Reference number : GC-2017-Q1-01839, amendment number : , agreement type : G, recipient legal name : Bagot, Rosemary (McGill University)|Bagot, Rosemary (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Learning about events that predict rewarding (e.g. palatable foods, sex) and aversive outcomes (e.g. predators, pain) and using this information to navigate through the environment is fundamental to survival. However, the significance of events is often not black and white but ambiguous and subject to interpretation and influenced by past experience. While a lot of research has examined how animals learn about positive and negative outcomes and the events that predict them, very little is known about how animals process ambiguity. This proposal focuses on a key question: how do animals resolve this ambiguity to optimize their behaviour in changing environments? There are considerable individual differences in how animals, respond to ambiguity, with some individuals having a propensity to interpret ambiguity in more positively and others more negatively (i.e. is the glass is half full or half empty?). The overarching goal of my research program (long-term objectives) is to uncover the biological basis of these individual differences and to understand how ambiguous events are represented within brain circuits, how this is changed by experience, and how activity within these specified brain circuits feeds back to shape future behaviour. To answer these questions we are using a mouse model of positive and negative bias where animals learn about positive and negative outcomes associated with specific cues and then are faced with previously un-encountered ambiguous cues. This specific research proposal (short-term objectives) uses two different kinds of early life experience (maternal separation or environmental enrichment) to examine how individual differences in responding to ambiguity alter neuronal activity in a key emotion/learning-related brain region sensitive to early life experience, the ventral hippocampus. 
This proposal has 3 specific questions: 
1. How do different kinds of early life experience (periods of isolation from litter; maternal separation, or exposure to stimulating toys; environmental enrichment) influence responding to ambiguity? 
2. How does activity in specific ensembles of neurons within the ventral hippocampus encode responses to ambiguity and how is this activity altered by experience? 
3. How do key ensembles of neurons that encode ambiguous events communicate with larger neuronal networks? 
This research will leverage individual differences (induced by early-life experience) to uncover neural mechanisms of behavioural response to ambiguous situations with each aim of this research program contributing unique and novel insight into how the brain processes ambiguity to allow animals to adaptively navigate their environment. The findings will inform our understanding of the psychological and neurobiological processes that guide behaviour in real-world situations where the meaning of events is rarely without some degree of ambiguity., program purpose french : Learning about events that predict rewarding (e.g. palatable foods, sex) and aversive outcomes (e.g. predators, pain) and using this information to navigate through the environment is fundamental to survival. However, the significance of events is often not black and white but ambiguous and subject to interpretation and influenced by past experience. While a lot of research has examined how animals learn about positive and negative outcomes and the events that predict them, very little is known about how animals process ambiguity. This proposal focuses on a key question: how do animals resolve this ambiguity to optimize their behaviour in changing environments? There are considerable individual differences in how animals, respond to ambiguity, with some individuals having a propensity to interpret ambiguity in more positively and others more negatively (i.e. is the glass is half full or half empty?). The overarching goal of my research program (long-term objectives) is to uncover the biological basis of these individual differences and to understand how ambiguous events are represented within brain circuits, how this is changed by experience, and how activity within these specified brain circuits feeds back to shape future behaviour. To answer these questions we are using a mouse model of positive and negative bias where animals learn about positive and negative outcomes associated with specific cues and then are faced with previously un-encountered ambiguous cues. This specific research proposal (short-term objectives) uses two different kinds of early life experience (maternal separation or environmental enrichment) to examine how individual differences in responding to ambiguity alter neuronal activity in a key emotion/learning-related brain region sensitive to early life experience, the ventral hippocampus. 
This proposal has 3 specific questions: 
1. How do different kinds of early life experience (periods of isolation from litter; maternal separation, or exposure to stimulating toys; environmental enrichment) influence responding to ambiguity? 
2. How does activity in specific ensembles of neurons within the ventral hippocampus encode responses to ambiguity and how is this activity altered by experience? 
3. How do key ensembles of neurons that encode ambiguous events communicate with larger neuronal networks? 
This research will leverage individual differences (induced by early-life experience) to uncover neural mechanisms of behavioural response to ambiguous situations with each aim of this research program contributing unique and novel insight into how the brain processes ambiguity to allow animals to adaptively navigate their environment. The findings will inform our understanding of the psychological and neurobiological processes that guide behaviour in real-world situations where the meaning of events is rarely without some degree of ambiguity., agreement title english : Neural correlates of individual differences in positive and negative bias, agreement title french : Neural correlates of individual differences in positive and negative bias, agreement number : RGPIN, agreement value : 185000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada