From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human (clone lambda CGM35) pregnancy-specific beta-1-glycoprotein
Date: 31 Dec 92 01:37:35 GMT
Distribution: bionet
Checksum: 53905 8

LOCUS       HUMPBG2      2749 bp ds-DNA             PRI       17-DEC-1992
DEFINITION  Human (clone lambda CGM35) pregnancy-specific beta-1-glycoprotein
            (alternatives C3, C1 and C2) (PSG1) gene, exons IIA, IIB, C3, C2,
            and C1 and 5'end cds.
ACCESSION   M22312
KEYWORDS    Alu repeat; alternative splicing; glycoprotein;
            pregnancy-specific beta-1 glycoprotein.
SEGMENT     2 of 2
SOURCE      Homo sapiens placenta DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Oikawa,S., Inuzuka,C., Kosaki,G. and Nakazato,H.
  TITLE     Exon-intron organization of a gene for pregnancy-specific
            beta-1-glycoprotein, a subfamily member of CEA family: Implications
            for its characteristic repetitive domains and c-terminal sequences
  JOURNAL   Biochem. Biophys. Res. Commun. 156, 68-77 (1988)
  STANDARD  full automatic
COMMENT     Draft entry and computer-readable sequence [1] kindly submitted by
            S.Oikawa, 20-JAN-1989.  Exon C1,C2 and C3 may be produced by
            alternative splicing.
FEATURES             Location/Qualifiers
     prim_transcript <1..2014
                     /gene="PSG1"
                     /note="C3 mRNA and introns"
     prim_transcript <1..>2741
                     /gene="PSG1"
                     /note="C1/C2 mRNA and introns"
     intron          <1..186
                     /number=IB
                     /gene="PSG1"
     exon            187..465
                     /number=IIA
                     /gene="PSG1"
     intron          466..864
                     /number=IIA
                     /gene="PSG1"
     exon            865..1119
                     /number=IIB
                     /gene="PSG1"
     intron          1120..1474
                     /number=C3
                     /gene="PSG1"
     intron          1120..2075
                     /number=C1
                     /gene="PSG1"
     intron          1120..2161
                     /number=C2
                     /gene="PSG1"
     exon            1475..>1512
                     /number=C3
                     /gene="PSG1"
     misc_feature    1843^1844
                     /note="Alu family insert site"
     exon            2076..>2092
                     /number=C1
                     /gene="PSG1"
     exon            2162..>2172
                     /number=C2
                     /gene="PSG1"
     CDS             join(187..465,865..1119,2076..2092)
                     /gene="PSG1"
                     /partial
                     /note="C1 alternate"
                     /product="pregnancy-specific beta-1-glycoprotein"
                     /codon_start=3
                     /translation="KLPKPYITINNLKPRENKDVLNFTCEPKSENYTYIWWLNGQSLP
                     VSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYP
                     SFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTKHSGLYACSVR
                     NSATGKESSKSMTVKVSDWTLP"
     CDS             join(187..465,865..1119,2162..2172)
                     /gene="PSG1"
                     /partial
                     /note="C2 alternate"
                     /product="pregnancy-specific beta-1-glycoprotein"
                     /codon_start=3
                     /translation="KLPKPYITINNLKPRENKDVLNFTCEPKSENYTYIWWLNGQSLP
                     VSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYP
                     SFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTKHSGLYACSVR
                     NSATGKESSKSMTVKVSEAL"
     CDS             join(187..465,865..1119,1475..1512)
                     /gene="PSG1"
                     /partial
                     /note="C3 alternate"
                     /product="pregnancy-specific beta-1-glycoprotein"
                     /codon_start=3
                     /translation="KLPKPYITINNLKPRENKDVLNFTCEPKSENYTYIWWLNGQSLP
                     VSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYP
                     SFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTKHSGLYACSVR
                     NSATGKESSKSMTVKVSAYSSSINYTAVY"
BASE COUNT      812 a    623 c    548 g    766 t
ORIGIN      About 1500 bases after segment 1.
        1 cagctggcct catagtcttt gagcccttag atcatcatgc atctgtcttg tgacacacgc
       61 accagctatt ggctttcaag gactcgggtg ggctgagaag tgggagatgc caactctgat
      121 tgaaggatgc ctgtggagga atcaaaggtg ccacacagga caatcttctc tctgttatcc
      181 acacagcgaa gctgcccaag ccctacatca ccatcaacaa cttaaaaccc agggagaata
      241 aggatgtctt aaacttcacc tgtgaaccta agagtgagaa ctacacctac atttggtggc
      301 taaatggtca gagcctcccg gtcagtccca gggtaaagcg acccattgaa aacaggatcc
      361 tcattctacc cagtgtcacg agaaatgaaa caggacccta tcaatgtgaa ataagggacc
      421 aatatggtgg catccgcagt tacccagtca ccctgaatgt cctctgtgag tatcttttgt
      481 tcctctgtgg gccaggacac cagcttaaat caaaacgacc agaggccagg cctctcactc
      541 tctctctggt ccaagtatag acaccttcac ttctggacat ccgagctggc catgactccc
      601 tgccctggga aaacctgggt aggcacagct taaccaagag tataagggga gtggacgctc
      661 ttgtcatggg agacttgggg cccacagctt gtgatgggag aaacaggtga atacctcagg
      721 attcggctca gtgaacatag agggggttgg gctgggactt gagggtgtgt cttggctcag
      781 agggtcactg tgtcccttta agagaccagg aacatcccct tccctcagat gacatcacct
      841 gtggctttat tctctttgct ccagatggtc cagacctccc cagaatttac ccttcattca
      901 cctattaccg ttcaggagaa gtcctctact tgtcctgttc tgcggactct aacccaccgg
      961 cacagtattc ttggacaatt aatgggaagt ttcagctatc aggacaaaag ctctttatcc
     1021 cccaaattac tacaaagcat agcgggctct atgcttgctc tgttcgtaac tcagccactg
     1081 gcaaggaaag ctccaaatcc atgacagtaa aagtctctgg taagcggatc ccagtatcct
     1141 tggcaatagg gatttaggtg gagtctatct ggccttcagg gaagagtcag gaaaacattt
     1201 ttattcccag cctgcgtccc atgggcacaa gcaaatccca aattctcctc ctaaaccctc
     1261 caaatttgtc taagaacttt gaaaacttta acaaacaggc tgatatcttc ataaaattcc
     1321 cagcctagac caagcaggaa aaacattgat ttcaatgaaa taattgataa taatgaggat
     1381 aatgttttta tgattttcat ttgaaaattt gctgattctt taaatggttt gttttctaca
     1441 ttgacggaat ttttctcttt taacctatct gtagcttata gcagttcaat aaactatacc
     1501 gcagtttatt gaactgtaat tgaaatattt acttttgctt tctacctgac tgccccagaa
     1561 ttgggcaact attcatgaga attgatatgt ttatggtaat acacatattt gcacaagtac
     1621 agcaacaatc tgctctcttt gtaacaggac acatttcaaa tcattggtta tattaccaag
     1681 gctttgactg ggatgttata tttaaggata tagatagaat gaaccagtat gaactgcagg
     1741 caaagtctga agtcagcctt ggtttggctt cctattctca agagttttgt aaaagtttaa
     1801 tctcagattc cttataaaaa cttagagaaa agaaaatttt aaaagagagc ctacacggtc
     1861 cattgctact cttgctgcac ttatgtaaac aatcagacca cgtttgaaga aactcaacct
     1921 attttgcaaa caaacttatt ctactgaaat tatcattggt aaaactagag atgcccatag
     1981 agagaaaaat tatgtggaaa ataaaaactg tagtacacct gttatgagat tgcatctctg
     2041 ttcattgttt ctgtgttttt attatccacc tgtagactgg acattaccct gaattctact
     2101 agttcctcca attccatttt cttccatgga atcgctaaga aaaagaccca ctctgttcca
     2161 gaagccctat aagctggagg tggacaactc aatgtaaatt tcatgggaaa acccttgtac
     2221 ctgaagcgtg agccactcag aactcactaa aatgttcgac accataacaa cagatgctca
     2281 aactgtaaac caggacaata agtggatgac ttcacactgt ggacagtttt tcccaagatg
     2341 tcagaacaag actccccatc atgatgaggc tctcacccct cttaactgtc cttgctcatg
     2401 cctgcctctt tcacttggca ggataatgca gtcattagaa tttcacatgt agtagcttct
     2461 gagggtaaca atagagtgtc agatatgtca tctcaaccca aacttttaca taacatctca
     2521 gggggaaatg tggctctctc caccttgcat acaggactcc caatagaaat gaacacagag
     2581 atattgcccg tgtgtttgca gataagatgg tttctatgaa gaggtaggaa agctgaaatt
     2641 ataatagagt cccctttaaa tgcacattct gtggatgtct cgccatttcc taagagatac
     2701 attgtaaaat gtgacagtaa tactgattct agcagaataa aacatgtac
//