From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Schistosoma mansoni epidermal growth factor receptor (SER,
Date: 21 Aug 92 10:12:51 GMT
Distribution: bionet
Checksum: 14478     4

LOCUS       SCMEGFRC     1354 bp ss-mRNA            INV       21-AUG-1992
DEFINITION  Schistosoma mansoni epidermal growth factor receptor (SER,
            alternative splice class 4 product) mRNA, complete cds.
ACCESSION   M86398
KEYWORDS    EGF receptor; alternative splicing;
            epidermal growth factor receptor; receptor tyrosine kinase.
SOURCE      Schistosoma mansoni (strain Puerto Rican) male adult cDNA to mRNA.
  ORGANISM  Schistosoma mansoni
            Eukaryota; Animalia; Eumetazoa; Platyhelminthes; Trematoda;
            Digenea; Strigeidida; Strigeata; Schistosomatoidea;
            Schistosomatidae.
REFERENCE   1  (bases 1 to 1354)
  AUTHORS   Shoemaker,C.B., Ramachandran,H., Landa,A., dos Reis,M.G. and
            Stein,L.
  TITLE     Alternative splicing of the Schistosoma mansoni gene encoding a
            homologue of epidermal growth factor receptor
  JOURNAL   Mol. Biochem. Parasitol. 53, 17-32 (1992)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             49..1077
                     /note="class 4 product, truncated EGF receptor"
                     /product="epidermal growth factor receptor"
                     /gene="SER"
                     /codon_start=1
                     /translation="MNFLLPTLVIIFALNCWSLKFSISEYPWIKACRVWERDCSKPNP
                     KHIQLTYIKFLYGGCTHIIGNLVICGLEKLENGSDPDLSFLEKIEDVSGYVYIGQNSV
                     KTISLPSLKVIRGEPGYRIMNTSAALVISRNSLEILDLRSLTAIQRNDIVALNNQFLC
                     NFGFTIDWEQIFEDNRKQMFIPDRKEKTVSHAGCDIALRKYTDDRTKHSCHGSCPVVN
                     GRGYCWGPKPEMCQKMLKCANNPDNYCLGGRATTQPCLEECLGGCETRPGNCRACKHA
                     MNDGKCVSQCPPPLIVSREESRTVANPEFKYNFHDICVKNCPGVKRLRKQVLIQFSIL
                     VFYSLFLH"
     sig_peptide     49..105
                     /gene="SER"
                     /codon_start=1
     mat_peptide     106..1074
                     /note="class 4 product"
                     /gene="SER"
                     /codon_start=1
     misc_feature    1004
                     /note="point of divergence from class 1 product"
                     /gene="SER"
                     /evidence=EXPERIMENTAL
     polyA_site      1339
                     /gene="SER"
                     /evidence=EXPERIMENTAL
BASE COUNT      420 a    222 c    249 g    463 t
ORIGIN
        1 tttggcacgt tttcgaaagt tgatggggtt cgacagaaca attcttaaat gaatttttta
       61 ctacctactc tggttattat tttcgctctt aattgctggt ccttaaaatt ttccatttct
      121 gagtacccat ggattaaagc ctgtcgtgtt tgggagagag actgctcgaa gcctaatcca
      181 aaacatatac agctcactta catcaagttt ttatacggag gttgtactca cataatcggg
      241 aatttggtta tatgcggtct agagaaactt gaaaatggat ccgatcctga tctttctttt
      301 cttgaaaaga ttgaagatgt gtccggttat gtgtacattg gtcaaaacag tgttaaaacg
      361 atatcattac cgtctttgaa agttattcgc ggtgaaccgg gatatcgtat catgaatact
      421 agtgctgcac ttgttattag tcgaaacagt cttgaaatcc tagatttacg aagtttgaca
      481 gccattcaac gcaacgatat tgtagcatta aataatcagt ttttgtgcaa ctttggtttc
      541 acgattgatt gggaacagat ttttgaagac aaccgtaaac aaatgtttat accggatcga
      601 aaagaaaaaa cagtttctca cgccggttgt gatattgctc tacgaaaata cactgatgat
      661 cgtaccaaac attcctgtca tggttcctgt cctgtggtaa atggacgagg ttattgctgg
      721 ggtccaaagc ctgagatgtg tcaaaaaatg ctaaaatgcg ctaacaatcc tgataactat
      781 tgtcttggtg gtagagcgac tacacaacca tgtctggaag aatgcttggg tggatgcgaa
      841 actcgtcctg gcaattgtag agcatgcaaa catgctatga atgatggcaa atgtgtatca
      901 caatgtcctc caccattgat agttagtcga gaagagagta gaactgttgc aaatccagaa
      961 ttcaaatata acttccatga catttgcgtt aaaaattgcc caggtgtaaa acgtctaaga
     1021 aaacaagtat tgatccaatt ttcaatctta gtattttatt cattatttct tcattgaatt
     1081 ccttataatt atataattat aattatgttt acactatatt ttgatacttt gtatatctaa
     1141 tcgattagtt atttccttat accctttcat taaatatcat ttgacgtata aattatgtgg
     1201 aatagtgaac caataggagt ttgaagtcct tttatcctat tagattattc actttctgtt
     1261 atttcattaa ttgttcacat gattcgcatg tatgttgtct atggaaattg atctgtgtga
     1321 atatatttat attattataa aaaaaaaaaa aaaa
//