Reference number : GC-2017-Q4-00291, amendment number : , agreement type : G, recipient legal name : Carmichael, Tricia (University of Windsor), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Inkbox is a company in Toronto that has commercialized the world's first two-week tattoo. This technology has_x000D_
ornamental applications, as well as exciting potential in medical applications. The key to this technology in an_x000D_
active ingredient derived from a fruit extract called Genipin, which has previously been explored as a non-toxic_x000D_
crosslinking reagent for tissue engineering and materials science. When Genipin is applied to the skin, it_x000D_
transforms into a vibrant blue colour. Although the chemistry behind this transformation is not well_x000D_
understood, it is believed to bind to the skin by reacting with amino acids, and then undergo further_x000D_
oligomerization reactions to form the vibrant blue colour of the tattoo. In this proposal, we will use a synthetic_x000D_
"skin mimic" to acquire a better understanding of this reaction process under controlled conditions. Our skin_x000D_
mimic will comprise a layer of molecules adhered to a solid surface that is amenable to advanced spectroscopic_x000D_
analysis. We will bind Genipin to the skin mimic and study its reactivity, using spectroscopic data to establish_x000D_
the binding as well as the subsequent reactions that cause the blue colouration of Inkbox tattoos. These studies_x000D_
will help Inkbox optimize its formulation to enhance skin penetration and increase tattoo longevity, and also_x000D_
provide insight into how intermolecular interactions may be able to alter the colouration of the product., program purpose french : Inkbox is a company in Toronto that has commercialized the world's first two-week tattoo. This technology has_x000D_
ornamental applications, as well as exciting potential in medical applications. The key to this technology in an_x000D_
active ingredient derived from a fruit extract called Genipin, which has previously been explored as a non-toxic_x000D_
crosslinking reagent for tissue engineering and materials science. When Genipin is applied to the skin, it_x000D_
transforms into a vibrant blue colour. Although the chemistry behind this transformation is not well_x000D_
understood, it is believed to bind to the skin by reacting with amino acids, and then undergo further_x000D_
oligomerization reactions to form the vibrant blue colour of the tattoo. In this proposal, we will use a synthetic_x000D_
"skin mimic" to acquire a better understanding of this reaction process under controlled conditions. Our skin_x000D_
mimic will comprise a layer of molecules adhered to a solid surface that is amenable to advanced spectroscopic_x000D_
analysis. We will bind Genipin to the skin mimic and study its reactivity, using spectroscopic data to establish_x000D_
the binding as well as the subsequent reactions that cause the blue colouration of Inkbox tattoos. These studies_x000D_
will help Inkbox optimize its formulation to enhance skin penetration and increase tattoo longevity, and also_x000D_
provide insight into how intermolecular interactions may be able to alter the colouration of the product., agreement title english : Probing the Dye Chemistry of Genipin-Based Temporary Tattoos Using a Self-Assembled Monolayer Skin Mimic, agreement title french : Probing the Dye Chemistry of Genipin-Based Temporary Tattoos Using a Self-Assembled Monolayer Skin Mimic, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada