From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: New Hepatitis non-A, non-B associated virus
Date: 24 Jul 92 10:06:24 GMT
Distribution: bionet
Checksum: 33328    10

LOCUS       HPCABV       5001 bp ss-RNA             VRL       24-JUL-1992
DEFINITION  New Hepatitis non-A, non-B associated virus
ACCESSION   X53411
KEYWORDS    Hepatitis non-A, non-B associated virus.
SOURCE      Hepatitis C virus RNA.
  ORGANISM  Hepatitis C virus
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Togaviridae incertae sedis.
REFERENCE   1  (bases 1 to 5001)
  AUTHORS   Seelig,R., Seelig,H.P. and Burckhardt,J.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     *source: isolate=patient N, 1981;
            From EMBL    entry HNABV;  dated 27-APR-1992.
FEATURES             Location/Qualifiers
     CDS             join(3986..5001,1..160)
                     /note="circular sequence"
                     /codon_start=1
                     /translation="MKKHRCFYKRFAALLASLMVSFSLCTPCFAGFDSEADMPSLDDF
                     YTHHGSWFVWRSATISGFPFYELLCSPITVSGTTYSLPYSVSYSTNAFDVSYLANDSG
                     KSYDYACAFPLPLRGASGYWYELPSFPIGSGMKFDTCSVRVYSTAAQPSGTYGFLTSS
                     FSRSDRILSFGNTASSSSGSSTDTLDSFSFSSPFYSYPFAIRSTSSSSASGYVLQGGD
                     NNFIIPSPGYSSTRALNLGVTRYLRGTNAFVPYPSGYTIPSSDIGFVFVQQPSSSPVY
                     SASAFDTTGSFAFSLLVPASRLPDVKLGDWLSDSPEDLQDAITNEFGVDSGTLKDSKD
                     NLNSWNSASSVDSDVASGASGLLGGLFQNLGTFLFSVSLLCFGAVVLRMLIRKAVDG"
     misc_feature    419..435
                     /note="CTG box 1"
     CDS             539..1060
                     /gene="ORF2"
                     /codon_start=1
                     /translation="MTVQQYDYLKASAQAVADMDSKAAADSPSEAAPAPEEPAQNIIE
                     SPDLREGYVPQEEELPFEGSLTAYDDRAADTPALYANLPNVSNSFTTIMDWFGDTFFI
                     ERTETVHKSGYTSERYSYNSSTQLIQLPYAEDSTTTSQVLNPQACVSALLVVLVFVTT
                     VTWIKNAIWGRMS"
     CDS             1476..2099
                     /gene="ORF3"
                     /codon_start=1
                     /translation="MLYGILIFCVCWLFVYIDNYCKNPYKLEAVVGSKGSGKSLYMSR
                     VADKWLRSSKGFIYSNMGIGYDLEPEYWKQTFAPDSLILIDEIGVLHSNRDFKAMPRE
                     AVEFFKMQRKYHLTIVVSSQTMDFDKKIRDLCDRIYLCNRIGWFCRLTPYRSCIAMEH
                     RPEGGQELVNTVRKAGRAKWYTIPKSVKQVSALEYDTEQVISKTPSK"
     CDS             2403..3539
                     /gene="ORF4"
                     /codon_start=1
                     /translation="MKTVVKLDYATFAFEQGSISIPKIEDALAQCDLHFAQISNASEN
                     SPYNSPAGLFFKPNNGAKQSPHSLQVSGHGCELFRSTLPRLASLMQEGHEFGHFSRLD
                     FCFDVVMTKLRWREFYLGVISASVDEMNNPEKARKVRKFMYQGYGDSTTVYIGRRKSS
                     AVFCRIYNKSLQDPEKKLCAASGELLDCPDDSYIIRYEMELKFTSRVNSFGRTVYDPS
                     PLFWQYYEDPDKLFAYLRKVWNRYGNDTLLPDGWEDMQFVTDIEARNIQFTKGLFRPL
                     SNDLAQKFSVSIHTEEQKMSYVANTFGHRIIDILLYRPELLFLACCKWEQFYNECLPF
                     SPLALTQVVAQFSESSRIAVEEFREVADDPSPFSEDGFDDISLF"
     repeat_region   3046..3059
                     /rpt_type=direct
     misc_feature    3306..3324
                     /note="CTG box 2"
     repeat_region   3487..3500
                     /rpt_type=direct
BASE COUNT      996 a   1130 c   1088 g   1787 t
ORIGIN
        1 gaattctgcc tcttctgttg attctgatgt tgcctccggt gcttctggtc ttcttggcgg
       61 tcttttccag aatttaggca cgtttctttt ctctgtttct ctcctttgct ttggcgctgt
      121 tgttcttcga atgcttatta gaaaggcggt tgacggatga cttttcttga tttcttcaaa
      181 tcagttttta accttttcgg ttctggtggc gctctcgtca ttgccgttgt tgtttttctt
      241 gtcggcctcg gtatttataa gttcgtaaag gattggttgc catggtagac tttgtttccg
      301 ctcttggcgt ttttacctcg tttatcgcca atgtgctttc tatttccttt tttggctttg
      361 gtacttttgg caactttatt ttggtttgtc ttttgctttc gcttgttggc tttgttctct
      421 gtggcctttg ggatggaggt gataaatagt ggaaatccct attattatca atacttgggt
      481 tgatgctgac ggcgttaccg tctatacagt gcagtataaa gatggtagca cttgcgatat
      541 gaccgtccag cagtatgatt atctcaaggc atccgcgcag gctgtcgccg atatggactc
      601 taaagccgct gctgattctc cttcggaagc tgctcctgct cccgaggaac ctgcacagaa
      661 tattattgaa tctcctgacc tccgcgaagg ttatgtgccg caggaagaag aattaccttt
      721 tgaggggagt ttaaccgctt atgatgaccg cgcagcagat actccggctt tgtatgctaa
      781 tctccctaac gtctctaata gtttcactac tattatggat tggttcggag atacgttttt
      841 tatcgaacgt actgagacgg tgcacaagtc cggctatacg tctgaaaggt attcctataa
      901 cagctcgact caacttattc agcttcctta tgcggaggat tccactacta cgtctcaggt
      961 tctcaatccg caagcttgcg tttctgcttt gcttgttgtc cttgtcttcg ttactactgt
     1021 tacttggatt aaaaacgcga tttgggggcg catgagttaa tggaaattct acctttacag
     1081 tattgtttcg gtatcttctc tgtccccgaa attggctatt tcattgtctt cgctgctgtt
     1141 ttctctttgt tggtcctcct gctccgtccg tgacaggtgc cataaatatt attatgaaag
     1201 gatgatgact tcagggcgct acttcttcta ttctcgctac gctgctttcc ttggtcggtg
     1261 agttctttac ctcgatgatt acttggatgg gtcagctcat tgatttctat gagtctcagc
     1321 ccattctcct tgtcttcgtg attctcacta tcgcgggcat tgttctccgt atccttcgcc
     1381 gctggattcc tggtcgctcc taacgactga gagaaaacgc cgccgaccat tttaatggtc
     1441 ggcgacgttt tcttatttag aaaggattat ttgttatgct ttatggtatt cttatctttt
     1501 gcgtttgctg gctttttgtt tatatcgata actattgcaa aaatccctac aagctcgaag
     1561 ctgttgttgg ttctaaaggt tctggcaagt ctctgtatat gtctcgcgtt gctgataagt
     1621 ggcttcgttc tagtaagggg tttatttata gcaatatggg tattggttat gatttagagc
     1681 cggaatattg gaaacagacc tttgcccctg attcccttat tcttattgat gagataggcg
     1741 tgctccactc taaccgtgat tttaaggcta tgccccgtga agctgtcgag tttttcaaga
     1801 tgcagcgcaa atatcacttg acaatagttg tatcgtctca gaccatggac tttgataaaa
     1861 agattcgtga cctctgtgat cgcatttatc tctgcaatcg tattggctgg ttttgtcgcc
     1921 tcacccctta tcgctcctgt atcgctatgg aacaccgtcc cgagggcggc caagagcttg
     1981 ttaacacggt gcgcaaggcg ggcagggcta agtggtatac tatccccaag tctgtgaagc
     2041 aggtgagtgc cttagaatat gatacagagc aggttatcag caagaccccc tcgaagtaaa
     2101 aaaaaaaaac tccccgtgcc cccgtagggg gttaggggag tttttttttt tttttttttt
     2161 tactggagca ctcccgccgt cttgtcacgc gatagcgtct ccaccgcgtc ccccgtcccc
     2221 gcgagggcaa agccctcgcc cttcccaaac agaccggtag gggcttccga tacgtactga
     2281 ctgccgtgac gatgggaacg tgggcgtgcg tgtaatacgc ccacgaaatt taaatttcct
     2341 cttgacaact cattcatact gtggtaatat ttagccatgg aaatgaaagg tggttttctc
     2401 gtatgaaaac ggttgttaaa cttgattatg ctacgttcgc ctttgagcaa ggttcaattt
     2461 ctattcccaa aatcgaagat gcgcttgctc agtgtgattt acattttgca cagatatcta
     2521 acgcaagtga gaattccccc tacaattccc ctgcgggact cttctttaag cctaacaacg
     2581 gcgcgaaaca gtctccgcac tctttacaag tgtctggtca tggttgtgag cttttccgct
     2641 ctaccttgcc tcggctcgcg tccttgatgc aggaaggtca cgaattcggt cacttttctc
     2701 gtcttgactt ttgctttgat gttgttatga caaaactacg gtggcgtgag ttttatttgg
     2761 gtgttatctc tgcttccgtc gatgagatga ataatcccga aaaagcccgt aaggttcgca
     2821 aattcatgta tcagggctat ggtgattcca ctaccgttta tatcggtcgc agaaagtctt
     2881 ctgctgtctt ctgccgtatt tataataagt ctctgcaaga ccctgaaaaa aagctctgtg
     2941 cggcttctgg tgagcttctg gactgccctg atgattctta tattattcgt tatgagatgg
     3001 agttaaaatt tacttctcgt gtgaattctt ttggccgtac cgtttatgac ccctctcccc
     3061 tcttttggca gtattacgaa gaccctgata agctcttcgc ctatctccgt aaagtctgga
     3121 atcgttacgg aaatgatact cttctccctg acggctggga agatatgcag ttcgttactg
     3181 atatcgaagc tcgcaacatt cagtttacta agggtttatt tcgtcccctt agtaatgacc
     3241 ttgctcaaaa gttttctgtt tctatccata ctgaagaaca aaaaatgtct tatgttgcta
     3301 atacctttgg tcatcgtatc attgatattt tgctttatcg tcctgagctg cttttcctcg
     3361 cttgttgcaa gtgggagcag ttttataatg agtgtcttcc gttctctcct ctggcgctga
     3421 ctcaagtagt cgctcagttc tctgagtctt cccgcattgc cgttgaggaa ttccgtgaag
     3481 ttgctgatga cccctctccc tttagtgaag atgggtttga tgatatatct ttattctgat
     3541 gaaaggattg ttgctttgtg aaagttactg tagttggtaa gtcccaccgc gctggtacat
     3601 ctaagcaggg caaagactat gatttttcta ctctcatggc cgaatattcg atgcgtgcaa
     3661 atgatgacaa tgatggcgtg caggttgata gaatcaatgt tgacgctcgc atgatgccgt
     3721 atgcgctcat tgtcgttggc gctacgtatg accttgactt tgaccgtaac ggatatcttc
     3781 tcggaattga ggaagtctaa ctccctttgt tcaaacctaa atttcatttc ctatgggaga
     3841 gcggttcgcc gctctcacat ggcggggtag tgcaatggtc gcatgtcact ctctgaaggt
     3901 gaagctgctg gttcgaatcc agaccccgca accaaaacgg atttgacctc cgttattcga
     3961 tgtcgcgaaa ggtggtggcg aagtgatgaa aaagcatcgg tgtttttata agcgtttcgc
     4021 cgcccttctc gcgtctttga tggtttcttt ttccttgtgt actccttgtt ttgctggatt
     4081 tgactctgaa gctgatatgc catctttgga tgatttctat actcatcatg gttcatggtt
     4141 tgtttggcgt agtgctacta tttctggctt tcctttttat gagttgcttt gctctcctat
     4201 tactgtttct ggcactactt attctctgcc ttattcggtt tcttattcta ctaatgcgtt
     4261 tgatgtttct tatttagcta acgattctgg caaatcttat gattatgctt gcgcttttcc
     4321 tcttcctctt cgtggtgctt ctggttattg gtatgaacta ccttctttcc ctattggttc
     4381 gggaatgaag tttgatacgt gctctgttcg cgtttattct accgctgctc aaccttctgg
     4441 gacttatggt tttttaactt cttcctttag tcgctcagac cgcattcttt ctttcggtaa
     4501 cactgcctct tcttcttctg gttcttctac tgatacttta gattctttta gtttttcttc
     4561 tcctttttat tcgtatcctt ttgcaattcg ttctacttct tcttcttccg caagtggtta
     4621 tgttttacag ggtggtgaca ataattttat tattccttcg cctggctatt cgagtacccg
     4681 tgctttgaat cttggtgtta ctcgttatct tcgcggaact aatgcttttg tcccttatcc
     4741 gtctggatac actatcccct cttctgatat cggttttgtt tttgttcagc agccatcttc
     4801 ttctcctgtt tattctgctt ctgcctttga tactacaggt tctttcgctt tttctcttct
     4861 tgttcctgct tctcgtctcc ctgacgttaa gcttggtgac tggctgtccg attctccgga
     4921 ggatttgcaa gatgctatta ccaatgaatt tggagttgat tccggtactc ttaaagactc
     4981 taaggataac ttgaattctt g
//