GreatNorthCollective/greatnorth-canada-federal-laws-text huggingface dataset:
Hazardous Products Regulations — Hazardous Products Regulations
eye irritation means the production of changes in the eye after exposure of the eye to a mixture or substance that are fully reversible within an observation period of 21 days after that exposure. ( irritation oculaire )
Hazardous Products Regulations — (a)
serious eye damage means the production of tissue damage in the eye or serious physical decay of vision, occurring after exposure of the eye to a mixture or substance, (a) for which data demonstrate that it is irreversible; or (b) that is not fully reversible within an observation period of 21 days after that exposure. ( lésion oculaire grave )
Hazardous Products Regulations — 8.3.1
Order of provisions 8.3.1 The classification of a substance that causes serious eye damage or eye irritation in a category or subcategory of this hazard class must proceed in accordance with the order of sections 8.3.2 to 8.3.7, unless, after applying subsections 8.3.2(1) to (4), the substance is not classified further to subsection 8.3.2(5).
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, causes serious eye damage; (b) that, according to animal data acquired from a scientifically validated method from at least one animal, produces effects on the cornea, iris or conjunctiva (i) that are irreversible as demonstrated by data, or (ii) that are not fully reversible within an observation period of 21 days; or (c) in respect of which animal data acquired from tests performed in accordance with the OECD Guideline for the Testing of Chemicals, No. 405, entitled Acute Eye Irritation/Corrosion , as amended from time to time, demonstrate a positive response in at least two of three animals, and the mean score calculated following gradings at 24, 48 and 72 hours after instillation of the substance, is (i) in the case of corneal opacity, ≥ 3, or (ii) in the case of iritis, > 1.5
Hazardous Products Regulations — (a)
(a) that, according to human data, causes serious eye damage;
Hazardous Products Regulations — (b)
(b) that, according to animal data acquired from a scientifically validated method from at least one animal, produces effects on the cornea, iris or conjunctiva (i) that are irreversible as demonstrated by data, or (ii) that are not fully reversible within an observation period of 21 days; or
Hazardous Products Regulations — (i)
(i) that are irreversible as demonstrated by data, or
Hazardous Products Regulations — (ii)
(ii) that are not fully reversible within an observation period of 21 days; or
Hazardous Products Regulations — (c)
(c) in respect of which animal data acquired from tests performed in accordance with the OECD Guideline for the Testing of Chemicals, No. 405, entitled Acute Eye Irritation/Corrosion , as amended from time to time, demonstrate a positive response in at least two of three animals, and the mean score calculated following gradings at 24, 48 and 72 hours after instillation of the substance, is (i) in the case of corneal opacity, ≥ 3, or (ii) in the case of iritis, > 1.5
Hazardous Products Regulations — (i)
(i) in the case of corneal opacity, ≥ 3, or
Hazardous Products Regulations — (a)
A substance that is not classified in the category “Serious Eye Damage — Category 1” and in respect of which animal data acquired from tests performed in accordance with the OECD Guideline for the Testing of Chemicals, No. 405, entitled Acute Eye Irritation/Corrosion , as amended from time to time, demonstrate in at least two of three animals a positive response that fully reverses within an observation period of more than seven days but not more than 21 days, and the mean score calculated following gradings at 24, 48 and 72 hours after instillation of the substance, is (a) in the case of corneal opacity, ≥ 1; (b) in the case of iritis, ≥ 1; (c) in the case of conjunctival redness, ≥ 2; or (d) in the case of conjunctival edema (chemosis), ≥ 2
Hazardous Products Regulations — (a)
(a) in the case of corneal opacity, ≥ 1;
Hazardous Products Regulations — (c)
(c) in the case of conjunctival redness, ≥ 2; or
Hazardous Products Regulations — (d)
(d) in the case of conjunctival edema (chemosis), ≥ 2
Hazardous Products Regulations — (a)
A substance that is not classified in the category “Serious Eye Damage — Category 1” and in respect of which animal data acquired from tests performed in accordance with the OECD Guideline for the Testing of Chemicals, No. 405, entitled Acute Eye Irritation/Corrosion , as amended from time to time, demonstrate in at least two of three animals a positive response that fully reverses within an observation period of seven days, and the mean score calculated following gradings at 24, 48 and 72 hours after instillation of the substance, is (a) in the case of corneal opacity, ≥ 1; (b) in the case of iritis, ≥ 1; (c) in the case of conjunctival redness, ≥ 2; or (d) in the case of conjunctival edema (chemosis), ≥ 2
Hazardous Products Regulations — 8.3.3
Other animal data — eye or skin exposure 8.3.3 A substance for which there are animal data on eye exposure that demonstrate, or animal data on skin exposure that support the conclusion, that the substance causes serious eye damage or eye irritation is classified in the category “Serious Eye Damage — Category 1” or the category “Eye Irritation — Category 2”, and, in the latter case, if the applicable data are available, the substance is further classified in the subcategory “Eye Irritation — Category 2A” or in the subcategory “Eye Irritation — Category 2B”.
Hazardous Products Regulations — 8.3.4
In vitro or ex vivo data — serious eye damage 8.3.4 (1) A substance for which the data, in vitro or ex vivo , acquired from a scientifically validated method for the evaluation of serious eye damage demonstrate that the substance causes serious eye damage is classified in the category “Serious Eye Damage — Category 1”. In vitro or ex vivo data — eye irritation (2) A substance for which the data, in vitro or ex vivo , acquired from a scientifically validated method for the evaluation of eye irritation demonstrate that the substance causes eye irritation is classified in the category “Eye Irritation — Category 2” and, if the applicable data are available, the substance is further classified in the subcategory “Eye Irritation — Category 2A” or in the subcategory “Eye Irritation — Category 2B”.
Hazardous Products Regulations — 8.3.5
pH 8.3.5 A substance for which the pH is less than or equal to two or equal to or greater than 11.5 is classified in the category “Serious Eye Damage — Category 1”, unless an assessment of alkali or acid reserve performed in accordance with established scientific principles supports the conclusion that it need not be classified as a substance that causes serious eye damage on the basis of its pH.
Hazardous Products Regulations — 8.3.6
Structure-activity relationship — serious eye damage 8.3.6 (1) A substance for which a structure-activity relationship, established in accordance with established scientific principles, supports the conclusion that the substance must be classified in the category “Serious Eye Damage — Category 1” is classified in that category. Structure-activity relationship — eye irritation (2) A substance for which a structure-activity relationship, established in accordance with established scientific principles, supports the conclusion that the substance must be classified in the category “Eye Irritation — Category 2” is classified in that category and, if the applicable data are available, the substance is further classified in the subcategory “Eye Irritation — Category 2A” or in the subcategory “Eye Irritation — Category 2B”.
Hazardous Products Regulations — 8.3.7
Totality of available data 8.3.7 A substance for which an evaluation of the totality of available data, performed in accordance with established scientific principles, supports the conclusion that the substance causes serious eye damage or eye irritation is classified in the category “Serious Eye Damage — Category 1” or the category “Eye Irritation — Category 2” and, in the latter case, if the applicable data are available, the substance is further classified in the subcategory “Eye Irritation — Category 2A” or in the subcategory “Eye Irritation — Category 2B”.
Hazardous Products Regulations — 8.3.8
Order of provisions 8.3.8 The classification of a mixture as a mixture that causes serious eye damage or eye irritation in a category of this hazard class must proceed in accordance with the order of sections 8.3.9 to 8.3.11.
Hazardous Products Regulations — 8.3.9
Data available for mixture as a whole 8.3.9 (1) If data of the types referred to in subparagraphs 2.1(a)(i) to (iv) are available for the mixture as a whole, the mixture must be classified in accordance with the order of sections 8.3.2 to 8.3.7 unless, under subsection 8.3.2(5), the mixture need not be classified. Data available for mixture as a whole — sections 8.3.10 and 8.3.11 (2) If data of the types referred to in subparagraphs 2.1(a)(i) to (iv) are available for the mixture as a whole, but the mixture cannot be classified further to subsections 8.3.2(1) to (4) or sections 8.3.3 to 8.3.7, its classification in a category or subcategory of this hazard class must proceed in accordance with the order of sections 8.3.10 and 8.3.11.
Hazardous Products Regulations — 8.3.10
Data available for use of bridging principles 8.3.10 If data are available to enable the characterization of the mixture as a mixture that causes serious eye damage or eye irritation, in accordance with the bridging principles referred to in subsections 2.3(3) to (8), the mixture must be classified in a category or subcategory of this hazard class in accordance with those subsections.
Hazardous Products Regulations — 8.3.11
e Irritation — Category 2A”, and (iii) ingredients classified in the subcategory “Eye Irritation — Category 2B”; or (d) if the sum of the results of the following subparagraphs is equal to or greater than 10.0%, the mixture is classified in the category “Eye Irritation — Category 2”: (i) 10 times the total of the sum of concentrations of ingredients classified in the category “Serious Eye Damage — Category 1” and the sum of concentrations of ingredients classified in the category “Skin Corrosion — Category 1”, ingredients classified in the subcategory “Skin Corrosion — Category 1A”, ingredients classified in the subcategory “Skin Corrosion — Category 1B” and ingredients classified in the subcategory “Skin Corrosion — Category 1C”, and (ii) the sum of concentrations of ingredients classified in the category “Eye Irritation — Category 2”, ingredients classified in the subcategory “Eye Irritation — Category 2A” and ingredients classified in the subcategory “Eye Irritation — Category 2B”. Mixtures containing particular ingredients (3) A mixture is classified in a category of this hazard class in accordance with the following table if the mixture contains one or more substances, such as acids, bases, inorganic salts, aldehydes, phenols or surfactants, which could cause serious eye damage or eye irritation at concentrations below the concentration limits set out in subsection (2) and at least one ingredient with a concentration that is above the concentration limits set out below: TABLE Column 1 Column 2 Column 3 Item Category Ingredient Concentration Limits 1 Serious Eye Damage — Category 1 Acid with pH ≤ 2 ≥ 1.0% 2 Serious Eye Damage — Category 1 Base with pH ≥ 11.5 ≥ 1.0% 3 Serious Eye Damage — Category 1 Other ingredients classified in the category “Serious Eye Damage — Category 1” ≥ 1.0% 4 Eye Irritation — Category 2 Other ingredients classified in the category “Eye Irritation — Category 2”, including acids and bases ≥ 3.0% SOR/2022-272, s. 45
Hazardous Products Regulations — 8.4
Definitions 8.4 The following definitions apply in this Subpart. respiratory sensitization means the production of hypersensitivity of the airways occurring after inhalation of a mixture or substance. ( sensibilisation respiratoire ) respiratory sensitizer means a mixture or substance that is liable to lead to hypersensitivity of the airways following inhalation. ( sensibilisant respiratoire ) skin sensitization means the production of an allergic response occurring after skin contact with a mixture or substance. ( sensibilisation cutanée ) skin sensitizer means a mixture or substance that is liable to lead to an allergic response following skin contact. ( sensibilisant cutané ) SOR/2022-272, s. 46
Hazardous Products Regulations — Hazardous Products Regulations
respiratory sensitization means the production of hypersensitivity of the airways occurring after inhalation of a mixture or substance. ( sensibilisation respiratoire )
Hazardous Products Regulations — Hazardous Products Regulations
respiratory sensitizer means a mixture or substance that is liable to lead to hypersensitivity of the airways following inhalation. ( sensibilisant respiratoire )
Hazardous Products Regulations — Hazardous Products Regulations
skin sensitization means the production of an allergic response occurring after skin contact with a mixture or substance. ( sensibilisation cutanée )
Hazardous Products Regulations — Hazardous Products Regulations
skin sensitizer means a mixture or substance that is liable to lead to an allergic response following skin contact. ( sensibilisant cutané )
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to specific respiratory hypersensitivity; or (b) in respect of which animal data acquired from scientifically validated methods for the evaluation of respiratory sensitization demonstrate positive results
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to specific respiratory hypersensitivity; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of respiratory sensitization demonstrate positive results
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to a high frequency of occurrence of respiratory sensitization; or (b) in respect of which animal data support the probability of a high respiratory sensitization rate in humans
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to a high frequency of occurrence of respiratory sensitization; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data support the probability of a high respiratory sensitization rate in humans
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to a low to moderate frequency of occurrence of respiratory sensitization; or (b) in respect of which animal data support the probability of a low to moderate respiratory sensitization rate in humans
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to a low to moderate frequency of occurrence of respiratory sensitization; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data support the probability of a low to moderate respiratory sensitization rate in humans
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to skin sensitization; or (b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization demonstrate positive results
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to skin sensitization; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization demonstrate positive results
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to a high frequency of occurrence of skin sensitization; or (b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a high skin sensitization rate in humans
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to a high frequency of occurrence of skin sensitization; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a high skin sensitization rate in humans
Hazardous Products Regulations — (a)
A substance (a) that, according to human data, leads to a low to moderate frequency of occurrence of skin sensitization; or (b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a low to moderate skin sensitization rate in humans
Hazardous Products Regulations — (a)
(a) that, according to human data, leads to a low to moderate frequency of occurrence of skin sensitization; or
Hazardous Products Regulations — (b)
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a low to moderate skin sensitization rate in humans
Hazardous Products Regulations — 8.4.2
Order of provisions 8.4.2 The classification of a mixture as a respiratory sensitizer or a skin sensitizer, or both, in one or more categories of this hazard class must proceed in accordance with the order of sections 8.4.3 to 8.4.5.
Hazardous Products Regulations — 8.4.3
Data available for mixture as a whole 8.4.3 If data of the types referred to in subparagraphs 2.1(a)(i) to (iv) are available for the mixture as a whole, the mixture must be classified as a respiratory sensitizer or a skin sensitizer, or both, in accordance with section 8.4.1.
Hazardous Products Regulations — 8.4.4
Data available for use of bridging principles 8.4.4 If data are available to enable the characterization of the mixture as a respiratory sensitizer or a skin sensitizer, or both, in accordance with the bridging principles referred to in subsections 2.3(3) to (8), the mixture must be classified in a category of this hazard class in accordance with those subsections.
Hazardous Products Regulations — 8.4.5
Data available for ingredients 8.4.5 A mixture is classified as a respiratory sensitizer or as a skin sensitizer, or both, as the case may be, in accordance with the following: (a) as a respiratory sensitizer, (i) in the category “Respiratory Sensitizer — Category 1”, if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the category “Respiratory Sensitizer — Category 1”, (ii) in the subcategory “Respiratory Sensitizer — Category 1A”, if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Respiratory Sensitizer — Category 1A”, or (iii) in the subcategory “Respiratory Sensitizer — Category 1B”, if it does not contain ingredients classified in the subcategory “Respiratory Sensitizer — Category 1A” at a concentration equal to or greater than the concentration limit of 0.1% and (A) it contains at least one ingredient that is a solid or a liquid at a concentration equal to or greater than the concentration limit of 1.0% that is classified in the subcategory “Respiratory Sensitizer — Category 1B”, or (B) it contains at least one ingredient that is a gas at a concentration equal to or greater than the concentration limit of 0.2% that is classified in the subcategory “Respiratory Sensitizer — Category 1B”; or (b) as a skin sensitizer, (i) in the category “Skin Sensitizer — Category 1”, if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the category “Skin Sensitizer — Category 1”, (ii) in the subcategory “Skin Sensitizer — Category 1A”, if it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 0.1% that is classified in the subcategory “Skin Sensitizer — Category 1A”, or (iii) in the subcategory “Skin Sensitizer — Category 1B”, if it does not contain ingredients classified in the subcategory “Skin Sensitizer — Category 1A” at a concentration equal to or greater than the concentration limit of 0.1% and it contains at least one ingredient at a concentration equal to or greater than the concentration limit of 1.0% that is classified in the subcategory “Skin Sensitizer — Category 1B”.
Hazardous Products Regulations — 8.5
Definitions 8.5 The following definitions apply in this Subpart. genotoxicity means the alteration of the structure, information content or segregation of DNA by an agent or process, including those agents or processes that cause DNA damage by interfering with normal replication processes or that in a non-physiological manner temporarily alter its replication. ( génotoxicité ) germ cell mutagen means a mixture or substance that is liable to lead to an increased occurrence of mutations in the germ cells of a population. ( mutagène des cellules germinales ) germ cell mutagenicity means an increased occurrence of heritable gene mutations, including heritable structural and numerical chromosome aberrations in germ cells, occurring after exposure to a mixture or substance. ( mutagénicité sur les cellules germinales ) mutagenic means, in relation to a mixture or substance, liable to lead to an increased occurrence of mutations in populations of cells or organisms. ( mutagène ) mutagenicity means an increased occurrence of mutations in populations of cells or organisms. ( mutagénicité ) mutation means a permanent change in the amount or structure of the genetic material in a cell and includes (a) the heritable genetic changes that may be manifested at the phenotypic level; and (b) the underlying DNA modifications when known, including specific base pair changes and chromosomal translocations. ( mutation ) SOR/2022-272, s. 47
Hazardous Products Regulations — Hazardous Products Regulations
genotoxicity means the alteration of the structure, information content or segregation of DNA by an agent or process, including those agents or processes that cause DNA damage by interfering with normal replication processes or that in a non-physiological manner temporarily alter its replication. ( génotoxicité )
Hazardous Products Regulations — Hazardous Products Regulations
germ cell mutagen means a mixture or substance that is liable to lead to an increased occurrence of mutations in the germ cells of a population. ( mutagène des cellules germinales )
Hazardous Products Regulations — Hazardous Products Regulations
germ cell mutagenicity means an increased occurrence of heritable gene mutations, including heritable structural and numerical chromosome aberrations in germ cells, occurring after exposure to a mixture or substance. ( mutagénicité sur les cellules germinales )
Hazardous Products Regulations — Hazardous Products Regulations
mutagenic means, in relation to a mixture or substance, liable to lead to an increased occurrence of mutations in populations of cells or organisms. ( mutagène )
Hazardous Products Regulations — Hazardous Products Regulations
mutagenicity means an increased occurrence of mutations in populations of cells or organisms. ( mutagénicité )
Hazardous Products Regulations — (a)
mutation means a permanent change in the amount or structure of the genetic material in a cell and includes (a) the heritable genetic changes that may be manifested at the phenotypic level; and (b) the underlying DNA modifications when known, including specific base pair changes and chromosomal translocations. ( mutation )