Reference number : GC-2017-Q4-00280, amendment number : , agreement type : G, recipient legal name : Calmettes, Charles (Institut national de la recherche scientifique), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The grant proposal consists in establishing a method to locate and characterize the binding pockets of small_x000D_
molecule ligands (so called fragments) onto a protein target, at atomic resolution. NMX Research and_x000D_
Solutions Inc. is a research organization specialized in drug discovery and fragment screening using nuclear_x000D_
magnetic resonance spectroscopy. The company aims at developing novel methods for the screening of_x000D_
fragment and small molecule onto proteins. Such challenging project requires highly sensitive biophysical_x000D_
methods to obtain high-resolution structural information. Hence, understanding how low-affinity fragments_x000D_
bind to proteins remains a fundamental question and a technical challenge raised by NMX Research and_x000D_
Solutions. Dr. Calmettes, expert in protein structures and X-ray crystallography, will develop for NMX_x000D_
Research and Solutions an alternative method to identify and locate low-affinity fragment-binding sites on_x000D_
proteins using protein X-ray crystallography. Only a few groups in Canada have the expertise in preparing,_x000D_
crystallizing, and solving protein structures. This project is highly relevant for the Canadian industry and the_x000D_
advancement of knowledge in Canada; it is anticipated to open new avenues for the design of protein regulator_x000D_
for a variety of applications in biotechnology, bioscience and bio-industrial sectors in Canada., program purpose french : The grant proposal consists in establishing a method to locate and characterize the binding pockets of small_x000D_
molecule ligands (so called fragments) onto a protein target, at atomic resolution. NMX Research and_x000D_
Solutions Inc. is a research organization specialized in drug discovery and fragment screening using nuclear_x000D_
magnetic resonance spectroscopy. The company aims at developing novel methods for the screening of_x000D_
fragment and small molecule onto proteins. Such challenging project requires highly sensitive biophysical_x000D_
methods to obtain high-resolution structural information. Hence, understanding how low-affinity fragments_x000D_
bind to proteins remains a fundamental question and a technical challenge raised by NMX Research and_x000D_
Solutions. Dr. Calmettes, expert in protein structures and X-ray crystallography, will develop for NMX_x000D_
Research and Solutions an alternative method to identify and locate low-affinity fragment-binding sites on_x000D_
proteins using protein X-ray crystallography. Only a few groups in Canada have the expertise in preparing,_x000D_
crystallizing, and solving protein structures. This project is highly relevant for the Canadian industry and the_x000D_
advancement of knowledge in Canada; it is anticipated to open new avenues for the design of protein regulator_x000D_
for a variety of applications in biotechnology, bioscience and bio-industrial sectors in Canada., agreement title english : Method development for the identification and characterization of low-affinity ligand-binding sites on protein targets using X-ray crystallography, agreement title french : Method development for the identification and characterization of low-affinity ligand-binding sites on protein targets using X-ray crystallography, agreement number : EGP, agreement value : 24996.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada