From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human T-cell membrane glycoprotein CD28 mRNA, exon 4.
Date: 22 Jul 92 10:02:55 GMT
Distribution: bionet
Checksum: 39745     7

LOCUS       HUMCD284     3230 bp ds-DNA             PRI       22-JUL-1992
DEFINITION  Human T-cell membrane glycoprotein CD28 mRNA, exon 4.
ACCESSION   M37815
KEYWORDS    glycoprotein CD28.
SEGMENT     4 of 4
SOURCE      Human DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Lee,K.P., Taylor,C., Petryniak,B., Turka,L.A., June,C.H. and
            Thompson,C.B.
  TITLE     The genomic organization of the CD28 gene: Implications for the
            regulation of CD28 mRNA expression and heterogeneity
  JOURNAL   J. Immunol. 145, 344-352 (1990)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     intron          order(M37814:252..467,1..121)
                     /number=3
                     /note="number 3"
                     /gene="CD28"
     mRNA            join(M37812:539..812,M37813:65..421,M37814:127..251,
                     122..1003)
                     /gene="CD28"
     mRNA            join(M37812:539..812,M37813:65..421,M37814:127..251,
                     122..3169)
                     /product="glycoprotein CD28"
                     /gene="CD28"
     CDS             join(M37812:761..812,M37813:65..421,M37814:127..251,
                     122..250)
                     /product="glycoprotein CD28"
                     /codon_start=1
                     /translation="MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSY
                     NLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNL
                     YVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVG
                     GVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAY
                     RS"
     CDS             join(M37812:761..812,M37813:65..130,M37813:383..421,
                     M37814:127..251,122..250)
                     /note="deleted form"
                     /product="glycoprotein CD28"
                     /gene="CD28"
                     /codon_start=1
                     /translation="MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSYNEKS
                     NGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRL
                     LHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS"
     exon            122..1003
                     /number=4
                     /note="number 4"
     exon            122..3169
                     /number=4
                     /note="number 4"
     polyA_signal    991..996
                     /gene="CD28"
     repeat_unit     1074..1357
                     /rpt_family="Alu"
BASE COUNT      941 a    630 c    717 g    942 t
ORIGIN
        1 aaaggttagt gttttagtgt ctctgtcatt tgacagttaa tattatgaat agttgtgccc
       61 acagtcttag aactccttcc atgacattgt ccctccatac tgacacttct ctttcctgca
      121 ggtgaggagt aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg
      181 ccccgggccc acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta
      241 tcgctcctga cacggacgcc tatccagaag ccagccggct ggcagccccc atctgctcaa
      301 tatcactgct ctggatagga aatgaccgcc atctccagcc ggccacctca ggcccctgtt
      361 gggccaccaa tgccaatttt tctcgagtga ctagaccaaa tatcaagatc attttgagac
      421 tctgaaatga agtaaaagag atttcctgtg acaggccaag tcttacagtg ccatggccca
      481 cattccaact taccatgtac ttagtgactt gactgagaag ttagggtaga aaacaaaaag
      541 ggagtggatt ctgggagcct cttccctttc tcactcacct gcacatctca gtcaagcaaa
      601 gtgtggtatc cacagacatt ttagttgcag aagaaaggct aggaaatcat tccttttggt
      661 taaatgggtg tttaatcttt tggttagtgg gttaaacggg gtaagttaga gtagggggag
      721 ggataggaag acatatttaa aaaccattaa aacactgtct cccactcatg aaatgagcca
      781 cgtagttcct atttaatgct gttttccttt agtttagaaa tacatagaca ttgtctttta
      841 tgaattctga tcatatttag tcattttgac caaatgaggg atttggtcaa atgagggatt
      901 ccctcaaagc aatatcaggt aaaccaagtt gctttcctca ctccctgtca tgagacttca
      961 gtgttaatgt tcacaatata ctttcgaaag aataaaatag ttctcctaca tgaagaaaga
     1021 atatgtcagg aaataaggtc actttatgtc aaaattattt gagtactatg ggacctggcg
     1081 cagtggctca tgcttgtaat cccagcactt tgggaggccg aggtgggcag atcacttgag
     1141 atcaggacca gcctggtcaa gatggtgaaa ctccgtctgt actaaaaata caaaatttag
     1201 cttggcctgg tggcaggcac ctgtaatccc agctgcccag gaggctgagg catgagaatc
     1261 gcttgaacct ggcaggcgga ggttgcagtg agccgagata gtgccacagc tctccagcct
     1321 gggcgacaga gtgagactcc atctcaaaca acaacaacaa caacaacaac aacaacaaac
     1381 cacaaaatta tttgagtact gtgaaggatt atttgtctaa cagttcattc caatcagacc
     1441 aggtaggagc tttcctgttt catatgtttc agggttgcac agttggtctc tttaatgtcg
     1501 gtgtggagat ccaaagtggg ttgtggaaag agcgtccata ggagaagtga gaatactgtg
     1561 aaaagggatg ttagcattca ttagagtatg aggatgagtc ccaagaaggt tctttggaag
     1621 gaggacgaat agaatggagt aatgaaattc ttgccatgtg ctgaggagat agccagcatt
     1681 aggtgacaat cttccagaag tggtcaggca gaaggtgccc tggtgagagc tcctttacag
     1741 ggactttatg tggtttaggg ctcagagctc caaaactctg ggctcagctg ctcctgtacc
     1801 ttggaggtcc attcacatgg gaaagtattt tggaatgtgt cttttgaaga gagcatcaga
     1861 gttcttaagg gactgggtaa ggcctgaccc tgaaatgacc atggatattt ttctacctac
     1921 agtttgagtc aactagaata tgcctgggga ccttgaagaa tgcccttcag tggccctcac
     1981 catttgttca tgcttcagtt aattcaggtg ttgaaggagc ttaggtttta gaggcacgta
     2041 gacttggttc aagtctcgtt agtagttgaa tagcctcagg caagtcactg cccacctaag
     2101 atgatggttc ttcaactata aatggagata atggttacaa atgtctcttc ctatagtata
     2161 atctccataa gggcatggcc caagtctgtc tttgactctg cctatccctg acgtttagta
     2221 gcatgcccga catacaatgt tagctattgg tattattgcc atatagataa attatgtata
     2281 aaaattaaac tgggcaatag cctaagaagg ggggaatatt gtaacacaaa tttaaaccca
     2341 ctacgcaggg atgaggtgct ataatatgag gaccttttaa cttccatcat tttcctgttt
     2401 cttgaaatag tttatcttgt aatgaaatat aaggcacctc ccacttttat gtatagaaag
     2461 aggtctttta attttttttt aatgtgagaa ggaagggagg agtaggaatc ttgagattcc
     2521 atatcgaaaa tactgtactt tggttgattt ttaagtgggc ttccattcca tggatttaat
     2581 cagtcccaag aagatcaaac tcagcagtac ttgggtgctg aagaactgtt ggatttaccc
     2641 tggcacgtgt gccacttgcc cagcttcttg ggcacacaga gttcttcaat ccaagttatc
     2701 agattgtatt tgaaaatgac agagctggag agttttttga aatggcagtg gcaaataaat
     2761 aaatactttt ttttaaatgg aaagacttga tctatggtaa taaatgattt tgttttctga
     2821 ctggaaaaat aggcctacta aagatgaatc acacttgaga tgtttcttac tcactctgca
     2881 cagaaacaaa gaagaaatgt tatacaggga agtccgtttt cactattagt atgaaccaag
     2941 aaatggttca aaaacagtgg taggagcaat gctttcatag tttcagatat ggtagttatg
     3001 aagaaaacaa tgtcatttgc tgctattatt gtaagagtct tataattaat ggtactccta
     3061 taatttttga ttgtgagctc acctatttgg gttaagcatg ccaatttaaa gagaccaagt
     3121 gtatgtacat tatgttctac atattcagtg ataaaattac taaactacta tatgtctgct
     3181 ttaaatttgt actttaatat tgtcttttgg tattaagaaa gatatgcttt
//