black cloud music is an american independent music label based in san bernardino , california .

it was founded in 2006 by santiago garcia ( jynxx ) and yasin .

black cloud music is mainly composed of inland empire natives including noa james , curtiss king , and faimkills .

black cloud music is considered one of the leading independent hip-hop labels in the inland empire .

black cloud music

black cloud music aims to create passionate music from the heart . inland empire based independent label .
hello black cloud , we meet again . by paul collier . sad piano solo ( 150 )
the history of rock music . black vomit : biography , discography , review , links
hello black cloud , we meet again . by paul collier . sad piano solo ( 150 ) - youtube
mix - hello black cloud , we meet again . by paul collier . sad piano solo ( 150 )
black cloud productions ' artist roster is always expanding . please contact us if you would like to be considered for inclusion . click on the artist photos below to access their music and bio .
the title of this music is hello black cloud , we meet again . it is written and performed by paul collier ©2017 i am an unsigned musician therefore your support is everything to me . please click like and subscribe if you want to hear more from me . download coming soon . stress relief relaxing music with binaural nature sounds use this soothing healing music as deep meditation music , yoga music , music for massage , spa music . also could be used as a study music , deep sleep music and total relaxation music . relax your mind and body with this calm music video . use it for zen meditation , concentration and balance , pilates , music therapy . stretching and other relaxing ways or just your daily after work relaxation . epic music . relax your body and mind . wind down . find me on facebook urltoken my website urltoken contact me at paulfromstokeuk @ urltoken
' s music from all their jb ' s and collection stores , which are all located in the hood and supported by black people .
a camel - mounted tourism policeman on the giza plateau looks out over cairo , egypt , which was blanketed by a black cloud of smog in this october 2007 photo .
in cairo , the egyptian environmental agency says the official count of
black cloud days
so far this year is two . last year , there were six . when people first noticed the cloud 10 or 11 years ago , it seemed to hang around for weeks on end .
in cairo , this is the season of the black cloud — the inky haze of pollution that on its worst days descends on the egyptian capital with noxious , throat - burning fumes .
egyptians battle the ' black cloud ' of cairo egypt ' s capital city is blanketed by an inky haze of pollution that on its worst days can bring noxious , throat - burning fumes . most people blame the black cloud on farmers burning agricultural waste . while the government has made some progress in trying to reduce the smog level , it has a long way to go .
the title track and first music video to be released from black cloud off their new full length album
sundogs
coming out on january 16th , 2016 . video recorded and edited by nicholas taylor and lucas pingitore website - urltoken facebook - urltoken instagram - @ blackcloud _ wpg
sara marie barron ' s music appeals to fans of music that meditates on our sadder experiences but always finds a way to guide us through with strength .
world ' s most breathtaking piano pieces | contemporary music mix | vol . 1
black has thoroughly absorbed the memphis sound , incorporating the chugging rhythm , spritely horns , and soulful beats . meanwhile , her voice and method of interpretation echo the greats like dusty springfield , mavis staples , and ann peebles . and let ' s not forget the huge importance of memphis in the blues world as black ' s music bridges the worlds of blues and soul .
the blackest cloud
is the first single from memphis and amy black tells us all about the creation of the song :
a camel - mounted tourism policeman on the giza plateau looks out over cairo , egypt , which was blanketed by a black cloud of smog in this october 2007 photo . cris bouroncle / afp / getty images hide caption
with his mature tracks , it’s not surprising that james got an early start , discovering his skills as a preteen and launching his career at 17 . “ever since then i’ve been dropping mixtapes , eps , lps and albums , ” he says . james connected with ie - based label black cloud music in early 2008 .
02 ) how we make that - shade sheist / n . u . n . e . / nitty black
look out for the music video soon , and check back for exclusive behind the scenes coverage .
in the town of zagazig , the regional hub for farming villages north of the capital , environmental official omar abdelaziz akul says the farmers aren ' t getting a fair shake . he says the black cloud is made up of many types of pollutants .
amy black rediscovered her southern soul on 2015 ' s the muscle shoals sessions , whereas her earlier work placed black firmly within the americana scene . some of us happen to believe that soul music is americana and african american - originated musical forms have largely and wrongly been left out of the broad americana genre . so , in my book , her music still counts as americana as it melds roots music categorizations . for her new album , black went for the memphis sound , home to the all - mighty stax records and their signature horn sound , as well as hi records . titled memphis , the record will release 2 june 2017 on her own reuben records .
well that music video is now available to all through dubcnn and myspace . the single off the album
is home and as such his official site and forums are back in full effect with updates and new music .
the black cloud , a decade - old phenomenon , has been attributed to farmers burning rice straw after their harvest . but studies show there are several contributors to the foul air , and while the government has made some progress reducing the smog level , it has a long way to go .
has been working on music with a passion and devotion that has earned him respect and reognition on a local level .
nothing to do with the music , just the image . you can die fo that color swappin here .
who got his start in music early on . born and raised in atlanta , georgia , 24 - year - old
as we get it , until then enjoy the new music and keep supporting the westcoast ' s pool of talent .
for more information if you ' re interested in hearing verbal threat ' s music and to learn more about the group .
6th march 2017 - as part of the celebrations for the black cultural archives , we present a 60 minute mix of 100 tracks selected by the bca .
black salvation is a band that works the psychedelia into the hard rock with skill , and it makes for a very listenable album in uncertainty is bliss .
october and november are wonderful months in cairo . air conditioners are switched off , windows are thrown open , and warm sunny afternoons give way to cool evening breezes . it ' s a pleasure to be outdoors — except when the black cloud appears . then the coughing starts , eyes water and asthma sufferers and others flee indoors .
in which nashville ' s amy black travels to memphis to immerse herself in the steamy , horn - driven soul and gritty blues of the city ' s musical scene .
] , an artist himself , recognized the lack of west coast representation in magazines and on music charts so decided to create a new outlet .
some funky music right there ! we ' ll be bringing you more from lil uno & chag g soon , so keep it locked right here .
: 9cb68e403f - it ' s that simple ! there are no tie in ' s and no catches - just free quality music , around the clock .
to celebrate the deal they recently signed to take the quarterly urban publication from local to national via distribution with mvd ( music , video , distribution ) .
as such he is keeping his name buzzing by steadily releasing new music to his ever growing fan base . he has recently been putting down some work with
that transitions from black - metal fury to android signals to manic drilling to chaotic sparse noise to languid voices dilated across astral emptiness . those voices segue into the revolving electronic nebulae of the nine - minute
is back on dubcnn with some exclusive music for download . the song we have for you today is the remix to his track
watch how it go down
.
and more ! and if that’s not enough for you “sucker free” will have free music , free giveaways and free access to the hottest hip hop line - up anywhere .
the compton baby gangsta and the l . b . c . dogg pound gangsta spoke about some new music , who knows , we might see something happen in future !
- his first release through paid in full / koch records . as we reported the album features his first enhanced disc as well as exclusive interview footage and a new music video starring
i want to make an impact when it comes to anything i put my hands to whether it ' s music , acting , drawing , or plain out working a 9 - to - 5 . i ' ve been doing this whole music thing since i was 14 years old , and now i got a shorty there ' s no turning back , i ' m a beast anything anyone give me . after i lost a couple people in life since then i ' ve just been on the grind making this music stuff work for me .
this track is a grower ; download it , give it some spins and we guarantee that the melody and lyrics will stick with you all day . expect more news and exclusive music from
. a life - long fan and admirer of ugk , nwa , outkast , old school and alternative music , skillz brings witty humor and lyrical finesse to every track the group unleash .
hopefully now you ' ll have a good idea of what the album will sound like . personally , the record like some fresh summer music , and is gonna be dropping just in time .
to read the details of what has to be done to enter the contest and gain a spot on this mixtape follow the link below and submit your music . hurry though : contest closes on
from watts has been acting and recording r & b ; music for many years now and last year decided to go under a new name , to reveal his rawer hip - hop side .
movement in gaining prominence . having been steadily working he has created a catalogue of music that comprises of just over two albums ; with tracks from some of the most talented producers in the gamer .
are the combination of his creative and innovative lyrical content . he focuses on reality and situations that have occurred in the society around him . behind him is the melodic and soulful , sample - based music from
the release features tracks from mary jane junkeez , i rocc , smigg dirtee , c . g . , tiny doo , clyde carson ( of the team ) black listd , ray c , josh franks & many others and he is currently offering the mixtape for sale on his
, a collective of djs and mc ' s out of san diego , have got together once again to release a mixtape full of the hottest new music and some exclusives , world premieres and freestyles from the west coast .
“a lot of the songs on this album [ are ] very personal and heartfelt , some are also very dark and beautiful , i really put my heart in this album , ” he says . “i would love for my music to be beautiful but there’s a lot of darkness in me . in my music i reflected both and i didn’t separate them—there’s both in all songs . i learned how to accept the darkness and that’s the beauty in me . ”
started writing in the 9th grade . coming from a musical family , ( his aunt was part of the 70 ' s group , labelle ) , it didn ' t take long for him to find his way into music .
“the hi rhythm section and the folks who recorded with willie mitchell are now favorites of mine , but a year ago , i didn’t know about them , ” black admits . “now i’m also a huge fan of o . v . wright and otis clay . and ann peebles - - oh man , i just love the feel of her music ; i love what it does to me . that’s the coolest part of this project - - the exposure to these artists that have become a part of me . ”
( april 4 , 2006 ) - los angeles , ca - it was over ten years ago that tha dogg pound laced the music world with their multiplatinum - selling debut album , dogg food . with bigg snoop dogg again at the helm along with daz dillinger and kurupt a . k . a . young gotti , the bangin ' and much - anticipated new disc cali iz active is re - energizing the golden state music movement and galvanizing the west coast .
if you ask egyptians who is responsible for the cloud , most will point north to the sharkiya governorate , where much of egypt ' s rice crop is planted . farmers traditionally burn their rice straw this time of year , and the smoke adds to cairo ' s already heavy pollution to create a dark layer of smog .
has witnessed and partaken in much of what you hear in the music we call hip hop - yet don ' t assume he encompasses a thug image and is caught up with discussing what heat he holds or how much weight he moved this week .
in one week we have arranged four contests for our readers . today we are proud to launch a contest in conjunction with another music industry giant . you will have noticed while browsing the site that mtv are advertising a special week this week - the
and james does more than rap , as he’s also a local hip - hop promoter ( hosting “the common ground” with lesa j , a biweekly sunday night at riverside’s the vibe ) and helps run bricktoyaface . com , a website featuring artist interviews , show videos and regional music promotions .
putting the team together , gluing it together . i ' m the one that puts everything in the proper perspective . get everyone thinking alike , moving alike , loving alike . let everybody know that it ' s built on love first . if we love each first , the music will kick right in .
air - quality chief ahmed abu sa ' oud says the cloud has had one positive effect — it spurred the government to tackle air pollution problems that have been allowed to grow for decades . in addition to the burning of agricultural waste , he says vehicle exhaust fumes and industrial pollution are major contributors . and he says the smog is worse this time of year because of meteorological conditions that trap the pollution in the lower atmosphere .
i wrote ' the blackest cloud ' during my first scouting trip to memphis last september . i came to town for a week to take it all in - - visit the historic sites , read up on the history , meet with possible producers , tour studios and do some writing . i was camped out in a little bohemian - style studio apartment in the cooper / young district . i would wake up in the morning , brew my coffee and write , still in my pjs . blackest cloud was the first song that came to me . it started with the horn and guitar riff and a beat ( that i worked out by slapping my hands on my legs ) . i didn ' t write with a guitar or keys , just my voice . i moved from the opening riff to the verses and the chorus - - it flowed pretty quickly from there .
well the goverment know him as walter gaines but the neighbourhood know him by his music . graduating from inglewood high in 2002 after swapping and changing schools he opted to head towards a career in hip - hop . when he turned 17 he looked at his life thus far and began to think that this was his calling .
the goal with the melody and groove was for it to be a fun song to sing along with and dance to , but the lyrics go deeper . the meaning is up to the listener . the blackest cloud could be anything from something in their past that won ' t let them move on to a current difficult experience that ' s bringing them down . i tend to carry the weight of the world on my shoulders , which can sometimes make it hard for me to enjoy life the way i ' d like to . i ' ve had some experience with depression , and i know friends and family who deal with it daily . when you are in the middle of it , it ' s like a dark cloud is following you around - - one you can ' t shake . finding hope can feel impossible in these times , but it is the key . i didn ' t give forethought about the outcome of writing and recording a song about this topic - - having to talk about why i wrote it - - but i ' m glad i put it out there . maybe the blackest cloud can encourage those who have this experience to know they aren ' t alone , and there is always hope - - and , on a smaller level , get them a reason to dance around the house . kitchen dancing always lifts my spirits !
whatever you believe it matters not , what counts is that on september 13th 1996 , a little piece of the artform we called hip - hop was lost forever . so raise a glass to the sky , toast a fallen icon and celebrate his life through his music in whatever way you see fit . dubcnn would like to pay its respect to
, featured on mixtapes including
halla the buzz vol . 2
,
dj nicky slicks : rebirth of the west
,
gain green records present - stress : young church vol . 1 & vol . 2
and countless others . he had also featured alongside stress and jellyroll in the music video for the record ;
hot patada .
they dissed the hell out of each other in the early to mid - 90 ' s , they had look - a - likes dress up and kidnapped each other in their videos , and a lot more . the feud between ruthless records and death row records is to this day one of the most publicized beefs and probably the one that generated the hottest music .
killa klump is poised for a takeover with his new album
foundation
, and continuing the rah muzic movement of the super - hyphy sound that has become the bay area’s new signature sound . klump , born noah kerrien , is not new to the game , his father david wrote and worked with people like michael jackson in the early 80’s . klump was born with music in his soul . he started out in talent shows singing and developed a love for music . “this was in me before i was even born… . my dad is a musician , my grandmother use to sing at functions and it is what it is , it’s in my blood” . klump has worked on albums and mixtapes such as louieloc’s “power moves , ” ctdc’s “the arrival , ”
the mixtape was hailed as an underground gem and gave them the chance to headline a new years eve show . over the year that passed the duo went their separate ways due to creative differences . now older and wiser , they find themselves still in the music industry tired of the politics and restrictions but with a common goal of helping bring real hip - hop to the masses once more .
the video was shot all over memphis by stacie huckeba who is nashville - based but has a deep connection with memphis . we did an eight - hour shoot with 28 full takes of the song - - and energy remained high to the end ! we started at the top of the bass pro shop pyramid , where i danced myself dizzy on the observation deck , entertaining the diners ( think flashdance ) , moved on to a walking bridge that had us out over the middle of the mississippi river , then to beale street and lastly to the bar that claims to be the oldest in memphis , the lamplighter , where our gracious bartender ann , who has been there for 40 years , let us film . you can catch her cameo ( my favorite moment ) at the end of the video . on days like these , that black cloud is nowhere in sight ; it ' s all sunshine - - i ' m living my passion and falling more in love with a city that increasingly holds a special place in my heart .
we want to showcase the premiere new west hip - hop & r & b ; talent for a & rs ; , radio stations , labels and fans to see what the music is all about . we are offering one last spot on the mixtape to a new westcoast artist ( hip - hop / r & b ; ) that wants to be a part of this mixtape . you will be featured alongside names such as
is a proverbial sponge , he soaks up what he sees and he lays it out for others to interpret ; he sits between what some would call a
backpack
rapper and what the mainstream is used to ; exactly the kind of artist needed . he has real charisma , real emotion and when you hear him you can feel that passion that drives him to make music . . . the same passion that has earned him the accolades and the attention .
i finally got to really sit down with tyrese this week at his headquarter offices and check out his album and new mixtape . all i can say is wow . black ty has some shit for real , people have been doubting him getting into the rap game but he not only can spit , he really paints a picture with each song . check out his mixtape for the warm up , and make sure you stay tuned for his album . he ' s got everyone on it and the lead single is a banger . . . do not sleep and open your eyes !
ras and i were at element by ourselves and had ran into game several times that night . nothing was said at anytime . toward the last 15 minutes of the club all of us were standing on stage where the vip section was held that night , game calmly aproached ras to talk to him and ras turned around not acknowlding him . game then gave ras a cheap shot with a bottle while ras was turned around . ras fought back as i was dealing with others from the black wallstreet camp . security quickly stopped the fight and all involved were escorted out . ras is perfectly fine no damage done .
as well as a guest writer for dubcnn , conan also writes for publications including allhiphop and uk based publication
hip hop connection .
conan is always looking for new assignments , and any labels interested in the possibility of having their music reviewed or featured on dubcnn or in another of those leading hip - hop outlets . as such he wants both new and established acts to increase their promotion on a global scale by contacting him via email directly or via dubcnn . for examples of his work visit our
resonance is a trail - blazing , not - for - profit radio station dedicated to the arts and culture . from its launch in 2002 , its award - winning programming has given voice to the vibrant diversity of london & apos ; s thriving arts and music scenes . resonance & apos ; s pool of creatives speaks directly and expressively to an engaged and passionate audience , locally , nationally and internationally . our 24 / 7 broadcast service combines its fm signal in the city with dab digital radio coverage across greater london .
the song was recorded at electraphonic on the first day of our sessions - - this was the day we had some of the next generation memphis players in the studio - - joe restivo from the bo - keys on guitar , al gamble from st . paul and the broken bones on keys , george sluppick on drums who just returned to memphis after living in la for several years and touring with chris robinson , joined by hi rhythm great leroy
flick
hodges on bass . later we added memphis horns arranged by marc franklin , who also plays the killer trumpet parts , and long - time memphis soul sirens , reba russell and danielle hill sang background vocals - - i joined in too to give it three parts . we recorded the album on 8 - tracks and had only one available for backgrounds on ' the blackest cloud ' , so we all jumped on the mic and did it together .
i didn ' t intend to alienate all arabs with that song , i just wanted to paint an accurate picture of what ' s really going on in our hood to provoke thought , letting black people know that we don ' t have to support those that do not have our best interest at hand . i had no beef with the arab clothing store owners because i didn ' t think it applied to them , but obviously they think it does . therefore , i say that i have no problem with any arab that respects our people and treats them with the same dignity that they treat their own with . however , i say - - - - you to all you bloodsucking arabs that have done nothing but leach off of our community for the longest and treat us like shit . i have no respect for you and no love . i will never shop with you again for attempting to ban and censor the truth . u will - - - - around and get banned from our community . as the last line in the song says ,
i know you think that we stupid , and u feel like we clowns , but we reserve the right to shut ya ass down ! ! ! ! !
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james lists his musical influences as rakim , nas , big pun , bobby blue bland , b . b . king , maxwell and jill scott . non - musical inspirations include his grandparents , animal planet , wrestling , anime cartoons and greek mythologies . ( yes , it’s an interesting gathering . )
local hip - hop artist noa james tells us that he’s also known as “intelligent , ” “elegant” and “elephant . ” though we’re not sure on that last one—we’ve never compared indie rappers to pachyderms—we can say the rhymes james delivers are definitely smart , and they’re served in a way that’s not harsh . hey , two out of three’s not bad .
james says he’s seen the local hip - hop scene grow over the past couple years , with more colleges presenting events , clothing boutiques hosting hip - hop mixers and venues more willing to throw hip - hop shows . “even artists outside of the ie are wanting to come and make the ie a touring stop because they are now hearing about the hip - hop scene out here , ” he says .
local gigs for james have been solid , including a gig where “everyone went nuts , ” he recalls . “the owner of the spot had to stop the performance and tried to get everyone to calm down and sit back down . i was surprised that so many people knew the song and it got the reaction it did . ”
james will likely score more reaction with the release of beautiful darkness , which was recorded in san bernardino and scheduled to hit this week .
noa james at the vibe , 1805 university ave . , riverside , ( 951 ) 788 - 0310 ; urltoken . sun , 9pm .
is a household name on dubcnn , and took that task upon himself . sometime last year he let me hear his version of
, but we decided against releasing it at that time . people weren ' t ready ! now it ' s 2006 , people got a better understanding of who 40 glocc is , and through his infamous / g - unit affiliation , the world got to see him on
) blazing radio stations nationwide , and his buzz steadily growing , i thought now would be a good time to let ya ' ll get a glimpse of some , you might say , different hip - hop .
opening up for them , and they ' ve been tearing down every venue they hit . on the 28th , they stopped in portland , or and our forum member
was present and posted a detailed review , aswell as a series of pictures from the show .
first off , let me start off by saying that i have been to this venue ( the roseland theatre , in downtown portland ) many times . . . . seen many concerts there , but i have never see a show packed like this one ! i mean , you had to almost have a snorkel that was 6 ft tall in the air to get fresh air to your lungs . . . . that ' s just how packed this place was !
next up ice cube & wc were brought to the stage by dj crazy toones . they did about an hour set where the performed hits such as
jackin for beats
,
today was a good day
,
bow down
,
the streets
,
gangsta ' s make the world go ' round
,
natural born killaz
, and many others . at one point , before going in to
bow down
, wc declared himself & ice cube as
the real westside connection
. of course mack 10 was never mentioned throughout the night so i guess their ' s still decension between the camp .
is back with his new solo project
i luv cali
. the album was entirely produced by
, and is dropping as scheduled on may 16th through west coast customs / street light entertainment , with distribution through fontana / universal records .
also be on the lookout for scodie ' s other projects dropping soon after
i luv cali
. first off the project with bad azz entitled
get a cup
, and his next solo album with
i got another solo album i ' m working on that ' s gonna be executive produced by kurupt & scott storch , that ' s coming through west coast customs / scodie mac / scott storch productions . that ones gonna be real big , he ' s even talking about bringing it to dr . dre . we ' ll see what happen , but me and scotty have been pumping out some heat
just hit me up with a brand new exclusive freestyle he recorded for ya ' ll . he ' s been under the wing of
for a little while now , and is currently blazing the streets with mixtape joints , while finishing up his debut album .
now if that isn ' t enough to make the world sit up and take note i don ' t know what is . enter ;
at 25 he has already been in the game making records on a professional level for a decade however only now is he set to make the transition to the forefront of the public - eye .
surely it ' s time you respected the hustle and started to listen to the material that brought him that respect ? get ready then . . .
; not bad for a first attempt . since then he has been working even harder and in the fall of 2005 released ;
verbal accolade makes an appearence as an album skit [ available below ] . the album encompases work from the
native the world at his feet . . . only time will tell what ' s next for
, one thing is for sure ; this is not the last time we will be hearing from him .
as well as talking to labels ; stay tuned to dubcnn for the latest . in the meantime visit
. equipped with slick punch lines and metaphors but with the ability to construct a track which comprises a concept and concise structure .
in these days where everyone and they momma is a rapper his kind is a rarity and welcome addition to the talent that is floating around the westcoast . since his senior year of high school
is currently pitching his demo to labels and a & r ; ' s to land the coveted prize of a record deal . with the
( pronounced wi - fee ) ] behind him and the westcoast as a whole beginning to take note he has plans to create a platform for himself and others to showcase themselves .
as a talented songwriter he brings a fusion of r & b ; & hip hop to enable him to be receptable to a wide audience while still maintaining the essence that has created his buzz . his flow on the tracks we have to showcase below give you the chance to see how he can switch up and hop on any production that may come his way .
the emphasis behind the work and the grind has been his mother , daughter and son who give him the urge to succeed in this industry and as such you can usually find him locked in a studio day and night recording or performing shows to get his foot in the door . believe the hype , listen to the energy and embrace the fresh sound of
( feat . lisa ) ( produced by . t . h . x . )
don ' t sleep on these tracks , feel free to spread them around and dj ' s give them play . look for more from
mac dre tribute event @ vault 350 with mistah f . a . b . & n . v .
a group we have featured many times on dubcnn . the show order is scheduled to run as ; dj : 8 : 30 - 11pm ,
: 12 : 30 - 1 : 15am . click the image to the left for the full event flyer .
website for only $ 20 , vip advance $ 30 or for $ 40 on day of show .
your favorite website ' s favorite website is back again with yet another exclusive special . once again dubcnn hooked up with
interviews . to make it simple , they mainly focus on the new dpg album
cali iz active
and break it down in details . the dogg pound gangstas talk about the making of the album and how
check out this exclusive interview by hitting the link below , and stay tuned on dubcnn for some exclusive footage from the
cali iz active
video shoot .
don ' t forget that the upcoming dogg pound album
cali iz active
will be hitting stores in exactly 2 months , on june 27th .
, which is being released through state county / bungalo / universal records . the first single ,
, titled
the chemistry files vol . 1
, dropping april 25th .
on behalf of governor snoop , april 22 is now called
west coast independence day
. during this past weekend , the entire west coast got together to show that
snoop dogg , daz dillinger , kurupt , battlecat , julio g , fred wreck , dj quik , ice cube , wc , king tee , roscoe , warren g , too short , kam , xzibit , soopafly , tyrese , mc eiht , mykestro , glasses malone , bishop lamont , j . wells , playa hamm , jelly roll , terrace martin , krondon , dilated peoples , big boy , jt the bigga figga , daddy v , crazy toones ,
it was a beautiful display of west coast unity , something that the we have been missing for a long time . this video will definitely be considered a milestone in west coast history .
-
look . . . this remind me of
g thang
video , you know that video is like 12 years old , we haven ' t had this kind of comradery in a long time , so its wonderful .
to host his album sampler on dubcnn which was leaked to the internet yesterday following it being given out at the first set of concerts .
- an artist featured on dubcnn many times and co - signed by copious names in the industry .
native who was nominated for
best west coast mixtape artist
has linked up with
l . a . ' s mixtape king
keep his material in regular rotation on 100 . 3 the beat and power 106 . countless mixtape dj ' s including
talent as well as media outlets including ourselves providing regular updates and features on the new west talent .
( de la soul , pharcyde , common , erykah badu ) . as far as guest appearences on this release
has paid his dues now and its time those sleeping woke up to the talent he possesses . as ever to aid your decision to support the release and the westcoast as a whole we have the tracklist and snippets right here .
01 ) die slow ( feat . pc & nonispits ) [ produced by daeone ]
05 ) living in hell ( feat . roccett ) [ produced by embryo ]
07 ) next to me feat . taje , blue rose , z - cali , problem , pc & bangloose ) [ produced by demjointz ]
11 ) street dreams ( feat . chevy jones ) [ produced by daeone ]
12 ) gob stopper ( feat . bishop lamont ) [ produced by j dilla ]
as always stay tuned to dubcnn for the latest on the d . p . g . as well as checking out the official website of the
. for dubcnn regulars you will have seen this track just the other week ; lookout for his album dropping soon on rap - a - lot records .
as always support the artists releases when in stores and stay tuned to dubcnn for the latest news , interview , features and of course media .
poverty was the least of his worries as he watched countless friends and family members die or get senselessly murdered .
now when you try and distinguish yourself as an artist you can rely on only a few things , your voice , flow and lyrics . now although flow can be switched and lyrics can be improved your voice ' s texture is always going to be a factor . . . can people ' feel ' your passion ? encompassing genres to his musical outlet has helped
grow as an artist and as such the flavour he brings on different cuts give different angles to his persona .
and had praise from mr . rodney o . collaborations have been a key aspect to his rise in local circles and aims to take it to a wider level in terms of exposure .
gain green records present - stress : young church vol . 1 & vol . 2
to be featured on dubcnn again as we keep up with his releases and latest news . in the meantime you can visit his label ' s website
mixtapes as well as his as yet untitled debut album . in the meantime visit
video feature we brought ya ' ll a few weeks ago , will know what kind of pull nitty gritty has , and what he ' s about . nitty has been grinding for the west coast for over a decade , and has now arrived at his destination . the launch of
operation save the west coast
makes nitty ' s quest official . the dvd is dropping in summer , and you ' ll be able to witness some vintage west coast footage , and watch nitty do what he does best , polickin ' and networking .
enjoy the trailer , and we ' ll keep you posted on future developments regarding this project .
it promises to be a monster album with top notch production and few guest appearances .
, the miami emcee was blessed to have omar cruz drop some cali hustle on this hustlers anthem .
they said we couldn ' t rap , they said we couldn ' t trap , well ask t . i . about l . a . , bet he know about that !
at the point of the song . if you liked this remix with just busta on it , you won ' t be dissapointed with this latest version . shouts to
suga free , bad azz , 40 glocc , glasses malone , w . s . bugg , kokane , ese daz ( spanish fly ) , ca $ ino , bokie loc , nek - one , infra - redd , blaze
young brown has been recording on the album for over a year , and has been on his grind performing and opening up shows for suga free & glasses malone amongst others and toured overseas aswell . he recently shot a video for his single
i have two exclusive joints from the album for ya ' ll to download from the 21 - track deep album . the first one is the single ,
record . we will naturally keep you updated on the album , and bring you more audio in near future .
for a guest appearance . they laid down the vocals a couple of weeks back , and the song is scheduled to appear on snoopy ' s next solo album
the blue carpet treatment
, due out later this year .
this project will surprise a lot of people , as it will have a total different vibe than his last album
r & g : the masterpiece
. and this feature with e - 40 is another indication for a switch - up .
has already started working on his next solo album which is still untitled . he ' s putting it out on the major market through snoop ' s doggystyle records at the end of the year ( snoop also took over the executive producer role ) . so far they recorded 6 songs , the first 3 songs are produced by
. until then , watch out for kurupt ' s upcoming underground project
same day , different shit
, and of course the dpg album
cali iz active
which is out in stores june 27th .
' s
explosive mode 2 : back in business
in our last weekend audio . dubcnn would like to remind everybody out there that the album was officially released this week and is on sale now .
the album is a nice follow up to volume 1 , and fans are already debating on different things about the album , such as the length as it ' s only 10 songs and 2 skits . the album is indeed short but sweet in the song selection , with
the overall production is very good and it gives the entire album a very melodic vibe . there aren ' t any guest appearances on the album , which is good because people requested messy marv and san quinn and that ' s what they get from start to finish .
; dj warrior , dj strong & the team at hiphopwest . leave feedback over at the dubcc
, from new jersey , has been declared as top priority by executives at the label . as such he is currently working on his major label debut .
on the smack dvd . the cd also features an enchanced disc with bonus tracks .
, the future looks bright for the young artist . a tour is planned to support the album release and raise
profile . as ever dubcnn has audio from the project for you to listen to before you place and order .
surely will ; with its light ' keys ' intro that lulls you into the song with its melodic feel and unbelievable catchy hook . . . you ' ll soon be wondering when you hear the tracks if we have stumbled across something a little special with this artist .
where he wrote and performed lyrics for the hook . he has since worked with various producers such as ;
run by himself and partners bubba and mac jackson . due to the extensive street buzz and credibility created in california along with the street team and own promoters , the album has managed to sell over 3 , 000 copies in los angeles alone since january 2006 .
page to hear more audio and to read more details on him . to order a copy of the album click
has been on the scene for over two years he may not be a name many are familiar with . as such he is planning to release a new mixtape to raise the attention focused on
03 ) ray - c - what you lookin at ( prod by . josh franks )
07 ) josh franks - parlay with us ( feat . sb , ray - c & dolla phil ) ( prod by . josh franks )
08 ) i rocc - hood survivors ( feat . smigg dirtee & j . cin )
11 ) c . g - been there ( feat . clyde carson of the team ) ( prod . by vince v )
14 ) keak da sneak - aaddiimean ( remix ) ( feat . 12 g tha livewire )
; specifically gangs who have a problem with jim jones and dipset claiming blood and wearing purple . as they put it ;
we brought ya ' ll the track last week but it was slept on , and i just got the dirty and radio edits for all you dj ' s out there , so i thought i ' d give ya ' ll another heads up on the song . so make sure you go ahead and grab which ever version suits you and bang the track , cause 40 is on his way !
in related news , the whole infamous camp ripped the funkmaster flex show in nyc on monday , those of you who caught it know what i mean . as ya ' ll know , this is where you get your 40 glocc fix , and i ' ll be back in a hot second with some more !
have probably noticed that the dpg talk on there has picked up massively . with jd finally getting behind
record dropping in june , it looks like the future is pretty bright for the rap veterans .
. no word on who produced it yet , we ' ll keep you updated on that . listen to the song below :
has been making quite some noise . the song was produced by jermaine dupri and is a preview of the so so gangsta album . listen below :
stay tuned for the latest on the d . p . g . right here as always ! also check out the new official website
the result is a hot joint to kick back to , so as they say , ' take a lil time ' to let this soak in . today is 4 / 20 , all the smokers out there know what that means , so roll one up and enjoy the day !
; which will be out later this month in c . a & n . y . , and more about his future plans .
himself for a beat and guest feature . he hooked me up with the track for ya ' ll to check out aswell , so here it go :
another week , another dubcnn exclusive . this time we present an exclusive video interview with an artist who has been in the game over a decade now - enjoying both group fame and solo success .
who over the years has been an influence and a prescence few possess in the world of hip - hop . we discussed how the
august 5th and 6th , all of california will be in for a treat . guerilla union is back again with yet another monumental hip hop festival . with names like


santaris pharma a/s is a biopharmaceutical company founded in 2003 in copenhagen , denmark with a small branch in san diego , california that opened in 2009 .

created by a merger between cureon and pantheco , santaris pharma a/s has become a leading clinical-stage biopharmaceutical company that develops rna-targeted medicines using a locked nucleic acid ( lna ) drug platform and drug development engine .

the company was acquired by roche in august 2014 .

santaris has the worldwide exclusive intellectual property rights to the therapeutic applications of locked nucleic acid ( lna ) technology .

this includes ownership of over 60 patent types , which range from the chemistry to manufacturing and from therapeutic uses to drug design .

with their lna technology , santaris works on developing drugs for a wide range of diseases using microrna and mrna .

their research focuses on infectious disease and metabolic disorders .

they also work on collaborations with pharmaceuticals to develop drugs for rare genetic disorders , cancers , cardiovascular disease , and immune and inflammatory diseases .

santaris pharma

2 santaris pharma , kogle allé 6 , dk - 2970 hørsholm , denmark .
in 2010 , exiqon initiated arbitration proceedings to defend its business against santaris pharma .
said søren tulstrup , president and chief executive officer , santaris pharma a / s .
isis pharmaceuticals , inc . v . santaris pharma a / s corp . et al
bristol - myers squibb is teaming up with santaris pharma to discover and develop novel medicines using santaris pharma ' s locked nucleic acid ( lna ) drug platform . santaris pharma is a biopharmaceutical company focused on developing medicines targeted to disease - related mrnas and micrornas .
for access to santaris pharma a / s lna technology for the development of rna - targeted drugs . santaris pharma a / s is eligible to receive milestone payments of up to
between santaris pharma a / s and wyeth , which was acquired by pfizer inc . under the terms of the original collaboration , santaris pharma a / s received an upfront payment of
said henrik ørum , vice president and chief scientific officer at santaris pharma a / s .
santaris pharma – according to an aug 4 , 2014 press release , roche announced that it has agreed to acquire santaris pharma based near copenhagen , denmark . santaris pharma has pioneered its proprietary locked nucleic acid ( lna ) platform that has contributed to an emerging era of rna - targeting therapeutics .
santaris pharma owns the worldwide exclusive rights to develop innovative new drugs based on lna technology . santaris pharma and h . lundbeck will collaborate on the development of potential neurological drugs arising from the platform .
j . donald debethizy , president and ceo of santaris pharma , said , “roche and santaris pharma have complementary capabilities… the acquisition combines santaris pharma’s next - generation antisense technology and lna expertise with roche’s deep experience in disease biology , chemistry , drug safety , drug formulation , delivery , and development . ”
santaris pharma is a danish clinical stage biopharmaceutical company . the company was formed in 2003 and has the exclusive rights to lna technology , used to develop new classes of rna medicines , called rna antagonists . santaris pharma
“roche and santaris pharma have complementary capabilities that will help us realize breakthrough medicines , ” stated j . donald debethizy , president and ceo of santaris pharma . “the acquisition combines santaris pharma’s next - generation antisense technology and lna expertise with roche’s deep experience in disease biology , chemistry , drug safety , drug formulation , delivery , and development . ”
santaris pharma a / s announces expanded worldwide strategic alliance with pfizer inc . directed to development of rna - targeted med
santaris pharma a / s announces expanded worldwide strategic alliance with pfizer inc . directed to development of rna - targeted medicines
santaris pharma is a danish clinical stage biopharmaceutical company . the company was formed in 2003 and has the exclusive rights to lna technology , a 3rd generation antisense chemistry used to develop new classes of rna medicines , called rna antagonists . santaris pharma
santaris pharma a / s uses its proprietary locked nucleic acid ( lna ) platform and tissue - targeting expertise to pioneer next - generation antisense product candidates . santaris pharma is developing a diverse pipeline of lna therapeutics that influence the production or activity of select rna targets to address diseases that are difficult - to - treat with conventional drug modalities . santaris pharma’s innovation and leadership position has attracted multiple collaborations with leading global pharmaceutical companies . founded in 2003 , santaris pharma is headquartered in denmark .
wyeth pharmaceuticals is continuing efforts to improve its capabilities in the formulation and delivery of rna through a strategic partnership with santaris pharma .
since gilde invested in santaris pharma , the company has advanced its product pipeline through the clinic and signed commercial collaboration agreements with glaxosmithkline , pfizer , bristol - myers squibb , roche and shire . santaris pharma was acquired by roche in 2014 for $ 450m .
santaris pharma randi krogsgaard , + 45 4517 9879 director , corporate communications cell : + 45 20488384 rmk @ urltoken www . urltoken
santaris pharma a / s announces expanded worldwide strategic alliance with pfizer inc . directed to development of rna - targeted med | fiercepharma
rana therapeutics , inc . and santaris pharma a / s announce agreement to develop rna - targeted medicines that selectively activate protein expression
exiqon had requested that santaris pharma be ordered to pay damages . however , the arbitration court did not find grounds for damages .
the award is the first program grant to be made by the atf and is the third and largest award from the danish atf to a santaris pharma led collaborative group . the three year program will enable santaris pharma to identify 3 - 5 new rna drug candidates . in 2006 and 2007 the atf made two separate project grants to santaris pharma and the university of copenhagen totaling approximately dkk 20m (
santaris pharma a / s announces expanded worldwide strategic alliance with pfizer inc . directed to development of rna - targeted medicines | mirna blog
we would like to thank our colleagues at santaris pharma and all our collaborators who have contributed to the miravirsen endeavor over the years .
equity investment in santaris pharma a / s . santaris pharma a / s continues to be eligible to receive milestones and royalties under the original alliance . pfizer has advanced several programs under the original collaboration and reached a number of early milestones since the inception of the collaboration .
roche announced that it has agreed to acquire santaris pharma . santaris pharma has pioneered its proprietary locked nucleic acid ( lna ) platform that has contributed to an emerging era of rna - targeting therapeutics . this new class of medicines has the potential to address difficult to treat . . .
as the leader in developing lna - based drugs , santaris pharma a / s is very pleased that the uspto has ruled in favor of santaris pharma a / s and upheld the company ' s ' imanishi ' patents ,
said soeren tulstrup , president and ceo of santaris pharma a / s .
the uspto rulings affirm the strong intellectual property position of santaris pharma a / s as it continues to develop effective rna - targeted therapies with high affinity , target specificity and remarkable potency for a range of diseases both internally and with its partners .
santaris pharma a / s announced it has established operations in the united states . increasing interest , new collaborations and breakthrough advancements utilizing the company ' s proprietary rna - based locked nucleic acid ( lna ) drug platform and drug discovery engine led santaris pharma a / s to . . .
roche announced that it has agreed to acquire santaris pharma . santaris pharma has pioneered its proprietary locked nucleic acid ( lna ) platform that has contributed to an emerging era of rna - targeting therapeutics . this new class of medicines has the potential to address difficult to treat . . . more
exiqon a / s ( nasdaq omx copenhagen : “exq” ) today announced that the company has completed its litigation against santaris pharma a / s .
a drug for hepatitis c virus from santaris pharma shows effectiveness in reducing the potentially deadly virus in people , according to new clinical trial results .
santaris pharma a / s announced it has established operations in the united states . increasing interest , new collaborations and breakthrough advancements utilizing the company ' s proprietary rna - based locked nucleic acid ( lna ) drug platform and drug discovery engine led santaris pharma a / s to . . . more
roche ' s return to the field of rnai research looks to be complete , following its $ 450m deal to acquire denmark ' s santaris pharma .
denmark - based santaris pharma a / s appoints leading rna industry expert art levin ph . d . as president of us operations and chief development officer
, phd , vice president and chief scientific officer of santaris pharma a / s .
santaris pharma a / s has dedicated its scientific know - how and expertise to advance lna - based chemistries into a versatile lna drug platform for the development of new rna - targeted drugs for human diseases .
roche announced that it will acquire santaris pharma , a private clinical stage biopharmaceutical firm focused on rna - targeted therapies , for up to $ 450 million .
santaris pharma will receive an up - front payment of $ 10 million , up to $ 90 million in potential milestone payments per product , and funding of ongoing discovery and research activities . in addition , santaris pharma will be eligible to receive royalties on the worldwide sales of all medicines arising from the alliance .
6m , $ 9m ) towards the development of a high - throughput drug discovery platform for novel rna medicines . the project will be based on santaris pharma
during proceedings , santaris pharma submitted a counter claim against exiqon for damages in the amount of dkk 100 million . this claim was dismissed on substantive grounds .
hørsholm , denmark / san diego , california , january 09 , 2014 —santaris pharma a / s , a privately held biopharmaceutical company , announced today that they have signed a worldwide strategic alliance with roche to discover and develop novel rna targeted medicines using santaris pharma ' s proprietary locked nucleic acid ( lna ) drug platform .
roche has renewed its interest in gene silencing drugs , paying $ 250m ( €187m ) for santaris pharma including its ‘antisense’ locked nucleic acid ( lna ) platform .
“we are pleased that dr . levin has joined our management team to establish operations in the us and oversee global development programs for santaris pharma a / s , ”
the arbitration court also decided on the distribution of the costs of proceedings . santaris pharma was awarded partial costs of dkk 2 million payable by exiqon within 14 days .
roche plans to maintain santaris pharma’s operations in denmark , where the existing site will be renamed roche innovation center copenhagen . under the terms of the agreement , roche will make an upfront cash payment of $ 250 million to santaris pharma shareholders and make additional contingent payments of up to $ 200 million based on the achievement of certain predetermined milestones .
following today’s decision , it is clear that both exiqon and santaris pharma may supply lna™ products for the research and development of pharmaceutical products containing lna™ as the active ingredient .
santaris pharma discovers and develops rna - targeted therapies to treat infectious diseases and metabolic disorders . through its partnerships with pharmaceutical companies , santaris covers a range of therapeutic areas including cancer , cardiovascular disease , infectious and inflammatory diseases , and rare genetic disorders .
roche said it will retain santaris’ operations in denmark under the new name roche innovation center copenhagen . the acquisition of santaris is expected to be completed this month .
the second edition in our pharma social media series , the uk twitter ranking . . . .
neither santaris nor isis commented on the dispute for this article , citing ongoing litigation .
formed in 2003 , santaris has not been short of big pharma interest in its technology , having sealed deals with companies such as bristol - myers squibb , glaxosmithkline , pfizer and shire .
navjot rai santaris pharma a / s , usa office : + 1 858 764 7066 ( ext . 206 ) cell : + 1 619 723 5450 e - mail : nra @ urltoken
that history includes a patent dispute between santaris and isis , generally acknowledged as the pioneer behind antisense drugs . isis sued santaris in august 2011 over patent infringement claims . the u . s . patent and trademark office ruled in favor of santaris in november 2011 .
s messengerrna antagonists and microrna antagonists are being developed to silence mrnas and micrornas associated with various diseases , including cancer , metabolic disorders and viral infections . santaris pharma completed a euro 40m second round of equity financing in may 2006 and a euro 20m third round of equity financing in december 2007 . santaris pharma has a global alliance with enzon pharmaceuticals of new jersey to develop and co - commercialise a series of santaris pharma rna antagonists for the treatment of cancer and a worldwide strategic alliance with glaxosmithkline for the discovery , development and commercialization of novel medicines against viral diseases .
the acquisition , which is subject to customary closing conditions , is expected to close in august 2014 . roche plans to maintain santaris pharma’s operations in denmark , where the existing site will be renamed roche innovation center copenhagen . under the terms of the agreement , roche will make an upfront cash payment of usd 250 million to santaris pharma shareholders and make additional contingent payments of up to
the deal will see wyeth select rna targets that santaris will develop drug candidates for using its lna platform , with the pharma major responsible for the development and commercialisation of products arising from the alliance .
under the terms of the agreement , santaris pharma and roche will collaborate on the discovery of lna drugs against a multitude of targets across several disease areas . roche will be responsible for the subsequent development and commercialization of products arising from the alliance . santaris pharma will receive an upfront payment of $ 10 million in cash , up to $ 138m in potential pre - clinical , clinical , regulatory and sales milestones per product , and funding of ongoing discovery and research activities . in addition , santaris pharma will be eligible to receive royalties on the worldwide sales of all medicines arising from the alliance .
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/ prnewswire / - - santaris pharma a / s , a clinical - stage biopharmaceutical company focused on the research and development of mrna and microrna targeted therapies , and pfizer inc . ( nyse : pfe ) , today announced that the companies have expanded their collaboration directed to the development and commercialization of rna - targeted medicines using santaris pharma a / s locked nucleic acid ( lna ) drug platform .
the santaris pharma a / s lna drug platform is the only rna technology with both mrna and microrna targeted drugs in clinical trials , demonstrating the broad utility of the proprietary platform . the unique combination of small size and high affinity achievable with santaris pharma a / s lna technology allows lna - based drugs to potently and specifically inhibit rna targets in different tissues without the need for complex delivery vehicles .
roche has agreed to acquire santaris pharma , a pioneer in the emerging era of rna - targeting therapeutics via its proprietary locked nucleic acid ( lna ) platform . the acquisition , which is subject to customary closing conditions , is expected to close in august 2014 . roche plans to maintain santaris pharma’s operations in denmark , where the existing site will be renamed roche innovation center copenhagen . under the terms of the agreement , roche will make an upfront cash payment of usd 250 million to santaris pharma shareholders and make additional contingent payments of up to usd 200 million based on the achievement of certain predetermined milestones .
law360 , los angeles ( february 27 , 2014 , 8 : 24 pm est ) - - a california federal judge on thursday refused to let santaris pharma a / s corp . off the hook in isis pharmaceuticals inc . ' s infringement suit accusing santaris of leveraging isis ' patented drug discovery development platform to sign multimillion - dollar development deals , saying santaris isn’t protected by a safe harbor statute .
we are delighted that isarna therapeutics selected santaris pharma as its partner , further validating that our lna drug platform is the technology - of - choice for developing rna - targeted medicines ,
said dr .
roche ( six : ro , rog ; otcqx : rhhby ) announced today that it has agreed to acquire santaris pharma , a privately held biopharmaceutical company based near copenhagen , denmark . santaris pharma has pioneered its proprietary locked nucleic acid ( lna ) platform that has contributed to an emerging era of rna - targeting therapeutics . this new class of medicines has the potential to address difficult to treat diseases in a range of therapeutic areas .
, chief scientific officer and vp business development of santaris pharma .
this deal is yet another example of our intention to add more alliances with biotechnology companies such as isarna therapeutics to our growing list of partners .
the acquisition , which is subject to customary closing conditions , is expected to close in august 2014 . roche plans to maintain santaris pharma’s operations in denmark , where the existing site will be renamed roche innovation center copenhagen .
new york , may 1 ( genomeweb news ) - danish drug developer santaris pharma said today that it has created a microrna research consortium in partnership with the department for medical biochemistry and genetics at the university of copenhagen .
santaris pharma a / s has substantial intellectual property rights that includes ownership of more than 60 patent families which cover the lna chemistry , manufacturing , therapeutic uses in patients and animals and optimal drug designs and drug formats .
miragen is using santaris ' lna technology to develop mirna - targeted therapies . miragen has a deal with
to spearhead the us expansion , santaris pharma a / s has appointed leading rna industry expert arthur a . levin , phd , as president of its us operations . in addition , dr . levin will hold global responsibility as vice president and chief development officer of santaris pharma a / s . dr . levin has 15 years of experience in rna - based research and more than 25 years of experience in the pharmaceutical industry . prior to joining santaris pharma a / s , dr . levin was senior vice president of drug development at isis pharmaceuticals where he was instrumental in advancing more than a dozen rna - based antisense drugs from basic research to clinical development .
announcing the alliance , president and ceo of santaris pharma , dr . don debethizy , said :
we are delighted that roche has deepened its commitment to the field of oligonucleotide therapeutics and we are obviously proud and honored that they have chosen santaris as their partner . this is a very important deal to santaris and we look forward to working closely with the roche teams in our joint pursuit of novel , breakthrough drugs .
santaris pharma is a clinical - stage biopharmaceutical company focused on developing a new class of drugs intended to switch off the expression of harmful genes . called rna antagonists , these new drugs are being developed by santaris and its corporate partners for the treatment of cancer and metabolic disorders . created in may 2003 and backed by a broad group of leading international life science venture capital investors , santaris pharma completed a euro 40m second round of equity financing in may 2006 . in july 2006 , the company entered into a global partnership with enzon pharmaceuticals of new jersey to co - develop and commercialise a series of santaris rna antagonists for improving the treatment of cancer .
the expansion of our collaboration with santaris pharma a / s demonstrates our strategic intention to partner with innovative biopharm / biotech companies to explore novel drug design technologies as a potential source for breakthrough therapeutics ,
said mikael dolsten , president of worldwide research and development at pfizer .
we have been encouraged by the progress of our oligonucleotide collaboration with santaris pharma and are eager to explore this expanded partnership for potential additional lna - based drug projects .
hoersholm , denmark and san diego , jan . 4 , 2011 / prnewswire / — santaris pharma a / s , a clinical - stage biopharmaceutical company focused on the research and development of mrna and microrna targeted therapies , and pfizer inc . ( nyse : pfe ) , today announced that the companies have expanded their collaboration directed to the development and commercialization of rna - targeted medicines using santaris pharma a / s locked nucleic acid ( lna ) drug platform .
the expansion of our collaboration with santaris pharma a / s demonstrates our strategic intention to partner with innovative biopharm / biotech companies to explore novel drug design technologies as a potential source for breakthrough therapeutics ,
said mikael dolsten , president of worldwide research and development at pfizer . he added ,
we have been encouraged by the progress of our oligonucleotide collaboration with santaris pharma and are eager to explore this expanded partnership for potential additional lna - based drug projects .
according to maraganore , “in the 2005–2009 period , big pharma made big bets on rnai technology platforms . unfortunately , some of the big pharma technology efforts have not been so successful , at least as measured by ind filings , of which there are none . ”
he added , “the santaris investment story exemplifies forbion’s ability to select new potential disruptive platform technologies at an early stage , which drive a clear medical break - through . this deal for santaris further extends forbion’s solid track record . ”
santaris pharma a / s is a privately - held biopharmaceutical company focused on developing rna - based drugs targeted to disease - related mrnas and micrornas . utilizing the company’s proprietary locked nucleic acid ( lna ) drug platform and drug discovery engine , santaris pharma a / s provides fast and efficient generation of lead lna drug candidates . the company’s own research and development activities focus on infectious diseases and metabolic disorders while partnerships with major pharmaceutical companies include a range of therapeutic areas including cancer , rare genetic disorders and inflammatory diseases . santaris pharma a / s , founded in 2003 , is headquartered in denmark with operations in the us . the company has strategic partnerships with enzon pharmaceuticals , glaxosmithkline , wyeth pharmaceuticals and shire plc . please visit urltoken for more information .
international biopharmaceutical company focused on the discovery and development of rna - targeted therapies for a range of diseases including metabolic disorders , infectious and inflammatory diseases , cancer and rare genetic disorders . ( prnewsfoto / santaris pharma a / s ) ( prnewsfoto / )
ørum declined to say how much money his company was spending to license the drug from roche . the tavistock group did not respond to a request for comment . ørum was a longtime executive at santaris pharma , which was acquired by roche in 2014 .
unlike isis’ more recent big pharma deals with j & j , gsk , biogenidec , and astrazeneca , however , i expect this to involve less early development work by isis as some of this would be the obvious job of the former santaris crew .
roche completed its acquisition of partner santaris for $ 250 million in cash up front and up to $ 200 million in undisclosed milestones . in january , santaris and roche partnered to discover and develop rna - targeted drugs against . . .
roche will acquire partner santaris for $ 250 million in cash up front and up to $ 200 million in undisclosed milestones . santaris is using its locked nucleic acid ( lna ) platform to develop antisense drug candidates . lead . . .
“forbion recognized that santaris’ lna chemistries were the best in class antisense technology when the firm led the recapitalization of the company in 2006 , ” said martien van osch , managing partner at forbion and board member of santaris pharma . “forbion has been a strong proponent of the company ever since , working closely with the management to promote the significant therapeutic potential of this new class of drugs .
increasing interest , new collaborations and breakthrough advancements utilizing the company’s proprietary rna - based locked nucleic acid ( lna ) drug platform and drug discovery engine led santaris pharma a / s , headquartered in denmark , to establish us - based operations in san diego , california .
in 2011 , the swiss pharma giant sold its rna interference ( rnai ) pipeline , delivery technologies and research facility to arrowhead research corporation exiting .
santaris will receive an upfront payment and is eligible for development , regulatory and sales milestones . furthermore , santaris will receive a share of any sub - licensing revenues and royalties on worldwide sales of alliance products . no further financial details have been disclosed .
to wit , in 2011 isis sued santaris for infringing its rnaseh gapmer patents by santaris signing on big pharma partners regarding rnaseh therapeutics development . isis viewed this as a form of monetizing their ip and consequently sued . if decided in isis’ favor , the case would have been a notable departure from the long - held practice of shielding preclinical business and drug development under the safe harbor of the research exemption .
/ prnewswire / - - santaris pharma a / s and betaisarna therapeutics gmbh announced today that they have signed an agreement whereby isarna gains access to santaris ' locked nucleic acid ( lna ) technology to further develop its next generation oligonucleotide product candidates . under the terms of the agreement , isarna obtains rights to utilize santaris pharma ' s proprietary lna drug platform to discover , develop and commercialize immunotherapeutics targeted against the cytokine transforming growth factor beta1 , beta2 and beta3 ( tgf - beta ) . tgf - beta represents a critical pathway in oncology as its overexpression has been linked to progression and poor patient outcomes for various cancers and is suspected to play a role in other diseases as well .
we are confident that the unique features of the lna drug platform can achieve clinical breakthroughs and look forward to working closely with the bristol - myers squibb team ,
henrik oerum , ph . d . , santaris pharma ' s cso and vp , business development commented .
roche innovation center copenhagen a / s is the home of rna therapeutics research ( rtr ) for roche pharma research and early development ( pred ) .
“pharma is becoming more modality agnostic instead of just summarily dismissing oligos as drugs . they are primarily now just looking at these agents as drugs . ”
over the now several decades–long history of nucleic acid therapeutics , big pharma has had an on - again , off - again relationship with the technology .
in october of this year , merck said it was restructuring r & d . the pharma did not say whether cuts will include its rnai platform .
/ prnewswire / - - santaris pharma a / s and rana therapeutics , inc . announced today that they have signed an agreement whereby rana gains access to santaris ' locked nucleic acid ( lna ) technology to develop rna - targeted medicines . under the terms of the agreement , santaris will license its proprietary locked nucleic acid drug technology to rana for the development of lna - based drug candidates against up to 10 rana proprietary rna targets . the license granted by santaris includes access to proprietary chemistry capable of delivering potent single - stranded lna - based drug compounds . rana will apply the lna chemistry along with its proprietary technologies for selective protein activation to develop rna - targeted medicines . santaris will receive an upfront payment and is eligible for target nomination payments , development milestones and royalties on each product .
santaris pharma a / s recently achieved a breakthrough in medical science as the first company to advance a microrna - targeted therapy into human clinical trials . a single - dose phase 1 trial in healthy volunteers has now been completed and an additional phase 1 multiple ascending - dose study is planned . the drug spc3649 specifically targets microrna - 122 ( mir - 122 ) , a host factor for hepatitis c virus replication . in 2008 , santaris pharma a / s published the results of successful microrna silencing with spc3649 in non - human primates in nature [ 1 ] .
new york ( genomeweb ) — isis pharmaceuticals and santaris pharma are currently negotiating a settlement to their roughly three - year - old patent - infringement lawsuit and believe there is
strong potential to settle
the litigation instead of going to trial , according to court documents filed this month .
wyeth has made an upfront payment of $ 7m in cash and a $ 10m equity investment in santaris . a further $ 83m may be paid in milestone payments for each of 10 potential targets . santaris will also receive worldwide royalties from products that reach the market .
last month , santaris pharma a / s announced a multi - year worldwide strategic alliance with shire plc to discover and develop new rna - based medicines to treat rare genetic disorders utilizing santaris pharma’s proprietary lna drug platform . this collaboration adds to the growing list of mrna and microrna drug discovery and development partnerships , which includes wyeth ( delivery of lead candidates against up to ten targets ) , glaxosmithkline ( four viral disease drug candidates ) and enzon pharmaceuticals ( eight cancer targets successfully delivered ) . operations in the us aim to support existing relationships and generate new licensing and partnership opportunities .
, cso & vp business development of santaris pharma a / s , said
santaris pharma ' s lna drug platform provides the means to discover and develop novel drugs that potently and specifically bind rna - targets in previously inaccessible clinical pathways . usually , the objective is to inhibit the target to avoid protein synthesis , but in rana ' s case the lna drugs will be developed to selectively activate protein expression . as such , our agreement with rana is yet another example of how we seek to leverage the broad applicability of our drug platform through partnerships with the pharmaceutical industry .
by way of background , isis sued santaris ( a danish corporation not to be confused with isis’s fellow san diego - based firm santarus , recently bought by salix pharmaceuticals ) , accusing santaris of infringing isis patents to antisense compounds and methods of making the antisense compounds when santaris contracted to sell antisense drug discovery services and products to four pharmaceutical company customers in the united states . santaris moved for summary judgment on its affirmative defense that the alleged acts of infringement fell within the safe harbor provision of 35 u . s . c . § 271 .
the court denied santaris’s summary judgment motion , finding that santaris failed to provide undisputed evidence of the belief that the merck i court found was needed to properly claim the 271 ( e ) ( 1 ) safe harbor ( see above quote ) . instead , the isis court stressed that santaris’s supporting declaration by one of its officers provided only a general description of the collaborations between santaris and its customers . this , the court found , did not provide any detailed analysis of santaris’s uses of the allegedly infringing compounds , methods and processes to establish they rose to the level of a reasonable belief , as contemplated by merck i , as to a patented compound’s way of achieving a particular biological effect and , thus , failed to show that santaris fell under the protection of the 271 ( e ) ( 1 ) safe harbor .
micrornas are a newly discovered class of small regulatory molecules which control many biological processes in cells . in addition , micrornas are implicated in many diseases , such as cancer , viral infections , cardiovascular disease and neurological disorders and , therefore , represent a new class of targets for therapeutic intervention . santaris pharma
micrornas are a newly discovered class of small regulatory molecules which control many biological processes in cells . in addition , micrornas have been implicated in many diseases , such as cancer , viral infections , cardiovascular disease and neurological disorders and , therefore , represent a new class of targets for therapeutic intervention . santaris pharma
the agreement will see roche make an upfront cash payment of $ 250m to santaris shareholders and then further , conditional , milestone payments of up to $ 200m . the deal is expected to close later this month , when santaris ' danish operations will become the roche innovation center copenhagen .
santaris has developed its own flavor of antisense called locked nucleic acid technology , which the company claims is more effective in neutralizing targeted rna sequences .
according to krieg , “pharma is becoming more modality agnostic instead of just summarily dismissing oligos as drugs . they are primarily now just looking at these agents as drugs . ”
this gives the therapeutic increased potency , resistance to degradation , a long half life and ensures it is readily taken up by tissues , according to santaris .
santaris is based in denmark and performs research in san diego . it is unrelated to san diego - based santarus , which makes drugs for gastrointestinal ailments .
santaris pharma announced that it has commenced a phase i human volunteer trial of spc3649 ( lna - antimirtm - 122 ) , the world ' s first microrna medicine to be tested in man , according to the company . the study is being conducted by phaseonetrials a / s , copenhagen , and will include a maximum of 48 . . .
what to look for : new collaborations are in the works . phase ii data will be a major milestone for santaris as it advances a variety of trials .
commenting on its acquisition by roche , santaris ' president and ceo j . donald debethizy said the companies had complementary capabilities that will help them “realise breakthrough medicines” .
the drug produced only mild side effects , said michael r . hodges , vice president and chief medical officer of santaris , the study ' s senior author .
santaris pharma announced that it has commenced a phase i human volunteer trial of spc3649 ( lna - antimirtm - 122 ) , the world ' s first microrna medicine to be tested in man , according to the company . the study is being conducted by phaseonetrials a / s , copenhagen , and will include a maximum of 48 . . . more
“these study results are the culmination of over 6 years of microrna research at santaris pharma a / s , ” said michael r . hodges , md , vice president and chief medical officer at santaris pharma a / s . “the results of this study highlight miravirsen’s exceptional high barrier to resistance , long duration of action and good tolerability . miravirsen would be especially suitable for treatment of hard - to - treat patients , for example those patients who have already failed treatment with pegylated - interferon and ribavirin combination or protease inhibitor triple therapy . ” dr . hodges continued , “longer treatment durations of miravirsen are currently being tested in clinical trials in subjects who have failed initial therapy for hcv infection . ”
john reed , head of roche pharma research and early development , said :
today there are many disease targets that are very challenging or even impossible to reach with small molecules or antibodies .
two years after pfizer ( $ pfe ) inherited wyeth ' s discovery pact with denmark ' s santaris , its researchers have decided to significantly up the ante on their deal . the pharma giant is handing over $ 14 million in an upfront fee and promising up to $ 600 million more in milestones to expand the deal to develop rna - targeted drugs .
the lna drug platform and drug discovery engine developed by santaris pharma combines the company ' s lna chemistry with its targeted drug development capabilities to deliver lna - based drug candidates against rna targets , both mrna and microrna , for a range of diseases including infectious and inflammatory diseases , cardiometabolic disorders , cancer , and rare genetic disorders . the lna drug platform , according to santaris , overcomes the limitations of earlier antisense and sirna technologies to deliver potent single - stranded lna - based drug candidates across a multitude of disease states .
under the terms of the partnership the two companies will collaborate on the discovery , development and commercialisation of new medicines using santaris’ locked nucleic acid ( lna ) drug platform .
santaris claim that “ lna is the first true three - dimensional analogue of rna ” , which can be incorporated into oligonucleotides to enhance binding affinity to complementary rna sequences .
at least seven companies developing oligonucleotide - based drugs have licensed the technology from or partnered with santaris , which has an internal pipeline of six antisense molecules in the clinic .
maraganore agreed . “rnai therapeutics partnerships will be focused on product alliances . pharma has recently grown their interest in the rna therapeutics space but with an interest in products , not technology , ” he said .
“the acquisition of santaris provides roche the unique opportunity to merge their deep expertise in disease biology , target selection , toxicology , formulation , and drug delivery with the most extensive experience in designing and producing lna oligonucleotides , a technology that roche believes will redefine rna - targeting medicine in the future , ”  a santaris spokesperson told in - pharmatechnologist . com .
the acquisition marks an acceleration in roche ' s interest in both rnai research and santaris , after the two companies struck a more limited $ 148m discovery and development deal in january .
the court also cited the santaris officer’s previous statement to the pto that , “ ( t ) he majority of [ santaris ' s ] collaborators have taken broad licenses to our proprietary lna platform in order to discover , develop , and commercialize new lna - based drugs against rna targets associated with disease , ” observing that the reference to selling “platform” technology so that another company could develop and discover drug candidates , suggested that santaris was using its technology for “basic research” not covered under the § 271 ( e ) ( 1 ) safe harbor .
santaris was the first company to bring a mirna - targeting molecule into the clinic . the company ' s miravirsen , an lna - modified anti - mirna that targets hepatocyte mir - 122 , is in phase ii testing to treat hcv . in 2013 , santaris published phase iia data showing that miravirsen resulted in a dose - dependent reduction in hcv rna levels . 8
santaris claims its lna platform enables specific targeting and regulation of micrornas ( mirnas ) and messenger rnas ( mrnas ) , which is an area wyeth has been making efforts to establish itself in .
naarden , the netherlands - 4 august 2014 - forbion capital partners , the leading dutch vc firm investing in world - class healthcare technologies announces the sale of its portfolio company , santaris pharma a / s for a total consideration of up to $ 450 million , of which an upfront cash payment of $ 250 million and additional contingent payments of up to $ 200 million based on the achievement of certain predetermined milestones .
s proprietary lna drug chemistry and the screening platform will be developed by a collaborative research consortium led by santaris pharma and the biotech research & innovation centre ( bric ) at the university of copenhagen . other members of the consortium are the nucleic acid centre ( nac ) , university of southern denmark , h . lundbeck a / s , the danish headquartered pharmaceutical company and ribotask a / s , the danish reagents company .
hoersholm , denmark / san diego , california — santaris pharma a / s , a privately - held biopharmaceutical company focused on developing rna - based drugs targeted to disease - related mrnas and micrornas , today announced it has established operations in the united states . internally and through its partners , the company has a robust drug development pipeline including programs to treat metabolic disorders , infectious and inflammatory diseases , cancer and rare genetic disorders .
developed using santaris pharma a / s proprietary locked nucleic acid ( lna ) drug platform , miravirsen is an inhibitor of mir - 122 , a liver specific microrna that the hepatitis c virus requires for replication . miravirsen is designed to recognize and sequester mir - 122 , making it unavailable to the hepatitis c virus . as a result , the replication of the virus is effectively inhibited and the level of hepatitis c virus is profoundly reduced .
santaris got $ 17 million in cash and equity from wyeth for their original pact struck in early 2009 . the revised deal includes potential royalty payments for drugs promising to hit up to 10 rna targets .
nevertheless , although accepting some of santaris’s legal arguments , the isis court cited santaris’s failure to provide undisputed evidence of such knowledge or belief in denying santaris’s summary judgment motion . the court found instead that fact issues remained as to whether santaris ' s collaboration agreements were
reasonably related
to the type of information submitted to the fda—that is , whether it was
objectively reasonable for a party in [ santaris ' s ] . . . situation to believe that there was a decent prospect that the accused activities would contribute , relatively directly , to the generation of the kinds of information that are likely to be relevant in the processes by which the fda would decide whether to approve the product in question
[ citing merck i , 545 u . s . at 200 - 01 ( district court jury instruction ) ] . accordingly , the court found that this fact question regarding what was reasonable , should be left to the trier of fact , as is customary for most questions involving a question of what is reasonable .
called miravirsen , the drug reduced the virus by a factor of 100 to 1 , 000 in the phase 2a trial , santaris said . study results were published wednesday in the new england journal of medicine .
the swiss company , which exited the rnai field in 2010 as part of an r & d restructure , believes santaris ' rna - targeting technology could underpin the discovery and development of a new class of medicines .
santaris ' pipeline of rnai - or ' gene silencing ' - drugs are based on its locked nucleic acid ( lna ) platform and its lead candidate is miravirasen , a novel hepatitis c treatment in phase ii trials .
, ceo of isarna therapeutics said :
in optimizing our cancer immunotherapeutics , we see santaris ' lna approach as a unique enabling technology to support the efficacy profile of our novel products targeted at breakthrough status diseases .
under the agreement of the transaction , roche will make an upfront payment of $ 250 million in cash to santaris’ shareholders as well as up to $ 250 million in additional contingent payments once specific predetermined milestones are met .
every drug is targeted at a precise rna sequence in messenger or microrna ,
says mccullagh . for mccullagh , the whole field offers an opportunity that can one day rival monoclonal antibodies . and that message has not been lost in the pharma world .
shire’s business development and licensing team scooped the award , this year for the pace and strength of its activities , including the acquisition of viropharma ( jan 2014 ; $ 4 . 2bn ) , lumena pharmaceuticals ( may 2014 ; $ 260m ) and fibrotech ( may 2014 , $ 75m ) . its portfolio was expanded by licencing agt - 182 from armagen ( jul 2104 ; $ 225m ) and rebalanced by selling distribution rights for estrace to trimel pharma ( july 2014 ; $ 41m ) and dermagraft to organogenesis ( jan 2014 ; $ 300m ) . partnerships were also inked with prasco labs ( fosrenol distribution ; oct 2013 ) , santaris pharma ( lna drugs ; aug 2013 ) and argen - x ( drug discovery partnership ; june 2014 ) .
such therapies offer a number of benefits over traditional small molecule and monoclonal antibody approaches , according to santaris , including reducing candidate failure due to pharmacokinetic / toxicology predictability , and increased chemistry , manufacturing and control ( cmc ) efficiency .
dr . john reed , head of pharma research and early development ( pred ) at roche stated :
we are very pleased with our new partnership with santaris . we believe the lna drug platform provides the means to discover novel drugs against a range of targets of high clinical relevance that are difficult – or impossible - to target with other drug platforms . as such , the partnership will increase our ability to discover and develop important novel medicines that can address significant unmet needs in critical therapeutic areas
.
exiqon’s product offering includes lna™ amidites and lna™ oligonucleotides for the research and development of pharmaceutical products . exiqon has the exclusive right to supply such products except for use in the research and development of pharmaceutical products containing lna™ as the active ingredient . today’s decision by the arbitration court establishes exiqon’s non - exclusive right to supply these products also for the research and development of pharmaceutical products containing lna™ as the active ingredient . santaris pharma’s request that exiqon should be prevented from supplying lna™ products for such use was dismissed .
) . the positive rulings by the united states patent and trademark office ( uspto ) cover two key santaris pharma a / s
imanishi
patents , u . s . pat . no . 6 , 268 , 490 ( the
' 490 patent
) and u . s . pat . no . 6 , 770 , 748 , ( the
' 748 patent
) , which claim rights to the locked nucleic acid ( lna ) or bicyclic nucleic acid ( bna ) chemical structure used for developing antisense molecules .
the united states patent and trademark office ( uspto ) revoked the ex parte re - examination of the ' 490 patent and provided a notice of intent to issue a reexamination certificate that confirms the patentability of all claims of the ' 490 patent owned by santaris pharma a / s and is not subject to appeal . in addition , the uspto issued an action closing prosecution in the inter - partes re - examination of ' 748 patent , which is a continuation - in - part of the ‟490 patent , confirming all of the original claims .
the expanded alliance with pfizer is a result of our successful collaboration over the last two years and provides further evidence that our lna drug platform is rapidly becoming the technology - of - choice for partners interested in developing rna - targeted medicines ,
said soeren tulstrup , president and ceo of santaris pharma a / s .
the lna drug platform is well positioned to deliver viable drug candidates today , and we are excited to expand our relationship with pfizer to pursue our goal of making rna - targeted drugs for important diseases a reality .
santaris pharma a / s lna drug platform combines the company ' s proprietary lna chemistry with its highly specialized and targeted drug development capabilities to rapidly deliver potent single - stranded lna - based drug candidates across a multitude of disease states including infectious and inflammatory diseases , cardiometabolic disorders , cancer , and rare genetic disorders . the unique combination of pharmaceutical properties , small size and very high affinity of lna - based drugs allows this new class of antisense drugs to potently and specifically inhibit rna - targets in many different tissues without the need for complex delivery vehicles .
this written announcement contains forward - looking statements , identified by the use of words such as
believes ,
expects ,
may ,
will ,
should
,
potential ,
anticipates ,
plans
or
intends
and similar expressions . such forward - looking statements involve risks , uncertainties and other factors that may cause actual results , events or developments to be materially different from the future results , events or developments indicated in this announcement . such factors include , but are not limited to the timing , success and cost of clinical studies ; the ability to obtain regulatory approval of products , market acceptance of and future demand for santaris pharma products and the impact of competitive products and pricing . these factors should be considered carefully and readers are cautioned not to place undue reliance on such forward - looking statements . no assurance can be given that the future results covered by the forward - looking statements will be achieved . all information in this press release is as of the date of this press release and santaris pharma does not intend to update this information .
one of the major challenges facing oligonucleotide therapeutics is the effective and broad delivery to target tissues . in the field of sirna therapeutics , both chemical modification and liposomal formulation are being widely explored as means to overcome this challenge . in this presentation , santaris pharma researchers show that in preclinical models short , single stranded lna oligonucleotides can be administered intravenously as naked molecules and are broadly taken up by a wide range of targeted tissues ( e . g . , kidney , liver , bone marrow , spleen , intestine , skin , lymph nodes , and pancreas ) .
in a comment , president and ceo of exiqon , lars kongsbak said : “ exiqon is committed to provide best in class products for the detection of nucleic acids using our lna™ technology . this has allowed us to become a leader in our markets , and serves as the foundation for exiqon’s commitment to develop , and help propel the development of , novel molecular diagnostic products , including companion diagnostics , for which we provide easy access to our proprietary technologies through licensing . proceedings against santaris pharma were an unfortunate , but necessary , step towards realizing our business goals . ”
fda - regulated firms - - drug , device , biologic or otherwise - - on both sides of the patent aisle concerned with the bounds of the “safe harbor” exception to patent infringement under 35 u . s . c . § 271 ( e ) ( 1 ) can learn several key lessons from the recent decision in isis pharmaceuticals , inc . v santaris pharma a / s corp . ( hereafter : “ isis ” ) , particularly how to properly prove the safe harbor defense once the litigation unfolds and also when the harbor provides shelter from post - approval patent storms .
the scoop : santaris has been breaking new ground with its advancement of a microrna therapy into the clinic in late may . a successful proof - of - concept trial for hepatitis c is being billed as a potential medical breakthrough , offering a key to modulating networks of genes .


the anthony and allison sirna studio is a historic artist 's studio at 60 way # 4 in wellfleet , massachusetts .

it is one of a modest number of surviving buildings in wellfleet that combine elements of modern architecture with traditional cape cod architecture .

the studio was built in 1960 to a design by victor civkin ; it has a trapezoidal plan with nine large vertical window bays .

the building is within the bounds of the cape cod national seashore , and is owned by the national park service .

anthony and allison sirna studio

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the sima studio is eligible for individual listing in the national register of historic places under criterion a at the local level and criterion c at the state level for its associations with the development of recreational residences , cultivation of a progressive social network , and dissemination of modem style architecture on outer cape cod during the midtwentieth century . the building possesses significance under criterion a in the areas of recreation and social history for its associations with the postwar , progressive , intellectual community that commissioned the construction of singlefamily , modem style vacation houses in the underdeveloped peripheries of the outer cape towns . under criterion c , the building possesses significance in the area of architecture as a distinctive representation of accomplished eastern european emigre architect victor civkin ' s residential designs during the last decade of his career . civkin influenced domestic design throughout the united states during his tenure as general electric ' s chief architect and through his completion of approximately 500 private residential commissions . the sima studio is a rare example of his limited work in massachusetts and is one of six known residences he designed in the state .
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the national register of historic places is the official list of the nation ' s historic places worthy of preservation . authorized by the national historic preservation act of 1966 , the national park service ' s national register of historic places is part of a national program to coordinate and support public and private efforts to identify , evaluate , and protect america ' s historic and archeological resources .
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the house was listed on the national register of historic places in 2014 . [ 1 ]
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once picturesque cottages , these now - defunct hovels owned by the seashore are rotting in plain sight on the cape .
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