From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human profilaggrin (FLG) gene exons 1-3, 5' end.
Date: 29 Dec 92 01:00:49 GMT
Distribution: bionet
Checksum: 02600 4

LOCUS       HUMPROFIL     313 bp ss-mRNA            PRI       04-DEC-1992
DEFINITION  Human profilaggrin (FLG) gene exons 1-3, 5' end.
ACCESSION   L01090
KEYWORDS    filaggrin; profilaggrin.
SOURCE      Homo sapiens (library: lambda gt11) cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Dale,B.A., Resing,K.A. and Lonsdale-Eccles,J.D.
  TITLE     Filaggrin: A keratin filament associated protein
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 313)
  AUTHORS   Presland,R.B., Haydock,P.V., Fleckman,P., Nirunsuksiri,W. and
            Dale,B.A.
  TITLE     Characterization of the human epidermal profilaggrin gene: genomic
            organization and identification of an S-100-like calcium bindind
            domain at the amino terminus
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   Presland,R.B., Haydock,P.V., Fleckman,P., Nirunsuksiri,W. and
            Dale,B.A.
  TITLE     Characterization of the human epidermal profilaggrin gene: genomic
            organization and identification of an S-100-like calcium binding
            domain at the amino terminus
  JOURNAL   J. Biol. Chem. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            1..16
                     /number=1
                     /gene="FLG"
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
                     /partial
     exon            17..175
                     /number=2
                     /gene="FLG"
                     /citation=[2]
                     /note="putative"
     exon            176..313
                     /function="contains an S-100-like EF hand; may bind
                     calcium"
                     /standard_name="EF hand"
                     /gene="FLG"
                     /citation=[2]
                     /partial
                     /note="putative"
     CDS             38..313
                     /function="contains two S-100-like EF hands; may bind
                     calcium"
                     /standard_name="S-100-like EF hands"
                     /gene="FLG"
                     /citation=[2]
                     /partial
                     /note="putative"
                     /product="profilaggrin"
                     /codon_start=1
                     /translation="MSTLLENIFAIINLFKQYSKKDKNTDTLSKKELKELLEKEFRQI
                     LKNPDDPDMVDVFMDHLDIDHNKKIDFTEFLLMVFKLAQAYYESTRKE"
BASE COUNT      113 a     56 c     57 g     87 t
ORIGIN      
        1 ccttttggtg aacaaggttc acatttattg ccaaaagatg tctactctcc tggaaaacat
       61 ctttgccata attaatcttt tcaagcaata ttcaaaaaaa gataaaaaca ctgacacatt
      121 gagtaaaaaa gagctgaagg aacttctgga aaaggaattt cggcaaatcc tgaagaatcc
      181 agatgaccca gatatggttg atgtcttcat ggatcacttg gatatagacc acaacaagaa
      241 aattgacttc actgagtttc ttctgatggt attcaagttg gctcaagcat attatgagtc
      301 taccagaaaa gag
//