Reference number : GC-2017-Q2-00042, amendment number : , agreement type : G, recipient legal name : Desgagné-Penix, Isabel (Université du Québec à Trois-Rivières), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for Universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : In living organisms, the oxidant/antioxidant unbalance plays a pivotal role in different pathophysiological_x000D_
conditions. General and specific antioxidants prevent the oxidative damage on biological targets and an intake_x000D_
of antioxidants is inversely associated with the risk to develop some pathologies.The Devonian Health Group is_x000D_
a late stage botanical pharmaceutical corporation with novel approaches to develop drugs and pharmaceuticals_x000D_
products including antioxidants. It is known that different antioxidants vary in their reducing power and_x000D_
mechanism of action, and the cooperation of different antioxidants, in a botanical extract for example, provides_x000D_
greater protection against oxidants than compound alone. Different chemical-based assays have been developed_x000D_
to determine antioxidant capacity. However, to study the potential antioxidant health-promoting effects of_x000D_
natural products, considering the complexity involved in their in vivo mechanisms of action, a single in vitro_x000D_
chemical assay is not enough to evaluate and compare their antioxidant properties. Therefore, the present_x000D_
project proposes to develop a Standardized Procedure to Assess Total Antioxidant Efficiency (SPATAE) that_x000D_
will be employed for screening antioxidant capacity, activity and effects of Devonian samples. In particular, we_x000D_
propose the combination of chemical-, biological-, and cellular-based assay to evaluate antioxidant efficiency_x000D_
at multiple biological levels. In the selection of the assays to include in the SPATAE, we aim to measure_x000D_
chemistry actually occuring in potential application using simple methods with defined endpoint and chemical_x000D_
mechanism also good within-run and between-day reproductibility. Without standardization, marketing of_x000D_
botanicals ans associated products becomes arbitrary and technological development of botanical_x000D_
pharmaceuticals and nutraceuticals is hindered., program purpose french : In living organisms, the oxidant/antioxidant unbalance plays a pivotal role in different pathophysiological_x000D_
conditions. General and specific antioxidants prevent the oxidative damage on biological targets and an intake_x000D_
of antioxidants is inversely associated with the risk to develop some pathologies.The Devonian Health Group is_x000D_
a late stage botanical pharmaceutical corporation with novel approaches to develop drugs and pharmaceuticals_x000D_
products including antioxidants. It is known that different antioxidants vary in their reducing power and_x000D_
mechanism of action, and the cooperation of different antioxidants, in a botanical extract for example, provides_x000D_
greater protection against oxidants than compound alone. Different chemical-based assays have been developed_x000D_
to determine antioxidant capacity. However, to study the potential antioxidant health-promoting effects of_x000D_
natural products, considering the complexity involved in their in vivo mechanisms of action, a single in vitro_x000D_
chemical assay is not enough to evaluate and compare their antioxidant properties. Therefore, the present_x000D_
project proposes to develop a Standardized Procedure to Assess Total Antioxidant Efficiency (SPATAE) that_x000D_
will be employed for screening antioxidant capacity, activity and effects of Devonian samples. In particular, we_x000D_
propose the combination of chemical-, biological-, and cellular-based assay to evaluate antioxidant efficiency_x000D_
at multiple biological levels. In the selection of the assays to include in the SPATAE, we aim to measure_x000D_
chemistry actually occuring in potential application using simple methods with defined endpoint and chemical_x000D_
mechanism also good within-run and between-day reproductibility. Without standardization, marketing of_x000D_
botanicals ans associated products becomes arbitrary and technological development of botanical_x000D_
pharmaceuticals and nutraceuticals is hindered., agreement title english : Development of a Standardized Procedure to Assess Total Antioxidant Efficiency of plant-based pharmaceuticals, agreement title french : Development of a Standardized Procedure to Assess Total Antioxidant Efficiency of plant-based pharmaceuticals, agreement number : EGP, agreement value : 25000.0, agreement start date : 2017-07-12, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada