From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human endothelin (ETN) gene, complete cds.
Date: 22 Aug 92 10:00:59 GMT
Distribution: bionet
Checksum: 42544     4

LOCUS       HUMETN4      1330 bp ds-DNA             PRI       22-AUG-1992
DEFINITION  Human endothelin (ETN) gene, complete cds.
ACCESSION   M25380 J04819
KEYWORDS    endothelin.
SEGMENT     4 of 4
SOURCE      Human leukocyte DNA and human umbilical vein endothelial cell cDNA
            to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Bloch,K.D., Friedrich,S.P., Lee,M.-E., Eddy,R.L., Shows,T.B.Jr. and
            Quertermous,T.
  TITLE     Structural organization and chromosomal assignment of the gene
            encoding endothelin
  JOURNAL   J. Biol. Chem. 264, 10851-10857 (1989)
  STANDARD  simple staff_review
COMMENT     Draft entry and computer readable copy of sequence [1] kindly
            submitted by K.D.Bloch (06-AUG-89).
FEATURES             Location/Qualifiers
     prim_transcript <1..1330
                     /note="ENT mRNA and introns"
     intron          <1..100
                     /note="ENT intron D"
     CDS             join(M25377:519..582,M25378:101..269,M25379:101..256,
                     M25379:421..564,101..206)
                     /note="endothelin prepropeptide"
                     /codon_start=1
                     /translation="MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPP
                     WRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKA
                     TDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQL
                     VRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW"
     exon            101..>206
                     /number=5
                     /note="endothelin prepropeptide"
                     /gene="EDN1"
BASE COUNT      392 a    271 c    257 g    410 t
ORIGIN      About 1.3 kb after segment 3.
        1 tcaggttttg tttgtgccag attctaattt tacatgtttc ttttgccaaa gggtgatttt
       61 tttaaaataa catttgtttt ctcttatctt gctttattag gtcggagacc atgagaaaca
      121 gcgtcaaatc atcttttcat gatcccaagc tgaaaggcaa gccctccaga gagcgttatg
      181 tgacccacaa ccgagcacat tggtgacaga cttcggggcc tgtctgaagc catagcctcc
      241 acggagagcc ctgtggccga ctctgcactc tccaccctgg ctgggatcag agcaggagca
      301 tcctctgctg gttcctgact ggcaaaggac cagcgtcctc gttcaaaaca ttccaagaaa
      361 ggttaaggag ttcccccaac catcttcact ggcttccatc agtggtaact gctttggtct
      421 cttctttcat ctggggatga caatggacct ctcagcagaa acacacagtc acattcgaat
      481 tcgggtggca tcctccggag agagagagag gaaggagatt ccacacaggg gtggagtttc
      541 tgacgaaggt cctaagggag tgtttgtgtc tgactcaggc gcctggcaca tttcagggag
      601 aaactccaaa gtccacacaa agattttcta aggaatgcac aaattgaaaa cacactcaaa
      661 agacaaacat gcaagtaaag aaaaaaaaaa gaaagacttt tgtttaaatt tgtaaaatgc
      721 aaaactgaat gaaactgtta ctaccataaa tcaggatatg tttcatgaat atgagtctac
      781 ctcacctata ttgcactctg gcagaagtat ttcccacatt taattattgc ctccccaaac
      841 tcttcccacc cctgctgccc cttcctccat ccccatacta aatcctagcc tcgtagaagt
      901 ctggtctaat gtgtcagcag tagatataat attttcatgg taatctacta gctctgatcc
      961 ataagaaaaa aaagatcatt aaatcaggag attccctgtc cttgattttt ggagacacaa
     1021 tggtataggg ttgtttatga aatatattga aaagtaagtg tttgttacgc tttaaagcag
     1081 taaaattatt ttcctttata taaccggcta atgaaagagg ttggattgaa ttttgatgta
     1141 cttatttttt tatagatatt tatattcaaa caatttattc cttatattta ccatgttaaa
     1201 tatctgtttg ggcaggccat attggtctat gtatttttaa aatatgtatt tctaaatgaa
     1261 attgagaaca tgctttgttt tgcctgtcaa ggtagtgact ttagaaaata aatatttttt
     1321 tccttactgt
//