From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rabbit cytochrome P-450 and flanks; clone pP-450PBc2.
Date: 28 Jul 92 10:07:48 GMT
Distribution: bionet
Checksum: 01211     5

LOCUS       RABCY450A    1838 bp ss-mRNA            MAM       28-JUL-1992
DEFINITION  Rabbit cytochrome P-450 and flanks; clone pP-450PBc2.
ACCESSION   K01521
KEYWORDS    cytochrome; cytochrome P-450;
            phenobarbital-induced cytochrome P-450.
SOURCE      rabbit (48 hour phenobarbital-exposed New Zealand adult male); cDNA
            to liver mRNA, clone pP-450PBc2.
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Lagomorpha; Leporidae.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Leighton,J.K. and DeBrunner-Vossbrinck,B.A.
  TITLE     Isolation and sequence analysis of three cloned cDNAs for rabbit
            liver proteins that are related to rabbit cytochrome P-450 (form
            2), the major phenobarbital-inducible form
  JOURNAL   Biochemistry 23, 204-210 (1984)
  STANDARD  simple staff_entry
COMMENT     The sequences of 3 different rabbit cytochrome P-450 cDNAs were
            compared with each other and with a rat cytochrome P-450 gene [1].
            Rabbit and rat showed about 55-60% homology.
FEATURES             Location/Qualifiers
     CDS             <1..1442
                     /note="cytochrome P-450"
                     /codon_start=3
                     /translation="SCLLLLSLWKQSHGGGKLPPGPTPFPILGNVLQLDFKDLSKSLT
                     NLSKVYGPVFTVYLGMKPTVVVHGYEAVKEALVDLGHELSGRSRFLVTAKLNKGFGVI
                     FSNGKRWTETRRFSLMTLRNFGMGKRSIEERVQEEAHCLVEELRKTNASPCDPTFILG
                     AAPCNVICSVIFQNRFDYTDQDFLSLMGKFNENFKILNSPWVQFCNCFPILFDYFPGS
                     HRKAVKNIFYVKNYITEQIKEHQKSLDINNPRDFIDCFLIKMEQEKCNQQSEFTIENL
                     LTTVSDVFMAGTETTSTTLRYGLLLLMKHPEVIAKVQEEIERVIGRHRSPCMQDRSRM
                     PYTDATVHEIQRYINLIPNNVPHTTICNLKFRNYLIPKGTDVLTSLSSVLHDDKEFPN
                     PDRFDPGHFLDASGNFRKSDYFMPFSTGKRVCVGEALARMELFLFLTAILQNFTPKPL
                     VNPNNVDENLFSSGIVRVPPLYRVSFIPV"
BASE COUNT      485 a    445 c    407 g    501 t
ORIGIN      51 bp upstream of HindIII site.
        1 tctcctgttt gcttctcctt tcactctgga aacagagcca tgggggaggg aagcttcctc
       61 ctggccccac tccttttcca attcttggaa acgtcctgca gttagatttt aaggacttaa
      121 gcaaatcttt aaccaatctg tcaaaagtct atgggcccgt gttcactgtg tatctgggca
      181 tgaagcccac tgtggtggtg catgggtatg aagcagtgaa ggaggcccta gtcgatcttg
      241 gacacgagct ttctggaaga agccgtttcc tagtgactgc aaaacttaat aaaggatttg
      301 gagtcatttt cagcaatgga aagagatgga cggagacccg gcgcttctca ctcatgaccc
      361 tgcggaattt cggaatgggg aagaggagca ttgaggaacg agttcaagaa gaagcccact
      421 gcctggtgga ggagctgaga aaaaccaatg cctcaccctg tgatcccacc tttatcctgg
      481 gtgctgctcc ctgcaatgtg atctgctccg tgattttcca gaaccgtttt gattacacgg
      541 accaggattt tcttagtttg atgggaaagt tcaatgaaaa cttcaagatt ctgaattccc
      601 cctgggtaca gttctgcaat tgttttccta ttctcttcga ttatttccct gggagtcata
      661 ggaaagcagt taaaaatatt ttttatgtga agaattatat tacagagcaa ataaaggaac
      721 accaaaaatc cctggacatt aacaatcctc gggacttcat tgattgtttc ctgatcaaaa
      781 tggaacagga aaagtgtaat caacagtctg aatttactat tgaaaactta ctgaccacag
      841 tgagtgatgt gtttatggct ggaacagaga caacaagcac caccctgagg tatggacttc
      901 tactcctgat gaagcaccca gaagtcatag ctaaagtgca ggaggagatc gagcgtgtga
      961 ttggccgaca ccggagcccc tgcatgcagg acaggagccg catgccctac acggatgcca
     1021 cggtgcacga gatccagaga tacattaacc tcatccccaa caatgtgccc catacaacaa
     1081 tctgtaacct taagttcaga aactatctca tccccaaggg cacagatgta ctaacatcac
     1141 tgtcttctgt actgcatgac gacaaagagt tccccaaccc agacaggttt gaccctggcc
     1201 acttcttgga tgccagcggc aactttagga aaagtgacta cttcatgcct ttctcaacag
     1261 gaaaacgagt gtgtgtggga gaggccctgg cccgcatgga gctgtttctg ttcctgactg
     1321 ccattttaca gaactttacc ccgaaacctc tggtcaaccc aaacaatgtt gatgaaaatc
     1381 tattctccag tggaattgtc cgtgtgccac ccttgtaccg ggtcagcttc attcctgtct
     1441 gaggaaggtc aggtcacggg atgccatgct tacatctgca attccccttc ctccaggaca
     1501 ctcgccaact gtttccccct gtcatggggg cctgctctga cctggcctct gacatttcct
     1561 cattgcgcaa gatccattct ccattcggtg ggagtcacct gggtcccttc acaaatgtat
     1621 gtttgctatc accacactta atactcttgg cctgaccacc acatgggctt atacttgtat
     1681 aatactatgt catatgctgt cactgtaaat ttgggcaaga tgattgacat tggacagttt
     1741 ggatccgtat gtcctctgca tgctctaaat agaagcatta ttaattgctg aaatcagttc
     1801 tcaagttttc ttctttgtac ataatttgag taaaaatt
//