Reference number : GC-2017-Q3-00652, amendment number : , agreement type : G, recipient legal name : White, Aaron (University of Saskatchewan), recipient country : CA, recipient province : nan, recipient city : Saskatchewan, recipient postal code : nan, program name english : Engage Plus Grants for universities, program name french : Subvention d'engagement partenarial Plus pour les universités, program purpose english : Today more than ever before, new alternatives to antibiotics are needed to control infectious diseases, as_x000D_
important pathogens are becoming increasingly resistant. Microorganisms can also grow in different ways that_x000D_
makes them inherently tough to eradicate. Biofilms are a mode of growth where individual cells aggregate and_x000D_
become embedded in a resistant and protective extracellular matrix. Many livestock and human infectious_x000D_
diseases can be thought of as biofilm-related and often different microorganisms can be part of the same_x000D_
biofilm. In a previous NSERC Engage grant, we worked with SterileCare Inc., a Canadian biotechnology_x000D_
company that has developed a new antimicrobial agent. In the current project, we are proposing to develop a_x000D_
multi-species biofilm model that more closely approximates natural conditions. Modern bacterial tagging_x000D_
technology will be used to visualize and enumerate the biofilms, and we will test the killing ability of the_x000D_
Sterile Care product either administered alone or in concert with other non-antibiotic treatments. We will_x000D_
explore the mechanisms of action of the products and work to identify treatment conditions that will lead to_x000D_
improved intellectual property for the company. SterileCare Inc. hopes to further develop a powerful agent to_x000D_
treat both human and veterinary conditions associated with biofilms and multidrug resistant microorganisms,_x000D_
which falls in line with global Antibiotic Stewardship efforts., program purpose french : Today more than ever before, new alternatives to antibiotics are needed to control infectious diseases, as_x000D_
important pathogens are becoming increasingly resistant. Microorganisms can also grow in different ways that_x000D_
makes them inherently tough to eradicate. Biofilms are a mode of growth where individual cells aggregate and_x000D_
become embedded in a resistant and protective extracellular matrix. Many livestock and human infectious_x000D_
diseases can be thought of as biofilm-related and often different microorganisms can be part of the same_x000D_
biofilm. In a previous NSERC Engage grant, we worked with SterileCare Inc., a Canadian biotechnology_x000D_
company that has developed a new antimicrobial agent. In the current project, we are proposing to develop a_x000D_
multi-species biofilm model that more closely approximates natural conditions. Modern bacterial tagging_x000D_
technology will be used to visualize and enumerate the biofilms, and we will test the killing ability of the_x000D_
Sterile Care product either administered alone or in concert with other non-antibiotic treatments. We will_x000D_
explore the mechanisms of action of the products and work to identify treatment conditions that will lead to_x000D_
improved intellectual property for the company. SterileCare Inc. hopes to further develop a powerful agent to_x000D_
treat both human and veterinary conditions associated with biofilms and multidrug resistant microorganisms,_x000D_
which falls in line with global Antibiotic Stewardship efforts., agreement title english : Developing a multi-species biofilm model for testing novel antimicrobials, agreement title french : Developing a multi-species biofilm model for testing novel antimicrobials, agreement number : EGP2, agreement value : 12500.0, agreement start date : 2017-12-13, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada