From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: R.norvegicus CYP3A2 gene for cytochrome P450 PCN2
Date: 4 Sep 92 10:06:30 GMT
Distribution: bionet
Checksum: 37496     4

LOCUS       RATCYP3A2    1572 bp ds-DNA             ROD       04-SEP-1992
DEFINITION  R.norvegicus CYP3A2 gene for cytochrome P450 PCN2
ACCESSION   X62087
KEYWORDS    CYP3A2 gene; Cytochrome P450 PCN2; NADP dependent cytochrome P450;
            dexamethosone-induced cytochrome P450; monoxygenase;
            phenobarbital-induced cytochrome P-450.
SOURCE      Rattus norvegicus DNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Telhada,M.B., Pereira,T.M. and Lechner,M.C.
  TITLE     Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
  JOURNAL   Arch. Biochem. Biophys. (1992) In press
  STANDARD  full automatic
COMMENT     *source: strain=Wistar; *source: stage=adult; *source: tissue=
            liver; *source: clone_library=genomic: EMBL3cosW; *source: clone=
            pBluescript II SK +/- CYP3A2;
            For related sequences see X62086, M10161, Gonzalez F.J.; Mol.Cell
            Biol. 6:2969-2976(1986), Yanagida A.; Mol.Cell Biol. 10:
            1470-1475(1990), Miyata; Biochem.Biophys.Res.Comm. 177:68-73(1991)
            & Herbomel; Specific Gene Expression (Reukawitz ed.) VCH Weinneim:
            165-184(1989)
            From EMBL    entry RNCYP3A2;  dated 10-AUG-1992.
FEATURES             Location/Qualifiers
     mRNA            join(1003..1164,1535..>1557)
                     /note="products EC number is1.14.14.1"
                     /gene="CYP3A2"
                     /partial
     misc_feature    300..315
                     /note="HNF-1"
     TATA_signal     974..978
     exon            1003..1164
                     /number=1
     intron          1165..1534
                     /number=1
     exon            1535..>1572
                     /number=2
BASE COUNT      352 a    361 c    341 g    518 t
ORIGIN
        1 gtccagctcc tgcatgctct ttggttggtg attcattcta tatgagacca atggtaccag
       61 gttagttggt tctctagatc ttcttgtggt atccttgacc cctcagactc actgaatcct
      121 gtactccact cttccacagg actctttgtt cttcctctga tgctttacta tggctctctg
      181 catttcaata gctatttttt ttattaaata actttatctc tctccccatc tctctgtctc
      241 tgtctatctg tccgtgtctt tctctgtgcg tgagacaact ttatgtatag aaagcattct
      301 ggttaattct cccccttctc ttatcccatc cctgtcaccc tcagttcttc cctacaaagc
      361 tcctatccat attcataact tgttttgtgt cctgaacact tcatctagtt tcctgtgtgt
      421 gtgagactgc aggtttggaa ctgtccatta aagcctgtgg gtcaccagcc atcagtgagt
      481 tcacaactga gtacggtttc tctctctcag cagtgagtgt caggactagt gtctctttct
      541 ctctggcacc atagtcaagg gatggcaggt gttgaatttt ggtggataga tgtagtagat
      601 tgttttttga ggcacgtttt cccatatccc aggctggtct caaacattct atgtggcttt
      661 gaacttgtct ttgaatttct gatccccctg cttctattct ctgagtgtat tttgatgaag
      721 ccagcagtgg tgagagggta ggtatttcat gttattgaat ttgcctaaat ttctgaaaga
      781 aatcaagaac ttttactctt acccatgtag cactgctgtt tactgatgcc acacagaatg
      841 ttagctcaag aaggtcaaag aagctgtaga tgaactttat gaactgctta gggcaagaga
      901 gtaccaaagt ccaggtgagc cagaggtgat ccatctactg gttggatccc tggtgccacc
      961 catctttcca gcatataagt actgcaggct ggcctcagtg cagctgtgtg gtcaggaggg
     1021 aagacctgca gagtatcaga ggcccagcta gagggagaac accgaggagt aatttgctga
     1081 cagacaagca gggatggacc tgctttcagc tctcacactg gaaacctggg tcctcctggc
     1141 agtcatcctg gtgcttctct accggtgagt gacctcggaa gttcctcctt gtgaccaggt
     1201 tcttgggttt gaagtgatac ttagacctat attctgttat tattgggagg atcaaaatga
     1261 tatcagaatc aggctagaga gatggttgtt cctttcttca gggcactggc tgctctttca
     1321 gagggcccag atttgaaccc aaacatccac atgcagctca cagtcatctg taactacagc
     1381 taaagtttat ctgacacctt ccattcccaa agctgtgtgg aaactggagg ggcagcctaa
     1441 ttgttggttt gtttcagttt ttaatgatgg tcttgcttgt ctcctttctc tattctgtgt
     1501 gtatggccac acttctttct gttttccttt atagacttgg aacccataga catggaattt
     1561 ttaagaaaca ag
//