Reference number : GC-2017-Q2-00365, amendment number : , agreement type : G, recipient legal name : Kubow, Stan (McGill University)|Kubow, Stan (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®_x000D_
Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following_x000D_
digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the health_x000D_
promoting properties of the supplement. There is presently no information, however, regarding the peptide and_x000D_
amino acid profiles generated from the digestion of the bovine-sourced Genacol collagen hydrolysate as the_x000D_
nature and profiles of these compounds will differ greatly depending upon of the type of processing used to_x000D_
produce the collagen hydrolysate and the food source of the collagen. In the present study, the profiles of the_x000D_
peptides and amino acids generated from digestive enzyme-mediated hydrolysis of the Genacol collagen_x000D_
product will be investigated using the dynamic simulated gut digestion model. This approach is the first step to_x000D_
ascertain the bioactive components contributing towards the health promoting properties of the Genacol_x000D_
collagen supplement and will aid in the development of more concentrated and potent hydrolyzed collagen_x000D_
products., program purpose french : Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®_x000D_
Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following_x000D_
digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the health_x000D_
promoting properties of the supplement. There is presently no information, however, regarding the peptide and_x000D_
amino acid profiles generated from the digestion of the bovine-sourced Genacol collagen hydrolysate as the_x000D_
nature and profiles of these compounds will differ greatly depending upon of the type of processing used to_x000D_
produce the collagen hydrolysate and the food source of the collagen. In the present study, the profiles of the_x000D_
peptides and amino acids generated from digestive enzyme-mediated hydrolysis of the Genacol collagen_x000D_
product will be investigated using the dynamic simulated gut digestion model. This approach is the first step to_x000D_
ascertain the bioactive components contributing towards the health promoting properties of the Genacol_x000D_
collagen supplement and will aid in the development of more concentrated and potent hydrolyzed collagen_x000D_
products., agreement title english : Assessment of peptide and amino acid profiles following simulated dynamic gastrointestinal model digestion of collagen hydrolysate, agreement title french : Assessment of peptide and amino acid profiles following simulated dynamic gastrointestinal model digestion of collagen hydrolysate, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada