Reference number : GC-2017-Q3-00669, amendment number : , agreement type : G, recipient legal name : Lundgren, Rylan (University of Alberta), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Idea to Innovation, program name french : De l'idée à l'innovation, program purpose english : The pharmaceutical and fine chemical sectors must prepare diverse, complex small molecules in a resource efficient manner. Consistent with this endeavor, our research group has established a series of chemical processes for the rapid construction of high-value organic compounds. Our novel strategy forms carbon-carbon bonds from stable and abundant precursors (aryl boronic acid and carboxylic acid derivatives) using a copper mediator or catalyst. Exceptionally mild conditions are enabled by the in situ regeneration of the copper promoter by oxygen in ambient air. This new methodology has been used to prepare polyfunctionalized chemical building blocks and to diversify drug molecules. In order to ensure uptake of the process by commercial partners and to expand our IP landscape we aim to: 1) demonstrate this method in the synthesis of pharmaceutically relevant, molecular substructures; 2) confirm the scalability/robustness of the process to deliver tens to hundreds of grams of product; 3) identify new catalysts that promote improved reactivity and scope at reduced metal-loadings; 4) further develop collaboration and licensing relationships with partners in the pharmaceutical/custom synthesis/chemical manufacturing sectors., program purpose french : The pharmaceutical and fine chemical sectors must prepare diverse, complex small molecules in a resource efficient manner. Consistent with this endeavor, our research group has established a series of chemical processes for the rapid construction of high-value organic compounds. Our novel strategy forms carbon-carbon bonds from stable and abundant precursors (aryl boronic acid and carboxylic acid derivatives) using a copper mediator or catalyst. Exceptionally mild conditions are enabled by the in situ regeneration of the copper promoter by oxygen in ambient air. This new methodology has been used to prepare polyfunctionalized chemical building blocks and to diversify drug molecules. In order to ensure uptake of the process by commercial partners and to expand our IP landscape we aim to: 1) demonstrate this method in the synthesis of pharmaceutically relevant, molecular substructures; 2) confirm the scalability/robustness of the process to deliver tens to hundreds of grams of product; 3) identify new catalysts that promote improved reactivity and scope at reduced metal-loadings; 4) further develop collaboration and licensing relationships with partners in the pharmaceutical/custom synthesis/chemical manufacturing sectors., agreement title english : Copper-catalyzed oxidative carbon-carbon bond forming processes, agreement title french : Copper-catalyzed oxidative carbon-carbon bond forming processes, agreement number : I2IPJ, agreement value : 125000.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada