Reference number : GC-2017-Q3-00475, amendment number : , agreement type : G, recipient legal name : Bertrand, Nicolas (Université Laval), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Folia Biotech is a clinical-stage nanomedicine company working in the field of immunotherapy using_x000D_
nanoparticles derived from papaya mosaic virus. En route toward clinical validation of their platform_x000D_
technology, they require further information on the blood circulation profile and biodistribution of their lead_x000D_
product._x000D_
This proposal will be divided into two parts: 1) establishing a robust labeling method allowing tracking of their_x000D_
nanoparticles in complex biological samples and 2) evaluating the circulation and biodistribution profiles of_x000D_
their proprietary technology. Together, these objectives will allow Folia to acquire the methods necessary to_x000D_
further understand how their nanoparticle interact with biological environments. This project will offer_x000D_
technical knowledge and fundamental toxicology understanding. This will create value surrounding the_x000D_
proprietary technology, and foster the interest of pharmaceutical companies for collaborations._x000D_
The academic lab involved in this project possesses accredited excellence in the labelling of nanoparticles and_x000D_
the evaluation of their circulation profiles. By advancing the development of a nanomedicine technology that_x000D_
can be used for vaccination and immunotherapy, this project will create value for Canada, and contribute to the_x000D_
training of highly qualified personnel., program purpose french : Folia Biotech is a clinical-stage nanomedicine company working in the field of immunotherapy using_x000D_
nanoparticles derived from papaya mosaic virus. En route toward clinical validation of their platform_x000D_
technology, they require further information on the blood circulation profile and biodistribution of their lead_x000D_
product._x000D_
This proposal will be divided into two parts: 1) establishing a robust labeling method allowing tracking of their_x000D_
nanoparticles in complex biological samples and 2) evaluating the circulation and biodistribution profiles of_x000D_
their proprietary technology. Together, these objectives will allow Folia to acquire the methods necessary to_x000D_
further understand how their nanoparticle interact with biological environments. This project will offer_x000D_
technical knowledge and fundamental toxicology understanding. This will create value surrounding the_x000D_
proprietary technology, and foster the interest of pharmaceutical companies for collaborations._x000D_
The academic lab involved in this project possesses accredited excellence in the labelling of nanoparticles and_x000D_
the evaluation of their circulation profiles. By advancing the development of a nanomedicine technology that_x000D_
can be used for vaccination and immunotherapy, this project will create value for Canada, and contribute to the_x000D_
training of highly qualified personnel., agreement title english : Analytical methods and analysis of in vivo toxicology of nanoparticles derived from the papaya-mosaic virus., agreement title french : Analytical methods and analysis of in vivo toxicology of nanoparticles derived from the papaya-mosaic virus., agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada