From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human DNA for endothelin-A receptor, exon 8 and 3' flanking region.
Date: 29 Dec 92 20:55:50 GMT
Distribution: bionet
Checksum: 15924 6

LOCUS       HUMETAR8     2595 bp ds-DNA             PRI       11-DEC-1992
DEFINITION  Human DNA for endothelin-A receptor, exon 8 and 3' flanking region.
ACCESSION   D11151
KEYWORDS    ET-A receptor; ET-AR; endothelin-A receptor.
SEGMENT     8 of 8
SOURCE      Homo sapiens (library: lambda EMBL3 and lambda EMBL3SP6/T7) DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Hosoda,K., Nakao,K., Tamura,N., Arai,H., Ogawa,Y., Suga,S.-.,
            Nakanishi,S. and Imura,H.
  TITLE     Organization, structure, chromosomal assignment, and expression of
            the gene encoding the human endothelin-A receptor
  JOURNAL   J. Biol. Chem. 267, 18797-18804 (1992)
  STANDARD  full automatic
COMMENT     Submitted (18-May-1992) to DDBJ by: Kiminori Hosoda Second Division
            Department of Medicine Kyoto University School of Medicine 54
            Shogoin, Kawahara-cho Sakyo-ku Kyoto 606 Japan Phone:  075-751-3170
            Fax:    075-771-9452.
FEATURES             Location/Qualifiers
     intron          <1..18
                     /number=7
     exon            19..2495
                     /number=8
     polyA_signal    2474..2479
     CDS             join(D11145:92..511,D11146:21..148,D11147:21..219,
                     D11148:21..173,D11149:21..154,D11150:21..129,19..159)
                     /product="endothelin-A receptor"
                     /codon_start=1
                     /translation="METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTE
                     LSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLL
                     RIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKL
                     FPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAI
                     PEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYT
                     LMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYN
                     EMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSK
                     SLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN"
BASE COUNT      788 a    478 c    459 g    870 t
ORIGIN      Chromosome 4.
        1 gtctgttcct tcccccagtc atgcctctgc tgctgctgtt accagtccaa aagtctgatg
       61 acctcggtcc ccatgaacgg aacaagcatc cagtggaaga accacgatca aaacaaccac
      121 aacacagacc ggagcagcca taaggacagc atgaactgac cacccttaga agcactcctc
      181 ggtactccca taatcctctc ggagaaaaaa atcacaaggc aactgtgact ccgggaatct
      241 cttctctgat ccttcttcct taattcactc ccacacccaa gaagaaatgc tttccaaaac
      301 cgcaaggtag actggtttat ccacccacaa catctacgaa tcgtacttct ttaattgatc
      361 taatttacat attctgcgtg ttgtattcag cactaaaaaa tggtgggagc tgggggagaa
      421 tgaagactgt taaatgaaac cagaaggata tttactactt ttgcatgaaa atagagcttt
      481 caagtacatg gctagctttt atggcagttc tggtgaatgt tcaatgggaa ctggtcacca
      541 tgaaacttta gagattaacg acaagatttt ctactttttt taagtgattt tttgtccttc
      601 agccaaacac aatatgggct caggtcactt ttatttgaaa tgtcatttgg tgccagtatt
      661 ttttaactgc ataatagcct aacatgatta tttgaactta tttacacata gtttgaaaaa
      721 aaaaagacaa aaatagtatt caggtgagca attagattag tattttccac gtcactattt
      781 atttttttaa aacacaaatt ctaaagctac aacaaatact acaggccctt aaagcacagt
      841 ctgatgacac atttggcagt ttaatagatg ttactcaaag aattttttaa gaactgtatt
      901 ttatttttta aatggtgttt tattacaagg gaccttgaac atgttttgta tgttaaattc
      961 aaaagtaatg cttcaatcag atagttcttt ttcacaagtt caatctgttt ttcatgtaaa
     1021 ttttgtatga aaaatcaatg tcaagtacca aaatgttaat gtatgtgtca tttaactctg
     1081 cctgagactt tcagtgcact gtatatagaa gtctaaaaca cacctaagag aaaaagatcg
     1141 aatttttcag atgattcgga aattttcatt caggtatttg taatagtgac atatatatgt
     1201 atatacatat cacctcctat tctcttaatt tttgttaaaa tgttaactgg cagtaagtct
     1261 tttttgatca ttcccttttc catataggaa acataatttt gaagtggcca gatgagttta
     1321 tcatgtcagt gaaaaataat tacccacaaa tgccaccagt aacttaacga ttcttcactt
     1381 cttggggttt tcagtatgaa cctaactccc caccccaaca tctccctccc acattgtcac
     1441 catttcaaag ggcccacagt gacttttgct gggcattttc ccagatgttt acagactgtg
     1501 agtacagcag aaaatctttt actagtgtgt gtgtgtatat atataaacaa ttgtaaattt
     1561 cttttagccc atttttctag actgtctctg tggaatatat ttgtgtgtgt gatatatgca
     1621 tgtgtgtgat ggtatgtatg gatttaatct aatctaataa ttgtgccccg cagttgtgcc
     1681 aaagtgcata gtctgagcta aaatctaggt gattgttcat catgacaacc tgcctcagtc
     1741 cattttaacc tgtagcaacc ttctgcattc ataaatcttg taatcatgtt accattacaa
     1801 atgggatata agaggcagcg tgaaagcaga tgagctgtgg actagcaata tagggttttg
     1861 tttggttggt tggtttgata aagcagtatt tggggtcata ttgtttcctg tgctggagca
     1921 aaagtcatta cactttgaag tattatattg ttcttatcct caattcaatg tggtgatgaa
     1981 attgccaggt tgtctgatat ttctttcaga cttcgccaga cagattgctg ataataaatt
     2041 aggtaagata atttgttggg ccatatttta ggacaggtaa aataacatca ggttccagtt
     2101 gcttgaattg caaggctaag aagtactgcc cttttgtgtg ttagcagtca aatctattat
     2161 tccactggcg catcatatgc agtgatatat gcctataata taagccatag gttcacacca
     2221 ttttgtttag acaattgtct ttttttcaag atgctttgtt tctttcatat gaaaaaaatg
     2281 cattttataa attcagaaag tcatagattt ctgaaggcgt caacgtgcat tttatttatg
     2341 gactggtaag taactgtggt ttactagcag gaatatttcc aatttctacc tttactacat
     2401 cttttcaaca agtaactttg tagaaatgag ccagaagcca aggccctgag ttggcagtgg
     2461 cccataagtg taaaataaaa gtttacagaa accttgcaag tgtctcttca tttttatgta
     2521 gttttccata gaaaatgttt gttacataat gcctgttgca aacctctcct tagtaatatc
     2581 ctggaaagca gttta
//