Reference number : GC-2017-Q1-02841, amendment number : , agreement type : G, recipient legal name : Ingham, Robert (University of Alberta), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : The cells of our body constantly receive and respond to signals from their surroundings. For example, cells of the immune system respond to invading bacteria and viruses by mounting an immune response, whereas developing neuron cells react to environmental cues to make the intricate cellular connections in our brains. Critical to the ability of cells to sense and respond to their environment are signalling pathways. 
 Signalling pathways consist of an array of biological molecules including proteins, lipids, RNA, and DNA. They perform the task of transmitting information within the cell, and allow cells to translate signals they receive from the environment into biological responses. My laboratory is interested in understanding how signalling molecules work together to elicit these responses. In particular, we strive to understand how the different molecules &ldquo;talk&rdquo; to each other in order to relay information within the cell. Through understanding how signal transduction pathways function we can address fundamental questions about how cells perceive and react to their environment. Moreover, since many diseases are caused by signalling pathways not functioning properly, our studies may provide insight into disease processes as well., program purpose french : The cells of our body constantly receive and respond to signals from their surroundings. For example, cells of the immune system respond to invading bacteria and viruses by mounting an immune response, whereas developing neuron cells react to environmental cues to make the intricate cellular connections in our brains. Critical to the ability of cells to sense and respond to their environment are signalling pathways. 
 Signalling pathways consist of an array of biological molecules including proteins, lipids, RNA, and DNA. They perform the task of transmitting information within the cell, and allow cells to translate signals they receive from the environment into biological responses. My laboratory is interested in understanding how signalling molecules work together to elicit these responses. In particular, we strive to understand how the different molecules &ldquo;talk&rdquo; to each other in order to relay information within the cell. Through understanding how signal transduction pathways function we can address fundamental questions about how cells perceive and react to their environment. Moreover, since many diseases are caused by signalling pathways not functioning properly, our studies may provide insight into disease processes as well., agreement title english : Elucidating the molecular mechanisms of signalling pathways, agreement title french : Elucidating the molecular mechanisms of signalling pathways, agreement number : RGPIN, agreement value : 130000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada