From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Avian retrovirus tyrosine kinase (v-ryk) oncogene mRNA, complete
Date: 29 Sep 92 10:02:31 GMT
Distribution: bionet
Checksum: 25729     7

LOCUS       AREVRYK      3010 bp ss-mRNA            VRL       29-SEP-1992
DEFINITION  Avian retrovirus tyrosine kinase (v-ryk) oncogene mRNA, complete
            cds, and glycoprotein 85 (gp85) mRNA, 3' end.
ACCESSION   M92847
KEYWORDS    glycoprotein 37; glycoprotein 85; oncogene; polyprotein;
            tyrosine kinase.
SOURCE      Avian retrovirus cDNA to mRNA.
  ORGANISM  Avian retrovirus
            Viridae; ss-RNA enveloped viruses; Positive strand RNA virus;
            Retroviridae; Oncovirinae; Type C oncovirus group;
            Avian myelocytomatosis viruses.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Jia,R., Mayer,B.J., Hanafusa,T. and Hanafusa,H.
  TITLE     A novel oncogene, v-ry-kappa, encoding a truncated receptor
            tyrosine kinase is transduced into the RPL30 virus without loss of
            viral sequences
  JOURNAL   J. Virol. 66, 5975-5987 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             <1..2100
                     /product="polyprotein"
                     /codon_start=1
                     /translation="FPILPGVWVDSTQGNFTKPKALPPAIFLICGDRAWQGIPSRPVG
                     GPCYLGKLTMLAPNHTDIHKILANSSQTGVRHFRSVSHLDDTCSDEVQLWGPTARIFA
                     SILAPGVAAAQALREIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFL
                     LLAHGHGCKDIAGMCCFNLSDHSEAIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGI
                     GEWAIHLLKGLLLGLVVILLLVVCLPCLLQFVSSSTRKMTTTVVNYTAKKSYCRRAVE
                     LTLGSLGVSSELQQKLQDVVIDRNALSLGKVLGEGEFGSVMEGRLSQPEGTPQKVAVK
                     TMKLDNFSHREIEEFLSEAACIKDFDHPNVIKLLGVCIELSSQQIPKPMVVLPFMKYG
                     DLHSFLLRSRLEMAPQFVPLQMLLKFMVDIALGMEYLSSRQFLHRDLAARNCMLRDDM
                     TVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTTKSDVWAFGVTMWEI
                     ATRGMTPYPGVQNHEIYEYLFHGQRLKKPENCLDELYDIMSSCWRAEPADRPTFSQLK
                     VHLEKLLESLPAPRGSKDVIYVNTSLPEESPDSTQDLGLDSVIPQADSDLDPGDIAEP
                     CCSHTKAALVAVDIHDGGSRYVLESEGSPTEDAYVPQLPHEGSAWTEASTLPVGSSLA
                     AQLPCADGCLEDSEALL"
     mat_peptide     1..234
                     /product="glycoprotein 85"
                     /gene="gp85"
                     /codon_start=1
                     /partial
     misc_feature    235..772
                     /function="'5' gp37 of the RPL30 virus'"
     mat_peptide     235..2097
                     /product="glycoprotein 37"
                     /gene="gp37-ryk"
                     /codon_start=1
     mat_peptide     772..2097
                     /product="v-ryk tyrosine kinase"
                     /gene="v-ryk"
                     /codon_start=1
     misc_feature    773..2162
                     /function="'the v-ryk tyrosine kinase oncogene in the
                     RPL30 virus'"
     misc_feature    2163..3010
                     /function="'3' gp37 and 3' LTR of the RPL30 virus'"
BASE COUNT      753 a    711 c    844 g    702 t
ORIGIN
        1 ttcccgattc tcccgggagt atgggtcgac agcacacaag gaaatttcac taaaccaaaa
       61 gcgctaccac ccgcaatttt cctcatttgc ggggatcgcg catggcaggg aattcctagt
      121 cgtccagtag ggggcccctg ctatctagga aaacttacca tgttagcacc caaccataca
      181 gatattcaca aaatacttgc taattcgtcg caaacagggg tgagacactt tcgaagcgtc
      241 tcacatctgg atgatacatg ctcagacgaa gtgcagcttt ggggtcctac agcaagaatc
      301 tttgcatcta tcttagcccc aggggtagca gccgcgcaag ctctaagaga aatcgagaga
      361 ctagcctgtt ggtctgttaa acaggctaac ttgacaacat cactcctcgg ggacttattg
      421 gatgacgtca caagtattcg acatgcggtc ctgcagaacc gagcggctat tgacttcttg
      481 cttctagctc atggccatgg ctgtaaggac attgccggaa tgtgttgctt caatctgagt
      541 gatcacagcg aagctataca gaagaagttc cagctaatga aagaacatgt caataagatc
      601 ggcgtggaca gcgacccaat cggaagttgg ctgcgaggat tattcggagg aataggtgaa
      661 tgggccatac acttactaaa aggactgctt ttggggcttg tagttatctt attgctagta
      721 gtgtgcctgc cttgcctttt gcagtttgta tctagtagta ctcgaaagat gactactaca
      781 gtggtaaact acacagccaa gaagtcctac tgccggagag ccgtcgaact gacattgggt
      841 agcctgggag tcagcagcga gctccagcag aagctgcagg acgttgtcat tgacagaaat
      901 gccctcagcc tggggaaggt cctgggagag ggggagttcg ggtcagtgat ggagggacgt
      961 ctcagccagc cagaaggcac cccacagaag gtggctgtca agaccatgaa gttggataac
     1021 ttttcccata gagagataga agaattcctc agtgaagcag catgcataaa ggactttgac
     1081 caccccaatg tcatcaagct cctaggtgtg tgcatcgagc tgagctctca gcagatcccc
     1141 aagcccatgg tggttctccc attcatgaaa tatggtgacc tgcacagctt cctgcttcgc
     1201 tcccggctgg agatggcccc ccagttcgtg cccctgcaga tgctgctgaa gttcatggtg
     1261 gatattgccc tgggaatgga gtacctgagc agtcggcagt ttcttcacag ggatttggcg
     1321 gctcggaact gcatgttacg ggatgacatg acggtgtgtg tggcagactt tgggctgtcc
     1381 aagaagatct acagcggcga ttactaccgt cagggccgaa tagcaaaaat gccagtgaag
     1441 tggattgcga tagagtccct ggctgaccgt gtctacacca ccaagagtga tgtgtgggca
     1501 tttggcgtta ccatgtggga gatagcgacc agagggatga ctccgtaccc aggggtgcag
     1561 aaccacgaga tttatgagta tctattccac gggcagcggc tcaaaaagcc tgagaactgc
     1621 ttagatgaac tgtacgatat catgtcctcc tgctggaggg ctgaacctgc tgaccgaccg
     1681 acgttctcac agctgaaagt tcatctggag aagcttttgg aaagccttcc tgccccgagg
     1741 gggtccaagg acgtcatcta cgtcaacacc agcctgccag aggagagccc cgactccacc
     1801 caggatttgg gcttggattc ggtcatcccc caagcggact ctgacttgga ccccggggac
     1861 attgctgagc cctgctgctc ccacacgaag gcagcgctgg tggcagtgga tatccacgat
     1921 gggggctcga ggtacgtcct tgaaagtgag ggcagcccca cagaggatgc ttacgtccca
     1981 cagctgcccc acgagggctc ggcgtggacc gaggccagca ccttgcctgt tggcagctcg
     2041 cttgcagctc agctgccatg tgctgatggc tgcctggagg actccgaagc gctgctgtga
     2101 atggagcctg cgcaaagcag ggtgtgaatc aggacagaga gattttattt taataaacag
     2161 tcttattagt tcactcggct atcgcgagga atacaggaaa ttacaagagg ctagtaggca
     2221 gcctgaaaga gcagtatagg cgggttcctg tattcgtgtg atagctggtt ggaccgttaa
     2281 tcgatcggtt agcatacgga atgtaagagg tcgctgagta gtgcgcgagc aaaatttaag
     2341 ctacaatagg gcaaggcttg accggcagtt gcatgaagaa atctgcttag ggttaggcgt
     2401 tttgcgttgc ttcgcgatgt acgggctagg tttacgcgta actggggggg gccatgatat
     2461 gtataggcgc caacggggct tcggttgtac gcggataggg gccccctcag aaaatagtgg
     2521 aagcgctttt gcatagggag ggggaaatgt agtagtctta atcataggtt aacatgtata
     2581 ttaccaaata agggaatcgc ctgatgcacc aaataaggta ttatatgatc ccattggtgg
     2641 tgaaggagcg acctgagggc atatgggcgt taatagaact gtctgtcctt gcgtcattcc
     2701 ttcctcatcg gatcatgtac gcggcagaat atgattggat aacaggatgg caccattcat
     2761 cgtggcgcat gctgattggt gtgactaagg agttatgtaa cccatgaatg tacttaagct
     2821 tgtagttgct aacaataaag tgccatttta cctcccacca cattggtgtg cacctgggtt
     2881 gatggccgga ccgtcgattc ctgacggcta cgagcacctg agtgaagcag aaggcttcac
     2941 ccaggccatt ctatgactcc atgatcaaaa ctgaaaacgt acactatttt tcccaagcgg
     3001 gacggaattc
//