From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Hepatitis E virus (mexican strain) structural proteins and a
Date: 26 Jan 93 05:47:27 GMT
Distribution: bionet
Checksum: 04323 14

LOCUS       HPENSSP      7180 bp ss-RNA             VRL       25-JAN-1993
DEFINITION  Hepatitis E virus (mexican strain) structural proteins and a
            nonstructural polyprotein genes, complete cds.
ACCESSION   M74506
KEYWORDS    nonstructural protein; structural protein.
SOURCE      Hepatitis E virus cDNA to genomic RNA.
  ORGANISM  Hepatitis E virus
            Viridae; ss-RNA nonenveloped viruses.
REFERENCE   1  (bases 1 to 7180)
  AUTHORS   Huang,C.-C., Nguyen,D., Fernandez,J., Yun,K.Y., Fry,K.E.,
            Bradley,D.W., Tam,A.W. and Reyes,G.R.
  TITLE     Molecular cloning and sequencing of the Mexico isolate of Hepatitis
            E virus (HEV)
  JOURNAL   Virology 191, 550-558 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             4..5079
                     /citation=[1]
                     /note="putative"
                     /product="nonstructural polyprotein"
                     /codon_start=1
                     /translation="MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQVE
                     ILINLMQPRQLVFRPEVFWNHPIQRVIHNELEQYCRARSGRCLEIGAHPRSINDNPNV
                     LHRCFLHPVGRDVQRWYTAPTRGPAANCRRSALRGLPPADRTYCFDGFAGCRFAAETG
                     VALYSLHDLQPADVAEAMARHGMTRLYAAFHLPPEVLLPPGTYRTSSYLLIHDGKRAV
                     VTYEGDTSAGYNHDVATLRTWIRTTKVVGEHPLVIERVRGIGCHFVLLITAAPEPSPM
                     PYVPYPRSTEVYVRSIFGPGGSPSLFPTACAVKSTFHAVPTHIWDRLMLFGATLDDQA
                     FCCSRLMTYLRGISYKVTVGALVANEGWNATEDALTAVITAAYLTICHQRYLRTQAIS
                     KGMRRLELEHAQKFISRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRTLV
                     FDESVPCSCRTTIRRIAGKFCCFMKWLGQECSCFLQPAEGLAGDQGHDNEAYEGSDVD
                     TAEPATLDITGSYIVDGRSLQTVYQALDLPADLVARAARLSATVTVTETSGRLDCQTM
                     IGNKTFLTTFVDGARLEVNGPEQLNLSFDSQQCSMAAGPFCLTYAAVDGGLEVHFSTA
                     GLESRVVFPPGNAPTAPPSEVTAFCSALYRHNRQSQRQSVIGSLWLHPEGLLGLFPPF
                     SPGHEWRSANPFCGESTLYTRTWSTITDTPLTVGLISGHLDAAPHSGGPPATATGPAV
                     GSSDSPDPDPLPDVTDGSRPSGARPAGPNPNGVPQRRLLHTYPDGAKIYVGSIFESEC
                     TWLVNASNAGHRPGGGLCHAFFQRYPDSFDATKFVMRDGLAAYTLTPRPIIHAVAPDY
                     RLEHNPKRLEAAYRETCARRGTAAYPLLGAGIYQVPVSLSFDAWERNHRPFDELYLTE
                     LAARWFESNRPGQPTLNITEDTARAANLALELDSGSEVGRACAGCKVEPGVVRYQFTA
                     GVPGSGKSKSVQQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTSGRRVVIDEAP
                     SLPPHLLLLHMQRAASVHLLGDPNQIPAIDFEHTGLIPAIRPELVPTSWWHVTHRCPA
                     DVCELVRGAYPKIQTTSKVLRSLFWGEPAVGQKLVFTQAAKAAHPGSITVHEAQGATF
                     TTTTIIATADARGLIQSSRAHAIVALTRHTEKCVILDSPGLLREVGISDAIVNNFFLS
                     GGEVGHQRPSVIPRGNPDRNVDVLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCP
                     ELEQGLLYLPQELASCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTRLYDA
                     GHTDVRASLARFIPTLGRVTATTCELFELVEAMVEKGQDGSAVLELDLCSRDVSRITF
                     FQKDCNKFTTGETIAHGKVGQGIFRWSKTFCALFGPWFRAIEKAILSLLPQAVFYGDA
                     YDDSVFSAAVAGASHAMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLVRLYHAV
                     RSAWILQAPKESLRGFWKKHSGEPGSLLWNTVWNMAIIAHCYEFRDLQVAAFKGDDSV
                     VLCSEYRQSPGAGSLIAGCGLKLKADFRPIGLYAGVVVAPGLGALPDVVRFAGRLSEK
                     NWGPDPERAEQLRLAVQDFLRRLTNVAQICVEVVSRVYGVSPGLVHNLIGMLQTIGDG
                     KAHFTESVKPILDLTHSIMHRSE"
     CDS             5076..5447
                     /citation=[1]
                     /note="putative"
                     /product="structural viral protein"
                     /codon_start=1
                     /translation="MNNMWFAAPMGSPPCALGLFCCCSSCFCLCCPRHRPVSRLAAVV
                     GGAAAVPAVVSGVTGLILSPSQSPIFIQPTPLPQTLPLRPGLDLAFANQPGHLAPLGE
                     IRPSAPPLPPVADLPQPGLRR"
     CDS             5117..7096
                     /citation=[1]
                     /note="putative"
                     /product="structural polyprotein"
                     /codon_start=1
                     /translation="MRPRPLLLLFLLFLPMLPAPPTGQPSGRRRGRRSGGTGGGFWGD
                     RVDSQPFAIPYIHPTNPFAPDVAAASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRP
                     ATAGAAALTAVAPAHDTSPVPDVDSRGAILRRQYNLSTSPLTSSVASGTNLVLYAAPL
                     NPPLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTT
                     PTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLV
                     MLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTTCNTNTRVSRYSSTARHSARGA
                     DGTAELTTTAATRFMKDLHFTGLNGVGEVGRGIALTLLNLADTLLGGLPTELISSAGG
                     QLFYSRPVVSANGEPTVKLYTSVENAQQDKGVAIPHDIDLGDSRVVIQDYDNQHEQDR
                     PTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYISDSVTLVNVATGAQA
                     VARSLDWSKVTLDGRPLPTVEQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASD
                     QILIENAAGHRVAISTYTTRLGAGPVAISAAAVLAPRSALALLEDTFDYPGRAHTFDD
                     FCPECRALGLQGCAFQSTVAELQRLKVKVGKTREL"
BASE COUNT     1294 a   2147 c   1907 g   1832 t
ORIGIN      
        1 gccatggagg cccaccagtt cattaaggct cctggcatca ctactgctat tgagcaagca
       61 gctctagcag cggccaactc cgcccttgcg aatgctgtgg tggtccggcc tttcctttcc
      121 catcagcagg ttgagatcct tataaatctc atgcaacctc ggcagctggt gtttcgtcct
      181 gaggtttttt ggaatcaccc gattcaacgt gttatacata atgagcttga gcagtattgc
      241 cgtgctcgct cgggtcgctg ccttgagatt ggagcccacc cacgctccat taatgataat
      301 cctaatgtcc tccatcgctg ctttctccac cccgtcggcc gggatgttca gcgctggtac
      361 acagccccga ctaggggacc tgcggcgaac tgtcgccgct cggcacttcg tggtctgcca
      421 ccagccgacc gcacttactg ttttgatggc tttgccggct gccgttttgc cgccgagact
      481 ggtgtggctc tctattctct ccatgacttg cagccggctg atgttgccga ggcgatggct
      541 cgccacggca tgacccgcct ttatgcagct ttccacttgc ctccagaggt gctcctgcct
      601 cctggcacct accggacatc atcctacttg ctgatccacg atggtaagcg cgcggttgtc
      661 acttatgagg gtgacactag cgccggttac aatcatgatg ttgccaccct ccgcacatgg
      721 atcaggacaa ctaaggttgt gggtgaacac cctttggtga tcgagcgggt gcggggtatt
      781 ggctgtcact ttgtgttgtt gatcactgcg gcccctgagc cctccccgat gccctacgtt
      841 ccttacccgc gttcgacgga ggtctatgtc cggtctatct ttgggcccgg cgggtccccg
      901 tcgctgttcc cgaccgcttg tgctgtcaag tccacttttc acgccgtccc cacgcacatc
      961 tgggaccgtc tcatgctctt tggggccacc ctcgacgacc aggccttttg ctgctccagg
     1021 cttatgacgt accttcgtgg cattagctat aaggtaactg tgggtgccct ggtcgctaat
     1081 gaaggctgga atgccaccga ggatgcgctc actgcagtta ttacggcggc ttacctcaca
     1141 atatgtcatc agcgttattt gcggacccag gcgatttcta agggcatgcg ccggcttgag
     1201 cttgaacatg ctcagaaatt tatttcacgc ctctacagct ggctatttga gaagtcaggt
     1261 cgtgattaca tcccaggccg ccagctgcag ttctacgctc agtgccgccg ctggttatct
     1321 gccgggttcc atctcgaccc ccgcacctta gtttttgatg agtcagtgcc ttgtagctgc
     1381 cgaaccacca tccggcggat cgctggaaaa ttttgctgtt ttatgaagtg gctcggtcag
     1441 gagtgttctt gtttcctcca gcccgccgag gggctggcgg gcgaccaagg tcatgacaat
     1501 gaggcctatg aaggctctga tgttgatact gctgagcctg ccaccctaga cattacaggc
     1561 tcatacatcg tggatggtcg gtctctgcaa actgtctatc aagctctcga cctgccagct
     1621 gacctggtag ctcgcgcagc ccgactgtct gctacagtta ctgttactga aacctctggc
     1681 cgtctggatt gccaaacaat gatcggcaat aagacttttc tcactacctt tgttgatggg
     1741 gcacgccttg aggttaacgg gcctgagcag cttaacctct cttttgacag ccagcagtgt
     1801 agtatggcag ccggcccgtt ttgcctcacc tatgctgccg tagatggcgg gctggaagtt
     1861 catttttcca ccgctggcct cgagagccgt gttgttttcc cccctggtaa tgccccgact
     1921 gccccgccga gtgaggtcac cgccttctgc tcagctcttt ataggcacaa ccggcagagc
     1981 cagcgccagt cggttattgg tagtttgtgg ctgcaccctg aaggtttgct cggcctgttc
     2041 ccgccctttt cacccgggca tgagtggcgg tctgctaacc cattttgcgg cgagagcacg
     2101 ctctacaccc gcacttggtc cacaattaca gacacaccct taactgtcgg gctaatttcc
     2161 ggtcatttgg atgctgctcc ccactcgggg gggccacctg ctactgccac aggccctgct
     2221 gtaggctcgt ctgactctcc agaccctgac ccgctacctg atgttacaga tggctcacgc
     2281 ccctctgggg cccgtccggc tggccccaac ccgaatggcg ttccgcagcg ccgcttacta
     2341 cacacctacc ctgacggcgc taagatctat gtcggctcca ttttcgagtc tgagtgcacc
     2401 tggcttgtca acgcatctaa cgccggccac cgccctggtg gcgggctttg tcatgctttt
     2461 tttcagcgtt accctgattc gtttgacgcc accaagtttg tgatgcgtga tggtcttgcc
     2521 gcgtataccc ttacaccccg gccgatcatt catgcggtgg ccccggacta tcgattggaa
     2581 cataacccca agaggctcga ggctgcctac cgcgagactt gcgcccgccg aggcactgct
     2641 gcctatccac tcttaggcgc tggcatttac caggtgcctg ttagtttgag ttttgatgcc
     2701 tgggagcgga accaccgccc gtttgacgag ctttacctaa cagagctggc ggctcggtgg
     2761 tttgaatcca accgccccgg tcagcccacg ttgaacataa ctgaggatac cgcccgtgcg
     2821 gccaacctgg ccctggagct tgactccggg agtgaagtag gccgcgcatg tgccgggtgt
     2881 aaagtcgagc ctggcgttgt gcggtatcag tttacagccg gtgtccccgg ctctggcaag
     2941 tcaaagtccg tgcaacaggc ggatgtggat gttgttgttg tgcccactcg cgagcttcgg
     3001 aacgcttggc ggcgccgggg ctttgcggca ttcactccgc acactgcggc ccgtgtcact
     3061 agcggccgta gggttgtcat tgatgaggcc ccttcgctcc ccccacactt gctgctttta
     3121 catatgcagc gtgctgcatc tgtgcacctc cttggggacc cgaatcagat ccccgccata
     3181 gattttgagc acaccggtct gattccagca atacggccgg agttggtccc gacttcatgg
     3241 tggcatgtca cccaccgttg ccctgcagat gtctgtgagt tagtccgtgg tgcttaccct
     3301 aaaatccaga ctacaagtaa ggtgctccgt tcccttttct ggggagagcc agctgtcggc
     3361 cagaagctag tgttcacaca ggctgctaag gccgcgcacc ccggatctat aacggtccat
     3421 gaggcccagg gtgccacttt taccactaca actataattg caactgcaga tgcccgtggc
     3481 ctcatacagt cctcccgggc tcacgctata gttgctctca ctaggcatac tgaaaaatgt
     3541 gttatacttg actctcccgg cctgttgcgt gaggtgggta tctcagatgc cattgttaat
     3601 aatttcttcc tttcgggtgg cgaggttggt caccagagac catcggtcat tccgcgaggc
     3661 aaccctgacc gcaatgttga cgtgcttgcg gcgtttccac cttcatgcca aataagcgcc
     3721 ttccatcagc ttgctgagga gctgggccac cggccggcgc cggtggcggc tgtgctacct
     3781 ccctgccctg agcttgagca gggccttctc tatctgccac aggagctagc ctcctgtgac
     3841 agtgttgtga catttgagct aactgacatt gtgcactgcc gcatggcggc ccctagccaa
     3901 aggaaagctg ttttgtccac gctggtaggc cggtatggca gacgcacaag gctttatgat
     3961 gcgggtcaca ccgatgtccg cgcctccctt gcgcgcttta ttcccactct cgggcgggtt
     4021 actgccacca cctgtgaact ctttgagctt gtagaggcga tggtggagaa gggccaagac
     4081 ggttcagccg tcctcgagtt ggatttgtgc agccgagatg tctcccgcat aacctttttc
     4141 cagaaggatt gtaacaagtt cacgaccggc gagacaattg cgcatggcaa agtcggtcag
     4201 ggtatcttcc gctggagtaa gacgttttgt gccctgtttg gcccctggtt ccgtgcgatt
     4261 gagaaggcta ttctatccct tttaccacaa gctgtgttct acggggatgc ttatgacgac
     4321 tcagtattct ctgctgccgt ggctggcgcc agccatgcca tggtgtttga aaatgatttt
     4381 tctgagtttg actcgactca gaataacttt tccctaggtc ttgagtgcgc cattatggaa
     4441 gagtgtggta tgccccagtg gcttgtcagg ttgtaccatg ccgtccggtc ggcgtggatc
     4501 ctgcaggccc caaaagagtc tttgagaggg ttctggaaga agcattctgg tgagccgggc
     4561 agcttgctct ggaatacggt gtggaacatg gcaatcattg cccattgcta tgagttccgg
     4621 gacctccagg ttgccgcctt caagggcgac gactcggtcg tcctctgtag tgaataccgc
     4681 cagagcccag gcgccggttc gcttatagca ggctgtggtt tgaagttgaa ggctgacttc
     4741 cggccgattg ggctgtatgc cggggttgtc gtcgccccgg ggctcggggc cctacccgat
     4801 gtcgttcgat tcgccggacg gctttcggag aagaactggg ggcctgatcc ggagcgggca
     4861 gagcagctcc gcctcgccgt gcaggatttc ctccgtaggt taacgaatgt ggcccagatt
     4921 tgtgttgagg tggtgtctag agtttacggg gtttccccgg gtctggttca taacctgata
     4981 ggcatgctcc agactattgg tgatggtaag gcgcatttta cagagtctgt taagcctata
     5041 cttgacctta cacactcaat tatgcaccgg tctgaatgaa taacatgtgg tttgctgcgc
     5101 ccatgggttc gccaccatgc gccctaggcc tcttttgctg ttgttcctct tgtttctgcc
     5161 tatgttgccc gcgccaccga ccggtcagcc gtctggccgc cgtcgtgggc ggcgcagcgg
     5221 cggtaccggc ggtggtttct ggggtgaccg ggttgattct cagcccttcg caatccccta
     5281 tattcatcca accaacccct ttgccccaga cgttgccgct gcgtccgggt ctggacctcg
     5341 ccttcgccaa ccagcccggc cacttggctc cacttggcga gatcaggccc agcgcccctc
     5401 cgctgcctcc cgtcgccgac ctgccacagc cggggctgcg gcgctgacgg ctgtggcgcc
     5461 tgcccatgac acctcacccg tcccggacgt tgattctcgc ggtgcaattc tacgccgcca
     5521 gtataatttg tctacttcac ccctgacatc ctctgtggcc tctggcacta atttagtcct
     5581 gtatgcagcc ccccttaatc cgcctctgcc gctgcaggac ggtactaata ctcacattat
     5641 ggccacagag gcctccaatt atgcacagta ccgggttgcc cgcgctacta tccgttaccg
     5701 gcccctagtg cctaatgcag ttggaggcta tgctatatcc atttctttct ggcctcaaac
     5761 aaccacaacc cctacatctg ttgacatgaa ttccattact tccactgatg tcaggattct
     5821 tgttcaacct ggcatagcat ctgaattggt catcccaagc gagcgccttc actaccgcaa
     5881 tcaaggttgg cgctcggttg agacatctgg tgttgctgag gaggaagcca cctccggtct
     5941 tgtcatgtta tgcatacatg gctctccagt taactcctat accaataccc cttataccgg
     6001 tgcccttggc ttactggact ttgccttaga gcttgagttt cgcaatctca ccacctgtaa
     6061 caccaataca cgtgtgtccc gttactccag cactgctcgt cactccgccc gaggggccga
     6121 cgggactgcg gagctgacca caactgcagc caccaggttc atgaaagatc tccactttac
     6181 cggccttaat ggggtaggtg aagtcggccg cgggatagct ctaacattac ttaaccttgc
     6241 tgacacgctc ctcggcgggc tcccgacaga attaatttcg tcggctggcg ggcaactgtt
     6301 ttattcccgc ccggttgtct cagccaatgg cgagccaacc gtgaagctct atacatcagt
     6361 ggagaatgct cagcaggata agggtgttgc tatcccccac gatatcgatc ttggtgattc
     6421 gcgtgtggtc attcaggatt atgacaacca gcatgagcag gatcggccca ccccgtcgcc
     6481 tgcgccatct cggccttttt ctgttctccg agcaaatgat gtactttggc tgtccctcac
     6541 tgcagccgag tatgaccagt ccacttacgg gtcgtcaact ggcccggttt atatctcgga
     6601 cagcgtgact ttggtgaatg ttgcgactgg cgcgcaggcc gtagcccgat cgcttgactg
     6661 gtccaaagtc accctcgacg ggcggcccct cccgactgtt gagcaatatt ccaagacatt
     6721 ctttgtgctc ccccttcgtg gcaagctctc cttttgggag gccggcacaa caaaagcagg
     6781 ttatccttat aattataata ctactgctag tgaccagatt ctgattgaaa atgctgccgg
     6841 ccatcgggtc gccatttcaa cctataccac caggcttggg gccggtccgg tcgccatttc
     6901 tgcggccgcg gttttggctc cacgctccgc cctggctctg ctggaggata cttttgatta
     6961 tccggggcgg gcgcacacat ttgatgactt ctgccctgaa tgccgcgctt taggcctcca
     7021 gggttgtgct ttccagtcaa ctgtcgctga gctccagcgc cttaaagtta aggtgggtaa
     7081 aactcgggag ttgtagttta tttggctgtg cccacctact tatatctgct gatttccttt
     7141 atttcctttt tctcggtccc gcgctccctg aaaaaaaaaa
//