Reference number : 172-2021-2022-Q3-981426, amendment number : 1, agreement type : G, recipient legal name : University of Ottawa, recipient country : CA, recipient province : ON, recipient city : Ottawa|Ottawa, recipient postal code : K1N 6N5, program name english : Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives, program name french : Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D, program purpose english : Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas., program purpose french : Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires., agreement title english : Quantum bio-sensing for next generation health diagnostics, agreement title french : Biodétection quantique pour la prochaine génération de diagnostics médicaux, agreement number : 981426, agreement value : 272030.0, agreement start date : 2021-10-28, agreement end date : 2025-09-30, description english : Technological advances in imaging instrumentation in the near-infrared (NIR) range (1,000-1,700 nm) have resulted in unparalleled improvements in fluorescence image resolution and depth of penetration in biological tissues, required for highly sensitive and selective biosensors and preclinical in vivo imaging. However, one major limitation for the clinical adoption of NIR imaging is the lack of biocompatible and powerful (high quantum yield, high brightness) NIR emitters. Lanthanide-doped nanoparticles (Ln-NPs) constitute an emerging class of nanomaterials with extraordinary potential to drive innovation in biomolecular imaging and quantum chemical sensing. However, the transformation of these Ln-NPs into multi-modal imaging probes, intelligent bio-sensors and theranostic agents requires innovative design engineering based on understanding of their structure-property relationships, biocompatibility, and nano-bio interactions. The Project will lead to the development of powerful bioprobes capable of non-invasive monitoring of biochemical changes and processes deep in the body and in clinical samples., description french : Biodétection quantique pour la prochaine génération de diagnostics médicaux, expected results english : In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems., expected results french : À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides., additional information english : This agreement has been amended 1 time(s). The end date of this agreement has been modified by 351 days., additional information french : Cet accord a été modifié 1 fois.  La date de fin du présent accord a été changé de 351 jours., owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada