Reference number : GC-2017-Q1-00245, amendment number : , agreement type : G, recipient legal name : Lane, Pierre (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : In Canada, lung cancer is the leading cause of cancer death accounting for over a quarter of_x000D_
all cancer deaths in men and women. The National Lung Screening Trial showed that lowdose_x000D_
spiral CT imaging can reduce cancer mortality by 20% in high-risk smokers compared to_x000D_
standard chest x-ray, primarily by detecting early stage cancer nodules, the majority of which_x000D_
are small (<9mm) and located in the lung periphery. For definitive lung cancer diagnosis and_x000D_
treatment planning, a physician must locate and sample suspected lung cancer nodules. The_x000D_
safest way to locate and sample lung nodules is using a bronchoscope; however, they are too_x000D_
large to access the small peripheral airways. We have recently pioneered a new fiber optic_x000D_
imaging catheter that is 0.9 mm in diameter that shows promise for locating peripheral lung_x000D_
nodules. This imaging modality, called optical coherence tomography  autofluorescence_x000D_
imaging (OCT-AFI) can image changes in the composition and structural features of lung_x000D_
tissue that occur in early lung cancer._x000D_
The goal of this proposal is 1) to further develop innovations to improve the resolution and_x000D_
contrast in OCT-AFI 2); to enable reflectance and narrow-band imaging via the same_x000D_
catheter; 3) to miniaturize the catheters further (<0.5mm) to allow access to even smaller_x000D_
airways; and 4) to develop methods for quantifying lung tissue features. These innovations_x000D_
should increase the ability to locate lung nodules in almost all areas of the lungs. This nextgeneration_x000D_
endoscopic imaging instrument will be tested in a small study population._x000D_
The research team comes from diverse backgrounds with extensive experience developing_x000D_
clinically proven optical imaging devices, and a wealth of clinical research history in the_x000D_
diagnosis and management of lung cancer. This research has great potential to affect clinical_x000D_
practice to improve patient care in Canada and worldwide by providing a sensitive and_x000D_
accurate instrument for locating early lung cancer._x000D_, program purpose french : In Canada, lung cancer is the leading cause of cancer death accounting for over a quarter of_x000D_
all cancer deaths in men and women. The National Lung Screening Trial showed that lowdose_x000D_
spiral CT imaging can reduce cancer mortality by 20% in high-risk smokers compared to_x000D_
standard chest x-ray, primarily by detecting early stage cancer nodules, the majority of which_x000D_
are small (<9mm) and located in the lung periphery. For definitive lung cancer diagnosis and_x000D_
treatment planning, a physician must locate and sample suspected lung cancer nodules. The_x000D_
safest way to locate and sample lung nodules is using a bronchoscope; however, they are too_x000D_
large to access the small peripheral airways. We have recently pioneered a new fiber optic_x000D_
imaging catheter that is 0.9 mm in diameter that shows promise for locating peripheral lung_x000D_
nodules. This imaging modality, called optical coherence tomography  autofluorescence_x000D_
imaging (OCT-AFI) can image changes in the composition and structural features of lung_x000D_
tissue that occur in early lung cancer._x000D_
The goal of this proposal is 1) to further develop innovations to improve the resolution and_x000D_
contrast in OCT-AFI 2); to enable reflectance and narrow-band imaging via the same_x000D_
catheter; 3) to miniaturize the catheters further (<0.5mm) to allow access to even smaller_x000D_
airways; and 4) to develop methods for quantifying lung tissue features. These innovations_x000D_
should increase the ability to locate lung nodules in almost all areas of the lungs. This nextgeneration_x000D_
endoscopic imaging instrument will be tested in a small study population._x000D_
The research team comes from diverse backgrounds with extensive experience developing_x000D_
clinically proven optical imaging devices, and a wealth of clinical research history in the_x000D_
diagnosis and management of lung cancer. This research has great potential to affect clinical_x000D_
practice to improve patient care in Canada and worldwide by providing a sensitive and_x000D_
accurate instrument for locating early lung cancer._x000D_, agreement title english : Endoscopic optical coherence tomography and autofluorescence imaging for early cancer detection, agreement title french : Endoscopic optical coherence tomography and autofluorescence imaging for early cancer detection, agreement number : CHRPJ, agreement value : 314004.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada