HDTenEightyP/NetNews huggingface dataset:
From: dbd@theory.BCHS.UH.EDU (Dan Davison)
Newsgroups: bionet.announce
Subject: New Journal: Computational Biology: The Journal of Computational Cell Biology
Date: 22 Dec 92 21:50:07 GMT


Feel free to contact me or D. Kingsbury about this announcement.

dan davison
----------------------------------------------------------------------------

Announcing an important new quarterly peer-review journal.

March 1993

COMPUTATIONAL BIOLOGY

The Journal of Computational Molecular Cell Biology

Editors

Daniel B. Davison, Ph.D.   David T. Kingsbury, Ph.D. Thomas Marr, Ph.D.
University of Houston	   Johns Hopkins University  Cold Springs Harbor Labs
                           School of Medicine

Goals: First, to provide a forum for communication of scientific and 
technical issues  associated with the analysis, management, and 
visualization of cellular information at the molecular level.  
COMPUTATIONAL BIOLOGY will accept papers on: algorithms, 
genomics; mathematical modeling and simulation of biological 
processes; new methods for sequence analysis, including, for example, 
parallel methods; design and implementation of biological databases; 
biological expert system design and use; reasoning by analogy; 
hypothesis formation and testing by machine; and, information 
theory.

Second, is the communication of significant biological problems 
to investigators traditionally outside of biology, but otherwise 
in appropriate areas of science and technology.  This will be accomplished 
by soliciting mini-reviews in diverse areas, and by providing a forum 
for the informal exchange of theories and experimental approaches.

The growth of molecular cell biology has created large amounts of 
complex data, and challenges to data handling, data analysis, and 
interpretation.  The mounting volume and richness of data require 
quantitative and multidisciplinary approaches for analysis and 
interpretation.

For submission of manuscripts send three copies to: David T. Kingsbury, 
The Welch Laboratory, The Johns Hopkins University School of 
Medicine, 1830 East Monument, 3rd Floor, Baltimore, MD 21205-2100.  
Phone: (410) 995-9705. E-mail: dkingsbu@library.welch.jhu.edu.

Subscription rate:  Volume 1 quarterly 1993.
Publisher: Mary Ann Leibert, Inc.
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: Software used to access BIOSCI in 1991
Date: 31 Dec 92 23:02:52 GMT
Organization: BIOSCI International Newsgroups for Biology



In the Fall 1991 BIOSCI readership survey, 333 of the respondents
(55.8%) used newsreading software while 264 of the respondents read
the newsgroups via e-mail (44.2%).  The breakdown of the newsreaders
used was as follows:

105	rn
40	nn
25	xrn
24	unknown newsreader (respondent was unsure of program name)
23	VMS News
20	ANUNEWS
17	vnews
15	GNUS
12	Netnews
9	trn
5	Bulletin
5	Newswatcher
5	vn
4	NEWSRDR
4	NNTP clinet software
4	NeXT NewsGrazer
4	readnews
4	rrn
3	TheNews
3	VAXNotes
2	rnews
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: Software used to access BIOSCI in 1992
Date: 31 Dec 92 23:01:48 GMT
Organization: BIOSCI International Newsgroups for Biology



In the Fall 1992 BIOSCI readership survey, 506 of the respondents
(58.7%) used newsreading software while 356 of the respondents read
the newsgroups via e-mail (41.3%).  The breakdown of the newsreaders
used was as follows:

135	rn
67	nn
37	ANUNEWS
35	unknown newsreader (respondent was unsure of program name)
35	xrn
27	GNUS
26	trn
25	VMS News
15	Nuntius
14	vnews
13	Netnews
12	tin
10	Trumpet
8	Newswatcher
6	TheNews
5	rrn
4	NEWSRDR
4	WinQVTnet
4	readnews
4	vn
4	xvnews
3	rnews
3	tass
2	Gopher
2	NeXT NewsGrazer
2	VAXNotes
1	Bulletin
1	GNEWS
1	Internews
1	TinCan
From: kristoff@net.bio.net (David Kristofferson)
Newsgroups: bionet.announce
Subject: 1992 BIOSCI readership distribution
Date: 31 Dec 92 22:58:17 GMT
Organization: BIOSCI International Newsgroups for Biology


Geographical Distribution of Fall 1992 BIOSCI Survey Respondents 
----------------------------------------------------------------

Total Responses Received (after removing duplicates from same address) = 862

Estimated response rate 64%.  This is based on the fraction of
addresses on BIONEWS mailing list at net.bio.net that responded to
survey.

Estimated BIONEWS/bionet.general readership = approx. 1350.  This is
about a 47% increase from Fall 1991 (~920) to Fall 1992 (~1350).


Breakdown by Country
--------------------

No.	Country		  %
---	-------		 ---
474	USA		55.0%	(non-U.S. is 45.0%)
90	UK		10.4
47	Australia	 5.5
45	Canada		 5.2
37	Germany		 4.3
26	France		 3.0
17	Japan		 2.0
17	Netherlands	 2.0
11	Switzerland	 1.3
10	New Zealand	 1.2
9	Belgium		 1.0
8	Spain		 0.9
7	South Africa	 0.8
6	Israel		 0.7
6	Sweden		 0.7
5	Austria		 0.6
5	Finland		 0.6
5	Italy		 0.6
5	Taiwan		 0.6
4	Czechoslovakia	 0.5
4	Norway		 0.5
3	Denmark		 0.3
3	Turkey		 0.3
2	Estonia		 0.2
2	India		 0.2
2	Ireland		 0.2
2	Poland		 0.2
1	Brazil		 0.1
1	Costa Rica	 0.1
1	Ecuador		 0.1
1	Hong Kong	 0.1
1	Korea		 0.1
1	Mexico		 0.1
1	Philippines	 0.1
1	Portugal	 0.1
1	Singapore	 0.1
1	Uruguay		 0.1
0	Columbia	 0.0	(These countries had respondents
0	Egypt		 0.0     in the 1991 survey but not
0	Greece		 0.0     in 1992.)
From: Rob_Last@qmrelay.mail.cornell.edu (Rob Last)
Newsgroups: bionet.announce
Subject: NSF Postdoctoral Fellowship Program in Plant Biology
Date: 31 Dec 92 16:40:28 GMT

Dear Colleagues,

We are soliciting your comments concerning the NSF Postdoctoral
Fellowship Program in Plant Biology.  At a recent meeting on plant
biochemistry, several scientists emphasized the importance of these
fellowships for attracting new researchers into the plant sciences.
We wish to convey to NSF, and the rest of the scientific community,
the impact that this program has had on increasing the overall quality
of plant molecular biology by attracting high quality, productive
scientists from other areas into the field of plant biology.

We would appreciate receiving your comments on the NSF fellowship
program, both pro and con.  Please send your comments concerning this
program to Rob Last: by Fax: (607) 254-1242; Mail: Boyce Thompson
Institute, Cornell University, Tower Rd.. Ithaca, NY 14853-1801, or
Email: rob_last@qmrelay.mail.cornell.edu, before February 1, 1993.

We will then write a consensus letter reflecting the comments that we
receive about the NSF plant postdoctoral program for submission to one
of the American plant molecular biology journals.  Thank you for your
input on this important program.  Please distrubute this posting to
any interested colleagues.

Sincerely,

Gloria Coruzzi, New York University
Robert Last, Boyce Thompson Institute
From: minobe@rtcs0.riken.go.jp (Guest2 (Yuzo Minobe))
Newsgroups: bionet.announce
Subject: Rice Genome newsletter issue two available
Date: 22 Dec 92 03:00:36 GMT


  
RICE GENOME Newslette second issue published
22. Dec. 1992

The Rice Genome Research Program (RGP) of Japan has produced the
second issue of its newsletter Rice Genome. The newsletter aims to
inform all researchers interested in mapping and analyzing plant
genomes. The main objective is to enhance international cooperative
research efforts for rice genome analysis and for the isolation and
utilization of useful rice genes in plant breeding and biotechnology.

The second issue contents:

- Analysis of Rice Root cDNA Clones, listing identified protein
    sequences from root cDNA
- Polymorphism Analysis of Rice Genome by PCR, introducing the DPRAPD method
- A revised RFLP Linkage Map with 418 Informative Markers 
- Physical Mapping of Rice Genome
- Database system of RGP
- Advanced sequencing protocol
- Reports on:    - Chinese Rice Genome Research Program
                         - Plant Genome I meeting in San Diego last November
                         - Biotechnology Center in Punjab, India
                         - Human Genome Center in Japan. 

The list of available DNA clones has been extended and the application
form for clone requests is included.

The next issue of the newsletter will be published in early summer
1993. We welc ome news items and articles on rice genome mapping and
analysis from the interna tional research community.

The newsletter is available free of charge. To have your name added to
the mailing list, fill in the mailing list form and send it to the
address below. This issue is mailed to ca. 1500 people, including all
participants of the Plant Genome I meeting (San Diego, Nov. 9-11, 1992).

Dr. Ilkka Havukkala
Editorial Office of Rice Genome
Rice Genome Research Program (RGP)
National Institute of Agrobiological Resources
2-1-2, Kannondai
Tsukuba
Ibaraki 305
Japan
Fax: +81-298-38-7468
e-mail (Internet): minobe@rtcs0.riken.go.jp
From: aston@HAL.HAHNEMANN.EDU ("GARY ASTON-JONES, PH.D.")
Newsgroups: bionet.neuroscience
Subject: RE: Pain and Analgesia Part II
Date: 23 Dec 92 15:33:42 GMT
Distribution: bionet

As for NE and descending control of pain, I suggest you read papers by
Jones and Gebhart, in the mid to late 80s.  They find alpha2 receptor-
mediated spinal analgesia.  Good luck, and happy holidays.
Gary Aston-Jones
Newsgroups: bionet.neuroscience
From: erwin@trwacs.fp.trw.com (Harry Erwin)
Subject: Re: unconventional communication
Organization: TRW Systems Division, Fairfax VA
Distribution: bionet
Date: Wed, 30 Dec 1992 22:57:37 GMT

Yao and Freeman, 1990. "Model of Biological Pattern Recognition with
Spatially Chaotic Dynamics." Neural Networks. Vol 3, Nr 2, 153-170.

Although Pribram would like field potentials to affect neural processing,
Freeman appears to be closer to the orthodox position. Werbos suggests
that field-like things happen in the brain, but primarily because the same
equations apply. I came to much the same position when I examined
holographic models of the brain. My term was "pseudo-holography."

Cheers,
-- 
Harry Erwin
Internet: erwin@trwacs.fp.trw.com
From: GWU5042@GWUVM.GWU.EDU (Hans Xie)
Newsgroups: bionet.neuroscience
Subject: unconventional communication
Date: 26 Dec 92 20:06:46 GMT
Distribution: bionet

I am interested in the neuron-neuron communication, or more generally,
cell-cell communication.  Neurons can communication through hormones,
neurotransmitters, or cell adhesion molecules, or possibly through
gap junction.  Is it possible that neurons communicate via certain
physical messagers such as pressure, electric field, magnetic field,
or radiation?  Here I list some of what I read and thought, and I welcome
anybody point me to right review papers or any sort of recommendation.

1. a recent paper (Albrecht-Buehler, PNAS, vol 89, p8288) showes that BHK
    cells can communicate with each other via infrared light.  Could this
    also possible in neurons?

2. Alternating electric fields can activate membrane ATPase (Tsong, BBA
    vol 1113, p53).  Can neurons generate electric fields, even transiently,
    during normal situation, such as depolarization?

3. What about magnetic field?  There are some works on the influence of
    of magnetic field over normal cellular physiologies,  but most, if not
    all, of the studies arise from an enviromental concern, or medical
    technologies.  Does a neuron have a magnetic field? and can it change?
4.  There are stretch receptors, which could sense pressure, but can
    cells generate pressure on the surface of other cells?

    All of these questions point to a central question that whether cells
are able to exploit some physical measures to communicate.

Hans Xie
e-mail, gwu5042@gwuvm.gwu.edu
From: druhanj@HAL.HAHNEMANN.EDU
Newsgroups: bionet.neuroscience
Subject: RE: Lastest on Halperidol?
Date: 28 Dec 92 16:42:24 GMT
Distribution: bionet

Haloperidol also appears to be a high-affinity ligand at sigma binding sites.
In fact, the term "haloperidol-sensitive sigma receptor" has recently been
coined to describe a subclass of sigma sites that appear to be distinct from
other PCP- or opiate-associated sites. I have not been following the sigma
story very closely, and I'm not sure whether the physiological and functional
consequences of haloperidol's actions at the sigma site have been determined.
Perhaps you could run a Medline search on Sigma receptors and haloperidol to
get the latest info on this topic

Jon Druhan
Newsgroups: bionet.neuroscience
From: carter_r@synapse.bms.com (Richard B. Carter)
Subject: Re: 5-HT Receptors
Organization: Bristol-Myers Squibb PRI
Date: Wed, 23 Dec 1992 13:17:07 GMT

Serotonin: Molecular Biology, Receptors, and Functional Effects.  J.R. Fozard 
& P.R. Saxena (eds.) Birkhauser Verlag, Berlin, 1991.  ISBN: 3-7643-2607-7

The Neuropharmacology of Serotonin.  P.M. Whitaker-Azmitia & S.J. Perouka 
(eds.) Ann. N.Y. Acad. Sci., Vol. 600, 1990.

Enjoy!


-- 
*******************************************************************************
R.B. Carter                                          Internet: Carter_R@bms.com
Newsgroups: bionet.neuroscience
From: andrew@uaneuro.uah.ualberta.ca (Andrew Penn)
Subject: Re: Lastest on Halperidol?
Reply-To: euro.uah.ualberta.ca (Andrew Penn)
Organization: University Of Alberta, Edmonton Canada
Date: Fri, 1 Jan 1993 02:19:10 GMT

In article <1992Dec26.013818.8234@ringer.cs.utsa.edu>  
senseman@lucy.brainlab.utsa.edu (David M. Senseman) writes:
> Haloperidol is a rather "old" dopamine blocker (=antagonist).
> As I understand it, it doesn't differentiate between D1 and D2
> receptors and in certain systems atleast, it has cross reactivity
> with serotonin. 
> 
> The reason I'm asking? We recently did some experiments in which
> Haloperidol reduced a rather interesting neuophysiological process
> (maybe you'll read about it in Science?   :-)   Anyway, I would
> appreciate any info on Halperidol that the wizards on  
bionet.neuroscience
> care to share. 
> 
> Thanks. (and Merry Christmas :-)
> -- 
> David M. Senseman, Ph.D.     | A man who has never gone to school may  
steal 
> (senseman@lonestar.utsa.edu) | from a freight car; but if he has a  
university
> Division of Life Sciences    | education, he may steal the whole  
railroad.
> UT San Antonio               |             Theodore Roosevelt  
(1858-1919)

Work at the University of Saskatchewan has suggested that survival of  
hypoxic neurons is compromised by Haloperidol. What was the process..?
	Andrew Penn
	Neurology
	University of Alberta
From: merlin@neuro.usc.edu (merlin)
Newsgroups: bionet.neuroscience
Subject: COMA induction agents
Date: 2 Jan 1993 21:35:47 -0800
Organization: University of Southern California, Los Angeles, CA
NNTP-Posting-Host: neuro.usc.edu

Could anyone suggest an agent which reliably induces an irreversible 
coma in acute subjects without incuring significant collateral damage.  

Such an agent would potentially be usefull for acute experiments in
the absence of general anesthesia and/or decerebration.
From: NOVOTNY%MRCBS@BIOMED.MED.YALE.EDU (RUSTY)
Newsgroups: bionet.neuroscience
Subject: Subscribe
Date: 23 Dec 92 00:33:19 GMT
Distribution: bionet

Subscribe
From: lmk2@garnet.berkeley.edu (Leslie Kay)
Newsgroups: bionet.neuroscience
Subject: Re: unconventional communication
Date: 30 Dec 1992 19:57:54 GMT
Organization: University of California, Berkeley
Distribution: bionet
NNTP-Posting-Host: garnet.berkeley.edu

In article <9212262154.AA14329@net.bio.net> GWU5042@GWUVM.GWU.EDU (Hans Xie) writes:
>
>2. Alternating electric fields can activate membrane ATPase (Tsong, BBA
>    vol 1113, p53).  Can neurons generate electric fields, even transiently,
>    during normal situation, such as depolarization?
>
>3. What about magnetic field?  There are some works on the influence of

EEG and field potentials are created by the fluctuating currents of masses
of neurons, the dendritic current arises in connection with the spike
initiating zone on the neuron.  In populations of neurons, especially
those lined up in parallel, a summation effect is produced, which can
be measured at the surface of the brain, the scalp, or with deep electrodes
implanted directly in the cortex.  Every electric field has its associated
magnetic field, but it is not clear if either of these has a functional
role.  Some people refer to these as just the "noise" generated by the
neural masses, which are helpful to us in trying to decipher what is
going on in neural processing.

I do not have them handy, but there are several references by Walter
Freeman which explain the formation of EEG from masses of neurons.

Leslie Kay
UCB Biophysics
lmk2@garnet.berkeley.edu
From: HXIE@MACC.WISC.EDU (HUIWEN XIE)
Newsgroups: bionet.neuroscience
Subject: help
Date: 29 Dec 92 18:26:00 GMT
Distribution: bionet

I need someone ( anyone ) to help me clarify some electrophysiological terms.
1. How to define junction current (when sharp ro patch electrodes are used ) and
how to measure it;
2. What is electrotonic length and how to measure it;
3. When we measure input resistance o f a neuron we usually insert an electrode
into soma and inject a small amount of hyperpolarizing current into soma and
monitor the change in voltage. In so doing,does the value obtained for input
resistance only represent the resistance of soma not including whole cell ?
4. It has been shown that no antidromic action potential can be induced in rat
spinal motoneuron until
embryonic day 16. However, action potentail can be (i) evoked by injecting
depolarizing current into soma intracellularly as early as E14. Can anyone
overthere provide a plausible explanation for this phenomenon.
 
Thanks in advance.
 
Huiwenl
Newsgroups: bionet.neuroscience
From: senseman@lucy.brainlab.utsa.edu (David M. Senseman)
Subject: Lastest on Halperidol?
Organization: University of Texas at San Antonio
Date: Sat, 26 Dec 1992 01:38:18 GMT

Haloperidol is a rather "old" dopamine blocker (=antagonist).
As I understand it, it doesn't differentiate between D1 and D2
receptors and in certain systems atleast, it has cross reactivity
with serotonin. 

The reason I'm asking? We recently did some experiments in which
Haloperidol reduced a rather interesting neuophysiological process
(maybe you'll read about it in Science?   :-)   Anyway, I would
appreciate any info on Halperidol that the wizards on bionet.neuroscience
care to share. 

Thanks. (and Merry Christmas :-)
-- 
David M. Senseman, Ph.D.     | A man who has never gone to school may steal 
(senseman@lonestar.utsa.edu) | from a freight car; but if he has a university
Division of Life Sciences    | education, he may steal the whole railroad.
UT San Antonio               |             Theodore Roosevelt (1858-1919)
Newsgroups: bionet.neuroscience
From: rs69@cunixb.cc.columbia.edu (Rong Shen)
Subject: intelligence in lower animals
Organization: Columbia University
Date: Sun, 27 Dec 1992 02:27:58 GMT

Hi,

	I have been contemplating a phenomenon about intelligence:
When a frog sees a mosquito and the mosquito flies away, the frog
would follow the mosquito (to eat it, of course). Would you say that
the frog has intelligence?

	This question seems silly, but I really want to know what you
think. Thanks a lot.

--
rs69@cunixb.cc.columbia.edu
From: theron@reed.edu (Scott Buckley)
Newsgroups: bionet.neuroscience
Subject: Re: 5-HT Receptors
Date: 23 Dec 92 07:00:00 GMT
Distribution: bionet
Original-To: cabot.balltown.cma.COM@com.cma.balltown.cabot, connoll{@edu.reed
Original-Cc: neur-sci@uk.ac.daresbury

It's just a tad dated, but I'm still fond of 

Marsden, CA, et al. (1989) Functional identification of 5HT receptor subtypes. 
Comp. Review Biochem. Physiol.  93A(1):107-114

This is a comprehensive tour though serotonin receptor subtypes & their
specializations as of approx. 3 years ago.

Also, almost anything at all by G. Aghajanian would be interesting.  Try:

{Aghajanian, G. K. (1987) Serotonin. In Encyclopedia of Neuroscience, 
F. Adel, ed.  Cambridge, Mass., Birkhauser, p. 1082.

Aghajanian, G. K. et al. (1987) Physiology of the midbrain serotonin system. 
In Psychopharmacology, The Third Generation of Progress, 
Herbert Y. Meltzer, ed.  Raven Press, New York, pp. 141-149.

I'm sure other readers will add lots of others.

Good Luck! (& Happy New Year to all!)

Scott Buckley
RS Dow Inst. of Neurological Science (Portland, Oregon)
theron@reed.edu

{{
{.
Newsgroups: bionet.neuroscience
From: connolly@cabot.balltown.cma.COM (Ian Connolly)
Subject: 5-HT Receptors
Organization: New York State Institute for Sebastian Cabot Studies
Date: Tue, 22 Dec 1992 20:31:44 GMT

I'm looking for anything (article or book) which has a good overview
of serotonin receptors.  The references I have right now seem to treat
them as something of a mystery.  *Any* information would be appreciated.
Thanks...

				-CC
	-	-	-	-	-	-	-
Christopher Ian Connolly			connolly@cs.umass.edu
Laboratory for Perceptual Robotics		wa2ifi
University of Massachusetts at Amherst		Amherst, MA 01003
From: zrsung@INSECT.BERKELEY.EDU
Newsgroups: bionet.genome.arabidopsis
Subject: Postdoctoral position available
Date: 2 Jan 93 17:29:30 GMT
Distribution: bionet

A postdoctoral position supported by the NIH Postdoctoral Training Grant
is available to study meristem ontogeny and function in Arabidopsis. We
have recently isolated a large number of Arabidopsis mutants that are
impaired in seedling development. Three categories of mutants have been
identified: 1) embryo pattern mutants (Mayer et al., 1991, Nature
353:402), 2) mutants impaired in shoot meristem development and
function, e.g. emf (Sung et al., 1992, Science 258:1645), and 3) mutants
impaired in root meristem development. Interested candidates should
contact Professor Renee Sung, Department of Plant Biology, University of
California, Berkeley, CA 94720. Tel:(510) 642-6966, Fax:(510) 642-4995.
From: kristoff@NET.BIO.NET (David Kristofferson)
Newsgroups: bionet.genome.arabidopsis
Subject: BIOSCI/bionet Frequently Asked Questions
Date: 3 Jan 93 10:00:02 GMT
Distribution: bionet


New users of BIOSCI/bionet may want to read the "Frequently Asked
Questions" or "FAQ" sheets for BIOSCI.  There are two FAQ sheets for
the newsgroup system.  FAQ I describes the general purpose and uses of
the BIOSCI/bionet newsgroups.  FAQ II provides details on how to
participate in these forums.  Both of these FAQs are available for
anonymous FTP from net.bio.net [134.172.2.69] in
pub/BIOSCI/biosci1.FAQ and pub/BIOSCI/biosci2.FAQ.  They may also be
requested by sending e-mail to biosci@net.bio.net (use plain English
for your request).  The FAQs are also posted on the first of each
month to the newsgroup BIONEWS/bionet.announce immediately following
the posting of the BIOSCI information sheet.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				kristoff@net.bio.net
From: zrsung@INSECT.BERKELEY.EDU
Newsgroups: bionet.genome.arabidopsis
Subject: markers and YACs for chromosome 5
Date: 22 Dec 92 17:10:07 GMT
Distribution: bionet

Dear members of Arabidopsis community,
I'm in a desperate need of new (not listed on H. Goodman &
E.Meyerowitz maps) RFLP markers on chromosome 5.They should be close to
the RFLP  marker m247. 
Also, I'm  looking for YAC clones for the marker m247.
Any information regarding this matter will be appreciated.
/ Chang-Hsien Yang, Dept.of Plant Biology, UC Berkeley /