From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human (K562) c-myc proto-oncogene, mRNA.
Date: 5 Nov 92 23:10:59 GMT
Distribution: bionet
Checksum: 08044 6

LOCUS       HUMMYCM      2121 bp ss-mRNA            PRI       15-MAR-1985
DEFINITION  Human (K562) c-myc proto-oncogene, mRNA.
ACCESSION   V00568
KEYWORDS    c-myc oncogene; chromosomal translocation; constant region;
            gene activation; heavy chain mu switch region; myc oncogene;
            proto-oncogene; transforming gene.
SOURCE      Human K562 leukemic cells, cDNA to mRNA, several clones.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Watt,R., Stanton,L.W., Marcu,K.B., Gallo,R.C., Croce,C.M. and
            Rovera,G.
  TITLE     Nucleotide sequence of cloned cDNA of human c-myc oncogene
  JOURNAL   Nature 303, 725-728 (1983)
  STANDARD  full automatic
COMMENT     The myc gene is the cellular homologue of the transforming gene
            carried by the avian myelocytomatosis virus MC29. Unlike the ras
            proto-oncogenes which obtain transforming potential through
            mutations within their coding exons (namely mutations within codon
            12), the myc gene identified as the cause of Burkitt lymphomas
            acquires its transforming potential through defects of either
            transcriptional or translational control. Thus it is not an altered
            gene product that induces tumors, but a normal product that is
            present either in the wrong quantity or at the wrong time in the
            life cycle of the cell.
               See other human c-myc entries.
               Corresponds to EMBL (release 3.0) entry <hsmyc1>, dated
            05-JUL-1983.
FEATURES             Location/Qualifiers
     mRNA            <1..>2121
                     /note="c-myc mRNA"
     CDS             559..1878
                     /product="c-myc protein"
                     /codon_start=1
                     /translation="MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPA
                     PSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGTFSTADQLEMV
                     TELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSG
                     SPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSP
                     SSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKR
                     SESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLR
                     QISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPK
                     VVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA"
BASE COUNT      502 a    649 c    565 g    405 t
ORIGIN      10 bp upstream of HaeIII site.
        1 ctgctcgcgg ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa
       61 gggcagggct tctcagaggc ttggcgggaa aaaagaacgg agggagggat cgcgctgagt
      121 ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga
      181 gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg
      241 cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg
      301 cttgatcccc caggccagcg gtccgcaacc cttgccgcat ccacgaaact ttgcccatag
      361 cagcgggcgg gcactttgca ctggaactta caacacccga gcaaggacgc gactctcccg
      421 acgcggggag gctattctgc ccatttgggg acacttcccc gccgctgcca ggacccgctt
      481 ctctgaaagg ctctccttgc agctgcttag acgctggatt tttttcgggt agtggaaaac
      541 cagcagcctc ccgcgacgat gcccctcaac gttagcttca ccaacaggaa ctatgacctc
      601 gactacgact cggtgcagcc gtatttctac tgcgacgagg aggagaactt ctaccagcag
      661 cagcagcaga gcgagctgca gcccccggcg cccagcgagg atatctggaa gaaattcgag
      721 ctgctgccca ccccgcccct gtcccctagc cgccgctccg ggctctgctc gccctcctac
      781 gttgcggtca cacccttctc ccttcgggga gacaacgacg gcggtggcgg gacgttctcc
      841 acggccgacc agctggagat ggtgaccgag ctgctgggag gagacatggt gaaccagagt
      901 ttcatctgcg acccggacga cgagaccttc atcaaaaaca tcatcatcca ggactgtatg
      961 tggagcggct tctcggccgc cgccaagctc gtctcagaga agctggcctc ctaccaggct
     1021 gcgcgcaaag acagcggcag cccgaacccc gcccgcggcc acagcgtctg ctccacctcc
     1081 agcttgtacc tgcaggatct gagcgccgcc gcctcagagt gcatcgaccc ctcggtggtc
     1141 ttcccctacc ctctcaacga cagcagctcg cccaagtcct gcgcctcgca agactccagc
     1201 gccttctctc cgtcctcgga ttctctgctc tcctcgacgg agtcctcccc gcagggcagc
     1261 cccgagcccc tggtgctcca tgaggagaca ccgcccacca ccagcagcga ctctgaggag
     1321 gaacaagaag atgaggaaga aatcgatgtt gtttctgtgg aaaagaggca ggctcctggc
     1381 aaaaggtcag agtctggatc accttctgct ggaggccaca gcaaacctcc tcacagcccc
     1441 ctggtcctca agaggtgcca cgtctccaca catcagcaca actacgcagc gcctccctcc
     1501 actcggaagg actatcctgc tgccaagagg gtcaagttgg acagtgtcag agtcctgaga
     1561 cagatcagca acaaccgaaa atgcaccagc cccaggtcct cggacaccga ggagaatgtc
     1621 aagaggcgaa cacacaacgt cttggagcgc cagaggagga acgagctaaa acggagcttt
     1681 tttgccctgc gtgaccagat cccggagttg gaaaacaatg aaaaggcccc caaggtagtt
     1741 atccttaaaa aagccacagc atacatcctg tccgtccaag cagaggagca aaagctcatt
     1801 tctgaagagg acttgttgcg gaaacgacga gaacagttga aacacaaact tgaacagcta
     1861 cggaactctt gtgcgtaagg aaaagtaagg aaaacgattc cttctaacag aaatgtcctg
     1921 agcaatcacc tatgaacttg tttcaaatgc atgatcaaat gcaacctcac aaccttggct
     1981 gagtcttgag actgaaagat ttagccataa tgtaaactgc ctcaaattgg actttgggca
     2041 taaaagaact tttttatgct taccatcttt tttttttctt taacagattt gtatttaaga
     2101 attgttttta aaaaatttta a
//