From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: H.sapiens gene for IgA heavy chain.
Date: 11 Sep 92 10:04:10 GMT
Distribution: bionet
Checksum: 18306     7

LOCUS       HUMAHCNF     1520 bp ds-DNA             PRI       11-SEP-1992
DEFINITION  H.sapiens gene for IgA heavy chain.
ACCESSION   Z14985
KEYWORDS    Ig heavy chain; Ig variable region; IgA; heavy chain disease;
            immunoglobulin.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Pellet,P., Berger,R., Bernheim,A., Brouet,J.C. and Tsapis,A.
  TITLE     Molecular analysis of a t(9;14)(p11;q32) translocation occurring in
            a case of human alpha heavy chain disease
  JOURNAL   Oncogene 4, 653-657 (1989)
  STANDARD  full automatic
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Pellet,P., Tsapis,A. and Brouet,J.C.
  TITLE     Alpha heavy chain disease of patient MAL: structure of the
            non-functional rearranged alpha gene translocated on chromosome 9.
  JOURNAL   Eur. J. Immunol. 20, 2731-2735 (1990)
  STANDARD  full automatic
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Tsapis,A.
  JOURNAL   Unpublished (1992)
  STANDARD  full automatic
COMMENT     *source: tissue=Abdominal ganglion; *source: cell_type=
            B-lymphocyte; *source: is_macronuclear=N; *source: is_proviral=N;
            *source: is_germline=N;
            From EMBL    entry IGAHCNF;  dated 25-AUG-1992.
FEATURES             Location/Qualifiers
     CDS             join(32..77,162..341,435..479,806..853,1128..1178,
                     1286..1348,1286..>1348)
                     /pseudo
                     /note="nonfunctional IgA heavy chain"
                     /codon_start=1
                     /partial
     exon            32..77
                     /number=1
                     /note="start codon is GTG"
     sig_peptide     32..77
                     /note="start codon is GTG"
     intron          78..161
                     /number=1
     exon            162..341
                     /number=2
                     /note="starts VH exon homologous to VHIIfamily; contains
                     stop codons in all reading framesand misses its 3' part"
     misc_feature    342..434
                     /note="unknown origin inserted sequences"
     exon            435..479
                     /number=3
                     /note="JH4 exon"
     intron          480..513
                     /number=2
                     /note="JH4-JH5 intron missing 5'splicing consensus
                     interrupted at position 514 byan insertion"
     misc_feature    514..660
                     /note="unknown origin inserted sequences"
     intron          661..805
                     /number=3
                     /note="JH4-JH5 intron"
     exon            806..853
                     /number=4
                     /note="JH5 exon"
     intron          854..1035
                     /number=4
                     /note="JH5-pseudoJH3 intron,missing 35bp between positions
                     862 and 863"
     misc_feature    1036..1127
                     /note="unknown origin inserted sequences"
     exon            1128..1178
                     /number=5
                     /note="pseudoJH3 exon"
     intron          1179..1285
                     /number=5
                     /note="pseudoJH3-JH6 intron withdeletion of 51 bp at
                     position 1281; the deletedsequences include the
                     recombinational signals ofJH6 exon"
     exon            1286..1348
                     /number=6
                     /note="JH6 exon"
     intron          1349..1434
                     /number=6
                     /note="18 bp sequence (1416-1434) is alsopresent in the
                     14q+ derivative chromosome andresulted by duplication of
                     the germ-line sequencesflanking the chromosome breakpoint"
     misc_recomb     1434^1435
                     /organism="Homo sapiens"
                     /note="chromosomebreakpoint,sequences of chromosome band
                     14q32cease at position 1434"
     intron          1435..1520
                     /number=1
                     /note="starts sequences of chromosomeband 9p11"
                     /citation=[1]
                     /citation=[2]
                     /citation=[3]
BASE COUNT      238 a    460 c    455 g    367 t
ORIGIN
        1 tctgagagtc atggatccca tgtgcaagaa agtgcagcac ctgcggtgct tcctcctgct
       61 ggtggcggct cccagatgtg agtgtttcta ggaggcagac atggacataa gggaggctgc
      121 ctctgatccc aggtctcgct gtggattctt ctgttcacag gggtcctttg tcaagtgcgc
      181 ctgcgggagt cgggcccagg actggtcagg ccgtcgaaga ccctgcctct cccctgtgga
      241 gtctcccgtg ccttcgtcag acaccattag tcaatgtgcg cctgagtccg cctgacgcca
      301 ggtaggggac cggactggat cggcactttt ttgagggtgg ggagatttgt gagtcattgg
      361 gctttgtttc ttattcaggc cttgcgcagg tcggtcggcg cgccagcaaa tttctgtcgc
      421 cggcggccca ggggactttg acttctgggg ccagggaggc caggtccccg cctcccccgg
      481 cgagatgtca gaacgactcc cctcctttga ctcagtaaat tttcttgtcc ttttggcagg
      541 gtctcggatt ttctgccggt tgagtcccgg atgaaaacta ttcttcgtca acgatataca
      601 tccaatggcg gggcagggat tccacatgtt ccctcccctg accccgccaa ggcgtgtctc
      661 tctgtggtca ggtctaccct ctttctctgg ggtcctttgc ccgataatcc cccgggccct
      721 cacttatcag tcgcgggggg ccacagagac gtcgtggggc gccacgtcag ttctgcggtc
      781 ctccctttgg tgtcgcactc tgggcagacg tttgacccct ggggccaggg ataccaggtc
      841 accgtctcct caggcgactc gtcttacctc accgggtttc aggctccgag ccttggagac
      901 attttggacg tcaggcaaga cacctgggga cagggacccg tcgaccggga atcccagcct
      961 gtcctcccca cgtccggcca caaatgtcgg cgcctggggg gctccgtcgg ctgtggggtg
     1021 acctctttcc ggttcccctg caaagctgtc gcgaacacct ctttccggtt cccctgcaaa
     1081 gctgtcgcag acattacgtt gtgggactct gtcccgctcc aagccacctt gcagttggac
     1141 ttttgaggcc gacagtggtc tggcctctga ggagtcaggc cagactgtgg ggcacgtggg
     1201 aggccaacag cggattccat gagaggggcg gggcagggcc acggactatc accttccatg
     1261 tgacgcccgg agacagaagg catgattagg agaaccactg tgttgtggac gtctggggcc
     1321 cggggaccac ggtcaccgtc tcctcaggtg cgagtggcca ctgtagggcc tttgtgttct
     1381 gctactgcct gtgggttttc ctgagcattg caggttggtc ctcggggcct gttcagctct
     1441 gccccccagc ctctgagtac caccttatcc tagcccttag ctactggctt gtcattgtct
     1501 ctttacgttc tcagcctccc
//