Reference number : GC-2017-Q1-00239, amendment number : , agreement type : G, recipient legal name : Santerre, Paul (University of Toronto), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Collaborative Health Research Projects, program name french : Projets de recherche concertée sur la santé, program purpose english : Deformities of the face and skull (craniomaxillofacial, CMF) can result from high impact_x000D_
trauma, congenital malformations or tumours, which can lead to both functional disabilities_x000D_
and physical disfigurement. Much like a shattered vase, the fractured CMF skeleton requires_x000D_
alignment and stabilization of multiple pieces for successful reconstruction. In reconstructive_x000D_
surgery, generally using plates and screws, complications occur in up to half of all cases. The_x000D_
investigators have been working on the development of a composite material (Bone Tape)_x000D_
for skull surgical reconstruction. The concept is a strong duct tape like device that can_x000D_
adhere to bone and be used to reattach fractured pieces and hold them stable until they heal._x000D_
The properties of the composite offer a unique combination of strength, versatility and ease of_x000D_
use, with the flexibility of tape allowing wrapping and bonding to the complex bone contours_x000D_
found in the skeleton. The composite is also made of materials that will eventually (and_x000D_
safely) resorb over time after the fracture has healed, leaving only the mended bones behind._x000D_
In developing this concept with industry, the clinicians used some commercial dental bone_x000D_
cements that are not degradable and may generate residual particulate which the surgeons_x000D_
would prefer to be resorbed and eliminated. Hence, there is a need for the conception of a_x000D_
degradable adhesive polymer with appropriate physical, surface and biocompatibility_x000D_
properties that can interphase with composites. This project will ultimately provide the_x000D_
foundation for such a degradable organic polymer adhesive. Our clinical and scientific team is_x000D_
committed to translating the novel adhesive along with current composites into practice, in_x000D_
order to improve treatment and outcomes, with less complications and better lives for those_x000D_
recovering from serious CMF injuries and deformities., program purpose french : Deformities of the face and skull (craniomaxillofacial, CMF) can result from high impact_x000D_
trauma, congenital malformations or tumours, which can lead to both functional disabilities_x000D_
and physical disfigurement. Much like a shattered vase, the fractured CMF skeleton requires_x000D_
alignment and stabilization of multiple pieces for successful reconstruction. In reconstructive_x000D_
surgery, generally using plates and screws, complications occur in up to half of all cases. The_x000D_
investigators have been working on the development of a composite material (Bone Tape)_x000D_
for skull surgical reconstruction. The concept is a strong duct tape like device that can_x000D_
adhere to bone and be used to reattach fractured pieces and hold them stable until they heal._x000D_
The properties of the composite offer a unique combination of strength, versatility and ease of_x000D_
use, with the flexibility of tape allowing wrapping and bonding to the complex bone contours_x000D_
found in the skeleton. The composite is also made of materials that will eventually (and_x000D_
safely) resorb over time after the fracture has healed, leaving only the mended bones behind._x000D_
In developing this concept with industry, the clinicians used some commercial dental bone_x000D_
cements that are not degradable and may generate residual particulate which the surgeons_x000D_
would prefer to be resorbed and eliminated. Hence, there is a need for the conception of a_x000D_
degradable adhesive polymer with appropriate physical, surface and biocompatibility_x000D_
properties that can interphase with composites. This project will ultimately provide the_x000D_
foundation for such a degradable organic polymer adhesive. Our clinical and scientific team is_x000D_
committed to translating the novel adhesive along with current composites into practice, in_x000D_
order to improve treatment and outcomes, with less complications and better lives for those_x000D_
recovering from serious CMF injuries and deformities., agreement title english : Novel adhesive polymeric membranes for binding degradable composite materials to bone in craniomaxillofacial repair, agreement title french : Novel adhesive polymeric membranes for binding degradable composite materials to bone in craniomaxillofacial repair, agreement number : CHRPJ, agreement value : 260200.0, agreement start date : 2017-04-25, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada