HDTenEightyP/NetNews huggingface dataset:
From: RR04@bunny.gte.com (Rob Robertson)
Newsgroups: alt.drugs
Subject: Volume Transmission in the Brain
Date: 30 Sep 92 21:01:20 GMT

Organization: GTE Laboratories


  Hey y'all,
     In the July/August 1992 issue of _American Scientist_ I found an 
article that I thought might be of interest to some of you. The title is, 
as you might have guessed, Volume Transmission in the Brain, authored by 
L.F. Agnati of the University of Modena, and B. Bjelke and K. Fuxe of the 
Karolinska Institute, Sweden. In it the authors give a quick review of the 
brain's structure and the mechanism by which information is propagated, 
namely the 'wired' architecture of neurons, synapses, neurotransmitters, 
and so forth.

  They then go on to put forth the theory of information transfer by means 
of electrical currents and chemical signals in the spaces between neurons, 
perhaps being channeled by the electrical potential of the supporting 
cells of the brain which would create 'waveguides' in the brain directing 
a wash of chemicals to certain specific sites. 

  That got me thinking about the effect LSD (as well as other 
psychedelics) has on the brain/senses/mind/whatever. I've spent many years 
learning to SEE purple, not smell it; I've learned to HEAR an A natural, 
not taste it. You get the point. It has been reported by many people that, 
when under the influence of LSD, sounds can be percieved as color, smells 
can generate images, and other stimuli can create seemingly unrelated 
responses. If LSD has the ability (supposedly) of 'crossing the wires' of 
the human senses, by what mechanism does it accomplish this? Does volume transmission play a role in this? 

  If there are any neurophysiologists out there who would care to comment 
I'd be very interested in hearing your ideas. Of course, chemists, 
engineers, census takers, police officers and undergraduate scum are also invited to join in. After all, I'M posting about it, and when it comes to discussions about the brain I'm not  sure if I'm really qualified to have an opinion!

MN, you know what I mean.

Peace,
     Rob
 

Rob Robertson
GTE Laboratories          (617)466-4144 vox
40 Sylvan Rd.                (617)890-9320 fax
Waltham, Mass. 02254
"There is nothing new under the sun..." Eccl. 1:9
Newsgroups: alt.drugs
From: rcarter@nyx.cs.du.edu (Ron Carter)
Subject: Re: schizophrenia versus psychopathy
X-Disclaimer: Nyx is a public access Unix system run by the University
	of Denver for the Denver community.  The University has neither
	control over nor responsibility for the opinions of users.
Organization: Nyx, Public Access Unix at U. of Denver Math/CS dept.
Date: Sun, 4 Oct 92 18:58:07 GMT

pwlbry01@uctvax.uct.ac.za writes:

All sorts of stuff deleted...

>a friend of mine, a nurse, spent four weeks as part of her training in an
>institution. one of the more interesting cases was of a girl who had
>without her knowledge been slipped a tab of LSD.
>she has for the past 3 years been speaking to her father, whenever she hears
>his voice emanating from light fixtures.
>i believe this is a case of schizophrenia, and while i have no knowledge of
>the patients past mental condition it is fairly certain that the accidental
>intake of a substance played at least a contributary part in her apparent
>mental deterioration.

People shouldn't make the mistake of thinking that just because
an individual is (suddenly?) having a -noticeable- manifestation
of a certain behavior, that the `condition' was not pre-existing.

I have yet to see any papers that would suggest that a single
dosage of LSD would cause schizophrenia, or the aggravation of
a schizophrenic state.

LSD -might- be a powerful tool for the diagnosis and therapy (ie
easing interactive conflict) of schizo-affective states, but we
will never know, as long as the WOD hysteria continues. 

Regards,
--
Ron Carter | Director | Center for the Study of Creative Intelligence
"A ... mind stretched by a new idea can never | Denver, Colorado, USA
go back to its original dimensions."  -Holmes | rcarter@nyx.cs.du.edu
From: shirriff@sprite.berkeley.edu (Ken Shirriff)
Newsgroups: alt.drugs
Subject: Re: Nitrous Oxide
Date: 6 Oct 92 00:46:53 GMT
Organization: University of California, Berkeley
NNTP-Posting-Host: hijack.berkeley.edu

In article <1992Oct5.135942.23068@linus.mitre.org> lewis@aera8700.mitre.org (Keith Lewis) writes:
>I've seen the claim that N2O does not react chemically more than once on
>this network, yet nobody seems to be able to explain why it gives you a
>buzz.  This sounds a bit fishy to me.

According to _Introduction to Anesthesia_, Dripps, Eckenhoff, Vandam,
the action of inhalation anesthetics is still not totally understood, but
there are several theories and possible explanations:

"The basic principle that lipid solubility of anesthetics governs anesthetic
action remains viable.  Specifically, the narcotic action of a drug
correlates strongly with its solubility in biologic membranes.  Interactions
of anesthetics with biologic membranes cause expansion of the membrane.  
Membrane expansion by a critical volume of 0.4 per cent results in
anesthesia.  Evidence is available to show that anesthetics selectively
combine with hydrophobic groups in biologic proteins, whether purified or
membrane-associated.  Perhaps these alterations in membrane structure affect
synaptic transmission in the brain, giving rise to anesthesia."
Another possible method is changes in membrane protein structure altering
ion flow.  Action on membranes in mitochondria and endoplasmic reticulum
might also be responsible.
The primary anesthetic action seems to be the synapse.  Anesthetics may
alter the binding of neurotransmitter to specific receptor proteins.
The section concludes that the mechanisms are not necessarily exclusive of
one another.  Multiple mechanisms may be responsible for anesthesia.

Ken Shirriff				shirriff@sprite.Berkeley.EDU
From: R.Bradley.Byrd@dartmouth.edu (R. Bradley Byrd)
Newsgroups: alt.drugs
Subject: Re: Questions on Hawaiian baby woodrose seeds.
Date: 28 Sep 92 18:33:46 GMT
Organization: Dartmouth College, Hanover, NH
X-Posted-From: InterNews1.0a5@newshost.dartmouth.edu

from a FOAF who has taken the seeds, i relay this information:

earlier readings on the net indicated that one need remove the outer
coating by burning and/or sanding, or something to that effect.  my
friend is not sure whether or not his seeds came with this coating, but
he saw no need to take these steps.  instead, all that was done was to
crush the seeds (with a hammer).  it was observed that the inside of
some seeds were brown, while the insides of the majority of the seeds
were white.  he believes, in retrospect, that the brown seeds (very
few) were "bad", and the remainder-- the white ones -- were good.  he
proceeded to ingest 10 seeds (2 were brown, 8 white) and wash them down
with coca cola.  then he ingested 2 dramamines.  
effects began approx. 1 hour after ingestion.
Newsgroups: alt.drugs
From: dyer@spdcc.com (Steve Dyer)
Subject: Re: Nitrous Oxide
Organization: S.P. Dyer Computer Consulting, Cambridge MA
Date: Mon, 5 Oct 1992 23:06:43 GMT

In article <jah.718312226@mits> jah@mits.mdata.fi (Jani A. Heinonen) writes:
>   I stand corrected. So, does nitrous oxide dissolve in the brain as N O
>or is it converted to N ?                                              2 
>                       2

N2O is what acts as an anesthetic--aside from the occasional molecule
oxidizing an essential enzyme or co-enzyme, it is exhaled unchanged.
The point was that nitrogen only acts as an anesthetic at high
pressures.

Isn't it amazing that no one's yet typed NO2? :-)

-- 
Steve Dyer
dyer@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer
From: u8951608@csdvax.csd.unsw.edu.au
Newsgroups: alt.drugs
Subject: Re: LSD recipies
Date: 29 Sep 92 02:07:36 GMT
Organization: University of New South Wales

In article <1992Sep26.160047.34715@ux1.cts.eiu.edu>, cfthb@ux1.cts.eiu.edu (Howard Black) writes:
> In article <1992Sep25.112437.3210@csdvax.csd.unsw.edu.au> u8951608@csdvax.csd.unsw.edu.au writes:
>>
>>You mean diethylamine. It is not watched, and is a common chemical
>>used for a wide range of purposes.
>>
>     How do you know it isn't?  I don't know that it is, but I know that I
> don't know (to coin a phrase).  I am especially curious since you are not
> in the USA.

Well, I must confess that I don't know. I was speaking from what I 
have heard, and from my experience of ordering or buying chemicals,
and speaking to others who have. I know that I can get some if
I want some, as there is plenty lying around my lab. I think the
situation here is pretty much similar to that in the US, or if
anything, more restrictive, because we have a smaller population.
Ordering any chemical here (e.g. methanol!) is difficult if you
do not have a good reason, and specifically a company. Buying LiAlH4 
is sure to attract attention, I am told. But I think that buying 
DEA is no where near as suspicious as buying lysergic acid, e.g.
So, you are right - I also know that I don't know.

BTW, I'd just like to say that it is really refreshing at the
moment to have quite a few chemists who are posting (e.g. yourself, 
St Anthony, and so on) to chat to about such matters.

Jeremy
jeremy@rsc3.anu.edu.au
Organization: Freshman, CIT general, Carnegie Mellon, Pittsburgh, PA
Newsgroups: alt.drugs
Date: Fri,  2 Oct 1992 11:59:24 -0400 
From: Haw Juin Lin <hl27+@andrew.cmu.edu>
Subject: Re: Cocaine

Cocaine is a very strange drug, and I have many friends who are addicts of it.

I have never tried it before, But of what I hear, many things can be happening

One: It would be Comet instead of Cocaine
Two: He got so high that there felt like no effect was taken (SEE BELOW)
Three: He could just be saying that (Not a statement of offense)
Four: He could have some strange tolerance toward Cocaine


Number four is very unlikely....but it may be possible...



AS for the SSEE BELOW....

Cocaine is a Narcotic. Unlike Pot, stimulant, or alcohol, depressant,
the high is completely different. Narcotics make you numb. And under a
given situation, the numbness can effect logical processes, therefore
your friend could be baked off his mind but didn't realize it from a
intellectual point of view.

It could be anything.....


These are only from what I have read and learned...

If there is anything that anybody would like to add to what I wrote,
please do..




Merlin
From: root@bhole.UUCP
Newsgroups: alt.drugs
Subject: Re: Absinthe
Date: Tue, 29 Sep 92 13:16:52 EDT

Re: Re: Absinthe
By: tdm #0 @ecl.psu.edu USEnet      
 
> > Does anyone out there have any information on or experience with
> > Absinthe?  I have heard it mentioned, but have no idea what the effects are
> > Any information would be appreciated.
> Absinthe is a tincture of Wormwood mixed with an alcoholic beverage,
> traditionally anisette.  It was popular in the 19th century in France 
> among poets and other bohemians--Rimbaud blew his mind from it; he was
> an imbecile by his twenties because of absinthe abuse.  (Dead by his
> thirties.) 
> The effects, I hear, are basically narcotic (like codeine) with some
> minor psychedelic effects.  However, wormwood is toxic.  The toxic dose
> is not much more than the dose at which any effect happens, so it is
> dangerous.  Absinthe became illegal for good reason.  I would advise 
> you to stay away from it.

I have a recipe for Absinthe. It is NOT illegal to make or possess in the US
to my knowledge. I drink it from time time and do not find it all that
exciting in the buzz department. Maybe I'm just not drinking enough? 

I had some while I was in Japan in '84. I had 3 shots of this stuff and 3 16oz 
Kirin beers in about an hour. I was soooo drunk I FORGOT to pay the bartab not
to mention some serious stumbling. I felt like I drank at least twice as much
as I did. Woke up the next morning in my own puke. GO NAVY!

Mark
dvss!bhole!root@udel.edu 

Newsgroups: alt.drugs
From: ringo@craft.camp.clarkson.edu (Ringo)
Subject: Re: LSD FlashBacks?
Organization: Clarkson University
Date: Fri, 2 Oct 1992 13:59:23 GMT

"Amy Young Leith" <alyoung@kiwi.ucs.indiana.edu> writes:

>In article <1992Sep24.124627.2620@wkuvx1.bitnet> carltdl@wkuvx1.bitnet writes:

>From my understanding of the research that has been done, no, there
>are no such things as drug induced lsd flashbacks. 

LSD is a nice, friendly, water soluble molecule which is untracable
in the human system approximately three days after ingestion. Levels
of serotonin receptors in the areas of the brain in question are also
back to pre-ingestion levels (They increase dramatically during the trip,
hence the potent short-term tolerance). So that rules out LSD or Serotonin
as the means of flashback.

However, I have met people who INSIST they have had flashbacks. They tend
to be people who tried it once and didn't like it (and certainly didn't
inhale!). 
Amy Leith talked about 'flashing back' to a traumatic experience, which
is a real psychological phenomenon. It is strongly arguable that this is
the mechanism for flashback. There is arguably, however, a neural basis
for the phenomenon. A 10-12 hour journey into the unknown is bound to 
cause some restructuring in the fluid matrix that is your central neural
net. In real words, you'll learn new things. New associations. And new
neural pathways to match them. Consciousness is a fragile, alterable thing,
and learning new patterns due to drug induced states can also have
deleterious effects on what some might call 'your grip on reality.'
Look at and listen to some of the drug gurus from decades ago. They act
just a little different from the rest of us. I've had friends who have 
eaten numerous hits at one time (inc. one who ate a sheet, BION) and
they seem altered. NOT DAMAGED. Altered. They've learned things that
don't necessarily apply to a non-drug-induced state of consciousness.

Arguments?
--John Rescigno
Dept. Of Psychology / Biology
Clarkson University
Nowhere, NY
Newsgroups: alt.drugs
From: aankrom@nyx.cs.du.edu (Anthony Ankrom)
Subject: Re: BSD?
X-Disclaimer: Nyx is a public access Unix system run by the University
	of Denver for the Denver community.  The University has neither
	control over nor responsibility for the opinions of users.
Organization: Nyx, Public Access Unix at U. of Denver Math/CS dept.
Date: Tue, 6 Oct 92 13:43:20 GMT

In article <1992Oct5.171356.28295@nntpd.lkg.dec.com> hughes@gary.enet.dec
com (Gary Hughes - VMS Development) writes:
>
>In article <60871@mimsy.umd.edu>, tms@cs.umd.edu (Tom Swiss (not Swift, 
ot Suiss, Swiss!)) writes...
>>     BSD? Well, it's this flavor of Unix, see, and...
>> 
>>      "There are two major products that come out of Berkeley: LSD and 
NIX.
>>      We don't believe this to be a coincidence."
>>      -- Jeremy S. Anderson
>
>But we do beleive it to be wrong.
>
>Unix of course came from Bell Labs and LSD from Sandoz, neither of which
are
>located at Berkeley.
>
>Who is this Anderson person anyway? He would probably be in line for 'me
e of
>the year award' if there was such a thing.
>
>gary



 This from a guy at VMS development... I'm sure more LSD comes out of
Berkeley than from Sandoz. And BSD UNIX is probably the most popular
flavor. But then do all cars come form Detroit?..

St. Anthony

--
        CH3  O            CH(CH3)2        |      dadaMatrix
           >-P-S-CH2CH2-N<            VX  |                       
    CH3CH2O               CH(CH3)2        |     aankrom@nyx.cs.du.edu
                                          | A kinder gentler lobotomy...
From: bbehlen@soda.berkeley.edu (Vitamin B (Brian Behlendorf))
Newsgroups: alt.drugs
Subject: Re: Why use drugs anyway?
Date: 30 Sep 92 04:58:00 GMT
Organization: U.C. Berkeley, CS Undergraduate Association
NNTP-Posting-Host: soda.berkeley.edu

>> Ted Vessenes writes:
>>
>> I'm really curious what reasons you druggies have for using drugs?
>> I mean, studdies show that drug users die much sooner than other groups
>> of people, and whether or not you can get addicted is not even in question.
>> So why would you want to use drugs?  Email or post back.

Flame bait. :)

Is this post even worth a reply?  Probably not, but I have a midterm tomorrow
so I need something to take my mind off things...

To you, Mr. Vessenes, I ask:  have you ever used Aspirin?  Ever drank a cup
of coffee?  Ever had a beer?  Howbout a chocolate bar?  All these things are
drugs, and one could probably prove that if you consume enough you will die
sooner.  But aha! you and I know there is a safe level at which we can eat
chocolate, we can drink coffee, etc.  It just so happens the Men in Power
haven't outlawed those yet. :)  Similarly, it _has_ been shown, both in
studies and in massive anecdotal evidence, that there is a level at which
"drugs", legal or otherwise, can be taken.  People do not "die sooner".
Come on.  Timothy Leary is 87 years old.  No one here advocates taking 
them at provenly unsafe levels.

There's so much more to say, and I'm sure my post won't be the last one.

	Brian


or as my friend Dana said, to paraphrase, "I think the trouble in this world
is that not enough people have ever tried it"
From: kkruse@matt.ksu.ksu.edu (Korey J. Kruse)
Newsgroups: alt.drugs
Subject: Re: LSD FlashBacks?
Date: 2 Oct 92 09:22:30 GMT
Organization: Kansas State University
NNTP-Posting-Host: matt.ksu.ksu.edu

"Amy Young Leith" <alyoung@kiwi.ucs.indiana.edu> writes:

>In article <1992Sep24.124627.2620@wkuvx1.bitnet> carltdl@wkuvx1.bitnet writes:
>>Hello, I am doing research on the effects of LSD and I all I really
>>need right now is some insight on the Flash Back topic. Myth or fact.
>>What causes it, is it very dangerous, how often it can happen, you
>>know stuff like that. Thanx in advance
>>
>>PS, if this in is a FAQ somewhere could someone please send that to me
>>instead.

>From my understanding of the research that has been done, no, there
>are no such things as drug induced lsd flashbacks. 

>A flashback, which is an emotional animal, can occur when something,
>usually a sense, triggers memories of a previous incident.
> [rest of article deleted]

I guess I might just be an urban legend placebo responder, but I have
had experiences which I would classify as flashbacks.   I do agree with
you that the cause of flashbacks is not some crystal deposit in the
brain or on fat cells or anything else of the nature.   The flashbacks
I had were most probably caused by what you term as an "emotional
animal", but nevertheless I have had flashbacks to lsd trips after
smoking marijuana.   The flashback was not nearly as intense, but it was
still disturbing while it lasted.
From: dlaird@terapin.com (Delbert Laird)
Newsgroups: alt.drugs
Subject: LSD-25
Date: 4 Oct 92 07:30:09 PST
Organization: BBS

I was wondering if anyone knew (or could hazard a guess) to determine if any
effects can be felt using quarter or half hits of LSD?...I'm considering trying
some (on the acclaims of a friend), but I don't want the full-blown experience
yet (so...I'm a wimp, sue me).

dlaird@terapin.com
From: cn0p+@andrew.cmu.edu (Charles D. Nichols)
Newsgroups: alt.drugs
Subject: Re: [anonymous] replacements for 'e'
Date: 1 Oct 92 17:55:42 GMT
Organization: Doctoral student, Biology, Carnegie Mellon, Pittsburgh, PA

>> What do you think that this means in terms of the toxicity of MBDB and has
>> said toxicity ever been tested?  
> 
>Synthesis of this is in PIHKAL. Effects said to be like MDMA, but
>more "stoning" - and a little like MDA. Also check out J.Med Chem
>1982,25,530-535 for Nichols original synthesis and testing. In
>the intro to his paper discussing the non-neurotoxic indan and
>tetralin MDMA derivatives, J.Med.Chem 1990,33,703-710, Nichols
>lumps MBDB and MDMA together, but does not say explicitly that
>MBDB is neurotoxic. I have no idea if this substance has the
>same neurotoxicity of MDA and MDMA, but I wouldn't be surprised.
 

As near as I can remember without looking at the paper describing the
neurotoxicity data of MBDB compared to MDMA and MDA, the toxicity of
MBDB was found to be much less that that of the other two.  However it
is still significant.  I'll post it later.

CDN
Newsgroups: alt.drugs
From: jkp@cs.HUT.FI (Jyrki Kuoppala)
Subject: Re: [anonymous] what the heck
Reply-To: jkp@cs.HUT.FI (Jyrki Kuoppala)
Organization: Helsinki University of Technology, Finland
Date: Sun, 27 Sep 1992 00:16:52 GMT

>>>Remember:  These articles are anonymous, but not secure. 
>>
>>What does this mean, exactly?
>
>Means that if you're worried about your co-workers finding out that you
>post/read alt.drugs the anonymous service is going to be wonderful for you.

No.  Some configurations of sendmail log outgoing messages, and if any
of co-workers are interested it's easy to set such log levels.  More
to the point, many sites have such log levels enabled to debug
sendmail or some other reason, and even if not commands like "mailq"
show what is in the mail queue, ie. who is sending mail to whom.  The
anonymous gateway is currently implemented in such a way that the
publized address shows in the To: field of the mail so everyone who
happens to be looking will see that's you're sending an anonymous
posting to alt.drugs.  If the gateway doesn't do some time-shuffling,
it's easy for that anyone to also find out which one of the postings
was yours.

>However, if you think the trilateral commission is investigating you, and you
>need to make an untraceable post to alt.drugs, you are screwed.  If someone
>breaks into cupid.sai.com and steals the ap.address <-> real address file,
>they'd know who posted every single anonymous article.

Why have such a log file?  For replying to mail, yes - but I would
guess for many posters replies just on the newsgroup would be
sufficient.  An alternative anonymous mail machine with no such logs
would seem to be an improvement in the security level.

I don't want to sound negative - I think it's good to have an
anonymous posting service, but it's also good to be aware of the
vulnerabilities.

//Jyrki
From: mtymp06@staff.tc.umn.edu (Ted Vessenes)
Newsgroups: alt.drugs
Subject: Why use drugs anyway?
Summary: Why use drugs anyway?
Keywords: drugs, delete, legalization
Date: 29 Sep 92 22:04:18 GMT
Distribution: national
Organization: University of Minnesota

I'm really curious what reasons you druggies have for using drugs?
I mean, studdies show that drug users die much sooner than other groups
of people, and whether or not you can get addicted is not even in question.
So why would you want to use drugs?  Email or post back.
-- 
_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_
| Disclaimer:  I said it; I meant it; so sue me.  |    Gravity is a myth;     |
| Ted Vessenes (mtymp06@epx.cis.umn.edu)          |     the Earth sucks.      |
-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-_-
From: bprofane@netcom.com (Gert Niewahr)
Newsgroups: alt.drugs
Subject: Re: Mescaline- question
Date: 6 Oct 92 08:07:31 GMT
Organization: Netcom - Online Communication Services  (408 241-9760 guest)

In article <BvC0Jw.MH0@acsu.buffalo.edu> v079ql9q@ubvmsb.cc.buffalo.edu (I got a Catholic Block.....) writes:
>
>A FOAF told me that the effects are similiar to acid, but not as harsh (esp the
>crash) and that mescaline was a peyote derivative.  Is this true?

No and yes.  Mescaline is the active ingredient in peyote cactus.
The physiological effects (what Shulgin calls the body load) of
mescaline are a lot heavier than LSD: Hypothermia, sweating, muscle
aches.  Severe nausea is almost unavoidable.  Frankly, I don't
think the psychedelic experience is worth the puking.
From: Ben Masel <bmasel@igc.apc.org>
Newsgroups: alt.drugs
Date: 30 Sep 92 23:35 PDT
Subject: Re: Smoking ephedrine?
Nf-ID: #R:kaz.717797783@vincent1.iastate.e:-663378987:cdp:1301300186:000:98
Nf-From: cdp.UUCP!bmasel    Sep 30 23:35:00 1992


Dont know about the pills. i have smoked herbal ephedra. Stop
after each hit to evaluate dosage!.