From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens mRNA for NuMA protein
Date: 10 Apr 92 10:06:33 GMT
Distribution: bionet
Checksum: 43833    13

LOCUS       HUMNUMAMR    7154 bp ss-mRNA            PRI       10-APR-1992
DEFINITION  H.sapiens mRNA for NuMA protein
ACCESSION   Z11583
KEYWORDS    NuMA protein.
SOURCE      Homo sapiens RNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 7154)
  AUTHORS   Snyder,M.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 7154)
  AUTHORS   Yang,C.H., Lambie,E.J. and Snyder,M.
  TITLE     NuMA: an unusually long coiled-coil related protein in the
            mammalian nucleus
  JOURNAL   J. Cell Biol. 116, 1303-1317 (1992)
  STANDARD  full automatic
COMMENT     *source: clone_library=Placental cDNA, HeLa PCR; *source: clone=
            lambda 240-1, lambda 240-2, PCR1; *source: is_macronuclear=N;
            *source: is_proviral=N; *source: is_germline=N;
            From EMBL    entry HSNUMAMR;  dated 27-MAR-1992.
FEATURES             Location/Qualifiers
     CDS             157..6504
                     /product="NuMA protein"
                     /translation="MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIH
                     GTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLL
                     LYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTC
                     SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRR
                     LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK
                     ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL
                     QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE
                     HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL
                     LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT
                     TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ
                     LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
                     QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS
                     EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK
                     AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT
                     AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV
                     AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK
                     EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER
                     EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL
                     EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK
                     QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL
                     ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK
                     AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS
                     QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE
                     RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE
                     KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ
                     LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV
                     QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE
                     ELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY
                     KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE
                     AEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLD
                     LSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQA
                     PLESSLDSLGDVFQDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAP
                     ASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN
                     SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKT
                     GDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTP
                     RDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALS
                     KASPNTRSGTRRSPRIATTTASAATAAAIGATPRAKGKAKH"
     misc_feature    802..5257
                     /note="predicted coiled-coil coding region"
BASE COUNT     1785 a   1985 c   2268 g   1116 t
ORIGIN
        1 acgaagaggt acgattccgg agaatcgcga ggcagagcgg gagcgcgcag ccaggtggaa
       61 actaattcta agccagactg ctggagatca ccctgttcta gtgtgtggag gcttccacca
      121 ggaggcgcat tggagtgact gtctggcatc accaagatga cactccacgc cacccggggg
      181 gctgcactcc tctcttgggt gaacagtcta cacgtggctg accctgtgga ggctgtgctg
      241 cagctccagg actgcagcat cttcatcaag atcattgaca gaatccatgg cactgaagag
      301 ggacagcaaa tcttgaagca gccggtgtca gagagactgg actttgtgtg cagttttctg
      361 cagaaaaatc gaaaacatcc ctcttcccca gaatgcctgg tatctgcaca gaaggtgcta
      421 gagggatcag agctggaact ggcgaagatg accatgctgc tcttatacca ctctaccatg
      481 agctccaaaa gtcccaggga ctgggaacag tttgaatata aaattcaggc tgagttggct
      541 gtcattctta aatttgtgct ggaccatgag gacgggctaa accttaatga ggacctagag
      601 aacttcctac agaaagctcc tgtgccttct acctgttcta gcacattccc tgaagagctc
      661 tccccaccta gccaccaggc caagagggag attcgcttcc tagagctaca gaaggttgcc
      721 tcctcttcca gtgggaacaa ctttctctca ggttctccag cttctcccat gggtgatatc
      781 ctgcagaccc cacagttcca gatgagacgg ctgaagaagc agcttgctga tgagagaagt
      841 aatagggatg agctggagct ggagctagct gagaaccgca agctcctcac cgagaaggat
      901 gcacagatag ccatgatgca gcagcgcatt gaccgcctag ccctgctgaa tgagaagcag
      961 gcggccagcc cactggagcc caaggagctt gaggagctgc gtgacaagaa tgagagcctt
     1021 accatgcggc tgcatgaaac cctgaagcag tgccaggacc tgaagacaga gaagagccag
     1081 atggatcgca aaatcaacca gctttcggag gagaatggag acctttcctt taagctgcgg
     1141 gagtttgcca gtcatctgca gcagctacag gatgccctca atgagctgac ggaggagcac
     1201 agcaaggcca ctcaggagtg gctagagaag caggcccagc tggagaagga gctcagcgca
     1261 gccctgcagg acaagaaatg ccttgaagag aagaacgaaa tccttcaggg aaaactttca
     1321 cagctggaag aacacttgtc ccagctgcag gataacccac cccaggagaa gggcgaggtg
     1381 ctgggtgatg tcttgcagct ggaaaccttg aagcaagagg cagccactct tgctgcaaac
     1441 aacacacagc tccaagccag ggtagagatg ctggagactg agcgaggcca gcaggaagcc
     1501 aagctgcttg ctgagcgggg ccacttcgaa gaagaaaagc agcagctgtc tagcctgatc
     1561 actgacctgc agagctccat ctccaacctc agccaggcca aggaagagct ggagcaggcc
     1621 tcccaggctc atggggcccg gttgactgcc caggtggcct ctctgacctc tgagctcacc
     1681 acactcaatg ccaccatcca gcaacaggat caagaactgg ctggcctgaa gcagcaggcc
     1741 aaagagaagc aggcccagct agcacagacc ctccaacagc aagaacaggc ctcccagggc
     1801 ctccgccacc aggtggagca gctaagcagt agcctgaagc agaaggagca gcagttgaag
     1861 gaggtagcgg agaagcagga ggcaactagg caggaccatg cccagcaact ggccactgct
     1921 gcagaggagc gagaggcctc cttaagggag cgggatgcgg ctctcaagca gctggaggca
     1981 ctggagaagg agaaggctgc caagctggag attctgcagc agcaacttca ggtggctaat
     2041 gaagcccggg acagtgccca gacctcagtg acacaggccc agcgggagaa ggcagagctg
     2101 agccggaagg tggaggaact ccaggcctgt gttgagacag cccgccagga acagcatgag
     2161 gcccaggccc aggttgcaga gctagagttg cagctgcggt ctgagcagca aaaagcaact
     2221 gagaaagaaa gggtggccca ggagaaggac cagctccagg agcagctcca ggccctcaaa
     2281 gagtccttga aggtcaccaa gggcagcctt gaagaggaga agcgcagggc tgcagatgcc
     2341 ctggaagagc agcagcgttg tatctctgag ctgaaggcag agacccgaag cctggtggag
     2401 cagcataagc gggaacgaaa ggagctggaa gaagagaggg ctgggcgcaa ggggctggag
     2461 gctcgattac agcagcttgg ggaggcccat caggctgaga ctgaagtcct gcggcgggag
     2521 ctggcagagg ccatggctgc ccagcacaca gctgagagtg agtgtgagca gctcgtcaaa
     2581 gaagtagctg cctggcgtga gcggtatgag gatagccagc aagaggaggc acagtatggc
     2641 gccatgttcc aggaacagct gatgactttg aaggaggaat gtgagaaggc ccgccaggag
     2701 ctgcaggagg caaaggagaa ggtggcaggc atagaatccc acagcgagct ccagataagc
     2761 cggcagcaga acgaactagc tgagctccat gccaacctgg ccagagcact ccagcaggtc
     2821 caagagaagg aagtcagggc ccagaagctt gcagatgacc tctccactct gcaggaaaag
     2881 atggctgcca ccagcaaaga ggtggcccgc ttggagacct tggtgcgcaa ggcaggtgag
     2941 cagcaggaaa cagcctcccg ggagttagtc aaggagcctg cgagggcagg agacagacag
     3001 cccgagtggc tggaagagca acagggacgc cagttctgca gcacacaggc agcgctgcag
     3061 gctatggagc gggaggcaga gcagatgggc aatgagctgg aacggctgcg ggccgcgctg
     3121 atggagagcc aggggcagca gcaggaggag cgtgggcagc aggaaaggga ggtggcgcgg
     3181 ctgacccagg agcggggccg tgcccaggct gaccttgccc tggagaaggc ggccagagca
     3241 gagcttgaga tgcggctgca gaacgccctc aacgagcagc gtgtggagtt cgctaccctg
     3301 caagaggcac tggctcatgc cctgacggaa aaggaaggca aggaccagga gttggccaag
     3361 cttcgtggtc tggaggcagc ccagataaaa gagctggagg aacttcggca aaccgtgaag
     3421 caactgaagg aacagctggc taagaaagaa aaggagcacg catctggctc aggagcccaa
     3481 tctgaggctg ctggcaggac agagccaaca ggccccaagc tggaggcact gcgggcagag
     3541 gtgagcaagc tggaacagca atgccagaag cagcaggagc aggctgacag cctggaacgc
     3601 agcctcgagg ctgagcgggc ctcccgggct gagcgggaca gtgctctgga gactctgcag
     3661 ggccagttag aggagaaggc ccaggagcta gggcacagtc agagtgcctt agcctcggcc
     3721 caacgggagt tggctgcctt ccgcaccaag gtacaagacc acagcaaggc tgaagatgag
     3781 tggaaggccc aggtggcccg gggccggcaa gaggctgaga ggaaaaatag cctcatcagc
     3841 agcttggagg aggaggtgtc catcctgaat cgccaggtcc tggagaagga gggggagagc
     3901 aaggagttga agcggctggt gatggccgag tcagagaaga gccagaagct ggaggagagg
     3961 ctgcgcctgc tgcaggcaga gacagccagc aacagtgcca gagctgcaga acgcagctct
     4021 gctctgcggg aggaggtgca gagcctccgg gaggaggctg agaaacagcg ggtggcttca
     4081 gagaacctgc ggcaggagct gacctcacag gctgagcgtg cggaggagct gggccaagaa
     4141 ttgaaggcgt ggcaggagaa gttcttccag aaagagcagg ccctctccac cctgcagctc
     4201 gagcacacca gcacacaggc cctggtgagt gagctgctgc cagctaagca cctctgccag
     4261 cagctgcagg ccgagcaggc cgctgccgag aaacgccacc gtgaggagct ggagcagagc
     4321 aagcaggccg ctgggggact gcgggcagag ctgctgcggg cccagcggga gcttggggag
     4381 ctgattcctc tgcggcagaa ggtggcagag caggagcgaa cagctcagca gctgcgggca
     4441 gagaaggcca gctatgcaga gcagctgagc atgctgaaga aggcgcatgg cctgctggca
     4501 gaggagaacc gggggctggg tgagcgggcc aaccttggcc ggcagtttct ggaagtggag
     4561 ttggaccagg cccgggagaa gtatgtccaa gagttggcag ccgtacgtgc tgatgctgag
     4621 acccgtctgg ctgaggtgca gcgagaagca cagagcactg cccgggagct ggaggtgatg
     4681 actgccaagt atgagggtgc caaggtcaag gtcctggagg agaggcagcg gttccaggaa
     4741 gagaggcaga aactcactgc ccaggtggag cagctagagg tatttcagag agagcaaact
     4801 aagcaggtgg aagaactgag taagaaactg gctgactctg accaagccag caaggtgcag
     4861 cagcagaagc tgaaggctgt ccaggctcag ggaggcgaga gccagcagga ggcccagcgc
     4921 ctccaggccc agctgaatga actgcaagcc cagttgagcc agaaggagca ggcagctgag
     4981 cactataagc tgcagatgga gaaagccaaa acacattatg atgccaagaa gcagcagaac
     5041 caagagctgc aggagcagct gcggagcctg gagcagctgc agaaggaaaa caaagagctg
     5101 cgagctgaag ctgaacggct gggccatgag ctacagcagg ctgggctgaa gaccaaggag
     5161 gctgaacaga cctgccgcca ccttactgcc caggtgcgca gcctggaggc acaggttgcc
     5221 catgcagacc agcagcttcg agacctgggc aaattccagg tggcaactga tgctttaaag
     5281 agccgtgagc cccaggctaa gccccagctg gacttgagta ttgacagcct ggatctgagc
     5341 tgcgaggagg ggaccccact cagtatcacc agcaagctgc ctcgtaccca gccagacggc
     5401 accagcgtcc ctggagaacc agcctcacct atctcccagc gcctgccccc caaggtagaa
     5461 tccctggaga gtctctactt cactcccatc cctgctcgga gtcaggcccc cctggagagc
     5521 agcctggact ccctgggaga cgtcttccag gactcgggtc gtaagacccg ctccgctcgt
     5581 cggcgcacca cgcagatcat caacatcacc atgaccaaga agctagatgt ggaagagcca
     5641 gacagcgcca actcatcgtt ctacagcacg cggtctgctc ctgcttccca ggctagcctg
     5701 cgagccacct cctctactca gtctctagct cgcctgggtt ctcccgatta tggcaactca
     5761 gccctgctca gcttgcctgg ctaccgcccc accactcgca gttctgctcg tcgttcccag
     5821 gccggggtgt ccagtggggc ccctccagga aggaacagct tctacatggg cacttgccag
     5881 gatgagcctg agcagctgga tgactggaac cgcattgcag agctgcagca gcgcaatcga
     5941 gtgtgccccc cacatctgaa gacctgctat cccctggagt ccaggccttc cctgagcctg
     6001 ggcaccatca cagatgagga gatgaaaact ggagaccccc aagagaccct gcgccgagcc
     6061 agcatgcagc caatccagat agccgagggc actggcatca ccacccggca gcagcgtaaa
     6121 cgggtctccc tagagcccca ccagggccct ggaactcctg agtctaagaa ggccaccagc
     6181 tgtttcccac gccccatgac tccccgagac cgacatgaag ggcgcaaaca gagcactact
     6241 gaggcccaga agaaagcagc tccagcttct actaaacagg ctgaccggcg ccagtcgatg
     6301 gccttcagca tcctcaacac acccaagaag ctagggaaca gccttctgcg gcggggagcc
     6361 tcaaagaagg ccctgtccaa ggcttccccc aacactcgca gtggaacccg ccgttctccg
     6421 cgcattgcca ccaccacagc cagcgccgcc actgctgccg ccattggtgc cacccctcga
     6481 gccaagggca aggcaaagca ctaaagggcc agtaccagtg agtggcccca cctgtgtccc
     6541 cgatgctgcc gtcacctggt cctccgccta ctgtccctct cagtgccttc tctcagctcc
     6601 caggccaaca gtagccaaac ccctagagac agtgatgcct gcccgcaccc tggcctggtc
     6661 cctggtcctt cactggcgcc ttctcggagc tggcccaggg ggcctggagc atggacagtg
     6721 tgggcgctct ccctaccttg cctccttttt tcttaaagca aagtcacttc tccatcacaa
     6781 ccagatttga ggctggtttt gatggctggg tccttgggcc tggccagtct tcctcttagc
     6841 ctctggatct agaagggacc ataagaggag taggccctgg ttcctgctgt cctggtggct
     6901 gggcccagca ggggccctca ctcttgaagt ccaggactgg gtctgacctg gtgggagcac
     6961 ctgccagagg atgctctttc ccaggacgga tgggccctgt gtctcaggag tggggttggg
     7021 ggacagcctt cagcagcagc tcacacccta ccttccccag acttgcactg gggtgggatt
     7081 tggagtgatg ggaaggtttt taagggccgg ggatggatct tttctaaatg ttattacttg
     7141 taaatcccga attc
//