From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Bos taurus antigen CD18 (CD18) mRNA, complete cds.
Date: 11 Sep 92 10:02:25 GMT
Distribution: bionet
Checksum: 12623     7

LOCUS       BOVCD18A     2817 bp ss-mRNA            MAM       11-SEP-1992
DEFINITION  Bos taurus antigen CD18 (CD18) mRNA, complete cds.
ACCESSION   M81233
KEYWORDS    antigen CD18.
SOURCE      Bos taurus (strain Holstein) cDNA to mRNA.
  ORGANISM  Bos taurus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae;
            Bovini.
REFERENCE   1  (sites)
  AUTHORS   Shuster,D.E., Bosworth,B.T. and Kehrli,M.E.Jr.
  TITLE     Sequence of the bovine CD18-encoding cDNA: comparison with the
            human and murine glycoproteins
  JOURNAL   Gene 114, 267-271 (1992)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Shuster,D.E., Bosworth,B.T. and Kehrli,M.E.
  TITLE     Sequence of the bovine CD18-encoding cDNA: comparison with the
            human and murine glycoproteins
  JOURNAL   Gene 114, 267-271 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             106..2415
                     /product="antigen CD18"
                     /gene="CD18"
                     /codon_start=1
                     /translation="MLRQRPQLLLLAGLLALQSVLSQECTNYKVSTCRDCIESGPGCA
                     WCQKLNFTGQGEPDSIRCDTRAELLSKGCPADDIMEPKSLAETRDSQAGSRKQLSPQE
                     VTLYLRPGQAVAFNVTFRRAKGYPIDLYYLMDLSYSMVDDLVNVKKLGGDLLRALNGI
                     TESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFE
                     TEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLG
                     AILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLT
                     EIIPKSAVGELSEDSRNVVELIKNAYNKLSSRVFLDHSTLPDTLKVTYDSFCSNGKSQ
                     VDQPRGDCDGVQINVPITFQVKVTATECIQQQSFTIRALGFTDTVTVRVLPQCECQCR
                     DASRDGSICGGRGSMECGVCRCDAGYIGKNCECQTQGRSSQELEGSCRKDNSSIICSG
                     LGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGEKRGLCFCGTCRCDE
                     QYEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCSECPGCPVPCAG
                     FAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGRKCKERDSEGCWMTYTLVQRDGR
                     DRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLVIWKALTHLSDLREYHRFEK
                     EKLKSQWNNDNPLFKSATTTVMNPKFAES"
                     /citation=[2]
     mutation        488
                     /phenotype="bovine leukocyte adhesion deficiency"
                     /note="G in mutation"
                     /gene="CD18"
                     /citation=[1]
     mutation        880
                     /phenotype="silent mutation"
                     /note="T in mutation"
                     /gene="CD18"
                     /citation=[1]
     misc_signal     2734..2741
                     /function="involved in translational regulation"
                     /gene="CD18"
                     /citation=[2]
BASE COUNT      621 a    863 c    841 g    492 t
ORIGIN
        1 gtcttcccag atccgcgaag caccagcctg gtgaagagca gagccgaagc ccctgccagt
       61 ccagctggga cacccctgcc gaggtctcca gggcatccag gggacatgct gcgccagcgc
      121 ccccagctgc tgctcctagc gggcctgctt gccctccagt ccgtcctgtc ccaggagtgc
      181 accaactaca aggtcagcac ctgccgggac tgcatcgagt cgggccccgg ctgcgcctgg
      241 tgccagaaac tgaacttcac agggcaaggg gagcccgact ccattcgctg tgacacacga
      301 gcggagctgc tgtcaaaggg ctgcccagct gatgacatca tggaacccaa gagcctcgct
      361 gagacccggg acagccaggc gggcagtcgg aagcagctgt ccccacagga agtgacgctc
      421 tacctgagac caggtcaggc agttgcgttc aacgtgacct tccggagggc caagggctac
      481 cccatcgacc tgtactacct gatggacctc tcctactcca tggtggatga cctcgtcaac
      541 gtcaagaagc tggggggtga cctgctccgg gccctcaatg gcatcaccga gtcgggccgc
      601 attggtttcg ggtccttcgt ggacaagacg gtgctcccct tcgtcaacac gcaccccgag
      661 aagctgcgga acccctgccc caacaaggag aaggagtgcc agcccccgtt cgccttcagg
      721 cacgtgttga agctcactga caactccaaa cagttcgaga cagaagtcgg gaagcagctg
      781 atctcgggga acctggacgc ccctgagggt gggctggacg ccatgatgca ggtggccgcg
      841 tgcccggagg aaatcggctg gcgcaatgtc accaggctgc tggtgttcgc cacggacgat
      901 gggttccact ttgcgggcga tggaaagctg ggtgccatcc tcacccccaa tgacggccgc
      961 tgccacctgg aagacaacct gtacaaaagc agcaacgaat ttgactaccc atcggtgggc
     1021 cagctggcac acaaactggc agaaagcaac atccagccca tctttgcagt aaccaagaag
     1081 atggtgaaaa cgtacgagaa gctgacagag atcatcccca agtctgcagt cggggagctg
     1141 tctgaagatt ccaggaacgt ggtggagctt atcaagaatg cctacaataa actgtcctcc
     1201 agagtcttcc tggatcacag caccctccct gacaccctga aagtcaccta cgactccttc
     1261 tgcagtaacg ggaaatcgca ggtggaccag cccagagggg actgcgacgg cgtccagatc
     1321 aacgtcccga tcaccttcca ggtgaaggtc acagccaccg agtgcatcca gcagcagtcc
     1381 ttcaccatcc gggcgctggg cttcacggac acggtgaccg tgcgggtcct cccccagtgc
     1441 gagtgccaat gccgggacgc cagcagggac ggcagcatct gcggcggcag aggctcgatg
     1501 gagtgcggcg tctgcaggtg tgacgccggc tacatcggga agaactgcga gtgccagacg
     1561 cagggccgga gcagccagga gctggagggc agctgccgca aggacaacag ctccatcatc
     1621 tgctcggggc tgggggactg catctgcggg cagtgcgtgt gccacacgag cgacgtgccc
     1681 aacaagaaga tctacggcca gttctgcgag tgcgacaacg tcaactgcga acgctacgac
     1741 ggccaagtct gcgggggcga aaagaggggg ctctgcttct gcggcacctg caggtgcgac
     1801 gagcagtatg agggttcggc atgccagtgc ctcaagtcca ctcagggctg cctcaacttg
     1861 gacggcgtcg agtgcagcgg ccgcggccga tgccgctgca atgtgtgcca gtgcgacccc
     1921 ggctaccagc cgcccctgtg cagcgagtgc ccgggctgcc ccgtgccctg tgcgggcttc
     1981 gccccctgca cagagtgcct gaagttcgac aagggcccct tcgccaagaa ctgcagcgca
     2041 gcgtgcgggc agacgaagct gctgtccagc ccggtgcccg gccgcaagtg caaggagcgc
     2101 gactccgagg gctgctggat gacctacacc ctggtgcagc gcgacgggcg ggacagatac
     2161 gacgtgcacg tggacgacat gctcgagtgt gtgaagggcc ccaacatcgc tgccatcgtg
     2221 gggggcaccg tggggggcgt cgtgctcgtc ggcatcctcc tgctggtcat ctggaaggcc
     2281 ctgacacacc tgagcgacct cagggagtac catcgctttg agaaggagaa gctcaagtcc
     2341 cagtggaaca acgataaccc tcttttcaag agtgccacca cgacagtcat gaaccctaag
     2401 tttgccgaga gttaggggtg cccggtgaag acaaggcctt ctgcaccacc cagatgggaa
     2461 caccccctct ccacgtcccc tccagcaggc tgaccgtgac cccgctgcct cgtggacgtg
     2521 gctgacaact tcaccgttaa ccaaaaatgc actgcttttt ctgccccaga atgatgggcg
     2581 tggccaggtt attctatggg ctcatggtaa gggccagcct accccttctg atatgaatga
     2641 cttttgatag caagtcagag aaggaattgc ctacattttg tatggttaca cacaggtcct
     2701 ttgtaaaaat tagtacagca gtctgatgaa gaattattta tgtgtgaact tctcagggta
     2761 tgaagttaca tccccttggt tatgctgccc ccaatcaata aaaaaaaaaa aatcaat
//