Reference number : GC-2017-Q1-03033, amendment number : , agreement type : G, recipient legal name : McPherson, Peter (McGill University)|McPherson, Peter (Université McGill), recipient country : CA, recipient province : nan, recipient city : Quebec|Québec, recipient postal code : nan, program name english : Discovery Grants Program - Individual, program name french : Programme de subventions à la découverte - individuelles, program purpose english : The cell surface is defined by the plasma membrane, which separates the cell interior from the external world. The plasma membrane is studded with proteins that have multiple functions, for example allowing a cell to interact with other cells or to interact with essential cellular nutrients. These proteins are continuously brought into the cell in a process called endocytosis. Following internalization the proteins are delivered to a membrane compartment called endosomes that are a hub for protein sorting. From endosomes the proteins are either targeted for degradation as part of protein renewal or are recycled back to the plasma membrane for continued function. Through these activities endosomes control the levels and localization of a myriad of proteins and thus cell function. This project will examine the function of two specific proteins and how they interact to control key aspects of this fundamental cellular process. There are a large group of scientists, both in Canada and throughout the world that study how proteins are sorted in endosomes. Our work will enhance this field but perhaps more importantly, alterations in these pathways contribute to diseases that are of great concern to Canadians including neurodegenerative diseases and cancer. Our work will lay the foundation for further studies on these important topics., program purpose french : The cell surface is defined by the plasma membrane, which separates the cell interior from the external world. The plasma membrane is studded with proteins that have multiple functions, for example allowing a cell to interact with other cells or to interact with essential cellular nutrients. These proteins are continuously brought into the cell in a process called endocytosis. Following internalization the proteins are delivered to a membrane compartment called endosomes that are a hub for protein sorting. From endosomes the proteins are either targeted for degradation as part of protein renewal or are recycled back to the plasma membrane for continued function. Through these activities endosomes control the levels and localization of a myriad of proteins and thus cell function. This project will examine the function of two specific proteins and how they interact to control key aspects of this fundamental cellular process. There are a large group of scientists, both in Canada and throughout the world that study how proteins are sorted in endosomes. Our work will enhance this field but perhaps more importantly, alterations in these pathways contribute to diseases that are of great concern to Canadians including neurodegenerative diseases and cancer. Our work will lay the foundation for further studies on these important topics., agreement title english : Function of leucine-rich repeat kinase 2 (LRRK2) in endosomal trafficking, agreement title french : Function of leucine-rich repeat kinase 2 (LRRK2) in endosomal trafficking, agreement number : RGPIN, agreement value : 250000.0, agreement start date : 2017-05-10, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023), additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2022-2023), owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada