From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human fibrinogen alpha chain gene, complete mRNA.
Date: 6 Nov 92 18:06:33 GMT
Distribution: bionet
Checksum: 02252 11

LOCUS       HUMFIBRA     5943 bp ds-DNA             PRI       28-OCT-1992
DEFINITION  Human fibrinogen alpha chain gene, complete mRNA.
ACCESSION   M64982
KEYWORDS    fibrinogen; fibrinogen alpha-chain.
SOURCE      Homo sapiens unknown fetal liver DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5943)
  AUTHORS   Chung,D.W., Harris,J.E. and Davie,E.W.
  TITLE     Nucleotide sequences of the three genes coding for human fibrinogen
  JOURNAL   (in) Liu,C.Y. and Chien,S. (Eds.); Fibrinogen, Thrombosis,
            Coagulation and Fibrinolysis:  39-48, Plenum Press, New York (1991)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     mRNA            join(1..84,1154..1279,1739..1922,3055..3200,3786..5210)
                     /product="fibrinogen alpha chain"
                     /gene="FGA"
     exon            1..84
                     /number=1
                     /gene="FGA"
     intron          85..1153
                     /number=1
                     /gene="FGA"
     exon            1154..1279
                     /number=2
                     /gene="FGA"
     intron          1280..1738
                     /number=2
                     /gene="FGA"
     exon            1739..1922
                     /number=3
                     /gene="FGA"
     intron          1923..3054
                     /number=3
                     /gene="FGA"
     exon            3055..3200
                     /number=4
                     /gene="FGA"
     intron          3201..3785
                     /number=4
                     /gene="FGA"
     exon            3786..5210
                     /number=5
                     /gene="FGA"
     3'UTR           5211..5427
                     /gene="FGA"
     misc_RNA        5428..5943
                     /function="3'flanking sequence"
                     /gene="FGA"
                     /note="putative"
     CDS             join(31..84,1154..1279,1739..1922,3055..3200,3786..5210)
                     /note="putative"
                     /product="fibrinogen alpha chain"
                     /codon_start=1
                     /translation="MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQ
                     SACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDS
                     HSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVR
                     AQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDR
                     QHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTS
                     YGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSAGSW
                     NSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGS
                     FRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVT
                     SGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG
                     FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPG
                     IAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHA
                     KSRPVRGIHTSPLGKPSLSP"
BASE COUNT     1772 a   1193 c   1218 g   1760 t
ORIGIN      
        1 gtctaggagc cagccccacc cttagaaaag atgttttcca tgaggatcgt ctgcctagtt
       61 ctaagtgtgg tgggcacagc atgggtatgg cccttttcat tttttcttct tgctttctct
      121 ctggtgttta ttccacaaag agcctggagg tcagagtcta cctgctctat gtcctgacac
      181 actcttagct ttatgacccc aggcctggga ggaaatttcc tgggtgggct tgacacctca
      241 agaatacagg gtaatatgac accaagagga agatcttaga tggatgagag tgtacaacta
      301 caagggaaac tttagcatct gtcattcagt cttaccacat tttgttttgt tttgttttaa
      361 aaagggcaag aattatttgc catccttgta cctataaagc cttggtgcat tataatgcta
      421 gttaatggaa taaaacattt tatggtaaga tttgttttct ttagttatta atttcttgct
      481 acttgtccat aataagcaga acttttagtg ttagtacagt tttgctgaaa ggttattgtt
      541 gtgtttgtca agacagaaga aaaagcaaac gaattatctt tggaaatatc tttgcagtat
      601 cagaagagat tagttagtaa ggcaatacgc ttttccgcag taatggtatt cttttaaatt
      661 atgaatccat ctctaaaggt tacatagaaa cttgaaggag agaggaacat tcagttaaga
      721 tagtctaggt ttttctactg aagcagcaat tacaggagaa agagctctac agtagttttc
      781 aactttctgt ctgcagtcat tagtaaaaat gaaaaggtaa aatttaactg attttataga
      841 ttcaaataat tttcctttta ggatggattc tttaaaactc ctaatattta tcaaatgctt
      901 atttaagtgt cacacacagt taagaaattt gtacaccttg tctcctttaa ttctcataac
      961 aactccataa aatgggtcct aggatttcca tttgaagata agaaacctga agcttgccga
     1021 agccctgtgt ctgctctcct taatctctgt gagagtgcca tctcttcctg gggacttgta
     1081 ggcatgccac tgtctcctct tctggctaac attgctgttg ctctcttttg tgtatgtgaa
     1141 tgaatcttta aagactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt
     1201 gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt
     1261 ctgctctgat gaagactggg taagcagtca gcgggggaag caggagattc cttccctctg
     1321 atgctagagg ggctcacagg ctgacctgat tggtcccaga aactttttta aatagaaaat
     1381 aattgaatag ttacctacat agcaaataaa gaaaaggaac ctactcccaa gagcactgtt
     1441 tatttacctc cccaactctg gatcattagt gggtgaacag acaggatttc agttgcatgc
     1501 tcaggcaaaa ccaggctcct gagtattgtg gcctcaattt cctggcacct atttatggct
     1561 aagtggaccc tcattccaga gtttctctgc gacctctaac tagtcctctt acctactttt
     1621 aagccaactt atctggaaga gaaagggtag gaagaaatgg gggctgcatg gaaacatgca
     1681 aaattattct gaatctgaga gatagatcct tactgtaatt ttctcccttc actttcagaa
     1741 ctacaaatgc ccttctggct gcaggatgaa agggttgatt gatgaagtca atcaagattt
     1801 tacaaacaga ataaataagc tcaaaaattc actatttgaa tatcagaaga acaataagga
     1861 ttctcattcg ttgaccacta atataatgga aattttgaga ggcgattttt cctcagccaa
     1921 tagtaagtat tacatattta cttctttgac tttataacag aaacaacaaa aatcctaaat
     1981 aaatatgata tccgcttata tctatgacaa tttcatccca aagtacttag tgtagaaaca
     2041 cataccttca taatatccct gaaaatttta agagggagct tttgttttcg ttattttttc
     2101 aaagtaaaag atgttaactg agattgttta aggtcacaaa ataagtcaga attttggatt
     2161 aaaacaagaa tttaaatgtg ttcttttcaa cagtatatac tgaaagtagg atgggtcaga
     2221 ctctttgagt tgatattttt gtttctgctt tgtaaaggtg aaaactgaga ggtcaaggaa
     2281 cttgttcaaa gacacagagc tgggaattca actcccagac tccactgagc tgattaggta
     2341 gatttttaaa tttaaaatat agggtcaagc tacgtcattc tcacagtcta ctcattaggg
     2401 ttaggaaaca ttgcattcac tctgggcatg gacagcgagt ctagggagtc ctcagtttct
     2461 caagttttgc tttgcctttt tacaccttca caaacacttg acatttaaaa tcagtgatgc
     2521 caacactagc tggcaagtga gtgatcctgt tgacccaaaa cagcttagga accatttcaa
     2581 atctatagag ttaaaaagaa aagctcatca gtaagaaaat ccaatatgtt caagtccctt
     2641 gattaaggat gttataaaat aattgaaatg caatcaaacc aactatttta actccaaatt
     2701 acacctttaa aattccaaag aaagttcttc ttctatattt ctttgggatt actaattgct
     2761 attaggacat cttaactggc attcatggaa ggctgcaggg cataacatta tccaaaagtc
     2821 aaatgcccca taggttttga actcacagat taaactgtaa ccaaaataaa attaggcata
     2881 tttacaagct agtttctttc tttctttttt ctctttcttt ctttctttct ttctttcttt
     2941 ctttctttct ttctttcttt ctttctcctt ccttcctttc ttcctttctt ttttgctggc
     3001 aattacagac aaatcactca gcagctactt caataaccat attttcgatt tcagaccgtg
     3061 ataataccta caaccgagtg tcagaggatc tgagaagcag aattgaagtc ctgaagcgca
     3121 aagtcataga aaaagtacag catatccagc ttctgcagaa aaatgttaga gctcagttgg
     3181 ttgatatgaa acgactggag gtaagtatgt ggctgtggtc ccgagtgtcc ttgtttttga
     3241 gtagagggaa aaggaaggcg atagttatgc actgagtgtc tactatatgc agagaaaagt
     3301 gttatatcca tcatctacct aaaagtaggt attattttcc tcactccaca gttgaagaaa
     3361 aaaaaattca gagatattaa gtaaattttc caacgtacat agatagtaat tcaaagcaat
     3421 gttcagtccc tgtctattcc aagccattac atcaccacac ctctgagccc tcagcctgag
     3481 ttcaccaagg atcatttaat tagcgtttcc tttgagaggg aatagcacct tactcttgat
     3541 ccattctgag gctaagatga attaaacagc atccattgct tatcctggct agccctgcaa
     3601 tacccaacat ctcttccact gagggtgctc gataggcaga aaacagagaa tattaagtgg
     3661 taggtctccg agtcaaaaaa aatgaaacca gtttccagaa ggaaaattaa ctaccaggaa
     3721 ctcaatagac gtagtttatg tatttgtatc tacattttct ctttattttt ctcccctctc
     3781 tctaggtgga cattgatatt aagatccgat cttgtcgagg gtcatgcagt agggctttag
     3841 ctcgtgaagt agatctgaag gactatgaag atcagcagaa gcaacttgaa caggtcattg
     3901 ccaaagactt acttccctct agagataggc aacacttacc actgataaaa atgaaaccag
     3961 ttccagactt ggttcccgga aattttaaga gccagcttca gaaggtaccc ccagagtgga
     4021 aggcattaac agacatgccg cagatgagaa tggagttaga gagacctggt ggaaatgaga
     4081 ttactcgagg aggctccacc tcttatggaa ccggatcaga gacggaaagc cccaggaacc
     4141 ctagcagtgc tggaagctgg aactctggga gctctggacc tggaagtact ggaaaccgaa
     4201 accctgggag ctctgggact ggagggactg caacctggaa acctgggagc tctggacctg
     4261 gaagtgctgg aagctggaac tctgggagct ctggaactgg aagtactgga aaccaaaacc
     4321 ctgggagccc tagacctggt agtaccggaa cctggaatcc tggcagctct gaacgcggaa
     4381 gtgctgggca ctggacctct gagagctctg tatctggtag tactggacaa tggcactctg
     4441 aatctggaag ttttaggcca gatagcccag gctctgggaa cgcgaggcct aacaacccag
     4501 actggggcac atttgaagag gtgtcaggaa atgtaagtcc agggacaagg agagagtacc
     4561 acacagaaaa actggtcact tctaaaggag ataaagagct caggactggt aaagagaagg
     4621 tcacctctgg tagcacaacc accacgcgtc gttcatgctc taaaaccgtt actaagactg
     4681 ttattggtcc tgatggtcac aaagaagtta ccaaagaagt ggtgacctcc gaagatggtt
     4741 ctgactgtcc cgaggcaatg gatttaggca cattgtctgg cataggtact ctggatgggt
     4801 tccgccatag gcaccctgat gaagctgcct tcttcgacac tgcctcaact ggaaaaacat
     4861 tcccaggttt cttctcacct atgttaggag agtttgtcag tgagactgag tctaggggct
     4921 cagaatctgg catcttcaca aatacaaagg aatccagttc tcatcaccct gggatagctg
     4981 aattcccttc ccgtggtaaa tcttcaagtt acagcaaaca atttactagt agcacgagtt
     5041 acaacagagg agactccaca tttgaaagca agagctataa aatggcagat gaggccggaa
     5101 gtgaagccga tcatgaagga acacatagca ccaagagagg ccatgctaaa tctcgccctg
     5161 tcagaggtat ccacacttct cctttgggga agccttccct gtccccctag actaagttaa
     5221 atatttctgc acagtgttcc catggcccct tgcatttcct tcttaactct ctgttacacg
     5281 tcattgaaac tacacttttt tggtctgttt ttgtgctaga ctgtaagttc cttgggggca
     5341 gggcctttgt ctgtctcatc tctgtattcc caaatgccta acagtacaga gccatgactc
     5401 aataaataca tgttaaatgg atgaatgaat tcctctgaaa ctctatttga gcttatttag
     5461 tcaaattctt tcactattca aagtgtgtgc tattagaatt gtcacccaac tgattaatca
     5521 catttttagt atgtgtctca gttgacattt aggtcaggct aaatacaagt tgtgttagta
     5581 ttaagtgagc ttagctacct gtactggtta cttgctatta gtttgtgcaa gtaaaattcc
     5641 aaatacattt gaggaaaatc ccctttgcaa tttgtaggta taaataaccg cttatttgca
     5701 taagttctat cccactgtaa gtgcatcctt tccctatgga gggaaggaaa ggaggaagaa
     5761 agaaaggaag ggaaagaaac agtatttgcc ttatttaatc tgagccgtgc ctatctttgt
     5821 aaagttaaat gagaataact tcttccaacc agcttaattt tttttttaga ctgtgatgat
     5881 gtcctccaaa cacatccttc aggtacccaa agtggcattt tcaatatcaa gctatccgga
     5941 tcc
//