From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: C.elegans let-23 mRNA for tyrosine kinase
Date: 25 Jul 92 10:02:55 GMT
Distribution: bionet
Checksum: 20810     9

LOCUS       CELLET23     4320 bp ss-RNA             INV       25-JUL-1992
DEFINITION  C.elegans let-23 mRNA for tyrosine kinase
ACCESSION   X57767
KEYWORDS    Tyrosine kinase; let-23 gene.
SOURCE      Caenorhabditis elegans RNA.
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Animalia; Eumetazoa; Nematoda; Secernentea; Rhabditida;
            Rhabditina; Rhabditoidea; Rhabditidae.
REFERENCE   1  (bases 1 to 4320)
  AUTHORS   Aroian,R.V., Koga,M., Mendel,J.E., Ohshima,Y. and Sternberg,P.W.
  TITLE     The let-23 gene necessary for Caenorhabditis elegans vulval
            induction encodes a tyrosine kinase of the EGF receptor subfamily
            [see comments]
  JOURNAL   Nature 348, 693-699 (1990)
  STANDARD  full automatic
COMMENT     From EMBL    entry CELET23;  dated 25-JUN-1992.
FEATURES             Location/Qualifiers
     CDS             79..4050
                     /product="tyrosine kinase"
                     /gene="let-23"
                     /codon_start=1
                     /translation="MRYPPSIGSILLIIPIFLTFFGNSNAQLWKRCVSPQDCLCSGTT
                     NGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSP
                     LKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDNALYIHKNDKVHEVV
                     MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMA
                     KCHESCNDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGP
                     KNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIEN
                     DVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHL
                     IIEHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKNLQIIEGRKLHNVRWALAIY
                     QCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENR
                     DSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQTSMK
                     CERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCH
                     PTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYIST
                     YDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSF
                     MVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPFS
                     NPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMV
                     DMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKI
                     PVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQ
                     NFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFG
                     LSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPY
                     QGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCK
                     VPQLFLENSNKISESDLSAEERFQTERIREMFHGNIDPQMYFDQGSLPSMPSSPTSMA
                     TFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTN
                     EDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSEEAEAVQYENEEVSQKE
                     TCL"
BASE COUNT     1462 a    770 c    856 g   1232 t
ORIGIN
        1 agaaaagtgg tcatagaaga gtgaaaaaaa ggaagaattt gtccaagttt tctcactatc
       61 tacaattttc tgggaggcat gcgataccct ccctctatcg gttcaatttt attgattatt
      121 cctatttttc taacattttt tggaaattct aatgcacagt tgtggaaaag atgtgtttca
      181 cctcaagact gcctttgttc tggcacaacc aatggaatat cgagatatgg aaccggaaat
      241 attttggaag atctggaaac tatgtaccga gggtgtcgtc gtgtttatgg aaatcttgaa
      301 ataacatgga tagaagcaaa tgaaataaag aaatggagag aatcgacgaa tagcactgtg
      361 gacccaaaaa atgaagattc accattgaaa tcaattaact tttttgataa tttagaggag
      421 attcgaggaa gcttaataat ttatcgtgcg aatattcaaa aaatatcatt tccaagacta
      481 cgagtaatct acggagacga ggtttttcac gataatgcat tgtacattca taaaaatgat
      541 aaagttcacg aagttgtgat gagagagttg agagtgatta ggaatggaag tgtcacaatt
      601 caagacaatc caaaaatgtg ttacattggg gataaaatcg attggaagga gttactgtac
      661 gacccagatg tacagaaagt tgaaactaca aactcacatc aacattgcta tcaaaatgga
      721 aaatcaatgg caaaatgcca tgaaagttgt aatgataaat gttggggatc cggagacaat
      781 gattgtcaac gagtctaccg ttccgtatgt ccaaaatctt gttctcagtg tttctactcg
      841 aactctacaa gttcatacga atgttgtgac tcggcttgtc ttggaggatg tacaggtcac
      901 ggaccaaaaa attgcattgc ctgcagtaaa tatgaattgg atggaatctg tatcgaaacg
      961 tgcccatcgc gaaaaatttt caatcacaaa acaggacgat tagtttttaa cccagacgga
     1021 agataccaaa atggaaatca ttgtgtgaaa gaatgccctc ctgaacttct aatcgaaaac
     1081 gatgtatgtg ttcgtcactg ctcagatggt caccattatg atgctacaaa agatgttaga
     1141 gagtgtgaaa aatgcagaag ttccagctgt ccaaaaattt gcacggtcga tggacatctg
     1201 acaaacgaga cacttaaaaa cttggaaggc tgcgaacaaa ttgatggtca tttgataata
     1261 gagcatgcat tcacatacga acaactaaaa gtcttggaga cagtgaaaat tgttagcgag
     1321 tacatcacga ttgttcagca aaacttctat gacttaaagt ttctcaaaaa tctacaaatc
     1381 attgaaggcc gaaaacttca caatgtaaga tgggctctcg caatttatca atgcgatgac
     1441 ttggaagaac tgagcttaaa ctcattgaaa cttataaaaa ctggagctgt attaataatg
     1501 aaaaatcatc gattgtgtta tgtgtcgaaa attgattggt catcaattat cacttcaaag
     1561 ggaaaagata acaaaccctc attggcaatt gctgaaaata gggatagcaa actgtgtgaa
     1621 actgaacaga gagtttgtga taaaaactgc aataaacgtg gttgttgggg caaggaacca
     1681 gaggactgtc tcgagtgtaa gacctggaaa agtgttggga cgtgtgttga gaaatgtgac
     1741 acgaaaggat ttctgcgcaa ccagacatca atgaaatgcg aaagatgttc tccggaatgt
     1801 gaaacctgca acggtctagg tgaactggat tgtctcactt gcagacataa aactctctac
     1861 aattcggatt tcggtaatcg tatggaatgt gtccacgatt gtccagtttc acactttccg
     1921 acgcagaaaa atgtatgcga aaagtgtcat ccgacgtgtt atgataatgg atgtactgga
     1981 cctgactcaa acctaggcta tggaggatgt aagcagtgca aatacgctgt aaaatatgaa
     2041 aatgatacaa tattctgctt acaatcatct ggaatgaaca atgtgtgtgt ggaaaatgac
     2101 ttgcctaact attacatttc aacatatgat accgaaggag tcattgagac tcactgcgaa
     2161 aaatgttcaa tttcctgcaa aacatgtagt tcagctggtc gcaatgttgt tcagaacaag
     2221 tgtgtttgca agcatgttga atatcaacct aatccttcgg aaagaatttg tatggatcag
     2281 tgtccagtga acagttttat ggttcccgac acaaataaca cggtctgtaa aaaatgtcat
     2341 catgaatgtg atcagaacta tcattgtgca aatggtcaat caactggatg ccaaaaatgt
     2401 aaaaacttta cggttttcaa gggagatatt gctcaatgcg tcagcgaatg cccaaagaat
     2461 cttccatttt cgaatccggc aaatggagaa tgtttggact acgatattgc atcaagacag
     2521 cgaaaaacaa gaatggttat tattggaagc gtgttatttg gatttgcagt gatgttcttg
     2581 ttcattttgc tcgtctactg gagatgtcaa cgtattggta aaaaactgaa aatcgctgaa
     2641 atggttgaca tgcctgaact aactccaatt gatgccagtg ttcgaccaaa catgtctaga
     2701 atttgcctca ttccatcatc cgagctgcaa accaaactag acaaaaagct gggagccgga
     2761 gcattcggaa ctgtctttgc tggaatttac tatccaaagc gagcaaagaa tgttaaaatc
     2821 ccggttgcaa tcaaagtatt ccaaacagat caaagtcaaa ctgatgaaat gttggaagaa
     2881 gctacgaata tgttcagatt gagacacgat aatttgctca agattattgg attctgtatg
     2941 cacgatgatg gtttgaaaat tgtcactatc tacagacctc tcggaaatct tcaaaacttt
     3001 ttgaaacttc acaaggaaaa tttgggtgca cgagaacaag tattatattg ttatcaaatt
     3061 gcatctggaa tgcaatattt agagaaacag cgagttgttc acagagattt ggcaacaaga
     3121 aatgttcttg tgaagaagtt caatcacgtg gaaatcactg attttggtct ctctaaaatt
     3181 ctgaaacatg acgccgactc aatcactatc aaatctggaa aagttgcaat caaatggctt
     3241 gcgatcgaaa tcttctccaa acattgttac acccatgctt ctgatgtttg ggcatttgga
     3301 gtcacatgtt gggagattat aacatttgga caaagtccgt atcaaggaat gtcgactgat
     3361 agtattcata atttcttgaa agatggaaac cgtctttccc agccaccaaa ctgctctcaa
     3421 gacttgtatc aagagcttct gagatgttgg atggcggatc caaagtctcg tcctggtttt
     3481 gaaatattat atgaaagatt taaagaattc tgtaaggttc cccaactttt cctggaaaat
     3541 tccaacaaga tttctgaatc tgatttgtca gctgaagaac gttttcaaac ggaaagaatc
     3601 cgagaaatgt ttcatggaaa tatcgatcca cagatgtact ttgatcaagg aagtttacca
     3661 agtatgccaa gttctccaac ttctatggca acgttcacaa ttccacatgg tgatctgatg
     3721 aatcgaatgc aatcagtaaa ctcatctagg tacaaaacgg agccttttga ttatgggtca
     3781 accgcacagg aagataattc atatcttatt ccaaaaacca aagaagttca gcagtcagca
     3841 gttttgtata cagctgttac aaatgaagat ggtcaaaccg agctatcccc atcaaatggc
     3901 gattactaca accaaccaaa cactccttca tcttcctctg gatattacaa tgaaccacat
     3961 ctcaaaacta aaaaacctga aacatcagaa gaggctgaag cagttcaata tgaaaatgaa
     4021 gaagtatcac aaaaggaaac ttgtctttaa cttttcgaac atcccatttc agaacatttt
     4081 ttgtcattcc cgttgccatt catctcatac aatttgccat catgcataat tagaattatt
     4141 taatcaaaaa tctcattttc tttgtatttt ttaatgttgt tggatgattc attcacaaaa
     4201 ttcccaaaaa tttcgagctt tattctgaaa acattatcca tattccacaa tgcatttttt
     4261 catcgggtct tcgttgtctt gtacagctaa aaataaataa ataaatcttt gttgctctcc
//