From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human platelet-derived growth factor A type receptor mRNA, complete
Date: 29 Sep 92 10:06:50 GMT
Distribution: bionet
Checksum: 22175    12

LOCUS       HUMPDGFARA   6375 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human platelet-derived growth factor A type receptor mRNA, complete
            cds.
ACCESSION   M22734
KEYWORDS    growth factor receptor;
            platelet-derived growth factor A type receptor;
            transmembrane glycoprotein; tyrosine kinase.
SOURCE      Human foreskin fibroblast AG 1518 cell line, cDNA to mRNA, clone
            phPDGFRA15.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 6375)
  AUTHORS   Claesson-Welsh,L., Eriksson,A., Westermark,B. and Heldin,C.-H.
  TITLE     cDNA cloning and expression of the human A-type platelet-derived
            growth factor (PDGF) receptor establishes structural similarity to
            the B-type PDGF receptor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86, 4917-4921 (1989)
  STANDARD  full staff_review
COMMENT     Draft entry and computer-readable sequence for [1] kindly submitted
            by L.Claesson-Welsh, 09-MAY-1989.
FEATURES             Location/Qualifiers
     mRNA            1..>6375
                     /note="PDGF type A receptor mRNA"
     CDS             129..3398
                     /product="platelet-derived growth factor A type receptor"
                     /gene="PDGFA"
                     /codon_start=1
                     /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS
                     FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY
                     NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT
                     LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM
                     EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT
                     VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH
                     FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY
                     TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC
                     KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG
                     AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS
                     PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV
                     AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL
                     VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT
                     QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF
                     TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF
                     LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR
                     MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS
                     DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE
                     EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF
                     L"
     sig_peptide     129..197
                     /gene="PDGFA"
                     /codon_start=1
     mat_peptide     198..3395
                     /product="platelet-derived growth factor A type receptor"
                     /gene="PDGFA"
                     /codon_start=1
BASE COUNT     1902 a   1297 c   1443 g   1731 t      2 others
ORIGIN      Unreported.
        1 ttggagctac agggagagaa acagaggagg agactgcaag agatcattgg aggccgtggg
       61 cacgctcttt actccatgtg tgggacattc attgcggaat aacatcggag gagaagtttc
      121 ccagagctat ggggacttcc catccggcgt tcctggtctt aggctgtctt ctcacagggc
      181 tgagcctaat cctctgccag ctttcattac cctctatcct tccaaatgaa aatgaaaagg
      241 ttgtgcagct gaattcatcc ttttctctga gatgctttgg ggagagtgaa gtgagctggc
      301 agtaccccat gtctgaagaa gagagctccg atgtggaaat cagaaatgaa gaaaacaaca
      361 gcggcctttt tgtgacggtc ttggaagtga gcagtgcctc ggcggcccac acagggttgt
      421 acacttgcta ttacaaccac actcagacag aagagaatga gcttgaaggc aggcacattt
      481 acatctatgt gccagaccca gatgtagcct ttgtacctct aggaatgacg gattatttag
      541 tcatcgtgga ggatgatgat tctgccatta taccttgtcg cacaactgat cccgagactc
      601 ctgtaacctt acacaacagt gagggggtgg tacctgcctc ctacgacagc agacagggct
      661 ttaatgggac cttcactgta gggccctata tctgtgaggc caccgtcaaa ggaaagaagt
      721 tccagaccat cccatttaat gtttatgctt taaaagcaac atcagagctg gatctagaaa
      781 tggaagctct taaaaccgtg tataagtcag gggaaacgat tgtggtcacc tgtgctgttt
      841 ttaacaatga ggtggttgac cttcaatgga cttaccctgg agaagtgaaa ggcaaaggca
      901 tcacaatgct ggaagaaatc aaagtcccat ccatcaaatt ggtgtacact ttgacggtcc
      961 ccgaggccac ggtgaaagac agtggagatt acgaatgtgc tgcccgccag gctaccaggg
     1021 aggtcaaaga aatgaagaaa gtcactattt ctgtccatga gaaaggtttc attgaaatca
     1081 aacccacctt cagccagttg gaagctgtca acctgcatga agtcaaacat tttgttgtag
     1141 aggtgcgggc ctacccacct cccaggatat cctggctgaa aaacaatctg actctgattg
     1201 aaaatctcac tgagatcacc actgatgtgg aaaagattca ggaaataagg tatcgaagca
     1261 aattaaagct gatccgtgct aaggaagaag acagtggcca ttatactatt gtagctcaaa
     1321 atgaagatgc tgtgaagagc tatacttttg aactgttaac tcaagttcct tcatccattc
     1381 tggacttggt cgatgatcac catggctcaa ctgggggaca gacggtgagg tgcacagctg
     1441 aaggcacgcc gcttcctgat attgagtgga tgatatgcaa agatattaag aaatgtaata
     1501 atgaaacttc ctggactatt ttggccaaca atgtctcaaa catcatcacg gagatccact
     1561 cccgagacag gagtaccgtg gagggccgtg tgactttcgc caaagtggag gagaccatcg
     1621 ccgtgcgatg cctggctaag aatctccttg gagctgagaa ccgagagctg aagctggtgg
     1681 ctcccaccct gcgttctgaa ctcacggtgg ctgctgcagt cctggtgctg ttggtgattg
     1741 tgatcatctc acttattgtc ctggttgtca tttggaaaca gaaaccgagg tatgaaattc
     1801 gctggagggt cattgaatca atcagcccag atggacatga atatatttat gtggacccga
     1861 tgcagctgcc ttatgactca agatgggagt ttccaagaga tggactagtg cttggtcggg
     1921 tcttggggtc tggagcgttt gggaaggtgg ttgaaggaac agcctatgga ttaagccggt
     1981 cccaacctgt catgaaagtt gcagtgaaga tgctaaaacc cacggccaga tccagtgaaa
     2041 aacaagctct catgtctgaa ctgaagataa tgactcacct ggggccacat ttgaacattg
     2101 taaacttgct gggagcctgc accaagtcag gccccattta catcatcaca gagtattgct
     2161 tctatggaga tttggtcaac tatttgcata agaataggga tagcttcctg agccaccacc
     2221 cagagaagcc aaagaaagag ctggatatct ttggattgaa ccctgctgat gaaagcacac
     2281 ggagctatgt tattttatct tttgaaaaca atggtgacta catggacatg aagcaggctg
     2341 atactacaca gtatgtcccc atgctagaaa ggaaagaggt ttctaaatat tccgacatcc
     2401 agagatcact ctatgatcgt ccagcctcat ataagaagaa atctatgtta gactcagaag
     2461 tcaaaaacct cctttcagat gataactcag aaggccttac tttattggat ttgttgagct
     2521 tcacctatca agttgcccga ggaatggagt ttttggcttc aaaaaattgt gtccaccgtg
     2581 atctggctgc tcgcaacgtt ctcctggcac aaggaaaaat tgtgaagatc tgtgactttg
     2641 gcctggccag agacatcatg catgattcga actatgtgtc gaaaggcagt acctttctgc
     2701 ccgtgaagtg gatggctcct gagagcatct ttgacaacct ctacaccaca ctgagtgatg
     2761 tctggtctta tggcattctg ctctgggaga tcttttccct tggtggcacc ccttaccccg
     2821 gcatgatggt ggattctact ttctacaata agatcaagag tgggtaccgg atggccaagc
     2881 ctgaccacgc taccagtgaa gtctacgaga tcatggtgaa atgctggaac agtgagccgg
     2941 agaagagacc ctccttttac cacctgagtg agattgtgga gaatctgctg cctggacaat
     3001 ataaaaagag ttatgaaaaa attcacctgg acttcctgaa gagtgaccat cctgctgtgg
     3061 cacgcatgcg tgtggactca gacaatgcat acattggtgt cacctacaaa aacgaggaag
     3121 acaagctgaa ggactgggag ggtggtctgg atgagcagag actgagcgct gacagtggct
     3181 acatcattcc tctgcctgac attgaccctg tccctgagga ggaggacctg ggcaagagga
     3241 acagacacag ctcgcagacc tctgaagaga gtgccattga gacgggttcc agcagttcca
     3301 ccttcatcaa gagagaggac gagaccattg aagacatcga catgatggac gacatcggca
     3361 tagactcttc agacctggtg gaagacagct tcctgtaact ggcggattcg aggggttcct
     3421 tccacttctg gggccacctc tggatcccgt tcagaaaacc actttattgc aatgcggagg
     3481 ttgagaggag gacttggttg atgtttaaag agaagttccc agccaagggc ctcggggagc
     3541 ctttctaaat atgaatgaat gggatatttt gaaatgaact ttgtcagtgt tgcctcttgc
     3601 aatgcctcag tagcatctca gtggtgtgtg aagtttggag atagatggat aagggaataa
     3661 taggccacag aaggtgaact ttctgcttca aggacattgg tgagagtcca acagacacaa
     3721 tttatactgc gacagaactt cagcattgta attatgtaaa taactctaac cacggctgtg
     3781 tttagattgt attaactatc ttctttggac ttctgaagag accactcaat ccatccatgt
     3841 acttccctct tgaaacctga tgtcagctgc tgttgaactt tttaaagaag tgcatgaaaa
     3901 accatttttg accttaaaag gtactggtac tatagcattt tgctatcttt tttagtgtta
     3961 aagagataaa gaataataat taaccaacct tgtttaatag atttgggtca tttagaagcc
     4021 tgacaactca ttttcatatt gtaatctatg tttataatac tactactgtt atcagtaatg
     4081 ctaaatgtgt aataatgtaa catgatttcc ctccacacaa agcacaattt aaaaacaatc
     4141 cttactaagt aggtgatgag tttgacagtt tttgacattt atattaaata acatgtttct
     4201 ctataaagta tggtaatagc tttagtgaat taaatttagt tgagcataga gaacaaagta
     4261 aaagtagtgt tgtccaggaa gtcagaattt ttaactgtac tgaataggtt ccccaatcca
     4321 tcgtattaaa aaacaattaa ctgccctctg aaataatggg attagaaaca aacaaaactc
     4381 ttaagtccta aaagttctca atgtagaggc ataaacctgt gctgaacata acttctcatg
     4441 tatattaccc aatggaaaat ataatgatca gcgcanaaag actggatttg cagaagttnt
     4501 tttttttttt tcttcttgcc tgatgaaagc tttggcgacc ccaatatatg tattttttga
     4561 atctatgaac ctgaaaaggg tcacaaagga tgcccagaca tcagcctcct tctttcaccc
     4621 cttaccccaa agagaaagag tttgaaactc gagaccataa agatattctt tagtggaggc
     4681 tggaagtgca ttagcctgat cctcagttct caaatgtgtg tggcagccag gtagactagt
     4741 acctgggttt ccatccttga gattctgaag tatgaagtct gagggaaacc agagtctgta
     4801 tttttctaaa ctccctggct gttctgatcg gccaggtttc ggaaacactg acttaggttt
     4861 caggaagttg ccatgggaaa caaataattt gaactttgga acagggttct taagttggtg
     4921 cgtccttcgg atgataaatt taggaaccga agtccaatca ctgtaaatta cggtagatcg
     4981 atcgttaacg ctggaattaa attgaaaggt cagaatcgac tccgactctt tcgatttcaa
     5041 accaaaactg tccaaaaggt tttcatttct acgatgaagg gtgacatacc ccctctaact
     5101 tgaaaggggc agagggcaga agagcggagg gtgaggtatg gggcggttcc tttccgtaca
     5161 tgtttttaat acgttaagtc acaaggttca gagacacatt ggtcgagtca caaaaccacc
     5221 ttttttgtaa aattcaaaat gactattaaa ctccaatcta ccctcctact taacagtgta
     5281 gataggtgtg acagtttgtc caaccacacc caagtaaccg taagaaacgt tatgacgaat
     5341 taacgactat ggtatactta ctttgtaccc gacactaatg acgttagtga cacgatagcc
     5401 gtctactacg aaaccttcta cgtcttcgtt attatttcat gaactgatgg atgaccacat
     5461 tagagttacg ttcggggttg aaagaatagg ttgaaaaagt atcattcacg cttctgactc
     5521 ggtctaaccg gttaattttt cttttggact gatccaagac atctcggtta atctgaactt
     5581 tatgcaaaca caaagatctt agtgtcgagt tcgtaagaca aatagcgagt gagagggaac
     5641 atgtcggaat aaaacaacca cgaaacgtaa aactataacg acactcggaa cgtactgtag
     5701 tactccggcc tactttgaag agtcaggtcg tcaaaggtca ggattgttta cgagggtgga
     5761 cttaaacata tactgacgta aacacccaca cacacacaaa agtcgtttaa ggtctaaaca
     5821 aaggaaaacc ggaggacgtt tcagaggtct tcttttaaac ggttagaaag gatgaaagat
     5881 aaaaatacta ctgttagttt cggccggact ctttgtgata aacactgaaa aatttgctaa
     5941 tcactacagg aattttacac cagacggtta gacatgtttt accaggataa aaacacttct
     6001 ccctgtattc tattttacta caatatgtag ttatacatat atacataaag atatatctga
     6061 acctcttatg acggttttgt aaatactgtt cgacatagtg acggaagcaa atataaaaaa
     6121 attgacacta ttaggggtgt ccgtgtaatt gacaacgtga aaacttacag gttttaaata
     6181 taaaatcttt attatttttc tttctatgaa tgtacaaggg ttttgttacc acaccactta
     6241 cacactcttt ttgattgaac tatcccagat ggttatgttt tacataatgc ttacggggac
     6301 aagtacaaaa acaaaatttt gcacatttac ttctagaaat ataaagttat ttactatata
     6361 ttaaatttcc ttaag
//