From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens gene for parvalbumin
Date: 22 Jul 92 10:03:08 GMT
Distribution: bionet
Checksum: 18208     5

LOCUS       HUMPVALB     1350 bp ds-DNA             PRI       22-JUL-1992
DEFINITION  H.sapiens gene for parvalbumin
ACCESSION   X63578
KEYWORDS    PVALB gene; parvalbumin.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Berchtold,M.W.
  TITLE     Parvalbumin genes from Human and Rat are identical in intron/exon
            organization and contain highly homologous regulatory elements and
            coding sequences
  JOURNAL   J. Mol. Biol. 210, 417-427 (1989)
  STANDARD  full automatic
COMMENT     *source: clone_library=cosmid PNNL; TC; *source: clone=cos
            TCFP-HPV-3; *source: chromosome=22 q12.1-q13;
            From EMBL    entry HSPVALB;  dated 09-JAN-1992.
FEATURES             Location/Qualifiers
     mRNA            join(472..541,566..633,658..790,815..918,943..1157)
     CDS             join(573..633,658..790,815..918,943..971)
                     /product="parvalbumin"
                     /gene="PVALB"
                     /codon_start=1
                     /translation="MSMTDLLNAEDIKKAVGAFSATDSFDHKKFFQMVGLKKKSADDV
                     KKVFHMLDKDKSGFIEEDELGFILKGFSPDARDLSAKETKMLMAAGDKDGDGKIDEFS
                     TLVAES"
     misc_feature    1..472
                     /note="5' flanking region"
     misc_feature    367..398
                     /note="box with high similarityto corresponding region in
                     myosin light chain 3Fpromoter"
                     /note="putative"
     CAAT_signal     422..427
     TATA_signal     448..473
     exon            472..541
                     /number=1
     prim_transcript 472..1157
     intron          542..565
                     /number=1
     exon            566..633
                     /number=2
     intron          634..657
                     /number=2
     exon            658..790
                     /number=3
     intron          791..814
                     /number=3
     exon            815..918
                     /number=4
     intron          919..942
                     /number=4
     exon            943..1157
                     /number=5
     polyA_signal    1139..1144
     misc_feature    1158..1350
                     /note="3'flanking region"
BASE COUNT      326 a    348 c    365 g    311 t
ORIGIN
        1 agcgcaggtc acttacatca atcgaacttt atgctgtttc ctcatctgtg cgagagagct
       61 atgtctacct ggcaaggctg tagtgagaga tcatatcagc ataggaaggg gcatcagccc
      121 atgcacagag gacagttctt gtttcattct tttccttagt atttctcttc ctttcctggc
      181 agaatatgga ggaaggaaga tcgctgccat ctacagtggt cacggaaggc ttcatggaag
      241 aggcgagccc tgcctgggcg tcaatttggg tgctggaggg aagcaggggc caagagttat
      301 taatagtctt gcctgatggg cccagggagg ctgaatgtga tacagacacc cagcaccacg
      361 gttggggagt acctgacacc ggaaggggag ggggtccggg gctacgggga gtgccacctc
      421 ccaaaatagc cgagcagaag cctatatagg tggccatccc tcctccaggc tcacttcccg
      481 acaggacttc ccaccagccc agcctttcag tgcaggctcc agccctccac ccccacccga
      541 ggtgagtggc agcccgctca aacagttgca ggatgtcgat gacagacttg ctgaacgctg
      601 aggacatcaa gaaggcggtg ggagccttta gcggtgagca agcgcttccc cccacagcta
      661 ccgactcctt cgaccacaaa aagttcttcc aaatggtcgg cctgaagaaa aagagtgcgg
      721 atgatgtgaa gaaggtgttt cacatgctgg acaaggacaa aagtggcttc atcgaggagg
      781 atgagctggg gtaagctgga ggtttctcct ccagattcat cctaaaaggc ttctccccag
      841 atgccagaga cctgtctgct aaagaaacca agatgctgat ggctgctgga gacaaagatg
      901 gggacggcaa aattgacggt gggtagccgt tttgttctgc agaattctcc actctggtgg
      961 ctgaaagcta agaagcactg actgcccctg gtcttccacc tctctgccct gaacacccaa
     1021 tctcggcccc tctcgccacc ctcctgcatt tctgttcagt tcgtttatgt tattttttac
     1081 tcccccatcc cctgtggccc tctaatgaca ccattcttct ggaaaatgct ggagaagcaa
     1141 taaaggttgt accagtcaga ctctgcttgc tcaggaagac ccaggcctgg tcaggcattg
     1201 gctttccaga tgcatctggg cagggggtgg gggctggatt tcaacagtta gaaaagttgt
     1261 gataggaggg aatggaaggg aacagtctct tttctgttct aagtactaag catggaactc
     1321 tacagaggtt accacttact cctaaacacc
//