From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Rattus norvegicus PIT-1-beta (PIT-1) mRNA, complete cds.
Date: 12 Sep 92 10:03:25 GMT
Distribution: bionet
Checksum: 09581     6

LOCUS       RATPIT1B     2407 bp ss-mRNA            ROD       12-SEP-1992
DEFINITION  Rattus norvegicus PIT-1-beta (PIT-1) mRNA, complete cds.
ACCESSION   L01507
KEYWORDS    DNA dependant dimerization; POU-homeodomain protein;
            nuclear protein; pituitary specific; splice variant;
            transcriptional activator.
SOURCE      Rattus norvegicus (strain Sprague-Dawley) pituitary cDNA to mRNA.
  ORGANISM  Rattus norvegicus
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Konzak,K.E. and Moore,D.D.
  TITLE     Functional isoforms of PIT-1 generated by alternative messenger RNA
            splicing
  JOURNAL   Mol. Endocrinol. 6, 241-247 (1992)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     CDS             83..1036
                     /product="PIT-1-beta"
                     /gene="PIT-1"
                     /codon_start=1
                     /translation="MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNV
                     MSTVPSILSLIQTPKCLHTYFSMTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGTLTP
                     CLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQ
                     FANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSK
                     WLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEE
                     LNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR"
     CDS             161..1036
                     /note="alternate start"
                     /product="PIT-1-beta"
                     /gene="PIT-1"
                     /codon_start=1
                     /translation="MHHSAAEGLPASNHATNVMSTVPSILSLIQTPKCLHTYFSMTTM
                     GNTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDP
                     TASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAV
                     HGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRR
                     TTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSL
                     NQSLFSISKEHLECR"
     misc_feature    225..302
                     /note="beta-specific splice sequence"
                     /gene="PIT-1"
BASE COUNT      724 a    497 c    498 g    688 t
ORIGIN
        1 cgtgaatcgg ccctttgata cagtaatata ataaaagcgg actggcaagc ggtgcgtctt
       61 agttctctac tctcttgtgg gaatgagttg ccaacctttc acctcggctg atacctttat
      121 acctctgaat tctgacgctt ctgctgccct gcctctgaga atgcaccaca gtgccgctga
      181 gggtctccca gcctccaacc acgccaccaa cgtgatgtcc acagtcccgt ctattttgtc
      241 tttgatccaa actcctaaat gtttgcacac atatttctcg atgacaacga tgggaaatac
      301 agcgacagga cttcattatt ctgtgccttc ctgtcattat ggaaaccagc catccaccta
      361 cggagtgatg gcaggcactt taaccccttg tctttacaag tttccagacc acaccctgag
      421 tcatgggttt cctcccctgc accaacctct gctggcggag gacccaacag cctctgaatt
      481 taagcaggaa ctcaggcgga aaagtaaatt ggtggaagag ccaatagaca tggactcccc
      541 ggaaatccga gaactggagc agtttgccaa cgaatttaaa gtgagaagaa ttaagttagg
      601 atacacccag acaaacgtgg gcgaagctct ggccgctgtc cacggctccg aattcagtca
      661 aacaaccatc tgccgatttg aaaacttgca gctcagtttc aaaaatgctt gcaaactgaa
      721 agcaatttta tccaagtggc tggaggaagc tgagcaggtc ggagctttgt acaatgaaaa
      781 agtgggagca aacgaaagga agaggaaacg gaggacaact atcagtatcg ccgctaagga
      841 tgctttggag agacactttg gagagcacag caaaccttct tcgcaggaga tcatgcggat
      901 ggctgaagaa ttgaatctcg agaaagaagt agtaagagtg tggttttgca accgaaggca
      961 gagagaaaaa cgggtgaaaa cgagtctcaa tcaaagtctg ttctctattt caaaggagca
     1021 tcttgagtgc agataagact tgcctgtggt agccatgtgt ggtagccttt ccattccttt
     1081 ctgatttcaa gaaaaatcag aagttactta gcttcataaa ctagattaaa tcagcaaccc
     1141 ctgcagtttt tgtttcactt tcttctttct ttccctttta gatccaatga tttaaaacaa
     1201 gacgttttat ttagttgttc tcagaattca tagcattgcc tttactccta aatcatcacc
     1261 aagaatgctc acaatacctc ttccaattct gcctttatac ctaatacaca gagaggtggg
     1321 gataactggg agagaggcca tcatatatgt gaatattttg agtttaaaat taccttttgt
     1381 aagtcaattt attgttcttt aaattttaat cagtaaggac aaatatttac cgactattaa
     1441 ccagggatgg ctcaaggttg ataatctatt gacttggcca gagagatgtc tcagtggtta
     1501 agagcatctg ttgctcttcc agaggatgtg ggttccatca cctatacagc tcacaactgt
     1561 ctgtcacact atttccagag gaaatccaag gagtctcctg ggttccattg acactcggcc
     1621 tgaaaatgag cacagacata catgtagaca aaatactcat acatatacag taaaaataat
     1681 aaatctataa acaaaaagaa aatatattgg tttatactca gtatgcccct agcactatgt
     1741 tttgttttgt tttgttttgg agtaaggttt gacaatccag aggtgactag agacaactaa
     1801 gaattttatt aattgccttc agaaataatc ttcagtcaga atctattgat atctttgaca
     1861 ttaacactta ggacacgttt tttgaacaat ttgtaggagc atttaggcat gacatctggg
     1921 cgtattcttt tatacacatt agctttctga ggctctgcta cagaaaacat gtgagctgca
     1981 agctaaactt gctgacccaa ataatccttc agttttggct ttgttttgtt ttgtttggta
     2041 gtgagttcaa tcctgagcac aagtgaaatt taaaaatgaa aaatatggtt tagggatccc
     2101 taacctatat cataaatctg tgtggaagct gcactagggc gaggctacgt ggcttacttg
     2161 ctgttatgtt tccagtgact gaaaaagcac tggctcctag taggtatgta tagaccatgc
     2221 taaaaggaat gggcccaatg gtgaacaacc gctacaaata tgaagggtac caggcaacct
     2281 gaaaaatcta acttgttttt gaagtctcat tgtagaaact cactgaggtt ccttaacaaa
     2341 gtgtcaattt tggtctcact ggtcacattt tgatttatta ataaaaattg gaaatatgaa
     2401 aaaaaaa
//