Reference number : GC-2017-Q1-00372, amendment number : , agreement type : G, recipient legal name : Zhang, Xu (Shine) (Cape Breton University), recipient country : CA, recipient province : nan, recipient city : Nova Scotia|Nouvelle-Écosse, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Chelation Partners (CP) Co. develops highly efficient iron-binding polymer molecules that remove biologically_x000D_
available iron, making pathogens thousands of times more susceptible to antibiotics. For example, CP_x000D_
developed the chelator DIBI, which is effective in inhibiting the growth of Gram-positive bacteria,_x000D_
Gram-negative bacteria, and fungi in laboratory culture. However, many bacteria are well known to form_x000D_
biofilms, which contains group of bacteria cells sticking to each other and embedded within a self-produced_x000D_
extracellular polymeric substance-based matrix. The bacterial cells growing in a biofilm are different from_x000D_
planktonic cells of the same organism, which are free-moving single cells in a liquid medium. The striking_x000D_
difference of the bacteria in a biofilm is their much higher resistance to antibiotics than the planktonic ones._x000D_
Therefore, it would be desirable to develop technology that can sensitize the biofilm to antibiotics. Since iron is_x000D_
critical for biofilm growth, CP hypothesizes that the chelators DIBI may be effective to sensitize biofilm_x000D_
towards antibiotic treatment. This project is proposed to test the idea with experimental evidence. The_x000D_
knowledge obtained in the project is important for CP to explore the full value of its product and make decision_x000D_
on how to incorporate the results into its product streams., program purpose french : Chelation Partners (CP) Co. develops highly efficient iron-binding polymer molecules that remove biologically_x000D_
available iron, making pathogens thousands of times more susceptible to antibiotics. For example, CP_x000D_
developed the chelator DIBI, which is effective in inhibiting the growth of Gram-positive bacteria,_x000D_
Gram-negative bacteria, and fungi in laboratory culture. However, many bacteria are well known to form_x000D_
biofilms, which contains group of bacteria cells sticking to each other and embedded within a self-produced_x000D_
extracellular polymeric substance-based matrix. The bacterial cells growing in a biofilm are different from_x000D_
planktonic cells of the same organism, which are free-moving single cells in a liquid medium. The striking_x000D_
difference of the bacteria in a biofilm is their much higher resistance to antibiotics than the planktonic ones._x000D_
Therefore, it would be desirable to develop technology that can sensitize the biofilm to antibiotics. Since iron is_x000D_
critical for biofilm growth, CP hypothesizes that the chelators DIBI may be effective to sensitize biofilm_x000D_
towards antibiotic treatment. This project is proposed to test the idea with experimental evidence. The_x000D_
knowledge obtained in the project is important for CP to explore the full value of its product and make decision_x000D_
on how to incorporate the results into its product streams., agreement title english : The efficacy of CP's chelator polymers for anti-biofilm treatment, agreement title french : The efficacy of CP's chelator polymers for anti-biofilm treatment, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-06-14, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada