From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human MHC class I HLA-B35 (subtype B*3508) mRNA, complete cds.
Date: 28 Dec 92 21:43:23 GMT
Distribution: bionet
Checksum: 09476 4

LOCUS       HUMHLANF     1089 bp ss-mRNA            PRI       02-DEC-1992
DEFINITION  Human MHC class I HLA-B35 (subtype B*3508) mRNA, complete cds.
ACCESSION   L04696
KEYWORDS    HLA-B35 antigen; cell surface antigen; class I gene;
            integral membrane protein; lymphocyte antigen;
            major histocompatibility complex.
SOURCE      Homo sapiens (individual_isolate 22338) blood cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Theiler,G., Pando,M., Delfino,J.M., Takiguchi,M. and Satz,M.L.
  TITLE     Isolation and characterization of two new functional subtypes of
            HLA-B35
  JOURNAL   Tissue Antigens (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     exon            1..73
                     /number=1
                     /gene="HLA-B"
                     /partial
     exon            74..343
                     /number=2
                     /gene="HLA-B"
     exon            344..619
                     /number=3
                     /gene="HLA-B"
     exon            620..895
                     /number=4
                     /gene="HLA-B"
     exon            896..1012
                     /number=5
                     /gene="HLA-B"
     exon            1013..1045
                     /number=6
                     /gene="HLA-B"
     exon            1046..>1089
                     /number=7
                     /gene="HLA-B"
     CDS             1..1089
                     /standard_name="HLA-B*3507"
                     /gene="HLA-B"
                     /note="subtype B*3508 differs at residue 156 (Leu->Arg)
                     with subtype B*3501"
                     /codon_start=1
                     /translation="MRVTAPRTVLLLLWGAVALTETWAGSHSMRYFYTAMSRPGRGEP
                     RFIAVGYVDDTQFVRFDSDAASPRTEPRAPWIEQEGPEYWDRNTQIFKTNTQTYRESL
                     RNLRGYYNQSEAGSHIIQRMYGCDLGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAA
                     DTAAQITQRKWEAARVAEQRRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPV
                     SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSG
                     EEQRYTCHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRR
                     KSSGGKGGSYSQAASSDSAQGSDVSLTA"
BASE COUNT      222 a    336 c    359 g    172 t
ORIGIN      
        1 atgcgggtca cggcgccccg aaccgtcctc ctgctgctct ggggggcagt ggccctgacc
       61 gagacctggg ccggctccca ctccatgagg tatttctaca ccgccatgtc ccggcccggc
      121 cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacccagtt cgtgaggttc
      181 gacagcgacg ccgcgagtcc gaggacggag ccccgggcgc catggataga gcaggagggg
      241 ccggagtatt gggaccggaa cacacagatc ttcaagacca acacacagac ttaccgagag
      301 agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca catcatccag
      361 aggatgtatg gctgcgacct ggggcccgac gggcgcctcc tccgcgggca tgaccagtcc
      421 gcctacgacg gcaaggatta catcgccctg aacgaggacc tgagctcctg gaccgcggcg
      481 gacaccgcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgtggc ggagcagcgg
      541 agagcctacc tggagggcct gtgcgtggag tggctccgca gatacctgga gaacgggaag
      601 gagacgctgc agcgcgcgga ccccccaaag acacacgtga cccaccaccc cgtctctgac
      661 catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc
      721 tggcagcggg atggcgagga ccaaactcag gacactgagc ttgtggagac cagaccagca
      781 ggagatagaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga
      841 tacacatgcc atgtacagca tgaggggctg ccgaagcccc tcaccctgag atgggagcca
      901 tcttcccagt ccaccatccc catcgtgggc attgttgctg gcctggctgt cctagcagtt
      961 gtggtcatcg gagctgtggt cgctactgtg atgtgtagga ggaagagctc aggtggaaaa
     1021 ggagggagct actctcaggc tgcgtccagc gacagtgccc agggctctga tgtgtctctc
     1081 acagcttga
//