Reference number : GC-2017-Q1-00247, amendment number : , agreement type : G, recipient legal name : Yang, Victor (Ryerson University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : In Radiotherapy, dosimetry and treatment planning are highly advanced for ionizing radiation._x000D_
Radiation dose is accurately defined and the relationship between it and_x000D_
clinical response is well understood. For photodynamic therapy (PDT), the definition of PDT_x000D_
dose is unclear and how it correlates with clinical response has yet to be precisely defined._x000D_
Present-day clinical protocols for PDT of non-melenoma skin cancer (NMSC) are relatively_x000D_
straight-forward: a photosensitizer is administered, a period of time elapses before shining_x000D_
light and then light with a specific fluence rate illuminates the patient. The same protocol is_x000D_
applied to an entire patient population and as a result, PDT of NMSC is conducted without_x000D_
detailed customized planning that takes into account patient to patient variability as practiced_x000D_
in radiotherapy. Our research goal is to work on in vivo measurement of optical properties and_x000D_
functional parameters such as oxygen levels together with measuring the temporal and_x000D_
spatial photosensitizer concentration uptake. With these quantitative metrics, the hope is that_x000D_
we will be able to model and predict the response of individual patients to PDT.. Better_x000D_
dosimetry will advance the development and utilization of PDT similar to radiation therapy_x000D_
where the field is very quantitative and evidence-based. Ultimately patient-specific planning of_x000D_
PDT treatment will increase NMSC clinical outcomes., program purpose french : In Radiotherapy, dosimetry and treatment planning are highly advanced for ionizing radiation._x000D_
Radiation dose is accurately defined and the relationship between it and_x000D_
clinical response is well understood. For photodynamic therapy (PDT), the definition of PDT_x000D_
dose is unclear and how it correlates with clinical response has yet to be precisely defined._x000D_
Present-day clinical protocols for PDT of non-melenoma skin cancer (NMSC) are relatively_x000D_
straight-forward: a photosensitizer is administered, a period of time elapses before shining_x000D_
light and then light with a specific fluence rate illuminates the patient. The same protocol is_x000D_
applied to an entire patient population and as a result, PDT of NMSC is conducted without_x000D_
detailed customized planning that takes into account patient to patient variability as practiced_x000D_
in radiotherapy. Our research goal is to work on in vivo measurement of optical properties and_x000D_
functional parameters such as oxygen levels together with measuring the temporal and_x000D_
spatial photosensitizer concentration uptake. With these quantitative metrics, the hope is that_x000D_
we will be able to model and predict the response of individual patients to PDT.. Better_x000D_
dosimetry will advance the development and utilization of PDT similar to radiation therapy_x000D_
where the field is very quantitative and evidence-based. Ultimately patient-specific planning of_x000D_
PDT treatment will increase NMSC clinical outcomes., agreement title english : Photodynamic therapy of non-melanoma skin cancers - development of a comprehensive image-guided planning system for personalized treatment, agreement title french : Photodynamic therapy of non-melanoma skin cancers - development of a comprehensive image-guided planning system for personalized treatment, agreement number : CHRPJ, agreement value : 253500.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada