Reference number : GC-2017-Q4-01619, amendment number : , agreement type : G, recipient legal name : Segura, Pedro Alejandro (Université de Sherbrooke), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Plus Grants for universities, program name french : Subvention d'engagement partenarial Plus pour les universités, program purpose english : Fast chemical analysis is in increasing demand in many fields. To reduce costs and deliver results promptly to_x000D_
patients, environmental and food safety agencies, analytical chemists rely on high-throughput technologies._x000D_
Phytronix Technologies (Quebec, QC) is a World leader in high-throughput analysis by tandem mass_x000D_
spectrometry. The company wishes to expand the market of its flagship product, the LDTD source, by_x000D_
increasing the number of small organic molecules that can be detected with it. The company has worked for_x000D_
years in the development of diverse approaches to improve sensitivity using the LDTD source. Phytronix does_x000D_
not have the human resources and time to work on systematic studies. Thanks to a previous Engage grant, we_x000D_
worked with Phytronix to develop an analytical method for the screening of environmental contaminants. Also,_x000D_
we successfully identified a new sample plate coating to improve the sensitivity of small molecules. We want_x000D_
to explore other surface coatings and try different fast derivatization procedures for small organic molecules of_x000D_
interest for Phytronix. Here we propose a 6-month project in which we will aim to: i) study the effect of_x000D_
coatings composed of biopolymers (proteins) that may improve sensitivity for problematic compounds in_x000D_
LDTD such as organic acids and amines; and ii) develop an alternative approach to improve thermal desorption_x000D_
and ionization of some small organic molecules by chemical derivatization. It is expected that our studies will_x000D_
yield more information on optimal sample plate coatings and derivatization conditions that will widen the_x000D_
number of compounds detectable by LDTD-MS/MS. We will work closely with R&D staff in order to_x000D_
maximize technology transfer and results that will be useful for Phytronix Technologies products and clients_x000D_
and we will use Phytronix's laboratory. Given the importance in Canada of chemical analysis in public health,_x000D_
conservation of the environment and protection of consumers, all Canadians will benefit of more efficient_x000D_
high-throughput technologies such as LDTD-MS/MS. Additionally, our work will give Phytronix the_x000D_
opportunity to expand to new markets and create new jobs in Canada., program purpose french : Fast chemical analysis is in increasing demand in many fields. To reduce costs and deliver results promptly to_x000D_
patients, environmental and food safety agencies, analytical chemists rely on high-throughput technologies._x000D_
Phytronix Technologies (Quebec, QC) is a World leader in high-throughput analysis by tandem mass_x000D_
spectrometry. The company wishes to expand the market of its flagship product, the LDTD source, by_x000D_
increasing the number of small organic molecules that can be detected with it. The company has worked for_x000D_
years in the development of diverse approaches to improve sensitivity using the LDTD source. Phytronix does_x000D_
not have the human resources and time to work on systematic studies. Thanks to a previous Engage grant, we_x000D_
worked with Phytronix to develop an analytical method for the screening of environmental contaminants. Also,_x000D_
we successfully identified a new sample plate coating to improve the sensitivity of small molecules. We want_x000D_
to explore other surface coatings and try different fast derivatization procedures for small organic molecules of_x000D_
interest for Phytronix. Here we propose a 6-month project in which we will aim to: i) study the effect of_x000D_
coatings composed of biopolymers (proteins) that may improve sensitivity for problematic compounds in_x000D_
LDTD such as organic acids and amines; and ii) develop an alternative approach to improve thermal desorption_x000D_
and ionization of some small organic molecules by chemical derivatization. It is expected that our studies will_x000D_
yield more information on optimal sample plate coatings and derivatization conditions that will widen the_x000D_
number of compounds detectable by LDTD-MS/MS. We will work closely with R&D staff in order to_x000D_
maximize technology transfer and results that will be useful for Phytronix Technologies products and clients_x000D_
and we will use Phytronix's laboratory. Given the importance in Canada of chemical analysis in public health,_x000D_
conservation of the environment and protection of consumers, all Canadians will benefit of more efficient_x000D_
high-throughput technologies such as LDTD-MS/MS. Additionally, our work will give Phytronix the_x000D_
opportunity to expand to new markets and create new jobs in Canada., agreement title english : New approaches to improve thermal desorption of small organic molecules by LDTD-MS/MS, agreement title french : New approaches to improve thermal desorption of small organic molecules by LDTD-MS/MS, agreement number : EGP2, agreement value : 12500.0, agreement start date : 2018-01-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada