From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human excision repair protein ERCC6 mRNA, complete cds.
Date: 3 Jan 93 22:06:25 GMT
Distribution: bionet
Checksum: 56061 10

LOCUS       HUMERCC6A    4714 bp ss-mRNA            PRI       21-DEC-1992
DEFINITION  Human excision repair protein ERCC6 mRNA, complete cds.
ACCESSION   L04791
KEYWORDS    active gene repair; helicase.
SOURCE      Homo sapiens testis, placenta mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4714)
  AUTHORS   Troelstra,C., Van Gool,A., de Wit,J., Vermeulen,W., Bootsma,D. and
            Hoeijmakers,J.H.
  TITLE     ERCC6, a member of a subfamily of putative helicases, is involved
            in cockayne's syndrome and preferential repair of active genes
  JOURNAL   Cell (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     misc_signal     1475..1522
                     /standard_name="bipartite nuclear location signal"
                     /gene="ERCC6"
                     /note="putative"
     misc_signal     3191..3244
                     /standard_name="bipartite nuclear location signal"
                     /gene="ERCC6"
                     /note="putative"
     CDS             80..4561
                     /standard_name="excision repair cross complementing rodent
                     repair deficiency, complementation group 6"
                     /gene="ERCC6"
                     /note="putative casein kinase II phosphorylation site bp
                     1526..1549 and 3281..3301; putative helicase domains I-VI
                     bp 1658..2929; putative nucleotide binding fold bp
                     3479..3493; homology to helicase subfamily bp 1658..3100"
                     /product="excision repair protein"
                     /codon_start=1
                     /translation="MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEY
                     LSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQ
                     DVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQ
                     AATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAE
                     PGPSSLGSMLMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLA
                     DQAKLSFERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKK
                     LQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAE
                     ADLSGDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVG
                     RYRDDGDEDYYKQRLRRWNKLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLF
                     KYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGL
                     GPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITS
                     YSYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNL
                     RELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINP
                     YLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRILNGEMQIFSG
                     LIALRKICNHPDLFSGGPKNLKGLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQ
                     RVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTT
                     RVGGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKI
                     YHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQSTETSAIFAGTGSDVQ
                     TPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEAKGAEVNAVTSNRS
                     DPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSMPSGDES
                     IDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQ
                     KPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGV
                     HSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGI
                     SGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDAD
                     SSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIA
                     FQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC"
BASE COUNT     1433 a    993 c   1220 g   1068 t
ORIGIN      
        1 tgggttccaa ggcggctggc ggcggtagcg tctctgtttc cttgtgggcg ctcgcgcggc
       61 cctgggtagt ctgtagagaa tgccaaatga gggaatcccc cactcaagtc aaactcagga
      121 gcaagactgt ttacagagtc aacctgtcag taataatgaa gaaatggcaa tcaagcaaga
      181 aagtggtggt gatggggagg tggaggagta cctgtccttt cgttctgtgg gtgacgggct
      241 gtccacctct gctgtggggt gcgcatcagc agctccgagg agagggccag ccctgctgca
      301 catcgaccga catcagatcc aggcagtaga gcctagcgcc caggcccttg agctgcaggg
      361 tttgggtgtg gacgtctatg accaggacgt gctggaacag ggagtgcttc agcaggtgga
      421 caatgccatc catgaggcca gccgtgcctc ccagctcgtt gacgtggaga aggagtatcg
      481 gtcggtcctg gatgacctca cgtcatgtac gacatcccta aggcaaatca ataaaattat
      541 tgaacagctt agccctcaag ctgccaccag cagagacatc aacaggaaac tagattctgt
      601 aaaacgacag aagtataata aggaacaaca gctaaaaaag atcactgcaa aacaaaagca
      661 tctccaggcc atccttggag gagcagaggt gaaaattgaa ctagatcacg ccagtctgga
      721 ggaggatgca gagccggggc catccagtct tggcagcatg ctcatgcctg tccaggagac
      781 tgcctgggaa gagctcatcc gcactggcca gatgacacct tttggtaccc agatccctca
      841 gaaacaggag aaaaagccca gaaaaatcat gcttaatgaa gcatcaggct tcgaaaagta
      901 tttggcagat caagcaaaac tgtcttttga aaggaagaag caaggttgta ataaaagagc
      961 agctagaaaa gctccagccc cagtcacgcc tccagcccca gtgcaaaata aaaacaaacc
     1021 aaacaagaaa gccagagttc tgtccaaaaa agaggagcgt ttgaaaaagc acatcaagaa
     1081 actccagaag agggctttgc agttccaggg gaaagtggga ttgccaaagg caaggagacc
     1141 ttgggagtca gacatgaggc cagaggcaga gggagactct gagggtgaag agtctgagta
     1201 tttccccaca gaggaggagg aagaggagga agatgacgag gtggaggggg cagaggcgga
     1261 cctgtctgga gatggtactg actatgagct gaagcctctg cccaagggcg ggaaacggca
     1321 gaagaaagtg ccagtgcagg agattgatga tgactttttc ccaagttctg gggaagaagc
     1381 tgaagctgct tctgtaggag aaggaggagg aggaggtcgg aaagtgggaa gataccgaga
     1441 tgatggagat gaagattatt ataagcagcg gttaaggaga tggaataaac tgagactgca
     1501 ggacaaagag aaacgtctga agctggagga cgattctgag gaaagtgatg ctgaatttga
     1561 cgaaggtttt aaagtgccag gttttctgtt caaaaagctt tttaagtacc agcagacagg
     1621 tgttaggtgg ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagatgaaat
     1681 gggattgggc aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat
     1741 caggactcgt ggttcaaatt acaggtttga ggggttgggt ccaactgtaa ttgtctgtcc
     1801 aacaacagtg atgcatcagt gggtgaagga atttcacacg tggtggcctc cgttcagagt
     1861 ggcaattcta catgaaaccg gttcctatac ccacaaaaag gagaaactaa ttcgagatgt
     1921 tgctcattgt catggaattt tgatcacatc ttactcctac attcgattga tgcaggatga
     1981 cattagcagg tatgactggc actatgtgat cttggacgaa ggacacaaaa ttcgaaatcc
     2041 aaatgctgct gtcacccttg cttgcaaaca gtttcgcacc cctcatcgga tcattctgtc
     2101 tggctcaccg atgcaaaata acctccgaga gctgtggtcg ctctttgact tcatcttccc
     2161 gggaaagtta ggcacgttgc ctgtgtttat ggagcagttc tccgtcccca tcaccatggg
     2221 gggatattca aatgcttccc cagtacaggt caaaactgct tacaagtgtg catgtgtctt
     2281 acgagatacc ataaatccat acctactgcg gagaatgaag tcagatgtca agatgagcct
     2341 ttctttgcca gataaaaatg aacaggtctt attttgccgt cttacagatg agcagcataa
     2401 agtctaccaa aatttcgttg attccaaaga agtttacagg attctcaatg gagagatgca
     2461 gattttctcc ggacttatag ccctaagaaa aatttgcaac caccctgatc tcttttctgg
     2521 aggtcccaag aatctcaaag gtcttcctga tgatgaacta gaagaagatc agtttgggta
     2581 ctggaaacgt tctgggaaaa tgattgttgt tgagtctttg ttgaaaatat ggcacaagca
     2641 gggtcagcga gtattgctgt tttctcagtc aaggcagatg ctggacatac ttgaagtatt
     2701 ccttagagcc caaaagtata cctatctcaa gatggatggt accactacaa tagcttcaag
     2761 acagccactg attacgagat acaatgagga cacatccata tttgtgtttc ttctgaccac
     2821 gcgggtgggc ggcttaggtg tcaacctgac gggggcaaac agagttgtca tctatgaccc
     2881 agactggaac ccaagcacgg acacgcaggc ccgggagcga gcatggagaa taggccagaa
     2941 gaagcaagtg actgtgtaca ggctcctgac tgcgggcacc attgaagaaa agatctacca
     3001 ccgacaaatc ttcaagcagt ttttgacaaa tagagtgcta aaagacccaa aacaaaggcg
     3061 gtttttcaaa tccaatgatc tctatgagct atttactctg actagtcctg atgcatccca
     3121 gagcactgaa acaagtgcaa tttttgcagg aactggatca gatgttcaga cacccaaatg
     3181 ccatctaaaa agaaggattc aaccagcctt tggagcagac catgatgttc caaaacgcaa
     3241 gaagttccct gcttctaaca tatctgtaaa tgatgccaca tcatctgaag agaaatctga
     3301 ggctaaagga gctgaagtaa atgcagtaac ttctaatcga agtgatcctt tgaaagatga
     3361 ccctcacatg agtagtaatg taactagcaa tgataggctt ggagaagaga caaatgcagt
     3421 atctggacca gaagagttgt cagtgattag tggaaatggg gaatgttcaa attcttcagg
     3481 aacaggcaaa acttctatgc catctggtga tgaaagcatt gatgaaaagt taggtctttc
     3541 ttacaaaaga gaaagaccca gccaggctca aacagaagct ttttgggaga ataaacaaat
     3601 ggaaaataat ttttataagc acaagtcaaa aacaaaacat catagtgtgg cagaagaaga
     3661 gaccctggag aaacatctga gaccaaagca aaagcctaag aactctaagc attgcagaga
     3721 cgccaagttt gaaggaactc gaattccaca cctggtgaag aaaaggcgtt accagaagca
     3781 agacagtgaa aacaagagtg aggccaagga acagagcaat gacgattatg ttttggaaaa
     3841 gcttttcaaa aaatcagttg gcgtgcacag tgtcatgaag cacgatgcca tcatggatgg
     3901 agccagccca gattatgtac tggtggaggc agaagccaac cgagtggccc aggatgccct
     3961 gaaagcactg aggctctctc gtcagcggtg tctgggagca gtgtctggtg ttcccacctg
     4021 gactggccac agggggattt ctggtgcacc agcaggaaaa aagagtagat ttggtaagaa
     4081 aaggaattct aacttctctg tgcagcatcc ttcatcaaca tctccaacag agaagtgcca
     4141 ggatggcatc atgaaaaagg agggaaaaga taatgtccct gagcatttta gtggaagagc
     4201 agaagatgca gactcttcat ccgggcccct cgcttcctcc tcactcttgg ctaaaatgag
     4261 agctagaaac cacctgattc tgccagagcg tttagaaagt gaaagcgggc acctgcagga
     4321 agcttctgcc ctgctgccca ccacagaaca cgatgacctt ctggtggaga tgagaaactt
     4381 catcgctttc caggcccaca ctgatggcca ggccagcacc agggagatac tgcaggagtt
     4441 tgaatccaag ttatctgcat cacagtcttg tgtcttccga gaactattga gaaatctgtg
     4501 cactttccat agaacttctg gtggtgaagg aatttggaaa ctcaagccag aatactgcta
     4561 aacaacattg cttcctaaac tttcaagtcc ctttttctaa cgggcatttc tgattattaa
     4621 tttattatta ataatcatgt ttgtcaatgg aagttggctg cacttgatgt ttgtttgcat
     4681 gatgtctacc tcagaattaa aactttaagg aagg
//