Reference number : GC-2017-Q1-00448, amendment number : , agreement type : G, recipient legal name : Novog, David (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Over the last 40 years the improvement in medical isotopes has allowed for the effective treatments of many_x000D_
types of cancer through the continuous development of both new isotopes and new delivery mechanisms. ABK_x000D_
Biomedical is developing a suite of imageable embolic microspheres for the treatment of some cancers. One of_x000D_
their products is a new and unique method of isotope delivery directly to the affected cells involves the precise_x000D_
and localized injection of radioactive materials within micro-sized spheres to a cancerous region. The_x000D_
production process involves taking non-radioactive spheres containing suitable target isotopes and packing_x000D_
them into a relatively small volume and then activating them in a nuclear reactor. Due to neutron and gamma_x000D_
radiation interaction with these spheres each undergoes volumetric heating from the energy deposited in these_x000D_
interactions. Depending on the materials, sphere geometry, irradiation time and neutron/gamma fields in the_x000D_
reactor, the heat deposited in the spheres may be significant, and possibly exceed the heat removal capacity of_x000D_
the assembly. In such cases the spheres will melt resulting in a loss of the batch of isotopes being irradiated._x000D_
ABK Biomedical wishes to develop the irradiation protocols such as to maximize their production output. This_x000D_
project will develop and tests new tools and methods for the simulation of such embolic spheres and attempt to_x000D_
develop more robust irradiation methods where production can be maximized., program purpose french : Over the last 40 years the improvement in medical isotopes has allowed for the effective treatments of many_x000D_
types of cancer through the continuous development of both new isotopes and new delivery mechanisms. ABK_x000D_
Biomedical is developing a suite of imageable embolic microspheres for the treatment of some cancers. One of_x000D_
their products is a new and unique method of isotope delivery directly to the affected cells involves the precise_x000D_
and localized injection of radioactive materials within micro-sized spheres to a cancerous region. The_x000D_
production process involves taking non-radioactive spheres containing suitable target isotopes and packing_x000D_
them into a relatively small volume and then activating them in a nuclear reactor. Due to neutron and gamma_x000D_
radiation interaction with these spheres each undergoes volumetric heating from the energy deposited in these_x000D_
interactions. Depending on the materials, sphere geometry, irradiation time and neutron/gamma fields in the_x000D_
reactor, the heat deposited in the spheres may be significant, and possibly exceed the heat removal capacity of_x000D_
the assembly. In such cases the spheres will melt resulting in a loss of the batch of isotopes being irradiated._x000D_
ABK Biomedical wishes to develop the irradiation protocols such as to maximize their production output. This_x000D_
project will develop and tests new tools and methods for the simulation of such embolic spheres and attempt to_x000D_
develop more robust irradiation methods where production can be maximized., agreement title english : Analysis of Heat Loads During Production of Radioactive Medical Isotopes, agreement title french : Analysis of Heat Loads During Production of Radioactive Medical Isotopes, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-06-14, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada