bionovo ( nasdaq : bnvi.ob ) was an american biotechnology company focused on the discovery and development of botanically derived treatments for women 's health and cancer based in emeryville , california .

the company had two drug candidates in u.s. food and drug administration ( fda ) clinical trials - menerba ( formerly known as mf101 ) a selective estrogen receptor beta agonist for hot flashes associated with menopause and bezielle ( formerly bzl101 ) for advanced breast cancer .

the company has ceased activity and its stock , although still listed , not moved from 0,00 usd since the end of 2012 .

no statement has been made by the management , nor any indication has been given that the company is still active .

the last press statement was about the sell of all the technical equipment and lay off of 90 % of the staff .

in short words , the company is as good as bankrupted and shut down , although the management never officially admitted it .

bionovo

, m . d . , bionovo ' s president and chief medical officer .
bionovo announced that the us patent and trademark office has issued a patent covering a method of using bionovo ' s proprietary drug candidate bezielle for the treatment of metastatic breast cancer . the patent issued is bionovo ' s second issued patent , with over 70 other patent applications currently pending . bionovo ' s us patent no . 7 , 700 , 136 covers a method of treating breast cancer using an extract of scutellaria barbata .
contact : company , tom chesterman of bionovo , inc . , + 1 - 510 - 601 - 2000 , investor @ bionovo . com ; or investor , joe diaz , robert blum , or joe dorame , all of lytham partners , llc , + 1 - 602 - 889 - 9700 , bnvi @ lythampartners . com , for bionovo , inc .
a pharmacognosy colleague contacted me on friday morning with word that the botanical drug development company bionovo was closing its chemistry group .
bionovo chairman and ceo isaac cohen added that the results from the trial will be submitted to the food and drug administration for approval .
what is a sad story is all the money used for mary and issac salaries and expenses on the backs granst and bionovo common shareholders .
emeryville , ca - bionovo , inc . recently announced that the fda has reviewed the company ' s manufacturing and control process descriptions ( cmc ) , and has provided guidance on how bionovo can move forward with the development of menerba ( formerly named mf101 ) for menopausal hot flashes .
bionovo entered into a two - year securities purchase agreement for up to $ 5 million with socius cg ii ltd . bionovo inc . ( nasdaq : bnvi ) , emeryville , calif . business : endocrine / metabolic , cancer date announced : 1 / 3 / 12 . . .
and is traded on the nasdaq capital market under the symbol ,
bnvi
. for more information about bionovo and its programs , visit :
bionovo , which has 97 . 7 million shares of common stock outstanding , has lost more than $ 87 million since its inception 10 years ago . the company also said in an sec filing that it could be sued for breach of contract by socius cg ii ltd . , a bermuda unit of socius capital group llc , with which bionovo made a stock deal in january . socius could seek $ 250 , 000 , bionovo said .
bionovo , inc . bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in emeryville , california and is traded on the nasdaq capital market under the symbol ,
bnvi
. for more information about bionovo and its programs , visit urltoken .
bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in emeryville , california and is traded on the nasdaq capital market under the symbol ,
bnvi
. for more information about bionovo and its programs , visit http : / / www . bionovo . com .
bionovo , inc . is a pharmaceutical company focused on the discovery and development of safe and effective treatments for womens health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in emeryville , california and is traded on the nasdaq capital market under the symbol , bnvi . for more information about bionovo and its programs , visit : http : / / www . bionovo . com .
bionovo has been the rare superb example of a company that’s been trying to develop fda - approvable drugs based on chinese traditional medicine . led by isaac cohen , a ucsf guest scientist and doctoral of oriental medicine , and chief medical officer , mary tagliaferri , bionovo took a hard , science - based approach to
but even with the fda’s accelerated botanical drug guidelines , the financial sustainability of bionovo has only allowed it to get one drug as far as phase iii .
bionovo , inc . is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in emeryville , california and is traded on the nasdaq capital market under the symbol ,
bnvi
. for more information about bionovo and its programs , visit : http : / / www . bionovo . com .
with a stock price as high as $ 29 . 50 in april 2007 , bionovo closed at $ 0 . 09 / share on friday before the formal announcement . i hope that an entity with a similar mindset on botanical drugs picks up the intellectual property of bionovo and continues with the work they have pioneered .
natural product chemist salaries at bionovo can range from $ 77 , 299 - $ 85 , 202 . this estimate is based upon 2 bionovo natural product chemist salary report ( s ) provided by employees or estimated based upon statistical methods . see all natural product chemist salaries to learn how this stacks up in the market .
bionovo , a drug discovery and development company , has reported promising data describing predictable estrogen regulatory elements that can be used to identify estrogenic drugs that are safer .
he also said that bionovo is at the forefront of future serm products which are far more specific and safe . it is a breakthrough for all future drugs that regulate the diverse effects of conditions affected by nuclear receptors and bionovo is positioned to explore and exploit these pathways for many serious diseases with its expanded scientific collaborations , he added .
bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in emeryville , california and is traded on the nasdaq capital market under the symbol ,
bnvi
. for more information about bionovo and its programs , visit urltoken .
bionovo , inc . is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , markets with significant unmet needs and billions in potential annual revenue . the company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action . based on the results of early and mid - stage clinical trials , bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets . bionovo is headquartered in
in 2002 , tagliaferri and cohen left buck to establish bionovo , where they began phase ii trials of bzl101 in april 2006 , expanding their studies to 10 hospitals and breast cancer centers , including the university of chicago medical center , duke university medical center and the m . d . anderson cancer center in houston . bionovo expects the second phase of trials to conclude by early 2008 .
the study was conducted by investigators at the center for reproductive sciences in the department of obstetrics , gynecology and reproductive sciences at the university of california , san francisco in collaboration with scientists at bionovo .
mary tagliaferri , bionovo president and chief medical officer , said earlier toxicology data and the mechanism of action , showed that higher doses of menerba were safe and demonstrated a level of efficacy similar to hormone therapy .
bionovo retained cowen and co . to explore strategic options due to a lack of cash needed to meet its near term needs , including the completion of a phase iii trial with menerba to treat . . .
bionovo has made a significant commitment to the field of pharmacognosy and ethnomedicine in trying to bring forward traditional remedies to approved botanical drugs . they invested in the hires of several excellent natural products chemists , including some of our own colleagues . and those folks that i’ve met from bionovo , especially isaac cohen , are delightful people dedicated to using crosscultural knowledge to improve human health . you couldn’t help but pull for them to be successful .
bionovo inc . , which last week laid off more than 90 percent of its workforce , said monday that it will net $ 740 , 000 by selling 14 . 2 million shares of its common stock and warrants .
bionovo inc . ( nasdaq : bnvi ) , emeryville , calif . business : endocrine / metabolic , cancer hired : david boyle as svp and cfo , formerly svp and cfo of avi biopharma inc . . . .
bionovo said it will voluntarily delist its shares from nasdaq , effective feb . 17 . the company said it would be unable to regain compliance with the $ 1 minimum bid price requirement for continued listing and plans . . .
, o . m . d . , chairman and ceo of bionovo .
the discussion with the fda was also fruitful concerning future potential labeling of menerba . bionovo provided additional data to support our claim that menerba is not an estrogen and not a serm . the fda acknowledged that menerba is a selective estrogen receptor beta agonist . granted we continue to show no safety concerns after the phase 3 trials , menerba will provide a safer alternative to current hormone therapy .
tripathy also says that companies like bionovo have a tough time getting funding either from the private sector or from pharmaceutical companies :
in the absence of controlled clinical trials , people are skeptical and say ' there ' s no evidence this works , '
he says . bionovo , which expects to begin phase iii trials in 2009 , hopes to upset this way of thinking . and , says tagliaferri , the company is studying about two dozen other chinese herbs with anticancer potential .
while announcing the layoff of some 45 employees friday — based on the size of its workforce that it disclosed in february — bionovo said cash compensation for management also will decrease until adequate financing can be lined up or the company is sold .
biotech company bionovo has begun a phase 3 clinical trial designed to assess the safety and efficacy of two doses of oral estrogen receptor beta ( er - b ) selective drug , menerba ( mf101 ) , used to treat menopausal hot flashes .
bionovo reduced headcount by over 90 % to save cash . at feb . 27 , the company had 52 full - time employees . the remaining management said it will cease operations if sufficient funds are not received or if the . . .
bionovo has reported that the first patient has now been randomized and will begin dosing in the phase iii pivotal clinical trial evaluating the safety and efficacy of two doses of menerba ( mf101 ) among a cohort of postmenopausal women for the treatment of menopausal hot flashes .
isaac cohen , chairman and ceo of bionovo , said : the discovery of these selective estrogen regulatory elements strengthens our selective estrogen receptor modulator discovery engine . the advantage of the new array , of specific regulatory elements , is manifest in the pharmacological and toxicological insights gained .
an independent dsmb recommended continuation of the double - blind , placebo - controlled u . s . phase iii mf101 - 004 trial based on safety data from 66 patients who received menerba for > = 30 days . last month , bionovo halted enrollment in the trial . . .
bionovo , which purports to use traditional chinese medicine in its drug development process , took its “hot flashes” drug menerba into phase iii . an advanced breast cancer drug has completed two phase i studies , and the company was hoping to take a topical treatment for vaginal atrophy into the clinic .
even more interesting to me was bionovo’s extract of scutellaria barbata ( bzl101 , bezielle ) . given the recent enthusiasm in searching for drugs that targeted the aerobic glycolysis phenotype of many cancers , bzl101 was exciting because it had these effects in cell culture and was formulated into an oral preparation with good bioavailability .
bionovo had $ 2 . 5 million in cash and equivalents and another $ 500 , 000 in short - term securities as of dec . 31 , the company said in a securities and exchange commission filing . that figure had fallen to $ 311 , 000 as of monday , it said in the filing .
the company in november moved production employees from aurora , colo . , to hayward , where last year it signed a 10 - year , non - cancelable operating lease with biomed realty trust . the lease calls for payments starting at $ 18 , 750 and for bionovo to grow to 51 , 472 square feet beginning in 2015 .
, o . m . d . , chairman and chief executive officer of bionovo .
menerba ( mf101 ) has an enormous proven market and extraordinary market appeal due to its botanical origins and the safety and efficacy it demonstrated to date . we expect to have top - line data from this study in approximately 18 months .
bionovo inc . ( pink : bnvi ) , emeryville , calif . business : endocrine / metabolic , cancer date announced : 2 / 8 / 12 type : private placement of convertible preferred stock and warrants to be raised : up to $ 25 million price prior : $ 0 . 13 placement agent : cowen shares outstanding . . .
we are pleased to announce that we are initiating the phase 1 tolerability clinical trial . we are confident that the trial will proceed quickly and successfully . we are diligently executing on all our milestones , clinical and non - clinical activities , in 2011 ,
commented dr . isaac cohen , chairman and chief executive officer of bionovo , inc .
/ prnewswire - firstcall / - - bionovo , inc . ( nasdaq : bnvi ) , a pharmaceutical company focused on the discovery and development of innovative treatments for women ' s health and cancer , today announced that it had received the minutes from the u . s . food and drug administration ' s ( fda ) clinical guidance meeting that took place on
bionovo inc . ( pink : bnvi ) , emeryville , calif . business : endocrine / metabolic , cancer date announced : 3 / 12 / 12 type : private placement of common stock and warrants to be raised : about $ 426 , 951 shares : 14 . 2 million price prior : $ 0 . 09 shares outstanding prior : 60 . 6 million . . .
we have concluded three cmc discussions with the fda , and are moving to address the agency ' s recommendations for further development of menerba . the recommendations with respect to the analytical characterization were made by the pre - marketing division of the agency , in order to ensure continuous drug consistency . there are some areas of the drug development process requiring further discussion on how to best implement the agency ' s guidance for industry for botanical drug products . bionovo will be moving with all possible diligence to reach agreement on these areas with the fda . we will start manufacturing the clinical material using the commercial process immediately . during these discussions no concerns were expressed about either the safety nor the efficacy of menerba ,
said dr . isaac cohen , bionovo ' s chairman and ceo .
emeryville , calif . , march 2 / prnewswire - firstcall / - - bionovo , inc . ( nasdaq : bnvi ) today announced the online publication of a peer - reviewed article in the journal , menopause , reporting menerba ( tm ) ( formerly mf101 ) is well tolerated , safe and effective for the treatment of vasomotor symptoms ( hot flashes and night sweats ) associated with menopause .
( i should make the disclaimer here that my wife , a former duke university breast oncologist , enrolled patients in a phase i trial of bzl101 and was co - author of a 2008 asco abstract on the results . however , she received no personal compensation for this work and we have never owned stock in bionovo . we just admire what they are trying to do in women’s health . )
emeryville , calif .  november 10 , 2010  bionovo , inc . ( nasdaq : bnvi ) , a pharmaceutical company focused on the discovery and development of safe and effective treatments for womens health and cancer , today announced that the u . s . food and drug administration ( fda ) has approved the companys total clinical development plan for menerba , the companys drug candidate for menopausal hot flashes .
the positive results of menerba to date are very encouraging . our discussions with the fda clinical staff , our scientific advisory board , our clinical investigators , and our reception at the many scientific conferences at which we have presented - - all have served to strengthen our confidence that bionovo ' s menerba will be able to provide menopausal women with a safe and efficacious alternative to the existing drugs on the market . this is particularly important because all current drugs for hot flashes carry six black box warnings by the fda for potentially serious adverse events . as a next step , we have plans to meet with the clinical review team at the fda to reach an agreement on the clinical path forward ,
said dr . mary tagliaferri , m . d . , bionovo ' s president and chief medical officer .
bionovo , inc . ( nasdaq : bnvi ) , a pharmaceutical company focused on the discovery and development of safe and effective treatments for women ' s health and cancer , today announced that enrollment has started for the phase 1 clinical trial testing the safety of two doses of menerba in postmenopausal women for the treatment of menopausal hot flushes ( study # mf101 - 008 ) , also known as
menopausal hot flashes .
jim stapleton , mba , joined the company on may 2 , 2016 as the cfo , and brings over 25 years of public company cfo experience across a wide range of industries . specific to mt . tam , mr . stapleton was the cfo of bionovo , a clinical state drug discovery and development company from 2005 through 2007 , and was the cfo of a biotech device company , biotech solutions and is responsible for raising more than $ 100m from institutional investors while serving as cfo for both companies .
some of their early work was with a molecular endocrinology physician - scientist dale leitman , then at ucsf . leitman has a solid track record in the transcriptional regulation of estrogen receptor - beta ( erβ ) , particularly by natural products such as soy isoflavones . leitman led the group that reported in 2007 that a 22 - herb extract , bionovo’s mf101 ( menerba ) , had selective erβ agonist activity with the potential for treating menopausal symptoms without increased risk of breast cancer . this extract advanced to phase iii trials last october .
this release contains certain forward - looking statements relating to the business of bionovo , inc . that can be identified by the use of forward - looking terminology such as
believes ,
expects ,
or similar expressions . such forward - looking statements involve known and unknown risks and uncertainties , including uncertainties relating to product development , efficacy and safety , regulatory actions or delays , the ability to obtain or maintain patent or other proprietary intellectual property protection , market acceptance , physician acceptance , third party reimbursement , future capital requirements , competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated , believed , estimated or expected . certain of these risks and uncertainties are or will be described in greater detail in our filings with the securities and exchange commission , which are available at urltoken . bionovo , inc . is under no obligation ( and expressly disclaims any such obligation ) to update or alter its forward - looking statements whether as a result of new information , future events or otherwise .
emeryville , calif . , jan . 14 / prnewswire - firstcall / - - bionovo , inc . announced today the publication of their results from its phase 1b clinical trial of bezielle ( bzl101 ) for metastatic breast cancer . the results of the study are available online in breast cancer research and treatment and demonstrate that bezielle continues to be safe and well tolerated with clinical evidence of anticancer activity in a heavily pretreated population of women diagnosed with metastatic breast cancer . preliminary results from this study were released previously by the company .
emeryville , ca / prnewswire - firstcall / - - bionovo , inc . ( nasdaq : bnvi ) announced today the publication of their results from its phase 1b clinical trial of bezielle ( bzl101 ) for metastatic breast cancer . the results of the study are available online in breast cancer research and treatment and demonstrate that bezielle continues to be safe and well tolerated with clinical evidence of anticancer activity in a heavily pretreated population of women diagnosed with metastatic breast cancer . preliminary results from this study were released previously by the company .
forward looking statements this release contains certain forward - looking statements relating to the business of bionovo , inc . that can be identified by the use of forward - looking terminology such as
believes ,
expects ,
or similar expressions . such forward - looking statements involve known and unknown risks and uncertainties , including uncertainties relating to product development , efficacy and safety , regulatory actions or delays , the ability to obtain or maintain patent or other proprietary intellectual property protection , market acceptance , physician acceptance , third party reimbursement , future capital requirements , competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated , believed , estimated or expected . certain of these risks and uncertainties are or will be described in greater detail in our filings with the securities and exchange commission , which are available at urltoken . bionovo , inc . is under no obligation ( and expressly disclaims any such obligation ) to update or alter its forward - looking statements whether as a result of new information , future events or otherwise .
this phase 1 clinical trial is testing two doses of menerba that are higher than the already proven efficacious dose evaluated in our phase 2 trial , which showed efficacy equivalent to recently approved low dose menopausal hormone therapy ( mht ) . we are escalating the dose of menerba to reach similar efficacy as the high doses of mht . our goal is to define a full therapeutic window that matches or improves on currently approved mht drugs ,
said mary tagliaferri , m . d . , bionovo ' s president and chief medical officer .
this release contains certain forward - looking statements relating to the business of bionovo , inc . that can be identified by the use of forward - looking terminology such as believes ,  expects ,  or similar expressions . such forward - looking statements involve known and unknown risks and uncertainties , including uncertainties relating to product development , efficacy and safety , regulatory actions or delays , the ability to obtain or maintain patent or other proprietary intellectual property protection , market acceptance , physician acceptance , third party reimbursement , future capital requirements , competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated , believed , estimated or expected . certain of these risks and uncertainties are or will be described in greater detail in our filings with the securities and exchange commission , which are available at http : / / www . sec . gov . bionovo , inc . is under no obligation ( and expressly disclaims any such obligation ) to update or alter its forward - looking statements whether as a result of new information , future events or otherwise .
this release contains certain forward - looking statements relating to the business of bionovo , inc . that can be identified by the use of forward - looking terminology such as
believes ,
expects ,
or similar expressions . such forward - looking statements involve known and unknown risks and uncertainties , including uncertainties relating to product development , efficacy and safety , regulatory actions or delays , the ability to obtain or maintain patent or other proprietary intellectual property protection , market acceptance , physician acceptance , third party reimbursement , future capital requirements , competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated , believed , estimated or expected . certain of these risks and uncertainties are or will be described in greater detail in our filings with the securities and exchange commission , which are available at http : / / www . sec . gov . bionovo , inc . is under no obligation ( and expressly disclaims any such obligation ) to update or alter its forward - looking statements whether as a result of new information , future events or otherwise .
emeryville , calif . , jan . 14 / prnewswire - firstcall / - - bionovo , inc . ( nasdaq : bnvi ) announced today the publication of their results from its phase 1b clinical trial of bezielle ( bzl101 ) for metastatic breast cancer . the results of the study are available online in breast cancer research and treatment and demonstrate that bezielle continues to be safe and well tolerated with clinical evidence of anticancer activity in a heavily pretreated population of women diagnosed with metastatic breast cancer . preliminary results from this study were released previously by the company .
bionovo , inc . ( otc link platform : bnvi . pk ) today announced that it will need to obtain substantial additional funding to achieve its objectives of internally developing drugs . the company reduced its workforce by over 90 % . the remaining management of the company will receive reduced cash compensation until either adequate financing can be obtained or the company is sold . the company can not make any assurances about either of these events . as previously announced , management and the board of directors are continuing to explore strategic options for the company . management is currently reviewing the status of the ongoing clinical trial for menerba .
menerba is a first - in - class , unique drug candidate that is intended for a large medical need , for the safe and effective treatment of menopausal symptoms ,  said isaac cohen , bionovos chairman and chief executive officer . we want to do everything necessary to bring menerba to market for the treatment of hot flashes , while we also investigate its potential use in the treatment of breast cancer prevention . now that we have agreements with the fda and the ema ( the european medicines agency ) on the overall development of menerba , we have accelerated discussions with potential partners to successfully bringing menerba to market .
for bionovo , the drug discovery and development company in emeryville , calif . , that ' s behind bzl101 , there ' s hope too . the trial is the first fda - validated clinical study of a potential cancer drug derived from a chinese medicinal herb , says dr . mary tagliaferri , a co - founder of the company , former practicing acupuncturist and a breast - cancer survivor .
sixty - two percent of chemotherapy drugs come from natural products , and plants have been the basis of almost every new class of medication ,
she says .
it makes sense that these plants can act as anticancer agents .
large clinical trials , such as the hers and the whi , elucidated serious safety concerns associated with hormone therapy . these results have led to a dramatic drop in the use of estrogens ,
said isaac cohen , chairman and ceo of bionovo , inc .
for this reason , it is important to develop safer alternatives for treating menopausal symptoms currently affecting 30 million women in the us . our results indicate menerba is effective and safe for the treatment of hot flashes and we are eager to move forward with the development of this drug . clearly , menerba has the potential to help millions and reach blockbuster sales soon after market launch .
bionovo , inc . , a development stage company , engages in the discovery and development of drugs in the areas of cancer and women ? s health primarily in the united states . it develops drugs to treat breast and ovarian cancers , and for menopause . the company ? s product and drug pipeline includes mf101 , a selective estrogen receptor beta agonist , which is designed to alleviate the symptoms of menopause , including hot flashes , night sweats , and bone mineral loss ; and bzl101 , an apoptosis inducing factor translocator / activator , which is used as an anticancer agent for breast and ovarian cancers , as well as used for the treatment of other solid tumors . in addition , its drug pipeline , which is not entered human clinical trials includes aa102 , an apoptosis inducer , which is used as an anticancer agent that attenuates mitochodrial membrane potential to cause a cytochrome c release and caspase activation to induce apoptosis ; and vg101 , vasodilator and an antimicrobial agent , which is an intra - vaginal gel for the treatment of postmenopausal vaginal dryness . the company has collaboration with the university of california at san francisco ; university of california at berkeley ; university of california at davis ; university of texas , southwestern ; and university of colorado health sciences college . bionovo was founded in 2002 and is headquartered in emeryville , california .
prior to joining nektar , she was a clinical and regulatory consultant to intermune before its acquisition by roche . she also served as chief medical officer at kanglaite usa , a privately - held biotechnology company which develops oncology drug candidates in multiple solid tumor settings . dr . tagliaferri was also co - founder and president and chief medical officer of bionovo where she led the company ' s clinical drug development strategy and global regulatory affairs , led data management and biostatistics , and oversaw clinical operations and compliance . dr . tagliaferri received the 2012 state of california woman of the year award for her advancements of clinical research in women ' s health and her mentorship of women in the biotechnology field .
the fda at least is eager to see more studies of botanical treatments of cancer .
we ' re not opposed to chinese medicine ,
says dr . shaw chen , botanical review team leader at the fda .
we just like to see clinical studies that meet our standards .
chen agrees it can be tough to study the pharmacological activity of botanical compounds or to ensure consistency in quality , but bionovo ' s efforts , if fruitful , may help pave the way for other research .
a successful application to market for a cancer drug based on chinese medicine will be encouragement to the industry ,
he says .
i think the industry is watching for the first success story .
we are encouraged by the results of the company ' s second phase 1 trial in women with advanced breast cancer and feel the oncology community is equally enthusiastic about bezielle as our manuscript was accepted by the most widely read breast cancer specific peer reviewed journal in two days ,
said mary tagliaferri , president and chief medical officer of bionovo .
there are currently over 160 , 000 women in the united states living with advanced breast cancer who are eagerly awaiting an oral anticancer drug that can extend life without profoundly diminishing quality of life . we believe bezielle will be an important new anticancer agent because its biological selectivity allows the drug to kill cancer cells without affecting normal cells resulting in dramatically fewer side effects .
we had a very positive meeting with the fda on our clinical program for menerba . as anticipated , they agreed with our overall clinical development plan which included the number of clinical trials , number of subjects and length of exposure as well as non - clinical studies necessary for new drug application ( nda ) submission for a non - estrogen drug such as menerba . they also provided useful suggestions for improving the clinical trial protocols ,  said mary tagliaferri , m . d . , bionovos president and chief medical officer . while we are awaiting the formal minutes from the fda meeting , we are moving forward to implement the agencys suggestions and have forwarded the approved clinical trial design to our investigators and their investigational review boards , or irbs .
in the age of sequential monotherapy as the treatment approach for women with metastatic breast cancer , bezielle is one of the most exciting new therapies under investigation today ,
said banu arun , m . d . , department of breast medical oncology , division of cancer medicine , university of texas , m . d . anderson cancer center , houston , texas .
at our center , where over 3 , 000 women are newly diagnosed with breast cancer each year , there is great patient demand for oral drugs with minimal toxicities for the treatment of any stage breast cancer . bezielle is the exact type of drug our patients are seeking and the favorable clinical results in bionovo ' s two early stage clinical trials among a heavily pretreated patient population are extremely encouraging .
bionovo completed a multicenter phase 2 , double - blind , placebo - controlled randomized clinical trial evaluating menerba for the treatment of hot flashes in 217 healthy post - menopausal women enrolled at 6 clinical sites in the u . s . the principal investigator of the trial was dr . deborah grady from the university of california , san francisco . menerba showed a statistically significant reduction in the number of hot flashes after 12 weeks of treatment ( - 62 % , p = 0 . 05 ) and had a statistically significant reduction in nighttime awakenings from hot flashes ( - 67 % , p = 0 . 05 ) . there was no difference in uterine bleeding between treatment groups and placebo , and no uterine abnormalities were observed during the study . the only side effect observed was mild loose stools ( 12 % in treatment group vs . 3 % in the placebo group ) . to date , no significant toxicities have been observed in any of the animal studies with doses ranging from 2000 mg / kg / day in dogs to 16 , 000 mg / kg / day in rodents .
tagliaferri ' s interest in ban zhi lian , which has traditionally been used to treat swellings , sores and fever , was sparked in 1996 by a fellow acupuncturist , isaac cohen , who would later become a co - founder of bionovo . at that time , cohen had been treating , for a decade , women who were battling breast cancer with conventional medicines and had run out of treatment options .
in their exhaustion and desperation , they were trying to find an alternative treatment that was not so harsh ,
says cohen , who often prescribed herbs to be prepared as teas to ease the side effects of chemo and hormone therapy . but the patients ' oncologists , says cohen , discouraged them from trying anything new .
they ' d say chinese medicine was quackery and that there was no evidence it worked ,
he says . still , cohen observed that many of the women to whom he gave chinese herbs , including ban zhi lian , responded well to the herbs and even experienced a relatively good quality of life .
at first i chucked it to luck ,
he says .
but then you see it ' s not just luck . and then you ponder why .
menerba is an oral botanical drug candidate designed for the safe , effective treatment of vasomotor symptoms ( hot flashes ) associated with menopause . menerba is an estrogen receptor beta ( er - b ) selective drug , developed as an alternative to the products currently on the market which have been shown to increase the risk for breast and uterine cancers . it has been shown that the increased risk of breast and uterine cancers is associated with activation of estrogen receptor alpha ( er - a ) and that activation of estrogen receptor beta ( er - b ) blocks the growth promoting effects on breast cancer cells . the active ingredients in menerba are derived from botanicals with centuries of recorded safe , effective use in traditional chinese medicine ( tcm ) . bionovo recognizes the opportunity to commercialize a product that would be as effective as hormone therapy , without the health risks . menerba has completed a phase 2 trial with positive results for efficacy and has been evaluated by an independent data and safety monitoring board and passed through a standard two - round examination for safety . menerba also has been shown in animal studies to prevent the proliferation of breast cancer and to have a beneficial effect on osteoporosis , though this has not yet been studied in humans .
menerba is an oral drug candidate designed for the safe , effective treatment of vasomotor symptoms ( hot flashes ) associated with menopause , which is manufactured from botanical sources . menerba is an estrogen receptor beta ( er - b ) selective drug , developed as an alternative to the products currently on the market which have been shown to increase the risk for breast and uterine cancers . it has been shown that the increased risk of breast and uterine cancers is associated with activation of estrogen receptor alpha ( er - a ) and that activation of estrogen receptor beta ( er - b ) blocks the growth promoting effects on breast cancer cells . the active ingredients in menerba are derived from botanicals with centuries of recorded safe , effective use in traditional chinese medicine ( tcm ) . bionovo recognizes the opportunity to commercialize a product that would be as effective as hormone therapy , without the health risks . menerba has completed a phase 2 trial with positive results for efficacy and has been evaluated by an independent data and safety monitoring board and passed through a standard two - round examination for safety . menerba also has been shown in animal studies to prevent the proliferation of breast cancer and to have a beneficial effect on osteoporosis , though this has not yet been studied in humans .
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study record managers : refer to the data element definitions if submitting registration or results information .
the safety and scientific validity of this study is the responsibility of the study sponsor and investigators . listing a study does not mean it has been evaluated by the u . s . federal government . read our disclaimer for details .
to conduct a prospective , randomized , blinded , placebo controlled , dose escalation clinical trial in 4 cohorts of 10 postmenopausal women ( total n = 40 ) aged 45 to 65 years with at least one menopausal vaginal symptom , vaginal ph > 5 . 0 and > 20 % parabasal vaginal epithelial cells .
the optimal dose of vg101 based on the highest of 4 proposed dose levels that is not associated with unacceptable toxicity during 12 weeks of treatment . toxicity will be based on national cancer institute ( nci ) common toxicity criteria for adverse events ( ctcae ) , version 3 . unacceptable toxicity will be defined as the occurrence of any grade 3 , 4 , of 5 toxicity that is possibly or probably associated with study drug or any other unacceptable toxicity as determined by the data and safety monitoring board .
choosing to participate in a study is an important personal decision . talk with your doctor and family members or friends about deciding to join a study . to learn more about this study , you or your doctor may contact the study research staff using the contacts provided below . for general information , learn about clinical studies .
postmenopausal documented by : ( a ) at least one year of amenorrhea ; ( b ) 6 - 12 months of amenorrhea with serum fsh > 40 iu / ml ; ( c ) 6 weeks post - surgical bilateral oophorectomy with or without hysterectomy , or ( d ) hysterectomy with serum fsh levels > 40 iu / ml .
willing to use an intravaginal cream containing chinese herbs for the treatment of vaginal symptoms .
abnormal pap smear or pelvic examination within the last 9 months suggestive of cancer .
any uterine or vaginal bleeding within the six months prior to enrollment ( except following the screening pap smear ) .
use of any vaginal moisturizer ( replens , ky silk - e , astroglide silken secret , senselle ) within 30 days of screening .
use of any oral , transdermal , vaginal , or systemic estrogen or estrogen / progestin product within 30 days of screening .
any medical or psychiatric condition that , in the investigator ' s opinion , would preclude the participant from completing questionnaires or measures , adhering to the protocol or completing the trial , including limited english literacy , severe illness , plans to move , substance abuse , significant psychiatric problems , or dementia .
to learn more about this study , you or your doctor may contact the study research staff using the contact information provided by the sponsor .
contact : holly richter , m . d . , phd 205 - 934 - 3180 hrichter @ urltoken
contact : deborah grady , m . d . , mph 415 - 353 - 9748 deborah . grady @ urltoken
the chinese herb ban zhi lian may not be in everyone ' s lexicon , but to the 80 women with stage iv metastatic breast cancer , who are participating in the second phase of the bzl101 clinical trials , it represents hope and life .
cohen ' s early observations about ban zhi lian may have started out as a hunch , but they may hold up . in 1996 , cohen and tagliaferri , along with dr . debu tripathy , then a breast cancer specialist at the university of california , san francisco , co - founded the complementary and alternative medicine program at the university ' s carol franc buck breast care center . over the next several years , the trio amassed enough evidence about the herb ' s anticancer properties  in lab tests of animals and breast - cancer cells , bzl101 caused apoptosis or cell death , according to tagliaferri  to get a green light from the fda to begin clinical trials .
the researchers conducted phase i trials at buck and at the cancer research network in plantation , fla . their 21 participants had stage iv metastatic breast cancer , which had continued to progress despite an average of four rounds of standard treatment , including chemo and hormone therapy . the patients took 12 g a day of ban zhi lian , a dose that ' s three times more concentrated than the amount found in a cup of brewed tea . after about a year , 25 % of the patients saw stabilization in their disease for 90 days , and 19 % for 180 days . the experimenters say bzl101 works by preventing cancer cells from undergoing glycolysis , a process of glycogen breakdown that accounts for as much as 85 % of cancer cells ' energy supply .
women with breast cancer have typically sought chinese medical herbalists for relief from the side effects of chemotherapy and radiation or to strengthen and balance their immune systems ; some have even hoped for a cure . some women may have been helped ; others not . but with so many variables  the broad range of patients , quality and potency of the herbs available , types of formulations prescribed and the expertise of the herbalist  outcomes in informal settings were never a sure thing . and it ' s the same kind of variability that has made clinical research so problematic .
even though people are very interested in herbal therapy and a lot of people take herbs , research in herbal therapy is difficult because you ' re dealing with a mixture of compounds ,
says tripathy , who is now a clinical professor of internal medicine at the university of texas southwestern medical center in dallas . during the research phase , tripathy says , scientists often attempt to isolate one particular molecule or compound from the herbal extract  and the anticancer activity is lost .
there are herbal extracts in which the anticancer activity is actually due to the synergy between many of the compounds contained in that extract ,
he says .
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the emeryville - based drug developer ( pink sheets : bnvi ) said the sale of its stock , which closed monday at 6 cents per share , will raise about $ 427 , 000 . it also will receive about $ 344 , 575 if all the warrants are exercised for cash by march 30 into nearly 11 . 5 million shares of stock at 3 cents each .
the company’s largest shareholders as of last month were rothsinvest asset management ag and co - founders isaac cohen and mary tagliaferri .
cohen , who is chairman and ceo , received more than $ 1 . 3 million in compensation last year , including $ 375 , 000 in salary , a $ 9 , 000 - plus car allowance and health care and life insurance premiums . that’s roughly the same compensation as tagliaferri , who serves as president and chief medical officer .
“we will require substantial capital resources in order to conduct our operations and develop our therapeutic products , and do not expect that our current cash and cash equivalents will be sufficient to fund our current and planned operations , ” the company said in the sec filing .
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the company does not currently have adequate internal liquidity to meet its cash needs . if sufficient additional funds are not received in the near term , the company may not be able to execute its business plan and may need to further curtail or cease operations .
for cancer and women’s health issues . cohen and colleagues at ucsf and elsewhere examined chinese herbal medicines for their biochemical and cellular effects based upon their traditional use .
the emeryville , ca , company has been developing traditional chinese medicines as fda - approvable drugs for women ' s health indications .
thanks , lila – i’m just hoping that someone picks up on the work they’ve done thus far . great people and some very interesting science in there .
the safety zone covers chemical safety issues in academic and industrial research labs and in manufacturing . it is intended to be a forum for exchange and discussion of lab and plant safety and accident information without the fanfare of a news article .
i ' m the only one here . i talk to myself . . . haha
for me : yes $ $ $ $ $ $ here . . . . go bnviq
up 290 % over the last month . . . . 39 . 29 % over the
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moneytree , inc. is a check cashing and payday loan provider headquartered in seattle , washington , with branches in washington , california , colorado , idaho , nevada , and british columbia .

moneytree also offers prepaid debit cards , money orders , bill payment , western union transfers , online payday loans , auto equity or title loans .

in 2013 , moneytree won " best place to work in colorado " in the small business category .

