Reference number : GC-2017-Q4-01322, amendment number : , agreement type : G, recipient legal name : Murshed, Monzur (McGill University)|Murshed, Monzur (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Recent advances in gene manipulation techniques have opened up new opportunities for the treatment of_x000D_
hereditary diseases. Although remarkable progresses have been made in the development of the potential tools_x000D_
which can be used for gene editing in the living organisms, the methods to deliver these tools (e.g. foreign_x000D_
DNA molecules) inside the cells are still under-developed. In the current proposal we will use a needle-free_x000D_
delivery system invented by a Canadian company that uses air pressure to deliver medicine deep inside the_x000D_
tissue. We will develop methodologies to deliver combination of DNA-chemical mixtures inside the cells. The_x000D_
combination of high air pressure together with DNA-chemical complexes has not been tried before. If_x000D_
successful, this novel approach will expand the use of the existing system making it an essential tool in modern_x000D_
biomedical research. This will not only benefit the research community, but also create scopes to expand the_x000D_
business of the company and eventual contribution to Canadian Economy., program purpose french : Recent advances in gene manipulation techniques have opened up new opportunities for the treatment of_x000D_
hereditary diseases. Although remarkable progresses have been made in the development of the potential tools_x000D_
which can be used for gene editing in the living organisms, the methods to deliver these tools (e.g. foreign_x000D_
DNA molecules) inside the cells are still under-developed. In the current proposal we will use a needle-free_x000D_
delivery system invented by a Canadian company that uses air pressure to deliver medicine deep inside the_x000D_
tissue. We will develop methodologies to deliver combination of DNA-chemical mixtures inside the cells. The_x000D_
combination of high air pressure together with DNA-chemical complexes has not been tried before. If_x000D_
successful, this novel approach will expand the use of the existing system making it an essential tool in modern_x000D_
biomedical research. This will not only benefit the research community, but also create scopes to expand the_x000D_
business of the company and eventual contribution to Canadian Economy., agreement title english : Novel method of in vivo gene delivery using a needle-free system, agreement title french : Novel method of in vivo gene delivery using a needle-free system, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada