From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human c-myc-P64 mRNA, initiating from promoter P0, (HLmyc3.1)
Date: 5 Nov 92 23:11:01 GMT
Distribution: bionet
Checksum: 08231 6

LOCUS       HUMMYCPOB    2041 bp ss-mRNA            PRI       20-MAY-1987
DEFINITION  Human c-myc-P64 mRNA, initiating from promoter P0, (HLmyc3.1)
            partial cds.
ACCESSION   M13930
KEYWORDS    myc-P64 protein.
SOURCE      Human promyelocytic leukemia cell line HL60, cDNA to mRNA, clone
            HLmyc3.1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2041)
  AUTHORS   Bentley,D.L. and Groudine,M.
  TITLE     Novel promoter upstream of the human c-myc gene and regulation of
            c-myc expression in B-cell lymphomas
  JOURNAL   Mol. Cell. Biol. 6, 3481-3489 (1986)
  STANDARD  full automatic
COMMENT     Draft entry and printed copy of sequence [1] kindly provided by
            D.L.Bentley, 08-DEC-1986.
               There are four alternate transcription initiation sites at the
            P0 promoter.  Two are annotated in the FEATURES table.  THe other
            two are located 3-13 bp upsteam of position 1 (this entry).  The
            c-myc-P64 transcript is usually initiated at promoters P1 or P2 (
            also annotated in FEATURES table).  The polyadenylation site in
            clone HLmyc3.1 is located 944 bp downstream of position 2041.  [1]
            has also sequenced another mRNA from clone HLmyc2.5 that can be
            found under accession number M13929.
FEATURES             Location/Qualifiers
     mRNA            36..>2041
                     /note="P0 mRNA (alt.)"
     mRNA            55..>2041
                     /note="P0 mRNA (alt.)"
     mRNA            639..>2041
                     /note="P1 mRNA"
     mRNA            798..>2041
                     /note="P2 mRNA"
     CDS             40..384
                     /note="ORF 114"
                     /codon_start=1
                     /translation="MRCWVILIILGIVFLLMPLSFLPIYTNIPRSERAPINTLLSSTL
                     PGTLDQSAALSPALARRPAAWYARGVAVGAQCVLGVEGSCSACDDLYSQDKDAVCQTV
                     LLRRSSRERERV"
     CDS             612..1178
                     /note="ORF 118"
                     /codon_start=1
                     /translation="MRGSGRLRTPELCCSRPPPPGPGRPWLPSCLEKGRASQRLGGKK
                     NGGRDRAEYKSRFSGLYLTRCSNSSERQRERAGGRLGWKSRASRAALRASWEGRSGAN
                     RGLRLWPSPPADPPASGPQPLPHPRNFAHSSGRALCTGTYNTRARTRLSRRGEAILPI
                     WGHFPAAARTRFSERLSLQLLRRWIFFG"
     CDS             1205..1978
                     /product="truncated c-myc-P64 protein"
                     /codon_start=1
                     /translation="MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPA
                     PSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMV
                     TELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSG
                     SPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSP
                     SSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSGGTRR"
BASE COUNT      402 a    668 c    578 g    393 t
ORIGIN      65 bp upstream of SfaNI site.
        1 ggagtttatt cataacgcgc tctccaagta tacgtggcaa tgcgttgctg ggttatttta
       61 atcattctag gcatcgtttt cctccttatg cctctatcat tcctccctat ctacactaac
      121 atcccacgct ctgaacgcgc gcccattaat acccttcttt cctccactct ccctgggact
      181 cttgatcaaa gcgcggccct ttccccagcc ttagcgaggc gccctgcagc ctggtacgcg
      241 cgtggcgtgg cggtgggcgc gcagtgcgtt ctcggtgtgg agggcagctg ttccgcctgc
      301 gatgatttat actcacagga caaggatgcg gtttgtcaaa cagtactgct acggaggagc
      361 agcagagaaa gggagagggt ttgagaggga gcaaaagaaa atggtaggcg cgcgtagtta
      421 attcatgcgg ctctcttact ctgtttacat cctagagcta gagtgctcgg ctgcccggct
      481 gagtctcctc cccaccttcc ccaccctccc caccctcccc ataagcgccc tcccgggttc
      541 ccaaagcaga gggcgtgggg gaaaagaaaa aagatcctct ctcgctaatc tccgcccacc
      601 ggccctttat aatgcgaggg tctggacggc tgaggacccc cgagctgtgc tgctcgcggc
      661 cgccaccgcc gggccccggc cgtccctggc tcccctcctg cctcgagaag ggcagggctt
      721 ctcagaggct tggcgggaaa aagaacggag ggagggatcg cgctgagtat aaaagccggt
      781 tttcggggct ttatctaact cgctgtagta attccagcga gaggcagagg gagcgagcgg
      841 gcggccggct agggtggaag agccgggcga gcagagctgc gctgcgggcg tcctgggaag
      901 ggagatccgg agcgaatagg gggcttcgcc tctggcccag ccctcccgct gatcccccag
      961 ccagcggtcc gcaacccttg ccgcatccac gaaactttgc ccatagcagc gggcgggcac
     1021 tttgcactgg aacttacaac acccgagcaa ggacgcgact ctcccgacgc ggggaggcta
     1081 ttctgcccat ttggggacac ttccccgccg ctgccaggac ccgcttctct gaaaggctct
     1141 ccttgcagct gcttagacgc tggatttttt tcgggtagtg gaaaaccagc agcctcccgc
     1201 gacgatgccc ctcaacgtta gcttcaccaa caggaactat gacctcgact acgactcggt
     1261 gcagccgtat ttctactgcg acgaggagga gaacttctac cagcagcagc agcagagcga
     1321 gctgcagccc ccggcgccca gcgaggatat ctggaagaaa ttcgagctgc tgcccacccc
     1381 gcccctgtcc cctagccgcc gctccgggct ctgctcgccc tcctacgttg cggtcacacc
     1441 cttctccctt cggggagaca acgacggcgg tggcgggagc ttctccacgg ccgaccagct
     1501 ggagatggtg accgagctgc tgggaggaga catggtgaac cagagtttca tctgcgaccc
     1561 ggacgacgag accttcatca aaaacatcat catccaggac tgtatgtgga gcggcttctc
     1621 ggccgccgcc aagctcgtct cagagaagct ggcctcctac caggctgcgc gcaaagacag
     1681 cggcagcccg aaccccgccc gcggccacag cgtctgctcc acctccagct tgtacctgca
     1741 ggatctgagc gccgccgcct cagagtgcat cgacccctcg gtggtcttcc cctaccctct
     1801 caacgacagc agctcgccca agtcctgcgc ctcgcaagac tccagcgcct tctctccgtc
     1861 ctcggattct ctgctctcct cgacggagtc ctccccgcag ggcagccccg agcccctggt
     1921 gctccatgag gagacaccgc ccaccaccag cagcgactct ggaggaacaa gaagatgagg
     1981 aagaaatcga tgttgtttct gtggaaaaga ggcaggctcc tggcaaaagg tcagagtctg
     2041 g
//