From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Murine cytomegalovirus immediate-early protein 2 (ie2) gene;
Date: 28 Dec 92 21:28:36 GMT
Distribution: bionet
Checksum: 11850 23

LOCUS       HS5IE123X   10206 bp ds-DNA             VRL       01-DEC-1992
DEFINITION  Murine cytomegalovirus immediate-early protein 2 (ie2) gene;
            immediate-early protein 3 (ie3) gene; immediate-early protein 1
            (ie1) gene, complete cds's.
ACCESSION   L06816
KEYWORDS    immediate-early protein 1; immediate-early protein 2;
            immediate-early protein 3.
SOURCE      Murine cytomegalovirus (strain Smith) (library: ATCC VR-194) embryo
            DNA.
  ORGANISM  Murine cytomegalovirus
            Viridae; ds-DNA enveloped viruses; Herpesviridae;
            Betaherpesvirinae.
REFERENCE   1  (sites)
  AUTHORS   Keil,G.M., Ebeling-Keil,A. and Koszinowski,U.H.
  TITLE     Sequence and structural organization of murine cytomegalovirus
            immediate-early gene 1
  JOURNAL   J. Virol. 61, 1901-1908 (1987)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Messerle,M., Keil,G.M. and Koszinowski,U.H.
  TITLE     Structure and expression of murine cytomegalovirus immediate-early
            gene 2
  JOURNAL   J. Virol. 65, 1638-1643 (1991)
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   Messerle,M., Buehler,B., Keil,G.M. and Koszinowski,U.H.
  TITLE     Structural organization, expression, and functional
            characterization of the murine cytomegalovirus immediate-early gene
            3
  JOURNAL   J. Virol. 66, 27-36 (1992)
  STANDARD  full automatic
COMMENT     *cell type = fibroblast
               Reference [1] reports bases 4682 to 8045; reference [2] reports
            bases 204 to 3353; reference [3] reports bases 7991 to 9792.
FEATURES             Location/Qualifiers
     mRNA            complement(join(3230..3307,1860..1983,225..1494))
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
     mRNA            join(4682..4981,5807..5917,6015..6205,8061..9763)
                     /gene="ie3"
                     /evidence="EXPERIMENTAL"
     mRNA            join(4682..4981,5807..5917,6328..8030)
                     /gene="ie1"
                     /evidence="EXPERIMENTAL"
     exon            complement(225..1494)
                     /number=3
                     /standard_name="immediate-early gene 2"
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     prim_transcript complement(225..3307)
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
     polyA_signal    complement(242..247)
                     /gene="ie2"
                     /label=pA
                     /citation=[2]
                     /note="putative"
     intron          complement(1495..1859)
                     /number=2
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     exon            complement(1860..1983)
                     /number=2
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     intron          complement(1984..3229)
                     /number=1
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     exon            complement(3230..3307)
                     /number=1
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     TATA_signal     complement(3331..3335)
                     /gene="ie2"
                     /note="putative"
     enhancer        3600..4350
                     /evidence="EXPERIMENTAL"
     TATA_signal     4654..4658
                     /citation=[1]
                     /note="putative"
     exon            4682..4981
                     /number=1
                     /function="untranslated leader of ie1 and ie3 mRNA"
                     /gene="ie1/ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     prim_transcript 4682..9763
                     /function="transactivator"
                     /standard_name="immediate-early gene 3"
                     /gene="ie3"
                     /evidence="EXPERIMENTAL"
                     /label=ie3
                     /citation=[3]
     prim_transcript 4682..8030
                     /function="regulatory protein"
                     /standard_name="immediate-early gene 1"
                     /gene="ie1"
                     /evidence="EXPERIMENTAL"
                     /label=ie1
                     /citation=[1]
     intron          4982..5806
                     /number=1
                     /gene="ie1/ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
                     /citation=[1]
     exon            5807..5917
                     /number=2
                     /gene="ie1/ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
                     /citation=[1]
     intron          5918..6014
                     /number=2
                     /gene="ie1/ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
                     /citation=[1]
     exon            6015..6205
                     /number=3
                     /gene="ie1/ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
                     /citation=[1]
     intron          6206..8060
                     /number=4
                     /gene="ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
                     /note="alternative splicing"
     intron          6206..6327
                     /number=3
                     /gene="ie1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     exon            6328..8030
                     /number=4
                     /gene="ie1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     polyA_signal    8002..8007
                     /gene="ie3"
                     /citation=[1]
                     /note="putative"
     exon            8061..9763
                     /number=5
                     /gene="ie3"
                     /evidence="EXPERIMENTAL"
                     /citation=[3]
     polyA_signal    9736..9741
                     /citation=[3]
                     /note="putative"
     CDS             join(5811..5917,6015..6205,6328..7817)
                     /function="regulatory protein"
                     /gene="ie1"
                     /label=pp89
                     /citation=[3]
                     /product="immediate-early protein 1"
                     /codon_start=1
                     /translation="MEPAAPSCNMIMIADQASVNAHGRHLDENRVYPSDKVPAHVANK
                     ILESGTETVRCDLTLEDMLGDYEYDDPTEEEKILMDRIADHVGNDNSDMAIKHAAVRS
                     VLLSCKIAHLMIKQNYQSAINSATNILCQLANDIFERIERQRKMIYGCFRSEFDNVQL
                     GRLMYDMYPHFMPTNLGPSEKRVWMSYVGEAIVAATNIDHALDERAAWAKTDCSLPGE
                     FKSEMCVLVGAIRRLHDPPCYTKPFLDARSQLAVWQQMKAIESESVSTHVVVVEALKL
                     RENLAKAVQETIAYERHQYHRVCQMMCNNMKDHLETTCMLARGRTLATLADLRSTRYN
                     LALFLLSEMHIFDSFTMPRIRGAMKQARCMSYVERTISLAKFRELADRVHNRSAPSPQ
                     GVIEEQQQAGEEEQQQQQEIEYDPEMPPLEREEEQEDEQVEEEPPADEEEGGAVGGVT
                     QEEPAGEATEEAEEDESQPGPSDNQVVPESSETPTPAEDEETQSADEGESQELEGSQQ
                     LILSRPAAPLTDSETDSDSEDDDEVTRIPVGFSLMTSPVLQPTTRSATAAASSGTAPR
                     PALKRQYAMVHTRSKSSENQQQPKKKSKK"
     CDS             join(5811..5917,6015..6205,8061..9598)
                     /function="transactivator"
                     /gene="ie3"
                     /evidence="EXPERIMENTAL"
                     /label=IE3
                     /citation=[3]
                     /citation=[1]
                     /product="immediate-early protein 3"
                     /codon_start=1
                     /translation="MEPAAPSCNMIMIADQASVNAHGRHLDENRVYPSDKVPAHVANK
                     ILESGTETVRCDLTLEDMLGDYEYDDPTEEEKILMDRIADHVGNDNSDMAIKHAAGPE
                     MNIDIVTAAASMSGITTASHSALPIRRPNTPDFRRHSEKKAKKHKNKQRQRLDDVVAK
                     LHKPSESEADEDFIFQQPQEEEYQEEQEPQVISSSPQHFDERSPSRSSSDHGGHSGGN
                     SRDGQFYLSSGSEDEDDEDDERVDSGYRGSSRSEDSSRYRPHGGSHSSRSSIKSSGSG
                     SSRHHHKRKAVPERHHPFTPPSAKRYAAAAPSSRYECPVRVDSSDSDDAPTMVQRGTL
                     KIKSFRPPSSGSNSNKHSSSSGGSTSSSHKKQQQQQAPSKKPVMSSGSDKIRDMVDRT
                     AGGYVAPNAHKKCREDKSRKYPARALEYKNLPFRPQSPQYLLGKAIQFCKEETVHDKF
                     IMLFYTRSQDVRKAVDETRARMGMRPNLSISCPFMTEHTKPINHSRETIDRTSAACTA
                     GTQAVWDMEERRGQKCVPRTSDYRSMIIQAANPPDFLGAVKTCLHLSQVFPKQVCMRL
                     CSITGGLNPLPIYEETVSSYVNAQFEADDISHHEDESGEYESDCE"
     CDS             complement(317..1492)
                     /function="unknown"
                     /standard_name="immediate-early gene 2"
                     /gene="ie2"
                     /evidence="EXPERIMENTAL"
                     /label=IE2
                     /citation=[2]
                     /product="Immediate-early protein 2"
                     /codon_start=1
                     /translation="MERVRGASSSDSVATLHGDHNYHCMATFKLDCTSARTRGVVSIL
                     EHRDPATVDDIFMQRVCHDINDVLRPVECLTSFPEYRRTLRVAVEAATELHGVSALSG
                     QLTKFLEDHDGAMLPLAWPPNRYLRLTSGRKLGYLDVAEKLRKEYPMCNGPLEVLGVI
                     LGPGQSLYSDQHPVLLMGLTGTIFLHARGRPVWSPDYDPERDADRLFLAAESLQSFGR
                     EGLCRCDNVYTEDGGAPYATPEDPVLKNIVFTPHLGGKALHQQICKIKGHTWYLNGCP
                     GMLKDRVFVATPDIPPFVRHVNLELFGHRFLPIGRVTRSPEDPECEMFIMVDAGGAIY
                     GHMLDSGKVRRLADNFDQFMRMGTRRVISISRWLREVVSTPSTRRPRLGPRTTGSFS"
BASE COUNT     2539 a   2693 c   2688 g   2286 t
ORIGIN      
        1 ggatcccccc gagagattgt tagacttcaa ccagtacgta gcaactttat tatcctcggc
       61 ctccccccct accggcgcag caaaacttta ttaaccccca cggcggtaga gtgcgagttc
      121 aaggacgcat ccgagacact caggacacca tactactgca tgcccctcac atcgggggaa
      181 ccccctccgg ggcgagtctt ttacaggcta caacgactgt ccgatgaata aaacctcttt
      241 atttattgat taaaaaccat gacatacctc gtgtcctctc actgaatctt cttcctgacg
      301 gtcaccaggt ctctggtcaa gagaaagaac ccgtggtcct tggtcccaaa cgaggtctcc
      361 tcgtactcgg tgttgagact acctccctta accacctgga aattgaaata accctccggg
      421 tgcccatccg catgaactgg tcaaagttat cagctagcct cctcaccttc ccgctatcta
      481 acatgtgccc gtagatggcc cccccggcgt ccaccatgat aaacatctca cactcgggat
      541 cctcggggga acgggtcacc ctaccgatgg gtagaaacct atgtccaaag agttccaggt
      601 tcacgtggcg gacgaagggg gggatgtccg gcgtggcgac gaacaccctg tccttcagca
      661 tgccggggca accgttcagg taccaggtgt gtcccttgat cttacagatc tgctggtgga
      721 gcgccttccc gccgagatgg ggcgtgaaca cgatgttctt gagcacgggg tcctcgggag
      781 tagcgtacgg agcgccgccg tcctcggtgt agacgttgtc gcacctgcag agtccttccc
      841 taccgaagga ctgcagggac tcggcggcca ggaagagtcg atcggcgtcc cgctccggat
      901 cgtagtcggg actccagacg ggcctgcctc tggcgtggag gaagatggtc ccggtgaggc
      961 ccatcaagag gacggggtgc tggtcgctgt agagggactg tccgggtccg aggatcacgc
     1021 cgagaacctc gaggggaccg ttgcacatgg ggtattcctt gcgcagcttc tccgccacgt
     1081 cgagataacc cagctttctg cccgacgtca ggcgaaggta cctgttcggg ggccaggcca
     1141 ggggcagcat cgctccatcg tggtcctcca agaacttggt cagctggccg gacagagcgg
     1201 agacgccgtg gagttcggtg gcggcctcca cggccaccct cagggttctt ctgtattcgg
     1261 ggaagctcgt gagacattcg accggccgca gcacgtcgtt gatgtcgtga cagacccgct
     1321 gcataaagat atcgtccacg gtcgcggggt ccctgtgctc caggatactt acaacccccc
     1381 gggtccgagc cgaagtgcaa tccagcttga aggtcgccat gcagtggtag ttgtgatcgc
     1441 cgtggagggt cgccaccgag tctgaggagg aagctccccg aacacgctcc atatctacag
     1501 acaaacagaa ccgtgagcag tcgcgtccct cacgcccccg gacccgagag actctcacta
     1561 cagctgctac cccgacctcc gtgctgcaat cagaaagaag aatggatcga gcgagcgagc
     1621 gaacgaccgg gcgggcgggc gagagcaaga gtcccttcac caagaaatga ccggtcacca
     1681 gcatccgtgc agagaacacc gccgtcttac ctgctccgtg ctcggacgct ctgctctgag
     1741 ctttatctca cctgtgcagc ctaggtcacc ttgcaaatct cccacaatgc tattctgtca
     1801 ggacacaagg actattgtat aagatccgca gggacacgtc agccagccac tgtactcact
     1861 agtaacaaca ggtcagcagc acctgtcccg gtgtcctcat ctccccgagg aagtcctcta
     1921 gcggcgtcag tctgaagaac aaaggtatct cagtagcgag tccggagcag gggcgtagct
     1981 gacctatgga gaacaagaga gatcagtctc gaaaggtgcg ctcatgtact cgagtcattc
     2041 aaagatcagg aagactgcgg tcgttcgcga tgtccgcacg tcaatctacc tggatcagga
     2101 agaaggaagc ccgggccagg gtcgtccgag gcctgggccg cacaccgtcc acaatgaaca
     2161 agaaggtgac cttccctccc agacaatgca cctcagtgag gaacggtgtt tgtggaagcg
     2221 tgtgtccttc caaagaggac atctgctatc aattgagctc tgtcagtggg cgggggtctg
     2281 gcagagatga gcaggaaaac gttttagagc tgcttttcaa caggagtgtc tcttggcagt
     2341 ctcggacact gggaggatct cggacccctt cccctgggtc attataagat ccagtatttt
     2401 tcccaactgt tcagtgtcag gacacgcagc tctggagctc tgcagaccgt ctcccggccg
     2461 ctcccgagcc acccgggcgc ccgctcccga tcctctctcg ttcccggcgt cccgccgccc
     2521 gctcgactcg atccctcggc cgaacccagc aacggagact acgctggccc tcccgggatg
     2581 atccgaacaa cgcgtttcgg caggtgagcg cagctttcta gccctttttc tgctcggaat
     2641 ccgagccgag cggcgaccga gaaaacgaaa gtaaaaaccc gggcggtccg cggatttcga
     2701 tcgctcgaat aaaattatag aggggagcta aaatttttcc tgcgtcctgg ggggcatcta
     2761 tagggtctaa ggcacatacc ccgggggtgg gttgcgtttc ggaagcagga tcgagggaag
     2821 aaaaagcgat cgaaagtagc ggtcgccatc ttgtatagcc ctgacagctg ttacgggcgg
     2881 ctgtgatttt cgatctctga tataaaaata caagcagccg ctaggggtcg cccacctatc
     2941 caggcacgta ccctggggtc taaggcacag atcatggggg tcggatgctt tccagctata
     3001 gaaatgagac ccccgggagc gatcgaaaac cgcggtagcc atcttgtata gaaccgaaag
     3061 taccgctatg ggcgggcgcc aatggcgtgg tagggggctt ctaattacgt gacgcaatat
     3121 gtatgggtag ggggcgttat attaataagc cccctaccca taagacccca cccatattaa
     3181 agtaccgggc caaatccccg tcccatagcc gagcccaatg caaccttacc cggcctgggg
     3241 ggctccgttc acccgctcgt taacgtaggt agggtcgtat cgagccgcgg tccgtcctgc
     3301 tctgggctcg aatggcatgg gggacagcaa ttatatggtt aactccgccc gttttatgac
     3361 tagaaccaat agtttttaat gccaaatgca ctgaaatccc ctaatttgca aagccaaacg
     3421 ccccctatgt gagtaatacg gggacttttt acccaatttc ccacgcggaa agccccctaa
     3481 tacactcata tggcatatga atcagcacgg tcatgcactc taatggcggc ccatagggac
     3541 tttccacata gggggcgttc accatttccc agcatagggg tggtgactca atggccttta
     3601 cccaagtaca ttgggtcaat gggaggtaag ccaatgggtt tttcccatta ctggcaagca
     3661 cactgagtca aatgggactt tccactgggt tttgcccaag tacattgggt caatgggagg
     3721 tgagccaatg ggaaaaaccc attgctgcca agtacactga ctcaataggg actttccaat
     3781 gggtttttcc attgttggca agcatataag gtcaatgtgg gtgagtcaat agggactttc
     3841 cattgtattc tgcccagtac ataaggtcaa tagggggtga atcaacagga aagtcccatt
     3901 ggagccaagt acactgcgtc aatagggact ttccattggg ttttgcccag tacataaggt
     3961 caatagggga tgagtcaatg ggaaaaaccc attggagcca agtacactga ctcaataggg
     4021 actttccatt gggttttgcc cagtacataa ggtcaatagg gggtgagtca acaggaaagt
     4081 tccattggag ccaagtacat tgagtcaata gggactttcc aatgggtttt gcccagtaca
     4141 taaggtcaat gggaggtaag ccaatgggtt tttcccatta ctggcacgta tactgagtca
     4201 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg
     4261 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca
     4321 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa
     4381 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt aattaaaacg ccatgtactt
     4441 tcccaccatt gacgtcaatg ggctattgaa actaatgcaa cgtgaccttt aaacggtact
     4501 ttcccatagc tgattaatgg gaaagtaccg ttctcgagcc aatacacgtc aatgggaagt
     4561 gaaagggcag ccaaaacgta acaccgcccc ggttttcccc tggaaattcc atattggcac
     4621 gcattctatt ggctgagctg cgttctacgt gggtataaga ggcgcgacca gcgtcggtac
     4681 cgtcgcagtc ttcggtctga ccaccgtaga acgcagagct cctcgctgca gtatcctgcc
     4741 caagaaagag cgaccttccc cggctactga agcgcatcgg acccgctcgg ttctattggg
     4801 accacgccca tccgccatat tggaacagcc gccatattgg taacgccgcc atcttgattg
     4861 ggaccaccgc ccctattggg accaccgccc aattgggacc accgcccacc cagcgaccca
     4921 ggcccagagg ctacgtcacc aggacccccg gctgcccagc gccccctcga ggacacacaa
     4981 tgtaagtaga ccaaggcctt ttattggctg cggtgttaag gcaagctgcc tgtctatccc
     5041 tatctatcta ctatccacct ggctctctag ctccatactg cgtacggtgt ttgttagctt
     5101 agggtgatag caagtagaac gctggtgatg gttgctctct atcagtttag cgctggtgat
     5161 ggtggcctcc ttctccattt cttatatata tatgctggtg atggtccctc ttccatggcc
     5221 gcggtgtgct tcggtgccgg gtaccgtaac gtggtacaga aaaaggcctg acacgtacgc
     5281 gtctctccct aggatgctat gtgtctgtag caccggcgga gcttgcgagc tcgatgtcca
     5341 agatagagtc tccatgactg ctcagatcgt ctcctgtgtt cacacaccag atattacaag
     5401 cgacggccgc catgataagt ccaaaaatga gcagaataca gaatattgta ctcagaggct
     5461 gcagccatct tggtggcctg ctgtggtgct cttttcccgt ggaggactcc gtcagttcct
     5521 gcgtgttgtt gctcgtactg cgaagatctc tcttgccccg tcctgaaaac ctaggccctg
     5581 acagaaaaaa gggagagtta ggagagggca cagaggattc tgtctgtgtc aagggggctt
     5641 ccatgttgtt tctttacctg agatctcttc caccagttgt tttttatcag caactgacag
     5701 gtagtatatc aaaatgagtg cactgatgat tattagcact gtatacttta gatatcttct
     5761 ggtctctgtg gacatctgtt gatgataaaa aattatattt ttttagagag atggagcccg
     5821 ccgcacccag ttgcaacatg atcatgatcg ccgatcaggc atccgtcaac gcccacggcc
     5881 gtcacttgga tgagaaccgt gtctacccat cagacaagta agtttctgtt tccatttcct
     5941 ctcttgtgac acatttcatg actctgcatt tacataaccc ctgactcatg gtcttcccac
     6001 tcttgttctc tcagggtgcc agctcatgtc gccaacaaga tcctcgagtc tggaaccgaa
     6061 accgtccgct gtgacctgac tctggaggac atgttgggag actatgagta tgatgatccc
     6121 actgaggaag agaagatcct catggaccgc atcgctgacc acgtggggaa tgataacagc
     6181 gacatggcca tcaagcatgc tgcaggtgag tgtctcagtt attcacatca tgactcttct
     6241 aactatctta tctcctctac ctgtctctgt ctttcatatt cacccacaca gaacacttga
     6301 gttatacaaa ccactcttat attccagtga ggagcgttct gttgtcctgt aagattgcac
     6361 acctcatgat aaaacagaac tatcaatcag ccatcaactc tgctaccaac attctctgtc
     6421 agctagccaa tgatatcttc gagcgcatcg aaagacaacg caagatgata tacggctgtt
     6481 tcagatctga gtttgataat gtccagctag ggaggctcat gtatgacatg tacccacact
     6541 tcatgcccac taatctaggg ccctcagaaa agagagtctg gatgagctac gtaggtgagg
     6601 ccatagtggc agccaccaac attgaccacg cactagatga gcgtgccgca tgggccaaga
     6661 ctgattgttc attgcctggg gagtttaagt cagagatgtg tgtcctggtt ggggccatca
     6721 ggaggcttca tgatccaccc tgttacacca agcctttcct ggatgccagg tctcagctgg
     6781 cagtatggca gcagatgaag gctatagaga gtgagagcgt atccacacat gtggtagtgg
     6841 tggaagcttt gaagctcagg gagaatctgg ctaaggcagt gcaggaaacg attgcctatg
     6901 agagacacca atatcacagg gtgtgtcaga tgatgtgtaa taacatgaaa gaccatctag
     6961 agaccacctg tatgctggcc agaggcagaa ccttggctac cttagctgat ctgaggagca
     7021 ccagatacaa tctagcactt tttcttctga gtgagatgca catctttgat agcttcacca
     7081 tgcctaggat cagaggtgct atgaaacaag caaggtgtat gagttatgtg gagaggacca
     7141 tctctctggc caagttcaga gagctagctg atagagtcca taacaggagt gcaccatcac
     7201 cccagggagt gatagaagaa cagcagcagg caggggagga agaacagcaa cagcagcagg
     7261 agatagagta tgatcctgag atgccccctc tggaaagaga ggaagagcag gaggatgagc
     7321 aggtagagga ggagccccct gcagatgagg aggaaggagg agctgttggt ggtgtcactc
     7381 aagaggaacc tgctggtgaa gccactgagg aagctgaaga agatgagtcc cagcctggac
     7441 caagtgacaa ccaggtggta cctgagtctt cagagacacc aacacctgct gaggatgagg
     7501 agacccaaag tgctgatgaa ggagaatctc aggagctgga aggctcacag caactcatcc
     7561 tatccagacc tgctgcccct ctgactgaca gcgaaactga ttctgattct gaagatgatg
     7621 atgaggtgac ccgcatccca gtgggattca gtctcatgac atctcctgtc ctgcaaccta
     7681 cgaccagatc tgcaacagcg gcagcttctt ctggcactgc tcctcgccca gctctcaaga
     7741 ggcagtacgc catggtgcat accagatcca agtcttctga gaatcaacag cagcccaaga
     7801 agaagagcaa gaagtgaatc cacaagccca gctccccacc catcaccatg gacaatgttt
     7861 ttttactaac acttggacaa tgatggatac ttttttacta acacttggac aatgatgatg
     7921 atacactcct cacctgccca cttagacaca attactaaca ccacaccccc tcttttattt
     7981 ctctgtactt aatgttttct gaataaagtg atcctattgt acccacatta aagacttctt
     8041 taactcttta tggttcacag gacccgagat gaacatagat attgttacag cagcggcctc
     8101 catgtcaggt ataactactg cctcacacag cgccctgcca atcagaagac caaacacccc
     8161 agacttcaga agacactcag aaaagaaagc taagaagcat aagaacaagc agcgccagag
     8221 acttgatgat gtagttgcta agttacataa gccctctgag agtgaggcag atgaggactt
     8281 tatttttcag cagcctcagg aggaggagta tcaggaggag caggagcccc aggtgatctc
     8341 ctcctctcct caacactttg atgagaggag ccccagcagg tcttcctcag atcatggtgg
     8401 gcacagtggg ggaaacagta gagatggaca gttctatctg tctagtggtt ctgaggatga
     8461 agatgatgag gatgatgagc gggtagatag tggctacagg gggagcagta ggagtgaaga
     8521 cagcagcagg tacaggccac acggaggctc ccactcatca aggtcctcca ttaaatcatc
     8581 agggagcggg tcctctagac accaccacaa gaggaaggcg gtacctgaac gccaccatcc
     8641 tttcacacct ccctctgcga agaggtatgc cgccgctgcc cccagcagca gatatgagtg
     8701 tcctgtgcgt gtggattcct cagacagtga tgatgcccct accatggtac agagggggac
     8761 cctgaagatc aagtccttca ggccccctag ctctggttcc aactccaaca aacacagcag
     8821 cagctctggt gggtctacta gtagtagcca caagaagcaa cagcagcagc aggcccctag
     8881 caagaagcct gtgatgagta gtgggagtga taagatcaga gacatggtag acaggacagc
     8941 cggaggctac gtggccccca acgcccacaa gaagtgcagg gaagataagt ccaggaagta
     9001 cccagccagg gccttggagt acaagaacct gcccttcaga cctcagtccc cacagtatct
     9061 actgggtaag gccatccagt tctgtaagga ggagaccgtg catgacaagt tcatcatgct
     9121 gttctacacc aggagtcagg atgtgaggaa ggcagtggat gagacacgcg cccgcatggg
     9181 gatgcgcccc aacctgtcca tctcctgccc cttcatgaca gagcacacca agcccattaa
     9241 ccacagcagg gagaccatag atagaacctc agcggcctgc accgcaggta ctcaggcagt
     9301 gtgggacatg gaggagagac gaggtcagaa gtgtgtgccc aggacctcag actacaggag
     9361 catgataatt caggcagcca accctccaga cttcttggga gcggtgaaga cctgtctgca
     9421 tttgagtcag gtcttcccca agcaggtgtg catgaggctc tgcagcataa caggcgggtt
     9481 gaatcctctt cccatctatg aggagactgt cagcagttat gtgaacgccc agtttgaggc
     9541 agatgatata agccatcatg aggatgagtc tggggagtat gagtctgact gcgagtgatc
     9601 tgtactgtgg acttggtatt aaagatgaac cctgttttgt aaaatatgta gatacataac
     9661 taactaacta actgtctgtg tatatatttg attgagacct gagaccccca atcttaactc
     9721 atgtcgaacc ctattaaata aatccttttt gatatatatt gagcacttgt gtcttgtccc
     9781 tctttgtctc tgagacatca tcatgcgcgt gccagtagac accgtcctcc ttttggcggt
     9841 ggggtgttgg gcgctgttgg cgcgcggtgg cggtggtgca gagagtgccg ctcaagtgac
     9901 taacacctgg tgcctcttca ttgaagaagg aggcactact tttgtggggg aggagggaac
     9961 aggagagtat tccagacgtg atatatcagt cagcgtcggg aacaccggct gcacatccga
    10021 cgctagcaac gtgaccgtgc gagaccgccg agaacggaga cctcatcgtc aactatgaga
    10081 acggtactct gttctgtgag gccgggcctc acgttgtgaa tatcaccgtc ctacgtatgt
    10141 tattccccag tcagggagag gctctcttct gtgacaagaa cggcaccgtc agcacgctcg
    10201 ctcgag
//