Reference number : GC-2017-Q1-00246, amendment number : , agreement type : G, recipient legal name : Sinton, David (University of Toronto), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : In North America, one in six couples experiences infertility - a 2-fold increase since 1992._x000D_
Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and_x000D_
intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm_x000D_
 in the case of ICSI  a single sperm. This manual process is expensive, inefficient, prone to_x000D_
operator-error and largely random, resulting in sub-optimal pregnancy outcomes and_x000D_
ultimately the health of offspring. No sperm selection method addresses this growing market_x000D_
and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to_x000D_
navigate confined viscous regions of the female reproductive tract. We have formed a team of_x000D_
male fertility, microfluidic engineering, and clinical experts to develop and clinically test a_x000D_
microfluidic platform that leverages this natural swimming ability to select the highest quality_x000D_
sperm cells for direct injection - the Sperm Olympics., program purpose french : In North America, one in six couples experiences infertility - a 2-fold increase since 1992._x000D_
Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and_x000D_
intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm_x000D_
 in the case of ICSI  a single sperm. This manual process is expensive, inefficient, prone to_x000D_
operator-error and largely random, resulting in sub-optimal pregnancy outcomes and_x000D_
ultimately the health of offspring. No sperm selection method addresses this growing market_x000D_
and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to_x000D_
navigate confined viscous regions of the female reproductive tract. We have formed a team of_x000D_
male fertility, microfluidic engineering, and clinical experts to develop and clinically test a_x000D_
microfluidic platform that leverages this natural swimming ability to select the highest quality_x000D_
sperm cells for direct injection - the Sperm Olympics., agreement title english : Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection, agreement title french : Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection, agreement number : CHRPJ, agreement value : 272390.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada