From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mus musculus p-glycoprotein (mdrla) gene, exons 1 and 2.
Date: 3 Jan 93 22:07:56 GMT
Distribution: bionet
Checksum: 27753 7

LOCUS       MUSPGLYA     4313 bp ds-DNA             ROD       21-DEC-1992
DEFINITION  Mus musculus p-glycoprotein (mdrla) gene, exons 1 and 2.
ACCESSION   M96761
KEYWORDS    p-glycoprotein.
SOURCE      Mus musculus (library: T1.ZAPII) blood DNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 4313)
  AUTHORS   Cohen,D., Higman,S.M., Hsu,S.I.-H. and Horwitz,S.B.
  TITLE     The involvement of a LINE-1 element in a DNA rearrangment upstream
            of the mdr1a gene in a taxol resistant murine cell line
  JOURNAL   J. Biol. Chem. 267, 20248-20254 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     misc_feature    3481..4117
                     /note="This feature applies to a gene which lacks a coding
                     region feature. "
                     /gene="mdrla"
     repeat_region   429..1013
                     /standard_name="LINE-1"
     exon            3481..3610
                     /number=1
                     /gene="mdrla"
     intron          3611..4046
                     /number=1
                     /gene="mdrla"
     exon            4047..4117
                     /number=2
                     /gene="mdrla"
BASE COUNT     1220 a    978 c    934 g   1181 t
ORIGIN      
        1 gaattccaga gactacagaa aactccagtc ggttaagctt tgcacacaca cacacacaca
       61 cacacacaca cacacacaca tctaaaaaag aaaaacaaag ggtccttata agctaagtac
      121 atcattgaat tatcaagagt attttcatat aggcattgct aacatttttg aattttttta
      181 cacttgtatc atgttaatct ggttccaaaa attgcacagg gtccctgccc ccagttggtt
      241 ttggtaaata aagttgctgg cagtcaatgg ctgggcagga agacagaggt gggacttacc
      301 agagaattac caggtcaggg gggaccaaag gaggaagaag gagaaagact cccctttgct
      361 gagagagaag taaagaccag gcttgagaag tggaggacag agagacagcc aacatgtaag
      421 agtcaggaag agtttcatgc gtttacgaaa ttgtatcgtg tgatcttggg tatcctaagt
      481 ttctgggcta atatccactt atcagtgagt acatattgtg taagttcctt ttgattgggt
      541 tacctcactc aggatgatac ccttcaggtc catccatttg ccatggaatt tcataaatcc
      601 attcttttag tagctgagta gctatccatt gtgtaaatgt accacatttt ctgtatccat
      661 tcctctgttg gggggcatct gggttctttc cagcttttgg ctattatata ataaggctgc
      721 tataacatag tggagcatgt gtccttctta ccggttggga catcttctgg atatatgccc
      781 aggagaggta ttgtgggatc ctctggtatc aaaagatggc ctagtcgacc atcaatggaa
      841 agagaggccc attggacttg caaactttat acgccccagt acaggggaat gccagggcca
      901 aaaagtgaga gtgggtgggt aggggagtgg gggagggtat gggggacttt tgggatagca
      961 ttggaaatgt aaatgaggaa aatacctaat aaaaattaaa aaaaaaataa aatctgtact
     1021 ggaaaaaaaa agacttacga tctggagtat caggcatgac tatgtagacc tttaatctgg
     1081 aggcagtggc aggcaggtct ctgagctcca gcaagagcta tacgtagaca ttgtctcaac
     1141 ccataaaaaa aaaaaaaaaa gagtcaggaa gagtggcctg gcccccctcc aaccgcacaa
     1201 ctgggtctag ggcaacaaag atggaataca gattttagta agtaacaact caggaatatg
     1261 ggaggggaag tgttaaccac ctaaaagttt gggagtggca cagcctttga actgcttaag
     1321 acatattaaa atataaggct gcatgtgtgc atctttcact tagaacccag aacactgggg
     1381 cgagcagtta ggaacacacg tggccactgc tgggttgatt aaagaagaga ttaacggttt
     1441 cagctacaat ttccttccct tttctctctc tccaaaccct cccatgtatt actttctctt
     1501 taaaatcatg acctattatt cattagttgt tgttttacac acacacacac acacacacac
     1561 acacacacac acacacctga atttataact ggaacctgcc aacatgttca ctgagtacaa
     1621 actgagctgt aagtgcctcc agtagtttat gacaactcaa tctctgcatg actgacagtg
     1681 acctgaaaac tgaagctcgg agctagcagc ctgtccctcc caagtcaagg acgtttgtgt
     1741 ttaagacaac ataattcagc agctcacagg tttctccact cttctgatgt ttgcgtcttt
     1801 ctgtattaac gtgtttcttc ctttgaacct tactgataga aactaaattc taacagtccc
     1861 ctagctatcc aaatttagac tctctgtggc ttcagtttcc tgcagtggct catgaaactg
     1921 aatcatgtga cgccatcaaa aggaggatca ggagtacaca gtaagatggt agagagagag
     1981 aaaataggaa caaacgctaa aataactttt agcacagggc attgctgtat ttgttgtttt
     2041 attaattatt gccattaatc tcttgtcatg cctaatttat aaaataaact ttataactgg
     2101 tgtgcctata taagaaacac attgtaaata tagtcatggt tcagtatctc agtttcaggc
     2161 attcacagga cactttttaa acatgtccct ggcagacagg aagatttact taccagcaga
     2221 aaacacacat agattcccaa ctcctcctct atccatcttc ggattttgtc atggatacac
     2281 tatttccacc tgtcactgta gctgagctgt ccatgctatt accctggtga gcatttcctc
     2341 ctgaccattg catgctgtcc ttcacagagg atctctctaa atctcttcac cctctttcag
     2401 atatcacctt ccactgtcgt atttccataa gaacaaaagc atcacttttc ccatcgataa
     2461 ctaacatcct cacacataca ctcctctcac tcccttatct gttccctctc cctctctcta
     2521 taaacaactg tcttagcctt cttctctcca ctccaggatc tgctttcagc caaaactgcc
     2581 cagatgcctc tcccttgctt tttctcaatg gagagaaacc atgtccttcc agtttcttag
     2641 gctaaaagtg ttagaaacat cccaaactcc tcgcttacac tcagagccat ggacatcatc
     2701 tgaaactcac actcatagcc atggacgctc aaaccattgc agtccaatgg tttgatatat
     2761 tcttaccatt ctcagaataa acataatatt attatgttta ataattccaa ttgaactgta
     2821 agaatttcag atgccctgga aaaacatgga cattggttta gtacctaaaa gttcaaaata
     2881 ttatatattt ttaaatacca ttttacactg aaatactcca tttatatact ggggactgtc
     2941 ctctttctgg tttgctttgt tttgtttaat aaaagaaata aaccaatcta cctgaggaac
     3001 tgtgaactat attgaagaaa agcctgcacg ggggttctct taccttttca agagtgcttc
     3061 aaagaaggga aatttactga caggcaaggt ctgtacccat tgtttaattg tctgttagat
     3121 gttatgcata gaatacgtct tttaacttag ccaaatgcag aaggccaagt gcattatcta
     3181 caaacacata actctatata tagacatgtg catggccgtg tagagatgag actctgcaag
     3241 tgtgtctcta atgattcggg ggatatgagt ttgtctaatt gacctttgag agggaaacca
     3301 gactgcacat ttcatctaca aatccaacct gtttcgcaat ttctccagca ataatacttg
     3361 agtcaagctg ggccgggagc tggttaacct ccaggtcaaa ctcactggct gggcgggact
     3421 gcgcctgggc gtagattgag catgctaaat ttactctcct gtccacagaa agcccaggca
     3481 cagtggaaca gcggtttcca ggagctgctg gtcccatctt ccaaggctct agctcaactc
     3541 agagccgctt cttccaaagt ctacatcttg gtggactttg cagaggaaac cgggagtaga
     3601 gacacgtgag gtaagcattt cctaggaagg gtcgggtgtt ccggatacca gagcctggtc
     3661 cgggtgtcag cgtcctcgtg agtctgtggg gaccaagtgg cgacacaaga gtcgctccag
     3721 gagcacccgc agcatcagct ttcaggacgg tgttttccgc gccaccgctg tgctgtggat
     3781 ctcgctgccc agctcgcagc caggggtggt ggaggagcag tcgtccaggg cgaggggacc
     3841 cagcaggcgg gtggccggac ctagagccga gcacccggtc cacgcaggtg acacagcttc
     3901 ccgggattcc ccgggtgggt tacctccagg ccctctccgg cagcatcagg gcggggctcc
     3961 tcctcaccac tgggcttcgc ggggcagtga gctttgcata aactctggtc cccgtgtttg
     4021 gctaatgaac tgtggtttct ccccaggtcg tgatggaact tgaagaggac cttaagggaa
     4081 gagcagacaa gaacttctca aagatgggca aaaagaggta gccagattgt ttcactttcg
     4141 tactttactt gtcttgtaca ttcgggcaat tagtttgtag cctccagcac tgtacttgat
     4201 tagtgggtgt tatttcagac ttcagaaatg taaaccagcc cttggaagga actcctcgct
     4261 tggagcagtc cttcaaatgt gtgtgacaga tcaatcaatg attctgtgaa ttc
//