From: kristoff@NET.BIO.NET (Dave Kristofferson)
Newsgroups: bionet.sci-resources
Subject: NIH Guide, vol. 21, no. 35, pt. 1, 2 October 1992
Date: 9 Oct 92 01:57:28 GMT
Distribution: bionet


NOTE: The NIH Guide may be split into more than one mail message to
avoid truncation during e-mail distribution.  The first message always
begins with the RFP/RFA summary sections followed by the appended
texts of the full RFP/RFAs.
----------------------------------------------------------------------

$$XID NIHGUIDE 19921002 V21N35 P1O2 ************************************
X-comment: RFAs described: HD-93-08, DK-93-01, HS-93-01, HL-93-02-P

NIH GUIDE - Vol. 21, No. 35 - October 2, 1992

$$INDEX BEGIN *******************************************************

                               NOTICES

$$INDEX N1 **********************************************************

AVAILABILITY OF RESOURCE FOR DIETARY INTAKE AND NUTRITION RESEARCH
National Heart, Lung, and Blood Institute
INDEX:  HEART, LUNG, BLOOD

$$INDEX N2 **********************************************************

HUMAN SUBJECT PROTECTIONS WORKSHOPS
National Institutes of Health
Food and Drug Administration
INDEX:  NATIONAL INSTITUTES OF HEALTH; FOOD AND DRUG ADMINISTRATION

               NOTICES OF AVAILABILITY (RFPs AND RFAs)

$$INDEX R1 **********************************************************

BREEDING AND EXPERIMENTAL FACILITY FOR WOODCHUCKS (MARMOTA MONAX) (RFP
NIH-NIAID-DMID-93-10)
National Institute of Allergy and Infectious Diseases
INDEX:  ALLERGY, INFECTIOUS DISEASES

$$INDEX R2 12/18/92 *************************************************

FAMILY AND CHILD WELLBEING RESEARCH NETWORK (RFA HD-93-08)
National Institute of Child Health and Human Development
INDEX:  CHILD HEALTH, HUMAN DEVELOPMENT

$$INDEX R3 01/14/93 *************************************************

DIABETES ENDOCRINOLOGY RESEARCH CENTERS (RFA DK-93-01)
National Institute of Diabetes and Digestive and Kidney Diseases
INDEX:  DIABETES, DIGESTIVE, KIDNEY DISEASES

$$INDEX R4 01/22/93 *************************************************

GRANTS FOR HEALTH SERVICES DISSERTATION RESEARCH (RFA HS-93-01)
Agency for Health Care Policy and Research
INDEX:  HEALTH CARE POLICY, RESEARCH

$$INDEX R5 02/16/93 *************************************************

IMPROVING HYPERTENSIVE CARE FOR INNER CITY MINORITIES (RFA HL-93-02-P)
National Heart, Lung, and Blood Institute
INDEX:  HEART, LUNG, BLOOD

                        ONGOING PROGRAM ANNOUNCEMENTS

$$INDEX P1 **********************************************************

CHEMORECEPTION AND NUTRITION (PA-93-001)
National Institute on Deafness and Other Communication Disorders
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Dental Research
National Institute on Aging
National Institute of Child Health and Human Development
INDEX:  DEAFNESS, OTHER COMMUNICATION DISORDERS; DIABETES, DIGESTIVE,
KIDNEY DISEASES; DENTAL RESEARCH; AGING; CHILD HEALTH, HUMAN
DEVELOPMENT

$$INDEX P2 **********************************************************

PREVENTION OF END STAGE LIVER DISEASES BY MOLECULAR DIAGNOSIS (PA-93-
002)
National Institute of Diabetes and Digestive and Kidney Diseases
INDEX:  DIABETES, DIGESTIVE, KIDNEY DISEASES

$$INDEX P3 **********************************************************

RESEARCH INFRASTRUCTURE SUPPORT PROGRAM (PA-93-003)
National Institute of Mental Health
INDEX:  MENTAL HEALTH

This publication is also available electronically to institutions via
BITNET or INTERNET.  Alternative access is through the NIH Grant Line
using a personal computer.  Contact Dr. John James at 301/496-7554 for
details, or send an E-mail message to ZNS@NIHCU.

$$INDEX END *********************************************************

                               NOTICES

$$N1 BEGIN **********************************************************

AVAILABILITY OF RESOURCE FOR DIETARY INTAKE AND NUTRITION RESEARCH

NIH GUIDE, Volume 21, Number 35, October 2, 1992

P.T.  34; K.W. 0710095, 0780000

National Heart, Lung, and Blood Institute

The Nutrition Coordinating Center (NCC) at the University of Minnesota
is a unique national resource available for dietary data collection and
nutrient calculation for epidemiological studies, clinical trials, and
other medical research studies.  The center provides standardized
procedures for collecting food intake data and calculating nutrient
intakes at the high level of specificity needed for investigations of
the relationship between diet and disease.

Investigators can use the services of the NCC in two ways.  They can
license use of the Minnesota Nutrition Data System (NDS).  NDS is
microcomputer-based software for interactive dietary data collection
and nutrient calculation.  NDS prompts the user to describe food intake
at the level of detail required for dietary research and calculates the
nutrient content of the intake.  Then NDS presents the data on the
screen, in printed reports, or in ASCII files that can be merged with
other study data using statistical analysis software.  The NDS database
allows the user to describe over 150,000 foods and 6,000 brand name
products.  The database contains values for up to 93 nutrients,
including soluble and insoluble fiber fractions, 23 individual fatty
acids, and 18 amino acids.  NDS can be used to guide 24-hour dietary
recall interviews or to process food intake records.  NDS can also be
used to collect and analyze diet histories and to calculate the
nutrient content of recipes or menus.  A customized version of NDS is
being used in the National Health and Nutrition Examination Survey
(NHANES III) to collect dietary data from more than 30,000 Americans.

Alternatively, investigators can send dietary intake records to NCC for
processing.  Data collection and processing procedures can be
customized to meet the needs of specific studies.  Investigators may
reanalyze data collected in the past to take advantage of improved
analytical data and new nutrients added to the database.  Over the past
18 years, NCC has processed more than 300,000 records.

NCC also provides a two-day training program for dietary interviewers.
For investigators who send dietary intake records to NCC for
processing, the training ensures the use of standardized data
collection procedures tailored to the research protocol.  Interviewers
are certified following satisfactory completion of the training program
and follow-up exercises.  For investigators using the NDS directly, the
training is designed to enhance use of the software to meet research
protocol requirements.  Over the past 18 years, NCC has trained and
certified more than 700 dietary interviewers.

NCC receives major support from the National Heart, Lung, and Blood
Institute, the National Cancer Institute, and the National Center for
Health Statistics.  NCC services and software are used by investigators
in academia, government, non-profit organizations, and industry.  Users
are required to pay a fee to cover part of the operational costs.

For information and fee schedules, contact Marilyn Buzzard, Ph.D.,
Director, Nutrition Coordinating Center, 2221 University Avenue, SE,
Suite 310, Minneapolis, MN 55414, telephone (612) 627-4869, FAX (612)
627-4191.

INQUIRIES

Abby Ershow, Sc.D.
Lipid Metabolism - Atherogenesis Branch
Division of Heart and Vascular Diseases
National Heart, Lung, and Blood Institute
Bethesda, MD  20892
Telephone:  (301) 496-1681
FAX:  (301) 496-9882

$$N1 END ************************************************************

$$N2 BEGIN **********************************************************

HUMAN SUBJECT PROTECTIONS WORKSHOPS

NIH GUIDE, Volume 21, Number 35, October 2, 1992

P.T. 42; K.W. 0783005

National Institutes of Health
Food and Drug Administration

The National Institutes of Health (NIH) and the Food and Drug
Administration (FDA) are continuing to sponsor a series of workshops on
responsibilities of researchers, Institutional Review Boards (IRBs),
and institutional officials for the protection of human subjects in
research. The workshops are open to everyone with an interest in
research involving human subjects.  The meetings should be of special
interest to those persons currently serving or about to begin serving
as a member of an IRB.  Issues discussed at these workshops are
relevant to all other Public Health Service agencies.  The current
schedule includes the following:

SOUTHWESTERN WORKSHOP

DATES:  November 16 & 17, 1992

LOCATION:
Wyndham Warwick
5701 Main Street
Houston, TX  77005
Telephone:  (713) 526-1991

SPONSORS:
University of Texas Health Science Center at Houston
Prairie View A & M University

REGISTRATION:
Ms. Paula Knudson
Executive Coordinator
Office of Research Support Committee
University of Texas Health Science Center at Houston
P.O. Box 20036
Houston, TX  77225
Telephone:  (713) 792-5048

TITLE:  Geriatric Research as an Ethical Mandate:  Politics, Policy,
and Problems

DESCRIPTION:  Expanded life expectancies and expanding technologies are
swelling the ranks of the frail and disabled elderly.  Minimal research
has been carried out to understand the problems this subject group and
their families encounter in finding solutions to their health and
social needs.  The conference will identify key problems that need to
be studied; isolate the risks and benefits associated with behavioral,
clinical, or evaluation research designed to enroll this group as
subjects; and pose solutions that will meet the needs of regulators,
scientists, and the elderly.

The program is designed to be of interest to physicians, nurses,
pharmacists, scientific investigators, other health care professionals,
clergy, lawyers, medical, nursing, social work students, psychologists
and IRB members and administrators.  Attention will be paid to Federal
regulations with special emphasis on the assessment of risks---medical,
legal, and psychosocial.  Opportunities will be available through
workshops, question periods, and informal discussions for participants
to exchange ideas and interests with faculty and OPRR and FDA
representatives.

SOUTHEASTERN WORKSHOP

DATES:  January 14 & 15, 1993

LOCATION:
Sheraton Sand Key Resort
1160 Gulf Boulevard
Clearwater Beach, FL  33515
Telephone:  (813) 595-1611

SPONSORS:
University of South Florida
Florida A & M University

REGISTRATION:
Ms. Eileen Highsmith
Executive Secretary
University of South Florida
4202 E. Fowler Avenue (MP.FAO-126)
Tampa, FL  33620-7900
Telephone:  (813) 974-2897

TITLE:  Barriers to Informed Consent:  Language, Age Factors, Trauma,
and Women/Minority Issues

DESCRIPTION:  Today's researchers face numerous barriers to obtaining
an informed consent.  Such issues as age, language, mental capacity,
and sobriety may affect the ability of subjects to give a truly
informed consent.  Many of these barriers oftentimes impact the pool of
subjects which an investigator is willing (or able) to use in a
research project.  In addition, recent legislation from the Congress
was designed to address the issue of inadequate numbers of women and
minorities in research projects.  This conference has been designed to
address three main areas in which barriers to informed consent may
exist:  mental competence, ethnic and gender issues, and research with
children and the elderly.

The conference program is designed to be of value to physicians,
nurses, pharmacists, scientific investigators, and other health care
professionals.  All IRB members, students in health care areas and
administrators will also benefit from the conference.  Attention will
be given to Federal regulations governing research on human subjects,
with special emphasis placed on the assessment of risks---medical,
legal, and psychosocial.  Ample opportunities will be provided to
exchange ideas and interests, through question and answer sessions and
informal discussions.

SOUTHWESTERN WORKSHOP

DATES:  February 12 & 13, 1993

LOCATION:
Sheraton Tempe Mission Palms Hotel
60 East 5th Street
Tempe, AZ  85281
Telephone:  (602) 894-1400

SPONSORS:
Arizona State University
Northern Arizona University

REGISTRATION:
Ms. Carol Jablonski
IRB Coordinator
Office of the Assistant Vice President for Research
Arizona State University
Tempe, AZ  85287-3403
Telephone:  (602) 965-6788

TITLE:  Contemporary Issues in Human Subject Research:  Challenges for
Today's IRBs

DESCRIPTION:  This program is designed to be a practical working
session to explore contemporary issues in human subjects protection
including regulations and assurances, categorization of research
protocols, uses of special populations, experimental design and
scientific merit, fetal tissue research, ethical/legal issues in human
subjects research, and conflict of interest.  As appropriate, topics
will be discussed from the perspective of the clinical researcher and
the behavioral/social science researcher.  Issues will be discussed in
a panel format with ample time for audience questions.  An outstanding
faculty has been assembled.

This program should be of interest to researchers in clinical medicine
and the behavioral and social sciences.  Institutional Review Board
members, university and hospital administrators, lawyers, ethicists,
health care practitioners, students, and other persons with interests
in human subject protection issues.

For further information regarding these workshop or future NIH/FDA
National Human Subject Protections Workshops, contact:

Ms. Darlene Marie Ross
Executive Assistant for Education
Division of Human Subject Protections
Office for Protection from Research Risks
National Institutes of Health
9000 Rockville Pike
Building 31, Room 5B59
Bethesda, MD  20892
Telephone:  (301) 496-8101

$$N2 END ************************************************************

               NOTICES OF AVAILABILITY (RFPs AND RFAs)

$$R1 BEGIN NIH-NIAID-DMID-93-10 *************************************

BREEDING AND EXPERIMENTAL FACILITY FOR WOODCHUCKS (MARMOTA MONAX)

NIH GUIDE, Volume 21, Number 35, October 2, 1992

RFP:  NIH-NIAID-DMID-93-10

P.T. 34; K.W. 1002002

National Institute of Allergy and Infectious Diseases

The Enteric Diseases Branch of the Division of Microbiology and
Infectious Diseases, National Institute of Allergy and Infectious
Diseases, has a requirement for the continued development and use of
sequelae such as chronic hepatitis and hepatoma.  There is a
requirement for colony born animals for planned experiments.  The
contractor will be responsible for the development and maintenance of
a colony of breeding Marmota monax capable of yielding 100 weaned pups
per year; for the performance of experimental protocols on woodchucks
with viral agents, vaccines, and therapeutic agents; and for the
maintenance of experimental animals.

Request for Proposals (RFP) NIH-NIAID-DMID-93-10 is now available.
Proposals will be due on November 13, 1992.  It is anticipated that one
cost-reimbursement, level-of-effort contract will be awarded for a
period of five years.

To receive a copy of this RFP, please supply this office with two
self-addressed mailing labels.  All inquiries must be in writing and
addressed to the office below:

Sara Southard
Contract Specialist
National Institute of Allergy and Infectious Diseases
Solar Building, Room 3C07
6003 Executive Boulevard
Bethesda, MD  20892

All responsible sources may submit a proposal that will be considered
by the government.  This advertisement does not commit the government
to award a contract.

$$R1 END ************************************************************

$$R2 BEGIN HD-93-08 FULL-TEXT ***************************************

FAMILY AND CHILD WELLBEING RESEARCH NETWORK

NIH GUIDE, Volume 21, Number 35, October 2, 1992

RFA AVAILABLE:  HD-93-08

P.T. 34, AA; K.W. 0730010, 0730005

National Institute of Child Health and Human Development

Application Receipt Date:  December 18, 1992

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The Demographic and Behavioral Sciences Branch of the Center for
Population Research at the National Institute of Child Health and Human
Development (NICHD) announces the availability of an RFA that invites
applications for cooperative agreements (U01) to develop a research
network to investigate the relationship of family factors to child
welfare.  The research network will conduct a systematic analysis of
existing data to determine what can be learned by means of secondary
data analysis about the relationship of family factors to child
welfare.

Each investigator in the network will be expected to have demonstrated
expertise and access to at least one data set relevant to the topic.
Also, applicants must demonstrate that they have both the substantive
and statistical expertise to function as part of an interdisciplinary
research network.  Each investigator will be given support to pursue
his or her individual research agenda, but a large part of the
available resources will be held in reserve to address cooperative
research questions agreed upon by the network.  Each investigator will
propose both an individual research plan and a cooperative research
plan in which they identify areas of research that they would be
willing to cooperate in implementing.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This RFA,
Family and Child Wellbeing Research Network, is related to the priority
areas of family planning, educational and community-based programs,
maternal and infant health, immunization and infectious diseases, and
clinical preventive services.  Potential applicants may obtain a copy
of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0) or
"Healthy People 2000" (Summary Report:  Stock No. 017-001-00473-1)
through the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and
eligible agencies of the Federal government.  Applications from
minority individuals and women are encouraged.

Institutions may submit applications on behalf of more than one
Principal Investigator (PI), but each PI must submit a separate
application.

MECHANISM OF SUPPORT

The funding mechanism to be used to support the research network will
be the cooperative agreement (U01).  Cooperative agreements are
assistance mechanisms but differ from research project grants in that
there will be substantial programmatic involvement of the NICHD Project
Coordinator above and beyond the levels required for traditional
program management of grants.  Specifically, the Project Coordinator
will assist the PI in the research network.  All parties agree to
accept the participatory and cooperative nature of the group process.

This RFA is intended as a one time solicitation.  The total project
period for the research network is five years and applications
submitted in response to the present RFA must not request support for
more than five years.  Should there be a sufficient continuing program
need, the NICHD may reissue this RFA.  The anticipated award date is
July 1, 1993.

FUNDS AVAILABLE

It is anticipated that up to seven awards will be made.  $1 million of
direct cost support has been set aside to support the network for the
first year of the award, and this amount will increase by an inflation
factor in subsequent years of the network.   Approximately one half of
the resources allocated for the network will be devoted to support
cooperative research.  Resources available for cooperative research
will be very small in the first year of the network, but will increase
progressively in the subsequent years of the network.  The percentage
of funding for cooperative research will increase according to the
following schedule: 20 percent in FY 93, 35 percent in FY 94, 50
percent in FY 95, 65 percent in FY 96 and 80 percent in FY 97.  The
level of support is dependent on the receipt of a sufficient number of
applications of high scientific merit.  Although this program will be
provided for in the financial plan of the NICHD, the award of grants
pursuant to this RFA is also contingent on the availability of funds
for this purpose.

RESEARCH OBJECTIVES

There are a large number of social problems that impinge on the
wellbeing of children.  Among them, poverty and the emergence of an
underclass population with a growing dependence on public transfer
programs are highly visible areas of concern.  Moreover, family factors
such as marital instability, out-of-wedlock childbearing and changes in
the demographic and economic structure of the family seem to be
inextricably related to these and other problems affecting child
wellbeing.  It is important to describe fully these interconnections
and to formulate and test models of the causes and consequences of
these relationships.  It is also important to elucidate the mechanisms
of action by which family factors effect child wellbeing so that
possible avenues of social intervention can be ascertained, and
existing interventions, such as child support enforcement or child care
subsidies, can be evaluated.

The American family has undergone considerable change in modern times.
These changes are associated with changes in the way children are
raised and with changes in familial support structures that sustain and
develop children into productive adults.  It is the intent of this RFA
to measure both family factors and child wellbeing very broadly to
develop as comprehensive a picture as possible about the relationship
between these considerations.  It is important to understand how family
factors and socio-economic conditions combine to nurture children and
help them develop into productive adults from both an individual and
societal perspective.  It is important to understand how the
intergenerational structure of the family marshals resources to care
for dependent children and how intergenerational family processes
relate to public intervention to sustain and develop children.

The research network will confine its activity to secondary data
analysis.  The network will be assembled to achieve the broadest
possible coverage in terms of research perspective, analytical
technique and sources of data.  The focus of the network is the United
States, but the use of foreign data may be justified if it provides an
important insight into the American condition.  Investigators must
demonstrate that they have a long term research agenda that is
addressing important questions relevant to the research goals of this
RFA. In addition they must describe the sources of data to which they
have access and plan to use in their research plan.  It is important to
describe the extent to which the investigator has experience using
these data.  It is also important to outline the analytic plan of
attack and to describe the statistical techniques that will be employed
in each phase of the research plan.  The investigator must propose a
plan of action necessary to accomplish their personal research agenda
in this area.  Applicants must also present a research plan for work
they suggest for collaborative undertaking.

SPECIAL REQUIREMENTS

The cooperative agreement assistance mechanism imposes special
requirements on both the applicants and the NICHD.  These requirements
are detailed clearly in the full RFA.

APPLICATION PROCEDURES

The grant application form PHS 398 (rev. 9/91) is to be used in
applying for this grant.  The PHS 398 is available from most business
offices or grants/contracts offices at most institutions and can also
be obtained from the Office of Grants Inquiries, Division of Research
Grants, National Institutes of Health, 5333 Westbard Avenue, Room 449,
Bethesda, MD 20892, telephone (301) 496-7441.  Applications must be
received at the Division of Research Grants by December 18, 1992.  If
an application is received after that date, it will be returned to the
applicant without review.

REVIEW CONSIDERATIONS

Those applications that are complete, responsive, and competitive will
be evaluated in accordance with the criteria stated in the RFA
announcement for scientific/technical merit by a special Review
Committee convened by the NICHD.  The second level of review will be
provided by the National Child Health and Human Development Advisory
Council.

AWARD CRITERIA

The anticipated date of award is July 1, 1993.  An attempt will be made
to balance the network so that it will have a multi-disciplinary
composition, a diversity of research issues, and broad coverage of
extant data sources.  Awards will be made on the basis of the
scientific merit of each research application and the need to create a
balanced network.

INQUIRIES

It is essential to obtain a full version of this RFA before writing an
application.  Inquiries concerning this RFA are encouraged.  The
opportunity to clarify any issues or questions from potential
applicants is welcome.

To obtain a full version of the RFA or make inquiries regarding
programmatic issues contact:

V. Jeffery Evans, Ph.D., J.D.
Demographic and Behavioral Sciences Branch
Center for Population Research
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 8B13
Bethesda, MD  20892
Telephone:  (301) 496-1174
FAX:  (301) 496-0962

Direct inquiries regarding fiscal matters to:

Ms. Melinda Nelson
Office of Grants and Contracts
National Institute of Child Health and Human Development
Executive Plaza North Building, Room 505
Bethesda, MD  20892
Telephone:  (301) 496-5481
FAX:  (301) 402-0915

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.864.  Awards are made under authorization of the Public Health
Service Act, Title IV, Part A (Public Law 78-410, as amended by Public
Law 99-158, 42 USC 241 and 285) and administered under PHS grants
policies and Federal Regulations, 42 CFR Part 52 and 45 CFR Part 74.
This program is not subject to the intergovernmental review
requirements of Executive Order 12372, or to Health Systems Agency
review.

$$R2 END ************************************************************

$$R3 BEGIN DK-93-01 FULL-TEXT ***************************************

DIABETES ENDOCRINOLOGY RESEARCH CENTERS

NIH GUIDE, Volume 21, Number 35, October 2, 1992

RFA AVAILABLE:  DK-93-01

P.T. 04; K.W. 0715075, 0785050, 0765020, 0710030

National Institute of Diabetes and Digestive and Kidney Diseases

Letter of Intent Receipt Date:  December 14, 1992
Application Receipt Date:  January 14, 1993

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) invites applications for funding of one Diabetes Endocrinology
Research Center (DERC) grant to be competitively awarded in Fiscal Year
1994.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This RFA,
Diabetes Endocrinology Research Centers, is related to the priority
area of diabetes mellitus.  Potential applicants may obtain a copy of
"Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0) or
"Healthy People 2000" (Summary Report:  Stock No. 017-001-00473-1)
through the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and
eligible agencies of the Federal government.  Minority individuals and
women are encouraged to submit as Principal Investigators.  Foreign
institutions are not eligible to apply.

MECHANISM OF SUPPORT

Support of this program will be through the National Institutes of
Health (NIH) grant-in-aid core center (P30) award.  Responsibility for
the planning, direction, and execution of the proposed project will be
solely that of the applicant.  In addition to the requirements stated
in the announcement, awards will be administered under PHS grants
policy as stated in the PHS Grants Policy Statement.  The anticipated
award date will be December 1, 1993.

FUNDS AVAILABLE

The NIDDK anticipates awarding one DERC Grant in Fiscal Year 1994 on a
competitive basis.  The receipt of one competing continuation
application is anticipated, which will be in competition with the other
applications received in response to this announcement.  The
anticipated award will be for five years and will be contingent upon
the availability of appropriated funds.  Requests for support must be
limited to no more than $750,000 indirect costs per year.  Any
application exceeding this amount will be returned to the applicant.

RESEARCH OBJECTIVES

The NIDDK-supported DERCs are part of an integrated program of
diabetes-related research support provided by the NIDDK.  These Centers
have provided a focus for increasing collaboration and cost
effectiveness among groups of successful investigators at institutions
with established comprehensive diabetes research bases.

The objectives of the DERCs are to bring together investigators from
relevant disciplines in a manner that will enhance and extend the
effectiveness of research related to diabetes and its complications.
Applicants should consult with NIDDK staff concerning plans for the
development of the Center.

STUDY POPULATIONS

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDIES

It is NIH policy that women and minorities must be included in clinical
study populations unless there is a good reason to exclude them.  The
study design must seek to identify any pertinent gender or minority
differences.

For projects involving clinical research, the NIH requires applicants
to give special attention to the inclusion of women and minorities in
study populations.  If women or minorities are not included in the
study populations for clinical studies, a specific justification for
this exclusion must be provided.  Applications without such
documentation will not be accepted for review.

LETTER OF INTENT

Prospective applicants are asked to submit a letter of intent by
December 14, 1992.  The letter of intent need only include a
descriptive title of the proposed research, the name, address, and
telephone number of the Principal Investigator, the identities of other
key personnel and participating institutions, and the number and title
of the RFA in response to which the application may be submitted.

Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains is helpful in planning for the review of applications.
It allows NIDDK staff to estimate the potential review workload and to
avoid possible conflict of interest in the review.

The letter of intent is to be sent to the Chief, Review Branch, NIDDK
at the address noted below.

APPLICATION PROCEDURES

Applications are to be submitted on the form PHS 398 (rev. 9/91),
available at most institutional business offices and from the Office of
Grants Inquiries, Division of Research Grants, National Institutes of
Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone
(301) 496-7441.  On item 2a of the face page of the application,
applicants must enter the RFA number and title.

Applicants are strongly encouraged to request a copy of "Guidelines for
Diabetes Endocrinology Research Centers."  These guidelines contain
important additional information about the format, content, and review
criteria.  Prospective applicants may obtain guidelines from and may
address inquiries to Dr. Garfield at the address listed under
INQUIRIES.

Applications must be received by January 14, 1993.  The original and
three copies of the application must be sent or delivered to:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892**

Two additional copies of the application must be sent under separate
cover to:

Review Branch
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 406
Bethesda, MD  20892

REVIEW CONSIDERATIONS

Applications for a DERC grant will be evaluated by the NIH grant peer
review process.  Applications will be reviewed initially by an ad hoc
review group convened by the NIDDK and subsequently by the National
Diabetes and Digestive and Kidney Diseases Advisory Council.

Schedule

Letter of Intent Receipt Date:   December 14, 1992
Application Receipt Date:        January 14, 1993
Initial Review Dates:            Jun/Jul 1993
Second Level Review Date:        Sep/Oct 1993
Anticipated Award Date:          December 1, 1993

INQUIRIES

Written and telephone inquiries concerning this RFA are encouraged.
Direct inquiries regarding programmatic issues and requests to:

Dr. Sanford A. Garfield
Diabetes Centers Program Director
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 626
Bethesda, MD  20892
Telephone:  (301) 496-7418
FAX:  (301) 480-038

Direct inquiries regarding fiscal matters to:

Ms. Linda Stecklein
Team Leader and Grants Management Specialist
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 649
Bethesda, MD  20892
Telephone:  (301) 496-7467

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.847.  Awards are made under authorization of the Public Health
Service Act, Title IV, Part A (Public Law 78-410, as amended by Public
Law 99-158, 42 USC 241 and 285) and administered under PHS grants
policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74.  This
program is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.

$$R3 END ************************************************************

$$R4 BEGIN HS-93-01 FULL-TEXT ***************************************

GRANTS FOR HEALTH SERVICES DISSERTATION RESEARCH

NIH GUIDE, Volume 21, Number 35, October 2, 1992

RFA AVAILABLE:  HS-93-01

P.T. 34; K.W. 0730050, 0710030

Agency for Health Care Policy and Research

Application Receipt Date:  January 22, 1993

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The Agency for Health Care Policy and Research (AHCPR) announces the
availability of an RFA for grants for health services dissertation
research.  The AHCPR conducts research that will enhance the quality,
appropriateness, and effectiveness of health care services, and access
to such services.  The provision of dissertation grant support is part
of the effort of the AHCPR to stimulate the development of innovative
and timely research on issues related to the delivery of health care
services.  Grant support is designed to aid the career development of
new health services researchers and to encourage individuals from a
variety of academic disciplines and programs to study complex issues
with respect to health care services.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  The AHCPR
urges applicants to submit grant applications with relevance to
specific objectives of this initiative.  Potential applicants may
obtain a copy of "Healthy People 2000" (Full Report:  Stock No.
017-001-00474-0  or Summary Report:  Stock No. 017-001-00473-1) through
the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

A student applying for a dissertation research grant must be enrolled
in an accredited doctoral degree program in the social, management,
medical, or health sciences.  The student also must be conducting or
intending to conduct dissertation research on issues related to the
delivery of health care services as described below.  The proposed
Principal Investigator (PI) must be a registered doctoral candidate in
resident or nonresident status.  All requirements for the doctoral
degree other than the dissertation must be completed by the time of the
award.  This information must be verified in a letter of certification
from the thesis chairperson and submitted with the grant application
(see APPLICATION PROCEDURES).

The applicant may be either the institution that will administer the
grant on behalf of the proposed PI or the proposed PI applying as an
individual.  Whenever feasible, the proposed PI is encouraged to have
the application administered through an institution.

A proposed PI for dissertation research grant support need not be a
U.S. citizen.  However, a PI who is not a U.S. citizen and does not
have a permanent resident visa must apply through an institution.

A PI who receives support for dissertation research under a grant from
the AHCPR may not at the same time receive support under a predoctoral
training grant or fellowship grant awarded by any other agency of the
U.S. Department of Health and Human Services.

MECHANISM OF SUPPORT

This RFA will use the AHCPR small grant (R03).  Responsibility for the
planning, direction, and execution of the proposed project will be
solely that of the proposed PI.  In addition to the requirements stated
in this RFA, awards will be administered under PHS grants policy as
described in the PHS Grants Policy Statement.  The budget of an
application for a dissertation research grant must not exceed $20,000
in total direct costs for the entire project period.  An application
that exceeds this amount will be returned to the applicant.
Investigators may request support only for the amount of time necessary
to complete the dissertation.  A dissertation research grant usually is
awarded for a period of 12 months or less but may be awarded for up to
17 months.

FUNDS AVAILABLE

The AHCPR expects to fund about 15 to 20 dissertation research projects
in 1993.  The number of awards will depend on the availability of
funds.

RESEARCH OBJECTIVES

Only applications that propose studies in the areas identified in
section 902 of the Public Health Service Act are eligible for support.
Section 902 authorizes research in the following areas:

o  Effectiveness, efficiency, and quality of health care services
o  Outcomes of health care services and procedures
o  Clinical practice, including primary care and practice-oriented
research
o  Health care technologies, facilities, and equipment
o  Health care costs, productivity, and market forces
o  Health promotion and disease prevention
o  Health statistics and epidemiology
o  Medical liability
o  AIDS/HIV infection
o  Rural health services
o  Health of low-income, minority, elderly, and other underserved
populations

Applicants are encouraged to discuss the suitability of their research
topics by letter or by phone with AHCPR staff members listed under
INQUIRIES.

SPECIAL INSTRUCTIONS TO APPLICANTS CONCERNING INCLUSION OF WOMEN AND
MINORITIES IN RESEARCH STUDY POPULATIONS

The AHCPR requires applicants for research grants to include minorities
and women in study populations.  If women or minorities are excluded or
inadequately represented in research, a clear and compelling rationale
should be provided.  All applications for research submitted to the
AHCPR are required to address this policy with respect to the inclusion
of women and minorities.  Applications without such documentation will
not be accepted for review.

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 9/91) is to be used
in applying for these grants, in accordance with the special
instructions described here and in the application kit.  Research grant
application materials, special instructions for dissertation grant
applications, and the RFA are available from:

AHCPR Publications Clearinghouse
P.O. Box 8549
Silver Spring, MD  20907
Telephone:  1-800-358-9295

Applications must be received by Friday, January 22, 1993, to Division
of Research Grants, National Institutes of Health, Westwood Building,
Room 240, Bethesda, MD  20892.  A letter from the faculty committee or
university official directly responsible for supervising the
development and progress of the dissertation research must be submitted
with the application.  The letter must (1) fully identify the members
of the committee and certify their approval of the dissertation
proposal, (2) certify that all requirements for the doctoral degree
except the dissertation are completed (or will be completed by the time
for the grant award), and (3) note that the university official or
faculty committee expects the doctoral candidate to proceed with the
approved project proposal with or without AHCPR support.

REVIEW CONSIDERATIONS

Dissertation research grant applications will be reviewed under AHCPR
review procedures by non-Federal experts, senior AHCPR staff members,
and other experts in the Federal government.  Reviewers will be
selected on the basis of their health services research accomplishments
and knowledge and their experience in research career development.
Because reviews are rigorous, considerable methodological detail is
important in the narrative of the application.  All elements of the
application will be considered in the review process.  Primary emphasis
will be given to the significance, scientific merit, and feasibility of
the project.

Applications may be subject to triage to determine their scientific
merit relative to other applications received in response to this RFA.
The AHCPR will withdraw from further consideration those applications
judged by triage to be noncompetitive for award and notify the PI and
institutional official.  Those applications judged to be competitive
will undergo further scientific merit review.  Review results and
funding decisions will be announced approximately five months after the
submission date.  Review criteria, award criteria, and continuation of
support are described below.

Review Criteria

Applications are reviewed to determine their suitability to review
criteria in four major areas:  problem significance, research design,
investigator's qualifications and support structure, and budgetary
appropriateness.  Detailed criteria for these areas, as they relate to
dissertation research, are provided in the RFA.

AWARD CRITERIA

Reviewers will provide recommendations with regard to the scientific
and technical merit of the application and whether it should receive
further consideration.  Funding decisions are based on the
recommendations of the reviewers, the relevance of the project to
program priorities, and the availability of appropriated funds.

INQUIRIES

Written and telephone inquiries concerning this RFA are encouraged.
Applicants are encouraged to discuss programmatic issues, such as the
suitability of their research topics, by letter or telephone with:

Julius Pellegrino, M.B.A., M.P.H.
Program Coordinator, Dissertation Grants
Center for General Health Services Extramural Research
Executive Office Center, Suite 502
2101 E. Jefferson Street
Rockville, MD  20852
Telephone:  (301) 227-8357

Direct inquiries regarding instructions for completing the application
to:

Galen B. (Sandy) Warren, D.D.S., M.P.H.
Office of Scientific Review
Agency for Health Care Policy and Research
Executive Office Center, Suite 602
2101 E. Jefferson Street
Rockville, MD  20852
Telephone:  (301) 227-8449

Direct inquiries regarding fiscal and administrative matters to:

Ralph Sloat
Chief, Grants Management Branch
Agency for Health Care Policy and Research
Executive Office Center, Suite 601
2101 E. Jefferson Street
Rockville, MD  20852
Telephone:  (301) 227-8447

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.226.  Awards are made under authority of title IX of the Public
Health Service Act, as amended (42 U.S.C. 299-299c-6), and administered
under PHS grants policies and in accordance with regulations of Title
42 of the Code of Federal Regulations, Part 67, Subpart A.  The
requirements of Executive Order 12372, Intergovernmental Review of
Federal Programs, are not applicable to AHCPR research grant programs.

$$R4 END ************************************************************

$$R5 BEGIN HL-93-02-P FULL-TEXT *************************************

IMPROVING HYPERTENSIVE CARE FOR INNER CITY MINORITIES

NIH GUIDE, Volume 21, Number 35, October 2, 1992

RFA AVAILABLE:  HL-93-02-P

P.T. 34; K.W. 0715115, 0414014, 0413001, 0403004, 0502017

National Heart, Lung, and Blood Institute

Letter of Intent Receipt Date:  November 30, 1992
Application Receipt Date:  February 16, 1993

THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The Division of Epidemiology and Clinical Applications (DECA) invites
applications for demonstration and education projects aimed at
improvements in hypertensive care among inner city minority
populations.  The awards will be for a funding period of four years.
The program will focus on community-based health education and/or other
approaches for enhancing compliance and improving blood pressure
control in urban minority populations.  The intervention models should
be widely applicable and economical.  While hypertension is the focus
of the program, a multiple risk factor approach may be used to assess
changes in other cardiovascular risk factors.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This RFA,
Improving Hypertensive Care for Inner City Minorities, is related to
the priority area of heart disease and stroke.  Potential applicants
may obtain a copy of "Healthy People 2000" (Full Report:  Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1) through
the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic, for-profit and non-profit
organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and
eligible agencies of the Federal government.  Foreign organizations are
not eligible to apply and domestic applications may not include
international components.  Applications from minority individuals,
particularly African Americans and Hispanics, and women are encouraged.

MECHANISM OF SUPPORT

The support mechanism for this RFA will be the National Institutes of
Health (NIH) demonstration and education (D&E) research grant (R18).
Responsibility for the planning, direction, and execution of the
proposed project will be solely that of the applicant.  The total
project period for applications submitted in response to the present
RFA may not exceed four years.  The anticipated award date is September
30, 1993.

FUNDS AVAILABLE

It is anticipated that three to five centers will be supported over the
four year period of this program.  An estimated total cost (direct and
indirect) of $2,500,000 will be available for the first year of funding
for the entire program, with an estimated four year total cost of
$10,600,000.  This level of support is dependent upon the receipt of a
sufficient number of applications of high scientific merit.  Although
this program is provided for in the financial plans of the National
Heart, Lung, and Blood Institute (NHLBI), awards pursuant to this RFA
are contingent upon the availability of funds for this purpose.

RESEARCH OBJECTIVES

The primary objective of this four-year demonstration and education
research program is to develop, and to evaluate for feasibility,
acceptability, and effectiveness, methods to maintain therapy and
control of hypertension, for both newly and previously diagnosed
individuals, in inner city, primarily minority populations.  The focus
will be on community-based health education and other approaches for
enhancing compliance and improving blood pressure control among inner
city minority populations.  The delivery of and adherence to the
interventions is the main objective, rather than clinical algorithms
used to treat hypertension.  While the improvement of hypertensive care
is the focus of this program, other cardiovascular disease risk factors
may be included in the interventions, and changes in these factors
should be assessed.  The role of non-pharmacologic approaches to
reducing blood pressure, including drug and alcohol avoidance, should
be addressed.

Primary outcome measures to assess the interventions may include:
percentages aware of hypertension, screened for hypertension, treated
for hypertension, responding to treatment, and controlled to normal
levels of blood pressure; clinic attendance; and compliance with
therapy.  Secondary outcomes include the assessment of:  effects on
other CVD risk factors, e.g., cigarette smoking, overweight, lipid
profile, and diabetes; health quality of life measures; and cost
effectiveness of the interventions.

The experimental design is not restricted by this RFA.  Applicants
should develop their own independent design, and provide justification
for the proposed design.  The designs should focus on an integrated
approach including various management factors that have previously been
shown to be effective.  Health education and other approaches for
enhancing compliance and improving blood pressure control should be
adequately described.  A randomized design, comparing special
interventions against usual care would be one appropriate study design
to test intervention models.  If justified by the nature of the
proposed intervention, i.e., delivery of an intervention to a social
group (e.g., neighborhood or employee group), other designs will be
considered responsive.

Annual meetings, to be held in Bethesda, MD, are planned for the
exchange of information among investigators.  Applicants must budget
the travel costs associated with these meetings in their applications.

STUDY POPULATIONS

Because of their excess burden of hypertension, African Americans
should comprise a large proportion of the study population.  Although
there is no compelling evidence of excess burden from hypertension
among Hispanics compared to the population at large, socioeconomic
factors for inner-city members of this group may result in less than
optimal hypertension detection and treatment.  Therefore, the inclusion
of Hispanics, which may be best accomplished by the inclusion of
Hispanics as the majority of the sample at one of the study sites, may
be proposed.  Investigators should also consider other minority groups,
as well as low socioeconomic whites, for inclusion.  The inclusion of
low socioeconomic-status (SES) whites may provide some means to
separate the effects of SES and ethnicity.  As the lowest hypertension
control rates are seen in young African Americans, investigators should
address the advantages and disadvantages of oversampling this younger
segment of the population.

SPECIAL INSTRUCTIONS TO FOR INCLUSION OF WOMEN AND MINORITIES IN
CLINICAL RESEARCH STUDIES

For projects involving clinical research, the NIH requires applicants
to give special attention to the inclusion of women and minorities in
study populations.  If women and minorities are not included in the
study populations for clinical studies, specific justification for this
exclusion must be provided.  Applications without such documentation
will not be accepted for review.

LETTER OF INTENT

Prospective applicants are asked to submit, by November 30, 1992, a
letter of intent that includes a descriptive title of the proposed
research, the name, address, and telephone number of the Principal
Investigator, the identities of other key personnel and participating
institutions, and the number and title of the RFA in response to which
the application may be submitted.

Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains is helpful in planning for the review of applications.
It allows NHLBI staff to estimate the potential workload and to avoid
conflict of interest in the review.

The letter of intent is to be sent to:

C. James Scheirer, Ph.D.
Review Branch, Division of Extramural Affairs
National Heart, Lung, and Blood Institute
Westwood Building, Room 548
Bethesda, MD  20892
Telephone:  (301) 496-7363
FAX:  (301) 402-1660

APPLICATION PROCEDURES

The research grant application form 398 (rev. 9/91) is to be used in
applying for this award.  These forms are available at most
institutional business offices; from the Office of Grants Inquiries,
Division of Research Grants, National Institutes of Health, 5333
Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301)
496-7441; and from the NHLBI Program Administrator named below.

Applications must be received by February 16, 1993.  If an application
is received after that date, it will be returned to the applicant.  The
Division of Research Grants (DRG) will not accept any application in
response to this announcement that is essentially the same as one
currently pending initial review, unless the applicant withdraws the
pending application.  The DRG will not accept any application that is
essentially the same as one already reviewed.  This does not preclude
the submission of substantial revisions of applications already
reviewed, but such applications must include an introduction addressing
the previous critique.

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed by NIH staff for
completeness and responsiveness.  Incomplete applications will be
returned to the applicant without further consideration.  If the
application is not responsive to the RFA, NHLBI staff will contact the
applicant to determine whether to return the application to the
applicant or submit it for review in competition with unsolicited
applications at the next review cycle.

Applications that are found to be responsive will be reviewed for
scientific and technical merit by an initial review group, convened by
the Division of Extramural Affairs, NHLBI solely to review these
applications. The initial review will include an evaluation to
determine scientific merit relative to other applications received in
response to this RFA.  The NIH will withdraw from further competition
those applications judged non-competitive for award and notify the
applicant Principal Investigator and institutional official.  Those
applications judged to be competitive will be further evaluated for
scientific/technical merit by the usual peer review procedures,
including, if deemed appropriate, a reverse site visit at the
applicant's expense.  Secondary review of applications will be
conducted by the National Heart, Lung, and Blood Advisory Council.

AWARD CRITERIA

Applications recommended by the National Heart, Lung, and Blood
Advisory Council will be considered for award based upon scientific and
technical merit, overall program balance, and the availability of
funds.  The anticipated date of award is September 30, 1993.

INQUIRIES

Written and telephone inquiries concerning this RFA are encouraged.
The opportunity to clarify any issues or questions from potential
applicants is welcome.

Direct inquiries regarding programmatic issues to:

P. Scott Allender, M.D.
Prevention and Demonstration Research Branch
Division of Epidemiology and Clinical Applications
National Heart, Lung, and Blood Institute
Federal Building, Room 604
7550 Wisconsin Avenue
Bethesda, MD  20892
Telephone:  (301) 496-2465

Direct inquiries regarding fiscal matters to:

William W. Darby
Section Chief, Grants Operations Branch
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
Westwood Building, Room 4A11
Bethesda, MD  20892
Telephone:  (301) 496-7536

AUTHORITY AND REGULATIONS

This project is described in the Catalog of Federal Domestic Assistance
No. 93.837.  Awards are made under authorization of the Public Health
Service Act, Title IV, Part A (Public Law 78-410, as amended by Public
Law 99-158, 42 USC 241 and 285) and administered under PHS grants
policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74.  This
project is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.

$$R5 END ************************************************************

                     ONGOING PROGRAM ANNOUNCEMENTS

$$P1 BEGIN PA-93-001 ************************************************

CHEMORECEPTION AND NUTRITION

NIH GUIDE, Volume 21, Number 35, October 2, 1992

PA NUMBER:   PA-93-001

P.T. 34; K.W. 0710095, 1002004, 0705070

National Institute on Deafness and Other Communication Disorders
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Dental Research
National Institute on Aging
National Institute of Child Health and Human Development

PURPOSE

The purpose of this Program Announcement (PA) is to foster basic and
clinical research on the interactions between chemoreception and
nutrition.  This research may involve the effects of nutritional
variables on taste, smell, and somatosensory chemoreception, or this
research may involve the effects of chemosensory variables on nutrition
and diet.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Chemoreception and Nutrition, is related to the priority area of
nutrition.  Potential applicants may obtain a copy of "Healthy People
2000" (Full Report:  Stock No. 017-001-11474-0) or "Healthy People
2000" (Summary Report:  Stock No. 017-001-11473-1) through the
Superintendent of Documents, Government Printing Office, Washington, DC
20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic and foreign, for-profit and
non-profit organizations, public and private, such as universities,
colleges, hospitals, laboratories, units of State and local
governments, and eligible agencies of the Federal government.
Applications from minority individuals and women are encouraged.
Foreign institutions are not eligible for the First Independent
Research Support and Transition (FIRST) Award (R29).

MECHANISM OF SUPPORT

The mechanisms available for the support of this program are research
project grants (R01) and the FIRST Award (R29).

Applicants from institutions that have a General Clinical Research
Center (GCRC) funded by the NIH National Center for Research Resources
(NCRR) may wish to identify the GCRC as a resource for conducting the
proposed research.  In such a case, a letter of agreement from either
the GCRC program director or Principal Investigator must be included
with the application.

RESEARCH OBJECTIVES

The support of nutrition research at the National Institutes of Health
(NIH) includes studies designed to assess the consequences of food or
nutrient intake and utilization in the intact organism, including
humans, and the metabolic and behavioral mechanisms involved.  These
studies encompass investigation of nutrient variables at the cellular
or subcellular level.  These studies also include investigations of
genetic/ environmental interactions in which a nutrient is a variable
and dietary practices are expected to produce changes in health status,
including the maintenance of health and the treatment of disease in
humans.  Current research in nutrition at the NIH is periodically
reported in the Nutrition Coordinating Committee's publication entitled
"Nutrition Research at the NIH," which includes examples of
nutrition-related chemosensory research supported by the NIH.
Potential applicants may obtain a copy of "Nutrition Research at the
NIH" (NIH Publication No. 91-2611) through the Division of Research
Coordination, Building 31, Room 4B63, Bethesda, MD 20892 (telephone
301-496-4982).

The goal of this PA is to foster basic and clinical research that will
lead to a better understanding of the interactions between
chemoreception and nutrition and better preventive interventions for
chemosensory and nutritional disorders.  This research may involve the
effects of nutritional variables on chemoreception, including taste,
smell, and somatosensory responses related to oral and nasal
chemoreception; this research may also be focused on the effects of
chemosensory variables on nutrition and diet.  A broad range of studies
covering the molecular to the behavioral levels of research is
encouraged.  Interactions among investigators in various biomedical and
behavioral fields and disciplines are encouraged, including nutrition,
psychophysics, biochemistry, and molecular biology.

Research topics might include those below.  Investigators are
encouraged to consider other topics relevant to this program.

o  Nutritional influences, including excessive nutrient intake, on the
molecular structure and function of chemosensory epithelia and on
secretory transport and other perireceptor events related to
chemoreception, including mucosal defense mechanisms.

o  Alteration of chemosensory receptor membrane events, including the
modification of sweet, bitter, sour, and salt taste sensation, by
influencing receptor binding or second messenger activation.

o  Nutritional influences on the regeneration cycle of olfactory
receptor neurons and taste bud cells under normal physiological
conditions and after injury to the chemosensory systems.

o  Effects of dietary alterations in early life on the structure and
function of chemosensory systems, including trigeminal chemoreception;
effects of dietary alterations in early life on the development of
sweet, bitter, sour, and salty taste and amiloride-sensitive sodium
channels.

o  Mother-infant relationships involving odors and nutrition.

o  Relation of smell, taste, and somatosensory aspects of flavor
perception to the amount of food consumed and the types of foods
selected and rejected.

o  Genetic studies involving food preferences and individual
differences in chemosensory abilities, for example, the ability to
taste phenylthiourea and other bitter substances and to smell
androstenone; studies of patients with Kallmann's disease or familial
dysautonomia.

o  Associations between chemosensory disorders and altered food intake
in age-related conditions and various chronic disease states, including
oral and dental diseases (e.g., xerostomia, dental caries, and
periodontal disease), obesity, diabetes, inborn errors of metabolism,
and digestive, hepatic, and kidney diseases.

o  Effects of artificial sweeteners and salt substitutes on nutrition
and chemoreception.

o  Nutritional and chemosensory status in special subpopulations,
including minorities, nursing mothers, and postmenopausal women with
burning mouth symptoms; individuals with pseudohypoparathyroidism
associated with G protein deficiency and hyposmia; those receiving
hormonal therapy.

o  Iatrogenic alterations of nutritional and chemosensory status
resulting from interventions, such as oral and dental prosthesis,
hemodialysis, irradiation, and chemotherapy.

o  Impact of the affective dimensions of chemoreception in health and
disease on food choices and utilization; impact of depressive and
eating disorders on chemosensory affect and sensitivity; impact of
dysosmia and dysgeusia on food choices and intake.

o  Role of chemoreception in digestion and metabolism of nutrients.

o  Development of chemosensory test stimuli that mimic chemosensory
properties of food and permit stimulus control.

SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH
POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDY POPULATIONS.

NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical
research grants and cooperative agreements are required to include
minorities and women in study populations so that research findings can
be of benefit to all persons at risk of the disease, disorder or
condition under study; special emphasis must be placed on the need for
inclusion of minorities and women in studies of diseases, disorders and
conditions which disproportionately affect them.  This policy is
intended to apply to males and females of all ages.  If women or
minorities are excluded or inadequately represented in clinical
research, particularly in proposed population-based studies, a clear
compelling rationale must be provided.

The composition of the proposed study population must be described in