Reference number : GC-2017-Q3-00569, amendment number : , agreement type : G, recipient legal name : Narain, Ravin (University of Alberta), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Several strategies are currently being developed to improve the therapeutic efficacy of current drug molecules_x000D_
or new drugs are being developed with better performance due to many factors such as drug resistance,_x000D_
cytotoxicity of the drug molecules in therapeutic doses, degradation before reaching the target, difficulty in_x000D_
storage for long term and solubility issues. Therefore, there is a need to develop nano-drug delivery systems to_x000D_
address to the above issues. In our laboratory we have develop safe and effective polymer and nanogels systems_x000D_
for the delivery of both small drug molecules and macromolecules (such as protein, siRNA and DNA). These_x000D_
polymer based nano-systems have been engineered for excellent protection of the drug molecules, high_x000D_
encapsulation and with targeting abilities. In collaboration with TC Scientific Inc., the goal of this project is to_x000D_
develop an effective nano-drug delivery system for the therapeutic delivery of both hydrophilic and_x000D_
hydrophobic drug molecules. The temperature responsive nature of this nano-system will allow the facile_x000D_
encapsulation and controlled release of the drug in active form., program purpose french : Several strategies are currently being developed to improve the therapeutic efficacy of current drug molecules_x000D_
or new drugs are being developed with better performance due to many factors such as drug resistance,_x000D_
cytotoxicity of the drug molecules in therapeutic doses, degradation before reaching the target, difficulty in_x000D_
storage for long term and solubility issues. Therefore, there is a need to develop nano-drug delivery systems to_x000D_
address to the above issues. In our laboratory we have develop safe and effective polymer and nanogels systems_x000D_
for the delivery of both small drug molecules and macromolecules (such as protein, siRNA and DNA). These_x000D_
polymer based nano-systems have been engineered for excellent protection of the drug molecules, high_x000D_
encapsulation and with targeting abilities. In collaboration with TC Scientific Inc., the goal of this project is to_x000D_
develop an effective nano-drug delivery system for the therapeutic delivery of both hydrophilic and_x000D_
hydrophobic drug molecules. The temperature responsive nature of this nano-system will allow the facile_x000D_
encapsulation and controlled release of the drug in active form., agreement title english : Development of a versatile nano-drug delivery system, agreement title french : Development of a versatile nano-drug delivery system, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada