From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse MHC class II H2-IA-alpha gene (d haplotype) mRNA, complete
Date: 5 Jan 93 06:47:59 GMT
Distribution: bionet
Checksum: 62804 4

LOCUS       MUSMHIAAD     978 bp ss-mRNA            ROD       04-JAN-1993
DEFINITION  Mouse MHC class II H2-IA-alpha gene (d haplotype) mRNA, complete
            cds.
ACCESSION   K01923
KEYWORDS    antigen; cell surface glycoprotein; class II gene; glycoprotein;
            histocompatibility antigen; integral membrane protein;
            major histocompatibility complex.
SOURCE      Mus musculus (strain BALB/c, sub_species domesticus) spleen cDNA to
            mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Benoist,C.O., Mathis,D.J., Kanter,M.R., Williams,V.E.II. and
            McDevitt,H.O.
  TITLE     Regions of allelic hypervariability in the murine A-alpha immune
            response gene
  JOURNAL   Cell 34, 169-177 (1983)
  STANDARD  full automatic
COMMENT     The protein domains are as follows: first external protein domain
            (D1) at bases 93-356; second external protein domain (D2) at bases
            357-638; connecting peptide, transmembrane region, and cytoplasmic
            tail (CP,TM,C) at bases 639-791. [1] also sequenced the IA-alpha
            genes from mice of b,f,u and q haplotypes.
FEATURES             Location/Qualifiers
     mRNA            <1..>978
                     /note="IA-alpha mRNA"
     sig_peptide     24..92
                     /gene="MHC H2-IA-alpha"
                     /codon_start=1
     mat_peptide     93..791
                     /gene="MHC H2-IA-alpha"
                     /codon_start=1
     CDS             24..794
                     /gene="MHC H2-IA-alpha"
                     /codon_start=1
                     /translation="MPCSRALILGVLALNTMLSLCGGEDDIEADHVGFYGTTVYQSPG
                     DIGQYTHEFDGDELFYVDLDKKKTVWRLPEFGQLILFEPQGGLQNIAAEKHNLGILTK
                     RSNFTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVY
                     ETSFLVNRDHSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTE
                     TVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL"
BASE COUNT      220 a    263 c    245 g    250 t
ORIGIN      44 bp upstream of HinfI site, chromosome 17.
        1 gcagagacct cccagagacc aggatgccgt gcagcagagc tctgattctg ggggtcctcg
       61 ccctgaacac catgctcagc ctctgcggag gtgaagacga cattgaggcc gaccacgtag
      121 gcttctatgg tacaactgtt tatcagtctc ctggagacat tggccagtac acacatgaat
      181 ttgatggtga tgagttgttc tatgtggact tggataagaa gaaaactgtc tggaggcttc
      241 ctgagtttgg ccaattgata ctctttgagc cccaaggtgg actgcaaaac atagctgcag
      301 aaaaacacaa cttgggaatc ttgactaaga ggtcaaattt caccccagct accaatgagg
      361 ctcctcaagc gactgtgttc cccaagtccc ctgtgctgct gggtcagccc aacaccctta
      421 tctgctttgt ggacaacatc ttcccacctg tgatcaacat cacatggctc agaaatagca
      481 agtcagtcac agacggcgtt tatgagacca gcttcctcgt caaccgtgac cattccttcc
      541 acaagctgtc ttatctcacc ttcatccctt ctgatgatga catttatgac tgcaaggtgg
      601 agcactgggg cctggaggag ccggttctga aacactggga acctgagatt ccagccccca
      661 tgtcagagct gacagaaact gtggtgtgtg ccctggggtt gtctgtgggc cttgtgggca
      721 tcgtggtggg caccatcttc atcattcaag gcctgcgatc aggtggcacc tccagacacc
      781 cagggccttt atgagtcaca ccctggaaag gaaggtgtgt gtccctcttc atggaagaag
      841 tggtgtgctg ggtgacctgg cacagtgtgt tttctggacc aatttatggt gttctttttc
      901 ttcttcaagt gacccccaac ttgcttttcc cttggccctg aggctgtccc tctcacagct
      961 cacacaccct tggaattc
//