From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human herpesvirus-6 genes encoding Rep protein homologue and US22
Date: 12 Sep 92 10:02:21 GMT
Distribution: bionet
Checksum: 11356    22

LOCUS       HH6HCLF     12051 bp ds-DNA             VRL       12-SEP-1992
DEFINITION  Human herpesvirus-6 genes encoding Rep protein homologue and US22
            gene family product homologue.
ACCESSION   D11134
KEYWORDS    KpnI repetitive sequence; Rep protein homologue;
            US22 gene family homologue.
SOURCE      Human herpesvirus type 6 (strain U1102) DNA.
  ORGANISM  Human herpesvirus 6
            Viridae; ds-DNA enveloped viruses; Herpesviridae;
            Betaherpesvirinae.
REFERENCE   1  (bases 1 to 12051)
  AUTHORS   Thomson,B.J. and Honess,R.W.
  TITLE     The right end of the unique region of the genome of human
            herpesvirus-6 (HHV-6) U1102 contains a candidate immediate early
            gene enhancer and a homologue of the human cytomegalovirus US22
            gene family
  JOURNAL   J. Gen. Virol. (1992) In press
  STANDARD  full staff_review
COMMENT     These data kindly submitted in computer readable form by:
            Brian J. Thomson
            Level 5, Addenbrooke's Hospital
            Department of Medicine
            University of Cambridge
            Cambridge CB2 2QQ
            U. K.
            Phone: 0223-336860
            Fax: 0223-336846
FEATURES             Location/Qualifiers
     CDS             complement(<1..182)
                     /note="5' end uncertain"
                     /gene="HCLF4"
                     /codon_start=1
                     /translation="SLLDLSYLRLFGNFSKYLKNIYTYSYRPDPMMEESIKEILEESL
                     MCDTSFDDLIIPGLES"
     TATA_signal     complement(118..123)
     CDS             complement(337..717)
                     /partial
                     /gene="HCLF3"
                     /codon_start=1
                     /translation="KQTIRDIFFFILKECMQIYNQYIKIKKTYPSLTRSSGFSAVGSR
                     CAYMLQRRSHTSESSLEYLWPDIISSISKNIVAIRNINSRHASIFRLVFPVPVDDFFP
                     IMVSVTDVQAENLCKERGGGNVLI"
                     /partial
     CDS             628..972
                     /note="5' end uncertain"
                     /gene="HCRF1"
                     /codon_start=1
                     /translation="RICLFYFNVLIIYLHTFLKNEKKNITDGLFLDSVTSQAMENKES
                     MKKNEGEPPVWIQALTTTLSIILLVCIIMACIICSRTTEEEKSEMQSSASSVETLQSL
                     NEAIFPKGEMNV"
                     /partial
     TATA_signal     660..665
     repeat_region   2009..5094
                     /note="All but two of these contain a binding site for the
                     NF-kB family of transcription factors and 17 contain
                     consensus AP2 binding site. The 'KpnI repeats' may
                     therefore constitute an enhancer element."
     CDS             complement(5537..7123)
                     /note="5' end uncertain"
                     /product="Rep protein homologue"
                     /gene="HCLF2"
                     /codon_start=1
                     /translation="EFVAKTNRPDVQTSRGDKPGELPYFPYTTIKNLGGANGMFSIIN
                     PSDDFWTKDKYIMLTIKGPMEWEAEIPGISTDFFCKFSNVSVPHFRDMHSPGAPDIKW
                     ITACTKMIDVILNYWNNKTAVPTPAKWYAQAENKAGRPSLILLIALDGIPSATIGKHT
                     TEIRGVLIKDFFDGNAPKIDDWCTYAKTKKNGGGTQVFSLSYIPFALLQIIRPQFQWA
                     WTNINELGDVCDEIHRKHIISHFNKKPNVKLMLFPKDGINGISLKSKFLGTIEWLSDL
                     GIVTEDAWIRRDIRSYMQLLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTDFQ
                     IYENPVYQLFCLQSFDPILAGTILYQWLSHRGGKKNTVSFIGPPGCGKSMLTGAILEN
                     IPLHGILHGSLNTKNLRAYGQVLVLWWKDISINFDNFNIIKSLLGGQKIIFPINENDH
                     VQIGPCPIIATSCVDIRSMVHSNLHKINLSQRVYNFTFDKVIPRNFPVIQKDDINQFL
                     FWARNRSINCFIDYTVPKIL"
                     /partial
     TATA_signal     6995..7000
     TATA_signal     complement(7032..7037)
     CDS             7084..10449
                     /note="US22 gene family homologue"
                     /gene="HCRF2"
                     /codon_start=1
                     /translation="MSAHPDDLFWQQILNMDPTELLSDDVISSTCDENTAAGTDIMQP
                     LCVDMSVQPTTSGCHTGAMMSDSYFSNDTPDQNCQSHSTLTDLSPEDMNNQINVQPNQ
                     MTFQPISPPIQDQNYGYSNNMINPIKPASIIKLHGHSIGEMTVTDPSSHVNAQHFVQQ
                     SNPKFFLNMYPCMTANSQGPGECQSVHNQSSGSGSNSYDINTAPRDEWIFTTSGGESW
                     VLKRNTPNPPNSRTNLIFNNAQPIFHTQPQVSGFSDCSYQGGGLNSREYVNLAGYTPV
                     CNMQNIKNSWATQLGASIDCMTASPTGIDANVNSAFQPVGVVSNNRGANVSMGGMGNY
                     IENNSPWNQYYKSEMANNSINVKESNVYGHVGCVNDAISDKQGGTANVPSSLLNPDHQ
                     DWMRMTGTNTHMLNNINTNTEMENYDFPENDGNVHGATGVDLSTLSNGQQHSAFEGNG
                     TFPVVNTGNPRTTLNCAPQLFLLGGNPTIAHPMNGNNETPDKNVCKPTPSTGVIKKLN
                     FDGVDRGGGIGNFPKLASFVAMREKMSNTVNPSCGTFLEQLEGLRQQNSFEKNISFAD
                     LHFSEEDDVLSSASSVSCNSNCDMKIEVSQQGITVSNLQQGFRQQMNMNSSVVKMDGS
                     YKTQEMSNGCATDVTDNAGTIQQNKRIHSQNENPEDGQVREGGCSDVRNEPPRKSARI
                     HNMKSEGVTCGMCMTAADSTRQDASGGSSSGTKNEYYDDESELTGLSDTDSDNEVQCC
                     QEVTKVGPKTYSSENFNPEYRQAKRLLADIPYRRWIPDPVNMEDNDGPFIPIVTRPAT
                     VCMNGRRRRTFFRQCVTAFGPLSKLTYFKELLQSYVSKNNNSYLSISWPPKHGVYVMS
                     EKKLGYEHIPTLKDKFPLPCGWMMVLGVVGAEPPAALNKNMVILLCENRWVLLHNYSN
                     STHELFLAASDLKQFMEEGLSRCDPIYEESTVPYGVAMENSLRDFLRNSRTFQDLMDQ
                     RDNMHGCNWTFNGMPGRLGDRVIHLCNPESVDSIPGDEAVVCEGRPLYFFAYVTTFKS
                     NPATKATVLIAADKDLRIYGYHKGRPRIRYLCKNVKTFFKAGARKFYLDFQITPKRLL
                     AVNEEEYLNTLQNAPCLLLKPSVFRNIYSQEGK"
     CDS             complement(10784..11179)
                     /note="5' end uncertain"
                     /gene="HCLF1"
                     /codon_start=1
                     /translation="IAGRPTITFHVFFVFFLSDYGRDVINNLTKSAMLARKNGPRYLQ
                     MENGPRYLQMETFISDLFRHECYQDNYYVLDKKLQMFYPTTHSNELLFYPSEATLPSP
                     WQEPPFSSPWPEPTFPSRWYWLLLNYTNY"
                     /partial
     TATA_signal     complement(11179..11184)
     TATA_signal     11749..11754
     CDS             11754..12023
                     /note="5' end uncertain"
                     /gene="HCRF3"
                     /codon_start=1
                     /translation="YEYLQLYIQFNIHMVDNALFIYSKKQQKLSGVIFIYIDKVYKCI
                     CKHNRKIYMSQGVYILTRAHNGQVLTTVGFIFIILMFSDFTSFGL"
                     /partial
BASE COUNT     3555 a   2540 c   2508 g   3448 t
ORIGIN      Map position approximately nucleotides 138,000 to 150,000.
        1 aagctttcaa ggcctggaat aatcaggtca tcgaaggatg tatcacacat gagactctct
       61 tccaatattt ctttgataga ttcttccatc attggatcgg gacggtagct gtaagtataa
      121 atatttttta agtacttaga aaaattccca aataatctta aataagatag atctaataat
      181 gactaatcat acttactctt gcatacgttc atcattggat cccatgttgt ttccagaggg
      241 ttttgctggc tccattgtat attaagatgc aaattgagac accgcctact gtgctgatag
      301 ccaatgaaaa aatatctccc gtcagcacat ataatactat ataaggacat taccaccacc
      361 tctttctttg cagagattct ctgcttgcac atctgtaaca ctgaccataa tggggaaaaa
      421 atcatctact ggaactggaa aaactaatct aaagatactg gcatgtctac tattgatatt
      481 tctaatggca acaatatttt tgctaatact ggaaattata tcgggccaaa gatattccaa
      541 tgatgattcc gaagtgtgac tgcggcgctg aagcatgtaa gcacacctac taccaactgc
      601 actgaaacca ctactcctgg ttagtgaagg atatgtcttt tttattttaa tgtattgatt
      661 atatatttgc atacattcct taagaatgaa aaaaaaaata tcacggatgg tttgttttta
      721 gattccgtaa cgagccaagc catggaaaac aaagaatcaa tgaaaaaaaa tgaaggggaa
      781 cctccagttt ggattcaggc tttaactaca acattatcaa ttatcctatt ggtttgcata
      841 ataatggcat gcattatatg ttcccggacc acggaagaag agaagagcga aatgcaatct
      901 tctgcttctt cagtagagac tttacagtct ttaaatgagg ctatttttcc gaaaggtgaa
      961 atgaatgtgt aatgtctgta tttttctttg cagagatgta tggagagctt atattggggg
     1021 aaaatacctg actgttctgc ctatattcga atgttgaagt atgtacaata taatttctta
     1081 ccttttaaga gtgattcaag gtggaggttt ctttggagat gattccaagt ggtggttttg
     1141 ggcgcaatca atcttctggg tgggaagaaa atccagcaat gtaataattg atgggatgca
     1201 atcgatgtga caaatctgta agattaaatg tgaacattat aaattatttt gtgattaaca
     1261 aattacaatc atgtgcatga aaatatcatt aaattgtttt acaaatttta aatgcaattt
     1321 aaaagaattt ttgtagcaat cttaaatatt aatcgttaca aaattgactt accagactgc
     1381 aacgatataa gaaagaatgt ctgtgatgag aatgttctcc ggagccactt cttgagaata
     1441 gtggcactga actggctgta acttctgctt atatacaatt ctgtagcggg tgtgatgtac
     1501 aggaaaatga cgaagatgaa ggaaccaatc gctgcataac gttaaaccgc aagtgcagaa
     1561 atacacccct tttagacaaa tatggaattg aaattagtta atgcttgcaa aaatttaggg
     1621 ttttgttata ttttacaaaa acaggaattt gtggtctgga ttttttgagg ttttttataa
     1681 taaacaacat tttactgata aattgtcatg ttttttctaa gaacatctgt tacacatcat
     1741 aagacatgtg gttttggtgt tagcgtttct caataaataa atgactcagt cagaggaaaa
     1801 tgttgcaatc gcggtcccca ctaaccttta attttatgag aaaaacagga actgcggttg
     1861 ccccgttagc aaattttagg gttcttgtta gcttgggcag gaaagacccc aaccgcgata
     1921 cccactgacc tttaattttc cgagaaaaac aggaactgcg gttgccgcgt tacgagattt
     1981 tagagttctc gtttgcctgg gcaggaaata ttttccgaga aaaacaggaa ctgcggttgc
     2041 cgcgttacga gatgttagag ttctcgttcg cctgggcagg aaacacctca accgcggtac
     2101 ccactgacct ttatttttct gagaagaaca ggaactgcgg ttgccgcgtt agcagatgtt
     2161 agagttctcg ttcgcctggg taggaaacac ctcaaccgcg gtacccactg acctttaatt
     2221 ttccgagaaa aacagaaact gcggttgccg cgttagcagc ttttagagtt ctcgttcgcc
     2281 tgtgcaggaa agaccccaac cgcggtaccc actgatcttt atctttatga agaaaaacag
     2341 gaactgcggt tgccgcgtta gcagctttta gagttctcgt tcgcctgtgc aggaaagacc
     2401 ccaaaccgcg gtacccactg acttttagtt ttccgagaaa aacagaaact gcggttgccg
     2461 cgttagcagc ttttagagtt ttcgttcgcc tgtgcaggaa agaccccaaa ccgcggtacc
     2521 cactgacttt taattttccg agaaaaacag aaactgcggt tgccgcgtta gcagctttta
     2581 gagttctcgt tcgcctgtgc aggaaagacc cccaaaccgc ggtacccact gacttttaat
     2641 tttccgagaa aaacagaaac tgcggttgcc gcgttagcag cttttagagt tctcgttcgc
     2701 ctgtgcagga aagaccccca aaccgcgata cccactgacc tttatttttc cgagaaaaac
     2761 aggaactgcg gttgccgcgt tagcagcttt tagagttctc gttcgcctgt gcaggaaaga
     2821 ccccaaccgc ggtacccact gatctttatc tttatgaaga aaaacaggaa ctgcggttgc
     2881 cgcgttagca gcttttagag ttctcgttcg cctgtgcagg aaagacccca aaccgcggta
     2941 cccactgact tttagttttc cgagaaaaac agaaactgcg gttgccgcgt tagcagcttt
     3001 tagagttttc gttcgcctgt gcaggaaaga ccccaaaccg cggtacccac tgacttttaa
     3061 ttttccgaga aaaacagaaa ctgcggttgc cccgttagca gattttagag ttctcgttcg
     3121 cctgggcagg aaagacccca accgcggtac ccactgatct ttatctttat gaagaaaaac
     3181 aggaactgcg gttgccccgt tagcagattt tagagttctc gttcgcctgg gcaggaaaga
     3241 cccccaaacc gcggtaccca ctgaccttta tttttccgag aaaaacagca actgcggttg
     3301 ccccgttagc agattttaga gttctcgttc gcctgggcag gaaagacccc aaccgcggta
     3361 cccactgatc tttatcttta tgaagaaaaa caggaactgc ggttgtcgcg ttagcagctt
     3421 ttagagtttt cattcgcctg tgcaggaaag accccaaccg cggtacccac tgacttttaa
     3481 ttttccgaga aaaacagaaa ctgcggttgc cccgttagca gattttagag ttctcgttcg
     3541 cctgggcagg aaagacccca accgcggtac ccactgatct ttatctttat gaagaaaaac
     3601 aggaactgcg gttgccccgt tagcagattt tagagttctc gttcgcctgg gcaggaaaga
     3661 cccccaaacc gcggtaccca ctgaccttta tttttccgag aaaaacagca actgcggttg
     3721 ccccgttagc agattttaga gttctcgttc gcctgggcag gaaagacccc aaccgcggta
     3781 cccactgatc tttatcttta tgaagaaaaa caggaactgc ggttgccccg ttagcagatt
     3841 ttagagttct cattcgcctg ggcaggaaag accccaaccg cggtacccac tgacctttaa
     3901 ttttccgaga aaaacagaaa ttgcggttgc cgcgttagca gcttttagag ttttcattcg
     3961 cctgtgcagg aaagacccca accgcggtac ccactgactt ttaattttcc gagaaaaaca
     4021 gaaactgcgg ttgccccgtt agcagatttt agagttctcg ttcgcctggg caggaaagac
     4081 cccaaccgcg gtacccactg atctttatct ttatgaagaa aaacaggaac tgcggttgcc
     4141 ccgttagcag attttagagt tctcattcgc ctgggcagga aagaccccca aaccgcggta
     4201 cccactgacc tttatttttc cgagaaaaac agcaactgcg gttgccccgt tagcagattt
     4261 tagagttctc gttcgcctgg gcaggaaaga ccccaaccgc ggtacccact gatctttatc
     4321 tttatgaaga aaaacaggaa ctgcggttgc cccgttagca gattttagag ttctcattcg
     4381 cctgggcagg aaagacccca accgcggtac ccactgacct ttaattttcc gagaaaaaca
     4441 gaaattgcgg ttgccgcgtt agcagctttt agagttttca ttcgcctgtg caggaaagac
     4501 cccaaccgcg gtacccactg acttttaatt ttccgagaaa aacagaaact gcggttgccc
     4561 cgttagcaga ttttagagtt ctcgttcgcc tgggcaggaa agaccccaac cgcggtaccc
     4621 actgatcttt atctttatga agaaaaacag gaactgcggt tgccccgtta gcagatttta
     4681 gagttctcat tcgcctgggc aggaaagacc cccaaaccgc ggtacccact gacctttatt
     4741 tttccgagaa aaacagcaac tgcggttgcc ccgttagcag attttagagt tctcgttcgc
     4801 ctgggcagga aagaccccaa ccgcggtacc cactgatctt tatctttatg aagaaaaaca
     4861 ggaactgcgg ttgccccgtt agcagatttt agagttctca ttcgcctggg caggaaagac
     4921 cccaaccgcg gtacccactg acctttaatt ttccgagaaa aacagaaatt gcggttgccg
     4981 cgttagcagc ttttagagtt ttcattcgcc tgtgcaggaa agaccccaac cgcggtaccc
     5041 actgatcttt atctttatga agaaaaacag gaactgcggt tgccccgtta gcaattttta
     5101 aggttctaac ccgcttgggt aggaaagacc ctaaccacaa cacccactga cctttaactt
     5161 tatggaaaaa caaattattt tgctcaccat gcagtttttt atatatcgtt atatctctac
     5221 ccaatcagca cccttgatga tgcatacatt aagggaatgt tgattttttt ttcattgtac
     5281 ccacttacga ataacgaatc agaagccaga aagtagaata ttttaatgat gtattactca
     5341 tcatttccta ccacacctat taacttcagt atttatagga gaggcatttt tccgttatgc
     5401 gccattagct gttcttctgc taactcggac gcagcggtac agggtgagtt atcagtgtct
     5461 tataatgtga tgtctttttt ttattttctt gtcggtattt taaaagtggt cttttaagat
     5521 gttgttaaat atatagttat aaaattttcg gaaccgtgta gtcaataaaa caatttatag
     5581 aacggttcct ggcccaaaac agaaattgat ttatgtcgtc tttctgaatt acaggaaaat
     5641 tgcgagggat gactttatca aatgtaaaat tatataccct ctgtgataga tttattttgt
     5701 ggagattgga atgtaccatc gagcgtatat caacgcaaga tgtggctatg atgggacacg
     5761 gtcctatctg tacatggtcg ttttcattaa tcggaaatat tattttttga cctccaagga
     5821 gggattttat aatattaaaa ttgtcaaagt tgatacttat gtctttccac cacaagacta
     5881 aaacctgtcc gtaagctctt aaattttttg tattcagaga tccatgtaat attccatgta
     5941 acgggatgtt ttcaagaatg gctcccgtta acatcgattt tccacatccg ggtggaccga
     6001 taaaactaac ggtgtttttt tttcctcctc tgtggcttag ccactgatat aatatggttc
     6061 ctgctaatat agggtcaaaa gactgcagac agaacagctg gtaaaccggg ttttcataaa
     6121 tctgaaagtc agtgtctatg tgcgctataa aatcgatagc tttcctagtt gctcttattc
     6181 tttttttagc tatagataga gccctatgga ttagcacgtc cccgtgtgtt agcgtcaaca
     6241 attgcatgta tgatctaatg tctcttcgta tccacgcgtc ttccgtgact attccgagat
     6301 cagacagcca ttcgatggtt cccagaaatt tagattttaa agatatcccg ttaatcccat
     6361 cctttggaaa cagcataagt ttgacattag gttttttatt aaaatgggat atgatgtgtt
     6421 ttcgatgtat ctcatcgcat acgtctccca gttcgttaat atttgtccac gcccattgga
     6481 actgtggtct aataatttga agaagggcaa aggggatgta acttagactg aagacctggg
     6541 ttccgccacc attcttcttt gttttggcat acgtgcacca atcatctatt ttaggggcgt
     6601 tcccgtcgaa gaaatcttta attaatacgc ccctgatttc cgttgtgtgt tttcctatcg
     6661 ttgcgctggg aattccatct aaagctatca ataatattag ggagggtctg ccagctttat
     6721 tctccgcttg agcgtaccac tttgcagggg tggggacggc agttttatta ttccagtaat
     6781 tgagtatgac atcgatcatt ttggtacatg cagttatcca tttaatatcg ggcgctcccg
     6841 gtgagtgcat atccctgaaa tgtggcacgg acacgttaga gaatttacag aaaaaatccg
     6901 tagatattcc agggatttct gcctcccact ccatggggcc tttgatagtc aacatgatat
     6961 atttgtcctt agtccagaaa tcatcactcg gatttattat ggaaaacata ccgtttgcgc
     7021 ctcccaagtt ttttatagtt gtatacggaa aataaggtaa ttcccctggc ttgtcacctc
     7081 tagatgtctg cacatccgga cgatttgttt tggcaacaaa ttctcaatat ggatccgacg
     7141 gaacttttgt cggacgatgt aatctcgtcc acgtgtgacg aaaacactgc agctggaact
     7201 gatattatgc agcctttgtg cgttgatatg tctgttcaac cgacgacatc ggggtgtcat
     7261 accggagcga tgatgtcaga ctcgtatttc tccaatgaca caccggatca aaactgccaa
     7321 tcgcattcga ctttgacgga cctttcgccg gaagacatga acaatcaaat caatgttcaa
     7381 cccaatcaga tgacctttca acccatttcc ccaccgatac aggatcaaaa ttatggctat
     7441 agcaataata tgattaatcc catcaaacct gcatcaatta tcaaattaca tggtcattcg
     7501 ataggagaaa tgacagttac agacccttcc tctcatgtta atgctcaaca ctttgtccaa
     7561 cagtctaatc ctaaattctt tctaaatatg tatccgtgca tgaccgctaa ctcacaagga
     7621 cccggagaat gtcagtctgt ccataatcaa tcttctggaa gcgggtctaa ttcttatgac
     7681 attaatacgg caccccgcga tgaatggata ttcactacat ccggcggaga atcctgggtt
     7741 ctgaaacgga acacccctaa tcctccaaat agcagaacta atttaatttt caacaacgca
     7801 caaccgattt tccataccca acctcaagta tctgggttta gcgactgttc ctatcagggg
     7861 ggtggtctca attcacgtga gtatgtaaat ttggcaggtt acactcccgt gtgcaacatg
     7921 cagaatatca aaaactcatg ggcgacacaa ctaggagcat ccattgactg catgactgcg
     7981 tcaccaactg gtatagatgc gaatgtcaac tctgctttcc agccggtggg ggtggtatca
     8041 aataatcggg gtgctaatgt ttcaatggga ggcatgggta attatataga gaataacagt
     8101 ccatggaacc aatactataa atcggaaatg gctaataatt ccataaatgt caaggagtcg
     8161 aatgtttatg gccatgtggg gtgtgttaat gacgccattt ccgataaaca aggtggcacc
     8221 gctaacgtcc catcttctct attgaatccg gatcaccaag attggatgag gatgactggt
     8281 acgaacacac atatgttaaa caatataaat actaacacag aaatggaaaa ctatgatttt
     8341 ccggaaaatg atggcaatgt ccacggagcc accggtgtag atttatcaac cctgtccaat
     8401 ggtcagcagc atagcgcatt tgaaggaaat ggaacatttc ccgtggtaaa caccggcaat
     8461 ccaagaacga cgttgaactg tgctcctcag ttgttcttgc ttggaggaaa cccgacaatt
     8521 gcacatccaa tgaatgggaa taatgaaacc ccagataaaa atgtatgcaa gcctaccccc
     8581 agcacaggtg taataaaaaa attaaacttt gacggtgttg accgaggggg aggaatagga
     8641 aattttccca aactggcgtc ttttgtagct atgagagaaa aaatgtcaaa cacggtcaat
     8701 ccttcttgtg gaacttttct agaacagttg gagggattac gccagcagaa ttcatttgaa
     8761 aaaaatatat cctttgctga tctacatttt tctgaagaag atgatgtgct ttccagtgca
     8821 tcctcggtca gctgtaatag caactgcgac atgaaaatcg aagtttcgca gcaaggtatc
     8881 actgtgtcta atttacaaca aggatttagg caacaaatga acatgaactc atccgtggtt
     8941 aaaatggacg ggagctataa aacacaagag atgtcaaatg gctgcgcgac agacgtcacg
     9001 gataatgcag gcaccattca acaaaataaa cgtatacact ctcaaaatga gaatccagag
     9061 gatggccagg tacgggaggg agggtgttca gacgtcagaa atgaacctcc gcggaaaagt
     9121 gcgcgtattc ataacatgaa gtccgaaggc gtgacttgcg gtatgtgcat gacggctgcg
     9181 gattccacac ggcaggatgc gtctggaggt tcgagcagcg gaaccaagaa tgaatattac
     9241 gatgatgaat cggaattaac cggattgtcg gatacagaca gcgacaacga agtccaatgc
     9301 tgtcaagaag taacaaaggt cggccccaag acgtactcct cagaaaactt taatcctgag
     9361 tatcgccaag ccaagagatt gcttgccgac attccataca gaagatggat tccagaccca
     9421 gtcaatatgg aagacaacga cggtccgttc attccaatag tgactagacc agccactgtg
     9481 tgtatgaacg gtagacgccg gaggactttc ttccggcaat gtgttaccgc tttcggtcct
     9541 ctgagtaagt taacttattt caaagaatta ctgcagagct acgtgtccaa aaataacaat
     9601 agttatttaa gtatcagttg gcctcccaaa cacggggtat atgtcatgtc agagaagaaa
     9661 ttagggtatg aacatatacc taccttgaag gacaagtttc cactgccatg tgggtggatg
     9721 atggtccttg gagttgtcgg tgcagaaccg cccgcggctc tgaataaaaa catggtgatt
     9781 ctcctgtgtg aaaatagatg ggtgcttctg cataattact caaactctac acacgagctg
     9841 tttttagccg cctcggattt gaaacagttt atggaggagg gtctgtctag atgtgatcct
     9901 atatatgaag aatcaacagt gccgtacggt gtggccatgg aaaactctct tcgagatttc
     9961 ttgagaaaca gtagaacgtt tcaggatctt atggatcaaa gggacaacat gcacggatgt
    10021 aactggacct ttaacggaat gcctggtaga ctaggtgaca gagtcataca tctctgcaat
    10081 cctgaatcgg ttgattccat accaggagac gaggccgtcg tatgtgaagg aagacccttg
    10141 tatttctttg catatgttac cactttcaaa tcaaaccccg ctactaaggc taccgtgtta
    10201 atagccgcgg ataaagattt aagaatatat ggctatcata aaggtcgccc caggatacgg
    10261 tacttgtgta agaacgtaaa aactttcttt aaagccgggg ctagaaagtt ctatttagat
    10321 tttcagatta cacctaaaag gttgcttgcc gtcaacgaag aggagtatct gaatactcta
    10381 caaaacgctc cttgtctgct cttaaaacca tctgtgttta gaaatattta ctctcaggaa
    10441 ggtaaataag aattcctatg tcaatagttt tacttcacag tccccaccct ctttttttaa
    10501 ttaaaacaga aaggccgttg gatccaatct accgagagat ttactgtttc tttgacattt
    10561 attagggata cgtatattgt gtaccttgta atttctatgt aaacttctgc tatttttttt
    10621 aatgttgagt aattgaacat tgtaaatagg taaactgttt tttcaaaatg gttagaaatt
    10681 ctatgtactt attttttttt ctgtgtattg taaaagggaa gatttgtaag gacaaagttc
    10741 agtaacattt aataaagaac atgtgacacg atttctgact ctctcagtaa tttgtgtaat
    10801 ttaataagag ccaataccaa cgtgagggaa acgtaggttc cggccaaggt gaggaaaacg
    10861 gaggttcctg ccaaggtgag ggcaacgtag cttccgaggg ataaaaaagt aattcgttac
    10921 tatgagtagt cggataaaac atttgtagtt ttttgtctaa cacataataa ttatcttgat
    10981 aacattcatg tcggaataaa tccgatataa acgtttccat ctgtagatat cttggcccgt
    11041 tttccatctg tagatatctt ggcccgtttt tgcgtgccaa catagcactt ttggttaaat
    11101 tgtttatcac atctcttccg tagtcactta aaaaaaaaac aaaaaagaca tgaaatgtta
    11161 tagtcggcct acctgcaatt tatataagta caaataaaca cagtaaaaat aaaatgattc
    11221 acatatggat taatacctaa tgactagatt gaaatccatc cacgttacgg acaagggttt
    11281 ttgaacttgg tcttgcatgg tatatacaat tgttctattg tccgtgagag gtcgacaaaa
    11341 cttctggcct tcattttgaa acagactgaa caaatatcaa gttataaatt aaccggcgat
    11401 gtcctgtgtt attactcaga ctatacatcc acatgcacac acgataaaat ggtatagtaa
    11461 tcattcaggt ttacccgagg tgacgttttc cccgagtaaa tcgaacgata cttacatttc
    11521 accgtctagg caggtcgaaa tcaaggaaga gacagaagtc gatgagttaa gaacgacata
    11581 gctatcacag cacgaagtaa tcttcggtaa cgtgctaaaa agcggtagcg cagccattcc
    11641 acgatatgca tggaaatgta ttaaaatata cacaaccaag aaatgcataa ttatctagca
    11701 gcaatatagt ttgttattca aacaatgatt cttttatctt catttaaata taatatgaat
    11761 atttacagct atatatacaa ttcaatatac acatggtcga taacgcacta tttatatatt
    11821 ccaaaaaaca acaaaagtta tcgggggtta tatttatcta catcgataaa gtgtacaaat
    11881 gtatatgtaa acacaacagg aaaatataca tgtcccaagg cgtatacatt ctaacacgcg
    11941 cacataacgg tcaggtcctc acgacagtag gttttatatt tatcattttg atgttttcag
    12001 attttacttc tttcggattg taaaatacgt gcccaccctg acataaagct t
//