From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human immunoglobulin germline lambda-chain gene variable region
Date: 29 Dec 92 19:58:06 GMT
Distribution: bionet
Checksum: 10151 4

LOCUS       HUMIGLVIII   1068 bp ds-DNA             PRI       10-DEC-1992
DEFINITION  Human immunoglobulin germline lambda-chain gene variable region
            (subgroup III), 5' end.
ACCESSION   M94115
KEYWORDS    germline; immunoglobulin lambda; immunoglobulin light chain;
            variable region; variable region subgroup lambda III.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Daley,D.M., Peng,H.-q., Misener,V., Liu,X.-Y., Chen,P.P. and
            Siminovitch,K.A.
  TITLE     Molecular analysis of Human immunoglobulin Vlambda germline genes:
            Subgroups Vlambda III and Vlambda IV
  JOURNAL   Mol. Immunol. 29, 1515-1518 (1992)
  STANDARD  full automatic
COMMENT     Reference [Mol. Immunol. (1992) In press] reports bases 85 through
            716.
FEATURES             Location/Qualifiers
     misc_feature    143..924
                     /note="This feature applies to a gene which lacks a coding
                     region feature. "
                     /gene="IGLV"
     sig_peptide     join(143..188,626..636)
                     /gene="IGLV"
                     /codon_start=1
     promoter        41..48
     TATA_signal     74..80
     intron          189..625
     mat_peptide     637..>924
                     /standard_name="V_region"
                     /product="immunoglobulin lambda-chain"
                     /gene="IGLV"
                     /codon_start=1
                     /citation=[1]
                     /note="subgroup III; putative"
     iDNA            925..>1068
     misc_recomb     927..933
                     /standard_name="heptamer recombination signal"
                     /citation=[1]
                     /note="putative"
     misc_recomb     957..965
                     /standard_name="nonamer recombination signal"
                     /citation=[1]
                     /note="putative"
BASE COUNT      227 a    290 c    299 g    252 t
ORIGIN      
        1 tctagaggat ctcctccagc agcagcctct gactctgctg atttgcatca tgggccgctc
       61 tctccagcaa ggggataaga gaggcctggg aggaacctgc tcagtctggg cctaaggaag
      121 cagcactggt ggtgcctcag ccatggcctg gaccgttctc ctcctcggcc tcctctctca
      181 ctgcacaggt gatcccccca gggtctcacc aacctgccca gcccaagggt tctgggtcca
      241 gcgtgtcctt gattctgagc tcaggagggc ccttcctgtg gtggcaggat gctcatgacc
      301 ctgctgcagg gtgggaggct ggtggggctg aactcccccc aaactgtgct caaaggcttg
      361 tgagagcctg agggactgca cctgccagga gagagtagtg agttttcagt tcaaagtctc
      421 catacaacag gaaagtcatg ggccactggg gctggggctg attgcagggg ataccctgag
      481 ggttcacaga ctctctggag cttgtctggg acagcagggc aagggatttc ataagaagca
      541 tctttcacct gcaagccaac ctctctctca tttatttatt tatttattta tttatttatt
      601 tatttattta tttttatctt tgcaggctct gtgacctcct atgtgctgac tcagccaccc
      661 tcggtgtcag tggccccagg aaagacggcc aggattacct gtgggggaaa caacattgga
      721 agtaaaagtg tgcactggta ccagcagaag ccaggccagg cccctgtgct ggtcgtctat
      781 gatgatagcg accggccctc agggatccct gagcgattct ctggctccaa ctctgggaac
      841 acggccaccc tgaccatcag cagggtcgaa gccggggatg aggccgacta ttactgtcag
      901 gtgtgggata gtagtagtga tcatcccacg gtgacacagg cagatgagga agtgagacaa
      961 aaacaccctc ccagcctcgg tcaccctctt gcttcagccc gggaagcctg ttgataaagc
     1021 catgagtgaa tctggcccag ttcacctgga tctgagcctt tcaggttg
//