From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: D.melanogaster crumbs protein mRNA, complete cds.
Date: 7 Jan 93 05:46:05 GMT
Distribution: bionet
Checksum: 05466 14

LOCUS       DROCRPA      7207 bp ss-mRNA            INV       06-JAN-1993
DEFINITION  D.melanogaster crumbs protein mRNA, complete cds.
ACCESSION   M33753
KEYWORDS    crumbs protein.
SOURCE      Drosophila melanogaster (strain Oregon R) (library: lambda-gt10)
            3-12 hr embryo cDNA to mRNA.
  ORGANISM  Drosophila melanogaster
            Eukaryota; Animalia; Metazoa; Arthropoda; Uniramia; Insecta;
            Pterygota; Neoptera; Holometabola; Diptera; Brachycera;
            Cyclorrhapha; Schizophora; Drosophiloidea; Drosophilidae.
REFERENCE   1  (bases 1 to 7207)
  AUTHORS   Tepass,U., Theres,C. and Knust,E.
  TITLE     Crumbs encodes an EGF-like protein expressed on apical membranes of
            Drosophila epithelial cells and required for organization of
            epithelia
  JOURNAL   Cell 61, 787-799 (1990)
  STANDARD  full automatic
COMMENT     Draft entry and computer-readable [or printed] sequence for [1]
            kindly submitted by U.Tepab 17-APR-1990.
FEATURES             Location/Qualifiers
     polyA_site      7207
     CDS             212..6652
                     /gene="crumbs"
                     /product="crumbs protein"
                     /codon_start=1
                     /translation="MAKIANASLSQQQKQRQAETATTTTTTVAASVETATTTARSRDR
                     TKSAAQITSHLLKRAISVYSSPQWIPLFILIYLATDVASVAVPTKEAYFNGSTYLRLT
                     TPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPNNRLDV
                     KLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILIL
                     GNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCLNDPCMG
                     HGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPN
                     HSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECAS
                     QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQ
                     CLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCP
                     IDSECVGGKCVCKPGSSGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSMNGTH
                     CYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVD
                     LPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC
                     DSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCID
                     RINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE
                     LNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLER
                     SNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKH
                     GNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANYGG
                     KNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYTCTCENGFQGDKCEKTTTLSMVATS
                     LISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLN
                     KWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTY
                     LGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCP
                     RTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVE
                     TTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELL
                     VKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDA
                     QVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVK
                     VSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAEC
                     RNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERS
                     PLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGG
                     RVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFS
                     TDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARLGDLLLPY
                     FSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQP
                     GFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCH
                     NGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTC
                     TCVPGFEGPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNP
                     CQNGGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCI
                     CQKPYCGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAK
                     EDGPSTTDIAIIVIPVVVVLLLIAGALLGTFLVMARNKRATRGTYSPSAQEYCNPRLE
                     MDNVLKPPPEERLI"
BASE COUNT     1868 a   1864 c   1876 g   1599 t
ORIGIN      Chromosome 95F9-13.
        1 aaaaaaaata aaaataacct gttctaagcc aagtgccgat tgcgcgcgtg tgtgtgtgtg
       61 cgtatgagtg tttgcgtgga gcagagagaa gggagaatgc aattaccaac aacaacaagc
      121 tcaatgagta tcgtttgaat agcaataata tctagccaaa agcaaccctt tccaatacga
      181 aaactcgact tgagccaaca aatcagcgat catggctaaa atcgccaatg cgtcactgtc
      241 gcaacaacaa aaacagcggc aagcagaaac agcaacgacc acaacaacaa cagtggcggc
      301 atcagtagaa acagcaacaa caacagcaag aagtcgagac cgcacgaaaa gcgcagctca
      361 aattacgtcg catttgctca agcgcgccat ttcagtttat tcgtcgcctc aatggatacc
      421 gctcttcata cttatttact tagcaacaga tgtcgcctca gtggcggtgc cgacgaagga
      481 ggcgtacttt aatggctcca cttacctccg cctcaccacg ccgatgccca tttgggatca
      541 ctcggcgatt agtttccgct cgtgccgcgg cggcgagatc ctcgcccagc agtacaacaa
      601 gaactccatt gtaatctcag tgctcaatga ctttctgcaa atctcactgg ctggacccgc
      661 cgtccatggg cccaacaacc ggctggatgt caagctgccc taccaactgc tggacaaccg
      721 ctggcatacg ctgcagttca agtacgagta cggaaatctc tacctgcatg tggatcgcgc
      781 ggcaagcata tttgccaact ccacgtacaa cagtcagttc ctgactaacc aggacattgg
      841 ctacaaggac gccatcttga tactgggaaa ctccttctcc ggttgccttc tggatggacc
      901 aggtctgcaa tttgtgaaca actcgacggt gcagaatgtg gtctttggtc actgtccctt
      961 gaccccgggt ccctgcagcg atcacgatct tttcactcga ctgccagaca acttttgtct
     1021 gaatgatccc tgtatgggcc atggaacctg ctcgtccagt ccagagggat acgaatgtcg
     1081 gtgcacggca cgttactcgg gaaaaaattg ccagaaggac aatggctcgc cgtgtgccaa
     1141 aaatccatgt gagaacggtg gttcctgcct ggagaattcc cgaggggatt accagtgctt
     1201 ctgtgatccc aaccacagtg gtcagcactg cgagacggag gtgaacatcc acccactctg
     1261 ccagacgaac ccctgcctga acaatggagc atgtgtggtg attggcggca gtggagcact
     1321 cacctgcgag tgtcccaaag gatacgctgg tgccaggtgc gaggtggaca cggatgagtg
     1381 cgcctcacag ccgtgtcaga acaacggaag ctgcatagac cgtatcaatg gattcagctg
     1441 cgattgcagc ggcaccggtt acacgggtgc gttctgccag acgaatgtgg atgagtgcga
     1501 caagaatccg tgcctgaacg gcggcagatg cttcgatacc tacggatggt acacctgcca
     1561 gtgtctggat ggttggggcg gcgagatttg tgatcgaccc atgacatgcc agacgcagca
     1621 gtgtttgaac ggtggcacct gcctggacaa gcccatcggc ttccagtgcc tctgtccgcc
     1681 ggagtacact ggtgaactgt gccaaatcgc acccagttgc gcacagcagt gccccatcga
     1741 ttcggagtgc gtaggcggca aatgcgtttg taagccaggc tcatcgggtt acaactgtca
     1801 aacgagcacg ggcgatggag cttctgcttt ggccctgaca cccatcaact gcaatgccac
     1861 caatggaaag tgtctcaatg gaggaacttg ctccatgaac ggaacccact gctattgcgc
     1921 cgtcggctat tcgggagatc gttgcgagaa ggccgagaac tgttcgccac tgaactgcca
     1981 ggaaccgatg gtatgtgtcc agaatcagtg cctctgcccg gagaacaagg tgtgcaacca
     2041 gtgcgccaca caaccgtgcc agaatggcgg tgaatgtgtg gacctaccga atggagacta
     2101 cgagtgcaag tgcacccgtg gatggactgg acgcacctgt ggcaacgacg tggacgagtg
     2161 caccctgcat ccgaagatct gcggcaatgg tatctgcaag aacgagaagg gatcgtacaa
     2221 atgctactgt acgcctggat ttaccggagt ccactgcgat tccgatgtgg acgaatgcct
     2281 tagctttccc tgcctcaacg gagccacgtg ccacaacaag ataaatgcct acgagtgcgt
     2341 ttgccaacca ggatatgagg gagagaactg cgaagtagat atcgatgagt gcggcagtaa
     2401 tccctgctcg aacggatcca cctgcatcga caggatcaac aacttcacct gcaactgcat
     2461 tccgggaatg acgggccgca tatgtgacat cgacattgac gactgtgtgg gagatccctg
     2521 cttgaatggt ggtcagtgca tcgaccaatt gggtggcttc cgttgtgact gcagtggcac
     2581 cggttatgag ggcgagaatt gtgagctgaa catagacgaa tgcctctcga atccgtgcac
     2641 gaatggtgcc aagtgcctgg acagggttaa ggactacttc tgcgattgcc acaacggcta
     2701 caagggaaag aactgtgagc aggacatcaa cgagtgcgag agtaatccct gccagtacaa
     2761 tggcaactgc ctagagcgtt cgaacataac gctttaccaa atgagtagga tcacggatct
     2821 gcccaaggtg tttagccagc cctttagctt tgagaatgcc agcggctacg agtgcgtctg
     2881 tgtgcccggc atcattggaa agaactgcga gatcaacatt aatgagtgcg acagtaatcc
     2941 atgcagcaag cacggaaatt gcaatgacgg gattggaacc tatacctgcg aatgcgaacc
     3001 tggcttcgag ggcacccact gtgagatcaa catagatgaa tgtgatcgct ataatccctg
     3061 ccagaggggc acttgctatg accagataga cgactacgac tgcgactgcg atgcgaacta
     3121 tggaggcaaa aactgttccg ttcttctcaa aggctgtgac cagaatcctt gtttaaatgg
     3181 cggtgcctgc ttgccgtatt tgatcaacga ggtaactcat ctgtacacct gcacctgcga
     3241 gaacggcttc cagggcgata aatgcgaaaa gaccactact ctgtccatgg tggccactag
     3301 cctgatttcg gttaccacgg aacgcgagga aggctacgac attaatcttc aatttaggac
     3361 cacactgccc aacggagttt tggctttcgg aaccaccggc gaaaagaatg aaccagttag
     3421 ctatattttg gagctgatta atggacgact gaatctacat tcctcgctcc taaataagtg
     3481 ggagggcgtg tttattggat cgaagctgaa cgatagcaac tggcacaagg tgtttgtggc
     3541 cataaacact tcgcatctag tcctttcggc caacgacgag caggctattt ttccggttgg
     3601 ctcctatgaa acggccaata atagccagcc ttcattcccg cgcacatacc tcggaggcac
     3661 cattcccaat ctgaagtcct atctgcgcca cctcacccac caaccatcag cttttgtggg
     3721 ctgcatgcaa gatataatgg tcaatggtaa atggatcttt cccgatgagc aggatgcgaa
     3781 tatcagttat accaaactgg aaaatgtcca gagcggttgt ccgcgcaccg aacaatgtaa
     3841 accgaatcct tgccattcga acggtgaatg cacggacctt tggcacacct tcgcttgtca
     3901 ctgtcccaga ccattctttg ggcacacatg tcagcacaat atgactgctg ccacttttgg
     3961 ccacgagaac acaacccatt cggccgtgat tgtggagacc acagatgtgg ctaggcgagc
     4021 tattagatcc atcctagaca tttccatgtt tattcgtaca cgcgagccaa ctggtcaagt
     4081 cttttacttg ggcactgatc cacgcaaagc ccccactaaa aatattggcg actcatatgt
     4141 ggcggccaaa ttacacggcg gcgagctgct ggtaaagatg cagttcagcg gtactccgga
     4201 ggcctacacc gttggtggcc agaaattgga caacggctat aaccacctga tcgaggtggt
     4261 gcgcaatcaa acgctcgtgc aggtcaagct caatggcacc gagtacttcc gcaagacgct
     4321 gtccacgacg ggtctgctgg acgcacaggt gctttacttg ggcggacctg cacccacacg
     4381 cgagtcactt ctgggcgcga ccacagaacc aggaataatt ccagttccgg gagcaggaat
     4441 acccattgaa gacacaacag tgcccaagga ggcggacgac agcagggact actttaaggg
     4501 cataatccag gacgtgaagg ttagcaatgg ctcgctcaac ctgattgtgg agatgtattc
     4561 cctaaacgtg acagatgtcc aagtgaatgc caaacctctg ggcgctgtaa ccatcgatcg
     4621 tgcctccgtg ttacctggtg aggtgtccga tgatctgtgc cgaaagaatc cctgcctcca
     4681 taatgccgag tgcaggaaca catggaatga ctacacttgc aaatgcccaa atggttacaa
     4741 gggaaagaac tgccaggaga tcgaattttg ccaacacgtt acatgtccgg gacagagctt
     4801 gtgccaaaat ctggacgatg gctatgagtg tgttacgaac accacattta ctgggcagga
     4861 acgcagtcct ctcgccttct tctacttcca ggagcagcaa tctgacgata ttgtcagtga
     4921 agcgtctccc aagcaaactc ttaaaccggt aattgatatt gccttccgca ctcgtgctgg
     4981 aggtactctc ctgtacatag acaatgtgga cggattcttt gaaattggag taaacggagg
     5041 acgagtgacc atcacctgga agctaagtgc actgcatttt ggcgagtctg cacgctttga
     5101 gaaggagaac actgacggag aatggagtcg catttacctc agggcacaca acagcaaact
     5161 ggagggtgga tggaagggat gggaatcgat ggtggatccg acgccagctt tttccacgga
     5221 catcgaccaa gcggccttcc agtccctgat cgctacaagt acccaggttt acttgggtgg
     5281 catgccagag tcgcgacaag cacgaggatc cactttgtct gcccagcagg gctctcagtt
     5341 caagggctgt gtgggagagg caaggctcgg cgatctttta ctgccctact tctccatggc
     5401 ggaactgtat tcgcgcacca atgtttcagt acagcaaaag gctcaattcc gtctaaatgc
     5461 cacacgacct gaggagggct gcatcctgtg cttccagtca gactgcaaaa atgacggctt
     5521 ctgtcaatct ccttcagatg agtacgcctg cacctgtcag cctggattcg agggcgatga
     5581 ttgcggcacg gacatcgacg agtgtcttaa cacggaatgc ttgaacaacg gcacctgcat
     5641 caaccaggtt gcagctttct tctgccagtg tcagccagga ttcgagggtc agcactgtga
     5701 gcaaaacatc gacgagtgtg cggatcagcc gtgccacaac ggtggcaact gcacggatct
     5761 tatcgcatcg tacgtgtgcg actgccctga ggactatatg ggcccgcagt gcgacgtgct
     5821 gaagcaaatg acctgcgaga acgagccatg tcggaatgga tcaacctgcc agaatggatt
     5881 caatgcttct actggcaata actttacatg tacatgcgtg cccggcttcg agggtccact
     5941 gtgtgacata cccttctgtg aaataacgcc ttgcgataac ggtggcctct gcctgaccac
     6001 tggagcggta ccgatgtgca aatgtagtct gggatacact ggtcgcctgt gcgagcagga
     6061 cattaacgag tgcgaatcga atccatgcca gaacggtggt cagtgtaagg acctcgtcgg
     6121 caggtacgag tgcgattgcc agggcaccgg attcgagggc attcgctgtg aaaatgacat
     6181 cgacgagtgc aacatggagg gagattactg cggcggattg ggccggtgtt tcaacaagcc
     6241 cggatccttc cagtgcatct gccagaaacc ctattgcgga gcctactgca actttacgga
     6301 tccctgcaac gctacggacc tctgctcaaa cggcggtcgc tgcgtagagt cctgcggcgc
     6361 caaaccggac tactactgcg agtgtccgga aggtttcgcg ggaaagaatt gcacagcacc
     6421 gattacggcc aaggaggacg ggccttcgac cacagacatt gccatcattg taatacccgt
     6481 agtggtggtg ctgctgctga tcgcgggagc cctcctgggc accttcctgg tgatggccag
     6541 gaacaagcga gcaaccaggg gcacctatag cccgagcgcg caagagtact gcaacccacg
     6601 gctggaaatg gacaacgtac tgaagccacc gccggaagag cgactaattt agttttgagt
     6661 tttgagcatg aacgacgatt agcaaagcaa acaaaagata tttttaaatc cgcccatata
     6721 cacctagctg taggagtaac tcaatgtttt gtactaagtt ggcccctagt tatggtttac
     6781 atcttaaggt gctcaaagca atagcagcag cagcagcagc caggcttcca cctcgactcg
     6841 tcccttatcc cctgcctacg ctttagttag ttaataatgc cgttgtctat ttattctagt
     6901 agtttagatg acatacgtac cgccctatag tcgttatgta gttatgttcc gatagtttag
     6961 attcagtatt cgatttctcg tatatgtaat cctaaagctg cgaacaaagt tgagctccga
     7021 actgtcgatt tcccctttgc attccacaag gaagcccatc aaatgtattg tatgagtatt
     7081 tttgtaaata agattgtttg ccgactctta aactaaatta gctgagctaa aatcgaaatt
     7141 aaaaacagaa aatcctatat gcctatatat acgcgagtat atatatcagt aaatgtggcc
     7201 ttataac
//