Reference number : GC-2017-Q3-00485, amendment number : , agreement type : G, recipient legal name : Sanati Nezhad, Amir (University of Calgary), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Immunosensors are very known among different types of biosensors for rapid diagnosis of biomarkers in bodily_x000D_
fluids. The label-format of immunosensors allows for flexible implementation of biosensing in a wide range of_x000D_
detection schemes. However, these systems are limited in very high sensitive detection of minutes of molecules_x000D_
in complex biological samples. There is also a trade-off in the time, cost and additional steps associated with_x000D_
incorporating reporter molecules into the label-based process. Moreover, the use of optical detection systems in_x000D_
point-of-care devices has one more constraint in detection of multiple biomarkers simultaneously in a single_x000D_
multiplexed biosensor as they require an external light source, optical transducer and other optical components_x000D_
like lenses and reflectors, which makes the detection system bulky and complex. Among various types of_x000D_
label-free detection techniques, the electrochemical sensing is the simplest to integrate, highly sensitive and_x000D_
more compatible with multiplexing and integration into microfluidics, which makes it ideal for point-of-care_x000D_
diagnosis._x000D_
In this work, we will develop an integrated and autonomous microfluidic-based biosensor for rapid detection of_x000D_
brain injury biomarkers. A new bonding technology will be developed to adhere electrodes to microfluidic_x000D_
layers noninvasively to enable efficient performance of electrodes and point-of-care detection of biomarkers. If_x000D_
successful, the microfluidic nano-biosensor proposed in this work will be used for rapid diagnosis of three_x000D_
different biomarkers of brain injury in blood samples of patients in less than an hour. The expertise of the_x000D_
applicant in microfluidics and biosensors ensures the success of this project._x000D_
Sensoreal Inc. will benefit from label-free biosensors to extend the application of their technology for rapid and_x000D_
automated detection of multiple biomarkers in human biological samples using a point-of-care diagnostic_x000D_
technology. The lower cost and predictive point of care sensors will enable the rapid and large scale disease_x000D_
screening and facilitate monitoring the efficacy of therapeutics, therefore benefit the health system in Canada., program purpose french : Immunosensors are very known among different types of biosensors for rapid diagnosis of biomarkers in bodily_x000D_
fluids. The label-format of immunosensors allows for flexible implementation of biosensing in a wide range of_x000D_
detection schemes. However, these systems are limited in very high sensitive detection of minutes of molecules_x000D_
in complex biological samples. There is also a trade-off in the time, cost and additional steps associated with_x000D_
incorporating reporter molecules into the label-based process. Moreover, the use of optical detection systems in_x000D_
point-of-care devices has one more constraint in detection of multiple biomarkers simultaneously in a single_x000D_
multiplexed biosensor as they require an external light source, optical transducer and other optical components_x000D_
like lenses and reflectors, which makes the detection system bulky and complex. Among various types of_x000D_
label-free detection techniques, the electrochemical sensing is the simplest to integrate, highly sensitive and_x000D_
more compatible with multiplexing and integration into microfluidics, which makes it ideal for point-of-care_x000D_
diagnosis._x000D_
In this work, we will develop an integrated and autonomous microfluidic-based biosensor for rapid detection of_x000D_
brain injury biomarkers. A new bonding technology will be developed to adhere electrodes to microfluidic_x000D_
layers noninvasively to enable efficient performance of electrodes and point-of-care detection of biomarkers. If_x000D_
successful, the microfluidic nano-biosensor proposed in this work will be used for rapid diagnosis of three_x000D_
different biomarkers of brain injury in blood samples of patients in less than an hour. The expertise of the_x000D_
applicant in microfluidics and biosensors ensures the success of this project._x000D_
Sensoreal Inc. will benefit from label-free biosensors to extend the application of their technology for rapid and_x000D_
automated detection of multiple biomarkers in human biological samples using a point-of-care diagnostic_x000D_
technology. The lower cost and predictive point of care sensors will enable the rapid and large scale disease_x000D_
screening and facilitate monitoring the efficacy of therapeutics, therefore benefit the health system in Canada., agreement title english : Novel microfluidic electrochemical biosensor for rapid diagnosis of biomarkers, agreement title french : Novel microfluidic electrochemical biosensor for rapid diagnosis of biomarkers, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-11-08, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada