From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: M.musculus mRNA for son of sevenless 2.
Date: 10 Sep 92 10:34:07 GMT
Distribution: bionet
Checksum: 18184    10

LOCUS       MUSSOS2M     5253 bp ss-RNA             ROD       10-SEP-1992
DEFINITION  M.musculus mRNA for son of sevenless 2.
ACCESSION   Z11664
KEYWORDS    son of sevenless; son of sevenless 2.
SOURCE      Mus musculus RNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 5253)
  AUTHORS   Bowtell,D.D.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 3894)
  AUTHORS   Bowtell,D., Fu,P., Simon,M. and Senior,P.
  TITLE     Identification of murine homologues of the Drosophila son of
            sevenless gene: Potential activators of ras
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 6511-6515 (1992)
  STANDARD  full automatic
COMMENT     *source: strain=Random bred Swiss; *source: stage=embryonic day 17;
            *source: tissue=eye; *source: clone_library=D.Bowtell unpublished.;
            *source: clone=Clone 10 mSos2; *source: is_macronuclear=N; *source:
            is_proviral=N; *source: is_germline=N;
            From EMBL    entry MMSOS2M;  dated 20-AUG-1992.
FEATURES             Location/Qualifiers
     CDS             <1..3894
                     /function="putative guanine nucleotide exchangefactor"
                     /note="Sequence extends to within 85 amino acidsof the
                     amino terminal end of the Drosophila Son ofsevenless
                     gene."
                     /product="son of sevenless 2"
                     /codon_start=1
                     /translation="PTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFP
                     HPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYI
                     SADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSS
                     GELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHE
                     LTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFS
                     KLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKLKACSEEQEDKE
                     CLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNI
                     DGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAE
                     YRLKEKFVMRKIQICDKEDACEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLH
                     YRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKG
                     GTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKL
                     ALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLESFIS
                     SVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLM
                     TLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF
                     EKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEAL
                     QERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRK
                     GKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYL
                     FNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYK
                     ISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLL
                     PHSKTFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPP
                     PPKVKPRVPVLMGTFDGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPL
                     GHPHRDPDWLRDVSTCPNSPSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQN
                     SSPLLPKLPPKTYKRELSHPPLYRLPLLENAETPQ"
     polyA_signal    5228..5233
     polyA_site      5253
BASE COUNT     1606 a   1125 c   1097 g   1425 t
ORIGIN
        1 cccaccctct cagctaatga agagtctctc tattatattg aagaactgat ttttcagctg
       61 cttaataagc tatgcatggc tcaaccaagg actgttcaag atgttgagga acgagttcaa
      121 aagacctttc ctcatcctat tgataaatgg gcaattgctg atgcacaatc tgctatagag
      181 aaacgaaaac gaagaaatcc tctcttacta cctgtggaca aaatccatcc ttccttgaag
      241 gaagttttgg ggtataaagt ggactaccat gtgtccctct acattgtggc tgtattggag
      301 tatatctcag cagatatttt gaaattggct ggtaattatg tttttaatat ccggcattat
      361 gaaatatctc agcaagacat taaagtgtcc atgtgtgcag ataaggtttt gatggacatg
      421 ttcgatcagg atgatgatat aggcttggtt tctctctgtg aagatgagcc ttgttcttct
      481 ggtgagctaa actattatga cctcgtcagg actgaaattg cagaagaaag acagtatcta
      541 cgggagctga atatgatcat taaagtgttc cgggaagcct ttctcttgga cagaaagttg
      601 ttcaagcctt ctgaaattga aaagattttc agtaacattt cagatataca tgaattgact
      661 gtgaaacttt taggtttaat tgaagacaca gtagaaatga cagatgaaag tagtcctcat
      721 ccattagctg gtagctgttt tgaagattta gcagaggagc aagcgtttga tccctatgaa
      781 acattatcac aggacattct tgcaccagag tttaatgacc acttcagcaa gttgatggcc
      841 agacctgcag tcgctctaca ttttcagtcc attgctgacg gctttaagga ggctgttcgt
      901 tatgtccttc cacgcctcat gctggttccc gtgtatcact gttggcatta ctttgaatta
      961 ttaaagttga aggcatgcag tgaagagcag gaggacaaag agtgtttgaa tcaggctata
     1021 actgccctca tgaacctcca aggcagcatg gaccgcattt acaagcagca ctcccccaga
     1081 cgccggcctg gggatccagt ttgccttttt tacaatcgtc aattaagaag caaacacctg
     1141 gctatcaaaa aaatgaatga aattcagaaa aacatagatg ggtgggaagg caaagatatc
     1201 ggacagtgtt gtaatgagtt cataatggag gggccactga ccagaattgg tgctaaacac
     1261 gaaaggcata tctttctctt tgatggctta atgatcagct gtaaacccaa tcatggccag
     1321 acccggcttc caggatatag cagtgcagaa tacagattaa aggagaagtt tgtcatgagg
     1381 aaaattcaaa tctgtgataa ggaagacgcc tgtgagtaca gacatgcttt tgaattagtg
     1441 tccaaagatg aaaacagtgt aatatttgct gccaaatcag ctgaagagaa aaacaactgg
     1501 atggcagccc tcatttccct gcactatcgc agcactctag acagaatgct ggactctgtg
     1561 ctgctgaaag aagagaatga gcagcccctg aggctaccca gtccagatat gtatcgcttt
     1621 gtggtaacag actctgagga aaacattgtg tttgaagaca acttgcaaag cagaagtggg
     1681 atccccataa ttaaaggagg cactgtggtg aagttgatcg aaaggctaac ataccacatg
     1741 tatgcagatc ccaattttgt tcgtactttt cttactacat atcgttcatt ttgtaaacca
     1801 caggaattgc taaacttgct gatagaacgg tttgaaattc cagaaccaga acctactgag
     1861 gcagacaagc tggcgttaga aaaaggcgag cagccaatca gcgcagatct gaaaagattc
     1921 cgcaaggaat acgtccaacc tgtgcagctt agggtcttga atgtctttcg ccactgggtt
     1981 gagcatcatt attatgactt tgaaagagac ttggaactgc ttgaaagact agaatccttc
     2041 atttcaagtg taagagggaa agccatgaag aaatgggtag aatccattgc taaaataatc
     2101 aagaggaaga agcaagctca ggcaaatgga ataagccata atatcacctt tgaaagttcc
     2161 cccccaccag tggaatggca catcagtaga acaggacagt tcgaaacatt tgaccttatg
     2221 acacttcatc caatagagat cgcacggcag ctaacacttt tggaatctga cctctacagg
     2281 aaagtccagc cctctgaact tgtagggagt gtctggacca aagaagataa agaaataaat
     2341 tctccaaact tattaaaaat gattcgccat acaacaaacc tcactctatg gtttgagaaa
     2401 tgcattgtgg aagcagaaaa ctttgaagaa cgggtggcag tgctcagcag aatagtagaa
     2461 attctgcaag tatttcaaga cttgaataat ttcaatggcg tgttggagat agtgagtgca
     2521 gtcaactccg tgtcagtgta caggctagac cacacgtttg aggcactgca ggaaaggaag
     2581 cggagaattt tggatgacgc tgtggaacta agtcaggacc actttaaaaa gtacctagta
     2641 aaacttaagt caatcaatcc gccttgtgtg cctttttttg gaatatattt aacaaatatt
     2701 ctgaagactg aagaagggaa cagtgacttt ctaaagagga aagggaaaga tttgatcaat
     2761 ttcagtaaga ggaggaaagt ggctgaaata actggagaga tccagcagta tcagaaccaa
     2821 ccgtactgct tacggacaga accagaaatg aggagattct ttgaaaacct caaccccatg
     2881 ggaattttat ctgaaaaaga gtttacagat tatttgttca acaaatcatt agaaatcgaa
     2941 ccccgaaact gcaaacaacc acctcgattt cctaggaagt caaccttttc cttaaaatct
     3001 cctggaataa ggcccaatgc tggccgccat ggctctacct caggcacgct acgaggtcac
     3061 ccaacgcctc tggaaagaga gccttataag ataagcttta gccggatcgc tgagacagag
     3121 ctagaatcaa cagtgtctgc accaacctcc cccaacactc catccacccc accagtgtct
     3181 gcttcttcag accacagcgt gtttctagat gtggacctca atagctcctg tggcagcaac
     3241 accatctttg ctccagtcct cttgccacac tcaaagactt tcttcagctc atgtggaagt
     3301 ttacacaaac tgagtgaaga gccactaatt cctcctccgc ttccccctcg gaaaaagttt
     3361 gatcatgatg ctctcaattc caagggagct gtgaaatctg atgatgaccc tcctgctatt
     3421 ccaccaagac agccccctcc tccgaaggta aagccaagag ttcctgtcct catgggtaca
     3481 tttgatgggc ctgtgcccag tccacctcca cctcctccaa gagaccctct tcctgatacc
     3541 cctccaccag ttcctcttcg gcctccggaa cactttataa actgtccatt taatcttcag
     3601 ccgcctccac tgggccatcc tcacagagac ccagactggc tcagagacgt cagcacgtgt
     3661 cctaactcac caagcactcc tcccactacg ccctctccac ggattccacg cagctgtcac
     3721 ttgctcagct ccagtcacag cagccttgct catcttccag ctcctcctgt cccaccaagg
     3781 cagaattcaa gccctctctt accaaagctg ccaccaaaga cttacaaacg ggagctttcc
     3841 cacccgccac tgtatagact gcctctgctg gaaaatgcag aaactcctca atgaccttgg
     3901 ccatatgtag tcattgacac tggaatagta tttgtaaagg tttttaattt attcaaaaag
     3961 acatagtatt ttagtacttt ttacagaaat gctactgatt aaataagctc ttaagaatta
     4021 gtaaacttgt tggatggcag tggcccacag ctgtaatccc agcaccctgg ttgcaggggc
     4081 agtgggcttc agggtttgag agcagcctgg tctacagagc aagtcccagg acagccaggg
     4141 ctacacaaaa aaaccttgtc tcaaaagtca aaatacaaac aaaagagaga aaaggaagga
     4201 aggaaagaat ttgaaatatt aaaatgcaaa agcccttcac catagccccc aggtgatcag
     4261 cagcattgct tcctcggctc ctcagtgctg ccctaggcca gtataaagac tgtattgcac
     4321 tgtagactct gctagcagac ggcactgaga ggagccagcg ctcgagggcc gttctcacgc
     4381 ctgactgata gatacctttt tagggtgatg aacttacaca gatgcagaag atatggggtg
     4441 gtggtcctgg gttttaaccc tctgaccgtc ttctagcttc taattttgtt tggtttttac
     4501 atctaggaga cttaggaata atacccgctg ttcttaaact ctttgagacc atgtcttaaa
     4561 tgtcagtatt tgctgctgaa gacaaaaacg gaaaatagaa tgaaataata gaatgcactg
     4621 tgtttattat tttgttaaaa ttataaacag ttctacataa cctgattata gaagaagggc
     4681 atgtgttcat taagatgtgc cttttgtttt gcagtgtatg gtgtttagct aatcattgtt
     4741 tagctaatga tttgcctatt atttgggaag acaaaattaa tatgccatat atgtacagtt
     4801 tatttatatt gtatatattt aaagataatg ctaataacct ctataaatgt aagtgacttg
     4861 aggcctataa tacaatctgc tatttgacta atttgtaagt ctggaacaaa agtgtcttat
     4921 ggcataagaa ccaactgcca ttgtcaaacc tattaactgt ctttaatctc gtgttaactg
     4981 aaatttttga aaagtttttc cagattagta atatttaaac agaaaatact ttaaaaagct
     5041 ttattaaatt ttttaatcag acaggataaa gctttgccat ttggatacta tcattcaaag
     5101 tgatcaaggt atgtatgtta tgctgatagt gcagtagcag ccattgtaaa gtagccaaaa
     5161 gccacgttgt ttatctactg gtctgtggcc ttttactgtg ctttgtatca gagttcttaa
     5221 caagattaat aaatcacctc agtcttaatt tgt
//