Reference number : GC-2017-Q1-00480, amendment number : , agreement type : G, recipient legal name : Boffito, Daria Camilla (École Polytechnique de Montréal), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The company Dymedso (Boisbriand, QC) manufactures The Frequencer(TM), a digitally controlled acoustic_x000D_
airway clearance device that promotes bronchial drainage by inducing vibrations in the chest wall of a patient._x000D_
The Frequencer(TM) is recommended for patients affected by defective mucociliary clearance including cystic_x000D_
fibrosis (CF), chronic bronchitis, thoracic wall defects among other pathologies. With an operating frequency_x000D_
of 20 to 65 Hz, The Frequencer(TM) provides a gentler therapy than the traditional "clapping" method or_x000D_
postural drainage. Dymedso is looking to give an answer to its customers who claim a better mucous fluidity at_x000D_
frequencies of 37 to 42 Hz. The lack of mucous fluidity in patients with CF is ascribable to its dehydration as a_x000D_
consequence of insufficient excretion of NaCl to the airways, leading to the increase of secretion viscosity. In_x000D_
the project proposed we will realize a series of tests to elucidate possible mechanisms underlying the transport_x000D_
of water and salt (NaCl) in mucin solutions at different operating frequencies and powers of The_x000D_
Frequencer(TM). The objective will be achieved applying the head of The Frequencer(TM) to the top of a_x000D_
ad-hoc reactor containing biphasic mixtures of water and mucin solutions with salt. Besides water and salt_x000D_
concentration in the artificial mucous after exposure to different operating frequencies and powers of the_x000D_
Frequencer(TM), we will quantify changes in mucous rheological behavior and develop a numerical model for_x000D_
water and salt mass transfer through the mucin solutions., program purpose french : The company Dymedso (Boisbriand, QC) manufactures The Frequencer(TM), a digitally controlled acoustic_x000D_
airway clearance device that promotes bronchial drainage by inducing vibrations in the chest wall of a patient._x000D_
The Frequencer(TM) is recommended for patients affected by defective mucociliary clearance including cystic_x000D_
fibrosis (CF), chronic bronchitis, thoracic wall defects among other pathologies. With an operating frequency_x000D_
of 20 to 65 Hz, The Frequencer(TM) provides a gentler therapy than the traditional "clapping" method or_x000D_
postural drainage. Dymedso is looking to give an answer to its customers who claim a better mucous fluidity at_x000D_
frequencies of 37 to 42 Hz. The lack of mucous fluidity in patients with CF is ascribable to its dehydration as a_x000D_
consequence of insufficient excretion of NaCl to the airways, leading to the increase of secretion viscosity. In_x000D_
the project proposed we will realize a series of tests to elucidate possible mechanisms underlying the transport_x000D_
of water and salt (NaCl) in mucin solutions at different operating frequencies and powers of The_x000D_
Frequencer(TM). The objective will be achieved applying the head of The Frequencer(TM) to the top of a_x000D_
ad-hoc reactor containing biphasic mixtures of water and mucin solutions with salt. Besides water and salt_x000D_
concentration in the artificial mucous after exposure to different operating frequencies and powers of the_x000D_
Frequencer(TM), we will quantify changes in mucous rheological behavior and develop a numerical model for_x000D_
water and salt mass transfer through the mucin solutions., agreement title english : Influence of the operating frequency and amplitude in an acoustic airway clearance device, agreement title french : Influence of the operating frequency and amplitude in an acoustic airway clearance device, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-06-14, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada