HDTenEightyP/NetNews huggingface dataset:
From: bloch@CNAM.CNAM.FR (Laurent Bloch)
Newsgroups: bionet.software
Subject: microscope image processing
Date: 4 Sep 92 10:16:18 GMT
X-Unparsable-Date: Fri, 4 Sep 92 12:16:49 MET DST


David SOURDIVE                 sourdive@pasteur.fr
Unite des Virus Oncogenes
Institut Pasteur
FRANCE

Our laboratory is presently equipped with a Zeiss Axiophot
microscope. We intend to use a slow-scan cooled CCD camera
for quantitative fluorescence microscopy. This camera will deliver arrays of
approximately 1000 x 1000 pixels x 12 to 14
bits. To acquire and process these images we intend to buy a
workstation (Silicon Graphics, Sun or even DEC)and we are thus
looking for proper acquisition board and software running on
these machines.
The application should meet these requirements
(or at least part of them) :

- deliver a good and fast video display of the image(s)
- standard operations on images (+, x, -, convoluation,
  noise reduction, linear or non linear LUTs)
- counting cells
- numbering nuclei as objects (contours, areas, ...)
- integrating the signal within these objects
- define masks and apply them to other images
- show the data in statistical format (histograms,
  correlations, ...) or export it in a format compatible with  
  standard statistics processing applications (Macintosh
  or MS/DOS Excel,Cricket Graph, or Unix based applications,..)



OPTIONALLY

- print the images to a thermal/laser printer
- drive the microscope stage (z axis, or even 3 axes)
- perform 3-D reconstruction and display from a user
  defined angle.


If you happen to know hardware/software that would meet these
recquirements or part of them, please let me know

	Please reply by e-mail to sourdive@pasteur.fr

	A summary will be done. Thanks in advance
Organization: University of Maine System
Date: Monday, 31 Aug 1992 10:55:39 EDT
From: Robert Roxby <RROXBY@MAINE.MAINE.EDU>
Newsgroups: bionet.software
Subject: gene/protein alignments for pub

If there is a DOS program that makes alignments suitable for
publication from data files, I would like to know about it.
(I know it can be done with a word processor or a spreadsheet,
but it is T-E-D-I-O-U-S.)  Thanks.
From: dbd@THEORY.BCHS.UH.EDU (Dan Davison)
Newsgroups: bionet.software
Subject: e-mail from Gene-Server down
Date: 2 Sep 92 13:08:31 GMT
Distribution: bionet

There is a problem with the queueing software on the UH Gene-Server
and the backup machine is also down.  E-mail to the Gene-Server
will be kept but not responded to until we can get this problem worked
out. It should be no more than a day or two.

Gopher and FTP services remain up as normal.


dan davison
gene-server manager
Newsgroups: bionet.software
From: bowman@reed.edu (Eric Bowman (bobo))
Subject: Re: object-oriented BASIC???
Organization: Reed College, Portland, OR
Date: Thu, 27 Aug 1992 21:04:10 GMT

In article <27AUG92.12080846@wums.wustl.edu> wetsel_r@wums.wustl.edu writes:
>YES!  BASIC can be OOP.  Originally, BASIC was seriously flawed as one
>could just write anything one wanted without regard to format or structure.
> Recently, the Microsoft (and a few others) modified BASIC in such a way so
>that one would be "coaxed" into an OOP format -- thus the QuickBasic
>Compliers were born.  I can attest to this from personal experience. 
>Subroutines in QuickBasic become what are called modules, where a program
>is actually a collection of modules held together with a central program. 
>Many books on advanced QuickBasic programming exist which allow one to
>setup 'pop-up' windows and make your program easier on the eye and the
>end-user.  

I think you are confused. QuickBasic is *not* an OOPL.  It is somewhat more
evolved than vanilla BASIC since it allows structured programming.  It may
even allow certain primitive OOP techniques, but I think they are limited;
QuickBasic for the Mac doesn't really support pointers; the PC version may;
I know it's considerably better than the Mac version.

>However, when BASIC (through Quickbasic) was going through this
>evolution, C came along and I know of a number of BASIC programmers who
>jumped ship.   

Huh?!? BASIC: 1967.  C : 1973.  QuickBasic:  mid '80's.

>To answer your question, Yes, BAsic can be OOP through the QuickBasic Compiler.
>Easily obtained at your local discount Software store, PC-MAG, Egghead...

Well...QuickBasic allows some pretty sophisticated (for BASIC) structured
programming techniques; using them, one can employ certain object-oriented
techniques, just as one can do the same thing in C or Pascal.  
However, QuickBasic is *not* an OOPL in the sense of C++, Objective
C, Object Pascal, or SmallTalk.  I highly doubt it will ever become an OOPL;
I just don't think there's any reason for it.  There are far better languages.

Just my $0.02,
bobo
bowman@reed.edu
From: joseph@valis.biocad.COM (Joseph Truitt)
Newsgroups: bionet.software
Subject: Re: Pharmacokinetics s/w
Date: 4 Sep 92 00:04:32 GMT

In message <1992Sep2.060818.21203@ccu1.aukuni.ac.nz>,
nholford@ccu1.aukuni.ac.nz (Nick Holford) writes:
>joseph@valis.biocad.COM (Joseph Truitt) writes:
>>In message <Btouxp.KxF@gate.demon.co.uk>,
>>James Petts <visigoth.demon.co.uk!pettsj> writes:
>>>I am looking for software to do pharmacokinetic modelling
>>----- begin forwarded message from Dale Mehl of BioCAD -----
>>You might be interested in Catalyst, BioCAD's drug discovery software
>What this shows is that BioCad has no idea what pharmacokinetics means!
>PK is what the body does to the drug (absorption, distribution, elimination)
>PD is what the drug does to the body (drug effects)

----- begin forwarded message from Dale Mehl of BioCAD -----

Thank you for the succinct definitions of PK and PD.  The problem here
is that I am new to BioCAD's marketing department and I'm starting up
the learning curve.  After speaking with one of the medicinal chemists
here, I now understand the difference between pharmacokinetics and
pharmacophores.

Sorry to have inconvenienced you.

----- end forwarded message -----

 ___________________________________________________________________________
|                                                                           |
| joseph@biocad.com 415/903-3923                                            |
From: pw@CUBMOL.BIO.COLUMBIA.EDU (Paul Wakenight)
Newsgroups: bionet.software
Subject: OLIGOS
Date: 2 Sep 92 00:15:05 GMT
Distribution: bionet

We are considering buying a program called OLIGOS - which estimates Tm, etc.
for primers, etc.  Does anyone have experience with this program? Is there 
some ugly, but functional Unix/Dox shareware that does the same stuff?  It
appears to me that the $400 cost is mainly for colored screens and easy to
use menus.   
Thanks.

pw@cubmol.bio.columbia.edu
From: JONESBB@BELOIT.EDU
Newsgroups: bionet.software
Subject: Re: Mac to PC disk utility?
Date: 27 Aug 92 18:57:00 GMT
Distribution: bionet


All Macs come with the Apple File Exchange utility.  That lets you read, write,
and format IBM 3.5" diskettes in the Mac drive.  You may have to save your data
in a text-only file that can be read by the target application on the IBM.

The Apple File Exchange is an application, and you must run it in order to move
anything on or off the IBM floppy.  If you don't mind paying for a utility, you
might be interested in DOS Mounter, which is an INIT.  If that is in your system
folder, then when you put a DOS diskette into the drive, it is recognized as
a DOS disk and is mounted on the desktop just like a Mac disk.  DOS mounter
converts the format on the fly.  It is also available with translation software
so that it can also translate between two different applications on the fly as
well, such as between Lotus and Excel.  That is, once you configure it, when
you open a DOS disk that has a Lotus file on it, you see an icon for an Excel
file.  You can double click on it and it will launch Excel, you can make your
changes, save it and close it, and then take the disk back to your IBM and 
open it in Lotus.

I understand that there may be another similar commercial package as well.
In general, all three are capable of using translation software (such as the
MacLink Translators) which convert the FILE format as well as move files back
and forth between floppies.

Ben Jones, BioQUEST
From: hou@agouron.com (Xinjun Hou)
Newsgroups: bionet.software
Subject: Re: Mac to PC disk utility?
Date: 28 Aug 92 20:23:03 GMT
Distribution: bionet
Organization: Agouron Pharmaceuticals, Inc., San Diego, CA

In article <01GO2U9N3QS08WVYHT@beloit.edu> JONESBB@BELOIT.EDU writes:
>
>All Macs come with the Apple File Exchange utility.  That lets you read, write,
>and format IBM 3.5" diskettes in the Mac drive.  You may have to save your data
>in a text-only file that can be read by the target application on the IBM.
>
>
Apple File Exchange can do that only if the Mac has 1.44 high density
dirve(Super dirve).  (Mac Plus, and some old SE do not have superdirve)

- 

-- 
Xinjun Jason Hou                                       010110000110100101101110
Agouron Pharmaceticals, Inc                            011010100111010101101110
hou@agouron.com                                        010010000110111101110101
From: DUBINSE@EARN.DUVM ("S. Dubin")
Newsgroups: bionet.software
Subject: Software to manage inbred rodent colony
Date: 27 Aug 92 11:55:25 GMT
Distribution: bionet
Original-To: smdm-l@EARN.DARTCMS1, compmed@EARN.WUVMD, agris-l@EARN.IRMFAO01,
        biosoftware@UK.AC.DARESBURY

Before I attempt to reinvent the wheel, I wonder whether anyone on
these lists has used or knows about software to manage an inbred rodent
colony. The colony "owner" is interested in modeling the production
with a view to planning for future use goals.  The strain has a
recessive trait which also limits reproductive capacity so that breeding
is done from the heterozygous individuals.
Thanks for help and apologies for cross-posting.
 +=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=+
 |                 Stephen Dubin VMD PhD                     |
 |     Biomedical Engineering and Science Institute          |
 |     Drexel University,  Philadelphia  PA  19104           |
 |       Phone: 215-895-2219   Fax: 215-895-4983             |
 |   Email: dubinse@duvm.ocs.drexel.edu   CIS: 76074,55      |
 +=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=+
 
 
 
Newsgroups: bionet.software
From: gilbertd@sunflower.bio.indiana.edu (Don Gilbert)
Subject: IUBio archive temporarily closed
Keywords: file translation
Organization: Biology, Indiana University - Bloomington
Distribution: bionet
Date: Mon, 31 Aug 1992 22:57:29 GMT


The gopher and ftp archive at ftp.bio.indiana.edu is 
temporarily closed (and has been much of today).  I hope
it will be back tomorrow.  I'm having problems with
an Internet cracker who knows more about Sun security
holes than I do.

-- Don
-- 
Don Gilbert                                     gilbert@bio.indiana.edu
biocomputing office, biology dept., indiana univ., bloomington, in 47405
From: danj@WELCHGATE.WELCH.JHU.EDU (Dan Jacobson x-8453)
Newsgroups: bionet.software
Subject: Re: Re: Pima users
Date: 31 Aug 92 14:21:10 GMT
Distribution: bionet


Ed Rybicki writes:

>I am very interested in any and all VAX software for multiple sequence
>alignment / phylogeny generation: please could some kind soul send me the info
>on PIMA (and how to get it)?


Well sorry Ed, at this time PIMA will only work under Unix.  If you have access
to a Unix box and want to get it  by anonymous ftp the closest place to you 
would probably be:

nic.funet.fi

in the /pub/sci/molbio/unix  directory.

It is also available at ftp.bio.indiana.edu and ftp.bchs.uh.edu,
kudos go to Rob, Don and Dan for the ftp sites.


Best of luck,

Dan Jacobson
From: roseann@badger.Berkeley.EDU (Roseann Maret White)
Newsgroups: bionet.software
Subject: Molbio software
Date: 27 Aug 92 16:46:53 GMT
Organization: Dept. of Statistics, U. C. Berkeley


I am interested in finding out where there are listings of software
for Molecular Biology.  I know it would be to much to expect that there is
a catalog or a magazine that one could subscribe to that will list
these programs short blurbs and contact people.  However, if there
is something along these lines I would like to know.

Thanks,
R White
From: dbd@THEORY.BCHS.UH.EDU (Dan Davison)
Newsgroups: bionet.software
Subject: PDB available for FTP *temporarily* from the Gene-Server
Date: 28 Aug 92 22:57:52 GMT
Distribution: bionet

The PDB coordinate files (pdbxxx.ent) are available from the
UH Gene-server via anonymous FTP (ftp.bchs.uh.edu, 129.7.2.43)
in ~ftp/pub/gene-server/pdb/...

These files are compressed, so you will need a version of uncompress
to convert them to readable text files.  Be sure to FTP them in
binary mode!

These files are from the "PDB CD Sampler, Summer 1992" and will be
available ONLY between 5PM and 9AM Central time weekdays, but
full time on weekends. You will get a surprise if you try to FTP 
the whole directory.

They will also only be available until the PDB gets its own, 
comprehensive FTP site running, some time in the fall.

The ftp area contains ONLY the coordinate files; no index files are
available here. Also no "pre-release" coordinates are here: see the
PDB's ftp area for that.  Specific entries should be looked up using
the PDB's WAIS server then fetched from the Gene-Server via FTP.

See the file "advisory.doc" for important re-distribution information.
Part of it is:

                                                                                
      IT IS A COMMON GOAL OF THE NATIONAL SCIENCE FOUNDATION, THE
 NATIONAL INSTITUTES OF HEALTH, AND THE DEPARTMENT OF ENERGY TO HAVE
 THE RESULTS OF WORK WHICH THEY SUPPORT MADE AVAILABLE TO THE PUBLIC
 AND DISSEMINATED AS WIDELY AS POSSIBLE.  THE PROTEIN DATA BANK
 DATABASE IS BEING MADE AVAILABLE TO THE PUBLIC IN FURTHERANCE OF
 THAT COMMON OBJECTIVE.  IT SHOULD BE NOTED, HOWEVER, THAT IT IS
 IMPROPER FOR ANY RECIPIENT OF THE PROTEIN DATA BANK DATABASE TO
 OFFER SAID COMPUTER FILES, MAGNETIC TAPES, MICROFICHE, LISTINGS, OR
 ANY FURTHER PROTEIN DATA BANK PRODUCT OR COPIES THEREOF FOR SALE AS
 A COMMERCIAL ITEM.


Remember, this is temporary and will be removed if abused. All FTP
transactions are logged.

dan davison
Gene-Server manager
From: BIONET@EARN.FRCGM51
Newsgroups: bionet.software
Subject: Re: Predicting transmembrane proteins
Date: 2 Sep 1992 16:49:00 GMT
Distribution: bionet
X-Envelope-To: bio-software@daresbury.ac.uk
Original-To: bio-software@UK.AC.DARESBURY
X-Vms-To: IN%"bio-software@daresbury.ac.uk"


 
        I got some time ago a program called ALOM from Don Gilbert (see
Fasman & Gilbert, TIBS 15, 1990, 89-92) which predicts transmembrane spans
according to Klein, Kanehisa & De Lisi (BBA 815, 1985, 468-476).
        The source code was available by ftp to VAX.WI.EDU, directory
ANONYMOUS.TIBS.KKD
        Good luck!
---
J-L. Risler                                     Bionet@frcgm51.bitnet
Centre de Genetique Moleculaire                 Risler@frcgm51.bitnet
91190 Gif sur Yvette   France
Organization: Queen's University at Kingston
Date: Wednesday, 2 Sep 1992 17:50:33 EDT
From: Jim Gerlach <GERLACHJ@QUCDN.QueensU.CA>
Newsgroups: bionet.software
Subject: Re: Help re: predicting transmembrane domains.
Distribution: bionet

In article <1992Sep1.193439.3081@magnus.acs.ohio-state.edu>,
gchacko@magnus.acs.ohio-state.edu (George W Chacko) says:
>
>I was told that an algorithm developed by Klein, Kanchesa and D'Lisi
>exists which is of use in predicting hydrophobic regions in proteins.
>Could any one provide more information please?

The reference is Biochim. Biophys. Acta 815:468-476, 1985. The program is
available as part of the PC/Gene package. Does anyone know of a public
domain or shareware version of the program?

Jim

Jim Gerlach - Cancer Research Laboratories
James.H.Gerlach@QueensU.CA                    Queen's University
GERLACHJ@QUCDN.QueensU.CA (NetNorth/BITNET)   Room A309A, Botterell Hall
tel (613) 545-6446                            Kingston, Ontario
fax (613) 545-6830                            CANADA  K7L 3N6
From: mangalam@SALK-SC2.SDSC.EDU
Newsgroups: bionet.software
Subject: Re:  InsightII via X
Date: 2 Sep 92 21:55:15 GMT
Distribution: bionet


 Hi,
   Re: Running the Biosym software InsightII/Discover over a network via
Xwindows.
   In the continuing quest for truth, justice, and the Biosym way, I called
the the response center to inquire directly as to the possibility of having
the display set to a different networked machine.  The answer was on 2
levels.  
   The first was that you can set the display to another networked SGI, but
ONLY if both machines are licensed for the software.  If you can get
another (unlicensed) SGI to display the InsightII output from a licensed
machine, you are in violation of your agreement.  They were quite definite.
 
   The second is that as they understood it, a plain X terminal (without GL
support) will not be able to display the image anyway.  This may change if
software/hardware makers start to implement OpenGL as a value-added feature
to standard X, but not for a long time.
   So it seems that dreams (mine, anyway) of being able to drive multiple
(cheap) Xwin terminals and/or emulators from one (big!) SGI are not going
to happen soon.

Cheers,

Harry


Harry Mangalam                                   Vox:(619) 453-4100, x250
Dept of Biocomputing                                   Fax:(619) 552-1546
The Salk Institute                             mangalam@salk-sc2.sdsc.edu
10010 N Torrey Pines Rd                        mangalam@salk-sgi.sdsc.edu
La Jolla CA 92037                                    mangalam@salk.bitnet
From: dacoo@BE.AC.ULB
Newsgroups: bionet.software
Subject: Pima users
Date: 26 Aug 92 13:44:33 GMT
Distribution: bionet
Original-To: bio-soft@UK.AC.DARESBURY
X-Mailer: ELM [version 2.3 PL11]

hello,netters
 
I am now beginning to use the Pattern Induced Multiple Alignement (PIMA
1.22)
package . I meet a very strange problem. Apparently the make-cluster.sh
file contains an instruction :'cat -n ...'
This instruction is not recognized by our system here, I tried to suppress
but no results appear on the screen. Does someone of you know what is it
supposed to do and by what can I replace it. (probably a combination of
others cat parameters)
Coornaert David
Brussels free University, belgium
In advance thanks a lot.
Newsgroups: bionet.software
From: csb@jax.org (Carolyn Blake)
Subject: GRAIL?
Organization: The Jackson Laboratory, Bar Harbor, ME 04609
Date: Thu, 27 Aug 92 13:49:05 GMT

I'd like any information on the DNA sequencing program (package?)
'GRAIL'.

Thanks for the help!

Carolyn Blake
The Jackson Laboratory
600 Main Street
Bar Harbor, ME  04609
Newsgroups: bionet.software
Subject: Re: Pharmacokinetics s/w
From: nholford@ccu1.aukuni.ac.nz (Nick Holford)
Date: Wed, 2 Sep 1992 06:08:18 GMT
Organization: University of Auckland, New Zealand.

joseph@valis.biocad.COM (Joseph Truitt) writes:

>In message <Btouxp.KxF@gate.demon.co.uk>,
>James Petts <visigoth.demon.co.uk!pettsj> writes:
>>I am looking for software to do pharmacokinetic modelling, preferably for 
>>the Mac, but Un*x s/w would be acceptable too. Any suggestions would be 
>>most appreciated. E-mail or postings are fine.

>----- begin forwarded message from Dale Mehl of BioCAD -----

>You might be interested in Catalyst, BioCAD's drug discovery software
>system.

>Catalyst is used to speed the drug discovery process.  It provides a
>means for conceptualizing ligand-receptor relationships in 3D and is an
>effective tool for designing new biologically active molecules. 
[Stuff deleted]

What this shows is that BioCad has no idea what pharmacokinetics means!
PK is not ligand binding and molecular modelling. 
For the record a simple definition:
 PK is what the body does to the drug (absorption, distribution, elimination)
 PD is what the drug does to the body (drug effects)

-- 

Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, Auckland, New Zealand
INTERNET: n.holford@aukuni.ac.nz
From: little@ERE.UMontreal.CA (Littlejohn Tim)
Newsgroups: bionet.software
Subject: Re: Mac to PC disk utility?
Date: 1 Sep 92 18:03:38 GMT
Distribution: bionet
Organization: Universite de Montreal

In article <0095FB82.134397D0.289@NTBTOX.NCTR.FDA.GOV> wmelchior@NTDOC.NCTR.FDA.GOV writes:
>The Mac on our new ABI 373 sequencer is not yet networked, and we have no
>other Mac handy.  Does anyone know of a utility that will let us transfer
>data from the Mac to a PC via 3 1/2" disk?  Since the Mac can't talk to
>anyone but another Mac right now, this would probably have to be something
>that would let a PC read a Mac disk.

Try looking in the simtel archive:

PD1:<MSDOS.MAC>

The file MAC2IBM.ARC has a description that suggests it may be useful
for file exchange from a Mac disk to the PC.

Good luck!

Tim

==============================================================================
E-mail:     little@ere.umontreal.ca         Tim Littlejohn 
                                               
Snail Mail: Departement de biochimie        Phone: (514) 343-7936
            Universite de Montreal          Fax:   (514) 343-2210 
            C.P. 6128, succursale A,
            Montreal (Quebec), H3C 3J7
            CANADA
==============================================================================
From: BIONET@EARN.FRCGM51
Newsgroups: bionet.software
Subject: Re: Re: Predicting transmembrane proteins
Date: 4 Sep 92 12:32:00 GMT
Distribution: bionet
X-Envelope-To: BIO-SOFTWARE@DARESBURY.AC.UK
Original-To: BIO-SOFTWARE@UK.AC.DARESBURY
X-Vms-To: IN%"BIO-SOFTWARE@DARESBURY.AC.UK"


 
        Concerning a freeware program based on the KKD algorithm:
 
        Some time ago I ftp'd a program by William Gilbert called ALOM (see
TIBS 15, 89-92, 1990) from his server at VAX.WI.EDU, directory
ANONYMOUS.TIBS.KKD.
 
        Nice program, quite fast, can handle a list of sequence names.
 
   ---------------------------------------------------------------
  | J-L. Risler                         |                         |
  | CNRS                                |  Bionet@frcgm51.bitnet  |
  | Centre de Genetique Moleculaire     |  Risler@frcgm51.bitnet  |
  | 91190 Gif sur Yvette   France       |                         |
   ---------------------------------------------------------------
From: 100012.1163@CompuServe.COM ("Rainer Stumpe 100012,1163")
Newsgroups: bionet.software
Subject: subs
Date: 30 Aug 92 07:36:38 GMT
Distribution: bionet

subscribe BIO-SOFTWARE Rainer Stumpe
help
info BIO-SOFTWARE
From: mangalam@SALK-SC2.SDSC.EDU
Newsgroups: bionet.software
Subject: Re: IUBio archive temporarily closed
Date: 1 Sep 92 16:55:01 GMT
Distribution: bionet

Don (the cukoo's egg) Gilbert writes:

>The gopher and ftp archive at ftp.bio.indiana.edu is 
>temporarily closed (and has been much of today).  I hope
>it will be back tomorrow.  I'm having problems with
>an Internet cracker who knows more about Sun security
>holes than I do.
>
>-- Don

   Once you sort things out, I (and the net?) would be interested in a
short summary of your experiences, if you could spare the time.  I've never
(to my knowledge.....8^) ) been hacked - how did you find out, how did you
respond, how did the hacker respond, etc?
   
Good Luck,

Harry


Harry Mangalam                                   Vox:(619) 453-4100, x250
Dept of Biocomputing                                   Fax:(619) 552-1546
The Salk Institute                             mangalam@salk-sc2.sdsc.edu
10010 N Torrey Pines Rd                        mangalam@salk-sgi.sdsc.edu
La Jolla CA 92037                                    mangalam@salk.bitnet
From: ES@UK.AC.AFRC.JII
Newsgroups: bionet.software
Subject: Re: Program to draw polypeptide figures
Date: 31 Aug 92 15:41:00 GMT
Distribution: bionet
Original-To: BIO-SOFTWARE@UK.AC.DARESBURY

Dear Netw,

If it exists, could the answer of the request about s/w to draw 
polypeptides as a defined backbone with aa in circles be posted to the
network? I know of several people, including myself who would be interested.
Thanks.