ionis pharmaceuticals ( nasdaq : ions ) ( known as isis pharmeceuticals until december 2015 ) is a publicly traded pharmaceutical company based in carlsbad , california , united states .

the company was founded in 1989 by stanley crooke , a former glaxosmithkline head of research , with a goal to commercialize antisense therapy .

the company received its first fda approval for an investigational new drug application in 1992 , marking the first time any antisense drug was approved to be tested in humans ; the ind was for isis ' genital warts drug candidate .

the company and others founded to bring antisense drugs to market faced early failures ; isis ' lead compound for genital warts failed in clinical trials and isis terminated development in 1995 ; by that time two other companies working on antisense , gilead sciences and genta had left the field , leaving isis , hybridon , and lynx therapeutics working in the field .

gilead sold the patents it had developed around antisense to isis .

in december 2015 isis changed its name to ionis , driven in part by the negative image of " isis " generated by the terrorist group , islamic state of iraq and the levant , commonly known as isil or isis .

ionis pharmaceuticals

ionis pharmaceuticals™ is a trademark of ionis pharmaceuticals , inc . akcea therapeutics™ is a trademark of ionis pharmaceuticals , inc .
see what the ihs markit score report has to say about ionis pharmaceuticals inc .
here ' s why the best is yet to come for ionis pharmaceuticals , inc .
ionis pharmaceuticals revises 2015 financial guidance and provides pipeline update in conjunction with j . p . morgan conference
, the company changed its name from isis pharmaceuticals , inc . to ionis pharmaceuticals , inc . in this press release , unless the context requires otherwise ,
ionis ,
company ,
we ,
our ,
and
us
refers to ionis pharmaceuticals and its subsidiaries .
here ' s why the best is yet to come for ionis pharmaceuticals , inc . - - the motley fool
, chief financial officer of ionis pharmaceuticals .
we expect to end 2015 with a pro forma nol in the low
brian orelli has no position in any stocks mentioned . the motley fool owns shares of and recommends alnylam pharmaceuticals , biogen , and ionis pharmaceuticals . the motley fool has a disclosure policy .
ptc therapeutics spiked wednesday after an analyst suggested it and roche could rout biogen and ionis pharmaceuticals in treating spinal muscular atrophy .
here ' s why the best is yet to come for ionis pharmaceuticals , inc . @ themotleyfool # stocks $ ions , $ nvs
the companies , alnylam pharmaceuticals and isis pharmaceuticals , expect to announce today an equally owned joint venture to develop drugs that work by blocking so - called micro - rnas .
there ' s also ionis education group based in paris ; the ionis art hotel on the island of zakynthos , greece ; and ionis international , provider of pacific rim intercultural business training programs .
isis pharmaceuticals has changed its name to ionis pharmaceuticals , the carlsbad biotech company announced friday . with the new name - - free of any similarities to the widely used acronym for the islamic state terrorist group , comes a new stock ticker - - ions .
brian orelli has no position in any stocks mentioned . the motley fool owns shares of and recommends biogen and ionis pharmaceuticals . the motley fool has a disclosure policy .
kastle therapeutics has acquired global rights to develop and commercialize the marketed drug kynamro ® ( mipomersen sodium ) injection from ionis pharmaceuticals for up to $ 95 million - plus .
brian orelli has no position in any stocks mentioned . the motley fool owns shares of and recommends ionis pharmaceuticals and johnson & johnson . the motley fool has a disclosure policy .
the companies had partnered on nusinersen for sma— one of several collaborations by the companies —since 2012 , when ionis was known as isis pharmaceuticals and the sma candidate was called isis - smn rx .
ionis pharmaceuticals ( ions ) has developed many drugs for the treatment of various life - threatening diseases through its broadly applicable drug discovery platform . as mentioned in the previous part , ionis’s revenue grew 24 . 7 % yoy ( year - over - year ) in q1 2018 . the chart below shows ionis’s revenue since q1 2017 , and analysts’ estimate for q2 2018 .
ionis pharmaceuticals ( ions ) , an rna1 - targeted therapeutics development leader , commercializes products in collaboration with other pharmaceutical companies . in q1 2018 , ionis’s revenue grew 24 . 7 % yoy ( year - over - year ) to $ 144 . 4 million from $ 115 . 8 million .
ionis - dmpk - 2 . 5rx was being tested in myotonic dystrophy type 1 , which is caused by the toxic dmpk rna . like most of ionis ' drugs , ionis - dmpk - 2 . 5rx was designed to bind to the rna and degrade it . while ionis and its partner biogen saw some signs that the drug was working , it wasn ' t enough to justify taking ionis - dmpk - 2 . 5rx further into development .
several cure sma grants totaling over $ 500 , 000 were given to dr . ravi singh while at u massachusetts , to help develop the intellectual property needed to investigate asos for sma . the intellectual property generated with our funding was then licensed to ionis pharmaceuticals for an sma drug called spinraza ( originally called ionis - smnrx , then nusinersen ) . ionis partnered with biogen to continue developing this drug .
about ionis pharmaceuticals , inc . ionis is the leading company in rna - targeted drug discovery and development focused on developing drugs for patients who have the highest unmet medical needs , such as those patients with severe and rare diseases . using its proprietary antisense technology , ionis has created a large pipeline of first - in - class or best - in - class drugs , with over a dozen drugs in mid - to late - stage development . drugs currently in phase 3 development include volanesorsen , a drug ionis is developing and plans to commercialize through its wholly owned subsidiary , akcea therapeutics , to treat patients with familial chylomicronemia syndrome and familial partial lipodystrophy ; ionis - ttr rx , a drug ionis is developing with gsk to treat patients with all forms of ttr amyloidosis ; and nusinersen , a drug ionis is developing with biogen to treat infants and children with spinal muscular atrophy . ionis ' patents provide strong and extensive protection for its drugs and technology . additional information about ionis is available at urltoken .
biogen has exercised its option to develop and commercialize nusinersen following positive interim phase iii results , agreeing to advance the spinal muscular atrophy ( sma ) candidate in a deal that could generate $ 225 million - plus for ionis pharmaceuticals .
in 2015 , ionis added nine new drugs to its pipeline . already in 2016 , the company has added two new drugs to its pipeline : ionis - biib5 rx and ionis - biib6 rx . both new drugs are being developed together with biogen and are designed to address undisclosed targets for the treatment of patients with neurodegenerative diseases . ionis currently has a total of 38 drugs in its pipeline .
carlsbad , calif . , june 18 , 2018 / prnewswire / - - ionis pharmaceuticals , inc . ( ions ) today announced that damien mcdevitt , ph . d . has joined the company as chief business officer . just this year , ionis has seen its first commercial drug for a neurological disease , spinraza , reach blockbuster status .
biogen ( biib ) completed a pact to collaborate with ionis pharmaceuticals ( ions ) , and bought 11 . 5 million ionis shares for $ 625 million , paying $ 54 . 34 each . biogen also invested $ 375 million as an upfront payment to ionis to
jointly discover and develop novel antisense drugs for a broad range of neurological diseases ,
as stated in a press release . in total , biogen laid out $ 1 billion in cash .
ionis—which changed its name in december 2015 from isis pharmaceuticals—had been seeking a commercialization alternative since january , when it terminated its license agreement with sanofi , a genzyme company , to co - market kynamro : “we’ve been disappointed with the performance of genzyme for quite a while , ” ionis cbo sarah boyce told the san diego union - tribune at the time .
as discussed earlier , ionis pharmaceuticals’ ( ions ) revenue grew 24 . 7 % yoy ( year - over - year ) in q1 2018 , and analysts expect it to grow 30 . 6 % yoy to $ 136 . 0 million in q2 2018 . the graph below shows ionis’s commercial and r & d ( research and development ) revenue since q1 2017 .
mid - caps stocks , like ionis pharmaceuticals inc ( nasdaq : ions ) with a market capitalization of us $ 5 . 85b , aren’t the focus of most investors who prefer to direct their investments towards either large - cap or small - capread more . . .
the rest of the revenue came from the usual mix of milestone payments and licensing fees from ionis ' various partners .
in addition , ionis announced that results from the phase 1 / 2 study with ionis - ar - 2 . 5 rx in heavily pretreated , late - stage prostate cancer patients demonstrated encouraging data , including several durable reductions in psa levels . the drug also exhibited a good safety and tolerability profile supportive of continued development . data from this study will be presented later in the year . ionis plans to continue the development of ionis - ar - 2 . 5 rx independent of astrazeneca .
the deal marks kastle’s first acquisition since it was formed last year . kastle focuses on acquiring , developing , and commercializing pharmaceuticals targeted toward diseases with high unmet medical needs .
nusinersen is the first antisense drug from ionis’ neurological disease franchise to advance to regulatory review : “it illustrates the potential of our antisense technology to address severe diseases that other therapeutic modalities are unable to address adequately , ” added ionis coo b . lynne parshall .
however , the name has been used in other contexts . ionis is
a level 53 npc ,
( non - player character ) according to a world of warcraft fan page . and in another fantasy game , final fantasy xi , ionis is a beneficial magic spell .
next up in the late - stage pipeline , investors will get to see data from ionis - ttrrx , which treats familial amyloid polyneuropathy , sometime this quarter . assuming the data from the phase 3 trial are positive , ionis - ttrrx should be able to get onto the market soon after volanesorsen . positive data could also convince ionis ' marketing partner , glaxosmithkline , to test the drug against the cardiomyopathy version of the disease .
biogen has paid ionis a $ 75 million license fee after exercising its option to develop and commercialize nusinersen globally . biogen is now responsible for all nusinersen development , regulatory and commercialization activities , and costs , while ionis will complete the phase iii studies and work with biogen on regulatory filings .
basel , january 06 , 2017 - novartis announced today a collaboration and option agreement with ionis pharmaceuticals , inc . and its affiliate akcea therapeutics , inc . , to license two novel treatments with the potential to significantly reduce cardiovascular risk in patients suffering from high levels of lipoproteins known as lp ( a ) and apociii . the two investigational antisense therapies developed by ionis - called akcea - apo ( a ) - l rx and akcea - apociii - l rx - have the potential to lower both lipoproteins up to 90 % and significantly reduce cardiovascular risk in high - risk patient populations . in addition novartis entered into a stock purchase agreement with ionis .
carlsbad , calif . , june 5 , 2018 / prnewswire / - - ionis pharmaceuticals , inc . ( ions ) announced today that it closed its expanded strategic collaboration with biogen ( biib ) to discover and develop novel antisense drugs for a broad range of neurological diseases following receipt of clearance under the hart - scott - rodino ( hsr ) antitrust improvements act of 1976 . biogen paid ionis $ 1 billion in cash , which included $ 625 million for the purchase of 11 , 501 , 153 shares of ionis common stock at a price of $ 54 . 34 per share and a $ 375 million upfront payment . on april 20 , 2018 , ionis and biogen announced they would expand their strategic collaboration to develop novel antisense drugs for a broad range of neurological diseases through a new ten - year collaboration .
kastle agreed to pay ionis $ 15 million upfront , another $ 10 million due may 3 , 2019 , and up to $ 70 million in payments tied to achieving sales milestones . beginning in 2017 , kastle will pay ionis royalties on global sales of kynamro in the mid to low teen percentage range .
the new technology has gotten the backing of ionis ' partners . astrazeneca and johnson & johnson are developing drugs with ionis that use the combination of both technologies . bayer recently exercised its option to develop a lica - based drug and the aforementioned deal with novartis was for lica - based drugs as well .
these drugs work through the antisense technology pioneered by ionis . this technology blocks diseases at the genetic level , by blocking or changing the production of proteins .
and ionis recently got approved for spinal muscular atrophy , side effects aren ' t an issue because there aren ' t any other treatment options at the moment .
a decade of improvements , modifications , and collaboration with antisense therapeutics company isis ( now ionis ) pharmaceuticals resulted in the development of nusinersen—a drug delivered via spinal injection that is expected to become the first therapeutic for sma . in august , ionis halted its phase 3 trial in sma patients after interim analyses showed that infants receiving a spinal injection of nusinersen were better able to kick , stand , and walk than infants undergoing a sham procedure . “obviously , we’re extremely excited , ” says krainer . “it’s sort of beyond anyone’s most optimistic expectations . ”
however , 3 % of the cash payments that ionis receives from kastle—up to $ 2 . 85 million—plus a 3 % royalty on kynamro sales—will be earned by genzyme .
ionis recently announced plans to spin off its cardiovascular drugs , including volanesorsen and the novartis - partnered drugs , into a separate company called akcea . ionis will get royalties ranging from the mid - teens to the mid - 20s on the drug as well as a 50 % cut of the milestone payments and royalties from the novartis partnership .
the two companies said they will also work together to transition the clinical programs that ionis is conducting to biogen . in addition to the license fee , ionis could receive tiered royalties on potential sales of nusineren up to a percentage in the mid - teens , in addition to up to $ 150 million in milestone payments based on regulatory approvals .
for isis pharmaceuticals , a name change was not in consideration as recently as last year . but a company spokesman told cbs news this week that the tragedy “weighed heavily on us , and we don’t want to have that association . ”
and volanesorsen . any statement describing ionis ' goals , expectations , financial or other projections , intentions or beliefs is a forward - looking statement and should be considered an at - risk statement . such statements are subject to certain risks and uncertainties , particularly those inherent in the process of discovering , developing and commercializing drugs that are safe and effective for use as human therapeutics , and in the endeavor of building a business around such drugs . ionis ' forward - looking statements also involve assumptions that , if they never materialize or prove correct , could cause its results to differ materially from those expressed or implied by such forward - looking statements . although ionis ' forward - looking statements reflect the good faith judgment of its management , these statements are based only on facts and factors currently known by ionis . as a result , you are cautioned not to rely on these forward - looking statements . these and other risks concerning ionis ' programs are described in additional detail in ionis ' annual report on form 10 - k for the year ended
“the promise is already here , ” john rossi , an rna biologist and cofounder of dicerna pharmaceuticals , wrote in an email to the scientist , adding that he sees “the next few years as becoming the era [ of oligonucleotide therapeutics ] . ”
it seemed to me that everybody came together and decided that ionis was a nice - sounding , feeling name , as soon as someone hit on it ,
crooke said .
in july , but it still owns 70 % of the shares after the ipo , so ionis will have to incorporate ackcea ' s financials into its own for the foreseeable future .
ionis has two drugs on the market , two more in late - stage development , and a large number of phase 2 drugs that could have proof of concept data shortly . to pay for those clinical trials , ionis phamraceuitcals has partnered many of its drugs while keeping some of the ones for smaller orphan indications where smaller clinical trials can be run relatively cheaply .
alnylam seemingly outperformed rival ionis in tests of drugs to treat a progressive rare disease , an analyst said thursday . both biotech companies are making treatments for a condition known as hereditary attr amyloidosis .
since we know the antisense technology works , it ' s likely that the issue is that ionis - dmpk - 2 . 5rx isn ' t getting into the muscles , where the toxic rna lies . as noted on the slide , ionis and biogen are exploring a ligand conjugated antisense ( lica ) strategy to target a drug directly to the muscle , which should increase the potency .
in related chmp news , the committee also advised against approval of vanda pharmaceuticals ' ( $ vnda ) fanaptum for treating schizophrenia , with the chmp raising concerns about evidence of marginal efficacy of the drug compared with placebo in studies and heart risks associated with the treatment .
ionis ' newest drugs use generation 2 . 5 chemistry that can provide up to a 10 - fold increase in potency over the generation 2 . 0 version . ionis has also developed a ligand - conjugated antisense ( lica ) technology that can target drugs to specific tissue . the combination of generation 2 . 5 and lica makes for very potent drugs , which can decrease doses and reduce side effects .
ionis still has five unpartnered drugs in its pipeline that it could license to generate more cash and has plans to add three to five drugs this year ( although some of those drugs could already be partnered under research collaborations with partners ) . and , to top it off , royalties income will ramp up as the launch of spinraza continues and volanesorsen and ionis - ttrrx are hopefully launched in the years to come .
over the years - - many , many years - - ionis has improved the technology to increase the drugs ' potency through increasing the binding of the drug to the rna and by decreasing degradation of the drug .
ionis is an empty vessel name , crooke said , without any inherent meaning other than what is created by what the company does . patent and other checks indicated that the name was free of legal problems or unwanted associations .
amazingly , despite having about two dozen drugs in the clinic and essentially no royalties from drugs yet , ionis was able to cover all of its expenses through up - front and milestone payments from partners during the fourth quarter .
stanley crooke , the ceo of ionis , is bluntly enthusiastic . “the babies [ with the severest disease ] are alive and the longer we treat the better they seem to get , ” he says . “it’s a miracle . ”
as discussed previously , analysts expect ionis pharmaceuticals’ ( ions ) revenue to grow yoy ( year - over - year ) in 30 . 6 % yoy to $ 136 . 0 million in q2 2018 . they expect the company to report an adjusted net loss of $ 24 . 3 million due to higher sg & a ( selling , general , and administrative ) and r & d ( research and development ) expenses , resulting in a loss per share of $ 0 . 09 . the chart below shows analysts’ recommendations for pfizer stock over the last 12 months .
companies called isis have been forced to confront how attached they are to the name . isis was once the name of a mobile payment technology and a new condo building in florida . they both changed their names last year . isis pharmaceuticals , a california biotech company founded in 1989 , told cnn it is now discussing the same move .
while that ' s fine for clinical trials , it may make it difficult for ionis ' drugs to compete with drugs that work as well but don ' t have side effects that need to be monitored . of course , for spinraza , which
the technologies are more similar than they are different , notes c . frank bennett , senior vice president of research at isis pharmaceuticals .
at the end of the day , they ' re both catalytic mechanisms and antisense mechanisms , in that the antisense strand is what binds to the target and causes cleavage of the message ,
he says .
despite considerable progress in oligonucleotide delivery , clinical successes have been balanced with setbacks that serve as reminders that the path to commercialization is never guaranteed . in august , for example , biopharmaceutical company and ionis partner oncogenex announced that its antisense drug custirsen failed to improve survival of patients with prostate cancer in late - stage clinical trials . and earlier this year , ionis reported dangerous reductions in platelets among patients in phase 3 trials for two unconjugated antisense therapies , one for a rare cardiac condition , and one for elevated triglycerides . although most drugs in ionis’s pipeline are now conjugated , which the company hopes will avoid such side effects , the announcement triggered a 40 percent plunge in share prices in may . ( shares are now recovering as the company makes progress with nusinersen . )
ionis is built on a platform technology called antisense where the drug binds to a specific rna and , for most of the drugs , signal for their degradation . lower levels of the rna results in lower levels of the disease - causing protein the rna codes for .
akcea therapeutics , inc . ( akca ) , an affiliate of ionis pharmaceuticals , inc . , focused on developing and commercializing drugs to treat people with serious and rare diseases , today announced completion of a new study to assess the burden of people living with familial chylomicronemia syndrome ( fcs ) and its impact on their daily lives . results from the study known as re - focus were published on june 11 , 2018 in the peer - reviewed journal expert review of cardiovascular therapy . the web - based global study was conducted among people with fcs treated with volanesorsen , akcea’s investigational therapy currently under regulatory review in the us , eu and canada .
akcea therapeutics , inc . ( akca ) , an affiliate of ionis pharmaceuticals , inc . , focused on developing and commercializing drugs to treat people with serious and rare diseases , today announced completion of a new study to assess the burden of people living with familial chylomicronemia syndrome ( fcs ) and its impact on their daily lives . results from the study known as re - focus were published on june 11 , 2018 in the peer - reviewed journal expert review of cardiovascular therapy . the web - based global study was conducted among people with fcs treated with volanesorsen , akcea ` s investigational therapy currently under regulatory review in the us , eu and canada .
but it wasn ' t just the unsavory association that caused isis to become ionis , ( pronounced “eye - oh - nis
) said stanley t . crooke , the company ' s chairman and chief executive . it was the potential problems the confusion could cause for isis employees .
that pipeline contains dozens of medicines for severe or rare diseases such as various cancers , diabetes , spinal muscular atrophy and cardiovascular diseases . the phase 3 drugs are nusinersen , for spinal muscular atrophy ; volanesorsen , for high triglycerides ; and ionis - ttrrx , for ttr cardiomyopathy amyloidosis .
last may , ionis announced that it had discovered cases of thrombocytopenia - - low blood platelet levels - - in patients taking two of its drugs . the clinical trial protocols were amended to increase testing of platelet levels , which has eliminated the occurrence of
serious platelet events .
the main difference between the two approaches is that the mechanism of first - and second - generation oligonucleotide - based drugs is fairly well - characterized , whereas rnai is still in its early days . in fact , alnylam pharmaceuticals , a leader in rnai , only recently showed that short interfering rnas could have a systemic effect , a feat achieved long ago by earlier generations of antisense molecules .
reported $ 203 million in sales of their spinal muscular atrophy drug , spinraza , during its second full year on the market , netting ionis $ 22 . 4 million in royalties on sales of the drug . the royalties are tiered and should increase as a percentage of sales as spinraza sales increase .
more recently , alnylam has conjugated its sirnas to the sugar molecule n - acetylgalactosamine ( galnac ) to give the drugs even greater affinity for hepatocytes , improve potency , and reduce off - target effects . early - stage testing of fitusiran , a galnac - conjugated sirna targeting a liver - produced protein associated with hemophilia , is ongoing , the company says . meanwhile , ionis has already adopted a similar method to conjugate galnac with antisense oligonucleotides destined for the liver—an advance that ionis claims improves delivery and provides a more than 30 - fold increase in potency over unconjugated approaches currently in trials . rnai company arrowhead pharmaceuticals is also using galnac to help deliver oligonucleotides to the liver , but instead of conjugating it directly to the sirna , the company’s dynamic polyconjugate ( dpc ) technology links the sugar to the sirna via a polymer that helps protect the cargo until it enters a cell . a recent clinical study on hepatitis b therapeutic arc - 520 found that the drug inhibits the production of viral protein in infected patients by up to 99 percent after a single dose .
on a rocky road toward hoped - for approvals , sanofi ' s ( $ sny ) mipomersen has hit a serious rut with european regulators . a european medicines agency panel handed down a negative opinion late this week on the antisense drug from isis pharmaceuticals ( $ isis ) for treating a genetic disease that causes blood cholesterol to jump , citing safety concerns such as signs of liver toxicity and cardiovascular risks in patients in clinical trials .
it took several glancing blows and one heck of a sucker punch to fully shake the confidence of the investment community in oligonucleotide - based antisense therapeutics . a major hit came as early as 1998 , when gilead sciences , a pioneer in the antisense space , abandoned the technology after its gene - code - blocking development pact with glaxo wellcome fell apart . gilead subsequently sold its antisense patent estate , which had been more than a decade in the making , to isis pharmaceuticals .
even with a relatively small number of patients , ionis was able to show beyond any doubt that volanesorsen could reduce triglyceride levels better than the placebo . sure , management is gloating a little , listing all of those zeros after the decimal point , but it has a right to be excited about the data - - and volanesorsen ' s potential .
participants enrolled in the sham - controlled arm of embrace , a phase ii study that also included infantile - onset patients , will have the opportunity to receive nusinersen , biogen and ionis said . other studies in the nusinersen program , including cherish ( later - onset consistent with type 2 ) and nurture ( presymptomatic infants ) , will continue as planned .
, chief operating officer at ionis .
we have also demonstrated in 2015 that the advances we are making in our technology continue to make better and better medicines , which allows us to expand the application of our drugs to new tissues , new targets and new diseases . all of this sets us up for an exciting and event - filled 2016 .
ionis ' antisense technology is currently the most effective way to inhibit synthesis of both lipoproteins in the liver , according to data published in the lancet [ 1 ] . the galnac3 - conjugated antisense oligonucleotide technology is 30 times more potent than the parent antisense oligonucleotide , leading to a lower dose and the potential for highly effective therapeutic targeting and much improved tolerability .
on the basis of those findings , biogen and ionis said , the endear study will be stopped and participants will be able to join the shine open - label study in which all patients receive nusinersen . data from the other endpoints of endear will be analyzed when the full data set is available , with results to be presented at future medical congresses , the companies said .
the arrival of vitravene , a short strand of 21 dna molecular units that blocks viral replication , was hailed as a major milestone for the biotech industry and was widely anticipated to usher in a new era of antisense products . but no more came . and by the middle of the last decade , isis pharmaceuticals , the carlsbad , california–based company behind vitravene , ended up pulling the therapy from the market because improvements in other antiretrovirals had effectively eliminated the drug’s target market . boni’s cautionary words proved all too prescient .
sanofi ' s genzyme unit , leading the regulatory charge for mipomersen , which the company hopes to market under the name kynamro , plans to request the ema give its application another look through a re - examination process . yet the fortunes of the program appear to be waning with every safety red flag reviewers have raised about the drug . and aegerion pharmaceuticals ( $ aegr ) has a rival oral therapy for the same disease that has already gained wider support from the fda panel that narrowly recommended approval of mipomersen months ago .
researchers , pharmaceutical companies , and investors now anxiously await results from several late - stage trials , anticipated in 2017 , as well as nusinersen’s approval , for confirmation that oligonucleotide therapeutics are finally reaching maturity . “every year it seems like we’ve gotten closer , ” says phillip zamore , director of the rna institute at the university of massachusetts school of medicine and cofounder of rnai therapeutics company alnylam pharmaceuticals . even rnai drugs , which joined the game later than antisense , are catching up , he adds . “now there are phase 3 clinical trials . ”
it appears from the phase 3 data that volanesorsen should be able to get approved . it ' s not a perfect drug - - it has some side effects - - but the risk - benefit profile looks strong enough to gain approval , especially given the unmet need in patients with rare diseases - - familial partial lipodystrophy and familial chylomicronemia syndrome - - that cause severely high triglyceride levels , which ionis is going after .
in 2003 , adrian krainer and his postdoctoral colleague luca cartegni , biochemists at the cold sping harbor laboratory in new york , engineered a synthetic , rna - like molecule that in the test tube changed how the transcripts from smn2 are spliced into the mature messenger rnas that then are translated into protein—in principle , this could boost production of the normal , full - length smn protein . three thousand miles away , at isis—now renamed ionis—a scientist named frank bennett noticed the work , published in nature structural biology , and called krainer . the spinal muscular atrophy foundation provided funding for krainer to hire researcher yimin hua . hua’s extensive work in krainer’s lab , in collaboration with ionis , led to the identification and preclinical development of nusinersen , a snippet of modified rna called an antisense oligonucleotide that intervenes in the splicing process to ensure that smn2 expresses the full - length smn protein .
even with the inevitable failures , ionis has plenty of additional drug candidates to take their place . check out the chart in the lower right ; that ' s a list of drugs expected to enter the clinic in the next 18 months . it ' s hard to read the details , but it ' s the volume of drug candidates , not necessarily what diseases the new crop of drugs will treat , that investors should be excited about .
in may , the company reported positive results for its neuro - ttr phase 3 trial testing inotersen in patients with hereditary ttr amyloidosis . glaxosmithkline handed back rights to the drug , but this may be a it ' s - not - you - it ' s - me kind of breakup , since glaxosmithkline is undergoing a strategic review of its assets . ionis is shooting to file marketing applications for inotersen in the u . s . and eu by the end of the year .
while that ' s good news , and ionis has next - generation technologies that are even more potent - - generation 2 - plus - - where it thinks the lower doses aren ' t causing thrombocytopenia side effects , the lack of serious events doesn ' t mean the current late - stage drugs aren ' t reducing platelet levels ; it ' s just that patients with low - but - not - serious platelet levels can be taken off the drug , avoiding major problems .
novartis is building a robust cardiovascular portfolio of targeted therapies to address unmet medical need of high - risk patients ,
said vasant narasimhan , global head , drug development and chief medical officer , novartis .
lp ( a ) and apociii are potent , genetically validated cardiovascular risk reduction targets . the importance of predictive biomarkers in achieving successful cardiovascular outcomes will also be essential in the future payer environment . we look forward to working with ionis and akcea to develop both treatments .
although just published in the lancet , those findings have since been overtaken by strikingly positive results from the larger phase iii trials . in their november announcement about the second trial’s halt , ionis and biogen , which has licensed nusinersen and has dubbed it spinraza , said the treated children experienced a “highly statistically significant improvement” in motor function compared to untreated children . the companies had used an established , widely used test of motor movements that monitors actions like sitting , standing , putting the hands on the head and taking steps .
after extensive preclinical development and testing , the drug began trials in sma patients in late 2011 . in a phase ii trial described in the lancet today , ionis and academic collaborators report that it extended the life spans and improved the motor function of babies with severe sma , compared with the disease courses in natural history studies of untreated babies . to receive nusinersen , the babies had to have developed sma symptoms between 3 weeks and 6 months of age ; the drug was injected into the cerebrospinal fluid surrounding the spinal cord .
while ionis ' approved drugs and those in phase 3 development will dictate the biotech ' s near - term future , long - term results will come from the success of its next - generation technologies . adding lica to the molecules as well as chemistry changes in the structure between generation 2 - plus and generation 2 . 5 lower the effective dose required to treat 50 % of the population ( ed50 ) . with increased potency will hopefully come decreased side effects and the ability to target new diseases in different parts of the body .
about novartis novartis provides innovative healthcare solutions that address the evolving needs of patients and societies . headquartered in basel , switzerland , novartis offers a diversified portfolio to best meet these needs : innovative medicines , eye care and cost - saving generic pharmaceuticals . novartis is the only global company with leading positions in these areas . in 2015 , the group achieved net sales of usd 49 . 4 billion , while r & d throughout the group amounted to approximately usd 8 . 9 billion ( usd 8 . 7 billion excluding impairment and amortization charges ) . novartis group companies employ approximately 118 , 000 full - time - equivalent associates . novartis products are available in more than 180 countries around the world . for more information , please visit urltoken .
“these [ infant - onset ] sma kids are going to die . and not only are they now not dying , you are essentially on the path to a true cure of a degenerative [ neurological ] disease , which is unheard of , ” says jeffrey rothstein , a neurologist at the johns hopkins school of medicine in baltimore , maryland , who was not affiliated with the trials of the drug and is not connected with either of the two companies involved in its development : ionis of carlsbad , california , and biogen of cambridge , massachusetts .
consequently , most oligonucleotide therapeutics companies have focused on the liver . ionis has antisense oligonucleotide therapeutics in more than 10 clinical trials targeting diseases in the organ , from thrombosis to hepatocellular carcinoma . and alnylam’s most advanced therapeutic is an intravenous , nanoparticle - carried drug called patisiran , an rnai treatment that knocks down the translation of a mutated protein made in the livers of patients with a rare disease called hereditary amyloidosis . results from phase 3 trials of the drug are expected in 2017 and , if successful , could pave the way for the first approval of an rnai therapeutic .
pipeline update ionis management will present an update today on its drug development pipeline at the j . p . morgan conference , including an update on its ongoing open - label phase 2 clinical study of nusinersen in infants with type i spinal muscular atrophy ( sma ) . previously the company reported data from this study on event - free survival , measures of muscle function and assessments of developmental milestones . the data reported today show continued increases in median event - free survival and muscle function scores . the safety and tolerability profile of nusinersen to date continues to support further development .
here , we present retrospective and prospective examples of how early analysis of headroom may aid in decisions along a translational continuum . the first example illustrates the need for analysis of future market prospects—technologies may fail close to clinical adoption if the expected health benefit shrinks at the time of market entry . vitravene ( fomivirsen ) , an antisense therapy developed at the national institutes of health and licensed by isis pharmaceuticals , inc , was approved by the fda in august 1998 to treat cytomegalovirus retinitis ( cmv - r ) . during its development in the 1990s , aids had transformed cmv - r from a rare disease into one of the most common ocular infections in the united states . when approved for use , vitravene was a biomedical breakthrough as the first fda - approved antisense therapy . while vitravene was in phase 3 clinical trials , highly active anti - retroviral therapy ( haart ) regimen , the “3 - drug cocktail” , was developed to suppress hiv replication and allow the immune system to recover . as a consequence , the number of new cases of cmv - r declined by nearly 75 % . when vitravene reached the market , distributed by novartis ophthalmics ag , haart had been standard therapy for about a year . new cases of cmv - r were less common , and many existing cases no longer needed treatment ; in other words , the health crisis that vitravene was designed to address had receded and sales of the product were much lower than predicted . as a result , novartis no longer markets vitravene , but isis pharmaceuticals still cites vitravene as evidence of its “ability to meet fda and european regulatory requirements for safety and efficacy , and for the commercial manufacture of antisense drugs . ”
although targeting other tissues is challenging , some companies are now making strides to do just that . ionis , for example , has developed modified antisense oligonucleotides that show effective targeting to cells in the kidney . arrowhead , meanwhile , is working on dpcs that will target cells in non - liver tissues such as tumors by incorporating ligands that target cell type–specific surface proteins . “it’s a matter of finding the right receptor - ligand combinations and to figure out how to conjugate the proper ligands , ” explains krainer . “down the line , i think one could have a set of conjugates that would allow you to target particular organs . ”
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mipomersen , to which sanofi gained rights through its 2011 buyout of genzyme , narrowly passed muster with an fda panel in october with a rems plan to track the safety of the therapy in patients taking it for the genetic disease , homozygous familial hypercholesterolaemia ( hofh ) . the ema ' s committee for medicinal products for human use ( chmp ) , however ,
was not convinced that the company had proposed sufficient measures to prevent the risk of irreversible liver damage ,
the ema stated in a document .
we are disappointed by the committee ' s recommendation . patients with hofh carry extreme , ongoing cardiovascular risk with significantly elevated ldl - c levels despite use of currently available therapies ,
said david meeker , president and ceo , genzyme .
this is a rare disease patient population , with a life - threatening condition , in need of new therapies . we will work closely with the chmp during the re - examination process to address the committee ' s concerns , with the goal of making this important medication available to hofh patients in europe .
isis certainly has a lot riding on mipomersen too , as the company has been prolific in securing partnerships , notably with with biogen idec ( $ biib ) and astrazeneca ( $ azn ) , and slow to advance its antisense therapies to the market .
the european commission gets the final say on drug approvals and often follows the advice of the chmp .
sanofi ' s cholesterol drug shot down by ema . is aegerion ' s lomitapide a better bet for approval ? with input from @ ryanmfierce
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two biotechnology companies are joining forces in commercial pursuit of an emerging scientific field that could lead to treatments for numerous diseases .
micro - rnas , virtually unheard of a few years ago , are tiny snippets of rna — the chemical cousin of the genetic material dna — that have been found to play a major role in controlling biological processes . scientists have identified about 500 different micro - rnas that are made by human cells , and these snippets in turn appear to influence the activity of thousands of genes .
studies have already linked micro - rnas to cancer , viral infections , immune disorders and other diseases . so blocking specific micro - rnas — or perhaps stimulating them — could theoretically provide a powerful way to treat diseases .
“it’s as if we’ve discovered a new kingdom of regulation in biological metabolism that we didn’t know was there , ” said david baltimore , a nobel laureate and the president emeritus of the california institute of technology , who will be a director of the new company as well as chairman of its scientific advisory board .
the new company , called regulus therapeutics , will be equally owned by isis and alnylam but will have its own management and board . the management team has not been identified yet .
both alnylam and isis are pioneers in developing drugs that are made of rna and seek to suppress particular genes . the companies hope that combining their skills — and their patents — will allow them to dominate the micro - rna therapeutics business .
“this is the first time i’ve seen a biological advance as broad as this where the intellectual property is as concentrated in a single company as with regulus , ” said stanley crooke , chief executive of isis .
other companies are also starting to focus on micro - rna . one is rosetta genomics , an israeli company that is already collaborating with isis .
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so far , however , rna - related drugs have been difficult to develop . isis , based in carlsbad , calif . , has had many setbacks developing drugs using a technology called antisense . but its stock has nearly doubled in the last year on hopes for a drug that has sharply lowered cholesterol in clinical trials .
alnylam , based in cambridge , mass . , is trying to develop drugs that turn off specific genes by harnessing a natural phenomenon called rna interference . two of the discoverers of the phenomenon were awarded the nobel prize last year .
micro - rnas are related to rna interference . but john maraganore , chief executive of alnylam , said that while his company aims to shut off specific genes , regulus might be able to inactivate entire networks of genes . the broader effect , he conceded , could raise the risk of side effects .
to block a micro - rna , regulus will probably use the antisense approach — synthesizing short strands of an rna - like molecule that would bind to the micro - rna and inactivate it .
both companies are contributing intellectual property rights to regulus . alnylam is also contributing $ 10 million , since it has fewer patents to offer .
after this agreement , the companies will fund the venture equally . mr . crooke said that regulus , which is likely to be based in the san diego area , is expected to have about 20 people employed next year and to spend up to $ 20 million over its first two years . regulus has no drugs in clinical trials yet .
victor ambros , a professor at dartmouth who in the early 1990s discovered the first micro - rna , in the roundworm , said it was exciting to see companies being formed . “there’s a lot of excitement , and i think justifiably so , for the prospect of targeting the micro - rnas , ” said professor ambros , who has no ties to the companies .
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the owners of a bookstore in colorado that was vandalized earlier this week want the islamic state to be referred to as daesh .
a woman’s facebook account was disabled . a bookstore was vandalized . and one company , moved by the attacks on paris , just doesn’t want the association anymore .
while the name isis has become synonymous with a terrorist organization , the islamic state of iraq and syria , it is also the name of a well - known egyptian goddess .
many women are named isis , including 396 babies born in the united states last year .
for the world’s many isises , each act of horror carried out by the islamic state has been accompanied by the unsettling and repeated use of their name in news reports . an online petitioner has even gathered almost 57 , 000 supporters to call on the news media to stop using the acronym .
“i named my daughter isis because it’s strong and meaningful , ” wrote one commenter on the petition , shani allman of florida . “to have it degraded and have her jeopardized by the media’s insensitivity is completely disturbing . ”
a woman in britain wrote that her 7 - year - old daughter , who was named after the goddess , went to bed crying “because people were being horrible to her about her name . ”
part of the river thames in britain remains known by the name , as does a feminist club at fordham university and the labrador in “downton abbey . ” the dog has been killed off from the show — though not because of its name . the cartoon “archer” also had to adjust the name of its spy agency . ( fans of comics and 1970s television may recall isis as the name of a superhero . )


ups airlines is an american cargo airline owned by united parcel service inc. ( nyse : ups ) .

the company is headquartered in louisville , kentucky .

its international all-points air hub , worldport , is based at louisville international airport .

the pilots are represented by the independent pilots association .

ups airlines

glassdoor has 29 ups airlines reviews submitted anonymously by ups airlines employees . read employee reviews and ratings on glassdoor to decide if ups airlines is right for you .
select an airline airbridge cargo air china british airways cargolux airlines china airlines china southern airlines eva airways finnair cargo japan airlines international co . , ltd . malaysia airlines ups parcel delivery service ltd . virgin atlantic airway
handling airline airbridge cargo air china hactl . britishairways cargolux airlines china airlines china southern airlines eva airways finnair cargo japan airlines international co . , ltd . malaysia airlines ups parcel delivery service ltd . virgin atlantic airway
glassdoor gives you an inside look at what it ' s like to work at ups airlines , including salaries , reviews , office photos , and more . this is the ups airlines company profile . all content is posted anonymously by employees working at ups airlines .
ups on twitter :
ups airlines has over 200 browntails in our fleet with close to 2000 daily flights . # upslaunch urltoken
ups airlines has over 200 browntails in our fleet with close to 2000 daily flights . # upslaunch urltoken
providing the latest news and info on ups airlines , worldport , and ups’s global air network . questions about a package ? just ask @ upshelp .
s7 airlines ( siberia airlines ) airbus a321 - 211 vq - bqj ( msn 2076 ) muc ( arnd wolf ) . image : 941037 .
copyright photo : ups airlines ( ups - worldwide services ) boeing 747 - 8f n609up ( msn 64254 ) pae ( nick dean ) . image : 941249 .
copyright photo : ups airlines ( ups - worldwide services ) boeing 747 - 8f n609up ( msn 64254 ) pae ( nick dean ) . image : 941250 .
copyright photo : ups airlines ( ups - worldwide services ) boeing 747 - 8f n607up ( msn 64265 ) pae ( nick dean ) . image : 939436 .
copyright photo : ups airlines ( ups - worldwide services ) boeing 747 - 8f n607up ( msn 64265 ) pae ( nick dean ) . image : 939437 .
ups airlines is adding the newer and larger boeing 747 - 8f intercontinental freighter to its boeing 747 - 400f freighter fleet .
a plan evolved to utilize the hub already established at louisville by ups for its second - day service , which used contract carriers including evergreen airlines , orion airways , ryan international , interstate airlines and ipx air . for a while , ups hired other airlines to fly planes owned by ups to provide next - day service . oehme says that as volume grew ,
it was becoming very difficult to coordinate four different airlines into one air operation .
the line - up of international airlines flying to the u . s . mainland will grow this winter . the latest to announce service is hong kong airlines .
i love the ethiad one . and the american airlines is a huge improvement .
2010 – the coalition for clean air recognized ups airlines with its 2010 california air quality award in the category of corporate leadership .
2006 – ceres , a non - governmental organization , included ups in its rating of global companies that strive to reduce greenhouse gas emissions . ups ranked first among the airlines rated .
cambodia may not be able to support more than four local airlines over the long term . the four existing airlines , none of which operate more than seven aircraft , lack the scale to compete effectively with foreign airlines , and the proposed start ups will face similar challenges if they succeed at launching services .
hong kong airlines to begin flying to u . s . mainland with new airbus a350s
at which ever blog does one see a reference to yemenia yemen airlines ? or hainan airlines ? love it ! you must really get around . or you’re very bored .
1998 – ups airlines , palm beach international ' s only all - cargo carrier , was recognized as one of five airlines to fly 100 percent takeoffs and landings in quieter stage 3 aircraft . the palm county board of county commissioners presented the quiet fleet award to ups .
“these aircraft are a strategic investment for increased capacity for ups customers around the globe , ” said brendan canavan , president , ups airlines . “the 747 - 8 will allow ups to upsize our network in both new and existing markets . ”
american and southwest airlines ( nyse : luv ) are the largest carriers at sky harbor .
cambodia is experiencing another surge of start up activity with several airlines seeking to commence operations . cambodia already has four local airlines , including two start ups from 2014 , despite a relatively small market consisting of approximately 7 million annual passengers .
i applied through other source . the process took 4 + weeks . i interviewed at ups airlines ( louisville , ky ) in june 2010 .
the chinese state - owned company will compete with chicago - based united continental holdings inc . , parent company of united airlines , and fort worth , texas - based american airlines group inc . , parent company of american airlines , whose commercial aircrafts are flying the same route .
hong kong airlines to begin flying to u . s . mainland with new airbus a350s the line - up of international airlines flying to the u . s . mainland will grow this winter . the latest to announce service is hong kong airlines . check out this story on urltoken urltoken
how much do ups airlines employees make ? glassdoor has salaries , wages , tips , bonuses , and hourly pay based upon employee reports and estimates .
american airlines has launched new international flights from its hubs in chicago and dallas - fort worth .
ups airlines is not alone in converting planes : lufthansa , aloha and alaska airlines , among others , yank the seats out of some of their passenger planes at night to fly a load of cargo . the overhead bins and ' ' passenger service units , ' ' with emergency oxygen and reading lights , are harder to install and remove , though , and only ups airlines does a full conversion .
“scale matters in this industry , ” said gordon m . bethune , the former chairman of continental airlines , who was widely credited for turning around that company’s fortunes in the 1990s . “how many airlines does france or germany have ? i mean , do we really need 19 domestic airlines in the united states ? i think three or four network airlines would still give you plenty of competition . ”
ups airlines strives to reduce its impact on the environment by operating the most fuel - efficient fleet in the package airline sector and aggressively managing aircraft and air hub operations . as the operator of one of the world ' s largest airlines , ups also leads the industry in deploying noise and emission reduction technologies .
ups is one of the lead airlines in developing and implementing data comm technology that replaces voice transmissions between the cockpit and air traffic control with text messaging .
ups airlines was founded in 1988 with seven leased boeing 727s , and for the next decade the plane remained the backbone of the shipping giant’s growing fleet .
“as we celebrate the 30th anniversary of ups airlines today , we are seeing unprecedented demand for our air products , ” said ups airlines president brendan canavan . “the new freighters will allow us to continue upsizing aircraft on routes and will create a cascading effect that will boost capacity on regional routes around the world . ”
an alaska airlines embraer e170 takes off over company metal at seattle tacoma international airport in may 2017 .
ups airlines was the fastest - growing airline in faa history , formed in little more than one year with all the necessary technology and support systems . today , ups airlines is one of the 10 largest airlines in the united states . ups airlines features some of the most advanced information systems in the world , like the computerised operations monitoring , planning and scheduling system ( compass ) , which provides information for flight planning , scheduling and load handling . the system , which can be used to plan optimum flight schedules up to six years in advance , is unique in the industry .
ups airlines flight landing hong kong international airport ( 想看更多影片記得訂閱 ) ups airlines flight 6 was a cargo flight operated by ups airlines . on september 3 , 2010 , a boeing 747 - 400f flying the route between dubai international airport and cologne bonn airport developed an in - flight fire , with the fumes and subsequent crash resulting in the death of the two crew members . [ 2 ] [ 3 ] the aircraft had departed dubai international earlier , but returned after reporting smoke in the cockpit . it was the first fatal air crash for ups airlines . [ 4 ] the crash caused an examination of safety procedures protecting airliners from cockpit smoke .
ups airlines flight 5x58 connects honolulu to hong kong , taking off from honolulu international airport ( hnl ) and landing at hong kong international airport ( hkg ) .
ups airlines was the fastest - growing airline in faa history , formed in little more than one year with all the necessary technology and support systems . today , ups airlines is one of the 10 largest airlines in the united states . ups airlines features some of the most advanced information systems in the world , like the computerized operations monitoring , planning and scheduling system ( compass ) , which provides information for flight planning , scheduling , and load handling . the system , which can be used to plan optimum flight schedules up to six years in advance , is unique in the industry .
ups and ups freight teamsters have approved giving their respective negotiating committees the right to call a strike , if necessary .
ups planes line up during night operations at ups worldport on the grounds of louisville international airport on dec . 12 .
but bigger has not quite turned out to be the cure - all . major airlines continue to lose huge sums of money . in the last decade , in fact , domestic airlines lost $ 60 billion .
the line - up of international airlines flying to the u . s . mainland will grow this winter .
777 compilation | los angeles [ klax ] | cathay pacific , japan airlines , air canada , etc .
ups ( nyse : ups ) announced today that it has named brendan canavan , a 33 - year ups veteran , the new president of ups airlines . canavan , 53 , replaces mitch nichols , who was promoted to senior vice president of transportation and engineering and named as a member of the company ' s management committee on june 12 , 2014 .
ups airlines flight 5x59 connects hong kong to anchorage , taking off from hong kong international airport ( hkg ) and landing at anchorage ted stevens international airport ( anc ) .
singapore airlines has long been one of the most highly recognized airlines , and its cargo division is no different . with dense operations throughout southeast asia , the company has expanded service in north america , europe and the middle east . singapore airlines cargo operates 13 boeing 747 planes , but no new orders are reportedly on the horizon .
hong kong airlines ' first airbus a350 makes its maiden flight at the airbus assembly line in toulouse , france .
ups airlines , and the company as a whole , are performing well . peak season , the month leading up to christmas , is the most critical time of year for us .
“someone awaiting a package in bangkok doesn’t care if it snowed in louisville , kentucky , ” said randy baker , a senior meteorologist for ups airlines . “they want their stuff . ”
he argued that airlines could benefit instead by expanding marketing tools like frequent - flier programs that foster loyalty from passengers .
the following cargo airlines operate out of john wayne airport . please visit their website for cargo drop - off locations .
royale airlines embraer emb - 110p1 bandeirante n692ra ( msn 110240 ) msy ( bruce drum ) . image : 104648 .
a passenger watches a united airlines airbus a320 pull into a gate at denver international airport on may 7 , 2017 .
an alaska airlines embraer e170 operated by affiliate skywest lands at seattle - tacoma international airport on may 18 , 2017 .
thank you for subscribing to receive email updates from ups . you have been added to the ups press release email distribution list and can expect to begin receiving ups news within 1 or 2 business days .
lithuanian airlines boeing 737 - 524 ly - agz ( msn 26340 ) cdg ( christian volpati ) . image : 941531 .
that eyeball searing yellow pustule inflicted on the skies by spirit airlines is too far in the opposite direction , of course .
david p . abney senior vice president and chief operating officer 56 senior vice president and chief operating officer ( 2007 – present ) , president , ups airlines ( 2007 – 2008 ) , senior vice president and president , ups international ( 2003 – 2007 ) .
the ups members authorized a strike , if necessary , by a 93 percent margin . at ups freight , the margin was 91 percent .
china airlines announced that free baggage allowances for all flights flown by its aircraft on asian , australia / new zealand and european routes will be increased by 10 kg from july 15 onwards . the move makes china airlines the first taiwan carrier to offer this privilege .
ups ( nyse : ups ) pilots represented by the independent pilots association today ratified a new labor agreement that becomes amendable sept . 1 , 2021 .
ii morrow inc . ; road net technologies inc . ; red arrow messenger service inc . ; ups properties inc . ; ups truck leasing inc .
using a battery - electric vehicle and drone from manufacturer workhorse , ups successfully tested a drone launched from the top of a ups package car recently .
the ups and world tails are not that bad and that simular in matter of copyright and design . i think airlines can protect a paint design , maybe ups did not protected the bowed line pattern , only their colours and logo . i ' m worrying more about those two :
contour airlines embraer erj 135er ( emb - 135er ) n16501 ( msn 145145 ) bwi ( brian mcdonough ) . image : 942603 .
at the same time , aviation experts predict china eastern’s new operation likely will take away big corporate clients from united and american airlines .
from etihad and iberia to spirit and southwest , several airlines have unveiled new looks . the report card is very , very bleak .
> the kindest thing that can be said about the spirit airlines > livery is that is should make search and rescue operations easier .
browntales is a show that goes behind - the - scenes of ups airlines . join host becca hunnicutt & tyler delawder as they take you on adventures throughout the world ' s largest package delivery company . # browntales
the overseas shipping war escalated as federal bought tiger international , inc . , a major international shipper that ups used for some of its foreign deliveries . ups
with growing demand for faster service , ups entered the overnight air delivery business , and by 1985 ups next day air service was available in all 48 states and puerto rico . alaska and hawaii were added later . that same year , ups entered a new era with international air package and document service , linking the us and six european nations . in 1988 , ups received authorisation from the federal aviation administration ( faa ) to operate its own aircraft , thereby officially becoming an airline . recruiting the best people available , ups merged a number of cultures and procedures into a seamless operation called ups airlines .
the demand for air parcel delivery increased in the 1980s , and federal deregulation of the airline industry created new opportunities for ups . but deregulation also caused change , as established airlines reduced flights and abandoned some routes altogether . to ensure dependability , ups began to assemble its own jet cargo fleet .
while the big network carriers struggled , low - cost airlines like southwest and jetblue have proved most nimble , posting consistent profits and grabbing market share . they may have started as bare bones , but the low - cost airlines now attract business travelers thanks to increasingly sophisticated networks .
sierra pacific airlines ( 3rd ) boeing 737 - 5l9 wl n709s ( msn 28722 ) bwi ( tony storck ) . image : 941354 .
mauritania airlines international boeing 737 - 8 max 8 5t - clj ( msn 64299 ) bru ( karl cornil ) . image : 941029 .
montenegro airlines fokker f . 28 mk . 4000 yu - aoi ( msn 11176 ) zrh ( rolf wallner ) . image : 941437 .
an alaska airlines boeing 737 taxies to the gate as a beautiful orange glow fills the sky at seattle tacoma international airport in may 2017 .
the kindest thing that can be said about the spirit airlines livery is that is should make search and rescue operations easier . ‘nough said .
when ups packages need to move faster than a delivery van can carry them , there ' s ups airlines . the air freight cargo unit of united parcel service operates a fleet of more than 500 aircraft , including more than 200 company - owned jets , known as browntails . the . . .
however , it is at 23 : 00 when the cgn hub really starts to gear up . this is when the flights begin arriving from ups’s outstations within its european network , as well as from the usa and asia . as with ups’s operations worldwide , the company’s european operations are flown by aircraft operated by its ups airlines division supplemented by a large fleet of chartered freighters .
ups ceo says $ 5 . 3 bln order for boeing 747 freighters reflects demand
. ups delivered any package meeting weight and size requirements to any location within 150 miles of these bases . after this initial expansion , ups frequently appeared before the
“this vote by our ups and ups freight members gives the negotiating committees bargaining leverage this week and during subsequent negotiations for the national contract and the supplements , ” said denis taylor , director of the teamsters package division and co - chairman of the teamsters national ups negotiating committee . “it is very helpful to have the members’ backing as we work toward negotiating strong contracts at ups and ups freight . ”
ups sorts millions of packages a day . here ' s what that looks like
you’ve served your country honorably . now take on your next challenge at ups .
the louisvillle international airport is home to the global operations center of ups worldport .
with growing demand for faster service , ups entered the overnight air delivery business , and by 1985 , ups next day air service was available in all 48 states and puerto rico . alaska and hawaii were added later . that same year , ups entered a new era with international air package and document service , linking the u . s . and six european nations . in 1988 , ups received authorization from the federal aviation administration ( faa ) to operate its own aircraft , thereby officially becoming an airline . recruiting the best people available , ups merged a number of cultures and procedures into a seamless operation called ups airlines .
in march 2003 , ups airlines implemented a fuel conservation program that saved more than 1 million gallons of fuel in its first year . savings are generated through the lido oc flight planning system , which was created by lufthansa . lido oc minimizes fuel burn by calculating the most efficient route between two points based on weather , winds , terrain and other factors . in addition to lido , ups airlines ramp procedures call for single engine jet taxiing whenever possible .
we are not owned by ups , we are our own airline which also owns north american airlines . ships 801de , 803de , and 804de are the delta birds which will be going to ups after our leases expire . 801 and 804 are in the standard all white livery , 803 has the heritage livery .
once the planes are delivered , ups will join two other cargo airlines as the world ' s second - largest operator of the 747 - 8 after lufthansa , germany ' s national carrier , which owns 19 for passenger service .
news of the l . a . route comes less than two months after hong kong airlines began flying from vancouver , its first north american destination .
s top ten airlines by virtue of its more than 500 company - owned and chartered aircraft . under the direction of ceo kent c . nelson in the late 1980s and early 1990s , ups strove mightily to maintain its dominant position in
most of u . p . s . ' s bigger planes lack windows , and even passenger doors . but ups airlines has 51 boeing 727 ' s with windows , plumbing and the other features that make them eligible for conversion .
track packages and find ups locations while you’re on the move with our mobile tools .
with investments like ups’s new 747 - 8 freighters , and a $ 2 billion capital investment underway in europe , ups is well - positioned for success in the future .
derrick mcdonald and carissa cox pack containers for the outbound flight cycle at ups worldport .
the airlines getting the favourable treatment , qantas , british airways and singapore airlines are allowed to land between 5am and 6am , the so - called shoulder period – because of the northern hemisphere summer and the curfews at airports including heathrow – even though those aircraft stop at other airports en route to sydney .
we are happy that our crewmembers have accepted this win - win contract offer , ” said brendan canavan , ups airlines president .
together , we have succeeded in taking care of both our people’s needs and our business objectives .
american airlines group inc . ( nasdaq : aal ) also has a hub at phoenix sky harbor international airport but does not have international flights from there .
which airlines are leading the consolidation of the industry and who are seeking , through that , a measure of stability and rationality . how do . . .
in hindsight , i realize i was confusing frontier with alaska airlines and the eskimo logo on the tail , so the harpoon imagery doesn’t make much sense .
ups is the world ' s largest package delivery company and a global leader in supply chain services , offering an extensive range of options for synchronizing the movement of goods , information and funds . headquartered in atlanta , ga . , ups serves more than 200 countries and territories worldwide . ups ' s stock trades on the new york stock exchange ( ups ) , and the company can be found on the web at ups . com .
fuel conservation long has been a priority at ups airlines . worldport , ups ' s all - points international air hub in louisville , was designed to reduce fuel consumption and emissions . aircraft park directly at the floor level of the facility , which significantly reduces the need to operate ground support equipment , reducing fuel use and emissions .
ups ( united parcel service ) ( ups airlines ) ( atlanta and louisville ) today announced second quarter 2015 diluted earnings per share of $ 1 . 35 , a 12 % increase over adjusted results for the same period last year . all three segments improved operating profit and margin , led by international and supply chain and freight performance .
united parcel service of america , inc . ; united parcel service general services co . ; united parcel service co . ; ups worldwide forwarding , inc . ; upico corporation ; ups capital corporation ; ups supply chain solutions , inc . ; ups re ltd . ( bermuda ) ; ups international , inc . ; united parcel service deutschland inc . ( germany ) ; c . c . & e . i , l . l . c .
turk hava yollari - turkish airlines douglas dc - 9 - 15 tc - jaa ( msn 47048 ) zrh ( jacques guillem collection ) . image : 941363 .
ups airlines also is the first u . s . - based carrier to use the lufthansa systems lido operations center , a computerized flight planning system that calculates the most efficient route between two points based on weather , winds , terrain and other factors .
ups ceo says $ 5 . 3 bln order for boeing 747 freighters reflects demand | reuters
aircraft for us delivery company ups crashes during emergency landing attempt , killing both crew members .
effective january 1 , 2017 , ups will require section ii batteries to be fully regulated .
stay up - to - date with the latest ups news , industry insights and more .
occupational safety rules at international airports however limit each piece of luggage to a maximum of 32 kg . those that exceed the limit will need to re - pack their luggage before check - in . for travelers whose check - in process involves other airlines stations , or those holding tickets from other airlines , the terms of their original ticket applies . the extra baggage allowances enjoyed by china airlines paragon , emerald and gold card members will remain unchanged . ( 2016 / 07 / 13 )
ups customers benefit from our ability to carefully manage and conserve fuel throughout the business , particularly when prices are surging ,
said ups airline and international operations vice president bob lekites .
we believe our customers recognize and appreciate ups ' s commitment to efficient operations .
ups customers benefit from our ability to carefully manage and conserve fuel throughout the business , particularly when prices are surging ,
said ups airline and international operations vice president bob lekites .
we believe our customers recognize and appreciate ups ' s commitment to efficient operations .
quoting mauriceb ( reply 3 ) : with that much airlines in the world , it would be rather hard for the airlines to all have a ' ' diferent style ' ' besides , with world , there is a white bar between the blue paint and the red bar , whyle ups doesn ' t have that . . . if it would be illegal , than ua and aeromexico would be wrong for exemple . .
- - having more ups airplanes use electrical power from buildings and in - ground electrical hook - ups instead of the aircraft ' s auxiliary power unit , which is powered by fuel .
there have been some glitches , but ups airlines has picked up all the accoutrements of an airline , right down to ticket jackets , emergency procedure cards that show a 727 painted in the company colors , and even airsickness bags in the seat - back pockets .
with ups express service , you get fast , time - definite delivery of urgent shipments worldwide .
thank you for subscribing to receive email updates from ups . unfortunately due to technical difficulty we have not been added to the ups press release email distribution list . please contact us at + 14048287123
ups has changed its advertising slogan , replacing the “we love logistics” tagline in place since 2010 .
currently , ups runs an international package and document network in more than 220 countries and territories . with its worldwide services , ups moves over 15 million packages through its network each business day .
in 2013 ups advanced worldwide service through becoming the first global express delivery company to be wholly - owned in vietnam . the change allows ups to better connect vietnam ' s rapidly expanding economy to world markets through the ups network . ups expanded into the healthcare market to better reach customers on a global scale with facility openings in china , hungary , australia , italy and north america .
with shipping locations around the globe , ups helps connect your business to the services you need .
ups enters the european market through the start - up of a delivery service in west germany .
ups continued to grow rapidly , aided by trucking deregulation in 1980 . by 1980 ups earned $ 189 million on revenues of $ 4 billion , shipping 1 . 5 billion packages . federal express corporation , however , which began operations in 1973 , was siphoning off a growing amount of ups
ups believes there are promising potential uses for drones to create operational efficiencies within the logistics industry .
the only modern one i really like : vietnam airlines . classy , nice color choices , nice logo , not overdone . their 787 is especially sexy in that motif .
“top - line growth in our business was strong across all business segments , reflecting the power of ups’s global solutions and continued favorable economic conditions , ” said ups chairman and ceo david abney . “when combined with our transformation initiatives , these favorable trends position ups for strong returns going forward . ”
. the company also bought nine small european courier companies to expand air service . its overseas acquisitions cost ups less than $ 100 million . ups and rival federal express both were losing money on overseas operations , but ups had an advantage : federal could not match its $ 6 . 5 billion in assets and $ 480 million in cash with minimal debt . ups hoped this would give it greater staying power as the two companies struggled to build global delivery networks . meanwhile ups slowly won some federal customers by giving volume discounts , which it previously had refused to do . kent c . nelson became ups chairman in 1989 . in 1990 ups bought 17 % of the shipping - related retail outlet
in 1976 ups launched service in germany with 120 delivery vans . it quickly ran into trouble because of cultural and language differences . ups eventually adapted by hiring some german managers and accepting the german dislike of working overtime . george c . lamb jr . succeeded harold oberkotter as ups chairman in 1980 .
ups is making several strategic capital investments for increased global operating capacity ,
ups ceo david abney said in a statement .
these investments will help enable customers to expand their presence in new and existing markets while fueling our profitable growth and attainment of ups ' s long term business objectives .
a large sum for ups , which had rarely advertised . in 1982 ups ran its first - ever television ads , trying to convince executives that two - day service was fast enough for most packages .
total revenue increased 10 % to $ 17 . 1 billion , on strong demand for ups solutions .
since we fly more than 265 heavy jet aircraft , environmental concerns have always been factored into the operation of ups airlines ,
said capt . tom olson , ups flight operations fuel manager .
but in today ' s world of rising prices , it ' s more critical than ever to operate efficiently . our fuel conservation initiatives are innovative as well as environmentally friendly .
with u . s . airlines at various stages of equipping their aircraft with jan . 1 , 2020 mandate - compliant ads - b out solutions , jetblue , ups and acss provide industry perspectives on some of the earliest adoptions of acquiring , installing and operating with the mandated equipment .
the northwest airlines ticket counter received its new brand name at the minneapolis airport in march 2009 . the merger of delta air lines with northwest created the nation ' s biggest carrier .
dhl ( tasman cargo airlines ) boeing 757 - 236 ( f ) vh - tca ( msn 25620 ) ( jeremy clarkson ) syd ( john adlard ) . image : 940837 .
ups ( nyse : ups ) is a global leader in logistics , offering a broad range of solutions including transporting packages and freight ; facilitating international trade , and deploying advanced technology to more efficiently manage the world of business . headquartered in atlanta , ups serves more than 220 countries and territories worldwide . the company can be found on the web at urltoken or pressroom . urltoken and its corporate blog can be found at longitudes . urltoken . to get ups news direct , follow @ ups _ news on twitter .
in coordination with the faa , ups is testing automatic dependent surveillance - broadcast ( ads - b ) technology on 104 of ups ' s 757 and 767 aircraft . among other things , this technology allows ups to proactively manage aircraft departure queues instead of relying solely on air traffic controllers , which in turn reduces fuel use and emissions . ups has the world ' s only fleet equipped with this advanced technology .
in 1976 ups launched service in germany with 120 delivery vans . it quickly ran into trouble because of cultural and language differences . ups eventually adapted by hiring some german managers and accepting the german dislike of working overtime . george c . lamb jr . succeeded harold oberkot - ter as ups chairman in 1980 .
nevertheless , airline executives have started thinking again about consolidation , particularly in the wake of the success of the merger of delta air lines with northwest airlines , which created the nation’s biggest carrier . with travel starting to pick up and credit more widely available than it was one or two years ago , airlines may also be trying to position themselves for the expected rebound .
ups ( nyse : ups ) is a global leader in logistics , offering a broad range of solutions including transporting packages and freight ; facilitating international trade , and deploying advanced technology to more efficiently manage the world of business . headquartered in atlanta , ups serves more than 220 countries and territories worldwide . the company can be found on the web at urltoken ® and its corporate blog can be found at longitudes . urltoken . to get ups news direct , visit pressroom . urltoken / rss or follow @ ups _ news .
i would have given malaysia airlines a ” c “ . it ` s not great but it ` s ok . to be honest , the three most horrible new liveries out there are american airlines , etihad and alitalia . am i seeing things or what , but it looks like alitalia ` s new livery includes painting the wings a pearl white ( weird ! ! ! ) . i was catching an iberia flight out of madrid to o ` hare and i was literally embarrassed when an american airlines 767 with the new livery taxied past the gate i was sitting at ( i ` m american ) . i would like to know who the airlines are hiring to do these new liveries . i could do better on scrap of paper .
in 1982 ups decided to offer overnight air service ( ups next day air ) , charging about half of fedex ' s rate . by 1983 its second - day and next - day services were shipping a combined 140 , 000 packages a day . in 1982 ups earned $ 332 million on $ 5 . 2 billion in sales . it had a fleet of more than 62 , 000 trucks . mail - order firms and catalog houses were the fastest growing part of ups ' s business . jack rogers became ups chairman in 1984 . in 1985 ups began offering international air service between the united states and six european countries .
- - in coordination with the faa , ups is testing automatic dependent surveillance - broadcast ( ads - b ) technology on 104 of ups ' s 757 and 767 aircraft . among other things , this technology allows ups to proactively manage aircraft departure queues instead of relying solely on air traffic controllers , which in turn reduces fuel use and emissions . ups has the world ' s only fleet equipped with this advanced technology .
ups airlines is launching a daily nonstop flight from its worldport® global air hub in louisville , ky . , to dubai , uae , improving time - in - transit from north and south america to key destinations in the middle east by a full business day . the flight , operated with one of ups’s new boeing 747 - 8f freighters , is part of the build out of ups’s smart global logistics network and takes place as the company plans for its role as official logistics provider for expo 2020 dubai .
the job market has changed greatly and ups has been left behind . payment and benefits are below par .
start in our ups help centre for tips about services , solutions , and faqs or search by topic .
ended plans for an overnight air service , and ups terminated united air express in 1931 ; the company did not resume air service until the 1950s . in the late 1940s the urban department stores that ups serviced began following their clients to the new suburbs . more people owned cars and picked up their own parcels . ups
ended plans for an overnight air service , and ups terminated united air express in 1931 , with resumption of air service not coming until the 1950s . in the late 1940s the urban department stores that ups serviced began following their clients to the new suburbs . more people owned cars and picked up their own parcels . ups
start in our ups help center for tips about services , solutions , and faqs or search by topic .
with shipping locations around the globe and around the corner , ups makes it easier to find reliable shipping .
ups is a primary user of the md 11f . the developers will most definitely add it . : )
as talk of big mergers returns , the question is whether all the old arguments still hold . united airlines and continental airlines have reopened talks that were dropped two years ago , even as united is discussing a tie - up with us airways . if any of these deals are made , another brand name will disappear , joining twa , pan am and northwest , among others .
brendan ' s proven track record in a range of key operational functions makes him ideally suited to lead the ups airlines , which plays a critical role in our operations as well as growth strategy ,
said scott davis , ups chairman and ceo .
his knowledge , strategic insight and experience both globally and in louisville , will be of value in leading one of our most important locations .
ups continued to grow rapidly , aided by trucking deregulation in 1980 . by 1980 ups earned $ 189 million on revenues of $ 4 billion , shipping 1 . 5 billion packages . federal express corporation ( fedex ) , however , which began operations in 1973 , was siphoning off a growing amount of ups ' s business . fedex shipped packages overnight by air , and many businesses began shipping high - priority packages with fedex . ups had the resources to challenge fedex , but it meant taking on signifi - cant debt , something the conservatively run ups was reluctant to do . in 1981 it had only $ 7 million in long - term debt and a net worth of $ 750 million . to compete with fedex , ups bought nine used 727 airplanes in 1981 from braniff airlines for $ 28 million . it opened an air hub in
the agreement was voted on by 98 . 7 % of the association membership , with 91 . 6 % percent voting to ratify . terms of the agreement become effective sept . 1 , 2016 and run through sept . 1 , 2021 . the contract covers 2 , 579 pilots at ups airlines .
operating out of its worldport headquarters at louisville international airport , ups airlines services shipping and logistics functions for just about every country worldwide . the company’s dedicated air freight fleet is rumored to be pursuing orders for the boeing 777 freighter , which would add further capacity and functionality to an already impressive operation .
in the past year there have been 35 requests by passenger airlines to take off or land outside their scheduled time and during the curfew period . of those 19 were refused and 16 approved .
much of china airlines cargo operations are shrouded in mystery , as is much of the country . what is known is that the company is perennially in the top 10 worldwide in terms of volume carried . china airlines cargo’s fleet is made up of 19 boeing 747 - 400f planes , and is expected to expand with the addition of boeing 777s or airbus a330 wide - bodied freighters .
when yan wang flew with united airlines from shanghai to chicago at the end of november , she found the flight attendants’ mandarin very awkward . she also realized her “chinglish” didn’t help the communication .
beyond its new north american routes , hong kong airlines - - founded in 2006 - - flies from its hong kong hub to more than 30 destinations across asia , australia and new zealand .
a worker polishes off a newly - installed sign at terminal 3 at los angeles international airport on may 13 , 2017 during a major relocation effort that saw 15 airlines shifting in five nights .
s business . federal shipped packages overnight by air , and many businesses began shipping high - priority packages with federal . ups had the resources to challenge federal , but it meant taking on significant debt , something the conservatively run ups was reluctant to do . in 1981 it had only $ 7 million in long - term debt and a net worth of $ 750 million . to compete with federal , ups bought nine used 727 airplanes in 1981 from braniff airlines for $ 28 million . it opened an air hub in
aircraft every aircraft in ups ' s fleet meets the strictest noise - reduction standards . ups was the first major airline in north america to reach full fleet compliance with the new noise rules . our fleet currently includes 747 ' s , 757 ' s , 767 ' s , a300 - 600 ' s and md - 11 ' s . ups serves more than 220 countries using a combination of more than 500 ups and chartered aircraft .
captain houston mills , ups airlines’ director of safety , is a member of the faa’s drone advisory committee ( dac ) , allowing him to offer a unique perspective , both representing a company that sees the commercial potential in drones , and as a licensed commercial pilot who understands the imperative for safe operations .
well , to start off , i would disagree with the author’s opinion about the liveries of frontier airlines and aerolinas argentinas - i think they both look classy , except for the tail on the latter of course… others look pretty bad though . especially etihad and spirit liveries . as for southwest airlines livery , the newer livery isn’t that bad - but i agree that the older one looked better . lastly , as an example of airlines that did get it right , i think i should mention air india . they changed theirs in 2007 iirc , but they have done a good job of it…
the anniversary passed quietly on friday , as media attention was fixed on the super bowl . but in louisville , ky , the 20th anniversary of ups airlines is a pretty big deal . starting in 1988 with two dc - 8s - - which remain in service - - ups is now the ninth - largest airline in the world , with 268 aircraft and 3 , 000 pilots . and it ' s still growing .
over time , ups has become a leader in global supply chain management . at ups , global distribution and logistics involves managing not only the movement of goods , but also the information and funds that move with those goods .
bonney , joseph ,
ups bets a billion ,
american shipper , january 1993 , p . 26 .
lukas , paul ,
ups : the whole package ,
fortune small business , april 12 , 2003 .
1992 – the triangle airport noise coalition presented the quiet airline award to ups at the raleigh - durham airport .
ups works hard to educate customers on properly packing and shipping high - energy items like lithium - ion batteries .
months of collective bargaining have culminated in a tentative agreement for ups and the international brotherhood of teamsters . the five - year agreement , which is subject to ratification , covers teamsters - represented ups employees in small package roles .
the move away from the 727s won’t cost any jobs , because ups continues to add pilots , giuffre said .
wow , such spectacular logic . as it stands right now , ups owns three of world ' s aircraft .
so are they the a subsidairy of ups , you could have explained decently instead of acting like a bitch .
1 . deregulation in the trucking industry 2 . global expansion through tie - ups 3 . online shopping and distribution
joe reagan , president of greater louisville inc . , the metro chamber of commerce , tells the louisville courier - journal ,
ups airlines ' headquarters is almost like a hidden jewel .
he adds most people living in the area associate the international air hub so closely with the ups brand , they don ' t know the airline is a separate division of the company , one which didn ' t exist before 1988 .
…support when their strike against united parcel service ( ups ) stopped the delivery of thousands of packages worldwide . the strike centred on the extensive use of part - time employees by ups . in the agreement negotiated with ups , the teamsters won 10 , 000 new full - time jobs over the course of the five - year contract . in…
just curious if anyone has the figures and breakdown of the number of aircraft being operated by these two freight giants . on a sidenote , are these the two biggest fleets in america including commercial airlines ?
in terms of lift , however , the fleets are more comparable than these numbers would suggest . almost 300 of the fedex - owned fleet are props , almost all of which are operated by contractors , if i understand things correctly . ups , on the other hand , doesn ' t own its contractors ' 309 aircraft . fedex ' s jet fleet is still about a third larger in pure aircraft numbers than ups airlines ' fleet .
ups tracking solutions show the progress of your shipment every step of the way , across town or around the world .
it plays on the idea of a different interpretation of the ups acronym , which actually stands for united parcel service .
the company ' s supply - chain management operations are merged to form a new unit , ups supply chain solutions .
guilford , roxanna ,
ups reinvents itself as international company ,
atlanta business chronicle , november 12 , 1999 .
the 747 - 8s are part of a larger strategic plan at ups to invest in capital assets that facilitate growth .
ups shares the faa’s focus on safety and security when it comes to establishing new regulatory environments for commercial drone usage .
quoting sp90 ( reply 7 ) : i mean one has ups on the tail and the other has the globe . the colors are also different since ups is white , yellow and brown and world is white , red and blue .
ups united parcel service swot analysis | usp & competitors | brandguide | mba skool - study . learn . share .
former ups airlines president dick oehme , who retired to vero beach , fl , recalled the seven - year effort to create the new carrier from scratch , starting in 1981 . oehme told the courier - journal he began his career with ups as a package - car washer , and had climbed the ranks to become an assistant region manager when he landed on a committee to investigate adding next - day air service to compete with federal express .
as for hong kong airlines , the a350s it will use for the los angeles route will be brand new to its fleet . the carrier ' s first a350 made its maiden flight at airbus ' assembly line in toulouse , france , just last week . it ' s the first of 15 a350s hong kong airlines has on order and is expected to be delivered to the carrier by the end of the month .
in 1929 ups began air delivery through a new division , united air express , which put packages on to passenger planes . the great depression ended plans for an overnight air service , and ups terminated united air express in 1931 ; the company did not resume air service until 1953 , when ups air was launched as a two - day service connecting major cities on the east and west coasts . in the late 1940s the urban department stores that ups serviced began following their clients to the new suburbs . more people owned cars and picked up their own parcels . ups ' s revenue declined .
this instant passenger cabin was more comfortable and met stricter safety requirements than those on most full - time passenger jets . the rows were 33 inches apart , compared with 29 to 30 inches for coach class on most airlines , and they hold their shape against 16 times the force of gravity , a federal aviation administration requirement for new or refurbished aircraft , compared with 9 for typical seats . and the ups airlines seats , conforming with another new f . a . a . rule , do not give off toxic smoke if they catch fire .