From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Homo sapiens osteogenic protein-2 (OP-2) mRNA, complete cds.
Date: 3 Jan 93 22:15:43 GMT
Distribution: bionet
Checksum: 64985 5

LOCUS       HUMOP2A      1842 bp ss-mRNA            PRI       23-DEC-1992
DEFINITION  Homo sapiens osteogenic protein-2 (OP-2) mRNA, complete cds.
ACCESSION   M97016
KEYWORDS    TGF beta-like protein; osteogenic protein-2.
SOURCE      Homo sapiens embryo hippocampus cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chorqata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     OP-2: A new osteogenic protein expressed early in embryogenesis
  JOURNAL   J. Biol. Chem. 267, 25220-25227 (1992)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     sig_peptide     497..553
                     /gene="OP-2"
                     /codon_start=1
     misc_feature    556..1285
                     /standard_name="pro-peptide"
                     /product="osteogenic protein-2"
                     /gene="OP-2"
     mat_peptide     1286..1702
                     /product="osteogenic protein-2"
                     /gene="OP-2"
                     /codon_start=1
                     /note="putative"
     CDS             497..1705
                     /standard_name="pre-pro peptide"
                     /gene="OP-2"
                     /product="osteogenic protein-2"
                     /codon_start=1
                     /translation="MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDV
                     QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRA
                     DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRT
                     LHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL
                     YVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKS
                     NELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC
                     SFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHR
                     NMVVKACGCH"
BASE COUNT      290 a    664 c    605 g    283 t
ORIGIN      
        1 ccacagtggc gccggcagag caggagtggc tggaggagct gtggttggag caggaggtgg
       61 cacggcaggg ctggagggct ccctatgagt ggcggagacg gcccaggagg cgctggagca
      121 acagctccca caccgcacca agcggtggct gcaggagctc gcccatcgcc cctgcgctgc
      181 tcggaccgcg gccacagccg gactggcggg tacggcggcg acagacggat tggccgagag
      241 tcccagtccg cagagtagcc ccggcctcga ggcggtggcg tcccggtcct ctccgtccag
      301 gagccaggac aggtgtcgcg cggcggggct ccagggaccg cgcctgaggc cggctgcccg
      361 cccgtcccgc cccgccccgc cgcccgccgc ccgccgagcc cagcctcctt gccgtcgggg
      421 cgtccccagg ccctgggtcg gccgcggagc cgatgcgcgc ccgctgagcg ccccagctga
      481 gcgcccccgg cctgccatga ccgcgctccc cggcccgctc tggctcctgg gcctggcgct
      541 atgcgcgctg ggcgggggcg gccccggcct gcgacccccg cccggctgtc cccagcgacg
      601 tctgggcgcg cgcgagcgcc gggacgtgca gcgcgagatc ctggcggtgc tcgggctgcc
      661 tgggcggccc cggccccgcg cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct
      721 cttcatgctg gacctgtacc acgccatggc cggcgacgac gacgaggacg gcgcgcccgc
      781 ggagcggcgc ctgggccgcg ccgacctggt catgagcttc gttaacatgg tggagcgaga
      841 ccgtgccctg ggccaccagg agccccattg gaaggagttc cgctttgacc tgacccagat
      901 cccggctggg gaggcggtca cagctgcgga gttccggatt tacaaggtgc ccagcatcca
      961 cctgctcaac aggaccctcc acgtcagcat gttccaggtg gtccaggagc agtccaacag
     1021 ggagtctgac ttgttctttt tggatcttca gacgctccga gctggagacg agggctggct
     1081 ggtgctggat gtcacagcag ccagtgactg ctggttgctg aagcgtcaca aggacctggg
     1141 actccgcctc tatgtggaga ctgaggacgg gcacagcgtg gatcctggcc tggccggcct
     1201 gctgggtcaa cgggccccac gctcccaaca gcctttcgtg gtcactttct tcagggccag
     1261 tccgagtccc atccgcaccc ctcgggcagt gaggccactg aggaggaggc agccgaagaa
     1321 aagcaacgag ctgccgcagg ccaaccgact cccagggatc tttgatgacg tccacggctc
     1381 ccacggccgg caggtctgcc gtcggcacga gctctacgtc agcttccagg acctcggctg
     1441 gctggactgg gtcatcgctc cccaaggcta ctcggcctat tactgtgagg gggagtgctc
     1501 cttcccactg gactcctgca tgaatgccac caaccacgcc atcctgcagt ccctggtgca
     1561 cctgatgaag ccaaacgcag tccccaaggc gtgctgtgca cccaccaagc tgagcgccac
     1621 ctctgtgctc tactatgaca gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt
     1681 ggtcaaggcc tgcggctgcc actgagtcag cccgcccagc cctactgcag ccacccttct
     1741 catctggatc gggccctgca gaggcagaaa acccttaaat gctgtcacag ctcaagcagg
     1801 agtgtcaggg gccctcactc tctgtgccta cttcctgtca gg
//