Reference number : GC-2017-Q1-00465, amendment number : , agreement type : G, recipient legal name : Leonenko, Zoya (University of Waterloo), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Sanofi Pasteur is developing novel vaccine products, which contain antigens adsorbed to different types of_x000D_
adjuvants. Characterization and comprehensive analysis of the antigen-adjuvant interactions is of great_x000D_
importance for this development. Traditional ways of characterization, however do not allow measurement of_x000D_
molecular forces acting between reagents on molecular level which is of key importance._x000D_
The proposed new collaboration between Sanofi Pasteur and Dr.Zoya Leonenko's laboratory at the University_x000D_
of Waterloo has a goal to characterize adjuvant-antigen interactions by advanced biophysical methods, such as_x000D_
Atomic force microscopy, atomic force spectroscopy, and surface plasmon resonance, which would enhance_x000D_
the knowledge of the forces involved in such interactions and would help in the understanding of the relevance_x000D_
of the strength of antigen adsorption to adjuvants in Sanofi Pasteur's vaccine products. This new knowledge_x000D_
will lead to new product development and will help to accelerate pharmaceutical research by providing an_x000D_
advanced vaccine thus will contribute to the improvement of health of Canadian and worldwide community., program purpose french : Sanofi Pasteur is developing novel vaccine products, which contain antigens adsorbed to different types of_x000D_
adjuvants. Characterization and comprehensive analysis of the antigen-adjuvant interactions is of great_x000D_
importance for this development. Traditional ways of characterization, however do not allow measurement of_x000D_
molecular forces acting between reagents on molecular level which is of key importance._x000D_
The proposed new collaboration between Sanofi Pasteur and Dr.Zoya Leonenko's laboratory at the University_x000D_
of Waterloo has a goal to characterize adjuvant-antigen interactions by advanced biophysical methods, such as_x000D_
Atomic force microscopy, atomic force spectroscopy, and surface plasmon resonance, which would enhance_x000D_
the knowledge of the forces involved in such interactions and would help in the understanding of the relevance_x000D_
of the strength of antigen adsorption to adjuvants in Sanofi Pasteur's vaccine products. This new knowledge_x000D_
will lead to new product development and will help to accelerate pharmaceutical research by providing an_x000D_
advanced vaccine thus will contribute to the improvement of health of Canadian and worldwide community., agreement title english : Characterization of Antigen-Adjuvant interactions by Atomic Force Microscopy, agreement title french : Characterization of Antigen-Adjuvant interactions by Atomic Force Microscopy, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada