Reference number : GC-2017-Q1-00244, amendment number : , agreement type : G, recipient legal name : Cloutier, Guy (Université de Montréal), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Every day, patients admitted to critical care units are experiencing complications and often_x000D_
fatal deteriorating conditions. Severe complications leading to the syndrome of multiple organ_x000D_
dysfunctions or MODS result in a mortality rate at 41%. The MODS condition is characterized_x000D_
by a severe acute inflammatory reaction leading to vascular thrombosis, septic shock and_x000D_
impaired oxygenation of organs and tissues. Inflammatory blood markers can be prescribed_x000D_
for patient monitoring but results are obtained hours or days after sampling. In conditions_x000D_
where rapid medical decisions are required to improve the likelihood of patient survival, those_x000D_
blood tests are often of no value. We propose in this grant application a new bed side_x000D_
ultrasound technology to continuously monitor the state of inflammation for optimum patient_x000D_
treatment._x000D_
Red blood cell (RBC) aggregation is a strong marker of inflammation and has the unique_x000D_
advantage of offering continuous monitoring capability through ultrasound imaging. This grant_x000D_
proposes the development and integration of technologies to provide point-of-care patient_x000D_
monitoring based on the analysis of high-frequency ultrasound spectral data to measure the_x000D_
time-varying clustering of RBCs flowing within a superficial vein of the arm or ankle._x000D_
Preclinical results in a porcine model confirmed the capability of monitoring inflammationpromoted_x000D_
aggregation of RBCs with ultrasound. The proposed algorithm is patented and we_x000D_
propose the development of a portable instrument for use in restricted areas as surgery_x000D_
rooms and intensive care units. This instrument will consist in a bracelet attached innocuously_x000D_
to the patient and embedding high-frequency ultrasound transducers, an occluding device to_x000D_
control the blood flow, and a positioning device to collect ultrasound data processed by a_x000D_
miniaturized computer instrument to provide feedback to clinicians on the state of RBC_x000D_
aggregation., program purpose french : Every day, patients admitted to critical care units are experiencing complications and often_x000D_
fatal deteriorating conditions. Severe complications leading to the syndrome of multiple organ_x000D_
dysfunctions or MODS result in a mortality rate at 41%. The MODS condition is characterized_x000D_
by a severe acute inflammatory reaction leading to vascular thrombosis, septic shock and_x000D_
impaired oxygenation of organs and tissues. Inflammatory blood markers can be prescribed_x000D_
for patient monitoring but results are obtained hours or days after sampling. In conditions_x000D_
where rapid medical decisions are required to improve the likelihood of patient survival, those_x000D_
blood tests are often of no value. We propose in this grant application a new bed side_x000D_
ultrasound technology to continuously monitor the state of inflammation for optimum patient_x000D_
treatment._x000D_
Red blood cell (RBC) aggregation is a strong marker of inflammation and has the unique_x000D_
advantage of offering continuous monitoring capability through ultrasound imaging. This grant_x000D_
proposes the development and integration of technologies to provide point-of-care patient_x000D_
monitoring based on the analysis of high-frequency ultrasound spectral data to measure the_x000D_
time-varying clustering of RBCs flowing within a superficial vein of the arm or ankle._x000D_
Preclinical results in a porcine model confirmed the capability of monitoring inflammationpromoted_x000D_
aggregation of RBCs with ultrasound. The proposed algorithm is patented and we_x000D_
propose the development of a portable instrument for use in restricted areas as surgery_x000D_
rooms and intensive care units. This instrument will consist in a bracelet attached innocuously_x000D_
to the patient and embedding high-frequency ultrasound transducers, an occluding device to_x000D_
control the blood flow, and a positioning device to collect ultrasound data processed by a_x000D_
miniaturized computer instrument to provide feedback to clinicians on the state of RBC_x000D_
aggregation., agreement title english : Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring, agreement title french : Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring, agreement number : CHRPJ, agreement value : 301262.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada