Reference number : 003-2024-2025-Q3-00003, amendment number : 1, agreement type : C, recipient legal name : University of Waterloo|Université de Waterloo, recipient country : CA, recipient province : ON, recipient city : Waterloo|Waterloo, recipient postal code : N2J0E2, program name english : Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology, program name french : Programme global de subventions et contributions à l'appui de la recherche, de la sensibilisation et de l'éducation en sciences et technologies spatiales, program purpose english : This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.

The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities., program purpose french : Ce programme appuie le développement des connaissances et l'innovation dans des domaines prioritaires de l'ASC et accroît la sensibilisation et la participation des Canadiens aux disciplines et aux activités liées à l'espace. 
Le volet Recherche vise à soutenir le développement des sciences et des technologies, à favoriser le développement continu d'une masse critique de chercheurs et de personnes hautement qualifiées au Canada, et à appuyer la collecte d'information, la recherche et les études relatives à l'espace en tenant compte des priorités de l'ASC., agreement title english : Manifestations of spaceflight-induced sub-clinical cardiovascular disease as a long-term health risk, agreement title french : Manifestations of spaceflight-induced sub-clinical cardiovascular disease as a long-term health risk, agreement number : 19NASAHER2, agreement value : 2805235.74, agreement start date : 2019-08-28, agreement end date : 2031-03-31, description english : Human spaceflight dramatically changes the daily exposures of the cardiovascular and musculo-skeletal systems to gravity
and physical loading. We will extend our previous observations of increased arterial stiffness and insulin resistance after 6-
month spaceflights to determine if 1-year in space exaggerates these conditions and promotes loss of calcium from bones
and uptake by arteries. Astronauts are extremely healthy on entry to space, but prolonged daily periods of physical
inactivity impair cardiometabolic and skeletal health. Our results should inform planning of physical countermeasures in
future long-duration explorations in space and convey the negative consequences of sedentary lifestyles in modern society., description french : Human spaceflight dramatically changes the daily exposures of the cardiovascular and musculo-skeletal systems to gravity
and physical loading. We will extend our previous observations of increased arterial stiffness and insulin resistance after 6-
month spaceflights to determine if 1-year in space exaggerates these conditions and promotes loss of calcium from bones
and uptake by arteries. Astronauts are extremely healthy on entry to space, but prolonged daily periods of physical
inactivity impair cardiometabolic and skeletal health. Our results should inform planning of physical countermeasures in
future long-duration explorations in space and convey the negative consequences of sedentary lifestyles in modern society., expected results english : The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future., expected results french : Le volet Recherche du programme offre aux organisations une aide financière qui leur permettra de mener leurs activités de recherche et développement spatiales dans des secteurs prioritaires. Ce volet appuiera le développement des connaissances et l’innovation dans les domaines ciblés de manière à soutenir et à accroître la capacité du Canada d’utiliser l’espace pour répondre aux besoins et aux priorités du pays dans le futur., additional information english : nan, additional information french : nan, owner organization : csa-asc, owner organization title : Canadian Space Agency | Agence spatiale canadienne