From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human multidrug resistant P glycoprotein (MDR1; PGY1) gene, 5'
Date: 29 Dec 92 19:49:38 GMT
Distribution: bionet
Checksum: 17582 4

LOCUS       HUMMDR1P     1327 bp ds-DNA             PRI       09-DEC-1992
DEFINITION  Human multidrug resistant P glycoprotein (MDR1; PGY1) gene, 5'
            flank.
ACCESSION   L07624
KEYWORDS    MDR1 gene; P-glycoprotein; multidrug resistance protein.
SOURCE      Homo sapiens (library: lambda Charon 4a) bone marrow DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1327)
  AUTHORS   Madden,M.J., Morrow,C.S., Nakagawa,M., Goldsmith,M.E.,
            Fairchild,C.R. and Cowan,K.H.
  TITLE     Identification of 5' and 3' sequences involved in the regulation of
            transcription of the human mdr1 gene in vivo
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     protein_bind    863..875
                     /function="heat shock element"
                     /bound_moiety="unknown"
                     /gene="PGY1"
     protein_bind    930..937
                     /function="metal responsive element"
                     /bound_moiety="unknown"
                     /gene="PGY1"
     GC_signal       931..938
                     /gene="PGY1"
     GC_signal       980..990
                     /gene="PGY1"
     CAAT_signal     1023..1028
                     /gene="PGY1"
     exon            1041..1170
                     /number=1
                     /gene="PGY1"
     mRNA            1041..>1170
                     /gene="PGY1"
                     /note="major transcription start site"
     mRNA            1044..>1170
                     /gene="PGY1"
                     /note="minor transcription start site"
     protein_bind    1050..1066
                     /function="heat shock element"
                     /bound_moiety="unknown"
                     /gene="PGY1"
     intron          1171..>1171
                     /number=1
                     /gene="PGY1"
BASE COUNT      402 a    241 c    298 g    386 t
ORIGIN      
        1 agtcaagaat agaaaaaaat tatggctttg aagtatgagt tatttaaaga aagtggaaac
       61 atcctcagac tatgcagtaa aaaacaaagt gattttcttc ttctaaactt atgcaataaa
      121 ctgataggta atatgtgaaa gtcatagaat gtagactaga ggatacaaca aacctatttc
      181 ctctatgttc ataagaagta agaaaagctc tgatgtgagt tagcattgct ttacaatttt
      241 gaattgtgca gattgcacgt acttttcctc agtttgaagt aaatagtgga caggaaaaaa
      301 tattaaatgt tggcagtaaa tatggaagga aattacaact aatgtaatat gctaaaacat
      361 gctatgttta ttttactaat ttgaattaaa atgtaagaat ttaaaatgcc ctggaaaaac
      421 acgggcattg atctgacgtc tgaagtttta aaatattaca cactttgaaa tagcatttgt
      481 accttgaaat acctgtctct atatattttt taaaacttcc tttttctttc attccattta
      541 tcatcaaata aaggatgaac agatgtaact cagaaactgt caagcatgct gaagaaagac
      601 cactgcagaa aaatttctcc tagccttttc aaaggtgtta ggaagcagaa aggtgataca
      661 gaattggaga ggtcggagtt tttgtattaa ctgtattaaa tgcgaatccc gagaaaattt
      721 cccttaacta cgtcctgtag ttatatggat atgaagactt atgtgaactt tgaaagacgt
      781 gtctacataa gttgaaatgt ccccaatgat tcagctgatg cgcgtttctc tacttgccct
      841 ttctagagag gtgcaacgga agccagaaca ttcctcctgg aaattcaacc tgtttcgcag
      901 tttctcgagg aatcagcatt cagtcaatcc gggccgggag cagtcatctg tggtgaggct
      961 gattggctgg gcaggaacag cgccggggcg tgggctgagc acagccgctt cgctctcttt
     1021 gccacaggaa gcctgagctc attcgagtag cggctcttcc aagctcaaag aagcagaggc
     1081 cgctgttcgt ttcctttagg tctttccact aaagtcggag tatcttcttc caagatttca
     1141 cgtcttggtg gccgttccaa ggagcgcgag gtaggggcac gcaaagctgg gagctactat
     1201 gggacagttc ccaagtgtca ggctttcaga tttcctgaac ttggtcttca cgggagaagg
     1261 gcttcttgag gcgtggatag tgtgaagtcc tctggcaagt ccatggggac caagtggggt
     1321 tagatct
//