From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rattus norvegicus granulin mRNA, complete cds.
Date: 31 Jul 92 10:02:01 GMT
Distribution: bionet
Checksum: 57378     6

LOCUS       RATGABE12A   2113 bp ss-mRNA            ROD       31-JUL-1992
DEFINITION  Rattus norvegicus granulin mRNA, complete cds.
ACCESSION   M97750
KEYWORDS    epithelin; granulin.
SOURCE      Rattus norvegicus (strain Sprague-Dawley) (library: lambda-gt11)
            adult kidney cDNA to mRNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Bhandari,V., Giaid,A. and Bateman,A.
  JOURNAL   Unpublished (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     5'UTR           1..14
                     /gene="granulin"
     sig_peptide     15..65
                     /gene="granulin"
                     /codon_start=1
     CDS             15..1781
                     /function="putative growth factor precursor"
                     /note="The precursor contains the sequence of rat granulin
                     A(Bateman,A.et al. BBRC (1990),173,1161-1168) / epithelin
                     1and epithelin 2 (Shoyab,M.et al.(1990) PNAS 87,
                     7912-7916)."
                     /product="granulin"
                     /gene="granulin"
                     /evidence=EXPERIMENTAL
                     /codon_start=1
                     /translation="MWILVSWLALVARLVAGTQCPDGQFCPVACCLDQGGANYSCCNP
                     LLDTWPIITSRRLDGSCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRG
                     FHCSADGKSCSQISDSLLGAVQCPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDR
                     VHCCPHGASCDLVHTRCISPTGTHPLLKKFPAQRTNRAVASFSVVCPDAKTQCPDDST
                     CCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKDYTTDLMTKLPGYPV
                     NEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTCEL
                     GVLQVPWMKKVTASLSLPDPQILKNDVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAV
                     CCLDHQHCCPQGFKCMDEGYCQKGDRMVAGLEKMPVRQTTLLQHGDIGCDQHTSCPVG
                     QTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDAGSVQPSMDLTFG
                     SKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTK
                     CLRKKTPRWDILLRDPAPRPLL"
     mat_peptide     624..791
                     /function="growth factor"
                     /product="granulin B/epithelin 2"
                     /note="putative"
                     /codon_start=1
     mat_peptide     846..1013
                     /function="Growth factor"
                     /product="granulin A/epithelin 1"
                     /note="putative"
                     /codon_start=1
     3'UTR           1782..2113
                     /gene="granulin"
     polyA_site      2099..2104
                     /gene="granulin"
BASE COUNT      430 a    593 c    581 g    509 t
ORIGIN
        1 gcgcaggcaa gaccatgtgg atcctggtga gctggctggc cttagtggca aggctggtgg
       61 ctggaacaca gtgcccagat ggtcaattct gccctgttgc ctgctgcctt gaccagggag
      121 gagccaacta cagctgctgt aaccctcttc tggacacatg gcctataata acgagccgtc
      181 gtctagatgg ctcctgccag atccgtgacc actgtcctga tggctactct tgtcttctca
      241 ctgtgtctgg gacttccagc tgctgcccgt tctctgaggg tgtatcttgt gatgatggcc
      301 agcactgctg cccccggggc ttccactgta gtgcggatgg gaaatcctgc tctcagatat
      361 cagatagcct cttgggtgct gtccagtgtc ctggtagcca gttcgaatgt cctgactccg
      421 ccacctgctg tattatgatt gatggttcct gggggtgctg ccccatgccc caggcctctt
      481 gctgtgaaga cagagtgcat tgctgtcccc acggggcctc ctgtgacctg gttcacacgc
      541 gatgcatttc acccacgggc acccacccct tactaaagaa attccccgca caaaggacca
      601 acagggcagt ggcttccttt tccgtggtgt gccctgatgc taagacccag tgccctgatg
      661 actctacctg ctgtgagcta cccactggga agtatggctg ttgtccaatg cccaacgcca
      721 tctgctgttc cgaccacctg cactgctgcc cccaggacac tgtatgtgac ctgatccaga
      781 gcaagtgcat atccaaggac tacaccacag atctcatgac caagctgcct ggatacccag
      841 tgaatgaggt gaagtgcgac ttggaggtga gctgtcctga tggctacacc tgctgccgcc
      901 tcaacactgg ggcctggggc tgctgtccat tcaccaaggc tgtgtgttgt gaagaccaca
      961 ttcactgctg cccagccggg tttcagtgtc acacagagac aggaacctgt gaactgggag
     1021 tccttcaggt accctggatg aaaaaggtca cggcctccct cagcctgcca gacccacaga
     1081 tcttgaagaa tgatgtcccc tgtgatgact tcagtagctg tccttctaac aatacctgct
     1141 gcagactcag ttctggggac tggggctgct gtcccatgcc agaggctgtc tgctgcttag
     1201 accaccagca ttgctgccct cagggtttca aatgtatgga tgaggggtac tgtcagaagg
     1261 gagacagaat ggtggctggc ctggagaaga tgcctgtccg ccagacaact ctgctccaac
     1321 atggagatat tggttgtgac cagcatacca gctgcccagt agggcaaaca tgctgcccaa
     1381 gcctgaaggg aagttgggcc tgctgccagt tgccccatgc tgtgtgctgt gaggaccggc
     1441 agcactgttg cccggctggg tacacctgca acgtgaaggc gagaacctgt gagaaggatg
     1501 caggctctgt ccagccttcc atggacctga cctttggctc taaggttggg aatgtggaat
     1561 gtggtgccgg acatttctgc catgataacc agtcctgttg taaagacagc caaggaggct
     1621 gggcctgctg tccctatgta aagggtgtct gctgtagaga tggacgtcac tgttgtccca
     1681 ttggcttcca ctgttcagcc aagggaacca agtgtttgcg gaagaagacc cctcgctggg
     1741 acatactttt gagggatcca gccccaagac cgctactgtg aggaagggct aacgactaaa
     1801 gaactccaca gtcctgggaa ccctgttctg agggtatcca ccactcaggc ctccctggca
     1861 cctcttcctt tagtctcccc ggcctactca ttctgagtca ccccatcacc atggaaggtg
     1921 gggcctcaaa ctaagacctt ctcttatgga aagaaggctg tggcaaaagc cccgtatcaa
     1981 actgccattt cttatgattt ctgtggacct tgtggccagg tgctcttctc gatccacagg
     2041 tgttgtgtga gcttgctttt gtgtgtgtgt gtgtgcgcgc gtgcgagcgt gttgctccaa
     2101 taaagtttgt acc
//