From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human long-chain fatty acid-Coenzyme A ligase (FACL1) mRNA,
Date: 27 Jan 93 05:47:38 GMT
Distribution: bionet
Checksum: 64842 7

LOCUS       HUMFACAL     3188 bp ss-mRNA            PRI       26-JAN-1993
DEFINITION  Human long-chain fatty acid-Coenzyme A ligase (FACL1) mRNA,
            complete cds.
ACCESSION   L09229
KEYWORDS    acyl-activating enzyme; long-chain acyl-CoA synthetase;
            long-chain fatty acid-Coenzyme A ligase; palmitoyl-CoA ligase.
SOURCE      Homo sapiens liver cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Ghosh,B., Zhang,Y.Z., Barbosa,E. and Singh,I.
  TITLE     Human Palmitoyl-CoA Ligase
  JOURNAL   Unpublished (1993)
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             74..2173
                     /function="activates long chain fatty acids"
                     /EC_number="6.2.1.3"
                     /standard_name="palmitoyl-CoA ligase"
                     /gene="FACL1"
                     /note="ATP-binding domain (bp. 1447..1846)"
                     /product="long-chain acyl-CoA synthetase"
                     /codon_start=1
                     /translation="MQAHELFRYFRMPELVDFRQCVTLPTNTLMGFGAFSRRLTTFWR
                     PRHPKPLKPPWHLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQV
                     SNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEW
                     VIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLI
                     PGLKIIVVMDSYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFT
                     SGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVM
                     LCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTVKRWLLDF
                     ASKRKEADVRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL
                     GCQFYEGYGQTECTAGCCLTMPGDWTTGHVGAPMPCNLIKLGWQLEEMNYMASEGEGE
                     VCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQG
                     EYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEE
                     LCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPEL
                     RNYFRSQIDDLYSIIKV"
BASE COUNT      870 a    716 c    790 g    812 t
ORIGIN      
        1 cgggcagtga cagccggcgc ggatcgcgcg tccacggagg agaatcagct tagagaacta
       61 tcaacacagg acaatgcaag cccatgagct gttccggtat tttcgaatgc cagagctggt
      121 tgacttccga cagtgcgtga ctcttccgac caacacgctt atgggcttcg gagctttttc
      181 cagacgactc accaccttct ggcggccacg ccacccaaaa cccctgaagc cgccatggca
      241 cctctccatg cagtcagtgg aagtggcggg tagtggtggt gcacgaagat ccgcactact
      301 tgacagcgac gagcccttgg tgtatttcta tgatgatgtt acaacattat acgaaggttt
      361 ccagagaggg atacaggtgt caaataatgg cccttgttta ggctctcgga aaccagacca
      421 accctatgaa tggctttcat ataaacaggt tgcagaattg tcggagtgca taggctcagc
      481 actgatccag aagggcttca agactgcccc agatcagttc attggcatct ttgctcaaaa
      541 tagacctgag tgggtgatta ttgaacaagg atgctttgct tattcgatgg tgatcgttcc
      601 actttatgat acccttggaa atgaagccat cacgtacata gtcaacaaag ctgaactctc
      661 tctggttttt gttgacaagc cagagaaggc caaactctta ttagagggtg tagaaaataa
      721 gttaatacca ggccttaaaa tcatagttgt catggactcg tacggcagtg aactggtgga
      781 acgaggccag aggtgtgggg tggaagtcac cagcatgaag gcgatggagg acctgggaag
      841 agccaacaga cggaagccca agcctccagc acctgaagat cttgcagtaa tttgtttcac
      901 aagtggaact acaggcaacc ccaaaggagc aatggtcact caccgaaaca tagtgagcga
      961 ttgttcagct tttgtgaaag caacagagaa tacagtcaat ccttgcccag atgatacttt
     1021 gatatctttc ttgcctctcg cccatatgtt tgagagagtt gtagagtgtg taatgctgtg
     1081 tcatggagct aaaatcggat ttttccaagg agatatcagg ctgctcatgg atgacctcaa
     1141 ggtgcttcaa cccactgtct tccccgtggt tccaagactg ctgaaccgga tgtttgaccg
     1201 aattttcgga caagcaaaca ccaccgtgaa gcgatggctc ttggactttg cctccaagag
     1261 gaaagaagca gacgttcgca gcggcatcat cagaaacaac agcctgtggg accggctgat
     1321 cttccacaaa gtacagtcga gcctgggcgg aagagtccgg ctgatggtga caggagccgc
     1381 cccggtgtct gccactgtgc tgacgttcct cagagcagcc ctgggctgtc agttttatga
     1441 aggatacgga cagacagagt gcactgccgg gtgctgccta accatgcctg gagactggac
     1501 cacaggccat gttggggccc cgatgccgtg caatttgata aaacttggtt ggcagttgga
     1561 agaaatgaat tacatggcgt ccgagggcga gggcgaggtg tgtgtgaaag ggccaaatgt
     1621 atttcagggc tacttgaagg acccagcgaa aacagcagaa gctttggaca aagacggctg
     1681 gttacacaca ggggacatcg gaaaatggtt accaaatggc accttgaaaa ttatcgaccg
     1741 gaaaaagcac atatttaagc tggcacaagg agaatacata gcccctgaaa agattgaaaa
     1801 tatctacatg cgaagtgagc ctgttgctca ggtgtttgtc cacggagaaa gcctgcaggc
     1861 atttctcatt gcaattgtgg taccagatgt tgagacatta tgttcctggg cccaaaagag
     1921 aggatttgaa gggtcgtttg aggaactgtg cagaaataag gatgtcaaaa aagctatcct
     1981 cgaagatatg gtgagacttg ggaaggattc tggtctgaaa ccatttgaac aggtcaaagg
     2041 catcacattg caccctgaat tattttctat cgacaatggc cttctgactc caacaatgaa
     2101 ggcgaaaagg ccagagctgc ggaactattt caggtcgcag atagatgacc tctattccat
     2161 catcaaggtt tagtgtgaag aagaaagctc agaggaaatg gcacagttcc acaatctctt
     2221 ctcctgctga tggccttcat gttgttaatt ttgaatacag caagtgtagg gaaggaagcg
     2281 ttctgtgttt gacttgtcca ttcggggttc ttctcatagg aatgctagag gaaacagaac
     2341 actgccttac agtcacctca gtgttcagac catgtttatg gtaatacaca cttccaaaag
     2401 tagccttaaa aattgtaaag ggatactata aatgtgctaa ttatttgaga cttcctcagt
     2461 ttaaaaagtg ggttttaaat cttctgtctc cctgtttttc taatcaaggg gttaggactt
     2521 tgctatctct gagatgtctg ctacttcgtc gaaattctgc agctgtctgc tgctctaaag
     2581 agtacagtgc tctagaggga agtgttccct ttaaaaataa gaacaactgt cctggctgga
     2641 gatctcacaa gcggaccaga gatcttttta aatccctgct actgtccctt ctcacaggca
     2701 ttcacagaac ccttctgatt cgaagggtta cgaaactcat gttcttctcc agtcccctgt
     2761 ggtttctgtt ggagcataag gtttccagta agcgggaggg cagatccaac tcagaaccat
     2821 gcagataagg agcctctggc aaatgggtgc tgcatcagaa cgcgtggatt ctctttcatg
     2881 gcagatgctc ttggactcgg ttctccaggc ctgattcccc gactccatcc tttttcaggg
     2941 ttatttaaaa atctgcctta gattctatag tgaagacaag catttcaaga aagagttacc
     3001 tggatcagcc atgctcagct gtgacgcctg ataactgtct actttatctt cactgaacca
     3061 ctcactctgt gtaaaggcca acggattttt aatgtggttt tcatatcaaa agatcatgtt
     3121 gggattaact tgcctttttc cccaaaaaat aaactctcag gcaaggcatt tcttttaaag
     3181 ctattccg
//