Reference number : GC-2017-Q1-02914, amendment number : , agreement type : G, recipient legal name : Loewen, Christopher (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : The general objective of this research proposal is to define roles for lipids in the regulation of cellular metabolism. This research will enhance our understanding of basic fundamental mechanisms of lipid-mediated intracellular signalling and will identify new metabolic regulatory mechanisms important to all organisms. Presently, very little is known about the functions of lipids in these processes. The model organism Saccharomyces cerevisiae has proven to be an excellent model system for investigating the roles of lipids in cells because of the ease of genetic manipulation in this organism and the highly conserved nature of these pathways. Thus, many of the groundbreaking discoveries made in yeast have been highly applicable to higher organisms including humans. We will use sophisticated high-throughput yeast genetics to define cellular pathways that regulate phospholipid metabolism on a genome-wide scale. These studies will identify important new factors involved in the global control of lipid synthesis and uncover fundamental novel mechanisms of lipid-based signal transduction., program purpose french : The general objective of this research proposal is to define roles for lipids in the regulation of cellular metabolism. This research will enhance our understanding of basic fundamental mechanisms of lipid-mediated intracellular signalling and will identify new metabolic regulatory mechanisms important to all organisms. Presently, very little is known about the functions of lipids in these processes. The model organism Saccharomyces cerevisiae has proven to be an excellent model system for investigating the roles of lipids in cells because of the ease of genetic manipulation in this organism and the highly conserved nature of these pathways. Thus, many of the groundbreaking discoveries made in yeast have been highly applicable to higher organisms including humans. We will use sophisticated high-throughput yeast genetics to define cellular pathways that regulate phospholipid metabolism on a genome-wide scale. These studies will identify important new factors involved in the global control of lipid synthesis and uncover fundamental novel mechanisms of lipid-based signal transduction., agreement title english : Lipid signalling in yeast, agreement title french : Lipid signalling in yeast, agreement number : RGPIN, agreement value : 381000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada