From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human germline ENL mRNA, complete cds.
Date: 29 Dec 92 01:19:03 GMT
Distribution: bionet
Checksum: 31676 4

LOCUS       HUMENL       1680 bp ss-mRNA            PRI       07-DEC-1992
DEFINITION  Human germline ENL mRNA, complete cds.
ACCESSION   L04285
KEYWORDS    ENL; acute leukemia; chromosomal translocation; homologue;
            trithorax.
SOURCE      Homo sapiens cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Tkachuk,D.C., Kohler,S. and Cleary,M.L.
  TITLE     Involvement of a homolog of Drosophila trithorax by 11q23
            chromosomal translocations in acute leukemias
  JOURNAL   Cell 71, 691-700 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             1..1680
                     /standard_name="ENL"
                     /gene="ENL"
                     /note="translocated to HRX in t(11;19) leukemia"
                     /codon_start=1
                     /translation="MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDI
                     QHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTY
                     DLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPM
                     LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKEL
                     EREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPNPGPPPPP
                     PPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKS
                     STRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE
                     PSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADS
                     SLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMA
                     LRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT"
BASE COUNT      408 a    576 c    480 g    216 t
ORIGIN      
        1 atggacaatc agtgcaccgt ccaggtgagg ttagagctgg ggcatcgcgc ccaactgcgc
       61 aagaagccca ccacggaggg gttcactcac gactggatgg tgtttgtccg cggccccgag
      121 caatgtgaca tccagcactt cgtggagaag gtggtcttct ggctgcacga cagcttcccc
      181 aagcccagac gcgtgtgcaa ggagcccccc tacaaagtag aggagtcggg gtacgctggc
      241 ttcatcatgc ccatcgaggt gcacttcaaa aacaaggagg agccgaggaa ggtctgcttc
      301 acctacgacc tgttcctgaa cctggaaggc aacccgcccg tgaaccacct gcgctgcgag
      361 aagctcacct tcaacaaccc caccacggag ttccggtaca agctcctgcg ggccggcggg
      421 gtgatggtaa tgcccgaagg agcagacacg gtgtccaggc ccagtcccga ctaccccatg
      481 ttacccacaa ttccactctc tgccttctct gaccccaaga agaccaaacc atcccacggc
      541 tccaaggacg ccaacaagga gagcagcaag acctccaagc cacacaaggt gaccaaggag
      601 caccgggagc gcccccgcaa agactccgag agcaagagct cctccaagga gctggagcgt
      661 gagcaggcca aaagctccaa ggacacctcg cggaagctgg gcgagggccg gctgcccaag
      721 gaggagaagg cgccaccgcc caaggctgcc ttcaaggaac ccaagatggc cctgaaagag
      781 accaagctgg aaagcacgtc ccccaaccct gggcccccac ccccaccccc acccccaccc
      841 cgggcttcca gcaagcggcc ggccaccgcc gactcgccaa agcccagcgc caagaagcag
      901 aagaagagca gctcgaaggg gtcccggagt gctccaggca cctcgccccg cacctcctcc
      961 tcctcctcct tctcggacaa gaagccggcc aaggacaaga gcagcaccag aggggagaag
     1021 gtgaaggccg agagtgagcc ccgggaggcc aaaaaggccc tggaggtgga ggagtccaac
     1081 tcagaggacg aggcctcctt caagtccgag tctgcccagt caagcccgtc caactccagc
     1141 tccagctcag actccagctc agactcagac ttcgagccat cccagaacca cagccaagga
     1201 cccctgcgct ccatggtgga ggacctgcag tccgaggagt ccgacgagga cgactcttcg
     1261 tcaggcgagg aggctgccgg caagaccaac ccggggaggg actccaggtt gagcttcagc
     1321 gacagcgaga gtgacaacag cgccgactcc tccctgccca gccgtgagcc cccacccccc
     1381 cagaagccac ccccgcccaa cagcaaggtg tcaggccgga ggagccccga gtcctgcagc
     1441 aagcctgaga agatcctcaa gaagggcacc tacgacaagg cctacacgga tgagctggtg
     1501 gagctacacc ggaggctgat ggcgctgcgg gagcgcaacg tgctgcagca gattgtgaat
     1561 ctgatcgagg agactggcca cttcaatgtc accaacacca ccttcgactt cgacctcttc
     1621 tccctggacg agaccaccgt gcgcaaactg cagagctgcc tggaggccgt ggccacatga
//