From: skhare@aiims.ernet.in
Newsgroups: bionet.jobs
Subject: (none)
Date: 1 Sep 92 15:24:15 GMT
Distribution: bionet




     Position looking for : Post Doctoral Research Fellow in Immunology

	
                        CURRICULUM VITAE
     
                         SANJAY D. KHARE
     
	
     Date of birth       : May 28,1964
     Sex                 : Male
     Nationality         : Indian
     
     Present address     : 8/56, Gents' Hostel
                           All-India Institute of Medical Sciences
                           New Delhi 110 029, India.

	e-mail           : skhare@aiims.ernet.in
     
     Permanent address   : 486/2, Shastri Nagar
                           Kanpur 208 005, India.
     
     EDUCATION
     
     1982 B.Sc. (Biology), Christ Church College, Kanpur University,                        
     Kanpur
     
     1985  M.Sc. (Life Sciences), KN Kaul Institute of Life  Sciences, 
     Kanpur University, Kanpur
     
     1992 (expected) Ph.D. (Immunology), All-India Institute of  Medi-
     cal Sciences, New Delhi, India.
     Title of the Ph.D. thesis : Role of food antigen(s) in the  immu-
     nopathogenesis of rheumatoid arthritis.
     
     Award and Fellowships 
     
     1.  Junior Research Fellowship of Indian council of  Medical  Re-
     search,  1986.
     2.  Award of Krishnan Research Fellowship from the Department  of 
     Atomic Energy, 1988.
     
     RESEARCH INTEREST
     
     MHC and Autoimmunity; Immunological tolerance;   Immunopathogene-
     sis  of  autoimmune diseases; B cell function and  lymphokine  in 
     autoimmune diseases, Immunology of HIV
     
     PUBLICATIONS
     
     a) on systemic rheumatic diseases
     
     Malaviya AN, Singh RR, Sindhwani R, Singh YN, Khare SD, Kumar  A, 
     Malaviya  R, Negi PC and Ramachandran K. Treatment of  lupus  ne-
     phritis with cyclophosphamide in Indian patients. In  Proceedings 
     of  the IInd international conference on SLE  (Singapore  26-30th 
     Nov 1989). Ed ML Boey, Professional Postgraduate Services, Inter-
     national Publishers (Tokyo), pp 203-5.






     Malaviya  AN, Ansari MA, Singh YN, Kapoor SK, Singh RR, Kumar  A, 
     Rajdan  RK,  Khare SD and Sharma VP.   Epidemiology  of  systemic 
     lupus erythematosus in India. In Proceedings of the IInd interna-
     tional  conference  on SLE (Singapore 26-30th Nov  1989).  Ed  ML 
     Boey, Professional Postgraduate Services, International Publish 
     ers (Tokyo), pp 25-28.
     
     Malaviya AN, Kumar A, Singh YN, Singh RR, Dash SC, Khare SD, Wali 
     JP,  Sharma SK, Hamda R and Saluja S. Wegner's Granulomatosus  in 
     India : Not so rare. Br. J. Rheumatol., 1990; 29: 499-500.
     
     Kumar A, Malaviya AN, Singh YN, Singh RR, Dash SC, Khare SD, Adya 
     CM,  Wali  JP, Sharma SK, Handa R and Saluja S.  Experience  with 
     Wegner's Granulomatosus. Bull IRA, 1991; 5: 63-66. 
     
     Malaviya AN, Malaviya R, Singh RR, Negi PC, Kumar A, De A,  Khare 
     SD and Sindhwani R. Effect of high dose intravenous pulse   dexa-
     methasone on lymphocyte phenotypes. Indian J. Med. Res.[B], 1991; 
     94: 99-101.
     
     Malaviya  AN, Singh RR, Sindhwani R, Singh YN, Ahuja  RK,  Bhuyan 
     UN,  Khare SD, Kumar A, Malaviya R, Negi PC and  Ramachandran  K. 
     Intermittent  intravenous  pulse  cyclophosphamide  treatment  in 
     systemic  lupus erythematosus. Indian J. Med. Res.[B], 1992;  96: 
     101-108.
     
     
     b) on HIV and AIDS
     
     Malaviya  AN,  Singh RR, Khare SD, Malaviya R, Seth P,  Kiran  U, 
     Kumar  A, Kumar A, Chawla NPS, Bhargava NC, Kollali VV, Murthy  L 
     and  Koicha M. AIDS screening in north India : Clinical  spectrum 
     of HIV infection. J. Assoc. Physicians India, 1987; 35:405-410.
     
     Seth  P,  Malaviya AN, Kiran U, Singh RR, Khare SD,  Malaviya  R, 
     Kumar  A and Bhargava NC. Lack of evidence of endemicity  of  HIV 
     infection in northern India. Indian J. Med. Res., 1988; 87:  108-
     112.
     
     Malaviya AN, Seth P, Singh RR, Tripathy SP, Chaudhry K, Singh YN, 
     Khare  SD, Kiran U, Pandhi RK, Bhargava NC and Nanu A.  AIDS  and 
     HIV-1 screening in northern India. Natl. Med. J. India, 1989;  2: 
     22-25.
     
     Singh  YN, Malaviya AN, Tripathy SP, Chaudhry K, Bhargava NC  and 
     Khare SD. HIV serosurveillane among prostitutes and patients with 
     sexually  transmitted diseases clinic in Delhi, India. J  Aquired 
     Imm Def Synd 1990; 3: 287-89.
     
     Singh YN, Malaviya AN, Tripathy SP, Chaudhry K, Khare SD, Nanu  A 
     and Bhasin R.  HIV infection in blood donors of Delhi, India.   J 
     Acquired Imm Def Synd 1990; 3: 186-88. 






     Singh  YN,  Bhargava M, Malaviya AN, Tripathy SP,  Kakkar  A  and 
     Khare SD. HIV infection in Asian Indian patients with haemophilia 
     &  those  who had multiple transfusion. Indian J.  Med.  Res.[A], 
     1991; 93: 12-14. 
     
     c) infectious diseases
     
     Sharma SK, Pande JN, Singh YN, Verma K, Kathait SS, Khare SD  and 
     Malaviya AN.  Pulmonary function and immunologic abnormalities in 
     Miliary tuberculosis. Am. Rev. Respir. Dis., 1992; [in press].
     
     
     Paper presented in conferences
     
     Khare SD, Singh N, Beri D, Singh YN, Sailindri K and Malaviya AN. 
     Food intolerance in the immunopathogenesis of rheumatoid  arthri-
     tis.  International Food Allergy Symposium organized by  American 
     Association  of  Immunologists  and  Allergologists,  July  1990; 
     Toronto, Canada.
     
     Khare  SD,  Beri D, Singh N, Singh YN, Nath I  and  Malaviya  AN. 
     Effect of diet elimination on immune system in rheumatoid arthri-
     tis.  XVII  Annual  Conference  of  Indian  Immunology   Society, 
     December  1990; Sanjay Gandhi Postgraduate Institute  of  Medical 
     Sciences, Lucknow, India.
     
     Khare  SD, Singh N, Singh YN, Pande I, Kumar A and  Malaviya  AN.  
     Antibodies to dietary antigens in rheumatoid arthritis.  National 
     Annual  Conference  of Indian  Rheumatism  Association,  December 
     1991; King Georges' Medical College, Lucknow, India.
     
     Khare SD, Singh N, Kumar A, Mehra NK and Malaviya AN.   Decreased 
     lymphoproliferative  response to dietary antigens  in  rheumatoid 
     arthritis.  Winter Advanced Course of Immunology  and  Infectious 
     Diseases organized by JIFF, March 1992; Hongkong.
     






     SUMMARY OF THE RESEARCH
     
     My  Ph.D.  research  has  been done  in  the  laboratory  of  Dr. 
     A.N.Malaviya, Professor of Medicine (Clinical Immunology)  at the 
     All-India  Institute of Medical Sciences.  The main focus  of  my 
     graduate  research has been the immunopathogenesis of  rheumatoid 
     arthritis  (RA).  As part of the laboratory's  continuing  effort 
     on  etiopathogenesis of rheumatoid arthritis,  a work  on  immune 
     response to dietary antigen(s) was carried out.  
     
     My  project  involves   studies on  immune  response  to  dietary 
     antigens in RA, involvement of genetic factors in food related RA 
     and  a study of oral tolerance in mouse. Clinical trial  of  diet 
     elimination  showed that most of the RA patients had  intolerance 
     with  chick  pea, milk and wheat. Host's responsiveness  to  diet 
     elimination was found to be associated with HLA DR1 haplotype.  A 
     decreased   lymphoproliferative response to chick pea,  milk  and 
     wheat  gliadin  was seen in RA as compared to  healthy  controls.  
     These  patients had elevated levels of anti milk and  anti  chick 
     pea  antibodies.  After diet elimination immune response to  milk 
     in  RA  was  comparable to healthy individuals.  Anti  chick  pea 
     antibodies  seem  to  have   reactivity  with  bovine  and  human 
     collagen  II (seen by inhibition ELISA).  These observations  led 
     us to study the role of intragastric administration of chick  pea 
     in developing oral tolerance in collagen-induced arthritis (CIA).  
     A  mouse model (DBA/1) of CIA was developed.   Adoptive  transfer 
     of  spleenocytes from chick pea fed mouse to unfed  inbred  mouse 
     showed  suppression in arthritis,  decreased  lymphoproliferative 
     response to collagen II and low levels of anti collagen II  anti-
     bodies.  
     
     I  presented  this work in above mentioned  conferences  and  now 
     three  manuscripts  are under preperation  from my  PhD  work  as 
     first  author of the same. In addition to my PhD work I  am  also 
     involved  in  some  other  immunology  related  projects  of   my 
     department.   I  am  having co-authorship  in  thirteen  research 
     publications and now I hope to first author three research papers 
     from my PhD work.
     
     In addition I have learnt a wide variety of techniques  including 
     chromatography,  electrophorasis, western blotting,  ELISA,  cell 
     culture, T cell assays, HLA typing and flow cytometry.
     
     My  long term goal is to  pursue an independent carrier in  Immu-
     nology.  I am especially interested in questions of immunological 
     tolerance,  MHC-peptide   and TcR interaction,  epitope  mapping, 
     mechanism  of autoantibody production, lymphocyte phenotypes  and 
     lymphokines.