Reference number : GC-2017-Q4-01612, amendment number : , agreement type : G, recipient legal name : Schafer, Laurel (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : BC's forest products are rich in naturally occuring terpenes, a class of molecules that display anti-fungal,_x000D_
anti-bacterial and medicinal bioactivity. These molecules can be further chemically modifed to access_x000D_
compounds of commercial value as flavours and fragrances as well as medicines, herbicides and pesticides._x000D_
All of these products are bioproducts and they enhance the commercial opportunity of BC's Forestry Industry._x000D_
Notably chemical modification of terpenes has not included strategies for incorporating nitrogen into these_x000D_
complex molecular structures. However, nitrogen containing terpenes are a class of naturally occuring_x000D_
products called terpenoid-alkaloids and such natural products are known to display potent biological activity._x000D_
For example, terpenoid-alkaloids have been used in cancer therapies and in treatments for heart disease._x000D_
Recent advances in the Schafer laboratory at UBC have resulted in the development of new catalytic_x000D_
technologies that can install nitrogen into terpenes in one efficient chemical transformation. There are no_x000D_
waste by-products formed and the transformation is energy efficient, making this chemical reaction ideally_x000D_
suited for application in commercial processes. This proposal will prepare 20 different synthetic_x000D_
terpenoid-alkaloids for investigation as potential drugs. This work will be completed in collaboration with_x000D_
Nanaimo Forest Products to determine preferred terpenes for modification and with the Centre for Drug_x000D_
Research and Development in Vancouver for screening of new terpenoid-alkaloids for biological activity., program purpose french : BC's forest products are rich in naturally occuring terpenes, a class of molecules that display anti-fungal,_x000D_
anti-bacterial and medicinal bioactivity. These molecules can be further chemically modifed to access_x000D_
compounds of commercial value as flavours and fragrances as well as medicines, herbicides and pesticides._x000D_
All of these products are bioproducts and they enhance the commercial opportunity of BC's Forestry Industry._x000D_
Notably chemical modification of terpenes has not included strategies for incorporating nitrogen into these_x000D_
complex molecular structures. However, nitrogen containing terpenes are a class of naturally occuring_x000D_
products called terpenoid-alkaloids and such natural products are known to display potent biological activity._x000D_
For example, terpenoid-alkaloids have been used in cancer therapies and in treatments for heart disease._x000D_
Recent advances in the Schafer laboratory at UBC have resulted in the development of new catalytic_x000D_
technologies that can install nitrogen into terpenes in one efficient chemical transformation. There are no_x000D_
waste by-products formed and the transformation is energy efficient, making this chemical reaction ideally_x000D_
suited for application in commercial processes. This proposal will prepare 20 different synthetic_x000D_
terpenoid-alkaloids for investigation as potential drugs. This work will be completed in collaboration with_x000D_
Nanaimo Forest Products to determine preferred terpenes for modification and with the Centre for Drug_x000D_
Research and Development in Vancouver for screening of new terpenoid-alkaloids for biological activity., agreement title english : From trees to treatments. Catalytic amination of terpenes and biological screening, agreement title french : From trees to treatments. Catalytic amination of terpenes and biological screening, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada