From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human hepatocyte growth factor heavy chain (HGF) gene mRNA,
Date: 29 Sep 92 10:06:39 GMT
Distribution: bionet
Checksum: 26238     4

LOCUS       HUMHGFX      1184 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human hepatocyte growth factor heavy chain (HGF) gene mRNA,
            complete cds.
ACCESSION   L02931
KEYWORDS    heavy chain; hepapoietin A; hepatocyte growth factor;
            scatter factor.
SOURCE      Homo sapiens (library: lambda gt10) embryo cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Hartmann,G., Naldini,L., Weidner,K.M., Sachs,M., Vigna,E.,
            Comoglio,P.M. and Birdmeier,W.
  TITLE     A functional domain in the heavy chain of scatter factor/hepatocyte
            growth factor binds the c-Met receptor, induces cell dissociation
            but not mitogenesis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (1992) In press
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     5'UTR           1..60
                     /gene="HGF"
     CDS             61..933
                     /product="hepatocyte growth factor"
                     /gene="HGF"
                     /codon_start=1
                     /translation="MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKK
                     SAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFN
                     SMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEH
                     SFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGES
                     YRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDP
                     HTRWEYCAIKTCET"
     sig_peptide     61..153
                     /gene="HGF"
                     /codon_start=1
     polyA_site      1184
                     /gene="HGF"
BASE COUNT      355 a    286 c    247 g    296 t
ORIGIN
        1 caggattctt tcacccaggc atctcctcca gagggatccg ccagcccgtc cagcagcacc
       61 atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc
      121 ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat
      181 gaattcaaaa aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa
      241 accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt
      301 ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc
      361 ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa
      421 aacaaagact acattagaaa ctgcatcatt ggtaaaggac gcagctacaa gggaacagta
      481 tctatcacta agagtggcat caaatgtcag ccctggagtt ccatgatacc acacgaacac
      541 agctttttgc cttcgagcta tcggggtaaa gacctacagg aaaactactg tcgaaatcct
      601 cgaggggaag aagggggacc ctggtgtttc acaagcaatc cagaggtacg ctacgaagtc
      661 tgtgacattc ctcagtgttc agaagttgaa tgcatgacct gcaatgggga gagttatcga
      721 ggtctcatgg atcatacaga atcaggcaag atttgtcagc gctgggatca tcagacacca
      781 caccggcaca aattcttgcc tgaaagatat cccgacaagg gctttgatga taattattgc
      841 cgcaatcccg atggccagcc gaggccatgg tgctatactc ttgaccctca cacccgctgg
      901 gagtactgtg caattaaaac atgcgagaca taacatgggc tctcaactga tggtgaactt
      961 cttctggtga gtgacagagg ctgcagtgaa gaataatgag tctaatagaa gtttatcaca
     1021 gatgtctcta atctttatag ctgatcccta cctctctcgc tgtctttgta cccagcctgc
     1081 attctgtttc gatctgtctt ttagcagtcc atacaatcat ttttctacat gctggccctt
     1141 acctagcttt tctgaattta caataaaaac tattttttaa cgtg
//