Reference number : GC-2017-Q3-00426, amendment number : , agreement type : G, recipient legal name : Sabatinos, Sarah (Ryerson University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : A Toronto-based company, Rna Diagnostics, has developed a test that determines whether chemotherapy is_x000D_
working. The test is based upon the level of RNA disruption in a tumour sample, and its computational_x000D_
analysis. RNA is copied from DNA, and increased RNA can help to cause tumour growth in cancer. RNA_x000D_
decay is a signal that chemotherapy is working and that tumour cells are dying. However, Rna Diagnostics_x000D_
would like to understand the pathways that cause RNA decay, and whether different levels of RNA disruption_x000D_
mean different drug effects or outcome.Dr. Sarah Sabatinos (Ryerson University, Toronto) will use yeast cells_x000D_
to test how RNA disruption happens after drug treatment. The Sabatinos lab will use microscopy to understand_x000D_
how RNA disruption happens, and test whether additional marks of chemotherapy effectiveness are present._x000D_
Our combined goal is to make Rna Diagnostics' tool better able to predict tumour cell death, and work earlier_x000D_
after drug is given. This work is important to promote training and improve diagnostics and predictive_x000D_
computational tools in Canada., program purpose french : A Toronto-based company, Rna Diagnostics, has developed a test that determines whether chemotherapy is_x000D_
working. The test is based upon the level of RNA disruption in a tumour sample, and its computational_x000D_
analysis. RNA is copied from DNA, and increased RNA can help to cause tumour growth in cancer. RNA_x000D_
decay is a signal that chemotherapy is working and that tumour cells are dying. However, Rna Diagnostics_x000D_
would like to understand the pathways that cause RNA decay, and whether different levels of RNA disruption_x000D_
mean different drug effects or outcome.Dr. Sarah Sabatinos (Ryerson University, Toronto) will use yeast cells_x000D_
to test how RNA disruption happens after drug treatment. The Sabatinos lab will use microscopy to understand_x000D_
how RNA disruption happens, and test whether additional marks of chemotherapy effectiveness are present._x000D_
Our combined goal is to make Rna Diagnostics' tool better able to predict tumour cell death, and work earlier_x000D_
after drug is given. This work is important to promote training and improve diagnostics and predictive_x000D_
computational tools in Canada., agreement title english : Typing and Targeting Mechanisms of RNA Decay Caused by Drug Treatment, agreement title french : Typing and Targeting Mechanisms of RNA Decay Caused by Drug Treatment, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-11-08, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada