From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human mRNA for platelet derived growth factor A-chain (PDGF-A).
Date: 29 Sep 92 10:06:48 GMT
Distribution: bionet
Checksum: 17835     4

LOCUS       HUMPDGFAR    1308 bp ss-mRNA            PRI       29-SEP-1992
DEFINITION  Human mRNA for platelet derived growth factor A-chain (PDGF-A).
ACCESSION   X03795
KEYWORDS    glycoprotein; growth factor; platelet-derived growth factor;
            platelet-derived growth factor 1.
SOURCE      man (Homo sapiens).
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Betsholtz,C., Johnsson,A., Heldin,C.-H., Westermark,B., Lind,P.,
            Urdea,M.S., Eddy,R., Shows,T.B.Jr., Philpott,K., Mellor,A.L.,
            Knott,T.J. and Scott,J.
  TITLE     cDNA sequence and chromosomal localization of human
            platelet-derived growth factor A-chain and its expression in tumour
            cell lines
  JOURNAL   Nature 320, 695-699 (1986)
  STANDARD  simple automatic
COMMENT
            [1]  enum. 1 to 1308.
            EMBL features not translated to GenBank features:
               key        from     to       description
               CDS         448   1023       pro PDGF-A (aa 1-191)
               CDS         448    648       propeptide (aa 1-66)
               SITE        787    795       pot. N-linked glycosylation site
               POLYA      1308    1308      polyA signal
FEATURES             Location/Qualifiers
     CDS             388..1023
                     /product="platelet derived growth factor A chain"
                     /gene="PDGFA"
                     /codon_start=1
                     /translation="MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDL
                     QRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVI
                     YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
                     KPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT"
     sig_peptide     388..447
                     /gene="PDGFA"
                     /codon_start=1
     mat_peptide     646..1020
                     /product="platelet derived growth factor A chain"
                     /gene="PDGFA"
                     /codon_start=1
BASE COUNT      294 a    410 c    380 g    224 t
ORIGIN
        1 tccgcaaata tgcagaatta ccggccgggt cgctcctgaa gccagcgcgg ggaggcagcg
       61 cggcggcggc cagcaccggg aacgcaccga ggaagaagcc cagcccccgc cctccgcccc
      121 ttccgtcccc acccccatcc cggcggccca ggaggctccc cgcgctggcg cgcactccct
      181 gtttctcctc ctcctggctg gcgctgcctg cctctccgca ctcactgctc gccgggcgcc
      241 gtccgccagc tccgtgctcc ccgcgccacc ctcctccggg ccgcgctccc taagggatgg
      301 tactgatttt cgccgccaca ggagaccggc tggagcgccg ccccgcggcc tcgcctctcc
      361 tccgagcagc cagcgcctcg ggacgcgatg aggaccttgg cttgcctgct gctcctcggc
      421 tgcggatacc tcgcccatgt tctggccgag gaagccgaga tcccccgcga ggtgatcgag
      481 aggctggccc gcagtcagat ccacagcatc cgggacctcc agcgactcct ggagatagac
      541 tccgtaggga gtgaggattc tttggacacc agcctgagag ctcacggggt ccatgccact
      601 aagcatgtgc ccgagaagcg gcccctgccc attcggagga agagaagcat cgaggaagct
      661 gtccccgctg tctgcaagac caggacggtc atttacgaga ttcctcggag tcaggtcgac
      721 cccacgtccg ccaacttcct gatctggccc ccgtgcgtgg aggtgaaacg ctgcaccggc
      781 tgctgcaaca cgagcagtgt caagtgccag ccctcccgcg tccaccaccg cagcgtcaag
      841 gtggccaagg tggaatacgt caggaagaag ccaaaattaa aagaagtcca ggtgaggtta
      901 gaggagcatt tggagtgcgc ctgcgcgacc acaagcctga atccggatta tcgggaagag
      961 gacacgggaa ggcctaggga gtcaggtaaa aaacggaaaa gaaaaaggtt aaaacccacc
     1021 taaagcagcc aaccagatgt gaggtgagga tgagccgcag ccctttcctg ggacatggat
     1081 gtacatggcg tgttacattc ctgaacctac tatgtacggt gctttattgc cagtgtgcgg
     1141 tctttgttct cctccgtgaa aaactgtgtc cgagaacact cgggagaaca aagagacagt
     1201 gcacatttgt ttaatgtgac atcaaagcaa gtattgtagc actcggtgaa gcagtaagaa
     1261 gcttccttgt caaaaagaga gagagagaaa agaaaaaaaa aggaattc
//