Reference number : GC-2017-Q4-00019, amendment number : , agreement type : G, recipient legal name : Adronov, Alex (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : This proposal aims to develop water-soluble polymer formulations that can be cast into thin polymer strips and_x000D_
can contain pharmaceutical and nutraceutical agents in oil-form. This material will be developed into an oral_x000D_
drug-delivery agent that can rapidly release the desired active ingredients within the oral cavity (sub-lingual or_x000D_
buccal). Such oral delivery is advantageous as it circumvents the digestive tract, allowing active ingredients to_x000D_
enter directly into the bloodstream through the oral mucosa. It is also an ideal delivery vehicle for patients that_x000D_
are incapable of swallowing pills, such as children, the elderly, and those suffering from nausea (such as_x000D_
oncology patients). A number of drug formulations are available in oil form, but dosing and administration of_x000D_
such drugs as liquids poses challenges, in that a medical professional must measure the appropriate dose and_x000D_
ensure that it is consistently given to the patient. Incorporation of precise quantities of therapeutic agents_x000D_
within rapidly dissolving polymer strips allows easy self-administration by the patient, and provides a highly_x000D_
effective and reliable means of drug delivery. However, dispersion of oil-based agents within a water-soluble_x000D_
polymer matrix is challenging, and requires development of appropriate formulations to ensure that oils are_x000D_
uniformly dispersed and maintain stable droplet morphology during storage. The development of such_x000D_
formulations is the goal of this project., program purpose french : This proposal aims to develop water-soluble polymer formulations that can be cast into thin polymer strips and_x000D_
can contain pharmaceutical and nutraceutical agents in oil-form. This material will be developed into an oral_x000D_
drug-delivery agent that can rapidly release the desired active ingredients within the oral cavity (sub-lingual or_x000D_
buccal). Such oral delivery is advantageous as it circumvents the digestive tract, allowing active ingredients to_x000D_
enter directly into the bloodstream through the oral mucosa. It is also an ideal delivery vehicle for patients that_x000D_
are incapable of swallowing pills, such as children, the elderly, and those suffering from nausea (such as_x000D_
oncology patients). A number of drug formulations are available in oil form, but dosing and administration of_x000D_
such drugs as liquids poses challenges, in that a medical professional must measure the appropriate dose and_x000D_
ensure that it is consistently given to the patient. Incorporation of precise quantities of therapeutic agents_x000D_
within rapidly dissolving polymer strips allows easy self-administration by the patient, and provides a highly_x000D_
effective and reliable means of drug delivery. However, dispersion of oil-based agents within a water-soluble_x000D_
polymer matrix is challenging, and requires development of appropriate formulations to ensure that oils are_x000D_
uniformly dispersed and maintain stable droplet morphology during storage. The development of such_x000D_
formulations is the goal of this project., agreement title english : Thin-film Delivery of Oil-Based Therapeutics, agreement title french : Thin-film Delivery of Oil-Based Therapeutics, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada