Reference number : GC-2017-Q1-03450, amendment number : , agreement type : G, recipient legal name : Kadem, Lyes (Concordia University)|Kadem, Lyes (Université Concordia), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : Cardiovascular disease is currently responsible for more than 17 million deaths per year worldwide, corresponding to about 30% of all deaths combined. Furthermore, it is projected that cardiovascular disease is to remain the leading cause of mortality by 2030. In order to restrain the negative impacts of cardiovascular disease on the population and the economy, there is an urgent need to promote innovation in medical devices. However, despite a consistent annual growth of the Canadian medical device industries, their market share remains very low. This is part due to the lack of sufficient medical device expertise and skills. This proposed research program has the potential to significantly contribute towards resolving this gap. This is by generating unique knowledge and data that should trigger innovation in implantable medical devices and train highly qualified personnel with strong fundamental knowledge and skills in cardiovascular fluid dynamics applied to implantable medical devices. The proposed research program is designed around three main research axes. In the research axis#1, we will determine experimentally the range of anatomical and flow design parameters associated with optimal flow performance in heart cavities. This is expected to lead to significant advances in the design of new innovative left ventricle assist devices and 3D bioprinting of artificial organs. In the research axis#2, we will investigate, experimentally and mathematically, the complex flow dynamics in heart cavities in the presence of mixed and multiple valve pathologies in order to advance our knowledge on the real flow environment of implantable medical devices and optimize their testing and selection criteria. In the research axis#3, we will be developing the next-generation of cardiac simulators based on patient-specific data and anatomy: &ldquo;3D-printed patient clones&rdquo;. The expected impact will be a significant advancement in close-to-real testing of implantable medical devices. This research program has the potential to contribute towards improving current guidelines and standards for market approval of implantable medical devices, lowering the costs of development and promoting innovation in Canada., program purpose french : Cardiovascular disease is currently responsible for more than 17 million deaths per year worldwide, corresponding to about 30% of all deaths combined. Furthermore, it is projected that cardiovascular disease is to remain the leading cause of mortality by 2030. In order to restrain the negative impacts of cardiovascular disease on the population and the economy, there is an urgent need to promote innovation in medical devices. However, despite a consistent annual growth of the Canadian medical device industries, their market share remains very low. This is part due to the lack of sufficient medical device expertise and skills. This proposed research program has the potential to significantly contribute towards resolving this gap. This is by generating unique knowledge and data that should trigger innovation in implantable medical devices and train highly qualified personnel with strong fundamental knowledge and skills in cardiovascular fluid dynamics applied to implantable medical devices. The proposed research program is designed around three main research axes. In the research axis#1, we will determine experimentally the range of anatomical and flow design parameters associated with optimal flow performance in heart cavities. This is expected to lead to significant advances in the design of new innovative left ventricle assist devices and 3D bioprinting of artificial organs. In the research axis#2, we will investigate, experimentally and mathematically, the complex flow dynamics in heart cavities in the presence of mixed and multiple valve pathologies in order to advance our knowledge on the real flow environment of implantable medical devices and optimize their testing and selection criteria. In the research axis#3, we will be developing the next-generation of cardiac simulators based on patient-specific data and anatomy: &ldquo;3D-printed patient clones&rdquo;. The expected impact will be a significant advancement in close-to-real testing of implantable medical devices. This research program has the potential to contribute towards improving current guidelines and standards for market approval of implantable medical devices, lowering the costs of development and promoting innovation in Canada., agreement title english : Optimal and Sub-Optimal Flow Configurations in the Heart: Application to Implantable Medical Devices, agreement title french : Optimal and Sub-Optimal Flow Configurations in the Heart: Application to Implantable Medical Devices, agreement number : RGPIN, agreement value : 185000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada