From: kristoff@GENBANK.BIO.NET (Dave Kristofferson)
Newsgroups: bionet.sci-resources
Subject: NIH Guide, vol. 21, no. 29, pt. 2, 14 August 1992
Date: 14 Aug 92 23:32:30 GMT
Distribution: bionet


$$XID NIHGUIDE 19920814 V21N29 P2O2 ************************************
the grantee institution.  The funding components' contribution to
salary support is geared to the institution's base as follows:  up to
$45,000 - 100 percent of institutional base; $45,001 to $60,000 -
$45,000; $60,001 and over - 75 percent of institutional base, up to
$75,000.  The grantee institution may supplement the contribution of
the funding component up to a level consistent with the institution's
salary scale.  Fringe benefits are paid out of grant funds in the same
proportion as the salary contribution.

Allowance for Support Costs:  In addition to salary support, funds up
to $50,000 in the aggregate may be requested for each year to support
research and/or career development activities.  Applicants may request
up to eight percent of direct costs for indirect costs.

RESEARCH OBJECTIVES

The NIAAA, NIDA, and NIMH provide an integrated Scientist Development
Award Program that is made up of three types of awards:  the Scientist
Development Awards (K20, K21), the Research Scientist Development Award
(K02), and the Research Scientist Award (K05).  Together they provide
a continuum of support for scientists at several stages of their
careers.  The K20 is designed for beginning individuals trained as
clinicians showing great promise as researchers but requiring further
supervised research experience to become outstanding independent
investigators.

The K20 candidate should address a program of research relevant to the
mission of the funding component.  The trajectory of the candidate's
development as a research scientist is of paramount importance in this
program, and the intent is to assist a person with great potential to
become an outstanding scientist, fully able to function as an
independent investigator.  An individual who holds a K20 grant is
expected to apply for a small grant award, a First Independent Research
Support and Transition (FIRST) award, a traditional research grant, or
any other appropriate grant, providing that eligibility criteria for
the other award(s) and terms and conditions of the K20 are met.

SPECIAL REQUIREMENTS

Individuals must devote full-time (at least 80 percent) to career
development activities, supervised research, developing skill in
research methods, or other research-related activities relevant to
their career goals.  Providing health care is acceptable only when it
is necessary to maintain and enhance skills required for the conduct of
research.  Remuneration for clinical practice, consultation, or work
related to the awardee's research program must be assigned to the
grantee institution and may not be retained by the awardee.

Use of PHS Research or Training Grant Funds Freed by a K20: Funds
budgeted in PHS-supported research or training grants for the salaries
or fringe benefits of individuals, but freed as a result of a K20
award, may not be rebudgeted.  Questions regarding leaves of absence,
change of institution, or transfer of award should be addressed to
appropriate staff of the PHS funding component.

Concurrent Application:  The candidate for a K20 may not concurrently
apply for any other PHS grant, nor may there be another application
pending funding.

STUDY POPULATIONS

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDY POPULATIONS

Applications that involve human subjects are required to include
minorities and both genders in study populations.  This policy applies
to all research involving human subjects and human materials, and
applies to males and females of all ages.

APPLICATION PROCEDURES

Prospective applicants are advised to contact the relevant contact (see
INQUIRIES) for a copy of the complete PA and for information regarding
preapplication consultation and the application process.  The research
grant application kit form PHS 398 (rev. 9/91), is to be used in
applying for the K20.  These forms are available from institutional
offices of sponsored research or their equivalent and from the offices
listed under INQUIRIES.

Special instructions prepared for the K20 are included in the complete
PA.  The title and number of this PA, Scientist Development Award for
Clinicians (PA-92-98), must be typed in Item 2a on the face page of the
application form.  Applications will be accepted on February 1, June 1,
and October 1.  Applications received after these receipt dates are
subject to assignment to the next cycle or may be returned to the
applicant, if so requested by the applicant.

An original and five copies of the completed and signed application are
to be submitted to:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892**

REVIEW CONSIDERATIONS

Review procedures of K20 applications will be the customary system of
dual review:  evaluation for scientific and technical merit by an
initial review group of the appropriate funding component consisting
primarily of non-government scientific experts, followed by evaluation
for policy and program relevance by the appropriate National Advisory
Council.  Only applications recommended for approval by the Council
will be considered for funding.  Applications will be reviewed for the
candidate's potential to develop into a productive alcohol, drug abuse,
and/or mental health researcher.  Reviewers will consider:  (1) the
qualifications of the candidate including the suitability of the
candidate relative to the eligibility criteria and purposes of the K20;
(2) the soundness of the proposed career development plan; (3) the
preceptor and institutional environment including the institution's
commitment to the candidate's career; (4) the nature and
scientific/technical merit of the research plan; and (5) the
appropriateness of the budget.  Detailed review criteria are listed in
the full PA.

AWARD CRITERIA

The responsibility for award decision resides solely with authorized
program staff of the funding components.  The following criteria will
be used in making award decisions:  (1) overall merit of the
application; (2) relevance of the application to the research
priorities of the awarding component and program balance; and (3)
availability of funds.

INQUIRIES

The full PA, which includes the Special Instructions for preparing K20
Applications, up-to-date policy guidelines, and the application forms,
may be obtained from any of the following offices:

National Institute on Alcohol Abuse and Alcoholism
OSAP National Clearinghouse for Alcohol and Drug Information
P.O. Box 2345
Rockville, MD  20847-2345
Telephone:  (301) 468-2600 or 1-(800)-729-6686

National Institute on Drug Abuse
Grants Management Branch
5600 Fishers Lane, Room 8A-54
Rockville, MD  20857
Telephone:  (301) 443-6710

National Institute of Mental Health
Grants Awards and Operations Section
Grants Management Branch
5600 Fishers Lane, Room 7C-05
Rockville, MD  20857
Telephone:  (301) 443-4414

Inquiries regarding grants management may be directed to the National
Institute of Mental Health address given immediately above.

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.271, 93.277, 93.281.  Awards will be made under the authority of
Section 301 of the Public Health Service Act, as amended (42 U.S.C.
241) and administered in accordance with the PHS grants policy
statement revised October 1990.  This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review.

$$P3 END ************************************************************

$$P4 BEGIN PA-92-99 *************************************************

SCIENTIST DEVELOPMENT AWARD

NIH GUIDE, Volume 21, Number 29, August 14, 1992

PA AVAILABLE:  PA-92-99

P.T. 34; K.W. 0404003, 0404009, 0715129

National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institute of Mental Health

THE PROGRAM ANNOUNCEMENT (PA) ANNOUNCED IN THIS NOTICE CONTAINS
ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.  POTENTIAL
APPLICANTS MAY OBTAIN THE PA FROM THE CONTACT NAMED IN INQUIRIES,
BELOW.

PURPOSE

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), the
National Institute on Drug Abuse (NIDA), and the National Institute of
Mental Health (NIMH) provide Scientist Development Awards (SDA) to
eligible applicants early in their careers who need additional
supervised research experience to develop into independent scientists.
The SDA is also available to experienced investigators who require
supervised research experience to enable them to switch fields.  These
awards are intended to make it possible for investigators to engage in
alcohol, drug abuse, and/or mental health related research on a
full-time, long-term basis, and to stimulate recipient institutions to
maintain and expand existing research programs or to establish new ones
for studies in these areas.

The NIAAA, NIDA, and NIMH each have different program goals and
initiatives; therefore, potential applicants must contact the
appropriate office, listed below, prior to preparing an application to
obtain the full Program Announcement (PA) and current information with
regard to the SDA.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Scientist Development Award, is related to the priority areas of mental
health and disorders and alcohol and other drugs.  Potential applicants
may obtain a copy of "Healthy People 2000" (Full Report:  Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1) through
the Superintendent of Documents, Government Printing Office,
Washington, DC  20402-9935 (telephone 202/783-3238).

ELIGIBILITY REQUIREMENTS

Eligible applicant institutions include public and private, non-profit
and for profit organizations and institutions engaged in alcohol, drug
abuse, and/or mental health research that are located in the United
States or its territories and possessions.  These institutions apply on
behalf of a qualified candidate who holds an earned doctorate.  Women
and minority candidates in particular are encouraged to apply.

An individual who has been a Principal Investigator on a Public Health
Service (PHS) research grant or who has had equivalent research support
is not eligible for the SDA.  Recipients of PHS Small Grant Awards are
an exception to this restriction and are eligible to apply.
Experienced investigators applying for an SDA may previously have held
a major PHS research grant or its equivalent; however, any such
previous award must have been in an area substantially different from
the research field in the SDA application.  Persons who hold a position
with firm salary support for full-time research, or those with endowed
chairs, are not eligible.

MECHANISM OF SUPPORT

The mechanism of support is the Scientist Development Award (K21),
which is intended for beginning basic scientists who show great promise
but need supervised research experience to develop into independent
investigators, and for experienced investigators requiring supervised
research in order to switch fields.

The essential elements of the SDA are the qualifications and potential
of the candidate, an individualized, well thought-out career
development and research plan, a committed, capable preceptor, and
commitment on the part of the applicant institution to the development
of the candidate.  Documentation concerning each of these essential
elements must be included in the SDA application.

The candidate must be a citizen or noncitizen national of the United
States, or must have been lawfully admitted to the United States for
permanent residence and must possess an Alien Registration Receipt Card
(Form I-151 or I-551) at the time of an award.  The candidate must have
had the equivalent of at least two years of postdoctoral research
training or experience by the time the award is made.

Period of Support:  The SDA is limited to a single period of five
years.  Experienced investigators switching fields may request support
for a period of one to five years.

Salary Support:  The salary proposed must be consistent with the
established salary structure for full-time, 12-month appointments at
the grantee institution.  The funding component contribution to salary
support is geared to the institution's base as follows:  up to $45,000
- 100 percent of institutional base; $45,001 to $60,000 - $45,000;
$60,001 and over - 75 percent of institutional base, up to $75,000.
The grantee institution may supplement the funding component
contribution up to a level consistent with the institution's salary
scale.  Fringe benefits are paid out of grant funds in the same
proportion as the salary contribution.

Allowance for Support Costs:  In addition to salary support, funds up
to $50,000 in the aggregate may be requested for each year to support
research and/or career development activities.  Applicants may request
up to eight percent of direct costs for indirect costs.

RESEARCH OBJECTIVES

The NIAAA, NIDA, and NIMH provide an integrated Scientist Development
Award Program that is made up of three types of awards: the Scientist
Development Awards (K20, K21), the Research Scientist Development Award
(K02), and the Research Scientist Award (K05).  Together they provide
a continuum of support for scientists at several stages of their
careers.  The SDA is designed for beginning individuals showing great
promise as researchers but requiring further supervised research
experience to become outstanding independent investigators.  It may
also be utilized by established investigators seeking to make
significant changes in their research fields.

The SDA candidate must address a program of research relevant to the
mission of the funding component.  The trajectory of the candidate's
development as a research scientist is of paramount importance in this
program, and the intent is to assist a person with great potential to
become an outstanding scientist, fully able to function as an
independent investigator.  An individual who holds a SDA grant is
expected to apply for a small grant award, a First Independent Research
Support and Transition (FIRST) award, a traditional research grant, or
any other appropriate grant, providing that eligibility criteria for
the other award(s) and terms and conditions of the SDA are met.

SPECIAL REQUIREMENTS

Individuals must devote full-time (at least 80 percent) to career
development activities, supervised research, developing skill in
research methods, or other research-related activities relevant to
their career goals.  Providing health care is acceptable only when it
is necessary to maintain and enhance skills required for the conduct of
research.  Remuneration for clinical practice, consultation, or work
related to the awardee's research program must be assigned to the
grantee Institution and may not be retained by the awardee.

Use of PHS Research or Training Grant Funds Freed By An SDA

Funds budgeted in Institute-supported research or training grants for
the salaries or fringe benefits of individuals, but freed as a result
of an SDA award, may not be rebudgeted.  Questions regarding leaves of
absence, change of Institution, or transfer of award should be
addressed to the appropriate staff of the funding component.

Concurrent Application

The candidate for an SDA may not concurrently apply for any other PHS
grant, nor may there be another application pending funding.

STUDY POPULATIONS

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDY POPULATIONS

Applications for SDAs that involve human subjects are required to
include minorities and both genders in study populations.  This policy
applies to all research involving human subjects and human materials,
and applies to males and females of all ages.

APPLICATION PROCEDURES

Prospective applicants must contact the relevant office (see INQUIRIES)
for a copy of the complete PA and for information regarding
preapplication consultation and the application process.  The research
grant application kit form PHS 398 (rev. 9/91), is to be used in
applying for the SDA.  These forms are available from institutional
offices of sponsored research and from the offices listed under
INQUIRIES.

Special instructions prepared for the SDA are included in the complete
PA.  The title and number of this PA, Scientist Development Award
(PA-92-99), must be typed in Item 2a on the face page of the
application form.  Applications will be accepted on February 1, June 1,
and October 1.  Applications received after these receipt dates are
subject to assignment to the next cycle or may be returned to the
applicant if so requested by the applicant.

An original and five copies of the completed and signed application
must be submitted to:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892**

REVIEW CONSIDERATIONS

Review procedures of SDA applications will be the customary system of
dual review:  evaluation for scientific and technical merit by an
initial review group of the appropriate funding component consisting
primarily of nongovernment scientific experts, followed by evaluation
for policy and program relevance by the appropriate National Advisory
Council.  Only applications recommended for approval by the Council
will be considered for funding.  Applications will be reviewed for the
candidate's potential to develop into a productive alcohol, drug abuse,
and/or mental health researcher.  Reviewers will consider:  (1) the
qualifications of the candidate including the suitability of the
candidate relative to the eligibility criteria and purposes of the SDA;
(2) the soundness of the proposed career development plan; (3) the
preceptor and institutional environment, including the institution's
commitment to the candidate's career; (4) the nature and
scientific/technical merit of the research plan; and (5) the
appropriateness of the budget.  Detailed review criteria are listed in
the full PA.

AWARD CRITERIA

The responsibility for award decision resides solely with authorized
program staff of the funding component.  The following criteria will be
used in making award decisions:  (1) overall merit of the proposal; (2)
relevance of the proposal to the research priorities of the awarding
Institute and program balance; and (3) availability of funds.

INQUIRIES

The full PA, which includes the Special Instructions for preparing an
SDA application, up-to-date policy guidelines, and the application
forms may be obtained from any of the following offices:

National Institute on Alcohol Abuse and Alcoholism
OSAP National Clearinghouse for Alcohol and Drug Information
P.O. Box 2345
Rockville, MD  20847-2345
Telephone: (301) 468-2600 or 1-(800)-729-6686

National Institute on Drug Abuse
Grants Management Branch
5600 Fishers Lane, Room 8A-54
Rockville, MD  20857
Telephone:  (301) 443-6710

National Institute of Mental Health
Grants Awards and Operations Section
Grants Management Branch
5600 Fishers Lane, Room 7C-05
Rockville, MD  20857
Telephone:  (301) 443-4414

Inquiries regarding grants management may be directed to the NIMH
address given immediately above.

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.271, 93.277, 93.281.  Awards will be made under the authority of
Section 301 of the Public Health Service Act, as amended (42 U.S.C.
241) and administered in accordance with the PHS grants policy
statement revised October 1990.  This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or
health Systems Agency review.

$$P4 END ************************************************************

$$P5 BEGIN PA-92-100 ************************************************

INTEGRATED ADVANCED INFORMATION MANAGEMENT SYSTEMS

NIH GUIDE, Volume 21, Number 29, August 14, 1992

PA NUMBER:  PA-92-100

P.T. 34; K.W. 1004017

National Library of Medicine

PURPOSE

The National Library of Medicine (NLM) wishes to provide planning and
implementation grants to health science institutions that seek
assistance in integrating their existing scattered databases and
information systems into a comprehensive networked institutional
information management system capable of serving clinical, research,
educational, and administrative needs.

The Integrated Advanced Information Management Systems (IAIMS) program
described in this Program Announcement (PA) is a substantially revised
version of the NLMs existing IAIMS program, first announced in 1982.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Integrated Advanced Information Management Systems, is related to the
priority area of surveillance and data systems.  Potential applicants
may obtain a copy of "Healthy People 2000" (Full Report: Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1) through
the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applicants may be hospitals and medical centers, academic health
science centers, and other appropriate health science organizations.
Institutions that have received funding for Phase III "old" IAIMS
projects may apply for other grant programs of the NLM, but are not
eligible for "new" IAIMS support.  All others, including those that
have applied for IAIMS funding in the past, may apply to the revised
program.

MECHANISM OF SUPPORT

The mechanism of support for this PA is the medical library resource
grant (G08).  This grant mechanism only funds direct costs.

PROGRAM OBJECTIVES

Background

In 1983 the NLM initiated an award program to provide "assistance to
medical centers and health science institutions for planning and
development projects leading to the implementation of Integrated
Academic Information Management Systems (IAIMS)."  The program
announcement went on to say, "IAIMS are institution-wide computer
networks that link and relate library systems with individual and
institutional databases and information files, within and external to
the institution, for patient care, research, education, and
administration.  The goal is to create an organizational mechanism
within health institutions to more effectively manage the knowledge of
medicine, and to provide for a system of comprehensive information
access."

During the next decade over seventy institutions applied for IAIMS
grants in one or another of the 3 defined phases, and through FY 1991
26 awards had been made to 16 institutions.  The importance of
information management today is as great as ever, but the program
elements as originally defined by NLM deserve re-evaluation.  Lessons
have been learned from a decade of experience; furthermore, the climate
has changed significantly as a number of institutions made extensive
investments in information systems in recent years; most importantly,
the advent of the High Performance Computing and Communications
Initiative (HPCC) has dramatically enriched the possibilities of
information transfer, while increasing the complexity of information
management.

The NLM is the lead biomedical organization in the federal Government's
HPCC initiative.  The HPCC program recognizes "that unprecedented
computational power and its creative use are needed to investigate and
understand a wide range of scientific and engineering `grand challenge'
problems."  (1) Some of the problems identified are of obvious interest
to biomedicine:  National Research and Education Network (NREN),
biotechnology, transmission of digital images, intelligent gateways to
retrieve information from several life sciences databases, and
innovations in educational techniques, among others.

Accordingly, NLM is revising its IAIMS program with:

o  A name change:  replacing "academic" with "advanced" recognizes the
wide applicability of the IAIMS concept and the need to incorporate new
technology
o  Fusion of the old phases II and III (model and implementation) into
one operational phase
o  Changes in the level of support
o  Some modification of the scope and conditions of the grant
o  Incorporation of HPCC into the NLM vision of an integrated
information management system.

The Integrated Advanced Information Management Systems (IAIMS) Program

The revised IAIMS program has two phases:  A planning phase, and an
operational phase.

1.  IAIMS Planning Phase

"New" IAIMS planning phase resembles Phase I of the "old" IAIMS.
Various models can be used in information systems planning, but all
applications should include some form of self-study and allow for
certain key elements:

o  A description of the institution's information management resources,
current and five-year projection;
o  Development of an institutional information policy that addresses
both short-term and long-term goals;
o  Identification of leadership for planning;
o  Broad involvement of clinical and basic science faculty,
administration, and students;
o  Specification of desired strategic outcomes;
o  An outline of the planning process, including goals and timetables;
and
o  A comprehensive view that considers information needs of patient
care, research, education, and administration.

The outcome of planning activities is the development of an
institutional Information Management Plan, which should include
information resources management policies, an analysis of functions and
responsibilities of major information database managers, and a
description of how IAIMS will be developed, organized, and managed.

A total separation between planning and operations is not mandated;
institutions vary widely in the information system already in place at
the time of application.  An institution may, if it wishes, use or
introduce some operational elements during this planning period (for
example, an E-mail system.)

The IAIMS planning grant may be for up to $150,000 per year for one to
two years.  The grant supports direct costs only; funds are not
provided for indirect or overhead costs.

2.  IAIMS Operational Phase

Health science institutions that complete the IAIMS planning phase
successfully (or can demonstrate a comparably sophisticated information
management plan based on their own planning efforts) may apply to NLM
for an IAIMS operational phase grant to assist them in implementing the
plan.  Plans will vary for different institutions, but certain key
elements are of interest to all:

A.  Essential

o  A plan for developing the institution's information management
resources, and the requisite networks;
o  A functional Information Management Policy;
o  Designation of leadership with appropriate background and status;
o  A plan for supporting IAIMS after termination of the grant;
o  Timetables for reaching key features of the operational plan;
o  Reasonable timetables for major plan features such as development of
the network, organization of the management structure, appointment of
the leadership, and post-grant financing plans.  The ability of funded
institutions to reach such milestones in a timely manner will be
evaluated by the NLM when deciding annually on continuance of funding;

o  The ability to provide efficiently bibliographic and related
literature pertinent to health care delivery and research.  Significant
participation by the health sciences library is essential; and

o  Substantial incorporation of one or more elements of HPCC/NREN into
the institution's information system.  Connection to Internet, for
example, is one such element; other examples include collaboration
through high speed networks, distance learning, addressing of
computationally intensive problems in molecular biology in a
distributed environment, visualization techniques, and network-based
digital imaging.

B.  Highly Recommended

o  A clear relationship to clinical aspects of the health sciences,
such as linkage with a computerized patient record, a hospital
information system, clinical alert information/distribution systems,
clinically relevant expert systems, and/or systems for monitoring
quality of care and cost-control; and

o  Incorporation of current NLM objectives such as, connection to
national networks, direct access to Medline and/or extensive use of
Grateful Med, outreach components which improve information access for
health care workers in underserved rural or inner city locations, and
in other health care sites affiliated with the applicant.

C.  Optional

o  An apprenticeship in IAIMS may be incorporated into the operational
plan at the discretion of the applicant, through a position entitled
IAIMS Assistant.  An educational program should be described, outlining
the credentials of the candidates, the goals and duration of the
apprenticeship, the structure of the learning experience, and other
relevant material.  Personnel, travel and supply costs may be requested
up to a total of $50,000 for each year of the operational phase.  Costs
for apprentices should be budgeted in accordance with standard
institutional policy.

Other Information About the Operational Grant

The operational phase grant application may include an initial period
of model development at the discretion of the institution, but a
distinct interim period of model-building is not required.

Operational phase grants may be for up to $500,000 per year for five
years, or for up to $550,000 per year for five years if support for the
apprenticeship program is included.  Only direct costs are supported.

NLM support for IAIMS at an institution will terminate at the end of
the five-year operational phase, and is not renewable.

The word "institution" as used in this program description implies that
IAIMS will involve all major organizational components of the
institution to the extent feasible.  The NLM realizes that large
differences among medical centers are inevitable, and that at some
sites, certain suborganizations may not be suitable for incorporation
into the initial IAIMS plan.  However, a plan that is restricted to a
relatively small fraction of the institution has misunderstood the
point of the program, and will not be favorably reviewed.

APPLICATION PROCEDURES

Applicants are to use the PHS 398 (rev.9/91) application form, that
includes forms, instructions and additional information, available at
most academic medical centers,  the Extramural Programs office, NLM, at
the address listed under INQUIRIES, and from the Office of Grants
Inquiries, Division of Research Grants, National Institutes of Health,
Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/
496-7441.  Applications must be received by the standard NIH deadlines,
October 1, February 1, and June 1.  Late submissions will be held over
for the subsequent review cycle.  The title and number of this
announcement must be typed in item 2a on the face page of the
application.

The completed original application and five legible copies must be sent
or delivered to:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 2450
Bethesda, MD  20892**

REVIEW PROCEDURES

Applications will be assigned on the basis of established PHS referral
guidelines.  Applications will be reviewed for scientific and technical
merit by the NLM Biomedical Library Review Committee, in accordance
with the standard NIH peer review procedures.  Following
scientific-technical review, the application will receive a
second-level review by the NLM Board of Regents.

Critical Review Elements

For Planning Phase:

o  Responsiveness to the program description and guidelines;
o  Institutional environment;
o  Extent of involvement by key leadership; and
o  Short and long-term goals.

For Operational Phase:

o  Responsiveness to the program description and guidelines;
o  Institutional commitment to the IAIMS concept, including evidence of
significant cost-sharing;
o  Plans for support of IAIMS after the granting period; and
o  Sophistication and feasibility of the operational plan.

AWARD CRITERIA

Applications will compete for available funding with all other
applications assigned to the NLM.  The following will be considered in
making funding decisions:

o  Quality of the proposed project as determined by peer review;
o  Availability of funds; and
o  Program balance considerations.

INQUIRIES

Written and telephone inquiries are encouraged.  The opportunity to
clarify any issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Mr. Richard T. West
Extramural Programs
National Library of Medicine
Bethesda, MD  20894
Telephone:  (301) 496-3113
FAX:  (301) 402-0421

Direct inquiries regarding fiscal matters to:

Ms. Ellen G. Meltzer
Extramural Programs
National Library of Medicine
Bethesda, MD  20894
Telephone:  (301) 496-4253
FAX:  (301) 402-0421

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No. 93.879.  Awards are made under authorization of the PHS Act, Title
III, Part A, Section 301, Title IV, Part D, Subpart 2, Sections
472-476, as amended, Public Law 100-607.  This program is not subject
to the intergovernmental review requirements of Executive Order 12372
or Health Systems Agency review.

REFERENCE

(1) Grand Challenges 1993:  High Performance Computing and
Communications

To obtain a copy of this report, which was prepared for the President's
Office of Science and Technology Policy, call the IAIMS Program Officer
(see above) or send request to:  Federal Coordinating Council for
Science, Engineering, and Technology Committee on Physical,
Mathematical, and Engineering Sciences c/o National Science Foundation
Computer and Information Science and Engineering Directorate 1800 G
St., NW, Washington, DC 20550.

$$P5 END ************************************************************

                               ERRATA

$$E1 BEGIN R7 19920731 APPEND RFA CA/ES-92-23 BOTH *********************

BIOTECHNOLOGY TRANSFER TO EPIDEMIOLOGIC STUDIES IN CANCER

NIH GUIDE, Volume 21, Number 29, August 14, 1992

RFA:  CA/ES-92-23

P.T. 34; K.W. 0715035, 0760003, 785055, 0411005

National Cancer Institute
National Institute of Environmental Health Sciences

Letter of Intent Receipt Date:  October 22, 1992
Application Receipt Date:  November 19, 1992

This erratum is to correct the section MECHANISM OF SUPPORT in the
Request for Applications (RFA) that was distributed via the E-Guide,
Vol. 21, No. 27, July 31, 1992.  The following is the corrected section
in its entirety:

MECHANISM OF SUPPORT

This program will be supported by traditional research project (R01)
grants and Interactive Research Project Grants (IRPG).  Awards will be
administered under PHS grants policy as stated in the PHS Grants Policy
Statement, DHHS Publication No. (OASH) 90-50,000, revised October 1,
1990.

This RFA is a one-time solicitation.  The total project period for
applications submitted in response to the present RFA may not exceed
three years.  responsibility for the planning, direction, and execution
of the proposed project will be solely that of the applicant.
Competitive continuation applications will compete with all other
unsolicited applications and be reviewed by standing Division of
Research Grants study sections.  If the NCI and NIEHS determine that
there is a sufficient continuing program need, a request for renewal
applications may be announced.

$$E1 END ************************************************************

$$E2 BEGIN R8 19920731 APPEND RFA CA-92-91 BOTH ************************

TRANSFER OF NEW BIOSTATISTIC METHODS TO CANCER EPIDEMIOLOGY

NIH GUIDE, Volume 21, Number 29, August 14, 1992

RFA:  CA-92-21

P.T. 34; K.W. 0715035, 0785055, 1010013

National Cancer Institute

Letter of Intent Receipt Date:  September 30, 1992
Application Receipt Date:  November 12, 1992

This erratum is to correct the following sections of the Request for
Applications (RFA) that was distributed via the E-Guide, Vol. 21, No.
27, July 31, 1992.  The corrected sections are as follows:

MECHANISM OF SUPPORT

This program will be supported through National Institutes of Health
(NIH) traditional research project grants (R01).  responsibility for
the planning, direction, and execution of the proposed research will be
solely that of the applicant.  Awards will be administered under PHS
grants policy as stated in the PHS Grants Policy Statement, DHHS
Publication No. (OASH) 82-50,000 revised October 1, 1990.

The RFA is a one-time solicitation.  The total project period for
applications submitted in response to the present RFA may not exceed
three years.  Competitive continuation applications will compete with
all other unsolicited applications and be reviewed by Division of
Research Grants (DRG) study sections.  If the NCI determines that there
is a sufficient continuing program need,the NCI may announce a request
for renewal applications.

RESEARCH OBJECTIVES

Background

A decade or two ago, a biometry textbook, a medical statistics book,
and an understanding of the basic principles of statistics provided
applied biostatisticians with sufficient experimental designs and
methodologic techniques to analyze most problems encountered in cancer
research.  Meanwhile, theoretical statisticians explored statistical
problems of general interest without focussing on specific
applications.  Advances in biotechnology and high-speed computing tools
have driven the development of specialties and even subspecialties in
biostatistics.  Advances have been made in methods for analyzing cancer
survival data, understanding data with missing elements, allowing for
errors in variables, fitting random effects models, and utilizing the
bootstrap and other computationally intensive technologies.  Most of
this material is available only in technical journals and specialized
textbooks on theoretical statistics

REVIEW CONSIDERATIONS

The first bullet under the review criteria should read:

o  extent to which application addresses research objectives of the
RFA;

AWARD CRITERIA

The earliest anticipated date of award is July 1, 1993.

$$E2 END ************************************************************