Reference number : GC-2017-Q1-03301, amendment number : , agreement type : G, recipient legal name : Takano, Tomoko (McGill University)|Takano, Tomoko (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Epithelial cells are lining the walls of important structures in body organs such as lungs, intestines and the kidney. Our laboratory studies how the epithelial cells work, specifically focusing on the kidney. In response to injury, growth factors produced naturally in the kidney help the damaged epithelial cells to regenerate, in part by promoting the capacity of cells to divide and increase in numbers to replace dead cells. However, these newly regenerated cells need to regain sophisticated structure by the process called differentiation in order to restore their normal functions. We propose that a molecule called Dok-4 will help balance various regulators of the cell structure thereby contributing to the differentiation of epithelial cells. In this study, we will examine how Dok-4 is turned on at a certain stage of epithelial cell recovery and switches off one regulatory protein while switches on another regulatory protein of an opposing function. We expect that Dok-4 will act as a critical molecular switch which will direct the cells toward full recovery of function after an injury., program purpose french : Epithelial cells are lining the walls of important structures in body organs such as lungs, intestines and the kidney. Our laboratory studies how the epithelial cells work, specifically focusing on the kidney. In response to injury, growth factors produced naturally in the kidney help the damaged epithelial cells to regenerate, in part by promoting the capacity of cells to divide and increase in numbers to replace dead cells. However, these newly regenerated cells need to regain sophisticated structure by the process called differentiation in order to restore their normal functions. We propose that a molecule called Dok-4 will help balance various regulators of the cell structure thereby contributing to the differentiation of epithelial cells. In this study, we will examine how Dok-4 is turned on at a certain stage of epithelial cell recovery and switches off one regulatory protein while switches on another regulatory protein of an opposing function. We expect that Dok-4 will act as a critical molecular switch which will direct the cells toward full recovery of function after an injury., agreement title english : Regulation of Rho-GTPase pathways by the adaptor protein, Dok-4, agreement title french : Regulation of Rho-GTPase pathways by the adaptor protein, Dok-4, agreement number : RGPIN, agreement value : 26000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada