Reference number : GC-2017-Q4-00733, amendment number : , agreement type : G, recipient legal name : Hallam, Steven (The University of British Columbia), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Regulating the metabolic expression of photosynthetic microorganisms offers the possibility of producing_x000D_
high-value chemicals directly from sunlight, water and carbon dioxide. Despite a plethora of phenotypic and_x000D_
molecular information, only a few cyanobacterial isolates have been developed into tractable genetic systems_x000D_
with associated genome-scale metabolic models. This limits the number of strains that can be used as platform_x000D_
chemical producers. AlgaBloom International, a Vancouver-based biotech company specializing in bioreactor_x000D_
design and cynaobacterial cell growth, is interested in developing their specific strain of Spirulina, optimized_x000D_
for high growth yields, as a platform chemical producer to extend their market range and profitability. Through_x000D_
the application of genome-scale metabolic modeling techniques and controlled laboratory growth experiments,_x000D_
this project aims to redirect metabolite flow through desired biosynthetic pathways in Spirulina. During this_x000D_
phase of the project we will specifically focus on genome sequencing and model directed over-production of_x000D_
phycocyanin, a valuable photosynthetic pigment with multiple applications in the food, medical and_x000D_
instrumentation industries. Predicted overproduction phenotypes will be tested at both bench- and pilot-scales_x000D_
and an optimized phycocyanin extraction and purification protocol will be developed for AlgaBloom., program purpose french : Regulating the metabolic expression of photosynthetic microorganisms offers the possibility of producing_x000D_
high-value chemicals directly from sunlight, water and carbon dioxide. Despite a plethora of phenotypic and_x000D_
molecular information, only a few cyanobacterial isolates have been developed into tractable genetic systems_x000D_
with associated genome-scale metabolic models. This limits the number of strains that can be used as platform_x000D_
chemical producers. AlgaBloom International, a Vancouver-based biotech company specializing in bioreactor_x000D_
design and cynaobacterial cell growth, is interested in developing their specific strain of Spirulina, optimized_x000D_
for high growth yields, as a platform chemical producer to extend their market range and profitability. Through_x000D_
the application of genome-scale metabolic modeling techniques and controlled laboratory growth experiments,_x000D_
this project aims to redirect metabolite flow through desired biosynthetic pathways in Spirulina. During this_x000D_
phase of the project we will specifically focus on genome sequencing and model directed over-production of_x000D_
phycocyanin, a valuable photosynthetic pigment with multiple applications in the food, medical and_x000D_
instrumentation industries. Predicted overproduction phenotypes will be tested at both bench- and pilot-scales_x000D_
and an optimized phycocyanin extraction and purification protocol will be developed for AlgaBloom., agreement title english : Model directed phycocyanin over-production in blooming algal cell-factories, agreement title french : Model directed phycocyanin over-production in blooming algal cell-factories, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada