Reference number : GC-2017-Q2-00428, amendment number : , agreement type : G, recipient legal name : Abolmaesumi, Purang (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Near-infrared spectroscopy (NIRS, also known as diffuse optical spectroscopy) is a technique that uses_x000D_
near-infrared light to measure blood flow and metabolism in body tissues like muscle and brain. NIRS is_x000D_
non-invasive, invisible to humans, and non-ionizing (that is, it does not cause cancer, unlike ultraviolet light)._x000D_
An important component of muscle metabolism during exercise is oxygen consumption, which scientists can_x000D_
measure in order to determine how muscle is responding to exercise and whether a person is benefiting from_x000D_
the exercise. One of the standard measurements of muscle oxygen use is the tissue oxygenation index, or TOI._x000D_
However, the methods used to determine TOI are not standardized across different NIRS instruments, and this_x000D_
limits both its wide applicability and the consistency of the assessments done by various laboratories and sport_x000D_
scientists. The goal of this research is to establish a new method for calculating TOI using the venous_x000D_
saturation in presence of cyclic motion. This will allow use of well established and validated techniques in_x000D_
pulse oximetry to be applied to NIRS. Venous saturation can be measured invasively which allows calibration_x000D_
of the method using a gold standard. This will improve the consistency and accuracy of NIRS instruments that_x000D_
are used for exercise testing in many settings., program purpose french : Near-infrared spectroscopy (NIRS, also known as diffuse optical spectroscopy) is a technique that uses_x000D_
near-infrared light to measure blood flow and metabolism in body tissues like muscle and brain. NIRS is_x000D_
non-invasive, invisible to humans, and non-ionizing (that is, it does not cause cancer, unlike ultraviolet light)._x000D_
An important component of muscle metabolism during exercise is oxygen consumption, which scientists can_x000D_
measure in order to determine how muscle is responding to exercise and whether a person is benefiting from_x000D_
the exercise. One of the standard measurements of muscle oxygen use is the tissue oxygenation index, or TOI._x000D_
However, the methods used to determine TOI are not standardized across different NIRS instruments, and this_x000D_
limits both its wide applicability and the consistency of the assessments done by various laboratories and sport_x000D_
scientists. The goal of this research is to establish a new method for calculating TOI using the venous_x000D_
saturation in presence of cyclic motion. This will allow use of well established and validated techniques in_x000D_
pulse oximetry to be applied to NIRS. Venous saturation can be measured invasively which allows calibration_x000D_
of the method using a gold standard. This will improve the consistency and accuracy of NIRS instruments that_x000D_
are used for exercise testing in many settings., agreement title english : Quantification of the real-time near-infrared spectroscopic tissue oxygenation index using venous saturation in presence of cyclic muscular motion, agreement title french : Quantification of the real-time near-infrared spectroscopic tissue oxygenation index using venous saturation in presence of cyclic muscular motion, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-08-23, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada