From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Schistosoma mansoni epidermal growth factor receptor (SER, class 1
Date: 21 Aug 92 10:12:49 GMT
Distribution: bionet
Checksum: 52746    12

LOCUS       SCMEGFRA     6051 bp ss-mRNA            INV       21-AUG-1992
DEFINITION  Schistosoma mansoni epidermal growth factor receptor (SER, class 1
            product) mRNA, complete cds.
ACCESSION   M86396
KEYWORDS    EGF receptor; epidermal growth factor receptor;
            receptor tyrosine kinase.
SOURCE      Schistosoma mansoni (strain Puerto Rican) male adult cDNA to mRNA.
  ORGANISM  Schistosoma mansoni
            Eukaryota; Animalia; Eumetazoa; Platyhelminthes; Trematoda;
            Digenea; Strigeidida; Strigeata; Schistosomatoidea;
            Schistosomatidae.
REFERENCE   1  (bases 1 to 6051)
  AUTHORS   Shoemaker,C.B., Ramachandran,H., Landa,A., dos Reis,M.G. and
            Stein,L.
  TITLE     Alternative splicing of the Schistosoma mansoni gene encoding a
            homologue of epidermal growth factor receptor
  JOURNAL   Mol. Biochem. Parasitol. 53, 17-32 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             49..5202
                     /note="class 1 product"
                     /product="epidermal growth factor receptor"
                     /gene="SER"
                     /codon_start=1
                     /translation="MNFLLPTLVIIFALNCWSLKFSISEYPWIKACRVWERDCSKPNP
                     KHIQLTYIKFLYGGCTHIIGNLVICGLEKLENGSDPDLSFLEKIEDVSGYVYIGQNSV
                     KTISLPSLKVIRGEPGYRIMNTSAALVISRNSLEILDLRSLTAIQRNDIVALNNQFLC
                     NFGFTIDWEQIFEDNRKQMFIPDRKEKTVSHAGCDIALRKYTDDRTKHSCHGSCPVVN
                     GRGYCWGPKPEMCQKMLKCANNPDNYCLGGRATTQPCLEECLGGCETRPGNCRACKHA
                     MNDGKCVSQCPPPLIVSREESRTVANPEFKYNFHDICVKNCPAPFLKSDSYCVIECDL
                     NTQIPVNGTCKDCPKSGCPEHCKEETIFVNGSLNILQSSSLRKFKSCVYYTGGLYISK
                     ESFQKSSLFPDPIQNVNELYNLLHLKSIVGYIYFDLREAPEELKNLTFLENLESVVLE
                     VKSQSPGAVITIMNGENIESFGFKSLTNIGGYVYLKNMPKLCYISALTKMLPVRMIDV
                     QDEELCAKRGHVCHSECLPELGCWGADANMCAHCCGLKAGEYCVSRCTDHPGFYELPT
                     PFNHSILGKTTNNPVCRTLPLTKSDMAEMDEQAIIASVIPSKTCAICHPECAQTCYGP
                     NANQCVGECKHYQHGDTCLPECPRNTYIDPQTRHCLPCNESCSHILTTGQNQLCSGPG
                     NFLGLGGCETCWTVIQDKITNKYQCLPDDCPPKHYTESYQTQDFINKEKIIVSSHSQV
                     KKGELGGMIRVCKPCHPFCDLCTANGTHASICHSCTHWWFKSECVEICPPAETYSLAG
                     SDKELDNQEMFENDLITLSNNTQFSSNQLKEFTFLSNVSTTTNASIDDNQQEYKTSSL
                     AAPVFLIKLKRTQRRCLLCHEQCIQGCSGPGPEDCVKCRNYQIILDEETNKFVCNSSC
                     PEDRNHIFHGMCLTAEQNARLSGQTARELRNRILIGVSVSVFIIIALVTIILVVCLKR
                     KAEAEKIREQLRSAYTNLLEPDMKTQSVSREPNMGRLEMINQDDLFCDFNSAPLGTGS
                     FGAVYKGVWKVPKHALLRYNWHRGAQLDVAIKVILNDSPECSVTANPSSPFEAGNSSY
                     SEEEAKRASVRANIEELLQEAKIMASVMHRHCLPLIGICLSSERHCLVSIFVELGALD
                     RYVKQHADELNSLTLLSWAEQIADGMSYLEMRGIIHRDLAARNVLVQTREHVQITDFG
                     LAKMLERRDEDSVIVKAGRVPIRWLAIETLQYGIYSHKTDVWSYGVTLWEIFTFGKRP
                     YEDVDTVDIKDHVIKGGRLTQPDICTLDVYMVLVKCWMEDYESRPTFIELMRTFNTFC
                     KTPGRYLYIEGDQYAINYFHNTNSGSGNFSSESHELQPMLSVRGIPDGGTTPHRNNSL
                     HRHHTMLTEPSMTRPYSSGKLLRALSDQPSERSDLFSVGQTGEHTETQLLLPIRSNNS
                     NSGNHSTWQSRQHGVGTGASSNTSDTNFSGLGRIWKRSNFHDKVNTDNTSLLKQRKAP
                     LASREDSWLNDIPRQSDHSESRSSVALSDPATASTTAKTSEWSGISPYNQSRNHSNFG
                     GKNLEEMNTKFSPHTHGNSSNSFGKNTVSDYLLDPPPPPPVPRGLPDEYLQPKTKNPT
                     NTSHAYSSALSKSMNYTELGPPMVTNPSTTRDEYLSPNMQPPEEYLSPISGGFSVTNP
                     EYLMETYGHPQQYPEPNTLKQSTNPASDSNSPLKFQDKTNQNESSSLEL"
     sig_peptide     49..105
                     /gene="SER"
                     /codon_start=1
     mat_peptide     106..5199
                     /note="class 1 product"
                     /product="epidermal growth factor receptor"
                     /gene="SER"
                     /codon_start=1
     polyA_site      6016
                     /gene="SER"
                     /evidence=EXPERIMENTAL
BASE COUNT     1941 a   1150 c   1124 g   1836 t
ORIGIN
        1 tttggcacgt tttcgaaagt tgatggggtt cgacagaaca attcttaaat gaatttttta
       61 ctacctactc tggttattat tttcgctctt aattgctggt ccttaaaatt ttccatttct
      121 gagtacccat ggattaaagc ctgtcgtgtt tgggagagag actgctcgaa gcctaatcca
      181 aaacatatac agctcactta catcaagttt ttatacggag gttgtactca cataatcggg
      241 aatttggtta tatgcggtct agagaaactt gaaaatggat ccgatcctga tctttctttt
      301 cttgaaaaga ttgaagatgt gtccggttat gtgtacattg gtcaaaacag tgttaaaacg
      361 atatcattac cgtctttgaa agttattcgc ggtgaaccgg gatatcgtat catgaatact
      421 agtgctgcac ttgttattag tcgaaacagt cttgaaatcc tagatttacg aagtttgaca
      481 gccattcaac gcaacgatat tgtagcatta aataatcagt ttttgtgcaa ctttggtttc
      541 acgattgatt gggaacagat ttttgaagac aaccgtaaac aaatgtttat accggatcga
      601 aaagaaaaaa cagtttctca cgccggttgt gatattgctc tacgaaaata cactgatgat
      661 cgtaccaaac attcctgtca tggttcctgt cctgtggtaa atggacgagg ttattgctgg
      721 ggtccaaagc ctgagatgtg tcaaaaaatg ctaaaatgcg ctaacaatcc tgataactat
      781 tgtcttggtg gtagagcgac tacacaacca tgtctggaag aatgcttggg tggatgcgaa
      841 actcgtcctg gcaattgtag agcatgcaaa catgctatga atgatggcaa atgtgtatca
      901 caatgtcctc caccattgat agttagtcga gaagagagta gaactgttgc aaatccagaa
      961 ttcaaatata acttccatga catttgcgtt aaaaattgcc cagcaccatt tctgaaatca
     1021 gacagttact gcgtcattga atgtgacttg aatacccaaa ttcctgttaa tggaacgtgc
     1081 aaggactgtc caaagtctgg atgtcctgaa cattgtaaag aagaaacaat ctttgtaaat
     1141 ggaagtttga atatcttaca atcaagttca cttcggaaat ttaaatcatg tgtttattat
     1201 actggtggtt tgtatataag taaagaatcc tttcaaaaaa gttcactgtt tccagatcca
     1261 atacaaaatg tcaatgaact ctacaattta ttgcacctga aatcaattgt tgggtacatc
     1321 tattttgatt tacgtgaagc tcccgaagaa ttgaaaaatt taacatttct agaaaatcta
     1381 gaatcagttg ttttagaagt gaaaagtcaa tctccaggag cagtgattac aataatgaat
     1441 ggagaaaata tcgagtcatt tggtttcaaa tcacttacta atattggagg ttatgtatat
     1501 ttgaagaata tgccaaaatt atgttatatt agtgcgttaa caaaaatgct acctgtgcgt
     1561 atgatagatg tacaagatga agaactttgt gctaaacgtg gtcatgtttg ccacagtgaa
     1621 tgtttaccag agcttggttg ttggggtgct gatgctaaca tgtgtgctca ttgttgtggt
     1681 ttaaaggctg gtgaatattg cgtgtctcgg tgtacagatc atcctggttt ttatgaactt
     1741 ccaacacctt tcaatcattc aattctagga aagaccacta ataatcctgt ttgtcgaact
     1801 ttacccttaa ctaaaagtga catggcagaa atggatgagc aagcaatcat tgcatccgta
     1861 atcccttcaa aaacatgtgc catctgtcat ccagaatgtg ctcagacatg ttatggtcct
     1921 aatgcaaatc agtgtgttgg agaatgtaag cactaccagc atggtgacac ctgtttacct
     1981 gaatgtccac gaaatacata catagatccg caaactcgtc attgtttacc ttgtaatgag
     2041 tcgtgcagtc acatattgac gactggacaa aatcaattat gtagtggccc agggaacttc
     2101 cttggcttag gtggttgtga aacatgttgg acagtaatac aagataagat aacaaacaaa
     2161 taccaatgtc tacccgatga ttgtcctcct aaacactaca cagaatctta tcaaacacaa
     2221 gatttcataa acaaagaaaa aatcattgta tcctctcata gtcaagttaa aaaaggtgaa
     2281 cttggtggta tgatccgtgt gtgtaaacca tgtcatccat tttgtgactt gtgtacagca
     2341 aacggaacac atgcatctat atgtcatagt tgtactcatt ggtggtttaa atcggaatgt
     2401 gtagagattt gtccacccgc ggaaacatat tcactagcgg gatctgataa agagttggac
     2461 aatcaagaaa tgttcgaaaa tgatttaatt actctcagta acaataccca gttctcatca
     2521 aatcaattaa aagaattcac ttttctatct aacgtttcta caactaccaa tgctagcatt
     2581 gatgacaatc aacaagaata caaaacgtcc tcactagcag ctccagtatt tctaatcaaa
     2641 ctaaaacgta cgcagcgtcg ttgtttgctc tgtcatgaac agtgtattca aggttgttct
     2701 ggacctggtc cagaagattg tgttaaatgt agaaactatc aaattatctt ggatgaagaa
     2761 acaaataaat tcgtttgtaa ttcttcctgt ccagaggatc gcaatcatat ttttcatggc
     2821 atgtgtttaa cagctgaaca aaacgcacgt ttatctggtc aaacagctcg agaattgcgt
     2881 aatagaattc ttattggtgt ttctgtttct gtatttatca ttattgcact cgttacaata
     2941 atactagtgg tatgtttgaa acgaaaagct gaagcagaaa aaatacgtga acaactacgc
     3001 tcagcatata ctaacttgtt agaacctgat atgaaaactc aatccgtaag tcgtgaacca
     3061 aatatggggc ggctggaaat gatcaatcag gatgacttgt tttgtgattt caactcagct
     3121 cctctaggaa caggatcatt tggagctgta tacaaaggtg tatggaaagt acctaaacat
     3181 gctctactcc gatataattg gcatagaggt gctcagctag atgttgcaat taaagttatc
     3241 ttaaatgatt cacctgaatg ttccgtaacc gcaaacccat cgtctccatt tgaggctggt
     3301 aattcgtctt attcagaaga agaagcaaag cgggcgtccg tacgtgctaa tattgaggaa
     3361 cttcttcagg aagccaagat tatggcatct gttatgcatc gtcattgtct tccactaatt
     3421 ggaatatgtc tatccagtga acgtcattgc ttagtttcaa tattcgttga attaggggct
     3481 ctggatcgct atgtaaaaca acatgcagat gagttaaata gtctcacact tttatcttgg
     3541 gctgaacaaa ttgctgatgg aatgagctac ctggaaatgc gtggaattat ccatcgagat
     3601 ttggctgccc gaaacgttct cgttcagaca cgtgaacatg tacagattac tgattttggt
     3661 ttagctaaaa tgttagaacg ccgtgatgaa gacagtgtca tcgtaaaagc tggccgtgtg
     3721 ccaatacgtt ggttagctat agaaacacta caatatggga tttattctca caaaacagac
     3781 gtttggagtt acggtgtgac gttatgggaa atatttacat ttggcaaacg accatatgaa
     3841 gatgttgata ctgtagatat taaggatcat gtaatcaaag gtggacgttt gactcaacct
     3901 gacatatgca ccttggacgt ttatatggta ttggtgaaat gttggatgga agattacgag
     3961 tctcgtccta catttattga acttatgcgt acatttaata ctttttgcaa aactcctggc
     4021 cgttatctat acattgaagg tgatcaatat gcaatcaatt actttcacaa cacaaattca
     4081 ggttcaggga acttctcctc tgagtctcat gaacttcaac caatgttgtc cgtacgcggg
     4141 atccctgatg gaggcacaac gccacacagg aataatagtt tacaccgtca tcataccatg
     4201 ttaacagaac caagtatgac tagaccttat tcttcaggaa agctacttcg agctttatct
     4261 gaccagccca gtgaaagatc tgatctattt tcggttggtc agactggtga acatacagaa
     4321 acacaacttt tgctacccat tcgatcaaat aatagtaact ctggaaacca ttctacctgg
     4381 caatcacgac agcatggagt tgggactgga gcttcttcaa atacctctga tacaaatttt
     4441 tcggggctag gaagaatatg gaagagatca aactttcatg acaaggtcaa cacagataat
     4501 acaagtttgt taaaacaacg caaggctcct ttggcttctc gagaggactc ctggttaaac
     4561 gatattccta gacagtcaga tcattctgaa tcaagaagct ctgttgcttt atctgaccca
     4621 gctactgctt ctaccactgc taaaacttcc gaatggtcag gaatatcacc ttataatcaa
     4681 tcacgcaatc attctaattt tggtggtaag aatttagagg aaatgaacac taaattcagt
     4741 ccacacacac atggcaattc atcaaacagt tttggaaaaa atactgtttc agactatcta
     4801 cttgatccac ctccaccacc acctgtacca cgtggcttac cagatgaata tttgcaaccg
     4861 aaaactaaaa atcctacaaa tacatcacac gcatacagta gtgcgctgtc aaaatcgatg
     4921 aattatactg aattgggccc accaatggtt accaatcctt ctactactag agatgaatac
     4981 ttaagtccga atatgcagcc gccagaagaa tacttatctc cgatatccgg tggatttagc
     5041 gtaaccaatc cagagtactt aatggaaaca tacggtcatc cacagcaata cccagagcca
     5101 aatacattaa aacaaagcac aaatcctgct agcgactcaa attccccgct gaaatttcag
     5161 gataaaacaa accaaaatga gtcatcctcg ctggaattat agatacaaca ttcgctgcca
     5221 acccttccgc tttttcccca ccggaatagt gaaaaacaac agactattca ttttaaaatg
     5281 atacaacagt gacactgatg tttgttactt ccttctattt ttattttatt atttgtcata
     5341 cctataaaaa ccaaataaag aatgatcaat gtgtaaacac tccggaagtc aatgcataag
     5401 catgttcaca gtggattttg tatggttcat tcatcgtgat gatagatatt tacatttttc
     5461 caacggttaa agaaaaagtc aaggatgaat gaagaacaat aatgctgtaa gaaaaagatg
     5521 catctcaata ttcatttgtc ctccttctcc ttccgtaatt ttaatttcag tttattgatt
     5581 acatacaaac agatactact tcttactagc atttttacca aagtattact tcataccatt
     5641 gcttcctgtg tatttcgggt aattttcttt ccaaaaacca ttcaatttat cctgaattat
     5701 aattgcttgc ttgtctatgg actcactaaa actgtttgtt ggattgtcgt ctatgcatca
     5761 ttcattgttc ccaagatagg cagaaaccag gaccatgagg atatatattg atataccgct
     5821 tgttcgtaat gagcactgtt tgcaaacact gccttataaa ccaaacatgt ttcagatgca
     5881 tttattgtca gattcggcga cattttaatg taaatagaca tcattctttt cgttgtcatt
     5941 tgcatgctgg ttctttttta aaacaaataa tatgaatact ctgtctattt tacattgaat
     6001 ccattataaa accaagtatt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//