Reference number : GC-2017-Q4-00686, amendment number : , agreement type : G, recipient legal name : Gouspillou, Gilles (Université du Québec à Montréal), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Morinda citrifolia, commonly known as noni, has been first introduced to the market by mid-1990's as a "super_x000D_
fruit". It has since been extensively studied for its anti-inflammatory, analgesic, antioxidant and anti-angiogenic_x000D_
properties. The trees grow in tropical climates especially in Hawaii, French Polynesia, Fiji, Costa Rica and_x000D_
Southeast Asia where they can reach up to 10 meters in height. To facilitate the farming and maximize their_x000D_
production, there are different companies in some countries (USA (Hawaii) and Costa Rica for example) that_x000D_
own plantations of noni trees. All over the year, to make the harvest of fruits easier for the workforce, farmers_x000D_
have to prune trees, leaving lots of leaves on the ground. The beneficial effects of the fruit properties for_x000D_
general health are well established. In contrast, the potential beneficial effects of extract prepared from the_x000D_
leaves, used as tea since centuries, have been poorly studied. It was recently shown that supplementing mice_x000D_
with an extract of noni leaves for 4 weeks resulted in an increased endurance and physical performance._x000D_
However, the mechanisms of action of these supplements remain unknown. Founded in 2004 and based in_x000D_
Rimouski (Québec), InnoVactiv is a Canadian company involved in the development and commercialization of_x000D_
bioactive ingredients from natural origin to serve the dietary supplement and cosmetic industries. InnoVactiv_x000D_
has recently secured an exclusive supply agreement with a Hawaiian company for dried noni leaves and_x000D_
developed an extraction method optimized to maximize the yield of the bioactive components of Noni leaves._x000D_
The specific problem of InnoVactiv is that its team does not have the knowledge, expertise and equipment to_x000D_
dissect the mechanisms responsible for the increased endurance and performance induced by the Noni leaves_x000D_
extract. This understanding will be critical for the company to further optimize the method of extraction and_x000D_
preserve the bioactive molecules responsible for its effect. To solve this problem, the company is partnering_x000D_
with Dr. Gouspillou, an expert in the field of muscle physiology and mitochondrial biology with access to a_x000D_
fully equipped laboratory to investigate the mechanisms of action of none leaves extract., program purpose french : Morinda citrifolia, commonly known as noni, has been first introduced to the market by mid-1990's as a "super_x000D_
fruit". It has since been extensively studied for its anti-inflammatory, analgesic, antioxidant and anti-angiogenic_x000D_
properties. The trees grow in tropical climates especially in Hawaii, French Polynesia, Fiji, Costa Rica and_x000D_
Southeast Asia where they can reach up to 10 meters in height. To facilitate the farming and maximize their_x000D_
production, there are different companies in some countries (USA (Hawaii) and Costa Rica for example) that_x000D_
own plantations of noni trees. All over the year, to make the harvest of fruits easier for the workforce, farmers_x000D_
have to prune trees, leaving lots of leaves on the ground. The beneficial effects of the fruit properties for_x000D_
general health are well established. In contrast, the potential beneficial effects of extract prepared from the_x000D_
leaves, used as tea since centuries, have been poorly studied. It was recently shown that supplementing mice_x000D_
with an extract of noni leaves for 4 weeks resulted in an increased endurance and physical performance._x000D_
However, the mechanisms of action of these supplements remain unknown. Founded in 2004 and based in_x000D_
Rimouski (Québec), InnoVactiv is a Canadian company involved in the development and commercialization of_x000D_
bioactive ingredients from natural origin to serve the dietary supplement and cosmetic industries. InnoVactiv_x000D_
has recently secured an exclusive supply agreement with a Hawaiian company for dried noni leaves and_x000D_
developed an extraction method optimized to maximize the yield of the bioactive components of Noni leaves._x000D_
The specific problem of InnoVactiv is that its team does not have the knowledge, expertise and equipment to_x000D_
dissect the mechanisms responsible for the increased endurance and performance induced by the Noni leaves_x000D_
extract. This understanding will be critical for the company to further optimize the method of extraction and_x000D_
preserve the bioactive molecules responsible for its effect. To solve this problem, the company is partnering_x000D_
with Dr. Gouspillou, an expert in the field of muscle physiology and mitochondrial biology with access to a_x000D_
fully equipped laboratory to investigate the mechanisms of action of none leaves extract., agreement title english : Mechanisms of action of biomolecules extracted from Morinda citrifolia leaves to improve endurance and physical performance, agreement title french : Mechanisms of action of biomolecules extracted from Morinda citrifolia leaves to improve endurance and physical performance, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-01-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada