From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Hepatitis E virus genomic RNA.
Date: 12 Jan 93 05:46:24 GMT
Distribution: bionet
Checksum: 26848 14

LOCUS       HPEHEV       7194 bp ss-RNA             VRL       12-JAN-1993
DEFINITION  Hepatitis E virus genomic RNA.
ACCESSION   D10330
KEYWORDS    .
SOURCE      Hepatitis E virus (individual_isolate HEVNE8L) RNA.
  ORGANISM  Hepatitis E virus
            Viridae; ss-RNA nonenveloped viruses.
REFERENCE   1  (sites)
  AUTHORS   Tam,A.W., Smith,M.W., Guerra,M.E., Huang,C.-C., Bradley,D.W.,
            Fry,K.E. and Reyes,G.R.
  TITLE     Hepatitis E virus (HEV): molecular cloning and sequencing of the
            full-length viral genome
  JOURNAL   Virology 185, 120-131 (1991)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 7194)
  AUTHORS   Aye,T.T., Uchida,T., Ma,M.Z., Iida,F., Shikata,T., Ichikawa,M.,
            Rikihisa,T. and Winn,K.
  TITLE     Sequence and gene structute of the hepatitis E virus isolated from
            Myanmar
  JOURNAL   Virus Genes (1992) In press
  STANDARD  full automatic
COMMENT     Submitted (23-Jan-1992) to DDBJ by: Toshikazu Uchida Ist Department
            of Pathology Nihon University School of Medicine 30-1 Oyaguchi
            Kamimachi Itabashi-ku, Tokyo 173 Japan Phone:  03-3972-8111 Fax:
            03-3972-8830.
FEATURES             Location/Qualifiers
     polyA_site      7194
     CDS             28..5109
                     /product="ORF1"
                     /codon_start=1
                     /translation="MEAHQFIKAHGITTAIEQAALAAANSALANAVVVRPFLSHQQIE
                     ILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNV
                     VHRCFLLPVGRDVQRWYTAPTRGPAANCRRSALRGLPAVDRTYCLDGFSGCNFPAETG
                     IALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVV
                     VTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPM
                     PYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQA
                     FCCSRLMTYLRGISYKVTVGTLVANEGWNASEDALTAVITAAYLTICHQRYLRTQAIS
                     KGMRRLEREHAQKFITPLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLV
                     FDESAPCRCRTAIRKALSKFCCFMKWLGQECTCFLQPAEGVVGDQGHDNEAYEGSDVD
                     PAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETL
                     LGNKTFRTSFVDGAVLEANGPERYNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAA
                     GLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRHSLTGNLWFHPEGLIGLFAPF
                     SPGHVWESANPFCGESTLYTRTWSEVDAVSSPARPDLGLMSEPSIPSRAATPTLAVLL
                     PPPAPDPPPPPSAPALDEPASGATAGAPAITHQTARHRRLLFTYPDGSKVFAGSLFES
                     TCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAP
                     DYRLEHNPKRLEAAYRETCSRLGTAAYSLLGTGIYQVPIGPSFDAWERNHRPGDELYL
                     PELAARWFEANRPTRPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQF
                     TAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFNPHTAARVTQGRRVVIDE
                     APSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLGPTSWWHVTHRC
                     PADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKAANPGSVTVHEAQGA
                     TYTETTIIATADARGLIQSSRAHAIVALTRHTEKFVIIDAPGLLREVGISDAIVNNFF
                     LAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPVPVAAVLPP
                     CPELEQGLLYLPQGLTACDSVVTFELTDIVHCRMAAPNQRKAVLSTLVGRYGRRTKLY
                     NASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRI
                     TFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYG
                     DAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLIRLYH
                     LIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDFQVAAFKGDD
                     SIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLT
                     EKNWGPGPERAEQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVA
                     DGKAHFTESVKPVLDLTNSILCRVE"
     CDS             5106..5477
                     /product="ORF3"
                     /codon_start=1
                     /translation="MNNMSFAAPMGSRPCDLGLFCCCSSCFCLCCPRHRPVSRLAAVV
                     GGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLVFANQPDHSAPLGV
                     TRPSAPPLPHVVDLPQLGPRR"
     CDS             5147..7129
                     /product="ORF2"
                     /codon_start=1
                     /translation="MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGD
                     RVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAVASRRRP
                     TTAGAAPLTAVAPAHDTPPVPDVDSRAAILRRQYNLSTSPLTSSVATGTNLVLYAAPL
                     SPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTT
                     PTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLV
                     MLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRG
                     ADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAG
                     GQLFYSRPVVSAHGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQD
                     RPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTAPVYVSDSVTLVNVATGAQ
                     AVARSLDWTKVTLDGRPLSTIQQYPKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTAS
                     DQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTLDYPACAHTFD
                     DFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL"
BASE COUNT     1218 a   2308 c   1869 g   1799 t
ORIGIN      
        1 aggcagacca catatgtggt cgatgccatg gaggcccatc agtttattaa ggctcatggc
       61 atcactactg ctattgagca ggctgctcta gcggcggcca actctgccct ggcgaatgct
      121 gtggtagtta ggccttttct ctctcaccag cagattgaga tcctcattaa cctaatgcaa
      181 cctcgccagc ttgttttccg ccccgaggtt ttctggaatc atcccatcca gcgtgtcatc
      241 cataacgagc tggagcttta ctgccgcgcc cgctccggcc gttgtcttga aattggcgcc
      301 catccccgct caataaatga taatcctaat gtggtccacc gctgcttcct cctccctgtc
      361 gggcgtgatg ttcagcgctg gtatactgct cccactcgcg ggccggctgc taattgccgg
      421 cgttccgcgc tgcgcgggct tcccgctgtt gaccgcactt actgcctcga cgggttttct
      481 ggctgtaact ttcccgccga aactggcatc gccctctact cccttcatga tatgtcacca
      541 tctgatgtcg ccgaggccat gttccgccat ggtatgacgc ggctctatgc tgccctccat
      601 cttccgcctg aggtcttgct gcctcctggc acatatcgca ccgcatcgta tttgctgatt
      661 catgacggta ggcgcgttgt ggtgacgtat gagggtgata ctagtgctgg ttataaccac
      721 gacgtctcca acttgcgctc ctggattaga accaccaagg ttaccggaga ccatcccctc
      781 gttatcgagc gggttagggc cattggctgc cactttgttc tcttgctcac ggcagccccg
      841 gagccatcac ctatgcctta tgtcccttac ccccggtcta ccgaggtcta tgtccgatcg
      901 atcttcggcc cgggtggcac cccttcctta ttcccaacct catgctccac taagtcgacc
      961 ttccatgctg tccctgccca tatttgggac cgtcttatgc tgttcggggc caccttggat
     1021 gaccaagcct tttgctgctc ccgcttaatg acctaccttc gcggcattag ctacaaggtt
     1081 actgttggta cccttgtggc taatgaaggc tggaatgcct ctgaggacgc cctcacagct
     1141 gtcatcactg ccgcttacct taccatttgc caccagcggt atctccgcac ccaggctata
     1201 tccaagggga tgcgtcgtct ggaacgggag catgcccaga agtttataac acccctctac
     1261 agctggctct tcgagaagtc cggccgtgat tacatccctg gccgccagtt ggagttctac
     1321 gcccagtgca ggcgctggct ctccgccggc tttcatcttg atccacgggt gttggttttt
     1381 gacgagtcgg ccccctgccg ttgtaggacc gcgatccgta aggcgctctc aaagttttgc
     1441 tgcttcatga agtggcttgg tcaggagtgc acctgtttcc tccagcctgc agaaggcgtc
     1501 gtcggcgacc agggtcatga taatgaagcc tatgaggggt ccgatgttga ccctgctgag
     1561 tctgccatta gtgacatatc tgggtcctat gtcgtccctg gcactgccct ccagccgctc
     1621 taccaggccc tcgatctccc cgctgagatt gtggctcgcg cgggtcggct gaccgccaca
     1681 gtaaaggtct cccaggtcga tgggcggatc gactgcgaga cccttcttgg taataaaacc
     1741 tttcgcacgt cgttcgttga cggggcggtc ttagaggcca atggcccaga gcgctacaat
     1801 ctctccttcg atgccagtca gagcactatg gccgctggcc ctttcagtct cacctatgcc
     1861 gcctctgcag ctgggctgga ggtgcgctat gttgctgccg ggcttgacca tcgggcggtt
     1921 tttgcccccg gtgtttcacc ccggtcagcc cccggcgagg ttaccgcctt ctgctctgcc
     1981 ctatacaggt tcaaccgtga ggcccagcgc cattcgctga ccggtaactt atggttccat
     2041 cctgagggac tcattggcct cttcgccccg ttttcgcccg ggcatgtttg ggagtcggct
     2101 aatccattct gtggcgagag cacactttac acccgtactt ggtcggaggt tgatgccgtc
     2161 tctagtccag cccggcctga cttaggtctt atgtctgagc cttctatacc tagtagggcc
     2221 gccacgccta ccctggcggt ccttctaccc ccccctgcac cggaccctcc cccccctccc
     2281 tctgccccgg cgcttgatga gccggcttct ggcgctaccg ccggggcccc ggccataacc
     2341 caccagacgg cccggcaccg ccgcctgctc ttcacctacc cggatggctc taaggtattc
     2401 gccggctcgc tgttcgagtc cacatgcacg tggctcgtta acgcgtctaa tgttgaccac
     2461 cgccctggtg gcgggctctg ccatgcattt taccaaaggt accccgcctc ctttgatgct
     2521 gcctcttttg tgatgcgcga cggcgcggcc gcgtacacac taaccccccg gccaataatt
     2581 cacgctgtcg cccctgatta taggttggaa cataacccaa agaggcttga ggctgcttat
     2641 cgggaaactt gctcccgcct cggcaccgct gcatactcgc tcctcgggac cggcatatac
     2701 caggtgccga tcggccccag ttttgacgcc tgggagcgga accaccgccc cggggatgag
     2761 ttgtaccttc ctgagcttgc tgccagatgg tttgaggcca ataggccgac ccgcccgact
     2821 ctcactataa ctgaggatgt tgcacggaca gcgaatctgg ccatcgagct tgactctgcc
     2881 acagatgtcg gccgggcctg cgccggctgt cgggtcaccc ccggcgttgt tcagtaccag
     2941 tttactgcag gtgtgcctgg atccggcaag tcccgctcta tcacccaagc cgatgtggac
     3001 gttgtcgtgg tcccgacgcg tgagttgcgt aatgcctggc gccgtcgcgg ctttgctgct
     3061 tttaacccgc atactgccgc cagagtcacc caggggcgcc gggttgtcat tgatgaggct
     3121 ccatccctcc cccctcacct gctgctgctc cacatgcagc gggccgccac cgtccatctt
     3181 cttggcgacc cgaaccagat cccagccatc gactttgagc acgctgggct cgtacccgcc
     3241 atcaggcccg acctaggccc cacctcctgg tggcatgtta cccatcgctg cccagcggat
     3301 gtatgtgagc tcatccgtgg tgcatacccc atgatccaga ccactagccg ggttctccgt
     3361 tcgctgttct ggggtgagcc tgccgtcggg cagaaactag tgttcaccca ggcggccaag
     3421 gccgccaacc ccggctcagt gacggtccac gaggcgcagg gcgctaccta cacggagacc
     3481 actattattg ccacagcaga tgcccggggc cttattcagt cgtctcgggc tcatgccatt
     3541 gttgctctga cgcgccacac tgagaagttc gtcatcattg acgcaccagg cctgcttcgc
     3601 gaggtgggca tctccgatgc aatcgttaat aactttttcc tcgctggtgg cgaaattggt
     3661 caccagcgcc catcagttat tccccgtggc aaccctgacg ccaatgttga caccctggct
     3721 gccttcccgc cgtcttgcca gattagtgcc ttccatcagt tggctgagga gcttggccac
     3781 agacctgtcc ctgttgcagc tgttctacca ccctgccccg agctcgaaca gggccttctc
     3841 tacctgcccc aggggctcac cgcctgtgat agtgtcgtaa catttgaatt aacagacatt
     3901 gtgcactgcc gcatggccgc cccgaaccag cgcaaggccg tgctgtccac acttgtgggc
     3961 cgctacggcc gtcgcacaaa gctctataat gcttcccact ctgatgtccg cgactctctc
     4021 gcccgtttta tcccggccat tggccccgta caggttacaa cttgtgaact gtacgagcta
     4081 gtggaggcca tggtcgagaa gggccaggat ggctccgccg tccttgagct cgatctttgc
     4141 aaccgtgacg tgtccaggat caccttcttc cagaaagatt gtaacaagtt caccacaggt
     4201 gagaccatcg cccatggtaa agtgggccag ggcatctcgg cctggagcaa gaccttctgc
     4261 gccctctttg gcccttggtt tcgcgctatt gagaaggcta ttctggccct gctccctcag
     4321 ggtgtgtttt acggtgatgc ctttgatgac accgtcttct cggcggctgt ggccgcagca
     4381 aaggcatcca tggtgtttga gaatgacttt tctgagtttg actccaccca gaataacttt
     4441 tctctgggcc tagagtgtgc tattatggag gagtgtggga tgccgcagtg gctcatccgc
     4501 ttgtatcacc ttataaggtc ggcgtggatc ttgcaggccc cgaaggagtc tctgcgaggg
     4561 ttttggaaga aacactccgg tgagcccggc actcttctat ggaatactgt ctggaatatg
     4621 gccgttatta cccactgtta tgacttccgc gattttcagg tggctgcctt taaaggtgat
     4681 gattcgatag tgctttgcag tgagtatcgt cagagtccag gagctgctgt cctgatcgcc
     4741 ggctgtggct tgaagttgaa ggtggatttc cgcccgatcg gtttgtatgc aggtgttgtg
     4801 gtggcccccg gccttggcgc gctccctgat gttgtgcgct tcgccggccg gcttaccgag
     4861 aagaattggg gccctggccc tgagcgggcg gagcagctcc gcctcgctgt tagtgatttc
     4921 ctccgcaagc tcacgaatgt agctcagatg tgtgtggatg ttgtttcccg tgtttatggg
     4981 gtttcccctg ggcttgttca taacctgatt ggtatgctac aggctgttgc tgatggcaag
     5041 gcacatttca ctgagtcagt aaaaccggtg ctcgacttga caaattcaat cttgtgtcgg
     5101 gtggaatgaa taacatgtct tttgctgcgc ccatgggttc gcgaccatgc gacctcggcc
     5161 tattttgttg ctgctcctca tgtttttgcc tatgttgccc gcgccaccgc ccggtcagcc
     5221 gtctggccgc cgtcgtgggc ggcgcagcgg cggttccggc ggtggtttct ggggtgaccg
     5281 ggttgattct cagcccttcg caatccccta tattcatcca accaacccct tcgcccccga
     5341 tgtcaccgct gcggccgggg ctggacctcg tgttcgccaa ccagcccgac cactcggctc
     5401 cgcttggcgt gaccaggccc agcgccccgc cgttgcctca cgtcgtagac ctaccacagc
     5461 tggggccgcg ccgctaaccg cggtcgctcc agcccatgac accccgccag tgcctgatgt
     5521 cgactctcgc gccgccatct tgcgccggca gtataatcta tcaacatctc ccctcacttc
     5581 ttccgtggcc accggcacta acctggttct ttatgccgcc cctcttagtc cgctcttacc
     5641 tcttcaggac ggcaccaata cccatataat ggccacggaa gcttctaatt atgcccagta
     5701 ccgggttgtc cgtgccacaa tccgttaccg cccgctggtc cccaatgctg tcggcggtta
     5761 tgccatctcc atctcattct ggccacagac caccaccacc ccgacgtccg ttgatatgaa
     5821 ttcaataacc tcgacggatg ttcgtatttt agtccagccc ggcatagcct ctgagcttgt
     5881 gatcccaagt gagcgcctac actatcgtaa ccaaggctgg cgctccgtcg agacctctgg
     5941 ggtggctgag gaggaggcta cctctggtct tgttatgctt tgcatacatg gctcacccgt
     6001 aaattcctat actaacacac cctataccgg tgccctcggg ctgctggact ttgcccttga
     6061 gcttgagttt cgcaacctta cccccggtaa caccaatacg cgggtctccc gttattccag
     6121 cactgctcgc caccgccttc gtcgcggtgc ggacgggact gccgagctca ccaccacggc
     6181 cgctacccgc tttatgaagg acctctattt tactagtact aatggtgtcg gtgagatcgg
     6241 ccgcgggata gccctcaccc tgtttaacct tgctgacact ctgcttggcg gcctgccgac
     6301 agaattgatt tcgtcggctg gtggccagct gttctactcc cgtcccgtcg tctcggccca
     6361 tggcgagccg actgttaagt tgtatacatc tgtagagaat gctcagcagg ataagggtat
     6421 tgcaatcccg catgacattg acctcggaga atctcgtgtg gttattcagg attatgacaa
     6481 ccaacatgaa caagatcggc cgacgccttc tccagcccca tcgcgccctt tctctgtcct
     6541 tcgagctaat gatgtgcttt ggctctctct caccgctgcc gagtatgacc agtccactta
     6601 tggctcttcg actgccccag tttatgtttc tgactctgtg accttggtta atgttgcgac
     6661 cggcgcgcag gccgttgccc ggtcgctcga ttggaccaag gtcacacttg acggtcgccc
     6721 cctctccacc atccagcagt acccgaagac cttctttgtc ctgccgctcc gcggtaagct
     6781 ctctttctgg gaggcaggca caactaaagc cgggtaccct tataattata acaccactgc
     6841 tagcgaccaa ctgcttgtcg agaatgccgc cgggcaccgg gtcgctattt ccacttacac
     6901 cactagcctg ggtgctggtc ccgtctccat ctctgcggtt gctgttttag ccccccactc
     6961 tgcgctagca ttgcttgagg ataccttgga ctaccctgcc tgcgcccata cttttgatga
     7021 tttctgccca gagtgccgcc ctcttggcct ccagggctgc gctttccagt ctactgtcgc
     7081 tgagcttcag cgccttaaga tgaaggtggg taaaactcgg gagttatagt ttatctgctt
     7141 gtgcccccct tctttctgtt gcttatttct tatttctgcg ttccgcgctc cctg
//