From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens mRNA for epithelin 1 and 2
Date: 11 Sep 92 10:04:24 GMT
Distribution: bionet
Checksum: 24996     6

LOCUS       HUMEPIT1     2152 bp ss-RNA             PRI       11-SEP-1992
DEFINITION  H.sapiens mRNA for epithelin 1 and 2
ACCESSION   X62320
KEYWORDS    Epithelin 1; Epithelin 2; epithelial cell growth regulator;
            soluble protein.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Plowman,G.D.
  JOURNAL   Unpublished (1991)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Plowman,G.D., Green,J.M., Neubauer,M.G., Buckley,S.D.,
            McDonald,V.L., Todaro,G.J. and Shoyab,M.
  TITLE     The epithelin precursor encodes teo proteins with opposing
            activities on epithelial cell growth
  JOURNAL   J. Biol. Chem. 267, 13073-13078 (1992)
  STANDARD  full staff_review
COMMENT     *source: tissue=kidney; *source: clone_library=PCR clones in
            Bluescript;
            See also X62320-2
            From EMBL    entry HSEPIT1;  dated 26-AUG-1992.
FEATURES             Location/Qualifiers
     sig_peptide     41..91
     CDS             41..1822
                     /product="Epithelin 1 & 2"
                     /codon_start=1
                     /translation="MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRP
                     LLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRG
                     FHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCED
                     RVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDG
                     STCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPA
                     HTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGT
                     CEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIP
                     EAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSC
                     PVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFL
                     ARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCA
                     ARGTKCLRREAPRWDAPLRDPALRQLL"
     mat_peptide     92..1819
                     /product="Epithelin 1 & 2"
     misc_feature    215..382
                     /note="cysteine motif 1"
     misc_feature    392..394
                     /note="pot. glycosylation site"
     misc_feature    410..580
                     /note="cysteine motif 2"
     misc_feature    656..826
                     /note="Epithelin 2"
     misc_feature    746..748
                     /note="pot. glycosylation site"
     misc_feature    833..835
                     /note="pot. glycosylation site"
     misc_feature    884..1051
                     /note="Epithelin 1"
     misc_feature    1130..1294
                     /note="cysteine motif 5"
     misc_feature    1142..1144
                     /note="pot. glycosylation site"
     misc_feature    1364..1531
                     /note="cysteine motif 6"
     misc_feature    1595..1762
                     /note="cysteine motif 7"
     misc_feature    1628..1630
                     /note="pot. glycosylation site"
BASE COUNT      394 a    691 c    639 g    428 t
ORIGIN
        1 gctgctgccc aaggaccgcg gagtcggacg caggcagacc atgtggaccc tggtgagctg
       61 ggtggcctta acagcagggc tggtggctgg aacgcggtgc ccagatggtc agttctgccc
      121 tgtggcctgc tgcctggacc ccggaggagc cagctacagc tgctgccgtc cccttctgga
      181 caaatggccc acaacactga gcaggcatct gggtggcccc tgccaggttg atgcccactg
      241 ctctgccggc cactcctgca tctttaccgt ctcagggact tccagttgct gccccttccc
      301 agaggccgtg gcatgcgggg atggccatca ctgctgccca cggggcttcc actgcagtgc
      361 agacgggcga tcctgcttcc aaagatcagg taacaactcc gtgggtgcca tccagtgccc
      421 tgatagtcag ttcgaatgcc cggacttctc cacgtgctgt gttatggtcg atggctcctg
      481 ggggtgctgc cccatgcccc aggcttcctg ctgtgaagac agggtgcact gctgtccgca
      541 cggtgccttc tgcgacctgg ttcacacccg ctgcatcaca cccacgggca cccaccccct
      601 ggcaaagaag ctccctgccc agaggactaa cagggcagtg gccttgtcca gctcggtcat
      661 gtgtccggac gcacggtccc ggtgccctga tggttctacc tgctgtgagc tgcccagtgg
      721 gaagtatggc tgctgcccaa tgcccaacgc cacctgctgc tccgatcacc tgcactgctg
      781 cccccaagac actgtgtgtg acctgatcca gagtaagtgc ctctccaagg agaacgctac
      841 cacggacctc ctcactaagc tgcctgcgca cacagtgggg gatgtgaaat gtgacatgga
      901 ggtgagctgc ccagatggct atacctgctg ccgtctacag tcgggggcct ggggctgctg
      961 cccttttacc caggctgtgt gctgtgagga ccacatacac tgctgtcccg cggggtttac
     1021 gtgtgacacg cagaagggta cctgtgaaca ggggccccac caggtgccct ggatggagaa
     1081 ggccccagct cacctcagcc tgccagaccc acaagccttg aagagagatg tcccctgtga
     1141 taatgtcagc agctgtccct cctccgatac ctgctgccaa ctcacgtctg gggagtgggg
     1201 ctgctgtcca atcccagagg ctgtctgctg ctcggaccac cagcactgct gcccccaggg
     1261 ctacacgtgt gtagctgagg ggcagtgtca gcgaggaagc gagatcgtgg ctggactgga
     1321 gaagatgcct gcccgccggg cttccttatc ccaccccaga gacatcggct gtgaccagca
     1381 caccagctgc ccggtggggc agacctgctg cccgagcctg ggtgggagct gggcctgctg
     1441 ccagttgccc catgctgtgt gctgcgagga tcgccagcac tgctgcccgg ctggctacac
     1501 ctgcaacgtg aaggctcgat cctgcgagaa ggaagtggtc tctgcccagc ctgccacctt
     1561 cctggcccgt agccctcacg tgggtgtgaa ggacgtggag tgtggggaag gacacttctg
     1621 ccatgataac cagacctgct gccgagacaa ccgacagggc tgggcctgct gtccctaccg
     1681 ccagggcgtc tgttgtgctg atcggcgcca ctgctgtcct gctggcttcc gctgcgcagc
     1741 caggggtacc aagtgtttgc gcagggaggc cccgcgctgg gacgcccctt tgagggaccc
     1801 agccttgaga cagctgctgt gagggacagt actgaagact ctgcagccct cgggacccca
     1861 ctcggagggt gccctctgct caggcctccc tagcacctcc ccctaaccaa attctccctg
     1921 gaccccattc tgagctcccc atcaccatgg gaggtggggc ctcaatctaa ggccttccct
     1981 gtcagaaggg ggttgtggca aaagccacat tacaagctgc catcccctcc ccgtttcagt
     2041 ggaccctgtg gccaggtgct tttccctatc cacaggggtg tttgtgtgtg tgcgcgtgtg
     2101 cgtttcaata aagtttgtac actttcaaaa aaaaaaaaaa aaaaaaaaaa aa
//