From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human plasma membrane calcium ATPase isoform 2 (APT2B2) mRNA,
Date: 22 Dec 92 22:44:23 GMT
Distribution: bionet
Checksum: 38567 9

LOCUS       HUMCAATP     4421 bp ss-mRNA            PRI       23-NOV-1992
DEFINITION  Human plasma membrane calcium ATPase isoform 2 (APT2B2) mRNA,
            comlete cds.
ACCESSION   L00620
KEYWORDS    plasma membrane calcium ATPase.
SOURCE      Homo sapiens (library: Lambda gt10) Adult Brain cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 4421)
  AUTHORS   Latif,F., Duh,F.-M., Gnarra,J., Tory,K., Kuzmin,I., Yao,M.,
            Stackhouse,T., Modi,W., Geil,L., Schmidt,L., Li,H., Orcutt,M.,
            Maher,E., Richards,F., Ferguson-Smith,M., Le Paslier,D.,
            Linehan,M., Zbar,B. and Lerman,M.I.
  TITLE     Isolation of candidate genes for the von Hippel-Lindau syndrome:
            Cloning and identification of the plasma membrane Ca++ transporting
            ATPase isoform 2 gene that resides in the von Hipple-Lindau gene
            region
  JOURNAL   Cancer Res. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..18
     3'UTR           3613..4420
     polyA_signal    4304..4309
                     /gene="ATP2B2"
     polyA_site      4421
                     /gene="ATP2B2"
     CDS             19..3615
                     /EC_number="3.6.1.38"
                     /standard_name="HSPMCATP"
                     /gene="ATP2B2"
                     /product="plasma membrane calcium ATPase isoform 2"
                     /codon_start=1
                     /translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
                     KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEA
                     LQDVTLIILEIAAIISLGLSFYHRPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLS
                     VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY
                     GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAV
                     GVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMH
                     KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYV
                     QYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA
                     ICSDKTGTLTTNRMTVVQAYVDDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKIL
                     PPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMST
                     VIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGL
                     RTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITV
                     RMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKL
                     RVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTD
                     VAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQ
                     DSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHA
                     VYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIH
                     GERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGEL
                     VWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRG
                     LNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLE
                     EDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
BASE COUNT     1060 a   1251 c   1214 g    896 t
ORIGIN      
        1 gcaaggaccg cagcaaacat gggtgacatg accaacagcg acttttactc caaaaaccaa
       61 agaaatgagt cgagccatgg gggcgagttc gggtgcacaa tggaggagct ccgctccctc
      121 atggagctgc ggggcactga ggctgtggtc aagatcaagg agacttatgg ggacaccgaa
      181 gccatctgcc ggcgcctcaa aacctcacct gttgaaggtt tgccgggcac cgctccagac
      241 ctggaaaaga gaaagcaaat ttttgggcaa aactttatac ctccaaagaa gccaaaaacc
      301 ttcctgcagc tcgtgtggga ggcgctgcag gacgtgacgc tcatcatcct ggagattgcc
      361 gccatcatct ccctggggct gtccttctac caccgccccg gcgagggcaa cgaaggatgt
      421 gcgacggccc agggtggggc agaggatgaa ggagaggcag aggcaggttg gatcgagggg
      481 gccgccattc tcctctcagt tatctgtgtg gtcctggtca cggccttcaa tgactggagc
      541 aaagagaaac agttccgggg cctgcagagc cgcatcgagc aggaacagaa atttaccgtg
      601 gtccgggctg gccaggtggt ccagatccct gtggctgaga tcgtggttgg ggacatagcc
      661 caggtcaaat atggtgacct cctccctgcc gacggactct tcatccaggg caatgacctc
      721 aagattgatg aaagctccct aactggagag tctgaccagg tgcgcaagtc cgtggacaag
      781 gaccccatgc tgctgtcagg aacccacgtg atggagggct caggacggat gttggtgact
      841 gctgtgggtg tgaactctca gactggcatc atctttaccc tcctgggggc tggtggtgaa
      901 gaggaagaga agaaagacaa aaaagccaaa cagcaggacg gggcagccgc catggagatg
      961 cagcccctca agagtgccga gggcggcgac gctgacgaca ggaagaaggc cagcatgcac
     1021 aagaaggaga agtccgtgct gcagggcaag ctcaccaagc tggctgtgca gatcgggaag
     1081 gcgggcttgg tgatgtcagc catcacggtg atcatcctgg tgctctactt cactgtggac
     1141 accttcgtgg tcaacaagaa gccgtggctg cctgagtgca cgcccgtcta cgtgcagtac
     1201 tttgtcaagt tcttcatcat tggcgtgacg gtgctggtgg tcgccgtgcc cgaggggctc
     1261 cctctggccg tcaccatctc gttggcctat tcggtgaaga aaatgatgaa ggacaacaac
     1321 ctggtacgcc acctggatgc ctgtgagacc atgggcaatg ccacagccat ctgctcagac
     1381 aagacaggca cgctgaccac caatcgcatg acagtggtac aggcctatgt cgacgacgtc
     1441 cactataaag agatccccga ccccagctcc atcaacacca agactatgga gctgctgatc
     1501 aatgccatcg ccatcaacag cgcctacacc accaagattc tgcccccaga gaaggagggc
     1561 gccctgcctc ggcaggtggg caacaagacg gagtgcggcc tgctgggctt cgtgctggac
     1621 ctgaagcagg actacgagcc cgtgcgcagc cagatgccag aggagaagtt gtacaaagtg
     1681 tacaccttca actccgtgcg caagtccatg agcactgtca tcaagctgcc cgacgagagc
     1741 ttccgcatgt acagcaaggg ggcttctgag atcgtgctca agaagtgctg caaaatcctc
     1801 aatggggcgg gagagcctcg tgtcttccgg ccccgcgacc gggacgagat ggtaaagaag
     1861 gtgattgagc ccatggcttg cgatgggctc cgcactatct gcgtggccta ccgcgacttc
     1921 cccagcagcc cggagccgga ctgggacaat gagaatgaca tcctcaacga actcacctgc
     1981 atctgcgtgg tgggcatcga ggacccggtg cggccagagg tcccagaagc catccgcaag
     2041 tgccagcggg caggcatcac ggtccgcatg gtcactggcg acaatatcaa cacggctcgg
     2101 gccatcgcca tcaagtgtgg catcatccat cctggggagg actttctgtg cctcgagggc
     2161 aaggagttca acaggaggat ccgcaacgag aagggggaga ttgagcagga gcgaattgac
     2221 aagatctggc caaagctgcg ggtgctggct cgctcctccc caacggacaa gcataccctg
     2281 gttaaaggca tcatcgacag cacacacact gagcagcggc aggtggtggc cgtgacgggg
     2341 gacgggacca acgacgggcc tgcactcaag aaggccgacg tgggcttcgc catgggcatc
     2401 gcaggcactg acgtggccaa ggaggcctca gacatcatcc tgacagacga caatttcagc
     2461 agcatcgtca aggcagtgat gtggggccgc aacgtctatg acagcatctc caaattcttg
     2521 cagttccagc tcaccgtcaa cgtggtggcc gtgattgtgg ccttcacagg cgcctgcatc
     2581 acgcaggact cccctctgaa ggccgtgcag atgctctggg tgaacctcat catggacacg
     2641 tttgcctcgc tggcactggc cactgagccg cccacggaga ccctgctgct gaggaagccg
     2701 tacggccgca acaagccgct catctccagg accatgatga agaacatcct gggccatgct
     2761 gtctaccagc ttgccctcat cttcaccctg ctctttgttg gcgagaagat gttccagatc
     2821 gacagcggga ggaacgcgcc cctgcattcg ccaccctcag aacattacac catcatcttc
     2881 aacaccttcg tcatgatgca gctcttcaac gagatcaacg cccgcaagat ccacggcgag
     2941 cgcaatgtct ttgacggcat cttccggaac cccatcttct gcaccatcgt gctgggcacc
     3001 tttgccatcc agatagtgat cgtgcagttt ggagggaagc cattcagctg ctctccactg
     3061 cagctggacc agtggatgtg gtgcatattc attgggttag gagagctcgt ttggggccag
     3121 gtcatcgcca ccatcccgac cagcagactc aagttcctca aggaggcagg caggctcaca
     3181 cagaaggagg agatcccgga ggaggagctc aacgaggacg tggaggagat cgaccacgca
     3241 gagcgggagc tgcggcgggg ccagatcctg tggttccgag gcctgaatcg gatccagaca
     3301 cagatccgcg tcgtgaaggc gttccgtagc tctctctatg aaggtttaga aaagcctgaa
     3361 tctcgaacct ccatccataa cttcatggct catcctgaat tccggatcga agattcccag
     3421 ccccacatcc ccctcattga tgacaccgac ctggaagaag atgccgcgct caagcagaac
     3481 tcgagcccgc cgtcatccct caacaagaac aacagcgcca tcgacagtgg gatcaacctg
     3541 acgaccgaca caagcaaatc agctacctct tcaagtccag ggagccccat ccacagcctg
     3601 gagacgtcgc tttagctgag gaccctgtcg cctgcccgcc cgccctcatg gaccccgctg
     3661 tcacccgctt tccgggcacc catccatcca ggcacccaac tcacccaagc agcaacgagc
     3721 aacaatcgga aaccaaatac tggagagaaa accaacgttt ccacccacag accctttctc
     3781 tggctgcgat gctgtttgaa ctctttttca cttcaaggca aggggcggga tctccactgg
     3841 gggcttacgg gagtgagcgg ttttcccaaa acaagccctt cctggctccc acccagacat
     3901 ggaccagcca tgcacccgcc cagtcaccac gtcccccgca tgaatgtact gtacactttc
     3961 aatcctcccc ttgtttggtt tttgggggtt ggggaggggt ttttgtttgt ttgtttgttt
     4021 tcttaggcgg gaactgcaaa cagactcttt tctgagacta tttatccaat ccactggtct
     4081 gtgagttttt gaaacgcttg cacagcatgg tctcagttgt atagattaat ttaataactt
     4141 tttgaaattg cagagcttaa ctcgcctagt agatttgcac caatggaacc gaagaacttc
     4201 atagacactc acaaggttat atccatttct ttgtatctat atcaacgtat acttttccga
     4261 gactgtatac gtccatatag ataggtagat atatatatat atatataaat atatatacat
     4321 ggatatataa agtttctttg ccggcatgtt gccttgtttc cgcttaaatt gctctatttt
     4381 aacttattta tgtcctaaaa gaagaatgta atttgtttac a
//