Reference number : GC-2017-Q3-00591, amendment number : , agreement type : G, recipient legal name : Girard-Lauriault, Pierre-Luc (McGill University)|Girard-Lauriault, Pierre-Luc (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The performance of implantable medical devices can often be improved by a surface engineering procedure_x000D_
allowing to either tune the surface chemistry to improve interactions with surrounding biological media or to_x000D_
graft active elements that will have a direct effect. Our laboratory has developed a flexible surface engineering_x000D_
procedure that can achieve either of these effects. We use cold plasma (an ionized gas produced as an_x000D_
electrical discharge) to deposit organic coatings containing nitrogen, oxygen and sulfur functional groups. Our_x000D_
method is to mix a film forming gas, such as ethylene, with a source of heteroatom, such at ammonia, and to_x000D_
activate those gasses in a plasma to trigger the formation of organic coatings. The properties of these organic_x000D_
coatings can be adjusted with the process parameters, such as gas composition. The functional groups in the_x000D_
coatings can either indirectly affect cell processes by governing protein adhesion or be used as chemical_x000D_
anchors to covalently bond active molecules._x000D_
Our proposed industrial partner, Phagelux (Canada) Inc. has developed a technology to attach bacteriophages to_x000D_
the surface of titanium implants to prevent infection following implantation. They have used plasma deposited_x000D_
organic coating to favor the attachment of the phages. However, their method involves toxic and corrosive_x000D_
gasses offering limited adjustability in terms of coating properties. Moreover, they have limited accessibility to_x000D_
the method as it is done through an international subcontractant. We propose a research collaboration to_x000D_
develop and optimize a procedure to attach bacteriophages to titanium samples using our highly tunable plasma_x000D_
polymerized coatings. The development of a successful procedure would initiate a long-term collaboration_x000D_
involving in-vivo testing of the titanium implants while Phagelux expands its research activities in Canada., program purpose french : The performance of implantable medical devices can often be improved by a surface engineering procedure_x000D_
allowing to either tune the surface chemistry to improve interactions with surrounding biological media or to_x000D_
graft active elements that will have a direct effect. Our laboratory has developed a flexible surface engineering_x000D_
procedure that can achieve either of these effects. We use cold plasma (an ionized gas produced as an_x000D_
electrical discharge) to deposit organic coatings containing nitrogen, oxygen and sulfur functional groups. Our_x000D_
method is to mix a film forming gas, such as ethylene, with a source of heteroatom, such at ammonia, and to_x000D_
activate those gasses in a plasma to trigger the formation of organic coatings. The properties of these organic_x000D_
coatings can be adjusted with the process parameters, such as gas composition. The functional groups in the_x000D_
coatings can either indirectly affect cell processes by governing protein adhesion or be used as chemical_x000D_
anchors to covalently bond active molecules._x000D_
Our proposed industrial partner, Phagelux (Canada) Inc. has developed a technology to attach bacteriophages to_x000D_
the surface of titanium implants to prevent infection following implantation. They have used plasma deposited_x000D_
organic coating to favor the attachment of the phages. However, their method involves toxic and corrosive_x000D_
gasses offering limited adjustability in terms of coating properties. Moreover, they have limited accessibility to_x000D_
the method as it is done through an international subcontractant. We propose a research collaboration to_x000D_
develop and optimize a procedure to attach bacteriophages to titanium samples using our highly tunable plasma_x000D_
polymerized coatings. The development of a successful procedure would initiate a long-term collaboration_x000D_
involving in-vivo testing of the titanium implants while Phagelux expands its research activities in Canada., agreement title english : Immobilization of bacteriophages on implants with plasma deposited organic coatings, agreement title french : Immobilization of bacteriophages on implants with plasma deposited organic coatings, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-10-18, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada