From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: M.musculus mRNA for son of sevenless 1
Date: 25 Jul 92 10:04:50 GMT
Distribution: bionet
Checksum: 19987    10

LOCUS       MUSSOS1G     4783 bp ss-RNA             ROD       25-JUL-1992
DEFINITION  M.musculus mRNA for son of sevenless 1
ACCESSION   Z11574
KEYWORDS    son of sevenless; son of sevenless 1.
SOURCE      Mus musculus RNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 4783)
  AUTHORS   Bowtell,D.D.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 4048)
  AUTHORS   Bowtell,D., Fu,P., Simon,M. and Senior,P.
  TITLE     Identification of murine homologues of the Drosophila son of
            sevenless gene: Potential activators of ras
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 6511-6515 (1992)
  STANDARD  full automatic
COMMENT     *source: strain=Random bred Swiss; *source: stage=Embryonic day 17
            Adult (brain); *source: tissue=eye adult brain; *source:
            clone_library=gt10 D. Bowtell unpublished RACE on adult *source:
            brain RNA; *source: clone=Composite RACE1/cDNA16.2/cDNA 2.1;
            *source: is_macronuclear=N; *source: is_proviral=N; *source:
            is_germline=N;
            From EMBL    entry MMSOS1G;  dated 05-MAY-1992.
FEATURES             Location/Qualifiers
     5'UTR           1..37
     CDS             38..4048
                     /function="putative guanine nucleotide exchangefactor"
                     /note="See entry for alternate aminoterminal end of mouse
                     Son of sevenless 1"
                     /product="mouse Son of sevenless 1"
                     /codon_start=1
                     /translation="MLVSHLILPRKQHPAGTMQAQQLPYEFFSEENAPKWRGLLVPAL
                     KKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKW
                     AIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGYKIDHQVSVYIVAVLEYISADILK
                     LVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTY
                     YDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSNDVENIFSRIVDIHELSVKL
                     LGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHGHFLSQLSK
                     PGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQ
                     AITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWE
                     GKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASSAEYRLK
                     EKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRST
                     LERMLDVTVLQEEKEEQMRLPSAEVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVL
                     KLIERLTYHMYADPNFVRTFLTTYRSFCRPQELLSLLIERFEIPEPEPTEADRIAIEN
                     GDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGTVRG
                     KAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHP
                     IEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCI
                     VETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ
                     KKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKEL
                     INFSKRRRVAEITGEIQQYQNQPYCLRVEPDIKRFFENLNPMGNSMEKEFTDYLFNKS
                     LEIEPRHPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPES
                     ETESTASAPNSPRTPLTPPPASGTSSNTDVCSVFDSDHSASPFHSRSASVSSISLSKG
                     TDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDR
                     TSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPP
                     PPQTPSPHGTRRHLPSPPLTQEMDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHP
                     SMHRDGPPLLENAHSS"
     3'UTR           4049..>4783
                     /note="Partial sequence. Polyadenylation siteapproximately
                     150bp further 3'"
BASE COUNT     1479 a   1072 c   1029 g   1203 t
ORIGIN
        1 gtgtgttcta gttgggtgca aggtctagcc taaggcaatg cttgtctccc acctcatcct
       61 gccaaggaag cagcaccccg cgggcaccat gcaggcgcag cagctgcctt acgagttttt
      121 cagcgaggag aacgcgccca agtggcgggg gctgctggtg cctgcgctga aaaaggttca
      181 ggggcaagtt caccctactc ttgagtctaa tgatgatgct cttcagtatg ttgaagaatt
      241 aattttgcaa ttactaaata tgctatgcca agctcagccc cggagtgctt cagatgtgga
      301 ggaacgtgtt caaaagagtt ttcctcatcc aattgataag tgggcaatag ctgatgccca
      361 atcagccatt gaaaagagga agagacgaaa tcctttatcg ctgccagcag aaagaattca
      421 tcatttatta agggaggtcc tcggttataa aattgaccac caggtttctg tttacatagt
      481 agcagtatta gaatacattt ctgcagatat tttaaagctc gtggggaatt atgtaagaaa
      541 tatacggcat tatgaaatta caaaacaaga cattaaagtg gcaatgtgtg ctgataaggt
      601 attgatggat atgtttcatc aagatgtaga agatataaat atcttatctt taactgatga
      661 agagccttcc acctcaggag aacaaactta ttatgatttg gtaaaagcat tcatggcaga
      721 aattcgacag tatataagag aattaaatct aattataaaa gtttttcgag agccctttgt
      781 ctctaattcc aaattgtttt catctaatga tgtagaaaac atattcagtc gtatagtaga
      841 tatacatgaa cttagtgtaa agttactggg ccatatagaa gatactgtag aaatgacaga
      901 tgaaggcagt ccccacccat tagtaggaag ctgttttgaa gacttagcag aagaactggc
      961 atttgacccg tatgagtcat atgctcggga tattttacga cccggattcc atggccattt
     1021 tcttagtcag ttatcaaagc ctggggcagc actttatttg cagtccatag gcgaaggctt
     1081 caaagaagct gtccagtacg tcctgccccg gctgctgctt gcccctgtgt accactgtct
     1141 gcattacttt gaacttctga agcagttaga agaaaagagt gaagatcaag aagacaagga
     1201 gtgtatgaag caagcaataa cagccctgct taatgtccaa agtggcatgg aaaaaatttg
     1261 ctccaaaagt cttgcaaaac gaagactaag tgagtctgca tgtcggtttt acagccagca
     1321 gatgaagggg aaacagctag ccatcaagaa gatgaacgag atccagaaga acattgatgg
     1381 ctgggagggg aaggacattg gacagtgttg caatgagttc ataatggaag gaactcttac
     1441 acgtgtagga gccaaacacg agagacacat atttctcttc gatggcttaa tgatttgctg
     1501 taaatcaaac catgggcagc caagactccc tggtgctagc agtgcagaat accggcttaa
     1561 agaaaagttt tttatgcgaa aggtacagat taatgataaa gatgacacca gtgagtacaa
     1621 gcatgctttt gaaatcattc tgaaagatgg caatagtgtt atattttctg ccaagtcagc
     1681 tgaagagaaa aacaactgga tggcagcact gatctctttg cagtaccgca gcaccctgga
     1741 gaggatgctg gacgtaacgg tgctgcagga ggagaaggag gagcagatga ggctgcccag
     1801 tgctgaagtg tacaggtttg cagaacctga ctccgaggag aatattctat tcgaagagaa
     1861 tgtgcagccc aaagctggga tccccattat caaggcaggg acagtgctta agctcattga
     1921 gaggcttacc taccacatgt acgcagatcc aaattttgtt cggacgtttc ttacaacata
     1981 caggtccttt tgcagacctc aagaactact gagtcttctg atagaaagat ttgaaattcc
     2041 agagcctgag ccaacagaag ctgatcgcat agctatagag aatggagatc agcccctgag
     2101 tgcagagctg aagaggttta gaaaggaata tattcagcct gtgcagttga gggtgttaaa
     2161 tgtgtgtcgg cactgggtgg agcaccattt ctatgacttt gaaagagatg cagacctttt
     2221 acagagaatg gaggaattta ttggaacagt aagaggtaaa gcaatgaaaa aatgggtcga
     2281 atccatcact aagataatcc aaaggaaaaa aattgcaaga gacaatggcc caggtcataa
     2341 cattacattt cagagctcac ctcccacagt tgagtggcac ataagcagac ctgggcacat
     2401 agagactttt gacttgctca ccttacaccc aatagaaatt gctcggcaac tcactttact
     2461 tgaatcagat ctataccggg ctgtgcagcc atcagaatta gttggaagtg tgtggacaaa
     2521 agaagataaa gaaattaatt ctcccaacct tctgaagatg attcggcaca ccactaacct
     2581 cactttgtgg tttgagaaat gtattgtaga aacagaaaac ttagaagaaa gagtagctgt
     2641 agtaagtcgg ataattgaga ttctacaagt ctttcaagag ctgaacaact tcaatggtgt
     2701 cctggaagtt gtcagtgcta tgaactcgtc acctgtttac agactagacc acacatttga
     2761 gcaaatacca agcagacaaa agaaaatttt agaagaagct catgaattga gtgaagatca
     2821 ctataagaaa tatttggcaa aactcaggtc tattaatcca ccgtgtgtgc ctttctttgg
     2881 aatttatctc acaaatatcc tgaagacaga agagggcaac cctgaggtcc tgaggagaca
     2941 cgggaaagag cttattaact tcagcaagag gaggagagtg gccgagatca caggcgagat
     3001 ccagcagtac cagaaccagc cctactgctt acgggtggag ccggacatca agaggttctt
     3061 tgaaaacttg aatccaatgg gaaacagcat ggagaaagaa tttacagact atctgttcaa
     3121 caaatcccta gaaatagaac cccggcaccc taagcctctt ccgagattcc caaaaaaata
     3181 cagctatccc ctaaaatctc ctggtgttcg tccatcaaat ccaagaccag gaaccatgag
     3241 acatcccaca cctctgcagc aggagccaag aaaaattagc tacagtcgga ttcctgaaag
     3301 tgagacggaa agcacagcat ctgcaccaaa ctcccctcgg accccactga cgccgccccc
     3361 tgcatctggc acctccagca acacagatgt ttgcagcgtg ttcgattctg accactcggc
     3421 aagccctttt cattcaagat ctgcttcagt ctcatctata agtttatcca agggcactga
     3481 tgaagtgcct gtcccccctc ctgtaccccc tcgaagacgt ccagagtctg ccccagctga
     3541 atcctcccca tccaagatta tgtctaagca cttggacagc cccccagcta ttcctcctag
     3601 gcaacccaca tccaaagcct attcaccacg ctattcaata tcagatcgga cctctatatc
     3661 agatcctcct gaaagccctc ccttgttacc accacgggaa cctgtgagga cacctgatgt
     3721 tttctcaagc tcaccattac atctccaacc tcctcctttg ggcaaaaaga gtgatcatgg
     3781 caacgccttc ttcccaaaca gcccatcccc ttttacaccg ccaccccccc aaaccccctc
     3841 tcctcatggc acgagaaggc atctgccatc accaccactg acacaggaga tggacctcca
     3901 ttccattgct gggcctcctg ttcctccacg acaaagcact tctcaactta tccccaaact
     3961 ccctccaaaa acttacaaaa gggagcacac acacccatcc atgcatagag atggaccacc
     4021 actgctggag aatgcccatt cttcctgagt tcctctaagc tgggatagtt tcctagcccc
     4081 cagatccatt gctggcaatg gatgcactga acatgccagc actggggagt tcaaatgaga
     4141 actccaaaca ctaacgactc tacttcacga tgtagtataa gacaatgagt tttaacctac
     4201 atggaattat ggaataaaat ggtattccag cttagaatgt ggaaactgat tgcacctgga
     4261 aatcacgtga agggactttt ctggccattg ggcagagtcc tcatattgtg aagtgatctt
     4321 tatcattaaa gggatggaaa acagtctaat gtccaacaag cccatatgtt gacagttttt
     4381 gtaattcaaa atattatgca cttttaaaaa atcttaaaca gggatctcct cctttgtttt
     4441 cctttgcttt actcttctac tttagaatat tttcgtaaaa gttattcaga ggactgtgag
     4501 aaaaggctgt ggtacctgac cttgttgaaa tcaaggccca gcactgtact acagtcctgt
     4561 ttacagatta ttacagtgat ctgaatgggt accgaggctt caccaaaaga ggtacttttt
     4621 gttattgtta ttgtttaaga ataattatgc caatttaaga acatccccta cccaccccca
     4681 ctcacaaaca aaatgtggtg gtgttgcctt taaacaaaaa atgtcaatgt cattaacatg
     4741 atggaagaag aacattttaa aacgtaactg tcaagtatca ttt
//