Reference number : GC-2017-Q3-00312, amendment number : , agreement type : G, recipient legal name : Desbiens, André (Université Laval), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Collaborative Research and Development Grants - Project, program name french : Subventions de recherche et développement coopérative - projet, program purpose english : Even if remarkable progress has been recently achieved, the manufacturing efficiency of the pharmaceutical industry still lags behind that of most other industries. Automation and continuous processing is a way to become more competitive, to reduce production time, energy consumption and the amount of waste produced. Indeed, better sensors and closed-loop feedback control system enable the transition toward a more desirable quality by design-based, rather than quality by testing-based, manufacturing of the next generation of pharmaceutical products. They also reduce process variability and operator errors and lead to a better understanding of the process._x000D_
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The objective is to increase the automation of three processes that present mass and heat exchanges:_x000D_
- Coating of the tablets: development of a in-line vision sensor providing film-coating properties (coating level, distribution across tablets esthetical defects, etc.)._x000D_
- Drying of the granules (before they are compressed into tablets): safe and robust in-line minimization of the drying time and/or energy consumption._x000D_
- Freeze-drying of vials: safe and robust in-line minimization of the drying time and/or energy consumption._x000D_
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The algorithms will be developped using first principles modelling and simulations, experimental data and in-line tests on pilot plants. _x000D_
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The tools and knowledge of flexible manufacturing developed during this project will help Pfizer Montreal to position itself as a global research and development centre for new and innovative manufacturing technologies for the entire Pfizer manufacturing network._x000D_
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_x000D_, program purpose french : Even if remarkable progress has been recently achieved, the manufacturing efficiency of the pharmaceutical industry still lags behind that of most other industries. Automation and continuous processing is a way to become more competitive, to reduce production time, energy consumption and the amount of waste produced. Indeed, better sensors and closed-loop feedback control system enable the transition toward a more desirable quality by design-based, rather than quality by testing-based, manufacturing of the next generation of pharmaceutical products. They also reduce process variability and operator errors and lead to a better understanding of the process._x000D_
_x000D_
The objective is to increase the automation of three processes that present mass and heat exchanges:_x000D_
- Coating of the tablets: development of a in-line vision sensor providing film-coating properties (coating level, distribution across tablets esthetical defects, etc.)._x000D_
- Drying of the granules (before they are compressed into tablets): safe and robust in-line minimization of the drying time and/or energy consumption._x000D_
- Freeze-drying of vials: safe and robust in-line minimization of the drying time and/or energy consumption._x000D_
_x000D_
The algorithms will be developped using first principles modelling and simulations, experimental data and in-line tests on pilot plants. _x000D_
_x000D_
The tools and knowledge of flexible manufacturing developed during this project will help Pfizer Montreal to position itself as a global research and development centre for new and innovative manufacturing technologies for the entire Pfizer manufacturing network._x000D_
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_x000D_, agreement title english : Pharmaceutical manufacturing: automation of heat and mass transfer processes, agreement title french : Pharmaceutical manufacturing: automation of heat and mass transfer processes, agreement number : CRDPJ, agreement value : 281651.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2020-2021)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2020-2021)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada