Reference number : GC-2017-Q2-00368, amendment number : , agreement type : G, recipient legal name : Johnston, James (University of Saskatchewan), recipient country : CA, recipient province : nan, recipient city : Saskatchewan, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Hard to treat bacteria, particularly antibiotic-resistant bacteria, and associated infections impose a great burden_x000D_
on the Canadian healthcare system. SterileCare Inc. produces an antibacterial alternative to antibiotics which is_x000D_
effective against antibiotic-resistant bacteria. Their product, KiteLock solution, is approved Health Canada to_x000D_
decrease the risk of bacterial growth within catheters. To use KiteLock, users (nurses and patients) manually_x000D_
twist-off the end of a vial (which KiteLock is stored in), withdraw the solution from the vial into a disposable_x000D_
syringe, and then introduce the solution into the catheter. Currently, the vial is difficult to open due to the_x000D_
rigidity of the resin as well as the vial design. This is causing users to struggle with opening of the vial, causing_x000D_
fracture away from the intended break-off point, resulting in product waste and reduced market traction and_x000D_
credibility._x000D_
The overall goal of this NSERC Engage Grant is to aid SterileCare with production issues related to their_x000D_
KiteLock delivery system as well as investigate functionality and compatibility of other potential delivery_x000D_
systems (specifically existing syringes and catheters). To accomplish this goal, the main objectives are to: (1)_x000D_
develop computational finite element models of the current vial design to identify alternate designs for_x000D_
appropriate tip twist-off; (2) communicate with SterileCare and the contract manufacturer of the vials to_x000D_
produce and evaluate alternate designs; and (3) conduct mechanical testing of standard syringes and catheters_x000D_
when exposed to KiteLock solution._x000D_
The outcomes of this research will mitigate end-user frustration found with KiteLock, which will lead to_x000D_
more hospitals adopting the product. This will lead to reduced antibiotic use and a reduction of antibiotic_x000D_
resistance, two major health issues affecting Canadians. As well, this research will provide direction for_x000D_
alternate delivery systems. Further, trainees involved in this research will interact with industry and obtain_x000D_
training in medical device design., program purpose french : Hard to treat bacteria, particularly antibiotic-resistant bacteria, and associated infections impose a great burden_x000D_
on the Canadian healthcare system. SterileCare Inc. produces an antibacterial alternative to antibiotics which is_x000D_
effective against antibiotic-resistant bacteria. Their product, KiteLock solution, is approved Health Canada to_x000D_
decrease the risk of bacterial growth within catheters. To use KiteLock, users (nurses and patients) manually_x000D_
twist-off the end of a vial (which KiteLock is stored in), withdraw the solution from the vial into a disposable_x000D_
syringe, and then introduce the solution into the catheter. Currently, the vial is difficult to open due to the_x000D_
rigidity of the resin as well as the vial design. This is causing users to struggle with opening of the vial, causing_x000D_
fracture away from the intended break-off point, resulting in product waste and reduced market traction and_x000D_
credibility._x000D_
The overall goal of this NSERC Engage Grant is to aid SterileCare with production issues related to their_x000D_
KiteLock delivery system as well as investigate functionality and compatibility of other potential delivery_x000D_
systems (specifically existing syringes and catheters). To accomplish this goal, the main objectives are to: (1)_x000D_
develop computational finite element models of the current vial design to identify alternate designs for_x000D_
appropriate tip twist-off; (2) communicate with SterileCare and the contract manufacturer of the vials to_x000D_
produce and evaluate alternate designs; and (3) conduct mechanical testing of standard syringes and catheters_x000D_
when exposed to KiteLock solution._x000D_
The outcomes of this research will mitigate end-user frustration found with KiteLock, which will lead to_x000D_
more hospitals adopting the product. This will lead to reduced antibiotic use and a reduction of antibiotic_x000D_
resistance, two major health issues affecting Canadians. As well, this research will provide direction for_x000D_
alternate delivery systems. Further, trainees involved in this research will interact with industry and obtain_x000D_
training in medical device design., agreement title english : Mechanical evaluation of delivery systems for non-antibiotic antimicrobial solutions, agreement title french : Mechanical evaluation of delivery systems for non-antibiotic antimicrobial solutions, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada