Reference number : GC-2017-Q2-00433, amendment number : , agreement type : G, recipient legal name : Weber, John (Memorial University of Newfoundland), recipient country : CA, recipient province : nan, recipient city : Newfoundland and Labrador|Terre-Neuve-et-Labrador, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Ocean Pride Fisheries Limited is a company that specializes in sea cucumber-based products and is very_x000D_
interested in the pursuit of advanced research into these products along with the development of novel_x000D_
nutraceuticals. My research group has studied species of berries for several years and has found neuroprotective_x000D_
effects of various extracts from the fruits and leaves of these plants. The goal of the current project is to_x000D_
develop and test a new sea cucumber-based nutraceutical product combined with blueberry extracts. Sea_x000D_
cucumbers are excellent sources of dietary antioxidants, however to our knowledge there are no studies on the_x000D_
effects of sea cucumber extracts on nervous system tissue. This project aims to find an optimal combination of_x000D_
sea cucumber and blueberry extracts for the formulation of a novel and effective nutraceutical product that has_x000D_
the potential to counteract the effects of brain aging and neuroinflammation, which may contribute to various_x000D_
brain disorders. We will measure antioxidant capacity and other biochemical parameters in various blends of_x000D_
sea cucumber and blueberry extracts. We will then test these blended extract preparations in cell culture_x000D_
models, which mimic neurotoxicity, in order to detect potential neuroprotective effects. This project can be_x000D_
completed within a six month time period, therefore producing rapid results for the company. The described_x000D_
experiments and analysis will aid in discovering a novel nutraceutical based on sea cucumber and blueberry_x000D_
extracts. The scientific validation of the new sea cucumber-based nutraceutical will be extremely useful to the_x000D_
marketing of these products in Canada and beyond, and to the development of future products. This would_x000D_
have a positive economic impact, especially for Atlantic Canada in particular., program purpose french : Ocean Pride Fisheries Limited is a company that specializes in sea cucumber-based products and is very_x000D_
interested in the pursuit of advanced research into these products along with the development of novel_x000D_
nutraceuticals. My research group has studied species of berries for several years and has found neuroprotective_x000D_
effects of various extracts from the fruits and leaves of these plants. The goal of the current project is to_x000D_
develop and test a new sea cucumber-based nutraceutical product combined with blueberry extracts. Sea_x000D_
cucumbers are excellent sources of dietary antioxidants, however to our knowledge there are no studies on the_x000D_
effects of sea cucumber extracts on nervous system tissue. This project aims to find an optimal combination of_x000D_
sea cucumber and blueberry extracts for the formulation of a novel and effective nutraceutical product that has_x000D_
the potential to counteract the effects of brain aging and neuroinflammation, which may contribute to various_x000D_
brain disorders. We will measure antioxidant capacity and other biochemical parameters in various blends of_x000D_
sea cucumber and blueberry extracts. We will then test these blended extract preparations in cell culture_x000D_
models, which mimic neurotoxicity, in order to detect potential neuroprotective effects. This project can be_x000D_
completed within a six month time period, therefore producing rapid results for the company. The described_x000D_
experiments and analysis will aid in discovering a novel nutraceutical based on sea cucumber and blueberry_x000D_
extracts. The scientific validation of the new sea cucumber-based nutraceutical will be extremely useful to the_x000D_
marketing of these products in Canada and beyond, and to the development of future products. This would_x000D_
have a positive economic impact, especially for Atlantic Canada in particular., agreement title english : Development of a novel nutraceutical product, agreement title french : Development of a novel nutraceutical product, agreement number : EGP, agreement value : 24100.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada