From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens skeletal muscle voltage-dependent sodium channel alpha
Date: 29 Dec 92 01:28:13 GMT
Distribution: bionet
Checksum: 04086 14

LOCUS       HUMSKM1A     7823 bp ss-mRNA            PRI       08-DEC-1992
DEFINITION  Homo sapiens skeletal muscle voltage-dependent sodium channel alpha
            subunit (SkM1) mRNA, complete cds.
ACCESSION   M81758
KEYWORDS    transmembrane protein;
            voltage-dependent sodium channel alpha subunit.
SOURCE      Homo sapiens adult skeletal muscle cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 7823)
  AUTHORS   George,A.L., Komisarof,J., Kallen,R.G. and Barchi,R.L.
  TITLE     Primary structure of the adult human skeletal muscle
            voltage-dependent Na+ channel
  JOURNAL   Ann. Neurol. 31, 131-137 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     5'UTR           1..77
                     /gene="SkM1"
     3'UTR           5589..7823
                     /gene="SkM1"
     CDS             78..5588
                     /gene="SkM1"
                     /note="tetrodoxin-sensitive isoform; wild-type sequence of
                     the hyperkalemic periodic paralysis gene;
                     voltage-dependent"
                     /product="sodium channel alpha subunit"
                     /codon_start=1
                     /translation="MARPSLCTLARLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQ
                     MEIEEPERKPRSDLEAGKNLPMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAI
                     FRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNV
                     EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISAL
                     RTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNL
                     RQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATND
                     TFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPKGYECIKTGRNPNYGYTSYDTF
                     SWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAY
                     AEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNG
                     SLDTSQGEKGAPRQSGSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWDCCAPWLK
                     FKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAE
                     MVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKS
                     WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLP
                     RWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL
                     ALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIML
                     SLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNF
                     INNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKP
                     PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEH
                     NWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYG
                     FKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGM
                     RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVN
                     NKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQ
                     PQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYY
                     NAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQS
                     QLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDL
                     IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF
                     IYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPD
                     CDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSE
                     PLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPM
                     VPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKH
                     EEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHEN
                     GNSSSPSPEEKGEAGDAGPTMGLMPISPSDTAWPPAPPPGQTVRPGVKESLV"
BASE COUNT     1621 a   2354 c   2147 g   1701 t
ORIGIN      Chromosome 17q23.1-25.3
        1 ccagcacccc ggggctgcgc actgcagctc cccaggccac ccaccaccct tctggtctct
       61 gagcccagga tgcgaggatg gccagaccat ctctgtgcac cctggctcgt ctgggccctg
      121 agtgcttgcg ccccttcacc cgggagtcac tggcagccat agaacagcgg gcggtggagg
      181 aggaggcccg gctgcagcgg aataagcaga tggagattga ggagcccgaa cggaagccac
      241 gaagtgactt ggaggctggc aagaacctac ccatgatcta cggagacccc ccgccggagg
      301 tcatcggcat ccccctggag gacctggatc cctactacag caataagaag accttcatcg
      361 tactcaacaa gggcaaggcc atcttccgct tctccgccac acctgctctc tacctgctga
      421 gccccttcag cgtagtcagg cgcggggcca tcaaggtgct catccatgcg ctgttcagca
      481 tgttcatcat gatcaccatc ttgaccaact gcgtattcat gaccatgagt gacccgcctc
      541 cctggtccaa gaatgtggag tacaccttca cagggatcta cacctttgag tccctcatca
      601 agatactggc ccgaggcttc tgtgtcgacg acttcacatt cctccgggac ccctggaact
      661 ggctggactt cagtgtcatc atgatggcgt acctgacaga gtttgtggac ttgggcaaca
      721 tctcagccct gaggaccttc cgggtgctgc gggccctcaa aaccatcacg gtcatcccag
      781 ggctgaagac gatcgtgggg gccctgatcc agtcggtgaa gaagctgtcg gatgtgatga
      841 tcctcactgt cttctgcctg agcgtctttg cgctggtagg actgcagctc ttcatgggaa
      901 acctgaggca gaagtgtgtg cgctggcccc cgccgttcaa cgacaccaac accacgtggt
      961 acagcaatga cacgtggtac ggcaatgaca catggtatgg caatgagatg tggtacggca
     1021 atgactcatg gtatgccaac gacacgtgga acagccatgc aagctgggcc accaacgata
     1081 cctttgattg ggacgcctac atcagtgatg aagggaactt ctacttcctg gagggctcca
     1141 acgatgccct gctctgtggg aacagcagtg atgctgggca ctgccctaag ggttatgagt
     1201 gcatcaagac cgggcggaac cccaactatg gctacaccag ctatgacacc ttcagctggg
     1261 ccttcttggc tctcttccgc ctcatgacac aggactattg ggagaacctc ttccagctga
     1321 cccttcgagc agctggcaag acctacatga tcttcttcgt ggtcatcatc ttcctgggct
     1381 ctttctacct catcaatctg atcctggccg tggtggccat ggcatatgcc gagcagaatg
     1441 aggccaccct ggccgaggat aaggagaaag aggaggagtt tcagcagatg cttgagaagt
     1501 tcaaaaagca ccaggaggag ctggagaagg ccaaggccgc ccaagctctg gaaggtgggg
     1561 aggcagatgg ggacccagcc catggcaaag actgcaatgg cagcctggac acatcgcaag
     1621 gggagaaggg agccccgagg cagagcggca gcggagacag cggcatctcc gacgccatgg
     1681 aagaactgga agaggcccac caaaagtgcc caccatggtg gtacaagtgc gcccacaaag
     1741 tgctcatatg ggactgctgc gccccgtggc tgaagttcaa gaacatcatc cacctgatcg
     1801 tcatggaccc gttcgtggac ctgggcatca ccatctgcat cgtgctcaac accctcttca
     1861 tggccatgga acattacccc atgacggagc actttgacaa cgtgctcact gtgggcaacc
     1921 tggtcttcac aggcatcttc acagcagaga tggttctgaa gctgattgcc atggacccct
     1981 acgagtattt ccagcagggt tggaatatct tcgacagcat catcgtcacc ctcagcctgg
     2041 tagagctagg cctggccaac gtacagggac tgtctgtgct acgctccttc cgtctgctgc
     2101 gggtcttcaa gctggccaag tcgtggccaa cgctgaacat gctcatcaag atcattggca
     2161 attcagtggg ggcgctgggt aacctgacgc tggtgctggc tatcatcgtg ttcatcttcg
     2221 ccgtggtggg catgcagctg tttggcaaga gctacaagga gtgcgtgtgc aagattgcct
     2281 tggactgcaa cctgccgcgc tggcacatgc atgatttctt ccactccttc ctcatcgtct
     2341 tccgcatcct gtgcggggag tggatcgaga ccatgtggga ctgcatggag gtggccggcc
     2401 aagccatgtg cctcaccgtc ttcctcatgg tcatggtcat cggcaatctt gtggtcctga
     2461 acctgttcct ggctctgctg ctgagctcct tcagcgccga cagtctggca gcctcggatg
     2521 aggatggcga gatgaacaac ctgcagattg ccatcgggcg catcaagttg ggcatcggct
     2581 ttgccaaggc cttcctcctg gggctgctgc atggcaagat cctgagcccc aaggacatca
     2641 tgctcagcct cggggaggct gacggggccg gggaggctgg agaggcgggg gagactgccc
     2701 ccgaggatga gaagaaggag ccgcccgagg aggacctgaa gaaggacaat cacatcctga
     2761 accacatggg cctggctgac ggccccccat ccagcctcga gctggaccac cttaacttca
     2821 tcaacaaccc ctacctgacc atacaggtgc ccatcgcctc cgaggagtcc gacctggaga
     2881 tgcccaccga ggaggaaacc gacactttct cagagcctga ggatagcaag aagccgccgc
     2941 agcctctcta tgatgggaac tcgtccgtct gcagcacagc tgactacaag ccccccgagg
     3001 aggaccctga ggagcaggca gaggagaacc ccgaggggga gcagcctgag gagtgcttca
     3061 ctgaggcctg cgtgcagcgc tggccctgcc tctacgtgga catctcccag ggccgtggga
     3121 agaagtggtg gactctgcgc agggcctgct tcaagattgt cgagcacaac tggttcgaga
     3181 ccttcattgt cttcatgatc ctgctcagca gtggggctct ggccttcgag gacatctaca
     3241 ttgagcagcg gcgagtcatt cgcaccatcc tagaatatgc cgacaaggtc ttcacctaca
     3301 tcttcatcat ggagatgctg ctcaaatggg tggcctacgg ctttaaggtg tacttcacca
     3361 acgcctggtg ctggctcgac ttcctcatcg tggatgtctc catcatcagc ttggtggcca
     3421 actggctggg ctactcggag ctgggaccca tcaaatccct gcggacactg cgggccctgc
     3481 gtcccctgag ggcactgtcc cgattcgagg gcatgagggt ggtggtgaac gccctcctag
     3541 gcgccatccc ctccatcatg aatgtgctgc ttgtctgcct catcttctgg ctgatcttca
     3601 gcatcatggg tgtcaacctg tttgccggca agttctacta ctgcatcaac accaccacct
     3661 ctgagaggtt cgacatctcc gaggtcaaca acaagtctga gtgcgagagc ctcatgcaca
     3721 caggccaggt ccgctggctc aatgtcaagg tcaactacga caacgtgggt ctgggctacc
     3781 tctccctcct gcaggtggcc accttcaagg gttggatgga catcatgtat gcagccgtgg
     3841 actcccggga gaaggaggag cagccgcagt acgaggtgaa cctctacatg tacctctact
     3901 ttgtcatctt catcatcttt ggctccttct tcaccctcaa cctcttcatt ggcgtcatca
     3961 ttgacaactt caaccagcag aagaagaagt taggggggaa agacatcttt atgacggagg
     4021 aacagaagaa atactataac gccatgaaga agcttggctc caagaagcct cagaagccaa
     4081 ttccccggcc ccagaacaag atccagggca tggtgtatga cctcgtgacg aagcaggcct
     4141 tcgacatcac catcatgatc ctcatctgcc tcaacatggt caccatgatg gtggagacag
     4201 acgaccagag ccagctcaag gtggacatcc tgtacaacat caacatgatc ttcatcatca
     4261 tcttcacagg ggagtgcgtg ctcaagatgc tcgccctgcg ccagtactac ttcaccgttg
     4321 gctggaacat ctttgacttc gtggtcgtca tcctgtccat tgtgggcctt gccctctctg
     4381 acctgatcca gaagtacttc gtgtcaccca cgctgttccg tgtgatccgc ctggcgcgga
     4441 ttgggcgtgt cctgcggctg atccgcgggg ccaagggcat ccggacgctg ctgttcgccc
     4501 tcatgatgtc gctgcctgcc ctcttcaaca tcggcctcct cctcttcctg gtcatgttca
     4561 tctactccat cttcggcatg tccaactttg cctacgtcaa gaaggagtcg ggcatcgatg
     4621 atatgttcaa cttcgagacc ttcggcaaca gcatcatctg cctgttcgag atcaccacgt
     4681 cggccggctg ggacgggctc ctcaacccca tcctcaacag cgggccccca gactgtgacc
     4741 ccaacctgga gaacccgggc accagtgtca agggtgactg cggcaacccc tccatcggca
     4801 tctgcttctt ctgcagctat atcatcatct ccttcctcat cgtggtcaac atgtacatcg
     4861 ccatcatcct ggagaacttc aatgtggcca cagaggagag cagcgagccc cttggtgaag
     4921 atgactttga gatgttctac gagacatggg agaagttcga ccccgacgcc acccagttca
     4981 tcgcctacag ccgcctctca gacttcgtgg acaccctgca ggaaccgctg aggattgcca
     5041 agcccaacaa gatcaagctc atcacactgg acttgcccat ggtgccaggg gacaagatcc
     5101 actgcctgga catcctcttt gccctgacca aagaggtcct gggtgactct ggggaaatgg
     5161 acgccctcaa gcagaccatg gaggagaagt tcatggcagc caacccctcc aaggtgtcct
     5221 acgagcccat caccaccacc ctcaagagga agcacgagga ggtgtgcgcc atcaagatcc
     5281 agagggccta ccgccggcac ctgctacagc gctccatgaa gcaggcatcc tacatgtacc
     5341 gccacagcca cgacggcagc ggggatgacg cccctgagaa ggaggggctg cttgccaaca
     5401 ccatgagcaa gatgtatggc cacgagaatg ggaacagcag ctcgccaagc ccggaggaga
     5461 agggcgaggc aggggacgcc ggacccacta tggggctgat gcccatcagc ccctcagaca
     5521 ctgcctggcc tcccgcccct cccccagggc agactgtgcg cccaggtgtc aaggagtctc
     5581 ttgtctagca ggcagcatcg gggtggcccc actgagtctc ggcatagtcc ccagagctcc
     5641 cccgtggtgc ctgcacacag agtgagggag gagggctttg aatctgggac tgtgcctggc
     5701 tccctgatgg gggacaggat ttggccacac tggggctgac acccaggccc gagcgcctgc
     5761 gttcccagac catgggaaat gggaattgcg ctcaggggct ccatgctggg tctgaggccc
     5821 ctgcctccaa gatttaacct gcaagttgct ctgacctcct ctgggccctg tcgcccctcc
     5881 ttttggcctg ggggaggtca gaacattcga atctctgccc ctcacttgag gaggagctgg
     5941 cctgcggtgg agggatcagt tgccccccat caccagagtc ttaagggtca ctggcctctc
     6001 cccaggaagt gggctcagac ccccctcagc cccagcccag acaaagatgt cttaacctca
     6061 gggagtgcag acacctaacc ccagggcact gccagcccac cccctttgac tctggggtgc
     6121 agcttcaccc accaggccag ctcaggaatt ccctggaaaa gggaaatgtg actggttcag
     6181 aaatagctcc tcaaagcctc aaaacctgat tggccactgg atcctgctgc tttgggctgg
     6241 gatggtgact cctgaaacct cttcctaggc cacgtccagg tccgtagctc ccctggctgg
     6301 ctcctagggg aagagcagaa ggaaggatgc cacttgggaa tgaattgtcc ttttctagga
     6361 agcacggggg agtgagacag gctgggtcct gccagctgga tcgctgcaca tggcctgagc
     6421 atccagacct gagcgggagt cagggacctg ctgctcagta agaagattct cgccccttcc
     6481 ctctctccct gcctcactcc tccgtgagca ccaccagggc tccaggagcc tcatccagcc
     6541 tcagagatct cccttctcat ctccccacgc cccgtctctt tctcaccttt cccacctctc
     6601 tccccaaagt gatcctaaga atgtacagtt gagctcaggt tagatatttc gaccctgggg
     6661 cgtgcagcag ggaaggccca actggttcag gctcaacctt ccaacttcct gtggcctgaa
     6721 gaagcacttc tgctgcatcg ctgttctggg catggcaggg ccaggcctct gctggctcag
     6781 gaggaggggt gagagacctg ctcaggcgtc gctggattta ttcacttgtg tgtgtacctg
     6841 tggctgtgtg tctgcttgta tgcttttata ggcctgtgtg tatagctgtg tgtgtgttca
     6901 agtgcgtgac tgtatgtgtg tgtgtgaacc actgtgtgaa ccactgtgta ctggagcctg
     6961 cattatgcac gtgtctgggt atctttgtat atatgtgtat atatgtgtgc cctggactgt
     7021 ttcaaggtcc atggagtacg gctggtgtgt catactgtgc aggcctgtcc ctgggagtgt
     7081 tcccgtgcct gggagagtgg acctgtgctg tgagtgtgtg gatgcgtgtg aacgcatgtg
     7141 gtaaggtgtg tactcagggc attctgttgg cctaagtgcc tcttcttttt cttcttgttt
     7201 ctcatgaaaa gtttgattaa aattcaggaa gcagcaaaac cttcaaaaca agacatgtat
     7261 gtgtgcttga gtgtgtgaac acgtgtgtgt gtgtgcacat ctacatgcca tgcctatggg
     7321 ccagagttgt ctttattgtc caccatgctc tctcacctgc ttcccagtcc tgcctgaaca
     7381 gccctctctc tcactcccct ctcctcccct tcctgtttct cgttgtcaca cccatggcct
     7441 cagccctgct ccctgcctcc tgcctatgtc tcctctatgg aaggaggcct ccactccttc
     7501 catctcttcc ttcagaagtt tcgtctaatg ggggcagtct ccccttcctg gcacattgcc
     7561 cctctgcctt gccctcctgg gccctgggct ggcacagccc ctggagcctc agaaatctgt
     7621 ttgattggat attctcctcg gactgtgtgc aggttgcaga ggaagagtag atgagccggg
     7681 tccggcctct ccctgcctgt ggcccctccc ctgcagacgg atgcccattc ctgcctggtc
     7741 cagtggggaa caggtcccac gccaggccag caggcgggct cctttgtaca gttcttacaa
     7801 taaaccctcc ttggtgcctc tgg
//