Reference number : 172-2018-2019-Q3-913718, amendment number : 1, agreement type : C, recipient legal name : Entos Pharmaceuticals Inc., recipient country : CA, recipient province : AB, recipient city : Edmonton|Edmonton, recipient postal code : T5J 4P6, program name english : Industrial Research Assistance Program – Contributions to Firms, program name french : Programme d’aide à la recherche industrielle – Contributions aux entreprises, program purpose english : The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization, program purpose french : Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation, agreement title english : Towards Single-Step manufacturing of LNP Gene Therapy, agreement title french : Vers la fabrication en une étape de la thérapie génique LNP, agreement number : 913718, agreement value : 117600.0, agreement start date : 2018-10-01, agreement end date : 2019-09-30, description english : The goal of this project is to establish a method to synthesize Fusogenix DNA lipid nanoparticles using a single step manufacturing process. To achieve this, we will evaluate a number of methods to incorporate our fusogenic proteins into lipid nanoparticles using the Precision Nanosystems microfluidic platform. We expect that by pre-formulating one of the lipid components with fusogenic protein, we may be able to reduce the manufacturing to a single step compared to the current 2 step process. This will allow us to significantly improve our encapsulation efficiency and simplify our manufacturing process as we move to the clinic., description french : Vers la fabrication en une étape de la thérapie génique LNP, expected results english : The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization, expected results french : Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation, additional information english : This agreement has been amended 1 time(s). The total amended value is 117,600 dollars., additional information french : Cet accord a été modifié 1 fois La valeur totale des modifications est de   117 600 dollars., owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada