parvathy mills limited or parvathi mills limited is a textile manufacturing company owned by the national textile corporation ( ntc ) situated in kollam city , india .

the company was founded in 1884 .

the land was owned by the kerala state textile corporation at that time , and later was handed over to the ntc .

the company has 120 employees , six of which are ntc staffers and 17 are casual workers .

the plant has been shut down since 2008 pending modernisation .

parvathy mills limited

the tharisappalli copper plates ( 849 ad ) are a copper - plate grant issued by the king of . . . indian rare earths limited ( irel ) · kerala minerals and metals ltd . ( kmml ) . . . parvathy mills limited · united electrical industries limited ( unilec ) .
the ntc planned to privatize parvathy mills in 2005 . the plant was added by the board for industrial and financial reconstruction who had listed it for revival in 2002 . the plan was dropped after protests by the parvathy mills workers union . [ 5 ]
shri uma parvathy textile mills private limited is an unlisted private company incorporated on 19 february , 2007 . the registered office of the company is at 51 , rajaji street lakshmipuram post theni district chennai , tamil nadu .
ms . lakshmi said that since there was no production at parvathy mills , the issue of wage revision would have to be taken by the union cabinet . she said she would bring the issue to the attention of the cabinet . casual workers of parvathy mills were being paid a wages of only rs . 135 a day .
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a turning point in the trade union history of coimbatore was when 15 mills including kaleeswara mills , pankaja mills and cambodia mills were declared sick units in 1967 . the workers protested the mismanagement of the mills that led to their decline . over 5 , 000 workers were imprisoned and the strike led to the formation of the tamil nadu textile corporation , which took over the mills .
the movement in coimbatore was spearheaded by parvathy krishnan and other leaders , which laid the foundation for the central government to draft a bill in 1974 and form the national textile corporation ,
says arumugam .
parvathi mills ltd was registered at registrar of companies ernakulam on 21 january , 1957 and is categorised as company limited by shares and an non - govt company . parvathi mills ltd ' s corporate identification number ( cin ) is u24304kl1957plc001728 and registeration number is 001728 .
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measures to revive the national textile corporation ( ntc ) - owned parvathy mills in kollam city got a fresh boost with union minister of state for textiles panabaka lakshmi visiting the company on friday .
president of the citu - affiliated parvathy mills workers union n . padmalochanan said the litigation issue coming in the way of the company’s revival was only a lame excuse given by the union minister .
digvijay textile mills compound , dr . babasaheb ambedkar road , kalachowki , mumbai - 400033 .
kollam : the pro - utuc parvathy mills workers union has urged the central government to drop moves aimed at privatising the national textiles corporation ( ntc ) managed parvathy mills at kollam . at a press conference here recently , union president n . k . premachandran , mp , and general secretary philip k . thomas said that the board for industrial and financial reconstruction had , in 2002 , included mill in the revival list .
parvathi mills ltd is involved in activity and currently company is in not available for efiling status .
and subsequent fatigue analysis to calculate the life expended on the life - limited components . to assess the potential benefit of
in transcranial magnetic stimulation ( tms ) , which is currently very limited in commercial devices . approach we present a third generation
president of the utuc - affiliated quilon district textile workers union n . k . premachandran brought to the attention of the minister that the wage revision of other ntc mills should be made applicable to the workers of parvathy mills too . he said that the workers were still given wages based on a revision that came into effect 15 years ago .
in transcranial magnetic stimulation ( tms ) , which is currently very limited in commercial devices . approach . we present a third generation
chairman of the people’s initiative kollamb . a . rajakrishnan inaugurating a dharna in front of the parvathy mills complex on wednesday demanding that the mill’s land be made available for a medical college hospital in kollam . — photo : c . suresh kumar
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the gradual closure of the mills in the 1980s adversely impacted the unions . the classification and separation of the mills into four categories based on the spindle capacity in 1987 further affected the sector as more and more private mills reduced their spindle capacity and started to shift units to rural areas , where cheap labour could be employed on temporary contracts .
in fact , the government was willing to spend any amount for the revival of parvathy mills . a technical feasibility study would be undertaken for the purpose . the ntc had prepared a standard model for the revival of the mills under its management . she said that steps would be taken to disburse the salary of parvathy mills workers promptly every month and the pending salary of the month of may 2012 would be given in a week’s time . she said she was visiting the company at the invitation of n . peethambara kurup , mp . leaders of various trade unions submitted memoranda to the minister for the early revival of the company .
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the list included four other mills in the state and the revival programme was suggested based on a detailed study by the south indian textiles research organisation . according to the study , parvathy mills was financially and technologically viable . the ntc had reached an agreement with the financial institutions and the trade unions to revive the mill and an agreement was signed in march 2002 , mr . premachandran said .
the 16 acres owned by parvathi mills in the heart of the city which is under consideration has been tangled in administrative delays .
theni guru krishna textile mills private limited ' s annual general meeting ( agm ) was last held on 2015 - 09 - 23 . as per records from ministry of corporate affairs ( mca ) , this company ' s balance sheet was last filed on 2015 - 03 - 31 .
the characteristics of transcranial magnetic stimulation ( tms ) pulses influence the physiological effect of tms . however , available tms devices allow very limited adjustment of the pulse
the parvathy mills was closed down on november 26 , 2008 , for facilitating its modernisation programme . but no modernisation programme had taken place and production had not resumed . payment of salary too was irregular . the company has 97 permanent staff and six ntc staff apart from the 17 casual workers .
digvijay textile mills cloth shop , shop no . 17 to 21 , dr . babasaheb ambedkar road , kalachowki , mumbai - 400033 .
digvijay textile mills cloth shop , shop no . 41 & 42 , dr . babasaheb ambedkar road , kalachowki , mumbai - 400033 .
representatives from kollam along with organizations staged a dharna and march in february 2014 to try to obtain the parvathy mill land as the site for a government medical college .
the union government was committed to reviving all the textile mills managed by the ntc . measures were also being taken to ensure job security to the workers of these mills . the government would take all possible steps to develop the textile sector of the country , she said .
parvathi mills ltd registered address on file is m c 94hospital road vadak kumbhagom quilon kozhikode kl 000000 in , kozhikode - 000000 , kerala , india .
along with many other mills in mumbai , coimbatore , ahmedabad , aurangabad , akola , nanded , naini , jaipur and udaipur , parvathy mill was slated for redevelopment and modernisation in 2007 [ 6 ] and 2012 . [ 7 ] to date these improvements have not taken place , and mill has been closed since 2008 . [ 8 ] [ 2 ]
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monitoring and assess the potential benefits of extending the retirement intervals of life - limited components , thus reducing the operator ' s maintenance and replacement costs . both techniques involve indirect determination of loads using measured flight
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after interacting with trade union leaders attached to the company , ms . lakshmi said the union government was prepared to revive parvathy mills . “even funds are not a hurdle to the revival of the company , ” she said . at the same time a litigation pending in the high court pertaining to the modernisation of the company was hampering the programme of the government to revive the company . once the litigation was over , the company would be revived , she said .
the recent nurses’ strike in a city hospital was almost a throwback to the past . however , that the strike was limited to one hospital and that major trade unions were not involved in it itself revealed how much the city’s political culture had changed .
parvathi mills ltd ' s annual general meeting ( agm ) was last held on n / a and as per records from ministry of corporate affairs ( mca ) , its balance sheet was last filed on n / a .
working class politics emerged in coimbatore in 1930s and ’40s , when the workers of textile mills in the city began to demand better wages and working conditions . the first trade union in the city , coimbatore mill workers union , was formed in 1937 .
those days , special overseers armed with whips were posted in mills to ensure that employees work for at least 16 hours daily without rest ,
says m arumugam , cpi mla from valparai .
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parvathi mills ltd ' s corporate identification number is ( cin ) u24304kl1957plc001728 and its registration number is 1728 . its email address is and its registered address is m c 94hospital road vadak kumbhagom quilon kozhikode kl 000000 in , - , .
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is a private limited company incorporated on 20 / 01 / 2005 and is 13 years 5 months 19 days old . it is classified as indian non - government company and is registered at roc - chennai . its authorized share capital is rs . 30000000 and its paid up capital is rs . 24900000 .
members of the people’s initiative kollam ( pik ) staged a dharna in front of the national textile corporation ( ntc ) - owned parvathi mills complex , near chinnakada , in the city on wednesday demanding that the land housing the mill should be used for productive purposes .
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- ( 1 . ) the petitioner was a worker of parvathy mills , kollam . he is aggrieved that the labour court , kollam upheld the order of the management passed in disciplinary proceedings and confirmed the dismissal of the petitioner along with 9 others in exhibit p6 award . ( 2 . ) the charge against the petitioner was that in the course of an illegal strike he , along with others tried to push a big godrej steel almirah on to an officer of the mills where he was working and that if no one had blocked the almirah it would have fallen on the officer with fatal results . it was also alleged that the petitioner at the time was in drunken condition . ( 3 . ) after due enquiry , the enquiry officer confirmed the fact that as alleged in the charge , the said incident did took place and it was thereupon that the management imposed punishment of dismissal from service which ultimately resulted in the impugned order . ;
jan 21 , 2013 . . . inside mining jan 2013 edition | is a digital publishing platform . . . prestigious projects 2012 / 2013 • kolomela • tharisa • cullinan . . . . . . for this , adaptations to the plant would include the incorporation of mills , rolls . . .
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coimbatore used to be an active sphere for workers movements and protests . a few decades back even the normal kitchen talk in households would be about the textile mills and the problems of the workers . there was a high level of awareness in the society especially among the middle class ,
said cr bijoy , city - based social activist .
naturally , mill workers formed the fulcrum of trade unions in the city followed by employees of garment units and mechanical manufacturing units that were booming sectors . the city’s trade union leaders and activists like jeevanandam , k n sinnayan , n k krishnan , parvathy krishnan , a subramaniam , u k vellingiri and p s chinnadurai were nationally known . intuc , aituc and hms dominated unions until the dmk came into the picture in the 1960s .
parvathi mills ltd is a public incorporated on 21 january 1957 . it is classified as non - govt company and is registered at registrar of companies , ernakulam . its authorized share capital is rs . 2 , 500 , 000 and its paid up capital is rs . 1 , 100 , 000 . it is inolved in manufacture of man - made fibers [ this class includes manufacture of artificial or synthetic filament and non - filament fibers . ]
this article describes new developments in an incremental , robot - based sheet metal forming process ( roboforming ) for the production of sheet metal components for small lot sizes and prototypes . the dieless kinematic - based generation of the shape is implemented by means of two industrial robots , which are interconnected to a cooperating robot system . compared to other incremental sheet forming ( isf ) machines , this system offers high geometrical design flexibility without the need of any part - dependent tools . however , the industrial application of isf is still limited by certain constraints , e . g . the low geometrical accuracy . responding to these constraints , the authors introduce a new architectural setup extending the current one by a superordinate process
however , the ntc management failed to implement its provisions , mr . premachandran alleged .
instead , the ntc began moves to privatise the mill and invited tenders for the purpose .
copyright � 2005 , the hindu . republication or redissemination of the contents of this screen are expressly prohibited without the written consent of the hindu
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the district administration is also eyeing the land near ashramam guest house for the project despite protests from the people . picture for representational purpose
kollam : the continuing delay in identifying land has been keeping the ambitious medical college project in the district in limbo .
the district administration is also eyeing the land near ashramam guest house for the project despite protests from the people .
a high - level meeting attended by health and labour ministers had directed the district collector to submit a report regarding locating 10 acres on the south part of ashramam guest house .
however , the public demand is that the college be set up on the parvathi mill land which is much closer to the district hospital and the government victoria hospital .
“the land owned by parvathi mill is definitely the spot to be considered to set up the medical college which is a long - pending dream of the people of kollam , ” said p . k . gurudasan , mla .
meanwhile , parvathi mill is battling litigation on the abandoned modernisation moves allegedly at the behest of “vested interests” with an eye on the land .
the district administration also has land at mukhathala , kundara and mundakkal under consideration .
the land of parvathi mill currently registered with national textile corporation was donated by erstwhile king of travancore in 1884 to start ad cotton mill . the land was with kerala state textile corporation in 1972 and was taken over by ntc in 1974 .
fresh hopes for workers : n . peethambara kurup , mp , handing over a memorandum to union minister of state for textiles panabaka lakshmi in kollam on friday . —photo : c . suresh kumar
he said the private company that went in litigation had no locus standi in the case because no contract was awarded to that company . the government was not following up the litigation in the desired manner , he alleged .
inaugurating the dharna , pik chairman b . a . rajakrishnan said that with the proposal for starting a medical college hospital ( mch ) attached to the district hospital gaining momentum , the 25 acres of land where the mill was located would be the right property to house the medical college .
he said the mill complex was only about 100 metres from the district hospital complex .
even after lying closed for many years , there was no move from the side of the ntc to revive the mill . the whole machinery and buildings in the complex were in ruins .
the pik activists called for immediate rehabilitation of the remaining employees of the mill so as to make the complex available for the people of kollam city for accommodating the much - needed mch .
the dharna was led by pik leaders ferdinand kayavil , m . a . salam , sivaramakrishna pillai , k . p . ramachandran , t . reghunath , rajashekaran pillai , jane ancil , and d . syamantha bhardan .
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manufacture of man - made fibers [ this class includes manufacture of artificial or synthetic filament and non - filament fibers . ]
graphical report containing historical financial performance . click here to view financial report of infosys ltd .
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75 , m . c . road , madras75 , m . c . road , madras 75 , m . c . road , madras 75 , m . c . road , madras tn 000000 in
no . c - 603 , shivalaya buildingc - in - c road chennai - 600 008 . c - in - c road , chennai - 600 008 . c - in - c road , chennai - 600 008 . chennai tn 000000 in
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his highness visakham thirunal rama varma , the then maharaja of travancore took the initiative to start a spinning mill in quilon city ( now known as kollam ) which was then business capital of travancore along the malabar coast . he donated the land to start the ad cotton mill in 1884 . the land was handed over to national textile corporation in 1974 . [ 4 ]
valued at more than rs . 4 billion ( us $ 64 million ) as per the market value of 2014 .
, administrative delays in deciding on a site and obtaining land continue to delay the start of construction of the new college .
this page was last edited on 5 may 2018 , at 02 : 12 .
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the total paid - up capital is inr 0 . 00 . the company has no reported secured loans .
details of its last annual general meeting are not available . the company is yet to submit its first full - year financial statements to the registrar .
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in september 2012 , tharisa minerals ( pty ) ltd . had nearly completed its new . . . . . ore from mapochs was consumed in highveld ' s steel mill at . witbank ; the . . .
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registration number of the company is 55188 . u17111tn2005ptc055188 is the corporate identification number ( cin ) of this company . its registered address is 207 - b , theni district , tamil nadu , 625531 .
the company is involved in blended cotton yarn , spinning ( not charkha ) , cotton yarn , spinning ( not charkha ) , preparation of cotton fiber including blended cotton , spinning of cotton fiber including blended cotton , yarn of blended cotton , spinning ( not charkha ) , yarn of cotton , spinning ( not charkha ) .
directors of this company are thathaya krishnasamy srinivasan , rajasekar subbiah , thathaya krishnasamy ponraj and ramasamy thathaiah krishnasamy .
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coimbatore : their memory is a bit hazy as they go back in time to reflect on the days when coimbatore was synonymous with workers’ movements and struggles for securing the rights of the men and women , who made the spindles spin and earn the city its title of the manchester of south india .
disappointment is evident in the tone and body language of the trade union leaders of the past as they admit to the decline of the workers movements over the years . they concede that the working class itself has undergone drastic transformation post - 1990s , and that the trade union movements have either reached a point of stagnation or have slowly dissolved in a market - dominated system that offers minimum space for dissent or activism from the workers .
very few leaders from those days are alive today . we all shared a common dream of strengthening the working class and their basic rights , ’ says 72 - year - old uk vellingiri , cpm leader and a former mla .
vellingiri recollects the five - and - half month - long strike at the lakshmi machine works unit in coimbatore when 400 workers were imprisoned for 22 days in 1977 . the agitation was triggered when the management decided to terminate two permanent employees .
mgr intervened to resolve the crisis . his labour minister s raghavanandam personally asked us to withdraw the strike . we carried on till the workers were reinstated ,
says vellingiri .
the sumangali scheme and the deployment of temporary workers adversely affected the sector as managements could easily keep them under check and even gag them if they dared to raise their voice ,
says a subramaniam , four - time president , hind mazdoor sabha .
the 1990s saw a major shift in the economy that led to the growth of the service sector . industrial employment declined and so did the industrial working class . the entry of new forms of contractual employment demolished old notions of working class solidarity and consciousness . the new corporate culture hardly offered space for socialisation centred on trade unions and the lower orders of labour were increasingly constituted of migrant workers drawn from even northern states , who were put up in camps .
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ghosh , soumyadip ; hosking , jonathan r . ; natarajan , ramesh ; subramaniam , shivaram ; zhang , xiaoxuan
in an emerging smart energy grid using time - dependent dynamic pricing incentives . the daily load is modeled as time - shifted , but cost - differentiated and substitutable , copies of the continuously - consumed electricity resource , and a consumer - choice prediction model is constructed to forecast the corresponding intra - day shares of total daily load according to this model . this is embedded within an optimization framework for managing the daily electricity
. a series of transformations are employed , including the reformulation - linearization technique ( rlt ) to obtain a mixed - integer programming ( mip ) model representation of the resulting nonlinear optimization problem . in addition , various regulatory and pricing constraints are incorporated in conjunction with the specified profit and capacity utilization objectives .
technology , identify barriers to technology adoption , and explore firm owner perception of risk . industry use of the following technologies was described : wet methods , respiratory protection , pole sanders , ventilated sanders , and low - dust joint compound . a survey instrument composed of both likert - type scaled items and open - ended items was developed and administered by telephone to the census population of the owners of member firms of trade associations : finishing contractors association and association of the wall and ceiling industries . of 857 firms , 264 interviews were completed . along with descriptive statistics , results were analyzed to examine effects of firm size and union affiliation on responses . responses to open - ended items were analyzed using content analysis procedures . firm owners rated the risk of dust to productivity and customer satisfaction as low - moderate . half rated the dust as having some impact on worker health , with higher impacts indicated by owners of small firms . among the available
technologies , respiratory protection was used most frequently . several barriers to implementation of the more effective
functions of each of 50 20 - sec epochs . the analysis of each epoch yielded five distinct plotted
devices allow the left hand to generate vertical translation , direct lift , or pitch - pointing commands that are decoupled from those of the right hand . attention is given to the
patterns obtained for decoupled normal flight , air - to - air gun engagement decoupled maneuvering , and decoupled air - to - surface bombing run maneuvering .
automata are an extension of finite stata automata , with some additional features ( e . g .
automata are expressive enough to model security requirements of real - world applications ; at the same time , they are simple enough to be statically amenable , e . g . they can be model - checked against abstractions of program
dempsey , paula j . ; handschuh , robert f . ; delgado , irebert r .
monitoring system data when detecting rotorcraft transmission health . six gear sets were tested in the nasa glenn spiral bevel gear fatigue rig . damage was initiated and progressed on the gear and pinion teeth . damage progression was measured by debris generation and documented with inspection photos at varying torque values . a contact fatigue analysis was applied to the gear design indicating the effect temperature , load and reliability had on gear life . results of this study illustrated the benefits of combining hums data and actual
dempsey , paula j . ; handschuh , robert f . ; delgado , irebert , r .
monitoring system data when detecting rotorcraft transmission health . three gear sets were tested in the nasa glenn spiral bevel gear fatigue rig . damage was initiated and progressed on the gear and pinion teeth . damage progression was measured by debris generation and documented with inspection photos at varying torque values . a contact fatigue analysis was applied to the gear design indicating the effect temperature , load and reliability had on gear life . results of this study illustrated the benefits of combining hums data and actual
identification problem of general discrete time , nonlinear , multiple input / multiple output dynamic systems with gaussian white distributed measurement errors is considered . the knowledge of the system parameterization was assumed to be known . concepts of local
vari - ant of the general lotka - volterra model for interspecific competition . the variant described the emergence of one subpopulation from another as a . . . distribut ion unlimited . i & . arstract ( maumunw2o1 a unified arioroximation framework for
estimation in general linear poe models has been completed . . . unified approximation framework for
estimation in general linear pde models . this framework has provided the theoretical basis for a number of
( acc ) or collision warning systems , is increasingly becoming a part of everyday driving . these systems are not perfect though , and the driver has to be prepared to reclaim
in situations very similar to those the system easily handles by itself . this paper uses a questionnaire answered by 130 acc users to discuss future research needs in the area of driver assistance systems . results show that the longer drivers use their systems , the more aware of its limitations they become . moreover , the drivers report that acc forces them to take
. copyright â© 2011 elsevier ltd and the ergonomics society . all rights reserved .
hospital - acquired infection often occurs because of lapses in accepted standards of practice on the part of health care personnel . the aim of this study is to attract attention on poor hospital infection
practice in venepuncture and use of tourniquets and emphasize the importance of hand hygiene . overall compliance with hygiene during
measures was evaluated . according to the questionnaire , only 26 . 9 % of respondents always washed their hands both before and after venepuncture . in the second step of the study , based on direct observation , hands were washed both before and after venepuncture on only 41 ( 45 . 1 % ) occasions . failure to remove gloves after patient contact was observed on 23 . 1 % occasions . our survey reveals poor infection
shin , jong - yeob ; wu , n . eva ; belcastro , christine ; bushnell , dennis m . ( technical monitor )
effectiveness factors . the estimates are provided on - line by a two - stage kalman estimator . the inherent conservatism of the lpv design is reducing through the use of a scaling factor on the uncertainty block that represents the estimation errors of the effectiveness factors . simulations of the
system with the on - line estimator show that a superior fault - tolerance can be achieved .
introduction over the last two decades , many studies have shown better long - term patency rates and survival in patients undergoing coronary artery bypass grafting ( cabg ) with left internal mammary artery ( lima ) to the left anterior descending artery ( lad ) . world - wide , lima is accepted as the âgold standardâ for surgical revascularisation and its
has been steadily increasing . patients and methods between april 1997 and september 2001 , a total of 4406 consecutive patients underwent coronary artery bypass grafting with revascularisation to the left anterior descending artery . results of the study group , 4047 ( 91 . 8 % ) patients received lima to lad , leaving 359 ( 8 . 2 % ) who did not . six sub - groups of patients in whom lima
was significantly less were the elderly ( > 70 years of age ) , females , diabetics , patients having emergency cabg , poor left ventricular ( lv ) function ( ejection fraction [ ef ] < 30 % ) and patients with respiratory disease . conclusions although the current focus in the uk is on mortality rates , we believe that it will not be long before this will also include the incidence of major morbidity after cabg such as stroke , myocardial infarction ( mi ) , renal failure and sternal wound problems . we also believe that we should now consider lima
( velocity of throw ) on changes in throwing pattern . sixty adult female throwers ( ages 20 - 26 years ) were randomly placed into one of four practice conditions : ( a ) scale up on velocity with no instruction , ( b ) maintain constant velocity with noâ¦
that minimizes a finite time quadratic performance index . the numerical scheme is particularly robust when it is applied to the
law synthesis for systems with densely packed modes and where there is a high likelihood of encountering degeneracies in the closed loop eigensystem . this approach through the use of a accurate pade series approximation does not require the closed loop system matrix to be diagonalizable . the algorithm has been included in a
can prevent tire force saturation near tire force limit during cornering . simulations and test runs by the custom made four wheel drive in - wheel motor electric vehicle show that higher driving stability performance compared to the performance of the same vehicle without
there are reports suggesting that sensitivity to and tolerance of both clinical and experimental pain differ among ethnic groups . we examined self - rated pain score and morphine
in 1034 women who underwent elective lower cesarian section ( lscs ) for their deliveries . data on pain scores and amount of total morphine use according to patient -
analgesia were collected every 4 hours . overall , lowest pain scores were recorded 12 hours after surgery and highest at 24 hours . morphine consumption was highest within the first 4 hours and lowest between 12 and 16 hours . there were statistically significant ethnic group differences in pain scores ( p = 1 . 7 x 10 ( - 7 ) ) and morphine
( p = 2 . 8 x 10 ( - 15 ) ) between ethnic groups , with indians having the highest mean pain score and using the highest amount of morphine . the ethnic differences in pain score and morphine self - administration persisted after
for age , body mass index , and duration of operation . our findings of highly significant ethnic group difference in self - reported pain level and the amount of analgesia self - administered may have implications on optimal management of acute postoperative pain . inadequate management of pain after cesarian deliveries might affect the emotional well - being and physical recovery of patients and affect mother - child bonding .
group and three treatment groups . each group was divided into five replicates as subgroups , comprising 12 quails each . dried brewing yeast ( saccharomyces cerevisiae ) was used at the levels of 1 . 5 % , 3 . 0 % and 4 . 5 % in the diets of the first , second and third treatment groups , respectively . soyabean meal was replaced with dried brewing yeast . the diets were formulated to be isocaloric and isonitrogenous . the experimental period lasted 18 weeks . dietary treatments did not significantly affect body weight , daily feed intake , daily protein intake , egg production , egg weight , feed efficiency , mortality , egg shell thickness , egg albumen index , egg yolk index , egg haugh unit , the percentages of egg shell , albumen and yolk , excreta moisture and small intestinal ph . inclusion of 3 % and 4 . 5 % dried brewing yeast in diets reduced egg yolk cholesterol concentration as mg per yolk and mg per g yolk ( p < 0 . 01 ) . blood serum cholesterol of groups fed diets with dried brewing yeast was significantly lower ( p < 0 . 01 ) than that of the
group . feeding diets containing 3 . 0 % and 4 . 5 % dried brewing yeast resulted in significant increases ( p < 0 . 01 ) in blood serum levels of total protein , alanine aminotransferase at the end of the experiment . blood serum levels of uric acid , triglyceride , aspartate aminotransferase and alkaline phosphatase were not affected by dietary dried brewing yeast . it is concluded that dried brewing yeast can be used up to 4 . 5 % in the diets of laying quails without adverse effects on the measured
smart home has gained widespread attention due to its flexible integration into everyday life . pervasive sensing technologies are used to recognize and track the activities that people perform during the day , and to allow communication and cooperation of physical objects . usually , the available infrastructures and applications leveraging these smart environments have a critical impact on the overall cost of the smart home construction , require to be preferably installed during the home construction and are still not user - centric . in this paper , we propose a low cost , easy to install , user - friendly , dynamic and flexible infrastructure able to perform runtime resources management by decoupling the different levels of
. this allows us to simplify the continuous updating and improvement , to reduce the maintenance effort and to improve residents’ living and security . a first validation of the proposed infrastructure on a case study is also presented .
systems ( ics ) . the authors propose using the elements of the fog - computing concept to enhance the reliability function . the key idea of fog - computing is to shift computations to the fog - layer of the network , and thus to decrease the workload of the communication environment and data processing components . as for ics , workload also can be distributed among sensors , actuators and network infrastructure facilities near the sources of data . the authors simulated typical workload distribution situations for the âtraditionalâ ics architecture and for the one with fogcomputing concept elements
. the paper contains some models , selected simulation results and conclusion about the prospects of the fog - computing as a means to enhance ics reliability .
castoe , t . a . ; gu , w . ; de koning , a . p . j . ; daza , j . m . ; jiang , z . j . ; parkinson , c . l . ; pollock , d . d .
gradients of nucleotide bias and substitution rates occur in vertebrate mitochondrial genomes due to the asymmetric nature of the replication process . the evolution of these gradients has previously been studied in detail in primates , but not in other vertebrate groups . from the primate study , the strengths of these gradients are known to evolve in ways that can substantially alter the substitution process , but it is unclear how rapidly they evolve over evolutionary time or how different they may be in different lineages or groups of vertebrates . given the importance of mitochondrial genomes in phylogenetics and molecular evolutionary research , a better understanding of how asymmetric mitochondrial substitution gradients evolve would contribute key insights into how this gradient evolution may mislead evolutionary inferences , and how it may also be incorporated into new evolutionary models . most snake mitochondrial genomes have an additional interesting feature , 2 nearly identical
regions , which vary among different species in the extent that they are used as origins of replication . given the expanded sampling of complete snake genomes currently available , together with 2 additional snakes sequenced in this study , we reexamined gradient strength and cr
in alethinophidian snakes as well as several lizards that possess dual crs . our results suggest that nucleotide substitution gradients ( and corresponding nucleotide bias ) and cr
is highly labile over the â¼200 m . y . of squamate evolution , and demonstrates greater overall variability than previously shown in primates . the evidence for the existence of such gradients , and their ability to evolve rapidly and converge among unrelated species suggests that gradient dynamics could easily mislead phylogenetic and molecular evolutionary inferences , and argues strongly that these dynamics should be incorporated into phylogenetic models . pmid : 20215734


spotlight innovation inc. ( otcqb : stlt ) is a united states pharmaceutical holding company that identifies and acquires early stage pharmaceutical companies that are developing unique intellectual property often in academic settings .

the company currently maintains two subsidiaries : memcine pharmaceuticals , inc. and celtic biotech iowa , inc . spotlight innovation inc. is based in west des moines , iowa and is publicly traded on the otcqb marketplace under the stock ticker symbol , stlt .

spotlight innovation

spotlight innovation subsidiary celtic biotech iowa receives approval to commence phase i part 2 clinical trial of crotoxin : : spotlight innovation inc . ( stlt )
spotlight innovation subsidiary celtic biotech iowa granted patent by the u . s . patent and trademark office : : spotlight innovation inc . ( stlt )
spotlight innovation subsidiary celtic biotech iowa , inc . completes merger with celtic biotech ltd .
spotlight innovation inc . : other events , financial statements and exhibits ( for . .
spotlight innovation subsidiary celtic biotech iowa granted patent by the u . s . patent and trademark office
march 13 , 2018 newly issued u . s . patent covers spotlight innovation’s spinal muscular atrophy drug candidates
press contact rene erickson spotlight innovation inc . 1 - 515 - 274 - 9087 corpcomm @ urltoken investor relations contact mike reysack spotlight innovation inc . 1 - 641 - 512 - 1035 investor . relations @ urltoken
stlt stock price - spotlight innovation inc . stock quote ( u . s . : otc ) - marketwatch
press contact rene erickson spotlight innovation , inc . 1 - 505 - 274 - 9087 corpcomm @ urltoken investor relations contact mike reysak spotlight innovation , inc . 1 - 505 - 274 - 9087 investor . relations @ urltoken
celtic biotech iowa , inc . is a subsidiary of spotlight innovation , inc . additional information available at urltoken .
spotlight innovation inc . ( otcmkts : stlt ) files an 8 - k other events item 8 . 01 other events .
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spotlight innovation does not currently have any hardcopy reports on annualreports . com . click the button below to request a report when hardcopies become available .
on june 20 , 2018 , spotlight innovation inc . issued a company overview that it plans to present to potential and existing investors . a copy of this company overview is furnished as exhibit99 . 1 hereto and is incorporated herein by reference . the company overview is also posted on spotlight innovation inc . ' s website at urltoken
west des moines , ia - - ( marketwired - jun 10 , 2014 ) - spotlight innovation , inc . ( otcqb : stlt ) today announced that effective june 4 , 2014 , celtic biotech iowa , inc . ( a subsidiary of spotlight innovation , inc . ) has completed a share exchange agreement with biopharmaceutical company celtic biotech ltd .
spotlight innovation inc . today announced that it has formed a corporate partnership with university of iowa athletics that will provide ongoing radio and digital media visibility for the venodol brand . . .
pursuant to the share exchange agreement , celtic biotech ltd . is a subsidiary of celtic biotech iowa , inc . , and gains access to spotlight innovation ' s intellectual property commercialization and business development expertise .
as of last trade , spotlight innovation inc ( stlt : qbb ) traded at 0 . 0245 , 29 . 63 % above the 52 week low of 0 . 0189 set on jul 05 , 2018 .
spotlight innovation inc . is a pharmaceutical company . the company is focused on acquiring the intellectual property rights to therapeutics designed to address unmet medical needs . as of june 30 , 2017 , the company had four su
urbandale , ia , april 18 , 2018 - - spotlight innovation inc . , a pharmaceutical company targeting rare , emerging and neglected diseases , today announced that company subsidiary celtic biotech iowa , inc . , reported . . .
spotlight innovation , inc . is a bioscience company , which engages in acquiring the rights and license to proprietary technologies . it operate through its subsidiaries , which identifies and targets technology candidates including cancer drugs and treatment therapies . . .
the fact that we have always hungered for innovation is evident from the history of human kind . this hunger for progress also explains why innovation is the driving force behind economic growth . as innovation transforms the way we live , work and do business , what can we learn from organisations that are harnessing its power most effectively ?
urbandale , iowa , aug . 16 , 2017 / prnewswire / - - spotlight innovation inc . ( stlt ) today announced that the company has entered into a sponsored research agreement with indiana university to support research directed by elliot androphy , m . d . , aimed at developing safe and effective drugs to treat patients with spinal muscular atrophy ( sma ) . dr . androphy is a member of spotlight innovation ' s scientific advisory board and a co - inventor of stl - 182 , the company ' s lead product candidate for sma . geoffrey laff , ph . d . , spotlight innovation ' s senior vice president of business development , commented ,
dr . androphy is a prolific researcher and highly - respected thought leader .
the johnson family’s commitment to innovation and frank lloyd wright’s visionary design have gone hand in hand for nearly 80 years . at our campus , visitors can experience a rich history of exploration and innovation in architecture that has drawn increasing global interest .
cris grunewald , president and ceo of spotlight innovation , said ,
we are extremely pleased to be moving forward with memcine pharmaceuticals ' innovative team and technology . memcine pharmaceuticals ' immunoplex technology has shown enormous potential with broad applicability in both infectious diseases and oncology immunotherapy . memcine pharmaceuticals ' mission directly supports spotlight innovation ' s goal of positively impacting the health and well - being of as many people as possible , and we look forward to furthering the development and fulfilling the promise of this exciting , potentially life - saving technology .
unleashing the power of innovation within the organisation is ultimately the role of the ceo . recognising this , ceos are now taking personal responsibility for directing and inspiring innovation . they’re creating leaders at every level and in every pocket of the organisation to make sure that innovation is not just viewed as the preserve of the chief information officer or research and development . our fast takes on talent innovation series explains that the most successful companies are those that create an environment ‘where the ideas and innovations come from everyone’ .
/ prnewswire / - - spotlight innovation inc . ( otcqb : stlt ) announced today that its subsidiary celtic biotech iowa has received approval from the french national agency for the safety of medicines and health products ( ansm ) to commence part 2 of its phase i dose escalation safety study ,
previous global innovation 1000 studies have long confirmed that when it comes to innovation , it’s not how much you spend , but how you spend it that matters . now it’s also case that where you spend can help to determine your success . innovation could effectively lead to a transformative shake - up of the world order , as we know it – and it might happen sooner than we think .
said tony vanden bush , phd , co - founder , co - inventor , director and chief scientific officer of memcine pharmaceuticals ,
we are excited to be working with spotlight innovation to move the immunoplex platform technology through development and toward clinical use for infectious disease prevention and personalized cancer immunotherapeutics .
organisations must continually innovate if they want to drive rapid and profitable revenue growth . nearly half ( 43 % ) of executives surveyed by pwc for our breakthrough innovation and growth report said that innovation was a ‘competitive necessity’ for their organisation . what’s more , the vast majority ( 93 % ) indicated that organic growth through innovation would be the biggest contributor to their organisation’s revenue growth over the next five years .
the museum also will feature interactive exhibits tied to innovation , driven in part through a $ 10 million donation from urltoken founder jeff bezos . durbin was a bit mum on the plans for the bezos - backed “center for innovation , ” which will open in the fall of 2013 .
from lister’s antiseptic system , to 3d printing organs to assist surgeons in planning complex operations , king’s has contributed significantly to surgical and medical innovation .
a partial report preview for spotlight innovation inc is shown below . where indicated by
yes ,
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west des moines , ia : spotlight innovation – a provider of solutions for healthcare - focused companies , has announced that its subsidiary celtic biotech iowa –a developer of novel clinical trial - phase therapeutic products for the treatment of cancers and pain in humans has entered into an exclusive , world - wide ( excluding china ) license agreement .
spotlight innovation , inc . provides solutions for healthcare - focused companies commercializing healthcare intellectual property developed by major centers of academia in the united states . the company focuses on identifying , validating and acquiring / cooperating with early stage companies developing healthcare technologies including pharmaceuticals , devices and equipment , diagnostic products and healthcare it . additional information available at urltoken .
urbandale , iowa , july 11 , 2017 / prnewswire / - - spotlight innovation inc . ( stlt ) today announced that its subsidiary caretta therapeutics , llc , has engaged transmedia group to provide public relations support for venodol , a new over - the - counter , non - addictive alternative to opioid and steroidal analgesics that is tentatively scheduled to be available in the united states in summer 2017 .
the transmedia team ' s proven track record of generating consumer enthusiasm for products in the over - the - counter category makes them highly qualified to manage the product launch and to implement a product awareness strategy for venodol ,
said john krohn , spotlight innovation ' s president and chief executive officer .
, spotlight innovation ' s president and chief executive officer , said ,
we invested significant time and effort to advance our treatment paradigm using the results of part 1 . we are very pleased that our part 2 protocol was accepted and approved by ansm . this marks a significant milestone for crotoxin as it enters the next stage of clinical testing .
mr . grunewald is president and ceo of spotlight innovation inc . he is an entrepreneur and financial executive with backgrounds in the healthcare and biotechnology sectors , private equity and investment banking . mr . grunewald has been involved in all stages of the commercialization of healthcare intellectual property developed by premiere research and development institutions . prior to spotlight innovation , mr . grunewald served as vice president with an institutional healthcare business incubator where he performed comprehensive operational roles in the formation and development of companies commercializing medical device , it service and therapeutic drug ip . mr . grunewald received a bachelor of science from iowa state university , and served as a united states marine topographical intelligence specialist , receiving extensive military intelligence training from the national geospatial - intelligence agency .
the university of cambridge has signed an agreement with one of china’s largest universities to encourage innovation and entrepreneurship in one of china’s fastest - growing high - tech clusters .
spotlight innovation subsidiary caretta therapeutics’ over - the - counter chronic pain relief product , venodol roll - on , is now available online at urltoken , urltoken and urltoken . venodol roll - on topical analgesic is formulated to provide long - lasting relief from chronic pain associated with inflammation , including joint pain , tendinitis , arthritis ( excluding osteoarthritis ) , and stubborn body aches .
spotlight innovation , inc . is a bioscience company , which engages in acquiring the rights and license to proprietary technologies . it operate through its subsidiaries , which identifies and targets technology candidates including cancer drugs and treatment therapies for disease states , and drug and treatment therapies for infectious diseases . the company was founded on december 12 , 2013 and is headquartered in urbandale , ia .
mr . cristopher grunewald , spotlight innovation ' s president and chief executive officer , said ,
we invested significant time and effort to advance our treatment paradigm using the results of part 1 . we are very pleased that our part 2 protocol was accepted and approved by ansm . this marks a significant milestone for crotoxin as it enters the next stage of clinical testing .
cris grunewald , president and ceo of spotlight innovation , stated ,
we are creating and protecting value for crotoxin as we progress through clinical efficacy trials . the legal protection afforded by the exclusivity of a u . s . patent is an important component of our commercialization strategy for crotoxin , and a significant step in our value - building strategy for celtic biotech iowa .
competition for talent helps to explain why innovation has become a truly global activity . our most recent global innovation 1000 research discovered that the overwhelming majority ( 94 % ) of the world’s largest innovators carry out part of their research and development programmes abroad . innovation spending has boomed in china and india since 2008 and more r & d is now conducted in asia than in north america or europe . the research also found that businesses with a more global r & d footprint outperformed their less globalised competitors on a variety of financial measures .
the integration of science in to technology and in to healthcare has really improved patient care . i’m pleased to say that king’s has been at the forefront of some of that innovation .
about celtic biotech iowa inc . celtic biotech iowa inc . , a subsidiary of spotlight innovation inc . , has developed novel , clinical trial - phase therapeutic products for the treatment of cancers and pain in humans . derived from naturally specialized receptor - binding proteins , these products have the potential to reduce treatment costs , increase survivability , and improve the quality of life for cancer patients . additional information available at urltoken .
west des moines , ia - - ( marketwired ) - - 01 / 15 / 15 - - spotlight innovation inc . ( otcqb : stlt ) announces that its subsidiary celtic biotech iowa inc . has been granted u . s . patent entitled crotoxin administration for cancer treatment and pain relief . the invention relates to crotoxin compositions for intravenous administration and methods of use of crotoxin for the treatment of pain and / or for the treatment of neurologic and neuromuscular disorders .
spotlight innovation inc . ( otcqb : stlt ) announces today that it completed the acquisition of a majority ownership in memcine pharmaceuticals inc . , located at the university of iowa research park in coralville , iowa . memcine pharmaceuticals is developing its immunoplex™ vaccine platform technology , which is designed to use the body ' s own naturally occurring targeting system to deliver vaccine components to immune cells and stimulate a robust response . memcine pharmaceuticals has a licensing agreement for its technologies with the university of iowa .
pankaj chandak was awarded the british science association’s lecture for agricultural , biological and medical sciences . you can book to attend the public lecture , entitled ‘from kings to keyholes : surgical innovation in organ transplantation’ , online at urltoken
spotlight innovation inc . ( otcqb : stlt ) acquires and develops proprietary therapies to address unmet medical needs , with an emphasis on rare , emerging and neglected diseases . the company identifies in - licensing opportunities and manages product development through partnerships with universities , medical schools , contract research organizations ( cros ) , and contract manufacturing organizations ( cmos ) . at the appropriate stage of research and development the company will endeavor to pursue product commercialization opportunities including , but not limited to , out - licensing and strategic partnerships with industry leaders .
seattle’s history is very much tied to innovation , whether it’s bill boeing’s early aircraft or bill gates’ early software . and those breakthrough technologies — as well as dozens of others — are on full display at seattle’s new museum of history and industry .
cristopher grunewald , president and ceo of spotlight innovation and director of celtic biotech iowa , said ,
celtic biotech iowa ' s mission directly supports our goal of positively impacting the health and well - being of as many people as possible . celtic biotech ltd . ' s novel , development - stage cancer and pain therapeutic products for treatment in humans , derived from naturally specialized receptor - binding proteins , have the potential to reduce treatment costs , increase survivability , and improve the quality of life for cancer patients . we look forward to fulfilling their promise .
spotlight innovation inc . , incorporated on may 11 , 2006 , is a pharmaceutical company . the company is focused on acquiring the intellectual property rights to therapeutics designed to address unmet medical needs . as of june 30 , 2017 , the company had four subsidiaries : celtic biotech iowa , inc . ( celtic iowa ) , caretta therapeutics , llc ( caretta ) , sma therapeutics , llc ( sma ) , and zika therapeutics , llc ( zika ) . it is focused on various diseases , including cancer , pain management , zika virus infection and spinal muscular atrophy .
recording and collecting the work of inventors has long been a mission of the smithsonian . the lemelson center of the national museum of american history documents , interprets , and disseminates information about invention and innovation , and fosters an appreciation for the central role invention and innovation play in the history of the united states . the national air & space museum explores the invention , history , science , and technology of aviation and space flight . the anacostia museum has a special exhibit : the real mccoy , african - american invention and innovation , 1619 - 1930 and the remembering gallery ' s exhibit : american inventors and inventions . here we examine a handful of famous amercan inventors , some like benjamin franklin , who are well known for their creations , others such as thomas jefferson , who are better known for other contributions .
innovation is about the application of new ideas , discoveries and inventions . at the university of cambridge , the recipe for success has been ingenuity and creativity , alongside the fundamental research that underpins these ideas , and combined with the constant exchange of ideas between academics and companies , governments and ngos .
west des moines , iowa , nov . 10 , 2016 / prnewswire / - - spotlight innovation inc . ( otcqb : stlt ) announced today that its subsidiary celtic biotech iowa has received approval from the french national agency for the safety of medicines and health products ( ansm ) to commence part 2 of its phase i dose escalation safety study , crotoxin in patients with advanced cancer using an intravenous route of administration . the ansm , a healthcare regulatory agency , acts on behalf of the french government to ensure patient safety . the clinical study will be conducted at pitié - salpêtrière hospital in paris . noted french oncologist david khayat , md , phd , fasco , is the principal investigator .
the 15 - story research tower is the birthplace of some of the company’s most iconic , trusted brands ; like raid® , glade® , pledge® and off ! ® . while it hasn’t been in active use for 30 years , the research tower still remains a visible reminder of the great spirit of innovation that continues to drive the company .
urbandale , iowa , aug . 7 , 2017 / prnewswire / - - spotlight innovation inc . ( stlt ) , a pharmaceutical company targeting rare , emerging and neglected diseases , today announced that its subsidiary caretta therapeutics ' new over - the - counter chronic pain relief product , venodol roll - on , is now available for pre - order in the u . s . at venodol . com . venodol roll - on is a topical analgesic formulated to provide long - lasting relief from chronic pain associated with inflammation , including joint pain , tendinitis , arthritis ( excluding osteoarthritis ) , and body aches . in the coming months caretta therapeutics plans to introduce additional venodol product formats and to expand distribution to mass merchandise retailers through its master broker agreement with a premier global distribution brokerage firm .
as far as innovative cultures go , it’s hard to beat silicon valley right now . what distinguishes silicon valley firms from other companies is their ability to integrate their innovation strategies with their business strategies . these firms identify their customers’ actual needs , figure out how to meet those needs and then get the necessary product or service to market as fast as possible .
due to the huge disruption that digital technology is bringing to every sector , innovation has to some extent become synonymous with digital transformation . pwc’s report , industry 4 . 0 : building the digital enterprise , reveals that industrial and manufacturing companies are digitising every aspect of their businesses , from their product development and purchasing processes through to the way in which they serve their customers . they are investing around 5 % of their annual revenues to achieve this , spending us $ 907bn every year through to 2020 . but successful innovation isn’t just about digital technology . as industry 4 . 0 explains , it also depends on an organisation’s ‘ digital iq ’ – how its people , processes and business model respond to opportunities in this era of rapid transformation .
today , this patient - centered approach and spirit of innovation continues to drive ventana forward . it inspires us to continuously innovate pathology by improving laboratory efficiency and by generating new assays to address unmet medical needs . through the use of automation , laboratory turnaround times have decreased from several weeks to a few days . patients and their physicians spend less time waiting for results , and more time fighting the disease .
spotlight innovation inc . , formerly american exploration corporation , is a bioscience company . the company is focused on acquiring the rights , through acquisition , license or otherwise , to various technologies . the company is engaged in identifying and targeting technology candidates , including cancer drugs and treatment therapies for various disease states ; drug and related treatment therapies for various infectious diseases , and other technology candidates . the company focuses on diseases that are rare , which are known as orphan diseases , or new or common but underserved , such as feline chronic kidney disease . as of december 31 , 2015 , the company had three subsidiaries : celtic biotech iowa , inc . , cdt veterinary therapeutics , inc . and memcine pharmaceuticals , inc . through its subsidiary , celtic biotech iowa , inc . , it develops a range of drug candidates , such as crotoxin , cardiotoxin , vrctc310 and crotamine . through its subsidiary , memcine pharmaceuticals , inc . , it offers immunoplex .
leadership and culture are particularly important given that innovation is becoming more radical . our survey cited above , found that the way in which companies innovate is being transformed as ceos look for solutions that offer entirely new sources of revenue , rather than just better products . an example might be a soap powder manufacturer that decides to open up a chain of launderettes or an engine maker that moves from selling engines to charging users for running them .
on march 29 , 2016 , management of spotlight innovation inc . , with the approval of the board of directors concluded that the previously issued financial statements contained in the company ' s quarterly reports on form 10 - q for the quarters ended june 30 , 2014 , september 30 , 2014 , march 31 , 2015 , june 30 , 2015 and september 15 , 2015 and in the annual report on form 10 - k for the year ended december 31 , 2014 should no longer be relied upon because of an error in recording the value of intellectual property assets acquired in a transaction between the company and celtic biotech ltd . , an irish limited company , that closed on june 4 , 2014 . in the financial statements included in the forms 10 - q and form 10 - k for the prior periods , the company recorded intellectual property assets of $ 6 , 977 , 347 related to the transaction . a subsequent valuation report dated march 29 , 2016 indicated that the value that should have been recorded during the prior periods under generally accepted accounting principles should have been $ 415 , 579 .
to foster innovation in storytelling , we identified the need to cultivate the tools necessary to deliver cross - media storytelling . one of the great advantages of leveraging cross - media and non - linear storytelling principles is the creation of multiple entry points to a particular subject or theme . selection of key emerging technologies allow us to bring attention to those entry points for multi - generational audiences . in addition , creating such methodologies through technology often provides the necessary hooks for media agencies to publicize or otherwise report stories involving themes and content that the museum is seeking to bring to the public’s attention .
in comparison to the in - gallery visitation , online engagement was mostly focused on a single platform . out of approximately 3 , 300 downloads , ios and android only made up 6 % and 3 % respectively . gear vr captured a niche audience 10 times larger than vr on ios and android . in early analysis , it appears that part of that outcome can be attributed to the number of apps available in the oculus store versus itunes or google play . in the month previous to the exhibition opening , there were only 300 apps available in the gear vr ( oculus vr , 2016 ) . weaving a better future was featured by oculus in an e - mail to its press contacts of new apps released . through leveraging an emerging platform , the opportunity to have a spotlight on the project resulted in finding an increased audience and more meaningful visitor experience .
the agreement focuses on developing and marketing a patent - pending invention related to the treatment of acute and chronic nephropathy , use of cardiotoxin for the treatment of chronic kidney disease ( ckd ) . animal studies have shown that cardiotoxin has the ability to inhibit the immune processes that damage the kidneys . this will help to reduce the level of proteinurea , serum creatinine and urea in chronic
this ckd therapy has shown the potential to improve kidney function in a variety of animal models , and we expect to see comparable effectivity as we move this therapy through the clinical trial process . for those people who have experienced kidney failure due to chronic kidney disease , there are currently only two options for treatment - - life - long dialysis or kidney transplant . we would hope that this therapy could be utilized to delay or stop the progression to dialysis or surgery , ” says dr . paul reid , president , celtic biotech iowa .
by anthony g . dupree , cio and ciso , novitex enterprise . . .
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“there are no poisons , only poisonous doses . ” thus did paracelsus , the greatest of the alchemists , encapsulate an important piece of medical wisdom . in fact , that is only half the story , for many materials which are toxic at high doses , when used sparingly and directed at specific targets , are not merely harmless , but actually beneficial . plant poisons , from digitalis to curare , are routinely employed as drugs . and now it is the turn of animal toxins , as researchers examine venoms secreted by snakes and lizards , to see if they , too , might be turned into treatments .
snake venom , collected from farmed reptiles , has been used to make antisera for snake bites for decades by injecting it into mammals such as sheep and horses , and collecting the antibodies thus generated . making drugs from the venom itself , however , is a fairly new idea . but that is what stefan hailey of the university of delaware and his colleagues hope to do . in a paper published recently by toxicon , they report how a protein called eristostatin , which can be extracted from the venom of the asian sand viper , helps people’s immune systems fight malignant melanoma . previous studies have shown that eristostatin stops melanoma cells colonising the liver and lungs in mice . dr hailey is trying to work out how this happens .
eristostatin’s day job is to stop victims’ blood clotting and thus plugging up damaged blood vessels after a bite . by increasing blood loss , it weakens victims . the molecule does this by glomming onto cellular fragments called platelets that are crucial to the process of clotting , thus disabling them . dr hailey hopes to make use of this tendency to encourage the immune system to attack melanoma cells . his idea requires eristostatin to be as attracted to cancer cells as it is to platelets .
two observations suggest it could be . one is that eristostatin has a particular affinity for melanoma cells , which presumably have a protein on their surfaces that is similar to the one which attracts eristostatin to platelets . the other observation is that when eristostatin is attached to a cell’s surface it attracts the attention of t - lymphocytes . these are immune - system cells whose job is to kill other body cells that have been infected with viruses , or which have turned cancerous . if melanoma cells could , in this way , be made especially attractive to t - lymphocytes , that might clear away the tumour completely .
dr hailey and his colleagues used a technique called atomic - force microscopy to study the interactions between melanoma cancer cells and eristostatin . this technique allows the force required to pull the two apart to be measured precisely , to see whether there is a genuine attraction—which he found that there is .
if eristostatin does prove an effective means to treat cancer , it will join a growing stable of medicines derived from reptile toxins . tirofiban , for instance , is a modified version of another anticoagulant—in this case from the venom of the african saw - scaled viper . it is given to people with angina , and also to those who have had heart attacks . exenatide is the synthetic form of a hormone called exendin - 4 that occurs naturally in the saliva of the gila monster , a venomous north american lizard . it works as a treatment for type - 2 diabetes because it increases insulin production in those whose blood - sugar levels are high . and captopril , a blood - vessel - relaxing agent widely used to treat hypertension , is based on teprotide , from brazilian arrowhead vipers , which helps the other toxins in the venom circulate quickly , and thus reach their targets rapidly .
there are other venom - based drugs in the pipeline , too . crotoxin , a protein from the south american rattlesnake , though not yet approved for use , may one day be employed to treat cancers . crotoxin seems particularly attracted to cancer cells . one portion of the molecule recognises a protein on the cell’s membrane , and links to it . the other portion damages the membrane , triggering a mechanism called apoptosis which causes the cell to kill itself . celtic biotech , based in dublin , is running a series of tests using this molecule on cancer patients at the georges pompidou european hospital in paris . this year , celtic plans to try it on people with several different sorts of cancer , since the firm’s researchers believe it should be effective on all solid tumours . if those trials are successful , though , they then plan to concentrate on lung cancer , the largest market .
perhaps the most astonishing toxin - derived drug of all , however , is hannalgesin , which is made from king - cobra venom . kini manjunatha of the national university of singapore is developing this substance as a pain - relieving agent . he claims it is between 20 and 200 times more effective than morphine . moreover , unlike morphine , which is usually injected , hannalgesin can be taken by mouth . he is planning to run the first clinical trials at the end of 2013 or in early 2014 .
venom , then , is proving to be a trove of useful molecules . at a time when drug companies are struggling to develop new products , a novel source of raw materials that have been road - tested by natural selection , and merely need to be subverted from their original purposes rather than created afresh , must be welcome . it is not turning base metals into gold , as paracelsus and his kind once attempted . but as a transformation of matter , it is surely a far more valuable trick .
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an irish biotech company will this week begin human trials of a new cancer treatment derived from rattlesnake venom .
celtic biotech , founded in 2003 by businessmen john reid and dr paul reid , has developed a treatment for advanced cancer from a powerful protein found in rattlesnake venom .
the company will this week begin testing the drug , now known as cb24 , on patients at the george pompidou university hospital , paris , under the supervision of consultant cancer specialist jacques medioni .
celtic biotech expects the trials to last about a year . they are designed to highlight the therapeutic value and safety of the drug .
the irish company discovered a protein in rattlesnake venom that causes malignant cancer cells to self - destruct , a process known as cell death .
two independent studies , by the us national cancer institute and university of texas md anderson cancer center , have confirmed the protein’s anti - cancer properties .
celtic biotech has been researching this for the last seven years and made a number of breakthroughs during that time . it has applied for a number of patents and highlighted its findings in scientific journals .
former assistant us surgeon general , dr roscoe moore jnr , who is on celtic biotech’s scientific board of advisers , says that cb24 provides a “promising approach” .
dr paul reid has a degree in microbiology from trinity college dublin and a masters in neurobiochemistry from imperial college , london . john reid has a masters in management from trinity college dublin .
the company maintains its own colony of breeding rattlesnakes in the us . rattlesnakes are found throughout north america , from southern canada to mexico . they are responsible for more than 80 per cent of snake bite fatalities in the us , and the vast majority of snake bite injuries .
however , they only attack when provoked and the bites are rarely fatal if treated quickly .
about one in four people in industrialised countries are likely to contract cancer within their lifetime . the world health organisation says that the disease killed about 7 . 8 million people in 2008 .
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an irish biotech company has developed a treatment for advanced cancer using a powerful protein found in rattlesnake venom and will begin human trials of the treatment this week , reports the irishtimes . celtic biotech , founded in 2003 by businessmen john reid and dr paul reid , discovered the protein , which causes malignant cancer cells to self - destruct , and has been researching the protein ' s anti - cancer properties for the last seven years . it has applied for a number of patents and has highlighted its findings in scientific journals .
read more : belfast scientists make major breakthrough in prostate cancer fight megan malone set to receive all clear from cancer after u . s . treatment two independent studies , by the us national cancer institute and university of texas md anderson cancer center , have confirmed the protein ' s anti - cancer properties . celtic biotech will begin testing the drug known as cb24 on patients at the george pompidou university hospital in paris , under the supervision of consultant specialist jacques medioni . former assistant us surgeon general , dr roscoe moore jnr , who is on celtic biotech’s scientific board of advisers , says that cb24 provides a “promising approach .
an irish company is using four american diamondback rattlesnakes in a new clinical trial that will test snake venom as a treatment for cancer . the snakes , which hail from the albuquerque biopark , will be allowed to bite something and have their venom extracted humanely . the venom contains proteins that will be extracted and refined to target and kill cancer cells .
snake venom has long shown promise as a treatment for cancer , in a wide range of animal trials dating back several years . celtic biotech isolated a protein in a type of rattlesnake venom that causes malignant cancer cells to commit cell suicide . the company developed a venom - derived drug called cb24 and started testing it on humans at the end of october , working with patients at the george pompidou university hospital in paris . the trial is expected to last a year , and is designed to prove cb24 ' s safety and therapeutic value , according to celtic biotech .
the company has already tested it in mice and in human cell lines with great success . other institutions in the u . s . have independently verified cb24 ' s anti - cancer properties , the company says .
the four albuquerque diamondbacks were sent to the kentucky reptile zoo last week , according to the biopark . there , specially trained reptile curators will extract the snakes ' venom and ship it to paris .
snake venom is potent not only as a paralytic agent and neurotoxin but also as a cancer treatment , celtic biotech says — a little goes a long way . the protein is derived from crotoxin , which apparently has some targeting abilities as well as toxicity . this makes it particularly attractive as a cancer therapy , because it does not harm healthy tissues when it is administered properly . this could make it a useful alternative to other chemotherapies .
celtic biotech has been researching snake venom since 2003 and holds several patents , according to the irish times .
we were thinking this should have occurred to the irish before st . patrick kicked out all the snakes .
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but what does it take to be truly innovative ? well , innovative organisations tend to have a strong learning culture in place . they give their people the time and space to think differently . they also incentivise their people based on the outcomes they achieve , rather than the work they do , so that they have the freedom to take a fresh approach to old challenges . finally , they put in place processes to enable their people to take their ideas to market .
cultural challenges can be an obstacle to ceos , but what else is stopping them from being more innovative ? according to our research , nearly half ( 43 % ) of ceos are being held back by a lack of financial resources while 30 % are struggling to find the right talent .
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racine , wis . , april 18 , 2017 – on june 8 , the 150th birthday of famed architect frank lloyd wright will be celebrated , and design enthusiasts around the world are preparing for special events to commemorate and honor one of america’s most innovative architects .
less than an hour from milwaukee , wisconsin , the sc johnson world headquarters is home to two frank lloyd wright - designed buildings—the administration building ( opened in 1939 ) and the research tower ( opened in 1950 ) . both buildings are on the national register of historic places and open to the public for free tours .
“for almost 80 years , the frank lloyd wright - designed buildings at sc johnson’s global headquarters have served as a source for inspiration for all who visit , ” said kelly m . semrau , senior vice president - global corporate affairs , communication and sustainability , sc johnson . “the research tower is an important part of our company’s legacy . we’re proud of our history and of the opportunity to share it with the public . ”
the company is committed to preserving the history of its wright - designed treasures . in 2013 , the research tower went through an extensive 12 - month restoration , which involved both exterior and interior updates . the research tower was opened for free public tours in spring 2014 .
more than 7 , 000 pyrex glass tubes are featured throughout the tower to construct the building’s numerous windows . if the glass tubes in the tower were laid end to end they would span 17 miles , roughly the size of 586 stacked research towers .
when it opened , there was nothing in place to shade the building from light . it is said that it was so bright in the early days that scientists were issued sunglasses until window shades could be installed .
there are 15 stories and 232 stairs . the tower consists of a series of square floors accompanied by round mezzanine levels . the mezzanine levels were not enclosed , which allowed for easier communication between the scientists .
the research tower is one of the tallest structures ever built on the cantilever principle . it stands 153 feet tall and its central core , which is 13 feet in diameter , extends 54 feet into the ground . all 15 floors of the research tower are supported by the “taproot” core ; much like a tree supports its branches .