From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human cathepsin S (catS) mRNA, complete cds.
Date: 28 Jul 92 10:03:01 GMT
Distribution: bionet
Checksum: 62165     5

LOCUS       HUMCATS      1784 bp ss-mRNA            PRI       28-JUL-1992
DEFINITION  Human cathepsin S (catS) mRNA, complete cds.
ACCESSION   M90696
KEYWORDS    cathepsin S; cysteine proteinase; lysosomal enzyme.
SOURCE      Homo sapiens (library: lambda gt11 (Clontech #HL10106)) testis cDNA
            to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Ritonja,A., Colic,A., Dolenc,I., Ogrinc,T., Podobnik,M. and Turk,V.
  TITLE     The complete amino acid sequence of bovine cathepsin S and a
            partial sequence of bovine cathepsin L.
  JOURNAL   FEBS Lett. 283, 329-331 (1991)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 1784)
  AUTHORS   Wiederanders,B., Broemme,D., Kirschke,H., Figura,K.V., Schmidt,B.
            and Peters,C.
  TITLE     Phylogenetic conservation of cysteine proteinases: Cloning and
            expression of a cDNA coding for human cathepsin S
  JOURNAL   J. Biol. Chem. 267, 13708-13713 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             158..1153
                     /product="cathepsin S"
                     /gene="catS"
                     /codon_start=1
                     /translation="MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNE
                     EAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQ
                     RNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLV
                     SLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDLKCQYDSK
                     YRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNV
                     NHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI"
     sig_peptide     158..499
                     /gene="catS"
                     /codon_start=1
     mat_peptide     500..1150
                     /product="cathepsin S"
                     /gene="catS"
                     /codon_start=1
BASE COUNT      532 a    349 c    403 g    500 t
ORIGIN
        1 tatgaccatg attacgaatt cggggtacct catgtgacaa gttccaattt cttttcaagt
       61 caattgaact gaaatctcct tgttgctttg aaatcttaga agagagccca ctaattcaag
      121 gactcttact gtaggagcaa ctgctggttc tatcacaatg aaacggctgg tttgtgtgct
      181 cttggtgtgc tcctctgcag tggcacagtt gcataaagat cctaccctgg atcaccactg
      241 gcatctctgg aagaaaacct atggcaaaca atacaaggaa aagaatgaag aagcagtacg
      301 acgtctcatc tgggaaaaga atctaaagtt tgtgatgctt cacaacctgg agcattcaat
      361 gggaatgcac tcatacgatc tgggcatgaa ccacctggga gacatgacca gtgaagaagt
      421 gatgtctttg atgagttccc tgagagttcc cagccagtgg cagagaaata tcacatataa
      481 gtcaaaccct aatcggatat tgcctgattc tgtggactgg agagagaaag ggtgtgttac
      541 tgaagtgaaa tatcaaggtt cttgtggtgc ttgctgggct ttcagtgctg tgggggccct
      601 ggaagcacag ctgaagctga aaacaggaaa gctggtgtct ctcagtgccc agaacctggt
      661 ggattgctca actgaaaaat atggaaacaa aggctgcaat ggtggcttca tgacaacggc
      721 tttccagtac atcattgata acaagggcat cgactcagac gcttcctatc cctacaaagc
      781 catggatctg aaatgtcaat atgactcaaa atatcgtgct gccacatgtt caaagtacac
      841 tgaacttcct tatggcagag aagatgtcct gaaagaagct gtggccaata aaggcccagt
      901 gtctgttggt gtagatgcgc gtcatccttc tttcttcctc tacagaagtg gtgtctacta
      961 tgaaccatcc tgtactcaga atgtgaatca tggtgtactt gtggttggct atggtgatct
     1021 taatgggaaa gaatactggc ttgtgaaaaa cagctggggc cacaactttg gtgaagaagg
     1081 atatattcgg atggcaagaa ataaaggaaa tcattgtggg attgctagct ttccctctta
     1141 cccagaaatc tagaggatct ctccttttta taacaaatca atgaaatatg aagcactttc
     1201 tcttaactta atttttcctg ctgtatccag aagaaataat tgtgtcatga ttaatgtgta
     1261 tttactgtac taattagaaa atatagtttg aggccgggca cgtggctcac gcgtaatccc
     1321 gttacttggg aggccaaggc aggcattatc aatcttgagg ccaggagtta aagagcagcc
     1381 tggctaacat ggtgaaaccc catctctact aaaaatacaa aaaattagcc gagcacggtg
     1441 gtgcatgcct gtaatcccag ctacttggga ggctgaggca cgagattcct tgaacccaag
     1501 aggttgaggc tatgttgagc tgagatcaca ccactgtact ccagcctgga tgacagagtg
     1561 gagactctgt ttcaaaaaaa cagaaaagaa aatatagttt gattcttcat ttttttaaat
     1621 ttgcaaatct caggataaag tttgctaagt aaattagtaa tgtactatag atataactgt
     1681 acaaaaattg ttcaacctaa aacaatctgt aattgcttat tgttttattg tcccgaattc
     1741 agttggttta atatattgtc ctctgtaatt tcgatccttc ttaa
//