From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human gene for 92-kDa type IV collagenase
Date: 9 Jan 93 05:46:46 GMT
Distribution: bionet
Checksum: 20684 5

LOCUS       HUMIVCOL92   2226 bp ds-DNA             PRI       09-JAN-1993
DEFINITION  Human gene for 92-kDa type IV collagenase
ACCESSION   D10051
KEYWORDS    92-kDa type IV collagenase.
SOURCE      Homo sapiens peripheral blood DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Huhtala,P., Tuuttila,A., Chow,L.T., Lohi,J., Keski-Oja,J. and
            Tryggvason,K.
  TITLE     Complete Structure of the Human Gene for 92-kDa Type IV Collagenase
  JOURNAL   J. Biol. Chem. 266, 16485-16490 (1991)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Sato,H. and Seiki,M.
  TITLE     Synergistic cooperation of Ap-1 proteins with NFkB-like and
            Sp-1-like factors mediates 12-0-tetradecanoyl-phorbol-13-acetate
            (TPA) and tumour necrosis factor a (TNFa)-induced 92-kDa type IV
            collagenase gene expression
  JOURNAL   Oncogene (1993) In press
  STANDARD  full automatic
COMMENT     Submitted (06-Dec-1991) to DDBJ by: Hiroshi Sato Department of
            Virology Cancer Research Institute, Kanazawa University 13-1
            Takaramach Kanazawa 920 Japan Phone:  0762-62-8151x5292 Fax:
            0762-60-7840.
FEATURES             Location/Qualifiers
     misc_signal     2144..2148
                     /note="TATA box"
     primer_bind     2173
                     /note="transcription start site"
     exon            2192..>2194
                     /partial
                     /number=1
                     /product="92-kDa type IV collagenase"
BASE COUNT      574 a    548 c    573 g    531 t
ORIGIN      
        1 aagcttcaga gccaggcagt tctgggcttg aacactagtt ctgtggatta actcgctctg
       61 tgatcacagg caaattcctt aactctctga gccttagttt ccccctctga aaacaggagg
      121 gatactcatt aaacttacct tacaggtggt gaggatgaaa cgagaggctt atagagaact
      181 tattacggtg cttgacacag taaatctcaa aaaatgcatt attattatta tggttcagag
      241 gtaaagtgac ttgcccaagg tcacatagct ggaaaatgca gagccgggat ggaaatccag
      301 gacttcgtga cgcaaagcag atgttcattg gttagtgaac tttagaactt caacttttct
      361 gtaaaggaag ttaattatct ccatctcaca gtctcattta ttagataagc atataaaatg
      421 cctggcacat agtaggccct ttaaatacag cttattgggc cgggcgccat gctcatgccc
      481 gtaatcctag cactttggga ggccaggtgg gcagatcact tgagtcagaa gttcgaaacc
      541 agcctggtca acgtagtgaa accccatctc tactaaaaat acaaaaaatt tagccaggcg
      601 tggtggcgca cctataatac cagctactcg ggaggctgag gcaggagaat tgcttgaacc
      661 cgggaggcag atgttgcagt gagccgagat cacgccactg cactccagcc tgggtgacag
      721 agtgatacta ccccccccaa aaataaaata aaataaataa atacaacttt ttgagttgtt
      781 agcaggtttt tcccaaatag ggctttgaag aaggtgaata tagaccctgc ccgatgccgg
      841 ctggctagga agaaaggagt gagggaggct gctggtgtgg gaggcttggg agggaggctt
      901 ggcataagtg tgataattgg gcctggagat ttggctgcat ggaggcaggg ctggaggaac
      961 taagggctcc tatagattat ttccccatat cctgccgcaa tttgcagttg aagaatccta
     1021 agctgagaaa ggggaggcat ttactccagg ttacactgca gcttagagcc caataacctg
     1081 gtttggtgat tccaagttag aatcatggtc ttttggcagg gtctcgctct gttgcccagg
     1141 ctggagtgca gtgacataat catggctcac tgtatccttg accttctttc tgggctcaag
     1201 caatcctccc acctcggcct cccaaagtgc taagattaca ggaatgagcc accatacctg
     1261 gccctgaatc ttgggtcttg gccttagtaa ttaaaaccaa tcaccaccat ccgttgcgga
     1321 cttacaacct acagtgttct aaacatttta tatgtttgat ctcatttaat cctcacatca
     1381 atttagggac aaagagcccc ccaccccccg tttttttttt tacagctgag gaaacacttc
     1441 aaagtggtaa gacatttgcc cgaggtcctg aaggaagaga gtaaagccat gtctgctgtt
     1501 ttctagaggc tgctactgtc ccctttactg ccctgaagat tcagcctgcg gaagacaggg
     1561 ggttgcccca gtggaattcc ccagccttgc ctagcagagc ccattccttc cgcccccaga
     1621 tgaagcaggg agaggaagct gagtcaaaga aggctgtcag ggagggaaaa agaggacaga
     1681 gcctggagtg tggggagggg tttggggagg atatctgacc tgggaggggg tgttgcaaaa
     1741 ggccaaggat gggccagggg gatcattagt ttcagaaaga agtctcaggg agtcttccat
     1801 cactttccct tggctgacca ctggaggctt tcagaccaag ggatggggga tccctccagc
     1861 ttcatccccc tccctccctt tcatacagtt cccacaagct ctgcagtttg caaaacccta
     1921 cccctcccct gagggcctgc ggtttcctgc gggtctgggg tcttgcctga cttggcagtg
     1981 gagactgcgg gcagtggaga gaggaggagg tggtgtaagc cctttctcat gctggtgctg
     2041 ccacacacac acacacacac acacacacac acacacacac acaccctgac ccctgagtca
     2101 gcacttgcct gtcaaggagg ggtggggtca caggagcgcc tccttaaagc ccccacaaca
     2161 gcagctgcag tcagacacct ctgccctcac catgagcctc tggcagcccc tggtcctggt
     2221 gctcct
//