From: GenBank-Updates@net.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human prostate-specific membrane antigen (APS) mRNA, complete cds.
Date: 12 Jan 93 05:46:28 GMT
Distribution: bionet
Checksum: 12278 6

LOCUS       HUMAPS       2652 bp ss-mRNA            PRI       11-JAN-1993
DEFINITION  Human prostate-specific membrane antigen (APS) mRNA, complete cds.
ACCESSION   M99487
KEYWORDS    prostate-specific membrane antigen.
SOURCE      Homo sapiens (library: LNCaP cDNA of Ron Israeli) male prostatic
            carcinoma metastatic lymph node cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2652)
  AUTHORS   Israeli,R.S., Powell,C.T., Fair,W.R. and Heston,W.D.
  TITLE     Molecular cloning of a cDNA encoding a prostate-specific membrane
            antigen
  JOURNAL   Cancer Res. (1992) In press
  STANDARD  full automatic
FEATURES             Location/Qualifiers
     CDS             262..2514
                     /gene="APS"
                     /evidence="EXPERIMENTAL"
                     /product="prostate- specific membrane antigen"
                     /codon_start=1
                     /translation="MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIK
                     SSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKE
                     FGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPP
                     FSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQ
                     LAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANE
                     YAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFT
                     GNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGA
                     AVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYI
                     NADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSG
                     MPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFY
                     DPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKT
                     YSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMCLERAFIDPLGLP
                     DRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQ
                     AAAETLSEVA"
BASE COUNT      781 a    524 c    641 g    706 t
ORIGIN      
        1 ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg
       61 attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga
      121 gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac
      181 cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag
      241 gccggctctg ctcgcgccga gatgtggaat ctccttcacg aaaccgactc ggctgtggcc
      301 accgcgcgcc gcccgcgctg gctgtgcgct ggggcgctgg tgctggcggg tggcttcttt
      361 ctcctcggct tcctcttcgg gtggtttata aaatcctcca atgaagctac taacattact
      421 ccaaagcata atatgaaagc atttttggat gaattgaaag ctgagaacat caagaagttc
      481 ttatataatt ttacacagat accacattta gcaggaacag aacaaaactt tcagcttgca
      541 aagcaaattc aatcccagtg gaaagaattt ggcctggatt ctgttgagct agcacattat
      601 gatgtcctgt tgtcctaccc aaataagact catcccaact acatctcaat aattaatgaa
      661 gatggaaatg agattttcaa cacatcatta tttgaaccac ctcctccagg atatgaaaat
      721 gtttcggata ttgtaccacc tttcagtgct ttctctcctc aaggaatgcc agagggcgat
      781 ctagtgtatg ttaactatgc acgaactgaa gacttcttta aattggaacg ggacatgaaa
      841 atcaattgct ctgggaaaat tgtaattgcc agatatggga aagttttcag aggaaataag
      901 gttaaaaatg cccagctggc aggggccaaa ggagtcattc tctactccga ccctgctgac
      961 tactttgctc ctggggtgaa gtcctatcca gatggttgga atcttcctgg aggtggtgtc
     1021 cagcgtggaa atatcctaaa tctgaatggt gcaggagacc ctctcacacc aggttaccca
     1081 gcaaatgaat atgcttatag gcgtggaatt gcagaggctg ttggtcttcc aagtattcct
     1141 gttcatccaa ttggatacta tgatgcacag aagctcctag aaaaaatggg tggctcagca
     1201 ccaccagata gcagctggag aggaagtctc aaagtgccct acaatgttgg acctggcttt
     1261 actggaaact tttctacaca aaaagtcaag atgcacatcc actctaccaa tgaagtgaca
     1321 agaatttaca atgtgatagg tactctcaga ggagcagtgg aaccagacag atatgtcatt
     1381 ctgggaggtc accgggactc atgggtgttt ggtggtattg accctcagag tggagcagct
     1441 gttgttcatg aaattgtgag gagctttgga acactgaaaa aggaagggtg gagacctaga
     1501 agaacaattt tgtttgcaag ctgggatgca gaagaatttg gtcttcttgg ttctactgag
     1561 tgggcagagg agaattcaag actccttcaa gagcgtggcg tggcttatat taatgctgac
     1621 tcatctatag aaggaaacta cactctgaga gttgattgta caccgctgat gtacagcttg
     1681 gtacacaacc taacaaaaga gctgaaaagc cctgatgaag gctttgaagg caaatctctt
     1741 tatgaaagtt ggactaaaaa aagtccttcc ccagagttca gtggcatgcc caggataagc
     1801 aaattgggat ctggaaatga ttttgaggtg ttcttccaac gacttggaat tgcttcaggc
     1861 agagcacggt atactaaaaa ttgggaaaca aacaaattca gcggctatcc actgtatcac
     1921 agtgtctatg aaacatatga gttggtggaa aagttttatg atccaatgtt taaatatcac
     1981 ctcactgtgg cccaggttcg aggagggatg gtgtttgagc tagccaattc catagtgctc
     2041 ccttttgatt gtcgagatta tgctgtagtt ttaagaaagt atgctgacaa aatctacagt
     2101 atttctatga aacatccaca ggaaatgaag acatacagtg tatcatttga ttcacttttt
     2161 tctgcagtaa agaattttac agaaattgct tccaagttca gtgagagact ccaggacttt
     2221 gacaaaagca acccaatagt attaagaatg atgaatgatc aactcatgtg tctggaaaga
     2281 gcatttattg atccattagg gttaccagac aggccttttt ataggcatgt catctatgct
     2341 ccaagcagcc acaacaagta tgcaggggag tcattcccag gaatttatga tgctctgttt
     2401 gatattgaaa gcaaagtgga cccttccaag gcctggggag aagtgaagag acagatttat
     2461 gttgcagcct tcacagtgca ggcagctgca gagactttga gtgaagtagc ctaagaggat
     2521 tctttagaga tccgtattga atttgtgtgg tatgtcactc agaaagaatc gtaatgggta
     2581 tattgataaa ttttaaaatt ggtatatttg aaataaagtt gaatattata tataaaaaaa
     2641 aaaaaaaaaa aa
//