Reference number : GC-2017-Q4-01488, amendment number : , agreement type : G, recipient legal name : Puri, Ishwar (McMaster University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Research and Development Grants - Project, program name french : Subventions de recherche et développement coopérative - projet, program purpose english : Canada's increasing aging population is confronted by a lack of timely diagnosis for various autoimmune_x000D_
diseases with turnaround times varying from a few days to weeks, leading to rising healthcare costs with_x000D_
unfavorable economic and societal implications. Traditional methods for disease detection rely on a single test_x000D_
at a time. Our industry partner, SQI Diagnostics (SQID) develops automated multiplexed assays capable of_x000D_
performing multiple tests at the same time. Such systems are ideal for high volume high throughput testing_x000D_
facilities, but these are yet uneconomical for local testing facilities or point of care/testing devices. We recently_x000D_
demonstrated the working principle of a novel cost-effective, reliable and sensitive chemiresistive biosensor_x000D_
that is capable of rapidly detecting biomarkers within a minute. We propose to develop a multiplexed_x000D_
biosensing platform based on magnetic bio-inks that could be used in hospitals, reference labs and other similar_x000D_
healthcare institutions. This will be achieved by (1) developing magnetic bio-inks, (2) evaluating the_x000D_
performance biosensors printed with these inks, (3) comparing their performance with standard tests, and (4)_x000D_
developing multiplexing capabilities for the biosensor. We will follow this by scaling up the printing of_x000D_
diagnostic sensing strips and integrating them into devices that can be used to develop marketable products._x000D_
SQID will license and commercialize the technology, translating the research into a point of care/testing_x000D_
devices. The outcome of the proposed work promises significant commercial benefits to Canada through the_x000D_
creation of ~30 jobs and improved global presence in the healthcare industry. The project will also advance_x000D_
scientific understanding of chemiresistive biosensors., program purpose french : Canada's increasing aging population is confronted by a lack of timely diagnosis for various autoimmune_x000D_
diseases with turnaround times varying from a few days to weeks, leading to rising healthcare costs with_x000D_
unfavorable economic and societal implications. Traditional methods for disease detection rely on a single test_x000D_
at a time. Our industry partner, SQI Diagnostics (SQID) develops automated multiplexed assays capable of_x000D_
performing multiple tests at the same time. Such systems are ideal for high volume high throughput testing_x000D_
facilities, but these are yet uneconomical for local testing facilities or point of care/testing devices. We recently_x000D_
demonstrated the working principle of a novel cost-effective, reliable and sensitive chemiresistive biosensor_x000D_
that is capable of rapidly detecting biomarkers within a minute. We propose to develop a multiplexed_x000D_
biosensing platform based on magnetic bio-inks that could be used in hospitals, reference labs and other similar_x000D_
healthcare institutions. This will be achieved by (1) developing magnetic bio-inks, (2) evaluating the_x000D_
performance biosensors printed with these inks, (3) comparing their performance with standard tests, and (4)_x000D_
developing multiplexing capabilities for the biosensor. We will follow this by scaling up the printing of_x000D_
diagnostic sensing strips and integrating them into devices that can be used to develop marketable products._x000D_
SQID will license and commercialize the technology, translating the research into a point of care/testing_x000D_
devices. The outcome of the proposed work promises significant commercial benefits to Canada through the_x000D_
creation of ~30 jobs and improved global presence in the healthcare industry. The project will also advance_x000D_
scientific understanding of chemiresistive biosensors., agreement title english : Development of cost-effective label-free protein biosensors using magnetic bio-inks, agreement title french : Development of cost-effective label-free protein biosensors using magnetic bio-inks, agreement number : CRDPJ, agreement value : 565000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2020-2021)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2020-2021)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada