From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: C.domesticus gene for proteolipid protein
Date: 11 Sep 92 10:03:17 GMT
Distribution: bionet
Checksum: 03656     4

LOCUS       DOGPLP       1173 bp ds-DNA             MAM       11-SEP-1992
DEFINITION  C.domesticus gene for proteolipid protein
ACCESSION   X55317
KEYWORDS    myelin protein; proteolipid protein.
SOURCE      Canis domesticus DNA.
  ORGANISM  Canis domesticus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Carnivora; Caniformia; Canoidea; Canidae.
REFERENCE   1  (sites)
  AUTHORS   Nadon,N.L., Duncan,I.D. and Hudson,L.D.
  TITLE     A point mutation in the proteolipid protein gene of the 'shaking
            pup' interrupts oligodendrocyte development.
  JOURNAL   Development 110, 529-537 (1990)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 1173)
  AUTHORS   Nadon,N.L.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     *source: clone_library=genomic EMBL3; *source: chromosome=X;
            From EMBL    entry CDPLP;  dated 27-AUG-1992.
FEATURES             Location/Qualifiers
     exon            1..113
                     /number=1
     CDS             110..943
                     /product="proteolipid protein (PLP)"
                     /codon_start=1
                     /translation="MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTE
                     KLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFG
                     DYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALT
                     IVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGK
                     VCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTK
                     F"
     exon            114..300
                     /number=2
     exon            301..562
                     /number=3
     exon            563..731
                     /number=4
     exon            732..805
                     /number=5
     exon            806..871
                     /number=6
     exon            872..>1173
                     /number=7
BASE COUNT      257 a    302 c    285 g    329 t
ORIGIN
        1 agaggaccga agaaggagac tggagagacc aggatccttc cagctgaaca aagtcagcag
       61 caaagcagac tagccagctg gctacaattg gagtcagagt tccaaagaca tgggcttgtt
      121 agagtgctgt gcaagatgtc ttgtaggggc cccctttgct tccttggtgg ccactggatt
      181 atgtttcttt ggggtggcac tgttctgtgg ctgtggacat gaagcattaa ctggtacaga
      241 aaagctaatt gagacctatt tctccaaaaa ctaccaggac tatgagtatc tcatcaatgt
      301 gatccatgcc ttccagtatg tcatctatgg aactgcctct ttcttcttcc tttatggggc
      361 cctcctgctg gctgagggct tctacaccac cggtgcagtc aggcagatct ttggcgacta
      421 caagaccacc atctgcggca agggcctgag cgcaacggta acagggggcc agaaggggag
      481 gggttccaga ggccaacatc aagctcattc tttggagcgg gtgtgtcatt gtttgggaaa
      541 atggctagga catcccgaca agtttgtggg catcacctat gccttgacca ttgtgtggct
      601 cctggtgttt gcctgctctg ctgtgcctgt gtacatttac ttcaatacct ggaccacctg
      661 ccagtcaatt gccttcccca gcaagacttc tgccagtata ggcagtctct gtgctgatgc
      721 cagaatgtat ggtgttctcc catggaatgc tttcccaggc aaagtgtgtg gctccaacct
      781 tctgtccatc tgcaaaacag ctgagttcca aatgacgttc cacctgttta ttgctgcatt
      841 cgtgggggct gcagccacac tggtttccct gctcaccttc atgattgctg ccacttacaa
      901 ctttgccgtc cttaaactca tgggccgagg caccaagttc tgatctcctg tagaaatgtc
      961 cctttctcta atagcgaggc tctaaccaca cagcctacaa tgctgcgtct cccatgttaa
     1021 ctctttgcct ttgccatcta ttggcccttt cttacttgac gagtgtaaca agaaaggaga
     1081 gtcttgtggt gattaatgtc tctctgtgga ctctccccct tacatacctc ttttagtcat
     1141 tttgcttcac agctggttcc tgctagaaat ggg
//