From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human E2A/HLA fusion protein (E2A/HLF) mRNA, complete cds.
Date: 18 Aug 92 10:02:26 GMT
Distribution: bionet
Checksum: 36919     8

LOCUS       HUME2AHLF    4410 bp ss-mRNA            PRI       18-AUG-1992
DEFINITION  Human E2A/HLA fusion protein (E2A/HLF) mRNA, complete cds.
ACCESSION   M95586
KEYWORDS    E2A/HLF fusion protein.
SOURCE      Homo sapiens female leukemia cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4410)
  AUTHORS   Inaba,T., Roberts,W.M., Shapiro,L.H., Jolly,K.W., Raimondi,S.C.,
            Smith,S.D. and Look,A.T.
  TITLE     Fusion of the leucine zipper gene HLF to the E2A gene in human
            acute B-lineage leukemia
  JOURNAL   Science 257, 531-534 (1992)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     5'UTR           <1..30
     mRNA            <1..4410
                     /evidence=EXPERIMENTAL
     CDS             31..1755
                     /function="unknown"
                     /product="E2A/HLF fusion protein"
                     /gene="E2A/HLF"
                     /evidence=EXPERIMENTAL
                     /codon_start=1
                     /translation="MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQ
                     FGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKS
                     GERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRR
                     AADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVAD
                     GSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGY
                     QLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGK
                     ALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSK
                     IEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTSPMSLGGRHAGLVGGSHPED
                     GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGQGISPQLGPLSTSIYLLTQDDKYW
                     ARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAK
                     YEARHGPL"
     3'UTR           1753..4410
                     /note="putative"
     polyA_site      4387..4392
BASE COUNT     1088 a   1116 c   1046 g   1160 t
ORIGIN
        1 gcctgaggtg cccgccctgg ccccaggaga atgaaccagc cgcagaggat ggcgcctgtg
       61 ggcacagaca aggagctcag tgacctcctg gacttcagca tgatgttccc gctgcctgtc
      121 accaacggga agggccggcc cgcctccctg gccggggcgc agttcggagg ttcaggtctt
      181 gaggaccggc ccagctcagg ctcctggggc agcggcgacc agagcagctc ctcctttgac
      241 cccagccgga ccttcagcga gggcacccac ttcactgagt cgcacagcag cctctcttca
      301 tccacattcc tgggaccggg actcggaggc aagagcggtg agcggggcgc ctatgcctcc
      361 ttcgggagag acgcaggcgt gggcggcctg actcaggctg gcttcctgtc aggcgagctg
      421 gccctcaaca gccccgggcc cctgtcccct tcgggcatga aggggacctc ccagtactac
      481 ccctcctact ccggcagctc ccggcggaga gcggcagacg gcagcctaga cacgcagccc
      541 aagaaggtcc ggaaggtccc gccgggtctt ccatcctcgg tgtacccacc cagctcaggt
      601 gaggactacg gcagggatgc caccgcctac ccgtccgcca agacccccag cagcacctat
      661 cccgccccct tctacgtggc agatggcagc ctgcacccct cagccgagct ctggagtccc
      721 ccgggccagg cgggcttcgg gcccatgctg ggtgggggct catccccgct gcccctcccg
      781 cccggtagcg gcccggtggg cagcagtgga agcagcagca cgtttggtgg cctgcaccag
      841 cacgagcgta tgggctacca gctgcatgga gcagaggtga acggtgggct cccatctgca
      901 tcctccttct cctcagcccc cggagccacg tacggcggcg tctccagcca cacgccgcct
      961 gtcagcgggg ccgacagcct cctgggctcc cgagggacca cagctggcag ctccggggat
     1021 gccctcggca aagcactggc ctcgatctac tccccggatc actcaagcaa taacttctcg
     1081 tccagccctt ctacccccgt gggctccccc cagggcctgg caggaacgtc acagtggcct
     1141 cgagcaggag cccccggtgc cttatcgccc agctacgacg ggggtctcca cggcctgcag
     1201 agtaagatag aagaccacct ggacgaggcc atccacgtgc tccgcagcca cgccgtgggc
     1261 acagccggcg acatgcacac gctgctgcct ggccacgggg cgctggcctc aggtttcacc
     1321 agtcccatgt cgctgggtgg gcggcacgca ggcctggttg gaggcagcca ccccgaggac
     1381 ggcctcgcag gcagcaccag cctcatgcac aaccacgcgg ccctccccag ccagccaggc
     1441 accctccctg acctgtctcg gcctcccgac tcctacagtg gccagggcat ctcaccgcag
     1501 cttggtcccc tctccacctc gatctacttg ctcacccagg atgacaagta ctgggcaagg
     1561 cgcagaaaga acaacatggc agccaagcgc tcccgcgacg cccggaggct gaaagagaac
     1621 cagatcgcca tccgggcctc gttcctggag aaggagaact cggccctccg ccaggaggtg
     1681 gctgacttga ggaaggagct gggcaaatgc aagaacatac ttgccaagta tgaggccagg
     1741 cacgggcccc tgtaggatgg catttttgca ggctggcttt ggaatagatg gacagtttgt
     1801 ttcctgtctg atagcaccac acgcaaacca acctttctga catcagcact ttaccagagg
     1861 cataaacaca actgactccc attttggtgt gcatctgtgt gtgtgtgcgt gtatatgtgc
     1921 ttgtgctcat gtgtgtggtc agcggtatgt gcgtgtgcgt gttcctttgc tcttgccatt
     1981 ttaaggtagc cctctcatcg tcttttagtt ccaacaaaga aaggtgccat gtctttacta
     2041 gactgaggag ccctctcgcg ggtctcccat cccctccctc cttcactcct gcctcctcag
     2101 ctttgcttca tgttcgagct tacctactct tccaggactc tctgcttgga ttcactaaaa
     2161 agggccctgg taaaatagtg gatctcagtt tttaagagta caagctcttg tttctgttta
     2221 gtccgtaagt taccatgcta atgaggtgca cacaataact tagcactact ccgcagctct
     2281 agtcctttat aagttgcttt cctcttactt tcagttttgg tgataatcgt cttcaaatta
     2341 aagtgctgtt tagatttatt agatcccata tttacttact gctatctact aagtttcctt
     2401 ttaattctac caaccccaga taagtaagag tactattaat agaacacaga gtgtgttttt
     2461 gcactgtctg tacctaaagc aataatccta ttgtacgcta gagcatgctg cctgagtatt
     2521 actagtggac gtaggatatt ttccctacct aagaatttca ctgtctttta aaaaacaaaa
     2581 agtaaagtaa tgcatttgag catggccaga ctattcccta ggacaaggaa gcagagggaa
     2641 atgggaggtc taaggatgag gggttaattt atcagtacat gagccaaaaa ctgcgtcttg
     2701 gattagcctt tgacattgat gtgttcggtt ttgttgttcc ccttccctca caccctgcct
     2761 cgcccccact tttctagtta actttttcca tatccctctt gacattcaaa acagttactt
     2821 aagattcagt tttcccactt tttggtaata tatatatttt tgtgaattat actttgttgt
     2881 ttttaaaaag aaaatcagtt gattaagtta ataagttgat gttttctaag gccctttttc
     2941 ctagtggtgt catttttgaa tgcctcataa attaatgatt ctgaagctta tgtttcttat
     3001 tctctgtttg cttttgaacg tatgtgctct tataaagtgg acttctgaaa aatgaatgta
     3061 aaagacactg gtgtatctca gaaggggatg gtgttgtcac aaactgtggt taatccaatc
     3121 aatttaaatg tttactatag accaaaagga gagattatta aatcgtttaa tgtttataca
     3181 gagtaattat aggaagttct tttttgtaca gtatttttca gatataaata ctgacaatgt
     3241 attttggaag acatatatta tatatagaaa agaggagagg aaaactattc catgttttaa
     3301 aattatatag caaagatata tattcaccaa tgttgtacag agaagaagtg cttgggggtt
     3361 tttgaagtct ttaatatttt aagccctatc actgacacat cagcatgttt tctgctttaa
     3421 attaaaattt tatgacagta tcgaggcttg tgatgacgaa tcctgctcta aaatacacaa
     3481 ggagctttct tgtttcttat taggcctcag aaagaagtca gttaacgtca cccaaaagca
     3541 caaaatggat tttagtcaaa tatttattgg atgatacagt gttttttagg aaaagcatct
     3601 gccacaaaaa tgttcacttc gaaattctga gttcctggaa tggcacgttg ctgccagtgc
     3661 cccagacagt tcttttctac cctgcgggcc cgcacgtttt atgaggttga tatcggtgct
     3721 atgtgtttgg tttataattt gatagatgtt tgactttaaa gatgattgtt cttttgtttc
     3781 attaagttgt aaaatgtcaa gaaattctgc tgttacgaca aagaaacatt ttacgctaga
     3841 ttaaaatatc ctttcatcaa tgggattttc tagtttcctg ccttcagagt atctaatcct
     3901 ttaatgatct ggtggtctcc tcgtcaatcc atcagcaatg cttctctcat agtgtcatag
     3961 acttgggaaa cccaaccagt aggatatttc tacaaggtgt tcattttgtc acaagctgta
     4021 gataacagca agagatgggg gtgtattgga attgcaatac attgttcagg tgaataataa
     4081 aatcaaaaac ttttgcaatc ttaagcagag ataaataaaa gatagcaata tgagacacag
     4141 gtggacgtag agttggcctt tttacaggca aagaggcgaa ttgtagaatt gttagatggc
     4201 aatagtcatt aaaaacatag aaaaatgatg tctttaagtg gagaattgtg gaaggattgt
     4261 aacatggacc atccaaattt atggccgtat caaatggtag ctgaaaaaac tatatttgag
     4321 cactggtctc tcttggaatt agatgtttat atcaaatgag catctcaaat gttttctgca
     4381 gaaaaaaata aaaagattct aataaaaaaa
//