From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Nucleotide sequence of the cDNA insert of lambda PK129 coding for
Date: 29 Jul 92 10:03:01 GMT
Distribution: bionet
Checksum: 22716     5

LOCUS       HUMPPKKA     2267 bp ss-mRNA            PRI       29-JUL-1992
DEFINITION  Nucleotide sequence of the cDNA insert of lambda PK129 coding for
            human plasma prekallikrein.
ACCESSION   M13143
KEYWORDS    prekallikrein.
SOURCE      Human liver, cDNA to mRNA, clone lambda pK129.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Chung,D.W., Fujikawa,K., McMullen,B.A. and Davie,E.W.
  TITLE     Human plasma prekallikrein, a zymogen to a serine protease that
            contains four tandem repeats
  JOURNAL   Biochemistry 25, 2410-2417 (1986)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     CDS             94..2010
                     /note="plasma prekallikrein"
                     /gene="KLK3"
                     /codon_start=1
                     /translation="MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNA
                     QYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLK
                     QCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKA
                     EYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVAR
                     VLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTI
                     SGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYS
                     LLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIV
                     GGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSG
                     ILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG
                     DTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGY
                     KEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEK
                     TQSSDGKAQMQSPA"
BASE COUNT      677 a    474 c    517 g    599 t
ORIGIN
        1 ggtagtagca aatattcaaa tgagaacagc ttgaagaccg ttcattttta agtgacaaga
       61 gactcacctc caagaagcaa ttgtgttttc agaatgattt tattcaagca agcaacttat
      121 ttcatttcct tgtttgctac agtttcctgt ggatgtctga ctcaactcta tgaaaacgcc
      181 ttcttcagag gtggggatgt agcttccatg tacaccccaa atgcccaata ctgccagatg
      241 aggtgcacat tccacccaag gtgtttgcta ttcagttttc ttccagcaag ttcaatcaat
      301 gacatggaga aaaggtttgg ttgcttcttg aaagatagtg ttacaggaac cctgccaaaa
      361 gtacatcgaa caggtgcagt ttctggacat tccttgaagc aatgtggtca tcaaataagt
      421 gcttgccatc gagacattta taaaggagtt gatatgagag gagtcaattt taatgtgtct
      481 aaggttagca gtgttgaaga atgccaaaaa aggtgcacca ataacattcg ctgccagttt
      541 ttttcatatg ccacgcaaac atttcacaag gcagagtacc ggaacaattg cctattaaag
      601 tacagtcccg gaggaacacc taccgctata aaggtgctga gtaacgtgga atctggattc
      661 tcactgaagc cctgtgccct ttcagaaatt ggttgccaca tgaacatctt ccagcatctt
      721 gcgttctcag atgtggatgt tgccagggtt ctcactccag atgcttttgt gtgtcggacc
      781 atctgcacct atcaccccaa ctgcctcttc tttacattct atacaaatgt atggaaaatc
      841 gagtcacaaa gaaatgtttg tcttcttaaa acatctgaaa gtggcacacc aagttcctct
      901 actcctcaag aaaacaccat atctggatat agccttttaa cctgcaaaag aactttacct
      961 gaaccctgcc attctaaaat ttacccggga gttgactttg gaggagaaga attgaatgtg
     1021 acttttgtta aaggagtgaa tgtttgccaa gagacttgca caaagatgat tcgctgtcag
     1081 tttttcactt attctttact cccagaagac tgtaaggaag agaagtgtaa gtgtttctta
     1141 agattatcta tggatggttc tccaactagg attgcgtatg ggacacaagg gagctctggt
     1201 tactctttga gattgtgtaa cactggggac aactctgtct gcacaacaaa aacaagcaca
     1261 cgcattgttg gaggaacaaa ctcttcttgg ggagagtggc cctggcaggt gagcctgcag
     1321 gtgaagctga cagctcagag gcacctgtgt ggagggtcac tcataggaca ccagtgggtc
     1381 ctcactgctg cccactgctt tgatgggctt cccctgcagg atgtttggcg catctatagt
     1441 ggcattttaa atctgtcaga cattacaaaa gatacacctt tctcacaaat aaaagagatt
     1501 attattcacc aaaactataa agtctcagaa gggaatcatg atatcgcctt gataaaactc
     1561 caggctcctt tgaattacac tgaattccaa aaaccaatat gcctaccttc caaaggtgac
     1621 acaagcacaa tttataccaa ctgttgggta accggatggg gcttctcgaa ggagaaaggt
     1681 gaaatccaaa atattctaca aaaggtaaat attcctttgg taacaaatga agaatgccag
     1741 aaaagatatc aagattataa aataacccaa cggatggtct gtgctggcta taaagaaggg
     1801 ggaaaagatg cttgtaaggg agattcaggt ggtcccttag tttgcaaaca caacggaatg
     1861 tggcgtttgg tgggcatcac aagctggggt gaaggctgtg cccgcaggga gcaacctggt
     1921 gtctacacca aagtcgctga gtacatggac tggattttag agaaaacaca gagcagtgat
     1981 ggaaaagctc agatgcagtc accagcatga gaagcagtcc agagtctagg caatttttac
     2041 aacctgagtt caagtcaaat tctgagcctg gggggtcctc atctgcaaag catggagagt
     2101 ggcatcttct ttgcatccta aggacgaaag acacagtgca ctcagagctg ctgaggacaa
     2161 tgtctgctga agcccgcttt cagcacgccg taaccagggg ctgacaatgc gaggtcgcaa
     2221 ctgagatctc catgactgtg tgttgtgaaa taaaatggtg aaagatc
//