From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rat fatty acid synthase gene, complete cds.
Date: 29 Jul 92 10:03:42 GMT
Distribution: bionet
Checksum: 64428    35

LOCUS       RATFASYN    18171 bp ds-DNA             ROD       29-JUL-1992
DEFINITION  Rat fatty acid synthase gene, complete cds.
ACCESSION   M84761
KEYWORDS    fatty acid synthase.
SOURCE      Rattus norvegicus (strain Sprague-Dawley) (library: T. Sargent and
            J. Bonner) adult DNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (sites)
  AUTHORS   Amy,C.M., Witkowski,A., Naggert,J., Williams,B., Randhawa,Z. and
            Smith,S.
  TITLE     Molecular cloning and sequencing of cDNAs encoding the entire rat
            fatty acid synthase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86, 3114-3118 (1989)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 18171)
  AUTHORS   Smith,S., Naggert,J., Williams-Ahlf,B. and Amy,C.M.
  TITLE     Intron-exon organization of the gene for the multifunctional animal
            fatty acid synthase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 1105-1108 (1992)
  STANDARD  full automatic
COMMENT     Accession number M84761 reports the complete genomic sequence for
            rat fatty acid synthase.
FEATURES             Location/Qualifiers
     CDS             join(1274..1400,1938..2090,3114..3287,3476..3676,
                     3852..3974,4062..4177,4267..4401,5012..5474,5593..5780,
                     6018..6207,6712..6806,7014..7148,7226..7429,7535..7650,
                     7833..8005,8077..8268,8343..8423,8516..8695,8853..9032,
                     9106..9309,9571..9857,10250..10636,10719..10883,
                     10962..11080,11163..11317,11424..11630,11834..11984,
                     12066..12244,12332..12451,12567..12689,12773..12996,
                     13345..13546,13662..13813,13925..14016,14184..14335,
                     14416..14661,14861..15049,15228..15455,15544..15764,
                     15883..15981,16162..16413,16496..16633)
                     /product="fatty acid synthase"
                     /gene="fatty acid synthase"
                     /codon_start=1
                     /translation="MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGL
                     YGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRG
                     TNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTA
                     CSSSLLALQNAYQAIRSGECPAATVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDS
                     GNGYCRAEAVVAVLLTKKSLARRVYATILNAGTNTDGCKEQGVTFPSGEAQEQLIRSL
                     YQPGGVAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQSPLLIGSTKSNMGHPEP
                     ASGLAALTKVLLSLENGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGIVGINS
                     FGFGGANVHVILQPNTQQAPAPAPHAALPHLLHASGRTMEAVQGLLEQGRQHSQDLAF
                     VSMLNDIAATPTAAMPFRGYTVLGVEGHVQEVQQVPASQRPLWFICSGMGTQWRGMGL
                     SLMRLDSFRESILRSDEALKPLGVKVSDLLLSTDEHTFDDIVHSFVSLTAIQIALIDL
                     LTSMGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDANLPAGSMAAVG
                     LSWEECKQRCPPGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAF
                     HSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLV
                     SPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGVKPSCTIIPLMKRDHKDNLEFFLT
                     NLGKVHLTGIDINPNALFPPVEFPVPRGTPLISPHIKWDHSQTWDIPVAEDFPNGSSS
                     SSATVYNIDASSESSDHYLVDHCIDGRVLFPGTGYLYLVWKTLARSLSLSLEETPVVF
                     ENVTFHQATILPRTGTVPLEVRLLEASHAFEVSDSGNLIVSGKVYQWEDPDSKLFDHP
                     EVPIPAESESVSRLTQGEVYKELRLRGYDYGPHFQGVYEATLEGEQGKLLWKDNWVTF
                     MDTMLQISILGFSKQSLQLPTRVTAIYIDPATHLQKVYMLEGDTQVADVTTSRCLGVT
                     VSGGVYISRLQTTATSRRQQEQLVPTLEKFVFTPHVEPECLSESAILQKELQLCKGLA
                     KALQTKATQQGLKMTVPGLEDLPQHGLPRLLAAACQLQLNGNLQLELGEVLARERLLL
                     PEDPLISGLLNSQALKACIDTALENLSTLKMKVVEVLAGEGHLYSHISALLNTQPMLQ
                     LEYTATDRHPQALKDVQTKLQQHDVAQGQWDPSGPAPTNLGALDLVVCNCALATLGDP
                     ALALDNMVAALKDGGFLLMHTVLKGHALGETLACLPSEVQPGPSFLSQEEWESLFSRK
                     ALHLVGLKKSFYGTALFLCRRLSPQDKPIFLPVEDTSFQWVDSLKSILATSSSQPVWL
                     TAMNCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSSTSHVPKLDPGSSELQKVLESDL
                     VMNVYRDGAWGAFRHFQLEQDKPEEQTAHAFVNVLTRGDLASIRWVSSPLKHMQPPSS
                     SGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDKCGRRVMGL
                     VPAEGLATSVLLSPDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQHGETVLIH
                     SGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHV
                     LLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVT
                     FHGILLDALFEGANDSWREVAELLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKH
                     IGKVLVQVREEEPEAMLPGAQPTLISAISKTFCPEHKSYIITGGLGGFGLELARWLVL
                     RGAQRLVLTSRSGIRTGYQAKHVREWRRQGIHVLVSTSNVSSLEGARALIAEATKLGP
                     VGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSV
                     SCGRGNAGQSNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIILEAMGTNDTVV
                     GGTLPQRISSCMEVLDLFLNQPHAVLSSFVLVEKKAVAHGDGEAQRDLVKAVAHILGI
                     RDLAGINLDSSLADLGLDSLMGVEVRQILEREHDLVLPIREVRQLTLRKLQEMSSKAG
                     SDTELAAPKSKNDTSLKQAQLNLSILLVNPEGPTLTRLNSVQSSERPLFLVHPIEGSI
                     TVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRVAGYSFGAC
                     VAFEMCSQLQAQQGPAPAHNNLFLFDGSHTYVLAYTQSYRAKLTPGCEAEAEAEAICF
                     FIKQFVDAEHSKVLEALLPLKSLEDRVAAAVDLITRSHQSLDRRDLSFAAVSFYYKLR
                     AADQYKPKAKYHGNVILLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLE
                     GRGLESIINIIHSSLAEPRVSVREG"
                     /citation=[1]
     5'UTR           1..1273
                     /gene="fatty acid synthase"
     exon            1..77
                     /number=1
                     /gene="fatty acid synthase"
     old_sequence    1..15
                     /note="replace 'CGCCCTGGGATCCCT' in old_sequence"
                     /gene="fatty acid synthase"
                     /citation=[1]
     old_sequence    16..30
                     /note="replace 'GCCTGTCAGGAGTGA' in old_sequence"
                     /gene="fatty acid synthase"
                     /citation=[1]
     old_sequence    31..45
                     /note="replace 'CCAGCCCAACCCCTG' in old_sequence"
                     /gene="fatty acid synthase"
                     /citation=[1]
     exon            1265..1400
                     /number=2
                     /gene="fatty acid synthase"
     exon            1938..2090
                     /number=3
                     /gene="fatty acid synthase"
     exon            3114..3287
                     /number=4
                     /gene="fatty acid synthase"
     exon            3476..3676
                     /number=5
                     /gene="fatty acid synthase"
     exon            3852..3974
                     /number=6
                     /gene="fatty acid synthase"
     exon            4062..4177
                     /number=7
                     /gene="fatty acid synthase"
     exon            4267..4401
                     /number=8
                     /gene="fatty acid synthase"
     exon            5012..5474
                     /number=9
                     /gene="fatty acid synthase"
     exon            5593..5780
                     /number=10
                     /gene="fatty acid synthase"
     exon            6018..6207
                     /number=11
                     /gene="fatty acid synthase"
     exon            6712..6806
                     /number=12
                     /gene="fatty acid synthase"
     exon            7014..7148
                     /number=13
                     /gene="fatty acid synthase"
     exon            7226..7429
                     /number=14
                     /gene="fatty acid synthase"
     exon            7535..7650
                     /number=15
                     /gene="fatty acid synthase"
     exon            7833..8005
                     /number=16
                     /gene="fatty acid synthase"
     exon            8077..8268
                     /number=17
                     /gene="fatty acid synthase"
     exon            8343..8423
                     /number=18
                     /gene="fatty acid synthase"
     exon            8516..8695
                     /number=19
                     /gene="fatty acid synthase"
     exon            8853..9032
                     /number=20
                     /gene="fatty acid synthase"
     exon            9106..9309
                     /number=21
                     /gene="fatty acid synthase"
     exon            9571..9857
                     /number=22
                     /gene="fatty acid synthase"
     exon            10250..10636
                     /number=23
                     /gene="fatty acid synthase"
     exon            10719..10883
                     /number=24
                     /gene="fatty acid synthase"
     exon            10962..11080
                     /number=25
                     /gene="fatty acid synthase"
     exon            11163..11317
                     /number=26
                     /gene="fatty acid synthase"
     exon            11424..11630
                     /number=27
                     /gene="fatty acid synthase"
     exon            11834..11984
                     /number=28
                     /gene="fatty acid synthase"
     exon            12066..12244
                     /number=29
                     /gene="fatty acid synthase"
     exon            12332..12451
                     /number=30
                     /gene="fatty acid synthase"
     exon            12567..12689
                     /number=31
                     /gene="fatty acid synthase"
     exon            12773..12996
                     /number=32
                     /gene="fatty acid synthase"
     misc_feature    13154..13254
                     /note="short interspersed repetitive DNA"
                     /gene="fatty acid synthase"
                     /label=SINE
     exon            13345..13546
                     /number=33
                     /gene="fatty acid synthase"
     exon            13662..13813
                     /number=34
                     /gene="fatty acid synthase"
     exon            13925..14016
                     /number=35
                     /gene="fatty acid synthase"
     exon            14184..14335
                     /number=36
                     /gene="fatty acid synthase"
     exon            14416..14661
                     /number=37
                     /gene="fatty acid synthase"
     exon            14861..15049
                     /number=38
                     /gene="fatty acid synthase"
     exon            15228..15455
                     /number=39
                     /gene="fatty acid synthase"
     exon            15544..15764
                     /number=40
                     /gene="fatty acid synthase"
     exon            15883..15981
                     /number=41
                     /gene="fatty acid synthase"
     exon            16162..16413
                     /number=42
                     /gene="fatty acid synthase"
     exon            16496..18171
                     /number=43
                     /gene="fatty acid synthase"
     3'UTR           16634..18171
                     /gene="fatty acid synthase"
     polyA_signal    17367..17372
                     /note="produces 8.3 kb mRNA"
                     /gene="fatty acid synthase"
                     /evidence=EXPERIMENTAL
     polyA_signal    18152..18157
                     /note="produces 9.1 kb mRNA"
                     /gene="fatty acid synthase"
                     /evidence=EXPERIMENTAL
BASE COUNT     3717 a   5129 c   5222 g   4103 t
ORIGIN
        1 agagagacgg cagcagcgtc ccgtccagtt cgcctgccgc gctcctcgct tgtcgtctgc
       61 ctccagatcc cagacaggta cgccgctgcg ttcggggttc cgggatggca ggccggtgtc
      121 ggggtgccgc ggctccagtg ggaggacagg cgggcgccca tcctcaacag ccctgcgctc
      181 acaaaagcgc cgccgcgccc ctccgacagc caaccacccg gctgtgcgcc gcggtccggc
      241 cgagaggggc gcgggagggg tgtgcggaga gccagcgcgg cgggccgctg tcacgtgggc
      301 gccgcgccag ccgggtgcag gaggctgggt gcctcgtgga tggggccggg gcctccactc
      361 tcatccggag gctttggcag ggcacaggag gccgcggtgg tacccgggct ccagtttgga
      421 gaggccagtt gtgggtctgg gagcgcacga ggccccaggg gcctcagcgg aagtcatcag
      481 accatccagg cctcaccggc tgggtggcgc ggaagccttc tccttggact acggctgcaa
      541 ggcctgaact gccctgggca agtgccttag ggaccagagg atctatcaaa cccttcagct
      601 ggctcagcca ggttacaagg tgttcgacca aatggcgaga ggcttctcct gtcccggatc
      661 cgcacctagt taggagtggt actctaggtc ggatctttgc tgaaaggatc cggttggcag
      721 gggatcggtt tgcctcagcc ctgctaggcc tgagcactaa gtagtcgggc ctgttctctc
      781 tgggtcctta ccatgcctgg cgttctggct ggccctgcag ggcagtcagt ctccaccctc
      841 atcatgaaag ggaagcgttg gcttccccgt ggcttgaggt gagagtgtcc cagaccctgc
      901 ttcttgaagc cccacttctg tttgcaagtt ccttatgatt gggatggagc acccagtagg
      961 caactggaga tcatatggtc ccaggtaact agcaaggcat ggtagggtca ggccaggtca
     1021 tgtgtctgga agggattaaa aacctcagaa gtagctatcc cgtgcaaggg aacccgagca
     1081 cccgggctca tccattgatt atagctgggt cctgctagtt tccaccactg gggggctttc
     1141 tgagcccttt gctctcagaa agtcagggcc tggctgtgag gtgtgctacc tgtggattca
     1201 ggtggctgta gctgggaatg actctatgag ggaggcccac caggctacct accttccccc
     1261 acagagaaga gccatggagg aggtggtgat agccggtatg tccgggaaat tgcccgagtc
     1321 agagaacctg caggagttct gggccaacct cattggcggt gtggacatgg tcacagacga
     1381 tgacaggagg tggaaggctg gtgagtgtcc cctcgggatc aggcagcagg acagactgag
     1441 agtctcaccc aagatgcttc tagagacagt gaactccctg tagagctgtg aggttgagaa
     1501 ccggttagaa tgagaaggga caggtgtctt ggttggttcc gcatgcaaga cacccaaggt
     1561 gggccgtaga agaggactgg ccctttggat ctcccatctg taacctctgc cctgagctgg
     1621 cggatagtgt ctaagatgac gctcacaccc agtggattct aacagtgcca tagagcagct
     1681 agctctacct gatgggcagg tgtgagtcac actgggctgg cctggccagc ctcggagtag
     1741 gcagagggtc tcccagtcag gtcggggtta ccagggggtg atcgccagcc tcacttcctg
     1801 ctcctacagg ttttgctttg ggtcacccac atgtggcggt tttggggctc ctcattagca
     1861 gtgaggctgg gtcactctct gggaaccttc ctccaggaca ggttggttcc ctggcctcag
     1921 actgtgatgt tccacagggc tctatgggtt gcctaagcgg tctggaaagc tgaaggatct
     1981 gtccaagttc gacgcctcct tttttggggt ccaccccaag caggcacaca caatggaccc
     2041 gcagctccgg ctgctgctgg aagtcagcta tgaagctatt gtggacggag gtgggtcatt
     2101 ggggtattat tattgccctt tttaggactt actgtcatga gggctgggga cgtagtccag
     2161 tgggagagca cttgcctagt atgcacaagg acctgggaac atcatcatcc ccagtccagg
     2221 aaaaggaaac acaacaatga taccttcttg gctctgagat gtcaagagct cagagacagg
     2281 catggatggc atgggtccct ctagctatgt ccccaaccct gatgtagggc cagtggctca
     2341 ggaggcgggg gccctgagca gggcacgggt ttcacaacca cacacttagt gtcccaggcg
     2401 cgccctgtta ccccagttac ttcactcccc gacgtctggt tgttcttgga ctgagggcgg
     2461 ggcttacagc aggtagcact gcaggggctc agcctcagct ttggcaacaa cccagtccca
     2521 ctggctgtct ctcactctgg atcctgctgc ttgggtcatg gacgtgtccc cagggataga
     2581 aggccccata gtgggcagcc agtgtgggtt agtatggcgg gggtgagctt caggttggta
     2641 gatgctaatt aaccctgtac ttgataaaca gcttgatgta taactgccct ggggtagagt
     2701 agaagaccag aggatgcagg atcctggtaa cctcggtggt gaaaatgaag gtcctcacct
     2761 tgggcctgtc tggctgccca ggctctatca atggctgggc acagctccca gggggttacc
     2821 cactgtcctc tgctttccca gcttggacac ttggtctttg tcttcttgta tctccttatc
     2881 acagcctgtc ccagggcagg ctgcccttgg cactagagaa ctcattggcc agcggcctct
     2941 cgagacccac cagtaacacc agagcccgag ggagttgccc tcagacaatg ctgtcctctg
     3001 tcttaactat agcctcctat ggttgcagct ctgacccaga ccttagaggt ccactgtggc
     3061 ccctatggta cccctctgac ccaaacccat gtggttattg ctgcccccgg caggtatcaa
     3121 cccggcctca ctccgaggaa caaacactgg tgtctgggtg ggtgtgagtg gttccgaggc
     3181 gtcggaggcc ctgagcagag atcctgagac tcttctgggc tacagcatgg tgggctgcca
     3241 gagagcaatg atggccaacc ggctctcttt cttcttcgac ttcaaaggtg ggtgggcagc
     3301 ccagctctgg gcacgaccca gctgtatgtg cattcaccta cacaaccctt ttggactcag
     3361 acttccttat tcctggggaa ggcactgagt ggggtactca cagcccggga ggcggggggt
     3421 gtgggacagc atctgcccaa gggtacccac acccacttta tgaccttgtc cacaggaccc
     3481 agcattgccc tggacacagc ctgctcctct agcctactgg cactacagaa tgcctatcag
     3541 gctatccgca gtggggagtg ccctgctgcc actgtgggcg ggatcaacct gctgctaaag
     3601 cctaacacct ctgtgcagtt catgaagcta ggcatgctca gccccgatgg cacctgcaga
     3661 tcctttgatg attcaggtaa ggttggcctg ggtagggatc gttaggctct actttgcagg
     3721 gctccagcct gtaccctgag tggcatctgg gctcctggtg gtgtggggaa gggaggacgt
     3781 gtgcatgtat agactcatag cacacacccc atcacaccag agcacctagc tgaggtgttg
     3841 atctactcta gggaacgggt attgccgtgc tgaggctgtc gtggcagttc tgctgactaa
     3901 gaagtccttg gctcggcgag tctatgccac tattctgaat gccgggacga acacagatgg
     3961 ctgcaaggag caaggtgggc atggagggaa agagcatggg gaatggggac gtggagcaca
     4021 caaggcttga caccgtactg taccattacc catctccgta ggcgtgacat tcccctctgg
     4081 agaagcccag gaacaactca tccgttctct gtatcagccg ggcggtgtgg cccccgagtc
     4141 tcttgaatat attgaagccc atggcacggg caccaaggtg aaagcccttt ccagcccata
     4201 cctgccactc ctctatcctc actagaggga cctggctgca gccttaacct actctgtccc
     4261 ctgcaggtgg gggaccccca ggaactgaac ggcattactc ggtccctgtg tgctttccgc
     4321 cagagccctt tgttaattgg ctccaccaaa tccaacatgg gacaccctga gcctgcctcg
     4381 gggcttgcag ccctgaccaa ggtgagcagg ctgggggctc tgagtcaaga atgatgtgga
     4441 taggtctgta ctgtgaccac cacttgacct accccggggc tcctgcctgc tcaccaacca
     4501 gccctttggc tgtaccgttg ctgaagtggc agggagactg ggtacactcc ctgtggttgc
     4561 tgtgctgact tacatagctt ctggctgaag gaaacacttg gctgcataaa ggacaggtgc
     4621 agttctgagg aagtatctag gcagccaggt ctagcagaat gccccattct gagatgagga
     4681 gagaggagcg agccagtgtc tgatctggtg tgttctttcc ctgggtgacc ctgcacgtgt
     4741 aggcaccttc agcttgtttc tatgctggga ggtgtgcggt tgtctggatg acctatctgt
     4801 tggggcttct gggcctggct ctcacgtagt ttgtgcgctc aagccactgc ccccttgact
     4861 tgggcaccat gcaccctgac cactggtggc aaggccagag aaagacaagg gtcttggtgc
     4921 ccagtaccat acacagctca tgggccctgg ggaggtaggt ggccacgctt ggtggggaca
     4981 gctgcccagt aaccatgtgt tttgtctaca ggtgctgtta tccctagaaa atggggtttg
     5041 ggcccccaac ctgcatttcc acaaccccaa ccctgaaatc ccagcacttc ttgatgggcg
     5101 gctgcaggtg gtcgataggc ccctgcctgt tcgtggtggc atcgtgggca tcaactcgtt
     5161 tggcttcgga ggtgccaatg ttcacgtcat cctccagccc aacacacagc aggccccagc
     5221 acctgcccca catgctgccc taccgcattt gctgcatgcc agtggacgga ccatggaggc
     5281 agtgcagggc ctgctggaac agggccgcca gcacagtcag gacttggcct ttgtgagcat
     5341 gctcaatgac attgcagcaa cccctacagc agccatgccc ttcagaggtt acactgtgtt
     5401 aggtgttgag ggccatgtcc aggaagtgca gcaagtgcct gccagccagc gcccactctg
     5461 gttcatctgc tcaggtgagc ctgctcccat gttcccaggc tggccccaaa ggaggagggg
     5521 agtcggtccc ttttcttgag ggtgaggctg gaggttggcc atgctatggc cctgataagc
     5581 tttctggtac agggatgggc acacagtggc gtggaatggg gctgagcctt atgcgcctgg
     5641 acagtttccg tgagtccatc ctgcgctctg atgaggctct gaagcccttg ggagtcaaag
     5701 tgtcagacct gctgctgagc actgatgagc acacctttga tgacatcgtg cattcctttg
     5761 tgagcctcac cgccatccag gtatgccacc ttcgtggtac tcggaccccg ggacactcca
     5821 caccagagtc acgtcagtac ataggctcga tcggtatgta ggcagagctt aaataggtac
     5881 acctgaggag gagcagggtc ttctcagagg accctaagag aggcttggcg tgcttggtgt
     5941 gctcagcttt actgtgaggg atggtcaggc tagtgatcta gggtctacgt gacatggctt
     6001 atatccccac ttcgcagatt gccctcatcg acctgctgac gtctatgggg ctgaaacctg
     6061 atggcatcat tgggcactcc ttgggagagg ttgcctgtgg ctatgcagat ggctgtctct
     6121 cccagagaga ggctgtgctt gcagcctact ggagaggcca gtgcattaag gatgccaacc
     6181 ttccggctgg atccatggca gctgttggta ggatctctct cagggccccc gacctcatta
     6241 ggcaccaggt tcttcttgga aggggtttct gtcctgggta ctcaaaagaa tcagttagct
     6301 ttgttgtgag acatggggtt gcaaagggag aagtcactct gctcagatta tctttatagg
     6361 agacttcatt tctgacccca caggcccgag caaggtatga aacaccatac acatcagatg
     6421 agggttccag gagctgagga gagccactta ccaaccctag gtgttcatcg cccagcttct
     6481 cagctgctta ccccctacac cacttaggtg tcatttctga ggtccggctc ctttcctaca
     6541 ctccctccat aatgacacct ctcttgagat cagaaacagc agggagggag taaaggtgcc
     6601 ctggaaggtc gactcttagc atcccaacac cattggctct aagtagtgct catggtccag
     6661 gaggatgggc tgagttcggg ccagctctga ggccagcctc tctgcttata ggtttgtcct
     6721 gggaagaatg taaacaacgc tgccctcctg gtgtggtgcc tgcctgccac aactctgagg
     6781 acactgtgac catctctgga cctcaggtag gcctgcaatc atagcaggac ttctgttccc
     6841 tgcaattttg ccctggccct gcctaggagg caaggcctcc tcagtctgtg tccaccaagt
     6901 tctgaagggc ccagctggtg agctacactt gtcgcaggcc ctctgggtgg actgtgtccc
     6961 tgaccaggga aagccagtcc aggccccctg accactggcc ttgatgcctg caggctgcag
     7021 tgaatgaatt tgtggagcag ctaaagcaag agggcgtgtt tgccaaggag gtgcgaacag
     7081 gtggcctggc cttccactcc tacttcatgg aaggaattgc ccccacgctg ctgcaggctc
     7141 tcaagaaggt gagtacctgg ccatgtgctt ggaccccagg gcacggtgac ttgacctcac
     7201 tcgctaacca agcgtctgtg tgcaggtgat ccgggagcca cggccacgct cagcacgctg
     7261 gctcagcacc tctatccctg aggcccagtg gcagagcagc ctggcccgca catcttctgc
     7321 tgagtacaac gtcaacaacc tggtgagccc tgtgctcttc caggaagcac tgtggcacgt
     7381 ccccgagcac gccgtggtgc tggagattgc accccatgca ctgttgcagg tgagcactgg
     7441 tccgcctggg atggggcaca tcagcctgcc agtcactggc gaaggcgagt ggcacggaag
     7501 gggtcggagc ctagctctcc tttgctatgt gtaggctgtc ctgaagcgag gcgtgaagcc
     7561 tagctgcacc atcatcccct tgatgaagag ggaccataaa gataacttgg agttcttcct
     7621 caccaacctc ggcaaggtgc acctcacagg gtaggtctcc cttctgtctg ctgctcgtgt
     7681 gcaggcccac accaaccccc atgagagggg ttgctgtggc ctagctcagt gctggccctc
     7741 ggtcctcatc ttggccatct tggggtctta gagcaaaact agggccacag actctcaggg
     7801 acaggtgtgt cacttaactt gtttgtcacc agcatcgaca tcaaccctaa tgccttgttc
     7861 ccacctgtgg aattcccggt tccccgaggg actcctctca tctcccctca catcaagtgg
     7921 gaccacagtc agacttggga tatcccagtt gctgaagact tccccaacgg ttccagctcc
     7981 tcctcagcta cagtctacaa cattggtgag ccaggctccg tggtcagtgg gttcctccca
     8041 ggcctgtggg cccgtgctga ggcattgtcc ttacagacgc cagttccgag tcatctgacc
     8101 actacctggt cgaccactgc attgacggcc gtgtcctctt ccctggcact ggctacctgt
     8161 acctggtgtg gaagacactg gctcgaagcc tgagcttgtc cctagaagag acccctgtgg
     8221 tgtttgagaa cgtgacattt catcaggcca ccatcctgcc caggacaggt aagaggccct
     8281 tcagtggggg ctggtgaggt ggttgtgact actccgctct gaccttcttt ttttctctgc
     8341 aggaaccgtg cctctggagg tgcggctgct agaggcctca catgcatttg aggtgtctga
     8401 cagtggcaac ctgatagtga gcggtgagta gtacctggct gggcctgtgt ggctgaggac
     8461 ctcagctcct agcctgcccc atgctcagac cctcctgttg ccctgcctcc tacagggaaa
     8521 gtgtaccagt gggaagaccc tgactccaag ttattcgacc acccagaagt cccgatcccc
     8581 gccgagtccg agtctgtctc ccgcttgacg cagggagaag tatacaagga gctgcggcta
     8641 cgtggctatg actatggccc tcatttccag ggcgtctatg aggccaccct cgaaggtggg
     8701 cagggagcaa tccccgagtc agtgagcatg atgaccagga gccattgtca ctcctgggcc
     8761 atgtcttgct gggggtcagg gaagacggag gaagggagta gaggccctgg agcaggtgag
     8821 gcctcgtgtg ctgagcagcc cccctactgc aggtgagcaa ggcaagctgc tctggaaaga
     8881 caactgggtg accttcatgg acacaatgct gcagatatcc atcctgggct tcagcaagca
     8941 gagtctgcag ctacccaccc gtgtgactgc catctatatt gaccctgcaa cccacctgca
     9001 gaaggtgtac atgctggagg gagacactca aggtagctct ggccctcgct ctgtccactt
     9061 gtcctggact gagcattgcc tacactgacc agtgtgtctc catagtggct gacgtgacca
     9121 cgagccgctg tctgggcgtg accgtctctg gtggtgtcta catttcgaga ctacagacaa
     9181 cagcaacctc acggcggcag caggaacagc tggtccccac cctggagaag tttgtcttca
     9241 caccccatgt ggagcctgag tgcctgtctg agagtgctat cctgcagaaa gagctgcagc
     9301 tgtgcaaggg tgaggatcca aaccttccct cttcttcctc agtctttgcc tttgaaactc
     9361 ctgaggcaag gcctggatgg cggggagctc agggttggtg agagcacagc ctaccttcca
     9421 tgggtagcac ggcactgctg catccttcct attgagtttc cgctcttccc attgctgtgg
     9481 gcttgtcctg tggacacgct aggaagcagg ccctggcagt aggctggagg ccgtagagag
     9541 agaacgtagg cctttctttg tccctcccag gtctggcaaa ggctctgcag accaaggcca
     9601 cccagcaagg gctgaagatg acagtgcctg ggctagagga ccttccccag catggactgc
     9661 ctcgactctt ggctgctgcc tgccagctgc agctcaacgg gaacctgcaa ctggagttag
     9721 gtgaggtact ggctcgagag aggctcctgc tgccagaaga ccctctgatc agtggcctcc
     9781 ttaactccca ggccctcaag gcctgcatag acacagccct ggagaacttg tctactctca
     9841 agatgaaggt ggtggaggtg agtgctggga aggtagacag gccatgtgcg tggatccagg
     9901 gcaatctcag acccgagccc aaggcaggca gccatgatgt agcagctttc tatggccttt
     9961 gtgctttggt ttgttccacc ctaaaagatt gtggggaact tttcactgct accagtccag
    10021 gggatgagat atcagaagga aggcttctgg gaaagaatcc tgggatgctc tgagctctag
    10081 cctgggatgt cgcagacagt ctccacagga gagtagagga gaacactgga agagcctccc
    10141 ggccagcatt gccacaaaac tgagcatgag cagcacggag aggctcaccc aggccccagg
    10201 gttttctgcc tcctagaaac aacagatcta agatgctctc ccacaccagg tgctggctgg
    10261 agaaggccac ttgtattccc acatctcagc actgctcaac acccagccta tgctgcaact
    10321 ggagtataca gccaccgacc ggcaccccca ggccctgaag gatgttcaga ccaagctgca
    10381 gcagcatgat gtagcacagg gccagtggga cccttctggt cctgctccta ccaacctggg
    10441 tgctcttgac cttgtggtgt gcaactgtgc gttagccacc ctgggggatc cagccctggc
    10501 cctggacaac atggtagctg ccctcaagga tggtggtttc ctgctaatgc acacagtgct
    10561 caaaggacat gcccttgggg aaaccctggc ctgcctccct tctgaggtgc agcctgggcc
    10621 cagcttctta agccaggtac tgctcctggg catgcagggc aggtaagggc tgggtatggt
    10681 tccgccagtt cagtacttac aagacttcat acacatagga agagtgggag agcctgttct
    10741 caaggaaggc actgcacctg gtgggcctta aaaagtcatt ctacggtact gcgctgttcc
    10801 tgtgccgccg tctcagccca caggacaagc ccatcttcct gcctgtggag gatactagtt
    10861 tccagtgggt ggactctctg aaggtcaggc tctggggctg ggtaccttgg cttcccctga
    10921 cgtatgatca ccctagaggc tgaccctact ttatcctgca gagcattctg gccacatcct
    10981 cctcccagcc tgtgtggcta acagccatga actgccccac ctcaggtgtg gtaggcttgg
    11041 tgaactgtct ccgaaaagag ccgggtggac accggattcg gtaggaaagg ccctgagagg
    11101 tgcctaccct tccttcctca ccccctccat tcttggtatc cttacccact ttgcccccac
    11161 aggtgtatcc tgctgtccaa cctcagcagc acatctcacg tccccaagct ggaccctggc
    11221 tcttcagagc tacagaaggt gctagagagt gatctggtga tgaacgtgta cagggacggt
    11281 gcctggggtg ccttccgtca cttccagtta gagcagggta agcctgtcca tgccctatat
    11341 acttaatagg cttgtgaggt ggcaggggaa caaggagctg gccaggtagg cccctgtggc
    11401 atccttgctt tctttcccct cagacaagcc cgaggagcag acagcacatg cctttgtaaa
    11461 cgtccttacc cgaggggacc ttgcctccat ccgctgggtc tcttctcccc tgaaacacat
    11521 gcagccgccc tcgagctcag gagcacagct ctgcactgtc tactatgcct cactgaactt
    11581 ccgagatatc atgctggcca cgggcaagct gtcccctgat gccattccag gtgccaacca
    11641 ggatgggggc ttatgattgg gttgctggga gtagagaagg tgcctgtact gtagcagccc
    11701 agtgaggagg agtcctgccc ggctcctggg gaagagaggg ttcccagcac cagaggctgc
    11761 acttgcatcc tgctcccctg acaacctgtc ctagggtctg ggctaacagg agcctccctc
    11821 tgtctacaca caggtaaatg ggccagccgg gactgcatgc ttggcatgga gttctcaggc
    11881 cgtgataagt gcggccggcg tgtgatgggg ctggtacccg cagaaggcct ggccacctca
    11941 gtcctgttat cacccgactt cctctgggat gtaccctcta gctggtgagt ggctggctgc
    12001 agttgggggt tatgtgatct tagttggtgg ccaggctgaa ttgatcctgt gctccgttcc
    12061 ctcaggaccc tggaggaggc ggcttctgtg cctgttgtct acaccaccgc ctactactcc
    12121 ttagtagtgc gtggtcgtat tcagcacggg gaaactgtgc tcattcactc gggctccggt
    12181 ggtgtgggcc aagcggccat ttccattgcc cttagcctgg gctgccgagt cttcaccact
    12241 gtgggtaagg ccctcacccc ctcccgatcc caatcaagga gcttcttgaa ccctgtgggc
    12301 caaacttact ggggtctccc ttgactgaca ggctccgctg agaagcgagc ttacctccag
    12361 gccagattcc ctcagctgga tgacaccagc tttgctaact ctcgagacac atcgtttgag
    12421 cagcatgtgt tactgcacac aggtggcaaa ggtaaatacc ccctgggcca ttgcctgaga
    12481 gtgagtgggt cacatagtca gtccagcgct gaggactgag gtacaggtga gcccagtatg
    12541 accgactgac atgtttgcca ccgtaggggt ggacctggtc ctcaactccc tggcagaaga
    12601 gaagctgcag gccagtgtgc ggtgcttggc tcagcatggc cgcttcctag agatcggcaa
    12661 atttgatctt tctaacaacc accctctggg tatgactcgt agtcaggagc aggggtgggg
    12721 gctggtgttg gggccagggg catcccacag tgaacaggat tctcgaatac aggcatggcc
    12781 atcttcttga agaacgtcac tttccatggg atcctgctgg atgcactttt tgagggggcc
    12841 aacgacagct ggcgggaggt ggcagagctg ctgaaggccg gcatccgtga tggggttgtg
    12901 aagcctctca agtgtacagt gtttcccaag gcccaggtgg aggacgcctt ccgatacatg
    12961 gctcaaggaa aacatattgg caaagtcctt gtccaggtga agtgaggccc tcgggcacca
    13021 agcctggttt cgccttttgt agtgcatttt ttttctaatt atatttactt acttttgatg
    13081 gttgtgagtg gcatgtgtgg gtaccagagg acaacttgca ggagttggtt ctcctccatg
    13141 ggtcatcagg tttttttttg tttttttggt tctttttttt cggagctggg gaccgaaccc
    13201 agggccttgc gcttcttagg taagcgctct accactgagc taaatcccca gcccgggtca
    13261 tcaggtttga tagaagcact gttaactacc cagctgtctc gctggtcctg ggacagcttc
    13321 tgaaccactg ctacttgtat gcaggtacgg gaggaggagc ccgaggctat gctgccaggg
    13381 gctcagccca ccctgatttc cgccatctcc aagaccttct gcccagagca taagagttac
    13441 atcatcactg gtggcctagg tggctttggc ctggaactgg cccggtggct tgtgcttcgt
    13501 ggggcccaaa ggcttgtact aacttcccga tctggaatcc gcacaggtag ggcaagtaga
    13561 agcagttggt agtgtaggct tcccttcagt ggaaagtgtc ctgggagggc tgtaggccac
    13621 tgctttcctc tggtgcagcc ccatttccct gtgtcccata ggctaccaag ccaagcacgt
    13681 tcgggagtgg aggcgccagg gcatccatgt gctagtgtcg acaagcaatg tcagttcact
    13741 ggagggggcc cgtgctctca tcgctgaagc cacaaagctt gggcccgttg gaggtgtctt
    13801 caacctggcc atggtgagaa aagcatgcag ggctctgcgt acctccagag cctgagaccc
    13861 aggctgctgc taagtggggt tagaacctca gagctgcagc atacactaaa accccttctt
    13921 ctaggtttta agggatgcca tgctggagaa ccagactcca gaactcttcc aggatgtcaa
    13981 caagcccaag tacaatggca ccctgaacct tgacaggtag gcagttggtc cctctgctga
    14041 gtttcatgta tgcttgcaat gtatactggt ccctgctgga cttgagggtc tggggaagtg
    14101 aaactgtgcc acccgtggcc ttctgggcct gccctgggga ggtacggaca tgaaagttat
    14161 cagactgaca tgagtaccca cagggcgacc cgggaagcct gtcctgagct ggactacttt
    14221 gtggccttct cctctgtaag ctgcgggcgt ggtaatgctg gccaatccaa ctatggcttc
    14281 gccaactcta ccatggagcg tatttgcgaa cagcgccggc acgatggcct cccaggtggg
    14341 cctctttgtc tagcccaccc ctgcttgtgg tctcactccc caaagcacct caccggctgc
    14401 ctcccttgct ctcaggtctt gccgtgcaat ggggtgccat tggtgacgtg ggcattatct
    14461 tggaagcgat gggtaccaat gacacagtcg ttggcggcac actgccacag cgcatctcct
    14521 cctgcatgga ggtgctggac ctcttcctga atcagcccca cgcagtcctg agcagttttg
    14581 tgctggttga gaagaaagct gtggcccatg gtgatggtga agcccagagg gatctggtga
    14641 aagcagtggc acacatccta ggtaagccag cttccgggac cttcccggct taggtgactt
    14701 ggagccttag ttttcccatc tgtagaagca gacgacagag ttctgtggtc tgaatgctgg
    14761 ccaggccagg tgattggcag tgatgctgga gagccacagt atgtacctgg ttcccacgtc
    14821 cccttctcag taatgaccag ttacccatcc cctttgttag gcatccgcga cctcgcaggg
    14881 attaacctgg acagctcgct ggcagacctc ggcctggact cgctcatggg tgtggaagtg
    14941 cgccagatcc tggaacgtga acatgatctg gtgctaccca ttcgtgaagt acggcaactc
    15001 acactgcgga agcttcagga aatgtcctcc aaggctggct cagacactgg tgcgtaccag
    15061 gcagcaggct gtgagagaca caagtgcatc ctagtattgt aggcagcagc gctgcccttt
    15121 tgcaaagaac acatgggcct gtgcttaatc tgtgtgtgta tgacctcaca agggatgtgt
    15181 accagagccc atgtgccaag gctaccctac accctctgtc tttacagagt tggcagcccc
    15241 caagtccaag aatgatacat ccctgaagca ggcccagctg aatctgagta tcctgctggt
    15301 gaaccctgag ggccctacct taacacgact caactcagtg cagagctctg agcggcctct
    15361 gttcctggtg caccccattg aaggttccat cactgtgttc cacagcctgg ctgccaagct
    15421 cagtgtgccc acctacggtc tgcagtgcac ccaaggtact gtgcacatgg cgaagcagta
    15481 catgctgcct tgggcctccg ttcctcactg actgctggct gagtcctctg tttgtcctta
    15541 cagcggcccc cctggacagc attccaaacc tggctgccta ctacattgat tgcatcaagc
    15601 aggtgcagcc tgaggggccc taccgagtgg ctgggtattc ttttggagct tgtgtagcct
    15661 tcgagatgtg ctcccagctg caggcccagc agggcccagc ccccgcccac aacaacctct
    15721 tcttgtttga tggctcacac acctacgtat tggcgtacac ccaggtgaga gccgggccaa
    15781 ctggtcctaa gcattgccgc ctatgtcttg gctctgaaca cgcttctggg agggtcctgg
    15841 ttactttagc ccttgcagca tcaatctctc cttccctgac agagctaccg ggcaaagctg
    15901 accccaggct gtgaggctga ggctgaagct gaagccatat gcttcttcat taagcagttt
    15961 gttgatgcag agcatagcaa ggtgggcctg acacacccta gagaggacga aaggcaaggt
    16021 cgggagggtt ggggtctctg tgcctttaaa aatggagcag ggaaatccaa gcgcttcttc
    16081 agaaacccgt ctgcccagag aaggcagggc agaccgtgta gccccccatc ccaccccaca
    16141 tgctcagagt cgttgtctta ggtgctagag gccctgctac cactgaagag cctggaggac
    16201 cgggttgctg ctgctgtgga cctcatcact agaagccacc agagcctgga ccgccgtgac
    16261 ctgagctttg ctgccgtgtc cttctactac aagcttcgag ccgccgacca gtataaaccc
    16321 aaggccaagt accacggcaa tgtgatcctg ctgcgggcca agacaggtgg cacctacggc
    16381 gaggacttgg gtgccgatta caacctgtcc caggtaagcg agtgagtggg gcagacgagg
    16441 cggtgtggga cggacgcctg ctggtggtca cagaatgaca cctgaatgtt tacaggtgtg
    16501 tgatgggaag gtgtctgtgc acatcattga gggtgaccac cgtacgctgc tggagggcag
    16561 gggcctggag tctatcatca acatcatcca cagctccctg gctgagcctc gagtgagtgt
    16621 acgggagggc tagacctgcc taccatgaag ccacgaccca caccggccac cagagatgct
    16681 ccgatcccca ccacaccctg agtgcaggga ctggggaggg tcctgctggt gggaccccct
    16741 caccccagtg gcccagcacc accccctccc ctggtggctg ctacaaacag gaccatcaca
    16801 tgtgtcccag ccacttagtg gggttcccag agccactgac ttggaggcac cctggtctgt
    16861 gaagagtcag tggaggccag caagagccaa actgagcctt ttctgccaag tgacatttgt
    16921 cacactggtt gtttctccat taaattctca tatttattgc attgctggga aagaccgccc
    16981 accccagggt taactcattc cagaacccct aaagtgggaa aagccatgtg gggaaggctg
    17041 ctggctggag cccctttttg tcttagccct gtacccgctc actgcagggc agggtatgga
    17101 gagggctggt tcccggggaa cgaggacccc agcagacact gtagcccatg gcccttggtc
    17161 cccagcactc ccggctgcac ccatgatgca gggcctacca gactctgcgg accgcaccgg
    17221 gcactcactg tatttgtttt ccaagattca aattgctgct tgggttttga atttactgca
    17281 gctgtcagtg taaagaaaca tgtctgaact gtgtcctttt tacaccaacc tggtaaaaat
    17341 gctcttgatg ctgtcccgtt gccacaatta aactgcacgt gagctctggc ttccgttcag
    17401 tctctttcca gtcccagacc tgagtcccca gagcctccac agctcttaca gtgagaatca
    17461 aattggccca ctccttggaa ggcgtggcat tctgtcagag taaaaggaaa gtagagtgtg
    17521 ctgattcacg ttcagcgtgt ggggctggct agagaccttg gcactgtagt gaacagaatg
    17581 tgtccacctt taagtcaccc tgaaggcatc accatagcta cagcctcacc caggggtaga
    17641 gaatagtact gtctacttgt tgactacctg gcagttggtg ccagccccta tagaggaaaa
    17701 cagcagtgtg tggccactgt gagaagcata tccctggaaa caggtgacca gagcagaggg
    17761 ctaatgccta cctgagtcac acaaaactga ccaggcttga gtgtccagaa gagtctatca
    17821 gaaggccaca gcattcagtc ctatccacag agagcagcag actaagttgt ctccttgcca
    17881 gcttagaaaa ctgcagtgct ggggtacagg tagggtgttc aggaggtccg ggccccagtg
    17941 attagtctaa gactgaagca tctggttggc tgtggtccca cctagaaaat tcttaaagct
    18001 cttgtcatgt acttcctggg aaggacctac cctgtctcaa taatgtctct agctcgttgg
    18061 agtctactga ctcaaacatt tataaagtgt cctagaaagg cctgactccc ctacaaggct
    18121 gtgtgatcct tcaaactcac atatgtgagc caataaaacc ttgagactct a
//