Reference number : GC-2017-Q1-00556, amendment number : , agreement type : G, recipient legal name : Brosseau, Christa (Saint Mary’s University), recipient country : CA, recipient province : nan, recipient city : Nova Scotia|Nouvelle-Écosse, recipient postal code : nan, program name english : Engage Plus Grants for Universities, program name french : Subvention d'engagement partenarial Plus pour les universités, program purpose english : Rapid diagnosis of human disease at the patient point-of-care is key to timely and effective treatment. This_x000D_
research project will explore the extent to which an advanced spectroscopic technique, known as_x000D_
surface-enhanced Raman spectroscopy (SERS) can be used to render a simple rapid vertical flow assay into a_x000D_
much more powerful quantitative test. A quantitative rapid vertical flow assay, which this project seeks to_x000D_
demonstrate, would allow for earlier detection of human disease, and would allow for improved health care_x000D_
monitoring (such as in determination of HIV viral load, etc). All of this would still be possible at the patient_x000D_
point-of-care, which would ensure rapid and effective disease treatment. Our recent Engage project is coming_x000D_
to an end, and we have made excellent progress on this front. Improved limit-of-detection and increased_x000D_
selectivity have been illustrated, as well as guidelines for the production of stable and reproducible gold_x000D_
colloids conjugated with both the capture agent and the Raman-active label. However, there is still much work_x000D_
to do, including pushing the limit of detection further through the exploration of other shapes / sizes of_x000D_
particles, as well as testing in biologically relevant matrices (i.e. serum). In addition, a robust data analytics_x000D_
approach is needed to advance the technology forward., program purpose french : Rapid diagnosis of human disease at the patient point-of-care is key to timely and effective treatment. This_x000D_
research project will explore the extent to which an advanced spectroscopic technique, known as_x000D_
surface-enhanced Raman spectroscopy (SERS) can be used to render a simple rapid vertical flow assay into a_x000D_
much more powerful quantitative test. A quantitative rapid vertical flow assay, which this project seeks to_x000D_
demonstrate, would allow for earlier detection of human disease, and would allow for improved health care_x000D_
monitoring (such as in determination of HIV viral load, etc). All of this would still be possible at the patient_x000D_
point-of-care, which would ensure rapid and effective disease treatment. Our recent Engage project is coming_x000D_
to an end, and we have made excellent progress on this front. Improved limit-of-detection and increased_x000D_
selectivity have been illustrated, as well as guidelines for the production of stable and reproducible gold_x000D_
colloids conjugated with both the capture agent and the Raman-active label. However, there is still much work_x000D_
to do, including pushing the limit of detection further through the exploration of other shapes / sizes of_x000D_
particles, as well as testing in biologically relevant matrices (i.e. serum). In addition, a robust data analytics_x000D_
approach is needed to advance the technology forward., agreement title english : Continued Evaluation of a Rapid Vertical Flow Assay Platform with Surface-Enhanced Raman Spectroscopy, agreement title french : Continued Evaluation of a Rapid Vertical Flow Assay Platform with Surface-Enhanced Raman Spectroscopy, agreement number : EGP2, agreement value : 12425.0, agreement start date : 2017-06-14, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada