From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human ornithine aminotransferase mRNA, complete cds.
Date: 5 Nov 92 23:12:17 GMT
Distribution: bionet
Checksum: 56717 5

LOCUS       HUMOATM      2000 bp ss-mRNA            PRI       15-JUN-1989
DEFINITION  Human ornithine aminotransferase mRNA, complete cds.
ACCESSION   M14963
KEYWORDS    ornithine aminotransferase.
SOURCE      Human liver, cDNA to mRNA, clones HOAT[1,3].
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Ramesh,V., Shaffer,M.M., Allaire,J.M., Shih,V.E. and Gusella,J.F.
  TITLE     Investigation of gyrate atrophy using a cDNA clone for human
            ornithine aminotransferase
  JOURNAL   DNA 5, 493-501 (1986)
  STANDARD  full automatic
COMMENT     Draft entry and clean copy sequence for [1] kindly provided by
            V.Ramesh, 27-MAY-1987.  Gyrate atrophy of the choroid and retina is
            an autosomal recessive disease with reduced or absent ornithine
            aminotransferase activity.  No evidence of gene deletion or
            rearrangements in the genes of people with gyrate atrophy was
            detected.  [1] suggests that the defect may be caused by a subtle
            sequence alteration in the mRNA that does not affect its apparent
            size.
FEATURES             Location/Qualifiers
     mRNA            <1..1997
                     /gene="OAT"
     sig_peptide     45..119
                     /gene="OAT"
                     /codon_start=1
     mat_peptide     120..1361
                     /product="ornithine aminotransferase"
                     /gene="OAT"
                     /codon_start=1
     CDS             45..1364
                     /EC_number="2.6.1.13"
                     /product="ornithine aminotransferase"
                     /codon_start=1
                     /translation="MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIF
                     EREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALK
                     SQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTV
                     KGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERA
                     LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL
                     AVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAI
                     AALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWK
                     VCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF"
BASE COUNT      567 a    370 c    443 g    620 t
ORIGIN      1 bp upstream of EcoRI site; chromosome 10q26.
        1 gaattccgct gtcagatctg tggtttttct acttgaagga cacaatgttt tccaaactag
       61 cacatttgca gaggtttgct gtacttagtc gcggagttca ttcttcagtg gcttctgcta
      121 catctgttgc aactaaaaaa acagtccaag gccctccaac ctctgatgac atttttgaaa
      181 gggaatataa gtatggtgca cacaactacc atcctttacc tgtagccctg gagagaggaa
      241 aaggtattta cttatgggat gtagaaggca gaaaatattt tgacttcctg agttcttaca
      301 gtgctgtcaa ccaagggcat tgtcacccca agattgtgaa tgctctgaag agtcaagtgg
      361 acaaattgac cttaacatct agagctttct ataataacgt acttggtgaa tatgaggagt
      421 atattactaa acttttcaac taccacaaag ttcttcctat gaatacagga gtggaggctg
      481 gagagactgc ctgtaaacta gctcgtaagt ggggctatac cgtgaagggc attcagaaat
      541 acaaagcaaa gattgttttt gcagctggga acttctgggg taggacgttg tctgctatct
      601 ccagttccac agacccaacc agttacgatg gttttggacc atttatgccg ggattcgaca
      661 tcattcccta taatgatctg cccgcactgg agcgtgctct tcaggatcca aatgtggctg
      721 cgttcatggt agaaccaatt cagggtgaag caggcgttgt tgttccggat ccaggttacc
      781 taatgggagt gcgagagctc tgcaccaggc accaggttct ctttattgct gatgaaatac
      841 agacaggatt ggccagaact ggtagatggc tggctgttga ttatgaaaat gtcagacctg
      901 atatagtcct ccttggaaag gccctttctg ggggcttata ccctgtgtct gcagtgctgt
      961 gtgatgatga catcatgctg accattaagc caggggagca tgggtccaca tacggtggca
     1021 atccactagg ctgccgagtg gccatcgcag cccttgaggt tttagaagaa gaaaaccttg
     1081 ctgaaaatgc agacaaattg ggcattatct tgagaaatga actcatgaag ctaccttctg
     1141 atgttgtaac tgccgtaaga ggaaaaggat tattaaacgc tattgtcatt aaagaaacca
     1201 aagattggga tgcttggaag gtgtgtctac gacttcgaga taatggactt ctggccaagc
     1261 caacccatgg cgacattatc aggtttgcgc ctccgctggt gatcaaggag gatgagcttc
     1321 gagagtccat tgaaattatt aacaagacca tcttgtcttt ctgagggtag ccagctgttt
     1381 tcagtggtcc ctgggagcca gctggagaca ggtggtcctg taaaagcttt attcctaatg
     1441 tgggcacatt ccactcccat gagtcttcaa aaactttttt tttgaatata tttttttcag
     1501 ttgatacata atagaacaac gtttatgaac ctgccgtttg ctttgtaacg taactaaata
     1561 atgtaatggc atctatattc agttgaagtg ttttgatgtg catgtgtact tcctaaggtg
     1621 aaatgcatct atatacagac agcctctaaa tcaagtcctt cagtataatt gatatatgtt
     1681 tttataattt cctcactggt ataagtgttt catatttgaa aaagttatct ctgggtattg
     1741 cataaaaggc ttcatcttat aaagtgaaat cattgttatt gaattttagg aaggattaat
     1801 ggttaagtgt atataaaata ctaatattaa gtaaacttca tattggccaa caccagggtt
     1861 gtattctatg gatgtcatta ttttgaatta agaattagcg tttaacattc ctaaattgtt
     1921 ttgagtgctt gattataatt tgtaaaaaat gtttattttc aatacttctt taaatttaaa
     1981 ataaagctta tagtttcttc
//