Reference number : GC-2017-Q1-03544, amendment number : , agreement type : G, recipient legal name : Rosa-Neto, Pedro (McGill University)|Rosa-Neto, Pedro (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Positron Emission Tomography (PET) associated to radiopharmaceuticals constitutes an ideal non-invasive imaging method for quantification of brain neurodegenerative processes. AIMS: The aims of the present research is to develop novel technologies for in vivo quantification brain molecular processes using PET imaging agents as well as magnetic resonance imaging (MRI) techniques. These goals entail two major milestones. Firstly, proof of concept studies conducted in vitro preparations as well as in animal models. Subsequently further studies will validate these novel methodologies in living animals for KAL-ABP, MNI-387, [11C]PBR28, [18F]MK6240, [18F]FEOBV to measure microglia activation, protein aggregates and cholinergic transport. DELIVERABLES: This research program will (1) characterize the binding of novel radiopharmaceuticals in vitro (2) provide proof of concept data conducted in in animal models; (3) Furthermore, the present research program incorporates the training of high-qualified personal to conduct, analyze and interpret and integrate imaging to behavior outcome measures. To this end, our Canadian Foundation for Innovation (CFI) funded imaging laboratory provides a unique environment for trainees and students to conduct of in vitro imaging. Furthermore our laboratory infrastructure is integrated to in vivo data acquisition core facilities such as the Douglas Imaging Centre (MRI acquisition), Douglas neurophenotype unit (animal behavioral measures) and the Montreal neurological Institute Brain Imaging Centre (PET acquisition). FORMATION OF HUMAN RESOURCES: the project will provide a unique training environment for junior scientists, engineers and neuroinformatics professionals interested in developing in vivo methodologies for monitoring brain function. IMPACT: Novel technologies capable to capture non invasively aging-related processes in normal individuals constitute one of the major challenges in biomedicine, which will ultimately expands the comprehension of mechanisms underlying healthy aging., program purpose french : Positron Emission Tomography (PET) associated to radiopharmaceuticals constitutes an ideal non-invasive imaging method for quantification of brain neurodegenerative processes. AIMS: The aims of the present research is to develop novel technologies for in vivo quantification brain molecular processes using PET imaging agents as well as magnetic resonance imaging (MRI) techniques. These goals entail two major milestones. Firstly, proof of concept studies conducted in vitro preparations as well as in animal models. Subsequently further studies will validate these novel methodologies in living animals for KAL-ABP, MNI-387, [11C]PBR28, [18F]MK6240, [18F]FEOBV to measure microglia activation, protein aggregates and cholinergic transport. DELIVERABLES: This research program will (1) characterize the binding of novel radiopharmaceuticals in vitro (2) provide proof of concept data conducted in in animal models; (3) Furthermore, the present research program incorporates the training of high-qualified personal to conduct, analyze and interpret and integrate imaging to behavior outcome measures. To this end, our Canadian Foundation for Innovation (CFI) funded imaging laboratory provides a unique environment for trainees and students to conduct of in vitro imaging. Furthermore our laboratory infrastructure is integrated to in vivo data acquisition core facilities such as the Douglas Imaging Centre (MRI acquisition), Douglas neurophenotype unit (animal behavioral measures) and the Montreal neurological Institute Brain Imaging Centre (PET acquisition). FORMATION OF HUMAN RESOURCES: the project will provide a unique training environment for junior scientists, engineers and neuroinformatics professionals interested in developing in vivo methodologies for monitoring brain function. IMPACT: Novel technologies capable to capture non invasively aging-related processes in normal individuals constitute one of the major challenges in biomedicine, which will ultimately expands the comprehension of mechanisms underlying healthy aging., agreement title english : Modeling imaging data, agreement title french : Modeling imaging data, agreement number : RGPIN, agreement value : 21000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada