From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human fetal liver c-myc proto-oncogene, exon 1 and flanks.
Date: 22 Aug 92 10:01:01 GMT
Distribution: bionet
Checksum: 37045     4

LOCUS       HUMMYCF01    1365 bp ds-DNA             PRI       22-AUG-1992
DEFINITION  Human fetal liver c-myc proto-oncogene, exon 1 and flanks.
ACCESSION   K00559
KEYWORDS    c-myc oncogene; chromosomal translocation; constant region;
            gene activation; heavy chain mu switch region; myc oncogene;
            proto-oncogene; transforming gene.
SEGMENT     1 of 3
SOURCE      Human fetal liver DNA (library of R. Dalla-Favera), clone
            lambda-MC41.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Watt,R., Nishikura,K., Sorrentino,J., Ar-Rushdi,A., Croce,C.M. and
            Rovera,G.
  TITLE     The structure and nucleotide sequence of the 5' end of the human
            c-myc oncogene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 80, 6307-6311 (1983)
  STANDARD  full staff_review
COMMENT     The myc gene is the cellular homologue of the transforming gene
            carried by the avian myelocytomatosis virus MC29. Unlike the ras
            proto-oncogenes which obtain transforming potential through
            mutations within their coding exons (namely mutations within codon
            12), the myc gene identified as the cause of Burkitt lymphomas
            acquires its transforming potential through defects of either
            transcriptional or translational control. Thus it is not an altered
            gene product that induces tumors, but a normal product that is
            present either in the wrong quantity or at the wrong time in the
            life cycle of the cell.
            [1] uses the hybridization to fragments of these clones of various
            mRNA 5' ends to reasssign the transcription initiation site given
            by Colby et al. (1983) Nature 301, 722-725.
            See other human c-myc entries.
FEATURES             Location/Qualifiers
     prim_transcript 183..>1365
                     /note="c-myc mRNA (alt.)"
                     /gene="MYC"
     prim_transcript 346..>1365
                     /note="c-myc mRNA (alt.)"
     intron          740..>1365
                     /note="c-myc intron a"
BASE COUNT      268 a    393 c    396 g    308 t
ORIGIN      81 bp upstream of SmaI site, on chromosome 8q24.
        1 agctagagtg ctcggctgcc cggctgagtc tcctccccac cctcccccac cctccccacc
       61 ctccccataa gcgcccctcc cgggttccca aagcagaggg cgtgggggaa aagaaaaaag
      121 atcctctctc gctaatctcc gcccaccggc cctttataat gcgagggtct ggacggctga
      181 ggacccccga gctgtgctgc tcgcggccgc caccgccggg ccccggccgt ccctggctcc
      241 cctcctgcct cgagaagggc agggcttctc agaggcttgg cgggaaaaaa gaacggaggg
      301 agggatcgcg ctgagtataa aagccggttt tcggggcttt atctaactcg ctgtagtaat
      361 tccagcgaga ggcagaggga gcgagcgggc ggccggctag ggtggaagag ccgggcgagc
      421 agagctgcgc tgcgggcgtc ctgggaaggg agatccggag cgaatagggg gcttcgcctc
      481 tggcccagcc ctcccgcttg atcccccagg ccagcggtcc gcaacccttg ccgcatccac
      541 gaaactttgc ccatagcagc gggcgggcac tttgcactgg aacttacaac acccgagcaa
      601 ggacgcgact ctctcgacgc ggggaggcta ttctgcccat ttggggacac ttccccgccg
      661 ctgccaggac ccgcttctct gaaaggctct ccttgcagct gcttagacgc tggatttttt
      721 tcgggtagtg gaaaaccagg taagcaccga agtccacttg ccttttaatt tattttttta
      781 tcactttaat gctgagatga gtcgaatgcc taaatagggt gtcttttctc ccattcctgc
      841 gctattgaca cttttctcag agtagttatg gtaactgggg ctggggtggg gggtaatcca
      901 gaactggatc ggggtaaagt gacttgtcaa gatgggagag gagaaggcag agggaaaacg
      961 ggaatggttt ttaagactac cctttcgaga tttctgcctt atgaatatat tcacgctgac
     1021 tcccggccgg tcggacattc ctgctttatt gtgttaattg ctctctgggt tttggggggc
     1081 tgggggttgc tttgcggtgg cagaaagccc cttgcatcct gagctccttg gagtagggac
     1141 cgcatatcgc ctgtgtgagc cagatcgctc cgcagccgct gacttgtccc cgtctccggg
     1201 agggcattta aatttcggct caccgcattt ctgacagccg gagacggaca ctcggcgtcc
     1261 cgcccgcctg tccccgcggc gattccaacc cgccctgatc cttttaagaa gttggcattt
     1321 ggctttttaa aaagcaataa tacaatttaa aacctgggtc tctag
//