Reference number : 172-2024-2025-Q2-1021483, amendment number : , agreement type : G, recipient legal name : Governors of St Francis Xavier University, recipient country : CA, recipient province : NS, recipient city : Antigonish|Antigonish, recipient postal code : B2G 2W5, program name english : Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives, program name french : Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D, program purpose english : Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas., program purpose french : Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires., agreement title english : Effects of nano/microplastic exposure on zebrafish (Danio rerio) gut microbiome, agreement title french : Effets de l’exposition aux nano/microplastiques sur le microbiome intestinal du poisson zèbre (Danio rerio), agreement number : 1021483, agreement value : 88384.0, agreement start date : 2024-09-01, agreement end date : 2024-08-31, description english : Plastic pollution is a worldwide problem. As plastic pollution is expected to grow, the amount of plastic in the environment is also expected to grow. Plastic pieces found in the environment are categorized depending on their size: microplastics (MP) (1-5000 µm) and nanoplastics (NP) (1-1000 nm). 
Both micro and nanoplastics can have deleterious effects when ingested by organisms in the environment. Observed effects varies from food dilution, oxidative stress and lower reproductive success. Additionally, more and more research is done on organisms microbiome. Once ingested, microplastics are mainly accumulating in the gastro-intestinal tract before being egested with feces and only a small portion will reach other organs. In the case of nanoplastics, due to their small sizes, they can cross biological barriers and can be distributed within all organs. As the gastro-intestinal tract is where both micro and nanoplastic transit through, these particles can have potential effects on the gastro-intestinal tract itself but also on the microbiome inhabitating it. Additionally, some research found that nanoplastics can disrupt the brain-intestine-microbiota axis, and call for this endpoint to be studied when assessing the environmental risk of micro and nanoplastics. To study the effects of micro and nanoplastics on gut microbiota, we propose to use adult zebrafish (Danio rerio) as a model species., description french : Effets de l’exposition aux nano/microplastiques sur le microbiome intestinal du poisson zèbre (Danio rerio), expected results english : In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems., expected results french : À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides., additional information english : nan, additional information french : nan, owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada