg aaccctcaca gccacctagg aacatacgga
     2281 gtcttcacta acgctgcata tgacccaacc ccttaagaaa cccggtctgc caatgtctca
     2341 ttcgatttct caggattcca catgcaagtg tcaagtttcc tgtcacactt gactgtaact
     2401 ccatggcatt tgggcatttg ctgaggttct ctgtagttta aaacaaaaaa caaaacaaaa
     2461 caaaaaaaag gacaggaacc tagaaaaaga actatgcact ttcccacctc tccacccacc
     2521 ccttcctgct ccgcccctca ccttcctcca gctccgcccc ttcctgctcc gcccctcacc
     2581 ttcctccagc tccgcccctt cctgctccgc ccctcacctt cctccagctc agccacagac
     2641 ccaggagcaa atgtttctgc tctggtctgt ggcttgttgt tactttgctg ttgctgaaaa
     2701 cgggagagtc caaggccctg gagcatcttc ctcaccaggt gaccaggctc tggaaaaccg
     2761 aaggtctttc tcttgggatt gcagagtagc aatgttggtg ggcaggcaga cctctagttt
     2821 aaggggatgc ctgctttaag atctcctggg tcttccatgt ttcatatcaa tgaggttgtt
     2881 tacacctctg ctgctgagac tttcacagaa acctccagat ggtactaggg gacacagaag
     2941 atctggaaca gagccaagac gtcacatctg actgcagact ttccctccac caaagcaccc
     3001 aaagatcatt gtttggatgt ataaataact caacttcccc aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaaaaa aaaaa
//