From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.lar immunoglobulin alpha-2 constant region gene for
Date: 28 Jul 92 10:02:53 GMT
Distribution: bionet
Checksum: 52848     7

LOCUS       GIBIGA2C     2981 bp ds-DNA             PRI       28-JUL-1992
DEFINITION  H.lar immunoglobulin alpha-2 constant region gene for
            alpha-immunoglobulin heavy-chain constant region
ACCESSION   X53709
KEYWORDS    direct repeat; hinge region; immunoglobulin alpha-2;
            immunoglobulin-alpha heavy-chain constant (C) region.
SOURCE      Hylobates lar DNA.
  ORGANISM  Hylobates lar
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hylobatidae.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Kawamura,S., Tanabe,H., Watanabe,Y., Kurosaki,K., Saitou,N.,
            Omoto,K. and Ueda,S.
  JOURNAL   Mol. Biol. Evol. 8, 793-793 (1991)
  STANDARD  simple staff_entry
COMMENT     *source: cell_type=leucocyte; *source: clone_library=genomic;
            *source: clone=ch28.HL.Ig epsillon-alpha.7; *source: is_germline=Y;
            related sequence: X53388
            From EMBL    entry HLIGA2C;  dated 29-NOV-1991.
FEATURES             Location/Qualifiers
     5'UTR           <1..289
     mRNA            join(290..595,809..1129,1341..1738)
                     /gene="immunoglobulin alpha-2 constant region"
     CDS             join(290..595,809..1129,1341..1738)
                     /product="alpha-immunoglobulin heavy-chain constant
                     region"
                     /gene="immunoglobulin alpha-2 constant region"
                     /codon_start=3
                     /translation="SPTSPKVFPLSLDSTQPDGNVVVACLVQGFFPQEPLNVTWSESG
                     QNVTATNFPPSQDASGGLYTTSSQLTLPATECLAGKSVTCHVEHYTNPSQDVTVPCRA
                     PPPHPCCQPRLSLQRPALEDLLFGSEANLTCTLTGLRDASGATFTWTPSSGKNAVQGL
                     PERDLCGCYSVSSILPGCAQPWNNRETFTCTAEHPELKTPLTANITKSGKNKFRPEVH
                     LLPPPSEELALNELVTLTCLARGFSPEDVLVRWLQGSQELPREKYLTWASRQEPSQGT
                     TTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAE
                     VDGTCY"
                     /partial
     exon            290..595
                     /number=1
                     /note="CH1"
     intron          596..808
                     /number=1
     repeat_region   795..809
                     /rpt_type=direct
                     /note="hinge region"
     exon            809..1129
                     /number=2
                     /note="CH2"
     repeat_region   810..824
                     /rpt_type=direct
                     /note="hinge region"
     intron          1130..1340
                     /number=2
     exon            1341..1738
                     /number=3
                     /note="CH3"
     polyA_signal    1763..1768
BASE COUNT      598 a   1001 c    897 g    485 t
ORIGIN
        1 gagctcaggg gactcagcca ctccatgcag agccctgttt aatacaactt gtgtctggga
       61 cggcctgggt cagagaccct atctaaggag catgttcaga aaccatgtcg ctaggatcag
      121 acagcagggt ccaaccgcag gcccgtggtg caggagctgt gtgaccttgg ggccgtcacc
      181 aggcctctct gtgctgggtt tctccagtgc agaggagagg caggcacagc ctgtcctcct
      241 ggggacatgg catgagggcc gcgtcctcac agcgcattct gtgttccagc atccccgacc
      301 agccccaagg tcttcccgct gagcctcgac agcacccagc cagatgggaa cgtggtcgtc
      361 gcctgcctgg tccagggctt cttcccccag gagccgctca atgtgacctg gagtgaaagc
      421 ggacagaacg tgaccgccac aaacttccca cccagtcagg atgcctccgg gggcctgtac
      481 accacgagca gccagctgac cctaccggcc acagagtgcc tggccggcaa atccgtgaca
      541 tgccacgtgg agcactacac gaatcccagc caggatgtga ctgtgccctg cagaggtcag
      601 agggcaggct ggggagtggg gcggggccac cccatcctgc cctaacactg cgcctggacc
      661 cgtttccccc cagggtgccg ccccgtcact cacaacagag ttgactgcgg gccgagcccc
      721 aggaggtggt ggtggacagg ccaggagggg caaggcaggg gcacggggaa gggcgtgctg
      781 accagctcag gccatctctc cactccagct cccccacctc acccatgctg ccagccccga
      841 ctgtcgctgc agcgaccagc cctcgaggac ctgctctttg gttcagaagc gaacctcacg
      901 tgcacactga ccggcctgag agatgcctca ggtgccacat tcacctggac accctcaagt
      961 gggaagaacg ctgttcaagg actacctgag cgtgacctct gtggctgcta cagcgtgtcc
     1021 agtatcctgc ccggctgtgc ccagccatgg aataataggg agaccttcac ctgcactgct
     1081 gagcaccccg agttgaagac cccgctaacc gccaacatca caaaatccgg tgggtcgggg
     1141 ccctgctcag tgtcctggtt tgcacagcat attcccagcc tgcctcctcc ctcccagtcc
     1201 tgggctcagg tgatcatgcc aagtacagag ggaaactgag gcaggctgag ggggccagga
     1261 cacagcctgg ggagcccacc agagcagagg ggctctctca tcccctgccc agccccctga
     1321 cctggctctc taccctccag gaaaaaacaa gttccggccc gaggtccacc tgctgccgcc
     1381 gccgtcggag gagctggccc tgaacgagct ggtgacgctg acgtgcctgg cacgcggctt
     1441 cagccccgag gatgtgctgg ttcgctggct gcaggggtca caagagctgc cccgtgagaa
     1501 gtacctgact tgggcatccc ggcaggagcc cagccagggc accaccacct tcgctgtgac
     1561 cagcatactg cgcgtggcag ccgaggactg gaagaagggg gacaccttct cctgcatggt
     1621 gggccacgag gccctgccgc tggccttcac acagaagacc atcgaccgcc tggcgggtaa
     1681 acccacccac gtcaatgtgt ctgtggtcat ggcagaggtg gacggcacct gctactgagc
     1741 cacctgcctg tccccagccc tgaataaact ccatgctccc ccaagcagcc ccacgcttcc
     1801 atccggcgcc tgtctgtcca tcctcagggt ctcagcacat gggaaagggc cagggcacgg
     1861 ggggtacagc accccctgcc ctgagccttg gggggcccct ggcaccccca tgagcctttc
     1921 caccctggtg tgagtgagtt gtgagtgtga gagcgtgtgg tgcaggaggc ctcgctggtg
     1981 cgaaatctta ggtttgccga ggcaggcaca gcccagggtg ggttctgaga gacacacatg
     2041 ccccggagag ttctgagtgg gcagtggcat ggacgtttgt ccctgagaca gcagcctctg
     2101 gctgcagctg ggagggaata gggagggtga gaggagcagc ctggccaaga aagacgcaca
     2161 tagtgggagg agcggcgagg gagtgagggg ctggactcca gggccccact gggaggacaa
     2221 gctccaggag ggccccacca ccctagtggg tgggcctcag gacgtcctac tgacgcatgc
     2281 agaaaggggc acctccccct aaccacatta ctctgtaagg ggcacgtggg cacacgtgca
     2341 cactcacact cacatacacg cctgatccct gcaggagcag aacgttcaca gcccagacac
     2401 agctccagaa aggacaaggg agtcccctcc caagccccca tggacattcc caggctcagc
     2461 ctgctgcccc aggcccctct ggcctccctg tgtttccact gtgcactgct cagggacgaa
     2521 ctccacagac ccctcccagg cagcccctgc tccctgcctg gccaagtctc ccatcccttc
     2581 ctaagcccaa ctaggaccca aagcatagac agggaagggc cgcgtggggt ggcatcagaa
     2641 gcaggccagt gagacagggc ctgccctggg ccctctgcat gcctctggct tctgcctggg
     2701 gctcccagga gtggaagaac agtcccacaa ccactgtggg gacacctggc accaggactc
     2761 ccacaagggg gcagtggggc ccctgctcat gccttagaca tcctccaggc ctccccaggg
     2821 gcccccgcct tctggctgcc tccctctgct ctcagggcca aggtgagaca gaggccactg
     2881 tcacccctga gggtccagtc accagagggt aattcagagc aacaggtcac tcggggaagc
     2941 cctgccacag agaagccctc cagcccatgg gacccaggac c
//