Reference number : GC-2017-Q4-00061, amendment number : , agreement type : G, recipient legal name : Aranda Saldaña, Marleny Doris (University of Alberta), recipient country : CA, recipient province : nan, recipient city : Alberta, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Rhodiola rosea is an herbaceous plant found in the Arctic region and Alberta that has traditionally been used_x000D_
for medicinal purposes. Various studies have demonstrated the bioactivity of Rhodiola rosea in several areas of_x000D_
health, including stress and cancer, among others. Of interest in terms of therapeutic effectiveness are its_x000D_
rosavin compounds. Different solvent extraction methodologies have been used to isolate rosavin from_x000D_
Rhodiola rosea roots. However, with these existing extracts the amount and purity of the resulting rosavin in_x000D_
terms of both quality and yield remain a significant challenge. Also, little is known about the extraction of the_x000D_
rosin and rosarin components of this bioactive complex collectively called rosavins. The main objective of this_x000D_
project is to use supercritical CO2 extraction, an environmentally-friendly "green" technology, to extract_x000D_
rosavins, i.e. rosavin, rosin and rosarin, from Rhodiola rosea roots provided by St. Francis Herb Farm Inc._x000D_
Supercritical extraction using carbon dioxide as the solvent allows easy separation of the solvent from the_x000D_
extracted rosavin, rosin, and rosarin, leaving a product that is easy to characterize. Results from supercritical_x000D_
extraction will be compared to conventional solvent extraction in terms of both yield and product quality. A_x000D_
high yield of pure rosavin, rosin, and rosarin will allow their further commercialization as ingredients of natural_x000D_
health products produced in Canada and will strengthen Canada's agricultural sector. The successful extraction_x000D_
and commercialization of rosavin, rosin, and rosarin also has the social benefit of potentially providing an_x000D_
affordable treatment for hot flashes, stress, and depression to a large segment of women and men affected by_x000D_
these health issues worldwide., program purpose french : Rhodiola rosea is an herbaceous plant found in the Arctic region and Alberta that has traditionally been used_x000D_
for medicinal purposes. Various studies have demonstrated the bioactivity of Rhodiola rosea in several areas of_x000D_
health, including stress and cancer, among others. Of interest in terms of therapeutic effectiveness are its_x000D_
rosavin compounds. Different solvent extraction methodologies have been used to isolate rosavin from_x000D_
Rhodiola rosea roots. However, with these existing extracts the amount and purity of the resulting rosavin in_x000D_
terms of both quality and yield remain a significant challenge. Also, little is known about the extraction of the_x000D_
rosin and rosarin components of this bioactive complex collectively called rosavins. The main objective of this_x000D_
project is to use supercritical CO2 extraction, an environmentally-friendly "green" technology, to extract_x000D_
rosavins, i.e. rosavin, rosin and rosarin, from Rhodiola rosea roots provided by St. Francis Herb Farm Inc._x000D_
Supercritical extraction using carbon dioxide as the solvent allows easy separation of the solvent from the_x000D_
extracted rosavin, rosin, and rosarin, leaving a product that is easy to characterize. Results from supercritical_x000D_
extraction will be compared to conventional solvent extraction in terms of both yield and product quality. A_x000D_
high yield of pure rosavin, rosin, and rosarin will allow their further commercialization as ingredients of natural_x000D_
health products produced in Canada and will strengthen Canada's agricultural sector. The successful extraction_x000D_
and commercialization of rosavin, rosin, and rosarin also has the social benefit of potentially providing an_x000D_
affordable treatment for hot flashes, stress, and depression to a large segment of women and men affected by_x000D_
these health issues worldwide., agreement title english : Extraction of rosavin, rosin and rosarin from Rhodiola rosea roots using supercritical CO2, agreement title french : Extraction of rosavin, rosin and rosarin from Rhodiola rosea roots using supercritical CO2, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada