From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Hirudo medicinalis transcription factor (Lox1) mRNA, complete cds.
Date: 28 Dec 92 21:43:01 GMT
Distribution: bionet
Checksum: 02693 6

LOCUS       HIRLOXI      2221 bp ss-mRNA            INV       02-DEC-1992
DEFINITION  Hirudo medicinalis transcription factor (Lox1) mRNA, complete cds.
ACCESSION   L07298
KEYWORDS    Lox1 protein; homeodomain protein; transcription factor.
SOURCE      Hirudo medicinalis hermaphrodite adult whole animal cDNA to mRNA.
  ORGANISM  Hirudo medicinalis
            Eukaryota; Animalia; Metazoa; Annelida; Hirudinoidea; Hirudinea;
            Arhynchobdellae; Hirudinidae.
REFERENCE   1  (bases 1 to 2221)
  AUTHORS   Aisemberg,G.O. and Macagno,E.R.
  TITLE     Lox1, a leech homeobox gene expressed during gangliogenesis in a
            segmentally repeated set of both transient and stable central
            neurons
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            1..1124
                     /number=1
                     /gene="Lox1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     exon            1125..2221
                     /number=2
                     /gene="Lox1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     3'UTR           1613..2221
                     /function="3'-untranslated trailer sequence"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     polyA_signal    2150..2155
                     /citation=[1]
                     /note="putative"
     polyA_site      2203..2208
                     /citation=[1]
                     /note="putative"
     CDS             350..1612
                     /function="transcription factor"
                     /standard_name="Lox1 homeodomain protein"
                     /gene="Lox1"
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
                     /partial
                     /note="The translation start will be located somewhere
                     else if adownstream splice acceptor site is used (the
                     sequence from 1to 869 was obtained from a genomic clone
                     that overlaps withthe cDNA)"
                     /product="Lox1 protein"
                     /codon_start=1
                     /translation="MSTASTQESTLKAILQDLKQFEENFPDMKSTTNSCALPPLHQLQ
                     SSSYLAHSFPQVEWNENVVHFDSCPVRHFPPPCDDNFHQEDAIGQNLNETFNHDNFTM
                     TLRQQHFHATPSNCEKTDPSSSSMLENKKKFLPLIFSQEQFKFNYSRQKEELIQGNEI
                     SSCDKECSNNEDEEEEDNEEGNLANQTFVGEKPVNLDCGDSAATTNSCLGSVELKDET
                     GNTKNFKEEKKFPSKRDSEKHVKNFFLIYPWMKRMHQNGQEKSSNGQQKNNSASATDN
                     KRLRTSYSRQQTLELEKEFHFNRYLTKRRRVEIAQMLKLSERQIKIWFQNRRMKWKKE
                     NSQENIAKMHFQRQYFLQQQLYFQRNESMTPHYAPIQQDLQPCNFFSHHHHQQQQQHF
                     YYDVDEIHPQYQQHMESQFHQDHYSQFPM"
BASE COUNT      746 a    457 c    393 g    625 t
ORIGIN      
        1 aagcttaaaa tacacttttt aatgtttaat aactgttatt ttgatttcac ttaattaatt
       61 acaaactcca tttatggtag acgtggtcca ttttaatgtc tgacgctcaa gcaggatgtt
      121 gatgagggcg gagttatgat cattgtttta ttcctattgg ttgattctca ttacaagcca
      181 tccgtaattg gtagattaac cgatcaatca cacgtctact ttaatattct tcattcgtaa
      241 ttaacatttg tcgcatattt gacggtaaaa tcgtatttta attaaatgaa tttgtttgga
      301 atttggagtt caaatttaat tcagataacg agtactttga aaaataagca tgtcaactgc
      361 atcaactcaa gaaagcaccc ttaaagccat ccttcaagac ctcaaacaat tcgaagagaa
      421 ttttccagac atgaaatcca caacaaactc ttgtgcgttg ccacctctcc accaattgca
      481 gtctagttca tacttggctc attcctttcc tcaagtggaa tggaatgaaa atgtcgttca
      541 cttcgacagc tgtccagttc gacattttcc acctccatgc gacgataact tccaccagga
      601 agacgcgatt ggtcagaatt taaatgaaac tttcaaccac gacaacttca caatgactct
      661 gagacaacaa catttccatg caactccatc aaactgcgag aaaacagacc cttcgtcgag
      721 cagcatgttg gaaaacaaga agaagtttct tccgttgata ttttctcagg agcagttcaa
      781 gttcaattat tcacgccaaa aagaagaact catccaagga aatgagattt cgagctgcga
      841 taaggagtgc tccaacaacg aggacgaaga ggaagaagac aacgaggaag gcaacttggc
      901 gaaccaaact tttgttggtg aaaaacctgt gaatcttgac tgcggagatt cagctgccac
      961 aacaaatagc tgcttgggga gtgtggagtt aaaagatgaa acaggaaaca cgaaaaactt
     1021 taaagaggaa aaaaagttcc ccagcaagag ggactctgag aaacacgtca agaatttttt
     1081 tcttatctac ccgtggatga aaaggatgca ccaaaatggg caagaaaagt cttcgaacgg
     1141 ccagcaaaag aacaattcgg cgagtgccac tgacaacaaa agactgagga cctcttactc
     1201 caggcaacaa actttggaac tggagaagga attccacttc aacaggtacc tcaccaaacg
     1261 taggagggta gaaattgccc agatgttgaa actatcagag aggcagatca agatctggtt
     1321 ccagaacagg cgaatgaaat ggaagaaaga aaacagtcag gagaacatcg caaagatgca
     1381 cttccagagg cagtactttc tccagcaaca actctacttc caaagaaatg aatccatgac
     1441 gccccattat gctcccatcc agcaagacct tcaaccgtgc aacttctttt cccatcacca
     1501 ccaccaacaa cagcagcaac acttttacta tgacgtcgac gaaatccatc cacaatacca
     1561 acagcacatg gagagtcagt tccatcaaga tcattattca cagtttccaa tgtgaccgaa
     1621 tcgcattcaa cctgacgata atggacctct ttatcagtaa atgtcttgta aacaagttga
     1681 tggaaattga taatctttgt aaacagttga ctcagtggca tttgtaaaca aatcatttcg
     1741 tgcctgcgtg cattagcgag atatgcctaa tggctcgtac gacgtggaga ccagcttatt
     1801 taattccatg tttccgtttc aatatttcaa aactaaaaac acgtttctgc catttcaagc
     1861 agacttttgc aaacaattct tttatttcat tattttgctc atcttctgtt gtggatttaa
     1921 gtattagtta ttggcaaata acattgaatt gttcgacaaa tcaacaacac aaacgaacgt
     1981 aacaatggaa ggttttaaca attaacttaa aatgctttta caattcattt cttttaagtt
     2041 ttgctttaaa tcgctgttaa ttcatgcgtg gcgttcaatt taatcatttc aatcagacaa
     2101 cactcttcgt gtaagttttg atagaaatgc gcatttagaa aattttgaaa ataaatattt
     2161 tttgaattat aattttcgtt gcaaagataa ttttcaattg caaataaatt atttcaaatc
     2221 c
//