From: tls@panix.com (Thor Lancelot Simon)
Subject: Re: UL: Monumental LSD overdose taken
Date: Mon, 14 Dec 1992 03:57:35 GMT
Organization: PANIX Public Access Unix & Internet, NYC

In article <92348.035039U56673@uicvm.uic.edu> <U56673@uicvm.uic.edu> writes:
A
>OK... lets go over this one more time.  THIS time I did do a little research.
>Not because i actually care wether or not i am believed to be a compitent chemi
>st (i make no such claims), but because it was CONVIENIENT!
>"Pharmaceutical Dosage Forms and Drug Delivery Systems.  Howard C. Ansel,
>Nicholas G. Popovich fifth ed- page 310.
>the following is an exacti quote (minus spelling and typos of course)
>A number of agents are credited with enhanceing skin penetration:
>Dimethylacetamide, dimethylformaldyhyde,alchohol, propyleneglycol, poly ethylen
>e glycol.
>According to the book there are many different brands of nitro-patch all of the
>m contain one of these penetration enhancers and a semi-permeaple membrain to c
>ontrol flow rate.  As far as i can tell another one of these is poly iso butyle
>ne.  acetone was also mentioned on a sseparate list in the book.
>
>Sweat, sylyva, extra are NOT water.  they contain many other things like urea-
>various oils, salts ect.
>
>The reason you dont lyce when you swim is many fold..... just a few
>the skin has a sebacoius layer (oils)
>as skin cells dy thier organelles deteriorate.  this causes (to complex to expn
>ow) the cell to flatten and become hard (and also very dead and water insoluble
>)  it is pushed out be new cells.  this forms the outer dermis.  Ps once
>these skin layers are passed.  the job of osmotic controll is taken up by compl
>ex salt buffers.  once the skin barier is broken, the durg can be distributed v
>ia blood to all parts of the body (this last part is also in the referanced boo
>k)
>
>Malcalypse -  resents being called a weekend chemist (indirectly).  We bio peop
B
>le have to take tons of chemistry.  I think i understand why i am being blasted
>for not doing my homework... me thinks that the slighly rude (at least to me)
>graduate student who spend most of his time in the library looking for ways to
>make his research better should stop roasting his undergraduate contemporary wh
>o never has a need to go to the library.  this is just what i think is happenin
>g here.  Correct me if i am wrong.

You are wrong.

It is considered extremely impolite to post on subjects where you are relying
almost solely upon conjecture as the source of your statements.  Speak not
whereof you know not.  There are a number of competent organic chemists who
participate in this group; when you read a thread and think you _might_ have an
idea what's going on, but aren't really sure, the right thing to do is sit back
and wait for one of them to give some kind of definitive answer, not give it a
first try, catch some flamage, backpedal, give it a second try, catch some
flamage, perhaps adjust your idea finally to something which is more than a
little bit off-subject, but might be in reasonable proximity to reality, and
then bitch and moan about how people are always flaming you just because they
are better at looking things up.

Don't you think, incidentally, that "I never need to go to the library" is a 
rather arrogant statement?  You certainly aren't in any position to flame
other people just because they're more interested in expanding their horizons
than you are.

Finally, your writings might be better received if you took the time to correct
the spelling, capitalization, and grammar.  You come across as either semi-
literate or completely lazy and uninterested, just having some fun tossing
absurd ideas into the metaphorical fish tank to watch the frenzy as bigger
fish eat them for lunch.

-- 
Thor Lancelot Simon	 tls@panix.COM

"Better be careful there.  John might decide to start taking legal action
against people who refuse to buy stuff from him."  --Kevin McBride
Xref: sparky alt.drugs:19678 sci.psychology:4795 alt.dreams:4385 sci.med:22557