From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens GSTM16 gene for glutathione S-transferase
Date: 28 Dec 92 21:43:20 GMT
Distribution: bionet
Checksum: 29520 7

LOCUS       HUMGSTM16    2667 bp ds-DNA             PRI       02-DEC-1992
DEFINITION  H.sapiens GSTM16 gene for glutathione S-transferase
ACCESSION   X68676
KEYWORDS    GSTM16 gene; drug metabolism; transferring capacity;
            transforming capacity.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Zhong,S., Spurr,N.K., Hayes,J.D. and Wolf,C.R.
  TITLE     Deduced amino acid sequence, gene structure and chromosomal
            location; novel human class mu glutathione S-transferase (GSTM4)
  JOURNAL   Biochem. J. (1992) In press
  STANDARD  full automatic
COMMENT     *source: stage=adult; *source: cell_type=lymphoblastoid; *source:
            cell_line=human transformed lymphoblastoid, GST6; *source: clone=
            phGSTM16-1; *source: isolate=GST5; *source: chromosome=1p;
               Related sequences: J03817 & X51451
               From EMBL    entry HSGSTM16;  dated 26-OCT-1992.
FEATURES             Location/Qualifiers
     exon            <1..36
                     /number=1
     mRNA            join(<1..36,304..379,798..862,1156..1237,1333..1433,
                     2374..2469,2557..>2667)
                     /gene="GSTM16"
                     /partial
     intron          37..303
                     /number=1
     exon            304..379
                     /number=2
     intron          380..797
                     /number=2
     exon            798..862
                     /number=3
     intron          863..1155
                     /number=3
     exon            1156..1237
                     /number=4
     intron          1238..1332
                     /number=4
     exon            1333..1433
                     /number=5
     intron          1434..2373
                     /number=5
     exon            2374..2469
                     /number=6
     intron          2470..2556
                     /number=6
     exon            2557..>2667
                     /number=7
     CDS             join(1..36,304..379,798..862,1156..1237,1333..1433,
                     2374..2469,2557..>2667)
                     /EC_number="2.5.1.18"
                     /gene="GSTM16"
                     /partial
                     /product="glutathione S-transferase"
                     /codon_start=1
                     /translation="MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRT
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLV
                     YDVLDLHRIFEPNCLDAFPNLKDFISRFE"
BASE COUNT      539 a    690 c    754 g    684 t
ORIGIN      
        1 atgcccatga tactggggta ctgggacatc cgtggggtaa gcgagggtcc tctggtgggt
       61 gggacagggg gcggaggcgg ggatgtgtgg agtagctgca ggactggctc tagggaccgt
      121 tcctcttcag ggctgcccgc ctcagaaggg cctgtgcatg acgctgtgtg tgtgtttggg
      181 ggtgggggcg ggtagaggag gcgacgggta cgtgcagtat agactagggc tggcctggtg
      241 cagagaaagt caccaagtca gggaccctcc atctctgacc cgagccgcgg ccatctctcc
      301 cagctggccc acgccatccg cctgctcctg gaatacacag actcaagcta cgaggaaaag
      361 aagtatacga tgggggacgg taatgacacc cttgtgtccg ggctctgcac tcacgctgag
      421 ttggcaccaa gcaacccatg gtggccacct gtcgtacctc tgcaggcctc ccctgctgga
      481 gctgcaggct gtcccttccc tgagccccgg tgaggagtcc tgtggccttg caaggcagaa
      541 tgctggggcg ggatagtggg tccctgttta attgggttgg gtgtcctcag agcttcccaa
      601 accctggaag ccttagccgt gtggggtcca gagcctcagc gggattattt gtccctgaac
      661 cctgggatgt gggactgagt ggtcagattc tagatccacc tgtctcaggg atcttgccac
      721 tggttccttg ggagggtccc cggaaggagg gctgggctct ggggaggttt gttttcactt
      781 cttcttcccc acggcagctc ctgactatga cagaacgcag tggctgaatg aaaaattcaa
      841 gctgggcctg gactttccca atgtaggtgc agggggaagg ggcggttttg ggggaaagtg
      901 cgacgtgtct ctgactgcat ctcctctccc cagattagag gtgttcggat caggagtctt
      961 ctgcccaatt cctggttgtc tacacagccc ctgcatgatg ttctgtgtcc cagctcattt
     1021 gttcatgtga cagtatttct atgtcaggcc tgcatgagcg ggcacagtga gtctggtctc
     1081 cccttgcata taggaagggg atgctgggga gcctgctggc cccaactgag cttccccggt
     1141 ttcccatcta tccagctgcc ctacttgatt gatggggctc acaagatcac ccagagcaac
     1201 gccatcttgt gctacattgc ccgcaagcac aacctgtgtg agtgtgggtg gctgcaatgt
     1261 gtggggggaa ggtggcctcc tccttggctg ggctgtgatg ctgagattga gtctgtgttt
     1321 tgtgggtggc aggtggggag acagaagagg agaagattcg tgtggacatt ttggagaacc
     1381 agaccatgga caaccatatg cagctgggca tgatctgcta caatccagaa tttgtgagtg
     1441 tccccagtga gctgcatctg acagagtttg gatttggggc caggactctt gcatcctgca
     1501 cacattggtc ttaagtccct ggtaccattc atcctccaag tgctttccca tcatctagca
     1561 gtatctctac gactccaatg tcatgtcaac aaaagcagag gcaattccca accaacctta
     1621 ggacacgatt ccaggcattc ccagggtaga aatttcagtt cctgtatggt aaagtttgtg
     1681 ttcagaatct ccttcatcag ctctggcctc tgacttctgt cctgggtcat ttctgtcagc
     1741 cagttcacat cacctgcctg ctcctagaat atgcagactc aagtagaaga ctcaggaatg
     1801 taatggcacc ctcgaattgc atcttctcct caacagtttt ctgagtgctg tcattgacat
     1861 gcacagggat ctgcgcatct tcataacaga cagctcagag gcagtcagag ggcctttatt
     1921 cctctccctc cttcctttca acttgaactt ctcatctccc tggaaactag tcaacgttca
     1981 ttgttttctt ctgccacccc attagaagga actttctact ttccctgagc tcccttagtt
     2041 ctttgcatcc ttgattctgc tggtctggat ccagaggctg ccaggtgctt gggcgctcct
     2101 ggggctgacc cagaggctat tgggaggtca gtgaggacag attcagggac agcatctcat
     2161 tcctctctgc cttctgatca gtttagatag ggtctgacac tcagtcagag tctaaaatgc
     2221 tgagtatcca attgaagcct gcactgcccc agttccagac ttggggaaga tggctgcttg
     2281 cccgtgccag cctggccgtc cacagccccg gggaggccac gtctgtgcag ggagcttttg
     2341 tccgagggtg gtgacagctg ttttctgcct caggagaaac tgaagccaaa gtacttggag
     2401 gaactccctg aaaagctaaa gctctactca gagtttctgg ggaagcggcc atggtttgca
     2461 ggaaacaagg taaaggagga gtgatatggg gaatgagatc tgttttgctt cacgtgttat
     2521 ggaggttcca gcccacacat tcttggcctt ctgcagatca cttttgtaga ttttctcgtc
     2581 tatgatgtcc ttgacctcca ccgtatattt gagcccaact gcttggacgc cttcccaaat
     2641 ctgaaggact tcatctcccg ctttgag
//