From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Drosophila melanogaster calcium activated potassium channel
Date: 29 Sep 92 10:02:57 GMT
Distribution: bionet
Checksum: 56722    10

LOCUS       DROKCHAN     4415 bp ss-mRNA            INV       29-SEP-1992
DEFINITION  Drosophila melanogaster calcium activated potassium channel
            (slowpoke) mRNA, complete cds.
ACCESSION   M96840
KEYWORDS    alternative splicing; calcium activated potassium channel.
SOURCE      Drosophila melanogaster (strain Canton S) (library: lambda gt11
            cDNA) adult head cDNA to mRNA.
  ORGANISM  Drosophila melanogaster
            Eukaryota; Animalia; Metazoa; Arthropoda; Uniramia; Insecta;
            Pterygota; Neoptera; Holometabola; Diptera; Brachycera;
            Cyclorrhapha; Schizophora; Drosophiloidea; Drosophilidae.
REFERENCE   1  (sites)
  AUTHORS   Atkinson,N.S., Robertson,G.A. and Ganetzky,B.
  TITLE     A component of calcium-activated potassium channels encoded by the
            Drosophila slo locus
  JOURNAL   Science 253, 551-555 (1991)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 4415)
  AUTHORS   Adelman,J.P., Shen,K.-Z., Kavanaugh,M.P., Warren,R.A., Wu,Y.-N.,
            Lagrutta,A., Bond,C.T. and North,R.A.
  TITLE     Calcium-activated potassium channels expressed from cloned
            complementary DNAs
  JOURNAL   Neuron 9, 209-216 (1992)
  STANDARD  unannotated staff_entry
FEATURES             Location/Qualifiers
     CDS             516..4043
                     /product="calcium activated potassium channel"
                     /gene="slowpoke"
                     /note="putative"
                     /codon_start=1
                     /translation="MASGLIDTNFSSTLANGMSGCDQSTVESLADDPTDSPFDADDCL
                     KVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCCRKEPDLGPNDPKQKEQKASRNKQE
                     FEGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWS
                     NNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTW
                     IGLRFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGD
                     PLDFDNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAMFASSIP
                     EIIELVGSGNKYGGELKREHGKRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFL
                     HRKPPDLELEGLFKRHFTTVEFFQGTIMNPIDLQRVKVHEADACLVLANKYCQDPDAE
                     DAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFI
                     AQSCLAPGFSTMMANLFAMRSFKTSPDMQSWTNDYLRGTGMEMYTETLSPTFIGIPFA
                     QATELCFSKLKLLLLAIEIKGAEEGADSKISINPRGAKIQANTQGFFIAQSADEVKRA
                     WFYCKACHEDIKDETLIKKCKCKNLTVQPRSKFDDLGDITRDREDTNLLNRNVRRPNG
                     TGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQVISPSQYNRPTSRS
                     SGTGTQNQNGGVSLPAGIADDQSKDFDFEKTEMKYDSTGMFHWSPAKSLEDCILDRNQ
                     AAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREW
                     KMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASL
                     NIKAMTFDDTIGVLSQRGPEFDNLSATAGSPIVLQRRGSVYGANVPMITELVNDGNVQ
                     FLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATP
                     ELELILAEGAGLRGGYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALK
                     SYGMLCIGLYRFRDTSSSCDASSKRYVITNPPDDFSLLPTDQVFVLMQFDPGLEYKPP
                     AVRAPAGGRGTNTQGSGVGGGGSNKDDNS"
     exon            1494..1583
                     /note="this span from alternative exon A1"
                     /gene="slowpoke"
     exon            1695..1799
                     /note="this span from alternative exon C2"
                     /gene="slowpoke"
     exon            2111..2222
                     /note="this span from alternative exon E2"
                     /gene="slowpoke"
     exon            2460..2525
                     /note="this span from alternative exon G5"
                     /gene="slowpoke"
     misc_feature    2720
                     /note="insertion site for exon I"
                     /gene="slowpoke"
BASE COUNT     1118 a   1061 c   1151 g   1085 t
ORIGIN
        1 gaattcctca catgcgtatg tgcagtgatt caccgaatga gtgcgttgcc tctggccgca
       61 agttgtgaat acccagtgaa tccctaatga atgcaggcca taaccacaat cctaaccaga
      121 ttgtagtata tgtatatatg tagttatggt atttggttgt atggatcgta agatcggtgc
      181 tgtgtagtcg gcctttgccc agtgttatga gcacttttgt cgccgtgcgt gtgtcggaga
      241 aaaagatcac tttaaaaata acagatttgt ttgatgctat ttataataga cgggccaagt
      301 tttcgttccg tttcgcattg tgaggctgag gcctttggtg ttccgagatc tcggtggttc
      361 attcgtatct ttcggatttc ccagcgtctt ctattctctg gcactctagt agcctggcac
      421 tcgactgcac ttgaacgcca ttcgaatacg aatatcgtgg caatattaat ttgacagcgt
      481 ttgtgtgttc gagtgtcgca atgtaaacag ccaaaatggc aagcggtttg atcgacacca
      541 atttcagcag cacattggca aatgggatgt cggggtgtga tcaaagcact gtcgaatcat
      601 tggccgacga tccaacagat tcaccattcg atgccgatga ttgtctcaag gtgcgcaagt
      661 actggtgctt tctgctgtcc agcatcttta cattccttgc tggcctgctc gtggtgctgc
      721 tatggcgagc cttcgcattc gtttgctgcc gcaaggagcc ggacctgggg cccaacgacc
      781 ccaagcagaa ggaacagaag gcatcccgca acaaacagga gttcgagggc acctttatga
      841 cagaagcgaa agactgggct ggagagctta tctcgggtca aacaacaact ggtcgaattt
      901 tggtcgttct cgtatttata ctcagcattg catccctcat tatatacttc gttgatgcat
      961 ctagcgaaga agtcgaaaga tgccaaaagt ggagtaacaa cattactcaa cagatcgatc
     1021 tcgcattcaa tatatttttt atggtttact tttttatacg attcatagcg gcgtccgata
     1081 agctttggtt tatgttagaa atgtacagtt ttgtagatta ttttacaata cccccgtcct
     1141 tcgtatcaat atatttagat cgaacatgga tcggtcttcg atttcttcga gcgctacgtc
     1201 tcatgactgt tccagatatt ttacaatatt taaacgtact aaaaacatcg agctccatac
     1261 gcttggctca actagtatca atttttatat ccgtgtggtt aacagcagcg ggcattatac
     1321 atctgctgga gaactctggc gatccgctgg attttgataa tgctcatcgt ttatcgtatt
     1381 ggacctgtgt ctatttccta attgtgacca tgtcaacggt aggatatggt gacgtttact
     1441 gtgagactgt cctgggaaga acatttctcg tgttctttct gctcgtcggc ttggcaatgt
     1501 ttgccagcag tataccggag ataattgaac tcgtcggtag tggcaataag tatggcggtg
     1561 aactgaaaag agaacacgga aagagacata ttgtggtatg cggtcatata acatacgaat
     1621 ccgtgtcgca tttcctgaag gacttcctcc acgaagatcg ggaggatgtc gatgtcgaag
     1681 tggtctttct ccatcgtaaa ccacccgatt tggaacttga gggtttgttc aaacgtcatt
     1741 ttaccaccgt ggagttcttc caaggaacca ttatgaatcc gatcgatctt cagagggtta
     1801 aggttcatga agccgacgcc tgcctcgtgc tagctaacaa atattgccaa gatcccgacg
     1861 cagaggatgc tgccaacatc atgagagtca tctcgatcaa gaactacagc gacgacattc
     1921 gagtcatcat ccagctgatg cagtaccaca ataaggcata cttgctgaac ataccatcat
     1981 gggattggaa acagggcgac gatgtcatct gcctggccga actgaagctg ggcttcattg
     2041 cccagagttg tttggcgccc gggttctcga ccatgatggc caatctgttc gccatgagat
     2101 cgttcaagac gtcgccagac atgcagtctt ggacaaatga ttacctgcgc ggcactggca
     2161 tggaaatgta cactgaaaca ttgagtccca catttattgg aataccattt gctcaggcca
     2221 ctgaactgtg tttctccaag ctgaagcttc tgctgctggc catcgagatc aagggcgcag
     2281 aagagggggc ggacagcaag atttccatca accctcgggg ggcaaaaatc caggccaaca
     2341 cccagggttt cttcatagca caaagtgccg acgaggtgaa gcgtgcctgg ttctactgca
     2401 aagcgtgtca tgaggacatt aaggacgaga cgctgatcaa gaaatgcaaa tgcaaaaact
     2461 tgactgttca gcccaggagc aaattcgatg acttaggtga tatcactcgt gacagagaag
     2521 atacgaatct actcaatcgc aatgtgcgcc ggccgaatgg cactggcaac ggtacgggtg
     2581 gcatgcacca catgaacaac acggcagcgg cggctgcggc agctgcggcg gcgggaaaac
     2641 aggtgaacaa ggtgaagcca acggtgaatg tgagccggca ggtggagggc caagtgatat
     2701 cgccatcgca gtacaacagg ccgacgagtc gcagttccgg cacgggcaca cagaatcaaa
     2761 atggcggcgt atccttgccc gccggcattg cggacgatca gtcgaaggac tttgatttcg
     2821 agaagaccga aatgaagtac gactcgacgg gcatgttcca ctggagtccg gcaaagagct
     2881 tagaagactg catactggat cgcaaccagg cggccatgac cgtgctgaac ggtcacgtgg
     2941 tcgtgtgcct gtttgccgat cccgattcgc cgctgatcgg gctgcggaat ctggtgatgc
     3001 cgctgcgggc atccaacttc cactaccacg agctgaagca cgtggtcatc gtgggctcgg
     3061 tggactacat acgtcgcgag tggaagatgc tgcagaacct gcccaagatc tcggtgctca
     3121 acggatcgcc gctgagccgt gccgacctgc gggccgttaa cgtcaatctg tgtgatatgt
     3181 gctgcatcct gtcggcgaaa gttcctagca acgacgatcc cacgctggcc gacaaggagg
     3241 cgattctcgc ctcgctgaac atcaaggcga tgacctttga cgacacgatc ggtgtgctca
     3301 gccagcgcgg cccggagttc gacaatctga gcgccaccgc cggcagtccc attgtgctgc
     3361 agcggagggg ctcggtctat ggcgccaatg tgcccatgat aacagaactg gtcaatgatg
     3421 gtaacgtgca gtttctcgat caagacgacg acgatgatcc agatacagaa ctctatctga
     3481 cgcagccttt cgcctgcggc acagccttcg ctgtgagtgt gttagactcg ctgatgtcca
     3541 cgacttactt caatcaaaac gccttaacgc tgatccgctc actgataacg ggcggcgcca
     3601 cgcccgagct ggaactgatc ctggccgagg gagctggcct ccgtggaggc tacagcactg
     3661 ttgagagtct gagcaatcga gacagatgtc gagtgggtca aatctcactg tacgacggtc
     3721 cgttggctca atttggggag tgcggcaagt atggggacct gtttgtggca gccctcaagt
     3781 cgtacggaat gctgtgcatc ggattatacc gattcaggga caccagctcc agttgtgatg
     3841 cgagcagcaa acgttatgta ataaccaacc cacccgatga cttttcacta ctgccaacag
     3901 atcaggtatt cgttttaatg caattcgatc cgggcctgga gtacaagccg ccagcggtac
     3961 gagcacctgc aggcggacgt ggcaccaaca cacagggttc cggggtcggt gggggcggct
     4021 ccaacaagga tgataactct tgattgttac tgtgtagcgc cttaactgat ggtccttatt
     4081 cgtacatttg aacgatggag aagctaaacg aaggcagagc agcgcatttg tggcaacgca
     4141 tccacaacta catattggca taagatattt gatactcgcg acaaggcgac aacaaatcgg
     4201 cagcgaaaaa aagacatatt tgtatgtaaa tcgattgtac cgtgtacaaa agtgaaatca
     4261 aaagcgttaa taagttagag attacgacca taacttgcgt gccattaatg cgctgctctg
     4321 ctcttttatg tgtgtggggg gatgcggctc ggtgtatttt ggtccatccc aactaacaat
     4381 caagaagaca accggaaccg aaccactgac cacca
//