Reference number : 172-2021-2022-Q4-988603, amendment number : 1, agreement type : G, recipient legal name : Université Laval, recipient country : CA, recipient province : QC, recipient city : Quebec|Québec, recipient postal code : G1V 0A6, program name english : Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives, program name french : Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D, program purpose english : Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas., program purpose french : Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires., agreement title english : Development of an AAV library, agreement title french : Développement d’une bibliothèque de virus associés aux adénovirus, agreement number : 988603, agreement value : 165000.0, agreement start date : 2022-03-29, agreement end date : 2024-09-30, description english : There are about 7,000 different hereditary diseases each due to the mutation of a gene. These genes are expressed in different cells. The treatment of these diseases requires the delivery of a normal gene or of gene modifying agents to the appropriate cells, i.e. those involved in the disease. Adeno-associated virus (AAV) is currently the most commonly used virus for the delivery of these components. However, delivery by AAVs is not sufficiently effective and specific for effective treatment of many hereditary diseases. Thus, the objective of this project is to modify the AAVs to produce some variants, which are more specific and more effective. The team’s approach is to modify the proteins, which are at the surface of the AAVs to change their binding to the proteins, sugar and lipids at the surface of target cells. This project will generate new AAV variants able to infect more effectively various types of cells to improve the efficacy of gene therapy, description french : Développement d’une bibliothèque de virus associés aux adénovirus, expected results english : In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems., expected results french : À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides., additional information english : This agreement has been amended 1 time(s). The end date of this agreement has been modified by 182 days., additional information french : Cet accord a été modifié 1 fois.  La date de fin du présent accord a été changé de 182 jours., owner organization : nrc-cnrc, owner organization title : National Research Council Canada | Conseil national de recherches Canada