From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human pulmonary surfactant-associated protein SP-B (SFTP3) mRNA,
Date: 29 Jul 92 10:03:09 GMT
Distribution: bionet
Checksum: 10344    17

LOCUS       HUMSPBAA    10476 bp ds-DNA             PRI       29-JUL-1992
DEFINITION  Human pulmonary surfactant-associated protein SP-B (SFTP3) mRNA,
            complete cds.
ACCESSION   M24461
KEYWORDS    pulmonary surfactant-associated protein SP-B.
SOURCE      Human DNA and lung cDNA to mRNA, clones 4-3 and 7-1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 10476)
  AUTHORS   Pilot-Matias,T.J., Kister,S.E., Fox,J.L., Kropp,K., Glasser,S.W.
            and Whitsett,J.A.
  TITLE     Structure and organization of the gene encoding human pulmonary
            surfactant proteolipid SP-B
  JOURNAL   DNA 8, 75-86 (1989)
  STANDARD  full staff_entry
COMMENT     Draft entry and computer readable copy of sequence [1] kindly
            submitted by T.J.Pilot-Matias 28-APR-1989.
FEATURES             Location/Qualifiers
     CDS             join(1054..1120,1431..1558,2060..2131,2495..2620,
                     3447..3635,3863..3952,5386..5569,5742..5887,7122..7202,
                     7697..7759)
                     /product="pulmonary surfactant-associated protein SP-B"
                     /gene="SFTP3"
                     /codon_start=1
                     /translation="MAESHLLQWLLLLLPTLCGPGTAAWTTSSLACAQGPEFWCQSLE
                     QALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNV
                     LPLKLLMPQCNQVLDDYFPLVIDYFQNQIDSNGICMHLGLCKSRQPEPEQEPGMSDPL
                     PKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRI
                     QAMIPKGALRVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLR
                     CSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREK
                     CKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL"
     exon            1040..1120
                     /number=1
                     /gene="SFTP3"
     intron          1121..1430
                     /number=1
                     /gene="SFTP3"
     exon            1431..1558
                     /note="pulmonary surfactant protein SP-B"
     intron          1559..2059
                     /note="Intron B"
     exon            2060..2131
                     /note="pulmonary surfactant protein SP-B"
     intron          2132..2494
                     /note="Intron C"
     exon            2495..2620
                     /note="pulmonary surfactant protein SP-B"
     intron          2621..3446
                     /note="Intron D"
     exon            3447..3635
                     /note="pulmonary surfactant protein SP-B"
     intron          3636..3862
                     /note="Intron E"
     exon            3863..3952
                     /note="pulmonary surfactant protein SP-B"
     intron          3953..5385
                     /note="Intron F"
     exon            5386..5569
                     /number=7
                     /note="pulmonary surfactant protein SP-B"
     intron          5570..5741
                     /note="Intron G"
     exon            5742..5887
                     /number=8
                     /note="pulmonary surfactant protein SP-B"
     variation       5838
                     /note="c in DNA; t in cDNA"
     intron          5888..7121
                     /note="Intron H"
     exon            7122..7202
                     /number=9
                     /note="pulmonary surfactant protein SP-B"
     intron          7203..7696
                     /note="Intron I"
     exon            7697..7779
                     /number=10
                     /gene="SFTP3"
     intron          7779..9552
                     /number=J
                     /gene="SFTP3"
     exon            9553..10375
                     /number=11
                     /gene="SFTP3"
     variation       9691
                     /note="g in DNA; c in cDNA"
     variation       10345
                     /note="g in DNA; a in cDNA"
BASE COUNT     2416 a   3059 c   2944 g   2057 t
ORIGIN
        1 ggatcctccc tcctcggcct cccaaagtgc caggattaca ggagtgagcc accacaccca
       61 gccccatctc ttttcatcat ggtactaatt cctgcccgtc cacccacaaa agcactgtag
      121 tcgttcccga gtatagaggc ctgtgagcct ccactaggga gagggctcct gcagagatca
      181 gataaattga tcacaatggc tggggtggtg gcaatgtgct aatgctctct ttcttccact
      241 caagatatcc tctgtctccc tcagcctgtg agctttttct ccagtgtgct ctgccagtgg
      301 gggccctgcc tgagagcccc tgcagctgca gaggacagtt tctttctgct gaaccatcgc
      361 agctatgccc cagcccctac cctggagggg tccccagggg ccatgggcag cacctcctgt
      421 atagggctgt ctgggagcca ctccagggcc acagaaatct tgtctctgac tcagggtatt
      481 ttgttttctg ttttgtgtaa atgctcttct gactaatgca aaccatgtgt ccatagaacc
      541 agaagatttt tccaggggaa aaggtaagga ggtggtgaga gtgtcctggg tctgcccttc
      601 cagggcttgc cctgggttaa gagccaggca ggaagctctc aagagcattg ctcaagagta
      661 gagggggcct gggaggccca gggaggggat gggaggggaa cacccaggct gcccccaacc
      721 agatgccctc caccctcctc aacctccctc ccacggcctg gagaggtggg accaggtatg
      781 gaggcttgag agcccctggt tggaggaagc cacaagtcca ggaacatggg agtctgggca
      841 gggggcaaag gaggcaggaa caggccatca gccaggacag gtggtaaggc aggcaggagt
      901 gttcctgctg ggaaaaggtg ggatcaagca cctggagggc tcttcagagc aaagacaaac
      961 actgaggtcg ctgccactcc tacagagccc ccacgccccg cccagctata aggggccatg
     1021 ccccaagcag ggtacccagg ctgcagaggt gccatggctg agtcacacct gctgcagtgg
     1081 ctgctgctgc tgctgcccac gctctgtggc ccaggcactg gtgagtctcc cccagcctcc
     1141 cctctcctag gcagctccac cactcactga gcactgcttt gtgctaggca ttaacccaag
     1201 tctgtcctca ttttaaagac aaggcagctg gggttcagag agggttcaga gcttatccaa
     1261 ggtcacacag ctggcgggtc caggagcagg tggaacccag agctgtctga cgtccacatg
     1321 tttaatggcc tcacactccc agcaaaactg ggtctagagg gtgggtgaaa tcatgatgcc
     1381 aggtgtgtag cctggatcct gattaaggtt gctctggccc caaaccacag ctgcctggac
     1441 cacctcatcc ttggcctgtg cccagggccc tgagttctgg tgccaaagcc tggagcaagc
     1501 attgcagtgc agagccctag ggcattgcct acaggaagtc tggggacatg tgggagccgt
     1561 gagtaccacc aaggatgcat ggcaactggg ggtctgaaat gaagggtgct gggtgggctc
     1621 tggatgggca ggaggagagt ggagccccca taggggatgg atgagatgaa atgggatgag
     1681 atgaaatgag ataggataaa atggaatggg atggatgcga tgggatacga tgacatagaa
     1741 tagatggagt cggatgaatg ggatgggatg ggatggatgg gaggggaagg gataggatag
     1801 gatgacatag aataaagatg gatgggatgg gatgggatgg gatgggatga cacagaataa
     1861 agatggatgg attgggatgg atgaatagaa gagatggatg ggataaattg atatggatga
     1921 gatgggacaa gttgggctgg tgggcagctg catgtgcctt ggagtgctct gttggcctct
     1981 tcctaagaga acctccccat tggagctggg agcctccccc actcatgtgt cctccacctt
     2041 ggggcccctc cctccccagg atgacctatg ccaagagtgt gaggacatcg tccacatcct
     2101 taacaagatg gccaaggagg ccattttcca ggtaatgatg cccagatcct ggatgaaggt
     2161 tggggcccaa gagatgaggg acagagcagg gaagagctga gccccctaaa ggggccattt
     2221 ccaggctgag gaggaggcct gggtgcctgg gaagtcccag ctcctcctgg ctgggagcag
     2281 gtcatggccc tgagctcaat agcacagcca gagatggtct tccctgaggg gaagggcccc
     2341 tacatgtgcc caactactta actccttggc actcgtgaac tccagcaccc tgggggatta
     2401 ggggtcagtc tgccctggtg gggccttgtg tccagggact tgggcggggt agacctcaga
     2461 gaggcccagc tgacggcccc ctctggcctc ccaggacacg atgaggaagt tcctggagca
     2521 ggagtgcaac gtcctcccct tgaagctgct catgccccag tgcaaccaag tgcttgacga
     2581 ctacttcccc ctggtcatcg actacttcca gaaccagatt gtgagggctg caagctcacc
     2641 tcctgcctgc ctccccacgc aggcccctgt gcccacccat gggggagcca cacacacagc
     2701 accccagcca gccagacaca cacacacaca cacacacaca cagcacccaa gccggccaga
     2761 cacaaacaca cagcacccca gccagccgga cacacacaca cacacacaca cacaacaccc
     2821 cagctggccg gacacacaca cacacagtac cccagctggc cggacacaca cacacacagc
     2881 accctatcca gacacataca cacacacagt accccagcca gctggaaaca cacacacaca
     2941 cagcactcca tccagacaca tacccacaca gtaccccagc cagccagaca cacacacaca
     3001 cacacacaca cacacacaca cagagcacac acacagcacc ccagctggcc acacacacac
     3061 acacacacac cctgtccaca aagggcctag gaaactacgt gcccttcagc catgcacccg
     3121 accatgggcc cccaggttca ggtgcacacg gtgggcctgt acgctcacac acccttacac
     3181 cctcactctc acacacatgc ttacacactt attcattctc acatatatgc tcatgctcat
     3241 tcacacacaa tcccgggcca cctgccctaa agtccccaca cagccctatc tttgcctttt
     3301 gtccccccac atagagttct aaaccacagc acccccacta ggcctgcttc ctcccattcc
     3361 agtggtccct gagcccttgg gccggcctga ataggggtgg gcttccctcc cagaccctaa
     3421 cactcccacc ctgtgctgtg ccccaggact caaacggcat ctgtatgcac ctgggcctgt
     3481 gcaaatcccg gcagccagag ccagagcagg agccagggat gtcagacccc ctgcccaaac
     3541 ctctgcggga ccctctgcca gaccctctgc tggacaagct cgtcctccct gtgctgcccg
     3601 gggccctcca ggcgaggcct gggcctcaca cacaggtgag ggaggccccc acagccagta
     3661 aagtggagat ccagagggct agagccacct ccgaagccca tgggcactgg gccctgggag
     3721 aggcagagcc gggaaggtga taggaagctc caggcagggc ctaagggagg agggagagaa
     3781 agggaggaag agagagggga ggagagcctg gaggactctt ctcccagcac ccagcctggc
     3841 ctccacctga ttctttcccc aggatctctc cgagcagcaa ttccccattc ctctccccta
     3901 ttgctggctc tgcagggctc tgatcaagcg gatccaagcc atgattccca aggtgaggca
     3961 tccagggcct caagagccca ggagcacacg catacctgta gctccctgca gctcccacct
     4021 ctctcccaac tcacaccccc gtcagaccca gctggctgcc agaagttagg aggggagaga
     4081 gccgcttgtg cattgccccc acccagggac cctgggctca ggctcaggcc tggtaggtgc
     4141 caggtacagt tcatgcaaca aacattaagc ccccactgta tggaggtgcc agccaggagc
     4201 caaagtacaa aaacggacaa gacgcagctt tgtcctccag cagctcacca tctgatggag
     4261 aaagatcccc agaggtctct gtagaaaggt tgctttgatc tttcaagagg ggaatttcca
     4321 cagatagatt ccccatcctt gcctgagtcc aacttggagt cttccagacc tgcagtggct
     4381 attgtccaat ggccccgcca gcccagggct accttgccca aattggggcc caaatgagga
     4441 aaggccctgc cccctcagcc tttcccagat tgggttgcgt gggccaccag gggcacaagg
     4501 cagcaggtga ggttcctgct gaggcaggtg gttcacttga gcccaggagt tcaagaccag
     4561 cttgggcaac atggcgaaac cccgtctcta ctaagaatac aaaaattagc cagatgtgac
     4621 aggtgcctgt agtcccagct actcgggagg ctgaggcagg agaatcactt gaacccagga
     4681 ggcggaggtt gcagtgagcc gacatcacgc cactgtactc tagcctgggt gacagagcaa
     4741 gactctgtct caaaaaaaaa gaaagaagga aagatcactg cagagattgc agtgagaggt
     4801 gatgggacag ggacggagct gagggctggc ctggggatgc atttgggagg tgggcccact
     4861 gctatgggca tggatgggcc tggagcgtga ggaccaggga ggactccaaa gtgactttta
     4921 cacactggcc agagcaacca gccctctgta atgccagcag ctgagatggg gagactaaag
     4981 aagaaaacag gtttgagcaa aaaaacagag agctccctcc tggccatgtt gagttcaaga
     5041 tgcctgtgtg aagtgcagga gaggagagtc aggcaagcag ctgaatccca agcattgggg
     5101 gaaggtcagg tccaccatgt cagtctgaga gtcactagct gtgggccaga gcctttgggg
     5161 ccagacgtag gtctgaagct ggctcctaca ctcagtgacc ctgtgtgagt cccctgcatc
     5221 ccctggactc tctgatcccc agtgtcctta tttgtgaata gccttgccct cccttctaga
     5281 agagaatgag ggaatgcgta ggaagtgccc agctgggtgc tgggcagaga gtggaggctt
     5341 gccaagtgaa ggtcccatgc tggcctctct ccgcccccgc cccagggtgc gctacgtgtg
     5401 gcagtggccc aggtgtgccg cgtggtacct ctggtggcgg gcggcatctg ccagtgcctg
     5461 gctgagcgct actccgtcat cctgctcgac acgctgctgg gccgcatgct gccccagctg
     5521 gtctgccgcc tcgtcctccg gtgctccatg gatgacagcg ctggcccaag tgagcccact
     5581 gccccctcct tagcccaatg cccgctctcc tcctccccct accctgccac tgcatgaccc
     5641 tctccctctg tggtcccact gcaatgcacc aaggaggaca gaaaccaaac acctctgtag
     5701 ggtggccttg cctgctttcc ccctaatgct cacatctcca gggtcgccga caggagaatg
     5761 gctgccgcga gactctgagt gccacctctg catgtccgtg accacccagg ccgggaacag
     5821 cagcgagcag gccataccac aggcaatgct ccaggcctgt gttggctcct ggctggacag
     5881 ggaaaaggta tgggctgggc acatggggac tcatggtcag ggcccgttca aggcagaagg
     5941 ctgagcccag gaaaggcttt gcagccagag acacctagga tgggccagaa tggagcacag
     6001 acaggcagac aggatgtggg gcagacaatg gtgggactgt aagttagggc agagcctgct
     6061 aagggttagg agtcgcctct ggacaaaggg ctgtgggctc cagaggacca gcaggccctc
     6121 ttcacgggct gagtgagcac caggcaagcc ttcagaggcc tggttatcta ccaggagatg
     6181 agtaatgcta gggccagttc aagccaggaa agggactagc cttctctcca gggtcctgat
     6241 ccctttactg cccccacact cctcaaggtg tgactcactc aggacaaacc cattggcaaa
     6301 aggagagggc tggacttgaa ggtcctaggg cccttgccaa tactcagtca atgacaggaa
     6361 attccctttt tttttttttt tttttttttt ttgagatgga gttttgctct tgttgcccag
     6421 gctggagtgc aatggcacaa tcttggctca ctgcaacctc tgcctccggg ttcaggcgat
     6481 tctcctgcct cagcctcttg agtagctggg attacaggca tgtgctacca ggcccggcta
     6541 atttttgtat ttttagtaga gacaaggttt caccatattg gtcaggctgg tctcgaaccc
     6601 ctgacctgaa gtgatctgcc cgccttggcc tcccaaagtg ctgggattac aggcataagc
     6661 cactgcaccc ggacaggaaa ttcccttctt aaagcgagat cctgtcctga ggaaagccag
     6721 ctgatgctct tcccaggagg cagctgtcca cactgtgctc cctgctcagc aactcccaag
     6781 cctcccgact gcccatcaca tctggtctca aggaccagat gaacgttaag gttccttcta
     6841 gaactgaaat ggaggtggag ggaggggagg gtggtggctg agattccacc cctctgcctg
     6901 agtcctccgt ctccagtgtc gcctgctttt ctgatggaag tcctccattt cagcctggct
     6961 ccagtttgtt aagggtttca actgcagcca gaggtgttcc gtgagggctg atggaggagt
     7021 cgggagggag ccctagagtg atccagagat gtggagaggc ccaggaccac acgacaggag
     7081 agtcctgcaa agggacctcc acagctgtgt gtctccctca gtgcaagcaa tttgtggagc
     7141 agcacacgcc ccagctgctg accctggtgc ccaggggctg ggatgcccac accacctgcc
     7201 aggtacaccc aacccctccc aagttggtcc taggacttcc cttggctccc agagccccca
     7261 ccctttgggc ccgtgatcct cagaggcctc actcccctgg gtccaaggtg gtcccaggtg
     7321 cacgggccag ggactgggag gcacccctct ctgtttcagt gtaaaaaatc atgagagcat
     7381 ggaaaagggg gatgggaagg gagggatggc ctgaggagtg cggctggatg tccattatag
     7441 gatggggctg tgttccctgg ccagtgtgtg ctggtggggt gggggtacaa agtgggtgtt
     7501 ctggagtgaa catctcacct cctcaggctc taaaccctaa ggcctgtggc tcagggagtg
     7561 gccgaggggt ctacagagtc acactggtag cacccactag gcgggaggtg gagtgagtgc
     7621 tgttctttcc cggaagagct gggtgtgggg agctgagggg gcccaggcct cagccctggt
     7681 gctgtccctg tgacaggccc tcggggtgtg tgggaccatg tccagccctc tccagtgtat
     7741 ccacagcccc gacctttgat gagaactcag ctgtccaggt gagtccaggc ccccagttgc
     7801 ggggaggtaa gggggcaggt cctgaccatc agggcatggg aggcccttct gctccccaag
     7861 caggaagagg cggccactcc tgccggctgc tccatcctcc ctctcaccgc acagctggag
     7921 gctcctgagg gcttctggct ggccatcagg aaaacaccct ttccggaccc cgagcactgc
     7981 cccgcccaga accccagtca ctgagtgccc aacccccagc ttccccccca accccccgcc
     8041 ctgccctgtc ccaggcctcc ctctcagagc ttgccccagg gactctctgg ccctcagggt
     8101 tcaatgtatt ctgaccaagg ccaagctttc ctggggctca gggaaaatca cactttgcta
     8161 cccgaagctg tatcccctca gatgccagga aggccgtgat catctgactc caccctcctg
     8221 agacacattc tctccctgac tgtcctgttc taagtcagcg gagcacctta ggatggaggg
     8281 gtggaggcga ggccagatgc agcctctgtg aacaggtgcc tggaggctgg gaaatgaccc
     8341 tgagagggca ggacacagca accgtgggct taaggtgacc ttgagagcaa gcttggccca
     8401 ctttacaatt ctgttcagag ccagccccta acatggtggt catttattca tttgttccct
     8461 cattttaaaa aatgtaaggc caggcatggt ggctcacgcc ggtaatccca gcactttggg
     8521 aggccgaggc aggcagatca cctgaggtca ggagttcgag actagcctgg ccaacatggc
     8581 gaaaccctgt ctctactaaa aatatttttt aaaaattagc tgagcatggt ggcaggtgcc
     8641 tgtaatccca gctactcagg acgcttaggc aggagaatca cttgaacctg ggaggcgaag
     8701 gttgcggtgt gctgagatcg tgccactgca ctctagccta ggcaacagag cacaactctg
     8761 tctcaggaaa aaaaaaaaaa aaaaaaaagg tatttctttg ctgggcgcag tggctcacac
     8821 ctgtaatccc agcactttgg gagaccgagg cgagtggatc acttgaggtc aggagttcaa
     8881 gaccagcctt accaacatga tgaaaccccg tatctactaa aaaaaaaaaa aaaaaaaaaa
     8941 aaaaaattag ccagatgtgg tggcacacac ctgtaatccc agctacttgg gaggctgagg
     9001 aggagaattg cttgaacctg ggaggcggag attgcagcga gccaagattg cgcctctgca
     9061 ctccagcctg ggtgacagag tgagactccg tctcaaaaaa aaaaaaaaaa aagtagtggg
     9121 tgcctgtggc caggccacat cctagggtag gggctatggc tgagccctgc cctcctggag
     9181 ctcacagcca agtccacttc ttccatctga ggcggggaag ccagccctgt tcctgaaacc
     9241 ctgcatcaca agcccctgtg ggaggcagtg gggaggggag gtcctccccc actcagacct
     9301 gacccacagg gaccagttta atgtgtcctt gccccagtga tgacagctgg ggatctgggg
     9361 gtggggagtc acccaggacc cgggcagtcg cctttcccca gctcctaggg ctcccggcct
     9421 tccctgctga aacagcaaga ccagtgggtt ggcgtgggag gcctgggctt caaaccacct
     9481 ctgctatcac ctggctgtgg gtccccaggc aggacataca cacagtccct ctctggccct
     9541 catcctcctc agctgcaaag gaaaagccaa gtgagacggg ctctgggacc atggtgacca
     9601 ggctcttccc ctgctccctg gccctcgcca gctgccaggc tgaaaagaag cctcagctcc
     9661 cacaccgccc tcctcaccgc ccttcctcgg gagtcacttc cactggtgga ccacgggccc
     9721 ccagccctgt gtcggccttg tctgtctcag ctcaaccaca gtctgacacc agagcccact
     9781 tccatcctct ctggtgtgag gcacagcgag ggcagcatct ggaggagctc tgcagcctcc
     9841 acacctacca cgacctccca gggctgggct caggaaaaac cagccactgc tttacaggac
     9901 agggggttga agctgagccc cgcctcacac ccacccccat gcactcaaag attggatttt
     9961 acagctactt gcaattcaaa attcagaaga ataaaaaatg ggaacataca gaactctaaa
    10021 agatagacat cagaaattgt taagttaagc tttttcaaaa aatcagcaat tccccagcgt
    10081 agtcaagggt ggacactgca cgctctggca tgatgggatg gcgaccgggc aagctttctt
    10141 cctcgagatg ctctgctgct tgagagctat tgctttgtta agatataaaa aggggtttct
    10201 ttttgtcttt ctgtaaggtg gacttccagc ttttgattga aagtcctagg gtgattctat
    10261 ttctgctgtg atttatctgc tgaaagctca gctggggttg tgcaagctag ggacccattc
    10321 ctgtgtaata caatgtctgc accagtgcta ataaagtcct attctctttt atgagaaaga
    10381 aaaagacacc agtcctttaa agtgctgcag tatggccaga cgtggtggct cacacctgca
    10441 atcccagcac cttaggaggc cgaggcagga ggatcc
//