From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: M.musculus vav mRNA
Date: 21 Jul 92 10:07:38 GMT
Distribution: bionet
Checksum: 01669     6

LOCUS       MUSVAVM      2551 bp ss-RNA             ROD       21-JUL-1992
DEFINITION  M.musculus vav mRNA
ACCESSION   X64361
KEYWORDS    GDP-GTP exchange factor; proto-oncogene; vav oncogene.
SOURCE      Mus musculus RNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Adams,J.A., Houston,H., Allen,J., Lints,T. and Harvey,R.
  TITLE     The hematopoietically expressed vav proto-oncogene shares homology
            with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene
            (CDC24) involved in cyoskeletal organisation
  JOURNAL   Oncogene 7, 611-618 (1992)
  STANDARD  full automatic
COMMENT     *source: tissue=haemopoietic; *source: clone=7OZ/3;
            Numbering is similar to that in Coppela et al (1991) cell growth
            differ., 2; 95-105
            From EMBL    entry MMVAVM;  dated 09-JUN-1992.
FEATURES             Location/Qualifiers
     CDS             14..2551
                     /function="putative GDP-GTP exchangefactor in Ras-like
                     signal transduction pathway"
                     /note="proto-oncogene"
                     /gene="vav"
                     /codon_start=1
                     /translation="MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLC
                     QLLNNLLPQAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDV
                     QDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALNDEDIYSGLSDQIDDTAEEDEDLY
                     DCVENEEAEGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQ
                     HFMKPLQRFLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKER
                     FLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL
                     KYHLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIEN
                     LDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLH
                     SFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYP
                     ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGR
                     HGQDFAGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGIPPPPGAFGPFLRLNPGDI
                     VELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGAE
                     GILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLLE
                     LVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAISKPPAGSTKYFGTAKARYDFCARDR
                     SELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC"
BASE COUNT      643 a    645 c    715 g    548 t
ORIGIN
        1 gccggcagcc accatggagc tctggcgaca gtgcacccac tggctgatcc agtgtcgggt
       61 gctgcctccc agccaccgtg tgacctggga gggggcccag gtgtgtgagc tggcacaggc
      121 actgcgggac ggtgtcctct tgtgccaatt gcttaacaac ctgcttcccc aggccattaa
      181 tcttcgcgag gttaacttgc ggccccagat gtcccagttc ctttgtctta agaacattcg
      241 aaccttcctg tctacttgct gtgagaagtt cggcctcaag cgcagtgaac tctttgaggc
      301 ttttgacctc ttcgatgtgc aggactttgg aaaggtcatc tacaccctgt ctgctctgtc
      361 atggacaccc attgcccaga acaaaggaat catgcccttc ccaacagagg acagcgctct
      421 gaacgacgaa gatatttaca gtggcctttc agaccagatt gatgacaccg cagaggaaga
      481 cgaggacctt tatgactgcg tggaaaatga ggaggcagag ggggacgaga tctacgagga
      541 cctaatgcgc ttggagtcgg tgcctacgcc acccaagatg acagagtatg ataagcgctg
      601 ctgctgcctg cgggagatcc agcagacgga ggagaagtat acagacacac tgggctccat
      661 ccagcagcac ttcatgaagc ctctgcagcg attccttaag cctcaagaca tggagaccat
      721 ctttgtcaac attgaggagc tgttctctgt gcatacccac ttcttaaagg aactgaagga
      781 tgccctggct ggcccgggag caacaacact gtatcaggtc ttcatcaagt acaaggagag
      841 gttcctggtt tatggccgtt attgcagtca ggtggagtca gccagcaagc acttggatca
      901 agtggccaca gcacgggagg atgtgcagat gaagctggag gaatgttctc aaagagctaa
      961 caatggccga ttcaccctac gggatctgct gatggtacct atgcagcggg tgctgaagta
     1021 ccacctcctt ctccaggagc tagtgaaaca cacacaggat gctacagaga aggagaacct
     1081 gcggttggcc ctggacgcca tgagggacct ggcacagtgc gtgaacgagg tcaagaggga
     1141 caatgaaacc ctacggcaga tcacaaactt tcagctgtcc attgagaacc tggaccagtc
     1201 tctggctaac tatggccggc ccaagattga cggtgagctc aagattacct cagtggagcg
     1261 tcgctcaaag acagacaggt atgccttcct gctggacaaa gcactgctca tctgtaaacg
     1321 ccgcggggac tcttacgacc tcaaagcctc ggtgaacttg cacagcttcc aagttcgaga
     1381 tgactcctcc ggggagcgag acaacaagaa gtggagccat atgttccttc tgattgagga
     1441 tcaaggcgcc cagggctatg agctgttctt caagactcgg gagctgaaga agaagtggat
     1501 ggaacagttc gaaatggcca tctccaacat ttacccagag aatgctacag ccaatgggca
     1561 tgattttcag atgttctcct ttgaggagac cacttcctgc aaggcctgcc agatgttact
     1621 cagaggcaca ttctaccagg gatatcgctg ttacaggtgc cgggcacctg cacacaagga
     1681 gtgtctgggg agagtgcctc cctgtggtcg ccatgggcaa gatttcgcag gaaccatgaa
     1741 gaaggacaag ctccatcgaa gggcccagga caagaaaagg aatgaattgg gtctgcctaa
     1801 gatggaagtg tttcaggaat actatgggat ccctcctcca cctggagcct ttgggccatt
     1861 tttacggctc aaccctgggg acattgtgga gctcactaag gcagaggctg agcacaactg
     1921 gtgggaggga aggaatactg ctacaaatga agtcggctgg tttccctgta acagagtgca
     1981 tccctatgtc cacggccctc ctcaggacct gtctgtgcat ctctggtatg cgggccctat
     2041 ggaacgagca ggcgctgagg gcatcctcac caaccgttct gatgggacct atctggtgcg
     2101 gcagagggtg aaagatacag cggagttcgc catcagcatt aagtataacg tggaggtcaa
     2161 gcatattaaa atcatgacgt cagaggggtt gtaccggatc acagagaaga aggctttccg
     2221 gggccttctg gaactggtag agttttatca gcagaattcc ctcaaagatt gcttcaagtc
     2281 gttggacacc accttgcagt ttccttataa ggaacctgag aggagagcca tcagcaagcc
     2341 accagctgga agcaccaagt attttggcac tgccaaagcc cgctacgact tctgtgcccg
     2401 ggacaggtcg gaactgtccc ttaaggaggg tgatatcatc aagatcctca ataagaaggg
     2461 acagcaaggc tggtggcgtg gggagatcta cggccggatc ggctggttcc cttctaacta
     2521 tgtggaggaa gactattccg aatattgctg a
//