Reference number : GC-2017-Q1-00238, amendment number : , agreement type : G, recipient legal name : Li, Yingfu (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Colorectal cancer (CRC) affects over a million people globally, resulting in ~600,000 deaths_x000D_
annually. Early detection of CRC can significantly reduce the mortality of CRC. When_x000D_
neoplastic lesions are found while they are locally contained, the 5-year survival rate is_x000D_
greater than 90%; when they spread to nearby lymph nodes or distant organs, the rate drops_x000D_
to 69% and 12%, respectively. The gold standard for CRC screening is colonoscopy; while_x000D_
this procedure is effective, it is expensive and invasive, and can cause complications. Less_x000D_
invasive or non-invasive methods are either prone to false-positives that require_x000D_
follow-up with colonoscopy or very expensive to be used as a screening tool. In this_x000D_
collaborative project, a team of academic researchers and clinicians will work together to_x000D_
develop a simple, litmus paper-like paper device for non-invasive detection of CRC. The test_x000D_
will be suited for routine CRC screening using stool samples. If successful, such a test will_x000D_
help save lives in Canada and around the world., program purpose french : Colorectal cancer (CRC) affects over a million people globally, resulting in ~600,000 deaths_x000D_
annually. Early detection of CRC can significantly reduce the mortality of CRC. When_x000D_
neoplastic lesions are found while they are locally contained, the 5-year survival rate is_x000D_
greater than 90%; when they spread to nearby lymph nodes or distant organs, the rate drops_x000D_
to 69% and 12%, respectively. The gold standard for CRC screening is colonoscopy; while_x000D_
this procedure is effective, it is expensive and invasive, and can cause complications. Less_x000D_
invasive or non-invasive methods are either prone to false-positives that require_x000D_
follow-up with colonoscopy or very expensive to be used as a screening tool. In this_x000D_
collaborative project, a team of academic researchers and clinicians will work together to_x000D_
develop a simple, litmus paper-like paper device for non-invasive detection of CRC. The test_x000D_
will be suited for routine CRC screening using stool samples. If successful, such a test will_x000D_
help save lives in Canada and around the world., agreement title english : Paper-based diagnostic device for colorectal cancer detection, agreement title french : Paper-based diagnostic device for colorectal cancer detection, agreement number : CHRPJ, agreement value : 402900.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada