Reference number : GC-2017-Q4-00028, amendment number : , agreement type : G, recipient legal name : Ainslie, Philip (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Cerebral autoregulation is a protective mechanism that maintains optimal brain blood flow and oxygen delivery_x000D_
independent of changes in blood pressure. However, this protective mechanism has limits; blood pressures that_x000D_
are too high or too low may exceed the ability of the brain's autoregulation mechanism(s) leading to an_x000D_
excessive level of under- or over- perfusion. For example, in surgical patients, blood pressure often exceeds the_x000D_
upper and/or lower limits of cerebral autoregulation, yet clinicians may not recognize that the patient's cerebral_x000D_
perfusion is compromised and thus do not intervene. This issue stems from an absence of evidence based,_x000D_
standardized and effective technology that can be used to evaluate cerebral autoregulation, especially in_x000D_
real-time. Therefore, improved cerebral autoregulation monitoring technology capable of detecting and_x000D_
informing clinicians about the patient's cerebral autoregulation and brain blood flow is necessary. The first step_x000D_
to address this issue is the development of a standard for the improvement of cerebral autoregulation_x000D_
monitoring technology: the company (Medtronic) and University (Prof Ainslie) will be required to define and_x000D_
substantiate cerebral autoregulation monitoring approaches as part of a technology development process., program purpose french : Cerebral autoregulation is a protective mechanism that maintains optimal brain blood flow and oxygen delivery_x000D_
independent of changes in blood pressure. However, this protective mechanism has limits; blood pressures that_x000D_
are too high or too low may exceed the ability of the brain's autoregulation mechanism(s) leading to an_x000D_
excessive level of under- or over- perfusion. For example, in surgical patients, blood pressure often exceeds the_x000D_
upper and/or lower limits of cerebral autoregulation, yet clinicians may not recognize that the patient's cerebral_x000D_
perfusion is compromised and thus do not intervene. This issue stems from an absence of evidence based,_x000D_
standardized and effective technology that can be used to evaluate cerebral autoregulation, especially in_x000D_
real-time. Therefore, improved cerebral autoregulation monitoring technology capable of detecting and_x000D_
informing clinicians about the patient's cerebral autoregulation and brain blood flow is necessary. The first step_x000D_
to address this issue is the development of a standard for the improvement of cerebral autoregulation_x000D_
monitoring technology: the company (Medtronic) and University (Prof Ainslie) will be required to define and_x000D_
substantiate cerebral autoregulation monitoring approaches as part of a technology development process., agreement title english : Improvement of new technology for assessment of adequate cerebral blood perfusion, agreement title french : Improvement of new technology for assessment of adequate cerebral blood perfusion, agreement number : EGP, agreement value : 24000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada