From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Murine leukemia virus reverse transcriptase, integrase, and
Date: 31 Jul 92 10:01:47 GMT
Distribution: bionet
Checksum: 03257     9

LOCUS       MLVPOLENV    4298 bp ds-DNA             VRL       31-JUL-1992
DEFINITION  Murine leukemia virus reverse transcriptase, integrase, and
            envelope genes.
ACCESSION   M93052
KEYWORDS    envelope protein; integrase; reverse transcriptase.
SOURCE      Murine leukemia virus DNA.
  ORGANISM  Murine leukemia virus
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Retroviridae; Oncovirinae; Type C oncovirus group;
            Mammalian type C oncoviruses; Murine leukemia viruses.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Poliquin,L., Bergeron,D., Fortier,J.-L., Paquette,Y., Bergeron,R.
            and Rassart,E.
  TITLE     Determinants of thymotropism in kaplan radiation leukemia virus and
            nucleotide sequence of its envelope region
  JOURNAL   J. Virol. 66, 5141-5146 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             1..1746
                     /gene="pol"
                     /codon_start=1
                     /translation="LEILAETHGTRPDLTDQPIPDADHTWYTDGSSFLQEGQRKAGAA
                     VTTETEVIWARALPAGTSAQRAELIALTQALKMAEGKRLNVYTDSRYAFATAHIHGEI
                     YKRRGLLTSEGREIKNKSEILALLKALFLPKRLSIIHCLGHQKGDSAEARGNRLADQA
                     AREAAIKAPPDTSTLLIEDSTPYTPAYFHYTETDLKKLRELGATYNQSQGYWVFQGKP
                     VMPDQFVFELLDSLHRLTHLGYQKMKALLDRGESPYYMLNRDKTLQYVADSCTVCAQV
                     NASKAKIGAGVRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKHE
                     TAKIVTKKLLEEIFPRFGMPQVLGTDNGPAFVSQVSQSVAKLLGIDWKLHCAYRPQSS
                     GQVERMNRTIKETLTKLTLATGTRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPP
                     LVNFHDPEMSKFTNSPSLQAHLQALQAVQREVWKPLAAAYQDQLDQPVIPHPFRVGDT
                     VWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGISAWIHAAHVKAATTPPIRPSWRVQ
                     RSQNPLKIRLTRGAP"
                     /partial
     CDS             1686..3683
                     /gene="env"
                     /codon_start=1
                     /translation="MESTTLSKPFKNQVNPWGPLIVLLILGRVNPVALGNSPHQVFNL
                     SWEVTNEDRETVWAITGNHPLWTWWPDLTPDLCMLALHGPSYWGLEYQAPFSPPPGPP
                     CCSRSSGSTPGCSRDCEEPLTSYTPRCNTAWNRLKLSKVTHAHNEGFYVCPGPHRPRW
                     ARSCGGPESFYCASWGCETTGRASWKPSSSWDYITVSNNLTSGQATPVCKNNTWCNSL
                     TIRFTSLGKQATSWVTGHWWGLRLYVSGHDPGLIFGIRLKITDSGPRVPIGPNPVLSD
                     QRPPSQPRSPPHSNSTPTETPLTLPEPPPAGVENRLLNLVKGAYQALNLTSPDRTQEC
                     WLCLVSGPPYYEGVAVLGTYSNHTSAPANCSVASQHKLTLSEVTGRGLCVGAVPKTHQ
                     ALCNTTQNTSGGSYYLAAPAGTIWACNTGLTPCLSTTVLNLTTDYCVLVELWPRVTYH
                     SPSYVYHQFEGRAKYKREPVSLTLALLLGGLTMGGIAAGVGTGTTALVATQQLQAAVH
                     DDLKEVEKSITNLEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGV
                     VRDSMAKLRERLNQRQKLFESGQGWFERLFNGSPWFTTLISTIMGPLIVLLLILLLGP
                     CILNRLVQFVKDRISVVQALVLTQQYHQLKSIDPEEMESRE"
     sig_peptide     1686..1778
                     /codon_start=1
     misc_feature    1779..3086
                     /note="gp70 region"
     misc_feature    3087..3684
                     /note="p15 region"
     LTR             3716
                     /note="beginning of LTR"
BASE COUNT     1145 a   1238 c   1011 g    904 t
ORIGIN
        1 ctcgagatct tggctgaaac gcatggaacc agaccggatc tcaccgacca gcccatccca
       61 gacgccgacc acacctggta taccgatggg agcagctttt tgcaagaagg acagcggaag
      121 gctggggcag cggtgaccac tgagaccgag gtaatctggg caagggcact gccggctgga
      181 acatctgccc aacgggccga actgatagca ctcactcaag ccttgaagat ggcagaaggt
      241 aagaggctaa acgtttacac tgacagccga tatgctttcg ccacggccca tatccatgga
      301 gagatctata agaggcgagg gttgctaacc tcagagggta gagaaatcaa aaacaagagc
      361 gagatcctgg ctttactgaa agctcttttt ctgccaaaga gactcagtat aatccactgc
      421 ctggggcatc aaaaaggaga tagtgccgag gctaggggca accgcctagc agaccaagcg
      481 gcccgggagg cagccataaa ggcgcctcca gatacatcca ctctccttat agaggattca
      541 accccataca cgcctgccta tttccattat actgaaacag atctaaagaa actcagagag
      601 cttggggcca cctataacca gagccaagga tactgggtct tccaaggcaa gccggtgatg
      661 cccgaccaat ttgtatttga actgttagac tcactccacc ggctcaccca cctcggctac
      721 cagaaaatga aagcactcct tgacagagga gaaagcccct actacatgct aaaccgggac
      781 aaaaccctcc aatatgtggc agattcatgc acggtctgtg cccaagtgaa tgccagcaaa
      841 gctaaaatcg gggcaggagt aagagtacga ggacatcgac caggcaccca ttgggagatc
      901 gattttacag aagtcaagcc agggctgtat gggtacaagt atctcctggt gttcgtagac
      961 acgttctctg gctgggttga agccttccca accaaacatg agactgccaa aatagtgacc
     1021 aagaaacttc tggaagaaat atttccaagg tttggaatgc cccaagtgtt ggggactgat
     1081 aatgggcctg ccttcgtctc ccaggtaagt cagtcggtgg ccaagctact ggggattgat
     1141 tggaaactac attgtgctta cagaccccag agttcaggtc aggtagaaag aatgaatagg
     1201 acaatcaagg agactttgac caaattaacg cttgcaactg gcactagaga ctgggtactc
     1261 ctactcccct tagccctcta ccgagcccgc aacactccgg gcccccatgg actcactcca
     1321 tatgaaatcc tgtatggggc gcccccgccc cttgttaatt tccatgatcc tgaaatgtca
     1381 aagtttacta atagcccctc tctccaagct cacttacagg ccctccaagc agtacaacga
     1441 gaggtctgga agccactggc cgctgcctat caggaccagc tggaccagcc agtgatacca
     1501 caccccttcc gtgtcggcga cactgtgtgg gtacgccggc accagactaa gaacttagaa
     1561 cctcgctgga aagggcccta caccgtccta ctgaccaccc ccaccgctct caaggtagac
     1621 ggcatctctg catggataca cgccgcccac gtcaaggcag cgaccacacc cccgataaga
     1681 ccgtcatgga gagtacaacg ctctcaaaac cctttaaaaa tcaggttaac ccgtggggcc
     1741 ccctaattgt ccttctgatt ctcggaaggg tcaaccccgt tgcgttggga aacagccccc
     1801 accaggtttt taacctctcc tgggaagtga ctaatgaaga ccgagaaacg gtgtgggcaa
     1861 taaccggcaa tcaccctctg tggacttggt ggcctgacct cacaccagat ctctgtatgt
     1921 tggccctcca cgggccgtcc tattggggcc tagaatatca ggctcctttt tctcctcccc
     1981 cggggccccc ctgctgttca agaagcagcg gctccacgcc aggctgttcc agagattgtg
     2041 aggagcccct gacttcatat actccccggt gcaatacggc ctggaacaga cttaagttat
     2101 ctaaagtgac acatgcccac aatgaaggat tctatgtctg ccccgggcca catcgccccc
     2161 ggtgggcccg gtcgtgtggt ggtccagaat ccttctattg tgcctcttgg ggctgcgaaa
     2221 ccacaggccg agcatcctgg aaaccatcct catcctggga ctacatcaca gtaagcaaca
     2281 atctaacctc aggccaggca accccagtat gcaaaaataa tacgtggtgc aattccttaa
     2341 ctatcaggtt cactagcctt ggaaaacagg ccacctcctg ggtcacaggc cattggtggg
     2401 gattgcgcct atacgtctct ggacatgacc cagggctcat ctttgggatc cgacttaaaa
     2461 ttacagactc ggggccccgg gtcccaatag ggccaaaccc cgtcttgtca gaccaacgac
     2521 caccttccca gcctagatct cccccgcatt caaactccac cccaaccgag acacccctca
     2581 ccctccccga acccccgcca gcgggagtcg aaaaccgatt gttaaatcta gtaaaaggag
     2641 cctaccaagc cctcaacctc accagtcctg atagaaccca agagtgctgg ttatgcctag
     2701 tatcgggacc cccatattac gagggggttg ccgtcctagg tacctactcc aaccatactt
     2761 ctgccccagc taactgctcc gtggcctcac aacacaagct gaccctgtcc gaagttaccg
     2821 gacggggact ctgcgtagga gcagttccca aaacccatca ggccctgtgt aataccaccc
     2881 agaatacaag cggcgggtcc tactatctgg ctgctcccgc cgggaccatt tgggcttgca
     2941 acaccgggct cactccctgc ctatctacta ctgtactcaa cctcaccacc gattactgtg
     3001 tcctggttga gctctggcca agggtgacct accattcccc tagttatgtt taccaccaat
     3061 ttgaaggacg agccaaatat aaaagagaac ccgtctcact aactctggcc ctactattag
     3121 gggggctcac tatgggcgga attgccgctg gagtaggaac agggactacc gccctagtgg
     3181 ccactcaaca actccaggct gccgtgcacg atgaccttaa agaagttgaa aaatccatca
     3241 ctaatctaga aaaatctttg acctccttgt ccgaagtagt gttacagaat cgtagaggcc
     3301 tagatctact attcctaaaa gagggaggtt tgtgtgctgc cctaaaagaa gaatgctgtt
     3361 tctatgcaga ccacactggc gtagtaagag atagcatggc taagctaaga gagaggctaa
     3421 accagagaca aaaattgttc gaatcaggac aagggtggtt tgagagactg ttcaacgggt
     3481 ccccatggtt cacgaccctg atatccacca ttatgggccc tctgatagta cttttattaa
     3541 tcctactcct cggaccctgc attctcaacc gcttggtcca gtttgtaaaa gacagaattt
     3601 cagtggtaca ggccctggtt ctgacccaac agtatcacca actcaaatca atagatccag
     3661 aagaaatgga atcacgtgaa taaatgattt tattcagttt ccagaaagag gggggaatga
     3721 aagaccccac cataaggctt agcaagctag ctgcagtaac gccattttgc aaggcatgga
     3781 aaagtaccag agctgagttc tcacaagtta caaagaagtt tagttaaagg ctgaataata
     3841 ctgagaaagg ggccgaacag gatatctgtg gtcaagcacc tgggccccgg ctccgttaga
     3901 cataggccaa acaggatatc tgtggccaag cacctgggcc ccggctcagg gccaaaaaca
     3961 gatagtactc agataaagtg aaactaacaa cagtttctgg aaagtcccac cgcagtttca
     4021 ggttccccaa acgaccgaga gataccccaa gccttattta aactaaccaa tcagctcgct
     4081 tctcgcttct gtacccgcgc tctttgcccc cccagcccta gccctataaa aagggtaaga
     4141 actccacact cggcgcgcca gtcctccaac cgactgagtc gcccgggtac ccgtgtatcc
     4201 aataaagcct tttgctgttg catccgaatc gtggtctcgc tgatccttgg gagggtctcc
     4261 tcagagtgat tgactgccca gcttgggggt ctttcatt
//