From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens iduronate 2-sulfatase (IDS) gene, exon 9 and 5' end of
Date: 6 Nov 92 18:29:54 GMT
Distribution: bionet
Checksum: 03683 3

LOCUS       HUMISS09       76 bp ds-DNA             PRI       02-NOV-1992
DEFINITION  Homo sapiens iduronate 2-sulfatase (IDS) gene, exon 9 and 5' end of
            cds.
ACCESSION   L04586
KEYWORDS    L-iduronate-2-sulfate 2-sulfohydrolase; chondroitinsulfatase;
            iduronate 2-sulfatase; lysosomal enzyme.
SEGMENT     9 of 9
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Wilson,P.J., Morris,C.P., Anson,D.S., Occhiodoro,T., Bielicki,J.,
            Clements,P.R. and Hopwood,J.J.
  TITLE     Hunter syndrome: Isolation of an iduronate-2-sulphatase cDNA clone
            and analysis of patient DNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87, 8531-8535 (1990)
  STANDARD  full automatic
REFERENCE   2  (sites)
  AUTHORS   Flomen,R.H., Green,E.P., Green,P.M., Bentley,D.R. and Giannelli,F.
  TITLE     Determination of the organisation of coding sequences within the
            iduronate sulphate sulphatase (IDS) gene
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     Reference [1] reports bases 61-76; reference [2] reports features
            only.
FEATURES             Location/Qualifiers
     intron          <1..60
                     /note="3'end of intron 8"
                     /gene="IDS"
     exon            61..>76
                     /number=9
                     /gene="IDS"
     mRNA            join(L04578:<1..103,L04579:61..197,L04580:61..238,
                     L04581:22..110,L04583:61..261,L04582:61..231,
                     L04584:61..187,L04585:61..234,61..>76)
                     /gene="IDS"
     CDS             join(L04578:1..103,L04579:61..197,L04580:61..238,
                     L04581:22..110,L04583:61..261,L04582:61..231,
                     L04584:61..187,L04585:61..234,61..>76)
                     /function="lysosomal enzyme"
                     /EC_number="3.1.6.13"
                     /standard_name="L-iduronate-2-sulfate 2-sulfohydrolase"
                     /partial
                     /product="iduronate 2-sulfatase"
                     /codon_start=1
                     /translation="MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIV
                     DDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRL
                     YDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHP
                     SSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASP
                     FFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDV
                     QALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSD
                     HGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLME
                     PGRQSM"
BASE COUNT       14 a     21 c     18 g     23 t
ORIGIN      
        1 gcctggccat ggcaggcttt tataatgtaa cccattctgc tctgtcgctt cctgtttcag
       61 gcaggcaatc catgga
//