From: kristoff@GENBANK.BIO.NET (Dave Kristofferson)
Newsgroups: bionet.sci-resources
Subject: NIH Guide, vol. 21, no. 29, pt. 1, 14 August 1992
Date: 14 Aug 92 23:31:07 GMT
Distribution: bionet


NOTE: The NIH Guide may be split into more than one mail message to
avoid truncation during e-mail distribution.  The first message always
begins with the RFP/RFA summary sections followed by the appended
texts of the full RFP/RFAs.
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$$XID NIHGUIDE 19920814 V21N29 P1O2 ************************************
X-comment: RFAs described: AG-93-02, DE-92-04

NIH GUIDE - Vol. 21, No. 29 - August 14, 1992

$$INDEX BEGIN *******************************************************

                               NOTICES

$$INDEX N1 **********************************************************

LABORATORY ANIMAL SMALL RESEARCH GRANTS
National Center for Research Resources
INDEX:  RESEARCH RESOURCES

$$INDEX N2 **********************************************************

TERMINATION OF SMALL GRANTS PROGRAM FOR BIOETHICS AND CLINICAL DECISION
MAKING RESEARCH
National Center for Nursing Research
INDEX:  NURSING RESEARCH

$$INDEX N3 **********************************************************

NIDCD - INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS
National Institute on Deafness and Other Communication Disorders
INDEX:  DEAFNESS, OTHER COMMUNICATION DISORDERS

               NOTICES OF AVAILABILITY (RFPs AND RFAs)

$$INDEX R1 11/18/92 *************************************************

CENTERS OF RESEARCH ON APPLIED GERONTOLOGY (RFA AG-93-02)
National Institute on Aging
INDEX:  AGING

$$INDEX R2 12/03/92 *************************************************

CLINICAL CORE CENTERS FOR PREVENTIVE AND OPERATIVE DENTISTRY (RFA DE-
92-04)
National Institute of Dental Research
INDEX:  DENTAL RESEARCH

$$INDEX R3 11/06/92 *************************************************

SUPPLEMENTS FOR UNDERGRADUATE RESEARCH EXPERIENCE PROGRAM (RFA GM-92-
003)
National Institute of General Medical Sciences
INDEX:  GENERAL MEDICAL SCIENCES

                    ONGOING PROGRAM ANNOUNCEMENTS

$$INDEX P1 **********************************************************

RESEARCH CAREER DEVELOPMENT IN MYCOBACTERIUM TUBERCULOSIS (PA-92-96)
National Institute of Allergy and Infectious Diseases
INDEX:  ALLERGY, INFECTIOUS DISEASES

$$INDEX P2 10/01/92 *************************************************

DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES (PA-92-97)
National Center for Research Resources
INDEX:  RESEARCH RESOURCES

$$INDEX P3 **********************************************************

SCIENTIST DEVELOPMENT AWARD FOR CLINICIANS (PA-92-98)
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institute of Mental Health
INDEX:  ALCOHOL ABUSE, ALCOHOLISM; DRUG ABUSE; MENTAL HEALTH

$$INDEX P4 **********************************************************

SCIENTIST DEVELOPMENT AWARD (PA-92-99)
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institute of Mental Health
INDEX:  ALCOHOL ABUSE, ALCOHOLISM; DRUG ABUSE; MENTAL HEALTH

$$INDEX P5 **********************************************************

INTEGRATED ADVANCED INFORMATION MANAGEMENT SYSTEMS (PA-92-100)
National Library of Medicine
INDEX:  LIBRARY OF MEDICINE

                               ERRATA

$$INDEX E1 11/19/92 *************************************************

BIOTECHNOLOGY TRANSFER TO EPIDEMIOLOGIC STUDIES IN CANCER (RFA CA/ES-
92-23)
National Cancer Institute
National Institute of Environmental Health Sciences
INDEX:  CANCER; ENVIRONMENTAL HEALTH SCIENCES

$$INDEX E2 11/12/92 *************************************************

TRANSFER OF NEW BIOSTATISTIC METHODS TO CANCER EPIDEMIOLOGY (RFA CA-92-
21)
National Cancer Institute
INDEX:  CANCER

This publication is also available electronically to institutions via
BITNET or INTERNET.  Alternative access is through the NIH Grant Line
using a personal computer.  Contact Dr. John James at 301/496-7554 for
details, or send an E-mail message to ZNS@NIHCU.

$$INDEX END *********************************************************

                               NOTICES

$$N1 BEGIN **********************************************************

LABORATORY ANIMAL SMALL RESEARCH GRANTS

NIH GUIDE, Volume 21, Number 29, August 14, 1992

P.T. 34; K.W. 1002002, 0710035

National Center for Research Resources

This is to advise potential applicants that the National Center for
Research Resources (NCRR) Comparative Medicine Program will henceforth
accept Small Research Grant (R03) applications at any of the three
standard annual application receipt dates (February 1, June 1, and
October 1).  Such applications have previously been accepted only for
the February 1 deadline.  These awards are limited to $25,000 direct
costs and only one year of support.  They are intended to provide
support for pilot projects, testing of new techniques, and feasibility
studies of innovative research in the areas of laboratory animal
biotechnology, normative biology, disease, welfare, and model
development.

INQUIRIES

Further information concerning these awards and updated guidelines for
applicants may be obtained by sending two self-addressed mailing labels
to:

Comparative Medicine Program
National Center for Research Resources
Westwood Building, Room 857
Bethesda, MD  20892
Telephone:  (301) 496-5175

$$N1 END ************************************************************

$$N2 BEGIN **********************************************************

TERMINATION OF SMALL GRANTS PROGRAM FOR BIOETHICS AND CLINICAL DECISION
MAKING RESEARCH

NIH GUIDE, Volume 21, Number 29, August 14, 1992

P.T. 34; K.W. 1014004, 1014006

National Center for Nursing Research

The National Center for Nursing Research (NCNR) announces plans for the
orderly phase out and termination of its small grants program for
bioethics and clinical decision making research.  All non-competing
commitments for future year support made to current grantees will
continue to be honored, as will applications selected for award that
have completed the review process in FY 1992.  No new applications will
be accepted for review for FY 1993.

The NCNR continues to encourage potential investigators to use
alternative grant mechanisms, such as the R01 and R29, for addressing
bioethical and clinical practice studies.  Training in bioethics for
nurses also continues to be encouraged.

INQUIRIES

For additional information and for questions concerning this notice,
contact:

Dr. Barbara Pillar
Nursing Systems Branch
National Center for Nursing Research
Westwood Building, Room 754
Bethesda, MD  20892
Telephone:  (301) 496-0523
FAX:  (301) 402-2402

$$N2 END ************************************************************

$$N3 BEGIN **********************************************************

NIDCD - INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS

NIH GUIDE, Volume 21, Number 29, August 14, 1992

P.T.44; K.W. 0720005, 0715050, 0715055

National Institute on Deafness and Other Communication Disorders

The National Institute on Deafness and Other Communication Disorders
announces a new receipt and review cycle for Institutional National
Research Service Award (T32) applications.  Beginning in 1993, such
applications will be accepted and reviewed only once a year.  For this
annual cycle, applications will be accepted only for the May 10
deadline, and will receive initial review in October/November, followed
by National Advisory Council review in January.  Annual funding
decisions will be made shortly following the January Council meeting.
Most Institutional National Research Service Awards have had, and will
continue to have, July 1 start dates.

INQUIRIES

For more specific information and guidance, contact:

Daniel A. Sklare, Ph.D.
Program Administrator
Division of Communication Sciences and Disorders
National Institute on Deafness and Other Communication Disorders
Executive Plaza South, Suite 400B
Bethesda, MD  20892
Telephone:  (301) 402-3461

$$N3 END ************************************************************

               NOTICES OF AVAILABILITY (RFPs AND RFAs)

$$R1 BEGIN AG-93-02 FULL-TEXT ***************************************

CENTERS OF RESEARCH ON APPLIED GERONTOLOGY

NIH GUIDE, Volume 21, Number 29, August 14, 1992

RFA AVAILABLE:  AG-93-02

P.T. 04; K.W. 0710010, 0404000, 0417000

National Institute on Aging

Letter of Intent Receipt Date:  October  2, 1992
Application Receipt Date:  November 18, 1992

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

This announcement seeks to establish Centers of Research on Applied
Gerontology.  The Centers' purpose will be to facilitate the process of
translating basic behavioral and social research theories and findings
into practical outcomes that will benefit the lives of older people.
They will focus on strategies to improve quality of life, enhance
productivity, and minimize the need for care.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priorities.  This RFA, Centers
of Research on Applied Gerontology, addresses several priority areas
including chronic disabling conditions, physical activity and fitness,
violent and abusive behavior, and unintentional injuries as they relate
to older people.  Potential applicants may obtain a copy of "Healthy
People 2000" (Full Report:  Stock No. 017-001-00474-0) or "Healthy
People 2000" (Summary Report:  Stock No. 017-001-00473-1) through the
Superintendent of Documents, Government Printing Office, Washington, DC
20402-9325 (telephone 202/783-3238).

ELIGIBILITY REQUIREMENTS

Domestic public and private, for-profit and non-profit institutions and
organizations are eligible to apply in response to this RFA, provided
that some member of the proposed research team at the institution has
recently received grant or contract funds or is currently active in
research through an external peer-reviewed process in the three years
preceding the date of application.  Applications from women and
minority investigators and institutions are encouraged.  Awards will
not be made to foreign institutions.

MECHANISM OF SUPPORT

The support mechanism for these Centers will be the specialized center
(P50) mechanism.  Such awards cover a spectrum of activities that
comprise a multidisciplinary attack on a particular problem area.  A
maximum of five years of support may be requested.  At that time funds
may be available for competitive renewal of the Centers.  All current
policies and requirements that govern the research grant programs of
the NIH will apply to grants awarded in connection with this RFA.

Special Terms of Awards applying to projects funded in response to this
RFA are in addition to, and not in lieu of, otherwise applicable OMB
administrative guidelines, HHS grants administrative regulations at 45
CFR Part 74, and other HHS, PHS, and NIH grants administration
policies.  Awardees will maintain custody of and primary rights to
their data developed under their awards, subject to Government rights
of access, consistent with current HHS, PHS, and NIH policies.

FUNDS AVAILABLE

An estimated $3,000,000 will be made available in Fiscal Year 1993 for
support of awards made under this RFA.  It is expected that up to six
awards will be made at a maximum of $400,000 direct costs per award for
the first year.  This level of support is dependent on the receipt of
a sufficient number of applications of high scientific merit.  Awards
pursuant to the RFA are contingent upon the availability of funds for
this purpose.  Commitment from the applicant will be considered in
making final awards.

RESEARCH OBJECTIVES

Researchers are encouraged to seek funding to apply the theories,
paradigms, and methodology of the behavioral and social sciences in
order to address practical problems of late middle aged and older
people at work, in the home, in transportation, in health care, or in
other areas of concern to the population.  The focus of this initiative
is on translating encouraging research results obtained in laboratory
and other scientific settings into practical benefits for older adults.
The organizing principle behind each Center should reflect this aim of
establishing a pattern of research translation from basic research to
practical outcome.

The individual projects that are part of the Center should have as the
goal a practical end-point---improvement in some indicator or
indicators of functioning in these different environments.
Improvements in aspects of behavioral indicators relevant to the
practical domain (e.g., laboratory measures of cognitive functioning,
health status, or subjective well-being) may be considered interim
goals of the research strategy.  However, the end-point is improvement
in functioning in the practical domain itself. Thus the goal will not
only be confirming a theory or discovering a new effect (though these
may be expected from well-designed studies addressing practical
problems).

One highly desirable feature of the Centers will be a focus on special
populations of older people.  Growth in size of minority older
populations has been, and will continue to be, substantial.  The oldest
old remain the population at greatest risk for dependency.  Older
adults who have been identified as retarded face particular problems in
later life.  Poor older adults in rural areas have severely limited
access to health care and general services.  These and other special
populations who have pressing needs warrant attention from researchers
in aging.

SPECIAL REQUIREMENTS

Annual Meeting

Investigators are encouraged to request funds to travel once each year
to meet with the other investigators who are funded through this RFA.
The meetings will be held at the NIH, Bethesda, MD.  The purpose of the
meetings is to have investigators working in the same general area
share information about research methods and findings.  Applicants
should include a statement in the application indicating a willingness
to participate in such meetings and to cooperate with other researchers
in the exchange of data, materials, and ideas.

STUDY POPULATIONS

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDY POPULATIONS

For projects involving clinical research, the NIH requires applicants
to give special attention to the inclusion of women and minorities in
study populations. if women or minorities are not included in the study
populations for clinical studies, a specific justification for this
exclusion must be provided.  Applications without such documentation
will not be accepted for review.

LETTER OF INTENT

Prospective applicants are asked to submit, by October 2 1992, a letter
of intent that includes identification of other participating
investigators and institutions and a descriptive title.  The NIA
requests such letters only for the purpose of providing an indication
of the number and scope of applications to be received and, therefore,
usually does not acknowledge their receipt.  A letter of intent is not
binding, and it will not enter into the review of any application
subsequently submitted, nor is it a necessary requirement for
application.

The letter of intent is to be sent to Dr. Robin A. Barr at the address
under INQUIRIES.

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 9/91) is to be used
in applying for these grants.  This form is available in the applicant
institution's office of sponsored research or business office and from
the Office of Grants Inquiries, National Institutes of Health, Room
449, Westwood Building, Bethesda, MD  20892-9912, telephone (301)
496-7441.

REVIEW CONSIDERATIONS

Upon receipt, the Division of Research Grants will review applications
for completeness and NIA staff will review applications for
responsiveness.  Applications that are incomplete, nonresponsive to
this RFA, or exceed the annual direct cost limit of $400,000 (including
total costs for sub-contracts) will be returned to the applicant
without further consideration.  The NIA will withdraw from further
competition those applications judged by triage to be noncompetitive
for award and notify the applicant and institutional official.
Applications judged to be competitive will undergo further scientific
merit review by an initial review group within the NIA.  This review
may involve an applicant interview or site visit.  The second level of
review will be provided by the National Advisory Council on Aging.

The most important criterion for scientific merit review will be the
proposed Center's demonstrated potential to act as a conduit between
basic behavioral and social research and applied outcomes.  Both the
evidence of past involvement in related research and the specific plans
for seeking applied outcomes described in the application will be
considered part of that potential.  A related and important criterion
concerns the proposed Center's ability to address the needs of special
populations of older people who are identified as having particularly
pressing concerns.

INQUIRIES

Inquiries concerning this RFA are encouraged in order to clarify issues
or questions.  The RFA may be obtained from the program contact listed
below who will also answer questions on programmatic issues related to
the RFA:

Dr. Robin A. Barr
Behavioral and Social Research
National Institute on Aging
Gateway Building, Room 2C234
7201 Wisconsin Avenue
Bethesda, MD  20892
Telephone:  (301) 496-3136
FAX:  (301) 402-0051
E-mail:  Barr@NIHNIAGW.BITNET

Questions on fiscal matters should be directed to:

Ms. Linda Whipp
Grants and Contracts Management
National Institute on Aging
Gateway Building, Room 2N212
7201 Wisconsin Avenue
Bethesda, MD  20892
Telephone:  (301) 496-1472

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic
Assistance, No. 93.866.  Awards are made under the authority of the
Public Health Service Act, Section 301 (42 USC 241) and administered
under PHS grants policies and Federal Regulations, most specifically at
42 CFR Part 52 and 45 CFR Part 74.  This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review.

$$R1 END ************************************************************

$$R2 BEGIN DE-92-04 FULL-TEXT ***************************************

CLINICAL CORE CENTERS FOR PREVENTIVE AND OPERATIVE DENTISTRY

NIH GUIDE, Volume 21, Number 29, August 14, 1992

RFA AVAILABLE:  DE-92-04

P.T. 04; K.W. 0785040, 0715148, 0745027

National Institute of Dental Research

Letter of Intent Receipt Date:  October 31, 1992
Application Receipt Date:  December 3, 1992

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The National Institute of Dental Research (NIDR) invites applications
for the support of Clinical Core Centers for Preventive and Operative
Dentistry (CCCPOD).  The CCCPODs are intended to serve as focal points
to strengthen the Nation's research capability in clinical oral health
and to facilitate the development of new approaches to the prevention
and treatment of dental caries and failed restorations.  Center goals
will include:  (1) developing state-of-the-art clinical research
capacity through shared resources and facilities (core units) that
strengthen and expand relevant clinical research; (2) providing a
nucleus around which additional clinical studies funded through
government and private sources can be conducted; and (3) facilitating
and stimulating clinical research to improve oral health in children,
adults, senior citizens, and others at high risk for caries including
those with systemic diseases or oral conditions that increase the risk
for recurrent disease.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas, and to "Oral
Health 2000," a major collaborative initiative between the PHS and
professional and private research organizations to improving oral
health in the adult and elderly population groups in the U.S.A.  This
RFA, Clinical Core Centers for Preventive and Operative Dentistry, is
related to the priority area of reducing health disparities among
Americans by improving oral health.  Potential applicants may obtain a
copy of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0
or Summary Report:  Stock No. 017-001-00473-1) through the
Superintendent of Documents, Government Printing Office, Washington, DC
20402-9325 (telephone: 202-783-3238).

ELIGIBILITY REQUIREMENTS

This competition is open to domestic for-profit and non-profit
organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and
eligible agencies of the federal Government.  Foreign organizations are
not eligible to apply, however, domestic applications may include
international components.

Although an application must be submitted from a single institution, it
may include consortia arrangements with other institutions, provided
these arrangements are clearly delineated and formally and officially
confirmed by signed statements from the responsible officials of each
institution. Applicant institutions must provide clear evidence of
having a suitable clinical research base to assure appropriate
utilization of the added resources which NIDR would provide through the
CCCPOD.  This must include meritorious ongoing clinical research
projects and/or the capability to develop such clinical research,
accompanied by firm funding commitments that ensure that appropriate
clinical research projects will be active at the time of a CCCPOD
award.

MECHANISM OF SUPPORT

The CCCPODs will be supported by the National Institutes of Health
(NIH) Center Core Grants (P30).  Clinical Core Center applications
funded under this RFA will be supported for a period of five years,
commencing as early as September 1, 1993.  This RFA is for a single
competition with a receipt date of December 3, 1992.  Subsequent
support will be contingent upon program needs and availability of
funds.

In addition to support for pilot or feasibility projects, support will
be provided for core resources, the sharing of which will facilitate
the total research effort.  Each core unit must be utilized by at least
two projects. Responsibility for the planning, direction, and execution
of the proposed project will be solely that of the applicant.

FUNDS AVAILABLE

Applicants may request up to $300,000 in direct costs for the first
year.  If indirect costs are assigned to a subcontract and counted as
direct costs, the direct cost maximum of $300,000 may be exceeded by
the amount of the indirect costs assigned to the subcontract.  Budget
increases of no more than four percent per year may be requested for
each of the subsequent four years.  The NIDR expects to commit up to
$0.9 million to fund applications submitted in response to this RFA.
It is anticipated that one or two awards will be made, however, this
funding level is contingent upon the receipt of a sufficient number of
applications of high scientific merit.  Although this program is
provided for in the financial plans of the NIDR, the award of grants
pursuant to this RFA is also contingent upon the availability of funds
for this purpose.

RESEARCH OBJECTIVES

The Centers are intended to serve as focal points for strengthening the
nation's oral health clinical research capability, enhancing clinical
decision-making, and facilitating the development of new approaches for
caries diagnosis, prevention, and treatment in the light of recent
knowledge of caries etiology and pathogenesis.

The overall intent of this RFA is to attract clinical researchers and
clinicians with experience in dental materials science, molecular
biology, biochemistry, pulp biology, and clinical preventive and
operative dentistry, as well as those involved in the prevention,
diagnosis and treatment of dental caries.  The research will focus on
multi-disciplinary approaches to early diagnosis and treatment of
caries, making the distinction between caries as a disease and caries
as a lesion.  Particular emphasis is placed on the assessment of the
presence and severity of infection through identification of
microbiological and biochemical markers and prompt treatment prior to
evidence of clinical symptoms.

The research also should focus on the full range of treatments
including non-operative interventions such as the use of antibacterial
and remineralization procedures, minimal intervention such as
preventive resin restorations, and different types of other
restorations needed for the treatment of carious lesions.  Particular
attention should be paid to the development of optimal cavity
preparations for different types of restorative materials.  The
principle of cavity preparations must be based on the premise of
maintaining tooth structure to prevent the need for large restorations
and more complex sequelae.  The research should include development and
testing of maintenance and health promotion programs and studies on why
restorations fail.

Each Center must include a minimum of three core units including an
administrative core, a biostatistics core, and one or more cores
directly related to ongoing and planned oral health clinical research.
Examples of the latter core units include:  diagnostic cores to develop
methods and/or instrumentation to detect early signs or markers of oral
disease or dysfunction and to monitor the efficacy of treatments;
laboratory cores to provide resources to carry out adjunct studies on
patient or healthy populations, and unique clinical facilities to
facilitate research that cannot be carried out in conventional
health-care settings (e.g., mobile units or work-site units).

STUDY POPULATIONS

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDIES

For projects involving clinical research, the NIH requires applicants
to give special attention to the inclusion of women and minorities in
study populations.  If women or minorities are not included in the
study populations for clinical studies, a specific justification for
this exclusion must be provided.  Applications without such
documentation will not be accepted for review.

LETTER OF INTENT

Prospective applicants are asked to submit, by October 31, 1992, a
letter of intent that includes a descriptive title of the proposed
research, the name, address, and telephone number of the Principal
Investigator, the identities of other key personnel and participating
institutions, and the number and title of this RFA.  Although a letter
of intent is not required, is not binding, and does not enter into the
review of a subsequent application, the information that it contains is
helpful in planning for the timely review of applications.  It allows
Institute staff to estimate the potential review workload and to avoid
conflict of interest in review.

The letter of intent is to be addressed to Joyce A. Reese, D.D.S,
M.P.H. at the address under INQUIRIES.

APPLICATION PROCEDURES

Applications are to be prepared on form PHS 398 (rev. 9/91),
Application for PHS Grant, which may be obtained from the Office of
Grants Inquiries, Division of Research Grants, National Institutes of
Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone
301/496-7441, and from most institution's Office of Research and
Sponsored Programs.

Applications must be received by December 3, 1992.  If an application
is received after that date, it will be returned to the applicant
without review.

REVIEW CONSIDERATIONS

Applications will be evaluated by a special review committee, convened
by the NIDR Scientific Review Branch.  Prior to the initial review, a
triage mechanism may be used to screen applications that are
noncompetitive to the RFA.  Applicant interviews or site visits may not
be conducted, and the application should therefore be complete.
Secondary review will be conducted by the National Advisory Dental
Research Council.  Applications must be received by December 3, 1992,
so they can be reviewed and considered for funding in Fiscal Year 1993.
Applications judged to be noncompetitive or nonresponsive to the RFA,
and those received after December 3, 1992 or exceeding the budget
limitation will be returned without review.  Waivers of the receipt
deadline and budget limitation will not be granted.

INQUIRIES

Written and telephone request for the RFA and an opportunity to clarify
any issues or questions from potential applicants are welcome.

Direct request for the RFA and inquiries regarding programmatic issues
to:

Joyce A. Reese, D.D.S, M.P.H.
Director, Biomaterials, Pulp Biology and Dental Implants Program
National Institute of Dental Research
Westwood Building, Room 505
Bethesda, MD  20892-4500
Telephone:  (301) 496-7884
FAX:  (301) 496-4180

Direct inquiries regarding fiscal matters to:

Ms. Theresa Ringler
Chief, Grants Management Section
National Institute of Dental Research
Westwood Building, Room 518
Bethesda, MD  20892
Telephone:  (301) 496-7437
FAX:  (301) 402-1260

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.1212.  Awards will be made under authorization of the Public
Health Service Act, Title IV, Part A  (Public Law 78-410, as amended by
Public Law 99-158, 42 USC 241 and 285) and administered under PHS
grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part
74.  This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.

$$R2 END ************************************************************

$$R3 BEGIN GM-92-003 ************************************************

SUPPLEMENTS FOR UNDERGRADUATE RESEARCH EXPERIENCE PROGRAM

NIH GUIDE, Volume 21, Number 29, August 14, 1992

P.T. 34; K.W. 0720005, 0710030

RFA:  GM-92-003

National Institute of General Medical Sciences

Application Receipt Date:  November 6, 1992

PURPOSE

The National Institute of General Medical Sciences (NIGMS) announces a
pilot program, the Supplements for Undergraduate Research Experience
(SURE) Program, to provide supplements to NIGMS grants to enable
Principal Investigators (PI) to support undergraduate students for a
10-week summer research experience in their laboratories.  The purpose
of the program is to attract talented students to careers in the
biomedical sciences by giving them a hands-on research experience at a
critical point in their academic careers.

ELIGIBILITY REQUIREMENTS

PIs at domestic institutions who hold an active Research Project (R01),
First Independent Research Support and Transition (FIRST) (R29), Method
to Extend Research in Time (MERIT) (R37), Program Project (P01), or
Center (P50) grant from the NIGMS are eligible to submit a request for
an administrative supplement.  Recipients of Academic Research
Enhancement Awards (AREA) (R15) and Small Business Innovative Research
(SBIR) (R43 and R44) grants are not eligible, nor are PIs at foreign
institutions.  In all cases, the parent grant must have support
remaining through the period of the proposed SURE award.

It is expected that each parent grant, including Program Projects and
Centers, will support only one undergraduate student through this
program.  Award of an administrative supplement to support a minority
undergraduate student under the Research Supplements for
Underrepresented Minorities program or a disabled undergraduate student
under the program of Research Supplements to Promote the Recruitment of
Individuals with Disabilities into Biomedical Research Careers in no
way precludes an award to the PI through the SURE Program.

MECHANISM OF SUPPORT

Support will be provided through supplements made to active R01, R29,
R37, P01, and P50 grants funded by the NIGMS.  This RFA is a one-time
solicitation.

Successful applicants for supplements will be notified in February 1993
in order to provide sufficient time to recruit talented students.  The
supplement is not to exceed $6.00 per hour for salary plus $125 per
month for supplies for a period of 10 weeks.  Equipment may not be
purchased from these funds.  Applicable indirect costs will be
provided.  Supplemental funds will be restricted to the purpose
described in this announcement.  Recipients of supplements must submit
appointment forms (PHS 2271) to the NIGMS.  Students who are supported
by SURE awards will be designated "NIGMS Summer Scholars" and will
receive certificates at the completion of their research experience.

FUNDS AVAILABLE

It is estimated that the NIGMS will award up to 250 SURE awards.  This
level of support is dependent on the receipt of a sufficient number of
applications of high merit.  Although this program is provided for in
the financial plans of the NIGMS, awards pursuant to this RFA are
contingent upon the availability of funds for this purpose.

RESEARCH OBJECTIVES

The NIGMS is strongly committed to supporting research training in the
biomedical sciences through its institutional training grants and
individual fellowships awarded under the National Research Service
Award (NRSA) Act.  The NIGMS recognizes that to maintain the success of
its training programs, talented undergraduate students must continue to
be attracted to the biological sciences and related areas, such as
chemistry, physics, and mathematics.  Often, however, promising
undergraduates, particularly at large, research-intensive universities,
are deterred from pursuing science majors because of a lack of
opportunity for personal participation in research at a critical stage
in their academic careers.

The SURE Program will make administrative supplements to NIGMS research
grants to enable PIs to provide support for undergraduate students who
participate in research in their laboratories for the summer.
Supplements will be awarded for support during the summer of 1993, and
it is hoped that institutional and other sources of support will enable
interested students to continue the research experience beyond the
initial summer.

Supplements to NIGMS research grants are designed to provide beginning
undergraduate students who have not yet begun their junior year with a
summer research experience.  The proposed research must be an integral
part of the approved ongoing research supported by the parent grant.
As part of this research experience, the student must be given the
opportunity to interact with scientists and graduate students in the
laboratory, to contribute intellectually to the research, and to
enhance research skills and knowledge in the particular area of
biomedical science.  In addition, the PI must demonstrate an ability
and a willingness to serve as a supportive mentor and a role model in
encouraging interest in a career in biomedical research.  Although it
is understood that other members of the laboratory will be involved in
the student's training, it is expected that the PI will be responsible
for serving as the primary mentor.  In particular, it is expected that
the PI will discuss with the student the ongoing  research in the
laboratory and its broader scientific context, appropriate laboratory
practices and scientific conduct, appropriate use of human subjects and
animals, if applicable, and career options.  Supplemental awards will
be consistent with the goal of strengthening the existing research
program.  Awards will be made according to the policies and provisions
stated in this announcement.

Students are expected to devote an equivalent of 10 weeks of full-time
effort to the research project.

SPECIAL REQUIREMENTS

By acceptance of a supplement, the PI agrees to provide the NIGMS, as
part of the next progress report (non-competing, competing, or final),
with an evaluation of the student's accomplishments during the program.
In addition, the PI is responsible for ensuring that the student submit
a one to two page report which should include both a description of the
research project and results obtained and an evaluation of the research
experience and an assessment of its impact on career goals.  This
report should be submitted to the NIGMS no later than September 15,
1993.

APPLICATION PROCEDURES

All requests for supplements must be received by November 6, 1992.  In
making requests, the grantee institution, on behalf of the PI of the
parent grant, must submit four copies of the application, including a
signed original, directly to:

Office of the Associate Director for Program Activities
National Institute of General Medical Sciences
Westwood Building, Room 940
5333 Westbard Avenue
Bethesda, MD  20892

The request for a SURE award must include the following:

o  A completed face page (with appropriate signatures) from grant
application form PHS 398 (rev. 9/91).  This form is available at most
institutional business offices and from the Office of Grants Inquiries,
Division of Research Grants, National Institutes of Health, 5333
Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301)
496-7441.  Include on line 1 the title and grant number of the parent
grant and specify on line 2a (Response to Specific Request for
Applications or Program Announcement) "Supplement for Undergraduate
Research Experience."

o  A brief description (maximum of three pages), prepared by the PI of
the parent grant, that includes:

(a) the PIs plans for mentoring, training, and advising the student.
It is NOT necessary to have identified a student for support at the
time of submission of the request, but, if a student has not been
identified, some indication should be given of the plans to recruit,
the criteria for selection of a student, and the likelihood of success;

(b) plans for the student's research experience and a discussion of the
student's role in relation to the research supported by the parent
grant;

(c) expectations for how the research experience will foster the
research capabilities and scientific interests of the student;

(d) a proposed budget entered on the budget pages from the grant
application form PHS 398; and

(e) documentation, if applicable, that the proposed research experience
was approved by the Institutional Animal Care and Use Committee (IACUC)
or the Human Subjects Review Board (IRB) of the grantee institution.

REVIEW CONSIDERATIONS

The staff of the NIGMS will review requests for supplements using the
following general criteria:

o  Adequacy of the plan for the proposed research experience of the
student;
o  Evidence that the experience will enhance the research potential,
knowledge, and/or skills of the undergraduate and his/her interest in
biomedical science;
o  Evidence that the activities of the student will be an integral part
of the project;
o  The suitability of the research environment; and
o  The commitment of the PI and the grantee institution to promote and
support undergraduate research.  A strong indication of the PIs
commitment is a demonstration of past mentorship of undergraduates.

AWARD CRITERIA

It is hoped that many of the students supported under the SURE Program
will be able to continue their research experiences beyond the 10-week
period with institutional support.  A commitment of this sort from the
PI and the grantee institution would be viewed favorably in making
awards.

INQUIRIES

Principal Investigators interested in applying for this program may
contact the program administrator whose name appears on the Notice of
Grant Award or:

Michael Martin, Ph.D.
Deputy Associate Director, Office of Program Activities
National Institute of General Medical Sciences
Westwood Building, Room 938
Bethesda, MD  20892
Telephone:  (301) 496-7063

Inquiries regarding fiscal matters are to be directed to the grants
management specialist whose name appears on the Notice of Grant Award
or:

Ms. Ruth Monaghan
Deputy Grants Management Officer
National Institute of General Medical Sciences
Westwood Building, Room 953
Bethesda, MD  20892
Telephone:  (301) 496-7746

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.821, 93.859, 93.862, 93.863.  Awards are made under
authorization of the Public Health Service Act, Title IV, Part A
(Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and
285) and administered under PHS grants policies and Federal Regulations
42 CFR 52 and 45 CFR Part 74.  This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review.

$$R3 END ************************************************************

                    ONGOING PROGRAM ANNOUNCEMENTS

$$P1 BEGIN PA-92-96 *************************************************

RESEARCH CAREER DEVELOPMENT IN MYCOBACTERIUM TUBERCULOSIS

NIH GUIDE, Volume 21, Number 29, August 14, 1992

PA NUMBER:  PA-92-96

P.T. 34; K.W. 0715125, 0715165, 1002008, 0710070, 0740075, 0745020

National Institute of Allergy and Infectious Diseases

PURPOSE

The Department of Health and Human Services (DHHS) National Action Plan
to Combat Multidrug-Resistant Tuberculosis (April 1992) has listed the
training of tuberculosis researchers as a high priority item necessary
to achieve tuberculosis control.  Individuals trained as
physician-investigators and basic scientists are essential to expansion
of high quality research programs in the area of tuberculosis.  There
is an urgent need to promote research training in basic and clinical
aspects of tuberculosis including improved diagnosis, molecular
biology, therapeutics, patient compliance, immunology, and vaccine
development.  Many laboratory techniques for the diagnosis of
tuberculosis and for the identification of drug resistance were
developed in the 1950s and 1960s.  Although more accurate, rapid, and
sophisticated methods are available, they have not been implemented for
tuberculosis.  The increasing incidence of both tuberculosis and drug-
resistant tuberculosis makes it imperative to apply current
technologies to the fullest capacity.

This Program Announcement (PA) emphasizes the commitment of the
National Institute of Allergy and Infectious Diseases (NIAID) to
support Clinical Investigator Awards (K08), Physician Scientist Awards
(K11), and Research Career Development Awards (K04) to increase the
number of biomedical investigators conducting high-quality research in
the area of Mycobacterium tuberculosis (Mtb).  The NIAID encourages
eligible individuals, including underrepresented minorities and women,
to submit applications.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Research Career Development in Mycobacterium Tuberculosis, is related
to the priority areas of immunization and infectious diseases, and HIV
infection.  Potential applicants may obtain a copy of "Healthy People
2000" (Full Report:  Stock No. 017-001-00474-0) or "Healthy People
2000" (Summary Report:  Stock No. 017-001-00473-1) through the
Superintendent of Documents, Government Printing Office, Washington, DC
20402-9935 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

The PSA-K11 award is designed to encourage newly trained clinicians to
develop independent research skills and experience in a fundamental
science.  Applicants for the PSA must hold an M.D. or other health
professional degree.  Ordinarily, candidates holding both a medical
degree and a Ph.D. degree in the biomedical sciences are ineligible.

The CIA-K08 award seeks to provide clinically trained individuals with
demonstrated aptitude in research to develop into independent
investigators.  Applicants for the K08 award must hold an M.D. or other
health professional degree, have had three to five years of clinical
and research postdoctoral experience by the projected start of the
award and not have been a Principal Investigator on a Public Health
Service-supported research project grant (R01, R29, R15).

The RCDA-K04 award is designed to foster the development of young
scientists with outstanding research potential for careers of
independent research in health related sciences. The salary support
provided is intended to allow release time from most of the teaching,
clinical, and administrative duties to permit nearly full time
involvement in research efforts.  Applicants for the RCDA must hold a
doctoral degree or equivalent and have at least five years postdoctoral
research experience which can include two years as the Principal
Investigator of a peer reviewed research grant, prior to the requested
beginning date of the award.

MECHANISMS OF SUPPORT

Each of the career development mechanisms is tailored to a particular
stage of an investigator's career.  Existing mechanisms supported by
the NIAID include:  the Physician Scientist Award (PSA-K11), the
Clinical Investigator Award (CIA-K08), and the Research Career
Development Award (RCDA-K04).  Physician investigators are encouraged
to use the PSA and CIA to develop expertise in basic and clinical
research.  Only U.S. citizens or non-citizens lawfully admitted for
permanent residence at the time of application are eligible to apply.
The distinguishing features of each of the "K" mechanisms are
summarized above.  The booklet, The K Awards, is available from the
Office of Grants Inquiries, Division of Research Grants, National
Institutes of Health, Westwood Building, Room 449, Bethesda, MD  20892-
9912, (telephone: (301) 496-7441).

SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH
POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDY POPULATIONS

NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical
research grants and cooperative agreements will be required to include
minorities and women in study populations so that research findings can
be of benefit to all persons at risk of the disease, disorder or
condition under study; special emphasis should be placed on the need
for inclusion of minorities and women in studies of diseases, disorders
and conditions which disproportionately affect them.  This policy is
intended to apply to males and females of all ages.  If women or
minorities are excluded or inadequately represented in clinical
research, particularly in proposed population-based studies, a clear
compelling rationale should be provided.

The composition of the proposed study population must be described in
terms of gender and racial/ethnic group.  In addition, gender and
racial/ethnic issues should be addressed in developing a research
design and sample size appropriate for the scientific objectives of the
study.  This information should be included in the form PHS 398 in
Sections 1-4 of the Research Plan AND summarized in Section 5, Human
Subjects.  Applicants are urged to assess carefully the feasibility of
including the broadest possible representation of minority groups.
However, the NIH recognizes that it may not be feasible or appropriate
in all research projects to include representation of the full array of
United States racial/ethnic minority populations (i.e., Native
Americans (including American Indians or Alaskan Natives),
Asian/Pacific Islanders, Blacks, Hispanics).

The rationale for studies on single minority population groups should
be provided.

For the purpose of this policy, clinical research includes human
biomedical and behavioral studies of etiology, epidemiology, prevention
(and preventive strategies), diagnosis, or treatment of diseases,
disorders or conditions, including but not limited to clinical trials.

The usual NIH policies concerning research on human subjects also
apply.  Basic research or clinical studies in which human tissues
cannot be identified or linked to individuals are excluded.  However,
every effort should be made to include human tissues from women and
racial/ethnic minorities when it is important to apply the results of
the study broadly, and this should be addressed by applicants.

If the required information is not contained within the application,
the application will be returned.

Peer reviewers will address specifically whether the research plan in
the application conforms to these policies. If the representation of
women or minorities in a study design is inadequate to answer the
scientific question(s) addressed AND the justification for the selected
study population is inadequate, it will be considered a scientific
weakness or deficiency in the study design and will be reflected in
assigning the priority score to the application.  All applications for
clinical research submitted to NIH are required to address these
policies. NIH funding components will not award grants or cooperative
agreements that do not comply with these policies.

RESEARCH OBJECTIVES

Studies that are encouraged include, but are not limited to, the
following research areas:

o  Basic Biology:  Studies on the growth, physiology, biochemistry,
genetics, and molecular biology of Mtb.

o  Pathogenesis:  Clinical and basic research on the pathogenesis of
Mtb including physiology, biochemistry, and structural biology;
identification and characterization of virulence factors; genetic
exchange, and the development of physical and genetic maps; mechanisms
of drug resistance; role of cytokines in disease progression; and the
mechanism of latency and reactivation of infection, especially
characterization of the cellular and molecular components of the
immune-mediated mechanisms involved in the development of active and
latent disease and in protection.

o  Improved Diagnostic Procedures:  Development and evaluation of new
technologies to rapidly and reliably diagnose tuberculosis and identify
drug susceptibility patterns.  Research in further innovation and
application of diagnostic tests to distinguish between active and
latent tuberculosis in patients with compromised immune systems.

o  Drug Discovery and Development:  Development of new in vitro assays,
culture systems, and animal models to assess the safety and efficacy of
potential compounds to treat tuberculosis.  Research in the development
and evaluation of new drugs and modalities to treat and prevent
multi-drug resistant tuberculosis.  Research to reduce the duration of
therapy required to treat drug-susceptible infections. Research on
timed controlled-release drugs and the administration or means to
increase compliance with therapy.

o  Vaccine Development:  New and improved vaccines to prevent Mtb
infection.  Development of novel vaccine vectors.  Research on the
regulation of responses by immunomodulators and identification of the
antigens involved in protection.  Development of animal models to
correlate immune responses with protection.

APPLICATION PROCEDURES

Application receipt dates for all competing career development awards
(K series) are February 1, June 1, and October 1.  Institute assignment
decisions will be governed by the program considerations as specified
in the PHS Referral Guidelines.  Earliest possible funding dates are
approximately ten months after the receipt dates.  The special
instructions for the PSA and CIA are found in the publication entitled
"The K Awards," revised October 1991.  Application form PHS 398 (rev.
9/91) and "The K Awards" are available from the Office of Grants
Inquires, Division of Research Grants, National Institutes of Health,
Westwood Building, Room 449, Bethesda, MD  20892-9912.  Applications
submitted in response to this program announcement must be identified
by typing "PA-92-96, Research Career Development In Mycobacterium
Tuberculosis" on line 2a of the face page of the PHS 398 form that is
available from the applicant institution's office of sponsored research
and from the Office of Grants Inquiries, National Institutes of Health,
Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/496-
7441.

Applicants from institutions that have a General Clinical Research
Center (GCRC) funded by the NIH National Center for Research Resources
may wish to identify the GCRC as a resource for conducting the proposed
activity.  In such a case, a letter of agreement from either the GCRC
program director or Principal Investigator must be included with the
application.

REVIEW CONSIDERATIONS

Applications in response to this announcement will receive initial peer
review on the basis of standard NIH review criteria and guidelines.
Applications for the Clinical Investigator Award (K08) and the
Physician Scientist Award (K11) will be reviewed for scientific merit
by scientific review groups (SRGs) convened by the concerned institute.
Applications for Research Career Development Awards (K04) will be
reviewed for scientific merit by initial review group(s) (IRGs)
convened by the Division of Research Grants, NIH.  Applicants are
referred to the NIH brochure, The K Awards (October 1991 edition),
which details the qualifications, eligibility, etc., for the K08, K11,
and K04 candidates, as well as the review criteria.  This brochure
should be available at the institution's business office, or a copy may
be requested from the Grants Inquiries Office, Division of research
Grants, National Institutes of Health, Bethesda, MD 20892, telephone
(301) 496-7441.  Award criteria will be the overall merit of the
application as determined by the IRG, relevance of the application to
the research objectives as outlined in this PA, and availability of
funds.

AWARD CRITERIA

The award of grants pursuant to this announcement is contingent upon
availability of appropriated funds.  The following criteria will be
used in making funding decisions: overall merit of the proposed project
as determined by peer review, availability of funds, relevance to the
research priorities of the awarding institute, and program balance
among research areas of the announcement.

INQUIRIES

For further information about NIAID career development awards, contact:

Dr. Milton J. Hernandez
Director, Office of Science Training and Manpower Development
National Institute of Allergy and Infectious Diseases
Solar Building 4C-10
6003 Executive Blvd.
Bethesda, MD  20892
Telephone:  (301) 496-7291

For inquiries regarding fiscal and business matters, contact:

Ms. Barbara A. Huffman
Special Assistant for Operations
Grants Management Branch
Director of Extramural Affairs
National Institute of Allergy and Infectious Diseases
Solar Building 4C-26
6003 Executive Blvd.
Bethesda, MD  20892
Telephone:  (301) 496-7075

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.855, Allergy, Immunology and Transplantation Research, and No.
93.856, Microbiology and Infectious Diseases Research.  Awards will be
made under the authority of the Public Health Service Act, Title III,
Section 301 (Public Law 78-410, as amended; 42 USC 241) and
administered under PHS grants policies and Federal Regulations 42 CFR
Part 74.  This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.

$$P1 END ************************************************************

$$P2 BEGIN PA-92-97 *************************************************

DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

NIH GUIDE, Volume 21, Number 29, August 14, 1992

PA NUMBER:  PA-92-97

P.T. 34; K.W. 1002002

National Center for Research Resources

Application Receipt Date:  October 1, 1992

PURPOSE

The National Center for Research Resources (NCRR) assists institutions
in developing, modernizing, and improving animal resources for
biomedical research and research training by awarding research and
resource grants.  Animal resource improvement grants (G20) are awarded
for this purpose and to assist institutions in complying with the
provisions of the Animal Welfare Act and Public Health Service (PHS)
policies related to the care and use of laboratory animals.  Requests
are limited to alterations and renovations (A&R) and to purchases of
major animal resource equipment (with a unit value of at least $1,000).
Support for new construction, including completion of shell space, is
not authorized.  Projects may address improvement of animal facilities
and related activities, including centralized experimental surgical
facilities, diagnostic laboratories, and transgenic animal resources.

ELIGIBILITY REQUIREMENTS

Any domestic public or private institution, organization, or
association with one or more research projects supported by the PHS
that involve the use of laboratory animals is eligible to apply.
Institutions and commercial firms providing only services or products
and without a clearly defined animal related research component are not
eligible to apply.  Also, this program will not support requests for
equipment used for teaching purposes and for housing non-research
animals.  Applicants may not submit more than one application or apply
for other NCRR support for developing and improving institutional
animal resources in the same Federal fiscal year.

There is a separate program and guidelines for animal facility
improvement grant applications from small research institutions
receiving less than $1,000,000 (direct costs) of PHS support for
research projects during the most recently completed Federal fiscal
year (refer to PA-92-10 that was published in the NIH Guide for Grants
and Contracts, Vol. 20, No. 39, October 18, 1991).

MECHANISM OF SUPPORT

The mechanism available for the support of improvement projects is the
Grant for Repair, Renovation, and Modernization of Existing Research
Facilities (G20).  Requests are limited to A&R to improve existing
laboratory animal facilities, allowable fees associated with the A&R
project, and major resource equipment related to the improvement
project, such as animal cage systems and cage washers.  Equipment
requests must have a manufacturer's unit value of at least $1,000.
Requests for basic general purpose equipment items for centralized
surgeries, diagnostic laboratories, transgenic animal facilities, and
other similar associated activities are allowable when well justified
and integral to the proposed project.  The total budget request for the
improvement grant application and award is limited to a total of
$700,000 (direct costs), of which not more than $500,000 may be used
for alterations and renovations.  Matching funds from non-Federal
sources, equal to or exceeding one-half of the total award ($2 Federal
to $1 non-Federal), are required.

RESEARCH OBJECTIVES

Animal resource improvement grants are awarded to assist biomedical
research institutions in upgrading animal facilities and developing
administratively centralized and uniformly effective programs of animal
care.  Another major objective is to assist institutions in complying,
and maintaining compliance, with provisions of the Animal Welfare Act
and PHS policies related to the care and use of laboratory animals.

APPLICATION PROCEDURES

Applications are to be submitted on form PHS 398, "Application for
Public Health Service Grant," (rev. 9/91) to the NIH Division of
Research Grants.  The single annual receipt date for applications in
response to this announcement is October 1.  Applications received by
this deadline will receive February/March initial peer review, May/June
review by the National Advisory Research Resources Council, and will
have an earliest possible award date of July 1.  Applications received
after the October 1 deadline will be returned to the applicant without
review.

The completed original application (signed original including
appendices, if any) and three copies must be sent or delivered to:

Grant Application Receipt Office
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892-4500**

Simultaneously, two additional copies (with appendices, if any) must be
sent under separate cover to:

Scientific Review Administrator
Comparative Medicine Review Committee
Office of Review
National Center for Research Resources
Westwood Building, Room 10A16
Bethesda, MD  20892-4500**

Application forms (PHS 398) may be obtained from grantee business or
sponsored projects offices and from the Office of Grants Inquiries,
Division of Research Grants, National Institutes of Health, Westwood
Building, Room 449, 5333 Westbard Avenue, Bethesda, MD 20892-4500,
telephone: (301) 496-7441.

REVIEW CONSIDERATIONS

All applications will be reviewed for scientific and technical merit by
an appropriate review committee managed by the Office of Review, NCRR.
Second level review will be provided by the National Advisory Research
Resources Council.  Review of the applications will be based on
scientific merit, technical soundness, and cost effectiveness.

AWARD CRITERIA

Applications will compete for available funds with all other
applications assigned to the Comparative Medicine Program, NCRR.  The
following will be considered when making funding decisions:

o  Quality of the proposed project as determined by peer review
o  Institutional assurance of non-federal matching funds
o  Availability of funds

INQUIRIES

Inquiries about specific improvement program guidelines and detailed
instructions for application and other aspects of the program are
encouraged and are to be directed to the following address (requests
for guidelines must include two self-addressed mailing labels):

Director, Laboratory Animal Science Program
Comparative Medicine Program
National Center for Research Resources
Westwood Building, Room 857
5333 Westbard Avenue
Bethesda, MD  20892-4500
Telephone:  (301) 496-5175
FAX:  (301) 480-0868

Questions regarding fiscal matters are to be directed to:

Mr. Paul Karadbil
Supervisory Grants Management Specialist
Office of Grants and Contracts Management
National Center for Research Resources
Westwood Building, Room 849
Bethesda, MD  20892-4500
Telephone:  (301) 496-9840

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.306, Laboratory Animal Sciences and Primate Research.  Awards
will be made under the authority of the Public Health Service Act,
Title III, Section 301 (Public Law 78.410, as amended; 42 USC 241) and
administered under PHS grants policies and Federal Regulations 42 CFR
Part 52 and 45 CFR Part 74.  This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review.

$$P2 END ************************************************************

$$P3 BEGIN PA-92-98 *************************************************

SCIENTIST DEVELOPMENT AWARD FOR CLINICIANS

NIH GUIDE, Volume 21, Number 29, August 14, 1992

PA AVAILABLE:  PA-92-98

P.T. 34; K.W. 0404003, 0404009, 0715129, 0785035

National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institute of Mental Health

Application Receipt Dates:  February 1, June 1, October 1

THE PROGRAM ANNOUNCEMENT (PA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE PA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The National Institute on Alcohol Abuse and Alcoholism, the National
Institute on Drug Abuse, and the National Institute of Mental Health
provide Scientist Development Awards for Clinicians to eligible
applicants early in their careers who need additional supervised
research experience to develop into independent scientists.  These
awards are intended to make it possible for investigators to engage in
alcohol, drug abuse, and/or mental health related research on a
full-time, long-term basis, and to stimulate recipient institutions to
maintain and expand existing research programs or to establish new ones
for studies in these areas.

Each funding component has different program goals and initiatives;
therefore, potential applicants must contact the appropriate Institute
office, listed below, prior to preparing an application to obtain the
full Program Announcement (PA) and current information with regard to
the Scientist Development Award.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Scientist Development Award For Clinicians, is related to the priority
areas of mental health and disorders and alcohol and other drugs.
Potential applicants may obtain a copy of "Healthy People 2000" (Full
Report:  Stock No. 017-001-00474-0 or Summary Report:  Stock No. 017-
001-00473-1) through the Superintendent of Documents, Government
Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Eligible applicant institutions include public and private, non-profit
and for-profit organizations and institutions engaged in alcohol, drug
abuse, and/or mental health research that are located in the United
States or its territories and possessions.  These institutions apply on
behalf of a qualified candidate who holds an earned doctorate.  Women
and minority candidates in particular are encouraged to apply.

An individual who has been a Principal Investigator on a Public Health
Service (PHS) research grant or who has had equivalent research support
is not eligible for this award.  Recipients of PHS Small Grant Awards
are an exception to this restriction and are eligible to apply.
Persons who hold a position with firm salary support for full time
research, or those with endowed chairs, are not eligible.

MECHANISM OF SUPPORT

The mechanism of support is the Scientist Development Award for
Clinicians (K20), which is intended for persons trained primarily as
clinicians who show great promise for becoming researchers, but need
supervised research experience to develop into independent
investigators.

The essential elements of the K20 are the qualifications and potential
of the candidate, an individualized, well thought-out career
development and research plan, a dedicated, capable preceptor, and
commitment on the part of the applicant institution to the development
of the candidate. Documentation concerning each of these essential
elements must be included in the K20 application.

The candidate must be a citizen or noncitizen national of the United
States, or must have been lawfully admitted to the United States for
permanent residence and must possess an Alien Registration Receipt Card
(Form I-151 or I-551) at the time of an award.  The candidate must have
had no more than three years of research training or experience in the
aggregate and must have had at least two years of postdoctoral clinical
training or experience by the time the award is made.

Period of Support:  The K20 is limited to a single period of five
years.

Salary Support:  The salary proposed must be consistent with the
established salary structure for full-time, 12-month appointments at