From: bhasker@nssdca.gsfc.nasa.gov (Bharat Bhasker)
Subject: Ph.D. Organic Chemistry, 10+ Yrs Pharmaceutical,Radio Chem and Research Exp.
News-Software: VAX/VMS VNEWS 1.41    
Organization: NASA - Goddard Space Flight Center
Date: Thu, 17 Dec 1992 17:11:00 GMT

I am posting this for a friend. Please direct all the inquiries to the
phone number listed in the resume.


                              HEMANT MISRA, Ph. D.

                                9131 Tymat Court
                                Laurel, MD 20723
                             (301) 317-7948 (Home)
                             (301) 419-2400 (Work)

Career Objective:

A challenging  position in  the  field of  Pharmaceuticals,  Organic/Medicinal
chemistry,  Nucleic   acids/Antisense  oligonucleotides,   Proteins/Bio-organic
chemistry, drug  delivery/bio-conjugation  or  Radio chemistry  to  utilize  my
skills and expertise.

Experience Summary:

Over 11 years  of experience in  organic/medicinal chemistry, modern  synthetic
strategies  including  chiral   methodology,  analytical,  chromatography   and
spectroscopic techniques. Ten  years in pharmaceuticals,  six years in  nucleic
acids and five years in  proteins, monoclonal antibodies, bio-conjugations  and
other bio molecules  as diagnostic agents  for their therapeutic  applications.
Strong leadership and  technical support in  multidisciplinary joint  projects.
Published 26 peer  reviewed papers  and presented 18  technical reports.  Also,
have knowledge of basic computer, strong leadership and project management.

Professional Experience:

Program Manager (Aug. 1991 - Present)
ANDRULIS Pharmaceutical Corporation, Beltsville, MD 20705

Designed and  implemented  research programs  in  the areas  of  organometallic
anti-tumor drugs,  rationale  drug  design,  bio  conjugation,  polymeric  drug
delivery  system.  Developed  new  and  improved  existing  methodologies   for
synthesis of  activated  biocompatible  polymers  and  their  conjugation  with
therapeutic   drugs.    Developed   effective    analytical   techniques    for
characterization of polymer-drug conjugates.  Initiated and supervised  several
collaborative projects with other major pharmaceutical companies. Prepared  and
managed project  performance plans,  schedule, budgets  and staffing.  Prepared
technical, management,  cost proposals  and  developed approaches  to  business
opportunities.  Provide  technical  supervision  and  advices  to  a  staff  of
scientists. Prepared and submit progress and final report.

Instructor (Oct. 1989 - Aug. 1991)
Univ. of Massachusetts Medical School, Dept. of Pharmacology

Synthesis and mechanistic study of specific nucleotide inhibitors for mammalian
DNA polymerases and nucleotide binding proteins to develop new chemotherapeutic
agents; designed  and  prepared  an  oligodeoxy  nucleotide  for  chemical  and
enzymatic incorporation study; synthesized novel nucleosides and nucleotides as
anti-viral  and   anti-tumor   agents;   prepared   novel   corbohydrates   for
regiospecific and  regioselective  synthesis  of  anti-AIDS  drugs.  Supervised
ongoing projects, post-docs and technicians.

Sr. Research Scientist (Nov. 1986 - Oct. 1989)
Univ. of Massachusetts Medical School, Dept. of Nuclear Medicine

Worked on a  research project with  responsibility for the  development of  new
radio pharmaceuticals as diagnostic agents for their therapeutic application in
cancer study. Applicant developed  novel organic bifunctional chelating  agents
for radiolabeling of monoclonal antibodies and proteins. Produced and  purified
proteins after chemical modification and coupled with biocytin and streptavidin
for abcess imaging study. Modern chromatographic (FPLC, HPLC, LC, SDS-PAGE) and
spectroscopic (NMR, IR, UV, MS, GC-MS), state of the art technique were used at
various stages  for  the preparation  of  these bio-molecules.  Supervised  and
managed  synthetic   organic   chemistry  lab.   Directed   radiopharmaceutical
preparations for different patient studies and determined pharmacokinetics in a
clinical study for a radiolabeled ACE antigen antibody (multidisciplinary joint
research  project  with  other  major  pharmaceutical  companies  like  Abbott,
Centocor, Cytogen, etc.).

Research Associate (June 1982 - Nov. 1986)
Univ. of Alberta, Edmonton, Canada, Faculty of Pharmacy  and Pharm. Sciences

Responsible for  synthesis of  heterocyclic  organic and  other  pharmaceutical
compounds for  their pharmacological  evaluation. Major  goal was  achieved  by
developing a  number  of  novel  radiolabeled  and  unlabeled  nucleosides  and
nucleotides as  diagnostic agents  for  oncology and  virology. Some  of  these
agents demonstrated significant antitumor and antiviral activities and clinical
study is  in progress  against  HSV I,  HSV II,  EBV  and HCM  virus.  Advanced
synthetic    methodologies    including    multistep    synthetic    sequences,
chromatographic and spectral interpretation were used to develop these agents.
This research program was funded  for four years. Supervised graduate  students
and lab technicians.

Visiting Research Scientist (Jan. 1981 - June 1982)
Univ. of Tokushima, Japan, Faculty of Pharmacy  and Pharm. Sciences

Designed and developed  a research  program in synthetic  organic chemistry.  A
wide variety  of  pharmaceutical compounds  were  synthesized and  studied  for
antitumor and other biological  properties. Spectroscopic techniques were  used
for structural determination and to follow reaction mechanism for the synthesis
of  these pharmaceutical compounds.  A novel synthetic method was developed for
the preparation of these compounds.

Postdoctoral Research Fellow (May 1979 - Dec. 1981)
Lucknow University, India, Dept. of Chemistry

Developed 4(3H)-quinazolone derivatives by modern synthetic methods and studied
their antimicrobial and anti-acetylcholinesterase activities.

Education:

Ph. D., (1980), Organic/Medicinal chemistry, Lucknow University, India

M. S., (1975), Organic chemistry, Lucknow University, India

Professional Affiliations:

American Chemical Society, Washington D.C., 1986- present
Society of Nuclear Medicine, New York, 1986 - 1989

Publications:

Published  26 scientific research papers and 18 reports. Many other papers  are
in preparation. A complete list of publications is available upon request.

References:

References furnished upon request

Personal:

Married since 1980; 3 children, excellent health; Permanent Resident of  United
States.


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