Reference number : GC-2017-Q1-00252, amendment number : , agreement type : G, recipient legal name : Adamson, Robert (Dalhousie University), recipient country : CA, recipient province : nan, recipient city : Nova Scotia|Nouvelle-Écosse, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Optical coherence tomography (OCT) is an emerging modality for imaging the middle ear. It_x000D_
allows middle ear structures and their response to sound to be imaged through the intact_x000D_
eardrum. This technology represents an exciting new direction in the diagnosis of conductive_x000D_
hearing loss, an area which to date has largely had to be done "blind" due to the inadequacy_x000D_
of available imaging technologies. As the first research group to demonstrate clinical OCT_x000D_
imaging of the whole middle ear and middle ear vibrometry in vivo, we are well placed to_x000D_
advance this technology and have proposed a multi-faceted research plan to improve and_x000D_
clinically validate our prototype imaging system. We will be re-engineering our OCT system_x000D_
into an endoscopic form factor, adding new contrast mechanisms and working to improve_x000D_
image quality. These improvements will harness many new advances in OCT imaging_x000D_
technology including synthetic aperture focusing, compressed sensing, polarization-sensitive_x000D_
OCT and variance-based microangiography, none of which have been used before in the ear._x000D_
Our efforts to improve the engineering in our clinical system will be complemented by the_x000D_
construction of a preclinical OCT system specifically designed for measurements on human_x000D_
temporal bones, the most important model for pre-clinical validation of middle ear therapies._x000D_
On the clinical side we will be pursuing both quantitative and qualitative patient research at_x000D_
two sites to determine the technology's effectiveness in providing useful diagnostic_x000D_
information for patients suffering from conductive hearing loss. Our collaborators include_x000D_
world-leading experts in middle ear mechanics and disease from the US and Canada. Over_x000D_
the entire course of the project we will work closely with our Knowledge Translation partner,_x000D_
Conavi Medical, to move the device towards regulatory approval and onto the market, with_x000D_
the results of clinical research and engineering informing the ultimate device design and use., program purpose french : Optical coherence tomography (OCT) is an emerging modality for imaging the middle ear. It_x000D_
allows middle ear structures and their response to sound to be imaged through the intact_x000D_
eardrum. This technology represents an exciting new direction in the diagnosis of conductive_x000D_
hearing loss, an area which to date has largely had to be done "blind" due to the inadequacy_x000D_
of available imaging technologies. As the first research group to demonstrate clinical OCT_x000D_
imaging of the whole middle ear and middle ear vibrometry in vivo, we are well placed to_x000D_
advance this technology and have proposed a multi-faceted research plan to improve and_x000D_
clinically validate our prototype imaging system. We will be re-engineering our OCT system_x000D_
into an endoscopic form factor, adding new contrast mechanisms and working to improve_x000D_
image quality. These improvements will harness many new advances in OCT imaging_x000D_
technology including synthetic aperture focusing, compressed sensing, polarization-sensitive_x000D_
OCT and variance-based microangiography, none of which have been used before in the ear._x000D_
Our efforts to improve the engineering in our clinical system will be complemented by the_x000D_
construction of a preclinical OCT system specifically designed for measurements on human_x000D_
temporal bones, the most important model for pre-clinical validation of middle ear therapies._x000D_
On the clinical side we will be pursuing both quantitative and qualitative patient research at_x000D_
two sites to determine the technology's effectiveness in providing useful diagnostic_x000D_
information for patients suffering from conductive hearing loss. Our collaborators include_x000D_
world-leading experts in middle ear mechanics and disease from the US and Canada. Over_x000D_
the entire course of the project we will work closely with our Knowledge Translation partner,_x000D_
Conavi Medical, to move the device towards regulatory approval and onto the market, with_x000D_
the results of clinical research and engineering informing the ultimate device design and use., agreement title english : Optical coherence tomography of the middle ear, agreement title french : Optical coherence tomography of the middle ear, agreement number : CHRPJ, agreement value : 337717.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada