Reference number : GC-2017-Q2-04272, amendment number : , agreement type : G, recipient legal name : Tranmer, Geoffrey (University of Manitoba)|Tranmer, Geoffrey (Université du Manitoba), recipient country : CA, recipient province : nan, recipient city : Manitoba, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Analogues of natural products are known to be an abundant reservoir for medicinally relevant compounds, with_x000D_
many such molecules being commercialized into therapeutically useful drugs, such as cancer therapies._x000D_
Historically, considerable effort in the field of organic chemistry has been applied to the development of new_x000D_
synthetic methods for the construction of these natural products and their respective therapeutically useful_x000D_
derivatives. Although many synthetic transformations have been developed, new synthetic methods are_x000D_
urgently required to make syntheses shorter, safer, greener and more atom economical. It is the goal of this_x000D_
research project to resolve problematic process chemistry reactions that have been identified by Dalton Pharma_x000D_
Services by creating new flow chemistry-based methods that will be used in the synthesis of active_x000D_
pharmaceutical ingredients (API), which are commonly derivatives of natural products. Specifically, we will_x000D_
develop new flow-based synthesis protocols for i) reductions using lithium aluminum hydride (LiAlH4) and ii)_x000D_
reduction of alkynes to alkenes that are suitable for process scale applications. Currently, these types of_x000D_
reactions are particularly problematic to perform on large scale due to safety and reactivity problems that are_x000D_
inherent to batch chemistry reactions. To solve these issues, we will develop flow chemistry synthetic protocols_x000D_
that will replace these current process scale batch methods (vide infra). The field of flow chemistry is poised to_x000D_
have a transformative effect on the discipline of organic synthesis by avoiding the costly, inefficient methods of_x000D_
batch, and replacing them with superior methods that allow for safer, greener and more proficient chemical_x000D_
transformations. In its simplest form, flow chemistry replaces conventional fixed-volume batch reaction flasks_x000D_
with flow microreactors, hence the term "flow" chemistry. This research project plans to utilize the benefits of_x000D_
flow chemistry and develop continuous flow processes that will solve the problems that are inherent when_x000D_
scaling-up these batch reactions. Overall, resolving the problematic batch reactions that have been identified by_x000D_
Dalton Pharma Services, and yield much more cost-effective and safer chemical processes., program purpose french : Analogues of natural products are known to be an abundant reservoir for medicinally relevant compounds, with_x000D_
many such molecules being commercialized into therapeutically useful drugs, such as cancer therapies._x000D_
Historically, considerable effort in the field of organic chemistry has been applied to the development of new_x000D_
synthetic methods for the construction of these natural products and their respective therapeutically useful_x000D_
derivatives. Although many synthetic transformations have been developed, new synthetic methods are_x000D_
urgently required to make syntheses shorter, safer, greener and more atom economical. It is the goal of this_x000D_
research project to resolve problematic process chemistry reactions that have been identified by Dalton Pharma_x000D_
Services by creating new flow chemistry-based methods that will be used in the synthesis of active_x000D_
pharmaceutical ingredients (API), which are commonly derivatives of natural products. Specifically, we will_x000D_
develop new flow-based synthesis protocols for i) reductions using lithium aluminum hydride (LiAlH4) and ii)_x000D_
reduction of alkynes to alkenes that are suitable for process scale applications. Currently, these types of_x000D_
reactions are particularly problematic to perform on large scale due to safety and reactivity problems that are_x000D_
inherent to batch chemistry reactions. To solve these issues, we will develop flow chemistry synthetic protocols_x000D_
that will replace these current process scale batch methods (vide infra). The field of flow chemistry is poised to_x000D_
have a transformative effect on the discipline of organic synthesis by avoiding the costly, inefficient methods of_x000D_
batch, and replacing them with superior methods that allow for safer, greener and more proficient chemical_x000D_
transformations. In its simplest form, flow chemistry replaces conventional fixed-volume batch reaction flasks_x000D_
with flow microreactors, hence the term "flow" chemistry. This research project plans to utilize the benefits of_x000D_
flow chemistry and develop continuous flow processes that will solve the problems that are inherent when_x000D_
scaling-up these batch reactions. Overall, resolving the problematic batch reactions that have been identified by_x000D_
Dalton Pharma Services, and yield much more cost-effective and safer chemical processes., agreement title english : Development of Flow Chemistry Techniques: Resolution of Problematic Industrial Process Chemistry Reactions, agreement title french : Development of Flow Chemistry Techniques: Resolution of Problematic Industrial Process Chemistry Reactions, agreement number : EGP, agreement value : 24992.0, agreement start date : 2017-09-20, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada