From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human nerve growth factor receptor mRNA, complete cds.
Date: 5 Nov 92 23:11:43 GMT
Distribution: bionet
Checksum: 41644 7

LOCUS       HUMNGFR      3386 bp ss-mRNA            PRI       15-JUN-1989
DEFINITION  Human nerve growth factor receptor mRNA, complete cds.
ACCESSION   M14764
KEYWORDS    nerve growth factor receptor.
SOURCE      Human melanoma cell line A875, cDNA to mRNA, clone E1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Johnson,D.E., Lanahan,A.A., Buck,C.R., Sehgal,A., Morgan,C.,
            Mercer,E., Bothwell,M. and Chao,M.
  TITLE     Expression and structure of the human NGF receptor
  JOURNAL   Cell 47, 545-554 (1986)
  STANDARD  full automatic
COMMENT     Draft entry and clean copy sequence for [1] kindly provided by
            M.Bothwell, 28-APR-1987.
FEATURES             Location/Qualifiers
     mRNA            <1..3386
                     /gene="NGFR"
     sig_peptide     114..197
                     /gene="NGFR"
                     /codon_start=1
     mat_peptide     198..1394
                     /product="nerve growth factor receptor"
                     /gene="NGFR"
                     /codon_start=1
     variation       1105
                     /note="g sometimes t"
     CDS             114..1397
                     /product="nerve growth factor receptor"
                     /codon_start=1
                     /translation="MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECC
                     KACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEA
                     DDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANH
                     VDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAP
                     PEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWN
                     SCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGG
                     LYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWAT
                     QDSATLDALLAALRRIQRADLVESLCSESTATSPV"
BASE COUNT      656 a   1104 c   1030 g    596 t
ORIGIN      5 bp upstream of SacII site; 17q21-q22.
        1 gccgcggcca gctccggcgg gcaggggggg cgctggagcg cagcgcagcg cagccccatc
       61 agtccgcaaa gcggaccgag ctggaagtcg agcgctgccg cgggaggcgg gcgatggggg
      121 caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg cttctggggg
      181 tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac agcggtgagt
      241 gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc aaccagaccg
      301 tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg accgagccgt
      361 gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc gtggaggccg
      421 acgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact gggcgctgcg
      481 aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag gacaagcaga
      541 acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac cacgtggacc
      601 cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag tgcacacgct
      661 gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc acacccccag
      721 agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca gaacaagacc
      781 tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc cagcccgtgg
      841 tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg gctgctgtgg
      901 ttgtgggcct tgtggcctac atagccttca agaggtggaa cagctgcaag cagaacaagc
      961 aaggagccaa cagccggcca gtgaaccaga cgcccccacc agagggagaa aaactccaca
     1021 gcgacagtgg catctccgtg gacagccaga gcctgcatga ccagcagccc cacacgcaga
     1081 cagcctcggg ccaggccctc aagggtgacg gaggcctcta cagcagcctg cccccagcca
     1141 agcgggagga ggtggagaag cttctcaacg gctctgcggg ggacacctgg cggcacctgg
     1201 cgggcgagct gggctaccag cccgagcaca tagactcctt tacccatgag gcctgccccg
     1261 ttcgcgccct gcttgcaagc tgggccaccc aggacagcgc cacactggac gccctcctgg
     1321 ccgccctgcg ccgcatccag cgagccgacc tcgtggagag tctgtgcagt gagtccactg
     1381 ccacatcccc ggtgtgagcc caaccgggga gcccccgccc cgccccacat tccgacaacc
     1441 gatgctccag ccaacccctg tggagcccgc acccccaccc tttggggggg gcccgcctgg
     1501 cagaactgag ctcctctggg caggacctca gagtccaggc cccaaaacca cagccctgtc
     1561 agtgcagccc gtgtggcccc ttcacttctg accacacttc ctgtccagag agagaagtgc
     1621 ccctgctgcc tccccaaccc tgcccctgcc ccgtcaccat ctcaggccac ctgccccctt
     1681 ctcccacact gctaggtggg ccagcccctc ccaccacagc aggtgtcata tatggggggc
     1741 caacaccagg gatggtacta gggggaagtg acaaggcccc agagactcag agggaggaat
     1801 cgaggaacca gagccatgga ctctacactg tgaacttggg gaacaagggt ggcatcccag
     1861 tggcctcaac cctccctcag cccctcttgc cccccacccc agcctaagat gaagaggatc
     1921 ggaggcttgt cagagctggg aggggttttc gaagctcagc ccacccccct cattttggat
     1981 ataggtcagt gaggcccagg gagaggccat gattcgccca aagccagaca gcaacgggga
     2041 ggccaagtgc aggctggcac cgccttctct aaatgagggg cctcaggttt gcctgagggc
     2101 gaggggaggg tggcaggtga ccttctggga aatggcttga agccaagtca gctttgcctt
     2161 ccacgctgtc tccagacccc caccccttcc ccactgcctg cccacccgtg gagatgggat
     2221 gcttgcctag ggcctggtcc atgatggagt caggtttggg gttcgtggaa agggtgctgc
     2281 ttccctctgc ctgtccctct caggcatgcc tgtgtgacat cagtggcatg gctccagtct
     2341 gctgccctcc atcccgacat ggacccggag ctaacactgg cccctagaat cagcctaggg
     2401 gtcagggacc aaggacccct caccttgcaa cacacagaca cacgcacaca cacacacagg
     2461 aggagaaatc tcacttttct ccatgagttt tttctcttgg gctgagactg gatactgccc
     2521 ggggcagctg ccagagaagc atcggaggga attgaggtct gctcggccgt cttcactcgc
     2581 ccccgggttt ggcgggccaa ggactgccga ccgaggctgg agctggcgtc tgtcttcaag
     2641 ggcttacacg tggaggaatg ctcccccatc ctccccttcc ctgcaaacat ggggttggct
     2701 gggcccagaa ggttgcgatg aagaaaagcg ggccagtgtg ggaatgcggc aagaaggaat
     2761 tgacttcgac tgtgacctgt ggggatttct cccagctcta gacaaccctg caaaggactg
     2821 ttttttcctg agcttggcca gaagggggcc atgaggcctc agtggacttt ccaccccctc
     2881 cctggcctgt tctgttttgc ctgaagttgg agtgagtgtg gctcccctct atttagcatg
     2941 acaagcccca ggcaggctgt gcgctgacaa ccaccgctcc ccagcccagg gttcccccag
     3001 ccctgtggaa gggactagga gcactgtagt aaatggcaat tctttgacct caacctgtga
     3061 tgaggggagg aaactcacct gctggcccct cacctgggca cctggggagt gggacagagt
     3121 ctgggtgtat ttattttcct ccccagcagg tggggagggg gtttggtggc ttgcaagtat
     3181 gttttagcat gtgtttggtt ctggggcccc tttttactcc ccttgagctg agatggaacc
     3241 cttttggccc ccagctgggg gccatgagct ccagaccccc agcaaccctc ctatcacctc
     3301 ccctccttgc ctcctgtgta atcatttctt gggccctcct gaaacttaca cacaaaacgt
     3361 taagtgatga acattaaata gcaaag
//