Reference number : GC-2017-Q3-00455, amendment number : , agreement type : G, recipient legal name : Wright, David (University of Guelph), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposing_x000D_
factor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producers_x000D_
of > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented and_x000D_
managed through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibited_x000D_
during the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis can_x000D_
be prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate a_x000D_
number of times through the intestines, damaging the organ in the process. Damage to the intestine results in_x000D_
inflammation and reductions in markers of gut integrity that have been linked to decreases in weight gain_x000D_
following vaccination. Feed additives that promote proper intestinal functioning may prove beneficial in_x000D_
mitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by Trouw_x000D_
Nutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids._x000D_
Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feed_x000D_
conversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, the_x000D_
mechanistic underpinnings of these effects have not been elucidated. This is an important question to address,_x000D_
as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce the_x000D_
economic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like to_x000D_
investigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinal_x000D_
inflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer this_x000D_
question and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal will_x000D_
provide important insight into the mechanisms of action of ElrM and will be an important step in expanding_x000D_
the use of ElrM in other species., program purpose french : Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposing_x000D_
factor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producers_x000D_
of > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented and_x000D_
managed through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibited_x000D_
during the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis can_x000D_
be prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate a_x000D_
number of times through the intestines, damaging the organ in the process. Damage to the intestine results in_x000D_
inflammation and reductions in markers of gut integrity that have been linked to decreases in weight gain_x000D_
following vaccination. Feed additives that promote proper intestinal functioning may prove beneficial in_x000D_
mitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by Trouw_x000D_
Nutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids._x000D_
Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feed_x000D_
conversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, the_x000D_
mechanistic underpinnings of these effects have not been elucidated. This is an important question to address,_x000D_
as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce the_x000D_
economic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like to_x000D_
investigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinal_x000D_
inflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer this_x000D_
question and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal will_x000D_
provide important insight into the mechanisms of action of ElrM and will be an important step in expanding_x000D_
the use of ElrM in other species., agreement title english : The effects of Selko Elarom Poultry on intestinal inflammation in broiler chickens, agreement title french : The effects of Selko Elarom Poultry on intestinal inflammation in broiler chickens, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-12-13, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada