Reference number : GC-2017-Q2-00483, amendment number : , agreement type : G, recipient legal name : Santerre, Paul (University of Toronto), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Idea to Innovation, program name french : De l'idée à l'innovation, program purpose english : The discovery/invention that is the subject of this NSERC I2I Market assessment proposal is a novel synthetic_x000D_
polymer referred to as pro-healing polymer (PHP) (Univ.Toronto Disclosure No. 10002755, US provisional_x000D_
application No._x000D_
62/037,359, PCT No. PCT/CA2015/000461). PHP has the ability to reduce implant device-associated_x000D_
inflammation by influencing initial adsorbed protein immediately following implantation. A major_x000D_
complication associated with implanted devices is the formation of a fibrotic capsule as a result of a chronic_x000D_
inflammatory response that in many instances can impede the device's performance. This chronic inflammatory_x000D_
response is mediated by white blood cells, particularly monocytes and derived macrophages. Following the_x000D_
surgical implantation of a biomaterial, whether it is part of a biomedical device or tissue engineered product,_x000D_
the first biological event that occurs is the adsorption of proteins from protein-rich bodily fluids (e.g. blood,_x000D_
interstitial fluid). Blood monocytes and macrophages that adhere to the implants thus interact with the_x000D_
biomaterial-associated adsorbed protein layer, rather than directly with the device itself. PHP is prepared using_x000D_
three monomers which can be selected to (1) provide desirable mechanical properties depending on the_x000D_
requirements of a proposed application, (2) exhibit biodegradable/bioresorbable or substantially_x000D_
non-degradable properties, and (3) be manufactured through both heat and light curing methods. A common_x000D_
feature of PHP is the ability to modulate the pro-inflammatory serum protein immunoglobulin G (IgG) to limit_x000D_
exposure of pro-inflammatory domains, thus reducing activation of adherent monocytes and macrophages that_x000D_
can damage the implant. The main aim of the proposed market assessment is to assess the market potential of_x000D_
the proposed product through assessment of market size, competitive landscape, barriers to entry, and market_x000D_
trends. Analysis will also be performed to assess potential factors affecting the commercialization of the_x000D_
technology, including issues regarding product adoption by end-users, product positioning, potential, program purpose french : The discovery/invention that is the subject of this NSERC I2I Market assessment proposal is a novel synthetic_x000D_
polymer referred to as pro-healing polymer (PHP) (Univ.Toronto Disclosure No. 10002755, US provisional_x000D_
application No._x000D_
62/037,359, PCT No. PCT/CA2015/000461). PHP has the ability to reduce implant device-associated_x000D_
inflammation by influencing initial adsorbed protein immediately following implantation. A major_x000D_
complication associated with implanted devices is the formation of a fibrotic capsule as a result of a chronic_x000D_
inflammatory response that in many instances can impede the device's performance. This chronic inflammatory_x000D_
response is mediated by white blood cells, particularly monocytes and derived macrophages. Following the_x000D_
surgical implantation of a biomaterial, whether it is part of a biomedical device or tissue engineered product,_x000D_
the first biological event that occurs is the adsorption of proteins from protein-rich bodily fluids (e.g. blood,_x000D_
interstitial fluid). Blood monocytes and macrophages that adhere to the implants thus interact with the_x000D_
biomaterial-associated adsorbed protein layer, rather than directly with the device itself. PHP is prepared using_x000D_
three monomers which can be selected to (1) provide desirable mechanical properties depending on the_x000D_
requirements of a proposed application, (2) exhibit biodegradable/bioresorbable or substantially_x000D_
non-degradable properties, and (3) be manufactured through both heat and light curing methods. A common_x000D_
feature of PHP is the ability to modulate the pro-inflammatory serum protein immunoglobulin G (IgG) to limit_x000D_
exposure of pro-inflammatory domains, thus reducing activation of adherent monocytes and macrophages that_x000D_
can damage the implant. The main aim of the proposed market assessment is to assess the market potential of_x000D_
the proposed product through assessment of market size, competitive landscape, barriers to entry, and market_x000D_
trends. Analysis will also be performed to assess potential factors affecting the commercialization of the_x000D_
technology, including issues regarding product adoption by end-users, product positioning, potential, agreement title english : An assessment of market opportunities for pro-healing polymer (PHP) technology, agreement title french : An assessment of market opportunities for pro-healing polymer (PHP) technology, agreement number : I2IPJ, agreement value : 14775.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada