Reference number : 172-2022-2023-Q2-996027, amendment number : 1, agreement type : G, recipient legal name : The University of British Columbia, recipient country : CA, recipient province : BC, recipient city : Vancouver|Vancouver, recipient postal code : V6T 1Z3, program name english : Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives, program name french : Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D, program purpose english : Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas., program purpose french : Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires., agreement title english : Clinical CAR-T cell raman spectroscopy analysis, agreement title french : Analyse clinique par spectroscopie Raman des cellules CAR-T, agreement number : 996027, agreement value : 217397.0, agreement start date : 2022-08-01, agreement end date : 2025-03-31, description english : The approval of chimeric antigen receptor T-cell (CAR-T) therapies has been a major breakthrough for patients with relapsed or refractory blood cancers. However, CAR-T cells are highly complex, live cell therapies, and it has proven difficult to predict CAR-T cell potency. Great improvements in laser and detector technologies have led to an explosive growth in biomedical applications of Raman spectroscopy (RS), including leading contributions by this group. RS measures the macromolecular changes in T cells that are phenotypical of their activation state and other changes. The objective of this project is to contribute to the NRC search for potency biomarkers, based on the RS analysis of CLIC-01 patient cell samples taken prior to infusion. This contributes a novel and orthogonal analytical dimension to the overall NRC search for biomarkers that predict the efficacy of the treatment for each patient, and thereby when costly CAR-T cell treatments should be performed, description french : Analyse clinique par spectroscopie Raman des cellules CAR-T, expected results english : In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems., expected results french : À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides., additional information english : This agreement has been amended 1 time(s). The end date of this agreement has been modified by 243 days., additional information french : Cet accord a été modifié 1 fois.  La date de fin du présent accord a été changé de 243 jours., owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada