From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human membrane glycoprotein gp130 mRNA, complete cds.
Date: 29 Jul 92 10:02:26 GMT
Distribution: bionet
Checksum: 52894     7

LOCUS       HUMIL6GP     3085 bp ss-mRNA            PRI       29-JUL-1992
DEFINITION  Human membrane glycoprotein gp130 mRNA, complete cds.
ACCESSION   M57230
KEYWORDS    interleukin 6; interleukin 6 receptor;
            interleukin 6 signal transducer; membrane glycoprotein.
SOURCE      Human placenta and myeloma cell line (U266), cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3085)
  AUTHORS   Hibi,M., Murakami,M., Saito,M., Hirano,T., Taga,T. and Kishimoto,T.
  TITLE     Molecular cloning and expression of an IL-6 signal transducer,
            gp130
  JOURNAL   Cell 63, 1149-1157 (1990)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     sig_peptide     256..321
                     /gene="gp130"
                     /note="putative"
                     /codon_start=1
     CDS             256..3012
                     /product="membrane glycoprotein 130"
                     /gene="IL6"
                     /note="putative"
                     /codon_start=1
                     /translation="MLTLQTWVVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNF
                     TAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLT
                     CNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTL
                     KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVY
                     KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPED
                     TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY
                     KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLT
                     NDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV
                     KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPE
                     SIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET
                     AVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVP
                     VCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQM
                     YSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPS
                     ISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQL
                     VDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHI
                     SQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGG
                     YMPQ"
     mat_peptide     322..3009
                     /product="membrane glycoprotein 130"
                     /gene="gp130"
                     /note="putative"
                     /codon_start=1
BASE COUNT      977 a    637 c    656 g    815 t
ORIGIN
        1 gagcagccaa aaggcccgcg gagtcgcgct gggccgcccc ggcgcagctg aaccgggggc
       61 cgcgcctgcc aggccgacgg gtctggccca gcctggcgcc aaggggttcg tgcgctgtgg
      121 agacgcggag ggtcgaggcg gcgcggcctg agtgaaaccc aatggaaaaa gcatgacatt
      181 tagaagtaga agacttagct tcaaatccct actccttcac ttactaattt tgtgatttgg
      241 aaatatccgc gcaagatgtt gacgttgcag acttgggtag tgcaagcctt gtttattttc
      301 ctcaccactg aatctacagg tgaacttcta gatccatgtg gttatatcag tcctgaatct
      361 ccagttgtac aacttcattc taatttcact gcagtttgtg tgctaaagga aaaatgtatg
      421 gattattttc atgtaaatgc taattacatt gtctggaaaa caaaccattt tactattcct
      481 aaggagcaat atactatcat aaacagaaca gcatccagtg tcacctttac agatatagct
      541 tcattaaata ttcagctcac ttgcaacatt cttacattcg gacagcttga acagaatgtt
      601 tatggaatca caataatttc aggcttgcct ccagaaaaac ctaaaaattt gagttgcatt
      661 gtgaacgagg ggaagaaaat gaggtgtgag tgggatggtg gaagggaaac acacttggag
      721 acaaacttca ctttaaaatc tgaatgggca acacacaagt ttgctgattg caaagcaaaa
      781 cgtgacaccc ccacctcatg cactgttgat tattctactg tgtattttgt caacattgaa
      841 gtctgggtag aagcagagaa tgcccttggg aaggttacat cagatcatat caattttgat
      901 cctgtatata aagtgaagcc caatccgcca cataatttat cagtgatcaa ctcagaggaa
      961 ctgtctagta tcttaaaatt gacatggacc aacccaagta ttaagagtgt tataatacta
     1021 aaatataaca ttcaatatag gaccaaagat gcctcaactt ggagccagat tcctcctgaa
     1081 gacacagcat ccacccgatc ttcattcact gtccaagacc ttaaaccttt tacagaatat
     1141 gtgtttagga ttcgctgtat gaaggaagat ggtaagggat actggagtga ctggagtgaa
     1201 gaagcaagtg ggatcaccta tgaagataga ccatctaaag caccaagttt ctggtataaa
     1261 atagatccat cccatactca aggctacaga actgtacaac tcgtgtggaa gacattgcct
     1321 ccttttgaag ccaatggaaa aatcttggat tatgaagtga ctctcacaag atggaaatca
     1381 catttacaaa attacacagt taatgccaca aaactgacag taaatctcac aaatgatcgc
     1441 tatctagcaa ccctaacagt aagaaatctt gttggcaaat cagatgcagc tgttttaact
     1501 atccctgcct gtgactttca agctactcac cctgtaatgg atcttaaagc attccccaaa
     1561 gataacatgc tttgggtgga atggactact ccaagggaat ctgtaaagaa atatatactt
     1621 gagtggtgtg tgttatcaga taaagcaccc tgtatcacag actggcaaca agaagatggt
     1681 accgtgcatc gcacctattt aagagggaac ttagcagaga gcaaatgcta tttgataaca
     1741 gttactccag tatatgctga tggaccagga agccctgaat ccataaaggc ataccttaaa
     1801 caagctccac cttccaaagg acctactgtt cggacaaaaa aagtagggaa aaacgaagct
     1861 gtcttagagt gggaccaact tcctgttgat gttcagaatg gatttatcag aaattatact
     1921 atattttata gaaccatcat tggaaatgaa actgctgtga atgtggattc ttcccacaca
     1981 gaatatacat tgtcctcttt gactagtgac acattgtaca tggtacgaat ggcagcatac
     2041 acagatgaag gtgggaagga tggtccagaa ttcactttta ctaccccaaa gtttgctcaa
     2101 ggagaaattg aagccatagt cgtgcctgtt tgcttagcat tcctattgac aactcttctg
     2161 ggagtgctgt tctgctttaa taagcgagac ctaattaaaa aacacatctg gcctaatgtt
     2221 ccagatcctt caaagagtca tattgcccag tggtcacctc acactcctcc aaggcacaat
     2281 tttaattcaa aagatcaaat gtattcagat ggcaatttca ctgatgtaag tgttgtggaa
     2341 atagaagcaa atgacaaaaa gccttttcca gaagatctga aatcattgga cctgttcaaa
     2401 aaggaaaaaa ttaatactga aggacacagc agtggtattg gggggtcttc atgcatgtca
     2461 tcttctaggc caagcatttc tagcagtgat gaaaatgaat cttcacaaaa cacttcgagc
     2521 actgtccagt attctaccgt ggtacacagt ggctacagac accaagttcc gtcagtccaa
     2581 gtcttctcaa gatccgagtc tacccagccc ttgttagatt cagaggagcg gccagaagat
     2641 ctacaattag tagatcatgt agatggcggt gatggtattt tgcccaggca acagtacttc
     2701 aaacagaact gcagtcagca tgaatccagt ccagatattt cacattttga aaggtcaaag
     2761 caagtttcat cagtcaatga ggaagatttt gttagactta aacagcagat ttcagatcat
     2821 atttcacaat cctgtggatc tgggcaaatg aaaatgtttc aggaagtttc tgcagcagat
     2881 gcttttggtc caggtactga gggacaagta gaaagatttg aaacagttgg catggaggct
     2941 gcgactgatg aaggcatgcc taaaagttac ttaccacaga ctgtacggca aggcggctac
     3001 atgcctcagt gaaggactag tagttcctgc tacaacttca gcagtaccta taaagtaaag
     3061 ctaaaatgat tttatctgtg aattc
//