From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human CD11b (MAC-1/Mo1/CR3) leukocyte adhesion receptor alpha
Date: 10 Sep 92 10:32:52 GMT
Distribution: bionet
Checksum: 07742     9

LOCUS       HUMLAPA      3595 bp ss-mRNA            PRI       10-SEP-1992
DEFINITION  Human CD11b (MAC-1/Mo1/CR3) leukocyte adhesion receptor alpha
            subunit mRNA, partial cds.
ACCESSION   M18044 J03270 M19664 X07421
KEYWORDS    alpha chain; complement receptor 3; integrin;
            leukocyte adhesion glycoprotein; leukocyte adhesion receptor.
SOURCE      Human monocyte and peripheral blood lymphocyte, cDNA to mRNA, clone
            5B.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Arnaout,M.M., Gupta,S.K., Pierce,M.W. and Tenen,D.G.
  TITLE     Amino acid sequence of the alpha subunit of human leukocyte
            adhesion receptor Mol (complement receptor type 3)
  JOURNAL   J. Cell Biol. 106, 2153-2158 (1988)
  STANDARD  full staff_entry
REFERENCE   2  (bases 2821 to 3208)
  AUTHORS   Arnaout,M.A., Remold-O'Donnell,E., Pierce,M.W., Harris,P. and
            Tenen,D.G.
  TITLE     Molecular cloning of the alpha subunit of human and guinea pig
            leukocyte adhesion glycoprotein Mo1: Chromosomal localization and
            homology to the alpha subunits of integrins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85, 2776-2780 (1988)
  STANDARD  full staff_entry
COMMENT     Draft entry and printed copy of sequence for [2],[1] kindly
            provided            by M.A.Arnaout, 25-Apr-1988.
FEATURES             Location/Qualifiers
     CDS             76..3533
                     /note="leukocyte adhesion glycoprotein precursor"
                     /gene="LYAM1"
                     /codon_start=1
                     /translation="MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGS
                     RVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQL
                     LACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGS
                     IIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPI
                     TQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEAD
                     REGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFA
                     IEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINM
                     TRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKG
                     TQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAV
                     LYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPS
                     HSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIM
                     EFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDS
                     GRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGT
                     PLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPR
                     EFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVS
                     GALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTE
                     FQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSPPISLVFL
                     VPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRI
                     QCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAF
                     VRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGP
                     PGAEPQ"
                     /partial
     sig_peptide     76..123
                     /note="leukocyte adhesion glycoprotein signal peptide"
                     /codon_start=1
     mat_peptide     124..3531
                     /note="leukocyte adhesion glycoprotein"
                     /codon_start=1
BASE COUNT      809 a   1034 c    993 g    759 t
ORIGIN      Chromosome 16.
        1 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc
       61 tggctccttc cagccatggc tctcagagtc cttctgttaa cagccttgac cttatgtcat
      121 gggttcaact tggacactga aaacgcaatg accttccaag agaacgcaag gggcttcggg
      181 cagagcgtgg tccagcttca gggatccagg gtggtggttg gagcccccca ggagatagtg
      241 gctgccaacc aaaggggcag cctctaccag tgcgactaca gcacaggctc atgcgagccc
      301 atccgcctgc aggtccccgt ggaggccgtg aacatgtccc tgggcctgtc cctggcagcc
      361 accaccagcc cccctcagct gctggcctgt ggtcccaccg tgcaccagac ttgcagtgag
      421 aacacgtatg tgaaagggct ctgcttcctg tttggatcca acctacggca gcagccccag
      481 aagttcccag aggccctccg agggtgtcct caagaggata gtgacattgc cttcttgatt
      541 gatggctctg gtagcatcat cccacatgac tttcggcgga tgaaggagtt tgtctcaact
      601 gtgatggagc aattaaaaaa gtccaaaacc ttgttctctt tgatgcagta ctctgaagaa
      661 ttccggattc actttacctt caaagagttc cagaacaacc ctaacccaag atcactggtg
      721 aagccaataa cgcagctgct tgggcggaca cacacggcca cgggcatccg caaagtggta
      781 cgagagctgt ttaacatcac caacggagcc cgaaagaatg cctttaagat cctagttgtc
      841 atcacggatg gagaaaagtt tggcgatccc ttgggatatg aggatgtcat ccctgaggca
      901 gacagagagg gagtcattcg ctacgtcatt ggggtgggag atgccttccg cagtgagaaa
      961 tcccgccaag agcttaatac catcgcatcc aagccgcctc gtgatcacgt gttccaggtg
     1021 aataactttg aggctctgaa gaccattcag aaccagcttc gggagaagat ctttgcgatc
     1081 gagggtactc agacaggaag tagcagctcc tttgagcatg agatgtctca ggaaggcttc
     1141 agcgctgcca tcacctctaa tggccccttg ctgagcactg tggggagcta tgactgggct
     1201 ggtggagtct ttctatatac atcaaaggag aaaagcacct tcatcaacat gaccagagtg
     1261 gattcagaca tgaatgatgc ttacttgggt tatgctgccg ccatcatctt acggaaccgg
     1321 gtgcaaagcc tggttctggg ggcacctcga tatcagcaca tcggcctggt agcgatgttc
     1381 aggcagaaca ctggcatgtg ggagtccaac gctaatgtca agggcaccca gatcggcgcc
     1441 tacttcgggg cctccctctg ctccgtggac gtggacagca acggcagcac cgacctggtc
     1501 ctcatcgggg ccccccatta ctacgagcag acccgagggg gccaggtgtc cgtgtgcccc
     1561 ttgcccaggg ggagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa
     1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg
     1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt
     1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag
     1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg
     1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag
     1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta
     1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc
     2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact
     2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag
     2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa
     2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc
     2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat
     2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc
     2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt
     2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg
     2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag
     2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg
     2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca
     2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg
     2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc
     2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc
     2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat
     2941 caggtcagca acctggggca gaggagcccc cccatcagcc tggtgttctt ggtgcccgtc
     3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg
     3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg
     3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg
     3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg
     3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac
     3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc
     3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg
     3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg
     3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc
     3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgt
//