From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human transactivator protein (CREB) mRNA, complete cds.
Date: 29 Dec 92 20:55:36 GMT
Distribution: bionet
Checksum: 03146 6

LOCUS       HUMCREB      2454 bp ss-mRNA            PRI       11-DEC-1992
DEFINITION  Human transactivator protein (CREB) mRNA, complete cds.
ACCESSION   M27691
KEYWORDS    trans-activator protein.
SOURCE      Human placenta, cDNA to mRNA, clone hpG1CREBZ.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Hoeffler,J.P., Meyer,S., Yun,Y., Jameson,J.L. and Habener,J.F.
  TITLE     Cyclic AMP-responsive DNA-binding protein: Structure based on a
            cloned placental cDNA
  JOURNAL   Science 242, 1430-1433 (1988)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Hoeffler,J.P., Lee,C.Q., Meyer,S., Waeber,G. and Habener,J.F.
  TITLE     Cyclic AMP-stimulated gene transcription by the cellular expression
            of cDNA-encoded transactivator protein CREB
  JOURNAL   Unpublished (1989) Mol Endocrinology, Mass. Gen. Hosp., Boston MA
  STANDARD  full automatic
REFERENCE   3  (sites)
  AUTHORS   Meyer,T.E. and Habener,J.F.
  TITLE     Cyclic AMP response element binding protein CREB and modulator
            protein CREM are products of distinct genes
  JOURNAL   Nucleic Acids Res. 20, 6106-6106 (1992)
  STANDARD  full automatic
COMMENT     [1]  sites; amino acid sequence.
               Draft entry and computer-readable sequence for [1] kindly
            submitted by T.E.Meyer, 07-SEP-1989.
FEATURES             Location/Qualifiers
     CDS             117..1100
                     /note="transactivator protein"
                     /codon_start=1
                     /translation="MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAA
                     HATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVD
                     SVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPI
                     YQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ
                     ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRL
                     MKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD"
BASE COUNT      801 a    473 c    485 g    695 t
ORIGIN      
        1 cgcggcggag gtgtagtttg acgcggtgtg ttacgtgggg gagagaataa aactccagcg
       61 agatccgggc cgtgaacgaa agcagtgacg gaggagcttg taccaccggt aactaaatga
      121 ccatggaatc tggagccgag aaccagcaga gtggagatgc agctgtaaca gaagctgaaa
      181 accaacaaat gacagttcaa gcccagccac agattgccac attagcccag gtatctatgc
      241 cagcagctca tgcaacatca tctgctccca ccgtaactct agtacagctg cccaatgggc
      301 agacagttca agtccatgga gtcattcagg cggcccagcc atcagttatt cagtctccac
      361 aagtccaaac agttcagatt tcaactattg cagaaagtga agattcacag gagtcagtgg
      421 atagtgtaac tgattcccaa aagcgaaggg aaattctttc aaggaggcct tcctacagga
      481 aaattttgaa tgacttatct tctgatgcac caggagtgcc aaggattgaa gaagagaagt
      541 ctgaagagga gacttcagca cctgccatca ccactgtaac ggtgccaact ccaatttacc
      601 aaactagcag tggacagtat attgccatta cccagggagg agcaatacag ctggctaaca
      661 atggtaccga tggggtacag ggcctgcaaa cattaaccat gaccaatgca gcagccactc
      721 agccgggtac taccattcta cagtatgcac agaccactga tggacagcag atcttagtgc
      781 ccagcaacca agttgttgtt caagctgcct ctggagacgt acaaacatac cagattcgca
      841 cagcacccac tagcactatt gcccctggag ttgttatggc atcctcccca gcacttccta
      901 cacagcctgc tgaagaagca gcacgaaaga gagaggtccg tctaatgaag aacagggaag
      961 cagctcgaga gtgtcgtaga aagaagaaag aatatgtgaa atgtttagaa aacagagtgg
     1021 cagtgcttga aaatcaaaac aagacattga ttgaggagct aaaagcactt aaggaccttt
     1081 actgccacaa atcagattaa tttgggattt aaattttcac ctgttaaggt ggaaaatgga
     1141 ctggcttggc cacaacctga aagacaaaat aaacatttta ttttctaaac atttcttttt
     1201 ttctatgcgc aaaactgcct gaaagcaact acagaatttc attcatttgt gcttttgcat
     1261 taaactgtga atgttccaac acctgcctcc acttctcccc tcaagaaatt ttcaacgcca
     1321 ggaatcatga agagacttct gcttttcaac ccccaccctc ctcaagaagt aataatttgt
     1381 ttacttgtaa attgatggga gaaatgagga aaagaaaatc tttttaaaaa tgatttcaag
     1441 gtttgtgctg agctccttga ttgccttagg gacagaatta ccccagcctc ttgagctgaa
     1501 gtaatgtgtg ggccgcatgc ataaagtaag taaggtgcaa tgaagaagtg ttgattgcca
     1561 aattgacatg ttgtcacatt ctcattgtga attatgtaaa gttgttaaga gacataccct
     1621 ctaaaaaaga actttagcat ggtattgaag gaattagaaa tgaatttgga gtgcttttta
     1681 tgtatgttgt cttcttcaat actgaaaatt tgtccttggt tcttaaaagc attctgtact
     1741 aatacagctc ttccataggg cagttgttgc ttcttaattc agttctgtat gtgttcaaca
     1801 tttttgaata cattaaaaga agtaaccaac tgaacgacaa agcatggtat ttgaatttta
     1861 aattaaagca aagtaaataa aagtacaaag catattttag ttagtactaa attcttagta
     1921 aaatgctgat cagtaaacca atcccttgag ttatataaca agatttttaa ataaatgtta
     1981 ttgtcctcac cttcaaaaat atttatattg tcactcattt acgtaaaaag atatttctaa
     2041 tttactgttg cccattgcac ttacatacca ccaccaagaa agccttcaag atgtcaaata
     2101 aagcaaagtg atatatattt gtttatgaaa tgttacatgt agaaaaatac tgattttaaa
     2161 tattttccat attaacaatt taacagagaa tctctagtga attttttaaa tgaaagaagt
     2221 tgtaaggata taaaaagtac agtgttagat gtgcacaagg aaagttattt tcagacatat
     2281 ttgaatgact gctgtactgc aatatttgga ttgtcattct tacaaaacat ttttttgttc
     2341 tcttgtaaaa agagtagtta ttagttctgc tttagctttc caatatgctg tatagccttt
     2401 gtcattttat aattttaatt cctgattaaa acagtctgta tttgtgtata tcat
//