From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human cytochrome P4502C19 (CYP2C19) mRNA, clone 11a.
Date: 5 Sep 92 10:01:20 GMT
Distribution: bionet
Checksum: 32305     5

LOCUS       HUMCYPC219   1746 bp ss-mRNA            PRI       05-SEP-1992
DEFINITION  Human cytochrome P4502C19 (CYP2C19) mRNA, clone 11a.
ACCESSION   M61854 J05326
KEYWORDS    cytochrome P-450; cytochrome P-450 2C19.
SOURCE      Human, cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Goldstein,J.A., Raucy,J.L., Blaisdell,J.A., Faletto,M.B. and
            Romkes,M.
  TITLE     Cloning and expression of complementary DNAs for multiple members
            of the human cytochrome P450IIC subfamily
  JOURNAL   Biochemistry 30, 3247-3255 (1991)
  STANDARD  simple staff_entry
FEATURES             Location/Qualifiers
     mRNA            6..1478
                     /note="/standard_name='CYP2C19'"
     CDS             6..1478
                     /product="cytochrome"
                     /codon_start=1
                     /translation="MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQ
                     IDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPL
                     AERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK
                     ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN
                     FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQ
                     NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN
                     RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLT
                     SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT
                     FILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV"
     old_sequence    replace(782,"a")
                     /citation=[1]
     old_sequence    replace(857,"g")
                     /citation=[1]
     old_sequence    replace(902..903,"gc")
                     /citation=[1]
     old_sequence    replace(1250..1251,"ac")
                     /citation=[1]
     old_sequence    replace(1601,"g")
                     /citation=[1]
                     /note="addition of t"
     old_sequence    replace(1620..1626,"aaaaaa")
                     /citation=[1]
     old_sequence    replace(1654..1657,"cccc")
                     /citation=[1]
BASE COUNT      477 a    418 c    365 g    486 t
ORIGIN
        1 cttcaatgga tccttttgtg gtccttgtgc tctgtctctc atgtttgctt ctcctttcaa
       61 tctggagaca gagctctggg agaggaaaac tccctcctgg ccccactcct ctcccagtga
      121 ttggaaatat cctacagata gatattaagg atgtcagcaa atccttaacc aatctctcaa
      181 aaatctatgg ccctgtgttc actctgtatt ttggcctgga acgcatggtg gtgctgcatg
      241 gatatgaagt ggtgaaggaa gccctgattg atcttggaga ggagttttct ggaagaggcc
      301 atttcccact ggctgaaaga gctaacagag gatttggaat cgttttcagc aatggaaaga
      361 gatggaagga gatccggcgt ttctccctca tgacgctgcg gaattttggg atggggaaga
      421 ggagcattga ggaccgtgtt caagaggaag cccgctgcct tgtggaggag ttgagaaaaa
      481 ccaaggcttc accctgtgat cccactttca tcctgggctg tgctccctgc aatgtgatct
      541 gctccattat tttccagaaa cgtttcgatt ataaagatca gcaatttctt aacttgatgg
      601 aaaaattgaa tgaaaacatc aggattgtaa gcaccccctg gatccagata tgcaataatt
      661 ttcccactat cattgattat ttcccgggaa cccataacaa attacttaaa aaccttgctt
      721 ttatggaaag tgatattttg gagaaagtaa aagaacacca agaatcgatg gacatcaaca
      781 accctcggga ctttattgat tgcttcctga tcaaaatgga gaaggaaaag caaaaccaac
      841 agtctgaatt cactattgaa aacttggtaa tcactgcagc tgacttactt ggagctggga
      901 cagagacaac aagcacaacc ctgagatatg ctctccttct cctgctgaag cacccagagg
      961 tcacagctaa agtccaggaa gagattgaac gtgtcattgg cagaaaccgg agcccctgca
     1021 tgcaggacag gggccacatg ccctacacag atgctgtggt gcacgaggtc cagagataca
     1081 tcgacctcat ccccaccagc ctgccccatg cagtgacctg tgacgttaaa ttcagaaact
     1141 acctcattcc caagggcaca accatattaa cttccctcac ttctgtgcta catgacaaca
     1201 aagaatttcc caacccagag atgtttgacc ctcgtcactt tctggatgaa ggtggaaatt
     1261 ttaagaaaag taactacttc atgcctttct cagcaggaaa acggatttgt gtgggagagg
     1321 gcctggcccg catggagctg tttttattcc tgaccttcat tttacagaac tttaacctga
     1381 aatctctgat tgacccaaag gaccttgaca caactcctgt tgtcaatgga tttgcttctg
     1441 tcccgccctt ctatcagctg tgcttcattc ctgtctgaag aagcacagat ggtctggctg
     1501 ctcctgtgct gtccctgcag ctctctttcc tctggtccaa atttcactat ctgtgatgct
     1561 tcttctgacc cgtcatctca cattttccct tcccccaaga tctagtgaac attcagcctc
     1621 cattaaaaaa gtttcactgt gcaaatatat ctgctattcc ccatactcta taatagttac
     1681 attgagtgcc acataatgct gatacttgtc taatgttgag ttattaacat attattatta
     1741 aataga
//