Reference number : GC-2017-Q1-03360, amendment number : , agreement type : G, recipient legal name : Crosby, William (University of Windsor), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Summary of the Proposal 
Proteins are complex molecules that carry out a variety of important cellular functions that range from structure determination to the regulation of the cell&rsquo;s chemistry. It follows that the number of different types and amounts of proteins present in a cell at any given time are critical to defining the function of that cell - including their contribution to the tissues and organs that make up the 'body plan' of the organism of which they are a part. Proteins are coded or &lsquo;expressed&rsquo; by genes as the &lsquo;dictionary&rsquo; of life, and it is at the point of gene expression and protein synthesis that the cell can regulate expression of the many thousands of proteins that exist at any given time. But this complex repertoire of cellular proteins can also be regulated after they are synthesized - by a process of selected protein destruction as one aspect of the ability of cells to regulate their complement of proteins. Nowhere is this more evident than in plants, where the targeted protein degradation machinery is about 10x more complex than in humans. In this proposal, we seek to better understand the underlying mechanisms by which targeted protein destruction is regulated in plants. This foundational knowledge will have far-reaching impacts on our understanding of how plants develop and how they adapt to environmental challenges such as drought stress, cold adaptation and global warming., program purpose french : Summary of the Proposal 
Proteins are complex molecules that carry out a variety of important cellular functions that range from structure determination to the regulation of the cell&rsquo;s chemistry. It follows that the number of different types and amounts of proteins present in a cell at any given time are critical to defining the function of that cell - including their contribution to the tissues and organs that make up the 'body plan' of the organism of which they are a part. Proteins are coded or &lsquo;expressed&rsquo; by genes as the &lsquo;dictionary&rsquo; of life, and it is at the point of gene expression and protein synthesis that the cell can regulate expression of the many thousands of proteins that exist at any given time. But this complex repertoire of cellular proteins can also be regulated after they are synthesized - by a process of selected protein destruction as one aspect of the ability of cells to regulate their complement of proteins. Nowhere is this more evident than in plants, where the targeted protein degradation machinery is about 10x more complex than in humans. In this proposal, we seek to better understand the underlying mechanisms by which targeted protein destruction is regulated in plants. This foundational knowledge will have far-reaching impacts on our understanding of how plants develop and how they adapt to environmental challenges such as drought stress, cold adaptation and global warming., agreement title english : Molecular Regulation of Auxin Signaling in Plant Development, agreement title french : Molecular Regulation of Auxin Signaling in Plant Development, agreement number : RGPIN, agreement value : 125000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada