From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human ornithine decarboxylase (ODC) gene, complete cds.
Date: 31 Jul 92 10:01:27 GMT
Distribution: bionet
Checksum: 50415    10

LOCUS       HUMODCA2     5367 bp ds-DNA             PRI       31-JUL-1992
DEFINITION  Human ornithine decarboxylase (ODC) gene, complete cds.
ACCESSION   M34158 J05271
KEYWORDS    ornithine decarboxylase.
SEGMENT     2 of 2
SOURCE      Human leukocyte DNA, clone ODC709-A2.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 5367)
  AUTHORS   Moshier,J.A., Gilbert,J.D., Skunca,M., Dosescu,J., Almodovar,K.M.
            and Luk,G.D.
  TITLE     Isolation and expression of a human ornithine decarboxylase gene
  JOURNAL   J. Biol. Chem. 265, 4884-4892 (1990)
  STANDARD  simple staff_review
FEATURES             Location/Qualifiers
     prim_transcript <1..5137
                     /note="ODC1 mRNA and introns"
     intron          <1..274
                     /note="ODC1 intron A"
     CDS             join(507..608,892..1065,1272..1444,1703..1837,1968..2049,
                     2226..2309,3365..3527,3610..3722,3816..4030,4671..4814)
                     /product="ornithine decarboxylase"
                     /gene="ODC1"
                     /codon_start=1
                     /translation="MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVAD
                     LGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLG
                     VPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDS
                     KAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCV
                     FDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPG
                     RYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHA
                     HVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVA
                     AASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRH
                     RAACASASINV"
                     /partial
     exon            507..608
                     /gene="ODC1"
                     /partial
     intron          609..891
                     /note="ODC1 intron B"
     exon            892..1065
                     /number=2
     intron          1066..1271
                     /note="ODC1 intron C"
     exon            1272..1444
                     /number=3
     intron          1445..1702
                     /note="ODC1 intron D"
     exon            1703..1837
                     /number=4
     intron          1838..1967
                     /note="ODC1 intron E"
     exon            1968..2049
                     /number=5
     intron          2050..2225
                     /note="ODC1 intron F"
     exon            2226..2309
                     /number=6
     intron          2310..3364
                     /note="ODC1 intron G"
     exon            3365..3527
                     /number=7
     intron          3528..3609
                     /note="ODC1 intron H"
     exon            3610..3722
                     /number=8
     intron          3723..3815
                     /note="ODC1 intron I"
     exon            3816..4030
                     /number=9
     intron          4031..4670
                     /note="ODC1 intron K"
     exon            4671..>4815
                     /number=10
BASE COUNT     1443 a   1023 c   1270 g   1630 t      1 others
ORIGIN      Chromosome 2pter-p23.
        1 aagcttctga aacttgcatg ctagattttt ttggtacaaa tatttgaaat gcttagtgtg
       61 ctgccttgga aaaacctggt attttttgtt gtgtccttat actgccaagg tttatggaat
      121 catgtacctt atgcctagta ataattagga tgaccaggcc agtgagtggt tcatatccgg
      181 ggcatgatta gctctgcgtg tgctcagcca gtgccccatc ttcaactcga tgtgttccta
      241 aggtagacag caaattccct attttatttc tcagattgtc actgctgttc caagggcaca
      301 cgcagaggga tttggaattc ctggagagtt gcctttgtga gaagctggaa atagttcttt
      361 caattccatc tcttagtttt ccatgtaagt attcagttta catttatgtt gcaggttaat
      421 cttaagaatt gtattgctaa ggcttctaag tgaatttctc cactctattt gcattttgtt
      481 gcatttcaga ggaacatcaa gaaatcatga acaactttgg taatgaagag tttgactgcc
      541 acttcctcga tgaaggtttt actgccaagg acattctgga ccagaaaatt aatgaagttt
      601 cttcttctgt aagtatatga ggcccatgct ggcagtgcag ctgagagtgc caggcaagtg
      661 gaaaactttg gcaaggtcta aggaagagca gtgaggctta catgtcttgt tatggaataa
      721 attaattcac tggtggtaaa ttaatagtga taatggtgat actcatatca gtggctagac
      781 tcaaaagagg tagcaggatt cattgtgact gatgggaatg aaggtcgctg gctattggtg
      841 tggtgtgtgg tgaggctgct agtgagtcac ctgtgaccac tcttgtttca ggatgataag
      901 gatgccttct atgtggcaga cctgggagac attctaaaga aacatctgag gtggttaaaa
      961 gctctccctc gtgtcacccc cttttatgca gtcaaatgta atgatagcaa agccatcgtg
     1021 aagacccttg ctgctaccgg gacaggattt gactgtgcta gcaaggtaag cgatagcagc
     1081 aggcctcaaa agcgttgtat aaaatgggcc tggtattccc cacgaggcag atacaagttg
     1141 tgttttttgg gcaataaatg ctcactaaag gcaaatgggg cgggggggta catgacaact
     1201 tcccatgctt ttctgtttat tccacgtgtt aagccacata tggatagcat gacaccactc
     1261 ttctttttca gactgaaata cagttggtgc agagtctggg ggtgcctcca gagaggatta
     1321 tctatgcaaa tccttgtaaa caagtatctc aaattaagta tgctgctaat aatggagtcc
     1381 agatgatgac ttttgatagt gaagttgagt tgatgaaagt tgccagagca catcccaaag
     1441 caaagtgagt tattccccca tctgagggca agatcgggag cataagatat gtggattctt
     1501 atcaaacaaa cttaaatttc tgattattat atttctatac tttagtagaa agtagttgaa
     1561 acccccattg agtcatgaag cctgggactc aaactacagn atatatcagc gacagtattt
     1621 agaacaggat tgtttttatt ttgattgtgg ctataagtga acatctatca tgagacattt
     1681 gctgcacttt ccttgcttgt aggttggttt tgcggattgc cactgatgat tccaaagcag
     1741 tctgtcgtct cagtgtgaaa ttcggtgcca cgctcagaac cagcaggctc cttttggaac
     1801 gggcgaaaga gctaaatatc gatgttgttg gtgtcaggtg agattttggt gggatagcta
     1861 gaggtcaaga cattgaacag tttgagtttt acaggctttc tcctagtgtt tgctattatt
     1921 ttaagaaata ctaagacaca gtgtctcgtc tctttatttt accccagctt ccatgtagga
     1981 agcggctgta ccgatcctga gaccttcgtg caggcaatct ctgatgcccg ctgtgttttt
     2041 gacatggggg tgagtatacg tgaccctgtt agggaagggc gggacacaac tgacaataac
     2101 tagtcttaat tctagagtta actttttatg gcagttggtt ctgtattaca tgggtttcag
     2161 cctatctgct gcatacattt ttgttattag ctgtggatct ggctgactta ttttcttgat
     2221 tctaggctga ggttggtttc agcatgtatc tgcttgatat tggcggtggc tttcctggat
     2281 ctgaggatgt gaaacttaaa tttgaagagg taatttagaa caaaactgta atactcagta
     2341 gccgttctaa taaattcctt tttggaatat ttcaaaattt aagtgtctta actaatacca
     2401 caatgggctg aagtgtcttg gtgtgatatt ttgagtgatt tctttgtgct gtctgacatt
     2461 acacttgata ccatttggtt ttctaaagtg tgaatcagct ttcccagaag tcttggataa
     2521 ttggttacat tggaaatcat ggctcacacc tgtaatccag cacttgggga ggccaaggtg
     2581 gtaggatcac ttgagcccag gagtttgaga ccagcctggg caacacagtg agaccccatc
     2641 tctacaaaaa aaattttaaa attagcctgg tgtggtggcg ggcacctgta atcccagcta
     2701 cttggaaggc tgaggtggga ggatcacttg agcccaggag gttgaggctg cagtgagcca
     2761 tgatcatgcc actgcactca gcctgggcta cagagtgaga ccctgtctca aaaaaaaaaa
     2821 agaaaaagca tgttgctgtg ggcttcctag agaatatgct gactgtagca catcatcacc
     2881 ccaaatgtgc tttgctagac ctatgcttcc tctccttaaa atacttgaaa tgtttagtca
     2941 cttaggaagt taagccatta tattggtgct tgaatttata aaatacatcc acatggtttg
     3001 ttaaaatcat gacgtaggca gaataggatt tttatcctgt tggcatgtat ttgttaaaat
     3061 gttttgacat cttgatgcct tcctaggtag tagttagttg cgtactgttc tttgataaaa
     3121 atcatgccca taacatccta aaggagatag ggtgcctgga ggggaatgaa aacgagccac
     3181 ctgggatatg tagcctggtt ttcagggaga tgttgatgtt tttttgcttt tgttacttta
     3241 atgataaacc tgtctgttga tgcctggtct catgatgtca tgtcacaagg ccctgtgatg
     3301 ttactccccc atgtgaattt cccacaatga aggctgctct ttcttttctg tttcactctc
     3361 ttagatcacc ggcgtaatca acccagcgtt ggacaaatac tttccgtcag actctggagt
     3421 gagaatcata gctgagcccg gcagatacta tgttgcatca gctttcacgc ttgcagttaa
     3481 tatcattgcc aagaaaattg tattaaagga acagacgggc tctgatggta tgtataaagg
     3541 acgaatcact tcatgtataa ctgaaagctg atgcaaaaag tcattaagat tgttgatctg
     3601 cctttctaga cgaagatgag tcgagtgagc agacctttat gtattatgtg aatgatggcg
     3661 tctatggatc atttaattgc atactctatg accacgcaca tgtaaagccc cttctgcaaa
     3721 aggtaatttc tgagcatact gtataaaaca attaagagga ctggtcacaa cacgtgtaat
     3781 taagtagtac ttcctctctc cgtctcttta tatagagacc taaaccagat gagaagtatt
     3841 attcatccag catatgggga ccaacatgtg atggcctcga tcggattgtt gagcgctgtg
     3901 acctgcctga aatgcatgtg ggtgattgga tgctctttga aaacatgggc gcttacactg
     3961 ttgctgctgc ctctacgttc aatggcttcc agaggccgac gatctactat gtgatgtcag
     4021 ggcctgcgtg gtaagtaagc catgcatgtt gatggtgctg ccaagaatag gcaccttctt
     4081 ggatgtgtgc ttcttgtcta gacgaataag aaattgtctt gcctaagatt aaatatatat
     4141 ggatattttt cctaagaaaa gttttagaaa agactgatga gtgtatttct atgtaattgg
     4201 aatatattta agttcatgcc atgtgtcttg tggtttcctt attaccaaaa cggtgactga
     4261 agaaacgctt gctttagaaa tacattgaat tggccaggtg tgctggctca cacctgaaat
     4321 cacaacacat tgggaggcca aggcagaagg atcacttgag cccaggagtt cgagcctggg
     4381 caacatagtg agaccctgtc tctacaaaaa attaaaaaat tagttggcca tggtagtggg
     4441 cgcctgtagt cccagctgct tggctaaggt gagaggtttg cttgagcctg ggaggttgag
     4501 gctgcggtga gctatgatag caccattgta ttccagcctg agtaacagag aaagaccctg
     4561 tctcagaaaa aaaaaaaata cattgaattg tttcctgatg ggaagtaaat actctcatgc
     4621 ccagttagga gtgagtcagg gtttttaata tgccactttt tctttctcag gcaactcatg
     4681 cagcaattcc agaaccctga cttcccaccc gaagtagagg aacaggatgc cagcaccctg
     4741 cctgtgtctt gtgcctggga gagtgggatg aaacgccaca gagcagcctg tgcttcggct
     4801 agtattaatg tgtagatagc actctggtag ctgttaactg caagtttagc ttgaattaag
     4861 ggatttgggg ggaccatgta acttaattac tgctagtttt gaaatgtctt tgtaagagta
     4921 gggtcgccat gatgcagcca tatggaagac taggatatgg gtcacactta tctgtgttcc
     4981 tatggaaact atttgaatat ttgttttata tggattttta ttcactcttc agacacgcta
     5041 ctcaagagtg cccctcagct gctgaacaag catttgtagc ttgtacaatg gcagaatggg
     5101 ccaaaagctt agtgttgtga cctgttttta aaataaagta tcttgaaata attaggcatt
     5161 gggacgtttt tatggtgtgt tcattccaga cagttcacga atcccgtata gctcgctctg
     5221 attctcagag aacaatgagt gggtccaccc acacacaggt aggaggacag gtgagacgga
     5281 agccccatcc tcccatgtgg acggtgcaca tctgctcagc ccaccccaca tgtgcagagt
     5341 tggctgcaaa ctccttgtcc agagcct
//