Reference number : GC-2017-Q1-00249, amendment number : , agreement type : G, recipient legal name : Lerouge, Sophie (École de technologie supérieure), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Intervertebral discs allow slight movement of the vertebrae and play an important role in_x000D_
shock absorption in the spine but can be damaged with time. Disc degeneration is one of the_x000D_
leading causes of low back pain, which affects a large proportion of the global population at a_x000D_
huge socioeconomic burden. It is so common that approximately 1 in 50 Canadians become_x000D_
disabled by back pain._x000D_
When drugs or physical therapy are not sufficient, surgery is the only offered option which_x000D_
consists in the removal of the disc and/or its replacement by an implant. There is a clear need_x000D_
for minimally invasive repair of the intervertebral disc to avoid surgical treatment and long_x000D_
term complications which affect patients after simple removal of the disc._x000D_
The project aims to provide a minimally invasive treatment for damaged intervertebral discs_x000D_
based on the use of a material which can be injected into the disk through a needle and_x000D_
rapidly solidify. This material is combined with cells and bioactive products that can actively_x000D_
promote the reparation of the tissue, in order to better restore its mechanical properties and_x000D_
its normal composition. This injectable product should also have potential for the repair of_x000D_
cartilage, which affects an even higher number of patients._x000D_
Two Canadians companies are strongly interested in this product. Therefore, in addition to the_x000D_
improvement of the health of Canadians, this project will help reinforce the quite recent_x000D_
Canadian industry in this strategic field, program purpose french : Intervertebral discs allow slight movement of the vertebrae and play an important role in_x000D_
shock absorption in the spine but can be damaged with time. Disc degeneration is one of the_x000D_
leading causes of low back pain, which affects a large proportion of the global population at a_x000D_
huge socioeconomic burden. It is so common that approximately 1 in 50 Canadians become_x000D_
disabled by back pain._x000D_
When drugs or physical therapy are not sufficient, surgery is the only offered option which_x000D_
consists in the removal of the disc and/or its replacement by an implant. There is a clear need_x000D_
for minimally invasive repair of the intervertebral disc to avoid surgical treatment and long_x000D_
term complications which affect patients after simple removal of the disc._x000D_
The project aims to provide a minimally invasive treatment for damaged intervertebral discs_x000D_
based on the use of a material which can be injected into the disk through a needle and_x000D_
rapidly solidify. This material is combined with cells and bioactive products that can actively_x000D_
promote the reparation of the tissue, in order to better restore its mechanical properties and_x000D_
its normal composition. This injectable product should also have potential for the repair of_x000D_
cartilage, which affects an even higher number of patients._x000D_
Two Canadians companies are strongly interested in this product. Therefore, in addition to the_x000D_
improvement of the health of Canadians, this project will help reinforce the quite recent_x000D_
Canadian industry in this strategic field, agreement title english : Injectable bioactive hydrogel for the regeneration of intervertebral disc, agreement title french : Injectable bioactive hydrogel for the regeneration of intervertebral disc, agreement number : CHRPJ, agreement value : 298386.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada