From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens peroxisomal 70 kD membrane protein mRNA, complete cds.
Date: 6 Nov 92 18:07:40 GMT
Distribution: bionet
Checksum: 22086 7

LOCUS       HUMPMP       3397 bp ss-mRNA            PRI       28-OCT-1992
DEFINITION  Homo sapiens peroxisomal 70 kD membrane protein mRNA, complete cds.
ACCESSION   M81182
KEYWORDS    ABC protein; ATP-binding cassette protein;
            peroxisomal membrane protein.
SOURCE      Homo sapiens liver cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Gaertner,J., Oble,C., Moser,H. and Valle,D.
  TITLE     A polymorphic synonymous mutation (K54K) in the human 70 kD
            peroxisomal membrane protein gene (PMP1)
  JOURNAL   Hum. Mol. Genet. 1, 654-654 (1992)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Gaurtner,J., Moser,H. and Valle,D.
  TITLE     Mutations in the 70 kD peroxisomal membrane protein in Zellweger
            syndrome
  JOURNAL   Nature Genet. 1, 16-23 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             1..1980
                     /gene="PMP1"
                     /product="peroxisomal 70 kD membrane protein"
                     /codon_start=1
                     /translation="MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPP
                     LQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVW
                     MIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTK
                     YLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYI
                     FKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNS
                     EEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVS
                     RPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARIT
                     ELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATP
                     NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYV
                     PQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQD
                     WMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVS
                     HRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS"
BASE COUNT     1052 a    581 c    700 g   1064 t
ORIGIN      chromosome 1
        1 atggcggcct tcagcaagta cttgacggcg cggaactcct cgctggctgg tgccgcgttc
       61 ctgctgctct gcctgctcca caagcggcgc cgcgccctcg gcctgcacgg taagaaaagt
      121 ggaaaaccac cattacagaa caatgagaaa gaggggaaaa aagagcgagc tgtggtggac
      181 aaggtgtttt tctcaaggct catacagatt ctgaaaatca tggtccctag aacattttgt
      241 aaagagacag gttacttggt acttattgct gttatgctgg tgtctcgaac atattgtgat
      301 gtttggatga ttcaaaatgg gacactaatt gaaagtggta tcattggtcg tagcaggaaa
      361 gatttcaaga gatacttact caacttcatc gctgccatgc ctcttatctc tctggttaat
      421 aacttcttga agtatgggtt aaatgagctt aaactgtgct tccgagtaag gctcactaaa
      481 tacctctatg aggagtatct tcaagctttc acatattata aaatggggaa tctggacaac
      541 agaatagcta atccagacca gctgcttaca caagatgtag aaaaattttg taacagtgta
      601 gtcgatctgt attcaaatct tagtaagcca tttttagaca tagttttgta tatctttaag
      661 ttaacgagtg caattggagc tcagggccca gcgagcatga tggcctactt ggttgtttct
      721 gggctattcc taactcgact tcgaagaccc attggtaaga tgacaataac tgagcaaaag
      781 tatgaaggag aatatagata tgttaattct cggctcatca caaacagtga agaaattgcc
      841 ttttacaatg ggaataaaag agaaaagcag acagtccact cagtcttccg aaaactggtg
      901 gaacacctac ataatttcat tttgtttcgg ttttcaatgg gcttcattga tagtattatt
      961 gccaaatacc ttgccactgt tgttggttac ctagttgtca gtcgcccttt cttagatttg
     1021 tctcatcctc gacatctcaa gagtacacat tcggaacttc tagaggatta ctaccaaagt
     1081 ggaagaatgc ttttgcgaat gtctcaagct ctgggtcgaa tagttttggc tgggcgtgaa
     1141 atgactagat tggccggttt tactgctcgg attacagaat taatgcaagt actgaaggat
     1201 ttaaatcatg gcaaatatga gcgcacaatg gtctcacaac aggaaaaggg tattgaagga
     1261 gtacaagtca ttcccttgat acctggtgct ggagaaatca ttattgcaga taacattata
     1321 aagtttgatc atgttccttt agcaacgcca aatggagatg ttttgatccg agaccttaat
     1381 tttgaagttc gatctggggc taatgttcta atttgtggtc caaatggctg cggaaagagt
     1441 tcacttttcc gtgttcttgg tgaattatgg cctctttttg gaggacgtct aactaaacct
     1501 gaaagaggaa aattatttta tgttcctcag agaccttaca tgacccttgg aacacttcga
     1561 gatcaagtga tatatccaga tggacgagaa gatcagaaaa ggaagggaat ttctgaccta
     1621 gtactgaagg aatacttaga caatgtccag ttgggtcata tccttgaacg tgaaggaggc
     1681 tgggacagtg ttcaggattg gatggacgta ctcagtggtg gagaaaagca aagaatggcg
     1741 atggcaagat tattttatca taaaccccag tttgccattt tggatgaatg cacaagtgca
     1801 gttagtgtcg acgtggaagg ctacatttat agtcattgtc gaaaggttgg catcactctc
     1861 ttcactgtgt ctcataggaa atctctttgg aaacatcatg agtactacct gcatatggat
     1921 ggcagaggca actatgaatt caaacagata acagaagata cagttgagtt tggctcttag
     1981 agaaatctgg agaactatac ctgcttcagt gaaataatta cagaatatac ttagaaaggc
     2041 aaagtacatt gtaaaataaa gttgagctta gtttttttta aaaaaaaaaa acaaagcaac
     2101 aaattaacta gatacagaat aatggagaac aagttgttaa aacatttaat attatatagg
     2161 atattgctaa ttgtgtatat gttggtttaa ttaataatat gtactaagaa tgtccttatt
     2221 cttgtggtta aaaacctgcc taaattaaat tgggcttcaa tcactgtaac ctgattcatc
     2281 ctgggatgta aaccattcga agtcagctaa ttggactttt atggctctat cttttccttc
     2341 agtgaagaac cctatttaaa actgggtcat catttgtcct gttctagcaa gatagtcttc
     2401 agtttcattt tcctgtgccc tgtggtagtt ggaaacaaat cataatgtat tatttaaatg
     2461 tttaacatca ttgcataaca gcgtttatta tacagtggca gatttcttta gctgccacag
     2521 taatactcat tccttgtgtg tgtcttggag tgcatttgac tccaggaaaa gccattttgg
     2581 ttttccttaa ctaaatgata aatgtacccc tctcagtctg cagtattgag ttgtttaaag
     2641 tatatgtgca gtcttgctta caaggagggg ttaccatgta tcacacctaa tcttcccaat
     2701 gtttgggata ttaaaacaca aagtccttaa catgccaggc tcaaggtctt ataagagttc
     2761 tagattttta agagaattag acaaatttgt gtgtgttaga agcccattca ttagaagtgt
     2821 ggtggttatt tggtattaaa ctccaaatga gccataggaa ggcactacat gaaataatgc
     2881 actgagtatg caatgctatc actgtctttg actgtgattt tatgtttaaa aagtatgttc
     2941 taaaattatt atatatacat gggtgaatta tgtttccgag gcactgtttt atctctgtga
     3001 atcttgaata acttttttat atttgggtta tgatgtcaaa cgatcctaag cgaagatgat
     3061 ttcagttcat caaatcatca ttaatgactt tatgtattat ttgcacaggg agaattgaaa
     3121 ctgagtataa tcaataagct agatacgaaa tcagtttctc aaactgagct tcagaaaggg
     3181 gcattttgta ctcttgtttt tgcataactg gttttgtttt tttgcagaat taactataac
     3241 aatcactggc taccgaagta aactgatgta ctgaattcca taatacataa cattcaattt
     3301 ttaccacttc tgtttagcga acttgtatac ttattttctg ttcagattaa aaaaaaaaaa
     3361 aaaaaaaact cagatatcct ataaaaaaaa aaggaat
//