Reference number : GC-2017-Q1-00455, amendment number : , agreement type : G, recipient legal name : Morin, Sylvie (York University)|Morin, Sylvie (Université York), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Production of vaccine product formulation requires large investments before their commercialization. Success_x000D_
in these endeavours results in investment returns for the companies producing them and large impact on_x000D_
population health and longevity. Most vaccine produced today are targeting more than one virus. The_x000D_
formulation is complex and involves the addition of adjuvants that are substances that are shown to boost our_x000D_
response to a given vaccine drug. In this context, some vaccines do not display the expected immune response._x000D_
This maybe linked to the extend of antigens adsorption on the adjuvant, which was shown to be linked to a_x000D_
vaccine immunogenicity. In this project we are interested in the characterization of the adjuvant morphology_x000D_
and surface chemistry and to link this to its ability to adsorbed antigens. This information would allow to assess_x000D_
how reproducible is the adjuvant surface and to explore ways to tailor its surface chemistry to ensure optimum_x000D_
adjuvant performances. In this work we will use x-ray photoelectron spectroscopy, Raman and FTIR_x000D_
spectroscopy, as well as scanning electron microscopy to understand the state of the adjuvant surface under_x000D_
different conditions. Various activation process as well as chemical treatments will be use to modify the_x000D_
adjuvant surface and monitor its adsorption properties toward selected antigens. The ultimate goal is to develop_x000D_
a methodology to perform relevant quality control on the produced adjuvant prior to its use in vaccine_x000D_
formulation., program purpose french : Production of vaccine product formulation requires large investments before their commercialization. Success_x000D_
in these endeavours results in investment returns for the companies producing them and large impact on_x000D_
population health and longevity. Most vaccine produced today are targeting more than one virus. The_x000D_
formulation is complex and involves the addition of adjuvants that are substances that are shown to boost our_x000D_
response to a given vaccine drug. In this context, some vaccines do not display the expected immune response._x000D_
This maybe linked to the extend of antigens adsorption on the adjuvant, which was shown to be linked to a_x000D_
vaccine immunogenicity. In this project we are interested in the characterization of the adjuvant morphology_x000D_
and surface chemistry and to link this to its ability to adsorbed antigens. This information would allow to assess_x000D_
how reproducible is the adjuvant surface and to explore ways to tailor its surface chemistry to ensure optimum_x000D_
adjuvant performances. In this work we will use x-ray photoelectron spectroscopy, Raman and FTIR_x000D_
spectroscopy, as well as scanning electron microscopy to understand the state of the adjuvant surface under_x000D_
different conditions. Various activation process as well as chemical treatments will be use to modify the_x000D_
adjuvant surface and monitor its adsorption properties toward selected antigens. The ultimate goal is to develop_x000D_
a methodology to perform relevant quality control on the produced adjuvant prior to its use in vaccine_x000D_
formulation., agreement title english : Identification of key parameters in adjuvant efficiency, agreement title french : Identification of key parameters in adjuvant efficiency, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada