Reference number : GC-2017-Q4-01323, amendment number : , agreement type : G, recipient legal name : Murugkar, Sangeeta (Carleton University), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : Tornado Spectral Systems (Toronto, ON) was founded to invent and commercialize novel optical technologies_x000D_
for applications in the medical and industrial sectors. Their primary optical method is a technique called Raman_x000D_
spectroscopy, which uses a laser beam to perform non-destructive real-time measurements of chemical_x000D_
mixtures. Tornado's proprietary optical designs enable their Raman analyzers to be 10x to 30x more powerful_x000D_
than the current state of the art, so quantitative Raman measurements can be made more quickly, more_x000D_
sensitively, or more accurately than with conventional optical configurations. However, Tornado's technology_x000D_
is only one part of the solution in the case of analysis of blood samples. Due to its chemical and cellular_x000D_
structure, blood absorbs much of the laser energy rather than scattering the wavelength-shifted Raman photons_x000D_
which provide chemical information. This fact has two main implications: (1) the Raman signal from blood_x000D_
will be weaker than for most other types of chemical samples, and (2) the incident laser power must be kept_x000D_
low to avoid heating and damaging the blood sample, and lower laser power produces even weaker Raman_x000D_
signal. Since blood analysis is often looking for very subtle changes in the Raman spectrum, both of these_x000D_
factors can severely limit the applicability of Raman techniques. In collaboration with Tornado Spectral_x000D_
Systems, the current proposal aims to overcome these limitations and focuses on the development of a novel_x000D_
flow cell module for the translation of Raman spectroscopy to blood analysis. The duration of the project will_x000D_
be six months and this work will serve as the foundation for future grant applications., program purpose french : Tornado Spectral Systems (Toronto, ON) was founded to invent and commercialize novel optical technologies_x000D_
for applications in the medical and industrial sectors. Their primary optical method is a technique called Raman_x000D_
spectroscopy, which uses a laser beam to perform non-destructive real-time measurements of chemical_x000D_
mixtures. Tornado's proprietary optical designs enable their Raman analyzers to be 10x to 30x more powerful_x000D_
than the current state of the art, so quantitative Raman measurements can be made more quickly, more_x000D_
sensitively, or more accurately than with conventional optical configurations. However, Tornado's technology_x000D_
is only one part of the solution in the case of analysis of blood samples. Due to its chemical and cellular_x000D_
structure, blood absorbs much of the laser energy rather than scattering the wavelength-shifted Raman photons_x000D_
which provide chemical information. This fact has two main implications: (1) the Raman signal from blood_x000D_
will be weaker than for most other types of chemical samples, and (2) the incident laser power must be kept_x000D_
low to avoid heating and damaging the blood sample, and lower laser power produces even weaker Raman_x000D_
signal. Since blood analysis is often looking for very subtle changes in the Raman spectrum, both of these_x000D_
factors can severely limit the applicability of Raman techniques. In collaboration with Tornado Spectral_x000D_
Systems, the current proposal aims to overcome these limitations and focuses on the development of a novel_x000D_
flow cell module for the translation of Raman spectroscopy to blood analysis. The duration of the project will_x000D_
be six months and this work will serve as the foundation for future grant applications., agreement title english : Development of a Raman micro-spectroscopy flow cell module, agreement title french : Development of a Raman micro-spectroscopy flow cell module, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada