Reference number : GC-2017-Q4-00918, amendment number : , agreement type : G, recipient legal name : Kiarie, Elijah (University of Guelph), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Research and Development Grants - Project, program name french : Subventions de recherche et développement coopérative - projet, program purpose english : Poultry products are the most consumed animal proteins in Canada and contribute significantly to the national economy. To meet this demand, genetic selection and improvements in nutrition and management have led to dramatic increases in productivity and profitability of table egg laying hens and meat-type birds. On the downside, metabolic and skeletal disorders persist in commercial poultry production and the associated mortality and morbidity exerts huge economic losses to producers. There are two main concerns relating to skeletal disorders in poultry: (a) osteoporosis in egg-laying hens, and (b) leg disorders caused by rapid bone growth in broiler (meat-type) chickens. Furthermore, gastrointestinal adaptation to luminal environmental stress and resiliency to intensive production practices may represent rate-limiting step in genetic improvement for meat-type birds more so in the light of restriction on the use of antibiotic growth promoters (AGP). Omega-3 fatty acids (FA) such as EPA and DHA are known to play critical roles in the regulation of a variety of biological processes including development of vital organs such as skeleton, brain, gastrointestinal and engender transgenerational effects on development and behavior. The embryo to neonate transition is a critical period of development in poultry in which important genetic programs governing metabolism and growth are established. The potential of omega-3 FA in stimulating bone, brain, and immune cells development at embryonic through to early phases of chicks could significantly improve poultry productivity and welfare. Previous research in this area had focused on feeding omega-3 FA to adult birds to manage metabolic disorders, but limited research has investigated maternal feeding of omega-3 FA on epigenetic responses in the progeny. To address this gap in knowledge, series of studies will be conducted to explore epigenetic response of feeding broiler and egg strain pullet breeders omega-3 FA and subsequent effects on progeny skeletal, gut and behavioral development.  The research project will support training of 3 Ph.D and 2 undergraduate students, and a technician._x000D_
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_x000D_, program purpose french : Poultry products are the most consumed animal proteins in Canada and contribute significantly to the national economy. To meet this demand, genetic selection and improvements in nutrition and management have led to dramatic increases in productivity and profitability of table egg laying hens and meat-type birds. On the downside, metabolic and skeletal disorders persist in commercial poultry production and the associated mortality and morbidity exerts huge economic losses to producers. There are two main concerns relating to skeletal disorders in poultry: (a) osteoporosis in egg-laying hens, and (b) leg disorders caused by rapid bone growth in broiler (meat-type) chickens. Furthermore, gastrointestinal adaptation to luminal environmental stress and resiliency to intensive production practices may represent rate-limiting step in genetic improvement for meat-type birds more so in the light of restriction on the use of antibiotic growth promoters (AGP). Omega-3 fatty acids (FA) such as EPA and DHA are known to play critical roles in the regulation of a variety of biological processes including development of vital organs such as skeleton, brain, gastrointestinal and engender transgenerational effects on development and behavior. The embryo to neonate transition is a critical period of development in poultry in which important genetic programs governing metabolism and growth are established. The potential of omega-3 FA in stimulating bone, brain, and immune cells development at embryonic through to early phases of chicks could significantly improve poultry productivity and welfare. Previous research in this area had focused on feeding omega-3 FA to adult birds to manage metabolic disorders, but limited research has investigated maternal feeding of omega-3 FA on epigenetic responses in the progeny. To address this gap in knowledge, series of studies will be conducted to explore epigenetic response of feeding broiler and egg strain pullet breeders omega-3 FA and subsequent effects on progeny skeletal, gut and behavioral development.  The research project will support training of 3 Ph.D and 2 undergraduate students, and a technician._x000D_
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_x000D_, agreement title english : Nutritional approaches for enhancing productivity and welfare in poultry: epigenetic response to maternal feeding of omega-3 fatty acids, agreement title french : Nutritional approaches for enhancing productivity and welfare in poultry: epigenetic response to maternal feeding of omega-3 fatty acids, agreement number : CRDPJ, agreement value : 463315.0, agreement start date : 2018-02-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2021-2022)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2021-2022)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada