Reference number : GC-2017-Q1-00251, amendment number : , agreement type : G, recipient legal name : Schreiner, John (Queen’s University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Modern radiation therapy has advanced through the development of techniques to better_x000D_
shape radiation dose to tumour volumes while minimizing adverse dose effects to surrounding_x000D_
normal tissue. In brachytherapy (Greek: near therapy) radiation sources are placed into the_x000D_
tumour under robotic control. Placing a dose detector near the radiation source affects dose_x000D_
in adjacent regions. For this reason, dose delivery validation in brachytherapy is usually_x000D_
based on quality assurance of very simple geometries that are not as complex as those_x000D_
clinically encountered during patient treatments._x000D_
A promising technique for dose measurement is gel dosimetry which is based on imaging_x000D_
special gel systems which change when irradiated. The changes can be imaged with various_x000D_
techniques available to our laboratory and provide the spatial distribution of the dose. The_x000D_
gels mimic tissue and so the dose measured corresponds to the dose to a patient. As a result,_x000D_
dose measurement is more accurate and we can validate a planned delivery for a given_x000D_
patient before treatment starts._x000D_
We propose to: i) test current gel formulations for their effectiveness and shortcomings in_x000D_
brachytherapy dosimetry and create, characterize and test new formulations designed_x000D_
specifically for brachytherapy applications; ii) develop standard protocols and phantoms_x000D_
specific to brachytherapy dose delivery; and, iii) develop software to evaluate and compare_x000D_
gel-measured doses to measurements using conventional tools and to planned dose delivery._x000D_
Testing of planned delivery is performed daily in other radiation therapy delivery with x-ray_x000D_
machines but is not yet available for brachytherapy. We will be the first to develop patient_x000D_
specific dose delivery validation for brachytherapy., program purpose french : Modern radiation therapy has advanced through the development of techniques to better_x000D_
shape radiation dose to tumour volumes while minimizing adverse dose effects to surrounding_x000D_
normal tissue. In brachytherapy (Greek: near therapy) radiation sources are placed into the_x000D_
tumour under robotic control. Placing a dose detector near the radiation source affects dose_x000D_
in adjacent regions. For this reason, dose delivery validation in brachytherapy is usually_x000D_
based on quality assurance of very simple geometries that are not as complex as those_x000D_
clinically encountered during patient treatments._x000D_
A promising technique for dose measurement is gel dosimetry which is based on imaging_x000D_
special gel systems which change when irradiated. The changes can be imaged with various_x000D_
techniques available to our laboratory and provide the spatial distribution of the dose. The_x000D_
gels mimic tissue and so the dose measured corresponds to the dose to a patient. As a result,_x000D_
dose measurement is more accurate and we can validate a planned delivery for a given_x000D_
patient before treatment starts._x000D_
We propose to: i) test current gel formulations for their effectiveness and shortcomings in_x000D_
brachytherapy dosimetry and create, characterize and test new formulations designed_x000D_
specifically for brachytherapy applications; ii) develop standard protocols and phantoms_x000D_
specific to brachytherapy dose delivery; and, iii) develop software to evaluate and compare_x000D_
gel-measured doses to measurements using conventional tools and to planned dose delivery._x000D_
Testing of planned delivery is performed daily in other radiation therapy delivery with x-ray_x000D_
machines but is not yet available for brachytherapy. We will be the first to develop patient_x000D_
specific dose delivery validation for brachytherapy., agreement title english : Gel dosimetry for brachytherapy dose delivery validation, agreement title french : Gel dosimetry for brachytherapy dose delivery validation, agreement number : CHRPJ, agreement value : 157870.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada