GreatNorthCollective/greatnorth-canada-federal-laws-text huggingface dataset:
Hazardous Products Regulations — 8.5.1
Categories 8.5.1 A substance that is a germ cell mutagen is classified in a category or subcategory of this hazard class in accordance with the following table: TABLE Column 1 Column 2 Column 3 Item Category Subcategory Criteria 1 Germ Cell Mutagenicity — Category 1 Germ Cell Mutagenicity — Category 1A A substance that, according to data from human epidemiological studies, induces heritable mutations in germ cells 2 Germ Cell Mutagenicity — Category 1 Germ Cell Mutagenicity — Category 1B A substance in respect of which (a) data acquired from in vivo heritable germ cell mutagenicity tests in mammals demonstrate positive results; (b) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results and there is evidence that the substance has the potential to cause mutations to germ cells, such as (i) in germ cells, positive in vivo mutagenicity test results or positive in vivo genotoxicity test results, or (ii) evidence that the substance or any of its metabolites is able to interact with the genetic material of germ cells; or (c) data on human germ cells demonstrate mutagenic effects, with or without demonstrating transmission to offspring, including an increase in the frequency of aneuploidy in sperm of men exposed to the substance 3 Germ Cell Mutagenicity — Category 2 A substance in respect of which (a) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results; (b) data acquired from in vivo somatic cell genotoxicity tests demonstrate positive results and data acquired from in vitro mutagenicity tests demonstrate positive results; or (c) data acquired from in vitro mutagenicity tests in mammalian cells demonstrate positive results and the substance has a structure-activity relationship with germ cell mutagens classified in the subcategory “Germ Cell Mutagenicity — Category 1A”
Hazardous Products Regulations — (a)
A substance in respect of which (a) data acquired from in vivo heritable germ cell mutagenicity tests in mammals demonstrate positive results; (b) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results and there is evidence that the substance has the potential to cause mutations to germ cells, such as (i) in germ cells, positive in vivo mutagenicity test results or positive in vivo genotoxicity test results, or (ii) evidence that the substance or any of its metabolites is able to interact with the genetic material of germ cells; or (c) data on human germ cells demonstrate mutagenic effects, with or without demonstrating transmission to offspring, including an increase in the frequency of aneuploidy in sperm of men exposed to the substance
Hazardous Products Regulations — (a)
(a) data acquired from in vivo heritable germ cell mutagenicity tests in mammals demonstrate positive results;
Hazardous Products Regulations — (b)
(b) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results and there is evidence that the substance has the potential to cause mutations to germ cells, such as (i) in germ cells, positive in vivo mutagenicity test results or positive in vivo genotoxicity test results, or (ii) evidence that the substance or any of its metabolites is able to interact with the genetic material of germ cells; or
Hazardous Products Regulations — (i)
(i) in germ cells, positive in vivo mutagenicity test results or positive in vivo genotoxicity test results, or
Hazardous Products Regulations — (ii)
(ii) evidence that the substance or any of its metabolites is able to interact with the genetic material of germ cells; or
Hazardous Products Regulations — (c)
(c) data on human germ cells demonstrate mutagenic effects, with or without demonstrating transmission to offspring, including an increase in the frequency of aneuploidy in sperm of men exposed to the substance
Hazardous Products Regulations — (a)
A substance in respect of which (a) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results; (b) data acquired from in vivo somatic cell genotoxicity tests demonstrate positive results and data acquired from in vitro mutagenicity tests demonstrate positive results; or (c) data acquired from in vitro mutagenicity tests in mammalian cells demonstrate positive results and the substance has a structure-activity relationship with germ cell mutagens classified in the subcategory “Germ Cell Mutagenicity — Category 1A”
Hazardous Products Regulations — (a)
(a) data acquired from in vivo somatic cell mutagenicity tests in mammals demonstrate positive results;
Hazardous Products Regulations — (b)
(b) data acquired from in vivo somatic cell genotoxicity tests demonstrate positive results and data acquired from in vitro mutagenicity tests demonstrate positive results; or
Hazardous Products Regulations — (c)
(c) data acquired from in vitro mutagenicity tests in mammalian cells demonstrate positive results and the substance has a structure-activity relationship with germ cell mutagens classified in the subcategory “Germ Cell Mutagenicity — Category 1A”
Hazardous Products Regulations — 8.5.2
Order of provisions 8.5.2 The classification of a mixture as a germ cell mutagen in a category or subcategory of this hazard class must proceed in accordance with the order of sections 8.5.3 to 8.5.5.
Hazardous Products Regulations — 8.5.3
Ingredient classified in Category 1 or 1A 8.5.3 (1) A mixture is classified in the category “Germ Cell Mutagenicity — Category 1” or the subcategory “Germ Cell Mutagenicity — Category 1A” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Germ Cell Mutagenicity — Category 1A”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is a germ cell mutagen, in which case the mixture is classified as a germ cell mutagen in accordance with section 8.5.1; or (b) the mixture as a whole has been subjected to an in vivo heritable germ cell mutagenicity test that determines that the mixture is not a germ cell mutagen, and a scientifically validated method was used and the test was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out. Ingredient classified in Category 1 or 1B (2) A mixture is classified in the category “Germ Cell Mutagenicity — Category 1” or the subcategory “Germ Cell Mutagenicity — Category 1B” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Germ Cell Mutagenicity — Category 1B”, and does not contain any ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Germ Cell Mutagenicity — Category 1A”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is a germ cell mutagen, in which case the mixture is classified as a germ cell mutagen in accordance with section 8.5.1; or (b) the mixture as a whole has been subjected to an in vivo heritable germ cell mutagenicity test that determines that the mixture is not a germ cell mutagen, and a scientifically validated method was used and the test was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out. SOR/2022-272, s. 48
Hazardous Products Regulations — 8.5.4
Ingredient classified in Category 2 8.5.4 A mixture is classified in the category “Germ Cell Mutagenicity — Category 2” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 1.0% that is classified in the category “Germ Cell Mutagenicity — Category 2”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is a germ cell mutagen, in which case the mixture is classified as a germ cell mutagen in accordance with section 8.5.1; or (b) the mixture as a whole has been subjected to an in vivo heritable germ cell mutagenicity test that determines that the mixture is not a germ cell mutagen, and a scientifically validated method was used and the test was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out.
Hazardous Products Regulations — 8.5.5
Data available for use of bridging principles 8.5.5 If data are available to enable the characterization of the mixture as a germ cell mutagen, in accordance with the bridging principles referred to in subsections 2.3(3), (4) and (7), the mixture must be classified in accordance with those subsections.
Hazardous Products Regulations — 8.6
Definitions 8.6 The following definitions apply in this Subpart. carcinogenic means, in relation to a mixture or substance, liable to lead to cancer or to increase the incidence of cancer. ( cancérogène ) carcinogenicity means the production of cancer or an increase in the incidence of cancer occurring after exposure to a mixture or substance. ( cancérogénicité ) SOR/2022-272, s. 50
Hazardous Products Regulations — Hazardous Products Regulations
carcinogenic means, in relation to a mixture or substance, liable to lead to cancer or to increase the incidence of cancer. ( cancérogène )
Hazardous Products Regulations — Hazardous Products Regulations
carcinogenicity means the production of cancer or an increase in the incidence of cancer occurring after exposure to a mixture or substance. ( cancérogénicité )
Hazardous Products Regulations — 8.6.1
Categories 8.6.1 A carcinogenic substance is classified in a category or subcategory of this hazard class in accordance with the following table: TABLE Column 1 Column 2 Column 3 Item Category Subcategory Criteria 1 Carcinogenicity — Category 1 Carcinogenicity — Category 1A A substance in respect of which human data establish a causal relationship between exposure to the substance and the development of cancer 2 Carcinogenicity — Category 1 Carcinogenicity — Category 1B A substance in respect of which (a) human data establish a causal relationship between exposure to the substance and the development of cancer, but there are additional data that do not support, based on established scientific principles, the conclusion that the substance is the causative agent; (b) animal data establish a causal relationship between exposure to the substance and an increased incidence of malignant neoplasms or a combination of benign and malignant neoplasms in (i) two or more species of animals, as demonstrated by one or more studies, (ii) one species of animal, as demonstrated by two or more independent studies carried out at different times, in different laboratories or under different protocols, or (iii) one species of animal, as demonstrated by a single study, if the neoplasms observed in the study are, based on established scientific principles, atypical in relation to the incidence, site, type or age at onset for the species of animal under study; or (c) human data support a positive association between exposure to the substance and the development of cancer, and animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but the data supporting either positive association do not support a conclusion of a causal relationship, based on established scientific principles 3 Carcinogenicity — Category 2 A substance in respect of which (a) human data support a positive association between exposure to the substance and the development of cancer, but do not support a conclusion of a causal relationship, based on established scientific principles; or (b) animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but do not support a conclusion of a causal relationship, based on established scientific principles
Hazardous Products Regulations — (a)
A substance in respect of which (a) human data establish a causal relationship between exposure to the substance and the development of cancer, but there are additional data that do not support, based on established scientific principles, the conclusion that the substance is the causative agent; (b) animal data establish a causal relationship between exposure to the substance and an increased incidence of malignant neoplasms or a combination of benign and malignant neoplasms in (i) two or more species of animals, as demonstrated by one or more studies, (ii) one species of animal, as demonstrated by two or more independent studies carried out at different times, in different laboratories or under different protocols, or (iii) one species of animal, as demonstrated by a single study, if the neoplasms observed in the study are, based on established scientific principles, atypical in relation to the incidence, site, type or age at onset for the species of animal under study; or (c) human data support a positive association between exposure to the substance and the development of cancer, and animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but the data supporting either positive association do not support a conclusion of a causal relationship, based on established scientific principles
Hazardous Products Regulations — (a)
(a) human data establish a causal relationship between exposure to the substance and the development of cancer, but there are additional data that do not support, based on established scientific principles, the conclusion that the substance is the causative agent;
Hazardous Products Regulations — (b)
(b) animal data establish a causal relationship between exposure to the substance and an increased incidence of malignant neoplasms or a combination of benign and malignant neoplasms in (i) two or more species of animals, as demonstrated by one or more studies, (ii) one species of animal, as demonstrated by two or more independent studies carried out at different times, in different laboratories or under different protocols, or (iii) one species of animal, as demonstrated by a single study, if the neoplasms observed in the study are, based on established scientific principles, atypical in relation to the incidence, site, type or age at onset for the species of animal under study; or
Hazardous Products Regulations — (i)
(i) two or more species of animals, as demonstrated by one or more studies,
Hazardous Products Regulations — (ii)
(ii) one species of animal, as demonstrated by two or more independent studies carried out at different times, in different laboratories or under different protocols, or
Hazardous Products Regulations — (iii)
(iii) one species of animal, as demonstrated by a single study, if the neoplasms observed in the study are, based on established scientific principles, atypical in relation to the incidence, site, type or age at onset for the species of animal under study; or
Hazardous Products Regulations — (c)
(c) human data support a positive association between exposure to the substance and the development of cancer, and animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but the data supporting either positive association do not support a conclusion of a causal relationship, based on established scientific principles
Hazardous Products Regulations — (a)
A substance in respect of which (a) human data support a positive association between exposure to the substance and the development of cancer, but do not support a conclusion of a causal relationship, based on established scientific principles; or (b) animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but do not support a conclusion of a causal relationship, based on established scientific principles
Hazardous Products Regulations — (a)
(a) human data support a positive association between exposure to the substance and the development of cancer, but do not support a conclusion of a causal relationship, based on established scientific principles; or
Hazardous Products Regulations — (b)
(b) animal data support a positive association between exposure to the substance and an increased incidence of malignant or benign neoplasms, but do not support a conclusion of a causal relationship, based on established scientific principles
Hazardous Products Regulations — 8.6.2
Order of provisions 8.6.2 The classification of a mixture as a carcinogenic mixture in a category or subcategory of this hazard class must proceed in accordance with the order of sections 8.6.3 to 8.6.5.
Hazardous Products Regulations — 8.6.3
Ingredient classified in Category 1 or 1A 8.6.3 (1) A mixture is classified in the category “Carcinogenicity — Category 1” or the subcategory “Carcinogenicity — Category 1A” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Carcinogenicity — Category 1A”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is carcinogenic, in which case the mixture is classified as a carcinogenic mixture in accordance with section 8.6.1; or (b) the mixture as a whole has been subjected to a carcinogenicity study that determines that the mixture is not carcinogenic, and a scientifically validated method was used and the study was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out. Ingredient classified in Category 1 or 1B (2) A mixture is classified in the category “Carcinogenicity — Category 1” or the subcategory “Carcinogenicity — Category 1B” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Carcinogenicity — Category 1B”, and does not contain any ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Carcinogenicity — Category 1A”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is carcinogenic, in which case the mixture is classified as a carcinogenic mixture in accordance with section 8.6.1; or (b) the mixture as a whole has been subjected to a carcinogenicity study that determines that the mixture is not carcinogenic, and a scientifically validated method was used and the study was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out. SOR/2022-272, s. 51
Hazardous Products Regulations — 8.6.4
Ingredient classified in Category 2 8.6.4 A mixture is classified in the category “Carcinogenicity — Category 2” if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the category “Carcinogenicity — Category 2”, unless (a) there are data for the mixture as a whole that demonstrate conclusively, based on established scientific principles, that the mixture is carcinogenic, in which case the mixture is classified as a carcinogenic mixture in accordance with section 8.6.1; or (b) the mixture as a whole has been subjected to a carcinogenicity study that determines that the mixture is not carcinogenic, and a scientifically validated method was used and the study was performed in accordance with generally accepted standards of good scientific practice at the time it was carried out.
Hazardous Products Regulations — 8.6.5
Data available for use of bridging principles 8.6.5 If data are available to enable the characterization of the mixture as carcinogenic, in accordance with the bridging principles referred to in subsections 2.3(3), (4) and (7), the mixture must be classified in accordance with those subsections.
Hazardous Products Regulations — 8.7
Definitions 8.7 The following definitions apply in this Subpart. adverse effects on sexual function and fertility means any effect of a mixture or substance that is liable to interfere with sexual function or fertility, including (a) alterations to the female or male reproductive system; (b) adverse effects on onset of puberty, gamete production or transport, the reproductive cycle, sexual behaviour, parturition or pregnancy outcomes; (c) premature reproductive senescence; or (d) any modifications to other functions that are dependent on the integrity of the reproductive system. ( effets néfastes sur la fonction sexuelle et la fertilité ) adverse effects on the development of the embryo, fetus or offspring means any adverse effects of a mixture or substance on the embryo, fetus or offspring, resulting from exposure of either parent to the mixture or substance prior to conception or exposure of the developing embryo or fetus to the mixture or substance during prenatal development, or of the offspring during postnatal development to the time of sexual maturation, that is manifested at any point in the development of the embryo or fetus, or that is manifested at any point in the lifespan of the offspring, and that includes the loss of the embryo or fetus, death of the developing offspring, structural abnormality, altered growth and functional deficiency. This definition excludes the induction of genetically based inheritable effects in the offspring. ( effets néfastes sur le développement de l’embryon, du foetus ou de la progéniture ) effects on or via lactation means (a) any effect of a mixture or substance that interferes with lactation; or (b) the presence of the mixture or substance, or its metabolites, in the maternal milk in amounts for which there is evidence that supports the conclusion, based on established scientific principles, that the health of the breast-fed child or suckling animal is liable to be threatened. ( effets sur ou via l’allaitement ) reproductive toxicity refers to any of the following effects occurring after exposure to a mixture or substance: (a) adverse effects on sexual function and fertility; (b) adverse effects on the development of the embryo, fetus or offspring; or (c) effects on or via lactation. ( toxicité pour la reproduction ) toxic to reproduction means, in relation to a mixture or substance, liable to lead to reproductive toxicity. ( toxique pour la reproduction ) SOR/2022-272, s. 52
Hazardous Products Regulations — (a)
adverse effects on sexual function and fertility means any effect of a mixture or substance that is liable to interfere with sexual function or fertility, including (a) alterations to the female or male reproductive system; (b) adverse effects on onset of puberty, gamete production or transport, the reproductive cycle, sexual behaviour, parturition or pregnancy outcomes; (c) premature reproductive senescence; or (d) any modifications to other functions that are dependent on the integrity of the reproductive system. ( effets néfastes sur la fonction sexuelle et la fertilité )