From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mRNA for AML1 gene.
Date: 29 Jul 92 10:02:19 GMT
Distribution: bionet
Checksum: 59840     5

LOCUS       HUMAML1      1912 bp ss-mRNA            PRI       29-JUL-1992
DEFINITION  Human mRNA for AML1 gene.
ACCESSION   D10570 D90525
KEYWORDS    ATP/GTP binding.
SOURCE      Homo sapiens (library: human bone-marrow cDNA 5'-SRETCH (clontech)
            and human peripheral blood leukocyte cDNA 5'-STRETCH (Clontech))
            cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Miyoshi,H., Shimizu,K., Kozu,T., Maseki,M., Kaneko,Y. and Ohki,M.
  TITLE     The t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia
            clustered within a limited region of a novel gene, AML1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (1992) In press
  STANDARD  full staff_review
COMMENT     Data kindly submitted in computer readable form by:
            Hiroyuki Miyoshi
            Department of Immunology and Virology
            Saitama Cancer Center Research Institute
            818 Komuro Ina
            Saitama 362
            Japan
            Phone:  048-722-1111
            Fax:    048-722-1739
            The AML1 gene is rearranged by chromosomal translocation t(8;21) in
            acute myeloid leukemia.
FEATURES             Location/Qualifiers
     CDS             769..1521
                     /product="ORF"
                     /gene="AML1"
                     /codon_start=1
                     /translation="MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKL
                     RSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTL
                     VTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVA
                     TYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAP
                     TPNPRASLNHSTAFNPQPQSQMQEEDTAPWRC"
     polyA_signal    1880..1885
BASE COUNT      487 a    519 c    439 g    467 t
ORIGIN      Chromosome 21q22.3.
        1 attgagagaa cagagaacat gacaagtact tctagctcag cactgctcca actactgaag
       61 ctgattttca aggctactta aaaaaatctg cagcgtacat taatggattt ctgttgtgtt
      121 taaattctcc acagattgta ttgtaaatat tttatgaagt agagcatatg tatatattta
      181 tatatacgtg cacatacatt agtagcacta cctttggaag tctcagctct tgcttttcgg
      241 gactgaagcc agttttgcat gataaaagtg gccttgttac gggagataat tgtgttctgt
      301 tgggacttta gacaaaactc acctgcaaaa aactgacagg cattaactac tggaacttcc
      361 aaataatgtg tttgctgatc gttttactct tcgcataaat attttaggaa gtgtatgaga
      421 attttgcctt caggaacttt tctaacagcc aaagacagaa cttaacctct gcaagcaaga
      481 ttcgtggaag atagtctcca ctttttaatg cactaagcaa tcggttgcta ggagcccatc
      541 ctgggtcaga ggccgatccg cagaaccaga acgttttccc ctcctggact gttagtaact
      601 tagtctccct cctcccctaa ccacccccgc ccccccccac cccccgcagt aataaaggcc
      661 cctgaacgtg tatgttggtc tcccgggagc tgcttgctga agatccgcgc ccctgtcgcc
      721 gtctggtagg agctgtttgc agggtcctaa ctcaatcggc ttgttgtgat gcgtatcccc
      781 gtagatgcca gcacgagccg ccgcttcacg ccgccttcca ccgcgctgag cccaggcaag
      841 atgagcgagg cgttgccgct gggcgccccg gacgccggcg ctgccctggc cggcaagctg
      901 aggagcggcg accgcagcat ggtggaggtg ctggccgacc acccgggcga gctggtgcgc
      961 accgacagcc ccaacttcct ctgctccgtg ctgcctacgc actggcgctg caacaagacc
     1021 ctgcccatcg ctttcaaggt ggtggcccta ggggatgttc cagatggcac tctggtcact
     1081 gtgatggctg gcaatgatga aaactactcg gctgagctga gaaatgctac cgcagccatg
     1141 aagaaccagg ttgcaagatt taatgacctc aggtttgtcg gtcgaagtgg aagagggaaa
     1201 agcttcactc tgaccatcac tgtcttcaca aacccaccgc aagtcgccac ctaccacaga
     1261 gccatcaaaa tcacagtgga tgggccccga gaacctcgaa gacatcggca gaaactagat
     1321 gatcagacca agcccgggag cttgtccttt tccgagcggc tcagtgaact ggagcagctg
     1381 cggcgcacag ccatgagggt cagcccacac cacccagccc ccacgcccaa ccctcgtgcc
     1441 tccctgaacc actccactgc ctttaaccct cagcctcaga gtcagatgca ggaggaagac
     1501 acagcaccct ggagatgtta aggcagaagt cagttcttct gtccatccct ctccccagcc
     1561 aggatagagc tatcttttcc atctcatcct cagaagagac tcagaagaaa gatgacagcc
     1621 ctcagaatgc acgttatgag gaaggcagaa tgtgggtctg taattcctcc gtgtcccttc
     1681 tccccctctg caaaccgtcg taacaataat agttcctaac acatgggaca attgtgagga
     1741 ttaaatgagt tagcctgcag aaatcacttg atgcacagca catgggaagc attgtgtgta
     1801 tttattaatc cttcacaaag tctttgagat atatttttat caaatattta gcatggatcc
     1861 cggtacactt tcaatactta ataaatggtc aatgttattc tttttcacta tt
//