From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human T-cell receptor germline gamma-chain pseudogene V-region (V1;
Date: 7 Jan 93 05:51:35 GMT
Distribution: bionet
Checksum: 03275 4

LOCUS       HUMTCGVA1     495 bp ds-DNA             PRI       06-JAN-1993
DEFINITION  Human T-cell receptor germline gamma-chain pseudogene V-region (V1;
            subgroup I).
ACCESSION   M12949
KEYWORDS    T-cell antigen receptor; T-cell receptor gamma-chain; germline;
            pseudogene; variable region.
SEGMENT     1 of 7
SOURCE      Human B-lymphoblastoid cell line SH DNA, clone lambda-SH4.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Lefranc,M.-P., Forster,A., Baer,R.J., Stinson,M.A. and
            Rabbitts,T.H.
  TITLE     Diversity and rearrangement of the human T cell rearranging gamma
            genes: Nine germ-line variable genes belonging to two subgroups
  JOURNAL   Cell 45, 237-246 (1986)
  STANDARD  full automatic
COMMENT     Printed copy of the sequence in [1] was kindly provided by
            M.-P.Lefranc, 01-AUG-1986. Revisions to the entry also kindly
            provided by M.-P. Lefranc, 22-JUN-1988.  The conserved putative
            signal sequences for VJ recombination are found from positions 471
            to 495. There is a 14 bp deletion between the nonomer and heptamer
            sequences in this pseudogene.
FEATURES             Location/Qualifiers
     CDS             join(<1..43,163..470)
                     /pseudo
                     /gene="TCRGV1"
                     /codon_start=1
                     /partial
                     /note="pseudo-V1 gamma"
     exon            <1..43
                     /number=1
                     /gene="TCRGV1"
     intron          44..162
                     /number=1
                     /gene="TCRGV1"
     exon            163..470
                     /number=2
                     /gene="TCRGV1"
     iDNA            (470.472)..>495
                     /gene="TCRGV1"
                     /note="V-J intervening DNA"
     misc_signal     471..477
                     /gene="TCRGV1"
                     /note="heptamer recombination signal; putative"
     misc_signal     487..495
                     /gene="TCRGV1"
                     /note="nonamer recombination signal; putative"
     misc_feature    1..495
                     /note="This feature applies to a gene which lacks a coding
                     region feature. "
                     /gene="TCRGV1"
BASE COUNT      125 a    112 c    120 g    138 t
ORIGIN      281 bp upstream of KpnI site; chromosome 7.
        1 atgcggtggg ccctagcggt gcttctagct ttcctgtctc ctggtgagtg cgctgcctac
       61 agagaggatc acgggtcttg ttttgttttg ttattttctt cttttgcaag gagcgacata
      121 ctaagaaatg cctcattata ttttgtgttg ttcccattgc agccagtcag atatcttcca
      181 acttggaagg gagaacgaag tcagtcacca ggctgactgg gtcatctgct gaaatcacct
      241 gtgatcttcc tggagcaagt accttataca tccactggta cctgcaccag gaggggaagg
      301 ccccacagtg tcttctgtac tatgaaccct actactccag ggttgtgctg gaatcaggaa
      361 tcactccagg aaagtatgac actggaagca caaggagcaa ttggaatttg agactgcaaa
      421 atctaattaa aaatgattct gggttctatt actgtgccac ctgggacagg cacagtgatt
      481 cagacactga aaatc
//