From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Schistosoma mansoni epidermal growth factor receptor (SER,
Date: 21 Aug 92 10:12:50 GMT
Distribution: bionet
Checksum: 65355     6

LOCUS       SCMEGFRB     2424 bp ss-mRNA            INV       21-AUG-1992
DEFINITION  Schistosoma mansoni epidermal growth factor receptor (SER,
            alternative splice class 2 product) mRNA, complete cds.
ACCESSION   M86397
KEYWORDS    EGF receptor; alternative splicing;
            epidermal growth factor receptor; receptor tyrosine kinase.
SOURCE      Schistosoma mansoni (strain Puerto Rican) male adult cDNA to mRNA.
  ORGANISM  Schistosoma mansoni
            Eukaryota; Animalia; Eumetazoa; Platyhelminthes; Trematoda;
            Digenea; Strigeidida; Strigeata; Schistosomatoidea;
            Schistosomatidae.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Shoemaker,C.B., Ramachandran,H., Landa,A., dos Reis,M.G. and
            Stein,L.
  TITLE     Alternative splicing of the Schistosoma mansoni gene encoding a
            homologue of epidermal growth factor receptor
  JOURNAL   Mol. Biochem. Parasitol. 53, 17-32 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             49..1053
                     /note="SER class 2 product, truncated EGF receptor"
                     /product="epidermal growth factor receptor"
                     /gene="SER"
                     /codon_start=1
                     /translation="MNFLLPTLVIIFALNCWSLKFSISEYPWIKACRVWERDCSKPNP
                     KHIQLTYIKFLYGGCTHIIGNLVICGLEKLENGSDPDLSFLEKIEDVSGYVYIGQNSV
                     KTISLPSLKVIRGEPGYRIMNTSAALVISRNSLEILDLRSLTAIQRNDIVALNNQFLC
                     NFGFTIDWEQIFEDNRKQMFIPDRKEKTVSHAGCDIALRKYTDDRTKHSCHGSCPVVN
                     GRGYCWGPKPEMCQKMLKCANNPDNYCLGGRATTQPCLEECLGGCETRPGNCRACKHA
                     MNDGKCVSQCPPPLIVSREESRTVANPEFKYNFHDICVKNCPATTKTELPQFLFHDDP
                     "
     sig_peptide     49..105
                     /gene="SER"
                     /codon_start=1
     mat_peptide     106..1050
                     /note="class 2 product"
                     /gene="SER"
                     /codon_start=1
     misc_feature    1004
                     /note="point of divergence from class 1 product"
                     /gene="SER"
                     /evidence=EXPERIMENTAL
     polyA_site      2410
                     /gene="SER"
                     /evidence=EXPERIMENTAL
BASE COUNT      697 a    511 c    409 g    807 t
ORIGIN
        1 tttggcacgt tttcgaaagt tgatggggtt cgacagaaca attcttaaat gaatttttta
       61 ctacctactc tggttattat tttcgctctt aattgctggt ccttaaaatt ttccatttct
      121 gagtacccat ggattaaagc ctgtcgtgtt tgggagagag actgctcgaa gcctaatcca
      181 aaacatatac agctcactta catcaagttt ttatacggag gttgtactca cataatcggg
      241 aatttggtta tatgcggtct agagaaactt gaaaatggat ccgatcctga tctttctttt
      301 cttgaaaaga ttgaagatgt gtccggttat gtgtacattg gtcaaaacag tgttaaaacg
      361 atatcattac cgtctttgaa agttattcgc ggtgaaccgg gatatcgtat catgaatact
      421 agtgctgcac ttgttattag tcgaaacagt cttgaaatcc tagatttacg aagtttgaca
      481 gccattcaac gcaacgatat tgtagcatta aataatcagt ttttgtgcaa ctttggtttc
      541 acgattgatt gggaacagat ttttgaagac aaccgtaaac aaatgtttat accggatcga
      601 aaagaaaaaa cagtttctca cgccggttgt gatattgctc tacgaaaata cactgatgat
      661 cgtaccaaac attcctgtca tggttcctgt cctgtggtaa atggacgagg ttattgctgg
      721 ggtccaaagc ctgagatgtg tcaaaaaatg ctaaaatgcg ctaacaatcc tgataactat
      781 tgtcttggtg gtagagcgac tacacaacca tgtctggaag aatgcttggg tggatgcgaa
      841 actcgtcctg gcaattgtag agcatgcaaa catgctatga atgatggcaa atgtgtatca
      901 caatgtcctc caccattgat agttagtcga gaagagagta gaactgttgc aaatccagaa
      961 ttcaaatata acttccatga catttgcgtt aaaaattgcc cagcgacaac caaaaccgaa
     1021 cttcctcaat ttttgtttca cgatgatccc tagtttgttc atattatcta ttcatcgaca
     1081 tgtaaatctg aatgctgcat catctattac gcatcaaaaa tattcgatta ctgcaattaa
     1141 tattctattc ccattgcact gtacgccaga acatagagtt tagagctatt ctctcaaaga
     1201 tacactcttg ttcgtcacat ccaagtcagt ctcactcgcc gtcatcgata attatatgta
     1261 ttggtatttt tactatgcct taatacggtt tcgcaacaaa cgaggttgag cgcatatccc
     1321 tctaactaca caaaccacga taggctgcat gaccataaag gaacacgact ccgcatatct
     1381 catctaagca gtcactatcc tgttcctctg gtcattctac taatacatat ttaacgataa
     1441 ctcaacgcaa gcgacaacgc acactgactt ctcattttat tatcattatc aatagcagta
     1501 cagcaatgaa tttcaaccgt tgatgcagtt atcatcctac gactcgatta tttttaccac
     1561 acacgaactc caggtatgca aattcgaatc tactaatcgc tgatcgacgc tatttacttt
     1621 actgcggctt atcggaacat atttcgctgt tctttatcct catattcagt cagcaccaca
     1681 gaccaattac tgttatactc tattttcacg atatttcgat tcgcgcatat gaacatgtta
     1741 ttttatcatt cggacagtca ctacataaat gcatgcatgt taaatttttt tgtacgctta
     1801 ccaatttact cataatcaca tgctagcatt tcaatttttg tccgcatctt gacaatattc
     1861 atgtacattt ttacataagt atgacacttt cgtttaatac gctcacccca cttgacactg
     1921 taatttatca ggtattgcac catttttttc ccacattttg acgttatcca cataccgctt
     1981 cagtgttatt tttcgaaaat agacattttt tttataaatg tgctattttc tacaaggggg
     2041 ctatgtagta tcggttgtta tgttaagccc atatacttta ttctagttgc tggccaagcc
     2101 aattcacctg tacattgagt catcttttga tcttgttaat catttgctta ttaaccttga
     2161 gtacttttta tatgagcgta taggtgtaca cacttcgtat cttattcatc atatgtctgt
     2221 cactcatttt tgcctgacta taaatgttga ctaacgcttg cttaaatcga gttggcttcc
     2281 cagccatctc caatacgcat catctttcgc ctcgctcact cgcttgccgc tcactcgctc
     2341 gttgatattc gctcaggtgt tgttaacttt cgaacctgag ttattcgaca ataaactgta
     2401 gttgctgcta aaaaaaaaaa aaaa
//