Reference number : GC-2017-Q1-00229, amendment number : , agreement type : G, recipient legal name : Tang, Shuo (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : According to the Canadian Cancer Society, the 5-year survival rate for oral cancer is only_x000D_
63%. Each year 4,600 new cases in Canada and 300,000 cases worldwide are identified and_x000D_
on average, half of the patients die within 5 years of diagnosis. The recurrence rate of oral_x000D_
cancer after surgery is high at 20%. Therefore, there is a critical need for new technology that_x000D_
can improve the early detection and treatment of oral cancer. In this project, a new point-ofcare_x000D_
cancer imaging device based on multiphoton imaging will be developed to provide highresolution_x000D_
imaging of oral mucosa lesions in vivo and in real-time. Multiphoton imaging can_x000D_
provide visualization of important biomarkers for cancer detection: the morphological changes_x000D_
of tumor cells and nuclei, and the density and ordering of the underlying collagen fibers which_x000D_
facilitates the progression and invasion of tumor cells. It has been demonstrated to be very_x000D_
successful in pre-clinical cancer studies on animal models. Translating multiphoton imaging_x000D_
into clinical applications is just beginning. Challenges include handling femtosecond pluses_x000D_
and limited signal to noise ratio. We will address those challenges and design a portable_x000D_
multiphoton system with a handheld probe for performing in vivo imaging of the oral mucosa._x000D_
In vivo imaging on patients will be carried out to evaluate the device for guided biopsy and_x000D_
tumor margin detection. The new technology can improve cancer management by real-time_x000D_
assessment of tumor noninvasively and guiding decisions on when and where to take_x000D_
biopsies for early cancer detection., program purpose french : According to the Canadian Cancer Society, the 5-year survival rate for oral cancer is only_x000D_
63%. Each year 4,600 new cases in Canada and 300,000 cases worldwide are identified and_x000D_
on average, half of the patients die within 5 years of diagnosis. The recurrence rate of oral_x000D_
cancer after surgery is high at 20%. Therefore, there is a critical need for new technology that_x000D_
can improve the early detection and treatment of oral cancer. In this project, a new point-ofcare_x000D_
cancer imaging device based on multiphoton imaging will be developed to provide highresolution_x000D_
imaging of oral mucosa lesions in vivo and in real-time. Multiphoton imaging can_x000D_
provide visualization of important biomarkers for cancer detection: the morphological changes_x000D_
of tumor cells and nuclei, and the density and ordering of the underlying collagen fibers which_x000D_
facilitates the progression and invasion of tumor cells. It has been demonstrated to be very_x000D_
successful in pre-clinical cancer studies on animal models. Translating multiphoton imaging_x000D_
into clinical applications is just beginning. Challenges include handling femtosecond pluses_x000D_
and limited signal to noise ratio. We will address those challenges and design a portable_x000D_
multiphoton system with a handheld probe for performing in vivo imaging of the oral mucosa._x000D_
In vivo imaging on patients will be carried out to evaluate the device for guided biopsy and_x000D_
tumor margin detection. The new technology can improve cancer management by real-time_x000D_
assessment of tumor noninvasively and guiding decisions on when and where to take_x000D_
biopsies for early cancer detection., agreement title english : Handheld Multiphoton Imaging Device for Detecting Oral Cancer, agreement title french : Handheld Multiphoton Imaging Device for Detecting Oral Cancer, agreement number : CHRPJ, agreement value : 294250.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada