From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse dystrophin mRNA, exons 1-7 and complete cds.
Date: 31 Dec 92 01:30:42 GMT
Distribution: bionet
Checksum: 54254 27

LOCUS       MUSDYSA     13815 bp ss-mRNA            ROD       16-DEC-1992
DEFINITION  Mouse dystrophin mRNA, exons 1-7 and complete cds.
ACCESSION   M68859
KEYWORDS    dystrophin.
SOURCE      Mus musculus (strain C57BL/10) (library: lambda zap and lambda gt11
            cDNA libraries) adult skeletal muscle cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (sites)
  AUTHORS   Kunkel,L.M., Feener,C., Monaco,A.P., Bertelson,C.J., Hoffman,E.P.
            and Koenig,M.
  TITLE     Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and
            preliminary genomic organization of the DMD gene in normal and
            affected individuals
  JOURNAL   Cell 50, 509-517 (1987)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Hoffman,E.P., Monaco,A.P., Feener,C.C. and Kunkel,L.M.
  TITLE     Conservation of the Duchenne muscular dystrophy gene in mice and
            humans
  JOURNAL   Science 238, 347-350 (1987)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 13815)
  AUTHORS   Bies,R.D., Phelps,S.F., Cortez,M.D., Roberts,R., Caskey,C.T. and
            Chamberlain,J.S.
  TITLE     Human and murine dystrophin mRNA transcripts are differentially
            expressed during skeletal muscle, heart, and brain development
  JOURNAL   Nucleic Acids Res. 20, 1725-1731 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            <1..251
                     /number=1
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="cloned region"
     mRNA            <1..13815
                     /gene="dystrophin"
                     /note="major muscle isoform"
     conflict        replace(214,"t")
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     conflict        replace(733,"a")
                     /evidence="EXPERIMENTAL"
                     /citation=[1]
     variation       replace(835,"t")
                     /phenotype="mdx mutant strains 467 and 551"
                     /gene="dystrophin"
     conflict        replace(2250,"t")
                     /evidence="EXPERIMENTAL"
                     /citation=[2]
     mutation        replace(3203,"t")
                     /phenotype="mdx mutation"
                     /gene="dystrophin"
     exon            10424..10462
                     /number=2
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     exon            10463..10528
                     /number=3
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     exon            10529..10594
                     /number=4
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     exon            10595..10753
                     /number=5
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     exon            10754..11221
                     /number=6
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     exon            11222..11253
                     /number=7
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
                     /note="alternatively spliced"
     misc_feature    11341..11343
                     /phenotype="embryonic isoform"
                     /standard_name="embryonic stop codon"
                     /gene="dystrophin"
     polyA_site      13815
                     /gene="dystrophin"
                     /evidence="EXPERIMENTAL"
     CDS             221..11257
                     /gene="dystrophin"
                     /note="mutation results in a mild muscular dystrophy
                     analogous to BMD; homologue of human Duchenne/Becker
                     muscular dystrophy locus"
                     /product="dystrophin major muscle isoform"
                     /codon_start=1
                     /translation="MLWWEEVEDCYEREDVQKKTFTKWINAQFSKFGKQHIDNLFSDL
                     QDGKRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVDG
                     NHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFT
                     SSWSDGLALNALIHSHRPDLFDWNSVVSQHSATQRLEHAFNIAKCQLGIEKLLDPEDV
                     ATTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRTSSKVTREEHFQLHHQMHYS
                     QQITVSLAQGYEQTSSSPKPRFKSYAFTQAAYVATSDSTQSPYPSQHLEAPRDKSLDS
                     SLMETEVNLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMMDLT
                     SHQGLVGNVLQLGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKV
                     LMDLQNQKLKELDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVR
                     VNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQHF
                     TEEQCLFSTWLSEKEDAMKNIQTSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSS
                     LNQDLLSALKNKSVTQKMEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPSLTQTT
                     VMETVTMVTTREQIMVKHAQEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRS
                     EAVLQSSEFAVYRKEGNISDLQEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGV
                     NAESIRQASEQLNSRWTEFCQLLSERVNWLEYQTNIITFYNQLQQLEQMTTTAENLLK
                     TQSTTLSEPTAIKSQLKICKDEVNRLSALQPQIEQLKIQSLQLKEKGQGPMFLDADFV
                     AFTNHFNHIFDGVRAKEKELQTIFDTLPPMRYQETMSSIRTWIQQSESKLSVPYLSVT
                     EYEIMEERLGKLQALQSSLKEQQNGFNYLSDTVKEMAKKAPSEICQKYLSEFEEIEGH
                     WKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDVFLKEEWPALGDAEILKK
                     QLKQCRLLVGDIQTIQPSLNSVNEGGQKIKSEAELEFASRLETELRELNTQWDHICRQ
                     VYTRKEALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAVEEMKR
                     AKEEALQKETKVKLLTETVNSVIAHAPPSAQEALKKELETLTTNYQWLCTRLNGKCKT
                     LEEVWACWHELLSYLEKANKWLNEVELKLKTMENVPAGPEEITEVLESLENLMHHSEE
                     NPNQIRLLAQTLTDGGVMDELINEELETFNSRWRELHEEAVRKQKLLEQSIQSAQEIE
                     KSLHLIQESLEFIDKQLAAYITDKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK
                     DANQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLEESKMILDEVKMHLPALETKS
                     VEQEVIQSQLSHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL
                     HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDTELTKRSAVEGMPSNLD
                     SEVAWGKATQKEIEKQKAHLKSVTELGESLKMVLGKKETLVEDKLSLLNSNWIAVTSR
                     VEEWLNLLLEYQKHMETFDQNIEQITKWIIHADELLDESEKKKPQQKEDILKRLKAEM
                     NDMRPKVDSTRDQAAKLMANRGDHCRKVVEPQISELNRRFAAISHRIKTGKASIPLKE
                     LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITD
                     ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDEIEK
                     KLASLPEPRDERKLKEIDRELQKKKEELNAVRRQAEGLSENGAAMAVEPTQIQLSKRW
                     RQIESNFAQFRRLNFAQIHTLHEETMVVTTEDMPLDVSYVPSTYLTEISHILQALSEV
                     DHLLNTPELCAKDFEDLFKQEESLKNIKDNLQQISGRIDIIHKKKTAALQSATSMEKV
                     KVQEAVAQMDFQGEKLHRMYKERQGRFDRSVEKWRHFHYDMKVFNQWLNEVEQFFKKT
                     QNPENWEHAKYKWYLKELQDGIGQRQAVVRTLNATGEEIIQQSSKTDVNILQEKLGSL
                     SLRWHDICKELAERRKRIEEQKNVLSEFQRDLNEFVLWLEEADNIAITPLGDEQQLKE
                     QLEQVKLLAEELPLRQGILKQLNETGGAVLVSAPIRPEEQDKLEKKLKQTNLQWIKVS
                     RALPEKQGELEVHLKDFRQLEEQLDHLLLWVSPIRNQLEIYNQPSQAGPFDIKEIEVT
                     VHGKQADVERLLSKGQHLYKEKPSTQPVKRKLEDLRSEWEAVNHLLRELRTKQPDRAP
                     GLSTTGASASQTVTLVTQSVVTKETVISKLEMPSSLLLEVPALADFNRAWTELTDWLS
                     LLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQRRPQLEELITAAQNLKNKTSNQE
                     ARTIITDRIERIQIQWDEVQEQLQNRRQQLNEMLKDSTQWLEAKEEAEQVIGQVRGKL
                     DSWKEGPHTVDAIQKKITETKQLAKDLRQRQISVDVANDLALKLLRDYSADDTRKVHM
                     ITENINTSWGNIHKRVSEQEAALEETHRLLQQFPLDLEKFLSWITEAETTANVLQDAS
                     RKEKLLEDSRGVRELMKPWQDLQGEIETHTDIYHNLDENGQKILRSLEGSDEAPLLQR
                     RLDNMNFKWSELQKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG
                     GDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP
                     EERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDEALERLQELQEAADELDLKLR
                     QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVNRVNDLAHQLTTLGIQL
                     SPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP
                     NKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLS
                     LSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
                     NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDS
                     IQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLH
                     RVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMV
                     EYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINF
                     WPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
                     HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
                     EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
                     LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSESMGEEDLLS
                     PPQDTSTGLEEVMEQLNNSFPSSRGRNAPGKPMREDTM"
BASE COUNT     4577 a   2718 c   3026 g   3494 t
ORIGIN      
        1 cctcactcac ttgcccctta caggactcag ctcttgaagg caatagcttt atagaaaaaa
       61 cgaataggaa gacttgaagt gctatttttt tttttttttt tgtcaaggct gctgaagttt
      121 attggcttct catcgtacct aagcctcctg gagcaataaa actgggagaa acttttacca
      181 agatttttat ccctgccttg atatatactt tttcttccaa atgctttggt gggaagaagt
      241 agaggactgt tatgaaagag aagatgttca aaagaaaaca ttcacaaaat ggataaatgc
      301 acaattttct aagtttggaa agcaacacat agacaacctc ttcagtgacc tgcaggatgg
      361 aaaacgcctc ctagacctct tggaaggcct tacagggcaa aaactgccaa aagaaaaggg
      421 atctacaaga gttcatgccc tgaacaatgt caacaaggca ctgcgggtct tacagaaaaa
      481 taatgttgat ttagtgaata taggaagcac tgacatagtg gatggaaatc ataaactcac
      541 tcttggtttg atttggaata taatcctcca ctggcaggtc aaaaatgtga tgaaaactat
      601 catggctgga ttgcagcaaa ccaacagtga aaagattctt ctgagctggg ttcgacagtc
      661 aacacgtaat tatccacagg ttaacgtcat caacttcacc tctagctggt ccgacgggtt
      721 ggctttgaat gctcttatcc atagtcacag gcccgacctg tttgattgga atagtgtggt
      781 ttcacagcac tcagccaccc aaagactgga acatgccttc aacattgcaa aatgccagtt
      841 aggcatagaa aaacttcttg atcctgaaga tgttgctacc acttatccag acaagaagtc
      901 catcttaatg tacatcacat cactctttca agttttgcca caacaagtga gcattgaagc
      961 cattcaagaa gtggaaatgt tgcccaggac atcttcaaaa gtaactagag aagaacattt
     1021 tcaattacat caccagatgc attactctca acagatcaca gtcagtctag cacagggcta
     1081 tgaacaaact tcttcatctc ctaagcctcg attcaagagt tatgccttca cacaggctgc
     1141 ttatgttgcc acctctgatt ccacacagag cccctatcct tcacagcatt tggaagctcc
     1201 cagagacaag tcacttgaca gttcattgat ggagacggaa gtaaatctgg atagttacca
     1261 aactgcttta gaagaagtac tttcatggct tctttctgcc gaggatacat tgcgagcaca
     1321 aggagagatt tcaaatgatg ttgaagaagt gaaagaacag tttcatgctc atgagggatt
     1381 catgatggat ctgacatctc atcaaggact tgttggtaat gttctacagt taggaagtca
     1441 actagttgga aaagggaaat tatcagaaga tgaagaagct gaagtgcaag aacaaatgaa
     1501 tctcctaaat tcaagatggg aatgtctcag ggtagctagc atggaaaaac aaagcaaatt
     1561 acacaaagtt ctaatggatc tccagaatca gaaattaaaa gaactagatg actggttaac
     1621 aaaaactgaa gagagaacta agaaaatgga ggaagagccc tttggacctg atcttgaaga
     1681 tctaaaatgc caagtacaac aacataaggt gcttcaagaa gatctagaac aggagcaggt
     1741 cagggtcaac tcgctcactc acatggtagt agtggttgat gaatccagcg gtgatcatgc
     1801 aacagctgct ttggaagaac aacttaaggt actgggagat cgatgggcaa atatctgcag
     1861 atggactgaa gaccgctgga ttgttttaca agatattctt ctaaaatggc agcattttac
     1921 tgaagaacag tgccttttta gtacatggct ttcagaaaaa gaagatgcaa tgaagaacat
     1981 tcagacaagt ggctttaaag atcaaaatga aatgatgtca agtcttcaca aaatatctac
     2041 tttaaaaata gatctagaaa agaaaaagcc aaccatggaa aaactaagtt cactcaatca
     2101 agatctactt tcggcactga aaaataagtc agtgactcaa aagatggaaa tctggatgga
     2161 aaactttgca caacgttggg acaatttaac ccaaaaactt gaaaagagtt cagcacaaat
     2221 ttcacaggct gtcaccacca ctcaaccatc cctaacacag acaactgtaa tggaaacggt
     2281 aactatggtg accacaaggg aacaaatcat ggtaaaacat gcccaagagg aacttccacc
     2341 accacctcct caaaagaaga ggcagataac tgtggattct gaactcagga aaaggttgga
     2401 tgtcgatata actgaacttc acagttggat tactcgttca gaagctgtat tacagagttc
     2461 tgaatttgca gtctatcgaa aagaaggcaa catctcagac ttgcaagaaa aagtcaatgc
     2521 catagcacga gaaaaagcag agaagttcag aaaactgcaa gatgccagca gatcagctca
     2581 ggccctggtg gaacagatgg caaatgaggg tgttaatgct gaaagtatca gacaagcttc
     2641 agaacaactg aacagccggt ggacagaatt ctgccaattg ctgagtgaga gagttaactg
     2701 gctagagtat caaaccaaca tcattacctt ttataatcag ctacaacaat tggaacagat
     2761 gacaactact gccgaaaact tgttgaaaac ccagtctacc accctatcag agccaacagc
     2821 aattaaaagc cagttaaaaa tttgtaagga tgaagtcaac agattgtcag ctcttcagcc
     2881 tcaaattgag caattaaaaa ttcagagtct acaactgaaa gaaaagggac aggggccaat
     2941 gtttctggat gcagactttg tggcctttac taatcatttt aaccacatct ttgatggtgt
     3001 gagggccaaa gagaaagagc tacagacaat ttttgacact ttaccaccaa tgcgctatca
     3061 ggagacaatg agtagcatca ggacgtggat ccagcagtca gaaagcaaac tctctgtacc
     3121 ttatcttagt gttactgaat atgaaataat ggaggagaga ctcgggaaat tacaggctct
     3181 gcaaagttct ttgaaagagc aacaaaatgg cttcaactat ctgagtgaca ctgtgaagga
     3241 gatggccaag aaagcacctt cagaaatatg ccagaaatat ctgtcagaat ttgaagagat
     3301 tgaggggcac tggaagaaac tttcctccca gttggtggaa agctgccaaa agctagaaga
     3361 acatatgaat aaacttcgaa aatttcagaa tcacataaaa accttacaga aatggatggc
     3421 tgaagttgat gttttcctga aagaggaatg gcctgccctg ggggatgctg aaatcctgaa
     3481 aaaacagctc aaacaatgca gacttttagt tggtgatatt caaacaattc agcccagttt
     3541 aaatagtgtt aatgaaggtg ggcagaagat aaagagtgaa gctgaacttg agtttgcatc
     3601 cagactggag acagaactta gagagcttaa cactcagtgg gatcacatat gccgccaggt
     3661 ctacaccaga aaggaagcct taaaggcagg tttggataaa accgtaagcc tccaaaaaga
     3721 tctatcagag atgcatgagt ggatgacaca agctgaagaa gaatatctag agagagattt
     3781 tgaatataaa actccagatg aattacagac tgctgttgaa gaaatgaaga gagctaaaga
     3841 agaggcacta caaaaagaaa ctaaagtgaa actccttact gagactgtaa atagtgtaat
     3901 agctcacgct ccaccctcag cacaagaggc cttaaaaaag gaacttgaaa ctctgaccac
     3961 caactaccaa tggctgtgca ccaggctgaa tggaaaatgc aaaactttgg aagaagtttg
     4021 ggcatgttgg catgagttat tgtcatattt agagaaagca aacaagtggc tcaatgaagt
     4081 agaattgaaa cttaaaacca tggaaaatgt tcctgcagga cctgaggaaa tcactgaagt
     4141 gctagaatct cttgaaaatc tgatgcatca ttcagaggag aacccaaatc agattcgtct
     4201 attggcacag actcttacag atggaggagt catggatgaa ctgatcaatg aggagcttga
     4261 gacgtttaat tctcgttgga gggaactaca tgaagaggct gtgaggaaac aaaagttgct
     4321 tgaacagagt atccagtctg cccaggaaat tgaaaagtcc ttgcacttaa ttcaggagtc
     4381 gcttgaattc attgacaagc agttggcagc ttatatcact gacaaggtgg atgcagctca
     4441 aatgcctcag gaagcccaga aaatccaatc agatttgaca agtcatgaga taagtttaga
     4501 agaaatgaag aaacataacc aggggaagga tgccaaccaa agggttcttt cacaaattga
     4561 tgttgcacag aaaaaattac aagatgtctc catgaaattt cgattattcc aaaaaccagc
     4621 caattttgaa caacgtctag aggaaagtaa gatgatttta gatgaagtca agatgcattt
     4681 gcctgcattg gaaaccaaga gtgttgaaca ggaagtaatt cagtcacaac taagtcattg
     4741 tgtgaacttg tataaaagcc tgagtgaagt caagtctgaa gtggaaatgg tgattaaaac
     4801 cggacgtcaa attgtacaga aaaagcagac agaaaatccc aaagagcttg atgaacgagt
     4861 aacagctttg aaattgcatt acaatgagtt gggtgcgaag gtaacagaga gaaagcaaca
     4921 gttggagaaa tgcttgaagt tgtcccgtaa gatgagaaag gaaatgaatg tcttaacaga
     4981 atggctggca gcaacagata cagaattgac gaagagatca gcagttgaag gaatgccaag
     5041 taatttggat tctgaagttg cctggggaaa ggctactcaa aaagagattg agaaacagaa
     5101 ggctcacttg aagagtgtta cagaattagg agagtctttg aaaatggtgt tgggcaagaa
     5161 agaaaccttg gtagaagata aactgagtct tctgaacagt aactggatag ctgtcacctc
     5221 cagagtagaa gaatggctaa atcttttgtt ggaataccag aaacacatgg aaacctttga
     5281 tcagaacata gaacaaatca caaagtggat cattcatgca gatgaacttt tagatgagtc
     5341 tgaaaagaag aaaccacaac aaaaggaaga cattcttaag cgtttaaagg ctgaaatgaa
     5401 tgacatgcgc ccaaaggtgg actccacacg tgaccaagca gcaaaattga tggcaaaccg
     5461 cggtgaccac tgcaggaaag tagtagagcc ccaaatctct gagctcaacc gtcgatttgc
     5521 agctatttct cacagaatta agactggaaa ggcctccatt cctttgaagg aattggagca
     5581 gtttaactca gatatacaaa aattgcttga accactggag gctgaaattc agcagggggt
     5641 gaatctgaaa gaggaagact tcaataaaga tatgagtgaa gacaatgagg gtactgtaaa
     5701 tgaattgttg caaagaggag acaacttaca acaaagaatc acagatgaga gaaagcgaga
     5761 ggaaataaag ataaaacagc agctgttaca gacaaaacat aatgctctca aggatttgag
     5821 gtctcaaaga agaaaaaagg ccctagaaat ttctcaccag tggtatcagt acaagaggca
     5881 ggctgatgat ctcctgaaat gcttggatga aattgaaaaa aaattagcca gcctacctga
     5941 acccagagat gaaagaaaat taaaggaaat tgatcgtgaa ttgcagaaga agaaagagga
     6001 gctgaatgca gtgcgcaggc aagctgaggg cttgtctgag aatggggccg caatggcagt
     6061 ggagccaact cagatccagc tcagcaagcg ctggcggcaa attgagagca attttgctca
     6121 gtttcgaaga ctcaactttg cacaaattca cactctccat gaagaaacta tggtagtgac
     6181 gactgaagat atgcctttgg atgtttctta tgtgccttct acttatttga ccgagatcag
     6241 tcatatctta caagctcttt cagaagttga tcatcttcta aatactcctg aactctgtgc
     6301 taaagatttt gaagatcttt ttaagcaaga ggagtctctt aagaatataa aagacaattt
     6361 gcaacaaatc tcaggtcgga ttgatattat tcacaagaag aagacagcag ccttgcaaag
     6421 tgccacctcc atggaaaagg tgaaagtaca ggaagccgtg gcacagatgg atttccaggg
     6481 ggaaaaactt catagaatgt acaaggaacg acaagggcga ttcgacagat cagttgaaaa
     6541 atggcgacac tttcattatg atatgaaggt atttaatcaa tggctgaatg aagttgaaca
     6601 gtttttcaaa aagacacaaa atcctgaaaa ctgggaacat gctaaataca aatggtatct
     6661 taaggaactc caggatggca ttgggcagcg tcaagctgtt gtcagaacac tgaatgcaac
     6721 tggggaagaa ataattcaac agtcttcaaa aacagatgtc aatattctac aagaaaaatt
     6781 aggaagcttg agtctgcggt ggcacgacat ctgcaaagag ctggcagaaa ggagaaagag
     6841 gattgaagaa caaaagaatg tcttgtcaga atttcaaaga gatttaaatg aatttgtttt
     6901 gtggctggaa gaagcagata acattgctat tactccactt ggagatgagc agcagctaaa
     6961 agaacaactt gaacaagtca agttactggc agaagagttg cccctgcgcc agggaattct
     7021 aaaacaatta aatgaaacag gaggagcagt acttgtaagt gctcccataa ggccagaaga
     7081 gcaagataaa cttgaaaaga agctcaaaca gacaaatctc cagtggataa aggtctccag
     7141 agctttacct gagaaacaag gagagcttga ggttcactta aaagatttta ggcagcttga
     7201 agagcagctg gatcacctgc ttctgtgggt ctctcctatt agaaaccagt tggaaattta
     7261 taaccaacca agtcaggcag gaccgtttga cataaaggag attgaagtaa cagttcacgg
     7321 taaacaagcg gatgtggaaa ggcttttgtc gaaagggcag catttgtata aggaaaaacc
     7381 aagcactcag ccagtgaaga ggaagttaga agatctgagg tctgagtggg aggctgtaaa
     7441 ccatttactt cgggagctga ggacaaagca gcctgaccgt gcccctggac tgagcactac
     7501 tggagcctct gccagtcaga ctgttactct agtgacacaa tctgtggtta ctaaggaaac
     7561 tgtcatctcc aaactagaaa tgccatcttc tttgctgttg gaggtacctg cactggcaga
     7621 cttcaaccga gcttggacag aacttacaga ctggctgtct ctgcttgatc gagttataaa
     7681 atcacagaga gtgatggtgg gtgatctgga agacatcaat gaaatgatca tcaaacagaa
     7741 ggcaacactg caagatttgg aacagagacg cccccaattg gaagaactca ttactgctgc
     7801 ccagaatttg aaaaacaaaa ccagcaatca agaagctaga acaatcatta ctgatcgaat
     7861 tgaaagaatt cagattcagt gggatgaggt tcaagaacag ctgcagaaca ggagacaaca
     7921 gttgaatgaa atgttaaagg attcaacaca atggctggaa gctaaggaag aagccgaaca
     7981 ggtcatagga caggtcagag gcaagcttga ctcatggaaa gaaggtcctc acacagtaga
     8041 tgcaatccaa aagaagatca cagaaaccaa gcagttggcc aaagacctcc gtcaacggca
     8101 gataagtgta gacgtggcaa atgatttggc actgaaactt cttcgggact attctgctga
     8161 tgataccaga aaagtacaca tgataacaga gaatatcaat acttcttggg gaaacattca
     8221 taaaagagta agtgagcaag aggctgcttt ggaagaaact catagattac tgcagcagtt
     8281 ccctctggac ctggagaagt ttctttcctg gattacggaa gcagaaacaa ctgccaatgt
     8341 cctacaggac gcttcccgta aggagaagct cctagaagac tccaggggag tcagagagct
     8401 gatgaaacca tggcaagatc tccaaggaga aattgaaact cacacagata tctatcacaa
     8461 tcttgatgaa aatggccaaa aaatcctgag atccctggaa ggttcggatg aagcacccct
     8521 gttacaaaga cgtttggata acatgaattt caagtggagt gaacttcaga aaaagtctct
     8581 caacattagg tcccatttgg aagcaagttc tgaccagtgg aagcgtttgc atctttctct
     8641 tcaggaactt cttgtttggc tacagctgaa agatgatgaa ctgagccgtc aggcacccat
     8701 cggtggtgat ttcccagcag ttcagaagca gaatgatata catagggcct tcaagaggga
     8761 attgaaaact aaagaacctg taatcatgag tactctggag actgtgagaa tatttctgac
     8821 agagcagcct ttggaaggac tagagaaact ctaccaggag cccagagaac tgcctcctga
     8881 agaaagagct cagaatgtca ctcggctcct acgaaagcag gctgaagagg tcaacgctga
     8941 atgggacaaa ttgaacctgc gctcagctga ttggcagaga aaaatagatg aagctcttga
     9001 aagactccag gaacttcagg aagctgccga tgaactggac ctcaagttgc gccaagctga
     9061 ggtgatcaag ggatcctggc agccagtggg ggatctcctc attgactctc tgcaagatca
     9121 ccttgaaaaa gtcaaggcac ttcggggaga aattgcacct cttaaagaga atgtcaatcg
     9181 tgtcaatgac cttgcacatc agctgaccac actgggcatt cagctctcac cttataacct
     9241 cagcactttg gaagatctga ataccagatg gaggcttcta caggtggctg tggaggaccg
     9301 tgtcagacag ctgcatgaag cccacaggga ctttggtcct gcatcccagc acttcctttc
     9361 cacttcagtt cagggtccct gggagagagc catctcacca aacaaagtgc cctactatat
     9421 caaccacgag acccaaacca cttgttggga ccaccccaaa atgacagagc tctaccagtc
     9481 tttagctgac ctgaataatg tcaggttctc cgcgtatagg actgccatga agctcagaag
     9541 gctccagaag gccctttgct tggatctctt gagcctgtca gctgcatgtg atgccctgga
     9601 ccagcacaac ctcaagcaaa atgaccagcc catggatatc ctgcagataa ttaactgttt
     9661 gactacaatt tatgatcgtc tggagcaaga gcacaacaat ctggtcaatg tccctctctg
     9721 tgtggatatg tgtctcaact ggcttctcaa tgtttatgat acgggacgaa cagggaggat
     9781 ccgtgtcctg tcttttaaaa ctggcatcat ttctctgtgt aaagcacact tggaagacaa
     9841 gtacagatac cttttcaagc aagtggcaag ttcaactggc ttttgtgacc agcgtaggct
     9901 gggtcttctt ctgcatgatt ctattcaaat cccaagacag ttgggtgaag ttgcttcctt
     9961 tgggggcagt aacattgagc cgagtgtcag gagctgcttc caatttgcca ataataaacc
    10021 tgagattgaa gctgctctct tccttgactg gatgcgcctg gaaccccagt ctatggtgtg
    10081 gctgcccgtc ttgcacagag tggctgctgc tgaaactgcc aagcatcaag ccaagtgtaa
    10141 catctgtaag gagtgtccaa tcattggatt caggtacaga agcctaaagc attttaatta
    10201 tgacatctgc caaagttgct ttttttctgg ccgagttgca aagggccata aaatgcacta
    10261 ccccatggta gagtattgca ctccgactac atccggagaa gatgttcgcg acttcgccaa
    10321 ggtactaaaa aacaaatttc gaaccaaaag gtattttgcg aagcatcccc gaatgggcta
    10381 cctgccagtg cagactgtgt tagaggggga caacatggaa actcccgtta ctctgatcaa
    10441 cttctggcca gtagattctg cgcctgcctc gtccccccag ctttcacacg atgatactca
    10501 ttcacgcatt gaacattatg ctagcaggct agcagaaatg gaaaacagca atggatctta
    10561 tctaaatgat agcatctctc ctaatgagag catagatgat gaacatttgt taatccagca
    10621 ttactgccaa agtttgaacc aggactcccc cctgagccag cctcgtagtc ctgcccagat
    10681 cttgatttcc ttagagagtg aggaaagagg ggagctagag agaatcctag cagatcttga
    10741 ggaagaaaac aggaatctgc aagcagaata tgatcgcctg aagcagcagc atgagcataa
    10801 aggcctgtct ccactgccat ctcctcctga gatgatgccc acctctcctc agagtcccag
    10861 ggatgctgag ctcattgctg aggctaagct actgcgccaa cacaaaggac gcctggaagc
    10921 caggatgcaa atcctggaag accacaataa acagctggag tctcagttac atagactgag
    10981 acagctcctg gagcagcccc aggctgaagc taaggtgaat ggcaccacgg tgtcctctcc
    11041 ttccacctct ctgcagaggt cagatagcag tcagcctatg ctgctccgag tggttggcag
    11101 tcaaacttca gaatctatgg gtgaggaaga tcttctgagt cctccccagg acacaagcac
    11161 agggttagaa gaagtgatgg agcaactcaa caactccttc cctagttcaa gaggaagaaa
    11221 tgcccccgga aagccaatga gagaggacac aatgtaggaa gccttttcca catggcagat
    11281 gatttgggca gagcgatgga gtccttagtt tcagtcatga cagatgaaga aggagcagaa
    11341 taaatgtttt acaactcctg attcccgcat ggtttttata atattcgtac aacaaagagg
    11401 attagacagt aagagtttac aagaaataaa atctatattt ttgtgaaggg tagtggtact
    11461 atactgtaga tttcagtagt ttctaagtct gttattgttt tgttaacaat ggcaggtttt
    11521 acacgtctat gcaattgtac aaaaaagtta aaagaaaaca tgtaaaatct tgatagctaa
    11581 ataacttgcc atttctttat atggaacgca ttttgggttg tttaaaaatt tataacagtt
    11641 ataaagagag attgtaaact aaagtgtgct ttataaaaaa agttgtttat aaaaacccct
    11701 aaacaaacac acacgcacac acacacacac acacacacac acacacacac gcacacatac
    11761 atgcacgaac ccaccacaca cacacacaca cacacacaca ctgaggcagc acattgtttt
    11821 gcattacttt agcgtggtat tcatatggaa ttcatgacgt ttttttattt tcttgcatac
    11881 gaaccccacc aaatgactgc ttcatattgc tcttttgaga attgttgact gagtggggct
    11941 ggctatgggc tttcatttta tacatctata tgtctacaag tatataaata ctataggtat
    12001 atagataaat agatatgaag ttacttcttc aaatgttctt gccacttcct aatggaaatt
    12061 gcttctagtc atctgggctt atctgcttgg gcaagagtga attttccctg gagcccaaag
    12121 ccaggagact accgccacac taaaatattg tctagggctc cagatgtttc tagttttaaa
    12181 ctttccactg agagctagag gattcatttt tttcaaggaa catgcgaatg aatacacagg
    12241 acttactatc atagtaattt gttggctgat atattcaact tcctactgtt gggttatatt
    12301 taatgatgtt tctgcaatag aacatcagat gacattttta actcccagac agtaggagga
    12361 agatggtagg agctaaaggt tgcggctcct cagtcaattt atatgagggg agcaacaact
    12421 ctgtaaaaga atggatgaat atttacaact atacatataa acatctctat aattacaact
    12481 aaattgttct gccctcttca taaactcaac ctgaagtggg tggttttgtt gttgttgttg
    12541 ttgttgttgt tgatgatgat gatgaatttt agattttaga ttttttgggt ttttttttct
    12601 tcattgtgat gatttttttt tttaatgctg caagacttag gattactgtt aagaaagtaa
    12661 cccaatcaca ttgtgaccct ggtgaatatc agtccagaag cccatgaact gcatttgtct
    12721 cctttgcatt ggtttccctg caagtaactc cacacaggat tgtgggtgag aaggcacagt
    12781 ggttggaaag ttttgagagc aaaagcgtct ccaaactctc tggtctagtt gacgggctga
    12841 aatgtctaaa caaatgcaag tcattgaacc aggagaaaaa gtgcaacaga aagctaagga
    12901 ctgctaggaa gagctttact cctctcatgc cagtttcttc ttcttagcat ttaaagagca
    12961 ttctctcaat agaaatcact gtcctatcat tttgcaaatc tgttacctct aacgtcaagt
    13021 gtaattaact tctagcgagt gggttttgtc cattattaat tgtaattaac atcaaacaca
    13081 gcttctcatg ctatttctac ctcactttgg ttttggggtg tttctagtaa ttgtgcacac
    13141 ctaatttcac aacttcacca cttgtctgtt gtgtggacac cagtttcctt ttttcattta
    13201 taatttccaa aagaaaaccc aaagctctaa gataacaaat tgaaatttgg ttctggtctt
    13261 gcttttctct ctctctctcc tttatgtggc actgggcatt ttctttatcc aaggatttgt
    13321 tttcaccaag atttaaaaca aggggttcct ttcctactaa gaagttttaa gtttcattct
    13381 aaaatccaag gtagatagag tgcatagttt tgttttaatc ttttcgtttt atcttttaga
    13441 tattagttct ggagtgaatc tatcaaaata tttgaataaa aactgagagc tttattgctg
    13501 attttaagca taatttggac atcatttcat gttctttata accatcaagt attaaagtgt
    13561 aaatcataat cagtgtaact gaagcataat catcacatgg catgtatcat cattgtctcc
    13621 aggtactgga ctcttacttg agtatcataa tagattgtgt tttaacacca acactgtaac
    13681 atttactaat tattttttta aacttcagtt ttactgcatt ttcacaacat atcagatttc
    13741 accaaatata tgccttacta ttgtattata ttactgcttt actgtgtatc tcaataaagc
    13801 acgcagttat gttac
//