Reference number : GC-2017-Q1-00230, amendment number : , agreement type : G, recipient legal name : Poon, Joyce (University of Toronto), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : As the average age of the population of Canada and the developed world rises,_x000D_
neurodegenerative conditions will become increasingly prevalent and a growing burden on_x000D_
the healthcare system and economy. A major neurodegenerative disease is Alzheimers_x000D_
disease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1_x000D_
million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, there_x000D_
is no cure or effective treatment. The Lancet Neurology Commission recently stated, an_x000D_
effective therapy for AD is perhaps the greatest unmet need facing modern medicine."_x000D_
This project addresses the challenge of understanding neuron circuits in the brain involved in_x000D_
memory, with the goal of improving the efficacy of neurostimulation therapies for AD and_x000D_
dementia. Such treatments would stimulate specific brain circuits to promote memory_x000D_
encoding and/or retrieval in patients with AD or dementia. The project will create a new type_x000D_
of wireless, implantable deep brain probes for rodent experiments on memory loss rescue_x000D_
that uses optical stimulation and electrical stimulation+recording of specific groups of_x000D_
neurons. Importantly, these brain probes will be made using the same processes and_x000D_
infrastructure as semiconductor microelectronics to ensure compatibility with volume_x000D_
manufacturing and a viable technology translation path that will widely benefit neuroscientists_x000D_
and clinical researchers._x000D_
This project brings together world-class expertise from around the globe in photonics,_x000D_
electronics, neuroscience, and deep brain stimulation. In addition to the Canadian team_x000D_
members, the project involves collaborators in France and United States who will provide_x000D_
complementary expertise in the design, fabrication, and testing of the neural probes. The_x000D_
results of this international project will benefit the health of Canadians and lead to high-value_x000D_
neurotechnology products that are designed and integrated in Canada., program purpose french : As the average age of the population of Canada and the developed world rises,_x000D_
neurodegenerative conditions will become increasingly prevalent and a growing burden on_x000D_
the healthcare system and economy. A major neurodegenerative disease is Alzheimers_x000D_
disease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1_x000D_
million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, there_x000D_
is no cure or effective treatment. The Lancet Neurology Commission recently stated, an_x000D_
effective therapy for AD is perhaps the greatest unmet need facing modern medicine."_x000D_
This project addresses the challenge of understanding neuron circuits in the brain involved in_x000D_
memory, with the goal of improving the efficacy of neurostimulation therapies for AD and_x000D_
dementia. Such treatments would stimulate specific brain circuits to promote memory_x000D_
encoding and/or retrieval in patients with AD or dementia. The project will create a new type_x000D_
of wireless, implantable deep brain probes for rodent experiments on memory loss rescue_x000D_
that uses optical stimulation and electrical stimulation+recording of specific groups of_x000D_
neurons. Importantly, these brain probes will be made using the same processes and_x000D_
infrastructure as semiconductor microelectronics to ensure compatibility with volume_x000D_
manufacturing and a viable technology translation path that will widely benefit neuroscientists_x000D_
and clinical researchers._x000D_
This project brings together world-class expertise from around the globe in photonics,_x000D_
electronics, neuroscience, and deep brain stimulation. In addition to the Canadian team_x000D_
members, the project involves collaborators in France and United States who will provide_x000D_
complementary expertise in the design, fabrication, and testing of the neural probes. The_x000D_
results of this international project will benefit the health of Canadians and lead to high-value_x000D_
neurotechnology products that are designed and integrated in Canada., agreement title english : Wireless neurophotonic probes for the interrogation of neurons in memory circuits, agreement title french : Wireless neurophotonic probes for the interrogation of neurons in memory circuits, agreement number : CHRPJ, agreement value : 349500.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada