From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse meprin A alpha-subunit (MEP-1) mRNA, complete cds.
Date: 21 Jul 92 10:07:19 GMT
Distribution: bionet
Checksum: 04677     7

LOCUS       MUSMEPRINA   2466 bp ss-mRNA            ROD       21-JUL-1992
DEFINITION  Mouse meprin A alpha-subunit (MEP-1) mRNA, complete cds.
ACCESSION   M74897 M74238
KEYWORDS    astacin; meprin A; metalloendopeptidase.
SOURCE      Mus musculus (strain BALB/c, sub_species domesticus) (library:
            lambda-gt10/11 and lambda-ZAPII) kidney cDNA to mRNA; Mus musculus
            (strain CD-1) (library: lambda-gt10/11 and lambda-ZAPII) kidney
            cDNA to mRNA; and Mus musculus (strain C57BL/6) (library:
            lambda-gt10/11 and lambda-ZAPII) kidney cDNA to mRNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (sites)
  AUTHORS   Dumermuth,E., Sterchi,E.E., Jiang,W., Wolz,R.L., Bond,J.S.,
            Flannery,A.V. and Beynon,R.J.
  TITLE     The astacin family of metalloendopeptidases
  JOURNAL   J. Biol. Chem. 266, 21381-21385 (1991)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Jiang,W., Gorbea,C.M., Flannery,A.V., Beynon,R.J., Grant,G.A. and
            Bond,J.S.
  TITLE     The alpha subunit of meprin A: Molecular cloning and sequencing,
            differential expression in inbred mouse strains, and evidnece for
            divergent evolution of the alpha and beta subunits
  JOURNAL   J. Biol. Chem. 267, 9185-9193 (1992)
  STANDARD  simple staff_entry
COMMENT     J. Biol. Chem. 266, 21381-21385 (1991) reports a partial span of
            M74897 from nucleotide 244 to 840.
FEATURES             Location/Qualifiers
     CDS             16..2298
                     /EC_number="3.4.24.18"
                     /product="meprin A alpha-subunit"
                     /gene="MEP-1"
                     /codon_start=1
                     /translation="MARRLGRSSSFAIMLWIQPACLLSLIFSAHIAAVSIKHLLNGSD
                     HDTDVGEQKDIFEINLAAGLNLFQGDILLPRTRNAMRDPSSRWKLPIPYILADNLELN
                     AKGAILHAFEMFRLKSCVDFKPYEGESSYIIFQKLSGCWSMIGDQQVGQNISIGEGCD
                     FKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPY
                     DYESLMHYGPFSFNKNESIPTITTKIPEFNTIIGQLPDFSAIDLIRLNRMYNCTATHT
                     LLDHCDFEKTNVCGMIQGTRDDADWAHGDSSQPEQVDHTLVEQCKGAGYFMFFNTSLG
                     ARGEAALLESRILYPKRKQQCLQFFYKMTGSPADRFEVWVRRDDNAGKVRQLAKIQTF
                     QGDSDHNWKIAHVTLNEEKKFRYVFLGTKGDPGNSSGGIYLDDITLTETPCPAGVWTI
                     RNISQILENTVKGDKLVSPRFYNSEGYGVGVTLYPNGRITSNSGLLGLTFHLYSGDND
                     AILEWPVENRQAIMTILDQEADTRNRMSLTLMFTTSKNQTSSAINGSVIWDRPSKVGV
                     YDKDCDCFRSLDWGWGQAISHQLLKRRNFLKGDSLIIFVDFKDLTHLNRTEVPASARS
                     TMPRGLLLQGQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQ
                     YFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAFFYAGERCQAMHVHGSLLGLLIGCI
                     AGLIFLTFVTFSTTNGKLRQ"
     sig_peptide     16..114
                     /gene="MEP-1"
                     /codon_start=1
     misc_feature    115..246
                     /note="pro-sequence"
                     /gene="MEP-1"
     mat_peptide     247..2295
                     /EC_number="3.4.24.18"
                     /product="meprin A alpha-subunit"
                     /gene="MEP-1"
                     /codon_start=1
BASE COUNT      644 a    624 c    610 g    588 t
ORIGIN
        1 gtccaatagg tttttatggc aaggaggctt ggcagatcca gttcatttgc aataatgctt
       61 tggatacaac ctgcgtgtct tctctcactg attttttctg cccacatagc agctgtatcg
      121 attaagcatc ttttgaatgg atctgatcac gatacagatg ttggtgaaca gaaggatatt
      181 ttcgaaatca atttagctgc aggcctgaac ctctttcaag gggacatcct tctgcccaga
      241 accagaaatg ccatgcgaga tccctcaagc agatggaagc tccccattcc atacattctg
      301 gctgacaatc tggagctgaa tgccaaagga gccatcctcc atgcctttga gatgttccgc
      361 ctcaagtctt gtgtggattt caagccctac gaaggggaga gttcgtatat catcttccag
      421 aaactttctg ggtgctggtc tatgattggt gatcaacagg tgggacagaa catttccatt
      481 ggtgagggat gtgactttaa ggccaccatt gaacatgaaa tcctgcatgc tctgggattc
      541 ttccatgagc agtcaaggac tgaccgggat gattatgtga acatttggtg ggatcaaatc
      601 attacagact atgaacataa tttcaacaca tatgacgaca acaccatcac agacctcaac
      661 acaccctatg attatgagtc cctgatgcac tacgggccat tttcgtttaa caagaacgaa
      721 agcatcccta ccattactac caagatccct gagtttaaca ccatcattgg acaactcccg
      781 gacttcagtg ccattgatct aataagactg aatcgaatgt acaactgcac cgcaacacat
      841 actctgttgg accactgtga ctttgagaag accaacgtct gtgggatgat ccagggaacc
      901 agagatgatg ctgattgggc tcatggggac agcagtcagc ctgaacaagt ggatcacacc
      961 ttggtggaac agtgtaaagg tgccggctac ttcatgttct tcaataccag cttgggggca
     1021 agaggagagg cagcccttct ggagtctcga atcctttatc ccaagaggaa gcagcagtgt
     1081 ttgcagtttt tttataagat gactggaagc cctgcagaca gatttgaagt ctgggtgaga
     1141 agggacgaca acgcgggcaa ggtgcgacag ctggccaaga tccagacctt tcaaggagac
     1201 tctgatcaca actggaaaat tgctcatgtg acactcaatg aagaaaagaa atttcgctat
     1261 gttttcctgg gtaccaaagg ggaccctggt aactcaagtg gtggtattta ccttgatgac
     1321 atcactctga cagaaacccc ctgccctgca ggggtttgga ccatccggaa tatctcccag
     1381 atccttgaga acacagtgaa aggggacaag ctcgtgagcc ctcggttcta caattctgag
     1441 ggttacggtg tgggggtgac cttgtacccc aatggtagaa tcaccagtaa ctctggctta
     1501 ctgggactca cttttcactt gtacagtggg gataacgatg cgattctgga gtggccagtg
     1561 gaaaacagac aggccataat gaccatcctg gaccaggaag ctgataccag gaacaggatg
     1621 tccctgacct tgatgttcac tacctccaag aaccaaacat cttcagctat aaatggctct
     1681 gtcatctggg acaggccatc caaggtggga gtctatgata aggactgtga ttgtttcaga
     1741 agccttgact ggggctgggg tcaggccatc tcccaccagc tgctgaagag aagaaatttt
     1801 cttaaaggcg acagcctcat cattttcgtg gactttaaag acctcaccca cctgaaccgg
     1861 actgaagttc cagcttcagc cagaagcacg atgcccagag gcctccttct gcaaggccag
     1921 gagtctcctg ccttgggaga aagctccaga aaagccatgc tggaggaatc cctgccaagc
     1981 agcctgggcc agagacatcc cagcagacag aagcgctcgg tggagaacac tggccccatg
     2041 gaggaccaca actggccaca gtacttcaga gacccctgtg acccaaaccc ttgccagaat
     2101 gaaggcacct gtgtgaacgt aaagggaatg gccagctgca ggtgcgtctc tgggcacgcc
     2161 tttttctacg caggggagcg ctgtcaggcc atgcacgtgc acggcagctt gctgggcctg
     2221 ctcattggct gcatcgctgg cttgatcttc ttgaccttcg tcacattctc taccaccaac
     2281 ggaaagctgc ggcagtgagc agctacccgc ggatgtccac ccagactttc cttcctgtgg
     2341 tcagaacact ctgggggtag ttttcatcaa acatgttgag agggcctcca aagccaaagc
     2401 cccaaacctc ctgcggggtt ctggccactc catccctgta cagttctgct atgcttctgc
     2461 gaattc
//