Reference number : GC-2017-Q4-00029, amendment number : , agreement type : G, recipient legal name : Akbari, Mohsen (University of Victoria), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The demand for organ repair and transplantation, and a shortage of available donors necessitates the clinical_x000D_
need to develop innovative treatment strategies for long-term repair and regeneration of injured or diseased_x000D_
tissues and organs. 3D printing is a process used to construct 3D objects by relying on the layer-by-layer_x000D_
deposition of materials onto a computer-controlled build platform. Bioprinting combines 3D printing_x000D_
technology, cell biology, and materials science, by coupling the build platform with a device that enables the_x000D_
deposition of bioinks. Bioprinting technology is adaptive to a wide range of biomaterials (i.e., synthetic and_x000D_
natural polymers, blood-derived proteins, and de-cellularized extracellular matrix (ECM)), accommodating the_x000D_
growth and proliferation of various cell sources, including stem cells and somatic cells. Aspect Biosystems'_x000D_
proprietary Lab-on-PrinterTM technology utilizes the concept of coaxial-flow focusing to deposit cell-laden_x000D_
biological fibers layer-by-layer and form 3D tissue-like constructs. Aspect Biosystems is planning to extend_x000D_
their Bioink library to include photo-crosslinkable materials including gelatin methacryloyl (GelMA) and_x000D_
polyethylene glycol diacrylate (PEGDA). Lab-on- a-PrinterTM technology is compatible with a range of low_x000D_
and medium viscosity Bioinks that are particularly well suited to promoting tissue function due to a_x000D_
combination of favorable mechanical properties and high ratios of bioactive and cellular content to scaffold_x000D_
components. Using these materials can significantly improve the printing resolution which will lead to better_x000D_
control on the micro- and macrostructure of the fabricated scaffolds. The overarching goals of this Engage_x000D_
project are to modify the current printhead cartridges to print photo-crosslinkable gelatin as a widely used_x000D_
biomaterial in the tissue engineering community. We will perform a systematic characterization study to_x000D_
develop a protocol for the fabrication of photo-crosslinkable hydrogel constructs. Cells will be loaded in the_x000D_
fabricated constructs to evaluate the biocompatibility of the process., program purpose french : The demand for organ repair and transplantation, and a shortage of available donors necessitates the clinical_x000D_
need to develop innovative treatment strategies for long-term repair and regeneration of injured or diseased_x000D_
tissues and organs. 3D printing is a process used to construct 3D objects by relying on the layer-by-layer_x000D_
deposition of materials onto a computer-controlled build platform. Bioprinting combines 3D printing_x000D_
technology, cell biology, and materials science, by coupling the build platform with a device that enables the_x000D_
deposition of bioinks. Bioprinting technology is adaptive to a wide range of biomaterials (i.e., synthetic and_x000D_
natural polymers, blood-derived proteins, and de-cellularized extracellular matrix (ECM)), accommodating the_x000D_
growth and proliferation of various cell sources, including stem cells and somatic cells. Aspect Biosystems'_x000D_
proprietary Lab-on-PrinterTM technology utilizes the concept of coaxial-flow focusing to deposit cell-laden_x000D_
biological fibers layer-by-layer and form 3D tissue-like constructs. Aspect Biosystems is planning to extend_x000D_
their Bioink library to include photo-crosslinkable materials including gelatin methacryloyl (GelMA) and_x000D_
polyethylene glycol diacrylate (PEGDA). Lab-on- a-PrinterTM technology is compatible with a range of low_x000D_
and medium viscosity Bioinks that are particularly well suited to promoting tissue function due to a_x000D_
combination of favorable mechanical properties and high ratios of bioactive and cellular content to scaffold_x000D_
components. Using these materials can significantly improve the printing resolution which will lead to better_x000D_
control on the micro- and macrostructure of the fabricated scaffolds. The overarching goals of this Engage_x000D_
project are to modify the current printhead cartridges to print photo-crosslinkable gelatin as a widely used_x000D_
biomaterial in the tissue engineering community. We will perform a systematic characterization study to_x000D_
develop a protocol for the fabrication of photo-crosslinkable hydrogel constructs. Cells will be loaded in the_x000D_
fabricated constructs to evaluate the biocompatibility of the process., agreement title english : A microfluidic printhead for printing photo-cross linkable hydrogels, agreement title french : A microfluidic printhead for printing photo-cross linkable hydrogels, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada