From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Haemophilus influenzae adhesin (hmw2) gene, complete cds.
Date: 10 Apr 92 10:05:22 GMT
Distribution: bionet
Checksum: 18596    10

LOCUS       HEAHMW2AD    4937 bp ds-DNA             BCT       10-APR-1992
DEFINITION  Haemophilus influenzae adhesin (hmw2) gene, complete cds.
ACCESSION   M84615
KEYWORDS    adhesin; hmw2 gene; surface-associated protein.
SOURCE      Haemophilus influenzae (strain 12) (library: lambda EMBL3) DNA.
  ORGANISM  Haemophilus influenzae
            Prokaryota; Bacteria; Gracilicutes; Scotobacteria;
            Facultatively anaerobic rods; Pasteurellaceae.
REFERENCE   1  (bases 1 to 4937)
  AUTHORS   Leininger,E. and Barenkamp,S.J.
  TITLE     Cloning, expression, and DNA sequence analysis of genes encoding
            nontypable Haemophilus influenzae high molecular weight surface
            exposed proteins related to filamentous hemagglutinin of Bordetella
            pertussis
  JOURNAL   Infect. Immun. 60, 1303-1312 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     repeat_region   129..240
                     /rpt_type=direct tandem repeats
                     /gene="hmw2"
     CDS             352..4785
                     /product="adhesin"
                     /gene="hmw2"
                     /codon_start=1
                     /translation="MNKIYRLKFSKRLNALVAVSELARGCDHSTEKGSEKPARMKVRH
                     LALKPLSAMLLSLGVTSIPQSVLASGLQGMDVVHGTATMQVDGNKTIIRNSVDAIINW
                     KQFNIDQNEMVQFLQENNNSAVFNRVTSNQISQLKGILDSNGQVFLINPNGITIGKDA
                     IINTNGFTASTLDISNENIKARNFTFEQTKDKALAEIVNHGLITVGKDGSVNLIGGKV
                     KNEGVISVNGGSISLLAGQKITISDIINPTITYSIAAPENEAVNLGDIFAKGGNINVR
                     AATIRNQGKLSADSVSKDKSGNIVLSAKEGEAEIGGVISAQNQQAKGGKLMITGDKVT
                     LKTGAVIDLSGKEGGETYLGGDERGEGKNGIQLAKKTSLEKGSTINVSGKEKGGRAIV
                     WGDIALIDGNINAQGSGDIAKTGGFVETSGHYLSIDSNAIVKTKEWLLDPDDVTIEAE
                     DPLRNNTGINDEFPTGTGEASDPKKNSELKTTLTNTTISNYLKNAWTMNITASRKLTV
                     NSSINIGSNSHLILHSKGQRGGGVQIDGDITSKGGNLTIYSGGWVDVHKNITLDQGFL
                     NITAASVAFEGGNNKARDAANAKIVAQGTVTITGEGKDFRANNVSLNGTGKGLNIISS
                     VNNLTHNLSGTINISGNITINQTTRKNTSYWQTSHDSHWNVSALNLETGANFTFIKYI
                     SSNSKGLTTQYRSSAGVNFNGVNGNMSFNLKEGAKVNFKLKPNENMNTSKPLPIRFLA
                     NITATGGGSVFFDIYANHSGRGAELKMSEINISNGANFTLNSHVRGDDAFKINKDLTI
                     NATNSNFSLRQTKDDFYDGYARNAINSTYNISILGGNVTLGGQNSSSSITGNITIEKA
                     ANVTLEANNAPNQQNIRDRVIKLGSLLVNGSLSLTGENADIKGNLTISESATFKGKTR
                     DTLNITGNFTNNGTAEINITQGVVKLGNVTNDGDLNITTHAKRNQRSIIGGDIINKKG
                     SLNITDSNNDAEIQIGGNISQKEGNLTISSDKINITKQITIKKGIDGEDSSSDATSNA
                     NLTIKTKELKLTEDLSISGFNKAEITAKDGRDLTIGNSNDGNSGAEAKTVTFNNVKDS
                     KISADGHNVTLNSKVKTSSSNGGRESNSDNDTGLTITAKNVEVNKDITSLKTVNITAS
                     EKVTTTAGSTINATNGKASITTKTGDISGTISGNTVSVSATGDLTTKSGSKIEAKSGE
                     ANVTSATGTIGGTISGNTVNVTANAGDLTVGNGAEINATEGAATLTATGNTLTTEAGS
                     SITSTKGQVDLLAQNGSIAGSINAANVTLNTTGTLTTVAGSDIKATSGTLVINAKDAK
                     LNGDASGDSTEVNAVNASGSGSVTAATSSSVNITGDLNTVNGLNIISKDGRNTVRLRG
                     KEIEVKYIQPGVASVEEVIEAKRVLEKVKDLSDEERETLAKLGVSAVRFVEPNNTITV
                     NTQNEFTTRPSSQVIISEGKACFSSGNGARVCTNVADDGQP"
BASE COUNT     1732 a    950 c   1012 g   1243 t
ORIGIN
        1 taaatataca agataataaa aataaatcaa gatttttgtg atgacaaaca acaattacaa
       61 cacctttttt gcagtctata tgcaaatatt ttaaaaaaat agtataaatc cgccatataa
      121 aatggtataa tctttcatct ttcatctttc atctttcatc tttcatcttt catctttcat
      181 ctttcatctt tcatctttca tctttcatct ttcatctttc atctttcatc tttcatcttt
      241 cacatgaaat gatgaaccga gggaagggag ggaggggcaa gaatgaagag ggagctgaac
      301 gaacgcaaat gataaagtaa tttaattgtt caactaacct taggagaaaa tatgaacaag
      361 atatatcgtc tcaaattcag caaacgcctg aatgctttgg ttgctgtgtc tgaattggca
      421 cggggttgtg accattccac agaaaaaggc agcgaaaaac ctgctcgcat gaaagtgcgt
      481 cacttagcgt taaagccact ttccgctatg ttactatctt taggtgtaac atctattcca
      541 caatctgttt tagcaagcgg cttacaagga atggatgtag tacacggcac agccactatg
      601 caagtagatg gtaataaaac cattatccgc aacagtgttg acgctatcat taattggaaa
      661 caatttaaca tcgaccaaaa tgaaatggtg cagtttttac aagaaaacaa caactccgcc
      721 gtattcaacc gtgttacatc taaccaaatc tcccaattaa aagggatttt agattctaac
      781 ggacaagtct ttttaatcaa cccaaatggt atcacaatag gtaaagacgc aattattaac
      841 actaatggct ttacggcttc tacgctagac atttctaacg aaaacatcaa ggcgcgtaat
      901 ttcaccttcg agcaaaccaa agataaagcg ctcgctgaaa ttgtgaatca cggtttaatt
      961 actgtcggta aagacggcag tgtaaatctt attggtggca aagtgaaaaa cgagggtgtg
     1021 attagcgtaa atggtggcag catttcttta ctcgcagggc aaaaaatcac catcagcgat
     1081 ataataaacc caaccattac ttacagcatt gccgcgcctg aaaatgaagc ggtcaatctg
     1141 ggcgatattt ttgccaaagg cggtaacatt aatgtccgtg ctgccactat tcgaaaccaa
     1201 ggtaaacttt ctgctgattc tgtaagcaaa gataaaagcg gcaatattgt tctttccgcc
     1261 aaagagggtg aagcggaaat tggcggtgta atttccgctc aaaatcagca agctaaaggc
     1321 ggcaagctga tgattacagg cgataaagtc acattaaaaa caggtgcagt tatcgacctt
     1381 tcaggtaaag aagggggaga aacttacctt ggcggtgacg agcgcggcga aggtaaaaac
     1441 ggcattcaat tagcaaagaa aacctcttta gaaaaaggct caaccatcaa tgtatcaggc
     1501 aaagaaaaag gcggacgcgc tattgtgtgg ggcgatattg cgttaattga cggcaatatt
     1561 aacgctcaag gtagtggtga tatcgctaaa accggtggtt ttgtggagac atcggggcat
     1621 tatttatcca ttgacagcaa tgcaattgtt aaaacaaaag agtggttgct agaccctgat
     1681 gatgtaacaa ttgaagccga agaccccctt cgcaataata ccggtataaa tgatgaattc
     1741 ccaacaggca ccggtgaagc aagcgaccct aaaaaaaata gcgaactcaa aacaacgcta
     1801 accaatacaa ctatttcaaa ttatctgaaa aacgcctgga caatgaatat aacggcatca
     1861 agaaaactta ccgttaatag ctcaatcaac atcggaagca actcccactt aattctccat
     1921 agtaaaggtc agcgtggcgg aggcgttcag attgatggag atattacttc taaaggcgga
     1981 aatttaacca tttattctgg cggatgggtt gatgttcata aaaatattac gcttgatcag
     2041 ggttttttaa atattaccgc cgcttccgta gcttttgaag gtggaaataa caaagcacgc
     2101 gacgcggcaa atgctaaaat tgtcgcccag ggcactgtaa ccattacagg agagggaaaa
     2161 gatttcaggg ctaacaacgt atctttaaac ggaacgggta aaggtctgaa tatcatttca
     2221 tcagtgaata atttaaccca caatcttagt ggcacaatta acatatctgg gaatataaca
     2281 attaaccaaa ctacgagaaa gaacacctcg tattggcaaa ccagccatga ttcgcactgg
     2341 aacgtcagtg ctcttaatct agagacaggc gcaaatttta cctttattaa atacatttca
     2401 agcaatagca aaggcttaac aacacagtat agaagctctg caggggtgaa ttttaacggc
     2461 gtaaatggca acatgtcatt caatctcaaa gaaggagcga aagttaattt caaattaaaa
     2521 ccaaacgaga acatgaacac aagcaaacct ttaccaattc ggtttttagc caatatcaca
     2581 gccactggtg ggggctctgt tttttttgat atatatgcca accattctgg cagaggggct
     2641 gagttaaaaa tgagtgaaat taatatctct aacggcgcta attttacctt aaattcccat
     2701 gttcgcggcg atgacgcttt taaaatcaac aaagacttaa ccataaatgc aaccaattca
     2761 aatttcagcc tcagacagac gaaagatgat ttttatgacg ggtacgcacg caatgccatc
     2821 aattcaacct acaacatatc cattctgggc ggtaatgtca cccttggtgg acaaaactca
     2881 agcagcagca ttacggggaa tattactatc gagaaagcag caaatgttac gctagaagcc
     2941 aataacgccc ctaatcagca aaacataagg gatagagtta taaaacttgg cagcttgctc
     3001 gttaatggga gtttaagttt aactggcgaa aatgcagata ttaaaggcaa tctcactatt
     3061 tcagaaagcg ccacttttaa aggaaagact agagataccc taaatatcac cggcaatttt
     3121 accaataatg gcactgccga aattaatata acacaaggag tggtaaaact tggcaatgtt
     3181 accaatgatg gtgatttaaa cattaccact cacgctaaac gcaaccaaag aagcatcatc
     3241 ggcggagata taatcaacaa aaaaggaagc ttaaatatta cagacagtaa taatgatgct
     3301 gaaatccaaa ttggcggcaa tatctcgcaa aaagaaggca acctcacgat ttcttccgat
     3361 aaaattaata tcaccaaaca gataacaatc aaaaagggta ttgatggaga ggactctagt
     3421 tcagatgcga caagtaatgc caacctaact attaaaacca aagaattgaa attgacagaa
     3481 gacctaagta tttcaggttt caataaagca gagattacag ccaaagatgg tagagattta
     3541 actattggca acagtaatga cggtaacagc ggtgccgaag ccaaaacagt aacttttaac
     3601 aatgttaaag attcaaaaat ctctgctgac ggtcacaatg tgacactaaa tagcaaagtg
     3661 aaaacatcta gcagcaatgg cggacgtgaa agcaatagcg acaacgatac cggcttaact
     3721 attactgcaa aaaatgtaga agtaaacaaa gatattactt ctctcaaaac agtaaatatc
     3781 accgcgtcgg aaaaggttac caccacagca ggctcgacca ttaacgcaac aaatggcaaa
     3841 gcaagtatta caaccaaaac aggtgatatc agcggtacga tttccggtaa cacggtaagt
     3901 gttagcgcga ctggtgattt aaccactaaa tccggctcaa aaattgaagc gaaatcgggt
     3961 gaggctaatg taacaagtgc aacaggtaca attggcggta caatttccgg taatacggta
     4021 aatgttacgg caaacgctgg cgatttaaca gttgggaatg gcgcagaaat taatgcgaca
     4081 gaaggagctg caaccttaac cgcaacaggg aataccttga ctactgaagc cggttctagc
     4141 atcacttcaa ctaagggtca ggtagacctc ttggctcaga atggtagcat cgcaggaagc
     4201 attaatgctg ctaatgtgac attaaatact acaggcacct taaccaccgt ggcaggctcg
     4261 gatattaaag caaccagcgg caccttggtt attaacgcaa aagatgctaa gctaaatggt
     4321 gatgcatcag gtgatagtac agaagtgaat gcagtcaacg caagcggctc tggtagtgtg
     4381 actgcggcaa cctcaagcag tgtgaatatc actggggatt taaacacagt aaatgggtta
     4441 aatatcattt cgaaagatgg tagaaacact gtgcgcttaa gaggcaagga aattgaggtg
     4501 aaatatatcc agccaggtgt agcaagtgta gaagaagtaa ttgaagcgaa acgcgtcctt
     4561 gaaaaagtaa aagatttatc tgatgaagaa agagaaacat tagctaaact tggtgtaagt
     4621 gctgtacgtt ttgttgagcc aaataataca attacagtca atacacaaaa tgaatttaca
     4681 accagaccgt caagtcaagt gataatttct gaaggtaagg cgtgtttctc aagtggtaat
     4741 ggcgcacgag tatgtaccaa tgttgctgac gatggacagc cgtagtcagt aattgacaag
     4801 gtagatttca tcctgcaatg aagtcatttt attttcgtat tatttactgt gtgggttaaa
     4861 gttcagtacg ggctttaccc atcttgtaaa aaattacgga gaatacaata aagtattttt
     4921 aacaggttat tattatg
//