From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens Wegener's granulomatosis autoantigen proteinase 3
Date: 3 Jan 93 22:07:02 GMT
Distribution: bionet
Checksum: 54998 11

LOCUS       HUMWEGAUTO   6985 bp ds-DNA             PRI       21-DEC-1992
DEFINITION  Homo sapiens Wegener's granulomatosis autoantigen proteinase 3
            gene, exons 1, 2, 3, 4, and 5.
ACCESSION   M97911
KEYWORDS    Wegener's autoantigen; proteinase 3.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 6985)
  AUTHORS   Sturrock,A.B., Franklin,K.F., Rao,G., Marshall,B.C.,
            Rebentisch,M.B., Lemons,R.S. and Hoidal,J.R.
  TITLE     Structure, chromosomal assignment and expression of the gene for
            proteinase-3: The wegener's granulomatosis autoantigen
  JOURNAL   J. Biol. Chem. 267, 21193-21199 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mRNA            join(412..472,2832..2997,3256..3397,5230..5460,6619..6783)
                     /note="proteinase 3"
     exon            412..472
                     /number=1
     intron          473..2831
                     /number=1
     exon            2832..2997
                     /number=2
     intron          2998..3255
                     /number=2
     exon            3256..3397
                     /number=3
     intron          3398..5229
                     /number=3
     exon            5230..5460
                     /number=4
     intron          5461..6618
                     /number=4
     exon            6619..6783
                     /number=5
BASE COUNT     1479 a   2033 c   1954 g   1519 t
ORIGIN      
        1 accgcggtgg agtctgcatc ctgtcccctg ctacgtcctg ctgtctgtcc gtttccagct
       61 cacccaccca cgggacacac ctcgcacggc cggctttgct ggggccacag ggacctcgtc
      121 agggaggcgt ctccttgtgg gtggcacgtg gcatgtgttg ctctgaggct gtgccatgtt
      181 gcccacctgg cctccacccc gacttgggtg ggtgacagcc agcctccccg cccccacaaa
      241 ggttggacct tgagcccaaa gccccctcct cctccccgag tccgttcttg actcccaggc
      301 tcccaaggca aaaggaggaa gtggggaccc agcctgggca ttgggcaact caacgccgtc
      361 tggcattggc tataagagga gcttgaccgt gggtgcaccc tggaccccac catggctcac
      421 cggcccccca gccctgccct ggcgtccgtg ctgctggcct tgctgctgag cggtgagtga
      481 gccacgtgcc catccatcca gcctccaggc cggtggattg tggggaaata tccaccacga
      541 ggtcatcaaa gcccttctgg cacagctggg aaactgaggc agggtcaggg gagactcact
      601 cactgctcgg gaccaacgtt gcaggggtgg ggaggacaag ggcaaggggg agcctgcatt
      661 tgactcagtt gcctatctgt aaaacgggca aaacccagcc cttccctcct gaggagctgt
      721 tttgggaatt agctagtaac aggcgaattc ctggacagca cccagccttc agcaaatgct
      781 cagtgaatat gcatgaatga atgaatgagt gaatgaatga gtgagtgagt gaatgagtga
      841 acaaatgaat gagtgaatga atcaatgagt gagtgaatga atgagtgaat gagtgaatga
      901 gtgaacgaat gaatgagtga atgaatcaat gagtgagtga atgaatgagt gaatgagtga
      961 atgaatgagt gaatgagtga atgagtgaac gaatgaatga gtgaatgaat gaatgagtga
     1021 gtgagtgaaa gggtcgagga gttagtgatg ctggaatcag gggaagaaga gagcatgggc
     1081 cccctcaggt cctatcctga ggtgattttc tttttctttt tctttttttt ttttttgaga
     1141 cggacgtccc tgatcgccca ggctggagtg cagtggcgca tcggctcact gcaagctcag
     1201 cctcccgggt tcacgccttt catcctgccc tcaagcctcc gagtagctgg ggactacagg
     1261 ccccaccacc atgcctgata attttttgta atttttgata gagacggggt ttcaaggtgt
     1321 tagccaggat ggtctcgatc tcctgacttc gtgatccgcc tgcctcagcc tcccaaagtg
     1381 ctgggattac aggcgtgaca gccgcgcctg gccctttttt tttctttttt gaaacggaat
     1441 cttgctctgt cgcccaggct ggagtgcagt ggtgcaatct cagtttactg cagcctcagc
     1501 ctcctggggt caaatgattc tcctgcctcc gcctcttgag tagctgggat tacaagcaca
     1561 caccaccaca cctggctagt ttttgtattt ttagtagaga tgggtttcac cacgttggtt
     1621 caggctggtc tcgaactcct gacctgaggg ggattttcaa tgcctcagtt tgttcatctg
     1681 caaaatgggt ctctttgttg gctgattttt tttttttttt ttcgtttttt tttattttgt
     1741 tttgttttgt ttttttgaga tgggtctcac tcagcatgag ccacgcgccc aggatttttt
     1801 tttttttttt tttttttttg agacagaatc tcactctgtt gcccaggctg gagtgcagtg
     1861 gtgtgatctc ggctcactgc aacctgtgcc tcctgggttc aagcgattct cctgcctcag
     1921 cctcccaggc agctgagatt acatgcgaac caccacacct ggctaatttt tttttttttt
     1981 tttttgaaga cggagtgtca ttctgttgcc aggctggagt gcagtggggc gatcttggct
     2041 caccacaacc tccgcttcct gggttcaagc gattctcctg cgtcaactcc ggagtagctg
     2101 ggactacagc acgtgccacc atgcccagct aatgtttgta tttttagtag aggacagggt
     2161 ttcaccatgt tggccaggat ggtctccatc tcttgacctc gggtgatcca cccacctcgg
     2221 cctccaaagt attgggatta caggcgtggg ccaaccgcac ccgaccaatt tttctgcttc
     2281 tttaaaaaca tttttttaaa ttttgtttta gagacagggt cttgctctgt tgcccaggct
     2341 ggagtgcagt ggtgtgatct cagttcactg cagccttgac ctcctgggct caagcgatcc
     2401 tccctcctca gcctcccaag tagctgggag acaggtgcac accaccatgc ctggctaatt
     2461 ttaaaatttt ttgtagagat ggggtcctca caattttgcc caggctggtc ttgaactcct
     2521 gagctcaagg gagcctcctg cctcggcctc ccaaagtgtt gggattcagg cgtgagccac
     2581 tgcacccagc cacctggtct gcgtcttaaa gccttctact ctcaggactg aaagctgcca
     2641 ccagggcgcc tttggaaatc gtcgtaatta taaccccccc ggcctgggcg cgtagacctt
     2701 cccaccacca gcaggcactg accgggttgc agatcgggag acggaggctc ggagaggccc
     2761 agggctcgtc tgccatcccc cctttccctg cagcctgggg gctccctgac gcctggactc
     2821 cccccctgca ggtgctgccc gagctgcgga gatcgtgggc gggcacgagg cgcagccaca
     2881 ctcccggccc tacatggcct ccctgcagat gcgggggaac ccgggcagcc acttctgcgg
     2941 aggcaccttg atccacccca gcttcgtgct gacggccgcg cactgcctgc gggacatgtg
     3001 agcggcctcc acacccctgt ccgcccgccc cgccctcttc tccagccctg gcccggccac
     3061 tgtccctctg cccggggagg acccagctaa gccccgtctg cagaccccag gccgcgcgcg
     3121 tgggcagttc tgggggaggc ccgggacggg tcgccgaggg aggggtctgg ggctgcaccg
     3181 cggcctcggg aagggccggc tgtgggcggc ggcgagtgtc cagggcgccg aggagtgacc
     3241 accccacccc cgcagacccc agcgcctggt gaacgtggtg ctcggagccc acaacgtgcg
     3301 gacgcaggag cccacccagc agcacttctc ggtggctcag gtgtttctga acaactacga
     3361 cgcggagaac aaactgaacg acattctcct catccaggtg ggcgggcagg gcgagggctc
     3421 ggaggggcac ggcagaggga cccccattcc tgcagccagc attcattgag cacccactgt
     3481 ataccgggcc acgaccgagg cagctgcagc tggccagtgg cactgccggg ggagaccgct
     3541 ccttggacac caggccactc ctcctccccg cctctccccc gcgcgcgcct ctccccgccc
     3601 gcgcctctcc cctgacctga cccctctccc ctgcctagcg cctccgcccg gtgtgctgtt
     3661 cccccagaaa gccaggtgcc ctcgcctctc tccggcgcct cccctgacct cactggaagt
     3721 ggcgaggaca gccacagccc tccccgattc actgttctcc actgaaccgc gtgctcctct
     3781 cattcatggg gcctcaaatg tccttagtcc acccagaaag acatccccag ggcagaggat
     3841 ttttgtctgt gttgttcgtt attggactca tgtggcttag aacgggactg ggcatacagg
     3901 tggtgctcag taagtgcttg gggctgggca ctgtggctca cgcctgtact cccagtactt
     3961 tgggaaggct gggatgggag gatcacttga ggccaggagt ttgggagcag cctgaccaac
     4021 ctagtgagac cccatctcta taaaagacat tttttttttt ttttttttag acagagtctc
     4081 actcagtcat ccaggctgga gtgcagtggt gcaatctcgg ctcactgcca cctctgcctt
     4141 ccaggttcaa gtaattctcc tgcctcagcc tcctgagtag ctgggattac aggcatgcac
     4201 caacacgctt ggctaatttt tgtattttta gtagagacgg tgttttgcca cgttggccag
     4261 gctggtctcg aactcctgac ctcaagtgat ctgctctcct cagcctccca aagtgctggg
     4321 attataggag agagccaccg cgtccagcct acaaaagaaa aatttaaaac tcaaccgggc
     4381 taggtagcac gcgccaagcc actcatgagc tgagatggga ggatcacttg agcccaggag
     4441 gttgaggctg cagtgagctg tgatcatgcc accacactcc agcctcgcgc agagcaagac
     4501 cccatctcaa aaaaaaagtg ctttgaagat gaatgaatgg gccaggcggt ggctgtaatc
     4561 ccagcacttt gggaggccga ggcgggcgga tccgtgaggt cggagtttga gaccagcctg
     4621 atcgatatgg caaaccccgt gtctactaaa atacaaaatt agctgggcgt gacggcaggt
     4681 gtctgtagtc ccagctactt gggaggctga ggcagcagaa ttgcttgaac ccaggaggca
     4741 gaggttgcag tgagccgaga ttgtgccact gcatctagcc tgggcaacaa gagcgaaact
     4801 ccatctcaaa aaaaaaaaaa agaaaagaaa gaaagaaaga aaacatgaat gaatggccgg
     4861 gcactatggc tcacacttgt aatcccagca ctttcggagg ctgaggaagg cagatcactt
     4921 gaggttggga gtttgagacc aggctggcac ctcacccaat ggatggctcc ggaggttcca
     4981 gtgagccgag atcacgccac tgcattccag cctgggtggc agagcaagac tccatctcaa
     5041 aagaaagaaa gaaggaaaga aaatgaatga atacaatagt gacaaatggg acaaaggggg
     5101 tcgtggggcc caggcggagg gacggatccg cggcgttttg aggtggtggg tgtggtgggt
     5161 gtggtgggag gcgcgggcgg ccaccgtgac ctggaagcag tgctcaccgc cgcctgcctt
     5221 ctgccccagc tgagcagccc agccaacctc agtgcctccg tcacctcagt ccagctgcca
     5281 cagcaggacc agccagtgcc ccacggcacc cagtgcctgg ccatgggctg gggccgcgtg
     5341 ggtgcccacg accccccagc ccaggtcctg caggagctca atgtcaccgt ggtcaccttc
     5401 ttctgccggc cacataacat ttgcactttc gtccctcgcc gcaaggccgg catctgcttc
     5461 gtaagtaacc gtgcccccac cccggccagg cgtgccatga ggggaggagg gcggcggcag
     5521 ggttccacgc cacctcttag ctgtggcttc atgctgtgcc tcagcttccc cacctggaag
     5581 cacacccaac acccaacggg caggctcagc ggggtggggg cgctcacatt gcacctggct
     5641 gcttgggtgg gtctgggttc cctgcccccc actcccctct aggaccacag gaaggtgtgg
     5701 gagacccacc tcacggcggc cccttccaga atccaggact ccaggtatcc agcggaggcc
     5761 cataaatgcc cagttccatc gaaagacctc agcccctccc tgctcacagt ttttgtttgt
     5821 ttttgagacg gagtgtcgct ctgttgtcct ggctggagtg cagtggtgag atctcagctc
     5881 actgcaacct ccgcctccag gtcaaggtat tctcctgcct cagcctctga gtaactaggg
     5941 cacaggtacc tgcccaccaa cacgctggct aatttttgta tttttagtag agacggtgtt
     6001 ttgccacgtt ggccaggctg gtctcgaacc tctgacctca agtgatctgc tctcctcagc
     6061 ctcccaaagt gctgggatta taggagagag ccaccgcgtc cagcctacaa aagaaaaatt
     6121 taaaaatcaa ccgggcatgg tagcacacgc caagccactc atgagctgag atgggaggat
     6181 cacttgagcc caggaggttg aggctgcagt gagctgtgat catgccacca cactccagcc
     6241 tgggtgacag agcgagactc tgtcgcaaac aaaacaaaaa caaaacaaaa caaaacaaaa
     6301 ggagaagaag aagagtagag agagaaagaa agaagaaaga aagaaaaaga gagaaagaaa
     6361 gaaagaaaga aagaaaaaga aagagagaga gagagagaga gagagagaaa gaaagaaaga
     6421 aagttccata ttggaagcat ttttattctg aaacagctgt gcatccccca gcccccttcc
     6481 tgctgcctgg ccagcccggg tgactggctg tccccatctc ccgggagact caggtggccc
     6541 tgatggtgac tggccgtccc catcctccag ggagactcag gtggccctga tgggtgactg
     6601 gccgtccctg tcctccaggg agactcaggt ggccccctga tctgtgatgg catcatccaa
     6661 ggaatagact ccttcgtgat ctggggatgt gccacccgcc ttttccctga cttcttcacg
     6721 cgggtagccc tctacgtgga ctggatccgt tccacgctgc gccgtgtgga ggccaagggc
     6781 ccctgaaccg cccctcccac agcgctggcc gggaccccga gcctggctcc aaaccctcga
     6841 ggcggatctt tggacagaag cagctcttcc ccgaacactg tggcgtccgg gccccacccg
     6901 tccccccaca ctccctccac ggggctccgg gagacaggcc ggccctgcac ctcaccccac
     6961 cgtgacctaa ataaacgttg aaact
//