Reference number : GC-2017-Q4-00786, amendment number : , agreement type : G, recipient legal name : Hof, Fraser (University of Victoria), recipient country : CA, recipient province : nan, recipient city : British Columbia|Colombie-Britannique, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : This project aims to identify a family of molecules that can generally bind to conserved binding pockets in_x000D_
epigenetic proteins. These molecules (called bioisosteres) would be generally useful starting points for_x000D_
epigenetic drug development efforts, as well as valuable tools for basic research into epigenetic modulators._x000D_
ChemRoutes has a family of scaffold molecules - called ChemCores - that are potentially well suited to bind to_x000D_
epigenetic methyl reader pockets. The Hof lab at UVic are world leaders in the development of biochemical_x000D_
assays for binding to such proteins. The proposal is first to establish a panel of fluorescence polarization assays_x000D_
for five distinct methyl reader proteins, and then to run three series of proprietary compounds prepared by_x000D_
ChemRoutes through the panel of assays. The project will identify novel bioisosteres that ChemRoutes will be_x000D_
able to leverage in further research efforts and partnerships towards epigenetic modulation., program purpose french : This project aims to identify a family of molecules that can generally bind to conserved binding pockets in_x000D_
epigenetic proteins. These molecules (called bioisosteres) would be generally useful starting points for_x000D_
epigenetic drug development efforts, as well as valuable tools for basic research into epigenetic modulators._x000D_
ChemRoutes has a family of scaffold molecules - called ChemCores - that are potentially well suited to bind to_x000D_
epigenetic methyl reader pockets. The Hof lab at UVic are world leaders in the development of biochemical_x000D_
assays for binding to such proteins. The proposal is first to establish a panel of fluorescence polarization assays_x000D_
for five distinct methyl reader proteins, and then to run three series of proprietary compounds prepared by_x000D_
ChemRoutes through the panel of assays. The project will identify novel bioisosteres that ChemRoutes will be_x000D_
able to leverage in further research efforts and partnerships towards epigenetic modulation., agreement title english : Identifying bioisosteres for cationic epigenetic motifs, agreement title french : Identifying bioisosteres for cationic epigenetic motifs, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada