Reference number : GC-2017-Q4-00661, amendment number : , agreement type : G, recipient legal name : Ghosh, Raja (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Bio-therapeutics such as monoclonal antibodies which are widely used for treating life-threatening ailments are_x000D_
currently manufactured by mammalian cell culture. Large-scale production using mammalian cell culture is_x000D_
technically challenging and expensive. Bio-pharming, i.e. expression of therapeutic proteins in plant is a novel,_x000D_
scalable, safe, economical, environment -friendly and promising alternative to mammalian cell culture._x000D_
PlantForm Corporation is an Ontario based bio-pharming company with an established track record in_x000D_
manufacturing tobacco based bio-therapeutics. The company recognises that feedstock pre-treatment before_x000D_
product purification could significantly affect the efficiency of the purification process. Such pre-treatment will_x000D_
target the removal of impurities such as RUBISCO and pigments present in tobacco extract using novel_x000D_
membrane technology developed in the applicant's research group. Removing these key impurities through_x000D_
pre-treatment step is expected to increase the overall purification efficiency and contribute towards increased_x000D_
product purity and recovery, and lowering of manufacturing cost., program purpose french : Bio-therapeutics such as monoclonal antibodies which are widely used for treating life-threatening ailments are_x000D_
currently manufactured by mammalian cell culture. Large-scale production using mammalian cell culture is_x000D_
technically challenging and expensive. Bio-pharming, i.e. expression of therapeutic proteins in plant is a novel,_x000D_
scalable, safe, economical, environment -friendly and promising alternative to mammalian cell culture._x000D_
PlantForm Corporation is an Ontario based bio-pharming company with an established track record in_x000D_
manufacturing tobacco based bio-therapeutics. The company recognises that feedstock pre-treatment before_x000D_
product purification could significantly affect the efficiency of the purification process. Such pre-treatment will_x000D_
target the removal of impurities such as RUBISCO and pigments present in tobacco extract using novel_x000D_
membrane technology developed in the applicant's research group. Removing these key impurities through_x000D_
pre-treatment step is expected to increase the overall purification efficiency and contribute towards increased_x000D_
product purity and recovery, and lowering of manufacturing cost., agreement title english : Pre-treatment of plant extracts for enhancing recovery and purification of high-value bio-therapeutics, agreement title french : Pre-treatment of plant extracts for enhancing recovery and purification of high-value bio-therapeutics, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-02-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada