Reference number : GC-2017-Q2-04312, amendment number : , agreement type : G, recipient legal name : Cui, Bo (University of Waterloo), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Plus Grants for Universities, program name french : Subvention d'engagement partenarial Plus pour les universités, program purpose english : For transdermal drug delivery, skin fluid and blood extraction, the conventional stainless steel needle causes_x000D_
pain to the patients and is hard to be integrated with other medical devices at point-of-care-test fields. One_x000D_
solution to those limitations is micro-needle array because of its minimal invasive area/depth causing less pain_x000D_
and ability to be integrated with other micro-devices. Moreover, no cases of infection by micro-needles have_x000D_
been reported so far. Such micro-needles can be solid or hollow with a length of 100-900 µm and an external_x000D_
diameter of not more than 300 µm. The supporting company ExVivo Labs is pioneering novel point-of-care_x000D_
medical technologies for screening allergies. Its allergy test patches are based on extraction using micro-needle_x000D_
array of disease indicating biomarkers, such as immunoglobulin-E (IgE), which mediates type I hypersensitivity_x000D_
reactions, known as allergies. In the previous funded Engage project, we aimed to fabricate hollow silicon_x000D_
micro-needle array using MEMS microfabrication techniques, notably photolithography and deep silicon_x000D_
etching. The fabricated needles will be subsequently sharpened to under 10 micrometers for painless insertion_x000D_
into skin. In the current Engage Plus project, we aim to fabricate polymer hollow micro-needle array that is_x000D_
advantageous over silicon in certain aspects., program purpose french : For transdermal drug delivery, skin fluid and blood extraction, the conventional stainless steel needle causes_x000D_
pain to the patients and is hard to be integrated with other medical devices at point-of-care-test fields. One_x000D_
solution to those limitations is micro-needle array because of its minimal invasive area/depth causing less pain_x000D_
and ability to be integrated with other micro-devices. Moreover, no cases of infection by micro-needles have_x000D_
been reported so far. Such micro-needles can be solid or hollow with a length of 100-900 µm and an external_x000D_
diameter of not more than 300 µm. The supporting company ExVivo Labs is pioneering novel point-of-care_x000D_
medical technologies for screening allergies. Its allergy test patches are based on extraction using micro-needle_x000D_
array of disease indicating biomarkers, such as immunoglobulin-E (IgE), which mediates type I hypersensitivity_x000D_
reactions, known as allergies. In the previous funded Engage project, we aimed to fabricate hollow silicon_x000D_
micro-needle array using MEMS microfabrication techniques, notably photolithography and deep silicon_x000D_
etching. The fabricated needles will be subsequently sharpened to under 10 micrometers for painless insertion_x000D_
into skin. In the current Engage Plus project, we aim to fabricate polymer hollow micro-needle array that is_x000D_
advantageous over silicon in certain aspects., agreement title english : Fabrication of Polymer Hollow Microneedles for Transdermal Sample Extraction, agreement title french : Fabrication of Polymer Hollow Microneedles for Transdermal Sample Extraction, agreement number : EGP2, agreement value : 12500.0, agreement start date : 2017-09-20, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada