Reference number : GC-2017-Q2-00442, amendment number : , agreement type : G, recipient legal name : Derda, Ratmir (University of Alberta), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Peptide based therapeutics make up a significant portion of the current armory we have against diseases and_x000D_
illnesses. However, unmodified peptides are not suitable as drugs because of their poor chemical and physical_x000D_
stability, short circulating plasma half-life, and limited oral bioavailability. To circumvent these disadvantages,_x000D_
a significant amount of effort has been put forward to chemically modify unprotected peptides. These_x000D_
modifications add valuable characteristics such as enhanced cell permeability, increased stability to proteases,_x000D_
increased oral bioavailability, extended lifetime in the blood serum, improved specificity and conformational_x000D_
rigidity to augment potency. Currently, robust rapid modification of unprotected peptide protocols are limited_x000D_
to solely academic laboratory use. Industry-scale syntheses of peptide derivatives are not common. With the_x000D_
growing need in peptide-based therapeutics, TC Scientific Inc. aims to develop a peptide modification protocol_x000D_
that is suitable for industry level production. The Derda Lab at the University of Alberta has extensive_x000D_
experience in robust rapid modification of unprotected peptides in water using readily available modifiers. By_x000D_
combining the academic advantage of the Derda group and the industry experience from TC scientific Inc., the_x000D_
goal of this proposal is to develop robust industrial peptide modification protocols., program purpose french : Peptide based therapeutics make up a significant portion of the current armory we have against diseases and_x000D_
illnesses. However, unmodified peptides are not suitable as drugs because of their poor chemical and physical_x000D_
stability, short circulating plasma half-life, and limited oral bioavailability. To circumvent these disadvantages,_x000D_
a significant amount of effort has been put forward to chemically modify unprotected peptides. These_x000D_
modifications add valuable characteristics such as enhanced cell permeability, increased stability to proteases,_x000D_
increased oral bioavailability, extended lifetime in the blood serum, improved specificity and conformational_x000D_
rigidity to augment potency. Currently, robust rapid modification of unprotected peptide protocols are limited_x000D_
to solely academic laboratory use. Industry-scale syntheses of peptide derivatives are not common. With the_x000D_
growing need in peptide-based therapeutics, TC Scientific Inc. aims to develop a peptide modification protocol_x000D_
that is suitable for industry level production. The Derda Lab at the University of Alberta has extensive_x000D_
experience in robust rapid modification of unprotected peptides in water using readily available modifiers. By_x000D_
combining the academic advantage of the Derda group and the industry experience from TC scientific Inc., the_x000D_
goal of this proposal is to develop robust industrial peptide modification protocols., agreement title english : Development of robust industrial protocols for the synthesis of peptide derivatives, agreement title french : Development of robust industrial protocols for the synthesis of peptide derivatives, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada