From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human proteinase 3 gene, exons 2 and 3.
Date: 31 Dec 92 01:37:37 GMT
Distribution: bionet
Checksum: 51159 4

LOCUS       HUMPRT3A01   1249 bp ds-DNA             PRI       17-DEC-1992
DEFINITION  Human proteinase 3 gene, exons 2 and 3.
ACCESSION   M96838
KEYWORDS    proteinase 3.
SEGMENT     1 of 3
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Bories,D., Raynal,M.-C., Solomon,D.H., Darzynkiewicz,Z. and
            Cayre,Y.E.
  TITLE     Down-regulation of a serine protease, myeloblastin, causes growth
            arrest and differentiation of promyelocytic leukemia cells
  JOURNAL   Cell 59, 959-968 (1989)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Campanelli,D., Melchior,M., Fu,Y., Nakata,M., Shuman,H., Nathan,C.
            and Gabay,J.E.
  TITLE     Cloning of cDNA for proteinase 3: a serine protease, antibiotic,
            and autoantigen from human neutrophils
  JOURNAL   J. Exp. Med. 172, 1709-1715 (1990)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Zimmer,M., Medcalf,R.L., Fink,T.M., Mattmann,C., Lichter,P. and
            Jenne,D.E.
  TITLE     Three human elastase-like genes co-ordinately expressed in the
            myelo-monocyte lineage are organized as a single genetic locus on
            19pter
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 8215-8219 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     intron          <1..539
                     /number=1
                     /label=intron1
     exon            540..705
                     /number=2
                     /label=exon2
     intron          706..971
                     /number=2
                     /label=intron2
     exon            972..1113
                     /number=3
                     /label=exon3
     conflict        replace(1099,"")
                     /citation=[1]
                     /note="'A' in conflict"
     intron          1114..>1249
                     /number=3
                     /label=intron3
BASE COUNT      210 a    434 c    389 g    216 t
ORIGIN      
        1 aattttgttt tagagacagg gtcttgctct gttgcccagg ctggagtgca gtggtgtgat
       61 ctcagttcac tgcagccttg acctcctggg ctcaagcgat cctccctcct cagcctccca
      121 agtagctggg acgacaggtg cacaccacca tgcctggcta attttaaaat tttttgtaga
      181 gatggggtcc tcacaatttt gcccaggctg gtcttgaact cctgagctca agggagcctc
      241 ctgcctcggc ctcccaaagt gttgggatta caggcgtgag cactgcaccc agccacctgg
      301 tctgcgtctt aaaagccttc ctgactctca ggactgaaag ctgccaccag ggcgcctttg
      361 gaaatcgtcg taattataac ccccccggcc tgggcgctga gtccttccca ccagccagca
      421 ggcactgacc gggttgcaga tcgggagacg gaggctcgga gaggcccagg ggctgctctg
      481 ccatcccccc tttccctgca gcctgggggc tccctgacgc ctggactccc cccctgcagg
      541 tgctgcccga gctgcggaga tcgtgggcgg gcacgaggcg cagccacact cccggcccta
      601 catggcctcc ctgcagatgc gggggaaccc gggcagccac ttctgcggag gcaccttgat
      661 ccaccccagc ttcgtgctga cggccgcgca ctgcctgcgg gacatgtgag cggccgcctc
      721 cacacccctg tccgcccgcc ccgccctctt cctccagccc tggcccggcc gctgtccctc
      781 tgcccgggga ggacccagct aagccccgtc tgcagacccc aggccccgcg cgcgtgggca
      841 gttctggggg gaggcccggg gcagggtcgc cgagggaggg gtctggggct gcaccgcggc
      901 ctcgggaagg gccggctgtg ggcggcggcg agtgtccagg gcgccgagga gtgaccaccc
      961 cacccccgca gaccccagcg cctggtgaac gtggtgctcg gagcccacaa cgtgcggacg
     1021 caggagccca cccagcagca cttctcggtg gctcaggtgt ttctgaacaa ctacgacgcg
     1081 gagaacaaac tgaacgacgt tctcctcatc caggtgggcg ggcagggccg cgagggctcg
     1141 gaggggcacg gccagagggc tccgggaccc ccattcctgc agccagcatt cattgagcac
     1201 cactgtatcg caaccggagc acccactgta taccgggcca cgaccgagg
//