{"text": " 4）既往患有骨髓增生异常综合征（Myelodysplastic syndrome，MDS）的患者，或者未定型的急性白血病患者。", "label": 4, "label_text": "Disease", "id": "s1"}
{"text": " 2.严重不可控制的感染；", "label": 4, "label_text": "Disease", "id": "s2"}
{"text": " 2、自主意愿参与问卷调查", "label": 13, "label_text": "Consent", "id": "s3"}
{"text": "(1)前牙结构发育不良：釉质发育不全、氟斑牙、四环素牙等；", "label": 30, "label_text": "Oral related", "id": "s4"}
{"text": " （2）确诊存在胃肠道器质性病变者，如炎症性肠病；", "label": 4, "label_text": "Disease", "id": "s5"}
{"text": " （2）符合中医眩晕湿浊上扰证的证候诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6"}
{"text": " 6.合并有腰椎病、膝骨关节病变、足部病变等其他能够影响患者行走步态的疾病；", "label": 4, "label_text": "Disease", "id": "s7"}
{"text": " 10.怀疑或确有酒精或药物滥用史；", "label": 2, "label_text": "Addictive Behavior", "id": "s8"}
{"text": " 7）曾经或目前存在迟发性运动障碍症状的患者；", "label": 28, "label_text": "Symptom", "id": "s9"}
{"text": " g)糖尿病控制不佳（空腹血糖（FBG）＞10mmol/L）；", "label": 4, "label_text": "Disease", "id": "s10"}
{"text": " 2、腹腔内及腹膜后肿瘤性、感染性及出血性疾病；", "label": 4, "label_text": "Disease", "id": "s11"}
{"text": " 9.妊娠期、哺乳期妇女或有妊娠计划者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s12"}
{"text": " (11)受试者应有稳定可靠的照料者，或者至少能够与照料者频繁联系(每周至少照料3日，每日至少2小时)，照料者将帮助患者参与研究全过程。照料者必须陪伴受试者参加研究访视，并协助研究者完成NPI、ADCS-ADL、CIBIC-plus等量表评分；", "label": 5, "label_text": "Multiple", "id": "s13"}
{"text": " 4. 患者入选前无房颤导管消融手术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s14"}
{"text": " 8.HIV感染", "label": 4, "label_text": "Disease", "id": "s15"}
{"text": "1）男性合并男性无精症、性功能障碍、畸形精子症及免疫性不育。", "label": 4, "label_text": "Disease", "id": "s16"}
{"text": " 2、阿片类药物滥用史", "label": 2, "label_text": "Addictive Behavior", "id": "s17"}
{"text": " 7.长期使用激素和免疫抑制剂的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s18"}
{"text": "①符合的CKD及高血压的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s19"}
{"text": "（1）入院时低体温，体温<34℃", "label": 4, "label_text": "Disease", "id": "s20"}
{"text": " 4.预计生存期大于3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s21"}
{"text": "  4周内使用过长效糖皮质激素类药物者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s22"}
{"text": " (6)用药前1个月无放化疗治疗史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s23"}
{"text": " 3)接受心理治疗或其他心理干预。", "label": 0, "label_text": "Therapy or Surgery", "id": "s24"}
{"text": " 13. 肝炎筛查阳性，包括乙型肝炎表面抗原和抗丙肝病毒抗体；", "label": 12, "label_text": "Laboratory Examinations", "id": "s25"}
{"text": " 2 家长拒绝参加此项研究。", "label": 13, "label_text": "Consent", "id": "s26"}
{"text": " ⑷2周内使用可能影响HP检测结果的药物(抗酸剂、H2RA、PPI类、铋剂、抗生素等)者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s27"}
{"text": " (7) 无其他眼部疾病", "label": 4, "label_text": "Disease", "id": "s28"}
{"text": " 6.不能控制的高血压、高血糖者；", "label": 4, "label_text": "Disease", "id": "s29"}
{"text": " 4)在服用研究药物前三个月内献血或大量失血（> 450 mL）", "label": 14, "label_text": "Blood Donation", "id": "s30"}
{"text": " （4）依从性较差者如：患有精神类疾病、癫痫、癌症者。", "label": 5, "label_text": "Multiple", "id": "s31"}
{"text": "①年龄65-85岁,男女不限；", "label": 5, "label_text": "Multiple", "id": "s32"}
{"text": " 3、有上肢或者下肢神经损伤的患者", "label": 4, "label_text": "Disease", "id": "s33"}
{"text": " 3 既往有纵隔手术史或腹腔广泛黏连患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s34"}
{"text": "1. 术前胃镜病理检查证实胃癌诊断且预计行远端胃癌根治术或根治性全胃切除术", "label": 5, "label_text": "Multiple", "id": "s35"}
{"text": " 4.难以控制的重度高血压；", "label": 4, "label_text": "Disease", "id": "s36"}
{"text": "（1）年龄≥60岁；", "label": 3, "label_text": "Age", "id": "s37"}
{"text": " （7）病程为发病后2周～3个月；", "label": 4, "label_text": "Disease", "id": "s38"}
{"text": " 3. 拿到驾驶执照（C1/C2）1月内；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s39"}
{"text": " 3)能够与研究者良好交流及遵照整个试验要求", "label": 5, "label_text": "Multiple", "id": "s40"}
{"text": " （5）吸毒者或者酗酒的患者", "label": 2, "label_text": "Addictive Behavior", "id": "s41"}
{"text": " 5 伴有严重精神疾病或心理障碍、中枢神经系统紊乱、心脑血管并发症、癫痫等疾病，不能提供书面知情同意，治疗依从性差。", "label": 5, "label_text": "Multiple", "id": "s42"}
{"text": " f)研究中心或药品注册申请人工作人员或其亲属。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s43"}
{"text": " 3. 精神病患者；", "label": 4, "label_text": "Disease", "id": "s44"}
{"text": " （4）收缩压100-140mmHg；心率>60bpm；", "label": 12, "label_text": "Laboratory Examinations", "id": "s45"}
{"text": " - 婴儿出生后无免疫球蛋白接种史，14天内无疫苗接种史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s46"}
{"text": " 1.未育女性，右利手，18岁≤年龄≤30岁；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s47"}
{"text": " 7.凝血功能异常（INR＞1.5 或凝血酶原时间（PT）＞ULN+4 秒或 APTT >1.5 ULN），具有出血倾向或正在接受溶栓或抗凝治疗；", "label": 5, "label_text": "Multiple", "id": "s48"}
{"text": " 2. 病情危重需入住ICU病房的患儿；", "label": 5, "label_text": "Multiple", "id": "s49"}
{"text": " （3）DBS手术（手术靶点为双侧STN），患者术前MOCA评分>26分，术后MOCA评分20-25分", "label": 5, "label_text": "Multiple", "id": "s50"}
{"text": " 8.受试者自愿加入本研究，签署知情同意书，依从性好，配合随访。", "label": 5, "label_text": "Multiple", "id": "s51"}
{"text": " 2）性激素：青春期龈炎，妊娠期妇女", "label": 5, "label_text": "Multiple", "id": "s52"}
{"text": " 9） 酗酒者或试验前6个月内经常饮酒者，即每周饮酒超过14单位酒精（1单位=360 ml啤酒或45 ml酒精量为40 %的烈酒或150 ml葡萄酒）；", "label": 5, "label_text": "Multiple", "id": "s53"}
{"text": " 3.患者非自愿参加本项研究。", "label": 13, "label_text": "Consent", "id": "s54"}
{"text": "     A. 计划在试验后14天内完成冠脉造影检查的患者", "label": 34, "label_text": "Device", "id": "s55"}
{"text": " （5）合并肾功能不全，需要透析治疗；", "label": 5, "label_text": "Multiple", "id": "s56"}
{"text": " 9. 曾接受过用于治疗癌症的免疫细胞治疗方法，包括CIK、DC、DC-CIK、LAK细胞等；", "label": 0, "label_text": "Therapy or Surgery", "id": "s57"}
{"text": "①同一患者相同部位重复分离的菌株；", "label": 0, "label_text": "Therapy or Surgery", "id": "s58"}
{"text": " 2. 需透析治疗的终末期肾病患者；", "label": 5, "label_text": "Multiple", "id": "s59"}
{"text": " 4)试验前2周内使用过药物者，但经研究者判断已达到药物清洗时间，对试验没有干扰者除外；（问诊）", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s60"}
{"text": " （5）知情同意，志愿受试。获得知情同意书过程应符合GCP规定。", "label": 13, "label_text": "Consent", "id": "s61"}
{"text": "（1）具有乐清眼病筛查项目覆盖区域（柳市镇、乐成街道、城东街道、城南街道、盐盆街道）的户籍；", "label": 40, "label_text": "Address", "id": "s62"}
{"text": " 5.体能状态ECOG评分≤ 2.0；", "label": 9, "label_text": "Risk Assessment", "id": "s63"}
{"text": " (16).HIV、乙型肝炎表面抗原阳性、梅毒抗体阳性、丙肝抗体阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s64"}
{"text": " 3)既往曾有酒药依赖及急性中毒史的患者;", "label": 2, "label_text": "Addictive Behavior", "id": "s65"}
{"text": "1.患者病理类型为除子宫内膜样腺癌以外的特殊类型子宫内膜癌。", "label": 4, "label_text": "Disease", "id": "s66"}
{"text": " ⑷胃残留量增加（单次测量＞150ml或12小时累积量＞500ml）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s67"}
{"text": " ?乙肝表面抗原或丙肝抗体阳性，梅毒快速血浆反应素试验（(RPR))阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s68"}
{"text": " 2. 脏器功能衰竭", "label": 6, "label_text": "Organ or Tissue Status", "id": "s69"}
{"text": " 5. 全身凝血相关疾病所致子宫异常出血；", "label": 4, "label_text": "Disease", "id": "s70"}
{"text": " （6）已知对本药组分有过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s71"}
{"text": " (4)对研究药物（增强剂）无过敏，无MR检查禁忌症；", "label": 7, "label_text": "Allergy Intolerance", "id": "s72"}
{"text": " （6）对本治疗方案中不合作或不耐受者。", "label": 5, "label_text": "Multiple", "id": "s73"}
{"text": " 2）中枢神经系统感染；", "label": 4, "label_text": "Disease", "id": "s74"}
{"text": " 7.妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s75"}
{"text": " 3）近期有酗酒和镇痛药物滥用史，或强效阿片类药物和抗抑郁药物治疗史的患者。", "label": 5, "label_text": "Multiple", "id": "s76"}
{"text": " 7.肝功能Chid-Pugh A级，或Child-Pugh B级肝功能经治疗后恢复至A级；", "label": 9, "label_text": "Risk Assessment", "id": "s77"}
{"text": "1）严重上下肢活动受限者下肢关节炎患者；", "label": 4, "label_text": "Disease", "id": "s78"}
{"text": " ③发热或急性疾病期患者", "label": 4, "label_text": "Disease", "id": "s79"}
{"text": " ②年龄满18周岁及以上；", "label": 3, "label_text": "Age", "id": "s80"}
{"text": " 3）既往曾有酒药依赖及急性中毒史的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s81"}
{"text": " 9.在访视1前30天内或者5个半衰期内（以较长的时间为准）曾使用了其他试验药物；", "label": 15, "label_text": "Enrollment in other studies", "id": "s82"}
{"text": " ②正在接受或者准备接受靶向药物治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s83"}
{"text": " （4）研究者认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s84"}
{"text": " 2.维生素 D 缺乏或不足(25(OH)D < 50 nmol/l)；", "label": 12, "label_text": "Laboratory Examinations", "id": "s85"}
{"text": " 1、受试者年龄大于60岁,或小于18岁。", "label": 3, "label_text": "Age", "id": "s86"}
{"text": " 15、因居住地、工作等原因不能定期随访者。", "label": 5, "label_text": "Multiple", "id": "s87"}
{"text": "1)合并有严重心肺肝肾疾病；", "label": 4, "label_text": "Disease", "id": "s88"}
{"text": " 6.合并有活动期恶性肿瘤、脑中风、心肌梗塞等严重原发性疾病；", "label": 4, "label_text": "Disease", "id": "s89"}
{"text": " 5.拟行开腹肝切除手术治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s90"}
{"text": " 6）预计生存期≥3个月。", "label": 23, "label_text": "Life Expectancy", "id": "s91"}
{"text": " 8、激素、免疫抑制剂等药物服用史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s92"}
{"text": " 7.试验给药前3个月内参加过献血或被试验采血超过400ml者；", "label": 14, "label_text": "Blood Donation", "id": "s93"}
{"text": " [4]患者存在化疗或移植的禁忌症或拒绝行化疗及造血干细胞移植；", "label": 0, "label_text": "Therapy or Surgery", "id": "s94"}
{"text": "患者不同意或自愿退出研究；", "label": 8, "label_text": "Compliance with Protocol", "id": "s95"}
{"text": "    3）肝功能不全（ALT〉100IU/L）", "label": 5, "label_text": "Multiple", "id": "s96"}
{"text": " （6）已接受有关治疗，可能影响对有效性、安全性指标评价者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s97"}
{"text": " ⑦.同时接受其他临床试验患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s98"}
{"text": " 10)所有患者均签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s99"}
{"text": " （5）严重的失语或肢体残疾不能完成神经心理检查者；", "label": 33, "label_text": "Disabilities", "id": "s100"}
{"text": " ②有严重的肝、肾疾病者", "label": 4, "label_text": "Disease", "id": "s101"}
{"text": " 9. 育龄期妇女尿妊娠试验阴性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s102"}
{"text": " ②全身体质较差不能接受SRS", "label": 0, "label_text": "Therapy or Surgery", "id": "s103"}
{"text": " （4）ECOG体力状态0-2 ;", "label": 9, "label_text": "Risk Assessment", "id": "s104"}
{"text": " （4）严重屈曲畸形、内外翻畸形需要使用特殊假体的患者", "label": 5, "label_text": "Multiple", "id": "s105"}
{"text": " 5.已知对该类药物过敏及严重过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s106"}
{"text": " 2.必须具备黏痰症状（痰液性状评分≥2分）、咳痰困难（咳痰难度评分≥2分）等临床症状；", "label": 1, "label_text": "Sign", "id": "s107"}
{"text": " 5)有活动性的病毒或细菌感染，且未能用适当的抗感染治疗进行控制；", "label": 5, "label_text": "Multiple", "id": "s108"}
{"text": "1. 半年内新发的不稳定型心绞痛、心肌梗死、冠状动脉介入术或冠状动脉搭桥术的患者", "label": 5, "label_text": "Multiple", "id": "s109"}
{"text": " （3）恶性高热家族史", "label": 4, "label_text": "Disease", "id": "s110"}
{"text": " 4 不能完成问卷调查。", "label": 17, "label_text": "Capacity", "id": "s111"}
{"text": "（1）曾因失眠接受针刺治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s112"}
{"text": " 2.拒绝加入此项研究者", "label": 13, "label_text": "Consent", "id": "s113"}
{"text": " （3）拒绝签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s114"}
{"text": " ⑨能够配合研究者完成检查，并自愿签署本研究知情同意书者。", "label": 13, "label_text": "Consent", "id": "s115"}
{"text": " 4.影像学显示肿瘤已侵犯重要血管或经研究者判断患者肿瘤在治疗期间有极高可能侵袭重要血管而引起致命大出血的情况；", "label": 5, "label_text": "Multiple", "id": "s116"}
{"text": " 15、有其他合并用的抗癌治疗（包括LHRH激动剂、抗癌中药、免疫治疗），类固醇激素除外；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s117"}
{"text": " 10. 存在影响认知能力的神经或精神异常，包括中枢神经系统的转移；", "label": 4, "label_text": "Disease", "id": "s118"}
{"text": "①年龄16～35岁；", "label": 3, "label_text": "Age", "id": "s119"}
{"text": "（1） BMI> 38 kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s120"}
{"text": " 5)预计生存期超过3月。", "label": 23, "label_text": "Life Expectancy", "id": "s121"}
{"text": " （3）既往有腹腔手术史或腹腔广泛黏连患者；", "label": 5, "label_text": "Multiple", "id": "s122"}
{"text": " 3.轻度认知功能障碍：符合Peterson诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s123"}
{"text": " 6.受试者无生育能力，或同意在研究过程中采用避孕措施", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s124"}
{"text": " 2)血常规WBC低于4×109/L或大于11×109/L和/或中性粒细胞分类N%≥80%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s125"}
{"text": "1. MR明确诊断ChiariⅠ畸形，具有相应临床症状体征；", "label": 5, "label_text": "Multiple", "id": "s126"}
{"text": " 5)由研究者判断的反复发作的主要低血糖事件。", "label": 21, "label_text": "Researcher Decision", "id": "s127"}
{"text": " 4.既往或目前患有任何严重或不稳定躯体疾病；", "label": 4, "label_text": "Disease", "id": "s128"}
{"text": " 2.年龄≤40岁；", "label": 3, "label_text": "Age", "id": "s129"}
{"text": " 10.有孤独肾或输尿管及尿路狭窄等先天性异常。", "label": 4, "label_text": "Disease", "id": "s130"}
{"text": " 4、严重影响药物吸收的胃肠病患者", "label": 4, "label_text": "Disease", "id": "s131"}
{"text": " (11) 近三月内参加其他药物临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s132"}
{"text": " （6）试验开始前3个月内未经过任何牙周治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s133"}
{"text": " 3.HIV阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s134"}
{"text": "1.有未被控制的全身疾病或活动性非青光眼性眼病患者；", "label": 4, "label_text": "Disease", "id": "s135"}
{"text": " 4、服用可影响认知功能的药物者（如毒麻药、镇静剂等）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s136"}
{"text": "① 拒绝参加本研究；", "label": 13, "label_text": "Consent", "id": "s137"}
{"text": " （4）拒绝签署知情同意书参加试验者。", "label": 13, "label_text": "Consent", "id": "s138"}
{"text": "1) 获得患者书面知情同意；", "label": 13, "label_text": "Consent", "id": "s139"}
{"text": " ⑵怀孕或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s140"}
{"text": " 3)受者原发病确诊为局灶性节段性肾小球硬化症(FSGS)或膜性增生性肾小球肾炎(MPGN)；", "label": 4, "label_text": "Disease", "id": "s141"}
{"text": "(1)符合2010年改版的McDonald MS诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s142"}
{"text": " 心动过缓", "label": 4, "label_text": "Disease", "id": "s143"}
{"text": " 12) 孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s144"}
{"text": " 18从筛选阶段至研究用药前发生急性疾病或有合并用药；", "label": 5, "label_text": "Multiple", "id": "s145"}
{"text": " 2.并发重大的医疗疾病；", "label": 4, "label_text": "Disease", "id": "s146"}
{"text": " （2）既往进行过胸腔局部给药治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s147"}
{"text": " （21）对受试药成份（包括赋形剂）过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s148"}
{"text": " ③ 合并严重心、脑、肝、肾疾病及精神病患者，ECOG评分＞2分", "label": 5, "label_text": "Multiple", "id": "s149"}
{"text": " 2）肿瘤位于右半结肠：回盲部、升结肠、结肠肝曲、横结肠右1/3；", "label": 24, "label_text": "Neoplasm Status", "id": "s150"}
{"text": " （3）入组前全身情况或肝脏功能允许实施肝切除术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s151"}
{"text": " 5、 爱丁堡利手量表评定为右利手；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s152"}
{"text": " 11.患有全身性感染或皮肤感染；", "label": 4, "label_text": "Disease", "id": "s153"}
{"text": " 4)患者或家属签署临床用药知情同意书；", "label": 13, "label_text": "Consent", "id": "s154"}
{"text": " （5）骨盆、下肢无骨折,生命体征平稳、心肺功能良好；无严重并发症，如心肺疾病，颅脑损伤等，病情稳定；", "label": 4, "label_text": "Disease", "id": "s155"}
{"text": " （7) 入组时间距手术和末次化疗结束时间为14-28天（以完成上述两种治疗方案最后结束的时间作为起点计算）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s156"}
{"text": " 2. 年龄18～70岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s157"}
{"text": " 2.肺炎性结节与肺肿瘤鉴别困难者 ；", "label": 4, "label_text": "Disease", "id": "s158"}
{"text": " ⑤ 预期生存期≥3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s159"}
{"text": " 2.目前正接受音樂治療者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s160"}
{"text": " 2 女性.", "label": 35, "label_text": "Gender", "id": "s161"}
{"text": " 3.既往有严重神经、精神疾病史者。", "label": 4, "label_text": "Disease", "id": "s162"}
{"text": "1)眼部烧伤或严重角膜瘢痕的患者", "label": 4, "label_text": "Disease", "id": "s163"}
{"text": " 4.VAS评分>50", "label": 9, "label_text": "Risk Assessment", "id": "s164"}
{"text": " 3. 患者手术前一月内有影响涎腺功能的疾病史和用药史。", "label": 5, "label_text": "Multiple", "id": "s165"}
{"text": " 13.患有周围神经系统疾病，四肢肌力在3级及以上者。", "label": 5, "label_text": "Multiple", "id": "s166"}
{"text": " 7.重度肝功能不全（Child-Pugh评分≥10分）；", "label": 5, "label_text": "Multiple", "id": "s167"}
{"text": " 5体表皮肤破损、溃烂或皮肤病患者。", "label": 4, "label_text": "Disease", "id": "s168"}
{"text": "1、年龄大于18 岁；", "label": 3, "label_text": "Age", "id": "s169"}
{"text": " （2）符合四版中国临床皮肤性病学提出诊断依据(临床表现、最小红斑量的检查，光激发试验，组织病理学）。", "label": 11, "label_text": "Diagnostic", "id": "s170"}
{"text": "1.年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s171"}
{"text": " 5. 参加其它临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s172"}
{"text": " 10) 对饮食有特殊要求，不能遵守统一饮食者；", "label": 18, "label_text": "Diet", "id": "s173"}
{"text": " 8.长期未治愈的伤口或骨折；", "label": 4, "label_text": "Disease", "id": "s174"}
{"text": " 3.签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s175"}
{"text": " 15.身体或心理因素影响，导致口腔环境较差，不能保持良好的口腔卫生护理；", "label": 30, "label_text": "Oral related", "id": "s176"}
{"text": "A：（1）对受试药物耐受的健康人；（2）年龄：0-18岁；（3）自愿参加本研究", "label": 5, "label_text": "Multiple", "id": "s177"}
{"text": " 5) 术眼外伤性白内障或先天性双侧白内障患者；", "label": 4, "label_text": "Disease", "id": "s178"}
{"text": " 用药或上述药物剂量改变者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s179"}
{"text": " 3、肿瘤，心肺、肝、肾功能不全", "label": 5, "label_text": "Multiple", "id": "s180"}
{"text": "（1） 患者年龄在18-70 岁之间；", "label": 3, "label_text": "Age", "id": "s181"}
{"text": " 5. 研究者认为有其它疾病需要排除此研究。", "label": 21, "label_text": "Researcher Decision", "id": "s182"}
{"text": " 2.包括创伤性肘关节功能障碍、先天性畸形肘关节功能障碍、脑外伤后异位骨化所致的肘关节功能障碍、烧伤后异位骨化所致的肘关节功能障碍、风湿免疫性疾病所致的肘关节功能障碍、退行性关节炎所致肘关节功能障碍，以及各类关节内感染所致的肘关节功能障碍患者；", "label": 4, "label_text": "Disease", "id": "s183"}
{"text": " 6）受者接受多米诺肝移植、边缘供肝等有缺陷的供体；", "label": 0, "label_text": "Therapy or Surgery", "id": "s184"}
{"text": " （6）妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s185"}
{"text": " 2.符合中医痰瘀互结证辨证标准者；", "label": 11, "label_text": "Diagnostic", "id": "s186"}
{"text": " （2）自愿作为受试对象，签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s187"}
{"text": " ②接受家庭透析的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s188"}
{"text": " 5）近 3 月内接受电休克治疗者（ECT）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s189"}
{"text": "1. 年龄18-60周岁患者；", "label": 3, "label_text": "Age", "id": "s190"}
{"text": " ③患有抑郁，老年抑郁量表（GDS）≥11分或其它精神病史（如人格障碍、精神分裂症等）；", "label": 5, "label_text": "Multiple", "id": "s191"}
{"text": " 2. 组织病理学对原发病灶和区域淋巴结进行活检，确诊为原发浸润性乳腺腺癌，腹部B超、胸部CT和全身骨扫描除外远处转移，临床分期ⅡA~ⅢB期（T2-3N0-2M0），可以进行手术治疗；", "label": 5, "label_text": "Multiple", "id": "s192"}
{"text": " 3.无自主行动能力的患者;", "label": 17, "label_text": "Capacity", "id": "s193"}
{"text": "（1）临床考虑为急性缺血性脑卒中，并引起神经功能缺损。", "label": 4, "label_text": "Disease", "id": "s194"}
{"text": "1.妊娠早期≤12周", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s195"}
{"text": " 7.肿瘤浸润胸壁、皮肤，炎性乳腺癌", "label": 4, "label_text": "Disease", "id": "s196"}
{"text": " 2、 经医生诊断为痛风，入选前三个月未使用降尿酸药物；", "label": 5, "label_text": "Multiple", "id": "s197"}
{"text": " 6) CMVIgG阴性的受者，接受CMV IgG阳性的供肾（CMV IgG （D+/R-)）", "label": 12, "label_text": "Laboratory Examinations", "id": "s198"}
{"text": " 4）年龄为18～45岁男性受试者（包括18岁和45岁）；", "label": 5, "label_text": "Multiple", "id": "s199"}
{"text": " （3）年龄18～75岁；", "label": 3, "label_text": "Age", "id": "s200"}
{"text": "   ③考虑可手术切除(根治或姑息切除)；", "label": 0, "label_text": "Therapy or Surgery", "id": "s201"}
{"text": " （7）正在参加其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s202"}
{"text": " a.TBIL<1.5ULN；", "label": 12, "label_text": "Laboratory Examinations", "id": "s203"}
{"text": " ?3.曾经或同时患其他恶性肿瘤", "label": 4, "label_text": "Disease", "id": "s204"}
{"text": " 3)Tamai分区III-V区者", "label": 4, "label_text": "Disease", "id": "s205"}
{"text": "1、急性脑梗死患者，年龄≥18岁，CTA或MRA证明大血管闭塞患者。", "label": 5, "label_text": "Multiple", "id": "s206"}
{"text": " 5、 发病前有其他原因所致运动功能障碍。", "label": 4, "label_text": "Disease", "id": "s207"}
{"text": " 4、理解并自愿签署书面知情同意书，愿意并且能够遵守所有的试验要求。", "label": 13, "label_text": "Consent", "id": "s208"}
{"text": " 2、DSA造影提示双侧颈动脉系统同时急性闭塞；", "label": 11, "label_text": "Diagnostic", "id": "s209"}
{"text": " ②经血液专科医师评估后有显著肝肾功能损害等化疗禁忌症且上述禁忌症经积极治疗后仍无法消除可耐受化疗者；", "label": 5, "label_text": "Multiple", "id": "s210"}
{"text": " ⑥不愿加入本试验者；", "label": 13, "label_text": "Consent", "id": "s211"}
{"text": " (7)入组前1周之内血常规检查基本正常（以各研究中心化验室的正常值为标准）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s212"}
{"text": " （5）过去未服用降压药物者或者已服用一种西药降压药物至少14天(只能是钙离子拮抗剂、血管紧张素转化酶抑制剂、血管紧张素II受体拮抗剂）但血压仍未达标者；", "label": 5, "label_text": "Multiple", "id": "s213"}
{"text": " 9)遗传学或获得性出血体质，抗凝因子缺乏；或已口服抗凝药且INR>1.7；", "label": 5, "label_text": "Multiple", "id": "s214"}
{"text": " 5)严重或难以控制的感染；", "label": 4, "label_text": "Disease", "id": "s215"}
{"text": " ⑦ 妊娠（经尿/血检确认）、哺乳女性或有生育能力但未用避孕措施的；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s216"}
{"text": " ④BMI＞30kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s217"}
{"text": " (2)年龄≥60岁", "label": 3, "label_text": "Age", "id": "s218"}
{"text": "1. 年龄18-75岁；", "label": 3, "label_text": "Age", "id": "s219"}
{"text": " 5.有重大疾病既往史（肝炎、肾炎、心肌炎等）；", "label": 4, "label_text": "Disease", "id": "s220"}
{"text": " c） 有牙齿过敏史。", "label": 7, "label_text": "Allergy Intolerance", "id": "s221"}
{"text": " (8)伴有焦虑、抑郁、痴呆等。", "label": 28, "label_text": "Symptom", "id": "s222"}
{"text": "1) 手足多汗症患者以及术前汗症患者；", "label": 4, "label_text": "Disease", "id": "s223"}
{"text": " b）患者自愿参加此试验并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s224"}
{"text": " 3. 具有胆道恶性肿瘤以外的其他恶性肿瘤史 （业已治愈的宫颈原位癌或皮肤基底细胞癌以及已治愈 5 年的其他恶性肿瘤除外） ；", "label": 4, "label_text": "Disease", "id": "s225"}
{"text": " ④．妊娠期受试者、危重病受试者及有其他手术禁忌的病例。如有严重的心脏血管疾患，凝血功能明显异常，非移行上皮肿瘤（如腺癌、鳞癌），急性膀胱炎，脊柱畸形不能平卧者，尿道狭窄未治者等。", "label": 5, "label_text": "Multiple", "id": "s226"}
{"text": " 5.预计生存时间≥3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s227"}
{"text": " 3.自愿参加临床研究，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s228"}
{"text": " 6). 不伴随化疗组体力状况ECOG评分0-3分；伴随化疗组体力状况ECOG评分0-2分；", "label": 9, "label_text": "Risk Assessment", "id": "s229"}
{"text": " 11)怀孕期或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s230"}
{"text": " 2)睡眠自评量表（SRSS）≧20分的患者。", "label": 9, "label_text": "Risk Assessment", "id": "s231"}
{"text": " （2） 因肾病综合征、甲状腺机能减退、痛风、急性或慢性肝胆疾病、糖尿病等所致的高脂血症；", "label": 4, "label_text": "Disease", "id": "s232"}
{"text": " （5）有呼吸道慢性病史，不能耐受艾灸气味者。", "label": 5, "label_text": "Multiple", "id": "s233"}
{"text": " 10.筛选时血清肌酐大于正常值上限1.5倍；", "label": 12, "label_text": "Laboratory Examinations", "id": "s234"}
{"text": " 4) 妊娠或者哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s235"}
{"text": " (4)预估ICU住院时间≥48h。", "label": 26, "label_text": "Encounter", "id": "s236"}
{"text": "1. 存在摄食困难症状；", "label": 1, "label_text": "Sign", "id": "s237"}
{"text": " （4）局部接受过放射治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s238"}
{"text": "1）成都地区社区居民，年龄65～80岁；", "label": 5, "label_text": "Multiple", "id": "s239"}
{"text": " ② 伴高雄的瘦型PCOS的辩证分型：", "label": 11, "label_text": "Diagnostic", "id": "s240"}
{"text": "1.经细胞学或组织病理学诊断为非小细胞肺癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s241"}
{"text": " 7.此次手术伴有胸膜切除者", "label": 0, "label_text": "Therapy or Surgery", "id": "s242"}
{"text": "⑴已存在的疾病会影响到创面愈合（如恶性肿瘤、自身免疫病）；", "label": 4, "label_text": "Disease", "id": "s243"}
{"text": " 7. 签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s244"}
{"text": " （2）均为原发性高血压患者，高血压1-2级；", "label": 4, "label_text": "Disease", "id": "s245"}
{"text": " （3）排除外科手术或6个月内来行任何微创治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s246"}
{"text": " 8)有明确的神经或精神障碍史（包括癫痫和痴呆）者。", "label": 4, "label_text": "Disease", "id": "s247"}
{"text": " BIL <1.5倍正常值上限（ULN）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s248"}
{"text": " （2）患有自身免疫疾病、肝病、肾病、冠心病、甲状腺疾病、下丘脑垂体疾病、肾上腺疾病、新发脑血管疾病、严重高血压", "label": 4, "label_text": "Disease", "id": "s249"}
{"text": " 2. 曾使用过多柔比星总累积剂量≥300mg/m2或表柔比星总累积剂量≥450mg/ m2，或既往应用蒽环类药物引起心脏病变受试者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s250"}
{"text": " 3、服用止痛药及精神类药物者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s251"}
{"text": " 4、胸部X线排除合并肺炎；", "label": 11, "label_text": "Diagnostic", "id": "s252"}
{"text": "1. 下肢动脉有置入支架史或人工血管移植史。", "label": 34, "label_text": "Device", "id": "s253"}
{"text": " （3）与有症状的的颅内狭窄同侧的颅外段颈动脉狭窄（＞50%）；", "label": 4, "label_text": "Disease", "id": "s254"}
{"text": " b)牙槽骨吸收≥30%", "label": 12, "label_text": "Laboratory Examinations", "id": "s255"}
{"text": " (6)研究者认为不适合参加试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s256"}
{"text": " ⑶年龄在18～65岁之间，男女不限；", "label": 5, "label_text": "Multiple", "id": "s257"}
{"text": " 4、充分理解该研究并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s258"}
{"text": " 12.对受试样品过敏或出现明显消化道症状如不能耐受者，", "label": 7, "label_text": "Allergy Intolerance", "id": "s259"}
{"text": " (6)文化水平：小学三年级及以上。", "label": 41, "label_text": "Education", "id": "s260"}
{"text": " （6）性生活正常且规律。", "label": 37, "label_text": "Sexual related", "id": "s261"}
{"text": " （2）有严重心理或精神疾病的患者；", "label": 4, "label_text": "Disease", "id": "s262"}
{"text": "1, 继发于房间隔缺损，或室间隔缺损，或动脉导管未闭的肺动脉高压；", "label": 4, "label_text": "Disease", "id": "s263"}
{"text": "1.病理学证实为鼻咽癌；", "label": 11, "label_text": "Diagnostic", "id": "s264"}
{"text": " 4.同一团队治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s265"}
{"text": " 3．择期拟行全身麻醉下双腔支气管导管插管，进行肺部切除术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s266"}
{"text": " ⑵符合膝关节骨关节炎（OA）诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s267"}
{"text": " 3.中毒后有意识障碍的患者", "label": 4, "label_text": "Disease", "id": "s268"}
{"text": " 7.在参加本研究前的3个月内接受过实质性脏器手术的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s269"}
{"text": " 2,椎基底动脉系统脑梗死；", "label": 4, "label_text": "Disease", "id": "s270"}
{"text": " 2)闭合性骨折；", "label": 4, "label_text": "Disease", "id": "s271"}
{"text": " 2.体检排除功能性胃肠疾病及其他器质性疾病；", "label": 4, "label_text": "Disease", "id": "s272"}
{"text": " （3）入组前带瘤生存超过5年，用以排除浅表性鳞状细胞癌等其他较为罕见ICC病理类型；", "label": 5, "label_text": "Multiple", "id": "s273"}
{"text": " （5）术后预期存活时间<24h者。", "label": 23, "label_text": "Life Expectancy", "id": "s274"}
{"text": "（1）已证实对盐酸安罗替尼胶囊和/或其辅料过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s275"}
{"text": "1. 单纯因诊断性检查或血液透析而入院的患者。", "label": 5, "label_text": "Multiple", "id": "s276"}
{"text": "1.ASA I-II级；", "label": 9, "label_text": "Risk Assessment", "id": "s277"}
{"text": " 4)严重的肺功能不全伴呼吸困难，不能平卧者；", "label": 5, "label_text": "Multiple", "id": "s278"}
{"text": "1、既往有心脏手术史及脑血管病史", "label": 5, "label_text": "Multiple", "id": "s279"}
{"text": " 5.无明显手术禁忌症；", "label": 4, "label_text": "Disease", "id": "s280"}
{"text": " 6）具有良好的自知力，能理解疾病并主动接受治疗。", "label": 17, "label_text": "Capacity", "id": "s281"}
{"text": " （2）体温≥38°C；", "label": 12, "label_text": "Laboratory Examinations", "id": "s282"}
{"text": " 2.身体健康；", "label": 32, "label_text": "Healthy", "id": "s283"}
{"text": "(1)过敏体质，如对两种或以上药物、食物和花粉过敏者，或已知对本药组分或类似物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s284"}
{"text": " (3)严重的糖尿病、肝病和凝血功能异常者等有手术禁忌证者；", "label": 5, "label_text": "Multiple", "id": "s285"}
{"text": "  1周内使用过H1抗组胺药物、丙咪嗪、吩噻嗪、β肾上腺素等药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s286"}
{"text": " (5)根据病史、体格检查和实验室检查结果，研究者认为受试者健康状态良好。", "label": 5, "label_text": "Multiple", "id": "s287"}
{"text": " 6）具备单采或者静脉采血足够的静脉通路，并且没有其他的血细胞分离禁忌症；", "label": 5, "label_text": "Multiple", "id": "s288"}
{"text": " 5、各器官功能基本正常（在无持续支持治疗的情况下，入组前1周之内的实验室检查结果）；中性粒细胞＞1.5×109/L，血小板＞100×109/L，血红蛋白＞9.0g/dl；胆红素正常或＜1.5×ULN；AST(SGOT)、ALT(SGPT)＜2.5×ULN（如果肝转移则＜5× ULN）；血清肌酐＜1.5× ULN；", "label": 5, "label_text": "Multiple", "id": "s289"}
{"text": " 2)凝血功能较差，出血倾向明显，不能进行内镜切除息肉手术者。", "label": 5, "label_text": "Multiple", "id": "s290"}
{"text": " 7.不愿或不能停止使用已知会导致干眼症的药物（如异维A酸和抗组胺药）。受试者不愿在基线检查前至少一个月停止这些药物；", "label": 17, "label_text": "Capacity", "id": "s291"}
{"text": " ②本次妊娠孕龄≤8周，且超声表现为孕囊型CSP患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s292"}
{"text": " ⑦明显的神经、精神病史，包括可能影响理解能力和知情同意的痴呆。", "label": 4, "label_text": "Disease", "id": "s293"}
{"text": " 8) 各种血液系统疾病如白血病、淋巴瘤、 再生障碍性贫血、 MDS、", "label": 4, "label_text": "Disease", "id": "s294"}
{"text": "1. 怀孕或哺乳期妇女；育龄妇女未避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s295"}
{"text": " （4）肿瘤局限在右半肝,符合右半肝切除或扩大右半肝切除可以达到根治效果；", "label": 5, "label_text": "Multiple", "id": "s296"}
{"text": " ⑤.精神病患者；", "label": 4, "label_text": "Disease", "id": "s297"}
{"text": " 2 知情同意并签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s298"}
{"text": " 4. ECOG评分0-2分；", "label": 9, "label_text": "Risk Assessment", "id": "s299"}
{"text": " 3. 符合中医气阴两虚兼热证者；", "label": 11, "label_text": "Diagnostic", "id": "s300"}
{"text": " 7.髋关节或身体其他部位存在活动性感染病灶者；", "label": 4, "label_text": "Disease", "id": "s301"}
{"text": " ⑹知情同意，志愿受试。", "label": 13, "label_text": "Consent", "id": "s302"}
{"text": " e) ECOG评分≤2分，预计生存期大于3个月；", "label": 5, "label_text": "Multiple", "id": "s303"}
{"text": " （2）既往曾行TEVAR术或者开胸心脏手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s304"}
{"text": " 15) 葡萄糖糖耐量试验OGTT，诊断为糖耐量受损者。", "label": 11, "label_text": "Diagnostic", "id": "s305"}
{"text": " ⑤ 初次诊断的哮喘患者或者既往有哮喘病史", "label": 4, "label_text": "Disease", "id": "s306"}
{"text": " （6）患者必须稳定应用最小推荐剂量ACEI或ARB治疗3个月以上（ACEI和ARB不可联用），且在筛选前4周未调整该治疗方案；", "label": 0, "label_text": "Therapy or Surgery", "id": "s307"}
{"text": " 3 患有甲状腺疾病；", "label": 4, "label_text": "Disease", "id": "s308"}
{"text": " 4）受试者存在体外冲击波治疗的禁忌症；", "label": 4, "label_text": "Disease", "id": "s309"}
{"text": " 5.在过去1 年中，颈肩痛时间至少有30 天；", "label": 28, "label_text": "Symptom", "id": "s310"}
{"text": " GCS评分15；", "label": 9, "label_text": "Risk Assessment", "id": "s311"}
{"text": " 11). 已知对试验用药物及其辅料过敏或不能耐受的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s312"}
{"text": " 6) 有急性或严重全身感染者；", "label": 4, "label_text": "Disease", "id": "s313"}
{"text": " （5）近1个月内未接受过影响本试验观察的药物治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s314"}
{"text": " 3.年龄60~85岁；", "label": 3, "label_text": "Age", "id": "s315"}
{"text": " (2)糖尿病合并妊娠者；", "label": 4, "label_text": "Disease", "id": "s316"}
{"text": "     ii. eGFR <60 mL/min/1.73m2 ≥3个月，有或无肾脏损伤证据；", "label": 5, "label_text": "Multiple", "id": "s317"}
{"text": " 4).糖化血红蛋白≤8%；未发生酮症；", "label": 12, "label_text": "Laboratory Examinations", "id": "s318"}
{"text": " 5)根据研究者判断，患者有任何不适合参加本研究的或可能使患者不能可靠地参加本研究全过程的任何疾病。", "label": 21, "label_text": "Researcher Decision", "id": "s319"}
{"text": " ③椎动脉合并基底动脉狭窄", "label": 4, "label_text": "Disease", "id": "s320"}
{"text": " 16.无法去除感染源，如无法外科干预或引流。", "label": 5, "label_text": "Multiple", "id": "s321"}
{"text": " 3）对方案涉及到的任何一个药物存在过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s322"}
{"text": " （3）正畸治疗前牙面已经存在釉质发育不全、氟斑、釉质脱矿等情况。", "label": 30, "label_text": "Oral related", "id": "s323"}
{"text": "(1)符合2-3级肝硬化腹水的西医诊断；", "label": 11, "label_text": "Diagnostic", "id": "s324"}
{"text": " 2椎-基底动脉系统脑梗死、多发性腔隙性脑梗死病史和或重度脑白质疏松(能够通过CT进行判断)；", "label": 11, "label_text": "Diagnostic", "id": "s325"}
{"text": "1.孕妇及母乳喂养的产妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s326"}
{"text": "1．妊娠、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s327"}
{"text": " （4）外周血白细胞≥3.5x10 9 ,血小板及肝肾功能正常。", "label": 5, "label_text": "Multiple", "id": "s328"}
{"text": "（1）年龄16~70岁的男性或女性患者", "label": 5, "label_text": "Multiple", "id": "s329"}
{"text": " （14）近3月内曾参加其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s330"}
{"text": " 2、相关检查资料不完善者；", "label": 22, "label_text": "Data Accessible", "id": "s331"}
{"text": " 8. 多种并发症，如肝性脑病、消化道出血、脾功能明显亢进。", "label": 4, "label_text": "Disease", "id": "s332"}
{"text": " 3.年龄5～14岁。", "label": 3, "label_text": "Age", "id": "s333"}
{"text": "1.原发孔型ASD及静脉窦型ASD。", "label": 4, "label_text": "Disease", "id": "s334"}
{"text": " 3 入组时年龄为0-12月龄*；", "label": 3, "label_text": "Age", "id": "s335"}
{"text": " 4.圆形、类圆形（形状不规则但类似圆形）、椭圆形 (长径：短径≤2：1) 动脉瘤，包括有子囊的动脉瘤；", "label": 4, "label_text": "Disease", "id": "s336"}
{"text": "1、 确诊时或目前符合RA诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s337"}
{"text": " *诊断为原发性或继发性NS，Ccr>80ml/min;", "label": 4, "label_text": "Disease", "id": "s338"}
{"text": " ⑤术前认知发育筛查（DST）发现发育迟缓；", "label": 11, "label_text": "Diagnostic", "id": "s339"}
{"text": " 5、近四周内参加过其它研究药物的临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s340"}
{"text": " 5. 每支血管只有一个分叉病变", "label": 4, "label_text": "Disease", "id": "s341"}
{"text": " C.病人签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s342"}
{"text": "1)纠正胎龄不足43周；", "label": 3, "label_text": "Age", "id": "s343"}
{"text": " 5）术前1年内使用连续激素大于5天；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s344"}
{"text": " (6)预计依从性差，不能定期访视，或不能按照要求填写患者日记卡者；", "label": 5, "label_text": "Multiple", "id": "s345"}
{"text": " （4） 曾使用TNF-α抑制剂等生物制品治疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s346"}
{"text": " 8、孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s347"}
{"text": " 8) 无远处转移证据；", "label": 24, "label_text": "Neoplasm Status", "id": "s348"}
{"text": "1)不能看或者听微信平台上发送内容，如视频，文章，海报等", "label": 25, "label_text": "Literacy", "id": "s349"}
{"text": " 2）严重慢性并发症；肿瘤病史；其他内分泌疾病；消化吸收功能障碍；", "label": 4, "label_text": "Disease", "id": "s350"}
{"text": " 2)Platelets ≥ 100 x109/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s351"}
{"text": " (2) 即将开始第一次化疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s352"}
{"text": " 4）根据医生判断，容易造成失访者。", "label": 21, "label_text": "Researcher Decision", "id": "s353"}
{"text": "1）合并严重的内科疾病，包括脑血管病、肾功能衰竭、未控制的糖尿病、未控制的高血压和肺部疾病、严重感染、活动性消化性溃疡及可能干扰药物治疗的其他合并症。", "label": 5, "label_text": "Multiple", "id": "s354"}
{"text": " （二）维持治疗阶段：", "label": 0, "label_text": "Therapy or Surgery", "id": "s355"}
{"text": " 2）初诊的JIA患儿", "label": 4, "label_text": "Disease", "id": "s356"}
{"text": " ⑤使用长效抗精神病药针剂，或入组前1周使用过其它抗精神病药、心境稳定剂者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s357"}
{"text": "1) 拟在体外循环下行瓣膜置换术的换择期手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s358"}
{"text": "1、前列腺穿刺活检明确诊断的前列腺癌患者。", "label": 11, "label_text": "Diagnostic", "id": "s359"}
{"text": " ⑶ 有自身免疫性肝炎征象者（抗核抗体滴度＞1:100）。", "label": 5, "label_text": "Multiple", "id": "s360"}
{"text": "1)试验前签署知情同意书、并对试验内容、过程及可能出现的不良反应充分了解；", "label": 13, "label_text": "Consent", "id": "s361"}
{"text": " 6、18～60岁；", "label": 3, "label_text": "Age", "id": "s362"}
{"text": " 5.入组4周内接受过重大外科手术或出现重度创伤性损伤、骨折或溃疡；", "label": 5, "label_text": "Multiple", "id": "s363"}
{"text": " （4）自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s364"}
{"text": " 9）再次腹部手术并肠粘连严重者。", "label": 5, "label_text": "Multiple", "id": "s365"}
{"text": " 2)妊娠、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s366"}
{"text": " （10）伴有其它严重活动性感染者；", "label": 4, "label_text": "Disease", "id": "s367"}
{"text": " 2. 继发青光眼或眼压连续两次测量超过30mmHg；", "label": 5, "label_text": "Multiple", "id": "s368"}
{"text": " 3. 在<40岁患者有诊断哮喘的病史。但是在≥40岁患者有诊断哮喘病史的可以入选试验；", "label": 5, "label_text": "Multiple", "id": "s369"}
{"text": " 4）患者预期寿命少于一年；", "label": 23, "label_text": "Life Expectancy", "id": "s370"}
{"text": " （4）需要在全身麻醉下进行外科择期手术且需要气管插管的手术患者，手术要求为经过适当术前准备的非急诊住院病人，1-2小时非开颅、非开胸手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s371"}
{"text": " 5.女性受试者未妊娠或产后至少6周并且未哺乳。筛查时需要对育龄女性进行妊娠检查，确定没有妊娠；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s372"}
{"text": " 2. 症状性心衰或严重心律失常；", "label": 4, "label_text": "Disease", "id": "s373"}
{"text": " 4.有临床意义的，活动性的（过去12个月）心血管疾病的受试者（病史包括心肌梗塞（MI），ECG所示心律失常或传导阻滞，不稳定性心绞痛，或失代偿心力衰竭（纽约心脏病学会[NYHA]分级为III级和IV级）", "label": 5, "label_text": "Multiple", "id": "s374"}
{"text": " (9) 入组前6个月内接受过LASIK手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s375"}
{"text": " ●存在没有控制的严重感染；例如：败血症；没有控制的肺炎（经适当抗生素治疗后X线胸片无明显改善）；没有控制的腹腔感染（经适当抗生素治疗后仍有腹膜炎体征、或腹水白细胞计数大于0.1×109／L）等。", "label": 5, "label_text": "Multiple", "id": "s376"}
{"text": " (5)过敏性体质或已知对本药成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s377"}
{"text": " 7、经内分泌治疗6个月体积仍大于55ml。", "label": 0, "label_text": "Therapy or Surgery", "id": "s378"}
{"text": " 7.合并有肝肾功能不全，AST或ALT超过正常值上限的1.5倍，肌酐超过正常值上限且有临床意义；", "label": 5, "label_text": "Multiple", "id": "s379"}
{"text": " 2.格列卫等药物服用史。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s380"}
{"text": " (5)自愿参加并与医师合作，签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s381"}
{"text": " 5. 依从性良好，截至2018年12月31日，有效随访时间（有CD4检测结果）超过2年；", "label": 8, "label_text": "Compliance with Protocol", "id": "s382"}
{"text": " （1）肥胖，BMI＞28kg/m2；", "label": 5, "label_text": "Multiple", "id": "s383"}
{"text": " （4）取得患者知情同意，愿意参加试验并配合随访。", "label": 5, "label_text": "Multiple", "id": "s384"}
{"text": " 4、患者严重的全身性疾病及严重精神疾病；", "label": 4, "label_text": "Disease", "id": "s385"}
{"text": " 2.术前分期为T1-3N0-1M0", "label": 24, "label_text": "Neoplasm Status", "id": "s386"}
{"text": " (4)合并有心、脑、肝或造血系统等严重原发疾病，恶性肿瘤及精神病患者；", "label": 4, "label_text": "Disease", "id": "s387"}
{"text": " 2)符合巴塞罗那肝癌分期标准；", "label": 24, "label_text": "Neoplasm Status", "id": "s388"}
{"text": " （3）门静脉主干完全被癌栓栓塞，且侧支血管形成少；", "label": 4, "label_text": "Disease", "id": "s389"}
{"text": " ③所有志愿者参加本次实验均为自愿，同时仔细阅读并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s390"}
{"text": " g)患者依从性好。", "label": 8, "label_text": "Compliance with Protocol", "id": "s391"}
{"text": " ②体力状况评分(KPS)<70分。", "label": 9, "label_text": "Risk Assessment", "id": "s392"}
{"text": " 6.依从性良好。", "label": 8, "label_text": "Compliance with Protocol", "id": "s393"}
{"text": "1) 帕金森综合症和帕金森叠加综合症。", "label": 4, "label_text": "Disease", "id": "s394"}
{"text": " 3.2.1.5 没有应用升压药或只需要小剂量的血管活性药物（多巴胺或去甲肾上腺素＜ 5 ~10ug／kg .min）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s395"}
{"text": " 随机对照研究：在横断面调查中GDS(老年抑郁自评量表)得分为11-25分者；自愿参加第二阶段研究者。", "label": 5, "label_text": "Multiple", "id": "s396"}
{"text": "①影像学检查提示合并肺炎、严重支气管扩张症者；", "label": 11, "label_text": "Diagnostic", "id": "s397"}
{"text": " 7. 患者拒绝参与研究或研究者认为不宜纳入本试验。", "label": 5, "label_text": "Multiple", "id": "s398"}
{"text": "1. 脊髓圆锥损伤患者；", "label": 4, "label_text": "Disease", "id": "s399"}
{"text": "⑴ 确诊HFMD危重症患儿(标准参照6.1.1.部分)；", "label": 11, "label_text": "Diagnostic", "id": "s400"}
{"text": " 7. 铂类化疗药物治疗后1年内复发者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s401"}
{"text": " 8. 预计生存期大于3个月。", "label": 23, "label_text": "Life Expectancy", "id": "s402"}
{"text": "急性心肌梗死；", "label": 4, "label_text": "Disease", "id": "s403"}
{"text": " （4）抗结核治疗期间使用其他肝损药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s404"}
{"text": "1.年龄55-80周岁（含55和80周岁），性别不限；", "label": 5, "label_text": "Multiple", "id": "s405"}
{"text": " 9.肠麻痹或者肠梗阻患者；", "label": 4, "label_text": "Disease", "id": "s406"}
{"text": " 5.至少有一个可测量病灶；", "label": 4, "label_text": "Disease", "id": "s407"}
{"text": "①ASA分级Ⅰ~Ⅱ；", "label": 9, "label_text": "Risk Assessment", "id": "s408"}
{"text": " ③接受单侧人工全膝关节置换术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s409"}
{"text": " ⑤已知对本研究中所用药物过敏的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s410"}
{"text": " ④妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s411"}
{"text": " 8.有张口困难、咽喉痛、声音嘶哑、咳嗽。", "label": 28, "label_text": "Symptom", "id": "s412"}
{"text": "  12.研究者认为受试者存在任何临床或实验室异常或依从性问题而不适宜参加本临床研究。", "label": 21, "label_text": "Researcher Decision", "id": "s413"}
{"text": " （3）术前临床分期为T1-4a，N0-3，M0（根据AJCC-7thTNM肿瘤分期）；", "label": 24, "label_text": "Neoplasm Status", "id": "s414"}
{"text": "   2) 系统性疾病及情绪不稳定者；", "label": 4, "label_text": "Disease", "id": "s415"}
{"text": " 3.所有患者的ASA分级为Ⅰ-Ⅱ级", "label": 9, "label_text": "Risk Assessment", "id": "s416"}
{"text": " 4）不能完整完成研究，依从性不好者", "label": 8, "label_text": "Compliance with Protocol", "id": "s417"}
{"text": "          C、多囊卵巢", "label": 4, "label_text": "Disease", "id": "s418"}
{"text": " 8）心电图、胸片、超声、肝、肾功能异常，且存在临床意义；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s419"}
{"text": " 8. 近 1 个月内服用过肠道微生态制剂、抗生素或抗抑郁药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s420"}
{"text": "1)可以进行外科肿瘤切除或局部消融者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s421"}
{"text": " （3）严重脱水和重度营养不良者或Hb＜10g/dl；", "label": 5, "label_text": "Multiple", "id": "s422"}
{"text": " 3、符合DSM-Ⅴ或者ICD-10精神疾病诊断标准（包括精神病性症状、情感障碍等）；", "label": 5, "label_text": "Multiple", "id": "s423"}
{"text": " （4）术前感染指标异常", "label": 4, "label_text": "Disease", "id": "s424"}
{"text": " 2. 对研究疫苗中任一成分过敏者（包括氯化钠、氯化钾、磷酸二氢钾、磷酸氢二钠、蔗糖、谷氨酸钠、红霉素），既往有任何疫苗接种严重过敏史者", "label": 7, "label_text": "Allergy Intolerance", "id": "s425"}
{"text": "①肝功能异常（谷丙和谷草转氨酶>2倍正常值上限）;或肾功能异常（血肌酐水平>正常值上限）; WBC<4×10E9 / L或血小板<100×10E9 / L或甲状腺功能亢进，糖尿病等内分泌疾病的患者;", "label": 5, "label_text": "Multiple", "id": "s426"}
{"text": " （4）无其他特殊病史：造血系统疾病、遗传代谢型疾病等。", "label": 4, "label_text": "Disease", "id": "s427"}
{"text": "①皮损以点滴状为主，或皮损单独见于颜面、头皮、指甲、皱折、龟头、粘膜、掌跖部位的患者。", "label": 1, "label_text": "Sign", "id": "s428"}
{"text": " 15. 研究者认为具有其他不适宜参加本试验因素的参试者.", "label": 21, "label_text": "Researcher Decision", "id": "s429"}
{"text": " 其他形式的肝病，如：酒精性肝病、自身免疫性肝病、胆汁淤积性肝病、肝脏肿瘤等", "label": 4, "label_text": "Disease", "id": "s430"}
{"text": " 4、患者有严重或不可控制的细菌，病毒或真菌感染；", "label": 4, "label_text": "Disease", "id": "s431"}
{"text": " 10.给药前2天内受试者平均脉搏<50或>100 bpm；平均收缩压<90或>140 mmHg；平均舒张压<50或>90 mmHg，如果平均脉搏或血压超过上限值，且复测仍异常者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s432"}
{"text": " 4.急性心衰；", "label": 4, "label_text": "Disease", "id": "s433"}
{"text": " （4）患精神障碍疾病者", "label": 4, "label_text": "Disease", "id": "s434"}
{"text": " 4. 合并其他肿瘤或有严重并发症或肝、肾、心脏功能不全者；", "label": 5, "label_text": "Multiple", "id": "s435"}
{"text": " 6.失访，未能获得明确诊断。", "label": 5, "label_text": "Multiple", "id": "s436"}
{"text": " 5.无远处转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s437"}
{"text": " 5.严重的心动过缓并且无临时起搏器", "label": 5, "label_text": "Multiple", "id": "s438"}
{"text": " 3、ASA分级：Ⅰ--Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s439"}
{"text": "1.符合产后下腰痛的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s440"}
{"text": " b、年龄18-65岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s441"}
{"text": " 2 病理性骨折", "label": 4, "label_text": "Disease", "id": "s442"}
{"text": " 7. 根据研究者判断，具有降低入组可能性或使入组复杂化的其他病变或情况，如生活环境不稳定，交通不便等易造成失访的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s443"}
{"text": " ④ 肝功能Child-Pugh A或B级；", "label": 9, "label_text": "Risk Assessment", "id": "s444"}
{"text": "北京市区60岁以上的健康老年妇女；", "label": 5, "label_text": "Multiple", "id": "s445"}
{"text": " 9)入选前2周内完成与肿瘤疗效评价有关的影像学检查，入选前1周内行临床症状病情评估，血尿粪三大常规、血生化、心电图、CEA等检查；", "label": 5, "label_text": "Multiple", "id": "s446"}
{"text": " ②K-L分级为I-III；", "label": 9, "label_text": "Risk Assessment", "id": "s447"}
{"text": " 2.中医虚证的诊断标准  MDS在西医诊断的基础上，按照《中药新药临床研究指导原则》，拟定虚证的主要症状标准如下。主症  面色欠华、头昏头晕、神疲乏力、心悸失眠、眩晕耳鸣、口咽干燥，潮热汗出、形寒肢冷、胃纳减退、大便干燥或溏烂、或衄血、苔薄白/白或少苔、舌淡或胖嫩伴齿痕或舌红，脉细或细数。有上述症状2项或以上，加舌苔和/或脉象即可诊断。", "label": 5, "label_text": "Multiple", "id": "s448"}
{"text": "1.脊柱原发肿瘤；", "label": 4, "label_text": "Disease", "id": "s449"}
{"text": " 3.不能依从本研究步骤者", "label": 8, "label_text": "Compliance with Protocol", "id": "s450"}
{"text": "1.符合MPP的西医诊断标准及中医辨证标准的患儿；", "label": 11, "label_text": "Diagnostic", "id": "s451"}
{"text": " ③合并肿瘤、严重心、肝、肾、造血系统和内分泌系统等严重原发性疾病；", "label": 4, "label_text": "Disease", "id": "s452"}
{"text": " -血清肌酐≤1.5倍正常上限值，", "label": 12, "label_text": "Laboratory Examinations", "id": "s453"}
{"text": " 5)由研究者判断的反复发作的主要低血糖事件。", "label": 21, "label_text": "Researcher Decision", "id": "s454"}
{"text": " ④美国麻醉医师协会 (American Society of Anesthesiologists, ASA)评级为I或II级；", "label": 9, "label_text": "Risk Assessment", "id": "s455"}
{"text": " （2）糖尿病足Ⅱ～Ⅲ级；", "label": 4, "label_text": "Disease", "id": "s456"}
{"text": " 4)符合WHO对不孕症的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s457"}
{"text": " 7.精神状态不能合作者，患有精神性疾病、无自制力、不能明确表达者；", "label": 5, "label_text": "Multiple", "id": "s458"}
{"text": " 2)能够按照试验方案要求完成研究；", "label": 8, "label_text": "Compliance with Protocol", "id": "s459"}
{"text": " （10）MMSE简易精神状态检查量表≤24分者。", "label": 9, "label_text": "Risk Assessment", "id": "s460"}
{"text": " （4）有消化系统器质性病变(如慢性胰腺炎等)，或有影响消化道动力的全身疾病(例如:糖尿病、慢性肾功能不全、结缔组织病、精神和神经系统病变等)。", "label": 4, "label_text": "Disease", "id": "s461"}
{"text": " 8.合并脑水肿、严重感染（包括感染性休克、深部真菌感染、2个部位以上感染、二重感染等）、I 型肝肾综合征、消化道大出血等患者；", "label": 4, "label_text": "Disease", "id": "s462"}
{"text": " 7.入选前2周至一年间至少有1次严重哮喘急性发作", "label": 4, "label_text": "Disease", "id": "s463"}
{"text": " （10） 筛选前2周内服用过任何药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s464"}
{"text": "（1）合并心、脑、肝、肾、造血系统和内分泌系统等严重原发性疾病，高血糖、低蛋白、电解质紊乱等功能异常（实验室指标参照各研究中心仪器的正常值，有效区间为正常值的20%以外）；ABI≤0.2", "label": 5, "label_text": "Multiple", "id": "s465"}
{"text": " 7.无慢性消化道疾病史，无致慢性恶心呕吐病史（如眩晕、美尼尔综合症病史）；", "label": 4, "label_text": "Disease", "id": "s466"}
{"text": " 5、有肿瘤家族史者。", "label": 4, "label_text": "Disease", "id": "s467"}
{"text": "1、肿瘤ER阳性≥50%；", "label": 24, "label_text": "Neoplasm Status", "id": "s468"}
{"text": "1.病人有其他恶性疾病，如淋巴瘤和间质瘤等；有其他严重的合并症；", "label": 4, "label_text": "Disease", "id": "s469"}
{"text": " （4）40 U/L≦谷丙转氨酶（ALT）<200 U/L，40 U/L≦谷草转氨酶（AST）<200 U/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s470"}
{"text": " 8）孕期或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s471"}
{"text": " 4 恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s472"}
{"text": "(1)拟接受体外循环的心脏手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s473"}
{"text": " （2）严重的心血管疾病", "label": 4, "label_text": "Disease", "id": "s474"}
{"text": " 5.有酗酒、毒物依赖者", "label": 2, "label_text": "Addictive Behavior", "id": "s475"}
{"text": " （2）患者合并急性冠脉综合征（包括急性心肌梗死、不稳定型心绞痛）、严重心律失常（重度房室传导阻滞、室性心动过速、影响学流动力学的室上性心动过速、频发早搏特别是室性早搏，房颤），原发性心肌病、瓣膜性心脏病；", "label": 4, "label_text": "Disease", "id": "s476"}
{"text": " 7.接受药物成瘾或酒精中毒治疗或具有药物成瘾或酒精中毒病史的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s477"}
{"text": " 8)有嗜烟史（超过5支/天或使用相当量的尼古丁产品）、酗酒史（每周饮酒超过14个酒精单位：1个酒精单位等于10mL或8g纯酒精，25 mL 40%白酒、330 mL 5%啤酒、175mL 12%红酒分别约合1.0、1.5、2.0个酒精单位）、药物滥用史、吸毒史者；", "label": 2, "label_text": "Addictive Behavior", "id": "s478"}
{"text": " （2）年龄18岁-75岁；", "label": 3, "label_text": "Age", "id": "s479"}
{"text": "(1)妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s480"}
{"text": " c)文身病程大于1月。", "label": 4, "label_text": "Disease", "id": "s481"}
{"text": " （5）研究者认为不适宜纳入研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s482"}
{"text": " （2）排除甲旁亢、cushing 综合征等疾病、长期服用类固醇激素等药物、长期慢性消化道疾病、胃肠手术等造成营养吸收障碍等因素所引起的继发性骨质疏松。", "label": 5, "label_text": "Multiple", "id": "s483"}
{"text": "   2.自愿入组并按时服药、定时随访者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s484"}
{"text": " 3、体重指数（BMI）在19－24 kg/㎡之间；", "label": 9, "label_text": "Risk Assessment", "id": "s485"}
{"text": " ③既往有出血性疾病史。", "label": 4, "label_text": "Disease", "id": "s486"}
{"text": "18岁以上，因脓毒症转入ICU的患者，并至少符合2条或2条以上以下诊断标准：", "label": 5, "label_text": "Multiple", "id": "s487"}
{"text": " （5）三个月内用过已知对某脏器有损害的药物或目前正在使用药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s488"}
{"text": " 6.进行过胃肠道手术，除阑尾炎、疝气手术外；", "label": 0, "label_text": "Therapy or Surgery", "id": "s489"}
{"text": " 4. 签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s490"}
{"text": " ⑥正在参加影响本研究结果评价的其它临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s491"}
{"text": " 11. 幽门螺杆菌测试阳性——根治后可以入组", "label": 12, "label_text": "Laboratory Examinations", "id": "s492"}
{"text": "1.绝经后妇女，50-70岁；", "label": 5, "label_text": "Multiple", "id": "s493"}
{"text": "①严重感染，预计生存期可能小于试验治疗周期（至少8天）；", "label": 23, "label_text": "Life Expectancy", "id": "s494"}
{"text": " 6. 有P活动性溃疡、出血等疾病的患者；", "label": 4, "label_text": "Disease", "id": "s495"}
{"text": " -在首次用药前2个月内进行过大手术或受严重外伤的患者；", "label": 5, "label_text": "Multiple", "id": "s496"}
{"text": " 8.  DSA显示肿瘤供血动脉含脊髓前动脉；动脉过于纤细、插管不成功者；", "label": 24, "label_text": "Neoplasm Status", "id": "s497"}
{"text": " 2)术前访视血压≥180/110 mm Hg（WHO-ISH高血压指南3级高血压）；", "label": 5, "label_text": "Multiple", "id": "s498"}
{"text": " (7)随访期间病情进入复发期者。", "label": 5, "label_text": "Multiple", "id": "s499"}
{"text": "1)受试者自愿参加此项研究并且遵守研究规定，并自愿签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s500"}
{"text": " 1.6.Karnofsky体力状况评分>=70", "label": 9, "label_text": "Risk Assessment", "id": "s501"}
{"text": " 9.存在肝素使用禁忌/抗凝禁忌，肝素过敏/HIT", "label": 5, "label_text": "Multiple", "id": "s502"}
{"text": "(1) 年龄≧18周岁、≦65周岁，男女均可；", "label": 5, "label_text": "Multiple", "id": "s503"}
{"text": " 8.存在严重的、未经良好控制的躯体及精神疾病的患者（如：精神分裂症、双相障碍、抑郁障碍等）；", "label": 4, "label_text": "Disease", "id": "s504"}
{"text": " 5）可滤过或透析的药物过量；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s505"}
{"text": " b.确诊多囊卵巢综合症（按照2003年鹿特丹诊断标准）。", "label": 11, "label_text": "Diagnostic", "id": "s506"}
{"text": "1.移植患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s507"}
{"text": "术前发热，白细胞升高及术前感染，伴全身炎症性疾病；", "label": 5, "label_text": "Multiple", "id": "s508"}
{"text": " 6)知情同意", "label": 13, "label_text": "Consent", "id": "s509"}
{"text": " 4、门静脉海绵样变", "label": 4, "label_text": "Disease", "id": "s510"}
{"text": " (2) 入院诊断为VTE的患者，或入院后48小时内诊断为VTE的患者，以排除院前VTE；", "label": 11, "label_text": "Diagnostic", "id": "s511"}
{"text": "  4．有精神疾患、不能配合作者", "label": 4, "label_text": "Disease", "id": "s512"}
{"text": " （2）病灶需穿刺活检或手术得到明确病理诊断。", "label": 5, "label_text": "Multiple", "id": "s513"}
{"text": "（1）中枢性性早熟；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s514"}
{"text": " 9)6月以内心梗等心血管疾患*", "label": 4, "label_text": "Disease", "id": "s515"}
{"text": " ④　更年期相关症状(FSH≥25IU/L)。", "label": 5, "label_text": "Multiple", "id": "s516"}
{"text": "（1）18-45岁女性；", "label": 5, "label_text": "Multiple", "id": "s517"}
{"text": " 2.在术后病人使用自控硬膜外镇痛(PCEA)和术后静脉镇痛(PCIA)", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s518"}
{"text": " 4．酒精或其它药物滥用者；", "label": 2, "label_text": "Addictive Behavior", "id": "s519"}
{"text": "①病程未超过36h，但已经接受相关药物治疗，如抗生素、抗病毒药、激素类药物、解热镇痛药、说明书标明用于治疗流感的药物。", "label": 5, "label_text": "Multiple", "id": "s520"}
{"text": " 4）自愿接受本治疗并愿意在随访期内保持原有治疗药物不变。", "label": 5, "label_text": "Multiple", "id": "s521"}
{"text": " ①主观报告记忆力下降，最好有知情人提供信息佐证；", "label": 28, "label_text": "Symptom", "id": "s522"}
{"text": " （3）自愿参加本研究", "label": 13, "label_text": "Consent", "id": "s523"}
{"text": " 无病毒、细菌感染等疾病；", "label": 4, "label_text": "Disease", "id": "s524"}
{"text": " （3）符合高血压危险分级：低危或中危，且导入期后坐位舒张压90-99mmHg，或收缩压140-159mmHg的1级高血压患者；", "label": 5, "label_text": "Multiple", "id": "s525"}
{"text": "（1）患有高度近视（近视度数大于600度以上）或其它眼部疾病者；", "label": 4, "label_text": "Disease", "id": "s526"}
{"text": " ⑽  近三个月内参加过其他药物或医疗器械临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s527"}
{"text": "1.患有任何其它多重原发癌；", "label": 4, "label_text": "Disease", "id": "s528"}
{"text": " ?血常规：血红蛋白（Hb）≥90 g/L，白细胞数（WBC）≥3.5×109/L，中性粒细胞数（ANC）≥1.5×109/L， 血小板数（PLT）≥ 100×109/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s529"}
{"text": " 6)妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s530"}
{"text": " 5)用过任何排泄期长可能影响本研究的药品，或正在使用任何药品者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s531"}
{"text": " 7. 近三个月内参加过其它临床试验的；", "label": 15, "label_text": "Enrollment in other studies", "id": "s532"}
{"text": " 2.1、2型糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s533"}
{"text": " 9)临床上有显著的变态反应史，特别是药物过敏史，尤其对恩替卡韦及辅料中任何成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s534"}
{"text": " 4.患有急慢性呼吸道感染患者；", "label": 4, "label_text": "Disease", "id": "s535"}
{"text": " 2. 300mg/g(> 30mg/mmol) >ACR≥30mg/g(3mg/mmol)。", "label": 12, "label_text": "Laboratory Examinations", "id": "s536"}
{"text": " ⑵智力异常或任何妨碍对知情同意书理解的精神疾病。", "label": 5, "label_text": "Multiple", "id": "s537"}
{"text": " 9）研究者认为有任何不适合入选情况者。", "label": 21, "label_text": "Researcher Decision", "id": "s538"}
{"text": " 4)未治疗时动脉血氧分压≤50mmhg  动脉血氧饱和度≤70%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s539"}
{"text": " 5、研究者认为其他原因不适合临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s540"}
{"text": "1.年龄≥75岁；", "label": 3, "label_text": "Age", "id": "s541"}
{"text": "  —既往使用过顺铂且累积剂量超过300mg/m2者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s542"}
{"text": " d) 具有以下一种月经相关症状：有经前紧张症状；或有痛经症状；", "label": 1, "label_text": "Sign", "id": "s543"}
{"text": " 矫正视力≥0.15（国家标准对数视力表5米处测试）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s544"}
{"text": " （14）全身极度衰竭；", "label": 4, "label_text": "Disease", "id": "s545"}
{"text": " h. 既往有肾脏疾病；", "label": 4, "label_text": "Disease", "id": "s546"}
{"text": " (8)已知对本药成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s547"}
{"text": " 2)患者有明显的临床症状。", "label": 28, "label_text": "Symptom", "id": "s548"}
{"text": " 5、高血压Ⅱ期以上（包括Ⅱ期，160~179或100~109 mmHg为高血压Ⅱ期）；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s549"}
{"text": " (2)HBsAg阳性≥6月；", "label": 12, "label_text": "Laboratory Examinations", "id": "s550"}
{"text": "①经病理或细胞学证实为恶性肿瘤者；", "label": 11, "label_text": "Diagnostic", "id": "s551"}
{"text": " ④ 拒绝接受随访者。", "label": 13, "label_text": "Consent", "id": "s552"}
{"text": " 3.患有精神疾患，或有严重的认知障碍，不能参与合作的患者；", "label": 5, "label_text": "Multiple", "id": "s553"}
{"text": " 5、使用可能会影响试验结果的药物，且停药时间少于规定时间者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s554"}
{"text": " ⑷螺旋型鼻肠管常规置管失败者；", "label": 34, "label_text": "Device", "id": "s555"}
{"text": " 10.严重肺部或心脏疾病病史者。", "label": 4, "label_text": "Disease", "id": "s556"}
{"text": " 5  有明确的MRI、CT、B超等影像学、甲胎蛋白(AFP)或肝脏穿刺行细胞学检查确诊；", "label": 11, "label_text": "Diagnostic", "id": "s557"}
{"text": " ④签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s558"}
{"text": " （7）由于智力或行为障碍，不能配合完成临床观察者；", "label": 5, "label_text": "Multiple", "id": "s559"}
{"text": " 2.入选时明确合并细菌感染。", "label": 4, "label_text": "Disease", "id": "s560"}
{"text": " 5、近6个月内发生卒中或猝死；", "label": 4, "label_text": "Disease", "id": "s561"}
{"text": " 6）血小板减少（PLT<100g/L）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s562"}
{"text": "1.患者已被确诊子宫肌瘤，B超检查肌瘤的长、宽、厚度均大于3cm并且小于7cm者（换算成肌瘤体积为14cm3-180cm3之间，肌瘤体积计算：体积（cm3）=长度X宽度X0.5236）；", "label": 5, "label_text": "Multiple", "id": "s563"}
{"text": " ③从重症监护室转入或转出至重症监护室。", "label": 26, "label_text": "Encounter", "id": "s564"}
{"text": " f） 恶性肿瘤", "label": 4, "label_text": "Disease", "id": "s565"}
{"text": " 2)1周岁～6周岁", "label": 3, "label_text": "Age", "id": "s566"}
{"text": " 5.双眼近视度数差异≥150度", "label": 12, "label_text": "Laboratory Examinations", "id": "s567"}
{"text": " (3) 签署知情同意，自愿并坚持参加研究及随访。", "label": 5, "label_text": "Multiple", "id": "s568"}
{"text": " h)研究前自愿签署知情同意书，患者和/或其法定代理人有能力对试验内容、过程及可能出现的不良反应充分了解，并能使患者遵守方案规定的访视；", "label": 5, "label_text": "Multiple", "id": "s569"}
{"text": " 5. 妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s570"}
{"text": "    5）取卵日已经出现了卵巢过度刺激的症状", "label": 1, "label_text": "Sign", "id": "s571"}
{"text": " 6)半乳糖血症与粘多糖疾病等酶的缺陷及遗传性因素所致的不孕症。", "label": 4, "label_text": "Disease", "id": "s572"}
{"text": " 17.其他任何研究者判断任何不宜参加试验的情况", "label": 21, "label_text": "Researcher Decision", "id": "s573"}
{"text": " 5. 二度、三度房室阻滞；", "label": 4, "label_text": "Disease", "id": "s574"}
{"text": " ③有眼部疾病，如眼表炎症、圆锥角膜、眼部肿瘤、青光眼等", "label": 4, "label_text": "Disease", "id": "s575"}
{"text": " (7)合并心血管、肝、肾、脑和造血系统等严重原发疾病，恶性肿瘤，精神病患者", "label": 4, "label_text": "Disease", "id": "s576"}
{"text": " 4、年龄相关性白内障：排除并发性、外伤性、先天性白内障并排除伴有其他眼内疾病者、排除过熟期病例", "label": 4, "label_text": "Disease", "id": "s577"}
{"text": " 10. 重要脏器存在严重问题：包括但不限于心脑血管（未控制的高血压病：收缩压≥160mmHg和/或舒张压≥95mmHg、心力衰竭：纽约心脏协会分级III/ IV级）、神经系统、肝脏、肾脏（血清肌酐水平>2.0mg/dl（176.8μmol/L）、血液系统（入组时白细胞（WBC）计数<2500个/μl，或血小板<100000个/μl或中性粒细胞<1500个/μl或血红蛋白<8.5g/dl）疾病；既往淋巴增殖性疾病史；入组前5年内恶性肿瘤病史者（经过治疗且12周内无再发证据的Bowen病、基底细胞癌、光化性角化病及已被切除的宫颈原位癌或非侵袭性恶性结肠息肉除外）；先天性免疫缺陷或免疫力低下者；", "label": 5, "label_text": "Multiple", "id": "s578"}
{"text": " 6中性粒细胞＞1.5×109/L，血小板＞100×109/L，血红蛋白＞9.0g/dl；胆红素 正常或 < 1.5 × ULN；AST (SGOT)、ALT (SGPT) < 2.5 ×ULN (如果肝转移则< 5 ×ULN)；血清肌酐< 1.5 ×ULN；", "label": 12, "label_text": "Laboratory Examinations", "id": "s579"}
{"text": " (2)合并肛裂、肛瘘以及肛周脓肿等肛门良性疾病者；", "label": 4, "label_text": "Disease", "id": "s580"}
{"text": "1.年龄为18-65岁的女性患者；", "label": 5, "label_text": "Multiple", "id": "s581"}
{"text": " 7.红细胞压积> 55%的受试者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s582"}
{"text": " 6.患者愿意参加本研究且签署知情同意书（若未足法定年龄者需由法定监护人签署）。", "label": 13, "label_text": "Consent", "id": "s583"}
{"text": " 7、用药情况：1）月内未接受过化疗；2）3月内未接受过其他免疫治疗。", "label": 5, "label_text": "Multiple", "id": "s584"}
{"text": " 4. 自愿参加并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s585"}
{"text": "1）GFR＜45 ml/min/1.73m2；", "label": 12, "label_text": "Laboratory Examinations", "id": "s586"}
{"text": " （9）治疗前3个月内曾参加过其他药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s587"}
{"text": " 2）甲状腺微小乳头状癌内存在粗大钙化灶；", "label": 4, "label_text": "Disease", "id": "s588"}
{"text": " 2、严重心、肺、肝或肾疾病不能耐受手术；", "label": 5, "label_text": "Multiple", "id": "s589"}
{"text": " 6)最近一次治疗所带来的毒副作用应得到了恢复，与最近一次化疗至少间隔4周；最近一次的免疫治疗至少经过3个半衰时间；", "label": 0, "label_text": "Therapy or Surgery", "id": "s590"}
{"text": "1.合并严重重要器官器质性病变恶性高血压心肌梗塞病史心力衰竭肝肾功能衰竭等；", "label": 5, "label_text": "Multiple", "id": "s591"}
{"text": " 随机分配前 6 个月内发生过急性冠状动脉综合征事件", "label": 4, "label_text": "Disease", "id": "s592"}
{"text": " (3)已知或怀疑对本研究药物过敏者或过敏体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s593"}
{"text": " 3.无法或拒绝采集肿瘤样本；", "label": 8, "label_text": "Compliance with Protocol", "id": "s594"}
{"text": " c. 肿瘤侵犯颈段小关节突、椎弓根，或者侵犯三柱中的两柱；", "label": 4, "label_text": "Disease", "id": "s595"}
{"text": " （2）一个月内的心肌梗死；", "label": 4, "label_text": "Disease", "id": "s596"}
{"text": " 2、近3个月服用抗生素或类固醇药物过度饮酒（>6瓶/天）；", "label": 5, "label_text": "Multiple", "id": "s597"}
{"text": " 3.轻度/中度非增殖期糖尿病视网膜病变患者（NPDR）（ETDRS<47）。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s598"}
{"text": " 在开展任何试验相关活动之前已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s599"}
{"text": " 12)最近在饮食或运动习惯上有重大变化；", "label": 5, "label_text": "Multiple", "id": "s600"}
{"text": " 4.研究开始前6月内接受过系统激素、免疫抑制剂治疗或未来预期将要接受激素、免疫抑制剂治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s601"}
{"text": "①正在参加其它临床试验的患者", "label": 15, "label_text": "Enrollment in other studies", "id": "s602"}
{"text": " 3) 术中证实为转移性胃癌", "label": 4, "label_text": "Disease", "id": "s603"}
{"text": " （3）受试者无主要器官的功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s604"}
{"text": " ⑷受试者知情同意，自愿受试并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s605"}
{"text": " （2）有严重呼吸系统、心血管疾病及肝肾功能异常患者（ALT、AST 超过正常值上限的1.5倍和BUN、Cr 超过正常值即为异常）；", "label": 5, "label_text": "Multiple", "id": "s606"}
{"text": " 9) 首次用药前经实验室检查证实患者骨髓功能、肝肾功能满足下列要求：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s607"}
{"text": " 9. 其他研究者认为不宜参加研究的原因。", "label": 21, "label_text": "Researcher Decision", "id": "s608"}
{"text": " （3）术中造影发现主裂口位置距离左锁骨下动脉开口<1cm者。", "label": 11, "label_text": "Diagnostic", "id": "s609"}
{"text": " 2)术前使用任何已知会影响脑电图的药物，例如抗精神病药物、镇静药物、抗癫痫药物、中枢神经兴奋剂，包括酗酒；", "label": 5, "label_text": "Multiple", "id": "s610"}
{"text": " (4)所有参与试验的研究对象均对该研究知情同意、自愿参加并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s611"}
{"text": "1.病人不能同时适合行手术切除和射频消融治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s612"}
{"text": " (2).阿托品用药禁忌者；", "label": 4, "label_text": "Disease", "id": "s613"}
{"text": " （5）病人无肝内转移或肝外转移,如腹部转移和肺转移,术前诊断使用CT、MRI或胸片,同时在术中也应该使用术中超声再次确认。", "label": 4, "label_text": "Disease", "id": "s614"}
{"text": " （4）耳穴部位皮肤破损以及胶布过敏者；", "label": 5, "label_text": "Multiple", "id": "s615"}
{"text": "1. DM酮症酸中毒、DM高渗性综合征者；", "label": 4, "label_text": "Disease", "id": "s616"}
{"text": " （2）体质指数：18-28。", "label": 9, "label_text": "Risk Assessment", "id": "s617"}
{"text": " 4)年龄18 ~ 60岁，", "label": 3, "label_text": "Age", "id": "s618"}
{"text": "a. 年龄18-70岁；体力状况：ECOG 0－2分；", "label": 5, "label_text": "Multiple", "id": "s619"}
{"text": "1）同时患有其它部位恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s620"}
{"text": " （5）非HBV的其他病毒感染的急慢性肝炎、HCV感染、HDV感染、自身免疫性肝炎、原发性胆汁性肝硬化、原发性硬化性胆管炎、遗传代谢性肝病、药物或毒物性肝炎、酒精性肝病；", "label": 4, "label_text": "Disease", "id": "s621"}
{"text": " ⑦ 家庭住址在北京市；", "label": 40, "label_text": "Address", "id": "s622"}
{"text": " 2. 肛门手术患者;", "label": 0, "label_text": "Therapy or Surgery", "id": "s623"}
{"text": "1）存在复合伤：多发骨折，合并头部、胸部、腹部、骨盆等髋部以外的部位存在的外伤；", "label": 4, "label_text": "Disease", "id": "s624"}
{"text": " 4、能提供详细的联络方式，无短期迁徙，愿意配合随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s625"}
{"text": "（1）近期肺部CT发现不明原因8mm≦肺外周病变≦3cm，首次行经支气管镜肺活检检查的患者。", "label": 34, "label_text": "Device", "id": "s626"}
{"text": " 5.最近一年内曾接受过特定免疫疗法或系统激素治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s627"}
{"text": " 6.肝活检或其他有效非创伤性标志物显示为肝脏病理证实肝细胞中度至重度活动性坏死炎症和(或)纤维化METAVIR 评分至少A2级或F2期；", "label": 5, "label_text": "Multiple", "id": "s628"}
{"text": " （8）有一定文化程度，既往能阅读简单的文章和书写简单的句子；", "label": 25, "label_text": "Literacy", "id": "s629"}
{"text": " 16)可能因为其他原因而不能完成本研究的受试者。", "label": 17, "label_text": "Capacity", "id": "s630"}
{"text": " （4）妊娠期或哺乳期女性患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s631"}
{"text": " 2符合产后出血诊断标准并且虽经过积极地病因治疗和充分的液体复苏血流动力学仍不稳定而需要血管活性药物治疗的患者。", "label": 5, "label_text": "Multiple", "id": "s632"}
{"text": " 没有知情同意书的病人。", "label": 13, "label_text": "Consent", "id": "s633"}
{"text": "A. 高血压患者且血压无法控制者；", "label": 4, "label_text": "Disease", "id": "s634"}
{"text": " 5)严重视力或听力障碍", "label": 4, "label_text": "Disease", "id": "s635"}
{"text": " 3) 取卵周期未进行移植或移植后未孕、有冻存胚胎者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s636"}
{"text": "（1）由精神科执业医师临床诊断为不伴有精神病性症状的抑郁障碍，并符合美国精神疾病诊断和统计手册第IV版（Diagnostic and Statistical Manual of Mental Disorders-IV，DSM-IV）中不伴有精神病性症状的抑郁障碍诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s637"}
{"text": " 2.病灶位于支气管束2cm以内。", "label": 24, "label_text": "Neoplasm Status", "id": "s638"}
{"text": " 长期服用抗精神病药物的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s639"}
{"text": " 1.有哮喘样表现的其他疾病，如先天性心脏病、胃食管反流、支气管肺发育不良、闭塞性细支气管炎等", "label": 5, "label_text": "Multiple", "id": "s640"}
{"text": " 2.年龄在60-85岁之间。", "label": 3, "label_text": "Age", "id": "s641"}
{"text": " e)存在应用褪黑素禁忌，如对褪黑素活性成分或辅料过敏等；", "label": 5, "label_text": "Multiple", "id": "s642"}
{"text": " 4.半年内曾使用过激素、降钙素或其他影响骨代谢的药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s643"}
{"text": " 2.年龄18-75周岁；", "label": 3, "label_text": "Age", "id": "s644"}
{"text": " 2、风湿或类风湿性关节炎；", "label": 4, "label_text": "Disease", "id": "s645"}
{"text": " 10、在过去的12个月内参与其他肺康复计划。", "label": 0, "label_text": "Therapy or Surgery", "id": "s646"}
{"text": " ③ 年龄在40岁-60岁之间（包括40岁和60岁）；", "label": 3, "label_text": "Age", "id": "s647"}
{"text": " 16)临床实验室检查有临床意义异常、或其它临床发现显示有临床意义的下列疾病（包括但不限于胃肠道、肾、肝、神经、血液、内分泌、肿瘤、肺、免疫、精神或心脑血管疾病）。", "label": 5, "label_text": "Multiple", "id": "s648"}
{"text": " 妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s649"}
{"text": " ⑵术前曾做过抗肿瘤治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s650"}
{"text": " （6）受试者表明愿意并完成研究中所有步骤和研究干预周期；", "label": 13, "label_text": "Consent", "id": "s651"}
{"text": " 3. 无心血管病史;", "label": 4, "label_text": "Disease", "id": "s652"}
{"text": "1. 预期生存率小于12个月。", "label": 23, "label_text": "Life Expectancy", "id": "s653"}
{"text": " （3）BMI＜28kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s654"}
{"text": "（1）合并心、肺、肾、脑、血液等重要脏器严重疾病患者；", "label": 4, "label_text": "Disease", "id": "s655"}
{"text": " 5.签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s656"}
{"text": " 25)根据研究者的判断，不适合参加本试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s657"}
{"text": " 2）现患有或既往患有抑郁、焦虑、物质滥用等精神系统疾病；", "label": 4, "label_text": "Disease", "id": "s658"}
{"text": " （6）符合本课题要求的MRI检查结果；", "label": 11, "label_text": "Diagnostic", "id": "s659"}
{"text": " 3.对其相关药物、辅料过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s660"}
{"text": " （11）有研究者认为不适合入选本项研究的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s661"}
{"text": " 3)受试者（包括男性受试者）愿意未来6个月内无妊娠计划且自愿采取有效避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s662"}
{"text": " 3）存在脑功能紊乱的临床症状或严重的精神性疾病不能理解或遵从研究方案；", "label": 5, "label_text": "Multiple", "id": "s663"}
{"text": " 5，患者有显著地系统性疾病。", "label": 4, "label_text": "Disease", "id": "s664"}
{"text": "1)未纠正的全身出血性疾病；", "label": 4, "label_text": "Disease", "id": "s665"}
{"text": " 4、由于其他原因导致无法继续本临床试验者", "label": 8, "label_text": "Compliance with Protocol", "id": "s666"}
{"text": " （4）术前已确定无干眼症者。", "label": 4, "label_text": "Disease", "id": "s667"}
{"text": " ⑤其他原因导致手术禁忌者。", "label": 4, "label_text": "Disease", "id": "s668"}
{"text": " （2）怀疑HCC肝外转移或者除HCC外合并其他类型肿瘤者；", "label": 24, "label_text": "Neoplasm Status", "id": "s669"}
{"text": " -合并恶性肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s670"}
{"text": " 12)对试验药或对照药已知成份过敏及过敏体质者或ESAs抵抗者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s671"}
{"text": " （4）饮食依从性差；", "label": 8, "label_text": "Compliance with Protocol", "id": "s672"}
{"text": " 2）既往月经规律，有过妊娠史", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s673"}
{"text": " 10）在研究期间需长期服用方案以外的非甾体类抗炎药、激素、免疫调节和化疗药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s674"}
{"text": " 2. 已确诊由其他疾病引起的高脂血症，如因肾病综合征、甲状腺功能减退、痛风、严重肝胆疾病（病毒性肝炎、胆囊炎、胆石症）等所致的继发性高脂血症；已知的家族性高脂血症患者；由药物(吩噻嗪类、β受体阻滞剂、肾上腺皮质类固醇及某些避孕药等)引起的高脂血症及已知的纯合子型高胆固醇症者；", "label": 4, "label_text": "Disease", "id": "s675"}
{"text": " 2、排除既往有慢性疾病史；", "label": 4, "label_text": "Disease", "id": "s676"}
{"text": " （5）合并其他严重内脏器官疾病者；", "label": 4, "label_text": "Disease", "id": "s677"}
{"text": " (6).同意在接受研究药物治疗后至少6个月内采取充分的预防措施防止自己及配偶妊娠（例如避孕药、子宫避孕器械或者采用杀精剂的防护性措施）；", "label": 5, "label_text": "Multiple", "id": "s678"}
{"text": " 5、孕妇或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s679"}
{"text": " 9.绝对淋巴细胞计数 ≥ 100/ uL；", "label": 12, "label_text": "Laboratory Examinations", "id": "s680"}
{"text": " 4)（问诊）血小板低于正常值下限的20%者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s681"}
{"text": " （5）本人或未成年患者的家长有通过手术改善患肢的愿望；", "label": 5, "label_text": "Multiple", "id": "s682"}
{"text": "（1）行直肠癌姑息性手术、行直肠癌根治Mile’s术和直肠癌急诊手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s683"}
{"text": " 3)无符合排除标准的全身病史。", "label": 4, "label_text": "Disease", "id": "s684"}
{"text": " （6）过去12个月内使用其他免疫调节剂如胸腺肽或多价细菌疫苗治疗的患儿；", "label": 0, "label_text": "Therapy or Surgery", "id": "s685"}
{"text": " 5)有吸毒和/或酗酒史（即男性每周饮酒超过28个标准单位，女性每周饮酒超过21个标准单位【1标准单位含14g酒精，如360mL啤酒或45mL酒精量为40%的烈酒或150mL葡萄酒】）。", "label": 2, "label_text": "Addictive Behavior", "id": "s686"}
{"text": " 2.  所有受试者均为孤立型，不伴有其它系统疾病的咖啡斑患者。", "label": 4, "label_text": "Disease", "id": "s687"}
{"text": "1.既往有BCG膀胱灌注或GC方案化疗史.", "label": 0, "label_text": "Therapy or Surgery", "id": "s688"}
{"text": " （2）需要进行静脉溶栓或者血管内再通治疗，进入绿色通道", "label": 0, "label_text": "Therapy or Surgery", "id": "s689"}
{"text": " (3) 糖尿病严重并发症;", "label": 4, "label_text": "Disease", "id": "s690"}
{"text": " 2.各种原因引起的重度肺动脉高压（?脏彩超证实）", "label": 1, "label_text": "Sign", "id": "s691"}
{"text": " 3 神经或精神发育异常的患儿", "label": 4, "label_text": "Disease", "id": "s692"}
{"text": " ⑨需进行西医系统治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s693"}
{"text": " [2]年龄18-65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s694"}
{"text": " 4）严重的、未被控制的系统性疾病，如：血液系统疾病、有或曾有充血性心力衰竭病史的心室功能障碍等，或任何伴随状况研究者认为影响研究治疗和结果评估，或不能确保完成本研究；", "label": 5, "label_text": "Multiple", "id": "s695"}
{"text": " 5、严重痴呆，不能配合检查者，癫痫并正在用药治疗者，各种原因正在用?阻断剂（包括滴眼）；", "label": 5, "label_text": "Multiple", "id": "s696"}
{"text": " （3）具有子宫畸形（单角子宫、双角子宫、双子宫、未治疗的纵膈子宫）及其他影响宫腔形态疾病（子宫腺肌病、粘膜下子宫肌瘤、宫腔粘连及瘢痕子宫）的患者；", "label": 4, "label_text": "Disease", "id": "s697"}
{"text": " 2、有血栓病史者。", "label": 4, "label_text": "Disease", "id": "s698"}
{"text": " 4.职业中毒（如工业CO泄露导致）；", "label": 4, "label_text": "Disease", "id": "s699"}
{"text": " (5)实验室检查(血尿常规、肝肾功能和心电图检查)发现血液、心、肝和肾功能不全者。", "label": 5, "label_text": "Multiple", "id": "s700"}
{"text": " (2) 既往有精神疾病史", "label": 4, "label_text": "Disease", "id": "s701"}
{"text": "1. 对头孢菌素类药物过敏患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s702"}
{"text": " 6.具有难以控制的严重疾病（房颤，心绞痛，心功能不全，射血分数低于50%，肾功能不全尿蛋白检测2+以上）", "label": 5, "label_text": "Multiple", "id": "s703"}
{"text": " 2、慢性腹泻次数多于3次/日，＞1个月；", "label": 28, "label_text": "Symptom", "id": "s704"}
{"text": " 2.对局麻药和所用全身麻醉药存在或可疑过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s705"}
{"text": " 9)无法沟通或交流；", "label": 25, "label_text": "Literacy", "id": "s706"}
{"text": " （4）MRC-SS评分<48分；或入住ICU后股直肌横截面积（RFCSA）下降大于9.42%；", "label": 5, "label_text": "Multiple", "id": "s707"}
{"text": " 5)术中桡动脉穿刺失败改行股动脉路径；", "label": 0, "label_text": "Therapy or Surgery", "id": "s708"}
{"text": " 3.意识不清、不能表达主观不适症状者及精神病患者；", "label": 5, "label_text": "Multiple", "id": "s709"}
{"text": " 2）妊娠中及试验期间希望妊娠的妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s710"}
{"text": "1.年龄：18-75岁；", "label": 3, "label_text": "Age", "id": "s711"}
{"text": " （11）可疑对利多卡因过敏史。", "label": 7, "label_text": "Allergy Intolerance", "id": "s712"}
{"text": "①入组前4周曾服用可能影响研究结果的药物，如PPI、H2受体阻滞剂、铋剂、抗生素等", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s713"}
{"text": " d.总胆红素≤ 1.5×正常值上限（ULN）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s714"}
{"text": "1.年龄介于18至35周岁之间，包括18和35周岁；", "label": 3, "label_text": "Age", "id": "s715"}
{"text": " 5)预计生存期超过3月。", "label": 23, "label_text": "Life Expectancy", "id": "s716"}
{"text": " ③ 合并可能影响针刺治疗的其他疾病，如凝血障碍、白细胞减少、起搏器、癫痫，或抗凝治疗；", "label": 4, "label_text": "Disease", "id": "s717"}
{"text": " 13. 参加治疗前2 周内系统使用全身性、系统性类固醇药物者（最近或目前正在使用吸入类固醇的除外）。", "label": 4, "label_text": "Disease", "id": "s718"}
{"text": " （3）当地居民6个月以上，12月内不得有社区搬迁计划", "label": 40, "label_text": "Address", "id": "s719"}
{"text": "1. 女性,年龄 18-70 岁；", "label": 5, "label_text": "Multiple", "id": "s720"}
{"text": " 3. 体重：50 ~ 70 kg。", "label": 12, "label_text": "Laboratory Examinations", "id": "s721"}
{"text": "1. 严重心脏疾病患者；", "label": 4, "label_text": "Disease", "id": "s722"}
{"text": " （7）患者有醺酒或者药物成瘾史；", "label": 2, "label_text": "Addictive Behavior", "id": "s723"}
{"text": "（1）表现为神经根症状：臀部或下肢疼痛、麻木或运动功能障碍，伴或不伴腰痛,伴或不伴大小便功能障碍；", "label": 1, "label_text": "Sign", "id": "s724"}
{"text": " ⑦不同意参加本研究的患者", "label": 13, "label_text": "Consent", "id": "s725"}
{"text": " 3. 近半年内服用过任何明确影响血脂的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s726"}
{"text": "1  不能或不愿签知情同意书者。", "label": 13, "label_text": "Consent", "id": "s727"}
{"text": " ④ 签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s728"}
{"text": " 3.肾脏疾病史", "label": 4, "label_text": "Disease", "id": "s729"}
{"text": " 5)病情危重（术前ASA分级≥IV级者）；严重肾功能损害（术前接受透析治疗）；严重肝功能损害（Child-Pugh C级）者；术前合并严重心脏疾患，LVEF＜30%者。", "label": 5, "label_text": "Multiple", "id": "s730"}
{"text": "（1）诊断为恶性血液病的患者", "label": 4, "label_text": "Disease", "id": "s731"}
{"text": " (6) 愿意签署书面知情同意书并遵守研究方案。", "label": 13, "label_text": "Consent", "id": "s732"}
{"text": " ② 受教育年限≥6年（小学及以上）；", "label": 41, "label_text": "Education", "id": "s733"}
{"text": "  ③ 合并其他部位疼痛的患者；", "label": 28, "label_text": "Symptom", "id": "s734"}
{"text": " (3) 无高血压、糖尿病等慢性代谢疾病或合并症；", "label": 4, "label_text": "Disease", "id": "s735"}
{"text": "(1)阿德福韦酯单药治疗应答不佳接受拉米夫定（LAM）和阿德福韦酯（ADV）或替比夫定（LDT）和阿德福韦酯联合治疗至少1年后获得病毒学应答", "label": 5, "label_text": "Multiple", "id": "s736"}
{"text": " ⑥妊娠试验阳性或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s737"}
{"text": "1)年龄60-80岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s738"}
{"text": " (3)手术为脾切除+贲门周围血管离断术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s739"}
{"text": " 12）不能理解或遵从研究方案", "label": 8, "label_text": "Compliance with Protocol", "id": "s740"}
{"text": " 使用研究药物前3个月内参加过其他临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s741"}
{"text": " 2.左心射血分数<40%，左房内径>55mm", "label": 12, "label_text": "Laboratory Examinations", "id": "s742"}
{"text": " ⑥出现马鞍区麻木等马尾神经受压症状需进行手术治疗者。", "label": 5, "label_text": "Multiple", "id": "s743"}
{"text": " 4、依从性好，能够定期随访者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s744"}
{"text": " 血小板≥50×109/L，", "label": 12, "label_text": "Laboratory Examinations", "id": "s745"}
{"text": " 2)全身健康状况差", "label": 32, "label_text": "Healthy", "id": "s746"}
{"text": " 3.年龄 18-65 岁之间；", "label": 3, "label_text": "Age", "id": "s747"}
{"text": " (14)妊娠期、哺乳期女性或计划在试验期间怀孕的女性，以及在整个试验期间至试验结束后6个月内不愿采取屏障避孕措施的男性或女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s748"}
{"text": "符合《ICD-10精神与行为障碍分类》精神分裂症的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s749"}
{"text": " ⑻ 孕妇或哺乳期女性及尚未采取可靠避孕措施的育龄妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s750"}
{"text": " （2）MRI检查有脑梗死急性期、恢复期证据；", "label": 11, "label_text": "Diagnostic", "id": "s751"}
{"text": " 参照《腰椎间盘突出症》(第3版)腰椎间盘突出症的诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s752"}
{"text": " ④ 患者及委托人同意参加本研究，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s753"}
{"text": " 血常规、肝肾功能、尿常规正常（白细胞 > 3.0×109/L, 血小板 > 100×109/L, 肌酐清除率>60ml/min, 胆红素 < 1.25×上限）", "label": 12, "label_text": "Laboratory Examinations", "id": "s754"}
{"text": " 2) Karnofsky评分≥80分；", "label": 9, "label_text": "Risk Assessment", "id": "s755"}
{"text": " 年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s756"}
{"text": " ②３个月内曾经接受前列腺穿刺；", "label": 0, "label_text": "Therapy or Surgery", "id": "s757"}
{"text": " 8.合并休克及危重病患，不能配合操作及评价效果者；", "label": 4, "label_text": "Disease", "id": "s758"}
{"text": "1.年龄18-75岁，性别不限。经大肠镜诊断并经内镜摘除病理证实CRA者;", "label": 5, "label_text": "Multiple", "id": "s759"}
{"text": " 4.心功不全（纽约心脏协会分级III-IV）", "label": 6, "label_text": "Organ or Tissue Status", "id": "s760"}
{"text": " 2）严重的肝脏、肾脏、心肺损害；", "label": 4, "label_text": "Disease", "id": "s761"}
{"text": " （2）年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s762"}
{"text": "(1) 接受原位肝移植的肝病患者", "label": 5, "label_text": "Multiple", "id": "s763"}
{"text": "（1）前次促排卵巢低反应患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s764"}
{"text": "1.结核性胸膜炎组诊断需符合结核性胸膜炎诊断；恶性胸腔积液组胸腔积液有明确病理学依据", "label": 11, "label_text": "Diagnostic", "id": "s765"}
{"text": " 4.预计生存期在6个月以上者；", "label": 23, "label_text": "Life Expectancy", "id": "s766"}
{"text": " 3、近一周内服用过泻剂、止泻剂及胃肠动力药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s767"}
{"text": " 10.严重凝血功能异常者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s768"}
{"text": " 3）受试者对研究支架系统或方案要求的伴随药物过敏（如西罗莫司、噻吩并吡啶或阿司匹林；造影剂；丙烯酸；不锈钢）", "label": 7, "label_text": "Allergy Intolerance", "id": "s769"}
{"text": " （7）弥漫性泛细支气管炎；", "label": 4, "label_text": "Disease", "id": "s770"}
{"text": " 12)严重的肝、肾疾病，或血生化AST、ALT >ULN的1.5倍；Cr>ULN者；", "label": 5, "label_text": "Multiple", "id": "s771"}
{"text": " （7）日常工作生活不能避免对测试部位剧烈擦洗或者浸泡的受试者；", "label": 38, "label_text": "Nursing", "id": "s772"}
{"text": " 2、研究中运用的药物，如局部麻醉药、阿片类药物等过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s773"}
{"text": " 4)年龄18~70岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s774"}
{"text": " （4）在1个月内出现严重感染者。", "label": 4, "label_text": "Disease", "id": "s775"}
{"text": "1.高血压3级（血压>180/110mmHg）；", "label": 5, "label_text": "Multiple", "id": "s776"}
{"text": " 2.骨骼病灶有病理学检查结果", "label": 11, "label_text": "Diagnostic", "id": "s777"}
{"text": " 9)伴胸腔积液或腹水，引起呼吸道综合征(≥CTCAE 2级呼吸困难)；", "label": 5, "label_text": "Multiple", "id": "s778"}
{"text": " 4.裂隙灯检查发现睑缘有如下改变之一：", "label": 12, "label_text": "Laboratory Examinations", "id": "s779"}
{"text": " 2. 停经>3月", "label": 4, "label_text": "Disease", "id": "s780"}
{"text": " （6）需要永久口服抗凝剂（如华法林、利伐沙班、达比加群、醋酸香豆素等）治疗的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s781"}
{"text": " 8. 试验前4周内，有口服他汀类药物病史的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s782"}
{"text": "1、癫痫病史或卒中后癫痫发作史；", "label": 4, "label_text": "Disease", "id": "s783"}
{"text": "①经病理确诊乳腺癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s784"}
{"text": " 8、先天性不能耐受费瑞卡中营养素的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s785"}
{"text": " 7. 自然流产次数≥2次或胚胎移植失败≥2次；", "label": 5, "label_text": "Multiple", "id": "s786"}
{"text": " 2.明确诊断的肺动脉高压患者，肺动脉高压的诊断参照2015年欧洲心脏病学会肺动脉高压诊治指南，即在海平面状态下，静息时右心导管测量平均肺动脉压（mPAP）≥25mmHg，且肺动脉楔压（PAWP≤15mmHg）；", "label": 5, "label_text": "Multiple", "id": "s787"}
{"text": " ① 谷丙转氨酶（ALT）水平<5倍正常值上限；", "label": 12, "label_text": "Laboratory Examinations", "id": "s788"}
{"text": " 2.不进行常规分流", "label": 0, "label_text": "Therapy or Surgery", "id": "s789"}
{"text": " 2.近三周内有急性疾病及药物使用史", "label": 5, "label_text": "Multiple", "id": "s790"}
{"text": " (5) 患有不易控制的精神病史者；", "label": 4, "label_text": "Disease", "id": "s791"}
{"text": "1）尿频、尿急继发于其他疾病者（继发性膀胱过度活动症患者）；", "label": 4, "label_text": "Disease", "id": "s792"}
{"text": " 3.按照who的标准，受试者应诊断为2型糖尿病。", "label": 4, "label_text": "Disease", "id": "s793"}
{"text": " ⑦正在或最近3个月内接受试验药物治疗", "label": 15, "label_text": "Enrollment in other studies", "id": "s794"}
{"text": " 5.心功能正常（NYHA 1-2)；", "label": 5, "label_text": "Multiple", "id": "s795"}
{"text": " 肝功能损伤（ALT＞3倍正常上限或AST＞3倍正常上限）", "label": 5, "label_text": "Multiple", "id": "s796"}
{"text": " 8正在接受分子靶向药物治疗；符合皮疹诊断标准，NCI-CTCAE3.0评估1级以上者；症状持续1天以上。", "label": 5, "label_text": "Multiple", "id": "s797"}
{"text": " 2.病毒性肝炎或伴有严重肝损", "label": 4, "label_text": "Disease", "id": "s798"}
{"text": " （4）有食管、胃肠手术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s799"}
{"text": " 3. 组织病理检查确诊为前列腺腺癌;", "label": 11, "label_text": "Diagnostic", "id": "s800"}
{"text": " 7.存在可能导致患者生存期不足3个月的疾病，例如需要机械通气维持、重要脏器功能衰竭，严重、持续进展的对常规治疗无效的感染等。", "label": 5, "label_text": "Multiple", "id": "s801"}
{"text": "(1)年龄超过18岁的住院患者，性别不限；", "label": 5, "label_text": "Multiple", "id": "s802"}
{"text": " ③ 性别：男性或者女性，女性受试者必须已绝经或者使用行之有效的方法进行避孕。", "label": 5, "label_text": "Multiple", "id": "s803"}
{"text": "（1）符合慢性疲劳综合征诊断标准者（1994 CDC标准）；", "label": 11, "label_text": "Diagnostic", "id": "s804"}
{"text": " 2.术中麻醉效果欠佳的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s805"}
{"text": " 4.至少有一个可测量病灶；", "label": 4, "label_text": "Disease", "id": "s806"}
{"text": "(1) 不能进行PET/CT检查；", "label": 17, "label_text": "Capacity", "id": "s807"}
{"text": " 8.术前即有咽痛、声嘶、吞咽困难的患儿；", "label": 28, "label_text": "Symptom", "id": "s808"}
{"text": "（1）符合IBS-M、IBS-U、IBS-C罗马Ⅲ诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s809"}
{"text": " ⑸．术后有ICU病房住院病史的患者；", "label": 26, "label_text": "Encounter", "id": "s810"}
{"text": " 7）肢体肌肉力量不良等不能进行常规术后康复治疗患者", "label": 5, "label_text": "Multiple", "id": "s811"}
{"text": " 3）心功能不全或合并心肺疾病；", "label": 5, "label_text": "Multiple", "id": "s812"}
{"text": "1.40岁及40岁以上人群", "label": 3, "label_text": "Age", "id": "s813"}
{"text": " 2)有胆石症、胆道感染、十二指肠降段疾病等病史；", "label": 4, "label_text": "Disease", "id": "s814"}
{"text": " （6）预期不能在指定临床实验中心随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s815"}
{"text": " 8. 合并其他残疾；", "label": 33, "label_text": "Disabilities", "id": "s816"}
{"text": " ⑤不能按规定用药，无法判定疗效或资料不全等影响疗效判定者；", "label": 5, "label_text": "Multiple", "id": "s817"}
{"text": " 4.无定期进行尿流动力学检查者", "label": 12, "label_text": "Laboratory Examinations", "id": "s818"}
{"text": " 5.受试者自愿并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s819"}
{"text": " 2.有凹陷性痤疮瘢痕。", "label": 4, "label_text": "Disease", "id": "s820"}
{"text": " ④进展期食食管癌者。", "label": 4, "label_text": "Disease", "id": "s821"}
{"text": " (4)BMI（18.5-29.9）kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s822"}
{"text": " ?患者或家属拒绝参加该研究；", "label": 13, "label_text": "Consent", "id": "s823"}
{"text": " a)预计困难气道患者", "label": 4, "label_text": "Disease", "id": "s824"}
{"text": " （3）严重躯体疾病，如：心、肝、肾相关疾病、慢性阻塞性肺疾病、哮喘、恶性肿瘤等，以及其他危及生命情况的患者；", "label": 4, "label_text": "Disease", "id": "s825"}
{"text": " ⑥筛选前2个月内接受过全身或关节腔内的激素治疗或2个月内对膝关节进行关节镜检查；筛选前6个月内膝关节炎有创伤或者外科手术，或膝关节有3次或以上创伤或外科手术史。", "label": 0, "label_text": "Therapy or Surgery", "id": "s826"}
{"text": " ③ 伴有其它严重器质性疾病，如严重的肝肾功能衰竭、心力衰竭、脑卒中等；严重的头部损伤。", "label": 5, "label_text": "Multiple", "id": "s827"}
{"text": "①符合西医失眠的诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s828"}
{"text": " 4)有消化道溃疡合并症的患者", "label": 4, "label_text": "Disease", "id": "s829"}
{"text": " 2）药物治疗为替莫唑胺", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s830"}
{"text": " 12. 试验前3个月参加过其他临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s831"}
{"text": " 4）怀孕和哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s832"}
{"text": " 3.严重的合并症，并发症", "label": 4, "label_text": "Disease", "id": "s833"}
{"text": " （6）年龄在出生至3月龄之间", "label": 3, "label_text": "Age", "id": "s834"}
{"text": " ⑩不签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s835"}
{"text": "1、合并有12个月病史的脑血管病（脑出血、蛛网膜下腔出血、脑血栓形成、脑梗死及短暂性脑缺血发作）、3个月病史的急性冠状动脉综合征、失代偿性心力衰竭，严重肝肾功能障碍或肾病活动期。", "label": 5, "label_text": "Multiple", "id": "s836"}
{"text": " 6)年龄在35-70岁；", "label": 3, "label_text": "Age", "id": "s837"}
{"text": " 4）早孕期ALT正常", "label": 12, "label_text": "Laboratory Examinations", "id": "s838"}
{"text": " 6) 在筛选前14天内服用了任何处方药、非处方药、任何维生素产品或草药。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s839"}
{"text": " ②诊断含有膝关节肿瘤", "label": 11, "label_text": "Diagnostic", "id": "s840"}
{"text": " 4. 住院病史及影像学资料不全患者", "label": 22, "label_text": "Data Accessible", "id": "s841"}
{"text": " 2精神疾病；", "label": 4, "label_text": "Disease", "id": "s842"}
{"text": " ⑤可以进行正常的言语沟通交流。", "label": 25, "label_text": "Literacy", "id": "s843"}
{"text": "1.年龄：65-85岁", "label": 3, "label_text": "Age", "id": "s844"}
{"text": " 8) 妊娠期和哺乳期女性，或试验期间不能采取1种或以上避孕措施者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s845"}
{"text": " 注：若为双侧患者，两侧均进行修复，均进行评估。", "label": 5, "label_text": "Multiple", "id": "s846"}
{"text": " ASA分级I~II级；18y≤age≤75y", "label": 5, "label_text": "Multiple", "id": "s847"}
{"text": " 2.不符合样本采集和处理要求的样本，及经过靶向治疗过基因突变的样本；", "label": 29, "label_text": "Receptor Status", "id": "s848"}
{"text": " 6严重心肺疾病患者（如严重心律失常、心室率缓慢者（心室率<50次/分）、心机梗死急性期及重度心力衰竭）、凝血机制障碍（凝血指标>正常上限的1.5倍）、败血症及其他不适合者；", "label": 4, "label_text": "Disease", "id": "s849"}
{"text": "(1)对碘克沙醇有禁忌症的患者（例如明显的甲状腺毒症和对含碘对比剂有严重超敏反应病史）。", "label": 7, "label_text": "Allergy Intolerance", "id": "s850"}
{"text": " （4）同意参加临床调查并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s851"}
{"text": " 6.有门静脉癌栓或有肝外转移", "label": 4, "label_text": "Disease", "id": "s852"}
{"text": " (5)研究人员认为其他原因不适合临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s853"}
{"text": "1.年龄：年龄在18至65周岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s854"}
{"text": " 7 试验依从性较差或试验过程中失访的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s855"}
{"text": " （6）300g/L<阻塞性脂蛋白X（LP-X）<800g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s856"}
{"text": " 预计无法完成随访的患者", "label": 8, "label_text": "Compliance with Protocol", "id": "s857"}
{"text": " （4）依从性差、不能配合听力检查的患者", "label": 8, "label_text": "Compliance with Protocol", "id": "s858"}
{"text": " 5.可能对免疫治疗过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s859"}
{"text": " （3）所有入选患者均为生活基本自理，以前未接受过系统吞咽功能及嗓音功能评估；", "label": 5, "label_text": "Multiple", "id": "s860"}
{"text": " 3,肝功能障碍（转氨酶超过正常值上限1.5倍），肾功能障碍（Cr>2.0mg/dl或177μmol/L）或患有其他严重的全身性疾病者等；", "label": 5, "label_text": "Multiple", "id": "s861"}
{"text": " 5、达到痴呆的诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s862"}
{"text": " 2.正在怀孕或哺乳，或哺乳结束后3个月以内。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s863"}
{"text": " 14.研究者认为不适合入组的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s864"}
{"text": " 2)生化检查需符合以下标准：TBIL＜1.5×ULN， ALT、AST＜2.5×ULN有肝转移受试者可＜5×ULN，BUN和Cr≤1×ULN或内生肌酐清除率≥50ml/min（Cockcroft-Gault公式）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s865"}
{"text": " 2)男性受试者体重不低于50 公斤。体重指数（BMI）＝体重（kg）/身高2（m2），体重指数在18~28范围内（包括临界值）；", "label": 5, "label_text": "Multiple", "id": "s866"}
{"text": " (2)年龄在18～40周岁，同一批受试者年龄不相差10岁；", "label": 3, "label_text": "Age", "id": "s867"}
{"text": " 9)在服用研究药物前28 天服用了任何改变肝酶活性的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s868"}
{"text": "（1）根据世界神经病学联合会标准，被诊断为家族性或偶发性的ALS的参与者；", "label": 11, "label_text": "Diagnostic", "id": "s869"}
{"text": " ②重型颅脑损伤需手术治疗的患者（GCS3-8分）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s870"}
{"text": " 4）由于个人原因无法依从本研究", "label": 8, "label_text": "Compliance with Protocol", "id": "s871"}
{"text": "①由其他疾病如遗传、内分泌、代谢及中枢神经系统疾病引起的肥胖及肥胖综合征。", "label": 4, "label_text": "Disease", "id": "s872"}
{"text": " 12）现患恶性肿瘤或既往恶性肿瘤史", "label": 4, "label_text": "Disease", "id": "s873"}
{"text": " ⑥法律规定的残疾患者（盲，聋，哑，智力障碍，精神障碍，肢体残疾）；", "label": 33, "label_text": "Disabilities", "id": "s874"}
{"text": " 7.眼压正常（不大于21mmHg）", "label": 12, "label_text": "Laboratory Examinations", "id": "s875"}
{"text": " ⑥3月内未服用羟苯磺酸钙。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s876"}
{"text": " 已知的凝血障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s877"}
{"text": " （7）心律失常。", "label": 4, "label_text": "Disease", "id": "s878"}
{"text": "①严重心脏病、心律失常及高血压患者，年老体弱，全身情况很差，或有严重内科疾病如心、肺、肝、肾等重要脏器功能障碍及肿瘤等；", "label": 5, "label_text": "Multiple", "id": "s879"}
{"text": " 3.有高血压、糖尿病、肝硬化或冠心病等系统疾病。", "label": 4, "label_text": "Disease", "id": "s880"}
{"text": " 5）血肌酐3mg/dL以上的患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s881"}
{"text": " 2.年龄≥18周岁", "label": 3, "label_text": "Age", "id": "s882"}
{"text": " 8、有活动性出血或出血危险性高(凝血酶原活动度<60%，血小板<100×109/L)者。比如：既往有血液系统疾病、凝血功能障碍异常、消化性溃疡、出血性胃炎、食管静脉曲张、近期有手术史、近期有活动性出血等；", "label": 5, "label_text": "Multiple", "id": "s883"}
{"text": "（1）患者拒绝参加本研究。", "label": 13, "label_text": "Consent", "id": "s884"}
{"text": " 4.患有高血压且经降压药物治疗无法降至正常范围内者（收缩压>140 mmHg，舒张压>90 mmHg）；", "label": 5, "label_text": "Multiple", "id": "s885"}
{"text": " g)妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s886"}
{"text": " 4.在过去一个月内没用过抗炎的药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s887"}
{"text": " ②年龄18-80岁；", "label": 3, "label_text": "Age", "id": "s888"}
{"text": " 3.有严重的心、肝、肺、肾、血液及内分泌等疾病", "label": 4, "label_text": "Disease", "id": "s889"}
{"text": " ●白血病、淋巴瘤、再生障碍性贫血等严重的血液病", "label": 4, "label_text": "Disease", "id": "s890"}
{"text": " (2)年龄在30-65岁之间者；", "label": 3, "label_text": "Age", "id": "s891"}
{"text": " 2.性激素异常：行性激素检查有异常。", "label": 12, "label_text": "Laboratory Examinations", "id": "s892"}
{"text": " ③影像学诊断为椎间盘脱垂、影像或临床有马尾神经受压者；", "label": 11, "label_text": "Diagnostic", "id": "s893"}
{"text": " 4．合并有未控制的泌尿系感染导致膀胱尿道功能障碍；", "label": 5, "label_text": "Multiple", "id": "s894"}
{"text": " 过去12个月内有中风、心肌梗死、心绞痛、冠状动脉旁路移植术或经皮腔内冠状动脉成形术史", "label": 5, "label_text": "Multiple", "id": "s895"}
{"text": " ⑿签署知情同意书，依从性好，可随访者。", "label": 5, "label_text": "Multiple", "id": "s896"}
{"text": " 2.近期无药物、射线和营养补充剂的接触史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s897"}
{"text": " ⑦患者侧上肢Brunnstrom分期I-III期；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s898"}
{"text": " c)参加定期的访视，并且愿意接受电话随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s899"}
{"text": " 7)妊娠或准备妊娠妇女，哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s900"}
{"text": " 2.经宫腔子宫内膜息肉电切术禁忌症者", "label": 4, "label_text": "Disease", "id": "s901"}
{"text": " 5）肝肾功能明显异常，超出入组标准;", "label": 6, "label_text": "Organ or Tissue Status", "id": "s902"}
{"text": " (4)年龄18～65岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s903"}
{"text": " 3）类风湿性关节炎、化脓性关节炎等关节疾病", "label": 4, "label_text": "Disease", "id": "s904"}
{"text": " 8.使用免疫抑制剂治疗者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s905"}
{"text": " 18.急性出血倾向，包括血小板计数低于100× 109/L或其他情况。", "label": 5, "label_text": "Multiple", "id": "s906"}
{"text": "1. 年龄> 65 岁", "label": 3, "label_text": "Age", "id": "s907"}
{"text": "1.符合小儿反复呼吸道感染西医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s908"}
{"text": " 3.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s909"}
{"text": " ⑦认知功能障碍或无法用言语准确沟通；", "label": 5, "label_text": "Multiple", "id": "s910"}
{"text": "1. 复治患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s911"}
{"text": " 8. 颈部或面部外伤灼伤或上气道出血或阻塞;", "label": 4, "label_text": "Disease", "id": "s912"}
{"text": " ⑽ 4周内参加过其它药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s913"}
{"text": "1）交流障碍、无法配合研究者，如语言理解障碍、精神疾病等；", "label": 5, "label_text": "Multiple", "id": "s914"}
{"text": " 3、入院时已发生严重消化道出血、有慢性胃肠道疾病或曾经行胃肠道手术治疗；", "label": 4, "label_text": "Disease", "id": "s915"}
{"text": " 2)在参加本试验前3个月曾接受过其他研究药物。", "label": 15, "label_text": "Enrollment in other studies", "id": "s916"}
{"text": " ③简易精神状态量表（mini-mental state examination, MMSE）评分≥20分；", "label": 9, "label_text": "Risk Assessment", "id": "s917"}
{"text": " （6）肥胖BMI>35", "label": 9, "label_text": "Risk Assessment", "id": "s918"}
{"text": "  1) 年龄18～40岁（包括18岁和40岁），男女不限；", "label": 5, "label_text": "Multiple", "id": "s919"}
{"text": " 8）严重钙化需要旋磨治疗", "label": 5, "label_text": "Multiple", "id": "s920"}
{"text": " 7.溃疡并见肌腱、骨骼暴露者；", "label": 4, "label_text": "Disease", "id": "s921"}
{"text": " 视力≥20/100，近视度数≤-6D；", "label": 12, "label_text": "Laboratory Examinations", "id": "s922"}
{"text": " 2) 膝关节软骨缺损面积≥2cm2且≤8cm2，可行微骨折术的患者，无手术禁忌症", "label": 5, "label_text": "Multiple", "id": "s923"}
{"text": " 6. 严重肝肾功能不全者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s924"}
{"text": "（1）特发性黄斑孔及创伤性黄斑孔导致的视网膜脱离；", "label": 4, "label_text": "Disease", "id": "s925"}
{"text": " (6) 患牙周围牙槽骨骨量充足，可行常规早期或延期种植，不需行ARP；", "label": 0, "label_text": "Therapy or Surgery", "id": "s926"}
{"text": " 14） 试验前3个月内曾献血或失血≥400 ml者、接受输血或使用血制品者；", "label": 5, "label_text": "Multiple", "id": "s927"}
{"text": "⑴ 择期在CPB下行心脏瓣膜置换或冠脉搭桥或先心手术患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s928"}
{"text": " 10.患者自愿签署知情同意书", "label": 13, "label_text": "Consent", "id": "s929"}
{"text": " 3)单个肿瘤直径>1cm或膀胱肿瘤为多发；", "label": 24, "label_text": "Neoplasm Status", "id": "s930"}
{"text": " ③发病后三周（加减一周），其它神经功能稳定者。", "label": 4, "label_text": "Disease", "id": "s931"}
{"text": " 4.咽痛VAS评分≥5；且咽痛中医主症评分≥6；", "label": 9, "label_text": "Risk Assessment", "id": "s932"}
{"text": " 肝肾功能正常，无合并糖尿病。", "label": 5, "label_text": "Multiple", "id": "s933"}
{"text": " 4. 单节段融合修复；", "label": 0, "label_text": "Therapy or Surgery", "id": "s934"}
{"text": "(1)年龄<18岁；", "label": 3, "label_text": "Age", "id": "s935"}
{"text": " (3)体重指数〔BMI=体重(kg)/身高(m)2〕在19~25kg/m2范围内；", "label": 9, "label_text": "Risk Assessment", "id": "s936"}
{"text": " 5. BMI为16～25kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s937"}
{"text": " 11. 未经控制的内分泌腺体功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s938"}
{"text": " e.3个月内服用过抗抑郁剂药物或其他有口干副作用的药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s939"}
{"text": " 6)根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，或生活地经常发生变动等易造成失访的情况。", "label": 5, "label_text": "Multiple", "id": "s940"}
{"text": " 7.有妊娠可能但未采取充分措施避孕者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s941"}
{"text": " 7.30天前有过颅内动脉支架或血管成形术或者颈动脉、椎动脉颅外段有过内膜切除术史的；", "label": 0, "label_text": "Therapy or Surgery", "id": "s942"}
{"text": " 2、IHC检测Her2-、+、++（FISH证实无扩增）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s943"}
{"text": " （4）近1个月内有呼吸道急性感染史。", "label": 4, "label_text": "Disease", "id": "s944"}
{"text": " 节段型血管瘤（PHASE综合征除外）", "label": 4, "label_text": "Disease", "id": "s945"}
{"text": " ②肝脏恶性肿瘤肝移植术后的病人；", "label": 5, "label_text": "Multiple", "id": "s946"}
{"text": "1、溶血危象患者：贫血进展迅速且严重，危机生命者；", "label": 5, "label_text": "Multiple", "id": "s947"}
{"text": "（1）孕妇，哺乳期和可能妊娠的妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s948"}
{"text": " 9、实验室检查指标不合格：", "label": 12, "label_text": "Laboratory Examinations", "id": "s949"}
{"text": " 7)肝肾功能正常：ALT/AST＜正常值上限(ULN)的2.5倍、总胆红素＜1.5×ULN；血清肌酐< 1.5×ULN；", "label": 5, "label_text": "Multiple", "id": "s950"}
{"text": " 2.有精神异常的病人", "label": 4, "label_text": "Disease", "id": "s951"}
{"text": " （6）合并其他影响康复的疾病者；", "label": 4, "label_text": "Disease", "id": "s952"}
{"text": " 2）根据术前肠镜活检病理结果，证实为直肠癌；", "label": 11, "label_text": "Diagnostic", "id": "s953"}
{"text": " 4)虹膜新生血管或新生血管性青光眼", "label": 4, "label_text": "Disease", "id": "s954"}
{"text": "    c）急性/慢性尿路感染，阴道感染和肛周感染的患者;", "label": 4, "label_text": "Disease", "id": "s955"}
{"text": " （2）产妇存在硬膜外麻醉禁忌症：中枢系统疾病（如脑膜炎、结核、肿瘤等），脊柱畸形，穿刺部位感染、败血症，心血管功能不全（如严重贫血、休克、心力衰竭、冠心病等），凝血功能障碍（血小板低于80*109/L，PT超过正常值3秒，TT超过正常值5秒，APTT超过正常值10秒）；", "label": 5, "label_text": "Multiple", "id": "s956"}
{"text": " 7. 受者为孕妇或哺乳期妇女，或有精神疾病。", "label": 5, "label_text": "Multiple", "id": "s957"}
{"text": "1.对爱多康有不良反应", "label": 4, "label_text": "Disease", "id": "s958"}
{"text": " 3）初次美妥昔单抗皮试阳性患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s959"}
{"text": "(1)藏族；", "label": 31, "label_text": "Ethnicity", "id": "s960"}
{"text": "1. 既往已发现AF或房扑病史，经检查（体表12导联ECG，遥测设备，动态ECG）确认有持续≥5 min AF或房扑发作；", "label": 5, "label_text": "Multiple", "id": "s961"}
{"text": " （6）妊娠或哺乳妇女，或在接受治疗过程中准备妊娠者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s962"}
{"text": "1）不孕时间≥1年", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s963"}
{"text": " 7)主管医生认为不能依从研究方案者。", "label": 21, "label_text": "Researcher Decision", "id": "s964"}
{"text": " ④近两周无感染病史；", "label": 4, "label_text": "Disease", "id": "s965"}
{"text": " 13)支气管哮喘或严重COPD患者；", "label": 4, "label_text": "Disease", "id": "s966"}
{"text": " （2）近4周病情稳定，无急性加重；", "label": 28, "label_text": "Symptom", "id": "s967"}
{"text": " 3)Karnofsky评分≥70分，ECOG PS评分0-2;", "label": 9, "label_text": "Risk Assessment", "id": "s968"}
{"text": "横断面调查：60岁及以上者；在目标社区居住至少一年及其以上者；具有正常交流能力者；自愿参加本研究者。", "label": 5, "label_text": "Multiple", "id": "s969"}
{"text": " 6)宫口扩张：2-4cm", "label": 12, "label_text": "Laboratory Examinations", "id": "s970"}
{"text": " （6）合并严重呼吸功能不全（PO2<60mmHg,即8.0Kpa；或PCO2>50 mmHg ,即6.5Kpa）", "label": 5, "label_text": "Multiple", "id": "s971"}
{"text": " （2）纳入山东济南及周边德州、聊城、济宁、菏泽、淄博、泰安、莱芜内陆地区的3-14周岁儿童哮喘患者。", "label": 5, "label_text": "Multiple", "id": "s972"}
{"text": " 3，患者有慢性疼痛症状病史；", "label": 4, "label_text": "Disease", "id": "s973"}
{"text": " ②接受椎管麻醉，美国麻醉医师协会（ASA）病情分级为I-II级；", "label": 9, "label_text": "Risk Assessment", "id": "s974"}
{"text": " iii．病理诊断无银屑病，无角质上皮过度增生，无角质上皮过度角化或伴角化不全，真皮无淋巴细胞浸润。", "label": 11, "label_text": "Diagnostic", "id": "s975"}
{"text": " (3)患者意识清楚，能配合完成该项研究；", "label": 17, "label_text": "Capacity", "id": "s976"}
{"text": " 治疗前接受过其它治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s977"}
{"text": " 3.自愿参加本次实验并有较好的依从性，能够遵守医嘱自觉服药，能按能按时复诊。", "label": 8, "label_text": "Compliance with Protocol", "id": "s978"}
{"text": " b.胃溃疡、胃出血、糖尿病或其他自身免疫性疾病、高血压未控制、结核、精神类疾病患者、青光眼、糖尿病、HIV感染或AIDS患者；", "label": 4, "label_text": "Disease", "id": "s979"}
{"text": " 2)复发性恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s980"}
{"text": " (5)婴儿具有良好的健康状况；", "label": 32, "label_text": "Healthy", "id": "s981"}
{"text": "①无法依从研究方案或研究程序；", "label": 8, "label_text": "Compliance with Protocol", "id": "s982"}
{"text": " （4）幽闭恐惧症患者。", "label": 4, "label_text": "Disease", "id": "s983"}
{"text": " (3) 不能耐受远程心电监测和植入性心电事件记录仪；", "label": 8, "label_text": "Compliance with Protocol", "id": "s984"}
{"text": " 13.患有不易控制的精神病史者；", "label": 4, "label_text": "Disease", "id": "s985"}
{"text": " 14) 研究者本人及其家庭成员。", "label": 26, "label_text": "Encounter", "id": "s986"}
{"text": " 5. 患者能够理解并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s987"}
{"text": " 3、病情稳定，意识清晰", "label": 1, "label_text": "Sign", "id": "s988"}
{"text": " 7）再次肝移植。", "label": 0, "label_text": "Therapy or Surgery", "id": "s989"}
{"text": " (9) 妊娠，近期计划生育的男性或女性，哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s990"}
{"text": "1. 合并有心血管、脑血管、肝、肾和造血系统等严重全身性疾病及精神病患者；", "label": 4, "label_text": "Disease", "id": "s991"}
{"text": " 3.阳性与阴性症状评定量表（PANSS）评分≥70分", "label": 9, "label_text": "Risk Assessment", "id": "s992"}
{"text": "年龄在14岁至65岁（含14岁及65岁）；", "label": 3, "label_text": "Age", "id": "s993"}
{"text": " （6）脾胃虚寒出现泄泻者；", "label": 11, "label_text": "Diagnostic", "id": "s994"}
{"text": " 13. 控制不良的重度高血压，即收缩压≥180mmHg和/或舒张压≥110mmHg；收缩压<95mmHg的患者。", "label": 5, "label_text": "Multiple", "id": "s995"}
{"text": " (7)有据研究者判断可能干扰试验结果或增加患者风险的任何病史；", "label": 21, "label_text": "Researcher Decision", "id": "s996"}
{"text": " 6.患儿年龄较小，不会使用峰流速仪者。", "label": 5, "label_text": "Multiple", "id": "s997"}
{"text": " 2）年龄20~40岁", "label": 3, "label_text": "Age", "id": "s998"}
{"text": " 2. 神经源性膀胱；", "label": 4, "label_text": "Disease", "id": "s999"}
{"text": " 6.不明原因阴道流血；", "label": 1, "label_text": "Sign", "id": "s1000"}
{"text": " 15)处于哺乳期或妊娠期妇女者；（问诊）", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1001"}
{"text": " ③ 肌钙蛋白升高URL99百分位值；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1002"}
{"text": " 6.正在或3个月内服用过抗凝药物的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1003"}
{"text": " （6）母亲孕期检查数据可得；", "label": 22, "label_text": "Data Accessible", "id": "s1004"}
{"text": " 3、能够采取手术切除或活检取得新鲜的肿瘤组织样本；", "label": 29, "label_text": "Receptor Status", "id": "s1005"}
{"text": " 10.尿蛋白阳性的患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1006"}
{"text": " (10) 就诊前3天内有服用过其他止咳药物的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1007"}
{"text": " 3.患者依从性好，理解并且同意穴位埋线", "label": 8, "label_text": "Compliance with Protocol", "id": "s1008"}
{"text": " 10)入组前存在甲状腺功能异常或正接受激素治疗；", "label": 5, "label_text": "Multiple", "id": "s1009"}
{"text": " 6)肿瘤标志物检测未见明显异常，或经研究者判断受试者没有肿瘤发生的风险；", "label": 5, "label_text": "Multiple", "id": "s1010"}
{"text": " 2. 能够承受骨髓穿刺检查", "label": 17, "label_text": "Capacity", "id": "s1011"}
{"text": " (6)研究者认为不适合参加试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s1012"}
{"text": " ③ 多囊卵巢患者；", "label": 4, "label_text": "Disease", "id": "s1013"}
{"text": " 19.目前正在使用凝血酶抑制剂或Ⅹa因子抑制剂，各种敏感的实验室检查异常（如APTT、INR、血小板计数、ECT；TT或恰当的Ⅹa因子活性测定等）。", "label": 5, "label_text": "Multiple", "id": "s1014"}
{"text": " ③椎管内麻醉禁忌者", "label": 4, "label_text": "Disease", "id": "s1015"}
{"text": " 7）体格检查、生命体征正常或异常无临床意义。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1016"}
{"text": " 4、自愿加入实验并签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s1017"}
{"text": " 5.无血液系统疾病，入组前WBC > 4×109/L，PLT > 100×109/L，HGB> 80g/L；肝功能（ALT、AST≤正常值上限×2.5倍）；双侧肾功能均正常：肌酐清除率> 60 ml/min；", "label": 5, "label_text": "Multiple", "id": "s1018"}
{"text": " （5）预计在一周内将要出院的新生儿；", "label": 5, "label_text": "Multiple", "id": "s1019"}
{"text": "（1）肝脏、肺、骨等远处转移", "label": 24, "label_text": "Neoplasm Status", "id": "s1020"}
{"text": " （2）全身功能状态评分（ECOG）为0-2分", "label": 9, "label_text": "Risk Assessment", "id": "s1021"}
{"text": "1. 年龄40～70周岁（包括40，70周岁）门诊COPD患者，性别不限；", "label": 5, "label_text": "Multiple", "id": "s1022"}
{"text": " (12)对干扰素及聚乙二醇过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1023"}
{"text": " （2）增值性视网膜病变", "label": 4, "label_text": "Disease", "id": "s1024"}
{"text": " ④ 无法服用中药或对中药过敏的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s1025"}
{"text": " (3)妊娠；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1026"}
{"text": " 3)头皮肿块作为对照。", "label": 4, "label_text": "Disease", "id": "s1027"}
{"text": " 4. 被诊断为癌性疼痛的患者", "label": 4, "label_text": "Disease", "id": "s1028"}
{"text": " b. 懷疑惑已證實有血栓性疾病者（如心肌梗塞、腦血管栓塞、深層靜脈栓塞、或肺栓塞等）。", "label": 4, "label_text": "Disease", "id": "s1029"}
{"text": " ⑤愿意参加本研究。", "label": 13, "label_text": "Consent", "id": "s1030"}
{"text": " (2) 前房角开放；", "label": 1, "label_text": "Sign", "id": "s1031"}
{"text": " ⑤受试者或其家属能够充分理解该疗法并且签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s1032"}
{"text": "1.已婚中老年男性受试者，年龄40~70周岁；", "label": 5, "label_text": "Multiple", "id": "s1033"}
{"text": "1.年龄小于40岁，体重指数（BMI）18-30kg/m2；", "label": 5, "label_text": "Multiple", "id": "s1034"}
{"text": " 6、术中全入肝血流阻断时间少于30分钟，或大于90分钟；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1035"}
{"text": " 10.试验前两周内，曾发生急性呼吸道感染、中耳炎或鼻窦炎的患者；", "label": 4, "label_text": "Disease", "id": "s1036"}
{"text": " （10）肝性脑病；", "label": 4, "label_text": "Disease", "id": "s1037"}
{"text": " 3、临床分期中ⅢB期的T4中（有广泛的肺外侵犯如纵膈、心脏、大血管、气管、食管、椎体、隆突、和恶性胸腔、心包积液）的患者，渗出性胸腔积液（即使细胞学为阴性患者）。X线上无法检测的微量胸腔积液可除外。", "label": 5, "label_text": "Multiple", "id": "s1038"}
{"text": "(1)年龄40-70岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1039"}
{"text": " 8.严重的肾功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1040"}
{"text": " 3）心功能不全或合并心肺疾病；", "label": 5, "label_text": "Multiple", "id": "s1041"}
{"text": " 3）病理诊断为肺癌、胃癌、肝细胞癌、胰腺癌、结直肠癌、乳腺癌等；", "label": 4, "label_text": "Disease", "id": "s1042"}
{"text": "1）拒绝参加本研究；", "label": 13, "label_text": "Consent", "id": "s1043"}
{"text": " （3）导入期和基线期测量空腹LDL-C≥4.14mmol/L，TC≥6.22mmol/L、TG≥2.26mmol/L，且两次差值不超过12%；三者满足其一即可；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1044"}
{"text": " （2）入组前发生远处淋巴结转移（腹腔第8组、13组、14组、16组淋巴结）；", "label": 24, "label_text": "Neoplasm Status", "id": "s1045"}
{"text": "1、疾病中晚期，预期生存寿命<12月；", "label": 5, "label_text": "Multiple", "id": "s1046"}
{"text": " (10) 曾接受胃，結腸或直腸切除術", "label": 0, "label_text": "Therapy or Surgery", "id": "s1047"}
{"text": " 4.乙肝或丙肝患者或携带者", "label": 4, "label_text": "Disease", "id": "s1048"}
{"text": " ⑥虽有头痛，但作为其他病的症状表现，如高血压、脑外伤综合征及颅内器质性病变等；", "label": 5, "label_text": "Multiple", "id": "s1049"}
{"text": "1.入组前曾接种过水痘减毒活疫苗，或既往有水痘、带状疱疹病毒感染发病史者", "label": 5, "label_text": "Multiple", "id": "s1050"}
{"text": "（1）、BMI<25Kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s1051"}
{"text": "①根据HRS/EHRA/ECAS 2007房颤指南，经心电图或Holter证实的房颤患者（包括持续性房颤和阵发性房颤）；", "label": 11, "label_text": "Diagnostic", "id": "s1052"}
{"text": "①20 ≤ 年龄 ≤ 70 岁", "label": 3, "label_text": "Age", "id": "s1053"}
{"text": " 6.近期或者长期使用抗凝或者抗血小板聚集的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1054"}
{"text": " 3.能够采取手术切除或活检取得新鲜的肿瘤组织样本；", "label": 29, "label_text": "Receptor Status", "id": "s1055"}
{"text": "1. 18岁以上，初次妊娠或产后42天的女性；", "label": 5, "label_text": "Multiple", "id": "s1056"}
{"text": " 10.酗酒者以及药物滥用及成瘾者。", "label": 2, "label_text": "Addictive Behavior", "id": "s1057"}
{"text": " 3）研究者根据临床判断依从性不好，或不配合观察治疗，拒绝签署同意书者。", "label": 5, "label_text": "Multiple", "id": "s1058"}
{"text": " ②年龄20～60岁", "label": 3, "label_text": "Age", "id": "s1059"}
{"text": " 6.已知对该类药物过敏者及过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s1060"}
{"text": " （3）志愿入选合作，并签知情同意书，同意坚持治疗中途不间断者。", "label": 13, "label_text": "Consent", "id": "s1061"}
{"text": " 7、其它研究者认为不适合入选的情况；", "label": 21, "label_text": "Researcher Decision", "id": "s1062"}
{"text": " e)有光引发的癫痫病。", "label": 4, "label_text": "Disease", "id": "s1063"}
{"text": " 3.因有症状的胸腔积液反复住院进行对症处理者，只收集本年度第一次住院的资料。", "label": 5, "label_text": "Multiple", "id": "s1064"}
{"text": "1 有缺血性卒中导致的神经功能缺损症状", "label": 5, "label_text": "Multiple", "id": "s1065"}
{"text": " （4）未接受过防跌倒训练者。", "label": 27, "label_text": "Exercise", "id": "s1066"}
{"text": " 5.研究者判断不适合参加本临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s1067"}
{"text": " 3、未使用任何西药降压药者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1068"}
{"text": " 2.传染病患者，例如艾滋病、结核病患者", "label": 4, "label_text": "Disease", "id": "s1069"}
{"text": " （1）临床已确诊患帕金森病；", "label": 11, "label_text": "Diagnostic", "id": "s1070"}
{"text": " ⑥凝血功能障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1071"}
{"text": " 20）正参加其它临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1072"}
{"text": " 2.2.iRBD组：（1）有神经系统病变者，既往有脑炎、脑外伤、癫痫、变性疾病等神经精神疾病病史，神经影像学检查有异常者；（2）目前正在有规律服用安眠药或抗精神病药物的患者，仍在使用镇静催眠类药物或酒精助眠1周内不能撤退者；（3）存在未解决的重大生活事件和心理冲突；（4）PSG检查不能合作者或PSG中，整晚睡眠无REM期者；（5）不能完成量表评估者；（6）未自愿签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s1073"}
{"text": " 2.造影图像质量较差，无法完成QFR及虚拟支架评估；", "label": 22, "label_text": "Data Accessible", "id": "s1074"}
{"text": " ⑶ 脑出血、蛛网膜下腔出血、短暂性脑缺血发作（TIA）；", "label": 4, "label_text": "Disease", "id": "s1075"}
{"text": " 6.对本试验知情同意的志愿受试者。", "label": 13, "label_text": "Consent", "id": "s1076"}
{"text": " 10、心电图检查严重心律失常者", "label": 11, "label_text": "Diagnostic", "id": "s1077"}
{"text": " 研究者认为不适合参加本研究的其他任何疾病。", "label": 21, "label_text": "Researcher Decision", "id": "s1078"}
{"text": " 2.年龄18～60岁之间，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1079"}
{"text": " （2）术前影像学提示肿瘤直径≤4cm；", "label": 11, "label_text": "Diagnostic", "id": "s1080"}
{"text": " 7）门脉系统完全血栓或海绵样变性", "label": 4, "label_text": "Disease", "id": "s1081"}
{"text": "1.年龄：18~75岁；", "label": 3, "label_text": "Age", "id": "s1082"}
{"text": " 5.研究开始前2周内使用过减少尿酸代谢或排泄的药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1083"}
{"text": " （2）以往或同时患有其他恶性肿瘤，但是已治愈的皮肤基底细胞癌和宫颈原位癌除外；", "label": 4, "label_text": "Disease", "id": "s1084"}
{"text": " 2)年龄≤42岁；", "label": 3, "label_text": "Age", "id": "s1085"}
{"text": " （6）除中药清肠温中方治疗或口服美沙拉秦治疗外，还在进行其它溃疡性结肠炎治疗方案的患者；", "label": 5, "label_text": "Multiple", "id": "s1086"}
{"text": " （2）经病理学确诊为非鳞晚期非小细胞肺癌，且胸腔积液脱落细胞学检查发现有肿瘤细胞的患者；", "label": 11, "label_text": "Diagnostic", "id": "s1087"}
{"text": " 4. 体温≥38.0℃。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1088"}
{"text": "（1）术前诊断为肝脏恶性肿瘤，术后病理学确诊系HCC；", "label": 4, "label_text": "Disease", "id": "s1089"}
{"text": " 4. 任何有临床意义的主要器官或全身性急性疾病、或任何其他情况，研究者判定难以完成随访者；", "label": 5, "label_text": "Multiple", "id": "s1090"}
{"text": " 3. 伴有吞咽困难、完全或不全消化道梗阻、消化道活动性出血、穿孔等使用化疗药物禁忌者。", "label": 5, "label_text": "Multiple", "id": "s1091"}
{"text": " 4，血小板计数<100,000/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1092"}
{"text": " ④汉密顿焦虑量表（HAMA）≥14分, 汉密顿抑郁量表HAMD(17项)≤17分", "label": 9, "label_text": "Risk Assessment", "id": "s1093"}
{"text": " （5）妊娠期、哺乳期的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1094"}
{"text": " 7)无严重的过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1095"}
{"text": " 2,患者拒绝参与研究", "label": 13, "label_text": "Consent", "id": "s1096"}
{"text": " 5）术中静脉滴注异丙肾上腺素或阿托品诱发出室速/室早患者。", "label": 5, "label_text": "Multiple", "id": "s1097"}
{"text": " 10、三个月内进行其他临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1098"}
{"text": " e)合并有严重的高血压，且经正规治疗1周后血压仍高于180/110mmhg 、房颤、不稳定性心绞痛、严重肺部感染、严重心肾功能衰竭、重症糖尿病者；", "label": 5, "label_text": "Multiple", "id": "s1099"}
{"text": "（1）年龄：儿童18个月--36个月，青少年12--16岁", "label": 5, "label_text": "Multiple", "id": "s1100"}
{"text": " 3. 有未来生育意愿的男性患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1101"}
{"text": "①就诊者目前正在吸烟，且每日均会吸烟，烟量≥10支/日；", "label": 36, "label_text": "Smoking Status", "id": "s1102"}
{"text": "①年龄≥18岁。", "label": 3, "label_text": "Age", "id": "s1103"}
{"text": " (5)合并有心脑血管、肝脏、肾脏、造血系统等严重原发性疾病，或精神病患者。", "label": 4, "label_text": "Disease", "id": "s1104"}
{"text": " 4）出生时母亲HBsAg阳性者（以出生记录卡为准）。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1105"}
{"text": " 7. 超声显示宫腔正常。", "label": 11, "label_text": "Diagnostic", "id": "s1106"}
{"text": " （2）符合美国风湿病协会(1982)修订的SLE诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s1107"}
{"text": " 1）具有癫痫病史或其他中枢神经系统疾病者；", "label": 4, "label_text": "Disease", "id": "s1108"}
{"text": "1.一周内曾口服抗组胺类药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1109"}
{"text": " 9.严重的或不能控制的精神疾病患者", "label": 4, "label_text": "Disease", "id": "s1110"}
{"text": " （2） 经传统药物治疗（如使用稳定剂量的NSAIDs治疗1个月、口服糖皮质激素或DMARD药物治疗3个月）仍属活动期AS者；", "label": 5, "label_text": "Multiple", "id": "s1111"}
{"text": " 5、PS评分0-3分；", "label": 9, "label_text": "Risk Assessment", "id": "s1112"}
{"text": "1.肝脏内单一病灶最大径≤1cm，多发病灶最大径之和≤3cm", "label": 12, "label_text": "Laboratory Examinations", "id": "s1113"}
{"text": " ③呼吸频率>20次/分或动脉血PaCO2<32 mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1114"}
{"text": " （10）正在服用营养保健品的受试者在试验期间应当维持原食用习惯，并且和研究中心说明；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1115"}
{"text": "1）患者年龄20-70岁", "label": 3, "label_text": "Age", "id": "s1116"}
{"text": "  5.年满18岁。", "label": 3, "label_text": "Age", "id": "s1117"}
{"text": "1.经过子宫内膜癌全面分期手术确诊的Ⅰ期子宫内膜癌病例，病理类型为子宫内膜样腺癌。", "label": 11, "label_text": "Diagnostic", "id": "s1118"}
{"text": " (3) 有不稳定的或快速进展性肾脏病史；", "label": 4, "label_text": "Disease", "id": "s1119"}
{"text": " 5.发病后经过溶栓、支架手术治疗者或即将开展动静脉溶栓，介入或支架手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1120"}
{"text": " 2、严重AIHA：当Hb<40g/L或Hct<0.13，但溶血较为稳定、暂不危及生命者；", "label": 5, "label_text": "Multiple", "id": "s1121"}
{"text": "（1）原发性痴呆，早期表现为记忆损害，渐进加重，同时伴其他认知功能损害如失语、失用、失认，且缺乏相关的脑影像学检查的局灶性损害；", "label": 5, "label_text": "Multiple", "id": "s1122"}
{"text": " 10、肝肾功能不全等并发症者", "label": 5, "label_text": "Multiple", "id": "s1123"}
{"text": " 2)疾病特点：需要输尿管镜下钬激光碎石；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1124"}
{"text": " 8．不配合检查和治疗的患者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s1125"}
{"text": " ① 排卵稀发和/或无排卵。", "label": 4, "label_text": "Disease", "id": "s1126"}
{"text": " 4、左室射血分数≤40％；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1127"}
{"text": " (6)可疑或确诊胎儿发育（染色体、心脏、肾脏等）异常者；", "label": 11, "label_text": "Diagnostic", "id": "s1128"}
{"text": " 10.在近3个月内有滥用酒精和药物者", "label": 2, "label_text": "Addictive Behavior", "id": "s1129"}
{"text": " (10)患有精神分裂症等干扰参与本临床研究的精神疾病者；", "label": 4, "label_text": "Disease", "id": "s1130"}
{"text": "1.对研究药物组成成分过敏或过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s1131"}
{"text": " ＊无基因突变且一线化疗失败或不能耐受的患者，或者服用靶向药出现耐药进展的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1132"}
{"text": "1.石蜡包埋病理组织切片样本且符合样本采集要求；", "label": 29, "label_text": "Receptor Status", "id": "s1133"}
{"text": " 11、未签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1134"}
{"text": " ④ 严重感染者或代谢性疾病", "label": 4, "label_text": "Disease", "id": "s1135"}
{"text": " 9.颈部手术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1136"}
{"text": " （4）BMI≤18.5或≥23.9；", "label": 9, "label_text": "Risk Assessment", "id": "s1137"}
{"text": "1.同时长期服用非甾体类消炎药(NSAIDS)，银杏叶提取物和其他胆碱酯酶抑制剂", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1138"}
{"text": "1.年龄≥65岁", "label": 3, "label_text": "Age", "id": "s1139"}
{"text": " 9.参加试验前3个月内参与其它临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1140"}
{"text": " 前期依从性较差的患者", "label": 8, "label_text": "Compliance with Protocol", "id": "s1141"}
{"text": " 9.依从性差，不能配合强化治疗，饮食运动不规律的患者。", "label": 5, "label_text": "Multiple", "id": "s1142"}
{"text": " 7.受试者志愿受试并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1143"}
{"text": " （4） 年龄45-60岁", "label": 3, "label_text": "Age", "id": "s1144"}
{"text": " 6.在本研究开始前已接受过PE或血滤等血液净化技术治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1145"}
{"text": " 2. 满足至少一下一项：pT3a-4，R1，pN1，GS≥8或PSA＞0.1ng/ml；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1146"}
{"text": " ④ 严重的躯体疾病或药物副作用，无法进行康复治疗；", "label": 5, "label_text": "Multiple", "id": "s1147"}
{"text": " C、有病理学的诊断依据者", "label": 11, "label_text": "Diagnostic", "id": "s1148"}
{"text": " 3. 参加其他干预性或非干预性临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1149"}
{"text": " 9. 备孕期或近期备孕可能者；有生育可能的女性（定义为生理上能怀孕的所有女性，除非在整个研究期间内使用有效的避孕方法（对有无生育可能和有效避孕方法在方案中进行具体约定）；妊娠或哺乳（授乳）期妇女（妊娠定义为女性受孕后，终止妊娠前的状态，以hCG实验室检查阳性结果为准）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1150"}
{"text": " 3)消化道溃疡活动期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1151"}
{"text": " 属于高血压肾损害分期为晚期者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1152"}
{"text": " （3）患者为未经治疗的、或未经过规范治疗的初治病人；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1153"}
{"text": " 2.24小时蛋白尿定量> 3.0g者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1154"}
{"text": " 6.存在急性病症，如尿路感染、发热、心力衰竭等；", "label": 4, "label_text": "Disease", "id": "s1155"}
{"text": " 3)女方配偶精子DNA损伤：采用SCD方法检测精液原液精子碎片指数＞27.3%，至少2次；", "label": 9, "label_text": "Risk Assessment", "id": "s1156"}
{"text": " ②冠脉造影证实冠脉狭窄率＜50%", "label": 11, "label_text": "Diagnostic", "id": "s1157"}
{"text": " 11、女性：须行手术绝育或绝经后，治疗期间及结束后6个月内避孕；非哺乳期；男性：须行手术绝育或在治疗期间及结束后6个月内避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1158"}
{"text": " 3.接受过抗肿瘤治疗，包括化疗、放疗或者靶向治疗（包括且不限于单克隆抗体、小分子酪氨酸激酶抑制剂等）或者进行其他药物临床试验", "label": 5, "label_text": "Multiple", "id": "s1159"}
{"text": " (5)改良Ross心功能评级≥3级；", "label": 9, "label_text": "Risk Assessment", "id": "s1160"}
{"text": " （2）符合室缺标准，年龄大于3岁，体重大于10KG", "label": 5, "label_text": "Multiple", "id": "s1161"}
{"text": " 8.TG>5.6mmol/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s1162"}
{"text": " 7.可耐受全身麻醉", "label": 7, "label_text": "Allergy Intolerance", "id": "s1163"}
{"text": " 2.复治患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1164"}
{"text": " iii.减数14,24,（智齿除外）", "label": 30, "label_text": "Oral related", "id": "s1165"}
{"text": " (8) 已知对临床试验药物组成成份过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s1166"}
{"text": " 4、小于18岁或大于80岁", "label": 3, "label_text": "Age", "id": "s1167"}
{"text": " 6.孕妇，产后或哺乳期后28天内", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1168"}
{"text": " iv．凡在入组后发现不符合试验方案者。", "label": 21, "label_text": "Researcher Decision", "id": "s1169"}
{"text": " （2）ESSEN评分≥3分", "label": 9, "label_text": "Risk Assessment", "id": "s1170"}
{"text": " 3)预期生存期＜3个月者。", "label": 23, "label_text": "Life Expectancy", "id": "s1171"}
{"text": "1.孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1172"}
{"text": " （2） 近 3 个月服用乳果糖、益生菌或门冬氨酸鸟氨酸，近 1 周使用抗生素或镇静药；", "label": 5, "label_text": "Multiple", "id": "s1173"}
{"text": " 4.患有严重的代谢性疾病、内分泌疾病及血液系统疾病者", "label": 4, "label_text": "Disease", "id": "s1174"}
{"text": " （4）自愿参加并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s1175"}
{"text": " (三)年龄≤65岁", "label": 3, "label_text": "Age", "id": "s1176"}
{"text": "1.年龄≥6岁；", "label": 3, "label_text": "Age", "id": "s1177"}
{"text": " 凝血酶原时间（PT）≤ 16.00S；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1178"}
{"text": " 4）研究者认为患者有其他可能影响研究结果或导致本研究被迫中途终止的因素", "label": 21, "label_text": "Researcher Decision", "id": "s1179"}
{"text": " II 最后一次化疗与疾病进展间隔不足1年的；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1180"}
{"text": " 8.滥用药物者、酗酒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s1181"}
{"text": " 5.内侧颞叶、海马体、运动辅助区(SMA)及小脑由MRI监定为未受损；", "label": 11, "label_text": "Diagnostic", "id": "s1182"}
{"text": " 4.年龄为45～80岁", "label": 3, "label_text": "Age", "id": "s1183"}
{"text": " 5. 碘过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s1184"}
{"text": "1）凡未按规定治疗，无法确定疗效或资料不全等影响疗效判定者。", "label": 5, "label_text": "Multiple", "id": "s1185"}
{"text": " （7）近一月内使用长效抗精神病药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1186"}
{"text": " 9.患有精神、神经疾病，或不能正确表达意愿患者；", "label": 5, "label_text": "Multiple", "id": "s1187"}
{"text": " ⑷美罗培南连续用药时间超过2天；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1188"}
{"text": " 8.糖尿病合并严重的慢性并发症（如糖尿病肾病、糖尿病眼底病变）", "label": 4, "label_text": "Disease", "id": "s1189"}
{"text": " 3. 组织学或细胞学证实的局部晚期或转移性肺鳞癌。混合性肺鳞癌受试者，若所含鳞癌成分>50%，由研究者根据具体情况判断是否入组。", "label": 5, "label_text": "Multiple", "id": "s1190"}
{"text": " 5. 患侧输尿管狭窄、UPJ狭窄、解剖结构异常(肾内型肾盂、肾下垂、马蹄肾等)；", "label": 4, "label_text": "Disease", "id": "s1191"}
{"text": " (4)有神经阻滞或全身麻醉禁忌", "label": 5, "label_text": "Multiple", "id": "s1192"}
{"text": " (20) 不能耐受活性炭者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1193"}
{"text": " （2）NIHSS>25 分", "label": 9, "label_text": "Risk Assessment", "id": "s1194"}
{"text": " 凝血机制障碍的患者（INR＞1.5或凝血酶原时间PT＞ULN+4妙或APTT＞1.5ULN），具有出血倾向或正在接受溶栓或抗凝治疗。", "label": 5, "label_text": "Multiple", "id": "s1195"}
{"text": " 2) 有中枢神经系统、心血管系统、肝肾功能不全、消化道系统（特别是胰腺炎史）、呼吸系统、代谢及骨骼系统疾病病史（特别是：低血压、体位性低血压、帕金森病、癫痫、头痛或偏头痛等），或其他任何可能影响研究结果的疾病及生理条件者。", "label": 5, "label_text": "Multiple", "id": "s1196"}
{"text": " 3、自觉无身体其他不适，且愿意配合医生者。", "label": 13, "label_text": "Consent", "id": "s1197"}
{"text": "1、确诊的HIV/AIDS患者。", "label": 11, "label_text": "Diagnostic", "id": "s1198"}
{"text": " 13. 有器官移植病史或正等待器官移植的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1199"}
{"text": " （9）近3个月内参加其他药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1200"}
{"text": " 6) 精神病患者。", "label": 4, "label_text": "Disease", "id": "s1201"}
{"text": " 3 预期存活时间 ≥3个月", "label": 23, "label_text": "Life Expectancy", "id": "s1202"}
{"text": " 2.同时或异时（5年内）恶性肿瘤（除外有效治疗的鳞状细胞或基底细胞癌）病史", "label": 4, "label_text": "Disease", "id": "s1203"}
{"text": "1. 肺功能差不能耐受单肺通气的患者", "label": 5, "label_text": "Multiple", "id": "s1204"}
{"text": " (10) 已知对乳剂、阿片类药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1205"}
{"text": " ③ 体重≥40kg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1206"}
{"text": " 7. 不愿参加试验并不能配合", "label": 13, "label_text": "Consent", "id": "s1207"}
{"text": " 3.能够阅读和理解中文", "label": 25, "label_text": "Literacy", "id": "s1208"}
{"text": "1.有过手术减肥或滥用减重药经历者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1209"}
{"text": " 8、血液学检查：", "label": 12, "label_text": "Laboratory Examinations", "id": "s1210"}
{"text": " （6）依从性良好；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1211"}
{"text": " 3）二线化疗失败的晚期小细胞肺癌患者（治疗失败的定义：治疗过程中疾病进展或治疗结束后复发、毒副作用不可耐受）。", "label": 4, "label_text": "Disease", "id": "s1212"}
{"text": " （6）合并支气管扩张、支气管哮喘、活动性肺结核、闭塞性细支气管炎、弥漫性泛细支气管炎、肺栓塞、气胸、胸腔积液患者；", "label": 4, "label_text": "Disease", "id": "s1213"}
{"text": " 8)有严重过敏史或特异性体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1214"}
{"text": " 9.首次治疗的肝细胞癌。", "label": 4, "label_text": "Disease", "id": "s1215"}
{"text": " （7）不能完成临床试验所需要的条款。", "label": 17, "label_text": "Capacity", "id": "s1216"}
{"text": " 9、合并进展性恶性肿瘤或慢性消耗性疾病；", "label": 4, "label_text": "Disease", "id": "s1217"}
{"text": " （4）年龄18-70岁。", "label": 3, "label_text": "Age", "id": "s1218"}
{"text": "1. 女性，年龄18~70岁；", "label": 5, "label_text": "Multiple", "id": "s1219"}
{"text": " E.近期有严重咯血、剧烈咳嗽、呼吸困难或患者不能合作。", "label": 5, "label_text": "Multiple", "id": "s1220"}
{"text": " b.曾行≥1次IVF-ET胚胎未成功着床者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1221"}
{"text": "1.筛选或基线时12导联心电图（ECGs）异常，包括QTc（QTcB）>450 ms，或心率>100 bpm，或QRS >120 ms，或PR >200 ms", "label": 12, "label_text": "Laboratory Examinations", "id": "s1222"}
{"text": " 6. 肾小球滤过率<60 ml / min / 1.73m2（基于实验前1个月实验室检查结果）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1223"}
{"text": " 2、需积极或长期治疗的恶性肿瘤患者、先天性凝血因子异常(血友病) 、严重溶血性及再生不良性贫血、需终身治疗的全身性自生免疫病患者。", "label": 4, "label_text": "Disease", "id": "s1224"}
{"text": " 4、ASA分级为I-III级", "label": 9, "label_text": "Risk Assessment", "id": "s1225"}
{"text": " 2. 无明显黄疸、腹水和下肢水肿或肝外转移；", "label": 1, "label_text": "Sign", "id": "s1226"}
{"text": "⑴符合西医诊断标准，具有典型胃食管反流症状1个月以上；", "label": 11, "label_text": "Diagnostic", "id": "s1227"}
{"text": " （2）多囊卵巢综合征、子宫畸形、宫腔重度粘连者；", "label": 4, "label_text": "Disease", "id": "s1228"}
{"text": " （2）术前凝血功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1229"}
{"text": " （5）血压未获满意控制的高血压病患者（静息收缩压≥160mmHg，和/或舒张压≥100 mmHg）；", "label": 5, "label_text": "Multiple", "id": "s1230"}
{"text": " （3）具备基本的视听说能力，尚有语言交流能力。", "label": 25, "label_text": "Literacy", "id": "s1231"}
{"text": " 成熟的多房性细菌性肝脓肿（脓腔周围包囊形成）", "label": 4, "label_text": "Disease", "id": "s1232"}
{"text": "1、间歇状态、重度及急性加重期的哮喘患者。", "label": 4, "label_text": "Disease", "id": "s1233"}
{"text": " 5、孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1234"}
{"text": " 难治的定义是指没有有效的治疗选择，并且采用当前可用的治疗干预后，具有有限的预后（生存期只有几个月到2年）；", "label": 5, "label_text": "Multiple", "id": "s1235"}
{"text": " 鼻内用或系统使用皮质类固醇激素＜1月", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1236"}
{"text": "1.高度过敏体质或有严重过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1237"}
{"text": " 10.实验前3个月曾参加过其它临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1238"}
{"text": " 4.病人已参加其他前瞻性临床研究，可能存在影响此研究随访观察因素者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1239"}
{"text": " 2 腹主动脉旁淋巴结转移及远处转移者。", "label": 4, "label_text": "Disease", "id": "s1240"}
{"text": " 3.匹兹堡睡眠质量指数(PSQI)量表总分>7分者；", "label": 9, "label_text": "Risk Assessment", "id": "s1241"}
{"text": " （3）接受过二线治疗（化疗或者靶向治疗）失败", "label": 0, "label_text": "Therapy or Surgery", "id": "s1242"}
{"text": " 3)2型糖尿病患者，符合WHO1999年诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s1243"}
{"text": " 4. 血PSA＞4ng/ml；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1244"}
{"text": " （3）3个月内用过已知对某些脏器有损害的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1245"}
{"text": " 5.无严重心、肺、肝、肾等重要脏器疾病史", "label": 4, "label_text": "Disease", "id": "s1246"}
{"text": " （5）合并有活动期恶性肿瘤、脑中风、心肌梗塞等严重原发性疾病；", "label": 4, "label_text": "Disease", "id": "s1247"}
{"text": " 4）有ATG使用禁忌症；", "label": 4, "label_text": "Disease", "id": "s1248"}
{"text": " 5、要求术后使用镇痛泵并签署知情同意书", "label": 5, "label_text": "Multiple", "id": "s1249"}
{"text": " ⑦病态肥胖（BMI>35 kg/m2）", "label": 5, "label_text": "Multiple", "id": "s1250"}
{"text": " （2）计划在全身麻醉下行机械通气，且持续机械通气大于6小时", "label": 38, "label_text": "Nursing", "id": "s1251"}
{"text": " （5）AMI时已行干细胞治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1252"}
{"text": "（1）上海市户籍，年龄在2岁-18岁，有阳光宝宝卡或残疾人证明，或者正在申领的过程中。", "label": 5, "label_text": "Multiple", "id": "s1253"}
{"text": " 4.无药物滥用史。", "label": 2, "label_text": "Addictive Behavior", "id": "s1254"}
{"text": "1. 符合餐后不适综合征的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s1255"}
{"text": " (8) 近3个月内参加过或正在参加其他药物临床试验者.", "label": 15, "label_text": "Enrollment in other studies", "id": "s1256"}
{"text": " 4.癫痫持续状态发作者；", "label": 4, "label_text": "Disease", "id": "s1257"}
{"text": " 7、术中患者不输注含糖溶液。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1258"}
{"text": " （3）卡氏评分≥70分或者ECOG 0-1分；", "label": 9, "label_text": "Risk Assessment", "id": "s1259"}
{"text": " ③尿频（日均排尿次数≥8次）；", "label": 4, "label_text": "Disease", "id": "s1260"}
{"text": " 6.必须在进行任何筛选评估前，获得患者的知情同意等。", "label": 13, "label_text": "Consent", "id": "s1261"}
{"text": " （4）患者临床用药稳定至少一月", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1262"}
{"text": " (4)入组的3个月前曾进行心理治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1263"}
{"text": " 5) 签署书面知情同意书", "label": 13, "label_text": "Consent", "id": "s1264"}
{"text": " 6.预计生存期≥12周；", "label": 23, "label_text": "Life Expectancy", "id": "s1265"}
{"text": " 2）进行性加重的梗阻性黄疸；", "label": 4, "label_text": "Disease", "id": "s1266"}
{"text": "1)符合DSM-IV诊断标准的分裂样情感性精神障碍、心境障碍、精神发育迟滞、广泛性发育障碍、谵妄、痴呆、记忆障碍或其他认知障碍者；", "label": 11, "label_text": "Diagnostic", "id": "s1267"}
{"text": " d. Child-pugh评分A-B级", "label": 9, "label_text": "Risk Assessment", "id": "s1268"}
{"text": " 2. 神志状态恶化或意识障碍者", "label": 28, "label_text": "Symptom", "id": "s1269"}
{"text": " 11)试验前2周内服用过特殊饮食（包括火龙果、芒果、柚子、和/或黄嘌呤饮食等）或有剧烈运动，或其他影响药物吸收、分布、代谢、排泄等因素者。", "label": 5, "label_text": "Multiple", "id": "s1270"}
{"text": "1、年龄＜20岁或＞55岁；", "label": 3, "label_text": "Age", "id": "s1271"}
{"text": "1.行乳突缩腔的患者；", "label": 4, "label_text": "Disease", "id": "s1272"}
{"text": " ⑧滥用药物或毒品者。", "label": 2, "label_text": "Addictive Behavior", "id": "s1273"}
{"text": " ⑤ 常规抗精神病药物治疗，剂量稳定4周以上；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1274"}
{"text": " 3.初期腭裂整复；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1275"}
{"text": " ③正在接受或者准备接受贝伐单抗、沙利度胺或介入治疗的患者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1276"}
{"text": " 6. 60天内参加过其他临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s1277"}
{"text": " (2）ASA分级I-II级；", "label": 9, "label_text": "Risk Assessment", "id": "s1278"}
{"text": "   7.血液、肝肾功能符合要求：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1279"}
{"text": "(1)18-65周岁拟行择期颌面外科手术因外科需要拟经鼻气管插管患者;", "label": 5, "label_text": "Multiple", "id": "s1280"}
{"text": " 5、月经期及妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1281"}
{"text": " 6) 失访或其他原因不能明确是否发生持续咳嗽者。", "label": 5, "label_text": "Multiple", "id": "s1282"}
{"text": " 1)性别：入选的健康受试者应有适当的性别比例，同意在试验期间及试验后3个月内不发生无保护性性行为，且试验期间必须采取物理方式避孕；其中女性必须满足以下条件：已行手术绝育；或具有生育能力，但入组前血妊娠（β-HCG）妊娠检查结果无临床意义者；", "label": 5, "label_text": "Multiple", "id": "s1283"}
{"text": " 4. 最近6个月内发生过心肌梗死、不稳定心绞痛、晕厥、脑血管意外、间歇性跛行、广泛动脉粥样硬化伴有血管内血栓病史；", "label": 4, "label_text": "Disease", "id": "s1284"}
{"text": " 5.30-75岁；", "label": 3, "label_text": "Age", "id": "s1285"}
{"text": " 6. 甲状腺功能亢进或减退（不包括亚临床甲亢和亚临床甲减）;", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1286"}
{"text": " 预计生存期超过6个月。", "label": 23, "label_text": "Life Expectancy", "id": "s1287"}
{"text": " 6）对食物有特殊要求，不愿意或没有能力完成研究期间的饮食控制计划。", "label": 5, "label_text": "Multiple", "id": "s1288"}
{"text": " (6)合并有心血管、肝、肾和血液系统等严重原发性疾病、精神病患者；", "label": 4, "label_text": "Disease", "id": "s1289"}
{"text": " 6  足够的肝肾功能：总胆红素≤正常值上限（ULN）；AST和ALT≤2.5倍ULN；碱性磷酸酶≤5倍ULN；肌酐清除率≥80 mL/min；", "label": 5, "label_text": "Multiple", "id": "s1290"}
{"text": "1）有下列疾病标志和症状或者有疾病但不被限制的，包括克罗恩病、结节病、慢性腹泻、心脏病、类风湿关节炎、系统性红斑狼疮（SLE），和癌症；", "label": 4, "label_text": "Disease", "id": "s1291"}
{"text": " 18-65周岁，性别不限", "label": 5, "label_text": "Multiple", "id": "s1292"}
{"text": " (2)3个月内参加过其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1293"}
{"text": " (7)术前评估存在或可能存在困难气道的情况", "label": 1, "label_text": "Sign", "id": "s1294"}
{"text": " 10)有出血倾向疾病者；", "label": 4, "label_text": "Disease", "id": "s1295"}
{"text": " b）且SOFA评分大于等于2分。", "label": 9, "label_text": "Risk Assessment", "id": "s1296"}
{"text": " 6.语言理解有严重障碍者。", "label": 17, "label_text": "Capacity", "id": "s1297"}
{"text": " F 食管/胃有手术史（儿童期幽门肌切开术除外）", "label": 0, "label_text": "Therapy or Surgery", "id": "s1298"}
{"text": " 3、年龄20-40岁；", "label": 3, "label_text": "Age", "id": "s1299"}
{"text": "（1）病理诊断为胃癌或结直肠癌并且行根治性切除患者，未计划同时行其他脏器切除；", "label": 5, "label_text": "Multiple", "id": "s1300"}
{"text": " 2）精神病患者。", "label": 4, "label_text": "Disease", "id": "s1301"}
{"text": " 10）研究人员认为其他原因不适合临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s1302"}
{"text": " F、经术前评估，适合进行无痛胃肠镜或者结肠镜检查/治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1303"}
{"text": " (12)不能遵守中心标准饮食者；", "label": 18, "label_text": "Diet", "id": "s1304"}
{"text": " 5.12.研究者认为不适合入组的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s1305"}
{"text": " 4.签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1306"}
{"text": " （6）无既往心脑血管疾病，经24小时动态心电图检查排除房室传导阻滞；", "label": 5, "label_text": "Multiple", "id": "s1307"}
{"text": " ③BMI >20且< 30，近三个月内体重稳定；", "label": 5, "label_text": "Multiple", "id": "s1308"}
{"text": " 9. 嗜烟酒者（每周饮用14个单位的酒精：1单位=啤酒285 ml，或烈酒25 ml，或葡萄酒1杯；每日吸烟≥5支)和/或在试验期间不能禁烟和禁酒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s1309"}
{"text": " 19)在使用研究药物前24 小时摄取了巧克力、任何含咖啡因或富含黄嘌呤食物或饮料；", "label": 18, "label_text": "Diet", "id": "s1310"}
{"text": "1.无慢性肝炎、肝硬化及肝癌患者，因良性肝病行手术者；", "label": 5, "label_text": "Multiple", "id": "s1311"}
{"text": " ②近三个月内接受过中医或针灸治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1312"}
{"text": " 4.  签署知情同意书，并同意配合本试验方案、遵守治疗后护理并按时复诊。", "label": 5, "label_text": "Multiple", "id": "s1313"}
{"text": " 5.沟通交流障碍患者；", "label": 25, "label_text": "Literacy", "id": "s1314"}
{"text": " 6.入组前完善头颈部病变部位CT，淋巴结检查及内镜检查；", "label": 34, "label_text": "Device", "id": "s1315"}
{"text": " （二）男女不限", "label": 35, "label_text": "Gender", "id": "s1316"}
{"text": " 10）本研究给药前90日内曾献血超过400ml者；", "label": 14, "label_text": "Blood Donation", "id": "s1317"}
{"text": " （12）最近2月内参与其他试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s1318"}
{"text": " 4.清创后溃疡皮肤缺损面积在1-20cm2；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1319"}
{"text": " 4.严重内科疾病；", "label": 4, "label_text": "Disease", "id": "s1320"}
{"text": " 2.入选时明确合并细菌感染。", "label": 4, "label_text": "Disease", "id": "s1321"}
{"text": " 6）卧位收缩压<90mmHg或>180mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1322"}
{"text": " 14、过敏体质和长期使用激素类药物者", "label": 7, "label_text": "Allergy Intolerance", "id": "s1323"}
{"text": " 3、前交叉韧带(ACL)脆弱、断裂或缺失，既往行ACL重建或胫骨高位截骨术的患者。", "label": 5, "label_text": "Multiple", "id": "s1324"}
{"text": " ④肾移植术后；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1325"}
{"text": " 2）GCS＜12分；", "label": 9, "label_text": "Risk Assessment", "id": "s1326"}
{"text": " 4、对于女性患者，临床试验期间直至OMS0728服药结束/中止后2年内不希望妊娠或无妊娠可能性", "label": 5, "label_text": "Multiple", "id": "s1327"}
{"text": " （3）病情程度属Ⅰ级～Ⅲ级的稳定期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1328"}
{"text": " f.既往接受过放射治疗（若为非黑色素瘤的皮肤癌且既往病灶位于放疗的靶区之外，则除外）。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1329"}
{"text": " （4）2型糖尿病合并糖尿病酮症酸中毒或糖尿病高渗性昏迷者；", "label": 4, "label_text": "Disease", "id": "s1330"}
{"text": " 4. 患者心率≤ 50 次/min，或即使大剂量血管活性药使用下血压仍≤ 90 mmHg ；", "label": 5, "label_text": "Multiple", "id": "s1331"}
{"text": "1.一般情况差，不能客观描述症状，或有严重感染，呼吸功能不全等不能主动配合；", "label": 4, "label_text": "Disease", "id": "s1332"}
{"text": "1.抽血恐惧者", "label": 4, "label_text": "Disease", "id": "s1333"}
{"text": " 3.患者或者其法定监护人同意并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1334"}
{"text": " （3）宫腔粘连操作过程中出现子宫穿孔等并发症者；", "label": 4, "label_text": "Disease", "id": "s1335"}
{"text": "1、年龄不足18岁或超过70岁", "label": 3, "label_text": "Age", "id": "s1336"}
{"text": " 2.营养缺乏导致的佝偻病，如维生素D摄入不足、吸收和代谢障碍所致佝偻病；", "label": 4, "label_text": "Disease", "id": "s1337"}
{"text": " 6. 新发或复发的肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s1338"}
{"text": " 2.患者处于可预知的垂死状态；", "label": 1, "label_text": "Sign", "id": "s1339"}
{"text": " （2 ）常规超声图像显示有恶性征象，如(病灶纵横比>1，内部有小钙化灶，边界不清等)；", "label": 5, "label_text": "Multiple", "id": "s1340"}
{"text": "（1）研究者认为不适合参加本试验的患者；", "label": 21, "label_text": "Researcher Decision", "id": "s1341"}
{"text": " 7.既往有颈部手术史。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1342"}
{"text": " （7）肝肾功能异常（血清谷丙转氨酶>正常上限2倍，肌酐>125umol/L）", "label": 5, "label_text": "Multiple", "id": "s1343"}
{"text": " 4、没有肿瘤转移的临床证据", "label": 24, "label_text": "Neoplasm Status", "id": "s1344"}
{"text": " 9.血管内异物（例如起搏器、人工心脏瓣膜）；", "label": 34, "label_text": "Device", "id": "s1345"}
{"text": "(1)有严重的精神病;", "label": 4, "label_text": "Disease", "id": "s1346"}
{"text": " 15.筛选前3个月接受过其他药物试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1347"}
{"text": "①年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s1348"}
{"text": " 10.尿HCG阳性或在研究期间不能使用可靠方法避孕者（由研究者判断）", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1349"}
{"text": " ③ 包括结核、克隆氏病等所致的高位肛瘘患者；", "label": 4, "label_text": "Disease", "id": "s1350"}
{"text": " 15)  存在EPO抵抗的患者；EPO抵抗指皮下注射rHuEPo达到300IU／(kg?wk)(总量20000IU／wk)或静脉注射rHuEPO500IU／(kg?wk)(总量30000Iu／周)治疗4个月后，Hb仍不能达到或维持靶目标值；", "label": 5, "label_text": "Multiple", "id": "s1351"}
{"text": " 2)冠脉CT或冠脉造影提示三支主要血管中至少一支狭窄≥50%（包括急诊PCI、择期PCI及药物治疗的患者）；", "label": 11, "label_text": "Diagnostic", "id": "s1352"}
{"text": " 10)研究者认为存在影响受试者参加试验或结果评价的任何因素。", "label": 21, "label_text": "Researcher Decision", "id": "s1353"}
{"text": "1.年龄<18岁的未治AML；", "label": 5, "label_text": "Multiple", "id": "s1354"}
{"text": " （9）有研究者认为不宜参加试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s1355"}
{"text": " （7）中枢神经系统受侵；", "label": 4, "label_text": "Disease", "id": "s1356"}
{"text": " h) 入组患者在治疗和随访期内不改变服用解痉药物的服用剂量；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1357"}
{"text": " 10)类固醇辅助治疗开始之前5日内接种过风疹减毒活疫苗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1358"}
{"text": "1. 曾行EST或十二指肠乳头扩张术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1359"}
{"text": " 4) 影像学见存在异位腔静脉等解剖异常可能造成迷走神经辨认困难的;肺门、纵隔淋巴结有钙化或淋巴结融合表现的；", "label": 11, "label_text": "Diagnostic", "id": "s1360"}
{"text": "1.患有其他代谢性疾病，如糖尿病、肾病、血液系统疾病等。", "label": 4, "label_text": "Disease", "id": "s1361"}
{"text": " 7.主要器官功能正常，即符合下列标准：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1362"}
{"text": " 2.慢性乙肝患者，既往接受核苷（酸）类似物治疗至少1年，HBV DNA低于检测下限；", "label": 5, "label_text": "Multiple", "id": "s1363"}
{"text": " （7）不愿意参加此研究", "label": 13, "label_text": "Consent", "id": "s1364"}
{"text": " 2. 严重干眼；；", "label": 4, "label_text": "Disease", "id": "s1365"}
{"text": " 3、肺叶切除术", "label": 0, "label_text": "Therapy or Surgery", "id": "s1366"}
{"text": " （5）妊娠或哺乳期妇女以及无法耐受本治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s1367"}
{"text": " 20)血小板计数（PLT）<100×109/L或>600×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1368"}
{"text": " 9. 肿瘤史；", "label": 4, "label_text": "Disease", "id": "s1369"}
{"text": "1. 年龄大于18周岁；", "label": 3, "label_text": "Age", "id": "s1370"}
{"text": " 6）酒精和/或药物的滥用及依赖。", "label": 2, "label_text": "Addictive Behavior", "id": "s1371"}
{"text": " 2)无眼球震颤，具有良好的固视能力；", "label": 28, "label_text": "Symptom", "id": "s1372"}
{"text": " 3.住ICU时间少于24小时的患者", "label": 5, "label_text": "Multiple", "id": "s1373"}
{"text": " 签署知情同意书，且自愿接受干预研究。", "label": 13, "label_text": "Consent", "id": "s1374"}
{"text": "年龄自18-65岁之间，性别不限。", "label": 5, "label_text": "Multiple", "id": "s1375"}
{"text": " ②依从性差，不配合治疗者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1376"}
{"text": "1. 下呼吸道感染及其他呼吸、消化、泌尿、血液系统等疾病感染致发热者。", "label": 4, "label_text": "Disease", "id": "s1377"}
{"text": " 11. 准备妊娠、妊娠或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1378"}
{"text": " ③患者除精神分裂症外，还合并以下疾病，如癫痫、老年痴呆、酒精及药物滥用、临床显著的躯体性和精神性疾病；", "label": 5, "label_text": "Multiple", "id": "s1379"}
{"text": " 5.拒绝参加本临床研究、或拒绝签署知情同意者。", "label": 13, "label_text": "Consent", "id": "s1380"}
{"text": "①癫痫持续状态。", "label": 4, "label_text": "Disease", "id": "s1381"}
{"text": " (6)孕妇、哺乳期妇女或计划怀孕的患者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1382"}
{"text": " 2、择期拟行肝癌切除术、结肠癌根治术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1383"}
{"text": " 5．年龄18-65岁。", "label": 3, "label_text": "Age", "id": "s1384"}
{"text": " （6）患者有严重或进行性的心血管或非心血管疾病，预期寿命不到12个月", "label": 5, "label_text": "Multiple", "id": "s1385"}
{"text": " （2）乙肝所致肝衰竭合并其他病毒感染：抗HAVIgM、抗HCV、抗HDV、抗HEV以及抗HIV任何一项阳性；", "label": 5, "label_text": "Multiple", "id": "s1386"}
{"text": " 肠麻痹、肠梗阻、间质性肺炎、活动性胃溃疡；", "label": 4, "label_text": "Disease", "id": "s1387"}
{"text": " 2.既往有肝肾疾患史；", "label": 4, "label_text": "Disease", "id": "s1388"}
{"text": " ③年龄在18－75岁之间；", "label": 3, "label_text": "Age", "id": "s1389"}
{"text": " 年龄大于35岁", "label": 3, "label_text": "Age", "id": "s1390"}
{"text": " 11、合并有神经、精神疾患而无法合作或不愿合作者；", "label": 5, "label_text": "Multiple", "id": "s1391"}
{"text": " （7）麻醉手术过程中出现严重不良反应（气道困难、出现过敏反应）及术后需送重症监护室者。", "label": 5, "label_text": "Multiple", "id": "s1392"}
{"text": " 4.签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1393"}
{"text": " 神经肌肉疾病", "label": 4, "label_text": "Disease", "id": "s1394"}
{"text": " 4)体能ECOG评分 0–3分；", "label": 9, "label_text": "Risk Assessment", "id": "s1395"}
{"text": "(1)、频繁呕吐无法进食或禁食患儿；", "label": 5, "label_text": "Multiple", "id": "s1396"}
{"text": " 8. 受试者无主要器官的功能障碍，血常规、肺、肝、肾功能及心脏功能正常，实验室化验指标必须符合下列要求：血液学：白细胞≥4.0G/L、中性粒细胞≥2.0G/L、血小板计数≥100G/L、血红蛋白≥100g/L。肝功能：正常范围。肾功能：正常范围。肺功能：FEV1>50%，轻-中度肺功能受损；", "label": 5, "label_text": "Multiple", "id": "s1397"}
{"text": "   3、有穴位刺激禁忌者", "label": 7, "label_text": "Allergy Intolerance", "id": "s1398"}
{"text": " （1）符合功能性消化不良罗马IV诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s1399"}
{"text": "1.抗癫痫药物（AEDs）给药后，未能接受完成至少1次有效性/安全性评估患者；", "label": 5, "label_text": "Multiple", "id": "s1400"}
{"text": " 3.已阅读了受试者须知，同意治疗并签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s1401"}
{"text": "1.国外、港、澳、台湾或其他地区，估计术后难以追踪、随访者。", "label": 5, "label_text": "Multiple", "id": "s1402"}
{"text": " 8)在筛选前 2 个月内或在筛选和随机分配之间患有相关传染病；", "label": 4, "label_text": "Disease", "id": "s1403"}
{"text": "A、经临床症状及皮肤损伤检查等证实符合国际诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s1404"}
{"text": " b.疼痛评分NRS大于3分", "label": 9, "label_text": "Risk Assessment", "id": "s1405"}
{"text": "1.凝血功能障碍有出血倾向者", "label": 5, "label_text": "Multiple", "id": "s1406"}
{"text": " (3)参加疾病登记研究的医师认为，患者可能无法提供持续的随访信息", "label": 21, "label_text": "Researcher Decision", "id": "s1407"}
{"text": " 1）有未控制的或症状性心绞痛史；", "label": 4, "label_text": "Disease", "id": "s1408"}
{"text": " 4.妊娠或哺乳期妇女，或准备妊娠妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1409"}
{"text": " 3） 脊髓损伤后开展康复训练，症状无明显改善;", "label": 5, "label_text": "Multiple", "id": "s1410"}
{"text": " 3.患2型糖尿病（临床诊断）12个月以上；", "label": 11, "label_text": "Diagnostic", "id": "s1411"}
{"text": " 10)合并严重肝肾功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1412"}
{"text": "1）拒绝参加本研究；", "label": 13, "label_text": "Consent", "id": "s1413"}
{"text": "1.合并有脑出血；", "label": 1, "label_text": "Sign", "id": "s1414"}
{"text": " 2.血液检验：肿瘤标志物（CA125＜35U/L）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1415"}
{"text": " 7)能致使受试者不能遵循研究计划甚至危及患者安全的合并症或社会环境。", "label": 5, "label_text": "Multiple", "id": "s1416"}
{"text": " （2）中医辨证属痰浊内阻、湿热瘀结证者；", "label": 11, "label_text": "Diagnostic", "id": "s1417"}
{"text": " 6.有同侧肺叶切除史", "label": 0, "label_text": "Therapy or Surgery", "id": "s1418"}
{"text": " 3. 抗病毒治疗半年以上CD4仍然小于200个/μL；", "label": 5, "label_text": "Multiple", "id": "s1419"}
{"text": " （2）本次卒中是由于外科或血管介入操作，如颈动脉内膜剥脱术、血管造影或支架术、心脏手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1420"}
{"text": " 2.中医辨证符合气虚证及脾气虚证标准，且“中医气虚证量化评分”≥10分；", "label": 5, "label_text": "Multiple", "id": "s1421"}
{"text": "中危-2或高危的MDS；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1422"}
{"text": " 7）有其他影响激素分泌和代谢的未经控制的内分泌疾病（如：甲亢、甲减、肾上腺疾病等）；", "label": 4, "label_text": "Disease", "id": "s1423"}
{"text": " ④接受新辅助治疗患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1424"}
{"text": "1.符合围绝经期诊断标准和更年期综合征标准；", "label": 11, "label_text": "Diagnostic", "id": "s1425"}
{"text": " 2) 肝功能：血清总胆红素（TBIL）≤1.5倍正常上限（ULN），丙氨酸氨基转移酶（ALT）和/或天门冬氨酸氨基转移酶（AST）≤2.5倍ULN，若肝功能异常是由于肝细胞癌或肿瘤肝转移所致，AST和ALT≤5倍ULN，血清白蛋白（ALB）≥2.8g/dL；", "label": 5, "label_text": "Multiple", "id": "s1426"}
{"text": " 7．无法合作者，如精神病患者。", "label": 5, "label_text": "Multiple", "id": "s1427"}
{"text": " 4.由于自身各种原因不能配合完成治疗及定期随访的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1428"}
{"text": "      c. 髂内动脉直径在6-10mm之间；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1429"}
{"text": " 2.伴机械性消化道梗阻患者；", "label": 4, "label_text": "Disease", "id": "s1430"}
{"text": "①术前3月内急性肺损伤或急性呼吸窘迫综合征病史；", "label": 4, "label_text": "Disease", "id": "s1431"}
{"text": " ⑤心脏起搏器置入患者", "label": 34, "label_text": "Device", "id": "s1432"}
{"text": " 7. 妊娠或哺乳期或计划在一年内怀孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1433"}
{"text": " （6）认知损害与睡眠障碍相关；", "label": 4, "label_text": "Disease", "id": "s1434"}
{"text": " （4）研究对象配偶精液检查正常或经精液预洗后达到常规IVF或ICSI标准,或研究者配偶无精子而采用供精助孕。", "label": 5, "label_text": "Multiple", "id": "s1435"}
{"text": " 19)合并有以下CYP3A4、P-gp或Bcrp的抑制剂或诱导剂，如伊曲康唑、酮康唑或决奈达隆等。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1436"}
{"text": " （3）年龄12-45周岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1437"}
{"text": "近1年来经采用常规方法治疗后多次复查仍为阳性的霉菌性阴道炎患者作为研究对象；", "label": 5, "label_text": "Multiple", "id": "s1438"}
{"text": " 　　(1)病理学异常。或", "label": 11, "label_text": "Diagnostic", "id": "s1439"}
{"text": " 4）有正常的智力水平,可准确地理解整个实验中的动作指令；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s1440"}
{"text": " （4）系统性红斑狼疮（SLE）、皮肌炎等有紫外线治疗禁忌证者；", "label": 4, "label_text": "Disease", "id": "s1441"}
{"text": " 10）1月内有持续全身皮质激素治疗史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1442"}
{"text": " （6）汗密尔顿抑郁量表（HAMD-24）评分﹤8分；", "label": 9, "label_text": "Risk Assessment", "id": "s1443"}
{"text": " 3.伴有其他肿瘤病史者；", "label": 4, "label_text": "Disease", "id": "s1444"}
{"text": " 明显的括约肌障碍", "label": 4, "label_text": "Disease", "id": "s1445"}
{"text": " 5.患者神志清楚，能够正确理解和使用长海痛尺表达疼痛程度。", "label": 1, "label_text": "Sign", "id": "s1446"}
{"text": " （4）受试者体力状况KPS评分≥60分；", "label": 9, "label_text": "Risk Assessment", "id": "s1447"}
{"text": "（1）本市户籍常驻人口，或本地居住3年或以上；", "label": 40, "label_text": "Address", "id": "s1448"}
{"text": "(1)目前患有严重的心脑血管、造血系统疾病、恶性肿瘤等严重危及生命疾病的患者；", "label": 4, "label_text": "Disease", "id": "s1449"}
{"text": "1.有严重的脏器功能障碍或疾病，如心脏、肝脏、肾脏和胰腺等严重疾病和功能障碍者；", "label": 5, "label_text": "Multiple", "id": "s1450"}
{"text": " ② 重症急性胰腺炎（APACHEII≥8分，或Ranson≥3分，或CT Balthazar D、E级）；", "label": 4, "label_text": "Disease", "id": "s1451"}
{"text": " 2.已使用影响葡萄糖代谢及胰岛素分泌药物的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1452"}
{"text": " G)肝、肾功能异常（肝ALT、AST值异常，或肌酐、尿素氮值超一倍以上）；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1453"}
{"text": "?患者患有免疫系统疾病，如HIV病毒感染、自身免疫系统疾病等", "label": 4, "label_text": "Disease", "id": "s1454"}
{"text": " (8)妊娠期或者哺乳期女性，未采取避孕措施的育龄期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1455"}
{"text": " （6）不能进行充分术前准备的急诊患儿；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1456"}
{"text": " （5）签署知情同意书，自愿参加本项研究。", "label": 13, "label_text": "Consent", "id": "s1457"}
{"text": " 3.具有造血干细胞移植指征但无HLA相合同胞或无关供者；或病情要求尽快移植而无寻找HLA相合供者机会", "label": 5, "label_text": "Multiple", "id": "s1458"}
{"text": " 5)预计置入支架总数目>3枚或＞2支病变(每支病变狭窄≥50%)或同一血管病变置入支架＞2枚；", "label": 34, "label_text": "Device", "id": "s1459"}
{"text": " 10.临床医生认为不适宜受试的其他患者", "label": 21, "label_text": "Researcher Decision", "id": "s1460"}
{"text": " 2.未获得知情同意者。", "label": 13, "label_text": "Consent", "id": "s1461"}
{"text": " 2)接受常规胃镜诊疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1462"}
{"text": " 11.无法合作者，如精神病患者；", "label": 5, "label_text": "Multiple", "id": "s1463"}
{"text": " 4．脑内多发占位或复发颅内肿瘤；", "label": 4, "label_text": "Disease", "id": "s1464"}
{"text": " 3. 身体健康。", "label": 32, "label_text": "Healthy", "id": "s1465"}
{"text": " ④重大头颅外伤史；", "label": 4, "label_text": "Disease", "id": "s1466"}
{"text": " 4.凝血功能异常（INR>1.5、APTT>1.5 ULN），具有出血倾向者；", "label": 5, "label_text": "Multiple", "id": "s1467"}
{"text": " 4、有严重过敏史的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s1468"}
{"text": "（1）年龄＞20岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s1469"}
{"text": " –总胆红素在正常限值内；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1470"}
{"text": "①年龄18-70岁", "label": 3, "label_text": "Age", "id": "s1471"}
{"text": " 7. 符合临床研究伦理委员会要求。", "label": 43, "label_text": "Ethical Audit", "id": "s1472"}
{"text": " 11.顽固性或持续性癫痫患者；", "label": 4, "label_text": "Disease", "id": "s1473"}
{"text": " 11.有出血倾向者或3个月内发生过严重出血者；", "label": 1, "label_text": "Sign", "id": "s1474"}
{"text": " (2)治疗结束时，通过牙周治疗，牙周达到健康,即牙龈颜色正常，探诊不出血;", "label": 5, "label_text": "Multiple", "id": "s1475"}
{"text": " ? 确诊为原发性肝细胞癌HCC；", "label": 11, "label_text": "Diagnostic", "id": "s1476"}
{"text": " 5.近期有消化道出血史。", "label": 1, "label_text": "Sign", "id": "s1477"}
{"text": " 5.肺动脉高压、右心功能不全", "label": 5, "label_text": "Multiple", "id": "s1478"}
{"text": " 6、患有无法参加运动的神经肌肉骨骼疾病；", "label": 4, "label_text": "Disease", "id": "s1479"}
{"text": " (2)首次发病，卒中后30—60d，病情平稳无进展者；", "label": 4, "label_text": "Disease", "id": "s1480"}
{"text": " 3.术前有患侧腹股沟区的神经病理学改变，手术史或髋部手术史或创伤史，或双侧腹股沟区感觉不对称者；", "label": 5, "label_text": "Multiple", "id": "s1481"}
{"text": " （5）2周内未使用激素、茶碱类药物或β2受体激动剂。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1482"}
{"text": " 4）自愿签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s1483"}
{"text": " 5、术后CT平扫蛛网膜下腔出血、病灶内出血（HT2,PH1,PH2型）或远隔区域出血。", "label": 1, "label_text": "Sign", "id": "s1484"}
{"text": " 3）心律失常患者", "label": 4, "label_text": "Disease", "id": "s1485"}
{"text": " 2.证候选择参照《中医病症诊断疗效标准》中四弯风诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s1486"}
{"text": " （2）既往有麻醉手术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1487"}
{"text": " ④能独立完成运动训练的患者；", "label": 17, "label_text": "Capacity", "id": "s1488"}
{"text": " 7.术中需要血液稀释或低温。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1489"}
{"text": " 4.自愿参加本临床试验并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s1490"}
{"text": " （2） 影响缺血心肌总负荷评价的其他原因，如心肌肥厚、左束支传导阻滞、洋地黄药物影响、电解质紊乱等；", "label": 5, "label_text": "Multiple", "id": "s1491"}
{"text": " ③病情稳定,即患者咳嗽、咳痰、气短等症状稳定或症状轻微。", "label": 1, "label_text": "Sign", "id": "s1492"}
{"text": " 1. 血清学检测证实由肝炎病毒重叠感染、非病毒感染(如酒精性肝病)引起的慢性肝炎，或隐源型肝炎者；", "label": 11, "label_text": "Diagnostic", "id": "s1493"}
{"text": "1.有症状的脑转移、癌性脑膜炎（入组前21天已完成治疗且症状稳定的脑转移患者可以入组，但需经颅脑MRI、CT或静脉造影评价确认为无脑出血症状）；", "label": 5, "label_text": "Multiple", "id": "s1494"}
{"text": " (2)伴有严重合并症，全身情况不能耐受大型手术；", "label": 5, "label_text": "Multiple", "id": "s1495"}
{"text": "①患者患有外侧眶尖肿瘤，存在视力损失或即将发生视力损失；", "label": 4, "label_text": "Disease", "id": "s1496"}
{"text": " (6) 存在使用糖皮质激素禁忌患者。", "label": 4, "label_text": "Disease", "id": "s1497"}
{"text": " ○在最近一次治疗过程中或治疗结束后，疾病发生进展（PD）或发生复发（研究者根据2016版IMWG标准判断，附录A）;", "label": 11, "label_text": "Diagnostic", "id": "s1498"}
{"text": "1、病理证实为脑胶质瘤或PCNSL或TDLs，其中TDLs患者影像需符合：①T2WI最大病灶的最长直径≥20mm，②具有占位效应；", "label": 5, "label_text": "Multiple", "id": "s1499"}
{"text": "(1) 已明确晕厥病因的患者（如脑血管意外、恶性心律失常）；", "label": 4, "label_text": "Disease", "id": "s1500"}
{"text": " ?筛选期存在心动过缓（心率≤50次/分）、III度房室传导阻滞（不包括使用起搏器患者）等严重心律失常病史；", "label": 5, "label_text": "Multiple", "id": "s1501"}
{"text": " （6）年龄小于18岁", "label": 3, "label_text": "Age", "id": "s1502"}
{"text": " （14）研究者认为其不适合参加本试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s1503"}
{"text": "1. 无手术适应症", "label": 4, "label_text": "Disease", "id": "s1504"}
{"text": " 6.恶性肿瘤患者", "label": 4, "label_text": "Disease", "id": "s1505"}
{"text": " （4）美国东部肿瘤协作组（ECOG）体力状况（PS）评分≤2分；", "label": 9, "label_text": "Risk Assessment", "id": "s1506"}
{"text": " ?血清白蛋白<3.5 g/dL", "label": 12, "label_text": "Laboratory Examinations", "id": "s1507"}
{"text": " 2.经检查诊断为急性化脓性扁桃体炎、下呼吸道感染、急性鼻窦炎、结核、麻疹、百日咳、白喉者；", "label": 4, "label_text": "Disease", "id": "s1508"}
{"text": " 20 外周静脉通路较差者；", "label": 1, "label_text": "Sign", "id": "s1509"}
{"text": " 2) 病理组织学诊断为非小细胞肺癌，结合 CT 等影像学检查分型为中央型肺癌；", "label": 4, "label_text": "Disease", "id": "s1510"}
{"text": " （3）血小板＜50×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1511"}
{"text": " （2）HBsAg、HBVDNA阳性或肝组织学≥G2。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1512"}
{"text": " 严重肾功能异常（术前接受肾脏替代治疗者）；", "label": 5, "label_text": "Multiple", "id": "s1513"}
{"text": "（1）符合2型糖尿病诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s1514"}
{"text": "1.既往有神经精神疾病病史或意识障碍", "label": 4, "label_text": "Disease", "id": "s1515"}
{"text": " - 签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s1516"}
{"text": " 7.   肝功能child A或B级", "label": 9, "label_text": "Risk Assessment", "id": "s1517"}
{"text": "(1)  诊断明确的慢性丙型肝炎；", "label": 11, "label_text": "Diagnostic", "id": "s1518"}
{"text": "1. 有腹部手术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1519"}
{"text": " —总胆红素≤1.2×UNL，或者胆道支架放置引流通畅下≤3.0 × UNL", "label": 12, "label_text": "Laboratory Examinations", "id": "s1520"}
{"text": " 7)有器官移植病史。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1521"}
{"text": " ③排除脑白质营养不良症、婴儿型脊髓性肌萎缩、脊髓一小脑共济失调综合征、遗传代谢性疾病如苯丙酮尿症以及先天性克汀病、先天性脑积水等现代医学通过病因治疗、手术治疗可获显效的病人;", "label": 5, "label_text": "Multiple", "id": "s1522"}
{"text": "1)直肠癌、肛裂等严重肛肠病患者；", "label": 4, "label_text": "Disease", "id": "s1523"}
{"text": " 9.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1524"}
{"text": " （3）跟骨骨髓炎、跟骨结核、跟骨肿瘤和局部感染等；", "label": 4, "label_text": "Disease", "id": "s1525"}
{"text": "1、任何严重的或未控制的的系统性疾病（不稳定的呼吸,心脏、肝脏或肾脏疾病或其他内部的严重疾病或未控制的感染", "label": 4, "label_text": "Disease", "id": "s1526"}
{"text": " 2）任何与心血管疾病有关的症状患者；", "label": 4, "label_text": "Disease", "id": "s1527"}
{"text": " （6）营养不良至恶病质者；", "label": 4, "label_text": "Disease", "id": "s1528"}
{"text": " 4）、血压（含药物控制后）<180/110mmHg。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1529"}
{"text": "1精神活性药物导致的抑郁；", "label": 5, "label_text": "Multiple", "id": "s1530"}
{"text": " （6）肥胖（BMI＞30kgm-2）；", "label": 5, "label_text": "Multiple", "id": "s1531"}
{"text": " 2. 合并肝衰竭、肝硬化（纤维化S4及以上）、肝性脑病、水电解质及酸碱平衡紊乱、消化道出血、感染及其他慢性乙肝严重并发症者；", "label": 5, "label_text": "Multiple", "id": "s1532"}
{"text": " 2.首诊患者，病检明确为口腔癌。", "label": 11, "label_text": "Diagnostic", "id": "s1533"}
{"text": " 4、实施肝移植手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1534"}
{"text": "（1）因单侧髋部骨折（股骨颈骨折、股骨转子间及转子下骨折）行手术治疗患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1535"}
{"text": " 2）有皮肤过敏、湿疹、细菌感染、真菌感染等皮肤病患者；", "label": 4, "label_text": "Disease", "id": "s1536"}
{"text": " 2.自报患有心脑肾肝、呼吸系统、血液系统等疾病，且不耐受运动者；", "label": 5, "label_text": "Multiple", "id": "s1537"}
{"text": " 9.根据研究者的判断，有严重的危害患者安全、或影响患者完成研究的伴随疾病；", "label": 21, "label_text": "Researcher Decision", "id": "s1538"}
{"text": " 未签署书面知情同意书", "label": 13, "label_text": "Consent", "id": "s1539"}
{"text": " 5) 签署知情同意，同意参加本项研究。", "label": 13, "label_text": "Consent", "id": "s1540"}
{"text": " （5）脑器质性疾病和其他严重躯体疾病；", "label": 4, "label_text": "Disease", "id": "s1541"}
{"text": " ④自愿接受三伏贴治疗并签署知情同意书", "label": 5, "label_text": "Multiple", "id": "s1542"}
{"text": " 3、肠镜检查必须到达盲肠，所有未达盲肠的患者均不入选。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1543"}
{"text": " 2、ARB类药物过敏（治疗组）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1544"}
{"text": " (5)无主要脏器疾病史；", "label": 4, "label_text": "Disease", "id": "s1545"}
{"text": " 7) 缺血性心脏病急性期的患者", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1546"}
{"text": " ⑥凝血功能不全的患者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1547"}
{"text": " 6.筛选前三个月内献血达360ml或以上；", "label": 14, "label_text": "Blood Donation", "id": "s1548"}
{"text": " 3. 糖皮质激素或免疫抑制剂使用者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1549"}
{"text": " ⑤ 未按疗程完成内分泌治疗，无法判定疗效者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1550"}
{"text": " 5)能配合临床观察者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s1551"}
{"text": " 4.ECOG评分 ≤2分（评分标准见附录2）；", "label": 9, "label_text": "Risk Assessment", "id": "s1552"}
{"text": " 7. 1个月内新发心肌梗死；", "label": 4, "label_text": "Disease", "id": "s1553"}
{"text": " ④初诊视觉模拟量表（VAS）评分大于3分小于7分（范围为0-10分）；", "label": 9, "label_text": "Risk Assessment", "id": "s1554"}
{"text": " 3.体格检查生殖系统无器质性病变，例如：输精管缺失或梗阻、睾丸缺失、睾丸体积小于12ml或任何睾丸位置异常", "label": 4, "label_text": "Disease", "id": "s1555"}
{"text": " 15.在过去 5 年中发生过任何器官系统肿瘤史者；", "label": 4, "label_text": "Disease", "id": "s1556"}
{"text": " 5、严重的肝脏疾病。定义为：试验前28 天内SGPT/ALT，SGOT/AST 或者总胆红素持续升高，超过正常值2倍以上", "label": 5, "label_text": "Multiple", "id": "s1557"}
{"text": " ④近1个月内未使用任何口服药物治疗本病的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1558"}
{"text": " 4、继发于明显出血的心脏骤停（如主动脉瘤破裂、消化道大出血）", "label": 4, "label_text": "Disease", "id": "s1559"}
{"text": " 3) 全身健康状况良好，没有长期服用药物史，没有参加其他项目；", "label": 5, "label_text": "Multiple", "id": "s1560"}
{"text": " ⑵慢性肾脏病1期及3期以上（eGFR≥90ml/min/1.73m2及eGFR＜60ml/min/1.73m2）；", "label": 5, "label_text": "Multiple", "id": "s1561"}
{"text": " ⑥同时服用镇静药物，可能对治疗效果造成影响者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1562"}
{"text": " 6.孕妇或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1563"}
{"text": " （2）按体重指数＝体重（kg）／身高2（m2）计算,在19～24范围内；", "label": 9, "label_text": "Risk Assessment", "id": "s1564"}
{"text": " （7) 满足手术及麻醉要求。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1565"}
{"text": " ⑥无法完成手术前的神经心理测试。", "label": 17, "label_text": "Capacity", "id": "s1566"}
{"text": " 5)血象、心、肺、肝、肾等主要器官功能基本正常。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1567"}
{"text": " 8. 随访3月之前失访", "label": 8, "label_text": "Compliance with Protocol", "id": "s1568"}
{"text": "入选时有心力衰竭、呼吸衰竭、中毒性脑病、渗出性胸膜炎等合并症者。", "label": 4, "label_text": "Disease", "id": "s1569"}
{"text": " 9.已经发生中枢神经系统转移或已知的脑转移患者；", "label": 24, "label_text": "Neoplasm Status", "id": "s1570"}
{"text": " - 签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s1571"}
{"text": " 8.凝血功能异常（INR>1.5、APTT>1.5 ULN）具有出血倾向者，或者12个月内发生过动/静脉血栓事件者；", "label": 5, "label_text": "Multiple", "id": "s1572"}
{"text": " 3休克、生命体征不稳定、消化性溃疡或出血、严重心肺并发症、肝肾功能障碍、晚期癌症；", "label": 5, "label_text": "Multiple", "id": "s1573"}
{"text": " 3.有临床意义的肝损害（ALT或ALP≥正常上限2.5倍）；", "label": 5, "label_text": "Multiple", "id": "s1574"}
{"text": " 2.不同意参加研究", "label": 13, "label_text": "Consent", "id": "s1575"}
{"text": " 组1：未曾使用任何丹参类制剂（包括注射用丹参多酚酸）；曾使用过丹参类制剂（包括注射用丹参多酚酸），未发生过过敏反应者；曾使用过丹参类制剂（包括注射用丹参多酚酸），发生过过敏反应者；曾发生过药物过敏反应者；并自愿知情同意参加受试。", "label": 5, "label_text": "Multiple", "id": "s1576"}
{"text": "1,局麻药过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1577"}
{"text": " （2）面肌联动患者：患者有明显的面肌联动，未进行手术治疗。", "label": 5, "label_text": "Multiple", "id": "s1578"}
{"text": " 3、年龄在50-70岁之间者；", "label": 3, "label_text": "Age", "id": "s1579"}
{"text": " 3. 拟行黄体期长方案助孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1580"}
{"text": " 2. 超重肥胖2型糖尿病诊断标准：在满足上述条件之一且BMI≥24.0kg/m2者;", "label": 5, "label_text": "Multiple", "id": "s1581"}
{"text": "1）膝骨关节炎KL分级4级", "label": 9, "label_text": "Risk Assessment", "id": "s1582"}
{"text": " 17)自筛选开始半年内有生育意向的男性和女性；", "label": 5, "label_text": "Multiple", "id": "s1583"}
{"text": " c) 在过去6个月内参加过I、II期临床试验或者3个月内参加过III、IV期临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1584"}
{"text": " 2)肝硬化严重，肝功能差Child-Pugh C级；", "label": 5, "label_text": "Multiple", "id": "s1585"}
{"text": " 7.其他研究者认为不适合入组的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s1586"}
{"text": " 6. 突发其他急性疾病者；", "label": 4, "label_text": "Disease", "id": "s1587"}
{"text": " 4、认知受损或严重智力缺陷。", "label": 4, "label_text": "Disease", "id": "s1588"}
{"text": " ⑩研究人员认为其他原因不适合临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s1589"}
{"text": " （3） 2周内接受过抗疟治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1590"}
{"text": " 4）没有清洁舌苔的习惯；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s1591"}
{"text": " 6、自愿参加本实验, 与有知情能力的患者或（和）监护人签署同意书。", "label": 13, "label_text": "Consent", "id": "s1592"}
{"text": " 7.慢性胃病史", "label": 4, "label_text": "Disease", "id": "s1593"}
{"text": " 11）患有其他未被控制的疾病，研究者认为不适合加入者；", "label": 5, "label_text": "Multiple", "id": "s1594"}
{"text": " 5）在筛选前1个月内服用了任何改变肝酶活性的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1595"}
{"text": "1. 不愿意接受调查、检查者；", "label": 13, "label_text": "Consent", "id": "s1596"}
{"text": " 6）试验前4周内患过具有临床意义的重大疾病或接受过重大外科手术者；", "label": 5, "label_text": "Multiple", "id": "s1597"}
{"text": "（1） 首次冠脉介入治疗术后成功的急性冠脉综合征患者；", "label": 5, "label_text": "Multiple", "id": "s1598"}
{"text": " 8)未能得到良好控制的顽固性高血压（收缩压≥180mmHg，或舒张压≥105mmHg）；", "label": 5, "label_text": "Multiple", "id": "s1599"}
{"text": " 3）假性延髓性麻痹伴吞咽困难者；", "label": 28, "label_text": "Symptom", "id": "s1600"}
{"text": " 2)已知对沙库巴曲缬沙坦钠、阿利沙坦酯、氯沙坦、缬沙坦等血管紧张素II受体拮抗剂及本品辅料有过敏反应者；或过敏体质（多种药物及食物过敏）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1601"}
{"text": " 2. 年龄：18-75岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1602"}
{"text": " 2. 年龄18-65岁(包括18和65周岁)，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1603"}
{"text": " （2）孕37-41周", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1604"}
{"text": " （10）总胆红素≤1.5倍正常参考值上限", "label": 12, "label_text": "Laboratory Examinations", "id": "s1605"}
{"text": " 3) 体重指数(BMI)在19-25 kg/m2范围内，[BMI=体重（kg）/身高（m2）]；", "label": 9, "label_text": "Risk Assessment", "id": "s1606"}
{"text": " （2）记忆功能异常的客观证据；", "label": 11, "label_text": "Diagnostic", "id": "s1607"}
{"text": " 8. 有明显出血倾向及血液系统疾病者（血小板计数低于50或INR>1.5）；", "label": 5, "label_text": "Multiple", "id": "s1608"}
{"text": " 11）精神病患者；", "label": 4, "label_text": "Disease", "id": "s1609"}
{"text": " 6. 签署接受手术的书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s1610"}
{"text": " 2.存在可能导致严重出血的疾病", "label": 4, "label_text": "Disease", "id": "s1611"}
{"text": " 9 近一月内进行肠内外营养制剂治疗及近一周内暴饮暴食；", "label": 18, "label_text": "Diet", "id": "s1612"}
{"text": "①临床诊断为晚期癌症患者；", "label": 11, "label_text": "Diagnostic", "id": "s1613"}
{"text": " 6）妊娠期或哺乳期；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1614"}
{"text": " 4.正在接受任意剂量的伊马替尼治疗，尚未出现治疗失败和耐药；或正在接受任意剂量的第二代TKI（尼洛替尼、达沙替尼、帕纳替尼或伯舒替尼）治疗", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1615"}
{"text": " ③.膀胱灌注治疗过程出现严重的副作用而不能耐受者（膀胱刺激症状等）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1616"}
{"text": " ③ 患有急性中枢神经系统疾病、严重胃肠道疾病、HIV感染史、精神病史、恶性肿瘤病史患者；", "label": 4, "label_text": "Disease", "id": "s1617"}
{"text": " (3). 严重心、肝、肾、造血功能异常，或合并肺炎、严重全身感染者；", "label": 5, "label_text": "Multiple", "id": "s1618"}
{"text": " (4).跟腱损伤", "label": 4, "label_text": "Disease", "id": "s1619"}
{"text": " (4)美国麻醉医师协会（ASA）分级为I~ II级；", "label": 9, "label_text": "Risk Assessment", "id": "s1620"}
{"text": "1)确诊为2型糖尿病，糖化血糖蛋白和空腹血糖异常的患者；糖化血红蛋白以及空腹血糖正常的患者，尿蛋白检测为阴性；", "label": 4, "label_text": "Disease", "id": "s1621"}
{"text": " 5. 合并心、肺、肝、肾等重要脏器的功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1622"}
{"text": " (3)年龄≥18岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s1623"}
{"text": " 2.其委托家属有能力并愿意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1624"}
{"text": " 至少一位家长同意参与本项目。", "label": 13, "label_text": "Consent", "id": "s1625"}
{"text": " 4）有远处转移者；", "label": 24, "label_text": "Neoplasm Status", "id": "s1626"}
{"text": " 5.有体位性低血压病史、头晕或眩晕史", "label": 4, "label_text": "Disease", "id": "s1627"}
{"text": " 7.妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1628"}
{"text": " 2.肝脏、肺、骨、等远处转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s1629"}
{"text": " 2、因各种原因导致长期（持续一个月）服用镇静类、止痛类及神经精神类药物病史者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1630"}
{"text": " (3)合并恶性肿瘤或其他严重疾病，生存预期小于3月。", "label": 5, "label_text": "Multiple", "id": "s1631"}
{"text": " ⑧按WHO的肥胖分级: I级肥胖患者以上者", "label": 11, "label_text": "Diagnostic", "id": "s1632"}
{"text": " 2.心功能不稳定，NYHA心功能分级为IV级的患者，植入起搏器、ICD的患者，近三个月内进行心脏手术的患者。", "label": 5, "label_text": "Multiple", "id": "s1633"}
{"text": " 4.患者为首次发病，或既往肢体瘫痪后遗症不影响神经功能评分的再次发病患者。", "label": 4, "label_text": "Disease", "id": "s1634"}
{"text": " 4. 在海平面状态下，静息时多普勒超声心动图估测三尖瓣峰值流速＞3m/s或肺动脉收缩压＞40mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1635"}
{"text": " 2、有近期血栓病史；", "label": 4, "label_text": "Disease", "id": "s1636"}
{"text": " (7)自愿参加本研究，并签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s1637"}
{"text": " 2.年龄在35～75岁；", "label": 3, "label_text": "Age", "id": "s1638"}
{"text": " ②自愿签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s1639"}
{"text": " 11)3个月内参加过其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1640"}
{"text": " 5)凝血功能：PT≤正常上限1.5倍；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1641"}
{"text": " 12.妊娠、哺乳期或计划在试验期间怀孕的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1642"}
{"text": "男性或女性，18到75岁，无并发症的轻度到中度原发性高血压患者。", "label": 5, "label_text": "Multiple", "id": "s1643"}
{"text": " 6.妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1644"}
{"text": " （2）之前接受过手术导致眼球施莱姆氏管上产生疤痕者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1645"}
{"text": " 3.有精神疾病等、预期会导致依从性不良的患者", "label": 5, "label_text": "Multiple", "id": "s1646"}
{"text": " 2、平素坚持运动者", "label": 27, "label_text": "Exercise", "id": "s1647"}
{"text": "1. 左室射血分数<40%，或中重度左室肥厚(左室壁厚度＞15mm)", "label": 12, "label_text": "Laboratory Examinations", "id": "s1648"}
{"text": " ⑤颈椎椎管狭窄、颈椎椎管内占位性病变等。", "label": 4, "label_text": "Disease", "id": "s1649"}
{"text": " f) 受试者自愿参加试验并愿意按照本试验规定的程序进行试验；", "label": 13, "label_text": "Consent", "id": "s1650"}
{"text": " ④　合并严重骨质疏松、糖尿病、下肢血管疾病、肢体畸形、神经系统疾病的患者；", "label": 4, "label_text": "Disease", "id": "s1651"}
{"text": " 4.有机械通气的病人", "label": 38, "label_text": "Nursing", "id": "s1652"}
{"text": " （2）近3月内使用除激素以外的免疫抑制剂者（包括FK506、MMF、环磷酰胺、环孢素A等）", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1653"}
{"text": " 8 全身已发生广泛转移者或伴有其他恶性肿瘤病史；", "label": 4, "label_text": "Disease", "id": "s1654"}
{"text": " 13. 血肌酐＜正常上界1.5倍", "label": 12, "label_text": "Laboratory Examinations", "id": "s1655"}
{"text": " 12)其他经研究者判定不符合入选条件的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s1656"}
{"text": "（1）年龄≥65岁。", "label": 3, "label_text": "Age", "id": "s1657"}
{"text": "1)18岁以上成人，非怀孕非哺乳期妇女。", "label": 5, "label_text": "Multiple", "id": "s1658"}
{"text": " 3）临床表现明显的脏器水肿(特别是急性肺水肿，急性左心衰)；", "label": 5, "label_text": "Multiple", "id": "s1659"}
{"text": " 2、明确膀胱癌诊断 (T2-T4a)；", "label": 11, "label_text": "Diagnostic", "id": "s1660"}
{"text": " 4.急危重症无法完成监护的高危孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1661"}
{"text": " 3)血常规指标：中性粒细胞≥1.5*109，血小板≥100*109，血红蛋白≥90g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1662"}
{"text": " ③  PSA：PSA > 3 ng/ml, fPSA/tPSA < 0.16;", "label": 12, "label_text": "Laboratory Examinations", "id": "s1663"}
{"text": "（1）年龄20～45岁，有生育要求；", "label": 5, "label_text": "Multiple", "id": "s1664"}
{"text": " 2. 1-5处转移灶，可为非区域淋巴结转移、骨转移或内脏转移。", "label": 24, "label_text": "Neoplasm Status", "id": "s1665"}
{"text": " ③影像学资料和临床表现一致", "label": 5, "label_text": "Multiple", "id": "s1666"}
{"text": " 9.严重肝、肾功能异常者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1667"}
{"text": " 7.伴发有精神类疾病者；", "label": 4, "label_text": "Disease", "id": "s1668"}
{"text": " 4.医生认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s1669"}
{"text": " 3．根据研究者判断，患有严重或不稳定的缺血性心脏病、心律失常、心肌病、心力衰竭、控制不良的高血压，或其它心血管疾病的患者。", "label": 4, "label_text": "Disease", "id": "s1670"}
{"text": " （5）合并有心脑血管、肝肾和造血系统等严重原发性疾病者；", "label": 4, "label_text": "Disease", "id": "s1671"}
{"text": " 16)文盲", "label": 41, "label_text": "Education", "id": "s1672"}
{"text": " （4）恶性肿瘤或患者预期寿命少于3年；", "label": 5, "label_text": "Multiple", "id": "s1673"}
{"text": " 11）妊娠期、哺乳期妇女及试验期间或服药停止后3个月内计划生育者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1674"}
{"text": " 2、确诊为急性淋巴细胞白血病（ALL），免疫分型为B前体淋巴细胞表型；", "label": 11, "label_text": "Diagnostic", "id": "s1675"}
{"text": " 5.脂肪肝、肝炎病毒携带者及肝功能异常者；", "label": 5, "label_text": "Multiple", "id": "s1676"}
{"text": " （4）能够使用本治疗方案坚持治疗者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1677"}
{"text": " 13.研究者经系统评价，判断不适合入组参加本研究的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s1678"}
{"text": " 6)病人对紫杉醇有过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1679"}
{"text": " ④ 无发热、肌肉疼痛、关节痛、纳差、全身不适等CMV综合征表现", "label": 28, "label_text": "Symptom", "id": "s1680"}
{"text": "1) 年龄≥18岁，≤65岁;", "label": 3, "label_text": "Age", "id": "s1681"}
{"text": " (3)对所需使用的麻醉药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1682"}
{"text": " 2. 严重肝实质病变，伴有明显的门静脉高压", "label": 4, "label_text": "Disease", "id": "s1683"}
{"text": " 6)合并其他感染（如单纯疱疹病毒、弓形虫等）；", "label": 4, "label_text": "Disease", "id": "s1684"}
{"text": "1、拟接受化疗的初治或复治的肺癌、胃癌等患者，有明确的病理学诊断，拟接受含顺铂的3日化疗；", "label": 11, "label_text": "Diagnostic", "id": "s1685"}
{"text": " 2) 行择期心脏手术患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1686"}
{"text": " –谷丙转氨酶和谷草转氨酶≤2.5倍正常值上限；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1687"}
{"text": "1.年满18岁的男性或女性", "label": 5, "label_text": "Multiple", "id": "s1688"}
{"text": " 15. alcohol abuse and drug addiction.", "label": 5, "label_text": "Multiple", "id": "s1689"}
{"text": " 18.经询问，吸烟超过5支/日或等量烟草者。", "label": 36, "label_text": "Smoking Status", "id": "s1690"}
{"text": " （3）肝硬化失代偿期患者；", "label": 4, "label_text": "Disease", "id": "s1691"}
{"text": " （8）实验开始前两周停用任何益生菌制剂", "label": 18, "label_text": "Diet", "id": "s1692"}
{"text": " 4.肝功能失代偿期肝硬化及肝脏恶性肿瘤患者", "label": 4, "label_text": "Disease", "id": "s1693"}
{"text": " （4）物质、药物滥用史，及严重自杀、伤人倾向的患者；", "label": 5, "label_text": "Multiple", "id": "s1694"}
{"text": " ⑥1月内使用任何含与本药相同成分制剂者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1695"}
{"text": "（1）患者及其法定代理人自愿参加研究，且签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s1696"}
{"text": " 2)其他视神经疾病：压迫性及浸润性、感染性、外伤性、中毒及营养代谢性、遗传性等。", "label": 4, "label_text": "Disease", "id": "s1697"}
{"text": " （5）有活动性病毒或细菌感染，且未能通过治疗控制；", "label": 5, "label_text": "Multiple", "id": "s1698"}
{"text": "①. 年龄大于等于18岁，且小于70岁的女性患者", "label": 5, "label_text": "Multiple", "id": "s1699"}
{"text": " (2) 初始测定P/F≤150mmHg的患者（血气分析的测定条件如①），暂不存在紧急气管插管的指征，先给予无创正压通气支持（根据临床医生的经验设置模式及参数，使SPO2维持在88%～92%）4h，然后在CPAP≥5cmH2O或者EPAP≥5cmH2O的条件下，重复测定动脉血气分析，150mmHg＜P/F≤300mmHg", "label": 5, "label_text": "Multiple", "id": "s1700"}
{"text": "1.术前诊断中下段食管癌", "label": 11, "label_text": "Diagnostic", "id": "s1701"}
{"text": " 2. 有中枢神经系统（CNS）转移的证据，如果怀疑有CNS转移，患者应在入组前28天内进行扫描MRI或增强CT扫描以排除。", "label": 5, "label_text": "Multiple", "id": "s1702"}
{"text": " 6)Karnofsky评分≥70；", "label": 9, "label_text": "Risk Assessment", "id": "s1703"}
{"text": " ?签署知情同意书，方案依从性好。", "label": 5, "label_text": "Multiple", "id": "s1704"}
{"text": " 8.凝血功能异常（INR>1.5、APTT>1.5 UNL），具有出血倾向；", "label": 5, "label_text": "Multiple", "id": "s1705"}
{"text": " 12、乙肝表面抗原（HBsAg）、丙肝抗体（HCV-Ab）、获得性免疫综合征抗体（Anti-HIV）及抗梅毒螺旋体抗体（TP-Ab）任意一项阳性者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s1706"}
{"text": " 2、位于幕上的慢性硬膜下血肿患者；", "label": 4, "label_text": "Disease", "id": "s1707"}
{"text": " 4.有放疗/射频消融治疗禁忌症，无法完成治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s1708"}
{"text": " 14)伴严重并发症者，如活动性消化道大出血、穿孔、黄疸、胃肠梗阻、活动性的严重临床感染（ > 2 级感染标准）者；", "label": 4, "label_text": "Disease", "id": "s1709"}
{"text": " 8)具有影响口服药物的多种因素（比如无法吞咽、慢性腹泻和肠梗阻等）者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1710"}
{"text": " （2）入选前5天内使用过影响胃肠动力或胃酸分泌、中和胃酸的药物、抗幽门螺杆菌药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1711"}
{"text": " 5、发病前改良RANKIN量表评分为0～1分。", "label": 9, "label_text": "Risk Assessment", "id": "s1712"}
{"text": " 5)正在使用针对关节健康的营养补充剂。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1713"}
{"text": " （8）ALT、AST、Cr大于正常值上限者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1714"}
{"text": " 2.妊娠或哺乳期的妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1715"}
{"text": " 2)心律失常需要接受抗心律失常治疗，症状性冠心病或心肌缺血（近6个月内发生心肌梗塞）或充血性心力衰竭超过NYHA Ⅱ级；接受过2种或以上抗高血压治疗仍未能控制的高血压（收缩压>160 mmHg或舒张压>100 mmHg）；", "label": 5, "label_text": "Multiple", "id": "s1716"}
{"text": " （2）确诊为ADPKD的患者（诊断标准：主要根据家族遗传史、影像学检查和基因检测确立诊断。有家族遗传史者，30岁以下者超声检查单侧或双侧有2个囊肿；30～59岁者双侧肾脏囊肿至少各2个；60岁以上患者双侧肾脏囊肿至少各4个；如果同时具有其他ADPKD表现，如肝囊肿等，诊断标准可适当放宽。无家族史者，除影像学诊断外，应同时行基因诊断）", "label": 5, "label_text": "Multiple", "id": "s1717"}
{"text": " ③近期有感染、手术史、急性心脑血管疾病史者；", "label": 5, "label_text": "Multiple", "id": "s1718"}
{"text": " 4、过敏体质及多种药物过敏史", "label": 7, "label_text": "Allergy Intolerance", "id": "s1719"}
{"text": " 2) 有显著的消化道功能异常，可能影响口服药物的摄入、转运或吸收（如无法吞咽、慢性腹泻、肠梗阻等）；", "label": 5, "label_text": "Multiple", "id": "s1720"}
{"text": " 1）所患疾病会造成治疗和评价困难（如中风、严重感染性疾病、严重的心脏疾患、传染性疾病如肝炎、严重代谢性疾病、精神疾病、癫痫疾病、或药物滥用、酒精依赖者等）；", "label": 5, "label_text": "Multiple", "id": "s1721"}
{"text": " ② 严重钙化病变患者；", "label": 4, "label_text": "Disease", "id": "s1722"}
{"text": " （5）患者有活动性乙肝，丙肝，HIV或者梅毒等病毒及细菌真菌感染；", "label": 4, "label_text": "Disease", "id": "s1723"}
{"text": " (3)有精神疾患者;", "label": 4, "label_text": "Disease", "id": "s1724"}
{"text": " 3) 证实心房内血栓，肿瘤，或其他可能妨碍导管放置的疾病", "label": 4, "label_text": "Disease", "id": "s1725"}
{"text": " ⑤存在严重心肺肝肾功能异常及合并免疫系统疾病，内分泌免疫系统疾病或者可能干扰实验结果的任何其他疾病或病理情况", "label": 5, "label_text": "Multiple", "id": "s1726"}
{"text": " 2 血液系统疾病高危粒缺伴发热患者（诊断标准参照IDSA发热伴中性粒细胞缺乏患者治疗指南2010版)", "label": 11, "label_text": "Diagnostic", "id": "s1727"}
{"text": " 6.入选前三个月内，参加过另一药物试验或使用过本试验药物；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1728"}
{"text": " 2)术前血小板 < 50×109/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s1729"}
{"text": " 2．年龄在18-65岁的ICU住院病人", "label": 5, "label_text": "Multiple", "id": "s1730"}
{"text": " 5.4.活动性乙型肝炎病毒(HBV，Hepatitis B Virus)、丙型肝炎病毒（HCV，Hepatitis C Virus）和艾滋病病毒（HIV, Human Immunodeficiency Virus）感染；", "label": 4, "label_text": "Disease", "id": "s1731"}
{"text": "1)择期全麻手术患者，ASA I-II级；", "label": 5, "label_text": "Multiple", "id": "s1732"}
{"text": "1. 根治手术后，病理确诊腺癌；", "label": 5, "label_text": "Multiple", "id": "s1733"}
{"text": " 2. 孕妇或哺乳期病人；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1734"}
{"text": "1.按照维也纳诊断标准  诊断为MDS，包括难治性贫血（RA）、难治性血细胞减少伴有单系发育异常（RCUD）、难治性血细胞减少伴有多系发育异常（RCMD）三种类型。并按照IPSS评分，0-1分的中低危组患者。", "label": 5, "label_text": "Multiple", "id": "s1735"}
{"text": " b)哺乳期女性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1736"}
{"text": "①人工荨麻疹合并其它类型的荨麻疹", "label": 4, "label_text": "Disease", "id": "s1737"}
{"text": " --本人同意参加本研究并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1738"}
{"text": " 5.影像学与/或临床体格检查证实疼痛和日常生活活动受限为膝关节病变所致。", "label": 11, "label_text": "Diagnostic", "id": "s1739"}
{"text": " -血小板≥90×109/L，", "label": 12, "label_text": "Laboratory Examinations", "id": "s1740"}
{"text": " 2）明确诊断为先天性心脏病（房间隔缺损、室间隔缺损、动脉导管未闭及其他复杂先心病）合并非心脏畸形（腹股沟斜疝、鞘膜积液、隐睾、尿道下裂及其他复杂非心脏畸形）的患儿；", "label": 5, "label_text": "Multiple", "id": "s1741"}
{"text": " 营养不良：MNA-SF评分0-7分", "label": 9, "label_text": "Risk Assessment", "id": "s1742"}
{"text": " 有MRI检查禁忌证者（心脏起搏器、幽闭恐惧症等）；", "label": 4, "label_text": "Disease", "id": "s1743"}
{"text": "1、年龄18~75周岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s1744"}
{"text": " 2）糖化血红蛋白在7.5-10%之间；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1745"}
{"text": " 7.肾脏替代治疗下的末期肾病.", "label": 4, "label_text": "Disease", "id": "s1746"}
{"text": " 4)签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1747"}
{"text": "A.患有其他精神障碍；", "label": 4, "label_text": "Disease", "id": "s1748"}
{"text": "1.自愿参加并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1749"}
{"text": "1.明确有脊柱、会阴部外伤史", "label": 4, "label_text": "Disease", "id": "s1750"}
{"text": " 2.术前X线及CT证实为骨质疏松型三、四部分肱骨近端骨折", "label": 11, "label_text": "Diagnostic", "id": "s1751"}
{"text": " e)排除其他视神经疾病。", "label": 4, "label_text": "Disease", "id": "s1752"}
{"text": " 2.根据诊断标准，病情属中度以上者；", "label": 11, "label_text": "Diagnostic", "id": "s1753"}
{"text": " 4. 脊髓解剖异常", "label": 4, "label_text": "Disease", "id": "s1754"}
{"text": " ③ 无严重心肺等疾病；", "label": 4, "label_text": "Disease", "id": "s1755"}
{"text": " 2. 符合维生素D缺乏症诊断标准血清25羟维生素D＜50nmol/L", "label": 5, "label_text": "Multiple", "id": "s1756"}
{"text": " 5 至少1个病灶(既往未接受过放疗)，基线时经CT准确测量显示其最长直径≥10mm（淋巴结除外，淋巴结的短轴必须≥15mm），且依照RECIST v1.1指南，该病灶适合反复准确测量；", "label": 5, "label_text": "Multiple", "id": "s1757"}
{"text": " 6）有严重过敏史者或有血液系统疾病史，服用干扰凝血功能的药物者；", "label": 5, "label_text": "Multiple", "id": "s1758"}
{"text": " (7) 有血液系统疾病失或有明显出血倾向者。", "label": 5, "label_text": "Multiple", "id": "s1759"}
{"text": " 1.5. 心肌及心包病变（如心肌淀粉样病变，肥厚型心肌病，限制性心肌病和缩窄性心包疾病）", "label": 4, "label_text": "Disease", "id": "s1760"}
{"text": " 盆腔器官脱垂为POP-Q（盆腔器官脱垂定量分期法）分期 III-IV度", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1761"}
{"text": "（1）既往有乙型肝炎病史或HBsAg阳性大于6个月；", "label": 5, "label_text": "Multiple", "id": "s1762"}
{"text": " （22）研究者认为有不宜入选的其它原因。", "label": 21, "label_text": "Researcher Decision", "id": "s1763"}
{"text": " 12.    合并或预计在研究期内使用肾毒性药物者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1764"}
{"text": "1)经体格检查血压、心电图、呼吸状况或生化检查、血尿常规、乙型肝炎表面抗原、丙型肝炎抗体、HIV异常（经临床医师判断有临床意义）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1765"}
{"text": "（1）1个月内治疗天疱疮的用药方案或剂量有改变者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1766"}
{"text": " 5. 血压控制不佳（BP ≥ 140/90mmHg 或服用三种或以上药物后血压仍 ≥ 160/100mmHg ）或静息心率 ≥ 100次/分", "label": 5, "label_text": "Multiple", "id": "s1767"}
{"text": " 3.签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1768"}
{"text": " 2、年龄在1～65岁；", "label": 3, "label_text": "Age", "id": "s1769"}
{"text": "1.停经时间≥12周", "label": 12, "label_text": "Laboratory Examinations", "id": "s1770"}
{"text": " ⑤痉挛者改良Ashworth评定瘫痪肢体肌张力0-3级；", "label": 9, "label_text": "Risk Assessment", "id": "s1771"}
{"text": " 2）一周内行膝关节初次全膝关节置换术治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s1772"}
{"text": " 5、无视觉感知障碍（例如：单侧忽略，偏盲，或失用）；", "label": 4, "label_text": "Disease", "id": "s1773"}
{"text": " 15、妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1774"}
{"text": " 3.合并内分泌系统疾病，如甲状腺机能亢进等；", "label": 4, "label_text": "Disease", "id": "s1775"}
{"text": " 13)研究者判断患者的情况不适合参加此试验研究。", "label": 21, "label_text": "Researcher Decision", "id": "s1776"}
{"text": " 4.能配合长期随访，并签署知情同意书者。", "label": 5, "label_text": "Multiple", "id": "s1777"}
{"text": "     预计手术时间≧60 min，65-80岁，性别不限", "label": 5, "label_text": "Multiple", "id": "s1778"}
{"text": " 3）存在超声可见的输卵管积水或已证实存在的子宫畸形及未纠正的宫腔病变", "label": 4, "label_text": "Disease", "id": "s1779"}
{"text": " 4.不能如期随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1780"}
{"text": " 3. 不能手术和放疗的晚期、复发或转移的头颈部恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s1781"}
{"text": " （5）有流产史或手术史或刮宫史；", "label": 5, "label_text": "Multiple", "id": "s1782"}
{"text": " C.膝关节内侧间隙软骨存在破坏（MRI显示）", "label": 11, "label_text": "Diagnostic", "id": "s1783"}
{"text": " (4)孕妇患有精神疾病者；", "label": 5, "label_text": "Multiple", "id": "s1784"}
{"text": " 3）发病前mRS≤2；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1785"}
{"text": " 6.难以控制的高血压（血压≥160/100mmHg）患者。。", "label": 4, "label_text": "Disease", "id": "s1786"}
{"text": " 4.病理性骨折所致病变（椎体转移瘤、骨髓瘤等）；", "label": 4, "label_text": "Disease", "id": "s1787"}
{"text": " 4.参试者能够按要求完成病例观察表等相关记录，按要求留取血液、粪便标本。", "label": 17, "label_text": "Capacity", "id": "s1788"}
{"text": " 2. 符合中华医学会呼吸病学分会制定《慢性阻塞性肺疾病诊治指南》（2007年修订版）诊断标准的慢性阻塞性肺疾病急性加重的患者", "label": 11, "label_text": "Diagnostic", "id": "s1789"}
{"text": " （2）造血系统明显异常（以血常规为筛查指标）；", "label": 11, "label_text": "Diagnostic", "id": "s1790"}
{"text": " 3.外侧间室软骨厚度完整", "label": 1, "label_text": "Sign", "id": "s1791"}
{"text": "1、本次随访需要行治疗性胃镜（明确有胃、食管黏膜病变需内镜下治疗者）；", "label": 5, "label_text": "Multiple", "id": "s1792"}
{"text": " 5、受试者知情，自愿签署知情同意书，并同意按照试验方案的要求参加所有的访视及检查、治疗。", "label": 5, "label_text": "Multiple", "id": "s1793"}
{"text": " （3）半年内有心肌梗塞、严重心律失常病史；", "label": 4, "label_text": "Disease", "id": "s1794"}
{"text": " 3. 症状未控制的脑转移的患者；", "label": 4, "label_text": "Disease", "id": "s1795"}
{"text": " 8. 对单克隆抗体任何成分过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1796"}
{"text": "1.年龄18-75岁", "label": 3, "label_text": "Age", "id": "s1797"}
{"text": " 5）BMI＞30；", "label": 9, "label_text": "Risk Assessment", "id": "s1798"}
{"text": " （2）符合中医粉刺肺经风热证诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s1799"}
{"text": " 3）符合DSM－Ⅳ精神分裂症诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s1800"}
{"text": " （7）近3个月内参加其它临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1801"}
{"text": " ⑤ 有出血倾向、活动性消化道溃疡、新近脑血管意外以及抗血小板制剂和抗凝剂治疗禁忌症者无法进行抗凝血治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s1802"}
{"text": "1) 年龄：18-80岁", "label": 3, "label_text": "Age", "id": "s1803"}
{"text": " 6.无物理治疗相关禁忌症；", "label": 4, "label_text": "Disease", "id": "s1804"}
{"text": " 2、具有基本的沟通理解能力 ；", "label": 25, "label_text": "Literacy", "id": "s1805"}
{"text": " （3）妊娠患者或患者正处于哺乳期；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1806"}
{"text": " 15.因其他疾病需要进行肛周手术的，或者有可能在治疗后26周内需要进行类似手术的；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1807"}
{"text": "1) 心脏病病史：充血性心力衰竭>NYHA 心功能分级 2 级；活动性冠心病 (参加研究前 6 个月心肌梗塞的患者可以进入本试验)；心律失常需要抗心律失常治疗（允许使用 beta 受体阻滞剂及地高辛）或者未控制的高血压", "label": 5, "label_text": "Multiple", "id": "s1808"}
{"text": " 2.18岁以上，或者14岁以上且体重>50Kg", "label": 5, "label_text": "Multiple", "id": "s1809"}
{"text": " 5）术前四项检查（HIV、乙型肝炎表面抗原、丙型肝炎、梅毒抗体）阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1810"}
{"text": "1. 颅内高压或意识不清；", "label": 1, "label_text": "Sign", "id": "s1811"}
{"text": " （5）患有帕金森症（病）严重程度足以增加跌倒的可能性或危及康复；", "label": 4, "label_text": "Disease", "id": "s1812"}
{"text": "1.符合ISSVA诊断标准的婴幼儿血管瘤患儿", "label": 11, "label_text": "Diagnostic", "id": "s1813"}
{"text": " (5)全身情况能够耐受大型手术。", "label": 7, "label_text": "Allergy Intolerance", "id": "s1814"}
{"text": " 3.其余非糖尿病眼病合并，干扰眼底检查观察结果患者（如青光眼、甲状腺眼病、非糖尿病出血性眼底病、葡萄膜炎、视网膜脱落、视神经疾病、眼屈光间质异常等）；", "label": 4, "label_text": "Disease", "id": "s1815"}
{"text": " 2）腹部手术后患者：包括胃、结直肠、胰腺、胆囊等开腹及腹腔镜手术后患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1816"}
{"text": " ③ ASA分级I~II级；", "label": 9, "label_text": "Risk Assessment", "id": "s1817"}
{"text": "（1）已知对透析器材料、血液灌流器有过敏反应、禁忌证或不能耐受者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1818"}
{"text": " ⑤长期使用激素史", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1819"}
{"text": " 7. 有严重心脑血管疾患、心律失常、充血性心力衰竭、肺病（FVC<50%预测, DLCO <50％预测;静息血氧饱和度<95％）、血液系统疾患、mikulicz病、结节病、糖尿病及移植排斥反应患者；", "label": 5, "label_text": "Multiple", "id": "s1820"}
{"text": " 4)既往有药物滥用病史或药物筛查试验阳性者；", "label": 5, "label_text": "Multiple", "id": "s1821"}
{"text": " 4.有癫痫病史或目前正在服用抗惊厥药物；", "label": 5, "label_text": "Multiple", "id": "s1822"}
{"text": " 5.东部肿瘤协作组(ECOG)PS 为 0 或 1", "label": 9, "label_text": "Risk Assessment", "id": "s1823"}
{"text": "(1)合并心脑血管、肝脏、造血系统等严重原发病的患者；", "label": 4, "label_text": "Disease", "id": "s1824"}
{"text": " 10)筛选前30天内参加了其他的药物或医疗器械临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1825"}
{"text": " 11)3个月内参加过其他药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1826"}
{"text": "（1）各种手术术后；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1827"}
{"text": " 5.依从性差，不愿加入该试验者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s1828"}
{"text": " 2） 性别不限，年龄18-50岁；", "label": 5, "label_text": "Multiple", "id": "s1829"}
{"text": " 5.肝功能正常：血清肌酐≤1.5xULN，且肌酐清除率≥60 ml/min。", "label": 5, "label_text": "Multiple", "id": "s1830"}
{"text": " 2.患有传染病、湿疹、皮炎或存在外伤、感染者。", "label": 4, "label_text": "Disease", "id": "s1831"}
{"text": " 9.不能、不愿意或者不同意遵守研究要求，包括生活方式调整、回访、剂量说明和受试者职责；", "label": 13, "label_text": "Consent", "id": "s1832"}
{"text": " 3、 年龄在 18- 65 岁；", "label": 3, "label_text": "Age", "id": "s1833"}
{"text": " ② 单孔胸腔镜下手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1834"}
{"text": "1）任何异常且有临床意义的医学检查发现", "label": 12, "label_text": "Laboratory Examinations", "id": "s1835"}
{"text": " 1)患先天性或获得性免疫缺陷病，或在rTV疫苗接种后1个月内的密切接触者中有以上患者；", "label": 4, "label_text": "Disease", "id": "s1836"}
{"text": " 7. 15 日内服用过单胺氧化酶抑制药物或抗抑郁药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1837"}
{"text": " 7、首次发病患者或者复发性中风患者在本次疾病发作前已经完全恢复患者，其mRS分为0-1分；", "label": 5, "label_text": "Multiple", "id": "s1838"}
{"text": " （2）有依托咪酯或者丙泊酚使用禁忌症；", "label": 4, "label_text": "Disease", "id": "s1839"}
{"text": " 5. 伴有慢性便秘或者慢性腹泻等胃肠道症状超过3个月。", "label": 28, "label_text": "Symptom", "id": "s1840"}
{"text": "1.年龄40-75岁", "label": 3, "label_text": "Age", "id": "s1841"}
{"text": "1. 初发（新诊断）CAEBV患者；", "label": 4, "label_text": "Disease", "id": "s1842"}
{"text": " 7.距上一次化疗、放疗（非靶病灶放疗除外）至少4周。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1843"}
{"text": " k） 正在参加其它临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s1844"}
{"text": " 6、主要脏器无严重器质性病变（由本病引起的肾功能不全除外），符合以下实验室检查指标的要求（在治疗前7 天之内进行）：", "label": 1, "label_text": "Sign", "id": "s1845"}
{"text": " (5)妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1846"}
{"text": "1.恶性血液病，异基因造血干细胞移植", "label": 5, "label_text": "Multiple", "id": "s1847"}
{"text": " 2) 未治愈的输卵管积水、子宫内膜异位症、宫腔粘连；", "label": 4, "label_text": "Disease", "id": "s1848"}
{"text": " ⑤四肢浅感觉、深感觉、肌力、肌张力正常，病理征阴性；", "label": 1, "label_text": "Sign", "id": "s1849"}
{"text": " 7.如患者术前曾行介入治疗，在入组前治疗需已停止4周以上。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1850"}
{"text": "① 合并预期寿命小于1年的终末期疾病；", "label": 5, "label_text": "Multiple", "id": "s1851"}
{"text": " ⑵愿意签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s1852"}
{"text": " 5.经过PG-SGA营养风险评估，PG-SGA≥2分；", "label": 9, "label_text": "Risk Assessment", "id": "s1853"}
{"text": " （5）合并有严重心血管病变的患者，如严重心律失常（房颤、病态窦房结综合征等）、心功能不全（NYHA分级≥III级）、不稳定型心绞痛、急性心肌梗死等；", "label": 5, "label_text": "Multiple", "id": "s1854"}
{"text": " ⑺ 无典型的间质性肺炎或肺纤维化；", "label": 4, "label_text": "Disease", "id": "s1855"}
{"text": " 4. 患者入组前 4 周内患有无法控制的感染疾病；", "label": 4, "label_text": "Disease", "id": "s1856"}
{"text": " 2) 本次发病后采用血管开通（如溶栓、动脉取栓、超早期血栓抽吸和支架成形术等）等治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1857"}
{"text": " 4.预计生存期≥12月；", "label": 23, "label_text": "Life Expectancy", "id": "s1858"}
{"text": " 2、患者为住院的符合CCMD-3精神分裂症诊断标准精神分裂症急性期者；", "label": 11, "label_text": "Diagnostic", "id": "s1859"}
{"text": " （3）以下肢腓肠肌、腘绳肌、内收肌群为靶肌；", "label": 5, "label_text": "Multiple", "id": "s1860"}
{"text": " d、患者愿意接受本课题规定的方法治疗。", "label": 13, "label_text": "Consent", "id": "s1861"}
{"text": " 8)膝下动脉病变为腘动脉病变直接延续；", "label": 4, "label_text": "Disease", "id": "s1862"}
{"text": " 8）既往有出凝血异常病史或凝血功能异常，如凝血酶原时间-国际标准化比值(PT-INR) 、活化部分凝血活酶时间 (APTT)值超出正常范围的20％；", "label": 5, "label_text": "Multiple", "id": "s1863"}
{"text": " 2)男性受试者体重应不低于50.0kg，女性受试者体重应大于45.0kg，体重指数（BMI）19.0-28.0kg/m2 [BMI=体重(kg)/身高(m)2]（含19.0和28.0 kg/m2）；", "label": 5, "label_text": "Multiple", "id": "s1864"}
{"text": " （2）出疹时间超过两周者；", "label": 4, "label_text": "Disease", "id": "s1865"}
{"text": " 8)术前7天内使用过溶栓药物（包括尿激酶、阿替普酶等）的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1866"}
{"text": " （11）AST和ALT≤2.5倍正常参考值上限，存在肝转移灶的受试者应≤5倍正常参考值上限", "label": 12, "label_text": "Laboratory Examinations", "id": "s1867"}
{"text": " 2)对于病变为结石的受试者，考虑到无需分次碎石，结石直径需小于等于2cm；", "label": 5, "label_text": "Multiple", "id": "s1868"}
{"text": " ⑨按照国际勃起功能国际问卷表（IIEF）和排尿功能量表评估排尿功能和性功能正常者", "label": 11, "label_text": "Diagnostic", "id": "s1869"}
{"text": " （4）有6个月及其以上的月经相关性无先兆偏头痛病史；", "label": 4, "label_text": "Disease", "id": "s1870"}
{"text": " 4. 患有高血压，且经降压药物治疗无法降至正常范围内者（收缩压＞140 mmHg，舒张压＞90 mmHg）；", "label": 5, "label_text": "Multiple", "id": "s1871"}
{"text": " ②年龄在18～45 岁之间的女性；", "label": 5, "label_text": "Multiple", "id": "s1872"}
{"text": " 8) 梅毒性耳聋病史", "label": 4, "label_text": "Disease", "id": "s1873"}
{"text": " (3) 重症急性胰腺炎（severe acute pancreatitis，SAP）患者，根据改良后亚特兰大急性胰腺炎分类标准，SAP的诊断标准如下(满足以下任何1条)：", "label": 11, "label_text": "Diagnostic", "id": "s1874"}
{"text": "1. 年龄≥60岁；", "label": 3, "label_text": "Age", "id": "s1875"}
{"text": " 3) 心脏神经综合症、β受体过敏综合症、扩张型心脏病等出现类似临床表现者。", "label": 4, "label_text": "Disease", "id": "s1876"}
{"text": " 4. 有过癫痫发作的病史。", "label": 4, "label_text": "Disease", "id": "s1877"}
{"text": " 8、选期女性病人血红蛋白< 11.5 g/dL 或男性病人血红蛋白<12.5 g/dL", "label": 12, "label_text": "Laboratory Examinations", "id": "s1878"}
{"text": " 3.急性感染者，及严重感染未控制或高热患者；", "label": 4, "label_text": "Disease", "id": "s1879"}
{"text": " 7.男或女性≥18周岁，且≤75周岁；", "label": 5, "label_text": "Multiple", "id": "s1880"}
{"text": " （3）规律腹膜透析治疗≥1个月；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1881"}
{"text": "1.进行至少3个月的血液透析或持续非卧床腹膜透析的慢性肾衰患者；", "label": 5, "label_text": "Multiple", "id": "s1882"}
{"text": " ④近期无迁出当地（1年内无拆迁计划）或长期（1年及以上的）外出计划；", "label": 40, "label_text": "Address", "id": "s1883"}
{"text": " （4） 具有生育能力的女性受试者在试验期间（共32周）同意采取双重医学认可的可靠避孕措施，即包括一种药物和一种非药物的避孕措施；男性受试者的配偶若具有生育能力，每次性生活时同意采用乳胶避孕套进行避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1884"}
{"text": " 11.正在参加其他临床试验的患者.", "label": 15, "label_text": "Enrollment in other studies", "id": "s1885"}
{"text": " ⑤ 心、脑、肾功能衰竭患者", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1886"}
{"text": " 3)签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s1887"}
{"text": "1. 转入时已确定存在 CRE 感染;", "label": 4, "label_text": "Disease", "id": "s1888"}
{"text": " 6、体力状况及脏器功能允许接受较大的腹部手术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1889"}
{"text": " 9、体循环血压较低的患者(血压<90／50mmHg)或未控制的高血压患者(血压>170／110mmHg)；", "label": 5, "label_text": "Multiple", "id": "s1890"}
{"text": " 4)拒绝签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s1891"}
{"text": "1.重症流行性感冒以及具有并发症的流感患者（有流行性感冒并发症者，如继发细菌性肺炎、其它病原菌所致肺炎及其它病毒性肺炎等）；", "label": 4, "label_text": "Disease", "id": "s1892"}
{"text": " （4）临床和/或病理证明肿瘤已侵袭到其他器官或组织；", "label": 11, "label_text": "Diagnostic", "id": "s1893"}
{"text": " （4）患者知晓并签署同意书，同意参与该项研究。", "label": 13, "label_text": "Consent", "id": "s1894"}
{"text": " （5）酗酒（饮白酒150g/d以上，或啤酒500ml/d以上）", "label": 2, "label_text": "Addictive Behavior", "id": "s1895"}
{"text": " 3）有严重心、肺、肝、肾疾患而不能耐受腔镜手术者；", "label": 5, "label_text": "Multiple", "id": "s1896"}
{"text": " ⑥对毒素制品中任何成分过敏者或过敏体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1897"}
{"text": " 5.重大手术史患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1898"}
{"text": " [2]青光眼病情：早、中期视野损害（MD-0.01 to -6.00或MD-6.01 to-12.00）", "label": 4, "label_text": "Disease", "id": "s1899"}
{"text": " （5）一个或多个认知领域损伤的客观证据，通常包括记忆（如正规的或床边的测试以确定多个领域的认知功能水平）；", "label": 11, "label_text": "Diagnostic", "id": "s1900"}
{"text": "1) 既往任何原因接受细胞毒化疗内分泌治疗生物治疗或放射治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s1901"}
{"text": " 4、HAMA焦虑量表得分≥14分，其中焦虑心境（第1项）得分≥2分；", "label": 9, "label_text": "Risk Assessment", "id": "s1902"}
{"text": " 4)任何具有明显临床意义的实验室检查结果异常，如肌酐值≥2倍正常值高限或ALT或AST≥2.5倍正常值高限（肝转移患者可放宽到≥5倍正常值高限）或肝功能Child C级别；", "label": 5, "label_text": "Multiple", "id": "s1903"}
{"text": " 4.在随访期有高死亡风险或预计不能完成研究的", "label": 5, "label_text": "Multiple", "id": "s1904"}
{"text": "1.年龄18-65岁的女性，；", "label": 5, "label_text": "Multiple", "id": "s1905"}
{"text": " ②合并有肝、心、肾、造血系统、全身感染或传染性疾病者；", "label": 4, "label_text": "Disease", "id": "s1906"}
{"text": " ③双侧或多灶性起源的癫痫；", "label": 4, "label_text": "Disease", "id": "s1907"}
{"text": "1 有任何临床严重疾病史或有循环系统、泌尿系统、内分泌系统、神经系统疾病或血液学、免疫学、精神病学疾病、肿瘤及代谢异常等病史者；", "label": 4, "label_text": "Disease", "id": "s1908"}
{"text": " （5）术前评估既可开腹也可腔镜完成手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s1909"}
{"text": " (3)符合中医肝脾不和证辨证标准", "label": 11, "label_text": "Diagnostic", "id": "s1910"}
{"text": " 9.酗酒或药物滥用者；", "label": 2, "label_text": "Addictive Behavior", "id": "s1911"}
{"text": " 7). 预计生存期≥4个月；", "label": 23, "label_text": "Life Expectancy", "id": "s1912"}
{"text": " 治疗组：", "label": 0, "label_text": "Therapy or Surgery", "id": "s1913"}
{"text": " 6) 妊娠或者哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1914"}
{"text": "1. 急性梗阻性化脓性胆管炎；", "label": 4, "label_text": "Disease", "id": "s1915"}
{"text": " f. 有医学教育背景的患者。", "label": 41, "label_text": "Education", "id": "s1916"}
{"text": " （3）随访时间不足6月。", "label": 8, "label_text": "Compliance with Protocol", "id": "s1917"}
{"text": " 4. 急诊手术者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1918"}
{"text": " 6，正常的肝功能：谷丙转氨酶(alanine aminotransferase, ALT)、谷草转氨酶(aspartate aminotransferase, AST) < 1.5倍的正常值上限(upper limit of normal, ULN)，同时碱性磷酸酶(alkaline phosphatase, ALP) < 2.5×ULN以及胆红素 < ULN。", "label": 5, "label_text": "Multiple", "id": "s1919"}
{"text": " 5.内分泌紊乱、神经衰弱、神经官能症及高血压等患者。", "label": 4, "label_text": "Disease", "id": "s1920"}
{"text": " 11.对艾灸烟雾过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1921"}
{"text": " 子宫内膜异位症或子宫腺肌症", "label": 4, "label_text": "Disease", "id": "s1922"}
{"text": "1.脑器质性疾病或其它有临床意义的并发躯体疾病", "label": 4, "label_text": "Disease", "id": "s1923"}
{"text": "1.拟行择期电休克治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s1924"}
{"text": " 2.其它可能导致无法完成试验的严重疾病；", "label": 4, "label_text": "Disease", "id": "s1925"}
{"text": "1. 术前接受溶栓治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1926"}
{"text": "1.肺鳞癌（包括含有鳞癌成分的肺癌）；大细胞肺癌（包括大细胞癌与非大细胞混合的肺癌）；小细胞肺癌（包括小细胞癌与非小细胞混合的肺癌）；", "label": 4, "label_text": "Disease", "id": "s1927"}
{"text": " 8)同时参加其它临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s1928"}
{"text": " 9.正在接受抗凝治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s1929"}
{"text": " （6）已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s1930"}
{"text": " 2.继发于全身疾病的肝损伤，如各种自身免疫性疾病累及肝脏。", "label": 4, "label_text": "Disease", "id": "s1931"}
{"text": " ②临床确诊淋巴瘤，经血液专科医师评估后有化疗指征，拟接受包括蒽环类抗肿瘤药物在内的化疗方案进行化疗者。", "label": 5, "label_text": "Multiple", "id": "s1932"}
{"text": " （6)既往未接受激素治疗或接受过激素治疗（强的松≤0.5mg/kg/day）、过去3个月内未使用免疫抑制剂或生物制剂者；", "label": 5, "label_text": "Multiple", "id": "s1933"}
{"text": " (4)入组前病程中未使用抗病毒药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1934"}
{"text": " 3、热力烧伤患者。", "label": 4, "label_text": "Disease", "id": "s1935"}
{"text": " 14）研究者认为不宜参与本试验的其它情况者。", "label": 21, "label_text": "Researcher Decision", "id": "s1936"}
{"text": " ③勃起硬度分级（EHS）三级及以下", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s1937"}
{"text": " g.愿意遵从研究者的指导按时参加访视并使用研究产品；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1938"}
{"text": " 4.自愿接受本试验并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s1939"}
{"text": "（1）病理确诊的非小细胞肺癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s1940"}
{"text": " 4.血象、心、肺、肝、肾功能明显异常，代偿功能不足，或存在严重的全身系统疾病；", "label": 5, "label_text": "Multiple", "id": "s1941"}
{"text": " （5）无法保证完成术后规律随访及膀胱镜检。", "label": 8, "label_text": "Compliance with Protocol", "id": "s1942"}
{"text": " 4、服用非甾体抗炎药后出现支气管痉挛、鼻炎、荨麻疹反应的患者；", "label": 5, "label_text": "Multiple", "id": "s1943"}
{"text": "1.符合糖尿病诊断标准的患者。", "label": 11, "label_text": "Diagnostic", "id": "s1944"}
{"text": " 8. 长期服用咖啡。", "label": 18, "label_text": "Diet", "id": "s1945"}
{"text": " （2）预计重症医学科住院时间2周以上；", "label": 26, "label_text": "Encounter", "id": "s1946"}
{"text": " 4. 普通人群：无鼻炎、哮喘症状人群，比如体检人群（可部分单位选做）", "label": 5, "label_text": "Multiple", "id": "s1947"}
{"text": " 5. 心功能正常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1948"}
{"text": " 1.将进入或经过黄热病流行地区人员；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s1949"}
{"text": "①局部病灶不适合SRS的情况", "label": 4, "label_text": "Disease", "id": "s1950"}
{"text": " 入组前3 个月内服用了唑烷二酮类药物 (TZDs)、达英35或其他激素类药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1951"}
{"text": " 3. 汉族；", "label": 31, "label_text": "Ethnicity", "id": "s1952"}
{"text": " 6.其他终末期疾病；", "label": 4, "label_text": "Disease", "id": "s1953"}
{"text": " 4. 健康情况稳定；且有营养不良或营养不良风险（MNA-SF≤11分）。?", "label": 5, "label_text": "Multiple", "id": "s1954"}
{"text": " 4.研究者认为可以获益。", "label": 21, "label_text": "Researcher Decision", "id": "s1955"}
{"text": " 10. 妊娠", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1956"}
{"text": " 9.既往配戴过角膜塑形用硬性透气性接触镜的受试者，及既往30天内使用过阿托品或哌仑西平的受试者；", "label": 5, "label_text": "Multiple", "id": "s1957"}
{"text": " ②中医辨证属气滞血瘀证或寒凝血瘀证；", "label": 11, "label_text": "Diagnostic", "id": "s1958"}
{"text": " ④预计生存期大于6个月。", "label": 23, "label_text": "Life Expectancy", "id": "s1959"}
{"text": " （8）定期服用影响血脂药物者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1960"}
{"text": " 3. 新鲜肿瘤组织≥6g;", "label": 24, "label_text": "Neoplasm Status", "id": "s1961"}
{"text": " 10.患有IBD、库兴综合征、垂体功能异常；", "label": 4, "label_text": "Disease", "id": "s1962"}
{"text": " （3）多普勒超声评估：左室射血分数（LVEF）≥正常值低限（50%）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1963"}
{"text": " 3)DAS28-ESR大于或等于3.2", "label": 12, "label_text": "Laboratory Examinations", "id": "s1964"}
{"text": " 10．家属或患者拒绝使用替罗非班者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1965"}
{"text": " (1)择期全麻腹部（胃、肠、肾、肝脏手术包括腹腔镜下及腹腔镜辅助下的胃肠手术）手术患者，手术时间1～4 h，术后须拔除气管内导管", "label": 0, "label_text": "Therapy or Surgery", "id": "s1966"}
{"text": " 3.有精神疾病等、预期会导致依从性不良的患者", "label": 5, "label_text": "Multiple", "id": "s1967"}
{"text": " 2.出凝血检查异常有临床意义；", "label": 12, "label_text": "Laboratory Examinations", "id": "s1968"}
{"text": "（1）认知能力差或不能坚持随访的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s1969"}
{"text": " 2.根据研究者判断，患者有自杀或者伤害他人的危险，或者 HAMD-17 项条目 3评分≥3，或者在过去半年内有自杀未遂者；", "label": 5, "label_text": "Multiple", "id": "s1970"}
{"text": " (9)筛选期头颅MRI平扫：显示AD的可能性最大(内侧颞叶萎缩视觉评定量表MTA分级为2级或更高)；如患者可提供在筛选前3个月内符合方案要求的头颅MRI片，可作为入组依据，不必重复拍摄；若研究者无法判断受试者病情是否发生变化，可再增加入组前头颅MRI平扫检查；", "label": 5, "label_text": "Multiple", "id": "s1971"}
{"text": " （2）ECOG评分0-2分（附件1），估计生存期≥6个月；", "label": 5, "label_text": "Multiple", "id": "s1972"}
{"text": " ②合并有先天性子宫发育不良、卵巢发育不全、子宫内膜结核、盆腔器官组织恶性肿瘤、严重皮肤病以及精神病患者；", "label": 4, "label_text": "Disease", "id": "s1973"}
{"text": "1) 术眼合并有其他眼部疾病有植入人工晶状体禁忌症者，如小眼球或大眼球，恶性青光眼，较重的角膜营养不良，不可控制的眼压过高，明显的黄斑/色素上皮细胞病变，糖尿病视网膜病变，严重的视神经萎缩，大量的玻璃体流失，慢性或重症葡萄膜炎，严重的前房过浅，脉络膜出血，后囊破裂或睫状小带分离（不能固定人工晶状体），色觉缺陷，以及伴发的其他严重眼部疾病；", "label": 5, "label_text": "Multiple", "id": "s1974"}
{"text": " (14) 入组前8周内化疗史，或者预计在强脉冲光治疗后8周内进行化疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s1975"}
{"text": " 2椎管内麻醉的禁忌症", "label": 4, "label_text": "Disease", "id": "s1976"}
{"text": " 6）有急性感染体征的患者。", "label": 4, "label_text": "Disease", "id": "s1977"}
{"text": " ②严重脊柱创伤史。", "label": 4, "label_text": "Disease", "id": "s1978"}
{"text": " （3）具有生育能力的受试者须接受有效的医学避孕措施", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s1979"}
{"text": "（1）继发性膝关节骨关节炎；", "label": 4, "label_text": "Disease", "id": "s1980"}
{"text": " 6、影响呼吸运动功能的神经肌肉疾病；", "label": 4, "label_text": "Disease", "id": "s1981"}
{"text": " 11 对研究用药过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s1982"}
{"text": " 2，年龄18-60岁；", "label": 3, "label_text": "Age", "id": "s1983"}
{"text": " 4.具有术前1个月内未行任何阴道炎相关治疗的阴道微生态结果集HPV随访资料；", "label": 22, "label_text": "Data Accessible", "id": "s1984"}
{"text": " 6)主要器官功能正常，符合如下标准", "label": 6, "label_text": "Organ or Tissue Status", "id": "s1985"}
{"text": " （2）根据EASL标准确诊的肝细胞癌(单病灶≤8cm或最多3个病灶≤3cm)；", "label": 11, "label_text": "Diagnostic", "id": "s1986"}
{"text": " 3.眼压失控者。", "label": 1, "label_text": "Sign", "id": "s1987"}
{"text": "（1）年龄18～70岁；性别不限。", "label": 5, "label_text": "Multiple", "id": "s1988"}
{"text": " 9.血糖控制不佳，治疗后空腹血浆葡萄糖(FPG)水平>7.0mmol/l(126mg/dl)；", "label": 5, "label_text": "Multiple", "id": "s1989"}
{"text": " 2.年龄≥70岁或≥60岁伴ECOG PS≥2分", "label": 5, "label_text": "Multiple", "id": "s1990"}
{"text": " 2)焦虑或抑郁患者；", "label": 28, "label_text": "Symptom", "id": "s1991"}
{"text": " 3)影像学资料（包括X线、MRI、CT和骨扫描）完整；", "label": 22, "label_text": "Data Accessible", "id": "s1992"}
{"text": " (3)充分理解临床试验宗旨，基于本人意愿签署参加临床试验知情同意书者", "label": 13, "label_text": "Consent", "id": "s1993"}
{"text": " 年龄18-70岁，能理解各项量表及测试内容；", "label": 5, "label_text": "Multiple", "id": "s1994"}
{"text": " 6)筛选前1周内的服用营养补充剂的习惯有改变，或打算在整个研究期间改变目前服用习惯。营养补充剂包括任何维生素、矿物质和中草药补品。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s1995"}
{"text": " 2.在我院神经康复科住院的患者；", "label": 26, "label_text": "Encounter", "id": "s1996"}
{"text": " 3.无法吞咽或既往接受亚硝脲类烷化剂剧烈呕吐者；", "label": 5, "label_text": "Multiple", "id": "s1997"}
{"text": " 3、年龄30～80岁，男女不限", "label": 5, "label_text": "Multiple", "id": "s1998"}
{"text": " （7）父母不同意签署课题研究知情同意书的新生儿；", "label": 13, "label_text": "Consent", "id": "s1999"}
{"text": " 9) 类固醇激素禁忌症，如青光眼", "label": 4, "label_text": "Disease", "id": "s2000"}
{"text": " （2）未使用过抗糖尿病药", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2001"}
{"text": " 6.实验室检查有显著异常，研究者认为不适合参加和完成研究的：", "label": 21, "label_text": "Researcher Decision", "id": "s2002"}
{"text": " ③从未出现过重性抑郁发作，且不符合恶劣心境的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2003"}
{"text": " （2）未获得知情同意者；", "label": 13, "label_text": "Consent", "id": "s2004"}
{"text": " 5）任何含磁性或者金属的物质（包括起搏器、手术后的动脉夹）", "label": 34, "label_text": "Device", "id": "s2005"}
{"text": "1.符合急性冠脉综合征(包括不稳定型心绞痛和非ST抬高型心肌梗死)诊断；", "label": 11, "label_text": "Diagnostic", "id": "s2006"}
{"text": " 12) 受试者未采取有效的避孕措施或半年内有生育计划，或女性受试者妊娠试验阳性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2007"}
{"text": " 6.有异烟肼和利福喷丁用药过敏史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2008"}
{"text": "1）年龄50-70周岁；", "label": 3, "label_text": "Age", "id": "s2009"}
{"text": "1) 术前有明确的咳嗽病史；", "label": 4, "label_text": "Disease", "id": "s2010"}
{"text": "1.间质性肺炎或者肺纤维化；", "label": 4, "label_text": "Disease", "id": "s2011"}
{"text": " （5）低蛋白血症TP <45g/L", "label": 5, "label_text": "Multiple", "id": "s2012"}
{"text": " （8）正参加其它临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2013"}
{"text": "1.唇腭裂", "label": 4, "label_text": "Disease", "id": "s2014"}
{"text": " 2.经影像学、骨髓穿刺或活检证实发生骨转移的淋巴瘤患者；", "label": 11, "label_text": "Diagnostic", "id": "s2015"}
{"text": " 6.不能自我评估者；", "label": 17, "label_text": "Capacity", "id": "s2016"}
{"text": " ②病程>1个月；", "label": 4, "label_text": "Disease", "id": "s2017"}
{"text": " （4）支气管哮喘急性发作；", "label": 4, "label_text": "Disease", "id": "s2018"}
{"text": " 3. 孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2019"}
{"text": " 4、伴有至少一个心血管危险因素：腹型肥胖（腰围男性≥85cm,女性≥80cm）或超重（体重指数≥27kg/m2）、空腹血糖受损或糖尿病、吸烟、缺乏体力活动、血脂异常、早发心血管病或中风病家族史（一级直系亲属的男性发病年龄<55岁，女性发病年龄<65岁）。", "label": 5, "label_text": "Multiple", "id": "s2020"}
{"text": "1.3个月内曾使用激素类避孕药（包括口服避孕药，皮下植入避孕药，孕激素宫内释放装置等。", "label": 5, "label_text": "Multiple", "id": "s2021"}
{"text": "A.综合医院就诊的门诊、住院人群；", "label": 26, "label_text": "Encounter", "id": "s2022"}
{"text": " (12)迟滞：反应慢(别人说好几句话，患者才能应答一句)，思维转不动、记忆力下降、容易忘事。", "label": 28, "label_text": "Symptom", "id": "s2023"}
{"text": " 14、血浆电解质水平（血钾）高于正常范围的患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2024"}
{"text": " 3.有上消化道出血史或者胃镜证实有出血倾向的患者", "label": 1, "label_text": "Sign", "id": "s2025"}
{"text": " 3. 术前肝肾功能异常或有其他系统合并症的患者.", "label": 5, "label_text": "Multiple", "id": "s2026"}
{"text": " 6.患者及家属不愿接受治疗或不积极配合者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s2027"}
{"text": " 2.有症状的脑转移、癌性脑膜炎（入组前21天已完成治疗且症状稳定的脑转移患者可以入组，但需经颅脑MRI、CT或静脉造影评价确认为无脑出血症状）；", "label": 5, "label_text": "Multiple", "id": "s2028"}
{"text": " 2）手术时间≥ 90min、术中出血≥200ml、中转开腹或者术后留置尿管的患者；", "label": 5, "label_text": "Multiple", "id": "s2029"}
{"text": " 5)未用过糖皮质激素", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2030"}
{"text": " （2）诊断不符合1995年全国第四届脑血管病学术会议通过的各类脑血管病诊断要点", "label": 11, "label_text": "Diagnostic", "id": "s2031"}
{"text": " 6、签署自愿参加临床试验知情同意书的患者", "label": 13, "label_text": "Consent", "id": "s2032"}
{"text": " B. 年龄18-65岁。", "label": 3, "label_text": "Age", "id": "s2033"}
{"text": " ⑤严重肝肾功能障碍；合并心脏病如充血性心力衰竭、恶性心律失常等；", "label": 5, "label_text": "Multiple", "id": "s2034"}
{"text": " 19.活动性病毒、真菌或细菌感染；", "label": 4, "label_text": "Disease", "id": "s2035"}
{"text": "1.曾经因子宫颈癌前病变而接受治疗者。", "label": 5, "label_text": "Multiple", "id": "s2036"}
{"text": " ③药物依赖；", "label": 2, "label_text": "Addictive Behavior", "id": "s2037"}
{"text": "1.难治/复发白血病首次异基因造血干细胞移植后行预防性供者淋巴细胞输注（DLI）后白血病复发", "label": 5, "label_text": "Multiple", "id": "s2038"}
{"text": " （3）中医辨为气虚、肾气虚、肾阳虚的患者；", "label": 11, "label_text": "Diagnostic", "id": "s2039"}
{"text": " 2.头部外伤史，意识丧失超过1小时；或明显智力低下", "label": 5, "label_text": "Multiple", "id": "s2040"}
{"text": " （2）影像学表现腰椎管狭窄合并包容性腰椎间盘突出，且与症状体征相一致；", "label": 11, "label_text": "Diagnostic", "id": "s2041"}
{"text": "① 与其它精神疾病共病；", "label": 4, "label_text": "Disease", "id": "s2042"}
{"text": " ②血液透析。", "label": 0, "label_text": "Therapy or Surgery", "id": "s2043"}
{"text": " 6)无精神疾患，意识清醒，语言表达能力正常，能理解VAS评分，并配合治疗与评估。", "label": 5, "label_text": "Multiple", "id": "s2044"}
{"text": "1）年龄18岁以上，自愿参加本研究的病人；", "label": 5, "label_text": "Multiple", "id": "s2045"}
{"text": " 3)脑出血开颅手术患者，蛛网膜下腔出血患者。", "label": 5, "label_text": "Multiple", "id": "s2046"}
{"text": " 5.有严重的肾脏、心血管、肺部、神经系统、自身免疫性以及骨骼疾病；", "label": 4, "label_text": "Disease", "id": "s2047"}
{"text": " （14）对本次研究药物过敏或严重过敏性体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2048"}
{"text": " 6.签署知情同意书，自愿参加本研究者。", "label": 13, "label_text": "Consent", "id": "s2049"}
{"text": "1 有严重感染未控制", "label": 4, "label_text": "Disease", "id": "s2050"}
{"text": " 9.预计生存3个月以上。", "label": 23, "label_text": "Life Expectancy", "id": "s2051"}
{"text": " （2）除认知功能损害外，没有局灶性神经体征；", "label": 5, "label_text": "Multiple", "id": "s2052"}
{"text": " 2)结节最大直径＞2cm", "label": 24, "label_text": "Neoplasm Status", "id": "s2053"}
{"text": " 7、特殊部位肌瘤：粘膜下肌瘤，带蒂浆膜下肌瘤，宫颈肌瘤等；", "label": 4, "label_text": "Disease", "id": "s2054"}
{"text": " （4）中重度活动期溃疡性结肠炎患者（即Mayo评分≥6分；Mayo内镜评分≥2分）14例，缓解期溃疡性结肠炎患者6例：", "label": 5, "label_text": "Multiple", "id": "s2055"}
{"text": " ⑺经基础降糖，血糖控制达标者【糖化血红蛋白（HbAIc）≤7.5%】；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2056"}
{"text": " 6.家属拒绝相关治疗者。", "label": 13, "label_text": "Consent", "id": "s2057"}
{"text": " 4）能够与研究者良好交流，并遵守整个试验要求；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2058"}
{"text": " （4）合并心、肺、肾等重要脏器严重器质性病变，术前评估手术风险高，风险评分≥3分者；", "label": 5, "label_text": "Multiple", "id": "s2059"}
{"text": " 7.过敏性体质，有胶原过敏或其他严重过敏反应既往史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2060"}
{"text": " 4、图像中有测量标记、箭头或穿刺针；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s2061"}
{"text": " （3）妊娠期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2062"}
{"text": " 4）筛选前 30 天内有活动性上消化道溃疡的证据，或筛选前 1 年内有上消化道出血、或有胃十二指肠穿孔、梗阻病史的患者；", "label": 5, "label_text": "Multiple", "id": "s2063"}
{"text": " （5）根据“中风病中医证候诊断量表”诊断为具备气虚证和血瘀证的患者。", "label": 11, "label_text": "Diagnostic", "id": "s2064"}
{"text": " 12. 正在参加另外一项临床研究者.", "label": 15, "label_text": "Enrollment in other studies", "id": "s2065"}
{"text": " （5）有严重肾功能障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2066"}
{"text": " 5）筛选前30天内，未使用抗生素。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2067"}
{"text": " 4. 世界卫生组织（WHO）AML分类属不另做分类的AML的亚类中急性全髓增殖症伴骨髓纤维化及髓系肉瘤患者。", "label": 4, "label_text": "Disease", "id": "s2068"}
{"text": "   5.有献血反应史及曾发生过迟发性昏厥患者。", "label": 5, "label_text": "Multiple", "id": "s2069"}
{"text": " 患者一般状况可，生存预期在3个月以上者。", "label": 23, "label_text": "Life Expectancy", "id": "s2070"}
{"text": " ②处于COPD稳定期；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2071"}
{"text": "a) 年龄满 5 周岁，未满 18 周岁；", "label": 3, "label_text": "Age", "id": "s2072"}
{"text": " 12.没有采取有效的避孕措施且妊娠试验阳性记录的育龄期女性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2073"}
{"text": " 2.其他病因（包括自身免疫性、药物性、酒精性、中毒性、寄生虫性）导致的慢性重型肝炎；", "label": 4, "label_text": "Disease", "id": "s2074"}
{"text": " 2、年龄 18-90 岁；", "label": 3, "label_text": "Age", "id": "s2075"}
{"text": " 2)明确诊断或者临床怀疑梗阻性肾病引起的急性肾损伤患者", "label": 11, "label_text": "Diagnostic", "id": "s2076"}
{"text": " 3.患者月经规律，具体定义为周期长度 ≥21天并 ≤35天", "label": 5, "label_text": "Multiple", "id": "s2077"}
{"text": " 2.妊娠或准备妊娠、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2078"}
{"text": " ⑥　核磁或者CT上显示的重度椎管狭窄表现并有典型临床症状和体征者；", "label": 5, "label_text": "Multiple", "id": "s2079"}
{"text": " 9) 受试者日记，每日“关''期总计时间大于等于4小时。", "label": 5, "label_text": "Multiple", "id": "s2080"}
{"text": " 3.合并颅内动静脉畸形的患者", "label": 4, "label_text": "Disease", "id": "s2081"}
{"text": " 从已调查过的养老机构转入且已参与过本研究的人群", "label": 26, "label_text": "Encounter", "id": "s2082"}
{"text": " Ⅲ 多次复发；", "label": 4, "label_text": "Disease", "id": "s2083"}
{"text": " （2）精神或躯体上的残疾患者。", "label": 33, "label_text": "Disabilities", "id": "s2084"}
{"text": "         既往有吸毒、酒精或药物滥用病史；", "label": 2, "label_text": "Addictive Behavior", "id": "s2085"}
{"text": "1、经体表心电图或心内电生理检查证实为右室流出道室早，且总数占全部心搏数 10%以上者；", "label": 11, "label_text": "Diagnostic", "id": "s2086"}
{"text": "(1)因精神、语言等因素而影响资料收集者。", "label": 22, "label_text": "Data Accessible", "id": "s2087"}
{"text": " ⑧近3个月内参加其他药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2088"}
{"text": " （3）并发严重心肺功能不全者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2089"}
{"text": " 对照组排除标准：任何原因引起的急、慢性心力衰竭、急性心肌梗死、不稳定性心绞痛、癌症、感染性疾病及其他严重影响寿命的疾病。", "label": 4, "label_text": "Disease", "id": "s2090"}
{"text": " 4、需接受急诊手术的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2091"}
{"text": " 2) 年满18周岁的患者", "label": 3, "label_text": "Age", "id": "s2092"}
{"text": " 2）临床Ⅰ～Ⅲ期乳腺癌患者， IHC法检测：ER（-）、PR（-）、HER-2/neu（-）；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2093"}
{"text": " （3）合并有其他影响肢体活动功能的疾病者，治疗前合并有跛行、骨关节炎、类风湿关节炎、痛风性关节炎等引起的肢体活动功能障碍可能影响神经功能检查者；", "label": 4, "label_text": "Disease", "id": "s2094"}
{"text": " ⑧无活动性炎症和眼表疾病，无严重的眼附属器病变及眼部器质性病变；", "label": 4, "label_text": "Disease", "id": "s2095"}
{"text": " 8. 实验室检查结果符合以下条件：WBC≥4×10^9/L；Hb≥90 g/L；plt≥100×10^9/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2096"}
{"text": " 4)任何患有其他疾病、神经或代谢障碍，体格检查或实验室检查结果的证据合理怀疑有患病或存在使用相关药物的反指证或使受试者处于治疗相关并发症高风险中的可能；", "label": 4, "label_text": "Disease", "id": "s2097"}
{"text": " 3)受试者近1个月内参加过其它临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2098"}
{"text": "1.自愿受试并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2099"}
{"text": " 12. 研究者认为不适宜受试的其他患者。", "label": 21, "label_text": "Researcher Decision", "id": "s2100"}
{"text": " 3. DCD供肾", "label": 0, "label_text": "Therapy or Surgery", "id": "s2101"}
{"text": " 3.有长期服用精神类药物史的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2102"}
{"text": " ?患者或其委托代理人知情同意。", "label": 13, "label_text": "Consent", "id": "s2103"}
{"text": " 6．孕妇和哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2104"}
{"text": " ③同时服用5种或5种以上药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2105"}
{"text": " 10. 根据ACC/AHA/HRS 永久起搏器植入指南，患者是IIb或III类适应征；", "label": 11, "label_text": "Diagnostic", "id": "s2106"}
{"text": " 7.具有 AASLD肝移植指南规定的肝移植禁忌症（MELD Score < 15除外）", "label": 4, "label_text": "Disease", "id": "s2107"}
{"text": " 9. 出血及血栓性疾病；", "label": 5, "label_text": "Multiple", "id": "s2108"}
{"text": " （2）严重心、肝、肾功能不全者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2109"}
{"text": " 9.对免疫治疗及相关药物过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s2110"}
{"text": " 3.符合西医复发性尿路感染诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s2111"}
{"text": " 9其它不可控的可能会影响研究的疾病。", "label": 4, "label_text": "Disease", "id": "s2112"}
{"text": " （2）不能完成术前神经精神测验；", "label": 17, "label_text": "Capacity", "id": "s2113"}
{"text": "    ②  高危前列腺癌患者（T3a, N0, M0），同时预期寿命大于10年;", "label": 5, "label_text": "Multiple", "id": "s2114"}
{"text": " ⑤无严重心肝肾功能异常。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2115"}
{"text": " ③PSA＞10μｇ/Ｌ；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2116"}
{"text": " (2)18-75岁，男女均可；", "label": 5, "label_text": "Multiple", "id": "s2117"}
{"text": " 7)ECOG体力状况评分0-2", "label": 9, "label_text": "Risk Assessment", "id": "s2118"}
{"text": " ③ 进入研究时患者空腹血糖≤8mmol/L，餐后2h血糖≤11mmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2119"}
{"text": " 6.经研究者判断，受试者愿意并能够遵守所有的试验要求.", "label": 21, "label_text": "Researcher Decision", "id": "s2120"}
{"text": " 4. 胰岛仍有一定的胰岛素分泌功能，空腹血清C肽>正常值下限的1/2；", "label": 5, "label_text": "Multiple", "id": "s2121"}
{"text": " （4）合并心功能不全（纽约心脏协会功能分类[附一]III级以上）、不稳定心绞痛、心肌梗死、心电图（ECG）示左室肥厚、血管栓塞性疾病患者；", "label": 5, "label_text": "Multiple", "id": "s2122"}
{"text": " 2)伴有认知损害，定义：MMSE评分文盲≦17分，小学≦20分，中学以上≦24分，或MoCA评分<26分", "label": 9, "label_text": "Risk Assessment", "id": "s2123"}
{"text": " 4.签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2124"}
{"text": "  ⑺反复心力衰竭患者，动静脉瘘可能加重或诱发心力衰竭的病例。", "label": 4, "label_text": "Disease", "id": "s2125"}
{"text": "1、已有慢性疾病", "label": 4, "label_text": "Disease", "id": "s2126"}
{"text": "1. 慢性诱导性荨麻疹，如：人工荨麻疹，冷接触性荨麻疹，延迟压力性荨麻疹，热接触性荨麻疹，日光性荨麻疹，振动性荨麻疹或血管性水肿，胆碱能性荨麻疹，水源性荨麻疹，接触性荨麻疹，运动诱导性荨麻疹等有明确诱因者；", "label": 4, "label_text": "Disease", "id": "s2127"}
{"text": " 8.明显肝肾功能损坏（和/或 ALT、AST 水平高于正常值上限1倍，CCr<50%）；", "label": 5, "label_text": "Multiple", "id": "s2128"}
{"text": " 1.患者主要诊断为肿瘤、自身免疫性疾病等非感染性疾病；", "label": 4, "label_text": "Disease", "id": "s2129"}
{"text": " 8. 精神疾病及回忆障碍者；不能正确回答问题者；严重疾病及缺乏行为能力者等。", "label": 5, "label_text": "Multiple", "id": "s2130"}
{"text": " 3.存在脑功能紊乱的临床症状或严重的精神性疾病不能理解或遵从研究方案", "label": 5, "label_text": "Multiple", "id": "s2131"}
{"text": " 5.患者不配合或精神异常；", "label": 5, "label_text": "Multiple", "id": "s2132"}
{"text": " 15)病毒性肝炎（包括乙肝和丙肝）、艾滋病抗体、梅毒螺旋体抗体筛选阳性；", "label": 4, "label_text": "Disease", "id": "s2133"}
{"text": " 7）身体状况评分0-2级（ECOG评分）", "label": 9, "label_text": "Risk Assessment", "id": "s2134"}
{"text": " 5.同时参与另一项试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s2135"}
{"text": " （7） 已知或疑似依从性差不能完成试验者，如酗酒、药物依赖或精神疾病等 ；", "label": 5, "label_text": "Multiple", "id": "s2136"}
{"text": " 3.年龄为18-65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s2137"}
{"text": " 5)体检不符合受试者健康标准者：清醒状态脉搏<50次/分或者≥100次/分，或坐位收缩压<90mmHg或≥140mmHg、舒张压<60mmHg或≥90mmHg，或腋温>37.4℃；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2138"}
{"text": "1)试验前3个月内平均每日吸烟量多于5支者；", "label": 36, "label_text": "Smoking Status", "id": "s2139"}
{"text": " （8）蚕豆病患者；", "label": 4, "label_text": "Disease", "id": "s2140"}
{"text": " （4）伴或不伴不孕史，和（或）伴或不伴潮热出汗、情绪障碍、失眠、记忆力减退、生殖泌尿系萎缩等围绝经期症状；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2141"}
{"text": " 6.同步使用爱必妥等靶向药物者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2142"}
{"text": " 3、麻醉药物过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2143"}
{"text": " （2）年龄在18-70岁。", "label": 3, "label_text": "Age", "id": "s2144"}
{"text": " 10.同意参加本临床试验并自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2145"}
{"text": "1）妊娠女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2146"}
{"text": " 2)ADA检查阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2147"}
{"text": " 5.精神疾病患者；", "label": 4, "label_text": "Disease", "id": "s2148"}
{"text": " （2）肺结核、支气管扩张。", "label": 4, "label_text": "Disease", "id": "s2149"}
{"text": " 4.凝血障碍、出血倾向或术前活动性出血者;", "label": 5, "label_text": "Multiple", "id": "s2150"}
{"text": " （2）既往有慢性疾病（如高血压，糖尿病等）病史；", "label": 4, "label_text": "Disease", "id": "s2151"}
{"text": "A. 认知功能障碍的糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s2152"}
{"text": " 7）目前不合并使用类固醇激素治疗的患者，如果患者已经使用类固醇激素试验服药前至少在一个稳定的类固醇剂量下一周；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2153"}
{"text": " 4.在入选研究前的3 个月内服用其他试验药或参与了其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2154"}
{"text": " （2）合并心、脑、肝、肾、内分泌、血液等严重原发性疾病患者；", "label": 4, "label_text": "Disease", "id": "s2155"}
{"text": "1.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2156"}
{"text": " （2）18－75岁", "label": 3, "label_text": "Age", "id": "s2157"}
{"text": " ②病灶短期内扩张迅速，需要手术或介入栓塞治疗；", "label": 5, "label_text": "Multiple", "id": "s2158"}
{"text": " 1.2.FIGO分期为IIB-IIIB", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2159"}
{"text": " 2.ECOG PS评分为0-2分；", "label": 9, "label_text": "Risk Assessment", "id": "s2160"}
{"text": " 10)发病后已使用过治疗本病的其它药物者；", "label": 5, "label_text": "Multiple", "id": "s2161"}
{"text": " 7.血液系统疾病；", "label": 4, "label_text": "Disease", "id": "s2162"}
{"text": " ③年龄为18~70岁者", "label": 3, "label_text": "Age", "id": "s2163"}
{"text": " 6）患有临床意义的急性、慢性心、肾、肝、肿瘤或脑血管疾病；", "label": 4, "label_text": "Disease", "id": "s2164"}
{"text": " 6)不能定期随访的患者", "label": 8, "label_text": "Compliance with Protocol", "id": "s2165"}
{"text": " 6.符合美国《精神障碍诊断与统计手册》第五版（DSM-V）关于由于其他躯体疾病所致的抑郁障碍的诊断标准，ICD-10-CM编码为293.83[F06.32]", "label": 11, "label_text": "Diagnostic", "id": "s2166"}
{"text": "1.参试者符合变应性鼻炎中西诊断标准者，中医辨证为肺脾气虚者，西医诊断为持续性变应性鼻炎。", "label": 11, "label_text": "Diagnostic", "id": "s2167"}
{"text": " 22.有任何可能对研究治疗的安全性或疗效评估产生干扰的疾病；", "label": 4, "label_text": "Disease", "id": "s2168"}
{"text": " ②合并心脑血管、糖尿病、甲状腺疾病、肝肾疾病、癌症、肿瘤性疾病、免疫系统疾病等严重的原发性疾病或精神疾病者；", "label": 4, "label_text": "Disease", "id": "s2169"}
{"text": "     心、肝和肾功能不全者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2170"}
{"text": " 4)近3月内参加任何药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2171"}
{"text": " 3).妊娠、预近期（6个月内）妊娠、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2172"}
{"text": " 2）年龄介于18-40周岁。", "label": 3, "label_text": "Age", "id": "s2173"}
{"text": " （9）三个月内发生过严重心血管疾病：有心梗病史，或进行过冠脉搭桥或PCI手术的缺血性心脏病、充血性心衰（心功能Ⅲ-Ⅳ级，NYHA评级）患者，或有严重脑血管疾病患者（卒中及卒中后遗留明显神经系统功能障碍）；", "label": 4, "label_text": "Disease", "id": "s2174"}
{"text": " （3）术前存在气胸，肺脓肿，胸廓畸形，肺不张，肺动脉高压等肺部疾病", "label": 4, "label_text": "Disease", "id": "s2175"}
{"text": " ③出血性疾病活动期", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2176"}
{"text": " 8)2周内接受过蒙药，中药或其他传统药物治疗，以及参加过蒙医心身互动治疗的患者，需要停止2周以上才可参加本次研究。", "label": 5, "label_text": "Multiple", "id": "s2177"}
{"text": " ②近2周内接受过盆腔放疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s2178"}
{"text": "1)年龄18-70岁，BMI<34", "label": 5, "label_text": "Multiple", "id": "s2179"}
{"text": " 6.年龄：≥18岁；", "label": 3, "label_text": "Age", "id": "s2180"}
{"text": " 1)患者心肺功能较差，或因其他疾病无法耐受内镜治疗及/或静脉麻醉者。", "label": 5, "label_text": "Multiple", "id": "s2181"}
{"text": "1．签署知情同意书者，患者及家属依从性好", "label": 5, "label_text": "Multiple", "id": "s2182"}
{"text": " （4）合并有严重的糖尿病、肝肾功能不全、严重骨质疏松、器质性心脏病和心律失常、妊娠试验阳性或哺乳期妇女。", "label": 5, "label_text": "Multiple", "id": "s2183"}
{"text": " a)经化疗或干细胞移植得到缓解后,影像学（CT／MRI／PET-CT）检测到复发并经病理学确诊的淋巴瘤患者，或者出现复发(包括骨髓形态学复发和微残复发)的骨髓瘤患者或白血病患者;", "label": 5, "label_text": "Multiple", "id": "s2184"}
{"text": " ② 应用恩替卡韦治疗120周，血清 HBsAg 水平>1500IU/ml且 HBV DNA 阴性的患者；", "label": 5, "label_text": "Multiple", "id": "s2185"}
{"text": " 6.传染性疾病(如HIV、RPR、活动性结核等)；", "label": 4, "label_text": "Disease", "id": "s2186"}
{"text": " ⑥明显影响认知功能测试的视觉、听觉障碍或语言交流困难；", "label": 4, "label_text": "Disease", "id": "s2187"}
{"text": " （7）空腹TG > 2.0mmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2188"}
{"text": " 4.无性生活史者", "label": 37, "label_text": "Sexual related", "id": "s2189"}
{"text": " (9)出血归因于外阴、阴道或者宫颈，与妊娠无关。", "label": 5, "label_text": "Multiple", "id": "s2190"}
{"text": " —肌酐≤1.25倍正常值上限(ULN)", "label": 12, "label_text": "Laboratory Examinations", "id": "s2191"}
{"text": " 5、合并中枢神经系统结核的患者", "label": 4, "label_text": "Disease", "id": "s2192"}
{"text": " （15）肾功能受损，Cr超过正常上限2倍；", "label": 5, "label_text": "Multiple", "id": "s2193"}
{"text": " 6）活动性乙型肝炎或丙型肝炎病毒感染者；", "label": 4, "label_text": "Disease", "id": "s2194"}
{"text": "1.年龄大于18岁", "label": 3, "label_text": "Age", "id": "s2195"}
{"text": " （3）35≤年龄＜40岁。", "label": 3, "label_text": "Age", "id": "s2196"}
{"text": " （11）患有严重的心血管疾病伴心功能不全者；", "label": 5, "label_text": "Multiple", "id": "s2197"}
{"text": "（1）符合功能性肠病的诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s2198"}
{"text": " 2）年龄为 18—75 岁；", "label": 3, "label_text": "Age", "id": "s2199"}
{"text": " （12）研究者认为不适宜参加的其它情况。", "label": 21, "label_text": "Researcher Decision", "id": "s2200"}
{"text": " （4）三个月内参加过其他临床试验且经过筛选入组者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2201"}
{"text": " 3.对化疗药物过敏及超敏体质；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2202"}
{"text": " 2)有药物（青霉素类或头孢菌素类药物）、食物或对试验药物或类似药物过敏史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2203"}
{"text": " （3）可独立步行，配合完成步态分析测试", "label": 17, "label_text": "Capacity", "id": "s2204"}
{"text": " 3) 患者在入选前3个月之内有心肌梗死或脑卒中。", "label": 4, "label_text": "Disease", "id": "s2205"}
{"text": " (7) 法律规定的残疾患者(盲、聋、哑、智力障碍、精神障碍等)", "label": 33, "label_text": "Disabilities", "id": "s2206"}
{"text": " 7) 有参与其他临床试验依从性不良史。", "label": 8, "label_text": "Compliance with Protocol", "id": "s2207"}
{"text": " 2、根据各期临床实验目的，确定受试年龄范围40岁-70岁；", "label": 3, "label_text": "Age", "id": "s2208"}
{"text": " 10.一周内有在不易压迫止血部位的动脉穿刺。", "label": 0, "label_text": "Therapy or Surgery", "id": "s2209"}
{"text": " 5)受试者自愿受试并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2210"}
{"text": " 术前14天内肾衰竭或慢性肾病血清肌酐≥2.5mg/dl.或肾小球滤过率≤30ml/min每1.73m2或者正在接受透析的患者", "label": 5, "label_text": "Multiple", "id": "s2211"}
{"text": " 3）具有正常沟通能力。", "label": 25, "label_text": "Literacy", "id": "s2212"}
{"text": " 1、诊断明确的高血压（SBP≥130mmhg or DBP≥80mmhg），伴或者不伴有服药控制史。", "label": 11, "label_text": "Diagnostic", "id": "s2213"}
{"text": " 6）研究者评价不能入选的其他原因。", "label": 21, "label_text": "Researcher Decision", "id": "s2214"}
{"text": " c、所选病例均满足治疗前临床症状评分积分值＞10；", "label": 9, "label_text": "Risk Assessment", "id": "s2215"}
{"text": " 3、受试者的父母或法定监护人能够理解试验并配合完成所有要求；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2216"}
{"text": " 2、年龄大于等于18岁，小于80岁，男女不限。", "label": 5, "label_text": "Multiple", "id": "s2217"}
{"text": " 7.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2218"}
{"text": " 生命体征不稳定者；严重失语、失认无法沟通者；", "label": 5, "label_text": "Multiple", "id": "s2219"}
{"text": " 7）目前患急性传染病及发热性疾病。", "label": 4, "label_text": "Disease", "id": "s2220"}
{"text": " 5.医生认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s2221"}
{"text": " 4、尽管使用了ACEI或ARB类药物及皮质类固醇（≤1.0mg/kg/d的泼尼松或等效物）或免疫抑制剂。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2222"}
{"text": " （6）在研究前一个月，补充乳清蛋白粉或其他口服全营养补充剂的人；或正在参加其他营养干预项目。", "label": 5, "label_text": "Multiple", "id": "s2223"}
{"text": " (1) 年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s2224"}
{"text": " 7)具有符合实体瘤缓解评价标准（RECIST）的可测量病灶；", "label": 11, "label_text": "Diagnostic", "id": "s2225"}
{"text": " 7)育龄女性应同意在研究期间和研究结束后6个月内必须采用避孕措施（如宫内节育器，避孕药或避孕套）；在研究入组前的7天内血清或尿妊娠试验阴性，且必须为非哺乳期患者；男性应同意在研究期间和研究期结束后6个月内必须采用避孕措施的患者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2226"}
{"text": " (9)妊娠或哺乳期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2227"}
{"text": " 5.有精神及神经器质性疾病", "label": 4, "label_text": "Disease", "id": "s2228"}
{"text": " b 男方因素：少弱精子症，梗阻性无精子症", "label": 5, "label_text": "Multiple", "id": "s2229"}
{"text": " (2) 年龄分层在6-18岁之间组；", "label": 3, "label_text": "Age", "id": "s2230"}
{"text": " 3、患者同意参加本试验，配合治疗和随访，并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s2231"}
{"text": " 8)无与本方案相冲突的其他严重疾病；", "label": 4, "label_text": "Disease", "id": "s2232"}
{"text": " 3.妊娠或哺乳，或试验期间不能采取避孕措施者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2233"}
{"text": " 2、患者存在明显“不可转复迹象”，如尸僵、腐烂等；", "label": 1, "label_text": "Sign", "id": "s2234"}
{"text": " 4.眼睑异常（如睑内翻、睑外翻、肿瘤、水肿、眼睑痉挛、眼睑闭合不全、严重倒睫、严重上睑下垂影响任一眼的眼睑功能；5.眼表异常，以致可能会影响任一眼角膜的完整性（例如，以既往角膜化学伤、复发性角膜上皮糜烂、角膜上皮缺损、角膜荧光素染色3级、或地图-点状-指纹状营养不良等）", "label": 5, "label_text": "Multiple", "id": "s2235"}
{"text": " （2）严重骨缺损需先行骨增量延期植入种植体的患者；", "label": 5, "label_text": "Multiple", "id": "s2236"}
{"text": "①一秒用力呼气容积(FEV1)≤60%", "label": 12, "label_text": "Laboratory Examinations", "id": "s2237"}
{"text": " （2）年龄在1月～12岁之间，性别不限；", "label": 5, "label_text": "Multiple", "id": "s2238"}
{"text": " b）体重大于50 kg，受试者体重指数（BMI）在19～24 kg/m2 之间，包括边界值，同批体重相差不宜悬殊；", "label": 5, "label_text": "Multiple", "id": "s2239"}
{"text": " （7）存在冠脉CT检查的禁忌症；", "label": 4, "label_text": "Disease", "id": "s2240"}
{"text": " 8.手术时间＞8小时或＜4小时，体外循环时间＞3小时或＜1小时；术中心脏未完全停跳；术中二次或多次转机；临床资料不完整；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2241"}
{"text": " ⑨颅脑肿瘤术后（此次）", "label": 0, "label_text": "Therapy or Surgery", "id": "s2242"}
{"text": " 5.已接受小剂量倍他乐克缓释片（23.75mg  qd）至少1周，12导联心电图测得静息心率≥75bpm", "label": 5, "label_text": "Multiple", "id": "s2243"}
{"text": "1.年龄为30-70岁", "label": 3, "label_text": "Age", "id": "s2244"}
{"text": "(1)患者接受动脉搭桥手术或动脉瓣置换手术;", "label": 0, "label_text": "Therapy or Surgery", "id": "s2245"}
{"text": " 2. 诊断为急性呼吸道病毒感染的患者，诊断标准：", "label": 11, "label_text": "Diagnostic", "id": "s2246"}
{"text": "   任何不稳定的系统性疾病（包括活动性感染、未得到控制的高血压、不稳定型心绞痛、最近3个月内开始发作的心绞痛、充血性心功能衰竭（≥纽约心脏病协会【NYHA】 II级）、心机梗塞（入组前6个月）、需要药物治疗的严重心律失常、肝脏，肾脏或代谢性疾病；", "label": 4, "label_text": "Disease", "id": "s2247"}
{"text": " 6)有体位性低血压史者；", "label": 4, "label_text": "Disease", "id": "s2248"}
{"text": " 3、无手术条件或拒绝接受任何腹部手术者(一旦胶囊滞留将无法通过手术取出)；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2249"}
{"text": " 2）诊断为肝硬化（活检、影像学结果、临床特征）", "label": 4, "label_text": "Disease", "id": "s2250"}
{"text": " 2.年龄:18—60岁;", "label": 3, "label_text": "Age", "id": "s2251"}
{"text": " 17.在研究前筛选阶段或研究用药前、发生急性疾病。", "label": 4, "label_text": "Disease", "id": "s2252"}
{"text": "(1)父母/监护人签署书面知情同意书，并愿意配合研究过程和研究要求；", "label": 13, "label_text": "Consent", "id": "s2253"}
{"text": " 7、入选前3个月内献血者。", "label": 14, "label_text": "Blood Donation", "id": "s2254"}
{"text": "广泛型侵袭性牙周炎：参照1999年牙周病分类法国际研讨会所制定的AgP诊断标准，具体如下：", "label": 11, "label_text": "Diagnostic", "id": "s2255"}
{"text": " 7、已知的恶性肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s2256"}
{"text": " 2.初筛时血常规显示白细胞计数＞12.0×109/L，或嗜中性粒细胞百分比≥80%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2257"}
{"text": " 2)体格和实验室检查", "label": 12, "label_text": "Laboratory Examinations", "id": "s2258"}
{"text": "   2) 面部轻中度痤疮（定义为半脸皮损总数少于100，半脸炎性皮损数5-40个，不伴结节和囊肿形成）；", "label": 11, "label_text": "Diagnostic", "id": "s2259"}
{"text": " ② 至少有一个客观可评价（可测量）病灶；", "label": 4, "label_text": "Disease", "id": "s2260"}
{"text": "（1）符合乳腺增生病诊断标准，但不具备周期性乳房疼痛者。", "label": 11, "label_text": "Diagnostic", "id": "s2261"}
{"text": " （6）已签署经伦理委员会批准的干细胞移植治疗的知情同意书。", "label": 5, "label_text": "Multiple", "id": "s2262"}
{"text": " 未接受正畸、正颌、面部整形治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s2263"}
{"text": " 4.符合瘀血阻络证辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s2264"}
{"text": " ④ 孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2265"}
{"text": " 2.急性肾损伤、活动性炎症性疾病、甲状旁腺切除或确诊的恶性肿瘤患者", "label": 4, "label_text": "Disease", "id": "s2266"}
{"text": " 3．年龄18-70岁， 预期寿命大于6月", "label": 3, "label_text": "Age", "id": "s2267"}
{"text": " 2、患有不能耐受胃镜检查的疾病，包括凝血功能障碍、肾功能不全、严重的心肺疾病、荧光素钠过敏者。", "label": 5, "label_text": "Multiple", "id": "s2268"}
{"text": "1、耳部有急性感染性炎症者；", "label": 4, "label_text": "Disease", "id": "s2269"}
{"text": "（1）因骨关节炎、股骨头缺血坏死、DDH行初次全髋、全膝关节置换术患者；", "label": 5, "label_text": "Multiple", "id": "s2270"}
{"text": "  8. 不愿或不能停止在基线检查前至少一个月停止使用已知会导致干眼症的药物（如抗组胺药）的患者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2271"}
{"text": " 4.临床医生判断的不适合参加研究的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s2272"}
{"text": " 4. 结膜囊缩窄；", "label": 4, "label_text": "Disease", "id": "s2273"}
{"text": " 7)孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2274"}
{"text": " (7) Apgar评分(1 min) ≥7;", "label": 9, "label_text": "Risk Assessment", "id": "s2275"}
{"text": " 8. 不符合《中华人民共和国献血法》的规定，白细胞数＜4×10^9/L、白细胞数＞10×10^9/L、血小板数＜100×10^9/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2276"}
{"text": "（1）年龄：18~75岁；", "label": 3, "label_text": "Age", "id": "s2277"}
{"text": " 3.存在脑功能紊乱的临床症状或严重的精神性疾病不能理解或遵从研究方案；", "label": 5, "label_text": "Multiple", "id": "s2278"}
{"text": " 2.年龄40-70岁,性别不限；", "label": 5, "label_text": "Multiple", "id": "s2279"}
{"text": " 8.入组前3个月内使用过免疫抑制药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2280"}
{"text": " （5）未控制的高血压或糖尿病，严重心脑血管、肺、肝、脾、肾和造血系统疾病、肿瘤、出血性疾病和精神疾病；", "label": 4, "label_text": "Disease", "id": "s2281"}
{"text": " 3. 肝肾功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2282"}
{"text": " a.无病理性骨折的良性囊肿，病灶刮除术后的空腔性骨缺损；", "label": 4, "label_text": "Disease", "id": "s2283"}
{"text": "1、年龄18-80", "label": 3, "label_text": "Age", "id": "s2284"}
{"text": " (5)孕妇；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2285"}
{"text": " 4.假体位置不良及术后假体周围感染的患者；", "label": 4, "label_text": "Disease", "id": "s2286"}
{"text": " 4.之前无论因任何原因尝试TKI停药失败的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2287"}
{"text": "① 符合退行性脊柱侧凸症的上述诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s2288"}
{"text": " 2.患者的体格状况属ASA I～II级；", "label": 9, "label_text": "Risk Assessment", "id": "s2289"}
{"text": "1．妊娠期、哺乳期及未有效避孕措施的妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2290"}
{"text": " 3 2-8岁择期行髋关节手术儿童", "label": 5, "label_text": "Multiple", "id": "s2291"}
{"text": " (12)不能遵守中心标准饮食者；", "label": 18, "label_text": "Diet", "id": "s2292"}
{"text": " 3.增强CT和/或消化内镜提示的中、重度曲张静脉。", "label": 5, "label_text": "Multiple", "id": "s2293"}
{"text": "</bmi≤31kg>", "label": 9, "label_text": "Risk Assessment", "id": "s2294"}
{"text": "① 检查证实有脑出血、脑外伤、脑肿瘤、小脑及脑干病变等可引起手功能障碍的其他脑病；", "label": 4, "label_text": "Disease", "id": "s2295"}
{"text": " ⑦有精神疾病的患者。", "label": 4, "label_text": "Disease", "id": "s2296"}
{"text": " ②年龄20～80岁；", "label": 3, "label_text": "Age", "id": "s2297"}
{"text": " 3.近半年无酒精及药物滥用史；", "label": 2, "label_text": "Addictive Behavior", "id": "s2298"}
{"text": " 3.正在参加其他干预性研究的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2299"}
{"text": " 4)无嗜烟、嗜酒等不良嗜好，无药物滥用史。", "label": 2, "label_text": "Addictive Behavior", "id": "s2300"}
{"text": " 2、本侧乳房首次确诊为乳腺浸润性癌", "label": 4, "label_text": "Disease", "id": "s2301"}
{"text": "（1）年龄在18-70岁，ASA I-III级；", "label": 5, "label_text": "Multiple", "id": "s2302"}
{"text": " 3）试验组：病检结果显示Hp(+)且符合慢性胃炎诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2303"}
{"text": " （2）采用TP（紫杉醇+顺铂）、DP（多西他赛+顺铂）化学方案治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2304"}
{"text": " 3）ASA分级I到III级；", "label": 9, "label_text": "Risk Assessment", "id": "s2305"}
{"text": "（1）本研究开始前4周内曾参加过其他临床试验\\研究用药；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2306"}
{"text": "（1） 可根治性切除的II或III期食管鳞癌患者，而且有必要接受化疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s2307"}
{"text": " 3)有吸毒和/或酗酒史（每周饮用14个单位的酒精：1单位=啤酒285 mL，或烈酒25 mL，或葡萄酒100ml）；", "label": 2, "label_text": "Addictive Behavior", "id": "s2308"}
{"text": " 4、排除入组前1个月已经或正在接受系统的心理治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s2309"}
{"text": "黄热减毒活疫苗免疫原性研究纳入标准", "label": 11, "label_text": "Diagnostic", "id": "s2310"}
{"text": " （6）CRP超过标准上限的2倍者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2311"}
{"text": " 2) 符合高血压诊断标准的1、2、3级原发性高血压", "label": 11, "label_text": "Diagnostic", "id": "s2312"}
{"text": " 2.患有焦虑症及精神障碍的患者；", "label": 4, "label_text": "Disease", "id": "s2313"}
{"text": " 8.晚期肿瘤患者或预计1年内会死亡者；", "label": 5, "label_text": "Multiple", "id": "s2314"}
{"text": " 5.术前存在慢性疼痛或长期服用止痛药病史", "label": 5, "label_text": "Multiple", "id": "s2315"}
{"text": " 6、因其他疾病使用免疫抑制剂治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2316"}
{"text": " (1)凝血机能异常或目前正在使用抗凝药物（如阿司匹林）治疗者", "label": 5, "label_text": "Multiple", "id": "s2317"}
{"text": " （4）合并严重感染需要ICU治疗。", "label": 5, "label_text": "Multiple", "id": "s2318"}
{"text": " 13.合并恶性肿瘤患者。", "label": 4, "label_text": "Disease", "id": "s2319"}
{"text": " 11.患者合并严重肝肾功能障碍、活动性感染或其它原因无法耐受本研究所采用的治疗药物。", "label": 5, "label_text": "Multiple", "id": "s2320"}
{"text": " 6. 坐位收缩压 &lt; 180 mmHg和舒张压 &lt; 110 mmHg。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2321"}
{"text": "（1）局部或全身细菌感染急性期未能有效控制者；", "label": 4, "label_text": "Disease", "id": "s2322"}
{"text": " 7.进入研究前3年内曾诊断为任何其他恶性肿瘤，经充分治疗的基底细胞或鳞状细胞皮肤癌或宫颈原位癌除外；", "label": 4, "label_text": "Disease", "id": "s2323"}
{"text": " 7) 活动受限的心力衰竭（既往确诊，或有心衰的临床表现，经心内科会诊后确诊）、不稳定型心绞痛、既往12个月内有心肌梗死病史或其他严重心脏病患者；", "label": 4, "label_text": "Disease", "id": "s2324"}
{"text": " 5)伴有急性全身感染性疾病；", "label": 4, "label_text": "Disease", "id": "s2325"}
{"text": " （8）病情未得到控制的高血压患者；", "label": 4, "label_text": "Disease", "id": "s2326"}
{"text": " 4.完成功能性动作如肩部过头动作或外展时，会因疼痛/僵硬变得日益困难。", "label": 17, "label_text": "Capacity", "id": "s2327"}
{"text": " （11）重大头部损伤引起认知功能减退者", "label": 4, "label_text": "Disease", "id": "s2328"}
{"text": " 26. Mallampati score（马氏评分） 为3或4分；", "label": 9, "label_text": "Risk Assessment", "id": "s2329"}
{"text": " 6. 同时参加其他临床研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s2330"}
{"text": " 3. 经过病理组织学或细胞学确诊的不适宜进行根治性手术（R0）治疗，或行非根治性手术（R1），或行姑息性手术的晚期，或复发转移性肝外胆管癌或胆囊癌患者；", "label": 5, "label_text": "Multiple", "id": "s2331"}
{"text": " 5)试验前已经详细了解试验性质、意义、可能的获益，可能带来的不便和潜在的风险与不适，并自愿参加本次临床试验，能与研究者良好沟通，遵从整个研究的要求，且签署了书面的知情同意书。", "label": 5, "label_text": "Multiple", "id": "s2332"}
{"text": " 5. 对舒肝宁注射液组方药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2333"}
{"text": "1、药物及手术干预无效的严重宫腔粘连或子宫内膜瘢痕化患者；", "label": 4, "label_text": "Disease", "id": "s2334"}
{"text": "a．有全身系统疾病史；", "label": 4, "label_text": "Disease", "id": "s2335"}
{"text": " 3，心衰/肝肾功能不全;", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2336"}
{"text": " 10. 在研究给药前至少一个月内服用了任何药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2337"}
{"text": " 3、使用可能改变实验指标的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2338"}
{"text": " （2）自愿受试，签署知情同意书，能够配合采集临床资料者；", "label": 5, "label_text": "Multiple", "id": "s2339"}
{"text": " （4）免疫系统疾病", "label": 4, "label_text": "Disease", "id": "s2340"}
{"text": " （3）肝功能Child-pugh评分为A或B级；", "label": 9, "label_text": "Risk Assessment", "id": "s2341"}
{"text": " 3)已知艾滋病毒的血清学反应为阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2342"}
{"text": " （3）年龄在 15－45 岁之间，病程 3 个月以上，性别不限。", "label": 5, "label_text": "Multiple", "id": "s2343"}
{"text": " 2、孕妇或者福如期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2344"}
{"text": " 8.排除有明显的肺部良性结节指征的人群：结核/炎症指标阳性；", "label": 5, "label_text": "Multiple", "id": "s2345"}
{"text": " ⑷葡萄膜炎；", "label": 4, "label_text": "Disease", "id": "s2346"}
{"text": " 2. 碘造影剂、他汀类药物过敏，术前一直服用他汀类药物；", "label": 5, "label_text": "Multiple", "id": "s2347"}
{"text": " 3、愿意参加本研究，签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2348"}
{"text": " （4）ESSDAI≥4分；", "label": 9, "label_text": "Risk Assessment", "id": "s2349"}
{"text": " ③正在参与干预性临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s2350"}
{"text": " 8.高血压病史且入室血压收缩压&gt;180或舒张压&gt;110mmHg连续两次测量未下降；", "label": 5, "label_text": "Multiple", "id": "s2351"}
{"text": " （2）年龄在18~65岁（含）", "label": 3, "label_text": "Age", "id": "s2352"}
{"text": " 5、诊断为炎性肠病者；", "label": 4, "label_text": "Disease", "id": "s2353"}
{"text": "①无法在入ICU24-48h获得大便的任何情况", "label": 17, "label_text": "Capacity", "id": "s2354"}
{"text": " 8.   患有严重的自身免疫疾病或者免疫缺陷疾病；", "label": 4, "label_text": "Disease", "id": "s2355"}
{"text": "（1）经病理诊断确诊为非小细胞肺癌，TNM分期在IIB以上者；", "label": 5, "label_text": "Multiple", "id": "s2356"}
{"text": " f)研究者根据患者病史，全面的体格检查，实验室检查，生命体征检查等判定受试者符合试验要求；", "label": 5, "label_text": "Multiple", "id": "s2357"}
{"text": " 13)妊娠期、哺乳期妇女或近期有生育计划者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2358"}
{"text": "⑴有行经皮胃造瘘或空肠造瘘指征者；", "label": 4, "label_text": "Disease", "id": "s2359"}
{"text": " 12.其他研究者认为不适合参加研究的患者", "label": 21, "label_text": "Researcher Decision", "id": "s2360"}
{"text": " （5）白蛋白＜30g/L者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2361"}
{"text": " （2）怀孕期或哺乳期或者近期计划生育的受试者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2362"}
{"text": " ④签署知情同意书", "label": 13, "label_text": "Consent", "id": "s2363"}
{"text": " ②有慢性乙型肝炎或代偿期乙型肝炎肝硬化基础者；", "label": 4, "label_text": "Disease", "id": "s2364"}
{"text": " (10)目前正在参加其他临床试验者，或既往30日内参加过其他临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s2365"}
{"text": " （6）活动期肿瘤（进展期、转移或6个月内曾因此接受治疗）；", "label": 5, "label_text": "Multiple", "id": "s2366"}
{"text": "1）拟行上消化道早癌粘膜下剥离术（ESD）患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2367"}
{"text": " 7．有阿片类镇痛药、镇静催眠药及酒精滥用史者；", "label": 2, "label_text": "Addictive Behavior", "id": "s2368"}
{"text": " 9 育龄期妇女妊娠尿检阴性并同意在研究期间使用高效避孕措施。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2369"}
{"text": "年龄18岁及以上；", "label": 3, "label_text": "Age", "id": "s2370"}
{"text": " （3）妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2371"}
{"text": " 4. 患者和家属知情并同意合作者。", "label": 13, "label_text": "Consent", "id": "s2372"}
{"text": " 3. HP感染但未经合理评估", "label": 4, "label_text": "Disease", "id": "s2373"}
{"text": " （4）合并有其他眼病。", "label": 4, "label_text": "Disease", "id": "s2374"}
{"text": " 4)预期寿命至少为3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s2375"}
{"text": " 4）访视1前4周内发生影响血糖控制的急性感染，或其他可能影响试验疗效和安全性的并发疾病", "label": 4, "label_text": "Disease", "id": "s2376"}
{"text": " （6）对上述试验药物过敏或者有禁忌证者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2377"}
{"text": " 3. 术前评估发现存在任何远处转移（M1）的情况", "label": 24, "label_text": "Neoplasm Status", "id": "s2378"}
{"text": " 4) 既往有肺结节未能确诊者。", "label": 11, "label_text": "Diagnostic", "id": "s2379"}
{"text": " 2 性别年龄体重不限", "label": 5, "label_text": "Multiple", "id": "s2380"}
{"text": " 8) 女性妊娠患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2381"}
{"text": " 2.合并其他心脏疾病、神经官能症、更年期综合征、甲状腺功能亢进、脊髓型或椎动脉型颈椎病、胃-食管返流病或食道裂孔疝等可能引起胸痛的疾病;", "label": 4, "label_text": "Disease", "id": "s2382"}
{"text": " 6)神经肌肉性疾病。", "label": 4, "label_text": "Disease", "id": "s2383"}
{"text": " 1、年龄≥40岁；", "label": 3, "label_text": "Age", "id": "s2384"}
{"text": " 3.肾功能不全患儿。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2385"}
{"text": " 2 选择第6～21天为亚急性期，21天后为慢性期各种类型的脑梗塞患者。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2386"}
{"text": " 3.1月内腹膜炎、出口或隧道感染", "label": 4, "label_text": "Disease", "id": "s2387"}
{"text": " 2)性别：男性。", "label": 35, "label_text": "Gender", "id": "s2388"}
{"text": "a.不能耐受气管镜检查；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2389"}
{"text": "     A. 计划在试验后14天内完成冠脉造影检查的患者", "label": 34, "label_text": "Device", "id": "s2390"}
{"text": " 2）平素体健，无高血压、糖尿病等疾病病史；", "label": 4, "label_text": "Disease", "id": "s2391"}
{"text": " 2)外伤引起的脊柱痛、关节痛", "label": 4, "label_text": "Disease", "id": "s2392"}
{"text": " 5）患者知情同意。", "label": 13, "label_text": "Consent", "id": "s2393"}
{"text": " 5）明显的听力或视力障碍，不能完成问卷调查和检查评估者；", "label": 5, "label_text": "Multiple", "id": "s2394"}
{"text": " 5.妊娠或哺乳期妇女（有生育潜能的妇女必须在研究开始前获取妊娠试验阴性的结果，并采用医学上认可的避孕措施）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2395"}
{"text": " a)具有NPC放射治疗史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2396"}
{"text": " ②PLT＜50×109/L或有内脏出血倾向的患者。", "label": 5, "label_text": "Multiple", "id": "s2397"}
{"text": " 5. 肝肾功能正常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2398"}
{"text": " 6.患有出血性倾向的疾病；", "label": 4, "label_text": "Disease", "id": "s2399"}
{"text": " 2.近期（2周内）有流感、腹泻等急症者或有服用抗菌药物的。", "label": 5, "label_text": "Multiple", "id": "s2400"}
{"text": " 2)过敏体质（不包括轻度无症状的季节性过敏），或已知（包括怀疑）对活性成分紫杉醇或及其辅料、白蛋白过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s2401"}
{"text": "1）受试者年龄18-80岁", "label": 3, "label_text": "Age", "id": "s2402"}
{"text": " 5）无心脑等重要脏器功能障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2403"}
{"text": " 3.不能够完成本研究或随访研究的受试者。", "label": 17, "label_text": "Capacity", "id": "s2404"}
{"text": " （2）胃镜检查确诊的慢性胃炎，伴或不伴已愈合的胃溃疡或十二指肠球部溃疡。", "label": 11, "label_text": "Diagnostic", "id": "s2405"}
{"text": "一，因宫颈癌诊断或治疗，需要进行宫颈组织活检或子宫切除的CIN和宫颈癌患者。", "label": 5, "label_text": "Multiple", "id": "s2406"}
{"text": "1、年龄大于18岁；男女不限。", "label": 5, "label_text": "Multiple", "id": "s2407"}
{"text": " 5) 正在接受靶向药物、免疫抑制剂、免疫调节剂、 生物治疗患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2408"}
{"text": " 6)肝功能Child分级A或B级；", "label": 9, "label_text": "Risk Assessment", "id": "s2409"}
{"text": " （4）正规运动康复治疗5年以上上肢功能恢复不满意，继续恢复已停止；", "label": 5, "label_text": "Multiple", "id": "s2410"}
{"text": "1.全身情况不适合种植者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2411"}
{"text": "1.感染性关节炎、痛风性关节炎、类风湿关节炎、外伤性关节炎等;", "label": 4, "label_text": "Disease", "id": "s2412"}
{"text": " b.未按规定治疗，无法判断疗效等影响疗效判断者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2413"}
{"text": " 3、依从性差者：因工作特殊、脑功能减退，或中重度痴呆", "label": 5, "label_text": "Multiple", "id": "s2414"}
{"text": " 3、ICU住院时间小于48小时；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2415"}
{"text": " (2) 患者不愿意接受临床资料调查。", "label": 13, "label_text": "Consent", "id": "s2416"}
{"text": " 8.近1个月内参加过其他药物或医疗器械临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2417"}
{"text": " 3.在随机分组前已决定行冻胚移植者，如拟处理输卵管积水，促排卵过程中孕激素高，以及OHSS高风险者等；", "label": 5, "label_text": "Multiple", "id": "s2418"}
{"text": " ③HIV阳性或免疫功能异常；", "label": 5, "label_text": "Multiple", "id": "s2419"}
{"text": " （2）年龄20～45（含20、45）周岁；", "label": 3, "label_text": "Age", "id": "s2420"}
{"text": "     6) 凝血参数（PT、APTT在正常范围）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2421"}
{"text": " ②多次复发，病情进展。", "label": 5, "label_text": "Multiple", "id": "s2422"}
{"text": " 6、自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2423"}
{"text": " （2）既往有肝脏疾病；", "label": 4, "label_text": "Disease", "id": "s2424"}
{"text": " 8）肌酐清除率（CrCl）＞50 mL/min。肌酐清除率计算Cockcroft-Gault公式：CrCl=[(140-年龄)×体重(kg)]/[0.814×Scr (umol/L)]。内生肌酐清除率计算过程中应注意肌酐的单位；女性按计算结果×0.85 [6,7]。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2425"}
{"text": " 3.病程&lt;72h；", "label": 4, "label_text": "Disease", "id": "s2426"}
{"text": "1.存在精神疾患及认知障碍者、临终或身体状况不能完成调查者；", "label": 4, "label_text": "Disease", "id": "s2427"}
{"text": " ④ 无麻醉药物过敏史。", "label": 7, "label_text": "Allergy Intolerance", "id": "s2428"}
{"text": " 11.嗜酒者", "label": 2, "label_text": "Addictive Behavior", "id": "s2429"}
{"text": " ⑦骨髓储备：中性粒细胞计数≥ 1.5×109/L, 血小板≥ 100×109/L。血红蛋白≥100g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2430"}
{"text": "1.孕妇怀孕期间服用铁剂、叶酸或其他营养素超过两周；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2431"}
{"text": " (8)筛选前6个月内曾发生低血糖昏迷者；", "label": 4, "label_text": "Disease", "id": "s2432"}
{"text": " 1）经过病史和甲功八项、TRAb抗体、甲状腺B超检测确定为难治性GD患者；", "label": 4, "label_text": "Disease", "id": "s2433"}
{"text": " 4. 使用高于替代剂量的激素或者免疫抑制疗法大于一月；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2434"}
{"text": " 11)既往有化疗史，或做过肺叶切除或全叶切除。", "label": 0, "label_text": "Therapy or Surgery", "id": "s2435"}
{"text": " 4)乙型肝炎表面抗原检测阳性、活动性肝炎者；", "label": 5, "label_text": "Multiple", "id": "s2436"}
{"text": " 2.既往有上消化道手术病史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2437"}
{"text": " （2）妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2438"}
{"text": " 9)伴有胸腔积液积液/腹水达到800ml以上或者胸腔积液/腹水导致呼吸道综合征(按NCI CTC AE4.03分级≥2级呼吸困难。[2级呼吸困难指少量活动时呼吸短促；影响工具性日常生活活动])；", "label": 5, "label_text": "Multiple", "id": "s2439"}
{"text": " 13.患有不易控制的精神病史者；", "label": 4, "label_text": "Disease", "id": "s2440"}
{"text": "（1）主因口腔颌面部恶性肿物就诊，拟行单侧或双侧颈淋巴清扫术者；", "label": 5, "label_text": "Multiple", "id": "s2441"}
{"text": " ⑸ 合并有直肠脱垂、肛裂、肛周脓肿或肛瘘等疾病者；", "label": 4, "label_text": "Disease", "id": "s2442"}
{"text": " 10.急性风湿热、心内膜炎等导致的心源性卒中患者，或脑部感染、脑外伤、肿瘤、癫痫等导致的卒中；", "label": 4, "label_text": "Disease", "id": "s2443"}
{"text": "1.年龄在18-65岁；", "label": 3, "label_text": "Age", "id": "s2444"}
{"text": " 2)P-R间期＞240ms的Ⅰ度房室传导阻滞的患者；", "label": 4, "label_text": "Disease", "id": "s2445"}
{"text": " 2、临床上拟诊为特发性炎性肌病或糖尿病；", "label": 4, "label_text": "Disease", "id": "s2446"}
{"text": "1.年龄≥65 岁", "label": 3, "label_text": "Age", "id": "s2447"}
{"text": " 11.严重活动性临床感染（&gt; 2级，NCI-CTCAE 版本4.0），HBV和HCV感染除外", "label": 4, "label_text": "Disease", "id": "s2448"}
{"text": " 3.疑有肝硬化、肝细胞癌患者", "label": 4, "label_text": "Disease", "id": "s2449"}
{"text": " 5.拒绝接受相关治疗方案或随访方案；", "label": 5, "label_text": "Multiple", "id": "s2450"}
{"text": " （3）患者签署知情同意书，并有条件随诊者。", "label": 5, "label_text": "Multiple", "id": "s2451"}
{"text": " （3）中医辨证为精血亏虚证；", "label": 11, "label_text": "Diagnostic", "id": "s2452"}
{"text": " 5 患者必须满足所有以下条件：白细胞计数在4,000～10,000/mm3； 中性粒细胞计数≥2,000/mm3； 血小板计数 ≥100,000/mm3； 血红蛋白 ≥11.0g/dL；谷草转氨酶 (AST) 和谷丙转氨酶(ALT) ≤1.5 倍的正常值上限； 总胆红素 ≤24umol/L 和血肌酐≤85umol/L。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2453"}
{"text": " 3.未予生物制剂、免疫抑制剂治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2454"}
{"text": " （3）人类免疫缺陷病毒（HIV）阳性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2455"}
{"text": " 5. 严重畸形或染色体异常的患儿。", "label": 4, "label_text": "Disease", "id": "s2456"}
{"text": "1）符合《艾滋病和艾滋病病毒感染诊断标准》（WS293-2008）的HIV感染者诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2457"}
{"text": " 10. 既往对同类药物不耐受或过敏史", "label": 7, "label_text": "Allergy Intolerance", "id": "s2458"}
{"text": " （5）有心电图运动负荷试验的相对或绝对禁忌症：左冠状动脉主干狭窄、中重度狭窄的瓣膜性心脏病、电解质异常、严重高血压、肥厚型心肌病或其它形式的流出道梗阻等。", "label": 4, "label_text": "Disease", "id": "s2459"}
{"text": " 3、窝沟有龋损能卡住探针", "label": 5, "label_text": "Multiple", "id": "s2460"}
{"text": "年龄&gt;18岁，≤75岁；", "label": 3, "label_text": "Age", "id": "s2461"}
{"text": " （2）年龄小于18周岁，大于80周岁的患者", "label": 3, "label_text": "Age", "id": "s2462"}
{"text": " 4.有失语、感觉障碍;", "label": 4, "label_text": "Disease", "id": "s2463"}
{"text": " 6、其他原因需要行PGD、PGS者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2464"}
{"text": " 3.无严重内科疾病（重要脏器功能在正常范围）", "label": 4, "label_text": "Disease", "id": "s2465"}
{"text": "1.符合诊断标准，确诊为高危妊娠患者。", "label": 11, "label_text": "Diagnostic", "id": "s2466"}
{"text": " 17）每天饮用过量茶、咖啡或含咖啡因的饮料；", "label": 18, "label_text": "Diet", "id": "s2467"}
{"text": "1.ⅠA2 to ⅡA的早期宫颈癌患者。", "label": 4, "label_text": "Disease", "id": "s2468"}
{"text": " 3.无神经肌肉疾病", "label": 4, "label_text": "Disease", "id": "s2469"}
{"text": " ④ 血红蛋白＜9g/dL，白细胞计数＜2.5×109/L，中性粒细胞数＜1.5×109/L，血小板数＜50×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2470"}
{"text": " 5)有吞咽困难或任何影响药物吸收的胃肠道疾病史；", "label": 4, "label_text": "Disease", "id": "s2471"}
{"text": " 6. 在筛选/入组时存在有临床意义的感染。", "label": 4, "label_text": "Disease", "id": "s2472"}
{"text": " ⑤肩关节先天性异常；", "label": 4, "label_text": "Disease", "id": "s2473"}
{"text": " 4) 60岁≤年龄≤89岁；", "label": 3, "label_text": "Age", "id": "s2474"}
{"text": "1)受试者必须理解临床试验并自愿参加，同时签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2475"}
{"text": "1.男性或女性，年龄≥18岁；", "label": 5, "label_text": "Multiple", "id": "s2476"}
{"text": " 2）年龄1-40周岁；", "label": 3, "label_text": "Age", "id": "s2477"}
{"text": " 2）不能控制的疾病如严重高血压或糖尿病等；", "label": 4, "label_text": "Disease", "id": "s2478"}
{"text": " 5.自身免疫缺陷患者或患有其它获得性、先天性免疫缺陷疾病；", "label": 4, "label_text": "Disease", "id": "s2479"}
{"text": " （4）有严重心、肺、肾疾病，精神病患者", "label": 4, "label_text": "Disease", "id": "s2480"}
{"text": " 4.患者自愿参加本研究并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2481"}
{"text": " 7. 根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，如工作环境经常变动等易造成失访的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s2482"}
{"text": " (8)血小板增多症及血小板减少症；", "label": 4, "label_text": "Disease", "id": "s2483"}
{"text": " 8.视网膜或眼底存在病变的患者；", "label": 4, "label_text": "Disease", "id": "s2484"}
{"text": "1. ≥18岁，&lt;70岁", "label": 3, "label_text": "Age", "id": "s2485"}
{"text": " 2）有严重的肺功能损害性疾病史", "label": 4, "label_text": "Disease", "id": "s2486"}
{"text": " 6、既往有凝血功能异常史或相关血液系统疾病史者，如血友病、白血病等；", "label": 4, "label_text": "Disease", "id": "s2487"}
{"text": " 2.异基因造血干细胞移植后复发", "label": 5, "label_text": "Multiple", "id": "s2488"}
{"text": "1)能够理解研究流程，自愿参加本项研究，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2489"}
{"text": " 4.存在交流障碍", "label": 25, "label_text": "Literacy", "id": "s2490"}
{"text": " 2.体格检查、实验室检查、心电图（ECG）、胸片、生命体征检查等提示受试者存在被研究者判定为有临床意义的异常；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2491"}
{"text": " 8.2010年1月1日和2015年12月31日之间接受过肝转移病灶手术治疗，包括肝切除术、射频消融、或MCT（微波消融）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2492"}
{"text": " 3）ASA 分级I-II级", "label": 9, "label_text": "Risk Assessment", "id": "s2493"}
{"text": " 6．肾功能检查：血清肌酐（Cr）&gt;1.5倍正常值上限；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2494"}
{"text": " 2.健康者", "label": 32, "label_text": "Healthy", "id": "s2495"}
{"text": " 6）ECOG评分必须为0或1；", "label": 9, "label_text": "Risk Assessment", "id": "s2496"}
{"text": " 6.每周使用电脑时间不少于20 小时；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s2497"}
{"text": "(1)继发性ITP；", "label": 4, "label_text": "Disease", "id": "s2498"}
{"text": " （2）符合银屑病血瘀证的辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s2499"}
{"text": " (8)试验开始前两周内使用过任何其他药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2500"}
{"text": "①合并有严重的心、肝、肾和造血系统等疾病，以及恶性肿瘤、精神病患者；", "label": 4, "label_text": "Disease", "id": "s2501"}
{"text": " d.HIV血清学检查阴性", "label": 12, "label_text": "Laboratory Examinations", "id": "s2502"}
{"text": " 13)肾功能：血清肌酐≤1.5倍正常值上限；", "label": 5, "label_text": "Multiple", "id": "s2503"}
{"text": "?1. 术前经胃镜和活检证实的胃腺癌患者，原发病灶位于胃上部和/或中部，食管腹段未受累，预计可行根治性全胃切除术；", "label": 5, "label_text": "Multiple", "id": "s2504"}
{"text": "（1）心肌缺血的临床症状", "label": 28, "label_text": "Symptom", "id": "s2505"}
{"text": "    （5）妊娠或哺乳期妇女，过敏体质者；", "label": 5, "label_text": "Multiple", "id": "s2506"}
{"text": " （2）年龄40～75岁，身体状况评分ECOG 0～1，预计生存期≥12个月；", "label": 5, "label_text": "Multiple", "id": "s2507"}
{"text": "1.先前的膝关节损伤或手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s2508"}
{"text": " 7.妊娠期、哺乳期妇女及准备妊娠者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2509"}
{"text": " (3) 重症急性胰腺炎（severe acute pancreatitis，SAP）患者，根据改良后亚特兰大急性胰腺炎分类标准，SAP的诊断标准如下(满足以下任何1条)：", "label": 11, "label_text": "Diagnostic", "id": "s2510"}
{"text": " 13）研究者认为不适宜入组的其它情况", "label": 21, "label_text": "Researcher Decision", "id": "s2511"}
{"text": " 2. 需要使用呼吸机机械通气或需要持续正压给氧治疗（CPAP）的患儿。", "label": 38, "label_text": "Nursing", "id": "s2512"}
{"text": "        a)有下肢或骶部指凹性水肿；", "label": 1, "label_text": "Sign", "id": "s2513"}
{"text": " 14）凝血功能：国际标准化比值（INR）≤1.5倍正常值上限，凝血酶原时间（PT）或活化部分凝血活酶时间（APTT）≤1.5倍正常值上限。", "label": 5, "label_text": "Multiple", "id": "s2514"}
{"text": "（1）原位癌或合并其他肿瘤的患者", "label": 4, "label_text": "Disease", "id": "s2515"}
{"text": " 3.非治愈伤口、处于活动期的消化性溃疡或骨折。", "label": 4, "label_text": "Disease", "id": "s2516"}
{"text": " 6.任何时候接受过阿扎胞苷或地西他滨的治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2517"}
{"text": " 5. 同时存在其他恶性肿瘤。", "label": 4, "label_text": "Disease", "id": "s2518"}
{"text": " （8）  志愿参加，签署知情同意书，并经伦理委员会的同意。", "label": 5, "label_text": "Multiple", "id": "s2519"}
{"text": " ③术后病理却认为转移瘤；", "label": 4, "label_text": "Disease", "id": "s2520"}
{"text": " （4）甲状腺癌家族史", "label": 4, "label_text": "Disease", "id": "s2521"}
{"text": " 3 长期服用激素患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2522"}
{"text": " 3.研究期间允许1~2次全身糖皮质激素使用", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2523"}
{"text": " 5) 体内含有金属起搏器或其他金属医疗植入物，如人工金属关节", "label": 34, "label_text": "Device", "id": "s2524"}
{"text": "1.收集自体检科的体检人群样本，表观健康，尿常规、影像学结果正常，综合体检报告结果正常为判定标准，年龄层次分布应与尿路上皮癌病例组大体相同。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2525"}
{"text": " （2）术前处于炎症反应期、长期使用激素史及急诊手术者；", "label": 5, "label_text": "Multiple", "id": "s2526"}
{"text": " 13.患者或家属不同意参与研究，或不能理解、不能配合研究", "label": 13, "label_text": "Consent", "id": "s2527"}
{"text": "失眠症患者纳入标准：", "label": 4, "label_text": "Disease", "id": "s2528"}
{"text": " 3. 不能口服或者进食的患者；", "label": 17, "label_text": "Capacity", "id": "s2529"}
{"text": " 3.治疗前3个月内未接受除饮食运动以外的其他任何方式的减肥治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2530"}
{"text": " 3.既往或同时患有其它未治愈的恶性肿瘤，已治愈的皮肤基底细胞癌、宫颈原位癌和浅表性膀胱癌除外；", "label": 4, "label_text": "Disease", "id": "s2531"}
{"text": " （5）既往确诊为精神分裂症、双相情感障碍、焦虑症、抑郁症等精神疾病或合并躯体化障碍的患者；", "label": 4, "label_text": "Disease", "id": "s2532"}
{"text": " 5、入组时已经存在VAP", "label": 4, "label_text": "Disease", "id": "s2533"}
{"text": " 5.肾功能：BUN和Cr≤1.5倍正常值上限，肌酐清除率≥80mL/min；", "label": 5, "label_text": "Multiple", "id": "s2534"}
{"text": " 6. 曾接受过细胞毒性药物化疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2535"}
{"text": "1．3个月内有心肌梗死或血管重建史，重度心肺功能不全（心功能﹥Ⅱ级）、重度心律失常（快速房颤、房扑、阵发性室速等）者；", "label": 5, "label_text": "Multiple", "id": "s2536"}
{"text": " ③血清ALT水平在正常上限的1.5倍至10倍之间；或血清纤维化4项中有2项同时高于正常上限的1.2倍；或肝组织病理学提示炎症G≥2或纤维化S≥2。", "label": 5, "label_text": "Multiple", "id": "s2537"}
{"text": " 4. 既往有盆腔手术或外伤史，经研究者判断影响药物疗效评价者；", "label": 5, "label_text": "Multiple", "id": "s2538"}
{"text": " 4.一方接触致畸量的射线、毒物、药品并处于作用期。", "label": 5, "label_text": "Multiple", "id": "s2539"}
{"text": " 3）育龄妇女在给药开始前尿妊娠试验阴性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2540"}
{"text": " 5)心功能正常：EF&gt;50%", "label": 5, "label_text": "Multiple", "id": "s2541"}
{"text": " 6、妊娠前有其他严重疾病患者，如严重肝肾功能不全、心肺功能不全者；", "label": 5, "label_text": "Multiple", "id": "s2542"}
{"text": " 3.贫血、正铁血红蛋白血症及低氧血症减低心肌供氧而致心绞痛者。", "label": 4, "label_text": "Disease", "id": "s2543"}
{"text": " 严重精神疾病者；", "label": 4, "label_text": "Disease", "id": "s2544"}
{"text": "       ① 频繁抽搐、昏迷、脑疝；", "label": 4, "label_text": "Disease", "id": "s2545"}
{"text": " 2.有磁共振禁忌症。", "label": 4, "label_text": "Disease", "id": "s2546"}
{"text": " （5）凝血功能不全，有严重出血倾向，不能抗凝治疗或抗凝禁忌；", "label": 5, "label_text": "Multiple", "id": "s2547"}
{"text": "1) 年龄：18 ~70 岁，女性；", "label": 5, "label_text": "Multiple", "id": "s2548"}
{"text": " 4.服用硝酸酯类药物患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2549"}
{"text": " 2.洼田饮水试验≥2级", "label": 9, "label_text": "Risk Assessment", "id": "s2550"}
{"text": " 4. 其他有关肺部疾病（例如： 有经CT诊断的主支气管扩张症、囊性肺纤维化、毛细支气管炎、肺切除、肺癌、间质性肺病【例如纤维化、矽肺、肉瘤样病】病史，或活动性结核病）；", "label": 4, "label_text": "Disease", "id": "s2551"}
{"text": " ③脑卒中首次发病，发病时间为≤4个月，首次入我院治疗；", "label": 4, "label_text": "Disease", "id": "s2552"}
{"text": "①胸部CT检测提示肺部结节病灶。", "label": 5, "label_text": "Multiple", "id": "s2553"}
{"text": " 3 目前治疗：胰岛素或者胰岛素类似物使用量＞40IU/日，口服药小于两种，可以是胰岛素促分泌剂、二甲双胍、阿卡波糖、胰岛素增敏剂中一种或任意两种，剂量小于次大剂量（二甲双胍≤1000mg,阿卡波糖≤150mg，磺脲类或格列奈类小于最大剂量的一半）且稳定用药三个月以上。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2554"}
{"text": " 9. 有生殖能力的男性或有怀孕可能性的女性，必须在试验过程中使用高度有效的避孕方法（如口服避孕药、宫内避孕器、节制性欲或屏障避孕法结合杀精剂），且在治疗结束后继续避孕3 个月。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2555"}
{"text": "1)肾脏病理表现：间质纤维化&gt;50%；", "label": 5, "label_text": "Multiple", "id": "s2556"}
{"text": " 12)  存在EPO抵抗的患者；EPO抵抗指皮下注射rHuEPo达到300IU／(kg?wk)(总量20000IU／wk)或静脉注射rHuEPO500IU／(kg?wk)(总量30000Iu／周)治疗4个月后，Hb仍不能达到或维持靶目标值；", "label": 5, "label_text": "Multiple", "id": "s2557"}
{"text": " 3、合并严重的肺、肝、肾功能障碍，内分泌系统、造血系统等严重原发性疾病者。", "label": 5, "label_text": "Multiple", "id": "s2558"}
{"text": "①凝血功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2559"}
{"text": " 2.孕妇怀孕时，孕周小于24孕周。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2560"}
{"text": " 5、脑出血半年内、出血性疾病或明确的出血倾向", "label": 4, "label_text": "Disease", "id": "s2561"}
{"text": "1.符合2型糖尿病诊断标准，病程不限", "label": 11, "label_text": "Diagnostic", "id": "s2562"}
{"text": " 19)在服用研究用药前48小时内服用过任何含酒精的制品。", "label": 39, "label_text": "Alcohol Consumer", "id": "s2563"}
{"text": " 4、近3个月内参加过其它药物研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s2564"}
{"text": " g)病人能够理解研究方案并愿意参与本研究，签署书面知情同意", "label": 13, "label_text": "Consent", "id": "s2565"}
{"text": "1)3个月内出现由门脉高压导致的上消化道出血者；", "label": 4, "label_text": "Disease", "id": "s2566"}
{"text": " 3.急性或慢性的严重肾损伤（GFR&lt;30ml/min/1.73m2）患者；", "label": 4, "label_text": "Disease", "id": "s2567"}
{"text": "(1)受试者存在心脏、肝、肾、胃肠系统、呼吸系统、神经系统、造血功能、内分泌功能异常或其他研究者判断为有临床意义的异常。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2568"}
{"text": " ?病人有其他的胃恶性疾病，如淋巴瘤和间质瘤等；", "label": 4, "label_text": "Disease", "id": "s2569"}
{"text": " 3、签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2570"}
{"text": " 3. 多囊卵巢综合征的患者", "label": 4, "label_text": "Disease", "id": "s2571"}
{"text": " 6、有酗酒史的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s2572"}
{"text": "(1)合并有消化性溃疡、胃黏膜重度异型增生或病理诊断疑有恶变者；", "label": 11, "label_text": "Diagnostic", "id": "s2573"}
{"text": "1.合并患有心、肺、脑等重要脏器疾病者。", "label": 4, "label_text": "Disease", "id": "s2574"}
{"text": " ③　发病1周以内的新鲜骨折者；", "label": 4, "label_text": "Disease", "id": "s2575"}
{"text": " 12)分组前 28 天内接受了重大外科治疗、切开活检或明显创伤性损伤；", "label": 5, "label_text": "Multiple", "id": "s2576"}
{"text": " ②自愿进行初次鼻整形或鼻修复术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2577"}
{"text": " 3.年龄：18岁-70岁，KPS评分大于70分；", "label": 3, "label_text": "Age", "id": "s2578"}
{"text": "  6) 器官移植或拟进行器官移植者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2579"}
{"text": " 12. 已经参加其它研究者（仅指所参加项目不允许参加本研究者）；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2580"}
{"text": "1)试验前3个月每日吸烟量多于5支者。", "label": 36, "label_text": "Smoking Status", "id": "s2581"}
{"text": " ⑵ 长期服用有关治疗RA的药物，且在本研究前至少1个月内未停用相关免疫抑制药或抗癌药如甲氨喋呤等的患者，以及本研究前1个月内曾服用与本研究用药相同的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2582"}
{"text": " F.抗尿失禁：阴道无张力尿道中段悬吊带术", "label": 0, "label_text": "Therapy or Surgery", "id": "s2583"}
{"text": " ③1×ULN≤ALT&lt;2×ULN。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2584"}
{"text": " (11) 体内植入起搏器的患者;", "label": 34, "label_text": "Device", "id": "s2585"}
{"text": " 9.患者有青光眼病史或青光眼可疑", "label": 4, "label_text": "Disease", "id": "s2586"}
{"text": " （18）通过外科切开（而非穿刺）建立血管入路", "label": 0, "label_text": "Therapy or Surgery", "id": "s2587"}
{"text": "①胆总管结石合并其他胆道疾病者或肿瘤者；", "label": 4, "label_text": "Disease", "id": "s2588"}
{"text": " 6、合并其他系统疾病", "label": 4, "label_text": "Disease", "id": "s2589"}
{"text": " 2.手术后少于6周；或者在研究过程中计划进行手术者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s2590"}
{"text": " 2、对本试验观察的药物过敏或不能耐受者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2591"}
{"text": " 13、有明显出血倾向及血液系统疾病的患者；", "label": 4, "label_text": "Disease", "id": "s2592"}
{"text": " 2.光敏感或可能因光诱发癫痫者。", "label": 4, "label_text": "Disease", "id": "s2593"}
{"text": " 6.妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2594"}
{"text": " 4.计划怀孕、妊娠期、哺乳期妇女，绝经期妇女（冠心病高风险人群）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2595"}
{"text": "（1）年龄为16至70岁,男女不限；", "label": 5, "label_text": "Multiple", "id": "s2596"}
{"text": " (7)妊娠期，哺乳期或有妊娠可能以及计划妊娠的患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2597"}
{"text": " 8.既往有明确的神经或精神障碍史，包括癫痫或痴呆；", "label": 4, "label_text": "Disease", "id": "s2598"}
{"text": " ③明显肝肾疾病的症状和体征，或丙氨酸氨基转移酶（ALT）高于正常上限的2倍者，血清肌酐大于正常上限者", "label": 5, "label_text": "Multiple", "id": "s2599"}
{"text": " 5. 愿意签署知情同意书并严格准守临床方案。", "label": 13, "label_text": "Consent", "id": "s2600"}
{"text": " (9)筛选前诊断为肝脏恶性肿瘤或其他未治愈的恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s2601"}
{"text": " 4)其他严重的可能限制患者参加此试验的疾病（例如进展期感染、不能控制的糖尿病、严重的心功能不全或心绞痛等）", "label": 4, "label_text": "Disease", "id": "s2602"}
{"text": " 年龄≥18岁", "label": 3, "label_text": "Age", "id": "s2603"}
{"text": " （8）眼底筛查有眼病不适宜使用硫酸羟氯喹者。", "label": 5, "label_text": "Multiple", "id": "s2604"}
{"text": " 5自愿受试并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s2605"}
{"text": " 2、慢性、瘙痒性、以丘疹或结节为主要疹型的皮疹，持续时间＞1个月。", "label": 4, "label_text": "Disease", "id": "s2606"}
{"text": " ⑥ 血尿孕酮水平低于黄体期水平3.2ng/ml。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2607"}
{"text": "1、男性或女性，年龄介于18至80岁之间", "label": 5, "label_text": "Multiple", "id": "s2608"}
{"text": " 5、继发性头痛的患者；", "label": 4, "label_text": "Disease", "id": "s2609"}
{"text": " 4．临床诊断的复杂区域疼痛综合症；", "label": 11, "label_text": "Diagnostic", "id": "s2610"}
{"text": " 2、发病7天以内；", "label": 4, "label_text": "Disease", "id": "s2611"}
{"text": " （3）签署书面知情同意。", "label": 13, "label_text": "Consent", "id": "s2612"}
{"text": " 3、双侧或单侧输卵管积水（B超检查且未做处理）；", "label": 4, "label_text": "Disease", "id": "s2613"}
{"text": "患有其他严重干扰本病发展的疾病；", "label": 4, "label_text": "Disease", "id": "s2614"}
{"text": "①签订知情同意书时年龄在18岁到60岁之间；", "label": 5, "label_text": "Multiple", "id": "s2615"}
{"text": " 4)评估肾小球滤过率(eGFR)≥30ml/min（Scr-EPI公式）", "label": 12, "label_text": "Laboratory Examinations", "id": "s2616"}
{"text": "（1）影像学检查 HCC 肝脏肿瘤巨大(≥60%肝体积), 或门脉主干癌栓 (占据血管管径≥50%) , 或癌栓侵犯肠系膜静脉或下腔静脉。在参加该研究前肝移植、外科切除、TACE、射频/微波/化学消融、氩氦刀、超声刀、放疗等治疗；", "label": 5, "label_text": "Multiple", "id": "s2617"}
{"text": "1.经肠镜活检确诊为直肠癌的患者", "label": 11, "label_text": "Diagnostic", "id": "s2618"}
{"text": " ⑥接受EPO、其他益气类口服或静脉中成药治疗患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2619"}
{"text": " 2. 乳腺穿刺活检证实为Her-2阳性者及Luminal A型患者;", "label": 11, "label_text": "Diagnostic", "id": "s2620"}
{"text": " 9.血清HIV抗体阳性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2621"}
{"text": " 7.受试者能够及愿意进行血糖自我检测.", "label": 12, "label_text": "Laboratory Examinations", "id": "s2622"}
{"text": " 9）妊娠和准备妊娠的妇女，哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2623"}
{"text": " iii.在第I期给药前的14天内的任何时间服用过任何药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2624"}
{"text": "1.正在接受或3个月内接受放化疗、靶向治疗或生物治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2625"}
{"text": " （4）患有恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s2626"}
{"text": "1.呼吸睡眠暂停综合症患者", "label": 4, "label_text": "Disease", "id": "s2627"}
{"text": " ⑸四周内参加过癌症药物临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s2628"}
{"text": " 14)长期服用水杨酸药物，除了低剂量阿司匹林（100-300 mg/d）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2629"}
{"text": " 5.既往消化道溃疡病史，不能应用阿司匹林及氯吡格雷双重抗血小板聚集治疗者；", "label": 5, "label_text": "Multiple", "id": "s2630"}
{"text": "1.AA伴克隆性染色体异常；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2631"}
{"text": " 2.无自主行动能力的患者；", "label": 17, "label_text": "Capacity", "id": "s2632"}
{"text": " 8. 因免疫抑制疗法而加重的潜在的、慢性的或持续性的感染；", "label": 5, "label_text": "Multiple", "id": "s2633"}
{"text": " 2.有化脓性及慢性感染性伤口迁延不愈者；", "label": 4, "label_text": "Disease", "id": "s2634"}
{"text": " 6使用激酶类药物或抗自由基剂；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2635"}
{"text": " 2.进行根治性同步放化疗，毒副反应评估需流质饮食或洼田实验评估需管饲营养受试者；", "label": 5, "label_text": "Multiple", "id": "s2636"}
{"text": "1.年龄：18-70岁；", "label": 3, "label_text": "Age", "id": "s2637"}
{"text": " 8.ECOG评分3-4分。", "label": 9, "label_text": "Risk Assessment", "id": "s2638"}
{"text": " ②年龄18-65岁。", "label": 3, "label_text": "Age", "id": "s2639"}
{"text": " 3. 4周内接受过任何常规或研究性抗多发性骨髓瘤药物治疗（说明书注明用于抗多发性骨髓瘤治疗；沙利度胺维持治疗缩短至试验前2周内）或放疗（如果曾接受限制野放疗可以缩短时间至试验前2周内）；", "label": 5, "label_text": "Multiple", "id": "s2640"}
{"text": " 2.8  拒绝签署知情同意书;", "label": 13, "label_text": "Consent", "id": "s2641"}
{"text": " 3.健康状况：无心、肝、肾、消化道、神经系统、精神异常及代谢异常等病史、体格检查显示血压、心率、心电图、呼吸系统、肝、肾功能和血象正常或异常无临床意义；", "label": 32, "label_text": "Healthy", "id": "s2642"}
{"text": " 3.有使用他汀药物禁忌症", "label": 4, "label_text": "Disease", "id": "s2643"}
{"text": " 7、妇女试验前尿HCG检查结果阳性者；试验期间未采取有效避孕措施者；", "label": 5, "label_text": "Multiple", "id": "s2644"}
{"text": " 6）凝血障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2645"}
{"text": " 无法处理的近端动脉闭塞疾病", "label": 4, "label_text": "Disease", "id": "s2646"}
{"text": " 4、育龄期受试者（包括女性和男性病人的女伴）能采取有效的避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2647"}
{"text": " ②诊断为重型肝炎（含急性、亚急性及慢性重型肝炎）者；", "label": 4, "label_text": "Disease", "id": "s2648"}
{"text": " 2、符合中医证候(肝胃不和、胃阴不足、脾胃湿热和脾虚气滞证）诊断标准者", "label": 11, "label_text": "Diagnostic", "id": "s2649"}
{"text": " ⑦确诊或怀疑合并恶性肿瘤（含原发性肝癌）者；其中AFP≥20 ng/ml者须经CT等检查排除肝脏肿瘤；", "label": 5, "label_text": "Multiple", "id": "s2650"}
{"text": " 4.无言语沟通障碍，能理解并配合各项治疗措施", "label": 5, "label_text": "Multiple", "id": "s2651"}
{"text": " ③ TSH抑制目标在正常水平以下，属于亚临床甲亢者；", "label": 4, "label_text": "Disease", "id": "s2652"}
{"text": " ②年龄18-70周岁；", "label": 3, "label_text": "Age", "id": "s2653"}
{"text": "①受伤前患有糖尿病、消化道溃疡、胃炎、结肠炎、肠易激综合症、多发性硬化、其他免疫性疾病等；", "label": 4, "label_text": "Disease", "id": "s2654"}
{"text": "    c)Schirmer试验（表麻）≤5mm/5min", "label": 12, "label_text": "Laboratory Examinations", "id": "s2655"}
{"text": " ?已知对乳剂、阿片类药物过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s2656"}
{"text": " ④上肢及手有畸形者", "label": 33, "label_text": "Disabilities", "id": "s2657"}
{"text": " ②滥用药物或酗酒史", "label": 2, "label_text": "Addictive Behavior", "id": "s2658"}
{"text": "1、是本研究直属研究中心的人员或者是本研究直属研究中心人员的直系亲属。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s2659"}
{"text": " 12）怀孕或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2660"}
{"text": " ③无严重内脏器官（心、肝、肾等）的功能障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2661"}
{"text": "1. 视力 ≥20/40", "label": 12, "label_text": "Laboratory Examinations", "id": "s2662"}
{"text": " （4）年龄为18-75岁；", "label": 3, "label_text": "Age", "id": "s2663"}
{"text": "1. 符合椎-基底动脉供血不足诊断标准的患者；", "label": 11, "label_text": "Diagnostic", "id": "s2664"}
{"text": " 5）初次美妥昔单抗皮试阳性患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2665"}
{"text": " （4）对沙利度胺或泼尼松过敏者，曾有严重药物过敏史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2666"}
{"text": " f)妊娠期、哺乳期及6个月内计划怀孕者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2667"}
{"text": "1、符合腰椎间盘突出症的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2668"}
{"text": "1、病情程度属于COPD稳定期以及急性加重期极重度的患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s2669"}
{"text": " （7）正在参加其他临床药物试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2670"}
{"text": " （3）慢性阻塞性肺疾病急性加重期或肺心病或呼吸衰竭患者；", "label": 4, "label_text": "Disease", "id": "s2671"}
{"text": " （8）有神经系统及精神疾病史；", "label": 4, "label_text": "Disease", "id": "s2672"}
{"text": " 13)近3个月内参加其他药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2673"}
{"text": " 3). 不伴随化疗方案的患者，需在本试验随机化的前14天已结束放化疗；", "label": 5, "label_text": "Multiple", "id": "s2674"}
{"text": "（1）子宫病变（子宫肌瘤或腺肌瘤压迫宫腔线，ET前内膜≤8mm，宫腔粘连，监测中怀疑有内膜息肉，子宫及其他生殖器官严重畸形等）", "label": 5, "label_text": "Multiple", "id": "s2675"}
{"text": " 5，严重的慢性疾病，包括未控制的高血压，心绞痛或脑血管疾病", "label": 4, "label_text": "Disease", "id": "s2676"}
{"text": " 5.膝关节畸形内&lt;15°、外翻&lt;20°、屈曲挛缩&lt;15°，屈伸活动度至少90°", "label": 12, "label_text": "Laboratory Examinations", "id": "s2677"}
{"text": "1.符合西医股骨头缺血性坏死诊断标准及中医辩证属于气滞血瘀和肝肾不足者；", "label": 11, "label_text": "Diagnostic", "id": "s2678"}
{"text": " (5)试验开始前30天内酗酒或者试验前6个月内存在酒精或药物依赖者；", "label": 2, "label_text": "Addictive Behavior", "id": "s2679"}
{"text": " p)3个月内参加过其他药物试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2680"}
{"text": " 3.年龄≤70岁。", "label": 3, "label_text": "Age", "id": "s2681"}
{"text": " 5.合并代谢性疾病（糖尿病除外）;", "label": 4, "label_text": "Disease", "id": "s2682"}
{"text": " （3）肝切除术中伴切除胆囊、脾脏以外的其他脏器手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2683"}
{"text": " 6.有精神障碍或疾病、意识行为能力部分或完全受限，无自主决定能力者", "label": 4, "label_text": "Disease", "id": "s2684"}
{"text": " （2）心电图心肌缺血的新变化", "label": 1, "label_text": "Sign", "id": "s2685"}
{"text": "（1）以颈部疼痛不适、僵硬或颈椎活动受限为主诉；", "label": 28, "label_text": "Symptom", "id": "s2686"}
{"text": "（1）不符合功能性肠病的诊断标准者。", "label": 11, "label_text": "Diagnostic", "id": "s2687"}
{"text": "①年龄18～70岁；", "label": 3, "label_text": "Age", "id": "s2688"}
{"text": " 3.肿瘤直径＞8cm", "label": 24, "label_text": "Neoplasm Status", "id": "s2689"}
{"text": " 3)正在接受镇痛治疗，基础疼痛治疗阿片类药物为盐酸羟考酮缓释片，可联合其他非阿片类镇痛药物，长期规律服用≥1周；爆发痛可用即释吗啡、对乙酰氨基酚、氨酚曲马多、氨酚羟考酮等短效药物或肠外注射吗啡注射液、羟考酮注射液等。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2690"}
{"text": " 5.针道附近局部感染或肿瘤，存在感染播散至深部组织风险者。", "label": 4, "label_text": "Disease", "id": "s2691"}
{"text": " 6 中医辨证属气虚血瘀证、脾肾亏虚证者；", "label": 11, "label_text": "Diagnostic", "id": "s2692"}
{"text": " 3妊娠期或哺乳期女性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2693"}
{"text": " 3. 年龄18--60岁；", "label": 3, "label_text": "Age", "id": "s2694"}
{"text": " 15. 临床未发现（症状，体征，影像学，脑脊液）中枢神经系统白血病，淋巴瘤患者无中枢神经系统转移病灶。", "label": 4, "label_text": "Disease", "id": "s2695"}
{"text": " 5）3个月内接受无抽搐电休克治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s2696"}
{"text": " （9）病情未得到控制的糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s2697"}
{"text": " 8，      依从性良好，自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2698"}
{"text": " 5、重症肌无力患者；", "label": 4, "label_text": "Disease", "id": "s2699"}
{"text": " 3.机械通气时间≥3天。", "label": 38, "label_text": "Nursing", "id": "s2700"}
{"text": "1）年龄为18-50岁，性别不限；右利手；初中以上文化水平；", "label": 5, "label_text": "Multiple", "id": "s2701"}
{"text": " 4.HIV阴性", "label": 12, "label_text": "Laboratory Examinations", "id": "s2702"}
{"text": "  [3] 卵巢可疑转移者；", "label": 4, "label_text": "Disease", "id": "s2703"}
{"text": " 4、 ASA分级 I-II级；", "label": 9, "label_text": "Risk Assessment", "id": "s2704"}
{"text": " 13)随访期间失访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2705"}
{"text": " 2. 年龄在18-80岁之间；", "label": 3, "label_text": "Age", "id": "s2706"}
{"text": " 1)血液学：中性粒细胞绝对值≥1.5×109/L，血小板计数≥75×109/L，血红蛋白≥90g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2707"}
{"text": " 2）预期生存期&lt;3个月者；", "label": 23, "label_text": "Life Expectancy", "id": "s2708"}
{"text": " 4.孕妇及儿童；", "label": 26, "label_text": "Encounter", "id": "s2709"}
{"text": " 2.年龄≥65周岁，男女均可，BMI为18～24kg/m2", "label": 5, "label_text": "Multiple", "id": "s2710"}
{"text": " 2 拟行调强放疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2711"}
{"text": "① 年龄≥18岁，≤70岁；", "label": 3, "label_text": "Age", "id": "s2712"}
{"text": " 不同意在试验期避孕的男性及女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2713"}
{"text": " b.具有中度/重度肾损伤或者终末期肾病的患者（eGFR&lt; 60 mL/min/1.73 m2）；", "label": 4, "label_text": "Disease", "id": "s2714"}
{"text": "（1）临床诊断为AK（OLSEN分级：Ⅰ、Ⅱ和Ⅲ级），年龄&gt;18岁；", "label": 5, "label_text": "Multiple", "id": "s2715"}
{"text": " ?粒细胞计数≥1.5×109/L，血小板计数&gt;80×109/L。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2716"}
{"text": " 5.研究开始前4周内参加过其他药物临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2717"}
{"text": " (3)原发性痴呆，早期表现为记忆损害，渐进加重，同时伴其他认知功能损害 如失语、失用、失认，且缺乏相关的脑影像学检查的局灶性损害；", "label": 5, "label_text": "Multiple", "id": "s2718"}
{"text": " （4）已完善相关辅助检查，如血常规、肝肾功能、止凝血等；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2719"}
{"text": "1.明确诊断为腹股沟疝的患者；", "label": 11, "label_text": "Diagnostic", "id": "s2720"}
{"text": "①年龄&gt;45岁，签署知情同意者。", "label": 5, "label_text": "Multiple", "id": "s2721"}
{"text": " 3. 伴有其他合并疾病，研究者认为可能影响手术过程或麻醉效果；", "label": 5, "label_text": "Multiple", "id": "s2722"}
{"text": " 3.ECOG体力状态评分0-2或KPS功能状态评分≥70分；", "label": 9, "label_text": "Risk Assessment", "id": "s2723"}
{"text": " 3.Holter显示24小时室早负荷&gt;5%/非持续性室速不愿接受药物或导管消融治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s2724"}
{"text": " ?合并以下疾病或状况：新近诊断有中枢神经系统转移的患者（既往发生过中枢神经系统转移，经治疗后中枢神经系统病灶影像学不可见者不在此列），严重或不能控制的全身性疾病或任何不稳定的系统性疾病（包括但不限于活动性感染、三级高血压、不稳定心绞痛、充血性心力衰竭、Ⅲ或Ⅳ级心脏病、严重的心律失常、肝肾功能不全或代谢性疾病），既往有明确的神经或精神障碍史等。", "label": 5, "label_text": "Multiple", "id": "s2725"}
{"text": " 5．术前已行γ-刀、放射治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2726"}
{"text": " （5） 乙型肝炎表面抗原（HBsAg）、丙型肝炎抗体（HCV-Ab）、梅毒抗体（TP-Ab）或艾滋病病毒抗体（HIV-Ab）检查结果呈阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2727"}
{"text": " （7）经颅多普勒超声，颈动脉血管超声，头MRA或CTA检查，发现颅内外颈动脉或MCA、椎基底动脉存在中度以上狭窄（50%以上）。", "label": 11, "label_text": "Diagnostic", "id": "s2728"}
{"text": " c)患者无自主行为能力且无法找到法定代理人签署签署知情同意书患者", "label": 5, "label_text": "Multiple", "id": "s2729"}
{"text": "1.诊断为重症急性胰腺炎(Ranson评分≥3；APACHE -Ⅱ评分 ≥8；CT分级为 D、 E)；", "label": 5, "label_text": "Multiple", "id": "s2730"}
{"text": " 6. 轻、中度吞咽困难", "label": 28, "label_text": "Symptom", "id": "s2731"}
{"text": "1）已确诊有消化道疾病比如溃疡、出血等，以及胃泌素瘤患者。", "label": 4, "label_text": "Disease", "id": "s2732"}
{"text": " （5）筛选前3个月内参加过或正在参加其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s2733"}
{"text": " 3. 尿道括约肌功能良好；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2734"}
{"text": " 5）既往身体健康，对生物制剂无严重过敏反应者；", "label": 5, "label_text": "Multiple", "id": "s2735"}
{"text": " 4.子宫全切的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2736"}
{"text": " 2.年龄介于18-75岁之间的男性或者女性成年人；", "label": 5, "label_text": "Multiple", "id": "s2737"}
{"text": " 6.要求使用免疫抑制剂的同种异体器官移植史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2738"}
{"text": " （4）盆腔手术史或有严重全身疾病如心、肺、肾等的患者；", "label": 5, "label_text": "Multiple", "id": "s2739"}
{"text": " 3．颈源性疼痛；", "label": 28, "label_text": "Symptom", "id": "s2740"}
{"text": " （5）孕、产妇，严重的肝肾功能损害或装有心脏起搏器；", "label": 5, "label_text": "Multiple", "id": "s2741"}
{"text": " (4) 预计生存期≥3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s2742"}
{"text": " 6)无血管内介入治疗禁忌症；", "label": 4, "label_text": "Disease", "id": "s2743"}
{"text": " ②有利多卡因胶浆及西甲硅油乳剂禁忌证（见药物说明书）。", "label": 4, "label_text": "Disease", "id": "s2744"}
{"text": " 4、受试者知情，自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2745"}
{"text": " (3) 通过超声、CT 等影像学方法或者临床高度怀疑有肝转移者；", "label": 11, "label_text": "Diagnostic", "id": "s2746"}
{"text": " 6）中医辩证上述主症少于两个、兼证少于两个者；", "label": 11, "label_text": "Diagnostic", "id": "s2747"}
{"text": " D.糖尿病患者血糖控制不佳（空腹血糖（FBG）＞10mmol/L)；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2748"}
{"text": " 12. 怀孕或哺乳期妇女；有生育能力的患者不愿或无法采取有效的避孕措施者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2749"}
{"text": " (6)皮肤点刺试验阳性和/或血清特异性IgE检测阳性", "label": 12, "label_text": "Laboratory Examinations", "id": "s2750"}
{"text": " 3、月经周期第三天FSH水平≤12IU/L；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2751"}
{"text": " 6.第一次试验药物给药前1周左右内尿液或血清妊娠试验结果为阴性（针对育龄期妇女），且患者愿意在治疗及结束用药后至少6个月内采取有效的避孕措施", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2752"}
{"text": " 6. 患者的预期寿命小于12个月。", "label": 23, "label_text": "Life Expectancy", "id": "s2753"}
{"text": " 4. 术前ASA评级1-3级，入手术室时无危及生命的紧急情况", "label": 9, "label_text": "Risk Assessment", "id": "s2754"}
{"text": " 8)研究者认为不适合入组者。", "label": 21, "label_text": "Researcher Decision", "id": "s2755"}
{"text": " 5）伴有皮肤缺损；", "label": 4, "label_text": "Disease", "id": "s2756"}
{"text": " ③志愿受试并签署《盐酸氨基葡萄糖片联合透明质酸钠治疗颞下颌关节紊乱病患者知情同意书》", "label": 13, "label_text": "Consent", "id": "s2757"}
{"text": " 14.同时采用其他试验药物或受试前一个月参加过其他药物临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2758"}
{"text": " 5). 既往曾患胰腺炎者。", "label": 4, "label_text": "Disease", "id": "s2759"}
{"text": " （9）妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2760"}
{"text": "  —血清总胆红素≤1.5mg/dL(即≤25.65μmol/L)。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2761"}
{"text": " （4）有精神病史无法合作的患者", "label": 4, "label_text": "Disease", "id": "s2762"}
{"text": " （7）患者知情同意，愿意接受治疗，并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s2763"}
{"text": "1 严重心血管疾病，既往心梗，心律失常", "label": 4, "label_text": "Disease", "id": "s2764"}
{"text": " （3）不同意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s2765"}
{"text": " （2）继发性AML患者（包含继发MDS的AML）", "label": 4, "label_text": "Disease", "id": "s2766"}
{"text": " 12. 需要药物治疗的癫痫、痴呆及其他精神状况异常不能理解或遵从研究方案者。", "label": 5, "label_text": "Multiple", "id": "s2767"}
{"text": " 4)免疫缺陷疾病，或近3个月内使用免疫抑制剂或糖皮质激素者；", "label": 5, "label_text": "Multiple", "id": "s2768"}
{"text": "1）有以下疾病史：甲状腺疾病史，肾上腺疾病史，性传播疾病史，精神心理障碍。", "label": 4, "label_text": "Disease", "id": "s2769"}
{"text": "1. 患有高血压且经降压药物治疗无法降至正常范围者（收缩压&gt;140 mmHg，舒张压&gt;90 mmHg），患有Ｉ级以上冠心病、II级心律失常（包括QTc间期延长＞470 ms）及II级心功能不全；", "label": 5, "label_text": "Multiple", "id": "s2770"}
{"text": "1. 已证实对阿帕替尼和/或其辅料过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2771"}
{"text": " 8.发病后使用过神经保护剂者（如依达拉奉、神经节苷酯、马来酸桂哌齐特等）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2772"}
{"text": " 5)准备妊娠者、孕妇及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2773"}
{"text": " （15）术中出血超过10ml/kg", "label": 1, "label_text": "Sign", "id": "s2774"}
{"text": " a）基于临床证据和/或病原学阳性结果的怀疑或证实的感染；", "label": 11, "label_text": "Diagnostic", "id": "s2775"}
{"text": " 3、患者同意参加本研究，并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s2776"}
{"text": " 同意参与本研究并且能坚持随访", "label": 5, "label_text": "Multiple", "id": "s2777"}
{"text": " （4）病史资料不全者；", "label": 22, "label_text": "Data Accessible", "id": "s2778"}
{"text": " (3)正常身高和体重；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2779"}
{"text": " 2. 白细胞数量低于临床参考值下限，以及患有其他血液系统疾病者；", "label": 5, "label_text": "Multiple", "id": "s2780"}
{"text": " （2）肺功能检测FEV1%&lt;30%；", "label": 5, "label_text": "Multiple", "id": "s2781"}
{"text": " (5)患有严重的心、肝、肾等重要脏器原发疾病及血液系统疾病者；", "label": 4, "label_text": "Disease", "id": "s2782"}
{"text": " ②支气管哮喘或慢性阻塞性肺疾病；近两周有上呼吸道感染及咳嗽", "label": 4, "label_text": "Disease", "id": "s2783"}
{"text": " （4） 符合中医痰热腑实证辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s2784"}
{"text": "1）择期行POEM手术的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2785"}
{"text": " 3.HIV病毒感染；", "label": 4, "label_text": "Disease", "id": "s2786"}
{"text": " 7.孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2787"}
{"text": " ⑤严重有精神疾病或精神疾病家族史；", "label": 4, "label_text": "Disease", "id": "s2788"}
{"text": " ②根据1987年美国风湿学会(ARA)类风湿关节炎诊断指导指南确诊的类风湿关节炎患者；", "label": 11, "label_text": "Diagnostic", "id": "s2789"}
{"text": " 5.先天性免疫缺陷病、器官移植史、第二肿瘤。", "label": 5, "label_text": "Multiple", "id": "s2790"}
{"text": " (2）年龄：3-70岁", "label": 3, "label_text": "Age", "id": "s2791"}
{"text": " 6.已知对美能过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2792"}
{"text": " 2.2.7四周内曾采用抗变态反应药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2793"}
{"text": " 15.有合并其他感染或者疾病需要长期服用口服抗生素经过/不经过肠道代谢的情况；", "label": 5, "label_text": "Multiple", "id": "s2794"}
{"text": " （4）入组前 48 小时内至少有一次心绞痛发作者；", "label": 4, "label_text": "Disease", "id": "s2795"}
{"text": " (2)MAS分级&lt;3级；", "label": 9, "label_text": "Risk Assessment", "id": "s2796"}
{"text": " 6.重度贫血患者（血红蛋白低于6克/每分升）；", "label": 5, "label_text": "Multiple", "id": "s2797"}
{"text": "1 临床资料不完整", "label": 22, "label_text": "Data Accessible", "id": "s2798"}
{"text": "（1）急性肝衰竭、亚急性肝衰竭、慢性肝衰竭；", "label": 4, "label_text": "Disease", "id": "s2799"}
{"text": "1、凝血功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2800"}
{"text": "(1)有心理疾病史或精神疾病史或患精神疾病者", "label": 4, "label_text": "Disease", "id": "s2801"}
{"text": " 4.不能理解NRS患者。", "label": 17, "label_text": "Capacity", "id": "s2802"}
{"text": " 2. 根据Beagley-Gibson手部皮肤老化分级标准评定，手背皮肤老化级别为三级以上者。", "label": 9, "label_text": "Risk Assessment", "id": "s2803"}
{"text": " 6.重度心肺功能不全者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2804"}
{"text": " 12.哺乳期或孕期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2805"}
{"text": " ② 2型糖尿病前期及其患者，诊断符合《中国2型糖尿病防治指南（2013版）》（表1），项目组建议优先纳入最近一年内接受过糖尿病筛查，确诊结果为糖尿病的居民和糖尿病前期居民。", "label": 11, "label_text": "Diagnostic", "id": "s2806"}
{"text": "⑴符合腹泻型IBS诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2807"}
{"text": " （5) 症状持续时间超过2-3个月", "label": 28, "label_text": "Symptom", "id": "s2808"}
{"text": "1. 年龄≤16岁", "label": 3, "label_text": "Age", "id": "s2809"}
{"text": " 4.Karnofsky评分低于60分；", "label": 9, "label_text": "Risk Assessment", "id": "s2810"}
{"text": "（1）年龄在18周岁以上，65周岁以下；", "label": 3, "label_text": "Age", "id": "s2811"}
{"text": "①符合COPD诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2812"}
{"text": " 2、既往有陈旧心梗病史或经冠脉造影证实至少有一支冠脉狭窄≥50%；", "label": 5, "label_text": "Multiple", "id": "s2813"}
{"text": " 7.在促排卵过程中出现卵巢过度刺激高风险的患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2814"}
{"text": "1. 经影像学检查确诊为股骨转子下长段粉碎性骨折，且符合《实用骨科学》中相关诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s2815"}
{"text": "1.行择期全胸腔镜下微创射频消融术的孤立性房颤患者", "label": 5, "label_text": "Multiple", "id": "s2816"}
{"text": "a、有胃食管反流病相关症状，如：烧心、泛酸、胸骨后灼痛、平卧或睡眠时呛咳、咽喉不适等；", "label": 28, "label_text": "Symptom", "id": "s2817"}
{"text": "(1)符合HP根除指征的HP阳性NUD患者；", "label": 11, "label_text": "Diagnostic", "id": "s2818"}
{"text": "    a.经标准化疗2个疗程未获得CR", "label": 0, "label_text": "Therapy or Surgery", "id": "s2819"}
{"text": " （4）HAD情绪测定,焦虑或抑郁评分≥8分;", "label": 9, "label_text": "Risk Assessment", "id": "s2820"}
{"text": " 4.研究者预计依从性差或者不能配合以及不宜纳入本试验者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s2821"}
{"text": " ⑤正在应用糖皮质激素或抗炎药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2822"}
{"text": " （3）筛选时服用氯沙坦钾片的剂量＞50mg/日者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2823"}
{"text": " 2.ASA分级Ⅱ～Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s2824"}
{"text": " 合并青光眼、葡萄膜炎、年龄相关性黄斑变性以及视神经病变等严重眼部疾病患者；", "label": 4, "label_text": "Disease", "id": "s2825"}
{"text": " 4) 过去5年内用屋尘螨提取物或其他过敏原进行过脱敏治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2826"}
{"text": " 5.文化程度小学以上；", "label": 41, "label_text": "Education", "id": "s2827"}
{"text": "（1）BMI&lt;18kg/m2 或BMI&gt;31kg/m2", "label": 9, "label_text": "Risk Assessment", "id": "s2828"}
{"text": " 4) 对本制剂成分可能过敏的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s2829"}
{"text": " 3、卵巢储备功能减退，FSH&gt;12U/L或AFC&lt;8或AMH&lt;1.1ng/ml", "label": 5, "label_text": "Multiple", "id": "s2830"}
{"text": " 2、能够且愿意签定知情同意书", "label": 13, "label_text": "Consent", "id": "s2831"}
{"text": " 4.同期行双侧膝关节置换术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2832"}
{"text": " 3.孕妇肝功能、肌酐、尿素氮、HIV/HCV、心电图检查正常；", "label": 5, "label_text": "Multiple", "id": "s2833"}
{"text": " 5、签署知情同意书", "label": 13, "label_text": "Consent", "id": "s2834"}
{"text": " 5）心功能NYHAI-II级，且EF大于40%以上；", "label": 9, "label_text": "Risk Assessment", "id": "s2835"}
{"text": " 4.急性胃肠功能障碍自行好转者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2836"}
{"text": " ②年龄在40-80岁之间；", "label": 3, "label_text": "Age", "id": "s2837"}
{"text": " ①引起脑性瘫痪(简称脑瘫)的脑损伤为非进行性；", "label": 4, "label_text": "Disease", "id": "s2838"}
{"text": " 13.有预计生存时间&lt;28天的基础疾病或终末期状态；", "label": 5, "label_text": "Multiple", "id": "s2839"}
{"text": " 11.四周内存在感染，存在应激状态的患者。", "label": 4, "label_text": "Disease", "id": "s2840"}
{"text": " 5.过去3月未使用任何精神药物或接受任何心理或行为治疗，未使用过激素治疗，选择性雌激素受体调节剂，或者芳香化酶抑制剂、大豆提取物或草药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2841"}
{"text": "(1)年龄1～5岁；", "label": 3, "label_text": "Age", "id": "s2842"}
{"text": " 4、精神不正常者", "label": 4, "label_text": "Disease", "id": "s2843"}
{"text": " 5)习惯性流产史；", "label": 4, "label_text": "Disease", "id": "s2844"}
{"text": " 3.KPS评分&gt;60分；", "label": 9, "label_text": "Risk Assessment", "id": "s2845"}
{"text": " （9）性激素检查提示严重高泌乳素血症、性腺功能障碍；", "label": 4, "label_text": "Disease", "id": "s2846"}
{"text": "①严重心肺疾病者；", "label": 4, "label_text": "Disease", "id": "s2847"}
{"text": " 8. 曾接受过任何基因治疗产品；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2848"}
{"text": " ②过敏体质及对多种药物过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s2849"}
{"text": " ⑵有明确使用美罗培南的用药指征；", "label": 5, "label_text": "Multiple", "id": "s2850"}
{"text": " 7.服用镇痛药，抗抑郁药，镇咳药者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2851"}
{"text": "1.急性缺血性脑卒中首次发病，或过去发病未留有神经功能缺损等后遗症者；", "label": 4, "label_text": "Disease", "id": "s2852"}
{"text": " 4.年龄在18-60岁之间；", "label": 3, "label_text": "Age", "id": "s2853"}
{"text": "主要排除标准： 符合以下任何一项标准的患者将从本试验中排除： 1.合并严重且不可控制的感染；", "label": 4, "label_text": "Disease", "id": "s2854"}
{"text": " 10)既往使用试验用药物（正清风痛宁、甲氨蝶呤）有不良反应者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2855"}
{"text": " 13)预期不能完成随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2856"}
{"text": "（1）入选年龄： 18-70 周岁；", "label": 3, "label_text": "Age", "id": "s2857"}
{"text": "①符合非特异性下腰痛诊断标准的患者。", "label": 11, "label_text": "Diagnostic", "id": "s2858"}
{"text": " 5.合并血液系统疾病；", "label": 4, "label_text": "Disease", "id": "s2859"}
{"text": " （3）血清学实验检查(ANF,抗RO抗体，抗LA抗体)阴性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2860"}
{"text": " 2.拟于结肠镜下切除腺瘤的病人", "label": 0, "label_text": "Therapy or Surgery", "id": "s2861"}
{"text": "1.非石蜡包埋组织切片样本；", "label": 29, "label_text": "Receptor Status", "id": "s2862"}
{"text": " 9. 研究期间内计划进行重要的择期手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2863"}
{"text": " 11、其他研究者认为不适合入组的情况", "label": 21, "label_text": "Researcher Decision", "id": "s2864"}
{"text": " ①因消化道活动性出血等原因无法在入监护室1周内实施肠内营养者。", "label": 5, "label_text": "Multiple", "id": "s2865"}
{"text": " 2.符合DSM-IV“重型抑郁障碍”诊断标准，55岁以后有过至少一次抑郁发作；", "label": 5, "label_text": "Multiple", "id": "s2866"}
{"text": " 4.女性受试者血妊娠试验阴性者；在整个临床试验期间及给药后1个月内无妊娠计划，并同意在试验期间以及给药后的1个月内，采取医学接受的可靠避孕方法。医学接受的可靠避孕方法指输卵管结扎术、子宫切除术、禁欲以及在使用宫内避孕器的情况下同时使用避孕套和/或阴道隔膜等避孕工具；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2867"}
{"text": " 2.合并有心脑血管系统、神经系统、免疫系统等重大系统性疾病，或高血压、糖尿病等慢性疾病控制不良者；", "label": 4, "label_text": "Disease", "id": "s2868"}
{"text": " ②符合血液高凝状态标准且Khorana评分中低危（0-2分），或符合血液高凝状态标准且Khorana评分高危（≥3分），但存在抗凝治疗禁忌的患者。", "label": 5, "label_text": "Multiple", "id": "s2869"}
{"text": " 4、严重的焦虑抑郁、治疗处皮肤破损或体表触觉异常的患者。", "label": 4, "label_text": "Disease", "id": "s2870"}
{"text": " 4. 术中中转开胸手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2871"}
{"text": " 6. 入选研究前28天内有消化道穿孔病史者；", "label": 4, "label_text": "Disease", "id": "s2872"}
{"text": " （6）恶性肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s2873"}
{"text": " 4、人类免疫缺陷病毒（HIV）阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2874"}
{"text": " 7.当前正在全身性使用类固醇药物，近期或者目前使用吸入性类固醇者不排除。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2875"}
{"text": "（1）1型糖尿病及其他特殊类型糖尿病；", "label": 4, "label_text": "Disease", "id": "s2876"}
{"text": "1患者签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2877"}
{"text": "（1）患髋部恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s2878"}
{"text": " （4）中风；", "label": 4, "label_text": "Disease", "id": "s2879"}
{"text": " 9.经研究者认定的不能按时完成研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s2880"}
{"text": "①肌电图检查符合腕管综合症", "label": 11, "label_text": "Diagnostic", "id": "s2881"}
{"text": " ②术中因大出血等突发情况更改麻醉方式；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2882"}
{"text": " 2)对试验药品或者其辅料有过敏史，过敏体质（多种药物及食物过敏）。", "label": 7, "label_text": "Allergy Intolerance", "id": "s2883"}
{"text": " 4.有其他脏器恶性肿瘤者；", "label": 4, "label_text": "Disease", "id": "s2884"}
{"text": " 3）如果在一个周期内受试者的胚胎没有达到上述要求，受试者也可以重新进入周期，累积胚胎数达到上述标准。", "label": 5, "label_text": "Multiple", "id": "s2885"}
{"text": " c. 无功能型腺瘤；", "label": 4, "label_text": "Disease", "id": "s2886"}
{"text": " 2.有颈部手术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2887"}
{"text": " 9.入组前的6个月内出现过腹部瘘管、胃肠道穿孔或腹腔脓肿；", "label": 4, "label_text": "Disease", "id": "s2888"}
{"text": "1. 年龄在18~75岁之间（包括18岁和75岁），性别不限；", "label": 5, "label_text": "Multiple", "id": "s2889"}
{"text": " 1.2 住院期间发生的“急性肾损伤/急性肾损害/急性肾衰竭/急性肾功能不全”（院内AKI）", "label": 5, "label_text": "Multiple", "id": "s2890"}
{"text": " 6.3个月内服用过影响骨代谢药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2891"}
{"text": " 7.有药物依赖史、滥用药物史、酒精中毒史；", "label": 2, "label_text": "Addictive Behavior", "id": "s2892"}
{"text": " （13）酒精呼气试验阳性（≥5mg/100ml）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2893"}
{"text": " 心跳骤停到开始基础生命支持时间不超过1分钟；", "label": 23, "label_text": "Life Expectancy", "id": "s2894"}
{"text": " 2.接受并签署知情同意书者.", "label": 13, "label_text": "Consent", "id": "s2895"}
{"text": " 6.肌酐清除率&lt;30ml/min或既往严重肾脏疾病；", "label": 5, "label_text": "Multiple", "id": "s2896"}
{"text": " （4）超声心动图：弥漫性左室壁增厚（舒张末期室壁厚度≥12mm）和右室游离壁增厚（舒张末期室壁厚度≥7mm），左室心肌呈现毛玻璃状背景和颗粒状回声增强、双房扩大、左室射血分数（LVEF）&lt; 50% 并呈进行性减低，E/A比值&gt; 2或E/e’比值＞15、心包积液。", "label": 5, "label_text": "Multiple", "id": "s2897"}
{"text": " (10)研究者认为不适合参加试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s2898"}
{"text": "1 受试者因任何原因在造影前服用过锂或相关制剂；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2899"}
{"text": " （5）已知对该类药物或试验用药中某味中药过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s2900"}
{"text": " ② 家族遗传性疾病史；", "label": 4, "label_text": "Disease", "id": "s2901"}
{"text": " 2）年龄18-40岁", "label": 3, "label_text": "Age", "id": "s2902"}
{"text": " 7. 依从性差或无法进行正常随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2903"}
{"text": " ⑶目标膝关节近三个月内关节腔注射糖皮质激素，或近2周内关节腔注射透明质酸钠，或近2周内接受针刺或艾灸治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2904"}
{"text": "1、满10周岁，不满60周岁的受试者。", "label": 3, "label_text": "Age", "id": "s2905"}
{"text": " 3）鼻腔有器质性病变或行鼻腔手术者；", "label": 5, "label_text": "Multiple", "id": "s2906"}
{"text": " f.家长／监护人能够阅读和理解普通话并与受试者一同签署知情同意书；", "label": 5, "label_text": "Multiple", "id": "s2907"}
{"text": " 7.严重肾功能不全，血清肌酐＞265umol/L者；", "label": 5, "label_text": "Multiple", "id": "s2908"}
{"text": " （4）性别：男女均可；", "label": 35, "label_text": "Gender", "id": "s2909"}
{"text": " ④无远处脏器转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s2910"}
{"text": " 12)3个月内再次手术者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2911"}
{"text": " 2. 术中需要插双腔气管插管实施单肺通气", "label": 38, "label_text": "Nursing", "id": "s2912"}
{"text": "①年龄大于65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s2913"}
{"text": " 4.医生认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s2914"}
{"text": " 7.患有精神疾患；", "label": 4, "label_text": "Disease", "id": "s2915"}
{"text": " 5. 过去3月内参加过其它临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s2916"}
{"text": " （6）BMI 18-25kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s2917"}
{"text": " 2、血糖、血压控制不佳；", "label": 1, "label_text": "Sign", "id": "s2918"}
{"text": " 4.提供愿意参加研究、顺从随访试验及评估程序的知情同意书；", "label": 13, "label_text": "Consent", "id": "s2919"}
{"text": " 4.知识水平和依从性均好的患者 (A↑D↑)", "label": 8, "label_text": "Compliance with Protocol", "id": "s2920"}
{"text": " 5）所有被试者均为右利手；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s2921"}
{"text": " c)患儿有严重胃肠道疾病", "label": 4, "label_text": "Disease", "id": "s2922"}
{"text": " 5、20≤BMI≤25", "label": 9, "label_text": "Risk Assessment", "id": "s2923"}
{"text": " 2）X线显示膝关节内侧间隙退行性变", "label": 5, "label_text": "Multiple", "id": "s2924"}
{"text": " 2.既往颅内出血、颅内肿瘤、蛛网膜下腔出血、动静脉畸形", "label": 4, "label_text": "Disease", "id": "s2925"}
{"text": " 3、妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2926"}
{"text": " 7）误吸风险高；", "label": 9, "label_text": "Risk Assessment", "id": "s2927"}
{"text": " (9)妊娠或准备妊娠、哺乳期的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2928"}
{"text": " 2.严重影响生活的男性手汗症患者；", "label": 5, "label_text": "Multiple", "id": "s2929"}
{"text": " 10.存在任何重度和/或未能控制的疾病；", "label": 4, "label_text": "Disease", "id": "s2930"}
{"text": " 4)严重的骨髓抑制", "label": 4, "label_text": "Disease", "id": "s2931"}
{"text": " （4）自愿参加，患儿父母或监护人签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s2932"}
{"text": " 4）胸上段食管鳞管： 病灶上缘位于食管入口至奇静脉弓下缘之间水平。", "label": 4, "label_text": "Disease", "id": "s2933"}
{"text": " 2.合并严重心、肝、肾、脑血管疾病。", "label": 4, "label_text": "Disease", "id": "s2934"}
{"text": " （3）过去1月几乎每天都有中等或明显的膝关节疼痛；", "label": 28, "label_text": "Symptom", "id": "s2935"}
{"text": " 7.ECOG评分0~1分，且预计生存期≥3个月；", "label": 5, "label_text": "Multiple", "id": "s2936"}
{"text": " 2.握力下降（男性&lt;26kg，女性&lt;18kg）或 步速下降（行走4m步速&lt;1.0m/s）或半年内非意愿性体重下降&gt;5%或3kg", "label": 12, "label_text": "Laboratory Examinations", "id": "s2937"}
{"text": " ④患者有酗酒或麻醉药物滥用、吸毒史，或具有精神病史（如精神分裂症、强迫症、抑郁症）、对抗性格、不良动机、多疑或其他情感或智力问题等可能影响参与此研究的知情有效性的情况；", "label": 5, "label_text": "Multiple", "id": "s2938"}
{"text": " （5）肥厚梗阻型心肌病、中重度主动脉瓣狭窄或关闭不全；", "label": 4, "label_text": "Disease", "id": "s2939"}
{"text": " 2.存在明显认知功能障碍；", "label": 4, "label_text": "Disease", "id": "s2940"}
{"text": " ⑧近一个月未服用抗菌药物、胃肠动力药及微生态调节剂等影响肠道菌群的药物，且无腹痛、便秘及腹泻等胃肠道症状。", "label": 5, "label_text": "Multiple", "id": "s2941"}
{"text": " 5)不能耐受手术或麻醉者", "label": 7, "label_text": "Allergy Intolerance", "id": "s2942"}
{"text": "1.反复咳嗽、咳痰；", "label": 28, "label_text": "Symptom", "id": "s2943"}
{"text": " 3.不耐受治疗的.", "label": 7, "label_text": "Allergy Intolerance", "id": "s2944"}
{"text": " 2、右室机械瓣患者，心脏移植的患者或等待心脏移植的患者，严重心脏瓣膜疾病者拟行外科手术者；", "label": 5, "label_text": "Multiple", "id": "s2945"}
{"text": "（1）年龄18-75岁；", "label": 3, "label_text": "Age", "id": "s2946"}
{"text": "1.术前24小时内有恶心或呕吐者", "label": 28, "label_text": "Symptom", "id": "s2947"}
{"text": " (5)本人或其监护人同意参加本研究并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s2948"}
{"text": " ②30岁以下或55岁以上的患者、妊娠和哺乳期妇女、肿瘤患者和腰椎结核合并严重感染者、有严重腰椎创伤史和腰椎手术史者；", "label": 5, "label_text": "Multiple", "id": "s2949"}
{"text": " ③血清25(OH)D水平低于20ng/ml。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2950"}
{"text": "年龄在25岁以下或50岁以上者，绝经患者；", "label": 5, "label_text": "Multiple", "id": "s2951"}
{"text": "（1）患有高度近视（近视度数大于600度以上）或其它眼部疾病者；", "label": 4, "label_text": "Disease", "id": "s2952"}
{"text": " 4）A2DS2评分5分，即为卒中相关性肺炎高危人群，见附件1。", "label": 5, "label_text": "Multiple", "id": "s2953"}
{"text": " ⑥安置心脏起搏器的患者；", "label": 34, "label_text": "Device", "id": "s2954"}
{"text": " e.符合中医证候诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s2955"}
{"text": " 5.严重自杀企图者（HAMD-17量表第3项“自杀”≥3分）；", "label": 9, "label_text": "Risk Assessment", "id": "s2956"}
{"text": "1)受试者自愿加入本研究，签署知情同意书，依从性好，配合随访。", "label": 5, "label_text": "Multiple", "id": "s2957"}
{"text": " (2) 患有特发性高钙血症者；", "label": 4, "label_text": "Disease", "id": "s2958"}
{"text": " ⑤术中出血&gt;1000ml：防止应激性溃疡问题。", "label": 5, "label_text": "Multiple", "id": "s2959"}
{"text": " 2. 连续三次测得的坐位收缩压相差大于20mmHg 、舒张压相差大于10mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s2960"}
{"text": " ①伴有临床动脉硬化性心血管疾病（ASCVD）的患者；", "label": 4, "label_text": "Disease", "id": "s2961"}
{"text": "（1）ASA Ⅰ-Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s2962"}
{"text": " 10、无法坚持到院检查及随访，或随访期间欲行其他治疗。", "label": 8, "label_text": "Compliance with Protocol", "id": "s2963"}
{"text": " （7）术前心功能不全&gt;III级和/或心绞痛&gt;III级和/或LVEF&lt;35%；", "label": 5, "label_text": "Multiple", "id": "s2964"}
{"text": "1. 近期已计划首次、再次做导管消融手术者；近三个月接受导管消融手术者；已接受左心耳封堵手术或近期准备做左心耳封堵手术者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2965"}
{"text": " 2.伴有严重心血管疾患，或病情极度危重，脑疝，预期难以完成实验。", "label": 4, "label_text": "Disease", "id": "s2966"}
{"text": " （3） 既往有食管胃静脉曲张出血病史（黑便、呕血等），且从未接受过内镜治疗；", "label": 5, "label_text": "Multiple", "id": "s2967"}
{"text": " 10）怀孕或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2968"}
{"text": " 2. 临床上有未经控制的活动性感染者；", "label": 4, "label_text": "Disease", "id": "s2969"}
{"text": "（1）患者及其法定代理人自愿参加研究，且签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s2970"}
{"text": " 5.取样及保存不当样本。", "label": 29, "label_text": "Receptor Status", "id": "s2971"}
{"text": " 5.妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s2972"}
{"text": " *术后病理学确诊为肺恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s2973"}
{"text": "1.存在影响脂肪细胞代谢的其他疾病，如口服降糖药或降脂药患者；", "label": 5, "label_text": "Multiple", "id": "s2974"}
{"text": " 3.肝功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2975"}
{"text": " 8.治疗前受试者全血样本CTC检测值大于8.5CU/3mL。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2976"}
{"text": "1.既往有盆腔卵巢手术化疗放疗史", "label": 0, "label_text": "Therapy or Surgery", "id": "s2977"}
{"text": "1.术前确诊食管癌且拟行手术治疗的患者。所有患者术前均进行胃镜检查，病理确诊为食管鳞癌，且病理TNM分期不超过T3a期。", "label": 5, "label_text": "Multiple", "id": "s2978"}
{"text": " 2.无法依从试验方案；", "label": 8, "label_text": "Compliance with Protocol", "id": "s2979"}
{"text": " 4.N末端前脑钠肽＞125 pg/mL。", "label": 12, "label_text": "Laboratory Examinations", "id": "s2980"}
{"text": " ④任何影响干眼的状态 (比如全身应用抗组胺、抗炎药或激素)", "label": 5, "label_text": "Multiple", "id": "s2981"}
{"text": " 3. 入组前已有任何肺部结节病理诊断的患者；", "label": 11, "label_text": "Diagnostic", "id": "s2982"}
{"text": " 4.入选前6个月内有腹瘘、胃肠穿孔或腹腔内脓肿。", "label": 4, "label_text": "Disease", "id": "s2983"}
{"text": " ② 凝血功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s2984"}
{"text": " 鼻内用或系统使用皮质类固醇激素＜1月", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s2985"}
{"text": " 2．经过手术治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s2986"}
{"text": "1)患者已出现远处转移。（M1）", "label": 24, "label_text": "Neoplasm Status", "id": "s2987"}
{"text": " 3. 怀疑或确实有药物依赖史、滥用药物史，明显烟酒嗜好者(吸烟每天超过10支或等量的烟草）；喝酒每周超过28单位酒精(1单位= 285 ml啤酒或25ml烈酒或1玻璃杯葡萄酒)。", "label": 2, "label_text": "Addictive Behavior", "id": "s2988"}
{"text": " 9 病人自愿参加。", "label": 13, "label_text": "Consent", "id": "s2989"}
{"text": " (5)严重的机会性感染或肿瘤者；", "label": 4, "label_text": "Disease", "id": "s2990"}
{"text": " 4、原发性骨盆骨肿瘤无转移或仅有单发转移灶；", "label": 4, "label_text": "Disease", "id": "s2991"}
{"text": " 3).双侧卵巢存在;", "label": 4, "label_text": "Disease", "id": "s2992"}
{"text": " 2.年龄在20-45岁之间", "label": 3, "label_text": "Age", "id": "s2993"}
{"text": " 2. 有染色体病者；", "label": 4, "label_text": "Disease", "id": "s2994"}
{"text": " （4）患眼合并其它眼病，影响疗效判定者。", "label": 4, "label_text": "Disease", "id": "s2995"}
{"text": " 3.进行抗血小板药物治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s2996"}
{"text": " 2.UAS7评分≥ 28分；", "label": 9, "label_text": "Risk Assessment", "id": "s2997"}
{"text": " ④灰线移位。", "label": 4, "label_text": "Disease", "id": "s2998"}
{"text": " 9.其他经研究者判定不符合入选条件的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s2999"}
{"text": " 2.失能残障病人,同时具有视觉和听觉残疾的病人", "label": 33, "label_text": "Disabilities", "id": "s3000"}
{"text": " 2、预计在医院停留时间超过120小时。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s3001"}
{"text": " 3)符合中重度持续性变应性鼻炎诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3002"}
{"text": " （2） 患者及家属依从性不佳者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3003"}
{"text": " 4.已知对替吉奥胶囊、5-氟尿嘧啶、顺铂过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3004"}
{"text": " (5)先天性心脏病、严重肝胆疾病或免疫缺陷患儿；", "label": 4, "label_text": "Disease", "id": "s3005"}
{"text": " （7）过敏体质者或对本试验药物成分中已知有过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3006"}
{"text": " 5.纳入研究时美国东部肿瘤协作组（ECOG）评分0-３分，但运动量没有达到指南要求的患者。", "label": 5, "label_text": "Multiple", "id": "s3007"}
{"text": " 9. 近3个月参加过其它临床试验者或正在参加其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3008"}
{"text": "(1) 家属拒绝", "label": 13, "label_text": "Consent", "id": "s3009"}
{"text": " 2.12.病灶毗邻重要脏器，预计微波消融可能会造成严重并发症的；", "label": 5, "label_text": "Multiple", "id": "s3010"}
{"text": " 8）近3个月内参加其他临床试验的受试者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3011"}
{"text": " 15.拒绝行椎管内穿刺的患者；", "label": 5, "label_text": "Multiple", "id": "s3012"}
{"text": " 非烟酒刺激引起者；", "label": 5, "label_text": "Multiple", "id": "s3013"}
{"text": " 慢性肾病", "label": 4, "label_text": "Disease", "id": "s3014"}
{"text": " 3.受试者知情自愿签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3015"}
{"text": "1、急性ST段抬高前壁心梗（心肌酶升高；ST段抬高：相邻两个以上胸导联≥2mm，新出现的LBBB），发病&lt;14d。", "label": 5, "label_text": "Multiple", "id": "s3016"}
{"text": "（1）一年内曾患躯体疾病：心血管疾病、内分泌疾病（糖尿病、甲状腺疾病等）、肥胖、消化系统疾病（肝硬化、脂肪肝、肠易激综合征、炎性肠病等）、物质滥用等；", "label": 4, "label_text": "Disease", "id": "s3017"}
{"text": " （6）无肿瘤未侵犯门静脉，无超过一处以外的肝外转移(包括肝门淋巴结)；", "label": 24, "label_text": "Neoplasm Status", "id": "s3018"}
{"text": " 2. 明确诊断的UC患者(诊断标准参考第15版《实用内科学》）；于我院就诊的非UC患者；", "label": 4, "label_text": "Disease", "id": "s3019"}
{"text": "1)合并HIV-1感染或慢性丙型肝炎或梅毒等性传播疾病", "label": 4, "label_text": "Disease", "id": "s3020"}
{"text": " 2 具有重大器质性疾病者（如心脏病、肾病）；", "label": 4, "label_text": "Disease", "id": "s3021"}
{"text": " 9) 严重胃肠吸收功能障碍如吞咽困难、食管炎、肠炎或消化道溃疡的患者；", "label": 4, "label_text": "Disease", "id": "s3022"}
{"text": " 4.肿瘤符合手术适应症，无手术禁忌症，包括严重的心脑血管疾病、呼吸衰竭、精神障碍等", "label": 4, "label_text": "Disease", "id": "s3023"}
{"text": " 3）合并慢性阻塞性肺病患者", "label": 4, "label_text": "Disease", "id": "s3024"}
{"text": " 5）缓解Graves眼病患者：常规糖皮质激素冲击治疗后，NO SPECS和CAS评分显示病情缓解者", "label": 5, "label_text": "Multiple", "id": "s3025"}
{"text": " （4）女性患者必须是绝经后，即停经至少12个月，或研究开始前至少3个月手术绝育，或者妊娠试验阴性且同意在研究期间和研究结束后1个月内使用可靠的避孕方法避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3026"}
{"text": " （9）高血压病血压控制不良者（治疗后收缩压≥160mmHg且舒张压≥100mmHg者）；", "label": 5, "label_text": "Multiple", "id": "s3027"}
{"text": " 4.有干扰素治疗禁忌症如妊娠、没有控制的高血压、没有控制的糖尿病、没有控制的甲状腺疾病及已经诊断或怀疑有肌炎、肌病或周围神经病者、重度视网膜病变史或由其他证据表明为视网膜病变患者、严重的精神病史，尤其是抑郁症。严重的精神病定义为重症抑郁症或精神病、自杀企图、因精神病而住院或因精神病而有一段时间能力丧失。", "label": 5, "label_text": "Multiple", "id": "s3028"}
{"text": " （3）肝、肾功能不全", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3029"}
{"text": " ⑷1周内持续使用可能影响胃肠道功能药物(如H2RA、PPI、胃粘膜保护剂、抗酸制、胃肠动力药、抗胆碱能药物等，或具有类似作用的中药)者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3030"}
{"text": " 7）既往严重脑梗病史（有后遗症）", "label": 4, "label_text": "Disease", "id": "s3031"}
{"text": " 正常组纳入条件包括：无酒精性依赖病史，近三月饮酒折合乙醇量每周＜140g，无单次大量饮酒史（折合乙醇量&gt;80g/d），且近两周无饮酒，无明显肝功能异常及严重疾病发生；", "label": 5, "label_text": "Multiple", "id": "s3032"}
{"text": " 4）患者完全理解本临床验证的内容及要求，能够按照方案中规定的时间完成随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3033"}
{"text": " 6.在治疗开始前4周内曾接受他克莫司或环孢素治疗的；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3034"}
{"text": " 5.Karnofsky积分≥60%，东部肿瘤协作组（ECOG）体能状况评分0~2分；", "label": 9, "label_text": "Risk Assessment", "id": "s3035"}
{"text": " (2) 临床经病理学检查确诊为胃癌患者，依据NCCN指南（2017.V5）；", "label": 11, "label_text": "Diagnostic", "id": "s3036"}
{"text": " 11, 存在凝血功能障碍、活动性出血或出血倾向；", "label": 5, "label_text": "Multiple", "id": "s3037"}
{"text": " 2）中晚期原发性支气管肺癌患者化疗或放疗后；", "label": 5, "label_text": "Multiple", "id": "s3038"}
{"text": " ⑥有二甲双胍的禁忌症。", "label": 4, "label_text": "Disease", "id": "s3039"}
{"text": " ③无糖尿病及其他影响营养和代谢的内分泌疾患。", "label": 4, "label_text": "Disease", "id": "s3040"}
{"text": " ③ 曾经进行过大型腹部手术，尤其是肠道手术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3041"}
{"text": "1）患有眼内肿瘤，多有视物模糊。", "label": 5, "label_text": "Multiple", "id": "s3042"}
{"text": " ⑶妊娠期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3043"}
{"text": " 11.先天性心脏疾病、心律不齐、心力衰竭等严重的心血管疾病；", "label": 4, "label_text": "Disease", "id": "s3044"}
{"text": " （2）0.5%托比卡胺扩瞳验光：+0.5DS~-6.0DS之内；", "label": 1, "label_text": "Sign", "id": "s3045"}
{"text": " （4）高血压水平为1级，且导入期后坐位舒张压 90-99mmHg 和（或）收缩压 140-159mmHg者；", "label": 5, "label_text": "Multiple", "id": "s3046"}
{"text": " 6)正在参加其它临床试验或3 个月内参加过其它药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3047"}
{"text": " 7、对阿片类药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3048"}
{"text": " (4) 健康体检(包括体格检查、病史、生命体征、心电图和临床实验室检查结果)合格，和/或研究者认为异常临床无意义者。", "label": 21, "label_text": "Researcher Decision", "id": "s3049"}
{"text": " （9）血色素＜10g;", "label": 12, "label_text": "Laboratory Examinations", "id": "s3050"}
{"text": " （4）与用眼相关引发的头痛；", "label": 1, "label_text": "Sign", "id": "s3051"}
{"text": " 7.采样前1个月内有腹泻、痢疾等感染性胃肠道病史，与强直性脊柱炎病情相关的腹泻不在此范围内，", "label": 4, "label_text": "Disease", "id": "s3052"}
{"text": " 4.KPS评分80分以上", "label": 9, "label_text": "Risk Assessment", "id": "s3053"}
{"text": " 5.鼻腔及鼻咽部有阻塞者；", "label": 28, "label_text": "Symptom", "id": "s3054"}
{"text": " 5)受试者能够与研究者作良好的沟通并能够依照研究规定完成研究。", "label": 25, "label_text": "Literacy", "id": "s3055"}
{"text": " 8) 患者不愿或无法限制活动或遵照遗嘱；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3056"}
{"text": " 4)患者自愿参与本临床试验并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3057"}
{"text": " 3、伴有严重的或不稳定的心、肝、肾、内分泌、甲状腺功能低下、血液等内科疾病者。", "label": 4, "label_text": "Disease", "id": "s3058"}
{"text": " 5）恶性肿瘤和终末期疾病患者；", "label": 4, "label_text": "Disease", "id": "s3059"}
{"text": " 3. 产后2周以上；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3060"}
{"text": " （3）病人的腰椎、股骨近端须适于双能X线骨密度测量，不能有影响测量的严重脊柱侧弯、骨骼创伤、腰椎或髋部有内置物、骨科手术后遗症等，且腰椎椎体压缩骨折不超过1个椎体。", "label": 5, "label_text": "Multiple", "id": "s3061"}
{"text": " (5)实验室检查发现血液学指标异常，心、肝和肾功能不全者；", "label": 5, "label_text": "Multiple", "id": "s3062"}
{"text": " 4.存在有严重心脏病、心功能不全、肝功能障碍、肾功能不全，呼吸衰竭、恶性肿瘤等预计不能完成随访1年者；", "label": 5, "label_text": "Multiple", "id": "s3063"}
{"text": " 2. 所有育龄男女必须在进入筛选期后至完成研究至少3个月内均采取安全有效的避孕措施，女性受试者妊娠试验为阴性方可入选;", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3064"}
{"text": " 6、预计未来12个月内在现居住地居住不变；", "label": 40, "label_text": "Address", "id": "s3065"}
{"text": " (4) 由于心理、社会、家庭及地理原因不能配合定期随访的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3066"}
{"text": " E无其他不适宜参加临床试验因素。", "label": 21, "label_text": "Researcher Decision", "id": "s3067"}
{"text": " （6）一个月内未参加其他药物临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3068"}
{"text": "①两周内服用过其他防治血栓性疾病及影响血小板功能药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3069"}
{"text": " ② 腹部CT严重指数(CTSI) ≥6分；", "label": 9, "label_text": "Risk Assessment", "id": "s3070"}
{"text": " （4）骨髓造血功能正常，无出血倾向（INR&lt;1.5），血常规：HGB≥90g/L、WBC＞4.0×10^9/L（NEU≥1.5×10^9/L）、 PLT≥100×10^9/L；", "label": 5, "label_text": "Multiple", "id": "s3071"}
{"text": " 12.近期（30天）有颅内或椎管内手术及实质性脏器的活检。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3072"}
{"text": " 3、发病时间在2周以后，3个月以内的患者；", "label": 4, "label_text": "Disease", "id": "s3073"}
{"text": "小于1岁或大于18岁；", "label": 3, "label_text": "Age", "id": "s3074"}
{"text": " 5、合并其他系统严重疾病的患者；", "label": 4, "label_text": "Disease", "id": "s3075"}
{"text": " 3.伴有其它恶性肿瘤病史；", "label": 4, "label_text": "Disease", "id": "s3076"}
{"text": " （7）未控制的糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s3077"}
{"text": "（1）患者病情符合湿性年龄相关性黄斑变性、增殖性糖尿病视网膜病变、视网膜静脉阻塞诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3078"}
{"text": " （4）严重感染、心衰、中枢神经系统损害者", "label": 4, "label_text": "Disease", "id": "s3079"}
{"text": " 5、严重出血或出血倾向者，如活动性消化性溃疡、颅内出血、外伤或其他出血；", "label": 4, "label_text": "Disease", "id": "s3080"}
{"text": "1)对碘、丙泊酚、vitC等过敏的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3081"}
{"text": " 3.年龄≥30且≤70周岁；", "label": 3, "label_text": "Age", "id": "s3082"}
{"text": "1、既往参加过肺康复训练；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3083"}
{"text": "1、合并HIV、HCV或HDV的感染者", "label": 4, "label_text": "Disease", "id": "s3084"}
{"text": " 10)既往有大手术或二次手术史", "label": 0, "label_text": "Therapy or Surgery", "id": "s3085"}
{"text": " 6、治疗过程中不能有效配合者", "label": 8, "label_text": "Compliance with Protocol", "id": "s3086"}
{"text": "1 家属拒绝参加本研究", "label": 13, "label_text": "Consent", "id": "s3087"}
{"text": " 6. 距离上一次放疗7天内；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3088"}
{"text": "1. 目前居住在研究现场；", "label": 40, "label_text": "Address", "id": "s3089"}
{"text": "1.1周内心肌梗死。", "label": 4, "label_text": "Disease", "id": "s3090"}
{"text": " （4） 大量腹水；", "label": 1, "label_text": "Sign", "id": "s3091"}
{"text": " 3）服用可影响骨代谢的药物，比如抗骨吸收药物、降钙素、甲状腺素、甲状旁腺素和性激素替代治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3092"}
{"text": " 4）有不可纠正的凝血功能障碍和明显的血象异常，有明显的出血倾向者；", "label": 1, "label_text": "Sign", "id": "s3093"}
{"text": " (2)经NAs抗病毒治疗（所用NAs种类及方案，时长不限）并获得HBV低于20IU/ml,HBsAg低于1000IU/ml；", "label": 5, "label_text": "Multiple", "id": "s3094"}
{"text": " 正常妊娠对照纳入标准：", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3095"}
{"text": " 2)颅内出血史；", "label": 4, "label_text": "Disease", "id": "s3096"}
{"text": " 　　（8）对奥氮平过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3097"}
{"text": " (5)筛选前4周内有严重感染、外伤或外科大手术史；", "label": 5, "label_text": "Multiple", "id": "s3098"}
{"text": "（1）年龄18-70周岁，性别不限，NYHA心功能分级2～3级；", "label": 5, "label_text": "Multiple", "id": "s3099"}
{"text": "1. 符合《国际疾病分类第十版（ICD-10）》中“双相情感障碍，目前为不伴有精神病性症状的躁狂发作；", "label": 5, "label_text": "Multiple", "id": "s3100"}
{"text": "（1） 拒绝参加本研究", "label": 13, "label_text": "Consent", "id": "s3101"}
{"text": " 13. 怀孕期、哺乳期妇女，育龄期妇女及配偶拒绝采取有效的避孕方式避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3102"}
{"text": " 2、器官功能衰竭者:", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3103"}
{"text": " （2）处于严重的难以控制的局部或全身急、慢性感染，可能影响试验用药或者临床评估者；", "label": 5, "label_text": "Multiple", "id": "s3104"}
{"text": "1.年龄18～65岁、体重45-80kg的女性；", "label": 5, "label_text": "Multiple", "id": "s3105"}
{"text": "        短暂性脑缺血发作受试者发病7天内入组，且ABCD2≥4；", "label": 4, "label_text": "Disease", "id": "s3106"}
{"text": " 5）中医证型属于气滞腑实者。", "label": 11, "label_text": "Diagnostic", "id": "s3107"}
{"text": " 17)研究者认为不应纳入者；", "label": 21, "label_text": "Researcher Decision", "id": "s3108"}
{"text": " 3.有神经阻滞禁忌症，如凝血功能障碍，全身或穿刺部位有感染、局麻药过敏、神经损伤等；", "label": 5, "label_text": "Multiple", "id": "s3109"}
{"text": " 2.FSH≥15IU/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3110"}
{"text": " 4.研究者认为存在可能损害受试者或者导致受试者无法满足或执行研究要求的任何状况", "label": 21, "label_text": "Researcher Decision", "id": "s3111"}
{"text": " 2.sepsis或septic shock患者（符合sepsis3.0的诊断标准）", "label": 11, "label_text": "Diagnostic", "id": "s3112"}
{"text": " 4.有癫痫或发热惊厥病史患儿、反复呼吸道感染患儿；", "label": 4, "label_text": "Disease", "id": "s3113"}
{"text": " 7.患者能够理解试验的内容及意义，自愿参加本试验并签署同意书。", "label": 5, "label_text": "Multiple", "id": "s3114"}
{"text": " ⑻怀疑或确有酒精、药品滥用病史，或者根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，如工作环境经常变动等易造成失访的情况；", "label": 5, "label_text": "Multiple", "id": "s3115"}
{"text": " ③ 哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3116"}
{"text": " 2.年龄30~75岁；", "label": 3, "label_text": "Age", "id": "s3117"}
{"text": " 5.经药物保守治疗失败；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3118"}
{"text": " 15、哺乳期、妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3119"}
{"text": " 6、严重心功能不全；ALT超过正常值2.5倍、Cr异常；", "label": 5, "label_text": "Multiple", "id": "s3120"}
{"text": " 11.已知的人免疫缺陷病毒（HIV）或乙型或丙型类病毒性肝炎的活动期病毒感染；", "label": 4, "label_text": "Disease", "id": "s3121"}
{"text": "1）严重下肢缺血的DFO患者（ABI&lt;0.4,或者TcPO2&lt;20mmHg);", "label": 5, "label_text": "Multiple", "id": "s3122"}
{"text": " 12、妊娠期及哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3123"}
{"text": " 5.伴有1种及以上的糖尿病并发症（糖尿病视网膜病变、糖尿病神经病变、糖尿病肾病、糖尿病足等）；", "label": 4, "label_text": "Disease", "id": "s3124"}
{"text": " 2. 非单纯基底节区梗死伴失语的患者；", "label": 4, "label_text": "Disease", "id": "s3125"}
{"text": "  2．胰腺头部良性肿瘤或胰腺体尾部肿瘤", "label": 4, "label_text": "Disease", "id": "s3126"}
{"text": " 无远处转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s3127"}
{"text": " ④自愿参加试验，能够完成后期随访。", "label": 5, "label_text": "Multiple", "id": "s3128"}
{"text": " （3）年龄16-55岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s3129"}
{"text": " 3）有肥厚型心肌病、扩张型心肌病、预激综合征、严重贫血、病毒性心肌炎、甲状腺功能亢进者；", "label": 4, "label_text": "Disease", "id": "s3130"}
{"text": " 8.主要器官功能正常，即符合下列标准：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3131"}
{"text": " 4、肥胖(BMI&gt;30);", "label": 5, "label_text": "Multiple", "id": "s3132"}
{"text": "1  性别不限，年龄18～70岁；", "label": 5, "label_text": "Multiple", "id": "s3133"}
{"text": " 4.合并恶性肿瘤或其他严重疾病患者", "label": 4, "label_text": "Disease", "id": "s3134"}
{"text": " 15、试验期间不能停硝普钠、脑钠肽(BNP)、心钠肽(ANP)、静脉滴注利尿剂者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3135"}
{"text": " 2) 诊断明确，但是按照IIRC分期，属于Group A的患者和Group E期具有高危因素的患者，其中Group B中局部激光治疗可以治愈的病人排除。", "label": 5, "label_text": "Multiple", "id": "s3136"}
{"text": "1.14日之内曾患有呼吸道感染或急性副鼻窦炎者；胸部X片出现炎症现象者；", "label": 5, "label_text": "Multiple", "id": "s3137"}
{"text": "a）男性健康志愿者，18～40岁，包括边界值；同批年龄相差不超过10岁；", "label": 5, "label_text": "Multiple", "id": "s3138"}
{"text": " （2）年龄≥18岁、≤60岁；", "label": 3, "label_text": "Age", "id": "s3139"}
{"text": "1.入住ICU接受机械通气治疗≥12h的患者；", "label": 38, "label_text": "Nursing", "id": "s3140"}
{"text": " 2）能够完成冲击波治疗期间以及治疗后每个随访节点的随访工作；", "label": 5, "label_text": "Multiple", "id": "s3141"}
{"text": " (9)肾功能不全患者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3142"}
{"text": " （2）神志不清、痴呆、各种精神病患者；", "label": 4, "label_text": "Disease", "id": "s3143"}
{"text": " （8）严重的心、脑、肾等疾病；", "label": 4, "label_text": "Disease", "id": "s3144"}
{"text": " 3.本市常住", "label": 40, "label_text": "Address", "id": "s3145"}
{"text": " 2.既往诊断双相情感障碍者、精神分裂症、分裂情感性精神障碍及其它疾病伴发的精神障碍者", "label": 4, "label_text": "Disease", "id": "s3146"}
{"text": " 5. 无泌尿系统感染者。", "label": 4, "label_text": "Disease", "id": "s3147"}
{"text": "1)已确诊为血液系统其他疾病", "label": 11, "label_text": "Diagnostic", "id": "s3148"}
{"text": " （5）初发且未接受过肿瘤化疗或放疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3149"}
{"text": " ⑦受试者同意并已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3150"}
{"text": " 3.合并需要手术切除子宫的子宫肌瘤、子宫腺疾病、宫颈疾病等", "label": 5, "label_text": "Multiple", "id": "s3151"}
{"text": " 4）不适合使用普萘洛尔/伊曲康唑治疗的患儿；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3152"}
{"text": "1）年龄18-45岁", "label": 3, "label_text": "Age", "id": "s3153"}
{"text": " 2.对该临床试验知情同意", "label": 13, "label_text": "Consent", "id": "s3154"}
{"text": "1）多器官移植；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3155"}
{"text": "1.年龄&gt;14岁的男性或女性", "label": 5, "label_text": "Multiple", "id": "s3156"}
{"text": "  (2)有精神障碍、老年痴呆、认知障碍者;", "label": 4, "label_text": "Disease", "id": "s3157"}
{"text": " （4）有严重、未控制的器质性病变或感染，如失代偿的心、肺、肾功能衰竭等导致不能耐受放疗的患者；", "label": 5, "label_text": "Multiple", "id": "s3158"}
{"text": " 17.入组前6个月内存在深静脉血栓或肺栓塞病史；", "label": 4, "label_text": "Disease", "id": "s3159"}
{"text": " 3.一侧肢体偏瘫;", "label": 4, "label_text": "Disease", "id": "s3160"}
{"text": " 接受冻融胚胎移植；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3161"}
{"text": " NDRI类抗抑郁药（如安非他酮等）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3162"}
{"text": " 8）下丘脑、垂体肿瘤者；", "label": 4, "label_text": "Disease", "id": "s3163"}
{"text": " ⑦肝肾功能：总胆红素&gt;正常值上限(ULN)的1.5倍；天冬氨酸转氨酶（AST）、谷丙转氨酶（ALT）&gt;ULN的2.5 倍；血清肌酐&gt;正常值上限的1.5 倍，且肌酐清除率&lt; 60 ml/min；", "label": 5, "label_text": "Multiple", "id": "s3164"}
{"text": " 3.病程2年以上", "label": 4, "label_text": "Disease", "id": "s3165"}
{"text": " 5 自愿受试，知情同意。", "label": 13, "label_text": "Consent", "id": "s3166"}
{"text": "1.年龄在40-79岁之间（含40岁、79岁）。", "label": 3, "label_text": "Age", "id": "s3167"}
{"text": " 4.无全身性感染；", "label": 4, "label_text": "Disease", "id": "s3168"}
{"text": "1、符合2008年中华医学会呼吸病学分会哮喘学组制定的诊断标准的轻中度哮喘持续期患者。", "label": 11, "label_text": "Diagnostic", "id": "s3169"}
{"text": " 6.存在心血管、呼吸、肝脏、肾脏、胃肠道，内分泌或神经方面可能改变药物吸收、代谢或清除的紊乱的病史；", "label": 5, "label_text": "Multiple", "id": "s3170"}
{"text": " 3)既往发生过眼球破裂伤等眼外伤者；", "label": 4, "label_text": "Disease", "id": "s3171"}
{"text": " 3.精神病患者", "label": 4, "label_text": "Disease", "id": "s3172"}
{"text": " (13)药物滥用者、烟酒嗜好者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3173"}
{"text": " 3.年龄不限，性别不限", "label": 5, "label_text": "Multiple", "id": "s3174"}
{"text": " 3. 持续气流受限（吸入支气管扩张剂后的FEV1/FVC&lt;0.7）；", "label": 5, "label_text": "Multiple", "id": "s3175"}
{"text": "1.铁营养状况正常；", "label": 18, "label_text": "Diet", "id": "s3176"}
{"text": " 8)血象和肝肾功能：中性粒白细胞计数≥1500/mm3,血小板≥100,000/mm3血红蛋白≥ 100g/l,转氨酶≤2.5×正常值上限, 胆红素≤1.5×正常值上限,AKP≤5×正常上限,肌酐≤1.5mg/dl;", "label": 12, "label_text": "Laboratory Examinations", "id": "s3177"}
{"text": " 2.肿瘤可通过手术进行切除的乙状结肠癌或直肠上段癌（距离肛门8cm以上）", "label": 5, "label_text": "Multiple", "id": "s3178"}
{"text": " 12)合并使用影响糖代谢的药物，如糖皮质激素、甲状腺素、噻嗪类利尿剂", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3179"}
{"text": " 3.HbA1c≥7%且?10%；FBG?11.1 mmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3180"}
{"text": "（1）1个月内治疗大疱性类天疱疮的用药方案或剂量有改变者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3181"}
{"text": " 2) 符合要求并获得知情同意书；", "label": 13, "label_text": "Consent", "id": "s3182"}
{"text": " （3）严重心、肺、肾等脏器疾病者。", "label": 4, "label_text": "Disease", "id": "s3183"}
{"text": "① 牙齿解剖结构异常；", "label": 30, "label_text": "Oral related", "id": "s3184"}
{"text": "1.年龄18-60岁；", "label": 3, "label_text": "Age", "id": "s3185"}
{"text": "            单纯性非复发胬肉；", "label": 4, "label_text": "Disease", "id": "s3186"}
{"text": " 6.术前BMI≥18.5kg/㎡；", "label": 9, "label_text": "Risk Assessment", "id": "s3187"}
{"text": " 6.切除病灶的任意一侧切缘&lt;2cm；", "label": 4, "label_text": "Disease", "id": "s3188"}
{"text": " (6)有急、慢性消化道疾病和心、肝、肾等重要器官疾病史者；", "label": 4, "label_text": "Disease", "id": "s3189"}
{"text": " 4.由于智力障碍不能给予充分知情同意者", "label": 13, "label_text": "Consent", "id": "s3190"}
{"text": " 2、已行腺样体切除术或鼓膜置管术的；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3191"}
{"text": " （10）近4周内参加过其他药物临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3192"}
{"text": " 9)妊娠、哺乳或有意妊娠，或判断为未使用足够的避孕措施（足够的避孕措施是指宫内节育器、口服避孕药及阻碍措施）。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3193"}
{"text": " （3）一个月内参加过其它药物试验的受试者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3194"}
{"text": " (3)合并有消化道出血病史、严重的消化道溃疡等消化系统疾病。", "label": 4, "label_text": "Disease", "id": "s3195"}
{"text": "        c)颈静脉怒张 &gt; 8 cm；", "label": 1, "label_text": "Sign", "id": "s3196"}
{"text": " （4）同期服用拟胆碱能或抗胆碱能药物及对认知功能有影响的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3197"}
{"text": " 11、有化疗禁忌。", "label": 4, "label_text": "Disease", "id": "s3198"}
{"text": " （4）严重的肝、肾功能不全者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3199"}
{"text": " 6）伴有慢性肝、肾等重要脏器实质性病变者；", "label": 4, "label_text": "Disease", "id": "s3200"}
{"text": "1.符合西医卵巢低预后不孕诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3201"}
{"text": " 5）重要系统并发症，如COPD、心脏病等；", "label": 4, "label_text": "Disease", "id": "s3202"}
{"text": " 2. 其他原因不适合临床试验者；", "label": 21, "label_text": "Researcher Decision", "id": "s3203"}
{"text": " 2.胶质瘤浸润破坏左侧弓形束患者。", "label": 4, "label_text": "Disease", "id": "s3204"}
{"text": " 6.已知对盐酸二甲双胍和本品中的任何成份过敏。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3205"}
{"text": " 3、术中出血大于1000ml的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s3206"}
{"text": " 2、符合我临床中心手术指征（指征：【1】6个月保守治疗无效【2】伸直&gt;30°或屈曲&lt;130°【3】患者有手术意愿；绝对禁忌征：【1】存在发展中的异位骨化【2】关节软骨完全破坏【3】局部存在软组织感染史【4】无法耐受手术情况【5】术后无法配合功能锻炼；相对禁忌征：骨折未愈合）；", "label": 5, "label_text": "Multiple", "id": "s3207"}
{"text": "1、多脏器联合移植者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3208"}
{"text": " 8.妊娠或准备妊娠妇女，哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3209"}
{"text": " 7)恶液质，器官功能失代偿；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3210"}
{"text": " 3)血尿酸=7-9mg/dl（420-540μmol/L）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3211"}
{"text": " （10）男性受试者在接受治疗及完成化疗后的1个月内应采取有效避孕措施。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3212"}
{"text": " （4）肿瘤患者及其他经心内科专家认定不适合参加试验者；", "label": 21, "label_text": "Researcher Decision", "id": "s3213"}
{"text": " （1）年龄18-40岁之间女性患者；", "label": 5, "label_text": "Multiple", "id": "s3214"}
{"text": " 2. 一般状况： ECOG PS 0-1；", "label": 9, "label_text": "Risk Assessment", "id": "s3215"}
{"text": " 4)自愿加入本实验，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3216"}
{"text": " （2）根据Hanifin和Rajka诊断标准诊断为特应性皮炎；", "label": 11, "label_text": "Diagnostic", "id": "s3217"}
{"text": " （2）入组前除非小细胞肺癌脑转移外有其他活动性恶性肿瘤病史的患者", "label": 5, "label_text": "Multiple", "id": "s3218"}
{"text": " ② 活动性或未能控制的严重感染；", "label": 4, "label_text": "Disease", "id": "s3219"}
{"text": " 2、自愿签署知情同意书者；", "label": 13, "label_text": "Consent", "id": "s3220"}
{"text": "1）试验前病史、体检、实验室项目及试验相关各项检查、检测均正常或无临床意义的轻度异常，临床研究医生判断认为合格的健康中国男性", "label": 5, "label_text": "Multiple", "id": "s3221"}
{"text": " 3. 伴发可导致增加治疗损伤的眼部疾病，例如：任何一只眼睛活动性的眼部感染或炎症；在基线检查前三个月内有眼部手术或外伤；任何一只眼睛存在可能影响角膜完整性的眼表异常；任何一只眼有影响眼睑功能的眼睑异常；", "label": 5, "label_text": "Multiple", "id": "s3222"}
{"text": " (7) 实验室检查(血尿常规、肝肾功能、心电图检查和术前四项)发现血液学指标异常，心、肝和肾 功能不全者；", "label": 5, "label_text": "Multiple", "id": "s3223"}
{"text": " 4. 有严重的其它系统疾病需要治疗者", "label": 4, "label_text": "Disease", "id": "s3224"}
{"text": " 7)在筛选前14天内使用了任何处方药、非处方药、任何维生素产品或草药（除外抗乙肝核苷（酸）类似物）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3225"}
{"text": " 3. 稳定性心绞痛患者；", "label": 4, "label_text": "Disease", "id": "s3226"}
{"text": " 2. 恶性肿瘤需行扩大根治术者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3227"}
{"text": "1. 组织学或细胞学确诊为恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s3228"}
{"text": " 2.入选前已经存在静脉血栓栓塞性疾病者", "label": 4, "label_text": "Disease", "id": "s3229"}
{"text": " （7） 12导联心电图检查异常且有临床意义者，包括心律失常和QT明显异常（QTcF间期?450msec）者；", "label": 5, "label_text": "Multiple", "id": "s3230"}
{"text": " 7. 签署知情同意书;", "label": 13, "label_text": "Consent", "id": "s3231"}
{"text": " 4.合并有严重心脏疾病（慢性心衰纽约分级标准：心功能3级以上者）、慢性肺部疾病、严重肝脏疾病（AST、ALT正常值上限2倍者）和造血系统（除外肾性贫血）等严重疾病者、精神疾患者。", "label": 5, "label_text": "Multiple", "id": "s3232"}
{"text": " ?由于智力障碍、不愿意交流或语言障碍，妨碍在本研究中充分的理解、合作，或者影响血糖监测仪使用的患者；", "label": 5, "label_text": "Multiple", "id": "s3233"}
{"text": " 3）年龄18-70岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s3234"}
{"text": " 7．患者签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3235"}
{"text": "1、孕妇和哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3236"}
{"text": " e. 使用α-糖苷酶抑制剂者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3237"}
{"text": " 3)组织病理学确诊为浸润性乳腺癌，隐匿性乳腺癌、炎性乳腺癌和湿疹样癌除外；", "label": 11, "label_text": "Diagnostic", "id": "s3238"}
{"text": " 3. 尿道综合征", "label": 4, "label_text": "Disease", "id": "s3239"}
{"text": " (3)年龄不足20岁或超过55岁者，妊娠或哺乳期患者。", "label": 5, "label_text": "Multiple", "id": "s3240"}
{"text": " 3.肝肾功能正常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3241"}
{"text": " 4)肾功能不全（肾小球滤过率＜70ml/min，或肌酐超过正常值上限）；", "label": 5, "label_text": "Multiple", "id": "s3242"}
{"text": " （7）受试者有临床症状的中枢神经系统转移（如脑水肿、需要激素干预，或脑转移进展）；", "label": 4, "label_text": "Disease", "id": "s3243"}
{"text": " 3、原发性闭角型青光眼：具有青光眼的视盘改变，RNFL及视野损害，眼压&gt;21mmHg, 前房角变窄或关闭", "label": 5, "label_text": "Multiple", "id": "s3244"}
{"text": " （6）肺间质纤维化", "label": 4, "label_text": "Disease", "id": "s3245"}
{"text": " （3）脊柱病灶接受或即将接受手术治疗。对于接受或即将接受经皮椎体成形术，或≤3个椎体的后路内固定术的患者，手术对MRI成像影响不大，经实验者评估，可入组本试验。", "label": 5, "label_text": "Multiple", "id": "s3246"}
{"text": " 6、自愿受试，并获得书面知情同意。", "label": 13, "label_text": "Consent", "id": "s3247"}
{"text": " ②　有老年痴呆、严重听觉、语言交流、躯体活动，精神障碍患者。", "label": 4, "label_text": "Disease", "id": "s3248"}
{"text": " ③4周内采取过其他治疗措施治疗颞下颌关节紊乱病或服用过类似药物；", "label": 5, "label_text": "Multiple", "id": "s3249"}
{"text": " 4.进行颅脑神经外科手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3250"}
{"text": "1. 通过McCarty标准诊断为慢性膝焦磷酸钙沉积病；", "label": 11, "label_text": "Diagnostic", "id": "s3251"}
{"text": " 7.通过医生检查有皮下脂肪增生存在", "label": 11, "label_text": "Diagnostic", "id": "s3252"}
{"text": " （3） 术前未行任何抗肿瘤药物治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3253"}
{"text": " （3）体重不少于45kg，BMI在19-24之间[BMI=体重(kg)/身高2(m2)]。", "label": 5, "label_text": "Multiple", "id": "s3254"}
{"text": " (10)肌酐清除率 (CLCr)大于等于70 mL/min；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3255"}
{"text": " ③ 病程在1年以内；或病程在半年以上，但未接受正规治疗者；", "label": 5, "label_text": "Multiple", "id": "s3256"}
{"text": " 7.术前3周内没有接受过肠外营养的病人；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3257"}
{"text": "①年龄18-75岁的女性患者。", "label": 5, "label_text": "Multiple", "id": "s3258"}
{"text": "1. 年龄18-65周岁；", "label": 3, "label_text": "Age", "id": "s3259"}
{"text": " 3. 全身状况良好，无任何系统性疾病，无过敏史。", "label": 5, "label_text": "Multiple", "id": "s3260"}
{"text": " 5 有癫痫病史", "label": 4, "label_text": "Disease", "id": "s3261"}
{"text": " ⑶ 酸中毒、高渗性非酮症昏迷，严重脱水、严重电解质紊乱等患者；", "label": 4, "label_text": "Disease", "id": "s3262"}
{"text": " 2.年龄 18-60岁；", "label": 3, "label_text": "Age", "id": "s3263"}
{"text": " 8、预计术后生存期高于2年以上；", "label": 23, "label_text": "Life Expectancy", "id": "s3264"}
{"text": " （3）患者年龄为18-60岁；", "label": 3, "label_text": "Age", "id": "s3265"}
{"text": " 4）合并致死性并发症，严重感染、多脏器功能衰竭等；", "label": 4, "label_text": "Disease", "id": "s3266"}
{"text": " 2.有择期再次手术计划者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3267"}
{"text": " 全身已发生广泛转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s3268"}
{"text": "1  非肿瘤放化疗后血小板减少", "label": 12, "label_text": "Laboratory Examinations", "id": "s3269"}
{"text": " 2、持续的气流受限（吸入支气管舒张剂后，FEV1/FVC&lt;0.70）；", "label": 5, "label_text": "Multiple", "id": "s3270"}
{"text": " 3．有酗酒史（每周饮用14个单位的酒精：1单位=啤酒285 mL，或烈酒25 mL，或葡萄酒100ml）；", "label": 5, "label_text": "Multiple", "id": "s3271"}
{"text": " 2.确诊风湿免疫病包括：系统性红斑狼疮、大动脉炎、白塞病、原发性干燥综合征；", "label": 4, "label_text": "Disease", "id": "s3272"}
{"text": " ⑤无斜弱视；", "label": 4, "label_text": "Disease", "id": "s3273"}
{"text": "（1）、受试者自愿同意参加本试验并签署书面知情同意书；", "label": 13, "label_text": "Consent", "id": "s3274"}
{"text": " (2）年龄≥18岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s3275"}
{"text": " 研究者认为不适合参加本试验的其他疾病或情况。", "label": 21, "label_text": "Researcher Decision", "id": "s3276"}
{"text": " 2）合并其他类型血液疾病；", "label": 4, "label_text": "Disease", "id": "s3277"}
{"text": " 2)对已知试验药物过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s3278"}
{"text": " 2）交流障碍、无法配合研究者，如语言理解障碍、精神疾病等；", "label": 5, "label_text": "Multiple", "id": "s3279"}
{"text": " ?术后病检证实ER、PR、HER-2均为阴性；或ER、PR阴性/阳性，HER-2阳性（但不愿接受赫赛汀治疗者）", "label": 12, "label_text": "Laboratory Examinations", "id": "s3280"}
{"text": " 4.入组前有严重器官功能障碍（心功NY Heart Association class III–IV，肺功中-重度受损，肝功CTP C级，肾功障碍需要透析）。", "label": 5, "label_text": "Multiple", "id": "s3281"}
{"text": " ②BMI≥40kg/m2和（或）BMI＞ 35kg/m2且合并其他内科疾病；", "label": 5, "label_text": "Multiple", "id": "s3282"}
{"text": "1.术前有严重合并症的患者；", "label": 4, "label_text": "Disease", "id": "s3283"}
{"text": " 3、肌酐清除率&lt;50ml/min", "label": 12, "label_text": "Laboratory Examinations", "id": "s3284"}
{"text": " 6.急腹症，或有其他手术适应症（合并复杂瘘、纤维性狭窄致肠梗阻等）。", "label": 4, "label_text": "Disease", "id": "s3285"}
{"text": " 6. 既往有物质依赖病史", "label": 4, "label_text": "Disease", "id": "s3286"}
{"text": " 2）年龄0～80岁；", "label": 3, "label_text": "Age", "id": "s3287"}
{"text": " （9）患者对HP药敏试验抗生素任一药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3288"}
{"text": "1.明确诊断为ADA缺乏型重症联合免疫缺陷患者，同时具有ADA致病性变异。", "label": 4, "label_text": "Disease", "id": "s3289"}
{"text": " 2.发病前mRS≥2分；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3290"}
{"text": " （9） 签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3291"}
{"text": " 4.术前行CT/MRI/PET-CT检查提示无远处转移，有或无盆腔肿大淋巴结（≥5mm）", "label": 5, "label_text": "Multiple", "id": "s3292"}
{"text": " 2.患者躯体状况不符合MECT要求，具有MECT禁忌症。", "label": 4, "label_text": "Disease", "id": "s3293"}
{"text": " 12.女性患者处于孕期或哺乳期。证实患者未处于孕期必须由筛选期进行的血清?-人绒毛膜促性腺激素(?-hCG)妊娠试验的阴性结果来确证。对于绝经后或手术造成的不孕女性不需进行妊娠试验。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3294"}
{"text": "         Group1：肿瘤个数≥3个；", "label": 4, "label_text": "Disease", "id": "s3295"}
{"text": " （5）复发肿瘤距大血管或其一级分支以及临近器官0.5cm以上", "label": 24, "label_text": "Neoplasm Status", "id": "s3296"}
{"text": "经前列腺穿刺活检或术前诊断良性前列腺增生（Benign prostate hyperplasia，BPH）但行手术后病理诊断为前列腺腺癌的患者；", "label": 11, "label_text": "Diagnostic", "id": "s3297"}
{"text": "起病三月内的带状疱疹性神经痛患者（胸段）", "label": 4, "label_text": "Disease", "id": "s3298"}
{"text": " 7.有任何临床严重疾病史者，如呼吸系统、循环系统、消化系统、泌尿生殖系统、血液系统、代谢及内分泌系统、运动系统、神经精神系统、肌肉骨骼系统等。", "label": 4, "label_text": "Disease", "id": "s3299"}
{"text": "1.未于我院行超声检查患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3300"}
{"text": " 2）吸入支气管舒张剂后FEV1/FVC&lt;70%；", "label": 5, "label_text": "Multiple", "id": "s3301"}
{"text": "1.女性，年龄40-60岁；", "label": 5, "label_text": "Multiple", "id": "s3302"}
{"text": "（1）年龄在15-80岁", "label": 3, "label_text": "Age", "id": "s3303"}
{"text": "a) 未能完成知觉认识训练者；", "label": 17, "label_text": "Capacity", "id": "s3304"}
{"text": " （2） 能正常接听电话；", "label": 17, "label_text": "Capacity", "id": "s3305"}
{"text": " 研究用药开始前12个月内曾出现有过一下任何一种情况：严重不稳定心绞痛、心肌梗塞、冠状动脉搭桥术、症状性的充血性心力衰竭、严重的二尖瓣狭窄。", "label": 4, "label_text": "Disease", "id": "s3306"}
{"text": " 10、患者不愿或不能依从研究程序，或在研究治疗期间可能脱离观察1个疗程或以上", "label": 8, "label_text": "Compliance with Protocol", "id": "s3307"}
{"text": "1. 合并有肺部感染、肺结核、支气管癌、支气管肺炎或其他肺部疾病者。", "label": 4, "label_text": "Disease", "id": "s3308"}
{"text": " ⑥近3个月内用过其它治疗绝经相关症状的药物（如替勃龙，黑升麻提取物或大豆异黄酮类、及维生素类等）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3309"}
{"text": " 8.诊断为艾滋病毒/艾滋病或肝脏疾病的患者；", "label": 4, "label_text": "Disease", "id": "s3310"}
{"text": " （6） 不能遵循方案要求的随访，或者研究者认为受试者参加研究会增加风险者；", "label": 5, "label_text": "Multiple", "id": "s3311"}
{"text": "a) 符合脑梗塞或脑出血诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3312"}
{"text": " 14.经医生判断，还有不适合进行临床研究其他情况存在的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s3313"}
{"text": " （7）全身情况衰竭，预计生存期&lt;3月；", "label": 5, "label_text": "Multiple", "id": "s3314"}
{"text": " 5.肝功Pugh-Child A级。", "label": 9, "label_text": "Risk Assessment", "id": "s3315"}
{"text": "1.卵巢储备功能下降（DOR）为器质性病变、卵巢手术、放化疗引起者；", "label": 5, "label_text": "Multiple", "id": "s3316"}
{"text": " (6) AST、ALT高于正常上限2.5倍和/或血清肌酐≥133μmol/L（1.5mg/dL）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3317"}
{"text": " ?11.正在参加其它临床试验或参加过其它药物临床试验结束未超过3个月者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3318"}
{"text": "1.年龄在 18～70岁，男女兼可。", "label": 5, "label_text": "Multiple", "id": "s3319"}
{"text": " 8.有酗酒史（每日饮酒250ml以上）；", "label": 2, "label_text": "Addictive Behavior", "id": "s3320"}
{"text": " 1.年龄18-40岁；", "label": 3, "label_text": "Age", "id": "s3321"}
{"text": " 2、病程早期（发病7天内）出现器官功能（呼吸、循环、肾脏）衰竭（修订版Marshall评分≥2分），且持续时间达7天；", "label": 5, "label_text": "Multiple", "id": "s3322"}
{"text": " b.年龄为18-80岁的成年男性或女性。", "label": 5, "label_text": "Multiple", "id": "s3323"}
{"text": "1、脑瘫儿童组：年龄：4-12岁；GMFMCS分级Ⅰ、Ⅱ级；能准确听指令，能配合指令；可识别数字或颜色；在无辅具的情况可至少步行10米。", "label": 5, "label_text": "Multiple", "id": "s3324"}
{"text": " 4.具有符合RECIST 1.1标准的客观瘤灶，可以采用CT/MRI评价疗效；", "label": 11, "label_text": "Diagnostic", "id": "s3325"}
{"text": "1. 符合小儿急性上呼吸道感染西医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3326"}
{"text": " 有精神、心理疾患及其他不能配合完成研究者。", "label": 4, "label_text": "Disease", "id": "s3327"}
{"text": " 6.血清总胆红素和肌酐不超过正常上限1.5倍", "label": 12, "label_text": "Laboratory Examinations", "id": "s3328"}
{"text": "1. 年龄18-70岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s3329"}
{"text": " 11)怀孕或哺乳期女性，研究期间不愿意采取避孕措施的育龄女性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3330"}
{"text": " 9)合并器质性眼病：白内障、青光眼、眼底病、角膜病；", "label": 4, "label_text": "Disease", "id": "s3331"}
{"text": "①入院时伴有重症感染或上消化道出血者；", "label": 4, "label_text": "Disease", "id": "s3332"}
{"text": " 2. 至少之前一年内有常年性过敏性鼻炎和过敏性哮喘的典型症状史；", "label": 4, "label_text": "Disease", "id": "s3333"}
{"text": " 6.过敏体质，已知对钙或维生素D过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3334"}
{"text": " (6) 非烟酒嗜好者。", "label": 2, "label_text": "Addictive Behavior", "id": "s3335"}
{"text": " 6.愿意遵守本项研究的避孕要求。", "label": 13, "label_text": "Consent", "id": "s3336"}
{"text": "1.临床影像学LDCT检测发现肺部偶发结节人群；", "label": 4, "label_text": "Disease", "id": "s3337"}
{"text": "a. 手术区域存在感染或炎症者；", "label": 4, "label_text": "Disease", "id": "s3338"}
{"text": "1.从食物摄取的钙或者钙补充剂 &gt;800mg/天，或者血清钙离子浓度 ≥2.75 mmol/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s3339"}
{"text": " 16) 对饮食有特殊要求，不能遵守统一饮食者；", "label": 18, "label_text": "Diet", "id": "s3340"}
{"text": " 10)已知免疫功能低下或患有获得性、先天性免疫缺陷疾病，或有器官移植史；", "label": 5, "label_text": "Multiple", "id": "s3341"}
{"text": " (2)经检查证实由妇科肿瘤(子宫肌瘤最大直径大于3cm、粘膜下肌瘤、卵巢囊肿)、滴虫性阴道炎、外阴阴道假丝酵母菌病、细菌性阴道病、急性宫颈炎、盆腔炎性疾病、子宫内膜异位症、子宫腺肌病、盆腔静脉瘀血综合征、间质性膀胱炎(IC)等其它病症引起的相关症状者；", "label": 5, "label_text": "Multiple", "id": "s3342"}
{"text": " 7.参加其他临床实验的病人", "label": 15, "label_text": "Enrollment in other studies", "id": "s3343"}
{"text": "1．临床分期为ⅡA、ⅡB原发性乳腺癌患者，无保乳意愿；", "label": 5, "label_text": "Multiple", "id": "s3344"}
{"text": " [7]基线前1个月内参加其他任何临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3345"}
{"text": " (5)受试者年龄18～65岁。", "label": 3, "label_text": "Age", "id": "s3346"}
{"text": " 8)有血管性水肿病史者等", "label": 4, "label_text": "Disease", "id": "s3347"}
{"text": " （3）择期全麻下行手术的患儿", "label": 0, "label_text": "Therapy or Surgery", "id": "s3348"}
{"text": " 14)女性受试者在筛查期或试验过程中正处在哺乳期或血清妊娠结果阳性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3349"}
{"text": " 2、病情程度属轻度、中度、重度的急性加重期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s3350"}
{"text": " ②临床诊断为泪道阻塞或慢性泪囊炎", "label": 11, "label_text": "Diagnostic", "id": "s3351"}
{"text": " 配合规律随访。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3352"}
{"text": " 3）卵巢囊肿性质不明", "label": 1, "label_text": "Sign", "id": "s3353"}
{"text": " （3）曾使用过明确会引起神经病变的药物（如长春新碱），曾患有可能会引起神经病变的疾病，如恶性贫血和甲状腺机能减退；", "label": 5, "label_text": "Multiple", "id": "s3354"}
{"text": " ⑤孕期发现有重大疾病者；", "label": 4, "label_text": "Disease", "id": "s3355"}
{"text": " （7）术前ASA评分Ⅰ-Ⅲ；", "label": 9, "label_text": "Risk Assessment", "id": "s3356"}
{"text": " 4.有精神性疾病或有严重的认知缺损；", "label": 4, "label_text": "Disease", "id": "s3357"}
{"text": " （7）Hgb&lt;7g/dl或凝血功能严重异常，PT&gt;正常值10s以上，或血小板&lt;60×10^9/L；", "label": 5, "label_text": "Multiple", "id": "s3358"}
{"text": " 5）年龄大于18岁，不大于75岁。", "label": 3, "label_text": "Age", "id": "s3359"}
{"text": " 【4】样本来源病例已收入过。", "label": 22, "label_text": "Data Accessible", "id": "s3360"}
{"text": " 2)有试验用药物（PEG-rhG-CSF任何成分或对聚乙二醇修饰的药物）、食物或其他物质过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3361"}
{"text": " （2）受试者知情，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3362"}
{"text": " 2.无影响机体PGE2代谢的其他慢性疾病，如心脏、肺部或肾脏疾病；", "label": 4, "label_text": "Disease", "id": "s3363"}
{"text": " 6有出血倾向的血液病患者。", "label": 5, "label_text": "Multiple", "id": "s3364"}
{"text": " (9)对本试验药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3365"}
{"text": "1.妊娠或哺乳妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3366"}
{"text": " 3．UICC 分期为Ⅱ期-Ⅳb期的鼻咽癌患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s3367"}
{"text": "(1)患者不配合或合并精神症状；", "label": 5, "label_text": "Multiple", "id": "s3368"}
{"text": " ⑤穿刺部位皮肤破损伴感染", "label": 4, "label_text": "Disease", "id": "s3369"}
{"text": " 3.取样及保存不当样本。", "label": 29, "label_text": "Receptor Status", "id": "s3370"}
{"text": " 3）术后非静脉PCA镇痛患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s3371"}
{"text": " 6）年龄18-45岁之间；", "label": 3, "label_text": "Age", "id": "s3372"}
{"text": " 愿意参加本研究，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3373"}
{"text": " -无法律行为能力者", "label": 17, "label_text": "Capacity", "id": "s3374"}
{"text": " ④病人不能合作或精神病患者。", "label": 5, "label_text": "Multiple", "id": "s3375"}
{"text": " 9. 有任何药物滥用史或药物成瘾史或在研究前药物检查中呈阳性；", "label": 2, "label_text": "Addictive Behavior", "id": "s3376"}
{"text": " 5.病程在24小时及以内；", "label": 4, "label_text": "Disease", "id": "s3377"}
{"text": " 4.妊娠或哺乳期妇女，或准备妊娠妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3378"}
{"text": "(1)结核及肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s3379"}
{"text": " 2.18-45岁的育龄女性", "label": 5, "label_text": "Multiple", "id": "s3380"}
{"text": " ②BMI&gt;=28kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s3381"}
{"text": " 3)具有以下颅内压升高的高危因素之一：", "label": 1, "label_text": "Sign", "id": "s3382"}
{"text": " 7、参与其他临床研究治疗", "label": 15, "label_text": "Enrollment in other studies", "id": "s3383"}
{"text": " ⑤ 研究者根据临床治疗经验及患者情况判断预计生存期少于半年；", "label": 23, "label_text": "Life Expectancy", "id": "s3384"}
{"text": "①患者合并有除COPD以外的其它呼吸系统疾病，如哮喘哮喘、间质性肺炎、活动性肺结核、社区获得性肺炎、肺癌、支气管扩张、肺心病、肺栓塞等；", "label": 4, "label_text": "Disease", "id": "s3385"}
{"text": " 10、严重精神疾病史，特别是抑郁症史；免疫性疾病史; 慢性肺病伴肺功能障碍史；严重心血管疾病史；甲状腺疾病未被有效治疗控制史", "label": 5, "label_text": "Multiple", "id": "s3386"}
{"text": " 7)  网织红细胞≥3%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3387"}
{"text": " 3）痉挛发作或以痉挛发作为主要发作类型；", "label": 4, "label_text": "Disease", "id": "s3388"}
{"text": "① 伴精神发育迟滞或脑器质性疾病；", "label": 4, "label_text": "Disease", "id": "s3389"}
{"text": " 17)在服用研究药物前24小时摄取了巧克力、任何含咖啡因或富含黄嘌呤食物或饮料。", "label": 18, "label_text": "Diet", "id": "s3390"}
{"text": "1）试验前3个月内每日吸烟量&gt;5支者；", "label": 36, "label_text": "Smoking Status", "id": "s3391"}
{"text": " 2、年龄18—75岁，术后1年内不准备生育者；", "label": 5, "label_text": "Multiple", "id": "s3392"}
{"text": " (4)合并其他严重疾病，如严重心肺疾病、血液病、自身免疫病等；", "label": 4, "label_text": "Disease", "id": "s3393"}
{"text": "① T4b期不可手术切除、多个淋巴结肿大（估计淋巴结转移≥3 个）、多站淋巴结肿大（估计淋巴结转移站数≥2 个）或有远处转移（M1）的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3394"}
{"text": "1.术后发生非计划再次手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3395"}
{"text": " 3.手术方式为肺叶切除；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3396"}
{"text": " 活动性或不能控制的感染", "label": 4, "label_text": "Disease", "id": "s3397"}
{"text": " ④不能获取大便样本；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3398"}
{"text": "1）首诊治疗为指南推荐的一线治疗外的治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3399"}
{"text": " (1)腹膜炎、肝硬化、低蛋白血症等非肿瘤原因引起的腹水；", "label": 5, "label_text": "Multiple", "id": "s3400"}
{"text": " 3.一般情况差，或并发其它疾病难以完成根治性治疗", "label": 5, "label_text": "Multiple", "id": "s3401"}
{"text": " 2）患有视网膜疾病，白内障，青光眼，糖尿病；", "label": 4, "label_text": "Disease", "id": "s3402"}
{"text": " （5）其它重要脏器功能不全。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3403"}
{"text": " 3.受试者能够理解研究目的，且应能配合临床随访，自愿参加临床试验，签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s3404"}
{"text": " 3、真菌镜检阳性者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3405"}
{"text": " 13) 心电图异常有临床意义或者男性QTCb&gt;470ms或者女性QTCb&gt;480ms。", "label": 5, "label_text": "Multiple", "id": "s3406"}
{"text": "（1）健康社区老年人", "label": 32, "label_text": "Healthy", "id": "s3407"}
{"text": " 5)ECOG 评分0～1；", "label": 9, "label_text": "Risk Assessment", "id": "s3408"}
{"text": " 1）年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s3409"}
{"text": " （2）脓毒症休克辩证为其他证型的患者，如腑实证、阴虚证等；", "label": 11, "label_text": "Diagnostic", "id": "s3410"}
{"text": " 2. 既往有肝病史或肝硬化病史，包括入院时已明确诊断和既往没有诊断的肝病史，病因包括乙肝、丙肝、酒精性肝病、原发性硬化性胆管炎等肝病）；", "label": 4, "label_text": "Disease", "id": "s3411"}
{"text": " （7）妊娠或哺乳期妇女，试验期间不能保证避孕的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3412"}
{"text": " f)患者对植入效果有正确预期，能够准时完成术后评估", "label": 17, "label_text": "Capacity", "id": "s3413"}
{"text": " （2）未使用过抗糖尿病药", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3414"}
{"text": " 6.既往眼内手术史和穿透性眼外伤史。", "label": 4, "label_text": "Disease", "id": "s3415"}
{"text": " ⑧VAS评分≥ 40 mm。", "label": 9, "label_text": "Risk Assessment", "id": "s3416"}
{"text": " 3)ASA分级II~III级；", "label": 9, "label_text": "Risk Assessment", "id": "s3417"}
{"text": "1）有血液系统疾病，出凝血功能障碍，近期使用抗凝药；", "label": 5, "label_text": "Multiple", "id": "s3418"}
{"text": " 2、结肠镜发现并经病理证实结肠恶性肿瘤或DALM的患者", "label": 11, "label_text": "Diagnostic", "id": "s3419"}
{"text": " 2.合并其他恶性肿瘤需要治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s3420"}
{"text": "①内分泌代谢科诊断明确的原发性肥胖患者，体重指数BMI ≥ 30kg/m2、有减重病史或肥胖相关合并症。", "label": 5, "label_text": "Multiple", "id": "s3421"}
{"text": "定期规律来中心进行体检的成年体检人群（健康体检人群）：", "label": 32, "label_text": "Healthy", "id": "s3422"}
{"text": " 6.目标病灶在6个月内接受过放射治疗者", "label": 5, "label_text": "Multiple", "id": "s3423"}
{"text": " 5）能理解研究目的，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3424"}
{"text": "1. 首诊患者，需经病理证实为喉鳞状细胞癌；", "label": 11, "label_text": "Diagnostic", "id": "s3425"}
{"text": " (8) 近3个月有重大手术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3426"}
{"text": " d.有斜视和/或弱视；", "label": 4, "label_text": "Disease", "id": "s3427"}
{"text": " 自愿参加本研究，并已经签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3428"}
{"text": " 2)发病前mRS评分≥2分；", "label": 9, "label_text": "Risk Assessment", "id": "s3429"}
{"text": " 4. 目前没有参加其他研究项目", "label": 15, "label_text": "Enrollment in other studies", "id": "s3430"}
{"text": " ?患者的依从性满足随访的需要。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3431"}
{"text": " 4) 酗酒或吸毒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3432"}
{"text": " 2)既往接受过肾移植或其它器官移植的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3433"}
{"text": " 4.入组前6个月内未接受过抗病毒治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3434"}
{"text": " 15)语言交流障碍", "label": 25, "label_text": "Literacy", "id": "s3435"}
{"text": " 6  肝、肾功能结果正常或基本正常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3436"}
{"text": "①　符合膝骨关节炎诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s3437"}
{"text": " 8)HIV检测阳性者或RPR检测阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3438"}
{"text": " 6.针刺操作可在发病后72小时内进行者；", "label": 5, "label_text": "Multiple", "id": "s3439"}
{"text": " 4.正在参加其他体重控制项目，或进行减肥治疗者不建议参加；", "label": 5, "label_text": "Multiple", "id": "s3440"}
{"text": " 14) 研究者本人和研究中心相关人员及其家庭成员。", "label": 26, "label_text": "Encounter", "id": "s3441"}
{"text": " 6.不能耐受双联抗血小板及他汀治疗者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3442"}
{"text": " c.已行子宫全切术或宫颈切除术的女性；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3443"}
{"text": " 4、由以下原因引起精浆变异患者，如附睾、精囊、前列腺等有炎症时，酸碱度、供氧、营养、代谢等均不利于精子的活动和存活或精液中的白细胞数量大于100万/ml；", "label": 5, "label_text": "Multiple", "id": "s3444"}
{"text": " 7.能遵从简单口头指令；", "label": 17, "label_text": "Capacity", "id": "s3445"}
{"text": " （11）不能配合麻醉医生和外科医生的要求，有精神疾病者；", "label": 5, "label_text": "Multiple", "id": "s3446"}
{"text": " 8)在服用研究药物前14 天内服用了任何处方药、非处方药、任何维生素产品或草药。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3447"}
{"text": " 3）同意参加本研究，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s3448"}
{"text": " 3、曾发生糖尿病急性并发症（糖尿病酮症酸中毒、高血糖高渗综合征、糖尿病乳酸性酸中毒）；", "label": 4, "label_text": "Disease", "id": "s3449"}
{"text": "①符合第四届脑血管会议制定的诊断标准，并经头颅CT或MRI检查证实；", "label": 11, "label_text": "Diagnostic", "id": "s3450"}
{"text": " d)病理提示有卫星灶或子灶；", "label": 4, "label_text": "Disease", "id": "s3451"}
{"text": " 11)研究者认为不适合参加本次试验者", "label": 21, "label_text": "Researcher Decision", "id": "s3452"}
{"text": "（1）年龄18~60岁；", "label": 3, "label_text": "Age", "id": "s3453"}
{"text": " 2、测前1周内进行小腿牵拉、按摩等操作者。", "label": 27, "label_text": "Exercise", "id": "s3454"}
{"text": " 2.孕妇、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3455"}
{"text": " 4.在参加研究期间需合并使用影响胃肠动力及影响阿米替林作用的药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3456"}
{"text": " （8）有吸毒史或酗酒史者。", "label": 2, "label_text": "Addictive Behavior", "id": "s3457"}
{"text": " 4.严重肝功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3458"}
{"text": " 4)心脏射血分数≥50%，超声心动图检查确认未见心包积液，未见有临床意义的心电图发现；不存在有临床意义的胸腔；在室内时基线血氧饱和度&gt;92%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3459"}
{"text": " ②年龄18～60岁,伤前无明显重要脏器器质性病变。", "label": 5, "label_text": "Multiple", "id": "s3460"}
{"text": " 8. 试验前2周内用过任何药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3461"}
{"text": " （4）由银汞合金充填体或其他刺激物引起的苔藓样反应者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3462"}
{"text": " 8．术中死亡者", "label": 0, "label_text": "Therapy or Surgery", "id": "s3463"}
{"text": " ③ 放疗不敏感的鼻咽恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s3464"}
{"text": " （4）入组之前14天内血常规满足：Hb≥80g/L，ANC≥1.0×109/L，PLT≥75×109/L；肝肾功能满足：TBIL≤1.5×ULN，ALT、AST≤ 2.0×ULN、Cr ≤1.5×ULN；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3465"}
{"text": " （2）入院前规律服用利尿剂；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3466"}
{"text": " 9、严重或难以控制的感染。", "label": 4, "label_text": "Disease", "id": "s3467"}
{"text": " 3.转移性肾细胞癌，具有至少一个RECIST 1.1标准或骨转移病灶MDA标准可评价的转移病灶，且符合以下入组条件：", "label": 11, "label_text": "Diagnostic", "id": "s3468"}
{"text": " （3）深夜血浆皮质醇＞50 nmol/L（1.8 mg/dL）；如≤1.8 mg/ dL，可排除CS", "label": 12, "label_text": "Laboratory Examinations", "id": "s3469"}
{"text": " (5) 正在参与其他药物临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3470"}
{"text": " 4.病理分级为中度及以上慢性萎缩性胃炎患者；", "label": 4, "label_text": "Disease", "id": "s3471"}
{"text": " 3.严重营养不良、佝偻病患者及合并心、脑、肝、肾及造血等系统严重原发性疾病者；其中AST、ALT＞1.5N(N为正常值上限)者；BUN、Cr＞1.2N(N为正常值上限)者；", "label": 5, "label_text": "Multiple", "id": "s3472"}
{"text": " （3）泪小管断裂吻合术后泪道冲洗通畅", "label": 0, "label_text": "Therapy or Surgery", "id": "s3473"}
{"text": " 3.经临床医生判断，患者可诊断AUB-O。", "label": 11, "label_text": "Diagnostic", "id": "s3474"}
{"text": " 3.患者无保留生育能力的需求", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3475"}
{"text": " 3）存在髓外浸润或中枢神经系统浸润的患者", "label": 4, "label_text": "Disease", "id": "s3476"}
{"text": " 3.任何时候接受过阿扎胞苷或地西他滨的治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3477"}
{"text": " -先前接受或没有接受过传统青光眼手术失败史(小梁切除术)的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s3478"}
{"text": "(1)符合NASH西医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3479"}
{"text": " 4.既往有癫痫病史。", "label": 4, "label_text": "Disease", "id": "s3480"}
{"text": " （3）患侧直腿抬高试验小于 50° ；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3481"}
{"text": " 1.12严重神经或精神病史；严重感染；活动性的播散性血管内凝血或其它根据研究者的判断，严重危害患者安全或影响患者完成研究的伴随疾病。", "label": 5, "label_text": "Multiple", "id": "s3482"}
{"text": " 造影相关：", "label": 12, "label_text": "Laboratory Examinations", "id": "s3483"}
{"text": " 2 .BMI≥24kg/m2，腰围（WC）≥80cm的超重或肥胖患者；", "label": 5, "label_text": "Multiple", "id": "s3484"}
{"text": " (3) 哺乳期未服用DHA补充剂，无特殊偏食习惯；", "label": 5, "label_text": "Multiple", "id": "s3485"}
{"text": " 8. 预期生存期&gt;3个月。", "label": 23, "label_text": "Life Expectancy", "id": "s3486"}
{"text": " （8）卒中后严重残疾，基线时MRS评分&gt;4分的患者；", "label": 5, "label_text": "Multiple", "id": "s3487"}
{"text": " 存在手足皮肤病变不能接受中药外洗者。", "label": 5, "label_text": "Multiple", "id": "s3488"}
{"text": " 4、自愿参与此项临床研究，研究开始前患者签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s3489"}
{"text": " 2. 合并严重的心、肝、肺、肾、血液、内分泌、神经系统疾病及自身免疫疾病", "label": 4, "label_text": "Disease", "id": "s3490"}
{"text": " （6）活动性出血者", "label": 1, "label_text": "Sign", "id": "s3491"}
{"text": "（1）患者存在使用比伐芦定的禁忌", "label": 4, "label_text": "Disease", "id": "s3492"}
{"text": " 2.年龄40～80周岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s3493"}
{"text": " 3、40岁≤年龄≤80岁；", "label": 3, "label_text": "Age", "id": "s3494"}
{"text": "1、年龄18-80", "label": 3, "label_text": "Age", "id": "s3495"}
{"text": "1.年龄18-70岁的择期拟行腹腔镜下妇科恶性肿瘤根治手术患者", "label": 5, "label_text": "Multiple", "id": "s3496"}
{"text": " 3.能够与研究者良好交流及遵照整个试验要求。", "label": 5, "label_text": "Multiple", "id": "s3497"}
{"text": " 5)入选前4周检查便潜血阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3498"}
{"text": " 11.18岁以下或60岁以上患者（含18岁与60岁）", "label": 3, "label_text": "Age", "id": "s3499"}
{"text": " (11)控制不良的其他重要脏器原发疾病如神经系统、心血管系统、泌尿系统、消化系统、呼吸系统、代谢及骨骼肌肉系统的明确病史（如控制不良的糖尿病、高血压等），使研究者认为不适合参加者；", "label": 5, "label_text": "Multiple", "id": "s3500"}
{"text": " 6.合并恶性肿瘤者，尤其是消化道肿瘤患者,", "label": 4, "label_text": "Disease", "id": "s3501"}
{"text": "1 明确诊断的恶性肿瘤者；", "label": 4, "label_text": "Disease", "id": "s3502"}
{"text": "1.年龄18-60岁；", "label": 3, "label_text": "Age", "id": "s3503"}
{"text": " （7）患有严重免疫系统损伤性疾病（如淋巴瘤、ADIS、Wiskott-Aldrich综合征）或有恶性肿瘤病史者；", "label": 4, "label_text": "Disease", "id": "s3504"}
{"text": " 5）无法或不愿意接受叶酸、维生素B12补充，或服用地塞米松。", "label": 13, "label_text": "Consent", "id": "s3505"}
{"text": " 3)4个月内针对前列腺癌转移病灶进行放疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3506"}
{"text": " （5）签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3507"}
{"text": " 4) 无过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3508"}
{"text": " ⑤签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3509"}
{"text": "(1)测试时发作急性病如急性肺炎、发热、严重感冒、急性胃穿孔等。", "label": 4, "label_text": "Disease", "id": "s3510"}
{"text": " （2）年龄在18-80岁；", "label": 3, "label_text": "Age", "id": "s3511"}
{"text": "   3）KPS评分≥70分；", "label": 9, "label_text": "Risk Assessment", "id": "s3512"}
{"text": " 19) 研究者认为不适合入组的其他患者，如工作环境经常变动、生活环境不稳定等；", "label": 21, "label_text": "Researcher Decision", "id": "s3513"}
{"text": " 8)严重肥胖", "label": 4, "label_text": "Disease", "id": "s3514"}
{"text": " （4）正在参加其他药物临床试验者或1个月内参加过其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3515"}
{"text": "（1）签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s3516"}
{"text": "-男性，年龄30-60岁", "label": 5, "label_text": "Multiple", "id": "s3517"}
{"text": "1.有全身系统性疾病者。", "label": 4, "label_text": "Disease", "id": "s3518"}
{"text": "(1)符合西医及中医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3519"}
{"text": " 4）签署知情同意", "label": 13, "label_text": "Consent", "id": "s3520"}
{"text": " 6. 依从性差。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3521"}
{"text": " 8.妊娠或哺乳期的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3522"}
{"text": " （4）糖尿病患者。", "label": 4, "label_text": "Disease", "id": "s3523"}
{"text": " 7.3个月内参加其他临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3524"}
{"text": " 5)无严重感染；", "label": 4, "label_text": "Disease", "id": "s3525"}
{"text": "a) 年龄18-70岁，男女不限", "label": 5, "label_text": "Multiple", "id": "s3526"}
{"text": " 4.试验前两周内未服用任何其它药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3527"}
{"text": "1.年龄6-60岁；", "label": 3, "label_text": "Age", "id": "s3528"}
{"text": " 2）年龄&gt;=18岁，性别不限", "label": 5, "label_text": "Multiple", "id": "s3529"}
{"text": " 5.脑肿瘤、脑外伤、恶性肿瘤、血液病、肝功能障碍（转氨酶超过正常值上限2倍）、肾功能障碍（肌酐值超过正常值上限1.5倍）或患有其它严重全身性疾病，预期寿命≤3个月者；", "label": 5, "label_text": "Multiple", "id": "s3530"}
{"text": " 6、年龄在18-75岁；", "label": 3, "label_text": "Age", "id": "s3531"}
{"text": " 既往使用细胞刺激因子的，在入组一个月前停止细胞因子治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3532"}
{"text": " 2.本人及家属签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3533"}
{"text": " （6）筛选前30 天内参加了其他的药物或医疗器械临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3534"}
{"text": " 3.嗜烟、嗜酒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3535"}
{"text": " 有明显胃肠道损害的病史，研究者判断可能会显著影响替吉奥的吸收，包括对整体药品的吞咽能力；", "label": 5, "label_text": "Multiple", "id": "s3536"}
{"text": " (8)能与研究者良好沟通，遵从整个研究的要求。", "label": 25, "label_text": "Literacy", "id": "s3537"}
{"text": " D．患者有保乳意愿，且病情允许并计划进行保乳手术；", "label": 5, "label_text": "Multiple", "id": "s3538"}
{"text": " ●近三周内可能行肝移植手术或已经行肝移植手术者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3539"}
{"text": " (2) 有症状的脑转移。", "label": 24, "label_text": "Neoplasm Status", "id": "s3540"}
{"text": " ②合并血液系统疾病、自身免疫性疾病、恶性肿瘤等其他系统急慢性疾病者；", "label": 4, "label_text": "Disease", "id": "s3541"}
{"text": " 5.肝功能范围：胆红素≤2倍正常值上限，AST和ALT≤2倍正常值上限；肾功能：Cr ≤1.25倍正常值上限，BUN≤1.25倍正常值上限；", "label": 5, "label_text": "Multiple", "id": "s3542"}
{"text": " 8.足够的肾功能：血清肌酐≤正常值上限(ULN)或者计算的肌酐清除率≥50 mL/min", "label": 5, "label_text": "Multiple", "id": "s3543"}
{"text": " 1.当前或过去诊断过双相障碍的患者；", "label": 11, "label_text": "Diagnostic", "id": "s3544"}
{"text": " 3.能够通过手术取得新鲜的肿瘤组织样本；", "label": 29, "label_text": "Receptor Status", "id": "s3545"}
{"text": " 3.活动性乙肝或丙肝患者，乙肝病毒携带者；", "label": 4, "label_text": "Disease", "id": "s3546"}
{"text": " （2）合并帕金森病、肝豆状核变性及其它引起不自主运动的疾病；", "label": 4, "label_text": "Disease", "id": "s3547"}
{"text": " 3，患儿、监护人不能接受或配合手术；或合并其他原因无法耐受手术治疗", "label": 5, "label_text": "Multiple", "id": "s3548"}
{"text": " D、 人类免疫缺陷病毒(HIV) 感染；", "label": 4, "label_text": "Disease", "id": "s3549"}
{"text": " 5.拒绝接受相关治疗方案或随访方案；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3550"}
{"text": "1. 严重疾病导致后期随访困难，或任何调查员判断不能接受随访的情况；", "label": 5, "label_text": "Multiple", "id": "s3551"}
{"text": " 12）既往对同类药物不耐受或过敏史", "label": 7, "label_text": "Allergy Intolerance", "id": "s3552"}
{"text": " 3无激光治疗禁忌症；", "label": 4, "label_text": "Disease", "id": "s3553"}
{"text": " ?绝育术（男伴双侧输精管结扎术、切除术）", "label": 0, "label_text": "Therapy or Surgery", "id": "s3554"}
{"text": "（1）妊娠期、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3555"}
{"text": " 6) 精神疾病患者。", "label": 4, "label_text": "Disease", "id": "s3556"}
{"text": " 2、既往无明确原发性高血压病史，且近4周未服用抗高血压药；一周内非同日连续3次测量右上肢肱动脉坐位收缩压在130~139mmhg,和/坐位舒张压85~89mmhg。", "label": 5, "label_text": "Multiple", "id": "s3557"}
{"text": " （2）既往精神疾病史。", "label": 4, "label_text": "Disease", "id": "s3558"}
{"text": " （5）所有病例必须为进展期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s3559"}
{"text": " 7) 自愿签署知情同意书。 自愿签署知情同意书。 自愿签署知情同意书。 自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3560"}
{"text": "1）中途退出者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3561"}
{"text": " 1)结节性淋巴细胞为主型霍奇金淋巴瘤或灰区淋巴瘤；", "label": 4, "label_text": "Disease", "id": "s3562"}
{"text": " 2.年龄18～80岁。", "label": 3, "label_text": "Age", "id": "s3563"}
{"text": " 3、严重心衰患者，EF&lt;35%；", "label": 5, "label_text": "Multiple", "id": "s3564"}
{"text": " 2.既往存在VTE或静脉曲张、静脉炎等血管疾病", "label": 4, "label_text": "Disease", "id": "s3565"}
{"text": " 合并有精神障碍的患者；", "label": 4, "label_text": "Disease", "id": "s3566"}
{"text": " 5. 家长同意并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3567"}
{"text": " 11、其他任何情况，研究者认为不适宜参加本项目者。", "label": 21, "label_text": "Researcher Decision", "id": "s3568"}
{"text": " 26.根据研究者的判断，属于除入选标准和排除标准以外的因其它任何原因而不适合参加本研究的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s3569"}
{"text": " 4.肝肾功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3570"}
{"text": "1. 年龄≤35周岁的不孕妇女；", "label": 5, "label_text": "Multiple", "id": "s3571"}
{"text": " ?总胆红素≥40 μmol/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s3572"}
{"text": " 5.完全自愿地签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3573"}
{"text": " 6)白细胞和/或血小板减少者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3574"}
{"text": " 6.女性在月经期间者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3575"}
{"text": " 2、符合肾结石标准，且穿刺目标肾盏无扩张或轻度扩张，", "label": 5, "label_text": "Multiple", "id": "s3576"}
{"text": " 8.在过去4周内发生过可能会影响血糖控制的急性感染。", "label": 4, "label_text": "Disease", "id": "s3577"}
{"text": " 5 年龄18-70岁之间。", "label": 3, "label_text": "Age", "id": "s3578"}
{"text": " 3. 出血高危患者；", "label": 4, "label_text": "Disease", "id": "s3579"}
{"text": " 4)3个月内参加过其他临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s3580"}
{"text": "1.根据盆腔器官脱垂分度（POP-Q）诊断为III-IV度的患者", "label": 11, "label_text": "Diagnostic", "id": "s3581"}
{"text": " 4.合并有严重的肺、心、肝功能不全者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3582"}
{"text": " 病史及查体：存在软组织缺损的问题。如果是乳房缺损的患者，要求结束肿瘤化疗放疗治疗结束之后。", "label": 5, "label_text": "Multiple", "id": "s3583"}
{"text": " 已知对肝素、造影剂、紫杉醇、碘普罗胺、雷帕霉素、聚乳酸-羟基乙酸聚合物、不锈钢等不能耐受或过敏的受试者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3584"}
{"text": " （3）患者自愿并有能力接受抗VEGF药物（康柏西普）治疗。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3585"}
{"text": "1.年龄60-75岁的老年患者，性别不限;", "label": 5, "label_text": "Multiple", "id": "s3586"}
{"text": " 8.尿常规提示尿蛋白≥ ++，或证实24小时尿蛋白量≥1.0 g；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3587"}
{"text": " 3、合并严重的心、肺、脑和精神病等严重原发病；", "label": 4, "label_text": "Disease", "id": "s3588"}
{"text": " 6)随访前的4周内患者接受过大的外科手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s3589"}
{"text": " 5.有严重影响药物吸收的胃肠疾患者；", "label": 4, "label_text": "Disease", "id": "s3590"}
{"text": " 2. 预计生存年限&lt;1年", "label": 23, "label_text": "Life Expectancy", "id": "s3591"}
{"text": "1）18-45周岁（包括边界值）的男性健康受试者；", "label": 5, "label_text": "Multiple", "id": "s3592"}
{"text": " （4）因风湿性心脏病、冠心病及其他心脏病合并房颤，引起脑栓塞者；", "label": 4, "label_text": "Disease", "id": "s3593"}
{"text": " 如果出现以下（1）至（3）不良事件（AE）之一者，禁止继续接种疫苗，但可以根据研究者判断继续其它研究步骤；如果出现以下（4）至（5）不良事件之一者，由研究者判断是否继续接种；如果出现以下（6）至（7）不良事件之一者，可在方案规定的时间窗内推迟接种（不出现（6）至（7）不良事件情况下第二针接种是在第28天，推迟时间窗内推迟接种是指在28天后3天内接种）。以下AE，受试者必须被随访至事件解决。", "label": 5, "label_text": "Multiple", "id": "s3594"}
{"text": " (4)需要青霉素类、头孢类的抗生素治疗，治疗疗程为7-14天、单用与联合应用其他抗菌药物不限", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3595"}
{"text": "1）急性心肌梗死或其他原因引起的急性左心衰竭；", "label": 4, "label_text": "Disease", "id": "s3596"}
{"text": " 6、肝功显著异常或有下列肝病病史：AST或ALT高于正常值上限的2 倍，肝性脑病史，食管静脉曲张史或门脉分流史；", "label": 5, "label_text": "Multiple", "id": "s3597"}
{"text": " 6、患有慢性传染性疾病，如肺结核、病毒性肝炎等；", "label": 4, "label_text": "Disease", "id": "s3598"}
{"text": " （2）病人被诊断为丙肝肝癌并且术前未做过任何抗肿瘤治疗，丙肝肝癌的诊断主要通过超声、电子计算机X射线断层成像或者是磁共振成像以及生化指标（血清学甲胎蛋白、肝功各项指标），确诊主要通过组织病理学诊断，诊断标准符合美国肝病研究协会诊断指南。", "label": 5, "label_text": "Multiple", "id": "s3599"}
{"text": " C ATC术后患者，或行辅助治疗（辅助放疗，化疗）后的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s3600"}
{"text": "（1）年龄≥50岁，≤85岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s3601"}
{"text": " 2.存在肝外其他转移灶", "label": 4, "label_text": "Disease", "id": "s3602"}
{"text": " 14)  酗酒、吸毒或药物成瘾者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3603"}
{"text": " ⑥签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3604"}
{"text": " ④ 合并严重或不稳定的躯体疾病。", "label": 4, "label_text": "Disease", "id": "s3605"}
{"text": " 2)具有研究涉及药物禁忌证，包括已知或怀疑对研究涉及药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3606"}
{"text": " 2性别不限，18≤年龄≤34；", "label": 5, "label_text": "Multiple", "id": "s3607"}
{"text": " 4、血清ast/alt大于正常值上限的3倍；肌酐大于正常值上限的1.5倍；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3608"}
{"text": "①不符合FAP诊断标准者。", "label": 11, "label_text": "Diagnostic", "id": "s3609"}
{"text": " 4、签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3610"}
{"text": " 10，所有入组患者术前均签订知情同意书。在术前谈话中您将被明确告知：不同重建术式的基本情况和应用现状；研究目的和研究意义；研究对象的义务和权利；具体手术方式以信封法决定。须特别指出您术后将不被告知其所采用的重建方式。", "label": 13, "label_text": "Consent", "id": "s3611"}
{"text": " 手术时间≥2小时的非心脏、非神经外科手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s3612"}
{"text": " （5）估计患者依从性较差，不易随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3613"}
{"text": " ③年龄25-70岁；", "label": 3, "label_text": "Age", "id": "s3614"}
{"text": " 12)中性粒细胞绝对值 ≥1,200/mm3(1.2×109/L)；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3615"}
{"text": " 8. 筛选前6个月内至少有一次血清ALT水平在正常值上限（ULN）的2－10倍之间，并且在筛选时血清1.5×ULN≤ALT≤10×ULN；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3616"}
{"text": " 4）高血压、糖尿病，药物控制效果不佳者。", "label": 4, "label_text": "Disease", "id": "s3617"}
{"text": " d)伴有其他恶性疾病", "label": 4, "label_text": "Disease", "id": "s3618"}
{"text": " 3.可配合行认知功能评估的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3619"}
{"text": " ④总胆红素≥50umol/L或慢加急性肝衰竭（PTA≤40%，或总胆红素每日升高≥17.1umol/L）；⑤血清白蛋白低于25g/L。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3620"}
{"text": " –谷丙转氨酶、谷草转氨酶、碱性磷酸酶≤2.5倍正常值上限；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3621"}
{"text": "1、已知对本研究的药物成分过敏及过敏体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3622"}
{"text": " 2. 急性早幼粒细胞白血病(M3型)", "label": 4, "label_text": "Disease", "id": "s3623"}
{"text": " 4．术前声音嘶哑，术前鼻腔畸形", "label": 4, "label_text": "Disease", "id": "s3624"}
{"text": "(1)有胃、脾、肝、肾等慢性病史、其它严重疾病史、或体格检查时发现有不宜参加试验的疾病", "label": 4, "label_text": "Disease", "id": "s3625"}
{"text": " 5.年龄在18—65岁之间（含18岁与65岁）；", "label": 3, "label_text": "Age", "id": "s3626"}
{"text": " 2 稳定的代谢控制：每个月的hba1c水平与基线时比较变异≤10%，持续3个月以上；血压控制&lt;160/90mmhg至少6个月；", "label": 5, "label_text": "Multiple", "id": "s3627"}
{"text": " 2、无严重的心血管疾病、肿瘤和不能用药物控制的其他疾病；", "label": 4, "label_text": "Disease", "id": "s3628"}
{"text": " 5. 体重指数(BMI)&gt;35 kg/m2", "label": 9, "label_text": "Risk Assessment", "id": "s3629"}
{"text": " 3.自愿加入本研究，签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s3630"}
{"text": " c.已行子宫全切术或宫颈切除术的女性；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3631"}
{"text": " h)有膏方、穴位贴敷、茶饮的禁忌症者；", "label": 4, "label_text": "Disease", "id": "s3632"}
{"text": "</bmi<28.0kg>", "label": 12, "label_text": "Laboratory Examinations", "id": "s3633"}
{"text": " （11）炎症性肠道疾病或糖尿病胃轻瘫。", "label": 4, "label_text": "Disease", "id": "s3634"}
{"text": " 2.有任何可能影响治疗及检查结果的局部或者全身疾病;", "label": 4, "label_text": "Disease", "id": "s3635"}
{"text": " 6.出于任何原因不能配合研究，如语言障碍，精神疾病等。", "label": 5, "label_text": "Multiple", "id": "s3636"}
{"text": " 5. 能够且愿意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3637"}
{"text": "①ASAⅠ～Ⅱ级,年龄18~45岁", "label": 5, "label_text": "Multiple", "id": "s3638"}
{"text": " 6)体格检查、生命体征正常或异常无临床意义。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3639"}
{"text": " 4.至少有一个可测量病灶（根据RECIST 1.1标准，肿瘤病灶CT扫描长径≥10mm，淋巴结病灶CT扫描短径≥15mm）；", "label": 5, "label_text": "Multiple", "id": "s3640"}
{"text": "1.影像学检查发现淋巴结转移。", "label": 4, "label_text": "Disease", "id": "s3641"}
{"text": "1. 由其他疾病如遗传、内分泌、代谢及中枢神经系统疾病引起的肥胖及肥胖综合征；", "label": 4, "label_text": "Disease", "id": "s3642"}
{"text": " 9)精神病患者或其它原因不能依从治疗；", "label": 5, "label_text": "Multiple", "id": "s3643"}
{"text": " （3）冠脉造影显示：单支或多支血管包括前降支、回旋支、右冠脉（含主要分支血管，分支直径须≥2.25mm），CAG狭窄超过50%。由两名独立术者判断至少一处病变需要PCI者", "label": 5, "label_text": "Multiple", "id": "s3644"}
{"text": " 6) 患者本人或其法律监护人签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3645"}
{"text": " （4）除肝移植外，还需一同进行其他操作者（如肾移植）。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3646"}
{"text": " 13、宫颈组织活检提示CIN I级及以上者", "label": 11, "label_text": "Diagnostic", "id": "s3647"}
{"text": " (6)已知发生中枢神经系统转移的患者；", "label": 24, "label_text": "Neoplasm Status", "id": "s3648"}
{"text": " （4）签署知情同意书，自愿受试。获得知情同意书过程应符合GCP规定。", "label": 13, "label_text": "Consent", "id": "s3649"}
{"text": " 5)胃镜检查前12周服用过抗生素、铋剂和中成药等药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3650"}
{"text": " 2：急性出血者；", "label": 1, "label_text": "Sign", "id": "s3651"}
{"text": " 5、为右利手", "label": 19, "label_text": "Special Patient Characteristic", "id": "s3652"}
{"text": " 4)身体健康：全身体格检查正常；实验室血常规、肝功能、肾功能检查正常。", "label": 32, "label_text": "Healthy", "id": "s3653"}
{"text": " (5)肾功能异常者，SCr&gt;1.2mg/dl；", "label": 5, "label_text": "Multiple", "id": "s3654"}
{"text": " （5）已知对治疗药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3655"}
{"text": " 4、已伴有严重糖尿病相关性疾病（糖尿病足病、视网膜病变、伴临床症状和/或体征的周围血管病变、心脑血管疾病、肾病、糖尿病心脏自主神经病变）；", "label": 4, "label_text": "Disease", "id": "s3656"}
{"text": "1.研究者详细介绍并使受试者充分了解试验内容，受试者自愿参加试验，并签署知情同意书或家属代签知情同意；", "label": 13, "label_text": "Consent", "id": "s3657"}
{"text": " ③4周内无呼吸系统感染及COPD的急性加重；", "label": 4, "label_text": "Disease", "id": "s3658"}
{"text": " 7、患者了解研究的目的和要求并且知情同意。", "label": 13, "label_text": "Consent", "id": "s3659"}
{"text": " （4）子宫、宫颈或附件肿瘤。", "label": 4, "label_text": "Disease", "id": "s3660"}
{"text": " ④严重心、脑、肺、肝、肾疾病者；", "label": 4, "label_text": "Disease", "id": "s3661"}
{"text": " 6.有酒精、药物依赖史的患者。", "label": 2, "label_text": "Addictive Behavior", "id": "s3662"}
{"text": " 2）知情同意书签署前已经诊断为ITP至少12个月（慢性ITP标准）的病人；", "label": 4, "label_text": "Disease", "id": "s3663"}
{"text": " 4.患者既往曾记录有脑转移、软脑膜病变或未得到控制的脊髓压迫", "label": 4, "label_text": "Disease", "id": "s3664"}
{"text": " 入组前血流动力学平稳，收缩压&gt; 110 mm Hg，舒张压&gt; 60 mm Hg，心率&lt;120次/分钟；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3665"}
{"text": " （14）发生过心肌梗塞或中风，及充血性心力衰竭患者；", "label": 4, "label_text": "Disease", "id": "s3666"}
{"text": " 11、器官移植需要免疫抑制治疗者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3667"}
{"text": " 8. 受试者须阅读并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3668"}
{"text": " 3) BMI18～30kg.m-2；", "label": 9, "label_text": "Risk Assessment", "id": "s3669"}
{"text": " 2） 惰性B细胞淋巴瘤（CLL、FL、MZL、LPL）；", "label": 4, "label_text": "Disease", "id": "s3670"}
{"text": " 2. 孕期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3671"}
{"text": " 8.患者对于研究中使用的药物过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s3672"}
{"text": " ③根据病情需要使用抗生素哌拉西林他唑巴坦", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3673"}
{"text": " 6 拒绝做磁共振检查者。", "label": 13, "label_text": "Consent", "id": "s3674"}
{"text": " ? 初治患者，本次发病患者未接受过TACE 和索拉非尼等抗肝癌治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3675"}
{"text": " 5、患有影响运动完成或运动可使其加重的疾病（如感染、电解质紊乱、未控制的甲状腺功能亢进、未控制的高血压收缩压＞160mmHg和/或舒张压＞100mmHg等）；", "label": 4, "label_text": "Disease", "id": "s3676"}
{"text": " （2）发病24小时内死亡", "label": 4, "label_text": "Disease", "id": "s3677"}
{"text": " 曾接受过实体器官移植，除了原位肝脏移植；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3678"}
{"text": "1.年龄≥60岁", "label": 3, "label_text": "Age", "id": "s3679"}
{"text": " ⅲ3个月内服用抗生素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3680"}
{"text": " 5.生活或工作环境不适宜配戴接触镜，例如空气中弥散粉尘、药品、气雾剂（如发胶、挥发性化学物）、灰尘等；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s3681"}
{"text": " (3)由于其他非椎间盘突出原因引起的腿痛、麻木或无力者。", "label": 28, "label_text": "Symptom", "id": "s3682"}
{"text": " 4. 既往未行任何针对肿瘤的治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3683"}
{"text": " 4.受试者愿意并且有能力依从与研究访视安排，实验室检查以及其他研究程序。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3684"}
{"text": " ? OA（骨关节炎）, RA（类风湿 性关节炎）", "label": 4, "label_text": "Disease", "id": "s3685"}
{"text": " ⑸2型糖尿病；", "label": 4, "label_text": "Disease", "id": "s3686"}
{"text": " *患者年龄 &gt;= 65岁;", "label": 3, "label_text": "Age", "id": "s3687"}
{"text": " d.患有严重的心肝肾等疾病（如先天性心脏病、慢性肝炎、肾病综合征、急性肾小球肾炎等）；", "label": 4, "label_text": "Disease", "id": "s3688"}
{"text": " ⑧过敏体质及对多种药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3689"}
{"text": " 13.研究者认为不适合参加本临床研究的受试者。", "label": 21, "label_text": "Researcher Decision", "id": "s3690"}
{"text": " ②符合肾病综合征诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3691"}
{"text": " 4.屈光参差&lt;1.50D", "label": 12, "label_text": "Laboratory Examinations", "id": "s3692"}
{"text": " 12.痴呆、智力异常或任何妨碍对知情同意书理解的精神疾病。", "label": 4, "label_text": "Disease", "id": "s3693"}
{"text": "1. 18-65岁肾移植患者、HIV感染者或膀胱癌患者；", "label": 5, "label_text": "Multiple", "id": "s3694"}
{"text": " ⑷：凝血功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3695"}
{"text": " 8)接种过抗肿瘤疫苗者，或筛选前4周内曾接受过具有免疫刺激作用的抗肿瘤药治疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3696"}
{"text": "1.CKD2-4期（eGFR：15～90 ml/min/1.73m2）；", "label": 5, "label_text": "Multiple", "id": "s3697"}
{"text": "按个人剔除标准，即社区中心内医护人员为剔除对象，", "label": 26, "label_text": "Encounter", "id": "s3698"}
{"text": " 2.接受过针对BCR/ABL融合基因的小分子靶向药物（达沙替尼、达沙替尼和尼龙替尼）治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3699"}
{"text": " - 膝关节MRI确诊半月板损伤，按 Stoller分级II级和III级", "label": 5, "label_text": "Multiple", "id": "s3700"}
{"text": " （7）愿意参加本临床研究并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3701"}
{"text": "（1）脊柱不稳定、有椎管狭窄、脊椎滑脱、脊椎前移、脊柱侧凸等腰椎疾患；", "label": 4, "label_text": "Disease", "id": "s3702"}
{"text": " m)不同意签署知情同意书者（包括但不限于供者知情同意书、受试者知情同意书、手术知情同意书）。", "label": 13, "label_text": "Consent", "id": "s3703"}
{"text": " 5.实验室检查肝肾功能正常者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3704"}
{"text": " c．房角镜检查发现窄房角的基础上房角粘连超过1/2周；", "label": 11, "label_text": "Diagnostic", "id": "s3705"}
{"text": "1）试验前签署知情同意书、并对试验内容、过程及可能出现的不良反应充分了解；", "label": 13, "label_text": "Consent", "id": "s3706"}
{"text": "1、患者食管局部梗阻非肿瘤进展所致；", "label": 4, "label_text": "Disease", "id": "s3707"}
{"text": " 8)孕妇或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3708"}
{"text": " 6. 近半年内接受过雌激素替代治疗的绝经后女性。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3709"}
{"text": " （2）哺乳期或怀孕妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3710"}
{"text": " 5)初治或有子宫出血的子宫颈癌患者；", "label": 4, "label_text": "Disease", "id": "s3711"}
{"text": " ?呼吸频率≥20次/分或PaCO2≤32mmHg或需要机械通气", "label": 12, "label_text": "Laboratory Examinations", "id": "s3712"}
{"text": "1、居住流动性大，不易定期随访者", "label": 8, "label_text": "Compliance with Protocol", "id": "s3713"}
{"text": " 11，恶性肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s3714"}
{"text": " （7）正在参加其他药物临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3715"}
{"text": " 2、无全视网膜光凝术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3716"}
{"text": "①明确的失代偿性肝硬化；原发性/转移性肝癌；自身免疫性肝病；药物性肝病；酒精性肝病；中毒性肝损伤。", "label": 4, "label_text": "Disease", "id": "s3717"}
{"text": " h)在以前皮肤损伤区域有瘢痕疙瘩形成或创伤愈合不良的病史。", "label": 4, "label_text": "Disease", "id": "s3718"}
{"text": " 3) 活动期中重度甲状腺相关眼病；", "label": 4, "label_text": "Disease", "id": "s3719"}
{"text": " 2)严格肝移植术前评估，存在肝移植手术禁忌症；", "label": 5, "label_text": "Multiple", "id": "s3720"}
{"text": " （6）神经内分泌功能异常;", "label": 4, "label_text": "Disease", "id": "s3721"}
{"text": " 5. 合并肝、肾、造血系统等严重原发性疾病；", "label": 4, "label_text": "Disease", "id": "s3722"}
{"text": " 3．滥用非甾体类抗炎药物或其他COX-2抑制剂，研究者认为会干扰研究结果的解释；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3723"}
{"text": " 3.受试者同意参与本项目并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3724"}
{"text": " 3. 患者术前双眼合并规则角膜散光，经测量散光度 ≧ 0.75 D且 ≦2.5 D；", "label": 5, "label_text": "Multiple", "id": "s3725"}
{"text": " --无结核病密切接触者", "label": 4, "label_text": "Disease", "id": "s3726"}
{"text": "1.有严重的脏器功能障碍或疾病，如心脏、肝脏、肾脏和胰腺等严重疾病和功能障碍者；", "label": 5, "label_text": "Multiple", "id": "s3727"}
{"text": " （3）凝血功能障碍者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3728"}
{"text": " ③血流动力学不稳定或需要使用血管活性药物维持组织灌注压；", "label": 5, "label_text": "Multiple", "id": "s3729"}
{"text": " （6）体检、生化、血尿便常规及心电图、胸片、超声检查异常，且有临床意义者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3730"}
{"text": " 3. 长期接受免疫抑制剂治疗的患儿；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3731"}
{"text": " 5.严重的心血管疾病", "label": 4, "label_text": "Disease", "id": "s3732"}
{"text": " d)肿瘤位于胸段或腹段食管；", "label": 24, "label_text": "Neoplasm Status", "id": "s3733"}
{"text": " 7.神经外科手术风险大的患者(脑损伤,严重脑萎缩,凝血病,无法控制的高血压)", "label": 0, "label_text": "Therapy or Surgery", "id": "s3734"}
{"text": " 2.对亚硝脲类烷化剂过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3735"}
{"text": " 11.有严重的过敏史或特异体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3736"}
{"text": " 4) 心功能4级（NYHA）;", "label": 9, "label_text": "Risk Assessment", "id": "s3737"}
{"text": " 16)有重度过敏、非过敏性药物反应或对2种及以上的药物（含造影剂）过敏史，或已知可能对与研究药物同类的药物（氯比格雷、替格瑞洛）过敏或禁忌使用阿司匹林者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3738"}
{"text": " 10.前30天内或准备在未来的90天内行股动脉、主动脉或者颈动脉手术等大手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3739"}
{"text": "（1）年龄在30周岁到70周岁之间；", "label": 3, "label_text": "Age", "id": "s3740"}
{"text": " 4. 不稳定性心脏病。", "label": 4, "label_text": "Disease", "id": "s3741"}
{"text": " （2）单眼远近矫正视力均0.8及以上；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3742"}
{"text": " 6.近一月内未服用除方案中允许使用的其他作用于中枢神经系统的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3743"}
{"text": " 5、签署进入研究知情同意书，能积极配合并完成临床观察者。", "label": 13, "label_text": "Consent", "id": "s3744"}
{"text": "（1）患者均经病理组织学确诊为胃癌；", "label": 11, "label_text": "Diagnostic", "id": "s3745"}
{"text": " 5）妊娠期、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3746"}
{"text": " ×婴儿同时参与了其他临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s3747"}
{"text": " 2）肾功能不全：肌酐值大于3.0mg/dl", "label": 5, "label_text": "Multiple", "id": "s3748"}
{"text": " （3）伴发其他恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s3749"}
{"text": " 3）无严重全身重要脏器功能损害者", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3750"}
{"text": "①中重度急性圆锥角膜患者（水肿范围大于等于3mm）", "label": 4, "label_text": "Disease", "id": "s3751"}
{"text": " （1）白细胞计数≥3.5×109/L或中性粒细胞计数≥1.5×109/L，血小板计数≥ 100×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3752"}
{"text": " ④入组前三个月甲状腺功能正常：FT3、FT4正常，TSH正常或偏低。包括正在服用抗甲亢药物或无需服用药物者；", "label": 5, "label_text": "Multiple", "id": "s3753"}
{"text": " 5.妊娠和准备妊娠的妇女，哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3754"}
{"text": " 5)实验室检查：空腹血糖、肝酶（AST、ALT）、肾功（Bun、Cr）、心电图异常；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3755"}
{"text": " 4. 初次或第二次IVF", "label": 0, "label_text": "Therapy or Surgery", "id": "s3756"}
{"text": " 2.B细胞白血病或淋巴瘤样本CD19呈阳性", "label": 4, "label_text": "Disease", "id": "s3757"}
{"text": " (6)自愿参加研究并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3758"}
{"text": "①存在困难气道可能性者", "label": 4, "label_text": "Disease", "id": "s3759"}
{"text": " （7）精神疾病患者。", "label": 4, "label_text": "Disease", "id": "s3760"}
{"text": " 2.第一次就诊于乳腺外科门诊的女性", "label": 5, "label_text": "Multiple", "id": "s3761"}
{"text": "1. 服用相关促智药、影响脑代谢等药物的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3762"}
{"text": " 4、自愿签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3763"}
{"text": " 4.自愿参加本研究，签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s3764"}
{"text": " 18.患有任何增加出血性风险的疾病，如痔疮、急性胃炎或胃及十二指肠溃疡等。", "label": 4, "label_text": "Disease", "id": "s3765"}
{"text": " 6)既往曾安置胆道支架或胆道引流；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3766"}
{"text": " 2.术前心功能Ⅱ级及以上", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3767"}
{"text": " 3.卒中发生至随机化分组时间≤24小时", "label": 4, "label_text": "Disease", "id": "s3768"}
{"text": " 3.自愿参加本试验并同意签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3769"}
{"text": " 5. ECOG评分0~2，预期生存期须≥3个月；", "label": 5, "label_text": "Multiple", "id": "s3770"}
{"text": " 14)存在任何重度和/或未能控制的疾病的患者，包括：", "label": 4, "label_text": "Disease", "id": "s3771"}
{"text": " 3)根据JNC-7诊断标准新诊断为高血压或既往有高血压病史但至少入组前2周内未服过任何降压药；", "label": 11, "label_text": "Diagnostic", "id": "s3772"}
{"text": " ④晕针患者。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s3773"}
{"text": " （8）因各种原因不能完成治疗方案，入组后三月内失随。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3774"}
{"text": " 4)骨扫描、CT和/或MRI证实为骨转移M1b期患者，骨转移灶数目小于5个；", "label": 11, "label_text": "Diagnostic", "id": "s3775"}
{"text": " （2）《汉密尔顿抑郁量表》分大于等于20分,", "label": 9, "label_text": "Risk Assessment", "id": "s3776"}
{"text": " 2.年龄&gt;18周岁", "label": 3, "label_text": "Age", "id": "s3777"}
{"text": "①年龄：18-48周岁，", "label": 3, "label_text": "Age", "id": "s3778"}
{"text": " 10、头颅核磁共振检查颅内有明显病灶；", "label": 11, "label_text": "Diagnostic", "id": "s3779"}
{"text": " 2）年龄18-75岁，ASA I-II级", "label": 5, "label_text": "Multiple", "id": "s3780"}
{"text": "1.近6个月内有心肌梗死、不稳定性心绞痛病史；存在心动过缓（心率≤50次/分）、Ⅲ度房室传导阻滞（使用起搏器患者）等严重的心律失常病史；", "label": 4, "label_text": "Disease", "id": "s3781"}
{"text": " 12) 药物滥用者或试验前3个月使用过软毒品（如：大麻）或试验前一年及试验期间服用硬毒品（如：可卡因、苯环己哌啶，等）者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3782"}
{"text": " 5.其他原因造成研究者认为不适合入组实验的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s3783"}
{"text": " 2、7%&lt;糖化血红蛋白≤8.5%;", "label": 12, "label_text": "Laboratory Examinations", "id": "s3784"}
{"text": " （4）Waldenstrom’s巨球蛋白血症/淋巴浆细胞性淋巴瘤", "label": 4, "label_text": "Disease", "id": "s3785"}
{"text": " 2. 符合机器人胰体尾癌切除术适应症；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3786"}
{"text": " 7．预期可达到R0切除；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3787"}
{"text": " （12）受试者能够接受按项目要求定期进行回访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3788"}
{"text": " ⑵有对比剂过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3789"}
{"text": " 3)根据NCCN诊断标准为局部晚期胰腺癌。", "label": 11, "label_text": "Diagnostic", "id": "s3790"}
{"text": " 2)经过血细胞计数、骨髓形态学、骨髓活检、流式检查和细胞遗传学检查，诊断为中低危的MDS患者；", "label": 11, "label_text": "Diagnostic", "id": "s3791"}
{"text": " ⑥同意参与本试验者。", "label": 13, "label_text": "Consent", "id": "s3792"}
{"text": " ④患者乳腺内存在临床可评估的原发病灶。", "label": 4, "label_text": "Disease", "id": "s3793"}
{"text": " 13）研究者认为有不适宜参加本次临床试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s3794"}
{"text": " 9. 具备足够的骨髓、肾脏及肝功能，标准如下：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3795"}
{"text": " 2.股骨近端形态分型Dorr A或B型；", "label": 4, "label_text": "Disease", "id": "s3796"}
{"text": " 2.诊断符合中国《慢性乙型肝炎防治指南》（2005年）的慢性乙型肝炎患者，且HBeAg阳性。", "label": 5, "label_text": "Multiple", "id": "s3797"}
{"text": " (2)有心、肝、肾器官严重疾患，血象、肝肾功能明显异常者；", "label": 5, "label_text": "Multiple", "id": "s3798"}
{"text": " 16、培养后CD19-CART细胞总数未达回输标准", "label": 12, "label_text": "Laboratory Examinations", "id": "s3799"}
{"text": " （2）深夜唾液＞4 nmol/L（145 ng/dL）", "label": 12, "label_text": "Laboratory Examinations", "id": "s3800"}
{"text": "① 气道压力＞30cmH2O；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3801"}
{"text": " 16.受试者的身体器官有正在感染或炎症的情况。", "label": 4, "label_text": "Disease", "id": "s3802"}
{"text": " 心肺功能储备不能耐受手术者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3803"}
{"text": "1. 其它原因导致的白细胞减少症；", "label": 4, "label_text": "Disease", "id": "s3804"}
{"text": " 4. 女性受试者子宫和双侧卵巢生理结构基本正常。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3805"}
{"text": " 6）卡氏评分≥70; ECOG≥2", "label": 9, "label_text": "Risk Assessment", "id": "s3806"}
{"text": " 3)能够正确理解研究程序和所涉及的风险，能够通过培训适当的使用 pMDI 设备；", "label": 13, "label_text": "Consent", "id": "s3807"}
{"text": " 7)合并使用影响糖代谢的药物，如糖皮质激素等；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3808"}
{"text": " （3）BMI位于19到24", "label": 9, "label_text": "Risk Assessment", "id": "s3809"}
{"text": " 4. 做过胃肠道手术（阑尾切除术除外）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3810"}
{"text": " (3)急性胰腺炎患者", "label": 4, "label_text": "Disease", "id": "s3811"}
{"text": " ⑦患者依从性好，能理解本研究的情况并签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s3812"}
{"text": " 6.无明显心肺功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3813"}
{"text": "1.怀孕期或哺乳期的女性患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3814"}
{"text": " 困难气道；", "label": 1, "label_text": "Sign", "id": "s3815"}
{"text": " 12.正接受其他临床试验的抗癌药物治疗", "label": 15, "label_text": "Enrollment in other studies", "id": "s3816"}
{"text": " 14) 对饮食有特殊要求，不能遵守统一饮食者；", "label": 18, "label_text": "Diet", "id": "s3817"}
{"text": " 8. 肝肾功能受损：AST或ALT超过正常值上限1倍或以上；血清肌酐超过正常值上限（≥132.6 μmol/L）；", "label": 5, "label_text": "Multiple", "id": "s3818"}
{"text": " 3.乙肝性肝硬化患者，因良性肝病行手术者；", "label": 5, "label_text": "Multiple", "id": "s3819"}
{"text": " 两眼之间的等效球镜度数的差值必须小于 1.50 D（基于 5 次重复的球柱镜屈光检查的平均值）。", "label": 1, "label_text": "Sign", "id": "s3820"}
{"text": " 10.外周神经病 NCT-CTCAE≥2 级患者。", "label": 4, "label_text": "Disease", "id": "s3821"}
{"text": " 7、依从性差的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3822"}
{"text": "（1）肾功能不全，男性血清肌酐&gt;2.5mg/dl（&gt;220umo/l），女性&gt;2.0mg/dl（&gt;175umo/l）；", "label": 5, "label_text": "Multiple", "id": "s3823"}
{"text": " 3.签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3824"}
{"text": " 11.患有垂体功能异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3825"}
{"text": " 3)合并心、脑血管、肝、肾和造血系统严重原发性疾病", "label": 4, "label_text": "Disease", "id": "s3826"}
{"text": " 3.月经周期基本正常(28±7)天；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3827"}
{"text": " 7 明显肾脏疾患（血肌酐&gt;1.5mg/dL或&gt;115μmol/L）；", "label": 5, "label_text": "Multiple", "id": "s3828"}
{"text": " 3） 生命体征稳定；", "label": 1, "label_text": "Sign", "id": "s3829"}
{"text": " 8  足够的肾功能：肌酐清除率≥60 mL/min；", "label": 5, "label_text": "Multiple", "id": "s3830"}
{"text": " （2）佩带心脏起搏器、体内血糖仪或人工耳蜗等植入性或外用医疗器械；", "label": 34, "label_text": "Device", "id": "s3831"}
{"text": " 3. 无感染性发热或菌血症；", "label": 4, "label_text": "Disease", "id": "s3832"}
{"text": " 3.预期寿命少于1年；", "label": 23, "label_text": "Life Expectancy", "id": "s3833"}
{"text": " （2）身体抵抗力低下者；", "label": 4, "label_text": "Disease", "id": "s3834"}
{"text": " (2)随机化时经过积极的循环复苏后，MAP≤55mmHg的急性循环衰竭者；", "label": 5, "label_text": "Multiple", "id": "s3835"}
{"text": " （9）需要定期应用（包括注射、口服及吸入）类固醇激素和/或β受体激动剂的支气管哮喘患者；", "label": 5, "label_text": "Multiple", "id": "s3836"}
{"text": " 15)SBP＞160mmHg和（或）DBP＞95mmHg者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3837"}
{"text": " 5反复发作的胆结石、肾结石病史者；", "label": 4, "label_text": "Disease", "id": "s3838"}
{"text": " 2.双侧磨牙关系中性", "label": 30, "label_text": "Oral related", "id": "s3839"}
{"text": "1、患者病例记录信息不全；", "label": 22, "label_text": "Data Accessible", "id": "s3840"}
{"text": " （3）有癌前期皮肤损害者；", "label": 4, "label_text": "Disease", "id": "s3841"}
{"text": " ⑤BMI&gt;35", "label": 9, "label_text": "Risk Assessment", "id": "s3842"}
{"text": " 8）活动性恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s3843"}
{"text": " ③患者合并有心、肝、肾和造血系统等严重疾病；", "label": 4, "label_text": "Disease", "id": "s3844"}
{"text": " ③ 耳科疾病史，职业性或创伤性噪声暴露史，每周接触娱乐性噪声&gt;20小时，有射击爱好", "label": 5, "label_text": "Multiple", "id": "s3845"}
{"text": "1.拒绝签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s3846"}
{"text": " 4）失访的患者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3847"}
{"text": " 5)有未能控制的感染：如败血症、胆系感染、肝脓肿等；", "label": 4, "label_text": "Disease", "id": "s3848"}
{"text": " ⑶年龄≥50岁，有危险因素（氡暴露/职业暴露/恶性肿瘤史/肺癌家族史/肺部疾病史（COPD、肺纤维化）/二手烟暴露）之一的个体，性别不限。", "label": 5, "label_text": "Multiple", "id": "s3849"}
{"text": " 5)心力衰竭、不稳定型心纹痛、既往12个月内有心肌梗死病史或其他严重心脏病患者；", "label": 4, "label_text": "Disease", "id": "s3850"}
{"text": " ②不能表达或者理解之情同意者", "label": 17, "label_text": "Capacity", "id": "s3851"}
{"text": " 2、不能配合增强MRI检查；", "label": 17, "label_text": "Capacity", "id": "s3852"}
{"text": " （3）患者进食未明显受疾病影响，无脂肪代谢障碍，可自主进食；", "label": 5, "label_text": "Multiple", "id": "s3853"}
{"text": " （14）试验前3个月参加过其它临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3854"}
{"text": "贫血（Hb&lt;110g/L）", "label": 5, "label_text": "Multiple", "id": "s3855"}
{"text": "1.受试者有肝功能异常或肾功能异常，被医生认为不能参加试验；", "label": 5, "label_text": "Multiple", "id": "s3856"}
{"text": " (2)存在先天性肺发育不良、先天性呼吸道畸形、先天性膈疝、气管食管瘘、脐膨出、腹裂等及其他危及生命的先天畸形；", "label": 4, "label_text": "Disease", "id": "s3857"}
{"text": " [4]以前接受过基因治疗产品治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3858"}
{"text": " 4）慢性感染；", "label": 4, "label_text": "Disease", "id": "s3859"}
{"text": " 2）经病理细胞学和/或组织学确诊为胃癌或食管胃结合部位癌行辅助化疗者", "label": 5, "label_text": "Multiple", "id": "s3860"}
{"text": "（1）患者性别不限，年龄≥18岁；", "label": 5, "label_text": "Multiple", "id": "s3861"}
{"text": " –总胆红素≤1.5倍正常值上限（ULN）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3862"}
{"text": " 4.体重50~70kg,BMI 19~24", "label": 5, "label_text": "Multiple", "id": "s3863"}
{"text": " （2）创伤性黄斑裂孔；", "label": 4, "label_text": "Disease", "id": "s3864"}
{"text": " 2、年龄18-70岁；", "label": 3, "label_text": "Age", "id": "s3865"}
{"text": "1、符合COPD诊断标准的患者；", "label": 11, "label_text": "Diagnostic", "id": "s3866"}
{"text": " 2.近6月内两次心电图记录症状性持续性房颤；", "label": 4, "label_text": "Disease", "id": "s3867"}
{"text": " 5. 酗酒（1周饮酒5次以上，平均每次2两白酒或半斤黄酒或5瓶啤酒以上）；", "label": 2, "label_text": "Addictive Behavior", "id": "s3868"}
{"text": " ④有急、慢性传染病的患者（结核除外）；", "label": 4, "label_text": "Disease", "id": "s3869"}
{"text": " （4）孕妇或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3870"}
{"text": " 6. 近1个月内参加其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s3871"}
{"text": " （6） 有出血史，或在服用华法林等抗凝药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3872"}
{"text": "1.未经病理学确诊的患者；", "label": 11, "label_text": "Diagnostic", "id": "s3873"}
{"text": " 4正在其它临床试验中；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3874"}
{"text": " ③签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3875"}
{"text": " 4.无严重感染和心肺疾患。", "label": 4, "label_text": "Disease", "id": "s3876"}
{"text": " (3)进行性吞咽困难和吞咽痛，持续性呕吐，无意识的体重下降者；", "label": 28, "label_text": "Symptom", "id": "s3877"}
{"text": " 4. 病史提示为重度迟发过敏反应患者（反应发生在给药后1小时甚至数天，临床表现为Stevens-Johnson综合症、毒性上皮坏死溶解、剥脱性皮炎、DRESS综合症）；", "label": 5, "label_text": "Multiple", "id": "s3878"}
{"text": " 5.凝血功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3879"}
{"text": " ③术前行动障碍或身体残疾不能完成机体功能测试的患者；", "label": 5, "label_text": "Multiple", "id": "s3880"}
{"text": "① 特殊部位（眼部、外阴）有皮损者；", "label": 4, "label_text": "Disease", "id": "s3881"}
{"text": " 8）患有精神疾病；", "label": 4, "label_text": "Disease", "id": "s3882"}
{"text": " - 监护人或受试者本人知情同意，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s3883"}
{"text": " g)伴有严重感染的患者。", "label": 4, "label_text": "Disease", "id": "s3884"}
{"text": " 3.自愿退出治疗的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s3885"}
{"text": " 3. 术后在晚8点前进入ICU。", "label": 26, "label_text": "Encounter", "id": "s3886"}
{"text": " 7.1个月内用过且需要继续长期使用有肝毒性药物（包括但不限于氨苯砜，红霉素，氟康唑，酮康唑，利福平，其他抗结核制剂）或肾毒性药物（包括但不限于非甾体抗炎药，氨基糖甙类，两性霉素 B， 膦甲酸）者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3887"}
{"text": "① 胃癌根治术切口长度≥10cm", "label": 0, "label_text": "Therapy or Surgery", "id": "s3888"}
{"text": " 5、同时参与其他医学研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3889"}
{"text": " 4.有明显皮肤破损或感染者。", "label": 4, "label_text": "Disease", "id": "s3890"}
{"text": " 4.哺乳期、妊娠或计划半年内怀孕者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3891"}
{"text": " （3）有腋神经功能障碍；", "label": 4, "label_text": "Disease", "id": "s3892"}
{"text": " 8、严重肝肾疾病(严重肝脏疾病是指肝硬化、门脉高压和静脉曲张的出血，严重肾脏疾病包括透析、肾移植)；", "label": 4, "label_text": "Disease", "id": "s3893"}
{"text": " 4. 患有不易控制的精神病、传染病；", "label": 4, "label_text": "Disease", "id": "s3894"}
{"text": "   b)受试者任一只眼睛眼压（IOP）≥22mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3895"}
{"text": " 5. 除了脱发外，未恢复至CTCAE分级I级以下毒性，包括手足综合征、严重神经毒性；", "label": 5, "label_text": "Multiple", "id": "s3896"}
{"text": " c.血清肌酐（Cr）≤1.5×ULN或肌酐清除率（CCr）≥60ml/min；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3897"}
{"text": " 2)活动性乙肝（包括大三阳或小三阳）或血清学指标（HBsAg或/和HBeAg或/和HBcAb）阳性者，丙肝、肺结核、巨细胞病毒、严重真菌感染或HIV感染；", "label": 5, "label_text": "Multiple", "id": "s3898"}
{"text": " 2）患者及家属不能配合治疗；", "label": 17, "label_text": "Capacity", "id": "s3899"}
{"text": " 4.既往无结核病治疗史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3900"}
{"text": " 4.DXA测定的T值＜-2.5或者发生脆性骨折；", "label": 5, "label_text": "Multiple", "id": "s3901"}
{"text": " (4)年龄18～70岁，身体状况评分ECOG 0～2分，预计生存期≥3个月；", "label": 5, "label_text": "Multiple", "id": "s3902"}
{"text": " (2)年龄18～45周岁（含）；", "label": 3, "label_text": "Age", "id": "s3903"}
{"text": " ●脑梗死急性发病≤72小时；", "label": 4, "label_text": "Disease", "id": "s3904"}
{"text": " 5.过去一年正从癌症中康复的，或重要器官患有严重疾病的患者；", "label": 4, "label_text": "Disease", "id": "s3905"}
{"text": " 2)血常规检查异常（白细胞＜3×109/L，血红蛋白＜90g/L，中性粒细胞＜1.5×109/L，血小板＜75×109/L）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3906"}
{"text": " 6.近5 年内患有第2原发恶性肿瘤，但经过充分治疗的皮肤基底细胞癌或子宫颈原位癌除外。", "label": 4, "label_text": "Disease", "id": "s3907"}
{"text": " ⑥ 已知对任一治疗环节有过敏反应；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3908"}
{"text": " 2、发病12-24小时仍有进行性缺血性胸痛和至少2个胸前导联或肢体导联ST段抬高&gt;0.1mV,或血流动力学不稳定的患者，无直接PCI条件。", "label": 1, "label_text": "Sign", "id": "s3909"}
{"text": " （6）因风湿性心脏病、冠心病及其他心脏病合并房颤引起脑栓塞者；", "label": 4, "label_text": "Disease", "id": "s3910"}
{"text": " (3) 肺功能：室内氧饱和度≥95%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3911"}
{"text": "1）符合睡眠障碍国际分类(ICSD-3)中失眠的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3912"}
{"text": " 2. 年龄18-85岁；", "label": 3, "label_text": "Age", "id": "s3913"}
{"text": "1.年龄18~70周岁；", "label": 3, "label_text": "Age", "id": "s3914"}
{"text": " 2.创面有瘘管、窦道、感染；", "label": 4, "label_text": "Disease", "id": "s3915"}
{"text": " ② 伴有慢性重型肝炎、肝硬化、原发性肝癌、AFP 异常者;", "label": 4, "label_text": "Disease", "id": "s3916"}
{"text": " （2）青光眼患者；伴有严重或不稳定的心、肝、肾、内分泌、血液等内科疾病者；伴有其他导致急性或慢性炎性细胞因子水平异常的疾病（如系统性红斑狼疮、溃疡性结肠炎等）；", "label": 4, "label_text": "Disease", "id": "s3917"}
{"text": " 8、入组前14天内使用过处方或非处方药物者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3918"}
{"text": "①颅脑术后转入瑞金医院北院ICU；", "label": 5, "label_text": "Multiple", "id": "s3919"}
{"text": "1. 年龄≥18周岁的ICU患者", "label": 5, "label_text": "Multiple", "id": "s3920"}
{"text": " 9)缺血性心脏疾病；", "label": 4, "label_text": "Disease", "id": "s3921"}
{"text": " 21)药物滥用检查阳性者；", "label": 2, "label_text": "Addictive Behavior", "id": "s3922"}
{"text": "（1）合并其他严重疾病，严重肝肾功能异常不宜手术者；", "label": 5, "label_text": "Multiple", "id": "s3923"}
{"text": " 3)术前无明显畸形且拟行单侧TKA；", "label": 4, "label_text": "Disease", "id": "s3924"}
{"text": " 4.血、尿、便常规；血生化检查；电解质检查；凝血四项以及 X 线胸片、腹部 B 超、超声心动图、心电图检查结果未发现具有临床意义的异常。注：影像学检查（X 线胸片、腹部 B超、超声心动图）可接受 1 个月内可被研究中心认可的检查报告。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3925"}
{"text": " 12、患有严重血液系统疾病或严重凝血功能异常者；", "label": 5, "label_text": "Multiple", "id": "s3926"}
{"text": " 2)符合《中国高血压防治指南》定义的高血压诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s3927"}
{"text": " （8）凝血障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3928"}
{"text": "1.年龄≥65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s3929"}
{"text": " 2.确诊或怀疑肾脏、输尿管、膀胱、前列腺、尿道或盆腔肿瘤；", "label": 4, "label_text": "Disease", "id": "s3930"}
{"text": " （6）无麻醉药及全身麻醉禁忌证无手术禁忌证。", "label": 5, "label_text": "Multiple", "id": "s3931"}
{"text": " 5） 冠脉搭桥围手术期；", "label": 0, "label_text": "Therapy or Surgery", "id": "s3932"}
{"text": " （6）中风或脊髓损伤患者", "label": 4, "label_text": "Disease", "id": "s3933"}
{"text": " 5.肝肾功能基本正常，心电图正常。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3934"}
{"text": " （5）患有不易控制的精神病史和癫痫病史者；", "label": 4, "label_text": "Disease", "id": "s3935"}
{"text": " 3. 过去3个月内因下列疾病接受药物治疗的：胆囊炎、胆结石、消化道溃疡、尿路感染、急性肾盂肾炎、膀胱炎；", "label": 5, "label_text": "Multiple", "id": "s3936"}
{"text": " (3) 入组前基线评分，OCD患者Y-BOCS≥16分；GAD患者HAMA≥14分。", "label": 9, "label_text": "Risk Assessment", "id": "s3937"}
{"text": " 4)在3个月中曾服用过任何甾体类激素药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3938"}
{"text": " （3）患者不愿签订知情同意书。", "label": 13, "label_text": "Consent", "id": "s3939"}
{"text": " 2. 住院时间不少于72小时。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3940"}
{"text": " 12）研究者认为不适合参加本临床研究的其他疾病或情况。", "label": 21, "label_text": "Researcher Decision", "id": "s3941"}
{"text": " （4）患者同意加入本项研究", "label": 13, "label_text": "Consent", "id": "s3942"}
{"text": " ⑤患者及家属知情同意并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s3943"}
{"text": " （3）任何可能影响干预和后续行动的严重精神或身体疾病", "label": 4, "label_text": "Disease", "id": "s3944"}
{"text": " 2）吸烟史：大于20包年；", "label": 36, "label_text": "Smoking Status", "id": "s3945"}
{"text": " 5.合并严重营养不良、佝偻病，以及心、脑、肝、肾及造血等系统严重原发性疾病者；", "label": 4, "label_text": "Disease", "id": "s3946"}
{"text": " 9.年龄大于65岁。", "label": 3, "label_text": "Age", "id": "s3947"}
{"text": " d） 有不稳定心绞痛", "label": 4, "label_text": "Disease", "id": "s3948"}
{"text": " 2.乙肝两对半、肝炎系列、梅毒、或HIV等病原学检查阳性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s3949"}
{"text": " 4)有未控制的癫痫、中枢神经系统疾病或精神障碍史者。", "label": 4, "label_text": "Disease", "id": "s3950"}
{"text": "1.符合急性心肌梗死诊断28天后，至2年内的患者；", "label": 4, "label_text": "Disease", "id": "s3951"}
{"text": " 能够熟练阅读，使用中文。", "label": 25, "label_text": "Literacy", "id": "s3952"}
{"text": " 6) 孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3953"}
{"text": "1. 健康志愿者入选标准：无严重胃肠疾病史，近期无服药史。常规体检、实验室检查和影像学检查排除肝脏、胆道、胰腺以及其他系统功能障碍等可以影响胃肠动力的疾病。无胆道胰腺和胃肠手术史，胆囊B超无异常发现。", "label": 5, "label_text": "Multiple", "id": "s3954"}
{"text": " 2.妊娠或哺乳，或在试验期间计划怀孕，或在rTV疫苗接种后1个月内的密切接触者中有妊娠及哺乳者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3955"}
{"text": " 8）凝血功能障碍，免疫缺陷；用抗凝药患者，口服抗凝药不能再电极植入期间停止10天；", "label": 5, "label_text": "Multiple", "id": "s3956"}
{"text": " （3）复发或残留鼻咽癌患者；", "label": 4, "label_text": "Disease", "id": "s3957"}
{"text": "包含年龄在6到59个月之间的儿童；", "label": 3, "label_text": "Age", "id": "s3958"}
{"text": " （2）确诊为CD19+的难治复发性B细胞恶性血液病，如复发难治性慢性粒细胞白血病急淋变，Ph+急性淋巴细胞白血病和B细胞淋巴瘤；", "label": 11, "label_text": "Diagnostic", "id": "s3959"}
{"text": " 11.居住地区不在试验医院所在地区", "label": 40, "label_text": "Address", "id": "s3960"}
{"text": " 2.年龄≥18周岁", "label": 3, "label_text": "Age", "id": "s3961"}
{"text": " 12、中医认为具备热证：口舌糜烂、手脚心热、五心烦热、唇红如妆、舌红苔黄或无苔。", "label": 11, "label_text": "Diagnostic", "id": "s3962"}
{"text": "1. 患者或其法定监护人签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3963"}
{"text": " （7）过敏体质者，已知或怀疑对本试验药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3964"}
{"text": " 9.入组前1周内做过血置换的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s3965"}
{"text": " 5.糖尿病足Wagner分级0级、3级及以上；", "label": 9, "label_text": "Risk Assessment", "id": "s3966"}
{"text": " 12. 具有精神类药物滥用史且无法戒除者或有精神障碍的；", "label": 2, "label_text": "Addictive Behavior", "id": "s3967"}
{"text": "1、VVC治愈的患者", "label": 4, "label_text": "Disease", "id": "s3968"}
{"text": " 2、年龄：45岁以上。男女不限", "label": 5, "label_text": "Multiple", "id": "s3969"}
{"text": " 3.SPEED评分大于等于6分", "label": 9, "label_text": "Risk Assessment", "id": "s3970"}
{"text": " （4）精神病患者，易合并感染及出血者，过敏体质者；", "label": 5, "label_text": "Multiple", "id": "s3971"}
{"text": " 4. eGFR≥30ml/min，Scr&lt;500umol/l;", "label": 12, "label_text": "Laboratory Examinations", "id": "s3972"}
{"text": "①TIA患者或症状轻微或症状迅速改善，进展性卒中。", "label": 4, "label_text": "Disease", "id": "s3973"}
{"text": "1.B超诊断“脂肪肝”；", "label": 11, "label_text": "Diagnostic", "id": "s3974"}
{"text": " ⑥参加本项目前3个月内参加过其他药物临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s3975"}
{"text": " 8.能够遵守方案规定的研究程序和访视计划。", "label": 8, "label_text": "Compliance with Protocol", "id": "s3976"}
{"text": "1)关节活动范围受限因其他原因造成，如关节畸形或肌腱粘连等。", "label": 4, "label_text": "Disease", "id": "s3977"}
{"text": " ④　愿意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s3978"}
{"text": " 3）长期服用西药效果不佳的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3979"}
{"text": " 5）妊娠状态", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s3980"}
{"text": "       ① 频繁抽搐、昏迷、脑疝；", "label": 5, "label_text": "Multiple", "id": "s3981"}
{"text": " ⑤ GFR：60-130ml/min；24小时尿蛋白定量&lt;2.0g；", "label": 12, "label_text": "Laboratory Examinations", "id": "s3982"}
{"text": " 7. 术前有凝血功能障碍的患者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s3983"}
{"text": " 3、目前已入组或将入组其它试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s3984"}
{"text": " 8.步行、爬楼、跑步等动作受限；", "label": 27, "label_text": "Exercise", "id": "s3985"}
{"text": " （7）带状疱疹皮损发生在72小时内患者；", "label": 4, "label_text": "Disease", "id": "s3986"}
{"text": " (7) 怀疑或确有酒精、药物滥用病史，或者根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，如工作环境经常变动等易造成失访的情况。", "label": 5, "label_text": "Multiple", "id": "s3987"}
{"text": " （3）存在挛缩或骨关节畸形；", "label": 4, "label_text": "Disease", "id": "s3988"}
{"text": " (13)研究者认为其有任何原因可能不会完成本研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s3989"}
{"text": "1）患有CD19表达阳性的异基因造血干细胞移植后的急性淋巴细胞白血病患者", "label": 5, "label_text": "Multiple", "id": "s3990"}
{"text": " ②合并严重基础病者,如有糖尿病、心脑血管、肝、肾和造血系统疾病等；", "label": 4, "label_text": "Disease", "id": "s3991"}
{"text": " 3、研究者认为不适合入组的其他情况", "label": 21, "label_text": "Researcher Decision", "id": "s3992"}
{"text": "1）治疗前需要预防性使用抗生素者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3993"}
{"text": " 6.过敏性体质（对两类以上物质过敏）或对已知本制剂组成成分过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s3994"}
{"text": " （5） 已知或怀疑对地西他滨和丙戊酸过敏的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s3995"}
{"text": " 6.首次服药前3个月内，曾使用过激素替代疗法（除激素类避孕药）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s3996"}
{"text": " ③ 因严重痴呆、语言障碍、听力障碍、昏迷、终末期疾病等情况无法完成术前评估；", "label": 5, "label_text": "Multiple", "id": "s3997"}
{"text": " 5. MMSE评分小于24分。", "label": 9, "label_text": "Risk Assessment", "id": "s3998"}
{"text": " 9、疑诊或确诊1型糖尿病的患者；", "label": 11, "label_text": "Diagnostic", "id": "s3999"}
{"text": " 7) 随访时间少于2次或者未按照规定随访", "label": 8, "label_text": "Compliance with Protocol", "id": "s4000"}
{"text": " 5、无活动性传染性疾病；", "label": 4, "label_text": "Disease", "id": "s4001"}
{"text": " （2）稀发排卵诊断依据", "label": 11, "label_text": "Diagnostic", "id": "s4002"}
{"text": " 17. 已知或怀疑对研究药物的活性或非活性成分过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4003"}
{"text": "（1）急诊病人；", "label": 26, "label_text": "Encounter", "id": "s4004"}
{"text": " 2. 持续或反复发作的食欲减退、早饱或餐后饱胀等腹部不适，或上腹部（脐上）疼痛；", "label": 28, "label_text": "Symptom", "id": "s4005"}
{"text": "(1)化学烧伤、电烧伤、糖尿病等并发慢性创面者；", "label": 4, "label_text": "Disease", "id": "s4006"}
{"text": "1）门诊患者，年龄18岁～65岁（包括18岁和65岁），性别不限；", "label": 5, "label_text": "Multiple", "id": "s4007"}
{"text": " （9）血流动力学不稳定，需要大量心肌收缩力药物支持或机械性心脏辅助；", "label": 5, "label_text": "Multiple", "id": "s4008"}
{"text": " 2、ASA分级Ⅰ-Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s4009"}
{"text": " 3.年龄≥1岁，且＜70岁", "label": 3, "label_text": "Age", "id": "s4010"}
{"text": "1.任何非原发性骨质疏松症的骨病及其它代谢性骨病。", "label": 4, "label_text": "Disease", "id": "s4011"}
{"text": " 6）孕妇或哺乳期者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4012"}
{"text": " 2. 年龄18-75岁之间，性别不限；", "label": 5, "label_text": "Multiple", "id": "s4013"}
{"text": " 9、影像学检查前6小时之内使用过药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4014"}
{"text": " 5. 同意参加本研究并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s4015"}
{"text": " （6）输血传播相关疾病检查其中一项呈阳性（艾滋、丙肝、乙肝、梅毒）；", "label": 4, "label_text": "Disease", "id": "s4016"}
{"text": " (3) 肿瘤病灶可测量（妇科检查、CT/MRI测量)；", "label": 34, "label_text": "Device", "id": "s4017"}
{"text": " 4. HIV，HBV，HCV检测阳性的患者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s4018"}
{"text": " 3. 1级高血压患者（基线诊室血压，SBP 140-159mmHg和/或DBP 90-99mmHg），包括新诊断的高血压患者以及既往服用降压药物，经过4周清洗期的高血压患者；", "label": 5, "label_text": "Multiple", "id": "s4019"}
{"text": " 5.术后切口感染者", "label": 4, "label_text": "Disease", "id": "s4020"}
{"text": " 3.溶栓后出血。", "label": 1, "label_text": "Sign", "id": "s4021"}
{"text": " 3.过敏体质者，或已知对本药及成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4022"}
{"text": " （12）疑似结核或有结核病史者", "label": 4, "label_text": "Disease", "id": "s4023"}
{"text": " (2)Cobb角为10°-20°；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4024"}
{"text": " ③ 骨髓检查巨核细胞数增多或正常，有成熟障碍；", "label": 5, "label_text": "Multiple", "id": "s4025"}
{"text": " 12.精神障碍者或依从性差者；", "label": 5, "label_text": "Multiple", "id": "s4026"}
{"text": " 4. 吸烟（&gt;10支/天）；", "label": 36, "label_text": "Smoking Status", "id": "s4027"}
{"text": " 3.根据世界卫生组织（WHO）专家委员会 1999 年修订的国际诊断标准和分型，受试者为临床诊断为糖尿病患者或糖调节受损（空腹血糖受损和糖耐量下降）者；", "label": 11, "label_text": "Diagnostic", "id": "s4028"}
{"text": " 7. 已知异体器官移植（角膜移植除外）或异体造血干细胞移植；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4029"}
{"text": " （2）筛选前6个月内有酗酒（1次饮酒3升及以上）或滥用药物者；", "label": 2, "label_text": "Addictive Behavior", "id": "s4030"}
{"text": " (5)因风湿性心脏病、冠心病及其他心脏病合并房颤，引起脑栓塞者；", "label": 4, "label_text": "Disease", "id": "s4031"}
{"text": " 3.大的骨软骨骨折（直径&gt;15mm）需要手术固定", "label": 5, "label_text": "Multiple", "id": "s4032"}
{"text": " 2）精神疾病相关的失眠患者", "label": 4, "label_text": "Disease", "id": "s4033"}
{"text": " –淋巴结转移范围超出手术所能切除范围视作不可切除", "label": 0, "label_text": "Therapy or Surgery", "id": "s4034"}
{"text": "1、显微镜镜检定为单一恶性疟原虫感染者；", "label": 11, "label_text": "Diagnostic", "id": "s4035"}
{"text": " b.合并糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s4036"}
{"text": " 4）凝血功能异常（INR&gt;1.5、APTT&gt;1.5 ULN），具有出血倾向者；", "label": 5, "label_text": "Multiple", "id": "s4037"}
{"text": " 4）本人或者是其照顾者必须有能力完成流涎评分的记录", "label": 17, "label_text": "Capacity", "id": "s4038"}
{"text": " 8.自愿参加并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4039"}
{"text": "1.明确的病理诊断:周围型非小细胞型肺癌，且临床分期为Ⅲb期。", "label": 5, "label_text": "Multiple", "id": "s4040"}
{"text": " 4.患者处于严重的焦虑、兴奋或抑郁状态", "label": 28, "label_text": "Symptom", "id": "s4041"}
{"text": " 2）伴有需要全身使用免疫抑制药物或激素治疗的其他疾病；", "label": 5, "label_text": "Multiple", "id": "s4042"}
{"text": " (3)术后3月以后出现颈椎轴性症状并发症患者；", "label": 4, "label_text": "Disease", "id": "s4043"}
{"text": "（1）左主干病变介入治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4044"}
{"text": " -血清总胆红素≤1.5倍正常上限值，", "label": 12, "label_text": "Laboratory Examinations", "id": "s4045"}
{"text": " 4.既往有听力或视力障碍患者", "label": 4, "label_text": "Disease", "id": "s4046"}
{"text": " (3) 年龄≧18 周岁；", "label": 3, "label_text": "Age", "id": "s4047"}
{"text": " 17.严重疾病史或由其他证据表明为严重疾病或患有任何其他的疾病使得研究者认为患者不适合参加试验。", "label": 21, "label_text": "Researcher Decision", "id": "s4048"}
{"text": " （7）门静脉主干完全栓塞；", "label": 1, "label_text": "Sign", "id": "s4049"}
{"text": " （2）具备IVF或卵胞浆内单精子注射（Intracytoplasmic sperm injection, ICSI）助孕指征。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4050"}
{"text": "1.治疗前确诊为毛细血管瘤；", "label": 4, "label_text": "Disease", "id": "s4051"}
{"text": " 9)3个月内参与过临床试验或正在进行临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s4052"}
{"text": " 3，屈光测量参数在试验仪器测量范围内", "label": 12, "label_text": "Laboratory Examinations", "id": "s4053"}
{"text": " 5.合并严重肝肾、心肺等系统性疾病患者", "label": 4, "label_text": "Disease", "id": "s4054"}
{"text": " 10)肠内营养时发生串组（深度水解蛋白配方奶转为早产儿配方奶或由早产儿配方奶转为深度水解蛋白配方奶）", "label": 5, "label_text": "Multiple", "id": "s4055"}
{"text": " 10. 患者（包括男性患者配偶）在试验期间及末次用药后6个月内有妊娠计划、妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4056"}
{"text": " 5、既往有恶性高热家族史或者丙泊酚输注综合征；", "label": 4, "label_text": "Disease", "id": "s4057"}
{"text": " 7) 有理解力障碍而不能配合随访者", "label": 8, "label_text": "Compliance with Protocol", "id": "s4058"}
{"text": "（1）静息心电图任一导联ST段下降＞1mm；冠心病急性心肌梗死；重度或心绞痛Ⅳ级患者；肺栓塞；主动脉夹层；肥厚性心肌病及其他类型心肌病；主动脉瓣狭窄以及其他心脏瓣膜病；先天性心脏病；左束支传导阻滞、洋地黄药物影响、电解质紊乱等；", "label": 5, "label_text": "Multiple", "id": "s4059"}
{"text": " C．签署研究知情同意书；", "label": 13, "label_text": "Consent", "id": "s4060"}
{"text": " ③自愿加入本研究项目。", "label": 13, "label_text": "Consent", "id": "s4061"}
{"text": " （3）最近半年月经周期规律（25-35天）。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4062"}
{"text": " 13、自愿参加并书面签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4063"}
{"text": " 16、体循环血压较低的患者(血压&lt;90／50mmHg)或未控制的高血压患者(血压&gt;170／110mmHg)；", "label": 5, "label_text": "Multiple", "id": "s4064"}
{"text": " 6.拒绝采取适当避孕措施的育龄患者（包括男性患者）。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4065"}
{"text": " 3.本次治疗不单行LC术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4066"}
{"text": " 2.ECOG 评分0～1级；", "label": 9, "label_text": "Risk Assessment", "id": "s4067"}
{"text": " 2、服用HARRT药物3个月内出现的药疹（包括1、2、3级）；", "label": 5, "label_text": "Multiple", "id": "s4068"}
{"text": " （2）年龄18～65岁；", "label": 3, "label_text": "Age", "id": "s4069"}
{"text": "（1） 筛选期具有疟疾典型症状且血涂片疟原虫阳性者；", "label": 4, "label_text": "Disease", "id": "s4070"}
{"text": " 4.预期寿命＞3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s4071"}
{"text": " 2. 门诊病人，有记载的哮喘临床病史；", "label": 4, "label_text": "Disease", "id": "s4072"}
{"text": " 有乙型肝炎以外的其他肝病史（如脂肪肝、自身免疫性肝病、代谢性肝病等）；", "label": 4, "label_text": "Disease", "id": "s4073"}
{"text": " (4) 椎间盘突出未引起坐骨神经受累的症状和体征，或仅有腰部疼痛者。", "label": 5, "label_text": "Multiple", "id": "s4074"}
{"text": " 8.合并其它严重的器质性疾病及精神疾患；", "label": 4, "label_text": "Disease", "id": "s4075"}
{"text": " 4.平和体质人群：18.5≤体重指数（BMI）＜24；痰湿体质人群：体重指数（BMI）≥24；", "label": 9, "label_text": "Risk Assessment", "id": "s4076"}
{"text": " *有出血风险患者，活动性溃疡或消化道出血病史者；", "label": 4, "label_text": "Disease", "id": "s4077"}
{"text": " 8.已知患者对PTS或相关的化合物过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s4078"}
{"text": " （3）合并严重心脏、肺、肝脏（如转氨酶高于正常值上限1.5倍以上）、肾脏等重要疾患影响试验用药或临床评估者；", "label": 5, "label_text": "Multiple", "id": "s4079"}
{"text": " 3）   已知腔静脉异常患者，如肝脏手术术后，腔静脉狭窄或布-加综合征；", "label": 5, "label_text": "Multiple", "id": "s4080"}
{"text": " 2.根据静脉疾病临床严重评分≥9分者", "label": 9, "label_text": "Risk Assessment", "id": "s4081"}
{"text": " 3)孕妇或哺乳期病人；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4082"}
{"text": " 6. 肿瘤类别为如下18种肿瘤中的一种：肺癌，胃癌，肝癌，结直肠癌，乳腺癌，食管癌，宫颈癌，子宫内膜癌，鼻咽癌，白血病，恶性淋巴瘤，胰腺癌，卵巢癌，前列腺癌，膀胱癌，脑恶性肿瘤，胆道恶性肿瘤，胃间质瘤", "label": 4, "label_text": "Disease", "id": "s4083"}
{"text": "1、合并其他恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s4084"}
{"text": " 7.患者手术前或手术后未接受过放疗及全身化疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4085"}
{"text": " 3.根据FIGO分期为IVB期、复发性或持续性的宫颈癌患者，无法通过手术和/或放疗治愈；", "label": 5, "label_text": "Multiple", "id": "s4086"}
{"text": "1）已知对研究药物（包括本研究药物辅料）或其类似物过敏者，或过敏体质（如对两种或两种以上药物、食物和花粉过敏者）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4087"}
{"text": " 3.已知对本方案中药物成分过敏及过敏体质者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4088"}
{"text": " 3.阴道狭窄或阴道损伤", "label": 4, "label_text": "Disease", "id": "s4089"}
{"text": " 4.拟择期在腹腔镜下行妇科手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s4090"}
{"text": " 3.年龄&gt;16岁且&lt;65岁；", "label": 3, "label_text": "Age", "id": "s4091"}
{"text": " 在被告知实验方案后，不愿意入组或者没有符合医学伦理委员会对本项目的决议。", "label": 5, "label_text": "Multiple", "id": "s4092"}
{"text": "1、心肌梗死发作期或发作后伴有严重心律失常或心衰患者。", "label": 4, "label_text": "Disease", "id": "s4093"}
{"text": " （3） BCLC分期为A期或B期；", "label": 24, "label_text": "Neoplasm Status", "id": "s4094"}
{"text": " ⑤患者年龄大于18岁；", "label": 3, "label_text": "Age", "id": "s4095"}
{"text": " 10.有活动性肝脏疾病，按照当地实验室的定义，在筛选时丙氨酸转氨酶（ALT）和/或天冬氨酸转氨酶（AST）高于正常参考值范围上限的两倍。", "label": 5, "label_text": "Multiple", "id": "s4096"}
{"text": " 4. 肝功能异常或肝炎等肝病未得到控制者，以及患有研究者认为可能干扰参加研究或评估的其他疾病等；", "label": 5, "label_text": "Multiple", "id": "s4097"}
{"text": " 4. 妊娠妇女/哺乳期妇女/备孕期妇女/不能有效避孕者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4098"}
{"text": " 6.产科手术患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s4099"}
{"text": " ?患者外周血免疫细胞计数接近正常或正常水平，免疫功能检测结果接近或达到正常人群水平，心肺肝肾功能基本正常（肝功能child-push 分级A或B，Cr≤1.5倍ULN）。", "label": 5, "label_text": "Multiple", "id": "s4100"}
{"text": " 4.IBM 18-28.", "label": 9, "label_text": "Risk Assessment", "id": "s4101"}
{"text": " (6)合并有严重的心肺功能衰竭或其他严重的躯体疾病；", "label": 5, "label_text": "Multiple", "id": "s4102"}
{"text": "1)符合双腔起搏器或CRTP植入适应证，", "label": 34, "label_text": "Device", "id": "s4103"}
{"text": " 3.应符合美国麻醉协会（ ASA）Ⅰ-Ⅱ级标准，有合并疾病的患者，病情应稳定在3个月以上。", "label": 11, "label_text": "Diagnostic", "id": "s4104"}
{"text": "1.确诊为化脓性扁桃体炎、支气管炎、毛细支气管炎、肺炎等疾病患者；", "label": 4, "label_text": "Disease", "id": "s4105"}
{"text": " ①符合全球哮喘防治倡议（GINA）2017版诊断标准，目前处于慢性持续期", "label": 11, "label_text": "Diagnostic", "id": "s4106"}
{"text": " （3）有创伤性心肺复苏术（创伤性CPR≥10分钟）、2周内进行过不能实施压迫的血管穿刺以及有外伤史者。", "label": 5, "label_text": "Multiple", "id": "s4107"}
{"text": " (9) 女性患者妊娠试验是阴性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4108"}
{"text": " 3.符合《原发性痛经诊疗共识指南》诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s4109"}
{"text": " (6)已知酒精和或药物滥用", "label": 2, "label_text": "Addictive Behavior", "id": "s4110"}
{"text": "①经病理确诊为结肠癌的患者；", "label": 11, "label_text": "Diagnostic", "id": "s4111"}
{"text": " 3)需要进行操作复杂的内镜诊疗技术（如胰胆管造影术、超声内镜、内镜下黏膜切除术、内镜黏膜下层剥离术、经口内镜下肌离断术等）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4112"}
{"text": " （5）过敏体质且既往有痰热清过敏史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4113"}
{"text": " 2）哺乳期、妊娠或有可能在研究期间怀孕的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4114"}
{"text": "1.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4115"}
{"text": " （16）既往有药物滥用史，药物滥用测试（吗啡、甲基安非他明、氯胺酮、二甲基双氧安非他明、四氢大麻酚酸、可卡因）检测阳性者。", "label": 2, "label_text": "Addictive Behavior", "id": "s4116"}
{"text": " 4.已签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4117"}
{"text": " 2．肩关节病理性疾病如肿瘤，骨折、脱位、肩袖损伤、肌肉软组织外伤，肩部手术史；", "label": 5, "label_text": "Multiple", "id": "s4118"}
{"text": " 15) 合并或不能排除其他视神经病变者，影响视功能评估的视网膜病变者。", "label": 5, "label_text": "Multiple", "id": "s4119"}
{"text": " （5）肝肾功能异常或肿瘤晚期患者（肝功高于上限2倍，肾功肌酐高于上限1.2倍）；", "label": 5, "label_text": "Multiple", "id": "s4120"}
{"text": " 8)能致使受试者不能遵循研究计划甚至危及患者安全的合并症或社会环境。", "label": 5, "label_text": "Multiple", "id": "s4121"}
{"text": " 4）年龄为18～65岁男性和女性受试者（包括18岁和65岁）；", "label": 5, "label_text": "Multiple", "id": "s4122"}
{"text": " 7、签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4123"}
{"text": " （9）正在参加其他临床试验的受试者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4124"}
{"text": " (3)清洗期内连续3天有2天哮喘症状评分记分在2分以上", "label": 9, "label_text": "Risk Assessment", "id": "s4125"}
{"text": " 3.合并慢支炎、肺气肿、肺炎、哮喘等呼吸道疾病患者", "label": 4, "label_text": "Disease", "id": "s4126"}
{"text": " （7）医源性因素（如盆腔手术、放化疗、子宫动脉栓塞、药物如激素、免疫抑制剂等）引起的卵巢功能减退者；", "label": 5, "label_text": "Multiple", "id": "s4127"}
{"text": "①牙齿缺失；", "label": 30, "label_text": "Oral related", "id": "s4128"}
{"text": " 13)筛选前6个月内或筛选时FibroScan评分≤17.5 kPa，或12个月内的肝组织活检证明无肝硬化；", "label": 5, "label_text": "Multiple", "id": "s4129"}
{"text": "1、任何具有临床意义的胃肠道异常，可能损害研究药物的摄入、转运或吸收；", "label": 4, "label_text": "Disease", "id": "s4130"}
{"text": " 3.未获得知情同意，拒绝参加的患者.", "label": 13, "label_text": "Consent", "id": "s4131"}
{"text": " 2.咳嗽病程＞4周，干咳或少许白粘痰，咳嗽作为临床主要症状或唯一症状，常在夜间和（或）清晨发作，运动或遇冷空气加重，无喘息及发热等感染征象或经过较长时间抗生素治疗无效。由研究者诊断为咳嗽变异性哮喘。", "label": 5, "label_text": "Multiple", "id": "s4132"}
{"text": " （7）妊娠或准备妊娠妇女，哺乳期妇女及对研究药物已知成分过敏者。", "label": 5, "label_text": "Multiple", "id": "s4133"}
{"text": " e)年龄在18至65岁间的成人；", "label": 3, "label_text": "Age", "id": "s4134"}
{"text": " 2. 明确诊断的免疫性疾病，如SLE、APS、干燥综合征、硬皮病等；", "label": 4, "label_text": "Disease", "id": "s4135"}
{"text": "1.年龄＞21岁。", "label": 3, "label_text": "Age", "id": "s4136"}
{"text": " （2）体重指数（BMI=体重/身高2）在19-25之间（包括边界值），男性体重≥50kg，女性体重≥45kg。", "label": 5, "label_text": "Multiple", "id": "s4137"}
{"text": "1.近期有出血史致贫血；", "label": 5, "label_text": "Multiple", "id": "s4138"}
{"text": "1.接受標靶輸注靜脈麻醉的病人", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4139"}
{"text": " 2.由创伤、感染、免疫或基因疾病、或其他明确原因引起的继发性膝骨关节炎；", "label": 4, "label_text": "Disease", "id": "s4140"}
{"text": " （3）年龄在18～70岁之间。性别不限，种族不限；", "label": 5, "label_text": "Multiple", "id": "s4141"}
{"text": "a)病理证实为结直肠腺癌；", "label": 11, "label_text": "Diagnostic", "id": "s4142"}
{"text": " 2） 体重≥50kg，体重指数一般在18～26范围内，包括边界值，体重指数（BMI）＝体重（kg）/身高（m）2，体表面积1.30-1.75m2。", "label": 5, "label_text": "Multiple", "id": "s4143"}
{"text": "1、患者符合2018版《非酒精性脂肪肝病诊疗指南》中非酒精性脂肪肝病诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4144"}
{"text": " （6）有严重肝肾疾病、血液系统疾病、恶性肿瘤等系统性疾患；", "label": 4, "label_text": "Disease", "id": "s4145"}
{"text": " 4. 受试者自愿加入本研究，并签署知情同意书，依从性好，配合随访。", "label": 5, "label_text": "Multiple", "id": "s4146"}
{"text": " ⑤严重的心律失常、严重心力衰竭，NYHA分级Ⅲ级及以上者（纽约心脏协会分级Ⅲ、Ⅳ级的证据），或入选前3月内有心肌梗死或脑血管事件；", "label": 5, "label_text": "Multiple", "id": "s4147"}
{"text": " 3 意识清楚，能配合摆位及治疗；", "label": 28, "label_text": "Symptom", "id": "s4148"}
{"text": " 3.怀疑子宫严重感染", "label": 4, "label_text": "Disease", "id": "s4149"}
{"text": " 2术前有精神分裂症、癫痫、帕金森症、重症肌无力；", "label": 4, "label_text": "Disease", "id": "s4150"}
{"text": " 5)有吞咽困难或任何影响药物吸收的胃肠道疾病史。", "label": 4, "label_text": "Disease", "id": "s4151"}
{"text": " (2)脑血管病急性期，生命体征不平稳。", "label": 5, "label_text": "Multiple", "id": "s4152"}
{"text": " 5.Centor评分（扁桃体渗出，颈前淋巴结压痛，体温＞38℃，无咳嗽）≤ 1；", "label": 9, "label_text": "Risk Assessment", "id": "s4153"}
{"text": " 6.危重病人及有其它中枢神经损伤的疾病及病史，如脑外伤、脑炎、癫痫、肿瘤、感染、严重肝肾功能障碍、血液系统疾病、精神发育迟缓、精神药物滥用、精神病、中枢神经系统脱髓鞘疾病与变性疾病等的患者。", "label": 4, "label_text": "Disease", "id": "s4154"}
{"text": " 2)对试验药品有过敏史或过敏体质（多种药物及食物过敏）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4155"}
{"text": " 6. 过敏体质及对多种药物过敏症；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4156"}
{"text": " 2.具有临床症状和心脏超负荷表现，不合并需外科手术的其他心脏畸形。", "label": 5, "label_text": "Multiple", "id": "s4157"}
{"text": " 5.7.未经控制的精神疾病患者；", "label": 4, "label_text": "Disease", "id": "s4158"}
{"text": " 3）本人或其法定代理人同意签署《知情同意书》。", "label": 13, "label_text": "Consent", "id": "s4159"}
{"text": " 2.终末期肾衰竭；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s4160"}
{"text": " 3)采用切开复位钢板内固定术治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4161"}
{"text": " 严重肝功能异常（ Child-PughC 级)；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4162"}
{"text": " （2）符合汉密尔顿抑郁评量表（HAMD17）标准，诊断为抑郁症状的患者；", "label": 11, "label_text": "Diagnostic", "id": "s4163"}
{"text": " (7)合并除乙肝外的其他肝病患者，包括慢性酒精性肝炎、药物性肝损伤、自身免疫性肝病；", "label": 4, "label_text": "Disease", "id": "s4164"}
{"text": " (2) 年龄小于15岁或大于50岁，ASA评级III级以上，神经功能异常者，近期服用精神类药物者", "label": 5, "label_text": "Multiple", "id": "s4165"}
{"text": " 肝功能严重障碍，属Child-Pugh C级；", "label": 5, "label_text": "Multiple", "id": "s4166"}
{"text": " ⑥西妥昔单抗使用过敏或不能耐受者", "label": 7, "label_text": "Allergy Intolerance", "id": "s4167"}
{"text": " D 有尖端扭转型室性心动过速（TdP）病史的患者；", "label": 4, "label_text": "Disease", "id": "s4168"}
{"text": " 2.合并其他恶性肿瘤需要治疗者；", "label": 4, "label_text": "Disease", "id": "s4169"}
{"text": " 4)在筛选前三个月内献血或大量失血（&gt; 450 mL）；", "label": 5, "label_text": "Multiple", "id": "s4170"}
{"text": " ⑧研究者认为不适合参加本研究的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s4171"}
{"text": " 糖尿病血糖控制不佳", "label": 4, "label_text": "Disease", "id": "s4172"}
{"text": " 2、具有COPD危险因素（吸烟10包年以上）。", "label": 36, "label_text": "Smoking Status", "id": "s4173"}
{"text": " e. 治疗前1个月内使用抗生素患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4174"}
{"text": " (3)妊娠、哺乳期妇女或未采取有效避孕措施的育龄期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4175"}
{"text": " 8）结核病患者活动期及HIV阳性患者", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s4176"}
{"text": " (3) 既往神经肌肉疾病史者；", "label": 4, "label_text": "Disease", "id": "s4177"}
{"text": " ⑥3个月内接受过其他研究用药或参与了其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4178"}
{"text": " 2. 疤痕最大径在5cm以内；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4179"}
{"text": " ③有角膜接触镜配戴史；", "label": 34, "label_text": "Device", "id": "s4180"}
{"text": " 18)妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4181"}
{"text": " 4.如果是女性或可能怀孕者，应确证没有怀孕和非哺乳期。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4182"}
{"text": " 4 患者已经怀孕或处于哺乳期", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4183"}
{"text": " （4）合并特应性皮炎等严重过敏性疾病；", "label": 4, "label_text": "Disease", "id": "s4184"}
{"text": " 6．未行针对恶性肿瘤的化疗、放疗或激素治疗，不包括接受激素治疗的前列腺癌并获得5年以上DFS的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4185"}
{"text": " 2.肥胖组排除标准，符合以下任何一项的个体：", "label": 4, "label_text": "Disease", "id": "s4186"}
{"text": " 3)肝功能健全（BUN≤1.5倍基准值，SGPT≤2倍基准值）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4187"}
{"text": "1. ICU住院时间≥24h；", "label": 26, "label_text": "Encounter", "id": "s4188"}
{"text": "1.通过流式细胞术证实患有CD123 +急性髓性白血病的男性和女性受试者;", "label": 5, "label_text": "Multiple", "id": "s4189"}
{"text": " g. 国际标准化比值（INR）≤ 1.5，凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）≤ 1.5倍ULN；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4190"}
{"text": " ⑨近1个月内参加其它临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4191"}
{"text": " (7)自愿接受该药物治疗，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4192"}
{"text": " （10）出现房室传导阻滞患者，应立即停药并退出实验；", "label": 5, "label_text": "Multiple", "id": "s4193"}
{"text": " 5.活动性胃肠道出血；", "label": 1, "label_text": "Sign", "id": "s4194"}
{"text": "1. 6个上前牙均为活髓牙;", "label": 30, "label_text": "Oral related", "id": "s4195"}
{"text": " （2）月经初潮后的女性患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4196"}
{"text": "1.有自主能力，签署知情同意书", "label": 5, "label_text": "Multiple", "id": "s4197"}
{"text": "（1）对盐酸普萘洛尔过敏的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4198"}
{"text": "（1）有严重自杀倾向者；", "label": 28, "label_text": "Symptom", "id": "s4199"}
{"text": " （6）具备基本的独立日常生活能力；", "label": 17, "label_text": "Capacity", "id": "s4200"}
{"text": " （5）本次疾病前因为各种疾病和体质虚弱造成不能独立完成日常活动等严重影响疗效评价者；", "label": 17, "label_text": "Capacity", "id": "s4201"}
{"text": " ③ 研究者认为的任何不适合研究的因素。", "label": 21, "label_text": "Researcher Decision", "id": "s4202"}
{"text": "1）年龄18-24岁，女性；", "label": 5, "label_text": "Multiple", "id": "s4203"}
{"text": "1、直肠癌患者", "label": 4, "label_text": "Disease", "id": "s4204"}
{"text": " （7）不能提供书面知情同意书，或无法遵循试验方案者；", "label": 5, "label_text": "Multiple", "id": "s4205"}
{"text": " 3、自愿参加并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4206"}
{"text": " （3）有颈部骨折或手术史，神经功能缺损，先天脊柱异常，系统性骨或关节疾病者；", "label": 5, "label_text": "Multiple", "id": "s4207"}
{"text": " 3.存在血液系统疾病；", "label": 4, "label_text": "Disease", "id": "s4208"}
{"text": " 2.肿瘤患者；", "label": 4, "label_text": "Disease", "id": "s4209"}
{"text": " Rutherford分级 2–5级", "label": 9, "label_text": "Risk Assessment", "id": "s4210"}
{"text": " ②合并存在手足部位皮肤病变者（如化疗引起的手足综合征等）；", "label": 4, "label_text": "Disease", "id": "s4211"}
{"text": " （7）有严重并发病如脑血管病、原发性肾脏疾和可引起尿蛋白阳性疾病、血液系统疾病、 糖尿病周围神经病变以外各种神经病变、各种其他内分泌代谢疾病、精神障碍患者。", "label": 4, "label_text": "Disease", "id": "s4212"}
{"text": " 2.已经接受化学治疗、放射治疗、靶向治疗或免疫治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4213"}
{"text": "①既往患有明确的神经系统疾病、精神病病史者或人格存在异常者，如阿尔兹海默症，帕金森病综合征，多发性硬化症，精神分裂症，抑郁症等；", "label": 4, "label_text": "Disease", "id": "s4214"}
{"text": " 4.没有EGFR敏感突变(19-DEL/L858R)；", "label": 4, "label_text": "Disease", "id": "s4215"}
{"text": " (7)正在参加或准备参加其它临床试验的患者", "label": 15, "label_text": "Enrollment in other studies", "id": "s4216"}
{"text": " （8）失语、感觉障碍、严重认知功能障碍( AMT≥7分)；", "label": 4, "label_text": "Disease", "id": "s4217"}
{"text": " 4.20kg/m2 ≤BMI≤35kg/m2，体重在接受筛选前3个月内稳定，变异度≤10%；", "label": 5, "label_text": "Multiple", "id": "s4218"}
{"text": " 5、既往有异常麻醉恢复史者", "label": 19, "label_text": "Special Patient Characteristic", "id": "s4219"}
{"text": " 18、严重感染尤其是肺部感染者；", "label": 4, "label_text": "Disease", "id": "s4220"}
{"text": " 5.各种染色体／基因异常疾病", "label": 4, "label_text": "Disease", "id": "s4221"}
{"text": " 7．获得知情同意。", "label": 13, "label_text": "Consent", "id": "s4222"}
{"text": "1）合并严重恶性心律失常:包括II度以上房室传导阻滞、阵发性室性心动过速、扭转型室性心动过速等；", "label": 4, "label_text": "Disease", "id": "s4223"}
{"text": " 9．已知或怀疑对研究药物或辅料过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4224"}
{"text": "1.临床诊断或经病理组织/细胞学确诊的肝细胞癌患者", "label": 11, "label_text": "Diagnostic", "id": "s4225"}
{"text": " 4)既往有骨髓移植和/或干细胞移植史者；或其他影响骨髓造血功能的血液学疾病；", "label": 5, "label_text": "Multiple", "id": "s4226"}
{"text": "(1)原发性糖尿病、慢性肾病、心脏病、宫内感染等；", "label": 4, "label_text": "Disease", "id": "s4227"}
{"text": " 2、确诊糖尿病者；", "label": 4, "label_text": "Disease", "id": "s4228"}
{"text": " 5. 受试者无血常规、肺、肝、肾功能及心脏功能基本缺陷。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4229"}
{"text": "1.病理类型为角化性鳞状细胞癌或基底样鳞状细胞癌（WHO分型）", "label": 4, "label_text": "Disease", "id": "s4230"}
{"text": " 3、合并严重肝、肾功能损害者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4231"}
{"text": " 2.月经规律者，定义为月经周期≥21天且≤35天；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4232"}
{"text": " 4、年龄在18-65岁之间；", "label": 3, "label_text": "Age", "id": "s4233"}
{"text": " 3.体重：不低于50kg，身体质量指数【BMI=体重（kg）/身高2（m2）】在19～26范围内（包括边界值）；", "label": 5, "label_text": "Multiple", "id": "s4234"}
{"text": " 在特定的拟定步骤开始之前签署带日期的知情同意书。", "label": 13, "label_text": "Consent", "id": "s4235"}
{"text": "(1) 已经确诊为痴呆；", "label": 4, "label_text": "Disease", "id": "s4236"}
{"text": " 11、近1月内参加其他临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4237"}
{"text": " 11)任何其他的由研究者判定的明显情况或合并疾病：如内分泌、心脏、神经、肿瘤、自身免疫性疾患，其他胰腺疾病，有精神疾病史，不能使用胰岛素泵的患者。", "label": 5, "label_text": "Multiple", "id": "s4238"}
{"text": "（1）白细胞上限超过11×109/L或中性粒细胞超过80%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4239"}
{"text": " （5）经甲状腺彩超或诊断性细针穿刺活检检查明确非结节性甲状腺肿的其他疾病。", "label": 11, "label_text": "Diagnostic", "id": "s4240"}
{"text": " 12.患有其他严重的急慢性的生理或者精神问题，或实验室检查异常，会增加参加研究或者使用药物有关的风险，或干扰对研究结果的判断，且经研究者判断，认为不适合参加研究。", "label": 5, "label_text": "Multiple", "id": "s4241"}
{"text": "①严重心、肝、肾功能不全（心肌缺血或心肌梗塞、心律失常及心功能不全）者（ALT、AST≥正常值上限×1.5倍；肌酐≥正常值上限；eGFR &lt; 60 ml/min/1.73 m2）；", "label": 5, "label_text": "Multiple", "id": "s4242"}
{"text": " 7.患者和/或家属愿意参加本试验，并同意签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4243"}
{"text": " （2）合并肿瘤、感染、活动性炎症、免疫系统、造血系统疾病患者；", "label": 4, "label_text": "Disease", "id": "s4244"}
{"text": "（1）单个或2-3个肿瘤直径之和≥5cm，肿瘤分期：BCLC分期为B-C期，非弥漫性肝癌；", "label": 24, "label_text": "Neoplasm Status", "id": "s4245"}
{"text": " 重度支气管肺功能发育不良（BPD）", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4246"}
{"text": " (17)肝功能失代偿的乙肝患者（Child-Pugh 评分为B 或者 C）；", "label": 5, "label_text": "Multiple", "id": "s4247"}
{"text": " 9)精神疾病患者或无自知能力者；", "label": 4, "label_text": "Disease", "id": "s4248"}
{"text": " 10)依从性差，难以完成研究的患者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4249"}
{"text": " 4.肺动脉瓣狭窄伴需外科处理的三尖瓣重度返流。", "label": 4, "label_text": "Disease", "id": "s4250"}
{"text": " 5.无主要器官的功能障碍，血常规、肾功能、心脏功能、肺功能基本正常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4251"}
{"text": " 4）合并其他自身免疫性疾病。", "label": 4, "label_text": "Disease", "id": "s4252"}
{"text": "1.符合 2017 年卫生部肝细胞癌诊断标准的肝癌患者", "label": 11, "label_text": "Diagnostic", "id": "s4253"}
{"text": " 6)倍正常值上限，ALT≤2.5倍正常值上限；肾：Cr≤1.25倍正常值上限；骨髓：WBC ≥ 3.0×109/L, Hb ≥90 g/L, PLT ≥ 80×109/L）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4254"}
{"text": " 4. 以往出现脑梗塞、脑膜炎、颅脑损伤等疾病后遗留智力障碍的患者；", "label": 4, "label_text": "Disease", "id": "s4255"}
{"text": " 2)血清肌酐&gt;176.8μmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4256"}
{"text": " (2)规律透析，3次/周，4小时/次；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4257"}
{"text": " （4）明显心肝肾等重要器官功能衰竭及精神病患者；", "label": 5, "label_text": "Multiple", "id": "s4258"}
{"text": " 7. 病人目前或最近的3年内酗酒或滥用违禁药物。", "label": 2, "label_text": "Addictive Behavior", "id": "s4259"}
{"text": " ?筛选期前6周内有心肌梗死、不稳定型心绞痛病史；", "label": 4, "label_text": "Disease", "id": "s4260"}
{"text": " ④家系成员均为中国汉族，", "label": 31, "label_text": "Ethnicity", "id": "s4261"}
{"text": " 3.不能控制的急性失代偿期心力衰竭；器质性瓣膜疾病患者如风湿性心脏病、瓣膜先天发育异常；先天性心脏病；", "label": 4, "label_text": "Disease", "id": "s4262"}
{"text": "①排除其他原因所致的晕厥， 包括体位性低血压、 主动脉瓣狭窄、 病态窦房结综合征、 高度房室传导阻滞、 室性心律失常、 肺动脉高压、 肥厚型心肌病、 短暂性脑缺血发作、 癫痫、脑梗死或脑出血后遗症、 锁骨下静脉窃血综合征及药物诱发的晕厥等；", "label": 4, "label_text": "Disease", "id": "s4263"}
{"text": " （6）患有心脑血管、肝、肾和造血系统等严重原发性疾病；", "label": 4, "label_text": "Disease", "id": "s4264"}
{"text": " 4、筛选前30天内有活动性消化道溃疡出血的受试者，或者既往曾复发溃疡出血的受试者；", "label": 4, "label_text": "Disease", "id": "s4265"}
{"text": " 3.具有阿帕替尼的禁忌症（以说明书为准）；", "label": 4, "label_text": "Disease", "id": "s4266"}
{"text": " 2）前期接受过任何其他细胞免疫治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s4267"}
{"text": " 6. 自愿参加临床试验，已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4268"}
{"text": " （1）入组前接受任何有关ICC的放化疗、手术治疗或其他抗肿瘤治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4269"}
{"text": " 5.超声内镜细针穿刺活检病理证实为胃GIST。", "label": 11, "label_text": "Diagnostic", "id": "s4270"}
{"text": " 14. 已知药物或酒精依赖；", "label": 2, "label_text": "Addictive Behavior", "id": "s4271"}
{"text": " 2.从事过专门体育训练者；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s4272"}
{"text": " 6.长期饮酒超过5年，折合乙醇男性&gt;40g/日，女性&gt;20g/日，或2周内有大量饮酒史，折合乙醇&gt;80g/日；", "label": 39, "label_text": "Alcohol Consumer", "id": "s4273"}
{"text": " 3.本人能遵守临床研究方案的要求参加访视；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4274"}
{"text": " 4）预计生存期≥3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s4275"}
{"text": " (3)年龄18～60岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s4276"}
{"text": " （4）尿素呼气试验阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4277"}
{"text": " 2）初始治疗为大剂量甲强龙或地塞米松的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4278"}
{"text": " 5、GCS≥8分", "label": 9, "label_text": "Risk Assessment", "id": "s4279"}
{"text": "1.患有严重的心肺、血液系统疾病、恶性肿瘤、免疫功能低下患者及精神病、糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s4280"}
{"text": " (4)脑梗死后伴有意识障碍或病情严重以致不能配合相关检查的患者；", "label": 5, "label_text": "Multiple", "id": "s4281"}
{"text": " 2. 组织学和细胞学确认的，常规治疗失败或无常规标准方案治疗的晚期恶性实体肿瘤患者，其中乳腺癌、肺癌、卵巢癌、胃癌患者优先；", "label": 11, "label_text": "Diagnostic", "id": "s4282"}
{"text": " (3)移植困难者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4283"}
{"text": " 4.同意参加本试验，签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4284"}
{"text": "囊性或以囊性为主的结节（&gt;80%）；", "label": 4, "label_text": "Disease", "id": "s4285"}
{"text": " 2.入组前配戴过角膜接触镜或者使用过近视治疗的其他方案(屈光手术、渐进多焦镜、角膜塑形镜等)；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4286"}
{"text": " 4）自愿参加本试验并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4287"}
{"text": "1. 凝血功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4288"}
{"text": "伴有明显的自杀、暴力倾向、物质依赖的患者；", "label": 5, "label_text": "Multiple", "id": "s4289"}
{"text": "1.梗塞后出血患者；", "label": 4, "label_text": "Disease", "id": "s4290"}
{"text": " 5)2周以内进行过紫外线B光疗（UVB）者，4周以内进行过步骨脂素紫外光疗（PUVA）", "label": 0, "label_text": "Therapy or Surgery", "id": "s4291"}
{"text": " （4）AMI 并发左室巨大室壁瘤需行外科手术者；", "label": 5, "label_text": "Multiple", "id": "s4292"}
{"text": " （1）对矿化胶原改性PMMA骨水泥活性成分或赋形剂中任何成份有过敏史的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4293"}
{"text": " （2）放化疗及明确的药物性原因所致卵巢功能不全患者；", "label": 5, "label_text": "Multiple", "id": "s4294"}
{"text": "年龄18岁以上；", "label": 3, "label_text": "Age", "id": "s4295"}
{"text": " 6)病情危重，难以对药物有效性及安全性作出确切评价者等。", "label": 5, "label_text": "Multiple", "id": "s4296"}
{"text": " 3)姑息治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4297"}
{"text": " 2、提取的DNA的OD值（OD260/OD280）未在1.6-2.0之间，经重新提取或纯化仍无法达到要求的样本应剔除。", "label": 12, "label_text": "Laboratory Examinations", "id": "s4298"}
{"text": " 7. 因SAP进行急诊大手术后的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s4299"}
{"text": " 14.根据研究者的判断，具有降低入组可能性或使入组复杂化的其他病变或情况，如工作或居住环境经常变动等易造成失访的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s4300"}
{"text": "①大于18岁；", "label": 3, "label_text": "Age", "id": "s4301"}
{"text": " 无症状性低血糖史", "label": 4, "label_text": "Disease", "id": "s4302"}
{"text": " 2. 年龄≧18且 ≦45周岁；", "label": 3, "label_text": "Age", "id": "s4303"}
{"text": " 4)7%≤HbA1c≤10.0%", "label": 12, "label_text": "Laboratory Examinations", "id": "s4304"}
{"text": "1、合并有严重心血管(如心肌梗死、心力衰竭、严重心力衰竭等)、肺部(如肺功能不全等)、肝脏、肾脏、造血系统等疾病的患者；", "label": 5, "label_text": "Multiple", "id": "s4305"}
{"text": " 6.不能依从本研究步骤者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4306"}
{"text": " 6.在本次发病后近2周内使用过与本病相关的中西医治疗药物且病情不允许或个人不愿意进入为期2周的药物洗脱期的患者。", "label": 5, "label_text": "Multiple", "id": "s4307"}
{"text": "1. 本研究组31个中心2010年8月1日以后经骨髓细胞形态学、免疫学、遗传学确诊的除急性早幼粒细胞白血病以外的初治急性髓系白血病患者。", "label": 11, "label_text": "Diagnostic", "id": "s4308"}
{"text": " 14)研究者认为有不适宜参加本次临床试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s4309"}
{"text": " 4. 过敏体质，对两种或两种以上药物或食物过敏或已知对本药物的主要成份以及辅料有过敏史者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4310"}
{"text": " 2.平时无运动锻炼习惯；", "label": 27, "label_text": "Exercise", "id": "s4311"}
{"text": " (8)不符合纳入标准、未按规定服药、无法判断疗效或资料不全等影响疗效判断者；", "label": 5, "label_text": "Multiple", "id": "s4312"}
{"text": "（1）ED病史至少六个月的男性", "label": 5, "label_text": "Multiple", "id": "s4313"}
{"text": " 3、起病12小时内行PCI治疗者", "label": 4, "label_text": "Disease", "id": "s4314"}
{"text": " （4）过敏体质，或对本药已知成分过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4315"}
{"text": " ⑦全身性疾病如疼痛、发热、咳嗽、手术等，外界环境干扰因素或颅脑外伤引起；⑧合并有心血管、肺、肝、肾和造血系统等严重原发疾病和脑器质性疾病；", "label": 5, "label_text": "Multiple", "id": "s4316"}
{"text": " 5.72小时出现多器官功能衰竭者", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4317"}
{"text": " 2、肝肾功能不全", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4318"}
{"text": " 11.试验前3个月参加过其他临床研究者，服药期间或服药停止后3个月内准备生育者；", "label": 5, "label_text": "Multiple", "id": "s4319"}
{"text": "(1)2个月内参加过其它临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4320"}
{"text": " （5）其他严重并发症或合并症，如心、肾功能衰竭", "label": 5, "label_text": "Multiple", "id": "s4321"}
{"text": "（1）呼吸状态不稳定，需大幅度调整呼吸机参数（PEEP&gt;=12cmH2O,FiO2调整幅度&gt;5%）；", "label": 5, "label_text": "Multiple", "id": "s4322"}
{"text": " （2）在ICU住院，并且接受无创通气的患者", "label": 38, "label_text": "Nursing", "id": "s4323"}
{"text": "（1）符合肩关节周围炎西医诊断标准的患者；", "label": 11, "label_text": "Diagnostic", "id": "s4324"}
{"text": " ④新辅助化疗患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4325"}
{"text": " (5)实验室检查(血尿常规、肝肾功能和心电图检查)发现血液、心、肝和肾功能不全者。", "label": 5, "label_text": "Multiple", "id": "s4326"}
{"text": " (9)有其他合并感染证据：HAV/HCV/HEV/HIV抗体阳性者；", "label": 5, "label_text": "Multiple", "id": "s4327"}
{"text": " ⑤ 近三个月内未参加其他医学临床试验研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4328"}
{"text": " 4、无神经功能障碍；", "label": 4, "label_text": "Disease", "id": "s4329"}
{"text": " ECOG&lt;=2", "label": 9, "label_text": "Risk Assessment", "id": "s4330"}
{"text": "1.其他原因导致的血小板减少症；", "label": 4, "label_text": "Disease", "id": "s4331"}
{"text": " 2 严重的肝脏、心脏或系统疾病；", "label": 4, "label_text": "Disease", "id": "s4332"}
{"text": "1. 患者或其法定监护人签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s4333"}
{"text": " C. 任何不稳定的系统系疾病（包括急性感染、重大心血管疾病 {包括过去1年内的心肌梗死} ，任何严重的肝脏、肾脏或代谢性疾病）、代谢障碍。", "label": 4, "label_text": "Disease", "id": "s4334"}
{"text": " (6)使用靶向药物治疗者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4335"}
{"text": " 7)合并有肝、肾、造血系统、内分泌系统等严重疾病者；", "label": 4, "label_text": "Disease", "id": "s4336"}
{"text": " 5)眼部感染；", "label": 4, "label_text": "Disease", "id": "s4337"}
{"text": " (3)从未接受过ARV或HIV治疗性疫苗且同意基线访视前不开始ART", "label": 5, "label_text": "Multiple", "id": "s4338"}
{"text": "（1）必须签署了知情同意；", "label": 13, "label_text": "Consent", "id": "s4339"}
{"text": " (1)确诊为神经管闭合不全；", "label": 11, "label_text": "Diagnostic", "id": "s4340"}
{"text": " 3. 受试者法定监护人签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4341"}
{"text": " 5）体重指数18≤BMI≤28；", "label": 9, "label_text": "Risk Assessment", "id": "s4342"}
{"text": "①术前3月内急性肺损伤或急性呼吸窘迫综合征病史；", "label": 4, "label_text": "Disease", "id": "s4343"}
{"text": " 2. 美国麻醉医师协会（ASA）分级Ⅰ~Ⅱ级，肛肠手术患者", "label": 5, "label_text": "Multiple", "id": "s4344"}
{"text": " 3.已有可移植优质胚胎≥2枚", "label": 29, "label_text": "Receptor Status", "id": "s4345"}
{"text": " （8）患有明显的心、肺疾病者", "label": 4, "label_text": "Disease", "id": "s4346"}
{"text": "1）符合阵发性房颤诊断标准，证属气虚血瘀、痰热内扰的患者；", "label": 11, "label_text": "Diagnostic", "id": "s4347"}
{"text": " （6）过敏体质者，已知或怀疑对本试验药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4348"}
{"text": " 7）肢体残疾行动不便者; 无固定地址易失访者；", "label": 5, "label_text": "Multiple", "id": "s4349"}
{"text": " 4.合并心肝肾等重要器官和（或）造血系统等严重原发疾病者；", "label": 4, "label_text": "Disease", "id": "s4350"}
{"text": " 2.符合乳腺增生病中医证候诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4351"}
{"text": " (7) 根据GCP规定，获取知情同意，志愿受试", "label": 13, "label_text": "Consent", "id": "s4352"}
{"text": " 12以及近一个月内经历其他手术、跌打损伤、外伤（含骨折）等的志愿者；", "label": 5, "label_text": "Multiple", "id": "s4353"}
{"text": " 3）经病理学和/或细胞学证实为宫颈癌患者， 病理类型包括鳞癌和腺癌", "label": 11, "label_text": "Diagnostic", "id": "s4354"}
{"text": " 7、有严重腹泻或者呕吐，活动性上消化道溃疡或吸收不良", "label": 5, "label_text": "Multiple", "id": "s4355"}
{"text": " 2)既往心肌梗死病史；", "label": 4, "label_text": "Disease", "id": "s4356"}
{"text": "(1)年龄为18岁≤年龄≤30岁，右利手的健康男性；", "label": 5, "label_text": "Multiple", "id": "s4357"}
{"text": " 11. 器官移植需要免疫抑制治疗者", "label": 0, "label_text": "Therapy or Surgery", "id": "s4358"}
{"text": "1）美国麻醉医师协会分级≥Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s4359"}
{"text": " 10.对试验药物过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s4360"}
{"text": " 8．预期寿命不足1年的患者（如多器官功能衰竭、恶性肿瘤）；", "label": 23, "label_text": "Life Expectancy", "id": "s4361"}
{"text": " （9）目前正在应用β受体阻滞剂治疗者，包括局部应用；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4362"}
{"text": " 诊断前列腺腺癌时存在其他恶性肿瘤或既往有其他恶性肿瘤病史者。", "label": 4, "label_text": "Disease", "id": "s4363"}
{"text": " （2）18岁≤ 年龄≤ 65岁，不考虑性别、民族。", "label": 5, "label_text": "Multiple", "id": "s4364"}
{"text": " （3）肝肾功能正常。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4365"}
{"text": "-经活检和MRI或超声内镜证实为局部晚期直肠癌（TNM分期：T3-4NxM0）；", "label": 11, "label_text": "Diagnostic", "id": "s4366"}
{"text": " 3 正在参加其他临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4367"}
{"text": " 9）有中度以上贫血的患者。", "label": 4, "label_text": "Disease", "id": "s4368"}
{"text": " 6.近6月内服用过以下药物:糖皮质激素、秋水仙碱、别嘌醇、苯溴马隆、免疫抑制剂（巯唑嘌呤、6-巯基嘌呤、环孢素、环磷酰胺）、化疗药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4369"}
{"text": " （3）经知情同意并且自愿签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s4370"}
{"text": " 7.简易认知精神功能评估量表积分为＜17分。", "label": 9, "label_text": "Risk Assessment", "id": "s4371"}
{"text": " 4、活动性感染，如：临床证实上呼吸道感染，活动性的乙型肝炎感染（HBV DNA荧光定量&gt;1.0E+6 IU/ml）；", "label": 5, "label_text": "Multiple", "id": "s4372"}
{"text": " （5）年龄在18周岁到30周岁", "label": 3, "label_text": "Age", "id": "s4373"}
{"text": " 2）合并伸肌腱损伤者；", "label": 4, "label_text": "Disease", "id": "s4374"}
{"text": " 肝脏：血清胆红素≤2倍正常值上限，转氨酶AST和ALT≤2.5倍正常值上限。", "label": 12, "label_text": "Laboratory Examinations", "id": "s4375"}
{"text": " ②年龄25～60岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s4376"}
{"text": " 7.存在末梢神经病变的患者，CTC分级≥2。", "label": 5, "label_text": "Multiple", "id": "s4377"}
{"text": " （2）年龄在18岁以下，65岁以上的患者；", "label": 3, "label_text": "Age", "id": "s4378"}
{"text": " 18) 有酗酒和滥用药物史的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s4379"}
{"text": "1.组织学确诊为宫颈鳞癌或腺癌，肿块大小≤4cm", "label": 11, "label_text": "Diagnostic", "id": "s4380"}
{"text": " 3、   健康对照组来自空军军医大学第二附属医院门诊体检中心人群，无主观不适30例；HAMD-24项总分≤8分。", "label": 5, "label_text": "Multiple", "id": "s4381"}
{"text": "1、有明显肺部感染需抗感染治疗者（就诊前4周内呼吸道感染者及全身感染者）；", "label": 5, "label_text": "Multiple", "id": "s4382"}
{"text": " ⑥不同意签署本研究的知情同意书。", "label": 13, "label_text": "Consent", "id": "s4383"}
{"text": " 29. 研究者判断其他可能影响临床研究进行及研究结果判定的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s4384"}
{"text": " 8. 预计术后需要进入ICU接受进一步治疗者；", "label": 26, "label_text": "Encounter", "id": "s4385"}
{"text": " ② 妊娠哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4386"}
{"text": " 6.近半年未参加过其他临床试验,知情并自愿接受临床研究者。", "label": 5, "label_text": "Multiple", "id": "s4387"}
{"text": " 7.当前符合任何轴I诊断者；", "label": 11, "label_text": "Diagnostic", "id": "s4388"}
{"text": " 14)（问诊）每天饮用过量茶、咖啡和/或含咖啡因的饮料（8杯以上，1杯=250 mL）者；", "label": 18, "label_text": "Diet", "id": "s4389"}
{"text": " 8．1个月内未行胸腔内注射抗肿瘤药或硬化剂", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4390"}
{"text": " 5.明显肝、肾功能异常者（ALT大于2.5倍正常高限，或eGFR&lt;45 mL/min per 1?73 m2）", "label": 5, "label_text": "Multiple", "id": "s4391"}
{"text": " ②昏迷。", "label": 28, "label_text": "Symptom", "id": "s4392"}
{"text": " 5.预计存活时间&lt;1年", "label": 23, "label_text": "Life Expectancy", "id": "s4393"}
{"text": "1.活动性出血患者。", "label": 1, "label_text": "Sign", "id": "s4394"}
{"text": " 2.月经周期规律者（25-35天）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4395"}
{"text": "（1）所有病例均符合急性胰腺炎亚特兰大分类标准修订（2012）中SAP诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4396"}
{"text": " （2） 之前有练习过太极拳；", "label": 27, "label_text": "Exercise", "id": "s4397"}
{"text": " b） 牙齿必须健全坚固，与上、下和邻牙接触关系正常。", "label": 30, "label_text": "Oral related", "id": "s4398"}
{"text": " ④临床病情稳定，血压、血糖等基础病控制良好；", "label": 1, "label_text": "Sign", "id": "s4399"}
{"text": " 6)经常或正在使用酶诱导剂或抑制剂等影响药物代谢的药物，如性激素，苯妥英，巴比妥，普里米酮，卡巴咪嗪，利福平，灰黄霉素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4400"}
{"text": "1.三年内有慢性或活动性消化道疾病如食管疾病、胃炎、胃溃疡、肠炎，活动性胃肠道出血或消化道手术者（筛查期问诊）；", "label": 5, "label_text": "Multiple", "id": "s4401"}
{"text": " (7)肾移植术后；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4402"}
{"text": " 4.正在服用激素、免疫抑制剂、抗生素者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4403"}
{"text": " （4）3个月内发生的ACS或心力衰竭或预期进行PCI或CABG术者；", "label": 5, "label_text": "Multiple", "id": "s4404"}
{"text": " 3）患者入组前 4 周内患有无法控制的感染疾病；", "label": 4, "label_text": "Disease", "id": "s4405"}
{"text": " b)首次因脑血管意外后遗留肢体偏瘫；", "label": 4, "label_text": "Disease", "id": "s4406"}
{"text": " 19)  在研究前筛选阶段或研究用药前发生急性疾病；", "label": 4, "label_text": "Disease", "id": "s4407"}
{"text": "1、在过去5年中曾有过或伴随有任何恶性肿瘤的患者除了已治疗的皮肤基底或鳞状细胞癌、子宫颈原位癌或膀胱原位癌、乳腺原位癌；", "label": 4, "label_text": "Disease", "id": "s4408"}
{"text": " 7. 患有不易控制的精神病史者；", "label": 4, "label_text": "Disease", "id": "s4409"}
{"text": "（1）吸烟者；", "label": 36, "label_text": "Smoking Status", "id": "s4410"}
{"text": " （4）年龄35-60周岁，男女不限?；", "label": 5, "label_text": "Multiple", "id": "s4411"}
{"text": " 8. 孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4412"}
{"text": " 17.严重视网膜病或临床相关的眼科疾病的病史（如由于高血压或糖尿病，CMV视网膜炎，黄斑变性）", "label": 4, "label_text": "Disease", "id": "s4413"}
{"text": " 6) 难以完成随访者，或影响顺应性的各种因素。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4414"}
{"text": " 10)试验期间或试验结束后三个月内有怀孕或者生育打算或不能保证在此期间的性生活中采用一种或一种以上避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4415"}
{"text": "（1）已知对研究药物或其成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4416"}
{"text": " （2）年龄18岁~90岁；", "label": 3, "label_text": "Age", "id": "s4417"}
{"text": " （5）自愿接受治疗且治疗期间不行放疗及其他治疗，如针灸、免疫治疗、生物治疗等。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4418"}
{"text": " 5.双胎妊娠；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4419"}
{"text": " 2.确诊甲状腺疾病或垂体疾病影响甲状腺激素水平者", "label": 4, "label_text": "Disease", "id": "s4420"}
{"text": " （6）未按规定用药，无法判断疗效或资料不全等影响疗效或安全性判断者；", "label": 22, "label_text": "Data Accessible", "id": "s4421"}
{"text": " 2)合并其他原因导致的肝脏病变如病毒性肝炎（如HBsAg或抗HCV阳性等），肝硬化，药物性肝损伤，自身免疫 性疾病，代谢性肝病等", "label": 4, "label_text": "Disease", "id": "s4422"}
{"text": " 10. 严重肝病患者或肝功能不全（ALT、AST或TBIL&gt;2倍正常参考值上限）；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4423"}
{"text": "1.依据张之南主编的《血液病诊断及疗效标准》初次确诊的多发性骨髓瘤患者，年龄≥18岁;", "label": 5, "label_text": "Multiple", "id": "s4424"}
{"text": " （7）供受体ABO血型不符合；", "label": 29, "label_text": "Receptor Status", "id": "s4425"}
{"text": " 3.患者具有典型的上腹部及背部慢性疼痛。", "label": 28, "label_text": "Symptom", "id": "s4426"}
{"text": " 2.伴有糖尿病、心脑血管、下肢动脉疾病、下肢皮肤感染性疾病的患者", "label": 4, "label_text": "Disease", "id": "s4427"}
{"text": " I)过敏性体质患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4428"}
{"text": " 6、正在参与其他干预性试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4429"}
{"text": " 4. 孕妇。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4430"}
{"text": " (9)拒绝入组和随访患者", "label": 5, "label_text": "Multiple", "id": "s4431"}
{"text": " 4、能够充分理解此研究的目的和了解可能的不良反应，自愿参加实验并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4432"}
{"text": "1.怀孕中;", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4433"}
{"text": "(1)年龄18～65岁", "label": 3, "label_text": "Age", "id": "s4434"}
{"text": " 2.一般状况好，ECOG  PS评分：0-1分；", "label": 9, "label_text": "Risk Assessment", "id": "s4435"}
{"text": " (5)虽然存在动-静脉瘘或动-门脉瘘，但可进行彻底栓堵者；", "label": 5, "label_text": "Multiple", "id": "s4436"}
{"text": "（1）急性心肌梗死；", "label": 4, "label_text": "Disease", "id": "s4437"}
{"text": " （2）并发登革休克，出现心动过速、肢端湿冷、毛细血管充盈时间延长&gt;3秒、脉搏细弱或测不到、脉压差减小或血压测不到等；", "label": 5, "label_text": "Multiple", "id": "s4438"}
{"text": " 5、未签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4439"}
{"text": " 3）按照美国国家综合癌症网络（NCCN）ALL临床实践指南（2016.v1）标准，经组织学确诊为CD19+B-ALL的患者", "label": 11, "label_text": "Diagnostic", "id": "s4440"}
{"text": "①严重心肺功能障碍", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4441"}
{"text": "1.妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4442"}
{"text": " 7.诊断IV期后既往曾给与一线治疗，既往未使用过Docetaxel；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4443"}
{"text": " （5）有明确诊断的严重精神障碍患者", "label": 4, "label_text": "Disease", "id": "s4444"}
{"text": " 5、全部采用自体腓骨长肌腱前侧半进行重建。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4445"}
{"text": " 对丁香、姜半夏及生姜任意一药过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4446"}
{"text": " 8、漂浮导管组要求“血流动力学指标肺毛细血管楔压（PCWP）≥13mmHg”", "label": 12, "label_text": "Laboratory Examinations", "id": "s4447"}
{"text": " 13)妊娠期或哺乳期的患者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4448"}
{"text": " 1)血常规检查标准需符合：ANC≥1.5×109/L，PLT≥75×109/L，Hb≥90g/L（14天内未输血及血制品，未使用G-CSF及其他造血刺激因子纠正）", "label": 5, "label_text": "Multiple", "id": "s4449"}
{"text": "1、年龄在18～65岁之间", "label": 3, "label_text": "Age", "id": "s4450"}
{"text": " (3)女性患者必须满足以下条件之一：a、绝经至少1年；b、已行绝育手术；c、具有生育能力者需同时满足下列条件：入选时尿妊娠试验阴性、在试验期间采取可靠避孕措施者、非哺乳期；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4451"}
{"text": " 4）双眼除屈光不正外无其他异常或疾病；", "label": 4, "label_text": "Disease", "id": "s4452"}
{"text": " 3.对紫杉醇注射液过敏的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4453"}
{"text": " 5.照射区皮肤有皮疹、破损、感染者。", "label": 4, "label_text": "Disease", "id": "s4454"}
{"text": "1. 常规指标异常:红蛋白&lt;10gm/dL,血小板计数&lt;100k/mm3,嗜中性粒细胞计数&lt;1000/mm3;", "label": 12, "label_text": "Laboratory Examinations", "id": "s4455"}
{"text": " g)近期(1-3个月)服用益生菌制品或长期食用酸奶、益生菌饮料；", "label": 18, "label_text": "Diet", "id": "s4456"}
{"text": " （6）已排除内分泌原因导致的月经量少；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4457"}
{"text": " 5）Child-pugh评分≥13", "label": 9, "label_text": "Risk Assessment", "id": "s4458"}
{"text": " （5）分组前4周内未使用包括PDE5-i在内的其他方式治疗ED；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4459"}
{"text": " &lt;9&gt;不遵医嘱或不能按时复诊者", "label": 8, "label_text": "Compliance with Protocol", "id": "s4460"}
{"text": "1.年龄：≥18岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s4461"}
{"text": " (3)胸部CT检查发现有空洞型阴影或多发病灶；", "label": 11, "label_text": "Diagnostic", "id": "s4462"}
{"text": " j.使用或需要任何可能改变正常眼部发现的全身用药或局部药物/已知会在入组时和/或在研究期间以不利或有益的方式影响受试者的眼部健康/生理情况；", "label": 5, "label_text": "Multiple", "id": "s4463"}
{"text": " (11)对猪的胶原蛋白过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s4464"}
{"text": " 9. 活动性溃疡", "label": 4, "label_text": "Disease", "id": "s4465"}
{"text": " c)术前患侧听力C-D级（AAO-HNS分级）", "label": 9, "label_text": "Risk Assessment", "id": "s4466"}
{"text": " 5．已知对试验药品或相关产品过敏。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4467"}
{"text": " (2)未出现表皮生长因子抑制剂（EGFRIs）治疗相关的皮肤干燥。", "label": 5, "label_text": "Multiple", "id": "s4468"}
{"text": " 凝血性障碍患者；", "label": 4, "label_text": "Disease", "id": "s4469"}
{"text": "1. 屈光介质混浊难以进行眼底图像评价者。", "label": 1, "label_text": "Sign", "id": "s4470"}
{"text": " 3 妊娠妇女及哺乳期女性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4471"}
{"text": " 3.行神经阻滞麻醉的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4472"}
{"text": " 8)AST和/或ALT＞正常上限的5倍；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4473"}
{"text": "1、年龄18-60岁;", "label": 3, "label_text": "Age", "id": "s4474"}
{"text": " 慢性溃疡为达骨骼", "label": 4, "label_text": "Disease", "id": "s4475"}
{"text": " ③ 初中以上文化水平，阅读报纸无障碍者。", "label": 5, "label_text": "Multiple", "id": "s4476"}
{"text": " 2.HAMD 量表17项得分≥17分；", "label": 9, "label_text": "Risk Assessment", "id": "s4477"}
{"text": " 6.不能理解或遵从研究方案", "label": 8, "label_text": "Compliance with Protocol", "id": "s4478"}
{"text": " (3)服用影响胃肠动力药物的患者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4479"}
{"text": " 5.预计生存期≥3月；", "label": 23, "label_text": "Life Expectancy", "id": "s4480"}
{"text": " (5) 无神经系统疾患，能够正常言语交流；", "label": 5, "label_text": "Multiple", "id": "s4481"}
{"text": "1.糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s4482"}
{"text": " （6）根据术前评估需要做全胃切除的患者）", "label": 0, "label_text": "Therapy or Surgery", "id": "s4483"}
{"text": "（1）严重的心脏、肾脏、肺部及肝脏疾病；", "label": 4, "label_text": "Disease", "id": "s4484"}
{"text": " *自愿签署知情同意书;", "label": 13, "label_text": "Consent", "id": "s4485"}
{"text": " 6、试验前1周内未使用长效β2受体激动剂、口服β2受体激动剂或吸入性抗胆碱能受体制剂。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4486"}
{"text": " 3.本次入组时正在接受其他临床中枢神经干预的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4487"}
{"text": " 5. 结核病患者；", "label": 4, "label_text": "Disease", "id": "s4488"}
{"text": " 5.凝血检查：PT：INR＜1.7；SO2 &gt;90%(室温下)；射血分数(EF) &gt;55%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4489"}
{"text": " 25. 任何显示长期使用苯二氮?类药物的迹象（如失眠，焦虑，痉挛）或筛选期尿液药物筛查呈现阳性；", "label": 5, "label_text": "Multiple", "id": "s4490"}
{"text": " 7.对试验用药过敏的患儿；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4491"}
{"text": " 10、认知功能障碍不能给予充分知情同意者；", "label": 5, "label_text": "Multiple", "id": "s4492"}
{"text": " （3）18 kg/m^2 ＜BMI ＜36 kg/m^2；", "label": 9, "label_text": "Risk Assessment", "id": "s4493"}
{"text": " 4）有精神或神经病患者；", "label": 4, "label_text": "Disease", "id": "s4494"}
{"text": "术前谵妄、精神分裂症、阿尔兹海默症、其他类型痴呆及脑卒中；", "label": 4, "label_text": "Disease", "id": "s4495"}
{"text": "1.受试者有酒精滥用史，药物滥用史和/或阿片滥用史；", "label": 2, "label_text": "Addictive Behavior", "id": "s4496"}
{"text": "1、膝关节外翻畸形伴外侧间隙狭窄、疼痛", "label": 5, "label_text": "Multiple", "id": "s4497"}
{"text": " 3）病程≥1年；", "label": 4, "label_text": "Disease", "id": "s4498"}
{"text": " 5.签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4499"}
{"text": " 依从性差；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4500"}
{"text": " - 心电图及肺功能检查未显示明显异常者；", "label": 11, "label_text": "Diagnostic", "id": "s4501"}
{"text": " 6.男女不限", "label": 35, "label_text": "Gender", "id": "s4502"}
{"text": " 5.怀孕", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4503"}
{"text": " 3）患者很大可能不会依从研究方案治疗和随访计划", "label": 8, "label_text": "Compliance with Protocol", "id": "s4504"}
{"text": " 5.治疗过程中接受含有金银花、苦参等清热解毒类的中药或中成药口服；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4505"}
{"text": " 7)严重的或未良好控制的高血压（SBP&gt;180mmHg或DBP&gt;110mmHg）；", "label": 5, "label_text": "Multiple", "id": "s4506"}
{"text": " 2）血液动力学不稳定或急性肺水肿；", "label": 4, "label_text": "Disease", "id": "s4507"}
{"text": "1. 目前有血流感染；", "label": 4, "label_text": "Disease", "id": "s4508"}
{"text": "(1) 符合美国精神障碍诊断统计手册第五版（DSM-V）的焦虑障碍的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4509"}
{"text": " 5、其他慢性肝病（如自身免疫性肝炎）病史或临床症状。", "label": 4, "label_text": "Disease", "id": "s4510"}
{"text": " 3）有活动性恶性肿瘤病史(签署知情同意书前5年以内未治疗或未复发的病人除外)；", "label": 5, "label_text": "Multiple", "id": "s4511"}
{"text": " 3. 家族性遗传疾病；", "label": 4, "label_text": "Disease", "id": "s4512"}
{"text": " 3.18≤BMI≤28kg/m2", "label": 9, "label_text": "Risk Assessment", "id": "s4513"}
{"text": " 8. 重要脏器有原发性疾病；", "label": 4, "label_text": "Disease", "id": "s4514"}
{"text": " 5) 有心、肝、肾、消化道、神经系统、精神异常及代谢异常等病史；", "label": 4, "label_text": "Disease", "id": "s4515"}
{"text": " 7.大便隐血阳性者；", "label": 4, "label_text": "Disease", "id": "s4516"}
{"text": "1) 年龄18周岁以上；", "label": 3, "label_text": "Age", "id": "s4517"}
{"text": " 4.体重在理想体重的80%～120%之间；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4518"}
{"text": " （2）确诊主动脉瓣重度狭窄（定义为主动脉瓣有效瓣口面积≤1.0cm2，或平均跨主动脉瓣压力阶差≥40mmHg，或跨瓣峰流速≥4.0m/s）且有明显的相关临床症状；如果符合上述超声心动图入组标准的患者在基线手术前接受了球囊主动脉瓣膜成形术（Balloon Aortic Valvuloplasty，BAV），而不再满足主动脉瓣有效瓣口面积、主动脉瓣平均跨瓣压差或跨瓣峰流速的入选标准，患者仍可基于BAV前的超声心动图结果入组。", "label": 5, "label_text": "Multiple", "id": "s4519"}
{"text": " 2.中等量丘脑出血患者（10-30ml);", "label": 1, "label_text": "Sign", "id": "s4520"}
{"text": " 5)妊娠或哺乳期患者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4521"}
{"text": " 3.神经系统、前庭系统等疾病；", "label": 4, "label_text": "Disease", "id": "s4522"}
{"text": " 7) HIV感染患者", "label": 4, "label_text": "Disease", "id": "s4523"}
{"text": " （4）入组前4个月曾接受患肢肉毒毒素注射治疗，入组前2周接受患肢局部神经肌肉封闭或口服解痉剂治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4524"}
{"text": " ④能够通过文字或口头沟通交流，自愿加入本研究的患者。", "label": 5, "label_text": "Multiple", "id": "s4525"}
{"text": " 根据研究者判断，患者目前的状况不适合参加本项研究", "label": 21, "label_text": "Researcher Decision", "id": "s4526"}
{"text": " 5.有精神疾病，或者精神类药物滥用史；", "label": 5, "label_text": "Multiple", "id": "s4527"}
{"text": " 2、伴有颅内出血或其他无法控制的出血症状的患者；", "label": 5, "label_text": "Multiple", "id": "s4528"}
{"text": " 3.已知造影剂过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4529"}
{"text": " 未签署知情同意者", "label": 13, "label_text": "Consent", "id": "s4530"}
{"text": " （5）过敏体质者或对治疗药物已知有过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4531"}
{"text": " 10. 在研究过程中可能使用其他营养产品的患者，如蛋白质粉、牛初乳等；", "label": 18, "label_text": "Diet", "id": "s4532"}
{"text": " 2) 年龄≥ 18 岁；", "label": 3, "label_text": "Age", "id": "s4533"}
{"text": " ⑨孕妇、引产、人流哺乳妇女及今后半年内可能怀孕的患者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4534"}
{"text": " 4.未服药或如果正在服用精神科药物,药物的种类和剂量保持稳定6周以上，且无调药计划；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4535"}
{"text": " 4.同意参加本研究，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4536"}
{"text": " 4)MTHFR基因检测为TT型", "label": 12, "label_text": "Laboratory Examinations", "id": "s4537"}
{"text": " 4.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4538"}
{"text": " 7)入选前三个月内，参加过另一药物试验或使用过本试验药物；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4539"}
{"text": " ②勃起功能国际量表(IIEF5) ＜22 分", "label": 9, "label_text": "Risk Assessment", "id": "s4540"}
{"text": " 4. 资料不全无法分析者。", "label": 22, "label_text": "Data Accessible", "id": "s4541"}
{"text": " (4)受试者在筛选访视前3个月内参加过献血或失血超过400ml。", "label": 5, "label_text": "Multiple", "id": "s4542"}
{"text": " (5)病程在8小时之内，有CT证实颅内出血;", "label": 11, "label_text": "Diagnostic", "id": "s4543"}
{"text": "1.有严重的运动、认知、情绪障碍，无法积极参与测试;", "label": 5, "label_text": "Multiple", "id": "s4544"}
{"text": " 4.最佳矫正视力小于0.5", "label": 12, "label_text": "Laboratory Examinations", "id": "s4545"}
{"text": " 4、存在其他临床原因需要输注20%白蛋白的情况（包括但不限于：肝硬化并腹水、小肠吸收不良综合征、肾病综合征、烧伤等）。", "label": 5, "label_text": "Multiple", "id": "s4546"}
{"text": " （2）ASAⅠ~Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s4547"}
{"text": "1) 受试者充分了解试验目的、性质、方法以及可能发生的不良反应，自愿作为受试者，并签署知情同意书，能够按照方案要求完成试验者。", "label": 5, "label_text": "Multiple", "id": "s4548"}
{"text": " 6、因高血压等疾病治疗期间须服用钙离子通道阻滞剂、血管紧张素转换酶抑制剂的等含降肺动脉高压的药物的；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4549"}
{"text": " （8）代偿失调的心功能不全或严重高血压或糖尿病患者，即收缩压高于160mmHg，或舒张压高于100mmHg；", "label": 5, "label_text": "Multiple", "id": "s4550"}
{"text": " 6. 妊娠期、哺乳期妇女和不能按要求进行避孕的育龄妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4551"}
{"text": "1．符合胃肠道肿瘤诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4552"}
{"text": " 7）明确的对试验药品或其制剂成份过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4553"}
{"text": " 13、颌骨发育不全或病理性改变；", "label": 4, "label_text": "Disease", "id": "s4554"}
{"text": " ③最近5年内有恶性肿瘤病史，除外已经治愈的皮肤基底细胞癌、浅表膀胱癌或子宫颈原位癌；", "label": 4, "label_text": "Disease", "id": "s4555"}
{"text": "(1)病人对丙泊酚中/长链脂肪乳过敏，或对大豆、花生或赋形剂中任何成份过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4556"}
{"text": " f.育龄妇女必须在入组前行尿或血妊娠试验，且结果为阴性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4557"}
{"text": " ⑦使用白蛋白、血浆等血液制品输注及采用肠外营养的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4558"}
{"text": "病人适合并愿意接受靶向治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4559"}
{"text": "1. 符合中国骨关节炎诊治指南（2007年版）制定的膝关节OA诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4560"}
{"text": " (2)影像检查提示腰椎椎弓根断裂；", "label": 11, "label_text": "Diagnostic", "id": "s4561"}
{"text": " ②中医辨证属于肝胃不和型、脾胃湿热型之一者。", "label": 11, "label_text": "Diagnostic", "id": "s4562"}
{"text": "1择期在全麻下行腹部手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4563"}
{"text": " （2）冠脉造影或冠脉CT检查发现有1支以上冠脉血管病变＜70%且≥25%；", "label": 11, "label_text": "Diagnostic", "id": "s4564"}
{"text": " 3)ECOG评分≤1分，预计生存期至少3个月；", "label": 5, "label_text": "Multiple", "id": "s4565"}
{"text": " 5.签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4566"}
{"text": " 11.正在参加其他药物临床研究的受试者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4567"}
{"text": "1. 正在参加其他临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4568"}
{"text": " 9.患有各系统恶性肿瘤者；", "label": 4, "label_text": "Disease", "id": "s4569"}
{"text": " 2.严重脊柱创伤史；", "label": 4, "label_text": "Disease", "id": "s4570"}
{"text": " 5.患者最佳矫正视力达到1.0或以上", "label": 12, "label_text": "Laboratory Examinations", "id": "s4571"}
{"text": " （5）常规治疗（外用中强效糖皮质激素或免疫调节剂等）不能有效控制病情；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4572"}
{"text": " 6.如果是处于性活跃期的男性受试者，若没有行输精管切除术且其配偶具有生育能力，则必须同意采用经研究者认可的合适的避孕措施（例如，输精管切除术、双重屏障方法、其配偶采用有效的避孕方法），并且在研究期间以及末次研究药物给药后3个月内不得捐献精子。必须同意在研究期间以及末次研究药物给药后3个月内持续采取合适的避孕措施。", "label": 5, "label_text": "Multiple", "id": "s4573"}
{"text": " （3）患者需要急诊手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4574"}
{"text": " 健康成人组", "label": 32, "label_text": "Healthy", "id": "s4575"}
{"text": " 3.SLE病史6个月以上", "label": 4, "label_text": "Disease", "id": "s4576"}
{"text": " 3、证实具有临床意义的实验室检查结果；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4577"}
{"text": " 4、大量胸腔积液或心包积液；", "label": 1, "label_text": "Sign", "id": "s4578"}
{"text": " (8)妊娠期、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4579"}
{"text": " 7)血生化指标：肝功能：胆红素≤正常上限1.5倍，AST≤正常上限2.5倍；血清肌酐≤正常上限1.5倍；血钙浓度：≤12.0 mg/dL；", "label": 5, "label_text": "Multiple", "id": "s4580"}
{"text": " （3）根据原发性肝癌诊疗规范（2017年版）临床分期为Ib、IIa期HCC；", "label": 11, "label_text": "Diagnostic", "id": "s4581"}
{"text": " 2 活动性移植物抗宿主病", "label": 4, "label_text": "Disease", "id": "s4582"}
{"text": " 21.过去2年内存在导致末端器官损伤或需要全身免疫抑制/全身疾病调节药物的自身免疫性疾病（如，克罗恩氏病、类风湿性关节炎、系统性红斑狼疮）病史；", "label": 5, "label_text": "Multiple", "id": "s4583"}
{"text": "（1）严重心脏瓣膜疾病、周围血管疾病、射血分数低于40％的患者；", "label": 5, "label_text": "Multiple", "id": "s4584"}
{"text": " 11)根据研究者的判断，有严重的危害患者安全或影响患者完成研究的伴随疾病的患者；", "label": 21, "label_text": "Researcher Decision", "id": "s4585"}
{"text": " （9）严重的心、肺、肾等相关疾病。", "label": 4, "label_text": "Disease", "id": "s4586"}
{"text": " 12.患者/亲属/监护人对本研究缺乏基本的依从性的。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4587"}
{"text": " 既往无盆腔器官脱垂手术史", "label": 0, "label_text": "Therapy or Surgery", "id": "s4588"}
{"text": " 3、 合并继发性或原发性各系统靶器官严重病变、 精神病、 肿瘤", "label": 4, "label_text": "Disease", "id": "s4589"}
{"text": " (3) 身高150～175cm；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4590"}
{"text": " (3)受试者已接受或即将接受全身性或局部性化疗或放疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4591"}
{"text": " 5.  3个月前已参加其他类似研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4592"}
{"text": " 4.预期生存期≥3个月", "label": 23, "label_text": "Life Expectancy", "id": "s4593"}
{"text": "（1）ST段抬高型心肌梗死患者", "label": 4, "label_text": "Disease", "id": "s4594"}
{"text": " （7）他克莫司敏感者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4595"}
{"text": " （12）患者在过去1月内曾因消化道出血住院或输血，或者有其它临床上显著的出血倾向或凝血障碍导因而不能接受所需的抗血小板治疗，或患者拒绝输血", "label": 5, "label_text": "Multiple", "id": "s4596"}
{"text": " ④严重的心、肺、肝、肾等躯体疾病或严重的神经精神疾病。", "label": 4, "label_text": "Disease", "id": "s4597"}
{"text": "（1）1型糖尿病；", "label": 4, "label_text": "Disease", "id": "s4598"}
{"text": " 2）拟行MSCs治疗前60天内，接受过免疫治疗(包括局部糖皮质激素治疗≥1周)或化学药物治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4599"}
{"text": " 4. 四肢缺陷；", "label": 4, "label_text": "Disease", "id": "s4600"}
{"text": " （6）研究开始前4周内未接受过化疗、放疗、分子靶向治疗、中药治疗以及手术，并已从之前治疗的急性毒性反应中恢复，脱发以及外周神经毒性除外；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4601"}
{"text": " 14)研究者认为不适合参加本研究。", "label": 21, "label_text": "Researcher Decision", "id": "s4602"}
{"text": " 4. 不能按照规定来用药，或者工作环境等经常变动等易造成失访的患者，或者未达到设定的观察周期而放弃治疗，无法判定药物治疗效果，或者相关材料不全的患者；", "label": 5, "label_text": "Multiple", "id": "s4603"}
{"text": " 4.知情同意，自愿受试并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4604"}
{"text": " 11.能按方案要求随访疗效及不良反应；预计依从性好者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4605"}
{"text": " 15.存在CNS病史或疾病，如癫痫发作疾病、脑血管缺血/出血、痴呆、小脑疾病，或任何涉及CNS的自身免疫性疾病；", "label": 4, "label_text": "Disease", "id": "s4606"}
{"text": " 6.ECOG评分0-2分", "label": 9, "label_text": "Risk Assessment", "id": "s4607"}
{"text": "1、妊娠期AP；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4608"}
{"text": " 6）病程3个月内。", "label": 4, "label_text": "Disease", "id": "s4609"}
{"text": "1.体外循环心脏手术后即刻入住ICU患者；", "label": 5, "label_text": "Multiple", "id": "s4610"}
{"text": " 7)妊娠试验阳性者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4611"}
{"text": " (2)麻醉風險分級為I到II (ASA class I-II)", "label": 9, "label_text": "Risk Assessment", "id": "s4612"}
{"text": " （3）各项生命体征均平稳且平稳时间超过24小时。", "label": 1, "label_text": "Sign", "id": "s4613"}
{"text": "(1)符合卫生部《手足口病诊疗指南2010年版》诊断标准的手足口病Ⅰ期患者；", "label": 11, "label_text": "Diagnostic", "id": "s4614"}
{"text": " 9.受试者在入组前的6个月内接受了电休克疗法(ECT)；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4615"}
{"text": "1.术中发现无明显假膜者；", "label": 1, "label_text": "Sign", "id": "s4616"}
{"text": " 2、排除肝肾联合及二次移植者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4617"}
{"text": " ③至少患有高血压、高血脂、冠心病、脑梗死、糖尿病五种疾病中的一种。", "label": 4, "label_text": "Disease", "id": "s4618"}
{"text": " 6） 已接触过相同的神经心理学量表者；", "label": 9, "label_text": "Risk Assessment", "id": "s4619"}
{"text": " （4）自愿参加，并能够配合并坚持随访；", "label": 5, "label_text": "Multiple", "id": "s4620"}
{"text": " 2. 具有下肢动脉阻塞性疾病的相关临床症状，包括跛行，静息痛及足趾坏疽。", "label": 5, "label_text": "Multiple", "id": "s4621"}
{"text": " 2.年龄在18~65岁之间，男女不限，包括住院及门诊患者；", "label": 5, "label_text": "Multiple", "id": "s4622"}
{"text": " （6）知情同意，志愿受试。获得知情同意书过程应符合GCP 规定。", "label": 13, "label_text": "Consent", "id": "s4623"}
{"text": " ④有活动性炎症和眼表疾病，有严重的眼附属器病变及眼部器质性病变；", "label": 4, "label_text": "Disease", "id": "s4624"}
{"text": " CE3.30天内曾发生急性心肌梗死（Q波MI,或非Q波MI伴有肌酸激酶同工酶，肌钙蛋白T升高）", "label": 5, "label_text": "Multiple", "id": "s4625"}
{"text": "1）年龄≥18周岁", "label": 3, "label_text": "Age", "id": "s4626"}
{"text": " ⑩ 精神障碍患者；", "label": 4, "label_text": "Disease", "id": "s4627"}
{"text": " 13. 预计寿命不超过3年的；和合并颅内或颅外恶性肿瘤者；合并恶性肿瘤者；合并心脏、肝脏、肾脏、肺等重要脏器疾病或功能衰竭者；", "label": 5, "label_text": "Multiple", "id": "s4628"}
{"text": " （10）严重肾脏疾病，肌酐清除率＜30ml/min，血清肌酐＞133umol/L", "label": 5, "label_text": "Multiple", "id": "s4629"}
{"text": "1.脑血管病、桥小脑角、颞骨、侧颅底、腮腺良恶性肿瘤等造成的面神经麻痹者；", "label": 4, "label_text": "Disease", "id": "s4630"}
{"text": " 12. 自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4631"}
{"text": " （9）呼吸系统疾病患者,如慢性支气管炎、肺气肿以及支气管扩张肺功能不全；", "label": 5, "label_text": "Multiple", "id": "s4632"}
{"text": " 3. 孕妇、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4633"}
{"text": " （4）恶性高热患者", "label": 4, "label_text": "Disease", "id": "s4634"}
{"text": " ②不吸烟或者戒烟1年以上者；", "label": 36, "label_text": "Smoking Status", "id": "s4635"}
{"text": " （2）视听功能差，不能听从运动引导；", "label": 5, "label_text": "Multiple", "id": "s4636"}
{"text": "    ④合并恶性肿瘤者", "label": 4, "label_text": "Disease", "id": "s4637"}
{"text": "1) 符合Parks I 型肛瘘诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s4638"}
{"text": " ⑦ 术前有酗酒或吸毒史;", "label": 2, "label_text": "Addictive Behavior", "id": "s4639"}
{"text": "健康志愿者排除标准：", "label": 32, "label_text": "Healthy", "id": "s4640"}
{"text": " 2）术前接受任何辅助放化疗或其他抗肿瘤治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4641"}
{"text": " （3）肥胖患者（体重指数&gt;28kg/m2）；", "label": 5, "label_text": "Multiple", "id": "s4642"}
{"text": " 配方粉A（伊利金领冠奶粉）组：母亲因各种疾病而不能母乳喂养，签署知情同意书愿意应用本项目所提供配方粉A进行喂养4个月以上的足月儿。", "label": 5, "label_text": "Multiple", "id": "s4643"}
{"text": "⑴OSAHS外合并有其他系统疾病的综合征患者。", "label": 4, "label_text": "Disease", "id": "s4644"}
{"text": " 11)有器官移植病史。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4645"}
{"text": " 3.急性荨麻疹，免疫性或物理性荨麻疹，血管炎患者；", "label": 4, "label_text": "Disease", "id": "s4646"}
{"text": "（1）Qmax＞20ml/s；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4647"}
{"text": " 3.有眼部炎症反应、过敏及其他眼病的患者", "label": 5, "label_text": "Multiple", "id": "s4648"}
{"text": " 7 合并严重心（充血性心力衰竭，心源性休克等）、脑血管疾病，合并肝、肾及造血系统等严重原发性疾病（ALT、AST、BUN高于正常值上限2倍，或Cr高于正常值上限）。", "label": 5, "label_text": "Multiple", "id": "s4649"}
{"text": " 3.甲胎蛋白大于200ng/ml；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4650"}
{"text": "1.合并有其他可能导致膝关节疼痛的患者，例如痛风、风湿或类风湿性关节炎等", "label": 4, "label_text": "Disease", "id": "s4651"}
{"text": " 3)  治疗前出现2级或以上的末梢神经病变或疼痛；", "label": 28, "label_text": "Symptom", "id": "s4652"}
{"text": " 1.  腔隙性脑梗死、短暂性脑缺血发作(TIA)；", "label": 4, "label_text": "Disease", "id": "s4653"}
{"text": " 2、月经周期规律，25-35天", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4654"}
{"text": " 8、存在影响体外反搏治疗的心律失常；", "label": 5, "label_text": "Multiple", "id": "s4655"}
{"text": " ⑤凝血功能不全的患者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4656"}
{"text": " 2、收缩压≤90mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4657"}
{"text": " 11.近一个月接受MECT、rTMS治疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4658"}
{"text": " 8. 对试验药已知成分过敏或过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4659"}
{"text": " 5)达到HCG注射日的标准(两个主导卵泡直径≥18mm)。", "label": 5, "label_text": "Multiple", "id": "s4660"}
{"text": " （10）术前情绪过度紧张者；", "label": 28, "label_text": "Symptom", "id": "s4661"}
{"text": "实验组：排除有风湿活动、免疫性疾病、和半年内应用免疫抑制剂的患者，排除存在术前贫血、肿瘤，排除近期感染及临床数据收集不全影响结果判定的患者。", "label": 5, "label_text": "Multiple", "id": "s4662"}
{"text": " 5）有可能会干扰参与研究的伴随疾病或状况，或有任何可能影响受试者安全的严重医学障碍（例如，不可控的心脏疾病、高血压，活动性或无法控制的感染、活动性乙肝病毒感染）；", "label": 4, "label_text": "Disease", "id": "s4663"}
{"text": " ⑻正在参加其他临床试验的受试者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4664"}
{"text": " 3.,神经肌肉系统疾患：多发性硬化症、重症肌无力、萎缩性肌强直等；", "label": 4, "label_text": "Disease", "id": "s4665"}
{"text": " 6)患者自愿参加本研究并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4666"}
{"text": " 3. 同时患有其它血液系统疾病。", "label": 4, "label_text": "Disease", "id": "s4667"}
{"text": " （3）严重电解质紊乱者；", "label": 1, "label_text": "Sign", "id": "s4668"}
{"text": "1)男性或女性，年龄18-70岁；", "label": 5, "label_text": "Multiple", "id": "s4669"}
{"text": " 2.调查期间未在岗的护士；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s4670"}
{"text": " 5、 有以下眼部疾病病史：高度近/远视、慢性葡萄膜炎及其他眼部炎症病史、异常虹膜、青光眼、视网膜脱离及其他视网膜疾病、神经眼科疾病等；", "label": 4, "label_text": "Disease", "id": "s4671"}
{"text": " 2.行根治性放射治疗，靶区含鼻咽及颈部淋巴引流区；", "label": 5, "label_text": "Multiple", "id": "s4672"}
{"text": " 6. 器官及骨髓功能正常，定义如下：白细胞计数 ≥4, 000/μL，血红蛋白≥9 g/dL (未输血的情况下)，中性粒细胞计数 ≥2, 100/μL，血小板计数 ≥100, 000/μL，总胆红素&lt; 1.5 倍正常值上限，AST (SGOT)/ALT (SGPT) ≤2.5 倍正常值上限，血肌酐 ≤ 1.5倍正常值上限。", "label": 5, "label_text": "Multiple", "id": "s4673"}
{"text": " 15.正在接受其他试验性药物或仪器试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4674"}
{"text": " 1)年龄在18-45周岁的中国健康志愿者，同批年龄相差＜10岁，男女各半；", "label": 5, "label_text": "Multiple", "id": "s4675"}
{"text": "  4. 近6个月内有心肌梗死或心力衰竭史。", "label": 4, "label_text": "Disease", "id": "s4676"}
{"text": "1.合并其他肿瘤或以下全身系统疾病：严重凝血功能障碍、重要脏器功能失代偿者、无法控制的严重的心身疾病。", "label": 5, "label_text": "Multiple", "id": "s4677"}
{"text": " (10)有幽闭恐惧症等无法接受fMRI检查者（仅参加功能磁共振扫描的受试者）；", "label": 5, "label_text": "Multiple", "id": "s4678"}
{"text": " 5. 病史显示存在急性、慢性肝炎或乙肝病毒携带者", "label": 4, "label_text": "Disease", "id": "s4679"}
{"text": " 5.中医辨证属于气虚血瘀或阴虚血涩证。", "label": 11, "label_text": "Diagnostic", "id": "s4680"}
{"text": " ②BMI&lt;28kg/m2；", "label": 9, "label_text": "Risk Assessment", "id": "s4681"}
{"text": "(1) 符合股骨头坏死诊断标准，ARCO分期为Ⅰ－Ⅳ期；", "label": 11, "label_text": "Diagnostic", "id": "s4682"}
{"text": " 9.身体健康，无心脏病、严重呼吸系统疾病等其他病史", "label": 4, "label_text": "Disease", "id": "s4683"}
{"text": " 5.术前及术后行颅脑及肺部CT检查。", "label": 34, "label_text": "Device", "id": "s4684"}
{"text": "  2.既往使用过靶向药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4685"}
{"text": " （6）有ART及妊娠的禁忌症，或患有对妊娠有明确影响的疾病的患者，如高血压、有临床症状的心脏病、糖尿病、肝脏疾病、肾脏疾病、重度贫血、静脉血栓史、肺栓塞或脑血管事件史、恶性肿瘤病史；", "label": 4, "label_text": "Disease", "id": "s4686"}
{"text": "1、根据CT检查Lund-Mackay评分多6分的慢性鼻窦炎房·息肉者需要鼻内窥镜手术治疗者", "label": 5, "label_text": "Multiple", "id": "s4687"}
{"text": " （4）VAS肩关节疼痛评分&lt;6；", "label": 9, "label_text": "Risk Assessment", "id": "s4688"}
{"text": " ③胃肠道功能正常，无其他系统疾病；", "label": 5, "label_text": "Multiple", "id": "s4689"}
{"text": " 研究者判断为不适合参加本研究的其他患者。", "label": 21, "label_text": "Researcher Decision", "id": "s4690"}
{"text": " 5.合并眼球震颤", "label": 4, "label_text": "Disease", "id": "s4691"}
{"text": " 4) 有症状的心动过缓或低血压（心率&lt;50次/分，血压&lt;90/60mmHg）；", "label": 5, "label_text": "Multiple", "id": "s4692"}
{"text": " (3) 急诊颅脑手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s4693"}
{"text": " 2.因术中大血管损伤、周围组织器官损伤引起大出血等引起手术时间延长的病例；", "label": 5, "label_text": "Multiple", "id": "s4694"}
{"text": " 2. 对阿帕替尼、紫杉醇、顺铂等药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4695"}
{"text": " ⑶间歇性外斜视术后1-2月内，双眼正位，内斜斜视度≦5△或外斜斜视度＜15△者；", "label": 5, "label_text": "Multiple", "id": "s4696"}
{"text": " 8）神经肌肉疾病患者；", "label": 4, "label_text": "Disease", "id": "s4697"}
{"text": " ⑦TNM分期为I期；", "label": 24, "label_text": "Neoplasm Status", "id": "s4698"}
{"text": " 6. 参加前签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4699"}
{"text": " 2.需要植骨的病例包括：", "label": 0, "label_text": "Therapy or Surgery", "id": "s4700"}
{"text": " 6、患者/法定代理人签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4701"}
{"text": "（1）因卵巢局部手术引起者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4702"}
{"text": " （3）对针灸治疗畏惧、晕针，不能坚持治疗者。", "label": 5, "label_text": "Multiple", "id": "s4703"}
{"text": " （9）根据医生判断容易造成失访者。", "label": 21, "label_text": "Researcher Decision", "id": "s4704"}
{"text": " 8.合并其他运动可能加重的神经、肌肉、骨骼肌、风湿性疾病；", "label": 4, "label_text": "Disease", "id": "s4705"}
{"text": " 2、入组前2周内使用过任何抗肿瘤治疗，除外以上提及的单一剂量鞘注及为治疗高白细胞血症而使用的羟基尿或阿糖胞苷；", "label": 5, "label_text": "Multiple", "id": "s4706"}
{"text": " d.每个受试者必须签署知情同意书（ICF），表明他/她理解研究的目的和程序，而且愿意参与研究；从患者的病情考虑，若患者本人签字不利于病情治疗，则由法定代表签署ICF。", "label": 13, "label_text": "Consent", "id": "s4707"}
{"text": "（1）本院确诊为子宫内膜息肉、宫腔粘连等宫腔内病变患者；", "label": 4, "label_text": "Disease", "id": "s4708"}
{"text": " 3.年龄45~60岁；", "label": 3, "label_text": "Age", "id": "s4709"}
{"text": "（1）符合以上脑卒中及睡眠障碍的中西医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4710"}
{"text": " Hunt-Hess分级为IV-V级", "label": 9, "label_text": "Risk Assessment", "id": "s4711"}
{"text": " （4）由子宫内膜结核、脑垂体瘤、甲状腺疾病等引起的月经过少者；", "label": 5, "label_text": "Multiple", "id": "s4712"}
{"text": " （5）合并颅脑外伤或恶性肿瘤者；", "label": 4, "label_text": "Disease", "id": "s4713"}
{"text": " 4. 既往有精神疾病史或服用抗精神病药物病史；", "label": 5, "label_text": "Multiple", "id": "s4714"}
{"text": " 9. 5年内患有其他恶性肿瘤的患者；", "label": 4, "label_text": "Disease", "id": "s4715"}
{"text": " ⑦经过研究者判断，可能危及到受试者安全，影响方案依从性或试验结果评价的任何其它情况", "label": 21, "label_text": "Researcher Decision", "id": "s4716"}
{"text": " 4 对已知的药物成份过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4717"}
{"text": "(1)近半年内曾应用激素、免疫抑制剂和/或雷公藤多苷片。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4718"}
{"text": " d. 有中心静脉置管者与动脉导管的患者；", "label": 34, "label_text": "Device", "id": "s4719"}
{"text": " ②存在严重言语、视力、听力障碍、精神或情绪障碍等影响认知检查；", "label": 4, "label_text": "Disease", "id": "s4720"}
{"text": " 4.经头颅CT或MRI检查证实；", "label": 11, "label_text": "Diagnostic", "id": "s4721"}
{"text": " 7.具备单采或者静脉采血足够的静脉通路，并且没有其他的血球分离禁忌症", "label": 4, "label_text": "Disease", "id": "s4722"}
{"text": " 1. 组织病理学证实非宫颈鳞癌、腺癌或腺鳞癌者，若存在小细胞、神经内分泌癌、肉瘤成分，不可以入组；", "label": 11, "label_text": "Diagnostic", "id": "s4723"}
{"text": " 10)重度肥胖的小儿或早产儿纠正月龄未满六个月", "label": 4, "label_text": "Disease", "id": "s4724"}
{"text": "1.18岁以上，男女均可；", "label": 5, "label_text": "Multiple", "id": "s4725"}
{"text": " 对润湿液存在超敏反应或过敏反应。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4726"}
{"text": " 6. 从开始内分泌治疗至随机分组时间小于6个月；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4727"}
{"text": " （8）估计患者参加本临床研究的依从性不足。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4728"}
{"text": " （2）手术后至入组前曾使用治疗本病的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4729"}
{"text": " 5) 因各种原因不能按时就诊，复查的患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4730"}
{"text": " 2.哺乳期患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4731"}
{"text": " 基线FSH＞10IU/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s4732"}
{"text": " ②近1月内抗病毒治疗药物发生改变（包括新用、停止或改用其它药物）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4733"}
{"text": "1)中国健康受试者，男女均有，且女：男不低于1:2；", "label": 5, "label_text": "Multiple", "id": "s4734"}
{"text": " 5.既往有胃肠疾病或其他系统疾病可以影响胃肠动力者；", "label": 4, "label_text": "Disease", "id": "s4735"}
{"text": " 6.试验开始前2周更换药物和改变药物剂量的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4736"}
{"text": " (5)严重的精神障碍或既往精神疾病病史阳性者；", "label": 4, "label_text": "Disease", "id": "s4737"}
{"text": " ④术前认知功能正常", "label": 4, "label_text": "Disease", "id": "s4738"}
{"text": " 3）头部外伤史；", "label": 4, "label_text": "Disease", "id": "s4739"}
{"text": " 14)冠状动脉造影显示罪犯血管血流TIMI3级，且无明显血栓征象；", "label": 5, "label_text": "Multiple", "id": "s4740"}
{"text": " ⑹ 不签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s4741"}
{"text": " 10.过去3个月参加其它临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4742"}
{"text": " 3. 既往接受过盆腔放疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s4743"}
{"text": " ⑤有长期应用影响眼压的药物病史", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4744"}
{"text": " （7）不能配合研究的患者以及入ICU24小时内即发生死亡者,以及预计短期内死亡者（&lt;5天）；", "label": 5, "label_text": "Multiple", "id": "s4745"}
{"text": " (10)其他原因引起的肝病：包括慢性酒精性肝炎、药物性肝炎、自身免疫性肝炎（抗核抗体滴度高于 l:160）、肝豆状核变性（Wilson氏病）及血色病；", "label": 4, "label_text": "Disease", "id": "s4746"}
{"text": " 6.具有影响口服药物的多种因素（如无法吞咽、慢性腹泻和肠梗阻，明显影响药物服用和吸收的情况）；", "label": 5, "label_text": "Multiple", "id": "s4747"}
{"text": " 5、有出凝血功能障碍或抗凝药物史", "label": 5, "label_text": "Multiple", "id": "s4748"}
{"text": " （12）可能引起类似症状的风湿免疫类疾病患者；", "label": 4, "label_text": "Disease", "id": "s4749"}
{"text": " 3.股骨头坏死分期为II、III期。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s4750"}
{"text": " （7）凡不符合纳入标准，未按规定服用受试样品，或资料不全影响观察结果者。", "label": 5, "label_text": "Multiple", "id": "s4751"}
{"text": "1.自愿参加并书面签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s4752"}
{"text": " 18.受试者在给药前3月-给药前2天内使用过任何代谢诱导剂(如巴比妥酸盐、利福平等)。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4753"}
{"text": " 7)试验前3个月内参加献血且献血量&gt;400mL，或接受过输血；", "label": 5, "label_text": "Multiple", "id": "s4754"}
{"text": "（1）符合诊断标准，确诊为先天性心脏病患儿（一般通过症状、体征、心电图和超声心动图等即可作出诊断）；", "label": 11, "label_text": "Diagnostic", "id": "s4755"}
{"text": " 8)精神病患者，或无自知能力者；", "label": 5, "label_text": "Multiple", "id": "s4756"}
{"text": " (5)怀孕后可加重的患有心脏病患者。", "label": 5, "label_text": "Multiple", "id": "s4757"}
{"text": " 7）同时患有其它脏器恶性肿瘤", "label": 4, "label_text": "Disease", "id": "s4758"}
{"text": " 7. 已经列入计划的外科手术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4759"}
{"text": " 14）临床研究者认为参与临床研究的被试者不能配合治疗者。", "label": 21, "label_text": "Researcher Decision", "id": "s4760"}
{"text": " ②病程&gt;1个月；", "label": 4, "label_text": "Disease", "id": "s4761"}
{"text": " 2． 患者年龄≥18 周岁。", "label": 3, "label_text": "Age", "id": "s4762"}
{"text": " ANC ≥1.5×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4763"}
{"text": " 9)正在使用免疫抑制剂或全身性类固醇治疗（吸入治疗除外；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4764"}
{"text": "1.多量内出血，生命体征不稳定者;", "label": 1, "label_text": "Sign", "id": "s4765"}
{"text": " ⑤患者及家属对本研究知情同意。", "label": 13, "label_text": "Consent", "id": "s4766"}
{"text": " 5、恶性肿瘤，精神病患者；", "label": 4, "label_text": "Disease", "id": "s4767"}
{"text": " 6.依从性良好。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4768"}
{"text": " ④近期未参加其他临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s4769"}
{"text": " b.根据OABSS问卷表调查，患者尿急得分&gt;2、总得分&gt;3。", "label": 9, "label_text": "Risk Assessment", "id": "s4770"}
{"text": "1)病期较晚，超出入组要求", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s4771"}
{"text": " 2.符合糖尿病前期诊断标准 ( 1. 空腹血糖受损(IFG) FPG 5.6 ? 6.9 mmol/L 或2. 糖耐量降低(IGT) OGTT 2h PG7.8 - 11.0 mmol/L或3. A1C 5.7 - 6.4%)；", "label": 5, "label_text": "Multiple", "id": "s4772"}
{"text": " 4.重症全身性疾病、血液病、胶原病、结缔组织病、传染病、内分泌代谢性疾病的患者（糖尿病除外）。", "label": 4, "label_text": "Disease", "id": "s4773"}
{"text": " 拒绝行经口直接胆道镜检查或者不愿参加此项研究者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s4774"}
{"text": "1.继发性房角关闭 (UBM检查发现虹膜及虹膜后肿瘤、囊肿，葡萄膜炎，虹膜角膜内皮综合征及其他引起房角关闭的继发青光眼)；", "label": 4, "label_text": "Disease", "id": "s4775"}
{"text": " 2.年龄大于等于18岁；", "label": 3, "label_text": "Age", "id": "s4776"}
{"text": "（1）肝癌患者；", "label": 4, "label_text": "Disease", "id": "s4777"}
{"text": " 3、无脊柱生理曲度改变；", "label": 4, "label_text": "Disease", "id": "s4778"}
{"text": "（1）影像学证实为阑尾脓肿或穿孔", "label": 11, "label_text": "Diagnostic", "id": "s4779"}
{"text": "（1）有碘缺乏地区生活史，并且伴有甲状腺肿大", "label": 5, "label_text": "Multiple", "id": "s4780"}
{"text": "1.年龄满18周岁以上，性别不限；", "label": 5, "label_text": "Multiple", "id": "s4781"}
{"text": " 5、未取得患者家属同意", "label": 13, "label_text": "Consent", "id": "s4782"}
{"text": " ⑥患有乙肝等传染性疾病患者；", "label": 4, "label_text": "Disease", "id": "s4783"}
{"text": " 4.进展性恶性肿瘤或其它严重消耗性疾病，易合并感染及出血者；", "label": 4, "label_text": "Disease", "id": "s4784"}
{"text": " 22．胸片显示有活动性肺结核；或曾有结核病史或者潜伏性结核感染者或临床表现疑似为结核患者(包括但不限于肺结核)；", "label": 11, "label_text": "Diagnostic", "id": "s4785"}
{"text": " （6）严重贫血（Hb&lt;70g/l）。", "label": 4, "label_text": "Disease", "id": "s4786"}
{"text": " ⑧患类风湿性关节炎、强直性脊柱炎等自身免疫性疾病；", "label": 4, "label_text": "Disease", "id": "s4787"}
{"text": " （14）研究者认为任何不适合参加临床研究的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s4788"}
{"text": " 9、筛选期患有其它严重传染性疾病；", "label": 4, "label_text": "Disease", "id": "s4789"}
{"text": " CE5.患有不受控制的房颤", "label": 4, "label_text": "Disease", "id": "s4790"}
{"text": " 5.在基线之前的伴随疾病必须保持临床稳定状态；", "label": 4, "label_text": "Disease", "id": "s4791"}
{"text": "1.存在机械性肠梗阻的患者；", "label": 4, "label_text": "Disease", "id": "s4792"}
{"text": " 1.健康的成年人，年龄20～55岁；", "label": 3, "label_text": "Age", "id": "s4793"}
{"text": " 5.患者生命体征稳定：包括收缩压120-220mmHg之间、心率40-100次/分，指氧饱和度≥92%，体温≤38.5度", "label": 12, "label_text": "Laboratory Examinations", "id": "s4794"}
{"text": "(1）术中探查发现肿瘤有双侧肝内转移、远处脏器转移或腹腔内种植转移。", "label": 24, "label_text": "Neoplasm Status", "id": "s4795"}
{"text": " 同意参加本研究，并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4796"}
{"text": " 5）入选前4周内参加过或正在参加其他临床试验的患者", "label": 15, "label_text": "Enrollment in other studies", "id": "s4797"}
{"text": " 5. 只有一只手受伤；", "label": 4, "label_text": "Disease", "id": "s4798"}
{"text": "试验1：选择择期行胸科手术需进行肺隔离患者100例，术前签署麻醉以及试验知情同意书。", "label": 13, "label_text": "Consent", "id": "s4799"}
{"text": "（1）年龄18-70岁（≥18，≤70），男女均可；", "label": 5, "label_text": "Multiple", "id": "s4800"}
{"text": " 2)确诊为血脂异常伴颈动脉粥样硬化（血脂异常诊断标准参考2007年中国成人血脂异常防治指南制订联合委员会《中国成人血脂异常防治指南》，颈动脉粥样硬化参考颈动脉B超，即动脉内膜中层厚度(IMT)≥1.0mm，膨大处≥1.2mm或/和动脉粥样硬化斑块形成）；", "label": 5, "label_text": "Multiple", "id": "s4801"}
{"text": " 21.既往接受过TACE等局部治疗的患者，原病灶不可作为靶病灶，入组时必须有新的靶病灶", "label": 5, "label_text": "Multiple", "id": "s4802"}
{"text": " （3） 妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4803"}
{"text": " （6） 平均每天吸烟大于5支；", "label": 36, "label_text": "Smoking Status", "id": "s4804"}
{"text": " 4.凝血功能障碍（APPT超过正常值上限、INR&gt;1.4、血小板计数≤80×109/L)；", "label": 5, "label_text": "Multiple", "id": "s4805"}
{"text": " 5.牙列无明显菌斑沉积。", "label": 30, "label_text": "Oral related", "id": "s4806"}
{"text": " 3. 12～71月龄的双侧重度或极重度感音神经性聋患者；", "label": 5, "label_text": "Multiple", "id": "s4807"}
{"text": " 8)正在使用药物如钙通道阻滞剂，高剂量氨甲喋呤，合成雌激素，类固醇，胺碘酮，氯喹", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4808"}
{"text": " (5)理解并签署了知情同意书的自愿受试者。", "label": 13, "label_text": "Consent", "id": "s4809"}
{"text": "（1）伴有弱视", "label": 1, "label_text": "Sign", "id": "s4810"}
{"text": " （2）对伴有报警症状：不明原因的体重下降、肠癌或卵巢癌家族史、直肠出血、发热、贫血、腹部包块、直肠肿块；", "label": 5, "label_text": "Multiple", "id": "s4811"}
{"text": " 4. 无远处或椎管内播散转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s4812"}
{"text": " (11)无法正常沟通；", "label": 25, "label_text": "Literacy", "id": "s4813"}
{"text": " 4.目前怀孕、哺乳或计划在完成试验一个月内怀孕的患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4814"}
{"text": " 4.正在使用免疫抑制剂或免疫增强剂老人；不能配合调查者（痴呆、语言表达障碍、不能保证长期住在成都）；", "label": 5, "label_text": "Multiple", "id": "s4815"}
{"text": " 3、有应用非甾体抗炎药后发生胃肠出血或穿孔史的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4816"}
{"text": " 2.病程大于2年；", "label": 4, "label_text": "Disease", "id": "s4817"}
{"text": " （11）已知对于手术器械材质过敏，或过敏体质的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4818"}
{"text": " 6.任何不可控的活动性感染", "label": 4, "label_text": "Disease", "id": "s4819"}
{"text": " ①真性红细胞增多症：骨髓检查异常，JAK2阳性或EPO水平偏低或明显降低。", "label": 5, "label_text": "Multiple", "id": "s4820"}
{"text": " *注，如果TBUT≤5秒，则不必考虑入选标准6", "label": 12, "label_text": "Laboratory Examinations", "id": "s4821"}
{"text": "1.患有严重心、肝、肾等功能不全的疾病", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4822"}
{"text": " 3.最近30天内的≥二级的感染", "label": 4, "label_text": "Disease", "id": "s4823"}
{"text": " 11)有哮喘病史者；", "label": 4, "label_text": "Disease", "id": "s4824"}
{"text": " 4)曾患或现正并发其他恶性肿瘤者（除已治愈的基底或鳞状细胞皮肤癌或宫颈原位癌）；", "label": 4, "label_text": "Disease", "id": "s4825"}
{"text": " ②合并胃腺体萎缩、胃黏膜肠上皮化生属中度-重度或异型增生、胃癌、食管癌、胃出血者以及胆道、胰腺等器质性病变。", "label": 4, "label_text": "Disease", "id": "s4826"}
{"text": " 2) 生化检查需符合以下标准：TBIL＜1.5×ULN， ALT、AST＜2.5×ULN有肝转移患者可＜5×ULN，BUN和Cr≤1×ULN或内生肌酐清除率≥50ml/min（Cockcroft-Gault公式）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4827"}
{"text": " 3. 伴有活动性肺结核，痰菌涂片阳性；", "label": 4, "label_text": "Disease", "id": "s4828"}
{"text": " 3. 严重充血性心力衰竭；", "label": 4, "label_text": "Disease", "id": "s4829"}
{"text": " (4)踝关节外侧局部压痛；", "label": 1, "label_text": "Sign", "id": "s4830"}
{"text": " 4.过敏体质及对多种药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4831"}
{"text": " 4.伴心功能不全、肝功能损害、肾功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4832"}
{"text": " 2.中医辨证属于虚哮证。", "label": 11, "label_text": "Diagnostic", "id": "s4833"}
{"text": "1. 影像学检查示胆总管结石合并胆囊结石；", "label": 11, "label_text": "Diagnostic", "id": "s4834"}
{"text": " 3、1周内服用免疫抑制剂、激素、抗氧化剂、乌司他丁等药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4835"}
{"text": "1、特殊病因的支扩；", "label": 4, "label_text": "Disease", "id": "s4836"}
{"text": " 13.长期服用氯吡格雷患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4837"}
{"text": " ⑤服用质子泵抑制剂者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4838"}
{"text": " 3）有合并严重先天性疾病、严重心脏疾病病史患儿；", "label": 4, "label_text": "Disease", "id": "s4839"}
{"text": " e)研究者认为不应纳入者；", "label": 21, "label_text": "Researcher Decision", "id": "s4840"}
{"text": " (5)剖宫产；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4841"}
{"text": " 4.对非甾体类抗炎药过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4842"}
{"text": " ② 即将或正在接受IFN α1b的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4843"}
{"text": "1.1周内心肌梗死。", "label": 4, "label_text": "Disease", "id": "s4844"}
{"text": " 3)既往或合并患有其他恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s4845"}
{"text": " 3)最近5年存在药物或酒精滥用情况或有心理障碍；", "label": 5, "label_text": "Multiple", "id": "s4846"}
{"text": " 5. 使用胰岛素或艾塞那肽超过1个月", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4847"}
{"text": " 16.已知异体器官移植史或异体造血干细胞移植史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4848"}
{"text": "1.既往使用来那度来持续有效的多发性骨髓瘤患者，或已经使用三药治疗的患者", "label": 5, "label_text": "Multiple", "id": "s4849"}
{"text": " 2. 已证实对阿帕替尼和/或其辅料过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4850"}
{"text": " 1.2 ASA I—II级", "label": 9, "label_text": "Risk Assessment", "id": "s4851"}
{"text": " 3. 患甲状腺、肾脏、血液相关疾病，肝功能异常或感染性疾病者（肺结核、病毒性肝炎和HIV感染）；", "label": 5, "label_text": "Multiple", "id": "s4852"}
{"text": " 4.其他原因导致认知功能障碍，如：脑卒中患者；", "label": 4, "label_text": "Disease", "id": "s4853"}
{"text": "1.类风湿性关节炎和血友病关节炎", "label": 4, "label_text": "Disease", "id": "s4854"}
{"text": " 3、骨肉瘤一线化疗药物治疗失败者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4855"}
{"text": " 4. 有精神及心理疾病者；", "label": 4, "label_text": "Disease", "id": "s4856"}
{"text": " 3、2009.12－2010.10就诊于解放军总医院门诊，申请电子支气管镜检查的患者中：1)、胸部影像或临床高度怀疑肺癌的患者；或2)、吸烟指数&gt;=20包年(年龄&gt;=40岁)，有咳血、咳嗽等症状，胸部影像正常的患者。", "label": 5, "label_text": "Multiple", "id": "s4857"}
{"text": " 5）术前已知情同意并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s4858"}
{"text": " （4）伴有心、脑、肝、肾及内分泌、造血系统严重疾病者。", "label": 4, "label_text": "Disease", "id": "s4859"}
{"text": " ⑨有肩关节手术禁忌症；", "label": 4, "label_text": "Disease", "id": "s4860"}
{"text": " 3.因双侧手术难度不同，无法保证切口长度一致者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4861"}
{"text": " （6）既往无胃部手术史，无其他恶性肿瘤病史。", "label": 5, "label_text": "Multiple", "id": "s4862"}
{"text": " 5合并严重的心脑血管病、肝、肾和造血系统疾患；", "label": 4, "label_text": "Disease", "id": "s4863"}
{"text": " 12、怀疑或确有酒精、药物滥用史，或者根据研究者的判断、具有降低入组可能性或使入组复杂化的其他情况；", "label": 5, "label_text": "Multiple", "id": "s4864"}
{"text": "1、原发性开角型青光眼患者：1. 已有明确的原发性开角型青光眼诊断，有特征性的视乳头盘沿的变化、视神经纤维层损害、视野缺损。2. 最佳校正视力≥0.05。3.其中正常眼压青光眼患者没有接受过抗青光眼药物治疗或在本次检查前≥6周未点或全身应用抗青光眼药物，均接受24小时眼压日曲线检查，双眼未经治疗的自然眼压≤21mmHg IOP。", "label": 5, "label_text": "Multiple", "id": "s4865"}
{"text": " ③既往有重大精神疾病史，有嗜酒、吸毒及近半年内使用免疫抑制药物等。", "label": 5, "label_text": "Multiple", "id": "s4866"}
{"text": " 3）有严重心理问题无法配合研究者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4867"}
{"text": " 2.不配合治疗者及出院时拒绝参与继续治疗者。", "label": 5, "label_text": "Multiple", "id": "s4868"}
{"text": " ④吸烟量≧10支/天。", "label": 36, "label_text": "Smoking Status", "id": "s4869"}
{"text": " 2、合并继发性或原发性各系统靶器官严重病变、精神病、肿瘤患者", "label": 4, "label_text": "Disease", "id": "s4870"}
{"text": " ⑥妊娠及哺乳期女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4871"}
{"text": " （7）尿常规提示急慢性尿路感染；", "label": 11, "label_text": "Diagnostic", "id": "s4872"}
{"text": " 7.接受放化疗或激素治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4873"}
{"text": "  4.同意术后宫腔镜复查。", "label": 13, "label_text": "Consent", "id": "s4874"}
{"text": "1）年龄＜16岁或＞70岁者。", "label": 3, "label_text": "Age", "id": "s4875"}
{"text": " 18. 任何在参考范围以外的具有临床意义的实验室检查值；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4876"}
{"text": " 11.难以控制的高血压", "label": 4, "label_text": "Disease", "id": "s4877"}
{"text": "①青霉素阳性患者", "label": 12, "label_text": "Laboratory Examinations", "id": "s4878"}
{"text": " 2 知情同意并签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s4879"}
{"text": " 11）试验前3个月内使用过软毒品（如：摇头丸、KEN粉、麻古，等）或试验前一年内使用过硬毒品（如：可卡因、海洛因、冰毒，等）者；", "label": 2, "label_text": "Addictive Behavior", "id": "s4880"}
{"text": "1.病人拒绝；", "label": 13, "label_text": "Consent", "id": "s4881"}
{"text": " ⑤已知对本研究中所用药物过敏的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4882"}
{"text": " b)经细胞学或组织学确认的食管鳞状细胞癌，并需行手术治疗的实体瘤患者；", "label": 5, "label_text": "Multiple", "id": "s4883"}
{"text": " 5. 有能力并愿意遵守研究方案的要求；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4884"}
{"text": " ②合并妊娠（不包括产后）", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4885"}
{"text": " （2）有其他过敏性疾病，如：过敏性紫癜、哮喘", "label": 4, "label_text": "Disease", "id": "s4886"}
{"text": " 7.有严重未控制的内科疾病、急性感染者、近期皮肤过敏史；", "label": 5, "label_text": "Multiple", "id": "s4887"}
{"text": " 4. 以乳腺癌、肾癌、肝癌、肺癌、胃癌、结直肠癌为主；慢性乙型肝炎和HPV感染患者。", "label": 4, "label_text": "Disease", "id": "s4888"}
{"text": " 7.因相同病因再入院患者。", "label": 4, "label_text": "Disease", "id": "s4889"}
{"text": " 15) 已知对试验药品或相关产品过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4890"}
{"text": " d．受试者能理解和签署已被独立伦理委员会批准的知情同意书。注：也可由受试者合法授权代表提供知情同意。", "label": 5, "label_text": "Multiple", "id": "s4891"}
{"text": "1.年龄25-75岁之间；", "label": 3, "label_text": "Age", "id": "s4892"}
{"text": " （5） 术中因麻醉意外导致严重后果或死亡者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4893"}
{"text": " （2）、行口服葡萄糖耐量试验除外糖耐量异常或空腹血糖受损；", "label": 5, "label_text": "Multiple", "id": "s4894"}
{"text": "1）确诊的NSCLS", "label": 4, "label_text": "Disease", "id": "s4895"}
{"text": " 2.口腔卫生维护情况不佳（菌斑指数大于等于2的位点占测量位点20%以上，或有种植体周围粘膜炎者）。", "label": 30, "label_text": "Oral related", "id": "s4896"}
{"text": " 5.有驾驶行为、高空作业的患者。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s4897"}
{"text": " 8)根据术前造影资料预计能重建至少一根直达足底的膝下动脉，或患者合并糖尿病足。", "label": 0, "label_text": "Therapy or Surgery", "id": "s4898"}
{"text": " 3)SARA评分步态子项评分2-5分（含边界值）；能完成8MW试验；", "label": 5, "label_text": "Multiple", "id": "s4899"}
{"text": " （2）6个月内曾应用系统抗真菌药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4900"}
{"text": " 4. 患者同意加入本次临床研究，自愿签订了知情同意书，并同意按照研究方案的要求参加所有的访视、检查、治疗。", "label": 13, "label_text": "Consent", "id": "s4901"}
{"text": "1.年龄18-75岁之间，进展期胃癌患者；", "label": 5, "label_text": "Multiple", "id": "s4902"}
{"text": " ⑻根据研究者的判断、具有降低入组可能性或使入组复杂化的其他情况，工作环境经常变动等易造成失访的情况", "label": 21, "label_text": "Researcher Decision", "id": "s4903"}
{"text": " ③ 排除入组前使用抗精神病药物治疗者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4904"}
{"text": "1.经B 超及妇科检查，证实由于子宫内膜异位症、多囊卵巢综合征、子宫肌瘤、盆腔炎等疾病或其他因素引起的继发性痛经者；", "label": 11, "label_text": "Diagnostic", "id": "s4905"}
{"text": " 2.24 h尿蛋白定量0.5~2 g", "label": 12, "label_text": "Laboratory Examinations", "id": "s4906"}
{"text": " 4.预计生存期3个月以上；PS评分0-2分；", "label": 5, "label_text": "Multiple", "id": "s4907"}
{"text": " ③妊娠试验阳性者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4908"}
{"text": " 12)心电图异常有临床意义；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4909"}
{"text": "1. 5年内有其他恶性肿瘤病史", "label": 4, "label_text": "Disease", "id": "s4910"}
{"text": " 4)HLA相合同胞异基因造血干细胞移植;", "label": 0, "label_text": "Therapy or Surgery", "id": "s4911"}
{"text": " 6.患有先天性肾上腺皮质增生/皮质醇增多症/分泌雄激素的肿瘤/库欣综合征/甲状腺功能紊乱/促性腺激素低下/高催乳素血症疾病/早发性卵巢功能不全/ 功能性下丘脑性闭经/糖尿病", "label": 4, "label_text": "Disease", "id": "s4912"}
{"text": " (14) 近6个月内有药物滥用史或药物滥用筛查阳性者；", "label": 2, "label_text": "Addictive Behavior", "id": "s4913"}
{"text": " （2）受教育年限≥5年；", "label": 41, "label_text": "Education", "id": "s4914"}
{"text": " ④皮肤破溃或严重皮肤过敏患者。", "label": 5, "label_text": "Multiple", "id": "s4915"}
{"text": " 3.胃镜检查确诊为单纯性的活动性十二指肠溃疡（≥3mm且≤15mm，溃疡个数≤2，非线状和霜斑样溃疡）；", "label": 11, "label_text": "Diagnostic", "id": "s4916"}
{"text": " 6) 取得患者及家属的知情同意", "label": 13, "label_text": "Consent", "id": "s4917"}
{"text": "（1）妊娠期 、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4918"}
{"text": " 8.参加其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s4919"}
{"text": " 12.怀疑或确有酒精、药物滥用病史，或者根据研究者的判断、具有降低入组可能性或使入组复杂化的其他情况，如工作环境经常变动等易造成失访的情况。", "label": 5, "label_text": "Multiple", "id": "s4920"}
{"text": " ②具有严重影响预后的基础疾病，术前长期口服阿司匹林、凝血功能异常等影响手术效果的疾病；", "label": 5, "label_text": "Multiple", "id": "s4921"}
{"text": "第一诊断符合慢性心力衰竭（ICD-10码：I50.905）诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s4922"}
{"text": " 2.因脊柱或胸腹部脏器疾病需行胸腰椎或胸腹腔CT，同时怀疑是骨质疏松症，在3个月内行以DXA法行骨密度测量的患者；", "label": 5, "label_text": "Multiple", "id": "s4923"}
{"text": " 9.具有影响口服药物的多种因素（无法吞咽、胃肠道切除术后，慢性腹泻和肠梗阻等）；", "label": 5, "label_text": "Multiple", "id": "s4924"}
{"text": "1.妊娠或哺乳期妇女;", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4925"}
{"text": "（1） 有原发病（如恶性肿瘤、自身免疫性疾病、感染性疾病、结核、艾滋病、慢性活动性肝炎、慢性炎症性疾病、神经肌肉疾病、内分泌疾病，呼吸、循环和消化道疾病等）可以解释的慢性疲劳者；", "label": 4, "label_text": "Disease", "id": "s4926"}
{"text": " （2）美国麻醉医师协会（ASA）分级为I－III级；", "label": 9, "label_text": "Risk Assessment", "id": "s4927"}
{"text": " 11.妊娠或哺乳；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4928"}
{"text": " 5、资料不完整予以排除。", "label": 22, "label_text": "Data Accessible", "id": "s4929"}
{"text": " （6）合并胆道或胃肠道疾病，如胃溃疡、胰腺炎、克罗恩病、急性胃肠炎、胆道梗阻、胆囊炎、寄生虫感染等可能影响肠道菌群疾病；", "label": 4, "label_text": "Disease", "id": "s4930"}
{"text": " b)凝血功能障碍、心肺功能不全等外科手术禁忌者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s4931"}
{"text": " 5.体温高于38℃", "label": 12, "label_text": "Laboratory Examinations", "id": "s4932"}
{"text": "（1）已通过组织病理学或细胞学确诊的肺癌胸腔积液；", "label": 11, "label_text": "Diagnostic", "id": "s4933"}
{"text": " 4.KPS评分80分以上", "label": 9, "label_text": "Risk Assessment", "id": "s4934"}
{"text": " ② 经治疗后，依据PEDIS分级系统中的感染分级，感染依旧为4级的患者；", "label": 5, "label_text": "Multiple", "id": "s4935"}
{"text": " （7）经双肾CT平扫+增强或彩超检查提示1级单纯性肾囊肿&lt;40mm。", "label": 11, "label_text": "Diagnostic", "id": "s4936"}
{"text": "（1）反复自然流产2次及以上的患者（包括生化妊娠流产）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4937"}
{"text": " 9. 严重的肾功能不全、甲状腺功能异常或甲状腺结节、肾病综合症；", "label": 5, "label_text": "Multiple", "id": "s4938"}
{"text": " 3.酒精过敏，硝酸酯类药物禁用及慎用者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4939"}
{"text": " （4）肝脏肿瘤累积&gt;50%；", "label": 4, "label_text": "Disease", "id": "s4940"}
{"text": " 6、入组前4周内出现≥CTCAE 3级的出血；", "label": 9, "label_text": "Risk Assessment", "id": "s4941"}
{"text": " 4、一线化疗，如果患者曾经接受新辅助化疗或辅助化疗，则化疗结束时间距本研究入组≥6月；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4942"}
{"text": " 11.已知有酒精或药物依赖；", "label": 2, "label_text": "Addictive Behavior", "id": "s4943"}
{"text": " ②患者临床资料完整，包括年龄、性别、体质量指数、不良反应及相关血液指标检查结果(如血小板相关参数和淋巴细胞计数)等；", "label": 22, "label_text": "Data Accessible", "id": "s4944"}
{"text": " 4)无急性牙周感染。例如：脓肿、化脓、严重的肿胀和自发性出血。", "label": 5, "label_text": "Multiple", "id": "s4945"}
{"text": "1.符合脑梗死诊断标准，但经过溶栓或手术治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s4946"}
{"text": " 5）无饮酒史或既往（长期、持续性饮酒≧5年）女性平均纯酒精摄入&lt;10g/天，男性平均纯酒精摄入&lt;20g/天。", "label": 39, "label_text": "Alcohol Consumer", "id": "s4947"}
{"text": " 4.肾功能：血肌酐≤150 umol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4948"}
{"text": " （5）合并有胃肠道症状（如便秘、腹泻等）；", "label": 28, "label_text": "Symptom", "id": "s4949"}
{"text": " 5.严重精神发育迟缓", "label": 4, "label_text": "Disease", "id": "s4950"}
{"text": "1. 符合SLE诊断标准及中医肾虚瘀毒证辨证标准者。", "label": 11, "label_text": "Diagnostic", "id": "s4951"}
{"text": " 2.合并脑肿瘤、脑外伤、脑寄生虫病等患者。", "label": 4, "label_text": "Disease", "id": "s4952"}
{"text": "合并其他肝炎病毒、人类免疫缺陷病毒（human immunodeficiency virus，HIV）感染的患者；", "label": 4, "label_text": "Disease", "id": "s4953"}
{"text": " 7、激素替代治疗禁忌症；", "label": 4, "label_text": "Disease", "id": "s4954"}
{"text": " 5.手术和放疗开始时间间隔大于8个月；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4955"}
{"text": " 9.免疫性疾病或代谢综合征；", "label": 4, "label_text": "Disease", "id": "s4956"}
{"text": "1：急性重症鼻咽喉部疾病患者；", "label": 4, "label_text": "Disease", "id": "s4957"}
{"text": " 2）临床症状和影像学表现以外侧间室或髌股关节间隙为主", "label": 5, "label_text": "Multiple", "id": "s4958"}
{"text": " （2）诊断符合RA；", "label": 11, "label_text": "Diagnostic", "id": "s4959"}
{"text": " b.完善相关免疫系统检测；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4960"}
{"text": " 7. 身体内有使用医疗设备（如心脏起搏器等）。", "label": 34, "label_text": "Device", "id": "s4961"}
{"text": " 4．心理、家庭、社会等因素导致无知情同意者", "label": 13, "label_text": "Consent", "id": "s4962"}
{"text": "（1）合并盆腔急慢性炎症或子宫内膜异位症、子宫腺肌症、男方精液异常等其他可能导致不孕的因素；", "label": 5, "label_text": "Multiple", "id": "s4963"}
{"text": " 6.入组前完善头颈部病变部位CT，MRI及全身PET-CT，淋巴结检查及内镜检查；", "label": 34, "label_text": "Device", "id": "s4964"}
{"text": " （2）年龄在18-75岁之间；", "label": 3, "label_text": "Age", "id": "s4965"}
{"text": " 3、已知或怀疑对益生菌过敏。", "label": 7, "label_text": "Allergy Intolerance", "id": "s4966"}
{"text": " C.肝功能异常，定义为AST＞1.5xULN和/或ALT＞1.5xULN 和/或总胆红素＞1.5xULN", "label": 5, "label_text": "Multiple", "id": "s4967"}
{"text": "排除肺炎等其他呼吸系统疾病;", "label": 4, "label_text": "Disease", "id": "s4968"}
{"text": " 2.预计手术时间超过60分钟；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4969"}
{"text": " 4.存在难以纠正的高钾血症、心力衰竭等紧急透析指征者；", "label": 4, "label_text": "Disease", "id": "s4970"}
{"text": "1、确诊溃疡性结肠炎患者，且处于临床缓解期", "label": 5, "label_text": "Multiple", "id": "s4971"}
{"text": " ⑤3mg/L&lt;超敏C反应蛋白≤15mg/L。", "label": 12, "label_text": "Laboratory Examinations", "id": "s4972"}
{"text": " 12)同意24周的检查计划及随访计划，并积极配合；", "label": 8, "label_text": "Compliance with Protocol", "id": "s4973"}
{"text": "（1）计划妊娠妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s4974"}
{"text": " （10）入选前1个月内口服糖皮质激素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4975"}
{"text": " （5）自愿签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s4976"}
{"text": " （4）所有在近期内发生心血管事件者；", "label": 4, "label_text": "Disease", "id": "s4977"}
{"text": "1. 任何异常且有临床意义的医学检查发现", "label": 12, "label_text": "Laboratory Examinations", "id": "s4978"}
{"text": " 入组前完善颈部增强CT，MRI及内镜检查；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4979"}
{"text": " 2.术前接受CTA与GFR肾图检查，GFR肾图检查前2周内未接受具有肾脏毒性药物治疗或检查（包括但不限于碘造影剂）；", "label": 5, "label_text": "Multiple", "id": "s4980"}
{"text": " ④对本治疗中所用生物制剂过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s4981"}
{"text": " C、对CAP照射的凝胶有不适反应的患者；", "label": 5, "label_text": "Multiple", "id": "s4982"}
{"text": " C.病情程度为轻度AD，即简易精神状态量表（MMSE）总分=15分-26分（小学文化程度受试者15分-22分）；", "label": 5, "label_text": "Multiple", "id": "s4983"}
{"text": " （4）用药前完成常规体检项目,结果无明显异常者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s4984"}
{"text": " 7）ASA分级≥Ⅳ级。", "label": 9, "label_text": "Risk Assessment", "id": "s4985"}
{"text": "i 蛛网膜下腔出血、短暂性脑缺血发作，或合并其他颅内病变如颅内肿瘤、动脉瘤、血管畸形、脑囊虫病、脑内血吸虫病、脑炎、脑膜炎、脑积水、脑外伤后遗症者；", "label": 4, "label_text": "Disease", "id": "s4986"}
{"text": " 7）重度营养不良患者，血清白蛋白＜21g/L；前白蛋白＜ 0.10g/L。", "label": 5, "label_text": "Multiple", "id": "s4987"}
{"text": "1. 在进行任何的研究程序之前签署知情同意书", "label": 13, "label_text": "Consent", "id": "s4988"}
{"text": "1. 急性闭角型青光眼临床确诊病例；", "label": 11, "label_text": "Diagnostic", "id": "s4989"}
{"text": "a. 符合1995年全国第四届脑血管会议制定的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s4990"}
{"text": " 4、肿瘤不能RO切除，有肉眼血管或胆管癌栓，有肝外转移；", "label": 5, "label_text": "Multiple", "id": "s4991"}
{"text": " 16.其他研究者认为不合适入组的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s4992"}
{"text": " 14.试验给药前12周内接种过活性或减毒疫苗或免疫抑制剂者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s4993"}
{"text": " 4.患有严重的未控制的急性感染或主要脏器疾病者；", "label": 4, "label_text": "Disease", "id": "s4994"}
{"text": " 10.有器官移植史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s4995"}
{"text": "①确诊为急性白血病；", "label": 4, "label_text": "Disease", "id": "s4996"}
{"text": " 3.  Fitzpatrick类型I~V型，年龄3~75岁。", "label": 5, "label_text": "Multiple", "id": "s4997"}
{"text": " 3.了解本研究的目的，愿意参与并 签署患者知情同意书", "label": 13, "label_text": "Consent", "id": "s4998"}
{"text": "1.缺血性心脏病患者MI&lt;40天；", "label": 4, "label_text": "Disease", "id": "s4999"}
{"text": " ④自愿加入本实验，并签署“知情同意书”者。", "label": 13, "label_text": "Consent", "id": "s5000"}
{"text": " ③怀孕及哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5001"}
{"text": " 2）妊娠妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5002"}
{"text": " B.除原位宫颈癌、基底或鳞状细胞皮肤癌、（乳腺）导管内原位癌、器官局限性前列腺癌4种可行根治性切除的恶性肿瘤，5年内患有任何其他恶性肿瘤。", "label": 4, "label_text": "Disease", "id": "s5003"}
{"text": "1）18-70岁，性别不限，开口度正常；", "label": 5, "label_text": "Multiple", "id": "s5004"}
{"text": "（1）出生胎龄28周~35周的早产儿；", "label": 4, "label_text": "Disease", "id": "s5005"}
{"text": " - 近3周内未接受过其他药物治疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5006"}
{"text": " （3）ECOG评分:0-3；KPS≥50", "label": 9, "label_text": "Risk Assessment", "id": "s5007"}
{"text": " 10.心电图/心脏功能正常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5008"}
{"text": " （7）年龄在40和80岁之间（包括80岁）。", "label": 3, "label_text": "Age", "id": "s5009"}
{"text": " （5）婴幼儿。", "label": 3, "label_text": "Age", "id": "s5010"}
{"text": " （3）盐酸安罗替尼胶囊禁忌症患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5011"}
{"text": " ③年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s5012"}
{"text": " 3.  病理组织学明确的ER阳性和/或PR阳性患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5013"}
{"text": "1.符合抑郁症诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s5014"}
{"text": "1)试验前3个月每日吸烟量多于5支者或使用其他含有等量尼古丁的烟草制品。", "label": 36, "label_text": "Smoking Status", "id": "s5015"}
{"text": " （6）自愿参加本研究，并签署知情同意书，能随访。", "label": 5, "label_text": "Multiple", "id": "s5016"}
{"text": "1.男性和非妊娠哺乳期的女性门诊患者，年龄≥30且≤70岁，符合1998年WHO2型糖尿病诊断标准；", "label": 5, "label_text": "Multiple", "id": "s5017"}
{"text": " ? 不能口服药物；", "label": 17, "label_text": "Capacity", "id": "s5018"}
{"text": " 2.生命体征不稳定或不能完成完成颅脑核磁共振检查者。", "label": 5, "label_text": "Multiple", "id": "s5019"}
{"text": " 4）其他原因如药物、中毒、脑血管系统疾病引起的认知障碍者；", "label": 4, "label_text": "Disease", "id": "s5020"}
{"text": "1.经病理组织学或细胞学确诊的，且适合应用TAC/TA化疗方案的乳腺癌患者，或多西他赛/紫杉醇联合卡铂化疗方案的非小细胞肺癌患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5021"}
{"text": " （10）由于任何理由，研究者认为该受试者不适宜入组者。", "label": 21, "label_text": "Researcher Decision", "id": "s5022"}
{"text": " 11.洼田饮水试验≥4级及其他原因不能按时服药者；", "label": 5, "label_text": "Multiple", "id": "s5023"}
{"text": " 3)合并心肝肾和造血系统代谢性疾病（糖尿病、甲状腺疾病、肾上腺疾病），肿瘤者；", "label": 4, "label_text": "Disease", "id": "s5024"}
{"text": "1)血清铁蛋白&gt;1000 μg/L的地中海贫血症患者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5025"}
{"text": " i）患者生命体征稳定；", "label": 1, "label_text": "Sign", "id": "s5026"}
{"text": " 9.嗜烟者", "label": 2, "label_text": "Addictive Behavior", "id": "s5027"}
{"text": " 6.如为术后受试者，先前的抗癌药物治疗（化疗和/或靶向治疗）失败距入组本研究的时间须≥4周，且不良反应已基本恢复；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5028"}
{"text": " 5）纳入研究时生命体征不平稳的房颤发病患者；", "label": 4, "label_text": "Disease", "id": "s5029"}
{"text": " 5.持续性室速；", "label": 4, "label_text": "Disease", "id": "s5030"}
{"text": " （7）肝肾功能不全者；精神障碍者；酒精、药物滥用史；过敏体质；", "label": 5, "label_text": "Multiple", "id": "s5031"}
{"text": " 12)具有影响口服药物的多种因素（如无法吞咽和肠梗阻等）者；", "label": 5, "label_text": "Multiple", "id": "s5032"}
{"text": " 8.既往肾病综合征病史；", "label": 4, "label_text": "Disease", "id": "s5033"}
{"text": " 7.在首次疫苗接种前2周到末次接种后12个月，愿与性伴一起采取有效避孕措施。女性志愿者每次免疫接种前及随访时愿意接受尿妊娠检测。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5034"}
{"text": " 2）纽约心脏病协会心功能分级为II、III、IV级的心力衰竭。", "label": 5, "label_text": "Multiple", "id": "s5035"}
{"text": " 3)治疗前的经过多西他赛去势治疗但病情仍然进展；", "label": 5, "label_text": "Multiple", "id": "s5036"}
{"text": " 3.自愿参加并签知情同意书。", "label": 13, "label_text": "Consent", "id": "s5037"}
{"text": " 12、女方吸烟、酒精成瘾、吸毒等", "label": 5, "label_text": "Multiple", "id": "s5038"}
{"text": "① 年龄大于50岁或小于20岁，未经历性生活。", "label": 5, "label_text": "Multiple", "id": "s5039"}
{"text": " （2）其他病因（包括其他病毒感染、自身免疫性、药物性、酒精性、中毒性、Wilson病等代谢性疾病）导致的肝衰竭；", "label": 4, "label_text": "Disease", "id": "s5040"}
{"text": "1. 目前正在服用糖皮质激素类药物或免疫抑制剂者，如羟氯喹、环孢素、硫唑嘌呤等；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5041"}
{"text": " 4.取得患者或其法定代理人签署的知情同意书；", "label": 13, "label_text": "Consent", "id": "s5042"}
{"text": " 3）有严重消化系统疾病和严重营养不良者；", "label": 4, "label_text": "Disease", "id": "s5043"}
{"text": " 9.既往3个月内参加过其他临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5044"}
{"text": "1.HLA单倍体造血干细胞移植未发生急性移植物抗宿主病的患者；", "label": 5, "label_text": "Multiple", "id": "s5045"}
{"text": " (3)目标膝关节近3个月内关节腔注射糖皮质激素，或近2周内关节腔注射透明质酸钠，或近2周内接受针刺或艾灸治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5046"}
{"text": " 4.合并心、肺、脑、肾、肝等重要脏器的功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5047"}
{"text": " （2）有感染征象，血白细胞&gt;10.0×109", "label": 5, "label_text": "Multiple", "id": "s5048"}
{"text": " 8)ASA&gt;3级", "label": 9, "label_text": "Risk Assessment", "id": "s5049"}
{"text": " 4. 患者对任何已知或未知的磁共振对比剂成分过敏，或有严重过敏史的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s5050"}
{"text": "1 年龄≥65岁；", "label": 3, "label_text": "Age", "id": "s5051"}
{"text": " 2)住院时间少于7天或大于30天；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5052"}
{"text": "1）行气管切开机械通气患者；", "label": 38, "label_text": "Nursing", "id": "s5053"}
{"text": " 5.活动性溃疡及有出血倾向者。", "label": 5, "label_text": "Multiple", "id": "s5054"}
{"text": "1)试验前3个月每日吸烟量多于5支者；", "label": 36, "label_text": "Smoking Status", "id": "s5055"}
{"text": " （5）术前即患有明显的肺部疾病者；", "label": 4, "label_text": "Disease", "id": "s5056"}
{"text": " 6.近 2 个月内接受过外科手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5057"}
{"text": " 5.妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5058"}
{"text": " 5）妊娠及哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5059"}
{"text": " 2)知情同意", "label": 13, "label_text": "Consent", "id": "s5060"}
{"text": "1、有严重脏器功能障碍或疾病，如心、脑、肺、肾脏、胰腺等严重疾病及功能障碍。", "label": 5, "label_text": "Multiple", "id": "s5061"}
{"text": " ④术前1月内接受过腹部电子计算机断层扫描（CT）检查；", "label": 34, "label_text": "Device", "id": "s5062"}
{"text": " （3）年龄在7-14岁之间，患者能吸入ICS/LABA，并能够配合采集临床资料者；", "label": 5, "label_text": "Multiple", "id": "s5063"}
{"text": " （11）生命体征异常者（收缩压&lt;90mmHg或&gt;140mmHg，舒张压&lt;50mmHg或&gt;90mmHg；心率&lt;50bpm或&gt;100bpm）。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5064"}
{"text": "1.CAG上提示严重钙化和扭曲者；", "label": 11, "label_text": "Diagnostic", "id": "s5065"}
{"text": " 2,试验前1个月内有使用全身糖皮质激素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5066"}
{"text": " 4、受试者能遵守临床试验方案的要求，并且能完成2个月的研究随访。", "label": 8, "label_text": "Compliance with Protocol", "id": "s5067"}
{"text": " 5）出血量大，需要紧急诊刮止血者；", "label": 5, "label_text": "Multiple", "id": "s5068"}
{"text": "①6个月内有脑中风或心肌梗死者", "label": 4, "label_text": "Disease", "id": "s5069"}
{"text": "    b）候选人难以收集尿液，找不到助手;", "label": 17, "label_text": "Capacity", "id": "s5070"}
{"text": " 3、间质性肺炎", "label": 4, "label_text": "Disease", "id": "s5071"}
{"text": " 5. 妊娠或哺乳期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5072"}
{"text": " g)合并患有关节损伤疾病（如股骨头坏死等）的受试者。", "label": 4, "label_text": "Disease", "id": "s5073"}
{"text": " 11）目前存在不稳定或活动性溃疡或消化道出血的患者；", "label": 1, "label_text": "Sign", "id": "s5074"}
{"text": " （3）既往使用过盐酸文拉法新无效或不能耐受其副作用的患者；", "label": 5, "label_text": "Multiple", "id": "s5075"}
{"text": " 6）有严重的全身性疾病和活动期感染性疾病者。", "label": 4, "label_text": "Disease", "id": "s5076"}
{"text": " ④根据2型糖尿病防治指南需进行胰岛素强化治疗者：糖化血红蛋白HbA1C≥9.0%或空腹血糖≥11.1mmol/L。", "label": 5, "label_text": "Multiple", "id": "s5077"}
{"text": " (5)入组病例可以是初次诊断的患者，也可以是术后或放疗后复发、转移的患者，但复发、转移后未经治疗的患者；如果接受过辅助化疗，距辅助化疗结束至少需间隔半年以上；至少有一个可测量的肿瘤病灶，螺旋CT检查，其最大直径须≥10mm，普通或体格检查，其最大直径须≥10mm;", "label": 5, "label_text": "Multiple", "id": "s5078"}
{"text": " 4）在本研究开始前四周内曾参加其他临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s5079"}
{"text": " 3.在满足必需临床检验后，剩余的标本量不能满足二代测序要求。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5080"}
{"text": " 2)既往有精神病史或者家族精神病史", "label": 4, "label_text": "Disease", "id": "s5081"}
{"text": " 20.自签署同意书起至完成CART给药后6个月不愿意采取节育措施的女性受试者。", "label": 5, "label_text": "Multiple", "id": "s5082"}
{"text": " 腮腺区血管瘤", "label": 4, "label_text": "Disease", "id": "s5083"}
{"text": "1.年龄18~70岁男性或者女性；", "label": 5, "label_text": "Multiple", "id": "s5084"}
{"text": " （2）MMSE简易神经状态量表评分≥24分；", "label": 9, "label_text": "Risk Assessment", "id": "s5085"}
{"text": " (3) 标准干眼问卷（SPEED）评分≥6分；", "label": 9, "label_text": "Risk Assessment", "id": "s5086"}
{"text": " （13）药物成瘾或酒精成瘾患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s5087"}
{"text": " 2)依从性好，能配合试验观察，并签署书面的知情同意书；", "label": 5, "label_text": "Multiple", "id": "s5088"}
{"text": " （3）马尾神经综合征者；", "label": 4, "label_text": "Disease", "id": "s5089"}
{"text": " 3.病理证实大肠癌（包括高中分化管状腺癌、乳头状腺癌、低分化管状腺癌、黏液腺癌、印戒细胞癌）且CT示未有远处转移能进行根治性切除者[Dukes分期≤C2]", "label": 11, "label_text": "Diagnostic", "id": "s5090"}
{"text": " 2)对试验药品有过敏史，过敏体质（多种药物及食物过敏）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5091"}
{"text": " 3） 生命体征稳定；", "label": 1, "label_text": "Sign", "id": "s5092"}
{"text": " 3、肝病活动期或肝功异常，ALT、AST、TBIL为正常值上限1.5倍以上者", "label": 5, "label_text": "Multiple", "id": "s5093"}
{"text": " 6.至少接受4周治疗且有一次疗后数据；", "label": 5, "label_text": "Multiple", "id": "s5094"}
{"text": " 3.年龄0-14岁；", "label": 3, "label_text": "Age", "id": "s5095"}
{"text": " （2）哺乳期或怀孕妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5096"}
{"text": "1.以喘息为主要临床表现，肺部听诊有哮鸣音的患儿；", "label": 1, "label_text": "Sign", "id": "s5097"}
{"text": " (3) 物质滥用。", "label": 2, "label_text": "Addictive Behavior", "id": "s5098"}
{"text": " 4、精神障碍", "label": 4, "label_text": "Disease", "id": "s5099"}
{"text": " 1便血及肛门部肿物，可有肛门坠胀、异物感或疼痛。", "label": 28, "label_text": "Symptom", "id": "s5100"}
{"text": " 5)患者由于膝盖疼痛，至少在下列一项活动中有困难：举起和携带杂货，走路400米，进出椅子或上下楼梯；或具有机械特性的慢性膝关节疼痛；或由退行性软骨引起的关节肿胀，疼痛，僵硬，步态改变和运动丧失病史。", "label": 5, "label_text": "Multiple", "id": "s5101"}
{"text": "（1）存在可致口腔出现烧灼样疼痛的局部刺激因素者（包括不良修复体、尖锐牙尖、牙嵴、全口义齿等）；", "label": 30, "label_text": "Oral related", "id": "s5102"}
{"text": " 5)男性受试者体重不低于50 公斤、女性受试者体重不低于45公斤。体重指数（BMI）＝体重（kg）/身高2（m2），体重指数在18~28kg/m2范围内（包括临界值）；", "label": 5, "label_text": "Multiple", "id": "s5103"}
{"text": " ②频发晕厥，术前1年内发作&gt;3次和（或）近6月内有晕厥复发；", "label": 28, "label_text": "Symptom", "id": "s5104"}
{"text": " 3.年龄18-70岁，性别不限。", "label": 5, "label_text": "Multiple", "id": "s5105"}
{"text": " （4）自愿受试，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5106"}
{"text": " 5）对治疗药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s5107"}
{"text": " 3)患者依从性差；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5108"}
{"text": " 3）签署知情同意书", "label": 13, "label_text": "Consent", "id": "s5109"}
{"text": " ③近1月内发生过中-重度肝性脑病、食管胃底曲张静脉破裂出血或自发性细菌性腹膜炎等感染者；", "label": 4, "label_text": "Disease", "id": "s5110"}
{"text": " ③膝关节有明显疼痛或不适症状，且持续时间超过3个月；", "label": 4, "label_text": "Disease", "id": "s5111"}
{"text": " 14.有肺栓塞病史者；", "label": 4, "label_text": "Disease", "id": "s5112"}
{"text": "（1）符合NAFLD的西医诊断标准及中医辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s5113"}
{"text": " 2. BMI) &lt;18.5 kg/m2", "label": 9, "label_text": "Risk Assessment", "id": "s5114"}
{"text": " 3.运动波动和/或严重异动症患者", "label": 4, "label_text": "Disease", "id": "s5115"}
{"text": " J.四周内参加过其他药物临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5116"}
{"text": "（1）患有其他的严重威胁生命的疾病，如癌症晚期；", "label": 4, "label_text": "Disease", "id": "s5117"}
{"text": " 5.酒精或药物依赖.", "label": 2, "label_text": "Addictive Behavior", "id": "s5118"}
{"text": " 拟剖宫产终止妊娠；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5119"}
{"text": " （2）无能力完成调查问卷。", "label": 17, "label_text": "Capacity", "id": "s5120"}
{"text": " ⑨研究者认为不适宜参加试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s5121"}
{"text": " ⑸化疗方案需符合国内外主要临床实践指南或规范推荐的相应病种的标准化疗方案；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5122"}
{"text": " 3.选择年龄18~40岁或70~85岁择期下肢及会阴部手术", "label": 5, "label_text": "Multiple", "id": "s5123"}
{"text": " 3)年龄大于18岁且小于80岁", "label": 3, "label_text": "Age", "id": "s5124"}
{"text": " 4）筛选时生命体征（坐位血压、脉搏、体温、呼吸）、体格检查、实验室检查、心电图等检查结果正常或异常无临床意义，医生认为其健康状况良好；", "label": 5, "label_text": "Multiple", "id": "s5125"}
{"text": " ②合并先天性呼吸道、胸廓畸形的患者；", "label": 4, "label_text": "Disease", "id": "s5126"}
{"text": " 7孕妇或哺乳期妇女，以及有精神疾病或高敏感性的患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5127"}
{"text": " 3. 阿片类药物滥用成瘾或有吸毒病史患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s5128"}
{"text": " 2、患者或家属签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5129"}
{"text": " 9.酗酒及其他药物滥用史（酗酒标准：男性每日饮50克以上的酒精，女性每日饮30克以上的酒精；药物滥用通过临床症状判断）；", "label": 2, "label_text": "Addictive Behavior", "id": "s5130"}
{"text": " 2) 阵发性房颤患者", "label": 4, "label_text": "Disease", "id": "s5131"}
{"text": "1）有生育要求，符合计划生育相关法律规定有生育权利；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5132"}
{"text": "（1）患有神经系统疾病（如前庭病变、小脑病变、中枢性眩晕等）、心脑血管疾病（近6 个月有脑出血和脑栓塞的病史者）、眼部疾病及其他内科疾病可能引起平衡功能障碍导致老年人跌倒的受试者。", "label": 4, "label_text": "Disease", "id": "s5133"}
{"text": " （3）ECOG评分0～2分，预计生存期大于6个月；", "label": 5, "label_text": "Multiple", "id": "s5134"}
{"text": " （2）达到“尿毒症”诊断标准（血清肌酐大于707μmol/L或者GFR低于15ml/min），首次接受亲体同种异体肾移植；", "label": 5, "label_text": "Multiple", "id": "s5135"}
{"text": " 5、能够提供签署的书面知情同意书；", "label": 13, "label_text": "Consent", "id": "s5136"}
{"text": " 3、5≤SLE-DAI ≤14分，且当前糖皮质激素用量（以泼尼松计算）≤1mg/kg.d者", "label": 12, "label_text": "Laboratory Examinations", "id": "s5137"}
{"text": " 2.既往1个月以内接受过胸腔局部治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5138"}
{"text": " 2、受抗病毒，抗肿瘤或免疫抑制剂治疗者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5139"}
{"text": " 2)病理性骨折、严重骨质疏松性骨折；", "label": 4, "label_text": "Disease", "id": "s5140"}
{"text": " ③ASA分级1-3级。", "label": 9, "label_text": "Risk Assessment", "id": "s5141"}
{"text": "1、经胃镜和病理组织学检查符合胃癌前病变（轻度和中度异型增生）诊断的门诊及住院患者；", "label": 11, "label_text": "Diagnostic", "id": "s5142"}
{"text": " 4) 听神经瘤", "label": 4, "label_text": "Disease", "id": "s5143"}
{"text": " 4．经头颅CT或MRI检查证实", "label": 11, "label_text": "Diagnostic", "id": "s5144"}
{"text": " 7 伴有合并肿瘤。", "label": 4, "label_text": "Disease", "id": "s5145"}
{"text": " 10.育龄妇女必须已经采取可靠的避孕措施或在入组前7天内进行妊娠试验（血清或尿液），且结果为阴性，并且愿意在试验期间和末次给予试验药物后8周采用适当的方法避孕。对于男性，须同意在试验期间和末次给予试验药物后8周采用适当的方法避孕或已手术绝育；", "label": 5, "label_text": "Multiple", "id": "s5146"}
{"text": " 6）孕妇及哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5147"}
{"text": " 5)受试者有酒精滥用史，药物滥用史和/ 或阿片滥用史；", "label": 2, "label_text": "Addictive Behavior", "id": "s5148"}
{"text": "1. 按照Crowe分型，选取我科2011-2015年收治的Crowe III型DDH骨关节患者", "label": 5, "label_text": "Multiple", "id": "s5149"}
{"text": " 2). 确诊为恶病质的患者：近6个月体重下降超过5%或BMI&lt;20kg/m2且任意程度的体重下降超过2%或符合骨骼肌减少症诊断且任意程度的体重下降超过2%；", "label": 5, "label_text": "Multiple", "id": "s5150"}
{"text": " 5.因医学、精神、社会、职业等原因不能遵从研究方案或获得知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5151"}
{"text": " 酒精药物成瘾", "label": 2, "label_text": "Addictive Behavior", "id": "s5152"}
{"text": " （11）本人或者监护人能够并愿意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s5153"}
{"text": " （8）动脉期门静脉早期显影；", "label": 5, "label_text": "Multiple", "id": "s5154"}
{"text": " 5.   患者主要组织器官功能良好：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5155"}
{"text": " 6.合并恶性肿瘤或其他严重疾病患者;", "label": 4, "label_text": "Disease", "id": "s5156"}
{"text": " 4、合并严重肝功能衰竭及心血管、肺、肾和造血系统等严重原发性疾病，精神病患者；", "label": 4, "label_text": "Disease", "id": "s5157"}
{"text": " 2) 患者存在血小板减少或正接受抗凝治疗;", "label": 0, "label_text": "Therapy or Surgery", "id": "s5158"}
{"text": " 5.习惯性服用任何药物，包括中药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5159"}
{"text": " 4.手术或麻醉禁忌（严重心肺疾病不能耐受麻醉、凝血功能障碍等）；", "label": 5, "label_text": "Multiple", "id": "s5160"}
{"text": "1.妊娠或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5161"}
{"text": " ④无法定期来院随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5162"}
{"text": " 4 经由研究中心的心脏病专家确诊为心肌病（通过超声心动图测量的异常左心室质量指数[LVMIs]，对于年龄不超过12月龄的患儿，异常值定义为≥65 g/m2）。", "label": 5, "label_text": "Multiple", "id": "s5163"}
{"text": " ③移植前患病时间不限；", "label": 5, "label_text": "Multiple", "id": "s5164"}
{"text": " （3）合并有严重的血液病如白血病、再生障碍性贫血、骨髓增生异常综合征等。", "label": 4, "label_text": "Disease", "id": "s5165"}
{"text": " 9.有心、肝、肾、消化道、乳腺、生殖系统（卵巢、睾丸、附睾、子宫）等病史及神经精神系统病史者。", "label": 4, "label_text": "Disease", "id": "s5166"}
{"text": " 7. 预期寿命至少3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s5167"}
{"text": " （2）临床诊断2型糖尿病患者，年龄18-70岁", "label": 5, "label_text": "Multiple", "id": "s5168"}
{"text": " 6）能理解本试验并已签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5169"}
{"text": " 4.合并糖尿病、高血压等全身疾病。", "label": 4, "label_text": "Disease", "id": "s5170"}
{"text": " 2.拒绝参加本试验", "label": 13, "label_text": "Consent", "id": "s5171"}
{"text": " 4)玻璃体积血合并轻度视网膜纤维血管增生（早期的纤维血管膜、纤维血管膜较薄、和视网膜附着疏松，局部视网膜形态结构完整）", "label": 4, "label_text": "Disease", "id": "s5172"}
{"text": " 2.精神活性物质所致精神障碍。", "label": 4, "label_text": "Disease", "id": "s5173"}
{"text": " 7.试验开始前两周内使用过任何其他药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5174"}
{"text": "1.完成艾滋病疫苗（核酸与重组天坛痘苗联合使用）IIa期临床试验的健康受试者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5175"}
{"text": " 2.依據過度進食行為量表評估為過度進食。", "label": 9, "label_text": "Risk Assessment", "id": "s5176"}
{"text": " 6.入组前完善头颈部病变部位CT，淋巴结检查及内镜检查；", "label": 34, "label_text": "Device", "id": "s5177"}
{"text": "1.于我院就诊的30-45岁的DDH患者或者40-50岁的股骨颈骨折患者；", "label": 4, "label_text": "Disease", "id": "s5178"}
{"text": " 4.有脊柱畸形者；", "label": 4, "label_text": "Disease", "id": "s5179"}
{"text": " 2.术后病理组织学或者细胞学检查确诊的原发性肝细胞肝癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s5180"}
{"text": " 3、术前肢体存在感染，周围神经病变，肿瘤", "label": 4, "label_text": "Disease", "id": "s5181"}
{"text": " 4、预期寿命大于90天；", "label": 23, "label_text": "Life Expectancy", "id": "s5182"}
{"text": "1.性别：健康男性或女性；", "label": 5, "label_text": "Multiple", "id": "s5183"}
{"text": " （2）国籍为中国；", "label": 31, "label_text": "Ethnicity", "id": "s5184"}
{"text": " 4.三个月内参加其他相似的临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5185"}
{"text": "1、市区年龄8～15岁学龄儿童；", "label": 5, "label_text": "Multiple", "id": "s5186"}
{"text": " 2.有行无创机械通气的指征；预计无创机械通气治疗时间大于等于3天；", "label": 38, "label_text": "Nursing", "id": "s5187"}
{"text": " (3)研究治疗开始前1周和研究期间不能停用方案禁止的CYP同工酶抑制剂或诱导剂或具有抗肿瘤适应症的中药及中药制剂；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5188"}
{"text": " 4、慢性胰腺炎急性发作", "label": 4, "label_text": "Disease", "id": "s5189"}
{"text": " 2.治疗前至少有一处可测量病灶;", "label": 4, "label_text": "Disease", "id": "s5190"}
{"text": " （8）自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5191"}
{"text": " 病情稳定的患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s5192"}
{"text": " ③未经超声小探头探查的病例；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5193"}
{"text": " 9.口腔来源的口臭。", "label": 30, "label_text": "Oral related", "id": "s5194"}
{"text": " 3）筛选时HAMD-17总分≥14；", "label": 9, "label_text": "Risk Assessment", "id": "s5195"}
{"text": " 7、中度、严重的精神分裂症者", "label": 4, "label_text": "Disease", "id": "s5196"}
{"text": " f)有免疫缺陷病史，包括 HIV 阳性或患有其它获得性、先天性免疫缺陷疾病， 或有器官移植史者；", "label": 4, "label_text": "Disease", "id": "s5197"}
{"text": " （2）拟行体外受精-胚胎移植助孕者（长方案及拮抗剂方案）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5198"}
{"text": " 4. 自身免疫性疾病患者或其他免疫缺陷疾病者；", "label": 4, "label_text": "Disease", "id": "s5199"}
{"text": " 10.研究医生认为不适合参加该临床试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s5200"}
{"text": "患者在本研究开始用药前6个月接受过系统的抗病毒药物、免疫调节治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5201"}
{"text": "1.不符合空腹血糖异常合并高血压诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s5202"}
{"text": " 2、年龄：45岁以上。男女不限", "label": 5, "label_text": "Multiple", "id": "s5203"}
{"text": " 11)患有任何增加出血性风险的疾病，如痔疮、急性胃炎或胃及十二指肠溃疡等；", "label": 4, "label_text": "Disease", "id": "s5204"}
{"text": " 1.我院糖尿病住院患者", "label": 26, "label_text": "Encounter", "id": "s5205"}
{"text": " 4）外周血WBC计数&gt;12 000/mm3 或&lt;4000/mm3", "label": 12, "label_text": "Laboratory Examinations", "id": "s5206"}
{"text": "（1）合并有其他眼病（白内障、先天视网膜疾病、斜视、弱视等）和全身系统性疾病；", "label": 4, "label_text": "Disease", "id": "s5207"}
{"text": "①年龄18～70岁；", "label": 3, "label_text": "Age", "id": "s5208"}
{"text": "1年龄20～55周岁；", "label": 3, "label_text": "Age", "id": "s5209"}
{"text": " 6.曾接受分子靶向治疗者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5210"}
{"text": " 2）年龄&lt;6月，双心室修补，手术行主动脉重建", "label": 5, "label_text": "Multiple", "id": "s5211"}
{"text": " 患牙牙根完整，无肉眼可见根折线。", "label": 30, "label_text": "Oral related", "id": "s5212"}
{"text": " 6.过敏体质患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5213"}
{"text": " 2. 患儿易过敏或有蓝芩口服液过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5214"}
{"text": " 6.患者的角膜地形图形态正常", "label": 12, "label_text": "Laboratory Examinations", "id": "s5215"}
{"text": " 9.中性粒细胞减少症（中性粒细胞＜1*109/L）；", "label": 5, "label_text": "Multiple", "id": "s5216"}
{"text": " 14、研究者认为不适合参加本研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s5217"}
{"text": " 10. 肝功能不全（定义为ALT或总胆红素大于正常上限的3倍）；", "label": 5, "label_text": "Multiple", "id": "s5218"}
{"text": " 7.奶粉组：无法实施母乳喂养，决定采用婴儿配方奶粉喂养。其中无法实施母乳喂养的判定方法为：专业医生根据调查婴儿母亲在筛查调查表中的填写结果，及下述判定标准进行判定：1-15日龄婴儿配方奶粉喂养量≥250ml/d，开始喂养后奶粉喂养大于80%以上者。", "label": 5, "label_text": "Multiple", "id": "s5219"}
{"text": " 7、患者需满足以下血液学指标：中性粒细胞计数≥1.5×109/L;血红蛋白≥10.0g/dL;血小板计数≥100×109/L。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5220"}
{"text": "(1) 术前诊断肝脏肿瘤适合手术且涉及肝静脉根部 (至少一支主肝静脉受侵犯或受压)", "label": 11, "label_text": "Diagnostic", "id": "s5221"}
{"text": " 5）理解力及依从性良好，能够与研究者良好交流及遵照整个试验要求", "label": 8, "label_text": "Compliance with Protocol", "id": "s5222"}
{"text": " (7) 签署知情同意，依从性好。", "label": 5, "label_text": "Multiple", "id": "s5223"}
{"text": " ⑤受试者本人或法定监护人签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5224"}
{"text": "⑴ 0-1岁足月儿", "label": 3, "label_text": "Age", "id": "s5225"}
{"text": "1.符合西医失眠的诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s5226"}
{"text": " 4. 妊娠期。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5227"}
{"text": " （3）超声心动图显示(CMR二次证实)，CTD导致最大舒张末期右心室室壁厚&gt;4mm。", "label": 11, "label_text": "Diagnostic", "id": "s5228"}
{"text": "1.儿童口腔内开放性龋齿数目少于6;", "label": 30, "label_text": "Oral related", "id": "s5229"}
{"text": " 14) 怀孕及处于哺乳期者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5230"}
{"text": " (5)ALT异常，筛选时大于等于2倍正常值上限，但不超过正常值上限的10倍；并且入组前6个月内曾有ALT异常并且与筛选时的异常间隔超过一个月；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5231"}
{"text": " 17. 已参与其他药物或器械临床研究的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5232"}
{"text": " (7) 对干扰素或该制剂的任何成分有过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5233"}
{"text": " 4.口咽部手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5234"}
{"text": " 12.免疫缺陷或近3个月内服用免疫抑制剂或糖皮质激素患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5235"}
{"text": " 3）有微信且愿意接受干预信息推送；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5236"}
{"text": " 6.术前合并炎症反应（感染、活动性关节炎、恶性肿瘤）；", "label": 4, "label_text": "Disease", "id": "s5237"}
{"text": " ④妊娠或哺乳期女性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5238"}
{"text": " 4)HIV阳性", "label": 12, "label_text": "Laboratory Examinations", "id": "s5239"}
{"text": " 2. 感染性疾病（特别是结核、病毒性肝炎、HIV感染）；", "label": 4, "label_text": "Disease", "id": "s5240"}
{"text": "1.患者腰背部疼痛，且与核磁共振显示的椎体压缩性骨折部位一致；", "label": 5, "label_text": "Multiple", "id": "s5241"}
{"text": " （12）放疗涉及下颌骨。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5242"}
{"text": " 7）色盲、色弱、耳聋、口吃等影响神经认知测试者；", "label": 4, "label_text": "Disease", "id": "s5243"}
{"text": " 2.既往有腹部手术史。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5244"}
{"text": " 临床分期为ⅢB或Ⅳ期，预计生存期≥3个月；", "label": 5, "label_text": "Multiple", "id": "s5245"}
{"text": " （4）家长同意并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5246"}
{"text": " 3.年龄18～80岁；", "label": 3, "label_text": "Age", "id": "s5247"}
{"text": " 2)未出现过肠套叠或/和肠梗阻并发症（根据临床症状+影像学结果确定）。", "label": 4, "label_text": "Disease", "id": "s5248"}
{"text": " 7.研究者认为的其他不适合参与本研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s5249"}
{"text": " 17.首次给药前3个月内参加过其他临床试验者（筛查期问诊+联网筛查）；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5250"}
{"text": " 2. 根据精神疾病诊断和统计手册第4版（DSM-IV）诊断为MCI；", "label": 11, "label_text": "Diagnostic", "id": "s5251"}
{"text": " 2.血尿酸（sUA）&gt;480umol/l（8mg/dl）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5252"}
{"text": " 5.有精神病史、心理或智力障碍。", "label": 4, "label_text": "Disease", "id": "s5253"}
{"text": " 4.PCI术前或术后24内使用过肾毒性药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5254"}
{"text": "1.年龄在35岁至70岁之间的男性及非哺乳期或非孕期女性，患者依从性好；", "label": 5, "label_text": "Multiple", "id": "s5255"}
{"text": " 6.目前或近期（30天内）在进行其他药物研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5256"}
{"text": " 7.无法控制和/或诊断的内科情况，可能干扰或者影响研究治疗，如严重的肝、肾、心、脑疾病；未控制或未治疗的高血压（收缩压＞160mmHg和/或舒张压＞100mmHg）、未控制或未治疗的糖尿病；甲状腺功能亢进患者；", "label": 5, "label_text": "Multiple", "id": "s5257"}
{"text": " 3．已阅读了受试者须知，同意治疗并签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s5258"}
{"text": " 2、伤前有严重哮喘或慢性呼吸道疾病；", "label": 4, "label_text": "Disease", "id": "s5259"}
{"text": " 6 之前治疗的毒副作用已经恢复，洗脱期化疗大于4周，分子靶向药物大于2周。", "label": 5, "label_text": "Multiple", "id": "s5260"}
{"text": "1.ASA评分大于三级", "label": 9, "label_text": "Risk Assessment", "id": "s5261"}
{"text": " 11.过敏体质或对保妇康栓药物成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5262"}
{"text": " e)与食管运动功能异常相关的全身系统疾病（例如：硬皮病）", "label": 4, "label_text": "Disease", "id": "s5263"}
{"text": " 2) 妊娠和哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5264"}
{"text": " (4)意识不清，合并心血管、肝、肾、消化、造血系统等原发性疾病者，精神病患者。易合并感染及出血者。", "label": 4, "label_text": "Disease", "id": "s5265"}
{"text": " 5.两次体温超过37.5℃者。", "label": 1, "label_text": "Sign", "id": "s5266"}
{"text": " ②精神神经疾病；", "label": 4, "label_text": "Disease", "id": "s5267"}
{"text": " ④临床表现转移性右下腹或急性发作性右下腹疼痛；麦氏点压痛；或伴有肌紧张；", "label": 28, "label_text": "Symptom", "id": "s5268"}
{"text": " ⑦未签署知情同意书者；", "label": 13, "label_text": "Consent", "id": "s5269"}
{"text": "1)未签署书面的知情同意书或无法或不愿遵守研究者认可的研究方案。", "label": 5, "label_text": "Multiple", "id": "s5270"}
{"text": "①　合并慢性肾炎、尿毒症、甲状腺功能亢进、甲状旁腺功能亢进、慢性胃肠炎、肝病、糖尿病、类风湿关节炎及库欣综合征等可引起继发性骨质疏松症的疾病者；", "label": 4, "label_text": "Disease", "id": "s5271"}
{"text": "1、疾病急性期或慢性疾病急性发作期；", "label": 4, "label_text": "Disease", "id": "s5272"}
{"text": " 周围神经病变", "label": 4, "label_text": "Disease", "id": "s5273"}
{"text": " 15.受试者具有HIV、肝炎病毒、梅毒阳性；", "label": 4, "label_text": "Disease", "id": "s5274"}
{"text": " 2.皮损面积不超过其身体总体表面积(BSA)的10%，PASI评分≤10分;", "label": 9, "label_text": "Risk Assessment", "id": "s5275"}
{"text": " ⑥ 有食道超声心动图相关禁忌症的患者。", "label": 4, "label_text": "Disease", "id": "s5276"}
{"text": " J 血液病，或服用抗凝药物（肝素类，不包括阿司匹林），阿司匹林在疗程开始前7天停药，出院后可恢复", "label": 5, "label_text": "Multiple", "id": "s5277"}
{"text": " 3.流感重症或危重病例；", "label": 4, "label_text": "Disease", "id": "s5278"}
{"text": " 4)或有骨病及相关危险因素；", "label": 4, "label_text": "Disease", "id": "s5279"}
{"text": " 7.初中及以上文化水平；", "label": 41, "label_text": "Education", "id": "s5280"}
{"text": " 4）怀孕或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5281"}
{"text": " 7、有可能损害患者安全或研究数据完整性的任何状况，包括严重医学危险因素、医学状况、及实验室异常", "label": 22, "label_text": "Data Accessible", "id": "s5282"}
{"text": "1. 临床诊断胰体尾癌患者，年龄≥18岁，≤70岁，全身情况好，营养状态基本正常；未接受过术前化疗及术前放疗；无严重心、肺和肝肾功能障碍，无黄疸、腹水及消化道梗阻；血常规检查正常：WBC≥4，000/mm3；Hb≥100g/L；plt≥100，000/mm3；无急性感染。凝血机制正常，PT、KPTT、TT在正常范围；生活质量评分（Karnofsky 评分 ≥80 分）；手术耐受力好，能接受手术和放化疗者", "label": 5, "label_text": "Multiple", "id": "s5283"}
{"text": " （7）确定或可疑恶性高热病史或家族史；", "label": 4, "label_text": "Disease", "id": "s5284"}
{"text": "1) 年龄&gt;18岁", "label": 3, "label_text": "Age", "id": "s5285"}
{"text": " （3）合并COPD及其他肺部疾病者；", "label": 4, "label_text": "Disease", "id": "s5286"}
{"text": " 2.妊娠或准备妊娠妇女，哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5287"}
{"text": " 15.骨转移针对原发病灶的姑息性放疗者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5288"}
{"text": "1）第Ⅱ、Ⅲ、Ⅳ、Ⅴ类肺高压患者；", "label": 4, "label_text": "Disease", "id": "s5289"}
{"text": "（1）慢性神经、精神或躯体疾病；", "label": 4, "label_text": "Disease", "id": "s5290"}
{"text": " ③ 胃镜检查病理为非鳞癌；", "label": 11, "label_text": "Diagnostic", "id": "s5291"}
{"text": " 2)角膜溃疡；", "label": 4, "label_text": "Disease", "id": "s5292"}
{"text": " 10. 妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5293"}
{"text": " （4）发病后36小时内；", "label": 4, "label_text": "Disease", "id": "s5294"}
{"text": " 2)最近5年有其他恶性疾病史（治愈的皮肤癌和宫颈原位癌除外）；", "label": 4, "label_text": "Disease", "id": "s5295"}
{"text": " 8.正接受第二代TKI治疗的患者，获得分子学反应MR4.5（BCR-ABL1IS≤0.0032%，ABL1转录本 &gt; 32000）及更深的分子学反应至少1年，至少有2次RQ-PCR结果。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5296"}
{"text": " ?病人WHO体力状态评分&lt;2；", "label": 9, "label_text": "Risk Assessment", "id": "s5297"}
{"text": "① 青海地区行保胆取石手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5298"}
{"text": " 3)HBV DNA＞6 log10 copies/mL或200 000 IU/mL；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5299"}
{"text": " （3）曾经接受过大手术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5300"}
{"text": " 2) 患有白内障，并预期进行白内障超声乳化摘除术+人工晶状体植入术的患者，术眼核的硬度为1~3级；", "label": 5, "label_text": "Multiple", "id": "s5301"}
{"text": " （4）先天性脊柱裂等异常；", "label": 4, "label_text": "Disease", "id": "s5302"}
{"text": " 6．椎管内外肿瘤，椎管内较大蛛网膜囊肿，糖尿病性周围神经病变等；", "label": 4, "label_text": "Disease", "id": "s5303"}
{"text": " 7)   肝功能应达到Child-Pugh分级A或B，肾功能肌酐、尿素氮正常，WBC&gt;2X109/L、Hb&gt; 90g/L、PLT&gt;100X109/L。凝血酶原时间在正常范围内。", "label": 5, "label_text": "Multiple", "id": "s5304"}
{"text": " 3.ASA分级Ⅰ～Ⅲ级；", "label": 9, "label_text": "Risk Assessment", "id": "s5305"}
{"text": " （2）有活动性龋，或存在明显牙根暴露、牙龈萎缩情况", "label": 30, "label_text": "Oral related", "id": "s5306"}
{"text": " ⑦服用与治疗心律失常有关的中药2 周以内、西药5 个半衰期以内者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5307"}
{"text": " 3.妊娠期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5308"}
{"text": " 9.采样前1个月内无腹泻、痢疾等感染性胃肠道病史，", "label": 4, "label_text": "Disease", "id": "s5309"}
{"text": " 2. 根据EPOS诊断标准诊断为鼻息肉的患者；", "label": 11, "label_text": "Diagnostic", "id": "s5310"}
{"text": " （6）近三个月内参加过或正在参加其它临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5311"}
{"text": " 8. 骨髓增生不良或骨髓转移；", "label": 4, "label_text": "Disease", "id": "s5312"}
{"text": "   胸腔积液；双侧胸腔积液；恶性胸腔积液；渗出性胸腔积液；漏出性胸腔积液；结核性胸膜炎；肿瘤伴胸膜转移；多浆膜腔积液。", "label": 4, "label_text": "Disease", "id": "s5313"}
{"text": " (2)年龄1-7岁，性别不限;", "label": 5, "label_text": "Multiple", "id": "s5314"}
{"text": " ⑧因各种原因不能完成治疗方案，入组后三月内失随。", "label": 8, "label_text": "Compliance with Protocol", "id": "s5315"}
{"text": " 4. 年龄18～80周岁；", "label": 3, "label_text": "Age", "id": "s5316"}
{"text": "（1）术前进行放化疗患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5317"}
{"text": " 4 肝癌切除术后的预防性肝动脉化疗栓塞术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5318"}
{"text": "1)年龄18-75岁；", "label": 3, "label_text": "Age", "id": "s5319"}
{"text": "（1）多器官联合移植者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5320"}
{"text": " 3) 能够理解并自愿参加本次临床试验并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5321"}
{"text": " 8. 既往辅助治疗使用过研究药物；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5322"}
{"text": "1、怀孕妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5323"}
{"text": " 15，对研究中所使用的药物过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5324"}
{"text": " 8.不愿加入本试验者。", "label": 13, "label_text": "Consent", "id": "s5325"}
{"text": " 5、能够理解并提供书面的知情同意。", "label": 13, "label_text": "Consent", "id": "s5326"}
{"text": " (8)患有心脏功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5327"}
{"text": " 2）对示踪剂过敏的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s5328"}
{"text": " ④既往有肿瘤病史。", "label": 4, "label_text": "Disease", "id": "s5329"}
{"text": " 4、从事一般体力劳动，无职业性暴露于有害气体或粉尘工作史、无工作或居住环境物严重污染；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5330"}
{"text": " 2.对阿片类药物或右美托咪定过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5331"}
{"text": "原发性开角型青光眼患者：", "label": 4, "label_text": "Disease", "id": "s5332"}
{"text": " 3)直接侵犯胰腺的T4患者，或有胰腺切除史的患者；", "label": 5, "label_text": "Multiple", "id": "s5333"}
{"text": " 6.同侧腋窝淋巴结明显肿大互相融合或与其他组织粘连固定的；", "label": 5, "label_text": "Multiple", "id": "s5334"}
{"text": "1.年龄20-40岁，体重指数18-30 kg/m2；", "label": 5, "label_text": "Multiple", "id": "s5335"}
{"text": " （7）生殖器官畸形者；", "label": 4, "label_text": "Disease", "id": "s5336"}
{"text": "    （8）临床试验之前未接受过正规中医康复或现代康复治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s5337"}
{"text": "⑴ 早产儿", "label": 4, "label_text": "Disease", "id": "s5338"}
{"text": " 3.参试者需知情同意,志愿参加研究。", "label": 13, "label_text": "Consent", "id": "s5339"}
{"text": " （2）存在明显的其他异常体征、实验室检查和临床疾病，根据研究者的判", "label": 5, "label_text": "Multiple", "id": "s5340"}
{"text": "  b.II型呼吸衰竭：动脉血气分析PaCO2&gt;50mmHg。", "label": 5, "label_text": "Multiple", "id": "s5341"}
{"text": " 4)吸毒、药物依赖、酗酒、严重吸烟者。", "label": 2, "label_text": "Addictive Behavior", "id": "s5342"}
{"text": " 6.合并有严重心脏疾病（慢性心衰纽约分级标准心功能三级以上者、严重心律失常）、肝功能异常（AST、ALT≥正常值上限1.5倍）和造血系统（中度以上贫血）等严重疾病、精神病患者", "label": 5, "label_text": "Multiple", "id": "s5343"}
{"text": " 6) 签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5344"}
{"text": " 5.由疾病等原因导致的双上肢不能主动运动的患者；", "label": 17, "label_text": "Capacity", "id": "s5345"}
{"text": "① 合并HCV、HDV或HIV感染者；", "label": 4, "label_text": "Disease", "id": "s5346"}
{"text": " (9) 预测可能发生或曾发生困难气道者；", "label": 4, "label_text": "Disease", "id": "s5347"}
{"text": " 3）有IDA使用禁忌证，IDA总累计剂量达300mg/m2，或蒽环类药物使用超过剂量限制者；", "label": 5, "label_text": "Multiple", "id": "s5348"}
{"text": "1）存在心功能不全症状或体征；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5349"}
{"text": " 10、入组前90天发生颅内出血者（脑实质出血、蛛网膜下腔出血、硬膜下/外出血）；", "label": 1, "label_text": "Sign", "id": "s5350"}
{"text": "①符合普通感冒的西医诊断标准，中医证候诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s5351"}
{"text": " ?严重心肺肝肾等器官疾病", "label": 4, "label_text": "Disease", "id": "s5352"}
{"text": " ②患者罹患严重的进展性神经系统、心血管系统、呼吸系统或消化系统疾病；", "label": 4, "label_text": "Disease", "id": "s5353"}
{"text": " 11、严重感染，需要静脉使用抗生素、抗真菌或抗病毒治疗；", "label": 5, "label_text": "Multiple", "id": "s5354"}
{"text": "1、合并有严重心脑血管疾病或脏器衰竭不能耐受刺激者;", "label": 5, "label_text": "Multiple", "id": "s5355"}
{"text": " 6) 伦理委员会批准并且获得患者或其委托人签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s5356"}
{"text": "①受试者对器械材料及其降解产物(糠酸莫米松 左旋聚乳酸 消旋聚乳酸 乳酸丙交酯 乳酸)存在已知的过敏反应或禁忌症;", "label": 5, "label_text": "Multiple", "id": "s5357"}
{"text": " 11. 患有慢性肝病，且AST和直接胆红素≥2倍正常值", "label": 5, "label_text": "Multiple", "id": "s5358"}
{"text": " （12）病人和/或家属不愿意参加本试验，不愿意签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5359"}
{"text": "①急性心肌梗死，发病12h以内，", "label": 4, "label_text": "Disease", "id": "s5360"}
{"text": "1.长期服用阿片类药物或非甾体类镇痛药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5361"}
{"text": " 2. 内眼手术(除了单纯白内障手术)或玻璃体、视网膜、脉络膜或神经性疾病。", "label": 4, "label_text": "Disease", "id": "s5362"}
{"text": " 3）性别：不限；", "label": 35, "label_text": "Gender", "id": "s5363"}
{"text": "1. 对试验药物或紫杉醇有过敏反应；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5364"}
{"text": " ⑤心电图检查异常：窦性心动过缓或心脏传导阻滞；", "label": 4, "label_text": "Disease", "id": "s5365"}
{"text": " 3.过敏体质以及具有阿片类药物、曲马多过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5366"}
{"text": " （3）合并有严重原发性疾病患者和肿瘤患者，病情危重，难以对治疗的有效性和安全性做出确切评价者；", "label": 5, "label_text": "Multiple", "id": "s5367"}
{"text": " 3、妊娠期、哺乳期、绝经后；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5368"}
{"text": " ?肝、肾功能正常：AST≤60 U/L，血总胆红素≤1.5倍正常植上限，血清肌酐≤110umol/L，血清尿素氮7.1mmol/L；", "label": 5, "label_text": "Multiple", "id": "s5369"}
{"text": " （3）经全面健康体检合格，血常规、尿常规、血生化、血糖、血脂、HIV、HCV及心电图等检查正常，乙肝两对半表面抗原阴性、女性受试者尿妊娠试验阴性。", "label": 5, "label_text": "Multiple", "id": "s5370"}
{"text": " (6) 育龄女性须妊娠试验阴性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5371"}
{"text": " 备注：根据适合中国人的改良MDRD公式估算肾小球滤过率（eGFR）：eGFR(ml/min/1.73m2)=175×[血肌酐]-1.234×[年龄] -0.179×0.79(女性)。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5372"}
{"text": " 2.能够阅读、理解并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5373"}
{"text": "1.合并其它呼吸系统疾病：如支气管哮喘、支气管扩张症、活动性肺结核、肺间质纤维化、肺动脉高压、肺切除术后、肺癌等。", "label": 4, "label_text": "Disease", "id": "s5374"}
{"text": " ④病程小于6个月；", "label": 4, "label_text": "Disease", "id": "s5375"}
{"text": " （6）经术前放疗的患者状态良好可耐受外科手术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5376"}
{"text": "1) 同时接受多个器官移植的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5377"}
{"text": " 13. 研究者认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s5378"}
{"text": " （6）预期不能在指定临床实验中心随访者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5379"}
{"text": " 3、股腘动脉有单个和/或多个原发性闭塞、狭窄或再闭塞、再狭窄病变，造影显示狭窄程度≥70%，总长度≤15 cm；", "label": 5, "label_text": "Multiple", "id": "s5380"}
{"text": " 2. 急性闭角发作，由至少2种症状（如眼部疼痛和恶心/呕吐）、眼压超过21 mmHg、至少3种临床体征（例如角膜水肿、周边前房深度等于或小于四分之一角膜厚度、房角镜检查确认房角关闭等等）；", "label": 5, "label_text": "Multiple", "id": "s5381"}
{"text": " 16）研究者认为不适宜参加该临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s5382"}
{"text": "患者年龄在60岁—75岁之间，性别不限；", "label": 5, "label_text": "Multiple", "id": "s5383"}
{"text": " 6）最近3个月内参加过临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5384"}
{"text": " 3.既往无长期高原暴露史", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5385"}
{"text": " （5）本人或其监护人同意参加随机对照试验并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5386"}
{"text": "1.发病时间在48小时以内的颈内动脉系统缺血性脑卒中；", "label": 4, "label_text": "Disease", "id": "s5387"}
{"text": " 3、终末期肝病行肝移植术后患者", "label": 5, "label_text": "Multiple", "id": "s5388"}
{"text": " 5.心脏彩超证实为右向左分流的PFO", "label": 11, "label_text": "Diagnostic", "id": "s5389"}
{"text": " 3、轻度到中度肝硬化患者（Child-Pugh A和B）。", "label": 5, "label_text": "Multiple", "id": "s5390"}
{"text": " ⑷痞满症状不能排除心血管疾病（如心功能不全或心肌供血不足引起的痞满）、神经系统疾病（如神经性呕吐等）、胆道疾病（如胆囊结石）者", "label": 4, "label_text": "Disease", "id": "s5391"}
{"text": " 2) 不易配合患者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5392"}
{"text": " 5）患者同意纳入研究且愿意配合随访，包括采集婴儿信息及血样。", "label": 5, "label_text": "Multiple", "id": "s5393"}
{"text": " （4）存在不可切除的远处转移灶；", "label": 4, "label_text": "Disease", "id": "s5394"}
{"text": " 11)24h内应用华法林治疗且INR＞3；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5395"}
{"text": " （2）经麻醉评估认为不适宜纳入研究者；", "label": 21, "label_text": "Researcher Decision", "id": "s5396"}
{"text": " (2)体重指数为19.0~28.0kg/m2（含临界值），男性体重≥50kg，女性体重≥45kg；", "label": 5, "label_text": "Multiple", "id": "s5397"}
{"text": " 13) 合并GLP-1 激动剂治疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5398"}
{"text": " （2）2周内曾外用或口服激素、抗生素、维甲酸类等药物者；2周内接受光疗者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5399"}
{"text": "1.年龄40到75 岁之间；", "label": 3, "label_text": "Age", "id": "s5400"}
{"text": " 6）不能够手术切除或者患者拒绝手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5401"}
{"text": " 4.脑出血未破入脑室", "label": 4, "label_text": "Disease", "id": "s5402"}
{"text": "1、AECOPD住院患者，年龄≥40岁", "label": 5, "label_text": "Multiple", "id": "s5403"}
{"text": " 10. 已知有研究药物相关禁忌证（如对于思则凯过敏，糖皮质激素使用的禁忌症）。", "label": 5, "label_text": "Multiple", "id": "s5404"}
{"text": " 8.尿常规提示尿蛋白≥ ++，或证实24小时尿蛋白量≥1.0 g；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5405"}
{"text": " (3)同意并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5406"}
{"text": " 4.有精神分裂症病史；", "label": 4, "label_text": "Disease", "id": "s5407"}
{"text": " 10. 活动期的&gt;CTC AE 2级的临床严重感染；", "label": 5, "label_text": "Multiple", "id": "s5408"}
{"text": "1、以慢性腰痛或者慢性腰痛的急性发作期为主要观察对象，满足慢性腰痛的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s5409"}
{"text": "1) 初诊年龄12~20岁；", "label": 3, "label_text": "Age", "id": "s5410"}
{"text": " 3) 有药物（如阿巴卡韦或含有阿巴卡韦成分的药物）、食物或其他物质过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5411"}
{"text": " 16.患者术后剩余角膜基质厚度少于250um", "label": 12, "label_text": "Laboratory Examinations", "id": "s5412"}
{"text": " 6) 试验前3个月内服用了任何临床试验药物或参加了任何药物临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5413"}
{"text": " 4.第3天可移植胚胎数≥4个。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5414"}
{"text": " （9）研究者认为不应入组，如精神病，或其他重大疾病急性期者；", "label": 5, "label_text": "Multiple", "id": "s5415"}
{"text": "1.正在参加其它临床研究或在筛选访视前30天内正在接受任何其他研究治疗的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5416"}
{"text": " ③无明显的肝肾功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5417"}
{"text": " 6．血小板计数&lt; 100,000/mm3;", "label": 12, "label_text": "Laboratory Examinations", "id": "s5418"}
{"text": " ⑵长期使用激素史者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5419"}
{"text": " 2. 年龄&gt;18岁至﹤80岁的患者;", "label": 3, "label_text": "Age", "id": "s5420"}
{"text": " 伴有严重心、肝、肾功能不全的患者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5421"}
{"text": " （14）中文不流利；", "label": 25, "label_text": "Literacy", "id": "s5422"}
{"text": " 8.过敏体质，以及对两种或以上药物或食物过敏；或已知对本药成分过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5423"}
{"text": " a.放置宫内避孕器 (IUD) 或宫内避孕系统 (IUS)。", "label": 34, "label_text": "Device", "id": "s5424"}
{"text": " (18) 由研究者判断不适合入选试验的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s5425"}
{"text": " 9.育龄妇女必须在入组前7天进行妊娠试验（血清或尿液），且结果为阴性，并且愿意在试验期间和末次给药后8周采用适当的方法避孕。对于男性，应用手术绝育，或同意在试验期间或末次给药后8周采用适当的方法避孕。", "label": 5, "label_text": "Multiple", "id": "s5426"}
{"text": " 17)不管严重程度如何，存在任何出血体质迹象或病史的患者；在分组前4周内，出现任何出血或流血事件≥CTCAE 3级的患者，存在未愈合创口、溃疡或骨折；", "label": 5, "label_text": "Multiple", "id": "s5427"}
{"text": " (7)有严重的神经系统疾病史；", "label": 4, "label_text": "Disease", "id": "s5428"}
{"text": " （7）病理性骨折。", "label": 4, "label_text": "Disease", "id": "s5429"}
{"text": " 4.人工膝关节翻修者", "label": 0, "label_text": "Therapy or Surgery", "id": "s5430"}
{"text": "年龄&gt;18岁", "label": 3, "label_text": "Age", "id": "s5431"}
{"text": " h)皮肤痤疮、红肿等；", "label": 4, "label_text": "Disease", "id": "s5432"}
{"text": "1.符合上述不同类型脑瘫诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s5433"}
{"text": " （2）高血压、糖尿病、冠心病患者；", "label": 4, "label_text": "Disease", "id": "s5434"}
{"text": " （3）肿瘤未侵犯腔静脉或肝门一级分支。", "label": 24, "label_text": "Neoplasm Status", "id": "s5435"}
{"text": " 4.筛选期用美普清诊断性治疗3天后，咳嗽症状有缓解。", "label": 5, "label_text": "Multiple", "id": "s5436"}
{"text": " （2）近期有急性感染史或感染症状；", "label": 5, "label_text": "Multiple", "id": "s5437"}
{"text": "1.孕妇或哺乳期患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5438"}
{"text": " 18) 在服用研究药物前48 小时摄取了巧克力、任何含咖啡因或富含黄嘌呤食物或饮料；", "label": 18, "label_text": "Diet", "id": "s5439"}
{"text": " (3) 符合中医证候诊断标准的患者。", "label": 11, "label_text": "Diagnostic", "id": "s5440"}
{"text": " （7）QT/QTc间期延长者（QTc间期＞450ms），或者伴有可导致尖端扭转（TdP）疾病史者，如心衰、低血钾及家族性长QT综合征者，或合并使用可至QT/QTc间期延长的药物；", "label": 5, "label_text": "Multiple", "id": "s5441"}
{"text": " (3)美国麻醉师协会（American Society of Anesthesiologists，ASA）分级为Ⅰ－Ⅱ级；", "label": 9, "label_text": "Risk Assessment", "id": "s5442"}
{"text": "1.来创伤三科就诊的膝关节骨折合并软组织损伤的患者", "label": 4, "label_text": "Disease", "id": "s5443"}
{"text": " 11)有吞咽困难或任何影响药物吸收的胃肠道疾病史。", "label": 4, "label_text": "Disease", "id": "s5444"}
{"text": " 5)目标眼存在影响BCVA的其他眼病、疾病或正口服影响BCVA的药物（除外轻度屈光介质混浊，如：未在瞳孔区的角膜云翳；分级≤C2N1P0的白内障）；", "label": 5, "label_text": "Multiple", "id": "s5445"}
{"text": " (3) 中性粒细胞&lt;1.0×109/L，血小板&lt;50×109/L，血红蛋白&lt;80g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5446"}
{"text": " 3. 患者不同意进行本研究或入组后三个月内失访；", "label": 5, "label_text": "Multiple", "id": "s5447"}
{"text": " 3、HSCT后 4.5个月 时仍处于CR状态", "label": 0, "label_text": "Therapy or Surgery", "id": "s5448"}
{"text": " ⑦不签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5449"}
{"text": " 4. 合并全身疾病、肝肾功能严重障碍的患者；", "label": 5, "label_text": "Multiple", "id": "s5450"}
{"text": " （4）恶性肿瘤或其他可能影响正确评估疗效的严重疾病者；", "label": 4, "label_text": "Disease", "id": "s5451"}
{"text": " 3、严重糖尿病急性并发症", "label": 4, "label_text": "Disease", "id": "s5452"}
{"text": " ⑤已明确其他类型的生长发育异常，如Turner综合征、体质性青春期发育延迟、Laron综合征、生长激素受体缺乏等，生长落后的女孩未排除染色体异常者；", "label": 4, "label_text": "Disease", "id": "s5453"}
{"text": " (4) 日常工作强度过大或者强度无法控制", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5454"}
{"text": " ②严重肝、肾功能不全（GFR＜30ml/1.73m2和ALT正常值上限2.5倍者）； 出凝血障碍性疾病、曾有消化性溃疡、脑出血病史、血小板计数异常（PLT＞300×109/L或＜100×109/L）；", "label": 5, "label_text": "Multiple", "id": "s5455"}
{"text": " 6) 拒绝在指导下调整饮食和运动习惯；", "label": 13, "label_text": "Consent", "id": "s5456"}
{"text": " 其他研究者认为不适宜入选的情况（需注明具体原因）。", "label": 21, "label_text": "Researcher Decision", "id": "s5457"}
{"text": " ⑩有严重的其它系统疾病需要治疗者；", "label": 4, "label_text": "Disease", "id": "s5458"}
{"text": "1.妊娠或有妊娠需求的女性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5459"}
{"text": "1.明确诊断为恶性血液病患者，体重不限，年龄不限，性别不限，种族不限；", "label": 5, "label_text": "Multiple", "id": "s5460"}
{"text": " （6）患者对临床研究方案充分了解，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5461"}
{"text": " 6.未行术前新辅助化疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s5462"}
{"text": " 5. 术前ODI≥30", "label": 9, "label_text": "Risk Assessment", "id": "s5463"}
{"text": " 4.自愿参加且填写同意书", "label": 13, "label_text": "Consent", "id": "s5464"}
{"text": " 2.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5465"}
{"text": " 3. 选择胶连全口义齿进行修复的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5466"}
{"text": " 5、诊断不明确的脊柱损伤伴脊髓损伤症状者；", "label": 4, "label_text": "Disease", "id": "s5467"}
{"text": " 2.18-45岁的育龄女性", "label": 5, "label_text": "Multiple", "id": "s5468"}
{"text": " 2）蒙特利尔认知评估量表（MoCA）得分&lt;26,若受教育年限≤12 年则在得分基础上加 1 分", "label": 5, "label_text": "Multiple", "id": "s5469"}
{"text": " 10.血甘油三酯&gt; 500 mg/dL 或&gt; 5.7 mmol/L 的受试者（依据CTCAE5.0 版）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5470"}
{"text": " 8.近六个月内出现过：心肌梗死，心脏手术，不稳定性心绞痛充血性心力衰竭，暂行性脑缺血或显著脑血管疾病等；", "label": 5, "label_text": "Multiple", "id": "s5471"}
{"text": " （7）3个月内用过已知对某脏器有损害的药物，近2周内曾服用过各种药物，4周内曾应用研究用药者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5472"}
{"text": " 2.符合《原发性肝癌诊疗规范》（2011版）临床诊断标准或经病理组织学或细胞学检查确诊的原发性肝癌，且至少有一个可测量病灶（RECIST 1.1）；", "label": 11, "label_text": "Diagnostic", "id": "s5473"}
{"text": " 4、精神病患者；", "label": 4, "label_text": "Disease", "id": "s5474"}
{"text": "1)怀孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5475"}
{"text": " ③患严重高血压及心血管疾病", "label": 4, "label_text": "Disease", "id": "s5476"}
{"text": " (11)因整形美容、矫正、治疗或外伤等原因进行蝶腭骨神经节区面部手术者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5477"}
{"text": " 6、正参加其他临床研究的病例", "label": 15, "label_text": "Enrollment in other studies", "id": "s5478"}
{"text": " 2.认知功能障碍、痴呆患者；", "label": 4, "label_text": "Disease", "id": "s5479"}
{"text": " 10）长期酗酒者（最近三月未戒酒）；", "label": 2, "label_text": "Addictive Behavior", "id": "s5480"}
{"text": " 4）相关过敏史/超敏反应史（包括对亚硝脲类烷化剂药物或其赋形剂过敏）", "label": 7, "label_text": "Allergy Intolerance", "id": "s5481"}
{"text": " 5.严重骨关节疾病不能行截石位患者；", "label": 4, "label_text": "Disease", "id": "s5482"}
{"text": " 9.受试者自愿参加本次临床试验，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5483"}
{"text": " （3）检查 X线检查正常", "label": 12, "label_text": "Laboratory Examinations", "id": "s5484"}
{"text": " 5、近期有活动性感染者。", "label": 4, "label_text": "Disease", "id": "s5485"}
{"text": " 有精神疾病等，预期依从性不良的患者", "label": 5, "label_text": "Multiple", "id": "s5486"}
{"text": " （4）年龄18～65岁；性别不限。", "label": 5, "label_text": "Multiple", "id": "s5487"}
{"text": " 2 肾功能Scr&gt;1.5mg/dL", "label": 12, "label_text": "Laboratory Examinations", "id": "s5488"}
{"text": " 16) 需行眼部联合手术者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5489"}
{"text": " 11)每天饮用过量茶、咖啡或含咖啡因的饮料（8杯以上，每杯200mL）者；（问诊）", "label": 18, "label_text": "Diet", "id": "s5490"}
{"text": " （6）艾滋病毒、梅毒血清学反应为阳性、没有得到控制的乙肝病毒或丙肝病毒感染者；", "label": 5, "label_text": "Multiple", "id": "s5491"}
{"text": " ③ 器质性疾病患者（尤其是存在下丘脑－垂体－肾上腺轴疾病的患者）；", "label": 4, "label_text": "Disease", "id": "s5492"}
{"text": " 5.自愿参加并已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5493"}
{"text": " 5）接受HIPEC前肝功能无异常（总胆红素3.4-22.2μmol/L，ALT 7-40 U/L， AST 13-35U/L，AST/ALT≤1.5）；", "label": 5, "label_text": "Multiple", "id": "s5494"}
{"text": " 4.假体位置不良及术后假体周围感染的患者；", "label": 4, "label_text": "Disease", "id": "s5495"}
{"text": "（1）严重心脏传导阻滞的患者；", "label": 4, "label_text": "Disease", "id": "s5496"}
{"text": " (2)年龄≥20周岁,＜80周岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s5497"}
{"text": " 7.国际勃起功能评分IIEF-5在5-21分之间；", "label": 9, "label_text": "Risk Assessment", "id": "s5498"}
{"text": " （6）愿意签署知情同意书，能理解、接受康复指导并实施。", "label": 5, "label_text": "Multiple", "id": "s5499"}
{"text": " (7) 已知或疑似依从性差不能完成试验者， 如酗酒、药物依赖或精神疾病等;", "label": 5, "label_text": "Multiple", "id": "s5500"}
{"text": " 10.筛选前14天内摄入大量富含葡萄柚（西柚）的饮料或食物者（如葡萄柚、葡萄柚汁、葡萄柚果酱等），或不同意试验期间停止食用上述食物者（筛查期问诊）；", "label": 18, "label_text": "Diet", "id": "s5501"}
{"text": " ②伴有胃肠道相关器质性病变的患者", "label": 4, "label_text": "Disease", "id": "s5502"}
{"text": " （2）移植术前发现多源发癌或肝癌有肝外转移灶者", "label": 5, "label_text": "Multiple", "id": "s5503"}
{"text": " 7.哺乳期、妊娠期或正准备妊娠的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5504"}
{"text": " 4.研究开始前4周内参加过其他药物临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5505"}
{"text": " (8)有精神性疾病无法合作的受试者；", "label": 4, "label_text": "Disease", "id": "s5506"}
{"text": " 3）气管插管或气管切开患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5507"}
{"text": " ⑤近2周内未使用任何外用药物治疗本病的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5508"}
{"text": " 2．子宫内膜异位症III级以上患者", "label": 4, "label_text": "Disease", "id": "s5509"}
{"text": " 2，对本品中任何成分过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s5510"}
{"text": " 5、出现以下任何一项并发症：胃肠道出血或梗阻；活动性心脏病（包括不稳定性心绞痛，心肌梗塞，心衰）；间质性肺炎或肺纤维化；未控的糖尿病；未控的腹泻；未控的高血压；", "label": 4, "label_text": "Disease", "id": "s5511"}
{"text": " 6.术后病理基因检测提示有效监测点并使用靶向药", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5512"}
{"text": " ②严重心肺功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5513"}
{"text": " 8、妊娠、哺乳或有妊娠计划及可能的患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5514"}
{"text": " 14. 酒精滥用 （多于 60 g/天）；", "label": 2, "label_text": "Addictive Behavior", "id": "s5515"}
{"text": " 3)既往有乙肝、丙肝、HIV感染、梅毒等传染性疾病史者；", "label": 4, "label_text": "Disease", "id": "s5516"}
{"text": " b)WBC≥1.5×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5517"}
{"text": "（1）总胆固醇：&gt;6.22mmol/L 甘油三酯&gt;2.26 mmol/L,或者根据《中国成年人血脂异常防治指南》需要入院治疗的患者。", "label": 5, "label_text": "Multiple", "id": "s5518"}
{"text": " 12. 未绝育的男性须在研究期间、及最后一次信迪利单抗给药和最后一次化疗后，均要求至少180天采取高效避孕。建议在研究治疗首次给药前至少3个月开始采取避孕措施。", "label": 5, "label_text": "Multiple", "id": "s5519"}
{"text": " 4.拒绝接受相关治疗方案或随访方案；", "label": 5, "label_text": "Multiple", "id": "s5520"}
{"text": "1、年龄18-80 岁；", "label": 3, "label_text": "Age", "id": "s5521"}
{"text": " 6)已知情同意并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5522"}
{"text": " ⑧自愿加入本试验并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5523"}
{"text": " 8.近期有胃肠道手术，", "label": 0, "label_text": "Therapy or Surgery", "id": "s5524"}
{"text": " ⑥过敏体质或对多种药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s5525"}
{"text": " 4.能理解随访问卷的调查；", "label": 17, "label_text": "Capacity", "id": "s5526"}
{"text": " （3）签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5527"}
{"text": "①确诊CD患者（临床诊断和/或病理诊断）", "label": 11, "label_text": "Diagnostic", "id": "s5528"}
{"text": "1.之前接受过针对骨髓瘤的治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5529"}
{"text": "1. 性别：男性或女性，研究开始前签署知情同意书/患者回访卡", "label": 5, "label_text": "Multiple", "id": "s5530"}
{"text": " 5.意识不能配合的患者；", "label": 17, "label_text": "Capacity", "id": "s5531"}
{"text": " 7.生存预期≥3个月。", "label": 23, "label_text": "Life Expectancy", "id": "s5532"}
{"text": " 6）有反流误吸可能患者。", "label": 28, "label_text": "Symptom", "id": "s5533"}
{"text": " ⑵  吞咽障碍。", "label": 4, "label_text": "Disease", "id": "s5534"}
{"text": " 10、明显病态体质（其他急慢性疼痛、感染、恶性肿瘤、预期寿命较短、心血管疾病、脑血管疾病、未控制的高血压、退行性中枢神经系统疾病等）的患者。", "label": 5, "label_text": "Multiple", "id": "s5535"}
{"text": " （3）初诊为高血压或虽经高血压治疗，血压仍未达标；", "label": 5, "label_text": "Multiple", "id": "s5536"}
{"text": " 15、活动性肺结核、乙肝急性期、丙肝急性期、HIV感染的患者", "label": 4, "label_text": "Disease", "id": "s5537"}
{"text": " 10.重要器官耐受良好;", "label": 7, "label_text": "Allergy Intolerance", "id": "s5538"}
{"text": " (2)合并严重系统疾病，如心血管系统疾病，糖尿病，肾病及消化系统疾病；", "label": 4, "label_text": "Disease", "id": "s5539"}
{"text": " 7) 3个月内参加过其它临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5540"}
{"text": " (3)拒绝或害怕针刺干预；", "label": 13, "label_text": "Consent", "id": "s5541"}
{"text": "1.患者拒绝参加该研究", "label": 13, "label_text": "Consent", "id": "s5542"}
{"text": " 有活动性的病毒或细菌感染，且未能用适当的抗感染治疗进行控制；", "label": 5, "label_text": "Multiple", "id": "s5543"}
{"text": "1）TACE标准必须和原发性肝癌诊疗规范(2011年版)一致，严格把握适应症属于禁忌症的必须排除。", "label": 11, "label_text": "Diagnostic", "id": "s5544"}
{"text": " 3.胃大部切除患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s5545"}
{"text": " 3.临床认为明显自杀倾向；", "label": 11, "label_text": "Diagnostic", "id": "s5546"}
{"text": " （3）有严重心、肝、肾、脑、血液系统等并发症或合并其它严重原发性疾病、精神病患者；", "label": 4, "label_text": "Disease", "id": "s5547"}
{"text": "1.符合慢性湿疹的临床诊断；", "label": 11, "label_text": "Diagnostic", "id": "s5548"}
{"text": " —既往5年内出现过其它恶性肿瘤，但经过适当治疗的宫颈原位癌或非黑色素瘤皮肤癌除外", "label": 4, "label_text": "Disease", "id": "s5549"}
{"text": " （4）神志不清、痴呆、各种精神病患者；", "label": 4, "label_text": "Disease", "id": "s5550"}
{"text": " 5、在入选研究前的3 个月内服用其他试验药或参与了其他临床试验", "label": 15, "label_text": "Enrollment in other studies", "id": "s5551"}
{"text": " 8. 3个月内参加过其他临床研究的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s5552"}
{"text": " （7）孕期或哺乳期妇女及计划在研究期内怀孕的妇女等；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5553"}
{"text": " 3、妊娠期或哺乳期的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5554"}
{"text": " 6)受试者志愿受试并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5555"}
{"text": " 8、合并造血系统疾病、恶性肿瘤、自身免疫性疾病和传染病（肺结核、病毒性肝炎、梅毒、艾滋病）的患者；", "label": 4, "label_text": "Disease", "id": "s5556"}
{"text": " ⑤ 无合并全身其他系统重大基础病可能影响各种指标及预后者；", "label": 4, "label_text": "Disease", "id": "s5557"}
{"text": "(1)在任何研究相关程序开始前获得患者签署的知情同意书。患者对本研究已充分了解并自愿签署书面知情同意书；", "label": 13, "label_text": "Consent", "id": "s5558"}
{"text": " （2）经彩超、X线或CT检查证实，患有≤2cm的输尿管上段结石或肾结石，或单侧肾多发结石且最大径相加≤2cm；", "label": 11, "label_text": "Diagnostic", "id": "s5559"}
{"text": " 7.在本试验开始前30天内参加了其他临床试验的志愿者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5560"}
{"text": "1.18-70岁的成年男性或女性;", "label": 5, "label_text": "Multiple", "id": "s5561"}
{"text": " 6. 基准检查前30天内参与涉及到治疗药物或医疗器材其他眼科临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s5562"}
{"text": " （5）1年内未服用过核苷类抗病毒药物，6个月内未进行过肝纤维化药物治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5563"}
{"text": " （2）妊娠或哺乳期妇女，研究期间有生育计划的患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5564"}
{"text": " ③ ECOG评分≥2分；", "label": 9, "label_text": "Risk Assessment", "id": "s5565"}
{"text": " 4)年龄为18～65岁男性和女性受试者（包括18岁和65岁）；", "label": 5, "label_text": "Multiple", "id": "s5566"}
{"text": " 10) 月经期、妊娠期和哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5567"}
{"text": "1.年龄在20至40岁之间的已婚女性；", "label": 5, "label_text": "Multiple", "id": "s5568"}
{"text": " 3）严重心衰或呼吸衰竭；严重颅脑外伤伴颅底骨折；脑昏迷；急性上呼吸道感染；", "label": 4, "label_text": "Disease", "id": "s5569"}
{"text": " （4）符合术后肺部并发症高危患者标准（Canet评分&gt;=45分）。", "label": 9, "label_text": "Risk Assessment", "id": "s5570"}
{"text": "1、任何不利于胚胎着床的负面因素，如：宫腔粘连，严重的输卵管积水，Ⅲ到Ⅳ期的子宫内膜异位症，接近宫腔的子宫肌瘤或者子宫腺肌瘤，无反应性薄型子宫内膜", "label": 5, "label_text": "Multiple", "id": "s5571"}
{"text": " 4.头颅MRI检查确诊为急性脑梗死；", "label": 11, "label_text": "Diagnostic", "id": "s5572"}
{"text": " 5. 距离月经初潮1年以内的女性患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5573"}
{"text": "①疼痛与肿瘤本身及其诊断、治疗无关者；", "label": 5, "label_text": "Multiple", "id": "s5574"}
{"text": " （5）无可能引发上肢水肿的非乳腺手术或治疗史，如：胸部手术、腋部手术、肩部手术、上肢手术以及上述部位放射治疗史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5575"}
{"text": " 4.均质性病变和/或下叶病变严重者(组织空气比&lt;11%)；", "label": 4, "label_text": "Disease", "id": "s5576"}
{"text": " 3) 心肾肺等器官功能不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5577"}
{"text": " 5. 受试者基线血常规和生化指标符合下列标准：", "label": 12, "label_text": "Laboratory Examinations", "id": "s5578"}
{"text": " 11. 对于既往使用过化疗的受试者，根据NCI-CTCAE 4.0标准，入组时存在≥2级血液学毒性，或≥3级非血液学毒性；", "label": 5, "label_text": "Multiple", "id": "s5579"}
{"text": " 3.严重的肝肾功能障碍，严重的心肺功能障碍。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5580"}
{"text": " 6) 有中度以上心脏瓣膜疾病的患者", "label": 4, "label_text": "Disease", "id": "s5581"}
{"text": " 11. 脑脊液检查白血病细胞&gt;20个/ul；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5582"}
{"text": " [3]身体状况能够耐受手术治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5583"}
{"text": " （1）年龄小于25周岁或大于80周岁；不符合结节性甲状腺肿手术指征的患者；", "label": 5, "label_text": "Multiple", "id": "s5584"}
{"text": " F.使用胆碱酯酶抑制剂、美金刚、奥拉西坦等药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5585"}
{"text": "（1）年龄18-75岁；", "label": 3, "label_text": "Age", "id": "s5586"}
{"text": " ⑦有严重的心、肝、肾功能不全，严重的神经病变或精神疾病患者；", "label": 4, "label_text": "Disease", "id": "s5587"}
{"text": " 2.男女不限，年龄20岁～65岁", "label": 5, "label_text": "Multiple", "id": "s5588"}
{"text": " 4)中风次数≤2次者，本次中风发病2周-6个月。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5589"}
{"text": " 16，计划在试验期间献血的病人。", "label": 14, "label_text": "Blood Donation", "id": "s5590"}
{"text": " ⑤ 自愿签署知情同意。", "label": 13, "label_text": "Consent", "id": "s5591"}
{"text": "1）对钛合金内植物过敏的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s5592"}
{"text": "1.年龄大于或等于18周岁入住重症病房患者，性别不限。", "label": 5, "label_text": "Multiple", "id": "s5593"}
{"text": " 2合并严重发育性椎管狭窄或其他严重畸形者。", "label": 4, "label_text": "Disease", "id": "s5594"}
{"text": "①年龄≥18岁成年患者；", "label": 3, "label_text": "Age", "id": "s5595"}
{"text": " (6) 本次偏头痛发作部位为 “左侧”手足少阳经循行区域；", "label": 28, "label_text": "Symptom", "id": "s5596"}
{"text": " b. 终末期肾病；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s5597"}
{"text": " (5)由于智力或行为障碍不能充分配合试验和调查者。", "label": 5, "label_text": "Multiple", "id": "s5598"}
{"text": " 5门静脉血栓形成。", "label": 4, "label_text": "Disease", "id": "s5599"}
{"text": " 4.入组当天尿检阿片类定性测试为阴性的。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5600"}
{"text": " 4. 患有高血压，且经降压药物治疗无法获得良好控制者（收缩压&gt;150 mmHg，舒张压&gt;100 mmHg）；患有Ⅱ级以上心肌缺血或心肌梗塞、控制不良的心律失常（包括QTC间期≥450 ms）及按照NYHA标准Ⅲ～Ⅳ级心功能不全；心脏彩超检查：LVEF（左室射血分数）＜50%；", "label": 5, "label_text": "Multiple", "id": "s5601"}
{"text": " 3. 以阿片类药物滥用为主。", "label": 2, "label_text": "Addictive Behavior", "id": "s5602"}
{"text": "1.年龄18-70岁，于2017年03月到2017年06月来我院内分泌科门诊就诊的患者；", "label": 5, "label_text": "Multiple", "id": "s5603"}
{"text": " 4)合并有气胸、肺栓塞、肺炎等其他呼吸系统疾病。", "label": 4, "label_text": "Disease", "id": "s5604"}
{"text": "1）年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s5605"}
{"text": "近1年来经采用常规方法治疗后多次复查仍为阳性的霉菌性阴道炎患者作为研究对象；", "label": 5, "label_text": "Multiple", "id": "s5606"}
{"text": " 7.患者依从性良好，自愿按计划接受随诊、治疗、实验室检查以及其它研究步骤。", "label": 8, "label_text": "Compliance with Protocol", "id": "s5607"}
{"text": " 5、精神疾病、认真障碍者及不愿意合作者；", "label": 5, "label_text": "Multiple", "id": "s5608"}
{"text": " 8) 试验前3个月内参加过献血、试验献血或有过意外失血超过200 mL者；", "label": 14, "label_text": "Blood Donation", "id": "s5609"}
{"text": "(1)年龄18-70岁，性别不限。", "label": 5, "label_text": "Multiple", "id": "s5610"}
{"text": " 3.妊娠或哺乳期女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5611"}
{"text": " 体重50-100Kg", "label": 12, "label_text": "Laboratory Examinations", "id": "s5612"}
{"text": " 2.妊娠或哺乳期妇女，或准备妊娠妇女;", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5613"}
{"text": " 3）年龄大于40岁，小于80岁；", "label": 3, "label_text": "Age", "id": "s5614"}
{"text": " 3、脑外伤患者家属", "label": 4, "label_text": "Disease", "id": "s5615"}
{"text": " 3. 是否已行至少一种抗心律失常药物治疗而无效", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5616"}
{"text": " 3.2.2.8 急性心急梗死、深静脉血栓形成的患者；", "label": 4, "label_text": "Disease", "id": "s5617"}
{"text": " ②确诊毛细支气管炎，无其他严重并发症或合并症，住院接受治疗；", "label": 4, "label_text": "Disease", "id": "s5618"}
{"text": " 4.在3个月内参与其他类似的临床研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s5619"}
{"text": "①年龄≥18岁者；", "label": 3, "label_text": "Age", "id": "s5620"}
{"text": " 4.合并下肢水肿、右心衰竭和血流动力学不稳定等征象;", "label": 1, "label_text": "Sign", "id": "s5621"}
{"text": " 4.已知对研究药物的活性成分或辅料过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5622"}
{"text": " 3. 年龄40-75岁之间", "label": 3, "label_text": "Age", "id": "s5623"}
{"text": " 4、已发生远处转移", "label": 24, "label_text": "Neoplasm Status", "id": "s5624"}
{"text": " 3.无妊娠合并症；", "label": 4, "label_text": "Disease", "id": "s5625"}
{"text": " 5. 或者不愿意接受手术切除及局部治疗的组织学、细胞学或临床确诊的肝细胞癌患者", "label": 5, "label_text": "Multiple", "id": "s5626"}
{"text": " 3、自愿参加并已签署知情同意书", "label": 13, "label_text": "Consent", "id": "s5627"}
{"text": " ●既往卒中后遗症mRS评分≥2分；", "label": 5, "label_text": "Multiple", "id": "s5628"}
{"text": "  ?不能耐受新辅助化疗和相关治疗者：伴有未控制的肺部疾病、严重感染、活动性消化道溃疡需要治疗者、凝血功能障碍性疾病、结缔组织疾病或骨髓功能抑制等疾病；", "label": 5, "label_text": "Multiple", "id": "s5629"}
{"text": " 6.合并明显的肝肾功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5630"}
{"text": " 2. 18-45周岁", "label": 3, "label_text": "Age", "id": "s5631"}
{"text": " ④试验前15d发生腹泻；", "label": 4, "label_text": "Disease", "id": "s5632"}
{"text": " (5)在入组本试验前1个月内参加过其他临床试验的病例。", "label": 15, "label_text": "Enrollment in other studies", "id": "s5633"}
{"text": " 2.双上肺病变为主的非均质性肺气肿患者，高分辨CT（HRCT）测量的非均质性指数&gt;1.2；FEV1 &gt; 20% 且&lt; 45%预计值；", "label": 5, "label_text": "Multiple", "id": "s5634"}
{"text": "① 否认既往内科疾病史及经研究人员或医务人员排除合并冠心病、糖尿病、心、肝、肾疾病及继发性肥胖（库欣氏病、甲状腺功能减退症等）者；", "label": 4, "label_text": "Disease", "id": "s5635"}
{"text": " （3）难治性高血压（服用两种或两种以上降压药物治疗一个月以上，但收缩压仍持续高于160mmHg或舒张压仍持续高于100mmHg者）；", "label": 5, "label_text": "Multiple", "id": "s5636"}
{"text": " ④严重的心、肺、肝、肾等躯体疾病或严重的神经精神疾病。", "label": 4, "label_text": "Disease", "id": "s5637"}
{"text": " 知情同意者。", "label": 13, "label_text": "Consent", "id": "s5638"}
{"text": " ② 受试者及其监护人可以遵守试验相关规定，坚持按时随访", "label": 8, "label_text": "Compliance with Protocol", "id": "s5639"}
{"text": "1.18～35岁", "label": 3, "label_text": "Age", "id": "s5640"}
{"text": " b. 分期检查发现中枢神经系统包括脑，脊髓，眼，脑神经，和/或脑膜以外淋巴瘤侵犯的证据；", "label": 11, "label_text": "Diagnostic", "id": "s5641"}
{"text": " 2睡眠呼吸暂停综合征、睡眠周期性腿动、癫痫等", "label": 4, "label_text": "Disease", "id": "s5642"}
{"text": " 2.有保留子宫要求者", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5643"}
{"text": " 11.研究者认为患者不宜参加试验研究。", "label": 21, "label_text": "Researcher Decision", "id": "s5644"}
{"text": " 5）AVM患者要求无明确破裂出血史或出血一个月以上。", "label": 5, "label_text": "Multiple", "id": "s5645"}
{"text": " ?研究中发现可能增加患者风险或影响实验结果的情况；", "label": 21, "label_text": "Researcher Decision", "id": "s5646"}
{"text": " 1.创伤性脑损伤", "label": 4, "label_text": "Disease", "id": "s5647"}
{"text": "（1）预计合计植入3枚以上支架的患者；", "label": 34, "label_text": "Device", "id": "s5648"}
{"text": " 2.链霉蛋白酶颗粒过敏史患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5649"}
{"text": " 9.未治愈的恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s5650"}
{"text": " ②年龄18岁～70岁。", "label": 3, "label_text": "Age", "id": "s5651"}
{"text": " d)患者拒绝签署知情同意书，或估计依从性较差，随访可能性差者；", "label": 5, "label_text": "Multiple", "id": "s5652"}
{"text": " 6．筛选前一个月内开始、停止或者更改OAB药物/非药物治疗方案", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5653"}
{"text": " 4. 受试者知情同意，并签署相关文件", "label": 13, "label_text": "Consent", "id": "s5654"}
{"text": "1.符合特异性皮炎的临床诊断；", "label": 11, "label_text": "Diagnostic", "id": "s5655"}
{"text": " 4. 显著的再狭窄病变或者狭窄病变（直径大于等于2.5mm），需要行PCI或者CABG者。", "label": 5, "label_text": "Multiple", "id": "s5656"}
{"text": " (2) 已合并哮喘发作期，症状较重者。", "label": 5, "label_text": "Multiple", "id": "s5657"}
{"text": " (2) 研究期间脱失后再入组的患者。这是为了防止因重复纳入同一位研究对象而对效果评价产生偏倚。脱失是指无正当理由连续7天以上（含7天）或3个月内累计超过15天不参加维持治疗。", "label": 5, "label_text": "Multiple", "id": "s5658"}
{"text": " 2、普外科、妇科二级以上手术（包括开放手术、腔镜手术）", "label": 0, "label_text": "Therapy or Surgery", "id": "s5659"}
{"text": " 4.对生大黄过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s5660"}
{"text": "    ③  高危局部进展期前列腺癌患者（cT3b–T4, N0或任何T, N1, M0）同时预期寿命大于10年;", "label": 5, "label_text": "Multiple", "id": "s5661"}
{"text": "手部湿疹患者", "label": 4, "label_text": "Disease", "id": "s5662"}
{"text": " （7）器官移植术后或近期有严重的、反复性、慢性感染，包括HIV、肝炎、结核、梅毒等；", "label": 4, "label_text": "Disease", "id": "s5663"}
{"text": " ③外伤史等继发KOA者；", "label": 4, "label_text": "Disease", "id": "s5664"}
{"text": "1）符合偏头痛(有先兆偏头痛或无先兆偏头痛)诊断标准(即ICHD-3)；", "label": 11, "label_text": "Diagnostic", "id": "s5665"}
{"text": " G．合并非恶性肿瘤的严重疾病，将影响患者的依从性或使患者处于危险状态；", "label": 4, "label_text": "Disease", "id": "s5666"}
{"text": " 2.病人年龄18岁～50岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s5667"}
{"text": "1、全身和局部的任何活动性感染；", "label": 4, "label_text": "Disease", "id": "s5668"}
{"text": " ⑹研究者认为存在有不适合入选因素的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s5669"}
{"text": " 　b)引起体温降低的其他疾病：甲减、休克；", "label": 4, "label_text": "Disease", "id": "s5670"}
{"text": " 4. 合并全身疾病不能耐受口服激素和/或免疫抑制剂治疗；", "label": 5, "label_text": "Multiple", "id": "s5671"}
{"text": " 16、具有其他各种研究者认为不能加入此临床试验的情况", "label": 21, "label_text": "Researcher Decision", "id": "s5672"}
{"text": " 3）干眼症患者；", "label": 4, "label_text": "Disease", "id": "s5673"}
{"text": "1)研究员认定无法遵守研究程序", "label": 21, "label_text": "Researcher Decision", "id": "s5674"}
{"text": " 5）安全性试验室指标异常：肾功能；CR大于正常值上限；肝功能：ALT、AST&gt;1.5倍正常值上限者；", "label": 5, "label_text": "Multiple", "id": "s5675"}
{"text": "    ⑧自愿参加并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5676"}
{"text": "1.年龄在18岁以上；", "label": 3, "label_text": "Age", "id": "s5677"}
{"text": " ②近3个月接受过胸部、腹部和眼科手术者", "label": 0, "label_text": "Therapy or Surgery", "id": "s5678"}
{"text": " 5. 预期生存期≥3个月的患者；", "label": 23, "label_text": "Life Expectancy", "id": "s5679"}
{"text": " （3）在过去3个月内曾进行性激素替代疗法和口服避孕疗法；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5680"}
{"text": " 3.明确诊断为:慢性高原红细胞增多症患者.", "label": 11, "label_text": "Diagnostic", "id": "s5681"}
{"text": " (3)研究前未接受过HP治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5682"}
{"text": " （7）肝肾功能：总胆红素&gt;正常值上限(ULN)的1.5倍，天冬氨酸转氨酶（AST）、谷丙转氨酶（ALT）&gt;ULN的2.5 倍，血清肌酐&gt;正常值上限的1.5 倍，且肌酐清除率&lt; 60 ml/min；", "label": 5, "label_text": "Multiple", "id": "s5683"}
{"text": "   体力状况ECOG评分为0～1；", "label": 9, "label_text": "Risk Assessment", "id": "s5684"}
{"text": "1. 颌面部骨折外伤", "label": 4, "label_text": "Disease", "id": "s5685"}
{"text": " 2）确诊为恶性肿瘤或癌前病变的患者，非初诊患者前期诊断清楚，前期诊治方法规范，且有详细记录；", "label": 4, "label_text": "Disease", "id": "s5686"}
{"text": " 7. 开放性骨折；病理性骨折", "label": 4, "label_text": "Disease", "id": "s5687"}
{"text": " 3.同意治疗并参与本研究者。", "label": 13, "label_text": "Consent", "id": "s5688"}
{"text": " （3）糖尿病病史大于5年", "label": 4, "label_text": "Disease", "id": "s5689"}
{"text": " 3.重要器官有严重功能障碍，无法耐受手术", "label": 5, "label_text": "Multiple", "id": "s5690"}
{"text": " ?根据RECIST标准可测量的疾病", "label": 11, "label_text": "Diagnostic", "id": "s5691"}
{"text": "①年龄为28天至1周岁的先天性胆道闭锁患儿；", "label": 5, "label_text": "Multiple", "id": "s5692"}
{"text": " （3）重度高血压或高血压危险分层属高危或很高危者。", "label": 4, "label_text": "Disease", "id": "s5693"}
{"text": " （6）因精神、语言等因素而影响资料收集者；", "label": 22, "label_text": "Data Accessible", "id": "s5694"}
{"text": "1、任何严重的或未控制的的系统性疾病（不稳定的呼吸,心脏、肝脏或肾脏疾病或其他内部的严重疾病或未控制的感染）", "label": 4, "label_text": "Disease", "id": "s5695"}
{"text": " 3、DSA提示颈内动脉、大脑中动脉主干急性闭塞；", "label": 11, "label_text": "Diagnostic", "id": "s5696"}
{"text": " 2.年龄18—70岁患者。", "label": 3, "label_text": "Age", "id": "s5697"}
{"text": " 3 既往行青光眼或白内障手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5698"}
{"text": " 2. 经过二线治疗失败或复发的NSCLC患者；", "label": 5, "label_text": "Multiple", "id": "s5699"}
{"text": " (9)需进行西医系统治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5700"}
{"text": "1.符合膝骨关节炎西医诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s5701"}
{"text": " 3.极重度肺动脉瓣狭窄或室间隔完整的肺动脉瓣闭锁合并右心室依赖性冠状动脉循环；", "label": 4, "label_text": "Disease", "id": "s5702"}
{"text": " ⑧已知对该研究中某种药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5703"}
{"text": " 5.根据GCP和当地法规，访视1时签署知情同意书并注明日期。", "label": 13, "label_text": "Consent", "id": "s5704"}
{"text": "（1）多发肿瘤；", "label": 4, "label_text": "Disease", "id": "s5705"}
{"text": " C.对于考虑存在远处转移瘤的患者，躯干转移瘤需经过CT检查证实，骨转移瘤需经全身骨扫描证实，脑转移瘤需经MRI检查证实存在典型转移瘤影像学特征的肿物。", "label": 5, "label_text": "Multiple", "id": "s5706"}
{"text": " 6．具有严重的原发性心、肝、肺、肾、血液或影响其生存的严重疾病，如肿瘤或艾滋病；肾功能异常；尿蛋白＞＋，镜下尿红细胞＞＋（尿Hb不作为判断指标）；ALT＞2N（N为正常值上限）；有临床意义的心电图异常；血白细胞＜3.0×109/L；TC＞8.0 mmol/L；TG ＞6.0mmol/L；", "label": 5, "label_text": "Multiple", "id": "s5707"}
{"text": " 10.不适合做磁共振检查者（幽闭症、带有心脏起搏器、金属避孕环等）；", "label": 5, "label_text": "Multiple", "id": "s5708"}
{"text": " A、经第四军医大学伦理委员会同意，全体参加者签署书面知情同意书；", "label": 5, "label_text": "Multiple", "id": "s5709"}
{"text": "①有其他癌症病史；", "label": 4, "label_text": "Disease", "id": "s5710"}
{"text": " ④术后GCS3分；", "label": 9, "label_text": "Risk Assessment", "id": "s5711"}
{"text": " ⑧不愿合作者；", "label": 13, "label_text": "Consent", "id": "s5712"}
{"text": " 25.受试者可能因为其他原因而不能完成本研究或经研究者判断具有其它不宜参加试验原因者。", "label": 21, "label_text": "Researcher Decision", "id": "s5713"}
{"text": " (2)无法签署书面知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5714"}
{"text": " 3）有明显出血倾向和血液性疾病的患者。", "label": 5, "label_text": "Multiple", "id": "s5715"}
{"text": " 10)心电图正常；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5716"}
{"text": " 3. 在过去五年内有药品滥用史；", "label": 2, "label_text": "Addictive Behavior", "id": "s5717"}
{"text": " 左室射血分数&lt;40%;", "label": 12, "label_text": "Laboratory Examinations", "id": "s5718"}
{"text": "1.失语、视听障碍患者。", "label": 4, "label_text": "Disease", "id": "s5719"}
{"text": "（1）初诊为肺癌伴胸腔积液的患者；", "label": 4, "label_text": "Disease", "id": "s5720"}
{"text": "1.组织学确诊的胃癌，根据超声内镜及增强 CT/MRI 检查进行临床分期，分期为cT4aN+M0，或 cT4bNanyM0， 或cTxNxM1c （16组淋巴结转移）。", "label": 5, "label_text": "Multiple", "id": "s5721"}
{"text": " 10)已知或怀疑对研究药品过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5722"}
{"text": " 3.既往无长期高原暴露史", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5723"}
{"text": "1.等候手术切除或肝移植者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5724"}
{"text": " 5. 个人知情同意该项实验性的治疗", "label": 13, "label_text": "Consent", "id": "s5725"}
{"text": " （3）有严重、未控制的器质性病变或感染，如失代偿的心、肺、肾功能衰竭等导致不能耐受化疗的患者；", "label": 5, "label_text": "Multiple", "id": "s5726"}
{"text": " （2）COPD等肺部基础疾病患者;", "label": 4, "label_text": "Disease", "id": "s5727"}
{"text": " 3.受试者的血清激素值在正常范围内（包含黄体生成素、卵泡刺激素、泌乳素、雄激素和雌二醇）。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5728"}
{"text": " 10)甲状腺功能低下者；", "label": 4, "label_text": "Disease", "id": "s5729"}
{"text": " (3)孕妇及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5730"}
{"text": " 3.年龄在18-75周岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s5731"}
{"text": " 6)既往有过穴位刺激治疗经历或对穴位刺激不敏感者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5732"}
{"text": " 6、脑转移或脑膜转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s5733"}
{"text": "1晕针志愿者；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5734"}
{"text": "1.年龄》18岁；", "label": 3, "label_text": "Age", "id": "s5735"}
{"text": " （3）18岁≤年龄≤75岁；", "label": 3, "label_text": "Age", "id": "s5736"}
{"text": " 15)病毒性肝炎（包括乙肝和丙肝）、艾滋病抗体、梅毒螺旋体抗体筛选阳性。", "label": 4, "label_text": "Disease", "id": "s5737"}
{"text": " 5.既往迷走神经功能紊乱", "label": 4, "label_text": "Disease", "id": "s5738"}
{"text": " 4. 本次复发前使用羟基喜树碱膀胱灌注", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5739"}
{"text": " 2.有癫痫家族史；", "label": 4, "label_text": "Disease", "id": "s5740"}
{"text": "本研究是一个前瞻性、随机、单盲、对照试验。自2015年7月－2015年12月，于天津市第三中心医院心脏中心住院并接受直接ＰＣＩ治疗的连续ASTEMI患者，按照1:1随机进入试验组(缺血后处理组) 或对照组。", "label": 5, "label_text": "Multiple", "id": "s5741"}
{"text": " ⑤无外用中药过敏史患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s5742"}
{"text": "●不配合随访，治疗依从性差者", "label": 8, "label_text": "Compliance with Protocol", "id": "s5743"}
{"text": " 3.需要急症行颅内血肿清除的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5744"}
{"text": " 3.患者既往3年内或同时患有其它恶性肿瘤（已治愈的皮肤基底细胞癌和宫颈原位癌除外）；", "label": 4, "label_text": "Disease", "id": "s5745"}
{"text": " （4）试验前3个月内参加过其他药物临床试验等；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5746"}
{"text": "1、年龄18-80岁；", "label": 3, "label_text": "Age", "id": "s5747"}
{"text": " 2. 知情同意", "label": 13, "label_text": "Consent", "id": "s5748"}
{"text": " （5）正在参加或最近30天内参加过另一项临床研究；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5749"}
{"text": " （4）孕妇", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5750"}
{"text": " 2.患有上下呼吸道感染和其他器质性疾病；", "label": 4, "label_text": "Disease", "id": "s5751"}
{"text": " （4）合并严重的心脑血管疾病、肝、肾、血液系统疾病患者或恶性肿瘤，精神病患者、糖尿病患者，HIV患者、有出血倾向的患者", "label": 4, "label_text": "Disease", "id": "s5752"}
{"text": "1. 符合以下任一条的毛细支气管炎重症患儿：①出现休克或意识障碍；②合并呼吸衰竭征象；③反复呼吸暂停或出现慢而不规", "label": 5, "label_text": "Multiple", "id": "s5753"}
{"text": "1）过去1年与男性性伴存在肛交/口交性行为；", "label": 37, "label_text": "Sexual related", "id": "s5754"}
{"text": " ③正患有其他恶性肿瘤，需要治疗者；", "label": 4, "label_text": "Disease", "id": "s5755"}
{"text": " （1）年龄18-40岁之间女性患者；", "label": 5, "label_text": "Multiple", "id": "s5756"}
{"text": " 6. 4周内参加过其他临床试验的或正在参加其他药物临床试验的患儿；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5757"}
{"text": " CI8. 受试者同意配合所有的随访检查。", "label": 8, "label_text": "Compliance with Protocol", "id": "s5758"}
{"text": " （20）患者目前存在药物滥用问题（例如酒精等）", "label": 2, "label_text": "Addictive Behavior", "id": "s5759"}
{"text": " 6. HIV，HBV，HCV检测阳性的患者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5760"}
{"text": " 4.近2年内有移居外地计划；", "label": 40, "label_text": "Address", "id": "s5761"}
{"text": " 5) 合并心、肺、肝、肾造血系统、内分泌系统等严重原发性疾病或精神病患者；", "label": 4, "label_text": "Disease", "id": "s5762"}
{"text": "（1）原发性开角型青光眼或原发闭角型青光眼；", "label": 4, "label_text": "Disease", "id": "s5763"}
{"text": " 7.初诊时未行肿瘤细胞减灭术的育龄妇女必须在入组前7天内进行妊娠试验（血清），且结果为阴性，并且愿意在试验期间和末次给予试验药物后8周内采用适当的方法避孕；", "label": 5, "label_text": "Multiple", "id": "s5764"}
{"text": " 2)既往糖尿病以及用药史。", "label": 5, "label_text": "Multiple", "id": "s5765"}
{"text": " 9)最近在饮食或运动习惯上有重大变化；", "label": 5, "label_text": "Multiple", "id": "s5766"}
{"text": " ②急诊手术患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5767"}
{"text": "(1)受试者年龄40-80岁", "label": 3, "label_text": "Age", "id": "s5768"}
{"text": "1.有严重的心血管、肝、肾和造血系统等原发性疾病；合并有精神病及严重癫痫", "label": 4, "label_text": "Disease", "id": "s5769"}
{"text": " （5）患者和家属自愿为观察对象并填写知情同意书。", "label": 13, "label_text": "Consent", "id": "s5770"}
{"text": " 6.患儿父母或其他法定监护人知情同意，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5771"}
{"text": " 15)校正QT间期＞ 470msec；如果患者存在QT间期延长，但研究者研究评估延长的原因为心脏起搏器（且无心脏其他异常），需要与申办方研究医师讨论后决定患者是否为适合入组研究", "label": 5, "label_text": "Multiple", "id": "s5772"}
{"text": " NISS评分小于5分或大于20分", "label": 9, "label_text": "Risk Assessment", "id": "s5773"}
{"text": " 4. 未参加其他临床研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s5774"}
{"text": " 3、颅内多发性出血", "label": 1, "label_text": "Sign", "id": "s5775"}
{"text": " ⑤同意进行左房去神经化治疗。同意参加临床试验并签署知情同意书，并同意按照验证方案要求进行随防评价。", "label": 5, "label_text": "Multiple", "id": "s5776"}
{"text": " (2) 患者伴有严重的内外科合并疾病，包括心血管疾病、呼吸系统疾病、泌尿系统疾病、代谢性疾病、恶性肿瘤等；", "label": 4, "label_text": "Disease", "id": "s5777"}
{"text": " （4）病情属稳定期；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s5778"}
{"text": " ①主诉为勃起硬度下降、维持勃起困难及初次性交失败 3 个月及以上", "label": 1, "label_text": "Sign", "id": "s5779"}
{"text": " 3) 已行影像学评估；", "label": 11, "label_text": "Diagnostic", "id": "s5780"}
{"text": " ③自愿签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5781"}
{"text": " （7）患者知情同意。", "label": 13, "label_text": "Consent", "id": "s5782"}
{"text": " 4.耳部感染", "label": 4, "label_text": "Disease", "id": "s5783"}
{"text": " 4、患者已完全了解该研究性质，自愿参加本试验并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s5784"}
{"text": " 4. 急性胃或十二指肠溃疡；", "label": 4, "label_text": "Disease", "id": "s5785"}
{"text": " 5)合并有其他严重的并发症患者；", "label": 4, "label_text": "Disease", "id": "s5786"}
{"text": "1、行动不变，或有严重颈腰椎疾病不能运动者", "label": 27, "label_text": "Exercise", "id": "s5787"}
{"text": " 7.体检时完成KOOS、VAS等膝关节症状主观评估；", "label": 9, "label_text": "Risk Assessment", "id": "s5788"}
{"text": " ⑥无主要器官的功能障碍，心、肝、肾功能基本正常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5789"}
{"text": " （2）收缩压＞140mmHg 和（或）舒张压＞90mmHg", "label": 12, "label_text": "Laboratory Examinations", "id": "s5790"}
{"text": " 3)长期服用成瘾性药物如某些镇静止痛药，抗精神病药物，抗癫痫药物等；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5791"}
{"text": " 2.AST和/或ALT&gt;2.5×ULN。", "label": 12, "label_text": "Laboratory Examinations", "id": "s5792"}
{"text": "组织学检查确诊原发性非小细胞肺癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s5793"}
{"text": " 4)体重指数：20-25 kg/m2范围；", "label": 9, "label_text": "Risk Assessment", "id": "s5794"}
{"text": " (2) 年龄 ≥ 30岁；", "label": 3, "label_text": "Age", "id": "s5795"}
{"text": " 5）患有除APL外其它需要治疗的恶性肿瘤的患者。", "label": 4, "label_text": "Disease", "id": "s5796"}
{"text": " 9、肝癌术前未行相关治疗，手术为肝癌根治性切除，术后病理组织学活检结果为HCC", "label": 0, "label_text": "Therapy or Surgery", "id": "s5797"}
{"text": " 7. 自身免疫性疾病、消化性溃疡、贫血、克罗恩病、急性感染性疾病等。", "label": 4, "label_text": "Disease", "id": "s5798"}
{"text": " 5 软骨损伤大于2级", "label": 9, "label_text": "Risk Assessment", "id": "s5799"}
{"text": " 10. FS-LASIK术后1周复查时，未伴随其他术后眼部并发症者。", "label": 4, "label_text": "Disease", "id": "s5800"}
{"text": " 18)筛选时空腹血糖值&gt;13.9mmol/L，或HbA1c&gt;10.5%或&lt;7.0%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5801"}
{"text": " 5、女性患者妊娠检查阴性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5802"}
{"text": " ⑵KPS评分≥70分；", "label": 9, "label_text": "Risk Assessment", "id": "s5803"}
{"text": " 10）预期生存期&gt;3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s5804"}
{"text": " 4)伴肾性贫血者；", "label": 4, "label_text": "Disease", "id": "s5805"}
{"text": " 17.精神病、严重心脏病患者；", "label": 4, "label_text": "Disease", "id": "s5806"}
{"text": " (2)术前有精神分裂症、癫痫、帕金森症、重症肌无力", "label": 4, "label_text": "Disease", "id": "s5807"}
{"text": " （2）烧伤后4小时内入院；", "label": 4, "label_text": "Disease", "id": "s5808"}
{"text": " 8)活动期的高于常见不良事件评价标准（CTCAE）2级的临床严重感染；", "label": 9, "label_text": "Risk Assessment", "id": "s5809"}
{"text": " （3）诊断有增生性糖尿病性视网膜病变；", "label": 4, "label_text": "Disease", "id": "s5810"}
{"text": " 2.继发孔型ASD直径≥5mm，伴右心容量负荷增加，≤36mm的左向右分流ASD。", "label": 5, "label_text": "Multiple", "id": "s5811"}
{"text": " 6.孕妇及哺乳者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5812"}
{"text": " i．男女均可，年龄不限，", "label": 5, "label_text": "Multiple", "id": "s5813"}
{"text": " ⑦能理解本研究的情况，能够配合进行CIPN分级的评估，并已签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5814"}
{"text": " 2.年龄18~60周岁（包括临界值），性别不限；", "label": 5, "label_text": "Multiple", "id": "s5815"}
{"text": " e、妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5816"}
{"text": "   ⑦患者知情同意。", "label": 13, "label_text": "Consent", "id": "s5817"}
{"text": " 9.对质子泵抑制剂过敏史。", "label": 7, "label_text": "Allergy Intolerance", "id": "s5818"}
{"text": " （3）实验室检查者：血常规、尿常规、肝肾功能等检查正常，及心电图检查正常，能够耐受玻璃体切除手术", "label": 5, "label_text": "Multiple", "id": "s5819"}
{"text": " 6.心脏肝脏肾脏功能正常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5820"}
{"text": " 10、没有精神病 (也不属于以下情况：使用抗精神病药物的如氯氮平、利培酮、喹硫平、吩噻嗪或butyrophen 已经使用30天，或者需要在研究期间继续使用;长期使用吩噻嗪等抗精神类药物。但是，如果氯吡嗪或其他的吩噻嗪药物作为解救性治疗是可以的)。", "label": 5, "label_text": "Multiple", "id": "s5821"}
{"text": " 7、无植入禁忌者；", "label": 4, "label_text": "Disease", "id": "s5822"}
{"text": " （12）血清肌酐≤1.5倍正常参考值上限", "label": 12, "label_text": "Laboratory Examinations", "id": "s5823"}
{"text": " 4）心肺功能严重不全；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5824"}
{"text": " 6.经常使用中草药、安眠药、镇静剂、安定剂、或其他成瘾性药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5825"}
{"text": " 3. 根据中国高血压防治指南2005年修订版的诊断标准（见附录1），诊断为中低危原发性高血压的患者；", "label": 11, "label_text": "Diagnostic", "id": "s5826"}
{"text": " d) 严重心、肺、肝肾功能不全及凝血功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5827"}
{"text": " 4) 患者存在结缔组织疾病、感染性动脉瘤及其他部位活动性感染。", "label": 4, "label_text": "Disease", "id": "s5828"}
{"text": " 2. 糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s5829"}
{"text": " 5. 患有Ⅱ级以上心肌缺血或心肌梗塞、控制不良的心律失常", "label": 4, "label_text": "Disease", "id": "s5830"}
{"text": " 5.肝、肾功能不全患者：血清胆红素（SB）≥2mg/dl，AST＞正常上限2.5倍，血清肌酐（SCr）＞2.5mg/dl", "label": 5, "label_text": "Multiple", "id": "s5831"}
{"text": " 5.自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5832"}
{"text": "（1）流动工人：指进入城镇务工的非流入地户口人员；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5833"}
{"text": " （7）近期使用激素类药物避孕者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5834"}
{"text": " (4)动脉血氧合功能异常：站立位、静息状态下血气分析PO2&lt;80 mmHg 且P(A-a)O2≥15 mmHg （大于64岁的老年人≥20 mmHg）；", "label": 5, "label_text": "Multiple", "id": "s5835"}
{"text": " （9）自身免疫性疾病或任何严重致命性疾病；", "label": 4, "label_text": "Disease", "id": "s5836"}
{"text": " 4、预期寿命不足10年。", "label": 23, "label_text": "Life Expectancy", "id": "s5837"}
{"text": " ④有高血压及心血管疾病病史；", "label": 4, "label_text": "Disease", "id": "s5838"}
{"text": " 2. 年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s5839"}
{"text": " 8、影响呼吸运动功能的神经肌肉疾病；", "label": 4, "label_text": "Disease", "id": "s5840"}
{"text": "  (5)能够理解本研究的程序和方法，愿意严格遵守临床试验方案完成本试验，并自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5841"}
{"text": " ii 非动脉粥样硬化性血栓性脑梗死(如心源性栓塞、易凝状态、血管内膜脱落、动脉炎等)；", "label": 4, "label_text": "Disease", "id": "s5842"}
{"text": " 2.炎症、结核等非肿瘤性病变；", "label": 4, "label_text": "Disease", "id": "s5843"}
{"text": " （2） 年龄18～75岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s5844"}
{"text": " 患者基础LH，FSH和PRL水平无异常", "label": 12, "label_text": "Laboratory Examinations", "id": "s5845"}
{"text": " 有严重腹泻或者呕吐，活动性上消化道溃疡或吸收不良", "label": 5, "label_text": "Multiple", "id": "s5846"}
{"text": " (10) 其它由研究者判断不适合进入本研究者；", "label": 21, "label_text": "Researcher Decision", "id": "s5847"}
{"text": " （8）研究者认为应排除在本研究之外的其他任何情况。", "label": 21, "label_text": "Researcher Decision", "id": "s5848"}
{"text": " 5.受试者的女伴经检查是可正常怀孕的。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5849"}
{"text": "a.中国公民，男性,年龄25-40岁; 身高162-175cm，体重指数（BMI）18.5～24.9；", "label": 5, "label_text": "Multiple", "id": "s5850"}
{"text": " 9.研究者认为有可能影响研究评估的其他任何情况者。", "label": 21, "label_text": "Researcher Decision", "id": "s5851"}
{"text": " 2.诊断为急性心力衰竭的住院患者；", "label": 11, "label_text": "Diagnostic", "id": "s5852"}
{"text": " （8）伴有活动性胃肠道疾病的患者，以及本研究前30天内有食道或消化道溃疡的患者（既往有消化道出血病史的患者不在排除之列）。", "label": 4, "label_text": "Disease", "id": "s5853"}
{"text": "1.符合绝经的定义；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5854"}
{"text": " （4）急性心肌梗死病史；", "label": 4, "label_text": "Disease", "id": "s5855"}
{"text": " 6）有第8对脑神经损害，重症肌无力或帕金森病史。", "label": 4, "label_text": "Disease", "id": "s5856"}
{"text": " 13、血清钠≤125mmol/L或≥160mmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5857"}
{"text": " 6）24小时内使用过镇痛药、维生素；1个月内使用过抗生素，3个月内全身使用过皮质类固醇激素、免疫调节剂者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5858"}
{"text": " （15）受试者血白细胞＜3.0×109/L，或有明确的贫血（血红蛋白小于80g/L），或血小板＜80×109/L，或有其他血液系统疾病者；活动性肝病或肝功能异常（谷丙转氨酶(ALT)、谷草转氨酶(AST)或胆红素&gt;正常值上限）的患者。", "label": 5, "label_text": "Multiple", "id": "s5859"}
{"text": "（1）筛选访视前6个月内出现过心肌梗死、卒中、短暂性脑缺血发作、心血管手术或者大手术病史。", "label": 5, "label_text": "Multiple", "id": "s5860"}
{"text": " 6．使用影响本课题实验观察的其他药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5861"}
{"text": " （2）患有周围神经病变者；", "label": 4, "label_text": "Disease", "id": "s5862"}
{"text": " 2.年龄18-65岁", "label": 3, "label_text": "Age", "id": "s5863"}
{"text": " （2）无运动系统障碍的患者；", "label": 4, "label_text": "Disease", "id": "s5864"}
{"text": " 6)合并肝肾功能损害者：ALT、AST超过正常值上限的1.5倍，Cr超过正常值上限，TBIL超过正常值上限的2倍；", "label": 5, "label_text": "Multiple", "id": "s5865"}
{"text": "1.符合《国际疾病分类与诊断标准》（ICD-10）抑郁轻度、中度发作（F32）的诊断标准，首次诊断，未经系统治疗，病程2周-1年。", "label": 11, "label_text": "Diagnostic", "id": "s5866"}
{"text": " （12）其他由研究者判断不适宜参加本临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s5867"}
{"text": " 6.LDCT筛查必须至少有一个可测量的肺部小结节", "label": 12, "label_text": "Laboratory Examinations", "id": "s5868"}
{"text": " 6  同时接受其他临床研究的试验性治疗（处于临床研究的治疗期）；", "label": 15, "label_text": "Enrollment in other studies", "id": "s5869"}
{"text": " 2.成年人（年龄≥18周岁）", "label": 3, "label_text": "Age", "id": "s5870"}
{"text": "  发育性颈椎管狭窄症。", "label": 4, "label_text": "Disease", "id": "s5871"}
{"text": " ①直径大于2 cm的梗死灶大于2个，或HIS总分&gt;4分；", "label": 5, "label_text": "Multiple", "id": "s5872"}
{"text": " 获得患者，父亲或母亲，或代理人的知情同意权。", "label": 13, "label_text": "Consent", "id": "s5873"}
{"text": " 4.因治疗需要，需同时使用全身性类固醇药物(强的松超过0.5 mg/kg/day) 的患者。近期或正在使用吸入型类固醇不需要被排除；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5874"}
{"text": " 3.长期使用抗炎制剂或药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5875"}
{"text": "（1）&gt;50岁；", "label": 3, "label_text": "Age", "id": "s5876"}
{"text": " 3、有其他肌肉、关节或神经方面的情况影响膝关节功能；", "label": 5, "label_text": "Multiple", "id": "s5877"}
{"text": " （3）诊断符合1995年全国第四届脑血管病学术会议通过的各类脑血管病诊断要点", "label": 11, "label_text": "Diagnostic", "id": "s5878"}
{"text": " （5）3个月内精神类药物应用史。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5879"}
{"text": " 2.参加者或监护人充分了解试验内容，愿意参加实验， 已签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s5880"}
{"text": " （4）在该省长期居住的人员；", "label": 40, "label_text": "Address", "id": "s5881"}
{"text": " - 签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s5882"}
{"text": " 3、术前应用呼吸机；", "label": 34, "label_text": "Device", "id": "s5883"}
{"text": " （3）手术前半年内接受过永久性或暂时性的泪点栓塞。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5884"}
{"text": " 13.研究者认为不适合入组者。", "label": 21, "label_text": "Researcher Decision", "id": "s5885"}
{"text": "（1）未治疗脑转移或者3个月内治疗过的脑转移患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5886"}
{"text": " [4]生命体征不正常，以及不能配合检查者；", "label": 5, "label_text": "Multiple", "id": "s5887"}
{"text": " ④.术前术后有动静脉血栓患者。", "label": 4, "label_text": "Disease", "id": "s5888"}
{"text": "（1） 妊娠及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5889"}
{"text": " 2.责任病灶位于脑干或小脑;", "label": 4, "label_text": "Disease", "id": "s5890"}
{"text": " 2.无基础疾病", "label": 4, "label_text": "Disease", "id": "s5891"}
{"text": " 3.合并有急性冠脉综合症者；", "label": 4, "label_text": "Disease", "id": "s5892"}
{"text": " 2、病情程度属于极重度COPD稳定期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s5893"}
{"text": "1. 其他原因导致的膀胱及排尿功能障碍", "label": 4, "label_text": "Disease", "id": "s5894"}
{"text": " 3)手术前未经过放疗、化疗的治疗措施；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5895"}
{"text": " 4. 孕妇、哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5896"}
{"text": " (2) 严重的先天性心脏病、心肌梗死后遗症、肥厚性心肌病、扩张性心肌病等器质性心脏病史者", "label": 4, "label_text": "Disease", "id": "s5897"}
{"text": " （1）糖尿病性溃疡恶变者；", "label": 4, "label_text": "Disease", "id": "s5898"}
{"text": " 3) 签署知情同意书", "label": 13, "label_text": "Consent", "id": "s5899"}
{"text": " 6.现在使用全身激素治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s5900"}
{"text": " V.术后16小时内排气排便；", "label": 1, "label_text": "Sign", "id": "s5901"}
{"text": " 6. 经全面体检（包括一般检查、血尿常规、血生化检查、胸部X线、B超及心电图等）无严重的肝、肾功能损害且其他指标在基本正常范围者；", "label": 5, "label_text": "Multiple", "id": "s5902"}
{"text": " 2、年龄在30-50岁;", "label": 3, "label_text": "Age", "id": "s5903"}
{"text": " ⑤无法控制的感染；", "label": 4, "label_text": "Disease", "id": "s5904"}
{"text": "①合并严重心、脑、肝、肾疾病的患儿；", "label": 4, "label_text": "Disease", "id": "s5905"}
{"text": " 3.育龄妇女在给药开始前血妊娠试验阴性，并同意在整个研究期间采取有效的避孕措施者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5906"}
{"text": " ②初始治疗患者，术前未接受过化疗等抗肿瘤治疗，有胃癌根治性手术指征；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5907"}
{"text": "1）不受控的阳性感染乙肝或丙肝阳性", "label": 4, "label_text": "Disease", "id": "s5908"}
{"text": "（1）继发性高血压患者", "label": 4, "label_text": "Disease", "id": "s5909"}
{"text": " (4)免知情同意，愿意接受随访。", "label": 5, "label_text": "Multiple", "id": "s5910"}
{"text": "① 2014年-2016年间因附件肿物来我院就诊；", "label": 26, "label_text": "Encounter", "id": "s5911"}
{"text": " (3)患有除屈光度异常之外需要治疗的眼部疾病者（因使用角膜接触镜而接受人工泪液型滴眼液者除外）", "label": 5, "label_text": "Multiple", "id": "s5912"}
{"text": " 5) 异体器官移植史", "label": 0, "label_text": "Therapy or Surgery", "id": "s5913"}
{"text": " 2.1.6自愿参加临床试验，并签署知情同意书者；", "label": 13, "label_text": "Consent", "id": "s5914"}
{"text": " 8. 临床上严重的心脏病（NYHA）II 级或更严重的充血性心力衰竭或严重的需要药物干预的心律失常；", "label": 4, "label_text": "Disease", "id": "s5915"}
{"text": " 6.有出血风险患者，活动性溃疡或消化道出血病史者；", "label": 4, "label_text": "Disease", "id": "s5916"}
{"text": " (4)含职业暴露因素（如油漆，装修，美甲行业等）及血液相关疾病。", "label": 4, "label_text": "Disease", "id": "s5917"}
{"text": "1  病理证实的WHO II型或III型鼻咽癌；", "label": 11, "label_text": "Diagnostic", "id": "s5918"}
{"text": " 2．肾移植术后患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5919"}
{"text": " 存在远处转移（肝、肾、骨、脑）", "label": 24, "label_text": "Neoplasm Status", "id": "s5920"}
{"text": " 3合并明显的肝肾功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5921"}
{"text": " 2、出院时服用除阿托伐他汀以外的其他他汀类药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5922"}
{"text": " 4）肝、肾功能不全：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5923"}
{"text": " 5.手术体位为侧卧位或俯卧位者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5924"}
{"text": " 5.卒中临床表现持续至少30分钟，在治疗前未有明显改善。", "label": 5, "label_text": "Multiple", "id": "s5925"}
{"text": " （3）COPD急性加重风险评估为高风险（在过去1年中急性加重次数≥2次或上一年因急性加重住院≥1次）；", "label": 9, "label_text": "Risk Assessment", "id": "s5926"}
{"text": "排除其他美国精神疾病诊断和统计手册第 IV 版（DSM-IV）中的精神疾病诊断；", "label": 11, "label_text": "Diagnostic", "id": "s5927"}
{"text": " 2.一般情况较差，出现了脓毒血症或感染性休克等症状。", "label": 5, "label_text": "Multiple", "id": "s5928"}
{"text": " （4）发病后已使用过治疗本病的其他药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5929"}
{"text": " 2、其他系统性神经疾病所致的吞咽功障碍者，头颈部恶性肿瘤所致吞咽功能障碍者；", "label": 4, "label_text": "Disease", "id": "s5930"}
{"text": " 11.可获得患者基线数据和之前的治疗数据", "label": 22, "label_text": "Data Accessible", "id": "s5931"}
{"text": " (5) 存在椎管内麻醉禁忌症者；", "label": 4, "label_text": "Disease", "id": "s5932"}
{"text": " 4.目前诊断为非轻、中度寻常型银屑病者（皮损面积超过其总体表面积的10%）；", "label": 4, "label_text": "Disease", "id": "s5933"}
{"text": " （3）自愿接受该方案治疗，并签署知情同意书，知情同意过程符合GCP要求。", "label": 13, "label_text": "Consent", "id": "s5934"}
{"text": "1 有不典型帕金森综合征的证据或是诊断，例如：路易体痴呆、多系统萎缩，进行性核上行麻痹，皮质基底节变性等；", "label": 5, "label_text": "Multiple", "id": "s5935"}
{"text": " 8.具有出血倾向或正在接受溶栓或抗凝治疗；", "label": 5, "label_text": "Multiple", "id": "s5936"}
{"text": "（1）妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5937"}
{"text": " （5）正在参加其它药物临床试验者或1个月内参加过其它临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s5938"}
{"text": " （5）自愿参加研究并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s5939"}
{"text": " 3.暴露日&gt;100天；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s5940"}
{"text": "①既往或目前有精神病史，不能接受跟踪随访者；", "label": 5, "label_text": "Multiple", "id": "s5941"}
{"text": "(1)ASA分级Ⅰ或Ⅱ级；", "label": 9, "label_text": "Risk Assessment", "id": "s5942"}
{"text": " 2) 对双膦酸盐类药物或本品所含其他成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5943"}
{"text": " （6）手术区伤口感染或近期血培养细菌呈阳性的患者；", "label": 4, "label_text": "Disease", "id": "s5944"}
{"text": " ● 目前或曾经发生至少3个月的慢性背痛 (CBP)，且发病时的年龄小于45岁**", "label": 5, "label_text": "Multiple", "id": "s5945"}
{"text": " （6）神志清楚，能够理解并配合干预方式及内容，无听力及语言交流障碍；", "label": 5, "label_text": "Multiple", "id": "s5946"}
{"text": " 5）既往曾经有妇科腹腔镜或者ART治疗经历", "label": 0, "label_text": "Therapy or Surgery", "id": "s5947"}
{"text": " 4.经过NRS2002营养风险筛查，NRS2002≥3分；", "label": 9, "label_text": "Risk Assessment", "id": "s5948"}
{"text": " 4.严重高钾血症（ K+ &gt;7.0mmol/L）", "label": 5, "label_text": "Multiple", "id": "s5949"}
{"text": " 6.完全肠梗阻患者经积极保守治疗，仍无法耐受全量肠内营养者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s5950"}
{"text": " 2、以CKD-EPI公式估算肾小球滤过率，根据K/DOQI指南， eGFR≤59mL/(min·1.73m2)定义为慢性肾脏病3a—5期；", "label": 5, "label_text": "Multiple", "id": "s5951"}
{"text": "有创呼吸机辅助呼吸通气大于48h 的存在膈肌功能障碍的成年患者（年龄大于18岁），且满足撤机前以下筛查条件：", "label": 5, "label_text": "Multiple", "id": "s5952"}
{"text": " 8. 既往曾服用DHEA等雄激素制剂者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5953"}
{"text": " 6）研究者认为不宜参加研究的其他情况；", "label": 21, "label_text": "Researcher Decision", "id": "s5954"}
{"text": " 2)  曾患或正在并发其他恶性肿瘤；", "label": 4, "label_text": "Disease", "id": "s5955"}
{"text": " 患有全身性神经肌肉接头疾病（如肌萎缩侧索硬化症、重症肌无力、Lambert-Eaton综合征等）", "label": 4, "label_text": "Disease", "id": "s5956"}
{"text": " （4）已完善入院辅助检查；", "label": 12, "label_text": "Laboratory Examinations", "id": "s5957"}
{"text": " 4）年龄20周岁-60岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s5958"}
{"text": " 5. 糖尿病合并下肢破溃者。", "label": 4, "label_text": "Disease", "id": "s5959"}
{"text": " 7. 研究过程中不愿或不能依从研究方案；", "label": 8, "label_text": "Compliance with Protocol", "id": "s5960"}
{"text": " 2)年龄&gt; 18岁；", "label": 3, "label_text": "Age", "id": "s5961"}
{"text": " （2） 分期为T1-4N2-3M0或T4N0-1M0(UICC 8th edition)且治疗前EB-DNA≥1500IU/L；", "label": 5, "label_text": "Multiple", "id": "s5962"}
{"text": " 2)接受过诊断为粘液性、透明细胞亚型的上皮性卵巢癌，癌肉瘤或未分化卵巢癌", "label": 11, "label_text": "Diagnostic", "id": "s5963"}
{"text": "年龄≥18岁，性别不限", "label": 5, "label_text": "Multiple", "id": "s5964"}
{"text": " （3）心功能低下（超声EF&lt;30%）；", "label": 5, "label_text": "Multiple", "id": "s5965"}
{"text": "1. 曾行膝关节镜或人工膝关节置换手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s5966"}
{"text": "(1)复发性胰腺炎；", "label": 4, "label_text": "Disease", "id": "s5967"}
{"text": " 严重的系统性疾病，预计存活不到3个月", "label": 5, "label_text": "Multiple", "id": "s5968"}
{"text": " （4）年龄在45-74岁之间的中老年患者；", "label": 3, "label_text": "Age", "id": "s5969"}
{"text": "  B.影像学检查（B超）确诊为单囊型（CE1）或多子囊型（CE2）、或内囊塌陷坏死型（CE3）包虫，囊肿最大径小于8cm（包括8cm）", "label": 5, "label_text": "Multiple", "id": "s5970"}
{"text": " 如受试对象有多颗牙待拔除，只纳入其中一颗牙。", "label": 0, "label_text": "Therapy or Surgery", "id": "s5971"}
{"text": " ②术前病理证实为癌，并位于乙状结肠、直肠（距离肛缘30cm以内）；", "label": 4, "label_text": "Disease", "id": "s5972"}
{"text": "1.符合艾滋病诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s5973"}
{"text": "1.符合以上诊断标准，确诊为复杂先天性心脏病患者并行体外循环术者；", "label": 11, "label_text": "Diagnostic", "id": "s5974"}
{"text": " 7）精神异常患者。", "label": 4, "label_text": "Disease", "id": "s5975"}
{"text": " 3.发病48小时内；", "label": 4, "label_text": "Disease", "id": "s5976"}
{"text": " ②符合原发性膝关节骨关节炎诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s5977"}
{"text": " 4)合并高泌乳素血症、甲状腺功能减低者", "label": 4, "label_text": "Disease", "id": "s5978"}
{"text": "(1) 符合GDM高危人群标准;", "label": 11, "label_text": "Diagnostic", "id": "s5979"}
{"text": " 14. 怀孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s5980"}
{"text": " 4.年龄18-70岁；", "label": 3, "label_text": "Age", "id": "s5981"}
{"text": " 会阴神经障碍或严重并发症不能耐受手术", "label": 5, "label_text": "Multiple", "id": "s5982"}
{"text": "    [3]仅适合姑息治疗的表浅恶性实体肿瘤患者;", "label": 5, "label_text": "Multiple", "id": "s5983"}
{"text": "1.严重输卵管积水（直径大于3cm）、重度宫腔粘连患者、子宫畸形，先天性肾上腺皮质增生症、库欣综合征患者；", "label": 4, "label_text": "Disease", "id": "s5984"}
{"text": " （4）经头颅CT或MRI证实", "label": 11, "label_text": "Diagnostic", "id": "s5985"}
{"text": " (4) 4周内无急性加重、未改变原有治疗方案、未用抗生素和未全身性使用激素。", "label": 5, "label_text": "Multiple", "id": "s5986"}
{"text": "肝、肾功能明显异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s5987"}
{"text": " 2、正常眼压性青光眼：具有类似于POAG的视盘改变，RNFL及视野损害，24h眼压测量均≤21mmHg, 房角开放", "label": 5, "label_text": "Multiple", "id": "s5988"}
{"text": "1.近期服用预防急性高原病药物史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s5989"}
{"text": " 6.获得知情同意。", "label": 13, "label_text": "Consent", "id": "s5990"}
{"text": " 3 阴道切缘阳性", "label": 24, "label_text": "Neoplasm Status", "id": "s5991"}
{"text": " 7）主要器官功能基本正常：血红蛋白≥90g/L，血小板≥80×109/L，中性粒细胞计数≥1.5×109/L；ALT及AST≤正常上限的2.5倍，如伴肝转移，则ALT及AST≤正常上限的5倍，总胆红素≤正常上限的1.5倍；血肌酐≤正常上限的1.25倍或肌酐清除率≥45ml/min；心脏彩超提示左室射血分数≥正常值低限（50%）。", "label": 5, "label_text": "Multiple", "id": "s5992"}
{"text": "1.经病理组织学或者细胞学检查确诊的肝细胞癌；", "label": 11, "label_text": "Diagnostic", "id": "s5993"}
{"text": " 2.存在非糖尿病引起的严重心脑血管疾病，肝肾疾病患者", "label": 4, "label_text": "Disease", "id": "s5994"}
{"text": " ③病程＜1年；", "label": 4, "label_text": "Disease", "id": "s5995"}
{"text": " (2)重度非增生期糖尿病视网膜病变；", "label": 4, "label_text": "Disease", "id": "s5996"}
{"text": " 6.需要在研究期间使用系统性皮质类固醇治疗（≥5mg/d的泼尼松或等效剂量的其他皮质类固醇）或其他免疫抑制药物治疗的受试者，包括MM的治疗，用于治疗不良事件的除外；", "label": 5, "label_text": "Multiple", "id": "s5997"}
{"text": " (11) 合并有心、脑血管、肝、肾和造血系统等严重疾病者；", "label": 4, "label_text": "Disease", "id": "s5998"}
{"text": " 2) 病理证实为胸腺肿瘤", "label": 11, "label_text": "Diagnostic", "id": "s5999"}
{"text": " ③妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6000"}
{"text": " 5.具有呼吸功能不全、上呼吸道不通畅、睡眠呼吸暂停、循环不稳以及6.镇痛药物应用禁忌证者；", "label": 5, "label_text": "Multiple", "id": "s6001"}
{"text": " （7）正在参加其他临床试验或三个月内参加过其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6002"}
{"text": " 2、接受过其他有创治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6003"}
{"text": " 8)三个月内用过已知对某脏器有损害的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6004"}
{"text": " ③妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6005"}
{"text": " 2 活动性消化道出血；", "label": 4, "label_text": "Disease", "id": "s6006"}
{"text": " 5)肝功能不全，血清直接胆红素、间接胆红素、转氨酶高于正常2倍以上；血清总蛋白或白蛋白低于正常;", "label": 5, "label_text": "Multiple", "id": "s6007"}
{"text": "手术类型：择期肩关节镜手术患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6008"}
{"text": "1.SICU住院时间小于24小时者", "label": 26, "label_text": "Encounter", "id": "s6009"}
{"text": " 4)诊断为骨质疏松症，T值≤-2.5；", "label": 5, "label_text": "Multiple", "id": "s6010"}
{"text": " 不能耐受药物治疗；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6011"}
{"text": " 4.患者正在服用一些可能会影响伤口愈合的系统性药物，如肾上腺皮质激素和抗代谢药", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6012"}
{"text": " (2)体征：常见鼻黏粘膜苍白、水肿，鼻腔水样分泌物；", "label": 1, "label_text": "Sign", "id": "s6013"}
{"text": " 7. 心血管系统、呼吸系统、中枢神经系统、肝、肾、造血系统、内分泌系统功能明显异常；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6014"}
{"text": " 8.任何不稳定的或可能危及受试者安全性及其对研究的依从性的状况；研究者认为受试者存在其他任何不适宜参加研究的因素。", "label": 5, "label_text": "Multiple", "id": "s6015"}
{"text": "妊娠妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6016"}
{"text": " 4. 胃大切术后；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6017"}
{"text": " 7. 在用研究药物前3个月内参加过其它药物研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s6018"}
{"text": " ＊有经皮肺穿刺瘤体内注射禁忌症的患者；", "label": 4, "label_text": "Disease", "id": "s6019"}
{"text": " 放疗结束时间距本研究入组时≥4周；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6020"}
{"text": " 3.符合中医气阴不足证辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s6021"}
{"text": " 7.患者及家属了解本临床试验，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6022"}
{"text": " ④体力状况评分(KPS)70分以上。", "label": 9, "label_text": "Risk Assessment", "id": "s6023"}
{"text": " 7）严重营养不良者", "label": 1, "label_text": "Sign", "id": "s6024"}
{"text": "2.1  具有影响口服药物的多种因素（比如不能吞咽、胃肠道切除术后、慢性腹泻等）；", "label": 5, "label_text": "Multiple", "id": "s6025"}
{"text": " 11. 研究者认为受试者有潜在风险或有干扰受试者的任何其他因素", "label": 21, "label_text": "Researcher Decision", "id": "s6026"}
{"text": " ③患者对躯体症状引起关注，或造成痛苦，或社会功能受到影响，三者居其一。", "label": 1, "label_text": "Sign", "id": "s6027"}
{"text": " （3）妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6028"}
{"text": " （5）6MWD基线150-550m；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6029"}
{"text": " （4）年龄：40岁≤年龄≤65岁；", "label": 3, "label_text": "Age", "id": "s6030"}
{"text": "(i)患者有多器官衰竭，肾脏替代治疗，慢性肾损伤4期或5期，低容量休克；", "label": 5, "label_text": "Multiple", "id": "s6031"}
{"text": " (2)合并严重心脏、脑部血管、肝肾及凝血系统重大基础疾病者；", "label": 4, "label_text": "Disease", "id": "s6032"}
{"text": " 10.具有精神类药物滥用史且无法戒除者或有精神障碍的患者；", "label": 5, "label_text": "Multiple", "id": "s6033"}
{"text": " 10. 研究医师认为有任何不适合入选的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s6034"}
{"text": " (4)存在慢性鼻炎、扁桃体肥大等上气道疾病", "label": 4, "label_text": "Disease", "id": "s6035"}
{"text": " 5）从胸痛发作到诊断为急性心肌梗死超过 24小时的患者", "label": 4, "label_text": "Disease", "id": "s6036"}
{"text": "（1）组织病理学证实（患者入组所在研究中心）为肺癌（包括小细胞肺癌和非小细胞肺癌患者均可）。", "label": 11, "label_text": "Diagnostic", "id": "s6037"}
{"text": " 3 已接受TACE术或其它抗肿瘤治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6038"}
{"text": " 9.怀孕", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6039"}
{"text": " ⑤合并患有心、脑、肝和造血系统等系统性疾病，或影响其生存的其它严重疾病；", "label": 4, "label_text": "Disease", "id": "s6040"}
{"text": "1.符合美国耳鼻咽喉头颈外科学会（AAO-HNSF）2017年[14]发表的关于BPPV诊治的临床诊疗指南，明确诊断为单侧BPPV（单侧后半规管BPPV或水平半规管BPPV）；", "label": 11, "label_text": "Diagnostic", "id": "s6041"}
{"text": " b. 患者既往有其它肿瘤病史，除非是原位宫颈癌，治疗过的鳞癌或膀胱上皮肿瘤（Ta和TIS），或其它已经接受根治性治疗的恶性肿瘤（至少在入组前5年以上）。", "label": 5, "label_text": "Multiple", "id": "s6042"}
{"text": "1）怀孕或哺乳期女性", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6043"}
{"text": "1．孕妇或哺乳期妇女,或未采取避孕措施的育龄妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6044"}
{"text": " 3.初诊初治的PMR患者，未使用过激素治疗", "label": 5, "label_text": "Multiple", "id": "s6045"}
{"text": " ⑧导电凝胶或超声耦合剂过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s6046"}
{"text": " 3、年龄大于18岁", "label": 3, "label_text": "Age", "id": "s6047"}
{"text": " 8）预计生存期﹤3个月者；", "label": 23, "label_text": "Life Expectancy", "id": "s6048"}
{"text": " 2）术前血清HBsAg（+）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6049"}
{"text": " (9)治疗时间少于28天者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6050"}
{"text": " 11. 任何不稳定的系统性疾病：包括活动性感染、未得到控制的高血压，不稳定型心绞痛，最近3个月内开始发作的心绞痛，充血性心功能衰竭（纽约心脏病协会[NYHA]≥II级），入组前6个月内发生的心肌梗死，需要药物治疗的严重心律失常，肝脏、肾脏或代谢性疾病；", "label": 4, "label_text": "Disease", "id": "s6051"}
{"text": " 4）植入起搏器或ICD；", "label": 34, "label_text": "Device", "id": "s6052"}
{"text": " 9）受试者自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6053"}
{"text": " 8.严重的未控制的反复感染者，或其它严重的未控制的伴随疾病；", "label": 4, "label_text": "Disease", "id": "s6054"}
{"text": " （3）睡眠严重程度量表（Insomnia Severity Index, ISI）评分≥11分；", "label": 9, "label_text": "Risk Assessment", "id": "s6055"}
{"text": " 3.符合入选标准1、2的既往干预且随访资料完整者。", "label": 22, "label_text": "Data Accessible", "id": "s6056"}
{"text": " 5.患者肿瘤组织无EGFR酪氨酸激酶抑制剂敏感性突变和ALK基因重排或不明；", "label": 5, "label_text": "Multiple", "id": "s6057"}
{"text": " 2.出血累及小脑；", "label": 1, "label_text": "Sign", "id": "s6058"}
{"text": " 14、器官移植受者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6059"}
{"text": " 4. 医生认为不适合纳入者。", "label": 21, "label_text": "Researcher Decision", "id": "s6060"}
{"text": " （5）自愿加入本研究，能接受问卷调查并配合胃电图、HRV等试验、检查。", "label": 5, "label_text": "Multiple", "id": "s6061"}
{"text": "- 参照美国类风湿病学会(American College of Rheumatology，ACR)1995年制定的膝关节骨关节炎诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6062"}
{"text": " 2）患者缺乏依从性。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6063"}
{"text": " （4）曾接受过放疗或与本次试验所用诱导化疗方案不一致的化疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6064"}
{"text": " 4.有腹部手术史者（如胆囊切除术等）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6065"}
{"text": "母亲：20-35岁，单胎足月分娩，预计哺乳时间超过2个月", "label": 5, "label_text": "Multiple", "id": "s6066"}
{"text": " 6、急性发热性疾病者及传染病者", "label": 4, "label_text": "Disease", "id": "s6067"}
{"text": " (3)子宫内膜异位症者", "label": 4, "label_text": "Disease", "id": "s6068"}
{"text": " 5.伴有与ASD无关的严重心肌疾患或瓣膜疾病。", "label": 4, "label_text": "Disease", "id": "s6069"}
{"text": " ⑥ 有异常性器官出血而未经确诊者；", "label": 1, "label_text": "Sign", "id": "s6070"}
{"text": " [3]COPD急性加重期患者；", "label": 4, "label_text": "Disease", "id": "s6071"}
{"text": " 2.对已知微量元素过敏或不良反应的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s6072"}
{"text": " 任何病史，据研究者判断可能干扰试验结果或增加患者风险；", "label": 21, "label_text": "Researcher Decision", "id": "s6073"}
{"text": " 4.意识清楚，能合作", "label": 17, "label_text": "Capacity", "id": "s6074"}
{"text": " (5)、年龄在35-75岁之间；", "label": 3, "label_text": "Age", "id": "s6075"}
{"text": " 3）依从性差者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6076"}
{"text": "①既往或合并其他恶性肿瘤病史，但已治愈的皮肤基底细胞癌和宫颈原位癌除外。", "label": 4, "label_text": "Disease", "id": "s6077"}
{"text": "1.入选前已在使用抗凝药物者，如平时在服用华法林、阿司匹林、玻立维或新型口服抗凝剂者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6078"}
{"text": " 2.ECOG评分：0-2分", "label": 9, "label_text": "Risk Assessment", "id": "s6079"}
{"text": " 2）任何临床相关基础疾病的证据（呼吸、消化、心血管、内分泌、血液、泌尿等各系统基础疾病）", "label": 4, "label_text": "Disease", "id": "s6080"}
{"text": " 6. 知情同意。", "label": 13, "label_text": "Consent", "id": "s6081"}
{"text": " 16.在研究者的判定下，不可能遵守方案的受试者、存在可能影响有效性或安全性的严重生理或心理疾病的患者；", "label": 5, "label_text": "Multiple", "id": "s6082"}
{"text": " 6.口内有固定矫治器的患者；", "label": 34, "label_text": "Device", "id": "s6083"}
{"text": " 2  AJCC第8版分期为II-Ⅳa期（除N3）；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6084"}
{"text": " (14) 任何无法控制的临床问题(如严重的精神、神经、心血管、呼吸等系统疾病)；", "label": 4, "label_text": "Disease", "id": "s6085"}
{"text": "1、性别：男性或女性，健康志愿者；", "label": 5, "label_text": "Multiple", "id": "s6086"}
{"text": " 4)同意参加本研究，并签署知情同意书.", "label": 13, "label_text": "Consent", "id": "s6087"}
{"text": " 9）能够理解试验的目的，自愿参加并签署知情同意书的患者。", "label": 13, "label_text": "Consent", "id": "s6088"}
{"text": " 5.知情同意参加本研究，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6089"}
{"text": " （4）其他继发性失眠者，或躯体疾病引发失眠者（如脑卒中后、帕金森病等）；", "label": 4, "label_text": "Disease", "id": "s6090"}
{"text": " 16、在签署知情同意书之前4周内曾参加任何临床试验者；", "label": 5, "label_text": "Multiple", "id": "s6091"}
{"text": " 6)签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6092"}
{"text": "1. 在我院行持续性非卧床腹膜透析的终末期肾病患者；", "label": 5, "label_text": "Multiple", "id": "s6093"}
{"text": " 2.年龄18-70周岁，女性；", "label": 5, "label_text": "Multiple", "id": "s6094"}
{"text": " (14) 对试验药物有过敏史或不能耐受的病人。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6095"}
{"text": " 4.年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s6096"}
{"text": " 26. 随机前使用过VEGFR等相关靶点抑制剂的；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6097"}
{"text": " （5）合并肾功能不全，需要透析治疗；", "label": 5, "label_text": "Multiple", "id": "s6098"}
{"text": " （8）严重的精神障碍患者；", "label": 4, "label_text": "Disease", "id": "s6099"}
{"text": " ②知情同意，自愿参加。", "label": 13, "label_text": "Consent", "id": "s6100"}
{"text": " ③签署知情同意书，同意入组研究的患者", "label": 13, "label_text": "Consent", "id": "s6101"}
{"text": " 3.自愿签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6102"}
{"text": " 2.中医辨证为大肠湿热型;", "label": 11, "label_text": "Diagnostic", "id": "s6103"}
{"text": " 4.化疗前血常规及肝肾功能正常。", "label": 5, "label_text": "Multiple", "id": "s6104"}
{"text": " 6) 慢性肾功能衰竭", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6105"}
{"text": " 3. 双肾积液无法通过放置输尿管支架或肾造瘘缓解；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6106"}
{"text": " 4.糖化血红蛋白在6.3%至10%之间；空腹血糖小于11.1mmol/L", "label": 12, "label_text": "Laboratory Examinations", "id": "s6107"}
{"text": "1.0-3岁儿童的儿童家长；", "label": 3, "label_text": "Age", "id": "s6108"}
{"text": " 2.符合美国精神障碍诊断与统计手册第4版（DSM-IV）中抑郁症的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6109"}
{"text": " 3）既往曾有酒药依赖及急性中毒史的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s6110"}
{"text": " (3)合并全身或局部恶性肿瘤", "label": 4, "label_text": "Disease", "id": "s6111"}
{"text": " 3. 需要进入儿童重症监护室治疗的患儿。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6112"}
{"text": "（1）非哮喘患者及哮喘患者处于稳定期的患者。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6113"}
{"text": " 9. 预期寿命&lt;13个月", "label": 23, "label_text": "Life Expectancy", "id": "s6114"}
{"text": " 9)对所用试验药物过敏的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6115"}
{"text": " 4. 所有病人本次诊疗前未行化疗、放疗及其它特殊治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6116"}
{"text": " 6) Ⅱ、Ⅲ度房室传导阻滞；", "label": 4, "label_text": "Disease", "id": "s6117"}
{"text": "1、肝、肾功能损伤者", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6118"}
{"text": " 2.20-26岁青少年。", "label": 3, "label_text": "Age", "id": "s6119"}
{"text": "(1)有严重的心肺疾病或其他内科疾病，慢性肾脏疾病", "label": 4, "label_text": "Disease", "id": "s6120"}
{"text": " (8)静息心率&lt;50次/min", "label": 12, "label_text": "Laboratory Examinations", "id": "s6121"}
{"text": "1、符合原发性痛风诊断标准并处于间歇期者；", "label": 11, "label_text": "Diagnostic", "id": "s6122"}
{"text": "（1）创伤部位严重感染者；", "label": 4, "label_text": "Disease", "id": "s6123"}
{"text": "1.年龄≥18岁；", "label": 3, "label_text": "Age", "id": "s6124"}
{"text": "1 年龄≥65岁，&lt;90岁；", "label": 3, "label_text": "Age", "id": "s6125"}
{"text": " （4）适应症：", "label": 4, "label_text": "Disease", "id": "s6126"}
{"text": " 16. 预期生存时间&lt;1年。", "label": 23, "label_text": "Life Expectancy", "id": "s6127"}
{"text": " 7）肺功能不全：第一秒用力呼气量＜1.0L，PaO2＜60mmHg，PaCO2＞50mmHg;", "label": 5, "label_text": "Multiple", "id": "s6128"}
{"text": " 13)精神病的现状或病史，会影响到遵守研究协议或给予知情同意的情况。酒精或药物滥用的历史，影响到遵守研究协议的情况。", "label": 2, "label_text": "Addictive Behavior", "id": "s6129"}
{"text": " 2.服用降糖药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6130"}
{"text": " 4、严重心、肝、肾功能不全，或严重精神疾患，或研究人员认为不适合参加本研究。", "label": 5, "label_text": "Multiple", "id": "s6131"}
{"text": " 6、对研究药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6132"}
{"text": " 2、原发性/转移性肝癌；其他恶性肿瘤患者（不包括已治愈者）", "label": 4, "label_text": "Disease", "id": "s6133"}
{"text": " ④生命体征平稳，无意识障碍。", "label": 1, "label_text": "Sign", "id": "s6134"}
{"text": " 9. FS-LASIK术后1周，fBUT≤5s/ SchirmerⅠ（无表面麻醉）≤5mm/5min，且角膜染色（+），且有干眼主诉症状。", "label": 5, "label_text": "Multiple", "id": "s6135"}
{"text": " 15.有任何其他具有临床意义的疾病史或证据（以上列出的除外），且会对受试者安全性造成风险或干扰研究评价、程序或完成", "label": 5, "label_text": "Multiple", "id": "s6136"}
{"text": " (5）签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6137"}
{"text": " 9、上消化道梗阻或生理功能异常或患吸收不良综合征，可能影响卡培他滨/S-1吸收者。", "label": 5, "label_text": "Multiple", "id": "s6138"}
{"text": " （8）患者不能够配合疗效及不良反应的观察。", "label": 17, "label_text": "Capacity", "id": "s6139"}
{"text": " ⑤术前未发现有远处转移病灶；", "label": 24, "label_text": "Neoplasm Status", "id": "s6140"}
{"text": " （3）伴有糖尿病、冠心病、肝硬化、消化性溃疡、哮喘、慢阻肺、地中海贫血、慢性肾功能不全等基础疾病者，以及6-磷酸葡萄糖脱氢酶（G-6-PD）缺乏病史者；", "label": 4, "label_text": "Disease", "id": "s6141"}
{"text": " 8. 严重的免疫功能缺陷者", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6142"}
{"text": " 3)纽约心脏病协会心功能分级为II、III、IV级的心力衰竭。", "label": 5, "label_text": "Multiple", "id": "s6143"}
{"text": " (8)非烟酒嗜好者；", "label": 2, "label_text": "Addictive Behavior", "id": "s6144"}
{"text": " 4）PEF ≤ 预测值的70%。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6145"}
{"text": "1排除其他内分泌障碍", "label": 4, "label_text": "Disease", "id": "s6146"}
{"text": " 3.在过去的5年内有药物滥用史及酒精依赖史。", "label": 2, "label_text": "Addictive Behavior", "id": "s6147"}
{"text": " BMI ≥ 25且 ≤ 40 kg/m^2;", "label": 9, "label_text": "Risk Assessment", "id": "s6148"}
{"text": " (1) 病理学确诊的I-IV期非小细胞肺癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s6149"}
{"text": " 4）活动性乙型肝炎或丙型肝炎病毒感染者；", "label": 4, "label_text": "Disease", "id": "s6150"}
{"text": " 7.既往对同类药物不耐受或过敏史", "label": 7, "label_text": "Allergy Intolerance", "id": "s6151"}
{"text": " 3) 在过去五年内有药物滥用史或试验前3个月使用过毒品者。", "label": 2, "label_text": "Addictive Behavior", "id": "s6152"}
{"text": " 5、知情同意，志愿受试", "label": 13, "label_text": "Consent", "id": "s6153"}
{"text": "(1) ASA I-II级", "label": 9, "label_text": "Risk Assessment", "id": "s6154"}
{"text": " 4.  有远处淋巴结转移，不能行区域淋巴结清扫者", "label": 5, "label_text": "Multiple", "id": "s6155"}
{"text": " 3）接受其他化疗方案（非卡培他滨单药/联合奥沙利铂化疗）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6156"}
{"text": " （2）稀发排卵诊断依据", "label": 11, "label_text": "Diagnostic", "id": "s6157"}
{"text": "1、确诊的基底节区自发性脑出血患者（符合美国成人自发性脑出血治疗指南（2010）的诊断标准）；", "label": 11, "label_text": "Diagnostic", "id": "s6158"}
{"text": " 4)肝肾功能严重异常者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6159"}
{"text": " （2）严格符合《原发性肝癌诊疗规范》（2017年版）临床诊断标准或经病理组织学或者细胞学检查确诊的复发/转移的不可切除的HCC患者，并且无法接受姑息性手术或放射治疗，且至少有一个可测量病灶（根据mRECIST 1.1版要求该可测量病灶螺旋CT扫描长径≥10mm或肿大淋巴结短径≥15mm）；确认肝癌后未做任何包括肝移植、外科切除、TACE、射频/微波/化学消融、氩氦刀、超声刀、放疗等治疗；", "label": 5, "label_text": "Multiple", "id": "s6160"}
{"text": "（1）造口患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6161"}
{"text": " （3）6月内月经至少≥1次。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6162"}
{"text": " 6、应首次发病或过去发病未留有肢体瘫痪等后遗症的再次发病者，且不影响本次NIHSS评分，既往发病者本次入院mRS评分≤1分。", "label": 5, "label_text": "Multiple", "id": "s6163"}
{"text": " (5)近6个月有脑卒中事件发生；", "label": 4, "label_text": "Disease", "id": "s6164"}
{"text": " 4.可以进行连续脑氧和腹部氧和监测的新生儿", "label": 5, "label_text": "Multiple", "id": "s6165"}
{"text": " 5)所有病例无其他复合伤。", "label": 4, "label_text": "Disease", "id": "s6166"}
{"text": " ⑥有能力依从研究方案、自愿参加并签知情同意书。", "label": 5, "label_text": "Multiple", "id": "s6167"}
{"text": " 3. 最近5年有其他恶性疾病史者。", "label": 4, "label_text": "Disease", "id": "s6168"}
{"text": " (7) 精神和行为障碍不能充分知情者；", "label": 13, "label_text": "Consent", "id": "s6169"}
{"text": " 9. 过敏史/超敏反应史（包括对药物或其他物质）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6170"}
{"text": " 7.溃目不超过2个，溃疡直径不超过5mm。", "label": 4, "label_text": "Disease", "id": "s6171"}
{"text": " （2）QTcB延长（男性&gt;450ms，女性&gt;470ms）。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6172"}
{"text": " 3. 转氨酶超过正常值上限3倍，肌酐超过正常值；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6173"}
{"text": " 9、患者或其法定代理人自愿并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6174"}
{"text": " ④患者为妊娠期、患有免疫性疾病、器官移植后、患有其他器官恶性肿瘤、合并子宫和/或附件病变者；", "label": 5, "label_text": "Multiple", "id": "s6175"}
{"text": " ③从未出现过重性抑郁发作，且不符合恶劣心境的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6176"}
{"text": " （3）有特殊健康问题或依赖技术维持如呼吸机维持、营养支持等的新生儿；", "label": 5, "label_text": "Multiple", "id": "s6177"}
{"text": " 2.严重过敏体质者，尤其是细胞因子IL-2过敏患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6178"}
{"text": " 20.合并有以下CYP3A4、P-gp或Bcrp的抑制剂或诱导剂，如伊曲康唑、酮康唑或决奈达隆等。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6179"}
{"text": " 9.有全血细胞减少/血栓性疾病", "label": 4, "label_text": "Disease", "id": "s6180"}
{"text": "1.患者既往曾规律服用过治疗重度认知障碍改善认知功能的药物，如美金刚", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6181"}
{"text": " 3.同时伴发其他恶性肿瘤。", "label": 4, "label_text": "Disease", "id": "s6182"}
{"text": "(1)受试者年龄在18-60岁之间，体型适中，男女均可；", "label": 5, "label_text": "Multiple", "id": "s6183"}
{"text": " 6)手术前 5 年内有化疗史", "label": 0, "label_text": "Therapy or Surgery", "id": "s6184"}
{"text": " （16）不能进行长期随访或依从性差者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6185"}
{"text": " 2.既往有胃静脉曲张（GOV2型或IGV1型）出血史.", "label": 4, "label_text": "Disease", "id": "s6186"}
{"text": " 7、试验前4周内无呼吸道感染及全身感染，尤其是严重呼吸道感染、肺结核、真菌感染。", "label": 4, "label_text": "Disease", "id": "s6187"}
{"text": " ②符合北京儿童医院重症医学科（包括PICU和CCU）收入条件，诊断或拟诊为重症革兰阳性（G+）球菌感染；", "label": 11, "label_text": "Diagnostic", "id": "s6188"}
{"text": " 4)可疑主动脉夹层；", "label": 4, "label_text": "Disease", "id": "s6189"}
{"text": " (4)婴儿年龄&lt;14天；", "label": 3, "label_text": "Age", "id": "s6190"}
{"text": " 8、严重肝肾疾病(严重肝脏疾病是指肝硬化、门脉高压和静脉曲张的出血，严重肾脏疾病包括透析、肾移植)；", "label": 4, "label_text": "Disease", "id": "s6191"}
{"text": " 11)在首次用药前2个月内进行过大手术或受严重外伤的患者；", "label": 5, "label_text": "Multiple", "id": "s6192"}
{"text": " 5.有结肠外表现，如皮肤黏膜表现（口腔溃疡、结节性红斑和坏疽性脓皮病）、关节损害（如外周关节炎、脊柱关节炎等）、眼部病变（如虹膜炎、巩膜炎、葡萄膜炎等）、肝胆疾病（如脂肪肝、原发性硬化性胆管炎、胆石症等）、血栓栓塞性疾病者；", "label": 4, "label_text": "Disease", "id": "s6193"}
{"text": "1.鳞癌（包括腺鳞癌）、小细胞肺癌（包括小细胞癌和非小细胞混合的肺癌）；", "label": 4, "label_text": "Disease", "id": "s6194"}
{"text": " 10.存在任何严重的医疗状况，包括但不限于，不能控制的高血压、不能控制的糖尿病、不能控制的感染、活动性/有症状的心脏疾患、慢性阻塞性肺疾病（COPD）、肾功能衰竭、活动性出血、精神疾病等，可能会使患者承受巨大风险。", "label": 5, "label_text": "Multiple", "id": "s6195"}
{"text": "1.结核性脓胸", "label": 4, "label_text": "Disease", "id": "s6196"}
{"text": " (3)入组前30天内（1个月）接受其他临床试验，可能影响本研究效应指标观测者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6197"}
{"text": " 10.HIV、乙型肝炎表面抗原阳性、梅毒抗体阳性、丙肝抗体阳性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6198"}
{"text": " 9．严重肾损害肌酐清除率&lt;30ml/min;", "label": 5, "label_text": "Multiple", "id": "s6199"}
{"text": " 4. 急性胃或十二指肠溃疡；", "label": 4, "label_text": "Disease", "id": "s6200"}
{"text": " 2.年龄在50岁-65岁，男女均可。", "label": 5, "label_text": "Multiple", "id": "s6201"}
{"text": "①目前正在参加其他的临床研究。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6202"}
{"text": "年龄50-65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s6203"}
{"text": " 4.术后病检回报颈部淋巴结未转移。", "label": 11, "label_text": "Diagnostic", "id": "s6204"}
{"text": " （3）术前或术后经病理学检查，确诊为浸润性乳腺导管癌或乳腺小叶癌；", "label": 11, "label_text": "Diagnostic", "id": "s6205"}
{"text": " (1) 有意识障碍、痴呆或精神疾病史者；", "label": 4, "label_text": "Disease", "id": "s6206"}
{"text": "1）符合慢性肥厚性咽炎西医诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6207"}
{"text": " 7．使用β受体阻滞剂，包括含β受体阻滞剂的滴眼液。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6208"}
{"text": " 使用已知干扰接触镜配戴的全身性药物（例如，长期使用类固醇）。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6209"}
{"text": " 4.未控制的肝性脑病，未纠正的失血性休克；", "label": 4, "label_text": "Disease", "id": "s6210"}
{"text": " ⑦急诊手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s6211"}
{"text": " 10.近 3个月内参加其它临床研究者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6212"}
{"text": " 6.高血压患者。", "label": 4, "label_text": "Disease", "id": "s6213"}
{"text": "1 幽闭恐惧症", "label": 4, "label_text": "Disease", "id": "s6214"}
{"text": " 4.术前为窦性心律。", "label": 4, "label_text": "Disease", "id": "s6215"}
{"text": " （5）患有神经系统疾病的儿童；", "label": 4, "label_text": "Disease", "id": "s6216"}
{"text": " ④严重心脑血管系统、肝、肾、造血系统疾病以及肿瘤等患者；", "label": 4, "label_text": "Disease", "id": "s6217"}
{"text": " ⑤存在严重的糖尿病慢性并发症及严重肝肾功能不全，心功能不全的患者。", "label": 5, "label_text": "Multiple", "id": "s6218"}
{"text": " II 最后一次化疗与疾病进展间隔不足1年；", "label": 5, "label_text": "Multiple", "id": "s6219"}
{"text": " 有可能妨碍受试者完成治疗或知情同意的精神疾病。", "label": 5, "label_text": "Multiple", "id": "s6220"}
{"text": " 8、研究者综合判断不适合纳入研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s6221"}
{"text": " ⑥.对受试样品过敏或出现明显消化道症状如不能耐受者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6222"}
{"text": " ⑦妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6223"}
{"text": " 2.经病理学或组织学确诊的晚期恶性实体瘤患者（包括但不限于晚期胃癌、肺癌、肝癌、乳腺癌、宫颈癌、卵巢癌等）；", "label": 11, "label_text": "Diagnostic", "id": "s6224"}
{"text": " 2)需进行影响免疫反应的治疗如:使用皮质类固醇两周以上，或使用免疫抑制剂如烷化剂、抗代谢药,或接受放射治疗等；或在rTV疫苗接种后1个月内的密切接触者中有接受以上治疗者；", "label": 5, "label_text": "Multiple", "id": "s6225"}
{"text": " 3.精神疾病；", "label": 4, "label_text": "Disease", "id": "s6226"}
{"text": " (9)在筛选时受试者有活动性肺结核并且正在进行治疗（在试验期间出现活动性肺结核的受试者将退出治疗以便开始抗结核药治疗）", "label": 5, "label_text": "Multiple", "id": "s6227"}
{"text": " 20) 研究者、研究中心、申办方和合同研究组织的雇员或相关人员；", "label": 21, "label_text": "Researcher Decision", "id": "s6228"}
{"text": " （2）ASAI-III级", "label": 9, "label_text": "Risk Assessment", "id": "s6229"}
{"text": " 4) 对试验药有既往过敏史的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s6230"}
{"text": " 6.NIHSS于脑卒中后一星期内23分或以下；", "label": 9, "label_text": "Risk Assessment", "id": "s6231"}
{"text": " 5、主要脏器功能基本正常(骨髓、心肝肾)，白血病＞3×109/L，中性粒细胞＞1.5×109/L，血小板＞100×109/L，血红蛋白＞9.0g/dl；胆红素 正常或 &lt; 1.5 x ULN；AST (SGOT)、ALT (SGPT) &lt; 2.5 x ULN；血清肌酐&lt; 1.5 x ULN", "label": 5, "label_text": "Multiple", "id": "s6232"}
{"text": " 13）经治医生认为不适合入选者", "label": 21, "label_text": "Researcher Decision", "id": "s6233"}
{"text": " （4）同意行胃镜检查取胃黏膜活检组织标本进行HP培养及药敏试验,且培养阳性.", "label": 5, "label_text": "Multiple", "id": "s6234"}
{"text": "1、皮肤过敏者、局限有炎症或伤口", "label": 5, "label_text": "Multiple", "id": "s6235"}
{"text": " 8）如接受他汀或贝特类调脂药物的治疗，需在随机化前3个月内每日服用稳定剂量的调脂药物的情况下，血脂保持平稳（甘油三酯（TG）&lt;1.7mmol/L、总胆固醇（TC）&lt;6.00mmol/L、低密度脂蛋白胆固醇（LDL-C）&lt;4.00mmol/L）。", "label": 5, "label_text": "Multiple", "id": "s6236"}
{"text": " 2.有任何严重的并发症(如肺部感染等)或伴随疾病者(如未能控制的糖尿病等)；", "label": 4, "label_text": "Disease", "id": "s6237"}
{"text": " 4. 责任事件与闭塞血管相关（责任事件包括卒中、TIA）；", "label": 4, "label_text": "Disease", "id": "s6238"}
{"text": " 3、无眼部异常（尤其无眼睑功能异常）、无眼部手术史、无上睑下垂家族史、无影响眼睑功能的全身性疾病或用药史；", "label": 5, "label_text": "Multiple", "id": "s6239"}
{"text": "1）经简明国际神经精神障碍访谈-中文版6.0.0结构化会晤检查，符合美国精神医学学会编著的精神障碍诊断与统计手册第5版（DSM-V）重性抑郁障碍诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6240"}
{"text": " ③不能耐受本研究药物治疗者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6241"}
{"text": " 7、孕妇及哺乳期；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6242"}
{"text": " 4、近6个月洁牙。", "label": 30, "label_text": "Oral related", "id": "s6243"}
{"text": " （6）在需要治疗区域有除特应性皮炎以外其它皮肤病的患儿。", "label": 4, "label_text": "Disease", "id": "s6244"}
{"text": " 9）在服用研究药物前24小时内服用过任何含酒精的制品；", "label": 39, "label_text": "Alcohol Consumer", "id": "s6245"}
{"text": "1.为减轻临床症状行细针吸引术的囊性结节；", "label": 5, "label_text": "Multiple", "id": "s6246"}
{"text": " 3. 食管癌根治术后淋巴结阳性患者。", "label": 5, "label_text": "Multiple", "id": "s6247"}
{"text": " （5）GRACE 评分&lt;140 分的中、低危患者；", "label": 9, "label_text": "Risk Assessment", "id": "s6248"}
{"text": "1）有眼外伤及手术史者；", "label": 5, "label_text": "Multiple", "id": "s6249"}
{"text": " 3. 入组后术中出现严重并发症，经手术医生及麻醉医师诊断需在术后转送外科ICU患者", "label": 5, "label_text": "Multiple", "id": "s6250"}
{"text": " 5.肝肾功能、凝血功能异常2倍以上；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6251"}
{"text": "1.患者有严重精神疾患、认知障碍和癫痫病史", "label": 4, "label_text": "Disease", "id": "s6252"}
{"text": " 4）使用精神类药物或严重酗酒者", "label": 5, "label_text": "Multiple", "id": "s6253"}
{"text": " ③穿刺部位皮肤感染", "label": 4, "label_text": "Disease", "id": "s6254"}
{"text": " 3）签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6255"}
{"text": " （3）出现中枢神经系统感染表现48小时以内。", "label": 4, "label_text": "Disease", "id": "s6256"}
{"text": " (14).需要在研究期间服用延长QTc间期药物治疗病症的受试者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6257"}
{"text": " 17. 无法或不愿遵守研究方案的要求者；", "label": 13, "label_text": "Consent", "id": "s6258"}
{"text": " 3.糖化血红蛋白：7-12%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6259"}
{"text": "（1）患者拒绝参与本研究；", "label": 13, "label_text": "Consent", "id": "s6260"}
{"text": "   11）恶性肿瘤及终末期疾病的患者。", "label": 4, "label_text": "Disease", "id": "s6261"}
{"text": " （3）性别：男女不限，非孕期妇女；", "label": 5, "label_text": "Multiple", "id": "s6262"}
{"text": " 3. 医生认为不适合纳入者；", "label": 21, "label_text": "Researcher Decision", "id": "s6263"}
{"text": " 3.其他有严重未控制的心肺功能不全，骨髓造血功能、凝血功能障碍、肝功能、肾功能不全、心脑血管疾病，等相应的手术禁忌症患者；", "label": 5, "label_text": "Multiple", "id": "s6264"}
{"text": "不适于进行血管介入手术治疗（PTA）的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6265"}
{"text": " (2)合并有严重感染者；", "label": 4, "label_text": "Disease", "id": "s6266"}
{"text": "复发APL；", "label": 4, "label_text": "Disease", "id": "s6267"}
{"text": " ③来我院就诊前未接受过系统治疗并愿意接受治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6268"}
{"text": " (2)异位妊娠。我们将异位妊娠定义为任何可疑包块或者大量盆腔游离液体，并不伴有宫内妊娠。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6269"}
{"text": " 6.能够理解和愿意按照研究方案接受治疗，能按要求复诊。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6270"}
{"text": " 21)乙肝表面抗原、丙型肝炎病毒抗体、人免疫缺陷病毒抗体抗原测定、梅毒螺旋体抗体试验有临床意义异常者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6271"}
{"text": " ⑸ 癫痫和其它中枢神经系统功能紊乱者；", "label": 4, "label_text": "Disease", "id": "s6272"}
{"text": " 重复测量分析纳入标准：纳入1989-2011年至少参加一次调查，年满18周岁的成年人，不处于怀孕、哺乳期，无肢体残疾，且基线协变量信息完整，至少有一次膳食数据完整且摄入量为非异常，相关结局指标变量（在研究1和2中分别对应BMI和血压）不完全缺失的研究对象。", "label": 5, "label_text": "Multiple", "id": "s6273"}
{"text": " 患者自愿加入临床试验", "label": 13, "label_text": "Consent", "id": "s6274"}
{"text": " （6）患者知情，并同意签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6275"}
{"text": " 2）符合美国精神疾病诊断和统计手册第IV版（DSM-IV）重性抑郁障碍诊断标准（通过MINI问卷证实诊断），首发或复发均可，不伴有精神病性症状；", "label": 5, "label_text": "Multiple", "id": "s6276"}
{"text": " （3）高磷血症（血清磷＞1.62mmol/L），高钙血症（血清钙＞2.70mmol/L），高尿钙症（24h尿钙＞7.5mmol），AST、ALT超过正常值上限1.5倍；eGFR＜60ml/min者。", "label": 5, "label_text": "Multiple", "id": "s6277"}
{"text": "（1)年龄18-70岁的女性患者", "label": 5, "label_text": "Multiple", "id": "s6278"}
{"text": " 6.麻醉穿侧部位局部皮肤感染、出血等。", "label": 5, "label_text": "Multiple", "id": "s6279"}
{"text": " 5）生活方式相关的失眠患者", "label": 4, "label_text": "Disease", "id": "s6280"}
{"text": " 4.自愿参加并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6281"}
{"text": " 2.病因为酒精性、激素性外伤性股骨头坏死。", "label": 4, "label_text": "Disease", "id": "s6282"}
{"text": "（1）出血量大的骨科手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6283"}
{"text": "（1）重度持续期、急性发作期、需要口服糖皮质激素进行治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s6284"}
{"text": " (4)久病体弱、严重神经官能症、痴呆、重度骨质疏松、妊娠者；", "label": 5, "label_text": "Multiple", "id": "s6285"}
{"text": "符合I期及I期以上肝性脑病诊断的患者", "label": 11, "label_text": "Diagnostic", "id": "s6286"}
{"text": " (2)眼部活动性炎症；", "label": 4, "label_text": "Disease", "id": "s6287"}
{"text": "(1)接受活體肝臟捐贈手術之成年人", "label": 0, "label_text": "Therapy or Surgery", "id": "s6288"}
{"text": " 2)已停放疗、化疗1个月以上(包括核素治疗)。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6289"}
{"text": " ?入院前大剂量服用皮质醇类激素（&gt;200mg/d）或服用免疫抑制剂", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6290"}
{"text": " 9. 肌酐&gt;2.5mg/dl（221.0umol/L）或ALT / AST&gt;3倍正常量或胆红素&gt;2.0 mg/dl（34.2umol/L）者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6291"}
{"text": "正常人，或符合糖尿病诊断标准的患者，或符合慢性肾病诊断标准的患者，或符合脑卒中诊断标准的患者，或符合冠心病诊断标准的患者；", "label": 5, "label_text": "Multiple", "id": "s6292"}
{"text": " j. 任何对患者的安全或依从性有影响的不确定因素。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6293"}
{"text": " 6.胸部CT无急性炎症感染证据；", "label": 4, "label_text": "Disease", "id": "s6294"}
{"text": " 5、充血性心衰、肝实质受损（ALT或AST&gt;正常值2倍）、Child C级的肝硬化、严重的肾功能衰竭、呼吸衰竭；", "label": 5, "label_text": "Multiple", "id": "s6295"}
{"text": " （3）存在抗栓药物应用的禁忌症；", "label": 4, "label_text": "Disease", "id": "s6296"}
{"text": "1）本研究开始前4周内曾参加过其他临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6297"}
{"text": " 2.ASA分级I-II", "label": 9, "label_text": "Risk Assessment", "id": "s6298"}
{"text": "   2、孕妇、精神异常者；", "label": 5, "label_text": "Multiple", "id": "s6299"}
{"text": " 6. 自愿参加本试验并由本人或法定授权代表签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6300"}
{"text": " 14、有消化内镜检查和治疗禁忌症；", "label": 4, "label_text": "Disease", "id": "s6301"}
{"text": "1) 40岁≤年龄≤65岁", "label": 3, "label_text": "Age", "id": "s6302"}
{"text": "（1）签署了知情同意书；", "label": 13, "label_text": "Consent", "id": "s6303"}
{"text": " 3）术后实际机械通气时间累计 ≤ 24小时；", "label": 38, "label_text": "Nursing", "id": "s6304"}
{"text": " ⑤吸入氧浓度≥60%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6305"}
{"text": "1.符合西医社区获得性肺炎诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s6306"}
{"text": " 3. 自愿参加针刺治疗并能配合各项检查者；", "label": 5, "label_text": "Multiple", "id": "s6307"}
{"text": " 3.2个月之内行CABG或PCI血运重建术", "label": 0, "label_text": "Therapy or Surgery", "id": "s6308"}
{"text": " 7.急诊手术患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6309"}
{"text": " 2、病毒性肝炎病史；", "label": 4, "label_text": "Disease", "id": "s6310"}
{"text": " 不能耐受阿司匹林和/或氢氯吡格雷或有中性白细胞减少或者血小板减少的病史或者严重肝功能不全禁用氯吡格雷的受试者；", "label": 5, "label_text": "Multiple", "id": "s6311"}
{"text": " 2)患者类风湿关节炎活动，有至少一个膝关节肿胀或疼痛，且血沉大于20mm/hr,或者C反应蛋白大于0.8mg/dl；", "label": 5, "label_text": "Multiple", "id": "s6312"}
{"text": " 8.妊娠、哺乳或有意妊娠，或判断为未使用足够的避孕措施（足够的避孕措施是指宫内节育器、口服避孕药及阻碍措施）。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6313"}
{"text": " 6 妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6314"}
{"text": " 10)孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6315"}
{"text": " 2．经病理组织学确诊的头颈部癌患者；", "label": 4, "label_text": "Disease", "id": "s6316"}
{"text": " 2.依据2008版WHO指南明确诊断的老年急性髓系白血病患者，即年龄≥65岁；", "label": 5, "label_text": "Multiple", "id": "s6317"}
{"text": "1)年龄65~75 岁；", "label": 3, "label_text": "Age", "id": "s6318"}
{"text": " 9.在拟进行CT增强扫描前72小时-7天内接受其他X线造影剂检查的患者。", "label": 11, "label_text": "Diagnostic", "id": "s6319"}
{"text": " （5）患者未有使用前列腺类药物禁忌；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6320"}
{"text": " 13. 在心脏血管外任何部位植入过支架的患者。", "label": 34, "label_text": "Device", "id": "s6321"}
{"text": " 2.有严重心血管、肺、肾、肝和消化道疾病史者；", "label": 4, "label_text": "Disease", "id": "s6322"}
{"text": " 15.研究者判断其他可能影响临床研究进行及研究结果判定的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s6323"}
{"text": " ⑥返流误吸高风险患者。", "label": 1, "label_text": "Sign", "id": "s6324"}
{"text": " 13)因其他原因导致不能接受或耐受手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6325"}
{"text": " 2.系初诊患者，未接受过其他化疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6326"}
{"text": "1、中度慢阻肺、明显心衰、阻塞性睡眠呼吸暂停综合症；", "label": 4, "label_text": "Disease", "id": "s6327"}
{"text": " 9. 对盐酸右美托咪定成分或者组分过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6328"}
{"text": "（1）呼吸状态不稳定，需大幅度调整呼吸机参数（PEEP&gt;=12cmH2O,FiO2调整幅度&gt;5%）；", "label": 5, "label_text": "Multiple", "id": "s6329"}
{"text": " 3.绝对中性粒细胞（分叶核和带状核）计数≥1.5×109/L，血小板≥100×109/L，血红蛋白≥9g/dL；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6330"}
{"text": " 2. 入住ICU超过24小时；", "label": 26, "label_text": "Encounter", "id": "s6331"}
{"text": " 急慢性疼痛患者；", "label": 4, "label_text": "Disease", "id": "s6332"}
{"text": "①同意参加本临床试验并签署书面知情同意书；", "label": 13, "label_text": "Consent", "id": "s6333"}
{"text": " (4)1周内应用阿司匹林、氯吡格雷以及活血化瘀等影响凝血功能药物者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6334"}
{"text": " 2，无法配合检查者的患者", "label": 8, "label_text": "Compliance with Protocol", "id": "s6335"}
{"text": " ②首次偏头痛发作的年龄≤50岁；", "label": 5, "label_text": "Multiple", "id": "s6336"}
{"text": "  （4）参与前知情同意，并且签署书面的同意书", "label": 13, "label_text": "Consent", "id": "s6337"}
{"text": "   3）ST段抬高型心肌梗死", "label": 4, "label_text": "Disease", "id": "s6338"}
{"text": " 4、肝脏疾病或肝功能受损", "label": 5, "label_text": "Multiple", "id": "s6339"}
{"text": " 3、术前影像学检查：肝脏增强CT或增强MR，或超声造影，或普美显提示HCC患者，并且肿瘤直径5-10cm；", "label": 5, "label_text": "Multiple", "id": "s6340"}
{"text": " 4）严重肝，肾，心血管疾病患者，或心理障碍；", "label": 4, "label_text": "Disease", "id": "s6341"}
{"text": " 8. 育龄妇女必须在入组前7天内进行妊娠试验（血清或尿液），且结果为阴性，并且愿意在试验期间和末次给予试验药物后8周采用适当的方法避孕。对于男性，应为手术绝育，或同意在试验期间和末次给予试验药物后8周采用适当的方法避孕；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6342"}
{"text": " 3．严重认知（MMSE评分＜25分＝及交流障碍而不能进行训练者", "label": 5, "label_text": "Multiple", "id": "s6343"}
{"text": " 2)有严重药物过敏反应史，尤其是皮肤反应，如皮肤粘膜眼综合征（Stevens-Johnson综合征）、中毒性表皮坏死松解症，多形性红斑等，或已知对磺胺类药物超敏者；", "label": 5, "label_text": "Multiple", "id": "s6344"}
{"text": "严重心律失常：Ⅱ度Ⅱ型或Ⅲ度房室传导阻滞，室性心动过速，病态窦房结综合征，频发室上速；（经心脏起搏治疗者除外）", "label": 5, "label_text": "Multiple", "id": "s6345"}
{"text": " 6、合并食管癌之外的其他恶性肿瘤；但是已治愈的皮肤基底细胞癌和宫颈原位癌除外；", "label": 4, "label_text": "Disease", "id": "s6346"}
{"text": "1、妊娠或哺乳期妇女,或计划妊娠者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6347"}
{"text": " （2）发病时间&gt;3个月，≤12个月；", "label": 4, "label_text": "Disease", "id": "s6348"}
{"text": " 3.除外近期感染、创伤、风湿活动等、有明显肝肾功能不全和合并恶性肿瘤、甲状腺疾患、结核或服用激素等患者；", "label": 5, "label_text": "Multiple", "id": "s6349"}
{"text": " 4) 签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6350"}
{"text": " 排除其他睡眠障碍疾病的患者儿童；", "label": 4, "label_text": "Disease", "id": "s6351"}
{"text": " 10. 患者在入组前4周内参加过其他药物临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6352"}
{"text": " 3.不适合参加该随访的任何其他情况（如妊娠等）；", "label": 21, "label_text": "Researcher Decision", "id": "s6353"}
{"text": " (2)年龄18-65岁全麻择期手术患者；", "label": 5, "label_text": "Multiple", "id": "s6354"}
{"text": " ⑦ 首次诊断，初始治疗者；", "label": 5, "label_text": "Multiple", "id": "s6355"}
{"text": " （5）简易智能精神状态检查量表（MMSE）术前检查&lt;24分", "label": 9, "label_text": "Risk Assessment", "id": "s6356"}
{"text": " ③ 1岁≤年龄≤16岁，男女不限；", "label": 5, "label_text": "Multiple", "id": "s6357"}
{"text": " （6）入选前就有心、肝、肾功能损害的患者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6358"}
{"text": " （9）正在从事其它疼痛类疾病药物或者物理治疗者，或正在参加其它临床试验者。", "label": 5, "label_text": "Multiple", "id": "s6359"}
{"text": " 4、MGS-GCS评分小于 3级以下；", "label": 9, "label_text": "Risk Assessment", "id": "s6360"}
{"text": " 6. 妊娠及哺乳期妇女;", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6361"}
{"text": " （2）颈、胸椎X线检查有颈、胸椎退行性变或脊椎关节突错位征象,无骨折,结核,肿瘤,骨质疏松, 骨质增生、椎间孔有骨刺、骨桥、炎症、腰椎间盘突出等改变；", "label": 5, "label_text": "Multiple", "id": "s6362"}
{"text": "（1）受者年龄 18-55岁，男女性别不限；要求实施亲体肾移植，供、受者经术前检查及相关程序符合医学、伦理及法律要求，准备实施亲体肾移植；", "label": 5, "label_text": "Multiple", "id": "s6363"}
{"text": " 2)肝脏：血清胆红素＞正常值上限1.5倍；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6364"}
{"text": " 5.筛选试验呈阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6365"}
{"text": "1.每个月因重度偏头痛发作无法工作的天数超过4天者；", "label": 4, "label_text": "Disease", "id": "s6366"}
{"text": " 4. 受试者或其监护人需签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6367"}
{"text": " 2）挥发性硫化物浓度（Halimeter?检测值）≥150ppb；", "label": 5, "label_text": "Multiple", "id": "s6368"}
{"text": " 7、必须至少存在一个可测量病灶（根据RECIST1.1版）；", "label": 4, "label_text": "Disease", "id": "s6369"}
{"text": " （4）年龄在20～75岁之间；", "label": 3, "label_text": "Age", "id": "s6370"}
{"text": " (2) 发热和/或皮疹症状出现不超过48小时；", "label": 1, "label_text": "Sign", "id": "s6371"}
{"text": " 2). HIV抗体确证试验阳性（W.B）或持有HIV感染者医疗证。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6372"}
{"text": " （6）年龄45～80岁，男女均可；", "label": 5, "label_text": "Multiple", "id": "s6373"}
{"text": " 3)确诊潜伏性结核：PPD实验呈强阳性（+++） 或 T-SPOT实验呈阳性（+）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6374"}
{"text": " （3）年龄&gt;=18岁；", "label": 3, "label_text": "Age", "id": "s6375"}
{"text": " 3.无严重脏器功能衰竭和活动性感染；", "label": 5, "label_text": "Multiple", "id": "s6376"}
{"text": " 18)签署知情同意书前1周内接受任何以提高血小板为目的的中草药或营养补充剂，维生素补充剂和矿物质补充剂除外。", "label": 5, "label_text": "Multiple", "id": "s6377"}
{"text": " 11、严重过敏体质者或曾用过试验药并对其组分过敏的受试者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6378"}
{"text": " 3符合便秘诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6379"}
{"text": "1.通过病理学明确的需要放疗的宫颈癌及子宫内膜癌肿瘤患者，患者可以为根治性放疗也可以为术后辅助放疗；", "label": 5, "label_text": "Multiple", "id": "s6380"}
{"text": " （4）经激素初始治疗达完全缓解（血小板≥100×109/L）的成人ITP患者；", "label": 5, "label_text": "Multiple", "id": "s6381"}
{"text": " 2．近半年内使用精神疾病类药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6382"}
{"text": " 3、年龄在18～65岁之间；", "label": 3, "label_text": "Age", "id": "s6383"}
{"text": " 3、CD4计数在500以下，且符合国家抗病毒治疗条件；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6384"}
{"text": "1. 受试者本人及其父母中的一方/监护人都必须能够理解并亲自签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6385"}
{"text": " 6、可能对免疫治疗过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6386"}
{"text": "1.病理诊断明确的盆、腹腔恶性肿瘤手术术后的患者（涵盖普外科、妇科、泌尿外科等科室，包括腔镜手术及开腹手术）", "label": 5, "label_text": "Multiple", "id": "s6387"}
{"text": " 6)骨扫描证实骨转移灶&gt;5个单位；", "label": 11, "label_text": "Diagnostic", "id": "s6388"}
{"text": "1.严重肝功能不全或肾功能不全者，白细胞数&lt;2.5×10 * 12，血小板计数&lt;6.0×10 * 9；", "label": 5, "label_text": "Multiple", "id": "s6389"}
{"text": " 2.  术后入ICU", "label": 26, "label_text": "Encounter", "id": "s6390"}
{"text": "（1）男性或女性，年龄30-85岁；", "label": 5, "label_text": "Multiple", "id": "s6391"}
{"text": " （4）近 14 天内有重大手术或严重创伤", "label": 5, "label_text": "Multiple", "id": "s6392"}
{"text": " 3 没有先心病及高反流误吸的患儿；", "label": 4, "label_text": "Disease", "id": "s6393"}
{"text": " 7.脑外伤及颅内高压者；", "label": 4, "label_text": "Disease", "id": "s6394"}
{"text": " 2.过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6395"}
{"text": " 10. AIDS或慢性丙型肝炎患者。", "label": 4, "label_text": "Disease", "id": "s6396"}
{"text": " （2）处于妊娠期或哺乳期；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6397"}
{"text": " 2.不同意进入临床试验者；", "label": 13, "label_text": "Consent", "id": "s6398"}
{"text": " 5. 本次入选前一年内在三甲医院进行胃镜、肠镜检查，排除胃肠器质性疾病；", "label": 5, "label_text": "Multiple", "id": "s6399"}
{"text": " 2.明确的过敏性病史，体位性低血压史，收缩压&lt;90mmHg；", "label": 4, "label_text": "Disease", "id": "s6400"}
{"text": " （5）ECOG评分0~2，预期生存期须≥3个月；", "label": 5, "label_text": "Multiple", "id": "s6401"}
{"text": "1.妊娠期、哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6402"}
{"text": "a. 感染、妊娠、分娩、外伤等应激状态者；", "label": 5, "label_text": "Multiple", "id": "s6403"}
{"text": " ⑥ 年龄在18～60岁之间；", "label": 3, "label_text": "Age", "id": "s6404"}
{"text": " 8、试验前4周内未因急性哮喘加重而住院治疗。", "label": 4, "label_text": "Disease", "id": "s6405"}
{"text": "⑴年龄为18-70岁的男性或女性患者；", "label": 5, "label_text": "Multiple", "id": "s6406"}
{"text": " 6. 患者入组前至少经过12周的维持透析治疗（3次透析/周），且计划在研究期间继续维持透析治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6407"}
{"text": "  2. 患者本人或监护人知情同意；", "label": 13, "label_text": "Consent", "id": "s6408"}
{"text": " 4.体内置入起搏器、复律器和除颤器等电子设备者。", "label": 34, "label_text": "Device", "id": "s6409"}
{"text": " 5.患者最佳矫正视力达到1.0或以上", "label": 12, "label_text": "Laboratory Examinations", "id": "s6410"}
{"text": " 7 需要口服抗凝血剂、抗血小板剂或者非甾体类抗炎药来治疗的患者。如果患者正在使用阿司匹林不必停药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6411"}
{"text": " 7.术前未在我院行胸部CT者；", "label": 34, "label_text": "Device", "id": "s6412"}
{"text": " （2）严重感染；", "label": 4, "label_text": "Disease", "id": "s6413"}
{"text": " 3.正在参加其他营养运动的干预项目。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6414"}
{"text": " c）本人长期居住于本社区，便于随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6415"}
{"text": " 7.合并幽门梗阻患者；", "label": 4, "label_text": "Disease", "id": "s6416"}
{"text": " 术治疗和（或）心脏永久性起搏器植入；", "label": 34, "label_text": "Device", "id": "s6417"}
{"text": " (3)晚期肿瘤、晚期白血病合并ARDS；", "label": 4, "label_text": "Disease", "id": "s6418"}
{"text": " ⑥年龄18～75 岁，无心、肺、肝、肾、血液系统其他严重疾患", "label": 5, "label_text": "Multiple", "id": "s6419"}
{"text": " b.签署知情同意书自愿参与本实验的患者；", "label": 13, "label_text": "Consent", "id": "s6420"}
{"text": " 5. 已签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6421"}
{"text": " 4 拒绝签署知情同意术的患者", "label": 13, "label_text": "Consent", "id": "s6422"}
{"text": " ②孕妇和哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6423"}
{"text": " 2.妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6424"}
{"text": " 17.受试者被确认有恶性肿瘤。", "label": 4, "label_text": "Disease", "id": "s6425"}
{"text": " 3.肺功能GOLD2-3级，同时综合评估B组或C组的慢性阻塞性肺疾病稳定期患者（根据GOLD 2017更新的综合评估 ABCD分组模式）；", "label": 5, "label_text": "Multiple", "id": "s6426"}
{"text": " 3）临床医生决定需要使用血必净注射液；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6427"}
{"text": " 6.ECOG PS：0-3分；", "label": 9, "label_text": "Risk Assessment", "id": "s6428"}
{"text": " 9、既往没有中枢神经疾病史，如不可控的脑转移、癫痫；", "label": 4, "label_text": "Disease", "id": "s6429"}
{"text": " （6）近3个月参加过临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6430"}
{"text": " ③宫颈细胞学检测结果为正常/炎性反应或ASC-US/LSIL行组织病理学检查结果为炎症者；", "label": 11, "label_text": "Diagnostic", "id": "s6431"}
{"text": " （2）男性或女性，性别不限", "label": 35, "label_text": "Gender", "id": "s6432"}
{"text": " (2) 患儿年龄1月-3y；", "label": 3, "label_text": "Age", "id": "s6433"}
{"text": " ④白细胞&gt;12×10^9/L或&lt;4×10^9/L,或幼稚杆状核白细胞&gt;10%。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6434"}
{"text": " ① 符合HBeAg阴性慢性乙型肝炎的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6435"}
{"text": " 2)基于双能X 线吸收法（DXA）测定，骨密度（BMD）测定腰椎L1-L4（有骨质增生和腰椎骨折等病史者可以剔除一个影响较大的腰椎）平均值T≤-2.5SD，或双髋骨股骨颈任一侧T≤-2.5SD；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6436"}
{"text": " 4、签署知情同意书", "label": 13, "label_text": "Consent", "id": "s6437"}
{"text": "1.脑转移患者", "label": 4, "label_text": "Disease", "id": "s6438"}
{"text": " 精神疾病史；", "label": 4, "label_text": "Disease", "id": "s6439"}
{"text": "年龄≥18年", "label": 3, "label_text": "Age", "id": "s6440"}
{"text": " 3原发肺动脉高压。", "label": 4, "label_text": "Disease", "id": "s6441"}
{"text": " (15)研究者认为不适合入组的其他情况。", "label": 21, "label_text": "Researcher Decision", "id": "s6442"}
{"text": "1）膝关节其他炎性疼痛性疾病：风湿/类风湿性关节炎，牛皮癣性关节炎，痛风，血友病性关节炎，感染性关节炎等。", "label": 4, "label_text": "Disease", "id": "s6443"}
{"text": " 4.受试者愿意签署知情同意书", "label": 13, "label_text": "Consent", "id": "s6444"}
{"text": " ③排除伴有其他严重的心脑肾等原发性疾病；", "label": 4, "label_text": "Disease", "id": "s6445"}
{"text": " 3.来我院就诊前未接受过系统治疗并愿意接受治疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6446"}
{"text": "1.曾经用过ATO后复发APL患儿", "label": 5, "label_text": "Multiple", "id": "s6447"}
{"text": " 2)  根据美国肾脏病基金会（NKF）制定的肾脏病生存质量指导（K/DOQI）指南诊断为慢性肾病（CKD）：", "label": 11, "label_text": "Diagnostic", "id": "s6448"}
{"text": "   1、各类型器质性疾病；", "label": 4, "label_text": "Disease", "id": "s6449"}
{"text": " 2.诊断符合GINA（2008）哮喘诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6450"}
{"text": " 8)在4周内使用过大量糖皮质激素或其他免疫抑制剂的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6451"}
{"text": " (4) 无法进行正常交流沟通的患者", "label": 25, "label_text": "Literacy", "id": "s6452"}
{"text": " (5) 从CT/MRI判断,无法估计血肿原始的位置;", "label": 11, "label_text": "Diagnostic", "id": "s6453"}
{"text": "(1)符合2型糖尿病诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s6454"}
{"text": " ④知情同意者。", "label": 13, "label_text": "Consent", "id": "s6455"}
{"text": " 2. 具有严重的原发性心、肝、肺、肾、血液或影响其生存的严重疾病。", "label": 4, "label_text": "Disease", "id": "s6456"}
{"text": " 6)总胆红素&gt;2倍正常上限（ULN）、和/或碱性磷酸酶或门冬氨酸转氨酶&gt;2.5 倍ULN（不包含淋巴瘤细胞肝占位引起的肝功能异常）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6457"}
{"text": " 6. 过去1个月内患有严重腹泻或便秘；", "label": 28, "label_text": "Symptom", "id": "s6458"}
{"text": " 3. 远处转移病灶：原则为转移灶可能进行放疗干预。【建议：转移器官数目≤3；肝脏转移病灶≤1、脑转移时神志清楚；肺内转移数目少不影响肺功能且可能进行原发灶和/或部分转移灶放疗；骨转移时无严重影响生存质量的不可逆事件发生（如：病理性骨折等）】；", "label": 5, "label_text": "Multiple", "id": "s6459"}
{"text": " （2）年龄大于40岁；", "label": 3, "label_text": "Age", "id": "s6460"}
{"text": " (5)妊娠、哺乳期或长期服用避孕药", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6461"}
{"text": " F.头颅MRI平扫和斜冠状位海马扫描检查：直径大于2cm的梗死灶少于或等于2个，无关键部位如丘脑、海马、内嗅皮质、旁嗅皮质、角回、皮质和皮质下其他灰质核团的梗死灶，脑白质损害Fazekas Scale分级＜2；MRI显示AD的可能性最大（内侧颞叶萎缩视觉评定量表 MTA分级为2级或更高）；", "label": 5, "label_text": "Multiple", "id": "s6462"}
{"text": "1.行择期大中手术的骨科住院患者。需纳入研究的手术类型如下：", "label": 0, "label_text": "Therapy or Surgery", "id": "s6463"}
{"text": " (5)1 分≤NIHSS 评分≤15分的轻、中度脑卒中者；", "label": 5, "label_text": "Multiple", "id": "s6464"}
{"text": " (3）经病理学明确诊断的IV期消化道肿瘤患者；", "label": 11, "label_text": "Diagnostic", "id": "s6465"}
{"text": " ④严重感染未得到控制的患者；", "label": 4, "label_text": "Disease", "id": "s6466"}
{"text": "(1)有除COPD外的其他肺疾病史（如支气管扩张、支气管哮喘、肺炎、肺栓塞、气胸）；", "label": 4, "label_text": "Disease", "id": "s6467"}
{"text": " 具有脑梗死或其他中枢神经系统疾病病史；", "label": 4, "label_text": "Disease", "id": "s6468"}
{"text": " ④近一周内未使用过任何治疗失眠的西药、成药、方药、中成药及汤剂者，或在短期((3-5天)内服用过以上药物，已停用7天以上者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6469"}
{"text": " （17）处于妊娠期、哺乳期或计划在研究期间妊娠的女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6470"}
{"text": " 2.有吸烟喝酒等嗜好的健康志愿者。", "label": 2, "label_text": "Addictive Behavior", "id": "s6471"}
{"text": " 9）抑郁发作具有季节性特点（符合DSM-IV“复发性抑郁，伴季节性特征”的标准）的抑郁障碍患者。", "label": 4, "label_text": "Disease", "id": "s6472"}
{"text": " 10. Q-T间期延长者或正用延长Q-T间期药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6473"}
{"text": "1）年龄14岁-75岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s6474"}
{"text": " ④排除代谢性疾病及全身自身免疫性疾病：如糖尿病、干燥综合征、系统性红斑狼疮、类风湿关节炎等。", "label": 4, "label_text": "Disease", "id": "s6475"}
{"text": " b)有生育能力女性开始服用试验药物前2周内未采取适当避孕措施者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6476"}
{"text": " 5. 不能完成超声心动图检查的患者", "label": 17, "label_text": "Capacity", "id": "s6477"}
{"text": "1.上消化道狭窄、吞咽困难；", "label": 4, "label_text": "Disease", "id": "s6478"}
{"text": " 4.自愿参加并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s6479"}
{"text": " （10）术后转入重症加强护理病房（intensive care unit, ICU）患者", "label": 26, "label_text": "Encounter", "id": "s6480"}
{"text": "      8) 休克，重要脏器衰竭，生命体征不稳定患者；", "label": 5, "label_text": "Multiple", "id": "s6481"}
{"text": " （4）Kellgren和Lawrecne骨关节炎放射学分级为Ⅱ级或Ⅲ级。", "label": 4, "label_text": "Disease", "id": "s6482"}
{"text": "1.入组前4接受过周内放射治疗（不包括对骨转移的局部放射治疗）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6483"}
{"text": "1）2019-2021年我中心确诊的CTEPH患者（根据国内肺动脉高压指南临床诊断标准），", "label": 26, "label_text": "Encounter", "id": "s6484"}
{"text": "1.肾脏损伤≥3个月，肾损伤的定义是肾脏结构或功能的异常，伴有或不伴有肾小球滤过率的下降，有下列证据", "label": 5, "label_text": "Multiple", "id": "s6485"}
{"text": " 13)存在不受控制的高血压或充血性心力衰竭，需要使用硝酸盐的活动性心绞痛，过去6个月内发生过心肌梗塞或需要积极治疗的心律失常或心力衰竭。", "label": 4, "label_text": "Disease", "id": "s6486"}
{"text": " 8．妊娠或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6487"}
{"text": " （3） 具有AECOPD诊治中国专家共识（2017修订版）推荐的接受抗菌药物治疗的指征；", "label": 11, "label_text": "Diagnostic", "id": "s6488"}
{"text": "1.缺血症状来源于穿支卒中，无低灌注引起症状的证据", "label": 4, "label_text": "Disease", "id": "s6489"}
{"text": " 9.患者同意参与该临床试验；", "label": 13, "label_text": "Consent", "id": "s6490"}
{"text": "1、EGFR基因突变阴性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6491"}
{"text": " ②已有精神疾患，不能按要求进行相关检查者；", "label": 5, "label_text": "Multiple", "id": "s6492"}
{"text": " (3)没有远处转移的证据;", "label": 24, "label_text": "Neoplasm Status", "id": "s6493"}
{"text": " 3、双眼中任何一眼散光大于1.5D；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6494"}
{"text": " 2.严重感染性疾病", "label": 4, "label_text": "Disease", "id": "s6495"}
{"text": " 6）肝肾功能严重异常者（严重肝功能异常：ALT、AST、ALP或TBIL其中任一项&gt;正常值上限2倍；严重肾功能异常：Cr清除率&lt;30 ml/min或血肌酐&gt;177umol/L）；", "label": 5, "label_text": "Multiple", "id": "s6496"}
{"text": " ③肥胖、肝、肾功能严重异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6497"}
{"text": " 2)术前24h使用了镇痛镇静药、镇吐药和抗瘙痒药物和喹诺酮类抗菌药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6498"}
{"text": "（1）年龄18-85岁", "label": 3, "label_text": "Age", "id": "s6499"}
{"text": " HBV DNA &lt;10, 000 IU/mL；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6500"}
{"text": " 2.意识清醒，无精神障碍，无严重心、肝、肾脏疾病的招募患者；", "label": 4, "label_text": "Disease", "id": "s6501"}
{"text": " （2）患者依从性差，不能进行随访。", "label": 8, "label_text": "Compliance with Protocol", "id": "s6502"}
{"text": " 5.就诊时间限定于伤后24h内。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6503"}
{"text": " 3.年龄40-70岁", "label": 3, "label_text": "Age", "id": "s6504"}
{"text": " 5.入院时已经出现肾功能衰竭或有严重肾功能不全病史（长期需要血液或腹膜透析者）", "label": 5, "label_text": "Multiple", "id": "s6505"}
{"text": " （2）儿童（患者小于18岁）、清醒开颅手术者；", "label": 5, "label_text": "Multiple", "id": "s6506"}
{"text": " e）无烟、酒嗜好；", "label": 2, "label_text": "Addictive Behavior", "id": "s6507"}
{"text": " 7、 产时并发症（ 如脐带脱垂、 产前急性失血）", "label": 4, "label_text": "Disease", "id": "s6508"}
{"text": " ③ 严重精神疾患或肢体残疾无法自行服药的患者。", "label": 5, "label_text": "Multiple", "id": "s6509"}
{"text": "1)前列腺穿刺病理确诊为前列腺癌", "label": 11, "label_text": "Diagnostic", "id": "s6510"}
{"text": " （5）研究人员认为其他原因不适合临床试验者", "label": 21, "label_text": "Researcher Decision", "id": "s6511"}
{"text": " 6)足够肝肾功能储备：肌酐≤1.0 ×  正常值上限，总胆红素≤2 × 正常值上限，AST和ALT≤2.0 × 正常值上限，AKP≤5 × 正常值上限。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6512"}
{"text": " （7）临床试验之前未接受过正规康复治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s6513"}
{"text": "1.经细胞学或组织病理学确诊的非小细胞肺癌局部晚期或晚期患者；", "label": 11, "label_text": "Diagnostic", "id": "s6514"}
{"text": " 3.  全麻时间≥3h。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6515"}
{"text": " 3.治疗开始前有串线未移除的；", "label": 1, "label_text": "Sign", "id": "s6516"}
{"text": "1) 对拟使用药物中的任何成分，有过敏史的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6517"}
{"text": " 4. 初次发生脑卒中；", "label": 4, "label_text": "Disease", "id": "s6518"}
{"text": " (2)合并冠心病、心肌梗死、重度心率失常，肝、肾、造血系统等严重并发症及严重精神障碍者(高血压患者血压超过160／90mmHg；ALT升高超过正常值上限1．5倍；BUN、Cr高于正常范围者。)；", "label": 5, "label_text": "Multiple", "id": "s6519"}
{"text": "1.胆道肿瘤合并梗阻性黄疸", "label": 4, "label_text": "Disease", "id": "s6520"}
{"text": " （2）当地常住居民，并在上述医院进行常规产检；", "label": 5, "label_text": "Multiple", "id": "s6521"}
{"text": " （3）具有青光眼性视野缺损；", "label": 4, "label_text": "Disease", "id": "s6522"}
{"text": " （11）活动性出血和消化道溃疡者；", "label": 4, "label_text": "Disease", "id": "s6523"}
{"text": " K 任何类型的癌症，皮肤癌除外，病人未接受积极治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s6524"}
{"text": " （4）卡氏评分≥70分。", "label": 9, "label_text": "Risk Assessment", "id": "s6525"}
{"text": " （5）合并心脑血管、肝、肾、造血系统等严重原发性疾病及精神病患者；", "label": 4, "label_text": "Disease", "id": "s6526"}
{"text": " [2]症状体征与影像学吻合;", "label": 11, "label_text": "Diagnostic", "id": "s6527"}
{"text": " 6、签署知情同意书", "label": 13, "label_text": "Consent", "id": "s6528"}
{"text": " （10）嗜酒或吸毒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s6529"}
{"text": " (1)高热或体温不升，怀疑或证实由感染引起；", "label": 5, "label_text": "Multiple", "id": "s6530"}
{"text": " 3）计划怀孕或孕期者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6531"}
{"text": " 8. 妊娠、哺乳期妇女或是拒绝避孕的适育期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6532"}
{"text": " ③BMI（体重÷身高2） 18.5~35 kg/m2", "label": 9, "label_text": "Risk Assessment", "id": "s6533"}
{"text": " 2.年龄大于18岁且小于60岁；", "label": 3, "label_text": "Age", "id": "s6534"}
{"text": " ③有眼部器质性病变，如视网膜疾病、白内障、上睑下垂等", "label": 4, "label_text": "Disease", "id": "s6535"}
{"text": " 6.可逆性原因（电解质紊乱、药物、中毒与感染等）引起的流出道室性心律失常；", "label": 4, "label_text": "Disease", "id": "s6536"}
{"text": "1. 适合常规内镜治疗者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6537"}
{"text": "（1）按临床标准或经病理活检获得明确诊断的原发性肝癌或转移性肝癌；", "label": 11, "label_text": "Diagnostic", "id": "s6538"}
{"text": " ⑶ 活动性的现症感染；", "label": 4, "label_text": "Disease", "id": "s6539"}
{"text": " (2) 以膝前痛为主的患者；", "label": 28, "label_text": "Symptom", "id": "s6540"}
{"text": "1)试验前3个月每日吸烟量多于5支者；", "label": 36, "label_text": "Smoking Status", "id": "s6541"}
{"text": " ②年龄大于18岁；", "label": 3, "label_text": "Age", "id": "s6542"}
{"text": " 8)精神意识障碍等难以对药物的有效性和安全性作确切评价者；", "label": 5, "label_text": "Multiple", "id": "s6543"}
{"text": "1.合并严重肝脏、胆囊、胰腺疾病患者；", "label": 4, "label_text": "Disease", "id": "s6544"}
{"text": "1)甲状腺单叶切除、次全切、双叶切除未进行中央区淋巴结清扫", "label": 0, "label_text": "Therapy or Surgery", "id": "s6545"}
{"text": " 2.患者近3天内接受过抗组胺药，皮质类固醇，免疫抑制剂治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6546"}
{"text": "① 已签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6547"}
{"text": " 4.识字且文化程度是初中或初中以上；", "label": 41, "label_text": "Education", "id": "s6548"}
{"text": " 2. 术前完成心理认知功能评估的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6549"}
{"text": " PegIFNα-2a治疗前从未用过或至少6个月内未接受过抗病毒治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6550"}
{"text": " 2.女性，年龄20-70岁", "label": 5, "label_text": "Multiple", "id": "s6551"}
{"text": " (5)有癫痫或其他中枢神经系统功能紊乱者；", "label": 4, "label_text": "Disease", "id": "s6552"}
{"text": "1.心肝肾等重要脏器有原发性疾病，有消化道疾病病史，有代谢性疾病病史、神经系统疾病史者。", "label": 4, "label_text": "Disease", "id": "s6553"}
{"text": " 3.签署书面知情同意书", "label": 13, "label_text": "Consent", "id": "s6554"}
{"text": " (iii)患者签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6555"}
{"text": " （2）冠心病、高血压以及肿瘤患者", "label": 4, "label_text": "Disease", "id": "s6556"}
{"text": " 8）有出血倾向或凝血功能障碍者；", "label": 5, "label_text": "Multiple", "id": "s6557"}
{"text": " 2. 术前行化疗或放疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6558"}
{"text": " 1.2.5单肢体损伤或双肢体损伤者；", "label": 4, "label_text": "Disease", "id": "s6559"}
{"text": " (12)研究者认为不适宜参加临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s6560"}
{"text": " 3.同意行肝脏活检穿刺术", "label": 13, "label_text": "Consent", "id": "s6561"}
{"text": " ①第一阶段入组的患者，经第二代抗精神病药单药治疗（可合并改良ECT治疗），病情基本缓解者（PANSS评分减分率≥50%）；", "label": 5, "label_text": "Multiple", "id": "s6562"}
{"text": " （4）排除腰背部、胸腹部受损或手术后患者；", "label": 5, "label_text": "Multiple", "id": "s6563"}
{"text": " （3）按相应临床诊断标准诊断代谢相关疾病的并发症，如采用尿白蛋白肌酐比值、眼底荧光造影及血管超声检查明确糖尿病肾病、糖尿病视网膜病变及糖尿病血管病变的诊断等；", "label": 11, "label_text": "Diagnostic", "id": "s6564"}
{"text": " ④愿意接受本次科研调查研究者；", "label": 13, "label_text": "Consent", "id": "s6565"}
{"text": " 4、对于局麻药过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s6566"}
{"text": " 4.患者的第1个 IVF/ICSI 周期，并符合以下指征之一：", "label": 0, "label_text": "Therapy or Surgery", "id": "s6567"}
{"text": " 不孕年限1年以上", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6568"}
{"text": " 3)脑肿瘤、鼻腔、鼻窦等不常规行颈部预防照射的肿瘤；", "label": 4, "label_text": "Disease", "id": "s6569"}
{"text": " （3） 已签署患者知情同意书", "label": 13, "label_text": "Consent", "id": "s6570"}
{"text": " ③患有其他严重疾病的病人，如癌症晚期和艾滋病等；", "label": 4, "label_text": "Disease", "id": "s6571"}
{"text": " 2. 有行IVF、ICSI或PESA/TESA助孕指征；", "label": 4, "label_text": "Disease", "id": "s6572"}
{"text": " 15.首次用药前4周内并发重度感染（如：需要静脉滴注抗生素、抗真菌或抗病毒药物），或在筛选期间/首次给药前出现不明原因的发热&gt;38.5°C；", "label": 5, "label_text": "Multiple", "id": "s6573"}
{"text": " 3 轻度至中度ED（国际勃起功能评分（IIEF-5）在8和21之间；", "label": 9, "label_text": "Risk Assessment", "id": "s6574"}
{"text": " 2.糖尿病患者；", "label": 4, "label_text": "Disease", "id": "s6575"}
{"text": " 3. 近6个月发生摔倒；", "label": 28, "label_text": "Symptom", "id": "s6576"}
{"text": " （3）B 超示肿瘤局限甲状腺内，每病灶最大径 ≤ 4cm；", "label": 11, "label_text": "Diagnostic", "id": "s6577"}
{"text": " 8)年龄18-65岁；", "label": 3, "label_text": "Age", "id": "s6578"}
{"text": " 8.血液检查：WBC ≥ 2.5×109/L，PLT ≥ 60×109/L，Hb ≥ 9.0g/dL，MID ≥1.0×109/L，LY ≥ 0.4×109/L，LY% ≥ 15%", "label": 12, "label_text": "Laboratory Examinations", "id": "s6579"}
{"text": " 4) TIPS术前2周内及术后使用抗生素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6580"}
{"text": " 5、怀疑或确有酒精、药物滥用病史；", "label": 2, "label_text": "Addictive Behavior", "id": "s6581"}
{"text": " 5、有回肠或结肠造口的需要或计划（包括腹会阴联合直肠癌根治术、保护性末端回肠造口等）", "label": 0, "label_text": "Therapy or Surgery", "id": "s6582"}
{"text": "年龄50-65岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s6583"}
{"text": " 2 肿瘤转移，胃排空梗阻，肿瘤侵犯胃，既往有胃切除史", "label": 5, "label_text": "Multiple", "id": "s6584"}
{"text": " 6.病人及家属同意参加本项研究，并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6585"}
{"text": " ④自愿受试并签署知情同意书者；", "label": 13, "label_text": "Consent", "id": "s6586"}
{"text": " 4 孕周+出生后年龄小于42周的早产儿", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6587"}
{"text": " （10）正在服用其他降糖药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6588"}
{"text": " （5）既往有异常手术麻醉恢复史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6589"}
{"text": "1.累及中枢神经系统的活动性狼疮；", "label": 4, "label_text": "Disease", "id": "s6590"}
{"text": " 2）心率&gt;90/分；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6591"}
{"text": " ④.主要脏器（心、肝、肺、肾）功能基本正常，PS评分：0-2级；", "label": 5, "label_text": "Multiple", "id": "s6592"}
{"text": " （4）有神经系统疾病史；慢性疼痛病史；药物成瘾及酗酒；长期应用阿片类药物史；", "label": 5, "label_text": "Multiple", "id": "s6593"}
{"text": " ④皮肤类型： Fitzpatrick皮肤分型1型到4型的患者。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6594"}
{"text": " 2.研究者判断受试者不适合参与研究。", "label": 21, "label_text": "Researcher Decision", "id": "s6595"}
{"text": "1)年龄≥18周岁；", "label": 3, "label_text": "Age", "id": "s6596"}
{"text": " 5）上气道梗阻患者；", "label": 4, "label_text": "Disease", "id": "s6597"}
{"text": " ⑤具有完全精神行事能力，理解并签署知情同意书，且愿意完成整个研究过程。", "label": 5, "label_text": "Multiple", "id": "s6598"}
{"text": " 2)消化道畸形（食管闭锁、食管气管瘘、胆道闭锁、先天性巨结肠、肛门闭锁、脐膨出、腹裂、先天性肠扭转不良等）；", "label": 4, "label_text": "Disease", "id": "s6599"}
{"text": " 8）无严重的精神疾病及无严重的心、肝、肾、肺功能不全，未合并其他有致命危险的疾病；", "label": 5, "label_text": "Multiple", "id": "s6600"}
{"text": " 7)尿妊娠试验阴性（育龄期女性），且在试验期间至试验结束后3个月内采取避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6601"}
{"text": " 3.上下唇突点位于E线前", "label": 28, "label_text": "Symptom", "id": "s6602"}
{"text": " 3、有LHRHa以及化疗禁忌证", "label": 4, "label_text": "Disease", "id": "s6603"}
{"text": " 3）因各种原因不能准确表述瘙痒程度的患者；", "label": 17, "label_text": "Capacity", "id": "s6604"}
{"text": " (3)、3个月内使用过激素( 全身性) 等影响糖代谢的药物;", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6605"}
{"text": " 4、患者年龄 15-75岁；", "label": 3, "label_text": "Age", "id": "s6606"}
{"text": " (9) 过敏体质，如对两种或以上药物、食物和花粉过敏者，或已知对本药物成分过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6607"}
{"text": " 8）不愿意或无法配合资料收集者；", "label": 13, "label_text": "Consent", "id": "s6608"}
{"text": " 7  已知对可能使用的化疗药物过敏的；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6609"}
{"text": " 4.妊娠或哺乳期或产后至多 6 周或已停止哺乳 6 周的女性受试者。如果发现女性受 试者在参加某一项检查的时候妊娠，则在分析中剔除该项检查数据。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6610"}
{"text": "头颅CT或头部MRI显示脑出血（非脑梗死伴出血转化）", "label": 5, "label_text": "Multiple", "id": "s6611"}
{"text": " 5.筛选期（即治疗阶段开始前的14±3天期间）患者完整完成症状日志记录至少10天；", "label": 22, "label_text": "Data Accessible", "id": "s6612"}
{"text": " ?骨髓功能正常。血常规：中性粒细胞≥2.5×109/L，血红蛋白≥100g/L，血小板≥100×109/L，无凝血功能异常；", "label": 5, "label_text": "Multiple", "id": "s6613"}
{"text": "1. 既往造影剂或示踪剂过敏者禁忌，有其他过敏性病史者据情况排除；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6614"}
{"text": " 3、尿道功能障碍患者；", "label": 4, "label_text": "Disease", "id": "s6615"}
{"text": " 7）受试者无主要器官功能受损", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6616"}
{"text": "（1）近6个月内曾接受含有左旋门冬酰胺酶化疗的复发或疾病进展患者。", "label": 5, "label_text": "Multiple", "id": "s6617"}
{"text": " 2.B超/CT/MRI提示胰腺实性占位，需要行EUS-FNA明确性质；EUS明确证实，且病灶长轴直径&gt;1 cm。EUS影像中病灶以实性成分为主（实性回声/囊性回声&gt;60％，即在实性占位中，部分病灶可因出现坏死液化而在超声影像中有囊性回声）", "label": 11, "label_text": "Diagnostic", "id": "s6618"}
{"text": " 3.术后在重症加强护理病房(ICU)停留时间至少5天。", "label": 26, "label_text": "Encounter", "id": "s6619"}
{"text": " （5）知情同意，并书面签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6620"}
{"text": " （2）患者有保乳意愿；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s6621"}
{"text": " 3. 病理证实激素受体（ER和PR 阴性）且HER2 阴性晚期乳腺癌；如有多次病理结果，三阴乳腺癌的定义以最后一次活检病理分子亚型结果为最终亚型。", "label": 11, "label_text": "Diagnostic", "id": "s6622"}
{"text": " d)之前未因任何肿瘤而进行放化疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6623"}
{"text": "1.正在进行抗凝治疗的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6624"}
{"text": " 5.肝功能（谷丙转氨酶、谷草转氨酶≤2.5倍正常值上限）", "label": 5, "label_text": "Multiple", "id": "s6625"}
{"text": " 4）本次治疗1月内气道内未接受任何局部治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s6626"}
{"text": " 2）术前2周呼吸道感染。", "label": 4, "label_text": "Disease", "id": "s6627"}
{"text": " ① 并发有其他如骨关节结核、肿瘤、风湿和类风湿关节炎等不属于骨性关节炎的患者；", "label": 4, "label_text": "Disease", "id": "s6628"}
{"text": " （5）预计手术时间小于150min者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6629"}
{"text": " （5）急性心肌梗死伴机械并发症（包括：室间隔穿孔、乳头肌断裂等）；", "label": 4, "label_text": "Disease", "id": "s6630"}
{"text": "1. 原发性脑瘤或中枢神经转移瘤病情未控者；", "label": 4, "label_text": "Disease", "id": "s6631"}
{"text": " 2. 血管外科或心脏外科大手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6632"}
{"text": " 9.知情同意并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6633"}
{"text": " 8.全身有较大伤口或切口未愈合者；", "label": 28, "label_text": "Symptom", "id": "s6634"}
{"text": " (5)合并严重呼吸功能不全（PO2&lt;60mmHg,即8.0Kpa；或PCO2&gt;50 mmHg ,即6.5Kpa）。", "label": 5, "label_text": "Multiple", "id": "s6635"}
{"text": " 2，结石位于肾脏或输尿管", "label": 4, "label_text": "Disease", "id": "s6636"}
{"text": " ⑤合并严重的心血管、脑血管、肝、肾、造血系统等原发性疾病或全身衰竭者，糖尿病（血糖控制不良，空腹血糖&gt;10umol/l）、恶性肿瘤、精神病患者；", "label": 4, "label_text": "Disease", "id": "s6637"}
{"text": " 3.入组前正在服用治疗冠心病中药的患者应至少停药1周，按规范服用不稳定性心绞痛二级预防治疗。", "label": 5, "label_text": "Multiple", "id": "s6638"}
{"text": " （4）受试者完全理解并自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6639"}
{"text": " （2）FMA小于36.3°；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6640"}
{"text": " 3）适合经皮冠状动脉介入治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s6641"}
{"text": " 10. Fitzpatrick皮肤分型为5，6型的患者或治疗前的4周内有过晒黑或者美黑的患者。因为皮肤中过高的黑色素密度可能会由于OPT作用引起皮肤色素改变。同时，深色皮肤吸收更多能量，可能会引起对皮肤不安全的升温过高。", "label": 5, "label_text": "Multiple", "id": "s6642"}
{"text": " （2）生后5分钟Apgar评分大于7；", "label": 9, "label_text": "Risk Assessment", "id": "s6643"}
{"text": " （2）已知对该疫苗所含任何成分，包括辅料以及抗生素过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6644"}
{"text": " 抗凝期间的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6645"}
{"text": " e) 既往无重症肌无力等影响肌肉神经接头传递等疾病", "label": 4, "label_text": "Disease", "id": "s6646"}
{"text": " ④认知功能障碍等严重到无法进行本科题的相关训练和评定，如MMSE评分＜22分；", "label": 5, "label_text": "Multiple", "id": "s6647"}
{"text": " 3.有白内障、青光眼等眼科疾病者；", "label": 4, "label_text": "Disease", "id": "s6648"}
{"text": " （7）肾功能不全，Cr＞300，或需要紧急CRRT者；", "label": 5, "label_text": "Multiple", "id": "s6649"}
{"text": " 2.Karnofsky评分≥80分", "label": 9, "label_text": "Risk Assessment", "id": "s6650"}
{"text": " 放疗、化疗、射频消融、肝动脉栓塞等微创治疗的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6651"}
{"text": " 3) 依从性差，不能按照研究方案完成实验者", "label": 8, "label_text": "Compliance with Protocol", "id": "s6652"}
{"text": " 2. 患者接受综合肺康复干预(CPR 组)或既无运动康复也无药物干预者(non-CPR组)", "label": 0, "label_text": "Therapy or Surgery", "id": "s6653"}
{"text": " （3）术前肝功能为Child’s Pugh 分级A级（5,6）或者B7（无腹水），BCLC 分期为A或B期的患者；", "label": 5, "label_text": "Multiple", "id": "s6654"}
{"text": " 9. 吸烟或喝酒者；", "label": 5, "label_text": "Multiple", "id": "s6655"}
{"text": " （1）年龄＜40岁；", "label": 3, "label_text": "Age", "id": "s6656"}
{"text": "1.女性", "label": 35, "label_text": "Gender", "id": "s6657"}
{"text": " （2）确诊进行性神经系统或精神性疾病，药物滥用史；", "label": 5, "label_text": "Multiple", "id": "s6658"}
{"text": "1）同时使用其它血液净化法并对试验的评价有影响的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6659"}
{"text": " 6)GCP规定，患者自愿参加，并签订知情同意书。", "label": 13, "label_text": "Consent", "id": "s6660"}
{"text": "1）男性或女性，年龄16～60岁。", "label": 5, "label_text": "Multiple", "id": "s6661"}
{"text": " ③ 曾患其它肿瘤并接受化疗和腹部放疗患者", "label": 5, "label_text": "Multiple", "id": "s6662"}
{"text": " 4.现正怀孕者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6663"}
{"text": "  (5)长期酗酒;", "label": 2, "label_text": "Addictive Behavior", "id": "s6664"}
{"text": " （4）慢性肝衰竭", "label": 4, "label_text": "Disease", "id": "s6665"}
{"text": " 8.在参加本试验前1月内曾参加其他药物临床试验或正在参加其他临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6666"}
{"text": "   肿瘤直径≤3cm；", "label": 24, "label_text": "Neoplasm Status", "id": "s6667"}
{"text": " 7. 免疫缺陷和自身免疫性疾病", "label": 4, "label_text": "Disease", "id": "s6668"}
{"text": "2.4.1符合西医的脑出血、脑梗死诊断；", "label": 11, "label_text": "Diagnostic", "id": "s6669"}
{"text": " 3.心、肺、肝、肾无严重器质性病变者，血液学检查符合以下标准；", "label": 5, "label_text": "Multiple", "id": "s6670"}
{"text": " 4.其他原因造成研究者认为不适合入组实验的情况 。", "label": 21, "label_text": "Researcher Decision", "id": "s6671"}
{"text": " ⑹所使用的化疗方案中，至少包含有一种属于“高致吐风险”级别的化疗药物，包括顺铂、多柔比星≥60 mg/m2、表柔比星＞90mg / m2、异环磷酰胺≥2g/m2，高致吐性化疗药物使用天数为3~5天；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6672"}
{"text": " ② 新鲜、闭合或者Gustilo I型、II型的四肢非近端骨折。", "label": 4, "label_text": "Disease", "id": "s6673"}
{"text": " 3.既往接受肺叶切除手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6674"}
{"text": " （5）既往对受试药物或其所含成分有过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6675"}
{"text": " 2.根据第四届全国脑血管病学术会议《各类脑血管病诊断要点》诊断为急性缺血性卒中（脑梗塞）；", "label": 11, "label_text": "Diagnostic", "id": "s6676"}
{"text": " 4. 之前使用过化疗药物(双膦酸盐除外)", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6677"}
{"text": " (4)根据RECIST 标准有可测量的肿瘤病灶。", "label": 11, "label_text": "Diagnostic", "id": "s6678"}
{"text": " ③ 存在限制性或阻塞性肺部疾病或需要呼吸机支持的呼吸衰竭；", "label": 4, "label_text": "Disease", "id": "s6679"}
{"text": " 4.签署知情同意书，愿意参加该试验", "label": 13, "label_text": "Consent", "id": "s6680"}
{"text": " （13）研究入组前已从既往治疗的相关毒性中恢复", "label": 0, "label_text": "Therapy or Surgery", "id": "s6681"}
{"text": "多发性肝脓肿", "label": 4, "label_text": "Disease", "id": "s6682"}
{"text": " （5）生育年龄的女性妊娠试验必须为阴性；或者男女患者需同意在治疗期间及随后的1年内使用有效的避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6683"}
{"text": "   1、18-65周岁", "label": 3, "label_text": "Age", "id": "s6684"}
{"text": "1.近期有接受造血干细胞移植计划的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6685"}
{"text": " （3）针刺部位感染", "label": 4, "label_text": "Disease", "id": "s6686"}
{"text": " ④非早期乳腺癌病例；", "label": 4, "label_text": "Disease", "id": "s6687"}
{"text": " ①因病、婚、产、事假在家休息、外出进修护士或护工", "label": 26, "label_text": "Encounter", "id": "s6688"}
{"text": " 3.患者合并有未控制的或严重的心血管疾病，包括在入组前6个月内的心肌梗塞，纽约心脏病学会(NYHA)定义（附录3）的III–IV级心衰、未控制的心绞痛、临床显著的心包疾病或心脏淀粉样变性；", "label": 5, "label_text": "Multiple", "id": "s6689"}
{"text": " e)B超检查高回声的黏膜下层结构局部或全部消失，或进行性肿大", "label": 11, "label_text": "Diagnostic", "id": "s6690"}
{"text": "（1）符合中华人民共和国医政司编写的《恶性肿瘤诊治规范》中的诊断标准，明确诊断为恶性肿瘤患者。", "label": 11, "label_text": "Diagnostic", "id": "s6691"}
{"text": " 经头颅CTA或DSA确诊为动脉瘤性蛛网膜下腔出血", "label": 11, "label_text": "Diagnostic", "id": "s6692"}
{"text": " （8）已知的严重肝功能不全，谷丙转氨酶(ALT)＞正常值的 3 倍或合并肝硬化者；", "label": 5, "label_text": "Multiple", "id": "s6693"}
{"text": "1.重型血友病A患儿（FVIII:C&lt;1%）；", "label": 4, "label_text": "Disease", "id": "s6694"}
{"text": "1. 符合肱二头肌长头肌腱炎的诊断：长期的摩擦或过度活动可引起腱鞘充血、水肿、增厚，造成腱鞘滑膜层急性水肿或慢性损伤性炎症，从而导致肱二头肌长头肌腱在腱鞘内的滑动功能发生障碍，从而出现临床症状；", "label": 11, "label_text": "Diagnostic", "id": "s6695"}
{"text": " (6) 孕周≥34周、出生体重≥2000 g或剖宫产(包括晚期早产和足月产儿、双胎和单胎);", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6696"}
{"text": "1）表观正常的人群和有典型糖尿病症状的人群；", "label": 5, "label_text": "Multiple", "id": "s6697"}
{"text": "1)未分化关节炎：关节肿痛≥1个，持续时间≥6周，且不符合任何一种已知的关节炎或弥漫性风湿病的诊断标准。", "label": 5, "label_text": "Multiple", "id": "s6698"}
{"text": " （8）对血脂康可能过敏。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6699"}
{"text": " 5.有明显出血倾向及血液性疾病的患者；", "label": 4, "label_text": "Disease", "id": "s6700"}
{"text": "① 符合再生障碍性贫血（髓劳病）急性重型的诊断标准，疾病处于造血恢复早期阶段；", "label": 5, "label_text": "Multiple", "id": "s6701"}
{"text": " (3)凝血功能指标在正常范围内，例外情况下（由医生判断）与标准区域有偏差可以接受", "label": 5, "label_text": "Multiple", "id": "s6702"}
{"text": " 3 常规治疗对外周血EBV无效", "label": 5, "label_text": "Multiple", "id": "s6703"}
{"text": " ②具有完整的临床病理资料、清晰的内镜图像以及相应的辅助检查结果。", "label": 22, "label_text": "Data Accessible", "id": "s6704"}
{"text": " 12. 精神障碍或沟通障碍者；", "label": 5, "label_text": "Multiple", "id": "s6705"}
{"text": " 6)或在入选本试验前1个月内使用过其他试验性药物者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6706"}
{"text": " 血压正常者的纳入标准:", "label": 12, "label_text": "Laboratory Examinations", "id": "s6707"}
{"text": " (7)2周内曾用激素、维甲酸类等外用药物或紫外光治疗者；4 周内曾接受系统治疗者；12周内曾使用生物制剂治疗者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6708"}
{"text": " 2.对临床研究知情且自愿参加者；", "label": 13, "label_text": "Consent", "id": "s6709"}
{"text": " 6.具有精神病史、对抗性格、不良动机、多疑或其他情感或智力问题，可能影响参与研究的知情有效性。", "label": 4, "label_text": "Disease", "id": "s6710"}
{"text": " ? 允许骨转移患者接受局部放疗姑息治疗者入组；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6711"}
{"text": " 1.3既往30天内参加过其他临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6712"}
{"text": " 2. 神经功能缺损由脑肿瘤、脑外伤、心脏病、等疾病引起；", "label": 4, "label_text": "Disease", "id": "s6713"}
{"text": "1、既往剖宫产史、子宫肌瘤剔除术史者、子宫纵膈切除术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6714"}
{"text": "（1）风湿免疫性疾病所致的肘关节功能障碍、退行性关节炎所致的肘关节功能障碍、感染性肘关节功能障碍、先天性肘关节功能障碍；", "label": 4, "label_text": "Disease", "id": "s6715"}
{"text": " 3、除肾癌之外有同时合并其他活跃的恶性肿瘤疾病或5年内有其他恶性肿瘤疾病史；", "label": 4, "label_text": "Disease", "id": "s6716"}
{"text": "1)年龄18-80岁，男女不限", "label": 5, "label_text": "Multiple", "id": "s6717"}
{"text": " ②符合慢性肾脏病（CKD）3～5期，未行肾脏替代治疗；", "label": 5, "label_text": "Multiple", "id": "s6718"}
{"text": " 2. 精神性疾病；", "label": 4, "label_text": "Disease", "id": "s6719"}
{"text": " 2.年龄在18-70岁；", "label": 3, "label_text": "Age", "id": "s6720"}
{"text": " 3.伴发其他影响听力疾病的患者", "label": 4, "label_text": "Disease", "id": "s6721"}
{"text": " 4)妊娠期妇女、哺乳期妇女、计划妊娠妇女、月经期妇女或近期有生育计划者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6722"}
{"text": " (5) 患者的监护人同意参加本研究并且签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6723"}
{"text": " （3）严重瓣膜性心脏病；", "label": 4, "label_text": "Disease", "id": "s6724"}
{"text": " 5.预期寿命少于6个月", "label": 23, "label_text": "Life Expectancy", "id": "s6725"}
{"text": " 7.继发性高血压患者。", "label": 4, "label_text": "Disease", "id": "s6726"}
{"text": " 8.最近14日内曾服用过对过敏性鼻炎可引起作用的中药制剂者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6727"}
{"text": " （2）无手术禁忌症。", "label": 4, "label_text": "Disease", "id": "s6728"}
{"text": " 6、能够遵守方案规定的研究程序和访视计划；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6729"}
{"text": " 4) 患有生殖系统肿瘤或明确有生殖系统肿瘤家族史。", "label": 4, "label_text": "Disease", "id": "s6730"}
{"text": " （2）重度吸烟（大于10支/天）及酗酒患者", "label": 2, "label_text": "Addictive Behavior", "id": "s6731"}
{"text": " 2）患侧肢体存在踝关节或足部明显骨性畸形；", "label": 4, "label_text": "Disease", "id": "s6732"}
{"text": "1）正参加其它临床试验的患者", "label": 15, "label_text": "Enrollment in other studies", "id": "s6733"}
{"text": " 3. 血压控制不好（SBP≥180mmHg 或DBP≥110mmHg）或高血压合并心脏扩大；", "label": 4, "label_text": "Disease", "id": "s6734"}
{"text": " 中途退出者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6735"}
{"text": " （3）确诊为感染性肠炎、甲状腺功能亢进者或其他影响胃肠道转运或功能的疾病；", "label": 4, "label_text": "Disease", "id": "s6736"}
{"text": " （1）影像学确定急性缺血性脑卒中", "label": 11, "label_text": "Diagnostic", "id": "s6737"}
{"text": "⑴ 心功能Ⅳ级（NYHA分级法）的患者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6738"}
{"text": "1. 合并其他慢性疾病并处于非稳定期，会加重化疗副反应的疾病。", "label": 5, "label_text": "Multiple", "id": "s6739"}
{"text": "(1)对局部浸润注射药物成份或赋形剂中任何成份有过敏史的患者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6740"}
{"text": " 15)研究者认为不宜参加本研究，例如：健康状况，依从性差，不愿或无能力遵守治疗方案，包括不能按时访视。", "label": 21, "label_text": "Researcher Decision", "id": "s6741"}
{"text": " 7)近3个月参加过临床试验；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6742"}
{"text": " 2）经临床及肾活检病理学诊断为特发性膜性肾病；", "label": 11, "label_text": "Diagnostic", "id": "s6743"}
{"text": " 7）有影响痉挛治疗发作的其他疾病者；", "label": 5, "label_text": "Multiple", "id": "s6744"}
{"text": " ③血压升高， 收缩压≥130 mmHg 或舒张压≥85mmHg， 或已经接受相应的治疗， 或此前已经诊断为高血压病；", "label": 5, "label_text": "Multiple", "id": "s6745"}
{"text": "（1）自愿参加本试验并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6746"}
{"text": " （3）签署知情同意书，患者自愿接受介入封堵治疗。", "label": 13, "label_text": "Consent", "id": "s6747"}
{"text": " 3.入院时已发生严重消化道出血、有慢性胃肠道疾病或曾行胃肠道手术治疗", "label": 5, "label_text": "Multiple", "id": "s6748"}
{"text": " （8）血液系统疾病；", "label": 4, "label_text": "Disease", "id": "s6749"}
{"text": " (5)正在参与其他手足口病临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6750"}
{"text": " (9)药物滥用者、烟酒嗜好者；", "label": 2, "label_text": "Addictive Behavior", "id": "s6751"}
{"text": " c. 无过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6752"}
{"text": " 5.年龄18~70岁，性别不限", "label": 5, "label_text": "Multiple", "id": "s6753"}
{"text": " 3）星状神经节阻滞失败的", "label": 0, "label_text": "Therapy or Surgery", "id": "s6754"}
{"text": "     有郁怒、多虑、忧愁等情志所伤史。", "label": 28, "label_text": "Symptom", "id": "s6755"}
{"text": " 15　由研究者判断不能坚持随访者。", "label": 21, "label_text": "Researcher Decision", "id": "s6756"}
{"text": "（1）符合ITP西医诊断标准，且中医辨证属气阴两虚型", "label": 11, "label_text": "Diagnostic", "id": "s6757"}
{"text": " 4.使用免疫抑制的药物如激素、化疗药物等；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6758"}
{"text": " 5、自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6759"}
{"text": " 4)目标眼有视网膜脱离或IMH病史，有视网膜色素上皮撕裂、黄斑区视网膜牵拉、视网膜劈裂或黄斑前膜；", "label": 4, "label_text": "Disease", "id": "s6760"}
{"text": "（1）存在头颅磁共振的禁忌症；", "label": 4, "label_text": "Disease", "id": "s6761"}
{"text": "①关节型、脓疱型、红皮病型银屑病以及特殊部位银屑病，包括颜面、头皮、指甲、皱折、龟头、掌跖部位。", "label": 4, "label_text": "Disease", "id": "s6762"}
{"text": " 1、测体温、行VAS评分、红外热图检查，结合验血结果决定是否追加凝血因子，保持凝血因子活性&gt;1%。", "label": 5, "label_text": "Multiple", "id": "s6763"}
{"text": " 4.合并活动性甲肝、丙肝、丁肝和/或HIV感染", "label": 4, "label_text": "Disease", "id": "s6764"}
{"text": " 6.合并其它影响语言功能的疾病，合并其它影响认知功能的疾病。", "label": 4, "label_text": "Disease", "id": "s6765"}
{"text": " （5）患者的性别尽量平均，男女各150例左右。", "label": 35, "label_text": "Gender", "id": "s6766"}
{"text": "1. 年龄3月～3岁；", "label": 3, "label_text": "Age", "id": "s6767"}
{"text": " F.有严重肺气肿、肺淤血和肺心病者。", "label": 4, "label_text": "Disease", "id": "s6768"}
{"text": " -同时参加其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6769"}
{"text": " 4. 患者希望在近处、中间距离和远处均能获得良好视力，降低残余散光，并减少对眼镜的依赖；", "label": 5, "label_text": "Multiple", "id": "s6770"}
{"text": " 4.3个月内计划进入透析治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s6771"}
{"text": " 4、年龄在18周岁至68周岁之间的痛风患者；", "label": 5, "label_text": "Multiple", "id": "s6772"}
{"text": " 3.存在冠脉病变需行冠脉内药物涂层支架植入术", "label": 5, "label_text": "Multiple", "id": "s6773"}
{"text": " 7)能理解本研究的情况并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6774"}
{"text": " 3.局麻药过敏，复合麻醉失败", "label": 7, "label_text": "Allergy Intolerance", "id": "s6775"}
{"text": " 4.静息痛VAS疼痛指数≥3分者；", "label": 9, "label_text": "Risk Assessment", "id": "s6776"}
{"text": " ③参与过其他心理干预的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6777"}
{"text": " G． 能获取完整的随访信息，能理解本研究的情况并签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s6778"}
{"text": " 12.在服用研究药物前48 小时摄取了任何含咖啡因、或含黄嘌呤食物或饮料。", "label": 18, "label_text": "Diet", "id": "s6779"}
{"text": " 2.受试者已签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6780"}
{"text": " （3）术前合并严重肝肾功能不全者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6781"}
{"text": " ③硬膜外穿刺禁忌，非甾体类抗炎药使用禁忌；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6782"}
{"text": " 3)曾有复发性自然流产史的患者；", "label": 4, "label_text": "Disease", "id": "s6783"}
{"text": " 10. 术前3月内新发脑卒中者；", "label": 4, "label_text": "Disease", "id": "s6784"}
{"text": " 对照组：同期招募年龄、性别相匹配且无任何消化道症状与其他疾病的健康志愿者。", "label": 5, "label_text": "Multiple", "id": "s6785"}
{"text": " 6.伴有脑、骨转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s6786"}
{"text": " （4）随机血糖≥13.7mmol/L的糖尿病患者或糖化血红蛋白≥9.5%；", "label": 5, "label_text": "Multiple", "id": "s6787"}
{"text": " ③入组前1个月使用激素及免疫抑制剂治疗；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6788"}
{"text": " （4）已确诊合并阿尔茨海默病、额颞叶痴呆、尼曼-匹克病等非帕金森综合征谱系的认知障碍疾病；", "label": 4, "label_text": "Disease", "id": "s6789"}
{"text": " 3.符合AECOPD（咳嗽、咳痰、呼吸困难加重需要更改治疗方案）,且伴有呼吸性酸中毒 (pH≤7.35，PaCO2&gt;50mmHg) 。", "label": 5, "label_text": "Multiple", "id": "s6790"}
{"text": " (3) ECOG评分:0-2；", "label": 9, "label_text": "Risk Assessment", "id": "s6791"}
{"text": " 2)有特异性变态反应病史（哮喘、风疹、湿疹性皮炎）、心律失常、心动过缓、低血压、冠心病、支气管和心血管疾病史，糖尿病、甲状腺功能亢进、帕金森综合症、癫痫、震颤麻痹或者能够干扰试验结果的任何其他疾病或生理情况；", "label": 4, "label_text": "Disease", "id": "s6792"}
{"text": "1.生殖道炎症者（淋病、衣原体感染、念珠菌阴道炎、滴虫性阴道炎、细菌性阴道病等）；", "label": 4, "label_text": "Disease", "id": "s6793"}
{"text": " q)试验前3个月内参与献血者；", "label": 14, "label_text": "Blood Donation", "id": "s6794"}
{"text": " ③严重视听障碍", "label": 4, "label_text": "Disease", "id": "s6795"}
{"text": " (5)葡萄膜炎病史；", "label": 4, "label_text": "Disease", "id": "s6796"}
{"text": " 3.自愿参加本研究并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6797"}
{"text": " 10.目前存在需要治疗的心脏病或控制不佳的高血压患者", "label": 4, "label_text": "Disease", "id": "s6798"}
{"text": " ③ 目前在使用β受体阻断剂治疗的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6799"}
{"text": " 9. 每日饮酒白酒大于50ml；葡萄酒大于100ml；啤酒大于300ml;", "label": 39, "label_text": "Alcohol Consumer", "id": "s6800"}
{"text": "1 有糖尿病、高血脂症、心脑血管病、严重肝肾功能患者。", "label": 5, "label_text": "Multiple", "id": "s6801"}
{"text": " 8.甲状腺功能性疾病；", "label": 4, "label_text": "Disease", "id": "s6802"}
{"text": " 8、因房颤或其他原因需长期服用华法令者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6803"}
{"text": " 2.至少有一个可测量病灶（满足RECIST 1.1标准）；未发生远处转移，未接受过手术、化疗、放疗及其他治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s6804"}
{"text": " 4.对蒽环类化疗药物存在禁忌", "label": 4, "label_text": "Disease", "id": "s6805"}
{"text": " 5. 胰管直径≥2mm；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6806"}
{"text": " 3）既往冠脉造影阳性（冠状动脉直径变窄大于等于 50%）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6807"}
{"text": " 7)心电图异常（具有临床意义）或生命体征异常者（收缩压&lt;90 mmHg或&gt;140 mmHg，舒张压&lt;50 mmHg或&gt;90 mmHg；心率&lt;50 bpm或&gt;100 bpm）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6808"}
{"text": "1.移植患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6809"}
{"text": " ④ ASA Ⅰ或 Ⅱ 级；", "label": 9, "label_text": "Risk Assessment", "id": "s6810"}
{"text": " 3.口鼻咽部肿瘤；", "label": 4, "label_text": "Disease", "id": "s6811"}
{"text": " ②留取大便的儿童2周内出现腹泻及服用抗生素，有应激状态（创伤、严重感染等），伴有腹痛、便秘或腹泻等胃肠道症状，开始研究前一个月曾接受过疫苗接种。", "label": 5, "label_text": "Multiple", "id": "s6812"}
{"text": " 3. 新生儿窒息( Apgar评分1分钟＜7分)；", "label": 9, "label_text": "Risk Assessment", "id": "s6813"}
{"text": "  8．三个月内参加过其它临床试验者", "label": 15, "label_text": "Enrollment in other studies", "id": "s6814"}
{"text": " (3)足月妊娠（37周≤孕周&lt;42周）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6815"}
{"text": "1) 有特定过敏史者（哮喘、麻疹、湿疹等），或过敏体质（如对两种或以上药物、食物和花粉过敏者，或已知对本药组分或类似物过敏者）；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6816"}
{"text": " (4)签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6817"}
{"text": " 2) 粪便筛查或痰培养或血培养有G-菌如大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、鲍曼不动杆菌、铜绿假单胞菌等阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6818"}
{"text": "1)术前存在泌尿系感染", "label": 4, "label_text": "Disease", "id": "s6819"}
{"text": " 3. 手法复位成功后主诉有残余症状", "label": 5, "label_text": "Multiple", "id": "s6820"}
{"text": " 10 实验室检查：总胆红素＞2倍正常值上限(ULN)；AST和/或ALT＞2.倍正常值上限（ULN）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6821"}
{"text": "1)不符合入组标准的病理类型以及临床分期者。", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6822"}
{"text": " 2) 肝功显著异常或有下列肝病病史：AST或ALT高于正常值上限的2 倍，肝硬化、肝性脑病史，食管静脉曲张史或门脉分流史。", "label": 5, "label_text": "Multiple", "id": "s6823"}
{"text": "（1）患者要求退出；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6824"}
{"text": "① 先天性生殖器官发育异常，或子宫、双侧卵巢或双侧输卵管切除患者；", "label": 5, "label_text": "Multiple", "id": "s6825"}
{"text": "①性别不限，年龄小于60岁初发或1个标准化疗疗程未缓解AML患者；", "label": 5, "label_text": "Multiple", "id": "s6826"}
{"text": " 2.手术后仍有伤口不愈合者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6827"}
{"text": " 2. 妊娠", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6828"}
{"text": "1.合并肝癌和其他部位恶性肿瘤", "label": 4, "label_text": "Disease", "id": "s6829"}
{"text": " （3）慢性心衰急性失代偿或急性新发心衰；", "label": 4, "label_text": "Disease", "id": "s6830"}
{"text": " 3. 处于妊娠或哺乳期的女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6831"}
{"text": "a.年龄18-60岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s6832"}
{"text": " c. 精神病或严重心理疾病患者；", "label": 4, "label_text": "Disease", "id": "s6833"}
{"text": "1、脑出血；", "label": 4, "label_text": "Disease", "id": "s6834"}
{"text": " 4)癌症患者", "label": 4, "label_text": "Disease", "id": "s6835"}
{"text": " 2CT检查显示腰椎间盘突出较大，椎管狭窄，临床出现二便失禁、性功能障碍、下肢瘫痪；疼痛剧烈经保守治疗3个月以上无效，需手术治疗者；", "label": 5, "label_text": "Multiple", "id": "s6836"}
{"text": " 11.目前使用香豆素（或华法林）或在手术时间超过6个月的肝素治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6837"}
{"text": " （4）患者已知患有高钙血症，肾功能障碍及结石；", "label": 5, "label_text": "Multiple", "id": "s6838"}
{"text": " 7.实验室检查明显异常：①ALT、AST超过正常值上限50％以上。②血肌酐超过正常值上限者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6839"}
{"text": " 3）病理诊断确诊胃癌", "label": 11, "label_text": "Diagnostic", "id": "s6840"}
{"text": " 4. 同时参加其他临床试验。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6841"}
{"text": " 2.  约≥15 个中等大小的玻璃膜疣或出现大玻璃膜疣 3a: 无玻璃膜疣样色素上皮脱离 3b: 有玻璃膜疣样色素上皮脱离", "label": 5, "label_text": "Multiple", "id": "s6842"}
{"text": " a)频繁抽搐、昏迷、脑疝", "label": 4, "label_text": "Disease", "id": "s6843"}
{"text": "1.发生急性鼻窦炎合并鼻腔急性感染的患者。", "label": 4, "label_text": "Disease", "id": "s6844"}
{"text": " 6. 造血系统疾病；", "label": 4, "label_text": "Disease", "id": "s6845"}
{"text": " （2）病情程度属于Ⅳ级COPD稳定期患者；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6846"}
{"text": " （3）患侧直腿抬高试验小于 50° ；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6847"}
{"text": " 2.凝血功能异常", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6848"}
{"text": "1. 1型糖尿病。", "label": 4, "label_text": "Disease", "id": "s6849"}
{"text": " 3.凝血功能异常及其他影响凝血的血液系统疾病者；", "label": 5, "label_text": "Multiple", "id": "s6850"}
{"text": " 4、血友病、严重血小板减少、凝血功能异常者；", "label": 5, "label_text": "Multiple", "id": "s6851"}
{"text": " 6)文盲，听说读写能力障碍者；", "label": 5, "label_text": "Multiple", "id": "s6852"}
{"text": " ④ 年龄18～65周岁，性别不限；", "label": 5, "label_text": "Multiple", "id": "s6853"}
{"text": " 11. 吸毒、长期酗酒以致影响试验结果评价的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s6854"}
{"text": " 3、符合牙本质敏感诊断，研究牙为前牙或前磨牙，发生牙本质敏感部位为颊面牙颈部，引起牙本质敏感的原因为磨损或牙龈退缩；", "label": 30, "label_text": "Oral related", "id": "s6855"}
{"text": " ②合并严重心、肝、肺、肾等躯体疾患者及癌症患者；", "label": 4, "label_text": "Disease", "id": "s6856"}
{"text": " 4、全身或局部感染", "label": 4, "label_text": "Disease", "id": "s6857"}
{"text": " (3) 体重指数〔BMI=体重(kg)/身高(m)2〕在19~24kg/m2范围内。", "label": 9, "label_text": "Risk Assessment", "id": "s6858"}
{"text": " 3. 以吸烟斗作为主要或次要烟草使用方式", "label": 36, "label_text": "Smoking Status", "id": "s6859"}
{"text": "已被诊断为正常眼压性青光眼的患者.", "label": 4, "label_text": "Disease", "id": "s6860"}
{"text": " (4)服用抗凝药或阿司匹林或利血平停药不足1周；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6861"}
{"text": " (15)研究者认可的任何其他不适于参加本研究的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s6862"}
{"text": " 11、入选前1个月内口服糖皮质激素；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6863"}
{"text": " （7）同时伴发其他恶性疾病。", "label": 4, "label_text": "Disease", "id": "s6864"}
{"text": " ②吸烟者设定的戒烟日在未来1个月内；", "label": 36, "label_text": "Smoking Status", "id": "s6865"}
{"text": " 5）妊娠期或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6866"}
{"text": " 9)正在、准备参加或3个月内参加过其他临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6867"}
{"text": "1)性别：男性。", "label": 35, "label_text": "Gender", "id": "s6868"}
{"text": " （3）尿胆红素阳性，尿胆原阴性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6869"}
{"text": " (3) HIV抗体或HCV抗体阳性者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6870"}
{"text": " 2.重大膝关节疾病或畸形", "label": 4, "label_text": "Disease", "id": "s6871"}
{"text": " 2)对方案中任何药物有过敏史。", "label": 7, "label_text": "Allergy Intolerance", "id": "s6872"}
{"text": " 7）处于严重的难以控制的局部或全身急、慢性感染期间；", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s6873"}
{"text": " ② WBC≥3.0×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6874"}
{"text": "1.在参加该研究前的4周内接受过除TACE以外的任何局部治疗（包括但不限于手术、放疗、肝动脉栓塞、肝动脉灌注、射频消融、冷冻消融或经皮乙醇注射）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6875"}
{"text": " 部分患者合并有高血压(Ⅰ～Ⅱ级)、 糖尿病、冠心病等疾病", "label": 4, "label_text": "Disease", "id": "s6876"}
{"text": " 2. 接受器官移植患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s6877"}
{"text": " 4） 血液样本中甘油三酯高于3000mg/dL即33.9mmol/L或胆固醇高于500mg/dL即12.95mmol/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6878"}
{"text": " 3.意识清楚，能配合治疗，MMSE≥24分；", "label": 5, "label_text": "Multiple", "id": "s6879"}
{"text": "1.單側阻塞型中風", "label": 4, "label_text": "Disease", "id": "s6880"}
{"text": "1.不适用于手术治疗的下肢静脉曲张患者", "label": 5, "label_text": "Multiple", "id": "s6881"}
{"text": "①经影像学或组织学确诊的复发、转移乳腺癌或伴有其他癌症的患者；", "label": 11, "label_text": "Diagnostic", "id": "s6882"}
{"text": " 3、年龄在35~75岁。", "label": 3, "label_text": "Age", "id": "s6883"}
{"text": " f)能够理解并提供书面的知情同意。", "label": 13, "label_text": "Consent", "id": "s6884"}
{"text": " ⑤病情危重，难以对穴位埋线治疗的有效性和安全性做出准确评价者。", "label": 5, "label_text": "Multiple", "id": "s6885"}
{"text": " (4)孕妇、哺乳期妇女或有生育要求的育龄妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6886"}
{"text": " 中性粒细胞（ANC）≥1.5×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6887"}
{"text": " I.受试者为小学及以上文化程度，有能力完成方案规定的认知能力测定和其他测试；", "label": 5, "label_text": "Multiple", "id": "s6888"}
{"text": "① 肢体缺如或瘫痪、双眼失明等，不能进行主动肢体运动的患者；", "label": 5, "label_text": "Multiple", "id": "s6889"}
{"text": " 2. 既往存在肝素诱导血小板减少症或过敏", "label": 5, "label_text": "Multiple", "id": "s6890"}
{"text": " （三）心电图改变：以R波为主的2个或2个以上主要导联(Ⅰ、Ⅱ、aVF、V5)的ST-T改变持续4天以上伴动态变化，窦房传导阻滞、房室传导阻滞，完全性右或左束支阻滞，成联律、多形、多源、成对或并行性早搏，非房室结及房室折返引起的异位性心动过速，低电压（新生儿除外）及异常Q波。", "label": 5, "label_text": "Multiple", "id": "s6891"}
{"text": "1.患者合并其他精神障碍者。", "label": 4, "label_text": "Disease", "id": "s6892"}
{"text": "（1）首次接受MECT的抑郁患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6893"}
{"text": " 7、每个靶病变的长度最多可用两个FREEWAY球囊覆盖；", "label": 4, "label_text": "Disease", "id": "s6894"}
{"text": " 6）非肝硬化型门脉高压", "label": 4, "label_text": "Disease", "id": "s6895"}
{"text": " 2.膝部骨关节结核、肿瘤、风湿性关节炎、类风湿性关节炎者；", "label": 4, "label_text": "Disease", "id": "s6896"}
{"text": " （15）已确诊存在非心血管疾病，且该疾病预后较差（如转移性癌）或增加了研究治疗的不良反应风险；", "label": 5, "label_text": "Multiple", "id": "s6897"}
{"text": " （4）过夜1mg-LDDST血皮质醇＞1.8 mg/dL", "label": 5, "label_text": "Multiple", "id": "s6898"}
{"text": " （8）孕妇或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6899"}
{"text": " 3.合并严重或不稳定的躯体疾病者；", "label": 4, "label_text": "Disease", "id": "s6900"}
{"text": " 4）严重的肾及造血系统疾病患者；", "label": 4, "label_text": "Disease", "id": "s6901"}
{"text": " ⑤能够理解并签署研究知情同意书。", "label": 13, "label_text": "Consent", "id": "s6902"}
{"text": " （3）存在充血性心力衰竭、肾功能衰竭者；", "label": 5, "label_text": "Multiple", "id": "s6903"}
{"text": " 3.病理确诊为胃癌；", "label": 11, "label_text": "Diagnostic", "id": "s6904"}
{"text": " ⑥不愿意签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6905"}
{"text": "1. 患有痴呆性疾病或严重的精神性疾病，无法配合实验操作和唾液流量检查和口干症状评估。", "label": 5, "label_text": "Multiple", "id": "s6906"}
{"text": "1 继发性青光眼；", "label": 4, "label_text": "Disease", "id": "s6907"}
{"text": " 5)接受椎管内麻醉/区域阻滞麻醉", "label": 0, "label_text": "Therapy or Surgery", "id": "s6908"}
{"text": " 4）头颅CT所见颅内出血性疾病：脑出血、脑室出血、蛛网膜下腔出血、硬膜下或硬膜外血肿；", "label": 11, "label_text": "Diagnostic", "id": "s6909"}
{"text": " 9.既往对芹菜或恩必普有过敏史者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6910"}
{"text": " 2.年龄15～65岁；", "label": 3, "label_text": "Age", "id": "s6911"}
{"text": "1）自愿参加本项临床研究，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6912"}
{"text": "1、年龄25-75岁", "label": 3, "label_text": "Age", "id": "s6913"}
{"text": "1.经过细胞学以及细胞遗传学检查确定是受者型复发白血病", "label": 11, "label_text": "Diagnostic", "id": "s6914"}
{"text": " ②吸烟或戒烟&lt;2年；", "label": 36, "label_text": "Smoking Status", "id": "s6915"}
{"text": " （7）签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6916"}
{"text": " 15)糖尿病；", "label": 4, "label_text": "Disease", "id": "s6917"}
{"text": "1 既往有心血管病史的患者(如重度充血性心衰，病窦综合征，II或III度房室传导阻滞，房扑或房颤合并有房室旁路通道，已用β受体阻滞剂或洋地黄中毒的病人，QRS增宽(≥0.12秒)的室性心动过速病人)；", "label": 5, "label_text": "Multiple", "id": "s6918"}
{"text": " （4）杂交全主动脉弓置换手术。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6919"}
{"text": "1. 紧张性精神分裂症", "label": 4, "label_text": "Disease", "id": "s6920"}
{"text": " ⑦伴有原发或继发癫痫的患者；", "label": 4, "label_text": "Disease", "id": "s6921"}
{"text": " 5)拒绝签署知情同意书者", "label": 13, "label_text": "Consent", "id": "s6922"}
{"text": " (5)患有精神、神经系统疾病者；", "label": 4, "label_text": "Disease", "id": "s6923"}
{"text": " 6）正在参加其他临床研究", "label": 15, "label_text": "Enrollment in other studies", "id": "s6924"}
{"text": " 3）怀孕的。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6925"}
{"text": " （1）合并胃、十二肠溃疡，胃镜下见粘膜糜烂及渗血，病理检查提示胃粘膜萎缩、肠化或异型增生者。", "label": 5, "label_text": "Multiple", "id": "s6926"}
{"text": " 3、入院前已经接受抗病毒、口服阿片类药物及神经阻滞等治疗，疼痛控制不满意，视觉疼痛模拟评分(VAS）≥4 分；", "label": 5, "label_text": "Multiple", "id": "s6927"}
{"text": "1.年龄0-18岁；", "label": 3, "label_text": "Age", "id": "s6928"}
{"text": " j) 参加本试验前14天内使用维生素或其他保健品者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6929"}
{"text": " 14.依从性差、不能按研究方案完成试验者；", "label": 8, "label_text": "Compliance with Protocol", "id": "s6930"}
{"text": " 3）手术方式为乳腺癌改良根治术，且术后&lt;1年；", "label": 0, "label_text": "Therapy or Surgery", "id": "s6931"}
{"text": " 8）不愿意或无法配合资料收集者；", "label": 13, "label_text": "Consent", "id": "s6932"}
{"text": " 4．影像学诊断为椎间盘完全突出脱垂者；", "label": 11, "label_text": "Diagnostic", "id": "s6933"}
{"text": " 7 签署知情同意书", "label": 13, "label_text": "Consent", "id": "s6934"}
{"text": "1试验前 3个月每日吸烟量多于 5支者；", "label": 36, "label_text": "Smoking Status", "id": "s6935"}
{"text": " 15)已知受试者既往对大分子蛋白制剂/单克隆抗体，或已知对任何试验药物组成成分过敏者；", "label": 5, "label_text": "Multiple", "id": "s6936"}
{"text": " d.临床症状大于3个月，近1个月未用其他治疗方法和影响排尿的药物。", "label": 5, "label_text": "Multiple", "id": "s6937"}
{"text": " 3.8妊娠期、哺乳期妇女或近期有生育计划者。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6938"}
{"text": " （5）合并肝、肾及造血系统等严重原发性疾病，精神病患者", "label": 4, "label_text": "Disease", "id": "s6939"}
{"text": " 5.住院患者", "label": 26, "label_text": "Encounter", "id": "s6940"}
{"text": " （5）受累上肢肌力差；", "label": 1, "label_text": "Sign", "id": "s6941"}
{"text": " （11）近期使用直接凝血酶抑制剂或直接 Xa 因子抑制剂，且相关指标升高", "label": 5, "label_text": "Multiple", "id": "s6942"}
{"text": " 3)患有先天性遗传代谢性疾病；", "label": 4, "label_text": "Disease", "id": "s6943"}
{"text": " *治疗前后未作腹部CT检查。", "label": 12, "label_text": "Laboratory Examinations", "id": "s6944"}
{"text": "1严重腰椎间盘突出，具有手术指征的患者。", "label": 5, "label_text": "Multiple", "id": "s6945"}
{"text": " 7.有明显肠道梗阻、胃肠出血或现阶段腹泻者；", "label": 4, "label_text": "Disease", "id": "s6946"}
{"text": " 5.正在或最近3个月内接受试验药物治疗；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6947"}
{"text": " 3.有肺癌史", "label": 4, "label_text": "Disease", "id": "s6948"}
{"text": " 7）自愿参加本实验并签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s6949"}
{"text": " f. 病人必须被告知本研究的基本内容并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6950"}
{"text": "(1)临床上有显著的变态反应史，特别是药物过敏史，尤其对二甲双胍及辅料中任何成分过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s6951"}
{"text": " 4. 数据大量缺失或不全", "label": 22, "label_text": "Data Accessible", "id": "s6952"}
{"text": "远处转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s6953"}
{"text": "(1) 符合感染后咳嗽的诊断；", "label": 11, "label_text": "Diagnostic", "id": "s6954"}
{"text": " ? 患者伴不稳定性心绞痛、急性心梗、近3月内接受CABG或PCI术.", "label": 5, "label_text": "Multiple", "id": "s6955"}
{"text": " 4、慢性高血压并发子痫前期： 慢性高血压孕妇妊娠前无蛋白尿， 妊娠后出现蛋白尿≧0.3g/24小时； 或妊娠前有蛋白尿， 妊娠后蛋白尿明显增加或血压进一步升高或出现血小板减少&lt;100×109/L.", "label": 5, "label_text": "Multiple", "id": "s6956"}
{"text": " （3）能签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s6957"}
{"text": " ⑻签署知情同意书，自愿参与本试验", "label": 13, "label_text": "Consent", "id": "s6958"}
{"text": " 15.在试验前3个月内献血超过200 mL，或在试验期间、试验结束后1个月内计划献血者", "label": 14, "label_text": "Blood Donation", "id": "s6959"}
{"text": " 3.术前肝功Child A或B级；", "label": 9, "label_text": "Risk Assessment", "id": "s6960"}
{"text": " 6）预计生存期超过3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s6961"}
{"text": "（1）符合糖尿病足诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s6962"}
{"text": "1. 临床确诊慢性闭角型青光眼；", "label": 4, "label_text": "Disease", "id": "s6963"}
{"text": " （3）精神正常并能遵守试验协议的程序；", "label": 5, "label_text": "Multiple", "id": "s6964"}
{"text": " - 受试者在过去的2个月内无免疫球蛋白接种史/2月龄婴儿出生后无免疫球蛋白接种史，接种前14天内无其他活疫苗接种史，7天内无其他灭活疫苗接种史；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6965"}
{"text": "1. 正在参加其他的药物或行为学临床研究，或参与其他锻炼计划；", "label": 15, "label_text": "Enrollment in other studies", "id": "s6966"}
{"text": " 4) 签署知情同意，同意参加本项研究。", "label": 13, "label_text": "Consent", "id": "s6967"}
{"text": " 1．妊娠女性或哺乳期女性患者，或计划在研究期间妊娠或哺乳的女性患者。在研究期间不能保证使用可靠的避孕措施的所有生育年龄的女性患者", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6968"}
{"text": " （7）药物史：1周内应用激素类药物、影响胃排空的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6969"}
{"text": " 2.病程≥3个月。", "label": 4, "label_text": "Disease", "id": "s6970"}
{"text": " 2.成年汉族人", "label": 31, "label_text": "Ethnicity", "id": "s6971"}
{"text": " 15.育龄妇女但未采取合理的避孕措施或妊娠试验阳性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6972"}
{"text": " ⑦二维心脏彩超测得LVEF≥45%；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6973"}
{"text": " 1.患有严重疾病，如晚期肿瘤、慢性阻塞性肺病急性发作期、急性或渐进性肝病或肾病、充血性心力衰竭等；", "label": 4, "label_text": "Disease", "id": "s6974"}
{"text": " （6）签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s6975"}
{"text": " 4.血肌酐超过正常范围上限者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s6976"}
{"text": " 3.年龄在18-75岁之间者；", "label": 3, "label_text": "Age", "id": "s6977"}
{"text": " 3.使用免疫抑制剂的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6978"}
{"text": " 3）年龄≥1岁，且&lt;70岁", "label": 3, "label_text": "Age", "id": "s6979"}
{"text": "IBS患者纳入标准：", "label": 4, "label_text": "Disease", "id": "s6980"}
{"text": " 1、孕妇、准备妊娠或哺乳期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6981"}
{"text": " ?不配合无法沟通者", "label": 25, "label_text": "Literacy", "id": "s6982"}
{"text": "1）对贝那鲁肽、西格列汀，或任一组分过敏或有使用禁忌症者或不耐受者", "label": 7, "label_text": "Allergy Intolerance", "id": "s6983"}
{"text": " 8.在18个月内计划做移植的患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s6984"}
{"text": " 7. 肾功能衰竭需立即进行透析者。", "label": 5, "label_text": "Multiple", "id": "s6985"}
{"text": " 2) 妊娠中及试验期间中希望妊娠的妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s6986"}
{"text": "(1)糖尿病性黄斑水肿；", "label": 4, "label_text": "Disease", "id": "s6987"}
{"text": " 6.患者对妊娠有明确影响的疾病的患者，如高血压、有临床症状的心脏病、糖尿病、肝脏疾病、肾脏疾病、重度贫血、静脉血栓史、肺栓塞或脑血管事件史、恶性肿瘤病史", "label": 5, "label_text": "Multiple", "id": "s6988"}
{"text": " (4)有严重的其它系统疾病和脏器功能不全者。", "label": 5, "label_text": "Multiple", "id": "s6989"}
{"text": "1.获得知情同意书；", "label": 13, "label_text": "Consent", "id": "s6990"}
{"text": " 6、排除痴呆患者，不能配合的兴奋冲动患者。", "label": 17, "label_text": "Capacity", "id": "s6991"}
{"text": "（1）经病理学或细胞学诊断确诊为非小细胞肺癌，组织及血液标本基因检测驱动基因阴性，基因检测包括EGFR/ALK/ROS1/MET/HER2/PIK3CA/BRAF/RET/Key等；", "label": 5, "label_text": "Multiple", "id": "s6992"}
{"text": " 5、服用阿司匹林&gt;150mg/d的受试者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s6993"}
{"text": " ?肝功能：", "label": 6, "label_text": "Organ or Tissue Status", "id": "s6994"}
{"text": " （9）不能坚持治疗者。", "label": 17, "label_text": "Capacity", "id": "s6995"}
{"text": " 13) 正参加其它临床研究的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6996"}
{"text": " 2、股骨颈骨折或髋关节骨性关节炎，行全髋置换或股骨头者；", "label": 5, "label_text": "Multiple", "id": "s6997"}
{"text": " 6.癫痫症病史者；", "label": 4, "label_text": "Disease", "id": "s6998"}
{"text": " ⑻ 两周以内参加影响本研究结果评价的其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s6999"}
{"text": "（1）青光眼、精神病、前列腺增生、脑出血急性期患者。", "label": 4, "label_text": "Disease", "id": "s7000"}
{"text": " d. 所有受试者均知情并同意参加该项研究。", "label": 13, "label_text": "Consent", "id": "s7001"}
{"text": " 2. 根据2016年美国重症医学会（SCCM）与欧洲重症医学会（ESICM）联合发布脓毒症3.0定义以及诊断标准符合脓毒症诊断标准（SOFA评分&gt;=2）；", "label": 11, "label_text": "Diagnostic", "id": "s7002"}
{"text": " ③患者及其法定监护人签署知情同意。", "label": 13, "label_text": "Consent", "id": "s7003"}
{"text": " 6. 身体内有金属物品（如骨固定钢板、节育环等）；", "label": 34, "label_text": "Device", "id": "s7004"}
{"text": "① 既往有肺内靶病灶外照射治疗史或其他内照射治疗史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7005"}
{"text": " 6 既往接受抗病毒、抗肿瘤等治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7006"}
{"text": "1.女性患者处于妊娠期、哺乳期或在试验期间计划妊娠", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7007"}
{"text": " 患者腿部溃疡按照Wagners分期应在1-3期", "label": 20, "label_text": "Non-Neoplasm Disease Stage", "id": "s7008"}
{"text": "①符合室性早搏Lown2-4A级；", "label": 9, "label_text": "Risk Assessment", "id": "s7009"}
{"text": " 13. 预期寿命≤12个月；", "label": 23, "label_text": "Life Expectancy", "id": "s7010"}
{"text": " 9. 未控制的重症感染者，或其他严重的伴随疾病者。", "label": 4, "label_text": "Disease", "id": "s7011"}
{"text": " （2）KPS评分&gt;60分，估计生存期&gt;3个月；", "label": 5, "label_text": "Multiple", "id": "s7012"}
{"text": " d.脓毒性休克不一定要存在低血压，但疑有感染患儿出现低血压一定是脓毒性休克。", "label": 5, "label_text": "Multiple", "id": "s7013"}
{"text": " (3)B超、全胸正侧位片、全身骨扫描或PET-CT检查未发现远处转移者。", "label": 11, "label_text": "Diagnostic", "id": "s7014"}
{"text": " ③术后病理证实为转移性肝癌者；", "label": 11, "label_text": "Diagnostic", "id": "s7015"}
{"text": " （4）左室整体收缩功能低下（LVEF≤50％）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7016"}
{"text": " （11）有晕针或晕血史；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s7017"}
{"text": " 3.有托吡酯或丙戊酸禁忌症患者", "label": 4, "label_text": "Disease", "id": "s7018"}
{"text": "1)影像设备（CT、DSA、磁共振等）检查禁忌症患者；", "label": 11, "label_text": "Diagnostic", "id": "s7019"}
{"text": " 2.患者有其他雄激素过多相关疾病（包括21羟化酶缺乏的先天性肾上腺皮质增 生，分泌雄激素的肿瘤，过多使用产生雄激素的药物，库欣综合症，重度胰岛素抵抗，甲状腺功能障碍及高泌乳素血症）", "label": 5, "label_text": "Multiple", "id": "s7020"}
{"text": " （5）Hachinski缺血指数评分&lt;4；", "label": 9, "label_text": "Risk Assessment", "id": "s7021"}
{"text": " （3）近一个月内完善胃镜及病理检查者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7022"}
{"text": "1)择期下腹部手术或下肢手术，", "label": 0, "label_text": "Therapy or Surgery", "id": "s7023"}
{"text": " 6.月经周期提前超过10天者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7024"}
{"text": " 3. 拟择期行剖宫产术", "label": 0, "label_text": "Therapy or Surgery", "id": "s7025"}
{"text": " 9、对酒石酸托特罗定片过敏者的患者", "label": 7, "label_text": "Allergy Intolerance", "id": "s7026"}
{"text": " 5、患有慢性消耗性疾病，如肿瘤等；", "label": 4, "label_text": "Disease", "id": "s7027"}
{"text": " 5、荧光素钠过敏者", "label": 7, "label_text": "Allergy Intolerance", "id": "s7028"}
{"text": " 4.术前Hb、PLT、PT、INR和APTT达到手术指征者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7029"}
{"text": " 3.超出UCSF标准的原发性肝癌", "label": 4, "label_text": "Disease", "id": "s7030"}
{"text": " 2.合并心肌病、瓣膜病、先天性心脏病、各种原因左心功能不全", "label": 5, "label_text": "Multiple", "id": "s7031"}
{"text": " （2）经急诊去骨瓣减压或颅内血肿清除术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7032"}
{"text": "（1）近1个月服用抑酸类或抗生素类药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7033"}
{"text": "1）不孕夫妻除外单侧卵巢巧克力囊肿外还发现其它明显的不孕原因，例如：排卵障碍、严重少弱畸精症、双侧输卵管堵塞、宫颈因素不孕、性交障碍等", "label": 4, "label_text": "Disease", "id": "s7034"}
{"text": " 7.签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7035"}
{"text": " 7、肠梗阻、肠出血、严重吸收不良、严重的短肠症或者高排泄量的瘘、严重恶心呕吐", "label": 5, "label_text": "Multiple", "id": "s7036"}
{"text": "1、年龄处于18-60岁之间，肾移植术后至少一年、靠免疫抑制剂可有效维持移植肾功能、病情稳定的患者；", "label": 5, "label_text": "Multiple", "id": "s7037"}
{"text": " （6）未能完成12个月临床、冠状动脉造影及IMR随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7038"}
{"text": " d.患侧腕关节伸展&gt;20°，拇指和其余四指中两指的掌指关节和指间关节伸展&gt;10°，且动作在1 min内可重复3次；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7039"}
{"text": " （8）排除由酒精或咖啡、浓茶等生活因素所致的睡眠障碍者；", "label": 4, "label_text": "Disease", "id": "s7040"}
{"text": " 4、中性粒细胞&lt;2.0×109˙L-1", "label": 12, "label_text": "Laboratory Examinations", "id": "s7041"}
{"text": "1.妊娠或哺乳妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7042"}
{"text": "连续入住ICU成年患者；", "label": 26, "label_text": "Encounter", "id": "s7043"}
{"text": " （4）合并有严重心衰、肺、肝、肾、造血系统和内分泌系统等严重原发性疾病、恶性肿瘤、消化道出血、胃溃疡及有出血倾向等预计不能完成试验者；", "label": 4, "label_text": "Disease", "id": "s7044"}
{"text": " (4)签署书面知情同意书", "label": 13, "label_text": "Consent", "id": "s7045"}
{"text": " 5）在针刺穴位周围有皮肤感染等情况；", "label": 4, "label_text": "Disease", "id": "s7046"}
{"text": " 4.有明显皮肤破损或感染者。", "label": 4, "label_text": "Disease", "id": "s7047"}
{"text": " 5.无酸碱平衡失调或电解质紊乱", "label": 1, "label_text": "Sign", "id": "s7048"}
{"text": " （2）生化检查需符合以下标准：Crea和BIL ≤ 1.0倍正常值上限（ULN），ALT和AST≤ 2.5倍正常值上限（ULN）", "label": 12, "label_text": "Laboratory Examinations", "id": "s7049"}
{"text": " 2) 已知对MMF、环磷酰胺、糖皮质激素过敏或有禁忌症", "label": 7, "label_text": "Allergy Intolerance", "id": "s7050"}
{"text": " 6、需要行冠脉旁路移植术（心脏搭桥术）患者。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7051"}
{"text": " （2） 胃镜检查符合RE（A/B级）或无食管粘膜损伤（洛杉矶分类标准） 但有典型的反流、烧心、胸骨后疼痛等症状，且病程≥2个月，GERD-Q量表评分≥8分", "label": 5, "label_text": "Multiple", "id": "s7052"}
{"text": " 9)食管支架置入术后；", "label": 34, "label_text": "Device", "id": "s7053"}
{"text": " 13.研究者认为不适宜参加本试验", "label": 21, "label_text": "Researcher Decision", "id": "s7054"}
{"text": "①符合房颤的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7055"}
{"text": " （2）输卵管造影发现输卵管积水及闭锁；", "label": 11, "label_text": "Diagnostic", "id": "s7056"}
{"text": "(1)服用止痛药＞10天/月者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7057"}
{"text": " 5.全身应用可能损害视神经的药物。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7058"}
{"text": " 4、手术均由我科同一组医师实施;", "label": 0, "label_text": "Therapy or Surgery", "id": "s7059"}
{"text": " 6.系统性免疫疾病", "label": 4, "label_text": "Disease", "id": "s7060"}
{"text": " 20. 过去2年内存在导致末端器官损伤或需要全身免疫抑制/全身疾病调节药物的自身免疫性疾病（如，克罗恩氏病、类风湿性关节炎、系统性红斑狼疮）病史；", "label": 5, "label_text": "Multiple", "id": "s7061"}
{"text": " 2.恶性肿瘤正在接受治疗且预期寿命&lt;2年（由研究组医师判断）", "label": 5, "label_text": "Multiple", "id": "s7062"}
{"text": " 2. 拟行开胸心内直视手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7063"}
{"text": "1.年龄在2岁至65岁（含2岁及65岁）", "label": 3, "label_text": "Age", "id": "s7064"}
{"text": "1. 1994年至2015年在参与单位住院及随访的甲状腺癌患者资料；", "label": 22, "label_text": "Data Accessible", "id": "s7065"}
{"text": " （9）有发热性疾病，无法控制症状者；", "label": 4, "label_text": "Disease", "id": "s7066"}
{"text": " 4．使用肝素或华法令抗凝存在绝对禁忌症", "label": 5, "label_text": "Multiple", "id": "s7067"}
{"text": " 3，哺乳及妊娠期妇女", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7068"}
{"text": "1、同意参加该临床研究的患者；", "label": 13, "label_text": "Consent", "id": "s7069"}
{"text": "（1）已明确证实的继发性高血压；", "label": 4, "label_text": "Disease", "id": "s7070"}
{"text": " f、晕灸者或对艾灸排斥者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7071"}
{"text": " 5.食管或胃底静脉曲张,卓-艾氏综合症,有严重并发症，如幽门梗阻、内镜下活动出血者；幽门狭窄阻碍内镜通过；食管糜烂或溃疡，有消化道其他严重疾病,如克罗恩病、溃疡性结肠炎等；", "label": 4, "label_text": "Disease", "id": "s7072"}
{"text": " （3）存在急性心衰、严重肝、肾功能不全的患者，或伴有严重消耗性疾病、凝血功能异常的患者。", "label": 5, "label_text": "Multiple", "id": "s7073"}
{"text": "a.妊娠期或产后八周内的女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7074"}
{"text": " （10）在过去7天内曾有急性疾病、需要全身应用抗生素或抗病毒治疗的感染者；", "label": 5, "label_text": "Multiple", "id": "s7075"}
{"text": " 最近3个月用过药物治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s7076"}
{"text": " 既往无明确外伤史", "label": 4, "label_text": "Disease", "id": "s7077"}
{"text": " ④意识障碍或认知功能障碍影响问卷真实性者", "label": 4, "label_text": "Disease", "id": "s7078"}
{"text": " （二）槟榔颗粒对妇科术后患者胃肠功能的作用：1）妇科术后患者40~75岁；2）胃肠外科：40-80岁之间；3）手术时间：手术时间为0.5-5小时者；4）麻醉时间：1.0-6.5小时者；5）中医证型属于气虚气滞，腑气不通者；6）知情同意者。", "label": 5, "label_text": "Multiple", "id": "s7079"}
{"text": " 8. 试验前签署书面知情同意书。", "label": 13, "label_text": "Consent", "id": "s7080"}
{"text": " 4. 签署知情同意书，志愿受试。", "label": 13, "label_text": "Consent", "id": "s7081"}
{"text": " （3）年龄18-80岁；", "label": 3, "label_text": "Age", "id": "s7082"}
{"text": " ③接受新辅助化疗的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7083"}
{"text": " （3）预计接受治疗方案含大剂量激素。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7084"}
{"text": " 11.不同意签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7085"}
{"text": " 3．手腕手术史;", "label": 0, "label_text": "Therapy or Surgery", "id": "s7086"}
{"text": " 2.患有其他眼底病变。", "label": 4, "label_text": "Disease", "id": "s7087"}
{"text": " 2.同时入组于另一项临床研究，除非是观察性(非干预性)临床研究或是干预性研究的随访阶段。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7088"}
{"text": " 5、受试者自愿并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7089"}
{"text": " ⑤任何影响治疗的状态 (比如Fitzpatrick皮肤分型VI)", "label": 9, "label_text": "Risk Assessment", "id": "s7090"}
{"text": " （3）术后经病理学确诊的复发性肝细胞癌患者；", "label": 11, "label_text": "Diagnostic", "id": "s7091"}
{"text": " 3、ASA分级I-II级患者", "label": 9, "label_text": "Risk Assessment", "id": "s7092"}
{"text": " b)且抑酸治疗有效但需长期服药；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7093"}
{"text": " 4. 空腹血清LDL-C &gt; 3.37mmol/L（130mg/dl）。", "label": 12, "label_text": "Laboratory Examinations", "id": "s7094"}
{"text": " 9.心力衰竭（纽约心功能分级 III-IV 级），或 EF 小于等于 30%。", "label": 5, "label_text": "Multiple", "id": "s7095"}
{"text": " 2、有两种或者两种以上的神经症状(头痛、癫痫、恶心、呕吐、意识改变、畏光症或局灶性神经缺损) ；", "label": 28, "label_text": "Symptom", "id": "s7096"}
{"text": "1.受试者在筛选前28天内接受试验治疗(或5个半衰期，以较长者为准)。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7097"}
{"text": " 3.糖尿病严重并发症;", "label": 4, "label_text": "Disease", "id": "s7098"}
{"text": " (5)对核苷（酸）类似物，尤其恩替卡韦过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7099"}
{"text": " 7.其他不适合放置食管气囊导管患者。", "label": 34, "label_text": "Device", "id": "s7100"}
{"text": "1）严重的心脑血管疾病、呼吸衰竭、精神障碍", "label": 4, "label_text": "Disease", "id": "s7101"}
{"text": " 7)有神经病变或精神障碍以致不能理解知情同意书或配合研究的患者；", "label": 5, "label_text": "Multiple", "id": "s7102"}
{"text": "颈椎骨折部分：经CT及MR证实的急性寰椎骨折、寰枢椎复合型骨折，下颈椎骨折、脱位、韧带损伤伴脱位，年龄18岁以上，在创伤后急性期接受了非手术治疗；随访超过两年。", "label": 5, "label_text": "Multiple", "id": "s7103"}
{"text": " ②适合行冠状动脉支架术，包括急性ST段抬高心肌梗死（STEMI）、不稳定心绞痛（UA）和非ST段抬高心肌梗死（NSTEMI）；", "label": 5, "label_text": "Multiple", "id": "s7104"}
{"text": " ⑤ 患者同意，自愿签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7105"}
{"text": " (7)固视良好，能配合Sirius检查及电脑验光；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7106"}
{"text": " 2.发病72小时内，符合急性缺血性脑卒中的TOAST分型标准，并经神经影像学检查证实；", "label": 11, "label_text": "Diagnostic", "id": "s7107"}
{"text": " 2、冠脉造影显示冠脉及主要分支有一处以上≥50%的狭窄且植入药物洗脱支架（DES）", "label": 11, "label_text": "Diagnostic", "id": "s7108"}
{"text": " 2. 年龄18-65岁之间；", "label": 3, "label_text": "Age", "id": "s7109"}
{"text": " （5）长期透析患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7110"}
{"text": " 4.患处并发有其他明显的可能会影响到疗效评价的其它疾病者。", "label": 4, "label_text": "Disease", "id": "s7111"}
{"text": " 2.正常对照者需无打鼾及睡眠呼吸暂停的病史；", "label": 4, "label_text": "Disease", "id": "s7112"}
{"text": " 4）该患者的主管医师必须愿意完成并提交完整的病例报告表。", "label": 13, "label_text": "Consent", "id": "s7113"}
{"text": " ②HP RUT和W-S染色双阳性", "label": 12, "label_text": "Laboratory Examinations", "id": "s7114"}
{"text": "   能够依从研究方案和随访流程；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7115"}
{"text": " 3.正在服用抗凝药物如阿司匹林、华法林、达比加群、里瓦沙班、阿哌沙班等未停药2周以上的；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7116"}
{"text": "1.有任何疫苗接种或药物严重过敏史，既往接种预防用生物制品出现发热39℃以上；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7117"}
{"text": " 12.有肠内营养禁忌症受试者；", "label": 4, "label_text": "Disease", "id": "s7118"}
{"text": "1.其他原因引起的认知功能减退：脑血管病、中枢神经系统感染、克-雅病、亨廷顿舞蹈症和帕金森病、路易体痴呆、脑外伤性痴呆、其他理化因素（药物、酒精、CO等）、重要躯体疾病（肝性脑病、肺性脑病等）、颅内占位性病变（硬膜下血肿、脑肿瘤）、内分泌系统病变（甲状腺疾病、甲状旁腺疾病）以及维生素或其他任何原因引起的痴呆；", "label": 4, "label_text": "Disease", "id": "s7119"}
{"text": " （4）实验近期(3个月内)无持续性剧烈疼痛，女性者非月经期，妊娠试验阴性;", "label": 5, "label_text": "Multiple", "id": "s7120"}
{"text": " 5)既往使用 PDE5-i 有效者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7121"}
{"text": " - 患者有严重的交流障碍（如失语、痴呆等）或其他影响疗效评估的疾病；", "label": 4, "label_text": "Disease", "id": "s7122"}
{"text": " 5. 供受体ABO血型不合；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7123"}
{"text": "①妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7124"}
{"text": " 8.白细胞计数＜4.0×109/L，血小板计数＜100×109/L，血红蛋白＜90g/L，或伴有其他血液系统疾病者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7125"}
{"text": " 7.ECOG 行为状态评分 0～1。", "label": 9, "label_text": "Risk Assessment", "id": "s7126"}
{"text": " 4、其他全身麻醉和腹腔镜手术禁忌症者", "label": 4, "label_text": "Disease", "id": "s7127"}
{"text": "①有活动性消化出血,或既往曾复发溃疡、出血者；", "label": 5, "label_text": "Multiple", "id": "s7128"}
{"text": " 5.合并其他器官/系统肿瘤。", "label": 4, "label_text": "Disease", "id": "s7129"}
{"text": " b)急性无痛性视力下降；", "label": 4, "label_text": "Disease", "id": "s7130"}
{"text": " 4.患心、肝、肾等重大躯体疾病不能耐受本研究；", "label": 4, "label_text": "Disease", "id": "s7131"}
{"text": " （5）4周内未使用过抗生素、铋剂、益生菌制剂、H2受体拮抗剂和PPI制剂者。", "label": 5, "label_text": "Multiple", "id": "s7132"}
{"text": " 4）受试者（包括男性受试者）愿意未来6个月内无妊娠计划且自愿采取有效避孕措施；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7133"}
{"text": " ②年龄≧18岁；", "label": 3, "label_text": "Age", "id": "s7134"}
{"text": " 9.正在接受试验性药物或仪器试验", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7135"}
{"text": " 14. 正接受免疫抑制治疗(除了间断的、低剂量的皮质类固醇治疗);", "label": 0, "label_text": "Therapy or Surgery", "id": "s7136"}
{"text": "1)18≤年龄≤80；", "label": 3, "label_text": "Age", "id": "s7137"}
{"text": "患者生化指标在正常范围值内；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7138"}
{"text": "  4.可有脑/脑膜转移史，如有症状须经过局部治疗（手术和/或放疗），且无进一步针对脑/脑膜转移病灶的治疗计划。", "label": 5, "label_text": "Multiple", "id": "s7139"}
{"text": " （3）无明显的玻璃体视网膜增生（PVR A-B级）；", "label": 4, "label_text": "Disease", "id": "s7140"}
{"text": " （11）精神病患者，或认知功能障碍。", "label": 4, "label_text": "Disease", "id": "s7141"}
{"text": " 3.皮肤点刺实验红色毛癣菌，须癣毛癣菌，絮状表皮癣菌至少有一种阳性;", "label": 4, "label_text": "Disease", "id": "s7142"}
{"text": " 3. 脑转移；", "label": 4, "label_text": "Disease", "id": "s7143"}
{"text": " 慢性完全闭塞性病变（术前TIMI 0级血流）；", "label": 4, "label_text": "Disease", "id": "s7144"}
{"text": " 5.首次非晚期（CCR&lt;36月）骨髓复发且无合适供体（非亲源性异基因供体）；", "label": 5, "label_text": "Multiple", "id": "s7145"}
{"text": " 5. 能配合定期接受术前及术后检查和随访；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7146"}
{"text": " 10.经研究者判断，患者存在其他不适宜入组情况", "label": 21, "label_text": "Researcher Decision", "id": "s7147"}
{"text": "1.年龄18岁及以上。", "label": 3, "label_text": "Age", "id": "s7148"}
{"text": " （2）单纯的上呼吸道感染；", "label": 4, "label_text": "Disease", "id": "s7149"}
{"text": " ② 符合2004 年西安粘连性中耳炎诊断标准，患者传导性听力下降伴耳闷和（或）耳鸣，体格检查、纯音测听、声阻抗及颞骨高分辨CT 检查结果支持粘连性中耳炎的诊断；", "label": 5, "label_text": "Multiple", "id": "s7150"}
{"text": " 4 WBC＜2×10^9/L，N＜1.0×10^9/L，Hb＜90g/L，PLT＜75×10^9/L，肝、肾功能不全（AST、ALT、T-BIL≥参考值上限2倍或肌酐检测值≥参考值上限2倍）者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7151"}
{"text": " 6、受试者经过基础治疗后病情稳定1个月以上，先心病患者经介入或手术封堵治疗≥6个月；", "label": 5, "label_text": "Multiple", "id": "s7152"}
{"text": " 2.所有患者均有可评价的病灶；", "label": 4, "label_text": "Disease", "id": "s7153"}
{"text": " 4)入选前4周检查血hsCRP＞15mg/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7154"}
{"text": " (3) 严重、未控制的内科疾患如糖尿病、高血压，心脏病、慢性活动迁延性病毒性肝炎。", "label": 4, "label_text": "Disease", "id": "s7155"}
{"text": " 2.胰十二指肠择期手术患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7156"}
{"text": " 11）不同意填写知情同意书者", "label": 13, "label_text": "Consent", "id": "s7157"}
{"text": "1. 无法或拒绝采集肿瘤样本，包括肿瘤组织块，或恶性胸水，或循环肿瘤细胞等；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7158"}
{"text": " 6 严重的心血管疾病；", "label": 4, "label_text": "Disease", "id": "s7159"}
{"text": "1.对亚胺培南/西司他丁或美罗培南过敏的患者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s7160"}
{"text": " c)未经其它骨质疏松类药物治疗或者其它骨质疏松药停用12周以上；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7161"}
{"text": " ②存在气腹禁忌证（如严重心肺功能不全者）；", "label": 4, "label_text": "Disease", "id": "s7162"}
{"text": "   2）放射学检查肺部有病灶。", "label": 11, "label_text": "Diagnostic", "id": "s7163"}
{"text": " 3）卡氏评分（Karnofsky）≥60分；", "label": 9, "label_text": "Risk Assessment", "id": "s7164"}
{"text": " 4．处于怀孕期或哺乳期的女性患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7165"}
{"text": " 6. 签署知情同意书，志愿受试，获得知情同意书过程应符合GCP规定。", "label": 13, "label_text": "Consent", "id": "s7166"}
{"text": " 5）经检验证实咽部症状由鼻咽、喉咽、喉、食管、气管、颈部及全身其他隐匿性疾病所致者；", "label": 4, "label_text": "Disease", "id": "s7167"}
{"text": " （4）病理检查为非小细胞肺癌。", "label": 11, "label_text": "Diagnostic", "id": "s7168"}
{"text": " 7)椎体压缩程度超过75％，预计无穿刺入路的患者；", "label": 1, "label_text": "Sign", "id": "s7169"}
{"text": " 4.目前正在应用激素或免疫抑制剂的患者（以下标准中符合任意1项即可）：", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7170"}
{"text": "   1、18-65周岁；", "label": 3, "label_text": "Age", "id": "s7171"}
{"text": " Ⅲ.年龄18～60岁，右利手，初中以上文化程度；", "label": 5, "label_text": "Multiple", "id": "s7172"}
{"text": "1）男性，≥18岁", "label": 5, "label_text": "Multiple", "id": "s7173"}
{"text": " 理解障碍（无法理解疼痛评定方法）", "label": 17, "label_text": "Capacity", "id": "s7174"}
{"text": " 2.全身性疾病影响到辅具的使用或康复的实施", "label": 5, "label_text": "Multiple", "id": "s7175"}
{"text": " 1.2 预期生存时间大于3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s7176"}
{"text": " 4.3严重的肝肾疾病", "label": 4, "label_text": "Disease", "id": "s7177"}
{"text": "①需要冬眠合剂等持续镇静", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7178"}
{"text": " (7) 研究者认为不适宜参加临床试验者。", "label": 21, "label_text": "Researcher Decision", "id": "s7179"}
{"text": " （2）肿瘤患者（如乳腺癌、霍奇金淋巴瘤、子宫内膜癌、宫颈癌、白血病等）；", "label": 4, "label_text": "Disease", "id": "s7180"}
{"text": " 在进行各个相关研究步骤前，自愿签署由研究审核委员会/独立伦理委员会批准的知情同意书，并注明签署日期。", "label": 5, "label_text": "Multiple", "id": "s7181"}
{"text": " ②6-磷酸-葡萄糖脱氢酶缺乏症（蚕豆病）患者；", "label": 4, "label_text": "Disease", "id": "s7182"}
{"text": " 10)试验前3个月内有献血史，近3个月参与其他药物或器械临床试验者；", "label": 5, "label_text": "Multiple", "id": "s7183"}
{"text": " 5)患者自愿参加研究并接受随访，并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7184"}
{"text": " 3）首次接受上消化道内镜检查；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7185"}
{"text": "1.哺乳、妊娠或正准备妊娠的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7186"}
{"text": "1.骨关节炎患者", "label": 4, "label_text": "Disease", "id": "s7187"}
{"text": " ③病程小于等于2年；", "label": 4, "label_text": "Disease", "id": "s7188"}
{"text": "1.血浆白蛋白 &lt; 20 g/L的患者", "label": 12, "label_text": "Laboratory Examinations", "id": "s7189"}
{"text": " ⑵不能按要求定期随访评估者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s7190"}
{"text": " 8.合并非恶性肿瘤的严重疾病，将影响患者的依从性或使患者处于危险状态；", "label": 5, "label_text": "Multiple", "id": "s7191"}
{"text": " 2）、年龄60~85岁；", "label": 3, "label_text": "Age", "id": "s7192"}
{"text": " 6.患者既往有眼部手术史", "label": 0, "label_text": "Therapy or Surgery", "id": "s7193"}
{"text": " 4）单独的脑膜转移", "label": 4, "label_text": "Disease", "id": "s7194"}
{"text": "年龄 25~55岁", "label": 3, "label_text": "Age", "id": "s7195"}
{"text": " （7）既往已经存在严重的动脉粥样斑块硬化病史；", "label": 4, "label_text": "Disease", "id": "s7196"}
{"text": " 3．卵巢早衰患者;高泌乳素血症，卵巢肿瘤；子宫畸形（双子宫，纵膈子宫等）；复发性流产史（3或3次以上的自然流产）", "label": 4, "label_text": "Disease", "id": "s7197"}
{"text": " 2. 年龄在18～45岁之间，有过性生活的女性。", "label": 5, "label_text": "Multiple", "id": "s7198"}
{"text": " ⑨6个月内发生过糖尿病酮症病史者，", "label": 4, "label_text": "Disease", "id": "s7199"}
{"text": " 6)既往有腹部手术史（腹腔镜胆囊切除、腹腔镜阑尾切除、剖腹产及妇科良性疾病手术史除外）；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7200"}
{"text": "1.年龄在18 周岁以上，65 周岁以下（含65 周岁），性别不限；", "label": 5, "label_text": "Multiple", "id": "s7201"}
{"text": " 4.患者年龄＜18岁。", "label": 3, "label_text": "Age", "id": "s7202"}
{"text": " 3.恶性肿瘤、心肺肝肾等脏器功能不全、内分泌和代谢疾病、血液系统疾病、消化性溃疡；", "label": 5, "label_text": "Multiple", "id": "s7203"}
{"text": " a）消化性溃疡或吸收不良综合征者；", "label": 4, "label_text": "Disease", "id": "s7204"}
{"text": " 4.试验期间不能避免饮酒的患者。", "label": 39, "label_text": "Alcohol Consumer", "id": "s7205"}
{"text": " ④ 半年内参加过其他药物及替代疗法课题；", "label": 15, "label_text": "Enrollment in other studies", "id": "s7206"}
{"text": "1.妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7207"}
{"text": " 8.正在参加其他药物临床研究的受试者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7208"}
{"text": "患者的诊断基于1995年中国医疗协会制定的脑血管疾病诊断诊断要点，纳入标准如下：", "label": 11, "label_text": "Diagnostic", "id": "s7209"}
{"text": " 7. 能理解本研究的情况并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7210"}
{"text": " 3. 有免疫系统类其他疾病者；", "label": 4, "label_text": "Disease", "id": "s7211"}
{"text": " 酗酒者；", "label": 2, "label_text": "Addictive Behavior", "id": "s7212"}
{"text": "(1)继发性高血压、糖尿病史、痛风史", "label": 4, "label_text": "Disease", "id": "s7213"}
{"text": " ③合并药物性肝损害或自身免疫性肝病者；", "label": 4, "label_text": "Disease", "id": "s7214"}
{"text": " 3.既往进行过肝移植的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7215"}
{"text": "(1)3个月内参加过其它临床试验者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s7216"}
{"text": " 7患者依从性好，能理解本研究的情况并签署知情同意书。", "label": 5, "label_text": "Multiple", "id": "s7217"}
{"text": "（1）不具备法律能力或法律能力受限制；", "label": 17, "label_text": "Capacity", "id": "s7218"}
{"text": " 7.良好的肝功能：胆红素&lt;1.5xUNL， AST/ALT &lt; 3 x UNL，碱性磷酸酶&lt; 3 x UNL （除无肝脏疾病有骨转移的情况下）", "label": 5, "label_text": "Multiple", "id": "s7219"}
{"text": " 3. 存在严重的心理或精神异常，估计患者参加本临床研究的依从性较差，预计病变无法获得明确诊断。", "label": 5, "label_text": "Multiple", "id": "s7220"}
{"text": "1.年龄40-80岁；", "label": 3, "label_text": "Age", "id": "s7221"}
{"text": " 3，存在以下合并症，包括糖尿病，活动性乙肝（ALT超过上限，HBsAg+），活动性丙肝（ALT超过上限，HCV抗体+），过敏性紫癜，确诊或疑诊为狼疮性肾炎，系统性血管炎或其他系统性自身免疫性疾病，多发性骨髓瘤等；", "label": 5, "label_text": "Multiple", "id": "s7222"}
{"text": " 5、术前声嘶、咽疼", "label": 28, "label_text": "Symptom", "id": "s7223"}
{"text": " 3.充血性心力衰竭、不稳定性心绞痛、入组前6个月内有心肌梗塞病史、研究者认为的未被控制的高血压以及高风险、未被控制的心律失常；有其他心脏病史者；LVEF＜55%者；", "label": 5, "label_text": "Multiple", "id": "s7224"}
{"text": "（1）年龄8岁~75岁，男、女不限；", "label": 5, "label_text": "Multiple", "id": "s7225"}
{"text": " 为外来民工子弟学校就读的在校生；", "label": 19, "label_text": "Special Patient Characteristic", "id": "s7226"}
{"text": " 2)在过去的一年中，有酗酒史、嗜烟史、药物滥用史或吸毒史；", "label": 2, "label_text": "Addictive Behavior", "id": "s7227"}
{"text": " 9. 现患有间质性肺病；", "label": 4, "label_text": "Disease", "id": "s7228"}
{"text": " ⑥既往有假体植入史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7229"}
{"text": "①高雄激素血症的其它原因，如产生雄激素的肿瘤", "label": 4, "label_text": "Disease", "id": "s7230"}
{"text": " 贫血: 血红蛋白 &lt;10g/dl；", "label": 5, "label_text": "Multiple", "id": "s7231"}
{"text": " 2.首次脑卒中，病程≤2年；", "label": 4, "label_text": "Disease", "id": "s7232"}
{"text": " （7）近三月内曾采用同类药物治疗，如服用过相关或相拮抗作用的药物，致药物疗效难以判断者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7233"}
{"text": " 3）药物性肝损伤；", "label": 4, "label_text": "Disease", "id": "s7234"}
{"text": " 4)已经妊娠、试验期间准备妊娠，正在授乳的女性；试验期间准备生育的男性。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7235"}
{"text": " (5) WHO化疗毒副作用分级标准等级<ii级； (6)&#32;生存期至少6个月；&nbsp;<=\"\" p=\"\">", "label": 5, "label_text": "Multiple", "id": "s7236"}
{"text": " (5)参与其他影响胚胎移植的干预性研究者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7237"}
{"text": "符合全国第4届脑血管病学术会议通过的《各类脑血管病诊断要点》中关于大脑中动脉主干梗死的诊断标准，并经头颅 CT 和(或) MRI 检查确诊；", "label": 11, "label_text": "Diagnostic", "id": "s7238"}
{"text": " 颅脑开放伤、穿通伤患者；", "label": 4, "label_text": "Disease", "id": "s7239"}
{"text": " 3.妊娠期、哺乳期或意向妊娠的妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7240"}
{"text": " 5）自愿受试并签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7241"}
{"text": " 2.全身情况或治疗", "label": 0, "label_text": "Therapy or Surgery", "id": "s7242"}
{"text": " （4）签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7243"}
{"text": "a.自愿参加并在试验前签署受试者知情同意书，并遵守本研究的要求；", "label": 13, "label_text": "Consent", "id": "s7244"}
{"text": " (5) 术前高血压患者收缩压&gt;180mmHg和（或）舒张压&gt;110mmHg，或低血压患者&lt; 90/60mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7245"}
{"text": "1.年龄：18岁至75岁之间；", "label": 3, "label_text": "Age", "id": "s7246"}
{"text": "（1）年龄18岁以上，性别不限；", "label": 5, "label_text": "Multiple", "id": "s7247"}
{"text": " (6)签署知情同意，依从性好。", "label": 5, "label_text": "Multiple", "id": "s7248"}
{"text": " 2.没有任何辅助设备至少可以步行10米", "label": 17, "label_text": "Capacity", "id": "s7249"}
{"text": " 2）接受伏立康唑（威凡，静脉滴注）预防或治疗侵袭性真菌感染", "label": 5, "label_text": "Multiple", "id": "s7250"}
{"text": " ?随机前7天内有过全身麻醉的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7251"}
{"text": " （4） 育龄期女性受试者需满足下列条件：", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7252"}
{"text": " 4、严重的泌尿系感染伴发热", "label": 4, "label_text": "Disease", "id": "s7253"}
{"text": " 12.研究者认为患者的实际情况不适合参加研究。", "label": 21, "label_text": "Researcher Decision", "id": "s7254"}
{"text": " 10. 已签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7255"}
{"text": " 3. 查阅既往病历资料齐全。", "label": 22, "label_text": "Data Accessible", "id": "s7256"}
{"text": " 4)患者及其家属或监护人对本研究知情同意，并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s7257"}
{"text": " ③ 高尿酸血症的患者未开始进行任何降尿酸治疗。", "label": 5, "label_text": "Multiple", "id": "s7258"}
{"text": " 6）有严重精神和神经性疾病的患者；", "label": 4, "label_text": "Disease", "id": "s7259"}
{"text": " 10、严重钙化的病变。", "label": 4, "label_text": "Disease", "id": "s7260"}
{"text": " 2. 无法合作者，如精神病患者；", "label": 5, "label_text": "Multiple", "id": "s7261"}
{"text": " 8)充血性心力衰竭（NYHAII-IV）；", "label": 4, "label_text": "Disease", "id": "s7262"}
{"text": " 9.筛选时乙肝五项检测HBsAg阳性，或同时满足以下三种情况：抗-HBc阳性、抗-HBs阴性和HBV-DNA超过正常值范围；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7263"}
{"text": "①因各种原因已发生上肢水肿的患者；", "label": 1, "label_text": "Sign", "id": "s7264"}
{"text": " （5）因精神障碍等不能完成问卷填写者；", "label": 5, "label_text": "Multiple", "id": "s7265"}
{"text": " 8、AST、ALT超过正常上限3倍、Ccr≤50ml/min者；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7266"}
{"text": " 3、水疱皮过厚无法挑破的足癣患者", "label": 4, "label_text": "Disease", "id": "s7267"}
{"text": " ⑧对噪音、低温环境反应强烈及空间幽闭恐惧症患者。", "label": 5, "label_text": "Multiple", "id": "s7268"}
{"text": " 5.预期寿命至少6个月。", "label": 23, "label_text": "Life Expectancy", "id": "s7269"}
{"text": " 4.愿意配合本试验治疗方案并签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7270"}
{"text": "① 18-80周岁；", "label": 3, "label_text": "Age", "id": "s7271"}
{"text": " (4)筛选前3个月内献血或失血≥400mL，或接受过输血；或筛选前1个月内献血或失血≥200mL；", "label": 5, "label_text": "Multiple", "id": "s7272"}
{"text": " ④首次脑卒中，病程≤1年；", "label": 4, "label_text": "Disease", "id": "s7273"}
{"text": "1）与乙型肝炎有关", "label": 4, "label_text": "Disease", "id": "s7274"}
{"text": " 4.血流动力学不稳定患者；", "label": 1, "label_text": "Sign", "id": "s7275"}
{"text": " 1.3存在未恢复的 I 度以上以往治疗的不良反应（脱发除外）；", "label": 5, "label_text": "Multiple", "id": "s7276"}
{"text": " ②无严重心脑疾病和肾功能不全；", "label": 5, "label_text": "Multiple", "id": "s7277"}
{"text": " 3、年龄≥18岁且≤60岁；", "label": 3, "label_text": "Age", "id": "s7278"}
{"text": "①美国麻醉医师学会（ASA）分级Ⅰ~Ⅲ级", "label": 9, "label_text": "Risk Assessment", "id": "s7279"}
{"text": " 3.伴严重系统疾病：如重症肝肾功能不全;", "label": 5, "label_text": "Multiple", "id": "s7280"}
{"text": " 7、同意签署知情同意书，愿意参加本研究。", "label": 13, "label_text": "Consent", "id": "s7281"}
{"text": "1、感染、恶性肿瘤、自身免疫疾病；", "label": 4, "label_text": "Disease", "id": "s7282"}
{"text": " (6) 妇女怀孕的；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7283"}
{"text": " (14)有两种及以上恶性肿瘤者（皮肤基底细胞癌或皮肤鳞状细胞癌或宫颈原位癌彻底治愈患者除外）；", "label": 4, "label_text": "Disease", "id": "s7284"}
{"text": " 3 凝血障碍（血小板&lt;50×109/L，凝血酶原活动度&lt;50%）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7285"}
{"text": " c.正在参加其他临床试验者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7286"}
{"text": " 2. 药物性继发性AML", "label": 4, "label_text": "Disease", "id": "s7287"}
{"text": " (2)高血压控制不良者（治疗后收缩压≥160mmHg或舒张压≥100mmHg）；", "label": 5, "label_text": "Multiple", "id": "s7288"}
{"text": "×先天发育异常", "label": 4, "label_text": "Disease", "id": "s7289"}
{"text": " 2. 严格符合《原发性肝癌诊疗规范》（2011年版）临床诊断标准或经病理组织学或者细胞学检查确诊的复发/转移的不可切除的HCC患者，并且无法接受姑息性手术或放射治疗，且至少有一个可测量病灶；", "label": 5, "label_text": "Multiple", "id": "s7290"}
{"text": " 2.拟行腔镜单侧肾部分切除或肾根治术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7291"}
{"text": " 2.对局麻药过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s7292"}
{"text": " 7) 参加本项临床研究的医务工作者。", "label": 26, "label_text": "Encounter", "id": "s7293"}
{"text": " ④伴随重度心肾功能不全等高危，影响试验安全性评价的患者。", "label": 6, "label_text": "Organ or Tissue Status", "id": "s7294"}
{"text": " (5)签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7295"}
{"text": " B.曾患神经系统疾病（包括中风、视神经脊髓炎、帕金森病、癫痫等）；", "label": 4, "label_text": "Disease", "id": "s7296"}
{"text": " (6)拟行择期四肢或者腹腔手术的患者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7297"}
{"text": " ⑧根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，如工作环境经常变动等易造成失访的情况；", "label": 21, "label_text": "Researcher Decision", "id": "s7298"}
{"text": " 4.参加者或监护人充分了解试验内容，愿意参加实验，已签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7299"}
{"text": " （12）各种原因长期卧床者；", "label": 38, "label_text": "Nursing", "id": "s7300"}
{"text": " 2、年龄50-80岁，麻醉分级I-II级", "label": 5, "label_text": "Multiple", "id": "s7301"}
{"text": " 10.在研究期间患者需有能力且自愿进行随访。", "label": 8, "label_text": "Compliance with Protocol", "id": "s7302"}
{"text": " 4)有严重心血管疾病史（如Ⅲ/Ⅳ级的充血性心脏衰竭，增加血栓栓塞事件的发生风险的心律失常或心绞痛，不稳定型心绞痛，进行过冠状动脉支架置入术，血管成形术或冠状动脉旁路移植术）。", "label": 5, "label_text": "Multiple", "id": "s7303"}
{"text": " 3）遗传性：牙龈纤维瘤病", "label": 4, "label_text": "Disease", "id": "s7304"}
{"text": " 5)东部肿瘤协作组体能状态（ECOG P.S)评分为0或者1。", "label": 9, "label_text": "Risk Assessment", "id": "s7305"}
{"text": " （16）既往已入组过本研究。", "label": 19, "label_text": "Special Patient Characteristic", "id": "s7306"}
{"text": " （13）妊娠期以及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7307"}
{"text": " 9.精神病患者，或认知功能障碍；", "label": 4, "label_text": "Disease", "id": "s7308"}
{"text": " （2）分娩前后使用抗生素", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7309"}
{"text": " 2.有严重的基础疾病控制不佳，不适合进行造血干细胞移植；", "label": 5, "label_text": "Multiple", "id": "s7310"}
{"text": " 14.肢体残疾，或其他原因引起的生活不能自理、不能清楚地回忆、回答问题者；", "label": 5, "label_text": "Multiple", "id": "s7311"}
{"text": " [7]电极放置部位皮肤完整性受损。对电极凝胶或粘合剂过敏；", "label": 5, "label_text": "Multiple", "id": "s7312"}
{"text": " 4.经周期规则（3-7天/24-40天）；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7313"}
{"text": " (3)有心脏病病史（如心源性休克、房室传导阻滞等），或呼吸系统疾病病史，或体位性低血压史，或晕针或晕血史者；", "label": 5, "label_text": "Multiple", "id": "s7314"}
{"text": " 16)影像学显示肿瘤侵犯重要血管或经研究者判断在后续研究期间肿瘤极有可能侵袭重要血管而引起致命大出血的患者；", "label": 21, "label_text": "Researcher Decision", "id": "s7315"}
{"text": " 3、筛选前3个月内出现以下2项或2项以上症状并且达到中度或重度水平：上腹部疼痛、上腹部不适、餐后饱胀、上腹部饱胀、早饱、恶心、呕吐或嗳气（其中1项为餐后饱胀或早饱）的受试者；", "label": 5, "label_text": "Multiple", "id": "s7316"}
{"text": " c)一般情况差，心血管、呼吸、肝、肾或其他主要系统功能障碍；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s7317"}
{"text": " 4).预期生存时间&gt;7天", "label": 23, "label_text": "Life Expectancy", "id": "s7318"}
{"text": " ⑦体重指数小于18.5或大于等于24者。", "label": 9, "label_text": "Risk Assessment", "id": "s7319"}
{"text": " 13)患者拒绝参加本研究", "label": 13, "label_text": "Consent", "id": "s7320"}
{"text": " g)没有长期服用可能影响屈光状态的药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7321"}
{"text": " ④物质滥用者。", "label": 2, "label_text": "Addictive Behavior", "id": "s7322"}
{"text": " 2）拟进行二次剖腹探查术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7323"}
{"text": "（1）糖尿病（2014年ADA诊断标准）；", "label": 4, "label_text": "Disease", "id": "s7324"}
{"text": " 5）近三个月内服用治疗不孕症相关中药或中成药的患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7325"}
{"text": " 6、任何病史，据研究者判断可能干扰试验结果或增加患者治疗风险。", "label": 21, "label_text": "Researcher Decision", "id": "s7326"}
{"text": " 7.配戴矫正眼镜后近距外隐斜&gt;10PD", "label": 34, "label_text": "Device", "id": "s7327"}
{"text": " (4)签署患者知情同意书", "label": 13, "label_text": "Consent", "id": "s7328"}
{"text": " 3, 签署知情同意书并能配合随访。", "label": 13, "label_text": "Consent", "id": "s7329"}
{"text": " 3)行动自如、配合检查；", "label": 5, "label_text": "Multiple", "id": "s7330"}
{"text": "（1）合并心、肾功能不全，急性冠脉综合症，脑血管意外，造血系统疾患及精神疾病患者；", "label": 5, "label_text": "Multiple", "id": "s7331"}
{"text": " 5.对本试验的任何药物成分有过敏反应史或使用禁忌症；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7332"}
{"text": " 10.全身状况差，研究者认为无法评价疗效或不大可能完成预期疗程和随访的患者", "label": 21, "label_text": "Researcher Decision", "id": "s7333"}
{"text": " 2、抗核抗体滴度＞1:100或阳性；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7334"}
{"text": " （3）在研究开始2周之前特殊饮食或服用膳食替代品减肥者；", "label": 18, "label_text": "Diet", "id": "s7335"}
{"text": "1）试验前签署知情同意书，并对试验内容、过程及可能出现的不良反应充分了解；", "label": 13, "label_text": "Consent", "id": "s7336"}
{"text": "（1）全身状况良好。", "label": 32, "label_text": "Healthy", "id": "s7337"}
{"text": " (4)无器官疾病史和药物过敏史者。", "label": 5, "label_text": "Multiple", "id": "s7338"}
{"text": " （4）肝组织病理学符合慢性肝炎诊断标准(见附件1); 诊断符合上述标准者(其中具备a、b、c项或a、b、d项，即可诊断为慢性乙型肝炎肝损伤) 。", "label": 11, "label_text": "Diagnostic", "id": "s7339"}
{"text": " 有精神病史者；", "label": 4, "label_text": "Disease", "id": "s7340"}
{"text": " 2.符合复发性口腔溃疡诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7341"}
{"text": " 6. 视力至少能矫正到6/9.5或以上。", "label": 12, "label_text": "Laboratory Examinations", "id": "s7342"}
{"text": " 2)目前患者存在严重的自杀风险，或HAMD17第3条-自杀评分≥3分；", "label": 5, "label_text": "Multiple", "id": "s7343"}
{"text": "1 ASA I ~ III级,出生小于28天的新生儿；", "label": 5, "label_text": "Multiple", "id": "s7344"}
{"text": " 5)18≤BMI≤26kg/㎡", "label": 9, "label_text": "Risk Assessment", "id": "s7345"}
{"text": " 23)精神或躯体上的残疾患者。", "label": 33, "label_text": "Disabilities", "id": "s7346"}
{"text": " 5、签署知情同意书者。", "label": 13, "label_text": "Consent", "id": "s7347"}
{"text": " (5) 病情不稳定的高血压患者；", "label": 4, "label_text": "Disease", "id": "s7348"}
{"text": " 3）先天性眼部疾病患者", "label": 4, "label_text": "Disease", "id": "s7349"}
{"text": " 3、术前超声无淋巴结转移证据。", "label": 11, "label_text": "Diagnostic", "id": "s7350"}
{"text": " （6）血压升高（收缩压&gt;185mmHg，舒张压&gt;110mmHg）", "label": 1, "label_text": "Sign", "id": "s7351"}
{"text": " （4）对青霉素或甲硝唑过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7352"}
{"text": " 2. 糖尿病；", "label": 4, "label_text": "Disease", "id": "s7353"}
{"text": " 4. 骨髓造血功能正常，无出血倾向（INR&lt;1.5），血常规：HGB≥90g/L、WBC&gt;4.0×10^9/L (NEU≥1.5×10^9/L)、 PLT≥80×10^9/L；", "label": 5, "label_text": "Multiple", "id": "s7354"}
{"text": " （3）有活动性的心内膜炎的患者", "label": 4, "label_text": "Disease", "id": "s7355"}
{"text": " 8)合并风湿或结缔组织病", "label": 4, "label_text": "Disease", "id": "s7356"}
{"text": " 7.合并严重的心、肺、肝、肾等疾病;", "label": 4, "label_text": "Disease", "id": "s7357"}
{"text": " 2.新导入维持性腹膜透析治疗（腹膜透析时间≥90天且≤6个月）", "label": 0, "label_text": "Therapy or Surgery", "id": "s7358"}
{"text": " （4）血压在收缩压&lt;180 mmHg；舒张压&lt;100mmHg", "label": 12, "label_text": "Laboratory Examinations", "id": "s7359"}
{"text": " 2.尿液百草枯半定量实验阳性。", "label": 12, "label_text": "Laboratory Examinations", "id": "s7360"}
{"text": " 2.有过胃肠道手术史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7361"}
{"text": " 3)免疫性疾病引起的关节炎", "label": 4, "label_text": "Disease", "id": "s7362"}
{"text": " (3)卡氏评分(Karnofsky,KPS)70分以上；", "label": 9, "label_text": "Risk Assessment", "id": "s7363"}
{"text": " 2、经病理组织学或细胞学检查确诊为SCLC；", "label": 11, "label_text": "Diagnostic", "id": "s7364"}
{"text": "① 男性，包皮过长和包茎者，年龄18岁～60岁；", "label": 5, "label_text": "Multiple", "id": "s7365"}
{"text": " 3.妊娠", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7366"}
{"text": " ③ 皮肤或结缔组织疾病可能影响愈合者。", "label": 4, "label_text": "Disease", "id": "s7367"}
{"text": " ③突发意识障碍后12周以上。", "label": 4, "label_text": "Disease", "id": "s7368"}
{"text": "1. 屈光介质混浊难以进行眼底图像评价者。", "label": 1, "label_text": "Sign", "id": "s7369"}
{"text": " 10.具有明显影响口服药物吸收的因素，如无法吞咽、慢性腹泻和肠梗阻等；", "label": 5, "label_text": "Multiple", "id": "s7370"}
{"text": " 3.进行口服降糖治疗的患者", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7371"}
{"text": " ⑤存在宫腔镜治疗禁忌者。", "label": 4, "label_text": "Disease", "id": "s7372"}
{"text": " （5）KPS评分≥60分；", "label": 9, "label_text": "Risk Assessment", "id": "s7373"}
{"text": " 3.研究前使用第三代AI（阿那曲唑、来曲唑或依西美坦）至少30天；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7374"}
{"text": " 手术中出血≥1500ml；术中需输血等；", "label": 5, "label_text": "Multiple", "id": "s7375"}
{"text": " （2）近期服用促运动药、抗胆碱能药或多巴胺能药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7376"}
{"text": " (4)符合中医证型辨证标准；", "label": 11, "label_text": "Diagnostic", "id": "s7377"}
{"text": " 2.移植后1月处于血液学缓解状态。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7378"}
{"text": " ②术前、术中发现远处脏器转移或腹腔广泛种植转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s7379"}
{"text": " 2）年龄在 18～70岁；", "label": 3, "label_text": "Age", "id": "s7380"}
{"text": " 3.参与本试验时口腔内有1～3个溃疡，而且溃疡直径小于10mm，发生不超过48小时。", "label": 4, "label_text": "Disease", "id": "s7381"}
{"text": " (8)除生殖系统外其他系统严重疾病", "label": 4, "label_text": "Disease", "id": "s7382"}
{"text": " （2）活动性神经精神性狼疮；", "label": 4, "label_text": "Disease", "id": "s7383"}
{"text": " 16. 研究者认为不宜进行此项临床研究者。", "label": 21, "label_text": "Researcher Decision", "id": "s7384"}
{"text": " 2）既往存在神经肌肉病变的患者；", "label": 4, "label_text": "Disease", "id": "s7385"}
{"text": " 4.失眠症状每周至少发生3天或3天以上，持续至少1个月", "label": 42, "label_text": "Bedtime", "id": "s7386"}
{"text": " 4. 预期复发后30天内可能会出现早期死亡的患者", "label": 23, "label_text": "Life Expectancy", "id": "s7387"}
{"text": " ③皮损面积小于30%；", "label": 4, "label_text": "Disease", "id": "s7388"}
{"text": " (16)研究者判定其它原因不适合参加本研究的患者。", "label": 21, "label_text": "Researcher Decision", "id": "s7389"}
{"text": " —姑息放疗结束 ≥ 3个月，且复发转移灶为非放疗病灶者", "label": 5, "label_text": "Multiple", "id": "s7390"}
{"text": " (3)确诊下呼吸道感染（急性支气管炎，肺炎）的住院患儿", "label": 4, "label_text": "Disease", "id": "s7391"}
{"text": " 4，对速尿过敏", "label": 7, "label_text": "Allergy Intolerance", "id": "s7392"}
{"text": " 5)无智力及精神障碍，语言表达能力正常，能合作评价症状及生活质量；", "label": 5, "label_text": "Multiple", "id": "s7393"}
{"text": "(1)近期(3个月内)有疼痛史(包括痛经)，女性受试者月经期、妊娠期、哺乳期；", "label": 5, "label_text": "Multiple", "id": "s7394"}
{"text": " ④精神病患者；", "label": 4, "label_text": "Disease", "id": "s7395"}
{"text": " 2.过去6周内胃肠道或泌尿生殖道出血史。", "label": 4, "label_text": "Disease", "id": "s7396"}
{"text": " 9,不能配合试验者或临床医生认为不适合受试的其他患者", "label": 5, "label_text": "Multiple", "id": "s7397"}
{"text": " 7）入组前3个月参加过其它同类研究者等。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7398"}
{"text": "1、经检查证实为感染性腹泻、炎症性肠病、寄生虫感染、大便潜血阳性者、结直肠肿瘤、吸收不良综合征、乳糖不耐受（结合病史）以及全身性疾病等引起的腹泻；", "label": 11, "label_text": "Diagnostic", "id": "s7399"}
{"text": " ?KPS评分≥70分；", "label": 9, "label_text": "Risk Assessment", "id": "s7400"}
{"text": "①足底疼痛，时间超过3个月；", "label": 1, "label_text": "Sign", "id": "s7401"}
{"text": "（1) 患者年龄18～70周岁，男女不限，签署知情同意书；", "label": 5, "label_text": "Multiple", "id": "s7402"}
{"text": "（1）年龄大于18岁；", "label": 3, "label_text": "Age", "id": "s7403"}
{"text": " (4) 基本生活功能正常；", "label": 1, "label_text": "Sign", "id": "s7404"}
{"text": " （2）前庭功能受损；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s7405"}
{"text": " 2.合并下肢水肿、右心衰竭和血流动力学不稳定等征象", "label": 1, "label_text": "Sign", "id": "s7406"}
{"text": " 7. 入选前3月内有心肌梗死或脑血管事件;", "label": 4, "label_text": "Disease", "id": "s7407"}
{"text": " -造血功能低下", "label": 6, "label_text": "Organ or Tissue Status", "id": "s7408"}
{"text": " 6)中风次数≥3次者。", "label": 4, "label_text": "Disease", "id": "s7409"}
{"text": " 4)血肌酐&lt;1.5mg/dl，胆红素&lt;1.5mg/dl，转氨酶小于正常高值3倍以下，或白血病合并肝脏累及转氨酶可小于正常高值5倍以下；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7410"}
{"text": " （5）适合单独或合并弹簧圈使用Tubridge血管重建装置，或Enterprise支架合并弹簧圈治疗的患者；", "label": 34, "label_text": "Device", "id": "s7411"}
{"text": " (6). 不能按要求服药者。", "label": 17, "label_text": "Capacity", "id": "s7412"}
{"text": " 2. 入住ICU前被诊断为BSI；", "label": 4, "label_text": "Disease", "id": "s7413"}
{"text": " ?(4)女性生殖系统无先天发育畸形及器质性病变;", "label": 4, "label_text": "Disease", "id": "s7414"}
{"text": "        8.预期生存超过12周；", "label": 23, "label_text": "Life Expectancy", "id": "s7415"}
{"text": " 2)合并有心、脑、肝、肾和造血系统等严重疾病、恶性肿瘤，其中ALT、AST＞正常值范围上限的1.2倍，Cr＞正常值上限者；", "label": 5, "label_text": "Multiple", "id": "s7416"}
{"text": " 3）罹患其他严重疾病而无法完成筛查程序者；", "label": 4, "label_text": "Disease", "id": "s7417"}
{"text": " 2. 血肌酐及转氨酶水平正常；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7418"}
{"text": " 7)严重左心衰（心功能III级以上）；", "label": 4, "label_text": "Disease", "id": "s7419"}
{"text": " 6.并发恶性肿瘤或正在进行抗治疗", "label": 5, "label_text": "Multiple", "id": "s7420"}
{"text": " （3）有腰椎手术史者；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7421"}
{"text": " 7）本科题组认为不适合纳入研究的患者", "label": 21, "label_text": "Researcher Decision", "id": "s7422"}
{"text": " 3.不能阅读或不能独立完成问卷调查的患者", "label": 17, "label_text": "Capacity", "id": "s7423"}
{"text": " 10.在随机分组前7天内，有足够的肝肾功能，合适的实验室指标（未经处理）：HGB≧9.0g/dl，中性粒细胞≧1,500/mm3，PLT≧50x109/L，血清ALB≧28g/L，TBIL&lt;2 mg/dL，ALT、AST&lt; 5倍正常值上限值，Bun、Cr&lt;1.5倍的正常上限值，INR&lt;1.7或PT延长&lt;4s", "label": 5, "label_text": "Multiple", "id": "s7424"}
{"text": " （6）糖尿病患者", "label": 4, "label_text": "Disease", "id": "s7425"}
{"text": " 注：1)疼痛NRS评分即疼痛数字评分法（Numerical Rating Scal,NRS）,是指11等级（0－10）的数字等级量表评分。2)Bristol粪便性状量表见附件2。", "label": 9, "label_text": "Risk Assessment", "id": "s7426"}
{"text": " 3、可能患有其它疾病不宜参加本次试验的受试者；", "label": 5, "label_text": "Multiple", "id": "s7427"}
{"text": " （3）有明显严重全身器质性疾病者；", "label": 4, "label_text": "Disease", "id": "s7428"}
{"text": " C、孕妇哺乳期女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7429"}
{"text": " 10 实验室检查：总胆红素＞1.5倍正常值上限（ULN）；AST和/或ALT＞2.5倍正常值上限（ULN）且伴有碱性磷酸酶＞2.5倍正常值上限（ULN）；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7430"}
{"text": " （5）肝纤维硬度扫描：大于12.4分", "label": 9, "label_text": "Risk Assessment", "id": "s7431"}
{"text": " ③合并心、肝、肾和造血系统等严重原发病的患者。", "label": 4, "label_text": "Disease", "id": "s7432"}
{"text": " 3.重度钙化需要旋磨处理的。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7433"}
{"text": " ②伴有其他严重糖尿病心、脑、肾、眼等并发症者；", "label": 4, "label_text": "Disease", "id": "s7434"}
{"text": "1.不愿意参加的患者；", "label": 13, "label_text": "Consent", "id": "s7435"}
{"text": " 6.在参加其他临床试验可能影响最终评定结果的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7436"}
{"text": " c. 应用大量抗生素眼液引起的干眼病患者;", "label": 5, "label_text": "Multiple", "id": "s7437"}
{"text": "    ⑤预计生存期＞3个月；", "label": 23, "label_text": "Life Expectancy", "id": "s7438"}
{"text": "男性健康志愿者，18～40岁；", "label": 5, "label_text": "Multiple", "id": "s7439"}
{"text": " E.存在不可纠正的视、听障碍不能完成神经心理测验和量表评定；", "label": 9, "label_text": "Risk Assessment", "id": "s7440"}
{"text": " 2)既往有精神病史、有躯体疾病存在者；", "label": 4, "label_text": "Disease", "id": "s7441"}
{"text": " 9. 任何影响正常眼镜配戴的解剖结构异常、皮肤过敏或其它方面的情况。", "label": 7, "label_text": "Allergy Intolerance", "id": "s7442"}
{"text": " 2.在心脏移植名单中；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7443"}
{"text": "1）疾病相关：", "label": 4, "label_text": "Disease", "id": "s7444"}
{"text": "① 符合原发性高血压病诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7445"}
{"text": " 7）脑血管疾病患者", "label": 4, "label_text": "Disease", "id": "s7446"}
{"text": " 2. 300mg/g(&gt; 30mg/mmol) &gt;ACR≥30mg/g(3mg/mmol)。", "label": 12, "label_text": "Laboratory Examinations", "id": "s7447"}
{"text": "1）年龄&gt;18周岁，且&lt;80岁，性别男女均可；", "label": 5, "label_text": "Multiple", "id": "s7448"}
{"text": " 4.符合脾肾气虚型中医辩证分型标准；", "label": 11, "label_text": "Diagnostic", "id": "s7449"}
{"text": " 3. 血肌酐&gt;265μmol/L;", "label": 12, "label_text": "Laboratory Examinations", "id": "s7450"}
{"text": " ④对试验药物可疑或明确过敏；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7451"}
{"text": " j)同时参与另一项临床研究的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s7452"}
{"text": " ②年龄20~75yr；", "label": 3, "label_text": "Age", "id": "s7453"}
{"text": " 6.   预计生存期≥3个月", "label": 23, "label_text": "Life Expectancy", "id": "s7454"}
{"text": " 11．严重肝肾功能不全者（丙氨酸氨基转移酶或胆红素大于 3 倍上限，肌酐清除率小于 30ml/min）；", "label": 5, "label_text": "Multiple", "id": "s7455"}
{"text": " 5.既往有明确的神经或精神障碍史，包括癫痫或痴呆；", "label": 4, "label_text": "Disease", "id": "s7456"}
{"text": " 4.既往有神经、精神疾病史，癫痫病史；", "label": 4, "label_text": "Disease", "id": "s7457"}
{"text": " ⑷ NIHSS积分≥5分者；", "label": 9, "label_text": "Risk Assessment", "id": "s7458"}
{"text": " 4、CKD 3b~4期：eGFR 15~45 mL/min/1.73m2；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7459"}
{"text": " ②年龄≥65岁，男性，ASA分级Ⅰ或Ⅱ级，体重指数(BMI) 18-24kg/m2", "label": 5, "label_text": "Multiple", "id": "s7460"}
{"text": "（1）根据ROP国际诊断标准，经我院眼科医师确诊为早产儿视网膜病变患儿，并在我院进行该病的诊治及随访;", "label": 11, "label_text": "Diagnostic", "id": "s7461"}
{"text": "1.患者经妇科及B超检查由器质性病变导致的继发性痛经者", "label": 5, "label_text": "Multiple", "id": "s7462"}
{"text": " d.患有其他慢性疾病如肺结核、哮喘、免疫风湿病等；", "label": 4, "label_text": "Disease", "id": "s7463"}
{"text": " Ⅱ.耶鲁-布郎强迫量表（Y-BOCS）总分&gt;11分，汉密尔顿抑郁量表（HAMD-17）评分&lt;18分；", "label": 9, "label_text": "Risk Assessment", "id": "s7464"}
{"text": " 手术时间≥4h。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7465"}
{"text": " ②2型糖尿病患者，", "label": 4, "label_text": "Disease", "id": "s7466"}
{"text": " 3．签署知情同意书。", "label": 13, "label_text": "Consent", "id": "s7467"}
{"text": " ③双相障碍；", "label": 4, "label_text": "Disease", "id": "s7468"}
{"text": "（1）符合胸腔镜肺叶切除手术适应征，", "label": 5, "label_text": "Multiple", "id": "s7469"}
{"text": " 2、拒绝加入本研究", "label": 13, "label_text": "Consent", "id": "s7470"}
{"text": " 2.嵌合抗原受体治疗或其他转基因T细胞治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7471"}
{"text": " 3. 结肠癌、慢性肠道疾病（IBD、IBS等）患者。", "label": 4, "label_text": "Disease", "id": "s7472"}
{"text": " 2、肛门镜下无明显肿物及隆起", "label": 4, "label_text": "Disease", "id": "s7473"}
{"text": " 7. 肾功能衰竭需立即进行透析者。", "label": 5, "label_text": "Multiple", "id": "s7474"}
{"text": " （5）1个月内使用PPI", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7475"}
{"text": " 4)明确诊断为单眼或双眼弱视患儿。", "label": 4, "label_text": "Disease", "id": "s7476"}
{"text": " 5. 无法吞咽、慢性腹泻和肠梗阻，明显影响药物服用和吸收；", "label": 5, "label_text": "Multiple", "id": "s7477"}
{"text": " 3、最近发生的心肌梗塞、不稳定心绞痛者；", "label": 4, "label_text": "Disease", "id": "s7478"}
{"text": " （7）受试者可以按期复诊；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7479"}
{"text": " 13)心电图异常有临床意义；", "label": 34, "label_text": "Device", "id": "s7480"}
{"text": " ②有确切的证据诊断为继发性高血压患者；", "label": 11, "label_text": "Diagnostic", "id": "s7481"}
{"text": "1. 年龄3月～3岁；", "label": 3, "label_text": "Age", "id": "s7482"}
{"text": " 8)（问诊）试验前14天内服用过任何药物者（包括中草药）；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7483"}
{"text": " 2.合并有急性或者慢性咽喉及气管疾病；", "label": 4, "label_text": "Disease", "id": "s7484"}
{"text": "年龄：45-80岁;", "label": 3, "label_text": "Age", "id": "s7485"}
{"text": " 2.完全符合美国精神病学会编制的精神障碍《诊断和统计手册》第四版(DSM-IV)中关于自闭症儿童自闭症的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7486"}
{"text": " 6. 低蛋白血症在使用替考拉宁前被纠正的患者。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7487"}
{"text": " 3.同时进行抗凝治疗或有凝血功能障碍；", "label": 5, "label_text": "Multiple", "id": "s7488"}
{"text": " 7．在连续3天排尿日志卡的填写中，日平均排尿次数（以24小时计）≥8次", "label": 19, "label_text": "Special Patient Characteristic", "id": "s7489"}
{"text": " 9. 处于孕期或哺乳期。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7490"}
{"text": " (8)阿片类药物滥用；", "label": 2, "label_text": "Addictive Behavior", "id": "s7491"}
{"text": " （4）&lt;3个月眼内手术或出血性视网膜病变；&lt;10天内大手术、白内障手术、创伤、心肺复苏、分娩及其他侵入性操作史；", "label": 5, "label_text": "Multiple", "id": "s7492"}
{"text": " 年龄18-65岁；", "label": 3, "label_text": "Age", "id": "s7493"}
{"text": " ⑸NYHA心功能分级Ⅳ级，血流动力学不稳定，不能平卧24h以上；", "label": 5, "label_text": "Multiple", "id": "s7494"}
{"text": " 7.伴有严重的冠心病、心肌梗塞或脑卒中，癌症；", "label": 4, "label_text": "Disease", "id": "s7495"}
{"text": " ③服用免疫抑制药物患者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7496"}
{"text": " 2、高血压控制不良（收缩压≥160mmHg或舒张压≥100mmHg）、重度心肺功能不全（EF＜35%）、重度心律失常（快速房颤、房扑、阵发性室速、II0 II型以上房室传导阻滞，完全性束支传导阻滞）者；", "label": 5, "label_text": "Multiple", "id": "s7497"}
{"text": " 4 研究者认为不适合入组者。", "label": 21, "label_text": "Researcher Decision", "id": "s7498"}
{"text": "1.经影像学、病理组织学和/或细胞学确诊的胶质母细胞瘤、间变性星形细胞瘤受试者及其他可接受含替莫唑胺方案治疗的肿瘤受试者；", "label": 5, "label_text": "Multiple", "id": "s7499"}
{"text": " 3.经询问，有吸毒史或药物滥用史者。", "label": 2, "label_text": "Addictive Behavior", "id": "s7500"}
{"text": " ⑥ 妊娠和哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7501"}
{"text": " ⑦近3个月内参加其他临床试验的患者。", "label": 15, "label_text": "Enrollment in other studies", "id": "s7502"}
{"text": " 4.哺乳期或妊娠期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7503"}
{"text": " 2.CT及MRI评估侵犯血管，为交界可切除胰腺癌；", "label": 5, "label_text": "Multiple", "id": "s7504"}
{"text": "①年龄18～70岁；", "label": 3, "label_text": "Age", "id": "s7505"}
{"text": " 6. 胃切除手术的患者或胃粘膜高级别上皮内瘤变者", "label": 5, "label_text": "Multiple", "id": "s7506"}
{"text": " （6）现患有较严重慢性病、代谢性疾病（如糖尿病）、神经及精神疾病。", "label": 4, "label_text": "Disease", "id": "s7507"}
{"text": " 2)术前病理学证据支持直肠癌诊断；", "label": 11, "label_text": "Diagnostic", "id": "s7508"}
{"text": " 7．使用附录1 A列举的禁用药物", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7509"}
{"text": " ③合并肝、肾及心脑血管疾病、传染性疾病、肿瘤及精神类疾病患者；", "label": 4, "label_text": "Disease", "id": "s7510"}
{"text": " 1.3年龄18－80岁，男女不限。", "label": 5, "label_text": "Multiple", "id": "s7511"}
{"text": " (二)继发性高血压的病史或证据", "label": 4, "label_text": "Disease", "id": "s7512"}
{"text": " （8）肝功能ALT、AST超过参考值上限1.5倍，或肾功能Scr超过参考值上限者；", "label": 5, "label_text": "Multiple", "id": "s7513"}
{"text": " 7. 有严重心血管、呼吸系统、肝肾或肌肉疾病病史；", "label": 4, "label_text": "Disease", "id": "s7514"}
{"text": "（1）自愿加入本试验并签署知情同意书；", "label": 13, "label_text": "Consent", "id": "s7515"}
{"text": "（1）脱发面积≥50%；", "label": 1, "label_text": "Sign", "id": "s7516"}
{"text": " 11) ALT、AST或总胆红素超过正常上限1.5倍以上；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7517"}
{"text": " 8.合并肾功能衰竭的患者；", "label": 6, "label_text": "Organ or Tissue Status", "id": "s7518"}
{"text": " 2）根据严重少弱精子诊断标准：密度&lt;6*10 E6/mL", "label": 11, "label_text": "Diagnostic", "id": "s7519"}
{"text": " 术前检查酸碱平衡紊乱；", "label": 1, "label_text": "Sign", "id": "s7520"}
{"text": "1）年龄为18-65岁", "label": 3, "label_text": "Age", "id": "s7521"}
{"text": " 8.在试验开始前30天内有参加过其他临床试验的患者", "label": 15, "label_text": "Enrollment in other studies", "id": "s7522"}
{"text": " 患者对接受的治疗和随访有良好的依从性。", "label": 8, "label_text": "Compliance with Protocol", "id": "s7523"}
{"text": " 4.支架位于股浅动脉或腘动脉P1段，计算机断层血管造影（CTA）证实原有支架内或支架近端及远端10mm内管腔最小直径小于支架原直径的50%；", "label": 5, "label_text": "Multiple", "id": "s7524"}
{"text": " (2)高度过敏体质或对试验药物过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7525"}
{"text": " 5.非急诊手术或开腹手术", "label": 0, "label_text": "Therapy or Surgery", "id": "s7526"}
{"text": " 5、允许颈部及锁骨上区淋巴结转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s7527"}
{"text": " 3. 无明显支架内（参照血管直径大于等于2.5mm）再狭窄大于等于50%或原位血管狭窄。", "label": 5, "label_text": "Multiple", "id": "s7528"}
{"text": " 2）年龄大于等于18 岁，小于等于80岁，不分男女，垂体瘤患者；", "label": 5, "label_text": "Multiple", "id": "s7529"}
{"text": " 6 .继发性白血病", "label": 4, "label_text": "Disease", "id": "s7530"}
{"text": "1. 孕期及哺乳期的女性；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7531"}
{"text": " 3.符合真菌感染的诊断标准。", "label": 11, "label_text": "Diagnostic", "id": "s7532"}
{"text": " （5）肝功能Child-Pugh A级或B级。", "label": 9, "label_text": "Risk Assessment", "id": "s7533"}
{"text": " 4）给药前2周内使用过或正在使用任何药物者，包括维生素及中草药；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7534"}
{"text": " 3.没有活动性GVHD、活动性感染、器官衰竭、严重的骨髓抑制等干扰素α使用禁忌的患者", "label": 4, "label_text": "Disease", "id": "s7535"}
{"text": " (7)根据研究者的判断、具有降低入组可能性或使入组复杂化的其他病变，如工作环境经常变动等易造成失访的情况。", "label": 21, "label_text": "Researcher Decision", "id": "s7536"}
{"text": " ④ 存有平衡功能障碍，患侧下肢肌张力根据改良Ashworth痉挛评定<ii级，患侧下肢肌力(髂腰肌、股四头肌、腘绳肌、小腿三头肌及胫骨前肌等)>3+级，Brunnstrom分期≥4期，下肢髋、膝、踝关节活动范围正常，Fugl-Meyer平衡评分≥8分；", "label": 5, "label_text": "Multiple", "id": "s7537"}
{"text": "1.符合PNH诊断标准", "label": 11, "label_text": "Diagnostic", "id": "s7538"}
{"text": "  3.近3个月使用过或近期打算使用任何一种生物制剂或糖皮质激素或柳氮磺吡啶，", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7539"}
{"text": " （2）影像学证实阳性结石，结石位置在肾内，结石数量≥1个，最大径大小在2-3cm，或最大径大小在1-2cm，经体外冲击波碎石无效或不愿接受体外冲击波碎石术者；", "label": 5, "label_text": "Multiple", "id": "s7540"}
{"text": " 5.醛固酮症患者；", "label": 4, "label_text": "Disease", "id": "s7541"}
{"text": "1、有系统性疾病，如白塞氏病，风湿性关节炎，红斑狼疮，AIDS等；", "label": 4, "label_text": "Disease", "id": "s7542"}
{"text": " ② 符合DSM-IV 精神分裂症诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7543"}
{"text": " 5）对药物过敏者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s7544"}
{"text": " ⑹ 有妊娠计划者或妊娠、哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7545"}
{"text": " 8.研究者认为不适合参加该试验的任何其他情况等", "label": 21, "label_text": "Researcher Decision", "id": "s7546"}
{"text": " 急性咽炎首发症状(例如,咽喉疼痛)已超过3天。", "label": 5, "label_text": "Multiple", "id": "s7547"}
{"text": " 无影响眼底检查的屈光介质混浊及瞳孔缩小", "label": 1, "label_text": "Sign", "id": "s7548"}
{"text": " 15)研究者认为依从性差，或具有任何不宜参加此试验因素的受试者。", "label": 21, "label_text": "Researcher Decision", "id": "s7549"}
{"text": " 3.术后有急性重度疼痛患者（术后24h内VAS评分大于6分）；", "label": 5, "label_text": "Multiple", "id": "s7550"}
{"text": "1)有严重的系统疾病史，特别是高血压病史、血栓病史、长期吸烟史、高脂血症病史或其他可能导致血栓的相关病史。", "label": 4, "label_text": "Disease", "id": "s7551"}
{"text": " f)筛选期或试验第1天用药前心电图检查结果出现以下任一异常情况：男性QTc&gt;450 ms，女性QTc&gt;470 ms；IIo房室或IIIo 房室传导阻滞；心率&lt;45次/min或&gt;100次/min；PR间期&gt;200 ms 或 &lt;110 ms；QRS波群&gt;120 ms；病理性的Q波（按照Q波&gt;40 ms界定）；室性预激综合征。", "label": 5, "label_text": "Multiple", "id": "s7552"}
{"text": " (2)不能配合完成肺功能检查、痰诱导试验、6min步行距离等检查；", "label": 5, "label_text": "Multiple", "id": "s7553"}
{"text": " （3）新生血管性青光眼；", "label": 4, "label_text": "Disease", "id": "s7554"}
{"text": " （2）血压&gt;180/110mmHg；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7555"}
{"text": " 10.既往无药物及食物过敏史；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7556"}
{"text": "1）同时使用两种或两种以上抗真菌药物；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7557"}
{"text": " 4.育龄期女性患者同意在试验期间采用避孕措施。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7558"}
{"text": " d. 体内有金属植入物", "label": 34, "label_text": "Device", "id": "s7559"}
{"text": " 存在严重基础疾病，包括未控制的高血压、糖尿病、心脏病及脑血管疾病的患者", "label": 4, "label_text": "Disease", "id": "s7560"}
{"text": " 3. 志愿者能遵守临床试验方案的要求，完成所有随访研究；", "label": 8, "label_text": "Compliance with Protocol", "id": "s7561"}
{"text": " 11)存在人类免疫缺陷病毒（HIV）感染或梅毒感染。", "label": 4, "label_text": "Disease", "id": "s7562"}
{"text": " 2,肺癌侵犯第1,2级支气管，可通过实施传统支气管成型或袖型切除实现肺癌根治，并保留肺叶，避免全肺切除的患者。", "label": 5, "label_text": "Multiple", "id": "s7563"}
{"text": " 4）咳嗽能力较差：咳嗽分级0-1级13；", "label": 1, "label_text": "Sign", "id": "s7564"}
{"text": " 7．在参加研究计划前1个月内使用过非甾体类消炎药、对乙酰胺氨基酚或抗组胺药。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7565"}
{"text": " 3)与其他抗肿瘤治疗或药物同步应用；", "label": 5, "label_text": "Multiple", "id": "s7566"}
{"text": " 6). A型及B型血友病患者。", "label": 4, "label_text": "Disease", "id": "s7567"}
{"text": " 4、心律失常需要接受抗心律失常治疗（?受体-阻滞剂、钙离子拮抗剂或地高辛除外）；", "label": 5, "label_text": "Multiple", "id": "s7568"}
{"text": " 2. 盆腔、腹部放疗史", "label": 0, "label_text": "Therapy or Surgery", "id": "s7569"}
{"text": " （2）自愿参与本研究并同意治疗者；", "label": 13, "label_text": "Consent", "id": "s7570"}
{"text": "1.静脉畸形的部位是四肢软组织；", "label": 4, "label_text": "Disease", "id": "s7571"}
{"text": " （8）白细胞计数≥3.0×109/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7572"}
{"text": " 对穴位贴敷贴片过敏者；", "label": 7, "label_text": "Allergy Intolerance", "id": "s7573"}
{"text": " 5)拟行经皮椎体成形术的靶椎体≤3个；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7574"}
{"text": " 4.近期手术史", "label": 0, "label_text": "Therapy or Surgery", "id": "s7575"}
{"text": " 4. 可测量病灶(必须具有至少一个根据 RECIST 1.1 版标准判断的可评价病灶，即最长径至少 10mm)；", "label": 11, "label_text": "Diagnostic", "id": "s7576"}
{"text": " *用药前B超、 CT、核磁共振断层扫描（MR）、肺通气灌注扫描确诊存在栓塞的患者，或不明原因D-二聚体升高1倍，是参考值高限的2倍的患者;", "label": 5, "label_text": "Multiple", "id": "s7577"}
{"text": "（1）疑有肝癌（AFP升高且B超或CT提示肝癌）；", "label": 4, "label_text": "Disease", "id": "s7578"}
{"text": " ②年龄在65至85岁", "label": 3, "label_text": "Age", "id": "s7579"}
{"text": " 4)病人已签署知情同意书（见附件2）。", "label": 13, "label_text": "Consent", "id": "s7580"}
{"text": " 4）同时参与其他临床试验的患者；", "label": 15, "label_text": "Enrollment in other studies", "id": "s7581"}
{"text": " 已诊断为1型、2型糖尿病者；", "label": 11, "label_text": "Diagnostic", "id": "s7582"}
{"text": " （5）胃切除手术的患者", "label": 0, "label_text": "Therapy or Surgery", "id": "s7583"}
{"text": "①年龄18-65周岁。", "label": 3, "label_text": "Age", "id": "s7584"}
{"text": " 2)符合中医肝郁脾虚证诊断标准者；", "label": 11, "label_text": "Diagnostic", "id": "s7585"}
{"text": " ④愿意在本院门诊接受治疗3月以上并完成随访半年者；", "label": 5, "label_text": "Multiple", "id": "s7586"}
{"text": " 2. 年龄18至70岁", "label": 3, "label_text": "Age", "id": "s7587"}
{"text": " ? 患者在移植手术后12月内失随访", "label": 5, "label_text": "Multiple", "id": "s7588"}
{"text": " （2）3个月脑卒中病史，心肌病、瓣膜病及先天性心脏病患者，新发完全性左束支传导阻滞或严重恶性心律失常患者；", "label": 4, "label_text": "Disease", "id": "s7589"}
{"text": " (5) 严重骨质疏松及合并心脑血管、消化、泌尿、血液、内分泌系统等严重疾病或临床控制不达标；", "label": 4, "label_text": "Disease", "id": "s7590"}
{"text": " （3）有药物过敏史或属于过敏体质者。", "label": 7, "label_text": "Allergy Intolerance", "id": "s7591"}
{"text": "①空腹血浆葡萄糖≥6.1mmol/L或餐后2小时血浆葡萄糖或随机血浆葡萄糖≥7.8mmol/L或有T2DM 病史；", "label": 5, "label_text": "Multiple", "id": "s7592"}
{"text": " （4） 临床严重程度(Truelove分度)：重度：腹泻每日6次以上，伴明显粘液血便，体温&gt;37.5度，脉搏&gt;90次/分，血红蛋白&lt;100g/L，红细胞沉降率&gt;30mm/1h。", "label": 5, "label_text": "Multiple", "id": "s7593"}
{"text": " 3)肿瘤的位置未累及黄斑部及视盘，无眼外蔓延及全身转移；", "label": 24, "label_text": "Neoplasm Status", "id": "s7594"}
{"text": " c)建立外周静脉通路2次已经失败，或会延误病人的治疗。", "label": 0, "label_text": "Therapy or Surgery", "id": "s7595"}
{"text": " 6)参加研究前30天内曾经接受过左卡尼汀治疗；对左卡尼汀及其衍生物过敏", "label": 5, "label_text": "Multiple", "id": "s7596"}
{"text": "1．胸段食管鳞癌患者；", "label": 4, "label_text": "Disease", "id": "s7597"}
{"text": " (5) 患有血液系统疾病、有吸烟饮酒习惯；", "label": 5, "label_text": "Multiple", "id": "s7598"}
{"text": " 5、签署知情同意书", "label": 13, "label_text": "Consent", "id": "s7599"}
{"text": " 4. CHA2DS2-VASc评分男性≥1分或女性≥2分；", "label": 9, "label_text": "Risk Assessment", "id": "s7600"}
{"text": " 2)年龄18-70岁男性全麻择期手术患者", "label": 5, "label_text": "Multiple", "id": "s7601"}
{"text": " 5)复发/难治B细胞白血病/淋巴瘤患者；", "label": 4, "label_text": "Disease", "id": "s7602"}
{"text": " 2）影像学检测确认复发；", "label": 11, "label_text": "Diagnostic", "id": "s7603"}
{"text": " 9）根据研究者判断，存在任何情况会导致受试者参与本研究不符合其最佳利益（如有损受试者的健康）或可能会妨碍、限制或干扰研究方案规定的评价", "label": 21, "label_text": "Researcher Decision", "id": "s7604"}
{"text": " (4) 症状发生后48小时入院者；", "label": 26, "label_text": "Encounter", "id": "s7605"}
{"text": " (3)能按计划坚持治疗者。", "label": 8, "label_text": "Compliance with Protocol", "id": "s7606"}
{"text": " 7.受试者能够理解、遵守试验方案，并且签署知情同意书", "label": 5, "label_text": "Multiple", "id": "s7607"}
{"text": " 2）同时合并左髂静脉受压综合征（IVCS），经动静脉双增强CT检查确认髂静脉狭窄度＞50%；", "label": 4, "label_text": "Disease", "id": "s7608"}
{"text": "受试者选择基于美国风湿病协会对膝骨关炎患者的分级标准：", "label": 11, "label_text": "Diagnostic", "id": "s7609"}
{"text": " 4.患者服用相关药物，其副作用影响骨折愈合或伤口愈合。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7610"}
{"text": " （4）介入术前、后心功能为Ⅳ级(NYHA分级或Killip分级)；", "label": 9, "label_text": "Risk Assessment", "id": "s7611"}
{"text": " ?血红蛋白 ≥ 90 g/L；", "label": 12, "label_text": "Laboratory Examinations", "id": "s7612"}
{"text": " 2、脑卒中发病后发生过明显误吸", "label": 4, "label_text": "Disease", "id": "s7613"}
{"text": " 7. 无脑部器质性病变。", "label": 4, "label_text": "Disease", "id": "s7614"}
{"text": " 6.患者拒绝", "label": 13, "label_text": "Consent", "id": "s7615"}
{"text": " 年龄：18岁以上", "label": 3, "label_text": "Age", "id": "s7616"}
{"text": " 5）妊娠或哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7617"}
{"text": " (6)接受随机分组，并日常服用研究药物长达数月。", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7618"}
{"text": " ?无静脉吸毒史", "label": 2, "label_text": "Addictive Behavior", "id": "s7619"}
{"text": " 妊娠、哺乳和计划妊娠的患者；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7620"}
{"text": " 4. 心肺功能之不穩定狀況，例如心肺衰竭、心律不整(使用心律調節器)等", "label": 5, "label_text": "Multiple", "id": "s7621"}
{"text": " 3.受者因终末期肾病即将接受初次同种异体DCD供肾移植手术；", "label": 5, "label_text": "Multiple", "id": "s7622"}
{"text": " 3.目前处于躁狂状态、有精神症状，有自杀倾向的患者", "label": 28, "label_text": "Symptom", "id": "s7623"}
{"text": " 2.符合美国国立卫生院的国家老年研究所和阿尔茨海默病协会(NIA-AA)的“阿尔茨海默病所致轻度认知障碍”的诊断标准（2011）；", "label": 11, "label_text": "Diagnostic", "id": "s7624"}
{"text": " 5.对糖皮质激素治疗效果不佳者；", "label": 16, "label_text": "Pharmaceutical Substance or Drug", "id": "s7625"}
{"text": " 4、急性心肌梗死、充血性心衰，其他急性期心脏病患者；", "label": 4, "label_text": "Disease", "id": "s7626"}
{"text": " 2.严重的视觉或听觉障碍者", "label": 4, "label_text": "Disease", "id": "s7627"}
{"text": " (2)有深静脉血栓或栓塞史者；", "label": 4, "label_text": "Disease", "id": "s7628"}
{"text": " 4. 肌酐&lt;3mg/dl(265μmol/L), eGFR≥30ml/min", "label": 12, "label_text": "Laboratory Examinations", "id": "s7629"}
{"text": " 5)至少经历过一个以上完整的联合化疗/靶向治疗；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7630"}
{"text": " 2) 术前影像学诊断二级支气管以下的右侧支气管肺癌，需行单一肺叶切除手术患者；", "label": 4, "label_text": "Disease", "id": "s7631"}
{"text": "1. 妊娠或哺乳期妇女。", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7632"}
{"text": "1). 经病理学或细胞学确诊为非小细胞肺癌（腺癌）、结直肠癌、胰腺癌III-IV期不能进行手术、介入治疗、放射治疗的患者；", "label": 5, "label_text": "Multiple", "id": "s7633"}
{"text": " （5）提供参加本研究的知情同意书，由受试者本人或法定监护人签署。", "label": 13, "label_text": "Consent", "id": "s7634"}
{"text": " (5) 有外科性前列腺根除术病史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7635"}
{"text": " 5. HbA1C≤9.5%者。", "label": 12, "label_text": "Laboratory Examinations", "id": "s7636"}
{"text": " （4）前3个月无针灸治疗便秘；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7637"}
{"text": " 3、一个或以上肺叶切除病史；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7638"}
{"text": " 2.与实验组平行随访3年，未发现相关神经损伤症状。", "label": 8, "label_text": "Compliance with Protocol", "id": "s7639"}
{"text": " 5)肝、肾功能：血胆红素≤2mg/dL(35 μmol/L)，AST/ALT在正常值上限2倍以下， 血肌苷≤177μmol/L", "label": 5, "label_text": "Multiple", "id": "s7640"}
{"text": " (12) 长期酗酒、吸毒或滥用药物以致影响试验结果评价的患者；", "label": 2, "label_text": "Addictive Behavior", "id": "s7641"}
{"text": " (3)孕妇及哺乳期妇女；", "label": 10, "label_text": "Pregnancy-related Activity", "id": "s7642"}
{"text": " 6、严重糖尿病（采取血糖控制措施后，空腹血糖仍大于8mmol/L）；", "label": 4, "label_text": "Disease", "id": "s7643"}
{"text": "（1）伴有肝癌；", "label": 4, "label_text": "Disease", "id": "s7644"}
{"text": "1.术后发生非计划再次手术；", "label": 0, "label_text": "Therapy or Surgery", "id": "s7645"}
{"text": " 13)不能或不愿提供知情同意或不能遵守试验要求者；", "label": 5, "label_text": "Multiple", "id": "s7646"}
{"text": " （6）恶性肿瘤、心脑血管疾病等重大系统性疾病患者；妊娠及一年内意向妊娠的育龄期妇女及哺乳期妇女；精神疾病患者；", "label": 5, "label_text": "Multiple", "id": "s7647"}
{"text": "1.符合西医慢性肾病 CKD3-5 期的诊断标准；", "label": 11, "label_text": "Diagnostic", "id": "s7648"}
{"text": "1.男性及女性健康中国受试者，年龄18-45岁；", "label": 5, "label_text": "Multiple", "id": "s7649"}
{"text": "⑴年龄≥18岁，经病理确诊的恶性肿瘤拟接受包含顺铂方案25mg/m2/d三日化疗；", "label": 5, "label_text": "Multiple", "id": "s7650"}
{"text": " 1.目前正在另一项试验性器械或药物研究中接受治疗，或结束另一项试验性器械或药物研究治疗≤30天", "label": 15, "label_text": "Enrollment in other studies", "id": "s7651"}
{"text": "</iii级）的患者；病程1-12个月。神志清楚、能予以配合治疗，接受穴位按摩、针灸疗法，穴位按摩及针灸部位无皮损；年龄60-80岁；自愿加入研究。&nbsp;<>", "label": 5, "label_text": "Multiple", "id": "s7652"}
{"text": "（5）经医院伦理委员会批准", "label": 43, "label_text": "Ethical Audit", "id": "s7653"}
{"text": "7. 符合临床研究伦理委员会要求。", "label": 43, "label_text": "Ethical Audit", "id": "s7654"}
{"text": "7 . 报告医院伦理委员会经批准后实行。", "label": 43, "label_text": "Ethical Audit", "id": "s7655"}
{"text": "通过医院伦理委员会审查批准手术。", "label": 43, "label_text": "Ethical Audit", "id": "s7656"}
{"text": "3、符合伦理要求", "label": 43, "label_text": "Ethical Audit", "id": "s7657"}
{"text": "6. 经医院伦理委员会批准。", "label": 43, "label_text": "Ethical Audit", "id": "s7658"}
{"text": "1.经过华中科技大学同济医学院附属同济医院伦理委员会的批准，", "label": 43, "label_text": "Ethical Audit", "id": "s7659"}
{"text": "6符合伦理要求", "label": 43, "label_text": "Ethical Audit", "id": "s7660"}
{"text": "4.研究方案经医院伦理委员会批准", "label": 43, "label_text": "Ethical Audit", "id": "s7661"}
{"text": "伦理委员会批准", "label": 43, "label_text": "Ethical Audit", "id": "s7662"}
{"text": "2）睡眠欠佳（每晚睡眠时间<4小时）", "label": 42, "label_text": "Bedtime", "id": "s7663"}
{"text": "睡眠正常", "label": 42, "label_text": "Bedtime", "id": "s7664"}
{"text": "包括失眠和／或过多的日间睡眠", "label": 42, "label_text": "Bedtime", "id": "s7665"}
{"text": "半年内规律、正常作息，每晚睡眠7-9小时左右", "label": 42, "label_text": "Bedtime", "id": "s7666"}
{"text": "3.作息规律，白天活动，夜间休息；", "label": 42, "label_text": "Bedtime", "id": "s7667"}
{"text": "每晚不晚于1 点睡觉，早上不早于6点起床。", "label": 42, "label_text": "Bedtime", "id": "s7668"}
{"text": "作息时间规律", "label": 42, "label_text": "Bedtime", "id": "s7669"}
{"text": "每晚睡眠7-9小时左右", "label": 42, "label_text": "Bedtime", "id": "s7670"}
{"text": "入睡困难", "label": 42, "label_text": "Bedtime", "id": "s7671"}
{"text": "睡眠情况良好，睡眠习惯规律", "label": 42, "label_text": "Bedtime", "id": "s7672"}
{"text": "存在肛交/口交性行为", "label": 37, "label_text": "Sexual related", "id": "s7673"}
{"text": "承诺在参加试验后四周不会发生任何无保护性的性行为", "label": 37, "label_text": "Sexual related", "id": "s7674"}
{"text": "有活动性异性性行为的男性", "label": 37, "label_text": "Sexual related", "id": "s7675"}
{"text": "性取向为同性或双性", "label": 37, "label_text": "Sexual related", "id": "s7676"}
{"text": "有性行为必须使用避孕套", "label": 37, "label_text": "Sexual related", "id": "s7677"}
{"text": "在治疗及随访期间停止性交", "label": 37, "label_text": "Sexual related", "id": "s7678"}
{"text": "发生过男男同性性行为", "label": 37, "label_text": "Sexual related", "id": "s7679"}
{"text": "同性行为（包括：手淫、口交、肛交）", "label": 37, "label_text": "Sexual related", "id": "s7680"}
{"text": "严重的性交困难", "label": 37, "label_text": "Sexual related", "id": "s7681"}
{"text": "发生无安全套的性交", "label": 37, "label_text": "Sexual related", "id": "s7682"}