Reference number : GC-2017-Q4-00287, amendment number : , agreement type : G, recipient legal name : Cant, John (University of Guelph), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Research and Development Grants - Project, program name french : Subventions de recherche et développement coopérative - projet, program purpose english : Due to improvements in computer models that predict rates of absorption of amino acids by dairy cows based on a description of their diet, there are new opportunities to exploit the functional aspects of amino acid nutrition, outside the scope of meeting requirements as building blocks of proteins. Studies in other animals have shown that amino acids exert a range of diverse influences on physiology and metabolism and it is not unreasonable to expect that amino acids can similarly affect signalling and gene expression in the mammary glands of dairy cows. Our objectives are to characterize the functional and molecular responses to specific amino acids in terms of protein and fat synthesis in mammary cells in culture (objective 1), in mammary tissue of lactating rats (objective 2) and cows (objective 3), and then to incorporate equations describing milk composition responses to amino acids into the industrial partner's ration evaluation model that will be used to formulate dietary amino acid profiles to achieve a desired milk component response (objective 4). The revised model and knowledge gained from the project will be used by Nutreco Canada Inc. to optimize lactational performance of cows in client herds and improve the sustainability and security of milk production in Canada. The project will employ ½ postdoctoral fellow, a graduate student, and 2 undergraduate students._x000D_
_x000D_, program purpose french : Due to improvements in computer models that predict rates of absorption of amino acids by dairy cows based on a description of their diet, there are new opportunities to exploit the functional aspects of amino acid nutrition, outside the scope of meeting requirements as building blocks of proteins. Studies in other animals have shown that amino acids exert a range of diverse influences on physiology and metabolism and it is not unreasonable to expect that amino acids can similarly affect signalling and gene expression in the mammary glands of dairy cows. Our objectives are to characterize the functional and molecular responses to specific amino acids in terms of protein and fat synthesis in mammary cells in culture (objective 1), in mammary tissue of lactating rats (objective 2) and cows (objective 3), and then to incorporate equations describing milk composition responses to amino acids into the industrial partner's ration evaluation model that will be used to formulate dietary amino acid profiles to achieve a desired milk component response (objective 4). The revised model and knowledge gained from the project will be used by Nutreco Canada Inc. to optimize lactational performance of cows in client herds and improve the sustainability and security of milk production in Canada. The project will employ ½ postdoctoral fellow, a graduate student, and 2 undergraduate students._x000D_
_x000D_, agreement title english : Functional roles of amino acids in regulation of milk fat and protein synthesis, agreement title french : Functional roles of amino acids in regulation of milk fat and protein synthesis, agreement number : CRDPJ, agreement value : 83000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2019-2020)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2019-2020)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada