Reference number : GC-2017-Q1-02836, amendment number : , agreement type : G, recipient legal name : Blank, Volker (McGill University)|Blank, Volker (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Transcription factors are important molecules that control whether genes are active or not in a specific cell within an organism. We are interested in the function of the MAFF transcription factor in mammalian cells. In previous studies we have found that signaling molecules called cytokines control MAFF levels in the cell. In recent studies, we showed that the MAFF protein itself is also modified. In addition, we identified a specific gene that is directly controlled by the MAFF transcription factor. This gene plays important roles in a variety of cellular processes as for example the migration of cells. We will use our new knowledge to gain a better understanding of MAFF function. We hypothesize that 1) protein-protein interactions and protein modifications are important to regulate MAFF activity and that 2) In MAFF regulates key processes in the cell by controlling its target genes. We will use a series of molecular and biochemical approaches in combination with cutting edge technology to determine how interactions with other proteins and modifications modulate MAFF transcription factor activity. Furthermore, we will dissect how MAFF controls the expression of genes. Our overall objective is to elucidate the fundamental molecular mechanisms that govern transcriptional regulation. Our research is aimed to gain fundamental insights into MAFF transcription factor biology and thus will help to better understand the basic molecular processes that govern cellular function in living organisms., program purpose french : Transcription factors are important molecules that control whether genes are active or not in a specific cell within an organism. We are interested in the function of the MAFF transcription factor in mammalian cells. In previous studies we have found that signaling molecules called cytokines control MAFF levels in the cell. In recent studies, we showed that the MAFF protein itself is also modified. In addition, we identified a specific gene that is directly controlled by the MAFF transcription factor. This gene plays important roles in a variety of cellular processes as for example the migration of cells. We will use our new knowledge to gain a better understanding of MAFF function. We hypothesize that 1) protein-protein interactions and protein modifications are important to regulate MAFF activity and that 2) In MAFF regulates key processes in the cell by controlling its target genes. We will use a series of molecular and biochemical approaches in combination with cutting edge technology to determine how interactions with other proteins and modifications modulate MAFF transcription factor activity. Furthermore, we will dissect how MAFF controls the expression of genes. Our overall objective is to elucidate the fundamental molecular mechanisms that govern transcriptional regulation. Our research is aimed to gain fundamental insights into MAFF transcription factor biology and thus will help to better understand the basic molecular processes that govern cellular function in living organisms., agreement title english : Molecular mechanisms governing small MAF protein function in mammals, agreement title french : Molecular mechanisms governing small MAF protein function in mammals, agreement number : RGPIN, agreement value : 130000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada