From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Xenopus laevis mRNA fragment for IgM VH-region (J4)
Date: 22 Dec 92 22:47:48 GMT
Distribution: bionet
Checksum: 14127 3

LOCUS       XELIMVJ4      386 bp ss-mRNA            VRT       23-NOV-1992
DEFINITION  Xenopus laevis mRNA fragment for IgM VH-region (J4)
ACCESSION   X14921 M37533 M37539 X12551
KEYWORDS    complementarity determining region; constant region.
SOURCE      Xenopus laevis RNA.
  ORGANISM  Xenopus laevis
            Eukaryota; Animalia; Chordata; Vertebrata; Amphibia; Lissamphibia;
            Anura; Archeobatrachia; Pipoidea; Pipidae; Xenopodinae.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Schwager,J., Grossberger,D. and Du Pasquier,L.
  TITLE     Organisation and rearrangement of immunoglobulin M genes in the
            amphibian Xenopus
  JOURNAL   EMBO J. 7, 2409-2415 (1988)
  STANDARD  full automatic
COMMENT     *source: tissue=blood; cell type=erythrocyte; library=lambda EMBL3;
            *source: clone=J4;
               From EMBL 27   entry XLIMVJ4;  dated 29-JAN-1990.
FEATURES             Location/Qualifiers
     misc_feature    29..109
                     /note="FR1 region"
     misc_feature    110..136
                     /note="CDR1 region"
     misc_feature    137..178
                     /note="FR2 region"
     misc_feature    179..226
                     /note="CDR2 region"
     misc_feature    227..321
                     /note="FR3 region"
     misc_feature    322..340
                     /note="CDR3 region"
     misc_feature    341..373
                     /note="FR4 region"
     CDS             <1..>386
                     /note="(AA -6 to 121) (1 is 3rd base in codon) (386 is 1st
                     base in codon)"
                     /note="pre-IgM VH-region"
                     /codon_start=2
                     /translation="LQCVTCQISLTQPGAVTVKPSEVLQLTCKVTGASLTDSSKVYSF
                     QWVREPAAKGLEWLGGIWHDAGTHYAQSLQGRITASRDTNKGEVYLKLTGMKPEETAV
                     YYCAIYGGFDYWGQGTMVTVTSATSK"
     CDS             <1..16
                     /note="(AA -6 to -1) (1 is 3rd base in codon)"
                     /note="signal peptide"
                     /codon_start=1
                     /translation="VAVCD"
     CDS             20..>386
                     /note="(AA 1 - 121) (386 is 1st base in codon)"
                     /note="IgM VH-region"
                     /codon_start=1
                     /translation="QISLTQPGAVTVKPSEVLQLTCKVTGASLTDSSKVYSFQWVREP
                     AAKGLEWLGGIWHDAGTHYAQSLQGRITASRDTNKGEVYLKLTGMKPEETAVYYCAIY
                     GGFDYWGQGTMVTVTSATSK"
BASE COUNT      103 a     89 c    102 g     92 t
ORIGIN      
        1 gttgcagtgt gtgacatgtc agatctccct gacacagcct ggtgctgtca ctgtgaagcc
       61 atcagaggtt cttcagttga cctgtaaagt gaccggagcc tccctcactg acagctccaa
      121 agtatattca ttccagtggg tccgtgagcc tgcagcgaaa gggctggagt ggctgggagg
      181 gatatggcat gatgctggca cacactatgc ccagtctttg cagggacgca tcacagcatc
      241 aagagacaca aataaaggag aagtttattt aaaactcact ggaatgaaac cagaggaaac
      301 tgctgtatat tactgtgcta tttacggggg ctttgactac tggggacaag ggaccatggt
      361 caccgtcact tcagctactt caaaat
//