From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rabbit cytochrome P450 gene, clone pP450PBc1, 3' end.
Date: 31 Jul 92 10:01:58 GMT
Distribution: bionet
Checksum: 40399     5

LOCUS       RABCY450B    1798 bp ss-mRNA            MAM       31-JUL-1992
DEFINITION  Rabbit cytochrome P450 gene, clone pP450PBc1, 3' end.
ACCESSION   K01522
KEYWORDS    cytochrome; cytochrome P-450;
            phenobarbital-induced cytochrome P-450.
SOURCE      Rabbit (48 hour phenobarbital-exposed New Zealand adult male)
            liver, cDNA to mRNA, clone pP450PBc1.
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Lagomorpha; Leporidae.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Leighton,J.K. and DeBrunner-Vossbrinck,B.A.
  TITLE     Isolation and sequence analysis of three cloned cDNAs for rabbit
            liver proteins that are related to rabbit cytochrome P-450 (form
            2), the major phenobarbital-inducible form
  JOURNAL   Biochemistry 23, 204-210 (1984)
  STANDARD  simple staff_entry
COMMENT     The sequences of 3 different rabbit cytochrome P-450 cDNAs were
            compared with each other and with a rat cytochrome P-450 gene [1].
            Rabbit and rat showed about 55-60% homology.
FEATURES             Location/Qualifiers
     CDS             <1..1443
                     /note="cytochrome P-450"
                     /codon_start=1
                     /translation="LSCLLLLSLWKQSYGGGKLPPGPTPFPILGNILQIGIQDISKSF
                     TKLSEVYGPVFTVYLGMKPTVVIHGYDAVKEALVDLGEEFSGRIVFPLTAKINKGYGI
                     VFSNGKRWKETRRFSLMTLRDFGMGKRSIEDRVQEEARCLVEELRKTNGSPCNPTFIL
                     GAAPCNVICSVIFQNRFDYTDQDFLSLMGKLNENFKILNSPWVQMCNNFPILIDYLPG
                     SHNKILRNNIYIRNYVLEKIKEHQETLDINNPRDFIDCFLIKMEQEKDNQQSEFTIEN
                     LMTTLSDVFGAGTETTSTTLRYGLLLLMKHPEVIAKVQEEIERVIGRHRSPCMQDRSR
                     MPYTDATVHEIQRYINLIPNNVPRATTCNVKFRSYLIPKGTAVITSLTSMLYNDKEFP
                     NPDRFDPGHFLDASGKFRKSDYFMPFSTGKRVCVGEVLARMELFLFLTAILQNFTPKP
                     LVDPKDIDTTPLVSGLGRVPPLYQLSFIPA"
BASE COUNT      482 a    439 c    395 g    482 t
ORIGIN      52 bp upstream of HindIII site.
        1 ctctcctgtt tgcttctcct ttcactctgg aaacagagct atgggggagg gaagcttcct
       61 cctggaccca ctccttttcc aattcttgga aatattctgc agataggtat tcaagacatc
      121 agcaaatcct tcaccaaact gtcagaagtc tatggccctg tgttcactgt gtatttgggc
      181 atgaagccca ccgtggtgat acatggatat gatgcagtga aagaagcctt ggttgatctg
      241 ggagaagagt tttccggaag aatcgttttc ccactgactg caaaaattaa taaaggatat
      301 ggaatcgttt tcagcaatgg aaagagatgg aaggagaccc ggcgcttctc gctcatgacc
      361 ctgcgggatt tcggaatggg gaagaggagc attgaggacc gagttcaaga ggaggcccgc
      421 tgcctggtgg aggaactgag aaaaaccaac ggctctccct gcaatcccac atttatcctg
      481 ggtgctgctc cctgcaacgt gatctgctcc gtgattttcc agaaccgttt tgattacaca
      541 gaccaggatt ttcttagctt gatgggaaag ttgaatgaaa acttcaagat tctgaattcc
      601 ccctgggtac agatgtgcaa taatttccct attcttattg attatctccc cggaagtcat
      661 aacaaaatac ttagaaataa tatttatata agaaactatg ttttggagaa aataaaggaa
      721 caccaagaaa ccctggatat taacaatcct cgagacttca ttgattgttt cctgatcaaa
      781 atggaacagg aaaaggacaa ccaacagtct gaatttacca ttgaaaacct gatgaccaca
      841 ctgagtgatg tgtttggagc tggaacagag accacaagca ccaccctgag gtatggactc
      901 ctgctcctga tgaagcaccc agaggtcata gctaaagtgc aggaggagat tgagcgtgtg
      961 attggccgac accggagccc ctgcatgcag gacaggagcc gcatgcccta cacggatgcc
     1021 acggtgcacg agatccagag atacattaac ctcatcccca acaacgtgcc ccgtgcaaca
     1081 acctgtaacg ttaaattcag gagctacctc attcccaagg gcacggctgt aataacatca
     1141 ctgacttcta tgctgtacaa cgacaaagaa ttcccgaacc cagacagatt tgaccctggc
     1201 cacttcctgg atgctagcgg caagtttagg aaaagtgact acttcatgcc tttctcaaca
     1261 ggaaagcgag tgtgtgtggg agaggtcctg gcccgcatgg agctgttttt attcctgact
     1321 gccattctgc agaactttac cccgaagcct ctggttgacc caaaggacat tgacaccacc
     1381 ccacttgtca gtgggctagg tcgtgtgcca cccttgtacc agctcagctt cattcctgcc
     1441 tgaagaaggg caggccacgt ggctgctgct gagctgtcat ctgcagctcc tctcttccag
     1501 gcaccataca actccttccc ctatcatggg tcccttccct gacatatcct ctgacatttc
     1561 ctcatttctc aatatccaac ctccatttgg gagaattttt tggggtctct tcacaaatat
     1621 gtgtctactg ttccttatat tctgtgactc ttggaatgac caccacatag gctaattcct
     1681 atctaatgct aatttttttt tatgttatca ctgtaaaatt gagcaagatg attggtattt
     1741 ggcaatttag agccatttct tctcttcctg ttctaaatag aagcatcatt aattgttg
//