Reference number : 172-2021-2022-Q1-974328, amendment number : 2, agreement type : G, recipient legal name : Dalhousie University, recipient country : CA, recipient province : NS, recipient city : Halifax|Halifax, recipient postal code : B3H 4R2, program name english : Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives, program name french : Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D, program purpose english : Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas., program purpose french : Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires., agreement title english : High resolution immunometabolomics for the discovery and verification of biomarkers of CAR-T efficacy, agreement title french : Application de l’immunométabolomique haute résolution à la recherche et à la validation de biomarqueurs de l’efficacité des cellules CAR-T, agreement number : 974328, agreement value : 174680.0, agreement start date : 2021-07-01, agreement end date : 2025-06-30, description english : Chimeric antigen receptor T-cells (CAR-T) are used to treat a variety of cancer. However, unlike well-defined drugs such as chemicals and antibodies, CAR-T are complex, living therapies. Therefore, it is difficult to objectively assess the potency of CAR-T. The overall objective of this project is to determine immunometabolomic biomarkers that can be measured prior to infusion of CAR-T into patients in order to predict the treatment efficacy for each patient.
The metabolic profile of all cells is determined by both their genomic makeup as well as their interaction with the environment. Unlike genomic profiles, the metabolomic profile can react rapidly to changes in nutrients, additives and other products added during the production of CAR-T cells from a patient’s own T-cells. Immunometabolomics can be used to rapidly and quantitatively profile hundreds of metabolites. By deploying advanced immunometabolomic techniques to the analysis of CAR-T cells in the context of on-going pre-clinical and clinical trials, we aim to identify robust immunometabolomic biomarkers of CAR-T efficacy., description french : Application de l’immunométabolomique haute résolution à la recherche et à la validation de biomarqueurs de l’efficacité des cellules CAR-T, expected results english : In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems., expected results french : À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides., additional information english : This agreement has been amended 2 time(s). The end date of this agreement has been modified by 365 days., additional information french : Cet accord a été modifié 2 fois.  La date de fin du présent accord a été changé de 365 jours., owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada