Reference number : GC-2017-Q3-00618, amendment number : , agreement type : G, recipient legal name : Song, Jun (McGill University)|Song, Jun (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Today, clinical indicators of a possible bone fracture risk are vague - the current diagnostic criteria of_x000D_
osteoporosis leave the autonomy and life quality of millions of people to chance. This proposal aims to resolve_x000D_
the problem of characterization of spongy bone (most commonly affected by osteoporosis) based on clinical_x000D_
tomographic imaging. This will be the first time that a new set of architectural parameters of spongy_x000D_
(trabecular) bone derived from a 3D image are used to provide a reliable prognosis to osteoporosis patients, as_x000D_
opposed to the traditionally-used bone mineral density or bone volume parameters. The proposal is based on_x000D_
the recent discovery that healthy trabecular bone conforms to the topological principle of spanning maximal 3D_x000D_
volume with the minimal number of interconnected elements, akin to securing a sail mast to a boat deck with a_x000D_
few evenly spread ropes, rather than with the ropes pulling in one direction, or with a redundantly high number_x000D_
of ropes. This topological principle reflects the adaptation of bone for effective re-distribution of diverse loads_x000D_
and avoiding stress concentrations, both at the lowest metabolic cost. The topological descriptors of trabecular_x000D_
bone can be accessed via the novel inter-trabecular angle (ITA) analysis. This project will focus on detection_x000D_
and analysis of variation of the topological parameters in healthy and osteoporotic trabecular bone. We have_x000D_
preliminary evidence that such variation does exist and can be quantified. Following the definition of the range_x000D_
between topologically stable and unstable configurations of trabecular bone, simulation of clinical imaging will_x000D_
be carried out and an automated clinical application for medical tomography will be designed. The envisioned_x000D_
end result of this project will be an intuitive application ready for clinical validation and a supporting database_x000D_
of normal and pathological bone 3D images. This is especially relevant for developed countries where the_x000D_
high-longevity population succumbs to sedentary life style and metabolic diseases., program purpose french : Today, clinical indicators of a possible bone fracture risk are vague - the current diagnostic criteria of_x000D_
osteoporosis leave the autonomy and life quality of millions of people to chance. This proposal aims to resolve_x000D_
the problem of characterization of spongy bone (most commonly affected by osteoporosis) based on clinical_x000D_
tomographic imaging. This will be the first time that a new set of architectural parameters of spongy_x000D_
(trabecular) bone derived from a 3D image are used to provide a reliable prognosis to osteoporosis patients, as_x000D_
opposed to the traditionally-used bone mineral density or bone volume parameters. The proposal is based on_x000D_
the recent discovery that healthy trabecular bone conforms to the topological principle of spanning maximal 3D_x000D_
volume with the minimal number of interconnected elements, akin to securing a sail mast to a boat deck with a_x000D_
few evenly spread ropes, rather than with the ropes pulling in one direction, or with a redundantly high number_x000D_
of ropes. This topological principle reflects the adaptation of bone for effective re-distribution of diverse loads_x000D_
and avoiding stress concentrations, both at the lowest metabolic cost. The topological descriptors of trabecular_x000D_
bone can be accessed via the novel inter-trabecular angle (ITA) analysis. This project will focus on detection_x000D_
and analysis of variation of the topological parameters in healthy and osteoporotic trabecular bone. We have_x000D_
preliminary evidence that such variation does exist and can be quantified. Following the definition of the range_x000D_
between topologically stable and unstable configurations of trabecular bone, simulation of clinical imaging will_x000D_
be carried out and an automated clinical application for medical tomography will be designed. The envisioned_x000D_
end result of this project will be an intuitive application ready for clinical validation and a supporting database_x000D_
of normal and pathological bone 3D images. This is especially relevant for developed countries where the_x000D_
high-longevity population succumbs to sedentary life style and metabolic diseases., agreement title english : Clinical proxy for bone fracture risk in osteoporosis, agreement title french : Clinical proxy for bone fracture risk in osteoporosis, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada