Reference number : GC-2017-Q2-00130, amendment number : , agreement type : G, recipient legal name : Kadoury, Samuel (École Polytechnique de Montréal), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : With its high incidence rate (1 in 7 men), prostate cancer is the second leading cause of cancer death in men in_x000D_
North America. Towards this end, high-dose-rate (HDR) brachytherapy offers the ability to treat prostate_x000D_
cancer with a dose-modulated approach for optimized clinical performance, while avoiding sensitive zones that_x000D_
might interfere with the patient's well-being. The industrial partner, Elekta Ltd, is specialized in radiotherapy_x000D_
and radioactive brachytherapy systems used for focal treatments in patients with breast, lung, liver or prostate_x000D_
cancer. A key advantage of the technology developed by Elekta is the integration of pre-operative imaging to_x000D_
create a dose-plan and treat the tumor based on the patient's MRI, adapting the dose modulation during the_x000D_
treatment phase. However a major limitation in the widespread use of HDR brachytherapy resides in the_x000D_
involuntary movement or local deformation of the prostate gland during the intervention. Indeed, these_x000D_
radiotherapy systems depend on accurate tracking of the tumor during radiation treatment, which can be highly_x000D_
influenced bu the deformation of the prostate. This can cause possible toxicity of local therapy to surrounding_x000D_
tissue and increase the risk of local persistence or recurrence. The goal of this project is to develop a_x000D_
computerized tool which will measure the deformation induced in the prostate based on computer vision and_x000D_
machine learning approaches, ultimately compensating the deformation during image-guided treatments. This_x000D_
project will have the following objectives: (1) Create an interface to load the pre-operative (MRI) and_x000D_
intra-operative acquisitions (3D ultrasound or MRI); (2) Implement a 3D shape modelling tool of the prostate;_x000D_
(3) Compute a 4D deformation field, by developing a prostate registration algorithm using a non-parametric_x000D_
diffeomorphic approach; (4) Clinical validation to verify prostate deformation between pre-operative and_x000D_
intra-operative acquisitions. A major impact of this work will be to enable tissue deformation analysis in an_x000D_
interventional environment for precise dose-painting in combination with multiparametric MR imaging,_x000D_
potentially reducing recurrence and minimizing the risk that normal prostate is excessively irradiated., program purpose french : With its high incidence rate (1 in 7 men), prostate cancer is the second leading cause of cancer death in men in_x000D_
North America. Towards this end, high-dose-rate (HDR) brachytherapy offers the ability to treat prostate_x000D_
cancer with a dose-modulated approach for optimized clinical performance, while avoiding sensitive zones that_x000D_
might interfere with the patient's well-being. The industrial partner, Elekta Ltd, is specialized in radiotherapy_x000D_
and radioactive brachytherapy systems used for focal treatments in patients with breast, lung, liver or prostate_x000D_
cancer. A key advantage of the technology developed by Elekta is the integration of pre-operative imaging to_x000D_
create a dose-plan and treat the tumor based on the patient's MRI, adapting the dose modulation during the_x000D_
treatment phase. However a major limitation in the widespread use of HDR brachytherapy resides in the_x000D_
involuntary movement or local deformation of the prostate gland during the intervention. Indeed, these_x000D_
radiotherapy systems depend on accurate tracking of the tumor during radiation treatment, which can be highly_x000D_
influenced bu the deformation of the prostate. This can cause possible toxicity of local therapy to surrounding_x000D_
tissue and increase the risk of local persistence or recurrence. The goal of this project is to develop a_x000D_
computerized tool which will measure the deformation induced in the prostate based on computer vision and_x000D_
machine learning approaches, ultimately compensating the deformation during image-guided treatments. This_x000D_
project will have the following objectives: (1) Create an interface to load the pre-operative (MRI) and_x000D_
intra-operative acquisitions (3D ultrasound or MRI); (2) Implement a 3D shape modelling tool of the prostate;_x000D_
(3) Compute a 4D deformation field, by developing a prostate registration algorithm using a non-parametric_x000D_
diffeomorphic approach; (4) Clinical validation to verify prostate deformation between pre-operative and_x000D_
intra-operative acquisitions. A major impact of this work will be to enable tissue deformation analysis in an_x000D_
interventional environment for precise dose-painting in combination with multiparametric MR imaging,_x000D_
potentially reducing recurrence and minimizing the risk that normal prostate is excessively irradiated., agreement title english : Prostate deformation analysis during ultrasound-guided radiotherapy procedures with transformative models, agreement title french : Prostate deformation analysis during ultrasound-guided radiotherapy procedures with transformative models, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-07-12, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada