Reference number : GC-2017-Q4-00471, amendment number : , agreement type : G, recipient legal name : Didar, Tohid (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The aim of this project is to offer a cost-effective strategy for attaching proteins to glass and plastic substrates (the main substrates_x000D_
that SQI Diagnostics currently uses) that are stable, functional and properly bond to the substrates. This project will have three_x000D_
main steps toward reaching this goal: (A) Surface functionalization, (B) Protein immobilization and (C) Bio-functionality_x000D_
assessment._x000D_
We propose to investigate several functional chemistries on the surfaces for stable and covalent attachment of biomolecules. We_x000D_
also propose several methods for the immobilization of biomolecules onto the surfaces such as conventional liquid phase coating_x000D_
as well as automated printings for immobilizing SQI's desired biomolecules. As controls, we will also investigate physical_x000D_
patterning of the biomolecules on the surface without covalent attachment as well as using the same functional surfaces that the_x000D_
company is currently using. To demonstrate the bio-functionality, the coatings will be optimized using the currently available_x000D_
bioassays at SQI., program purpose french : The aim of this project is to offer a cost-effective strategy for attaching proteins to glass and plastic substrates (the main substrates_x000D_
that SQI Diagnostics currently uses) that are stable, functional and properly bond to the substrates. This project will have three_x000D_
main steps toward reaching this goal: (A) Surface functionalization, (B) Protein immobilization and (C) Bio-functionality_x000D_
assessment._x000D_
We propose to investigate several functional chemistries on the surfaces for stable and covalent attachment of biomolecules. We_x000D_
also propose several methods for the immobilization of biomolecules onto the surfaces such as conventional liquid phase coating_x000D_
as well as automated printings for immobilizing SQI's desired biomolecules. As controls, we will also investigate physical_x000D_
patterning of the biomolecules on the surface without covalent attachment as well as using the same functional surfaces that the_x000D_
company is currently using. To demonstrate the bio-functionality, the coatings will be optimized using the currently available_x000D_
bioassays at SQI., agreement title english : Investigating optimal surface coating strtegies for linking SQI scapture probes on plastic amd glass subtrates, agreement title french : Investigating optimal surface coating strtegies for linking SQI scapture probes on plastic amd glass subtrates, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-22, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada