Reference number : GC-2017-Q4-01032, amendment number : , agreement type : G, recipient legal name : Legault, Claude (Université de Sherbrooke), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The health sector is facing numerous challenges. For example, the emergence of multidrug-resistant pathogens_x000D_
requires the development of new antibiotic drugs to protect the population. In this context, organic synthesis_x000D_
plays a vital role. Indeed, the development of new synthetic methods and reagents for the creation and_x000D_
evaluation of new molecules of biological interest is the foundation on which we improve the drugs available_x000D_
to treat illnesses. Consequently, there is a need to expand the pool of reagents available supporting drug_x000D_
development. One strategy is to use libraries of high-value building blocks reagents that enable rapid creation_x000D_
of complex and diverse molecules._x000D_
Intellisyn is thus looking to acquire a diversified collection of highly-functionalized organotrifluoroborate salts_x000D_
and boronic acids, which will greatly expand their reagents library. The goal of this project is to create such_x000D_
library, using reagents recently developed in our group. This will greatly expand the reagents library of_x000D_
Intellisyn. The compounds furnished through this project are not available commercially and will greatly_x000D_
facilitate their drug development pipeline. It will consequently contribute to their competitiveness and_x000D_
expansion in Canada. In addition, this project will enable the development of new arylation methods that will_x000D_
be useful in the field of organic synthesis., program purpose french : The health sector is facing numerous challenges. For example, the emergence of multidrug-resistant pathogens_x000D_
requires the development of new antibiotic drugs to protect the population. In this context, organic synthesis_x000D_
plays a vital role. Indeed, the development of new synthetic methods and reagents for the creation and_x000D_
evaluation of new molecules of biological interest is the foundation on which we improve the drugs available_x000D_
to treat illnesses. Consequently, there is a need to expand the pool of reagents available supporting drug_x000D_
development. One strategy is to use libraries of high-value building blocks reagents that enable rapid creation_x000D_
of complex and diverse molecules._x000D_
Intellisyn is thus looking to acquire a diversified collection of highly-functionalized organotrifluoroborate salts_x000D_
and boronic acids, which will greatly expand their reagents library. The goal of this project is to create such_x000D_
library, using reagents recently developed in our group. This will greatly expand the reagents library of_x000D_
Intellisyn. The compounds furnished through this project are not available commercially and will greatly_x000D_
facilitate their drug development pipeline. It will consequently contribute to their competitiveness and_x000D_
expansion in Canada. In addition, this project will enable the development of new arylation methods that will_x000D_
be useful in the field of organic synthesis., agreement title english : Synthesis of a diversified boron reagent library for drug development, agreement title french : Synthesis of a diversified boron reagent library for drug development, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-02-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada