From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mRNA for B-lymphocyte CR2-receptor (for complement factor C3d
Date: 5 Nov 92 23:09:21 GMT
Distribution: bionet
Checksum: 21420 9

LOCUS       HUMBLCR2     3923 bp ss-RNA             PRI       15-MAY-1992
DEFINITION  Human mRNA for B-lymphocyte CR2-receptor (for complement factor C3d
            and Epstein-Barr virus)
ACCESSION   Y00649
KEYWORDS    C3d complement component receptor; CR2 complement receptor type 2.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Weis,J.J., Toothaker,L.E., Smith,J.A., Weis,J.H. and Fearon,D.T.
  TITLE     Structure of the human B lymphocyte receptor for C3d and the
            Epstein-Barr virus and relatedness to other members of the family
            of C3/C4 binding proteins
  JOURNAL   J. Exp. Med. 167, 1047-1066 (1988)
  STANDARD  full automatic
COMMENT     *source: tissue=B-lymphocytes of tonsils; *source: chromosome=
            chromosome 1, q32;

            177 nucleotide insertion that was found in one out of five CR2 cDNA
            clones and that maintained the open reading frame of the other
            clones (inserted at pos. 2030-2031)  ggctgccagc cacctcctgg
            gctccaccat ggtcatcata caggtggaaa tacggtcttc tttgtctctg ggatgactgt
            agactacact tgtgaccctg gctatttgct tgtgggaaac aaatccattc actgtatgcc
            ttcaggaaat tggagtcctt ctgccccacg gtgtgaa
               From EMBL    entry HSBLCR2;  dated 15-MAY-1992.
FEATURES             Location/Qualifiers
     sig_peptide     56..115
                     /note="signal peptide (AA -20 to -1)"
                     /codon_start=1
     mat_peptide     116..3148
                     /note="mature CR2 receptor (AA 1 - 1031)"
                     /codon_start=1
     misc_feature    2030..2031
                     /note="insertion site of a 177 nt insertfound in one of of
                     five cDNAclones (see CC)"
     misc_feature    2978..3049
                     /note="transmembrane region"
     misc_feature    3896..3901
                     /note="polyA signal"
     CDS             56..3154
                     /note="(AA -1 to 1031)"
                     /note="CR2 receptor precursor"
                     /codon_start=1
                     /translation="MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVG
                     TVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKI
                     RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMI
                     HNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSL
                     GRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFC
                     PSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGT
                     WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR
                     CNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES
                     IQCTSEVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC
                     QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFS
                     LIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDT
                     VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNT
                     SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG
                     NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKL
                     NKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKT
                     PNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP
                     ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSL
                     APVLCGIAAGLILLTFLIVVTLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNP
                     AS"
BASE COUNT     1071 a    874 c    886 g   1092 t
ORIGIN      
        1 cccggacgct cgcgggtctc ggaacgcatc ccgccgcggg ggcttcggcc gtggcatggg
       61 cgccgcgggc ctgctcgggg ttttcttggc tctcgtcgca ccgggggtcc tcgggatttc
      121 ttgtggctct cctccgccta tcctaaatgg ccggattagt tattattcta cccccattgc
      181 tgttggtacc gtgataaggt acagttgttc aggtaccttc cgcctcattg gagaaaaaag
      241 tctattatgc ataactaaag acaaagtgga tggaacctgg gataaacctg ctcctaaatg
      301 tgaatatttc aataaatatt cttcttgccc tgagcccata gtaccaggag gatacaaaat
      361 tagaggctct acaccctaca gacatggtga ttctgtgaca tttgcctgta aaaccaactt
      421 ctccatgaac ggaaacaagt ctgtttggtg tcaagcaaat aatatgtggg ggccgacacg
      481 actaccaacc tgtgtaagtg ttttccctct cgagtgtcca gcacttccta tgatccacaa
      541 tggacatcac acaagtgaga atgttggctc cattgctcca ggattgtctg tgacttacag
      601 ctgtgaatct ggttacttgc ttgttggaga aaagatcatt aactgtttgt cttcgggaaa
      661 atggagtgct gtccccccca catgtgaaga ggcacgctgt aaatctctag gacgatttcc
      721 caatgggaag gtaaaggagc ctccaattct ccgggttggt gtaactgcaa actttttctg
      781 tgatgaaggg tatcgactgc aaggcccacc ttctagtcgg tgtgtaattg ctggacaggg
      841 agttgcttgg accaaaatgc cagtatgtga agaaattttt tgcccatcac ctccccctat
      901 tctcaatgga agacatatag gcaactcact agcaaatgtc tcatatggaa gcatagtcac
      961 ttacacttgt gacccggacc cagaggaagg agtgaacttc atccttattg gagagagcac
     1021 tctccgttgt acagttgata gtcagaagac tgggacctgg agtggccctg ccccacgctg
     1081 tgaactttct acttctgcgg ttcagtgtcc acatccccag atcctaagag gccgaatggt
     1141 atctgggcag aaagatcgat atacctataa cgacactgtg atatttgctt gcatgtttgg
     1201 cttcaccttg aagggcagca agcaaatccg atgcaatgcc caaggcacat gggagccatc
     1261 tgcaccagtc tgtgaaaagg aatgccaggc ccctcctaac atcctcaatg ggcaaaagga
     1321 agatagacac atggtccgct ttgaccctgg aacatctata aaatatagct gtaaccctgg
     1381 ctatgtgctg gtgggagaag aatccataca gtgtacctct gaggtgtgga caccccctgt
     1441 accccaatgc aaagtggcag cgtgtgaagc tacaggaagg caactcttga caaaacccca
     1501 gcaccaattt gttagaccag atgtcaactc ttcttgtggt gaagggtaca agttaagtgg
     1561 gagtgtttat caggagtgtc aaggcacaat tccttggttt atggagattc gtctttgtaa
     1621 agaaatcacc tgcccaccac cccctgttat ctacaatggg gcacacaccg ggagttcctt
     1681 agaagatttt ccatatggaa ccacggtcac ttacacatgt aaccctgggc cagaaagagg
     1741 agtggaattc agcctcattg gagagagcac catccgttgt acaagcaatg atcaagaaag
     1801 aggcacctgg agtggccctg ctcccctgtg taaactttcc ctccttgctg tccagtgctc
     1861 acatgtccat attgcaaatg gatacaagat atctggcaag gaagccccat atttctacaa
     1921 tgacactgtg acattcaagt gttatagtgg atttactttg aagggcagta gtcagattcg
     1981 ttgcaaagct gataacacct gggatcctga aataccagtt tgtgaaaaag aaacatgcca
     2041 gcatgtgaga cagagtcttc aagaacttcc agctggttca cgtgtggagc tagttaatac
     2101 gtcctgccaa gatgggtacc agttgactgg acatgcttat cagatgtgtc aagatgctga
     2161 aaatggaatt tggttcaaaa agattccact ttgtaaagtt attcactgtc accctccacc
     2221 agtgattgtc aatgggaagc acacaggcat gatggcagaa aactttctat atggaaatga
     2281 agtctcttat gaatgtgacc aaggattcta tctcctggga gagaaaaaat tgcagtgcag
     2341 aagtgattct aaaggacatg gatcttggag cgggccttcc ccacagtgct tacgatctcc
     2401 tcctgtgact cgctgcccta atccagaagt caaacatggg tacaagctca ataaaacaca
     2461 ttctgcatat tcccacaatg acatagtgta tgttgactgc aatcctggct tcatcatgaa
     2521 tggtagtcgc gtgattaggt gtcatactga taacacatgg gtgccaggtg tgccaacttg
     2581 tatcaaaaaa gccttcatag ggtgtccacc tccgcctaag acccctaacg ggaaccatac
     2641 tggtggaaac atagctcgat tttctcctgg aatgtcaatc ctgtacagct gtgaccaagg
     2701 ctacctgctg gtgggagagg cactccttct ttgcacacat gagggaacct ggagccaacc
     2761 tgcccctcat tgtaaagagg taaactgtag ctcaccagca gatatggatg gaatccagaa
     2821 agggctggaa ccaaggaaaa tgtatcagta tggagctgtt gtaactctgg agtgtgaaga
     2881 tgggtatatg ctggaaggca gtccccagag ccagtgccaa tcggatcacc aatggaaccc
     2941 tcccctggcg gtttgcagat cccgttcact tgctcctgtc ctttgtggta ttgctgcagg
     3001 tttgatactt cttaccttct tgattgtcgt taccttatac gtgatatcaa aacacagagc
     3061 acgcaattat tatacagata caagccagaa agaagctttt catttagaag cacgagaagt
     3121 atattctgtt gatccataca acccagccag ctgatcagaa gacaaactgg tgtgtgcctc
     3181 attgcttgga attcagcgga atattgatta gaaagaaact gctctaatat cagcaagtct
     3241 ctttatatgg cctcaagatc aatgaaatga tgtcataagc gatcacttcc tatatgcact
     3301 tattctcaag aagaacatct ttatggtaaa gatgggagcc cagtttcact gccatatact
     3361 cttcaaggac tttctgaagc ctcacttatg agatgcctga agccaggcca tggctataaa
     3421 caattacatg gctctaaaaa gttttgccct ttttaaggaa ggcactaaaa agagctgtcc
     3481 tggtatctag acccatcttc tttttgaaat cagcatactc aatgttacta tctgcttttg
     3541 gttataatgt gtttttaatt atctaaagta tgaagcattt tctggggtta tgatggcctt
     3601 acctttatta ggaagtatgg ttttattttg atagtagctt cctcctctgg ttggtgttaa
     3661 tcatttcatt tttaccctta cttggtttga gtttctctac attactgtat atactttgcc
     3721 tttccataat cactcagtga ttgcaatttg cacaagtttt tttaaattat gggaatcaag
     3781 atttaatcct agagatttgg tgtacaattc aggctttgga tgtttcttta gcagttttgt
     3841 gataagttct agttgcttgt aaaatttcac ttaataatgt gtacattagt cattcaataa
     3901 attgtaattg taaagaaaac aaa
//