Reference number : GC-2017-Q4-01385, amendment number : , agreement type : G, recipient legal name : Organ, Michael (University of Ottawa)|Organ, Michael (Université d’Ottawa), recipient country : CA, recipient province : nan, recipient city : Ontario, recipient postal code : nan, program name english : Engage Grants for universities, program name french : Subventions d'engagement partenarial pour les universités, program purpose english : The project will involve the design, construction and integration of reactor modules which are capable of_x000D_
receiving fluids from multiple reagent reservoirs for batch or flow synthetic chemistry experiments. Current_x000D_
conventional manufacturing of fine chemicals uses large reaction vessels in which all the reagents are added_x000D_
and the reaction stirred and heated or cooled as necessary to drive the transformations to completion. For a_x000D_
variety of reasons, such reactions can sometimes not reach preset specifications and this is referred to as a batch_x000D_
failure. In the pharmaceutical sector, this can have catastrophic consequences for patients heavily reliant on_x000D_
constant supply of the active pharmaceutical ingredient (API) that makes up their drugs. As a consequence, the_x000D_
pharmaceutical sector targets the production of 2.5X the actual annual requirement of API, just to ensure a_x000D_
constant supply. This material is biologically active and if not used, must then be carefully decomposed, which_x000D_
is not only an unnecessary cost but raises health and environmental concerns. Flow chemistry is seen as the_x000D_
future of the fine chemical manufacturing sector as the material is made constantly, but on a much smaller_x000D_
scale. So, it is safer, consumes less energy, and only produces the amount of API material that is required. Most_x000D_
often, reactions have been optimized in batch reactors, and then are modified to suit production in flow. There_x000D_
exists no platform to readily move between these two manufacturing technologies. This proposal seeks to fill_x000D_
this gap with new robotic reactor technology that will allow for the ready movement back and forth between_x000D_
process optimization for batch reactions and for flow applications. This will be disruptive technology and there_x000D_
are presently zero products in this marketspace., program purpose french : The project will involve the design, construction and integration of reactor modules which are capable of_x000D_
receiving fluids from multiple reagent reservoirs for batch or flow synthetic chemistry experiments. Current_x000D_
conventional manufacturing of fine chemicals uses large reaction vessels in which all the reagents are added_x000D_
and the reaction stirred and heated or cooled as necessary to drive the transformations to completion. For a_x000D_
variety of reasons, such reactions can sometimes not reach preset specifications and this is referred to as a batch_x000D_
failure. In the pharmaceutical sector, this can have catastrophic consequences for patients heavily reliant on_x000D_
constant supply of the active pharmaceutical ingredient (API) that makes up their drugs. As a consequence, the_x000D_
pharmaceutical sector targets the production of 2.5X the actual annual requirement of API, just to ensure a_x000D_
constant supply. This material is biologically active and if not used, must then be carefully decomposed, which_x000D_
is not only an unnecessary cost but raises health and environmental concerns. Flow chemistry is seen as the_x000D_
future of the fine chemical manufacturing sector as the material is made constantly, but on a much smaller_x000D_
scale. So, it is safer, consumes less energy, and only produces the amount of API material that is required. Most_x000D_
often, reactions have been optimized in batch reactors, and then are modified to suit production in flow. There_x000D_
exists no platform to readily move between these two manufacturing technologies. This proposal seeks to fill_x000D_
this gap with new robotic reactor technology that will allow for the ready movement back and forth between_x000D_
process optimization for batch reactions and for flow applications. This will be disruptive technology and there_x000D_
are presently zero products in this marketspace., agreement title english : A single liquid-handling robotic platform for batch and flow chemistry applications, agreement title french : A single liquid-handling robotic platform for batch and flow chemistry applications, agreement number : EGP, agreement value : 25000.0, agreement start date : 2018-03-07, agreement end date : nan, description english : nan, description french : nan, expected results english : nan, expected results french : nan, additional information english : Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019)., additional information french : Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019)., owner organization : nserc-crsng, owner organization title : Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada