From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human pancreatic lipase (PNLIP) mRNA, complete cds.
Date: 4 Sep 92 10:04:23 GMT
Distribution: bionet
Checksum: 34488     4

LOCUS       HUMPNLIP     1454 bp ss-mRNA            PRI       04-SEP-1992
DEFINITION  Human pancreatic lipase (PNLIP) mRNA, complete cds.
ACCESSION   M93285
KEYWORDS    pancreatic lipase.
SOURCE      Homo sapiens pancreas cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Giller,T., Buchwald,P., Blum-Kaelin,D. and Hunziker,W.
  TITLE     Two novel human pancreatic lipase related proteins, hPLRP1 and
            hPLRP2: Differences in colipase dependence and in lipase activity
  JOURNAL   J. Biol. Chem. 267, 16509-16516 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     sig_peptide     1..48
                     /gene="PNLIP"
                     /codon_start=1
     CDS             1..1398
                     /note="precursor"
                     /product="lipase"
                     /gene="PNLIP"
                     /codon_start=1
                     /translation="MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHIL
                     PWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENW
                     LANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSP
                     SNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDV
                     IHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFA
                     ACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGK
                     TNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGT
                     LKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCS
                     PETVREEVLLTLTPC"
     mat_peptide     49..1395
                     /EC_number="3.1.1.3"
                     /product="lipase"
                     /gene="PNLIP"
                     /codon_start=1
     polyA_signal    1434..1439
                     /gene="PNLIP"
     polyA_site      1454
                     /gene="PNLIP"
BASE COUNT      415 a    313 c    349 g    377 t
ORIGIN
        1 atgctgccac tttggactct ttcactgctg ctgggagcag tagcaggaaa agaagtttgc
       61 tacgaaagac tcggctgctt cagtgatgac tccccatggt caggaattac ggaaagaccc
      121 ctccatatat tgccttggtc tccaaaagat gtcaacaccc gcttcctcct atatactaat
      181 gagaacccaa acaactttca agaagttgcc gcagattcat caagcatcag tggctccaat
      241 ttcaaaacaa atagaaaaac tcgctttatt attcatggat tcatagacaa gggagaagaa
      301 aactggctgg ccaatgtgtg caagaatctg ttcaaggtgg aaagtgtgaa ctgtatctgt
      361 gtggactgga aaggtggctc ccgaactgga tacacacaag cctcgcagaa catcaggatc
      421 gtgggagcag aagtggcata ttttgttgaa tttcttcagt cggcgttcgg ttactcacct
      481 tccaacgtgc atgtcattgg ccacagcctg ggtgcccacg ctgctgggga ggctggaagg
      541 agaaccaatg ggaccattgg acgcatcaca gggttggacc cagcagaacc ttgctttcag
      601 ggcacacctg aattagtccg attggacccc agcgatgcca aatttgtgga tgtaattcac
      661 acggatggtg cccccatagt ccccaatttg gggtttggaa tgagccaagt cgtgggccac
      721 ctagatttct ttccaaatgg aggagtggaa atgcctggat gtaaaaagaa cattctctct
      781 cagattgtgg acatagacgg aatctgggaa gggactcgag actttgcggc ctgtaatcac
      841 ttaagaagct acaaatatta cactgatagc atcgtcaacc ctgatggctt tgctggattc
      901 ccctgtgcct cttacaacgt cttcactgca aacaagtgtt tcccttgtcc aagtggaggc
      961 tgcccacaga tgggtcacta tgctgataga tatcctggga aaacaaatga tgtgggccag
     1021 aaattttatc tagacactgg tgatgccagt aattttgcac gttggaggta taaggtatct
     1081 gtcacactgt ctggaaaaaa ggttacagga cacatactag tttctttgtt cggaaataaa
     1141 ggaaactcta agcagtatga aattttcaag ggcactctca aaccagatag tactcattcc
     1201 aatgaatttg actcagatgt ggatgttggg gacttgcaga tggttaaatt tatttggtat
     1261 aacaatgtga tcaacccaac tttacctaga gtgggagcat ccaagattat agtggagaca
     1321 aatgttggaa aacagttcaa cttctgtagt ccagaaaccg tcagggagga agttctgctc
     1381 accctcacac cgtgttagga gactactgtt atttgaccaa tgaattgact tctaataaaa
     1441 tctagtggtg atgc
//