moneytree

1 . moneytree when erika herrera went to work for moneytree as a teller , she figured it was just a job that would pay the bills while she finished school .
moneytree works hard to be the best provider of payday loans and other financial services . whether you apply online or in a branch , a moneytree payday loan is fast , simple and secure .
pwc moneytree is the go - to source for venture capital firms and high - growth startups .
moneytree is big on employee recognition ; managers like herrera have budgets and consult with team members to develop their own local recognition programs .
the pwc moneytree website is home to the pwc / cb insights quarterly moneytree report . it contains historical trend data beginning with 1995 , updates on the venture capital and high - growth startups ecosystem , and relevant insights from pwc’s emerging company services and venture capital tax , audit and advisory professionals . the pwc / cb insights moneytree report is the definitive source of information on venture capital investments in emerging companies . this study is a staple of the financial community , entrepreneurs , government policymakers and the business press worldwide .
as a result of that buy - in , amazing things have happened over the years at moneytree . the seattle payday lender has received 27 civic and corporate awards , including repeat turns as a finalist in the best companies to work for competition . this year marks the second in a row moneytree has won the award in the large - company category .
learning the importance of saving account is of the many important money lessons . in moneytree , we emphasize the importance of savings account when it comes to teaching kids about money . …
moneytree works hard to be the best provider of payday loans and other financial services . we are a direct lender and have been exceeding customers ' expectations for over 30 years . a moneytree payday loan is fast , simple and secure . if you have any questions , visit a branch near you or call our customer service team between 6am and 11pm pt , seven days a week !
due to limitations imposed by the military lending act , moneytree does not make loans to
covered borrowers ,
a term which includes active duty members of the military , their spouses and dependents .
the company has 675 employees in washington , and of the hundreds who responded to the best companies survey , most sang moneytree’s praises in such wide - ranging categories as communication , benefits , training and education opportunities , and recognition .
moneytree inc . ’s co - founders , ceo dennis bassford ( left ) , design director sara bassford ( center ) and executive vice president david bassford have a a work environment that follows the company’s core ethos of treating the customer right .
moneytree’s customer service team is open between 6am and 11pm pst , seven days a week 364 days a year ( every day except christmas day ) . if you have any questions , please call 877 . 613 . mony ( 6669 ) .
at moneytree inc . , it’s all about the corporate buy - in : treat people how you want to be treated . that is the mantra , the foundation on which every other corporate decision at the quarter - century - old company is based .
“i tell them if you’re ever thinking about a career change and want to work for a company that treats its employees really well , where you can be part of a bigger picture , that’s a fun place to work with great benefits – think of moneytree , ” herrera says .
as the leading financial literacy education provider in the region , moneytree specialises in providing financial literacy lessons for school going children and youth . we have a comprehensive program that has been developed to educate and engage kids through a fun - filled interactive program that brings the lessons to life .
payday loans are typically repaid on your payday or the following business day . once you ' ve been approved , you will log into your account and choose a date to repay your loan . payday loan payments can be made online , on our make a payment page or at any moneytree branch .
pwc and cb insights ' healthcare moneytree report brings you a quarterly publication based on us venture capital funding for healthcare related industries . each issue is broken out by five key sections : us healthcare trends , us healthcare industries , us healthcare places , us healthcare movers and shakers , and global healthcare trends .
“they gave me a chance when no one else would and i am so grateful to them for that , ” wrote one employee . “i love this job and the company and the people i get to work with every day . moneytree saved my life emotionally and financially and i will never forget that . ”
maybe it was the great benefits , or the employee recognition , or the company’s policy of giving back to the community , or the pleasure of working for a family - owned business that made its employees feel like members . whatever it was , somewhere along the way , herrera stopped thinking of moneytree as a job and began thinking of it as a career .
the rule further extends to the benefit package , which leadership regards as a sacred document . after 90 days , the company fully pays the employee - only health coverage premium , and the insurance plan has an annual deductible of $ 200 . as every business knows , providing coverage gets harder each year , especially in this economy . dozens of moneytree employees surveyed tipped their hat to the available benefits .
and the accolades keep coming , be they customer reviews from yahoo ! and urltoken or the better business bureau , which gave moneytree an a + rating . not bad for a 1983 startup in humble renton headquarters with three owners , david bassford , sara bassford ( david and sara are married ) and ceo dennis bassford , david’s brother . the business has since spread to five states with 1 , 100 total employees .
“i saw myself working for the company long - term , ” says herrera , who is now the seattle - based company’s colorado district manager , overseeing the state’s 10 branches . “i changed my major from criminal justice to business because of moneytree . when i saw the culture they create and how much they give back to their employees and the communities where we live and work – that’s what made me have a passion for this company . ”
thank you for visiting our site ! we’re excited to offer retail financial services in your community . from short - term loans and check cashing to prepaid debit cards and western union wire transfers , we invite you to learn more about our products . make a payment , find a moneytree branch near you or apply online for a loan ! if you have questions , please call our customer service team at 877 . 613 . 6669 or visit our faq page .
we believe that in selecting moneytree , our customers expect that we will take great care to preserve their privacy . as financial services professionals entrusted with sensitive financial information , we respect the privacy of our customers and are committed to treating customer information responsibly . our customer information privacy principles serve as standards for all of our employees in the collection , use , retention and security of individual customer information . we use mcafee and verisign security software and are fully licensed in each state in which we operate .
moneytree , which provides check cashing , payday loans , bill pay services , money orders and wire fund transfers in california , colorado , idaho , nevada , washington and british columbia , has 900 employees in 120 branches . employee satisfaction surveys keep the company on top of what makes its people happy , and senior executives make regular visits to all markets to conduct workshops and give team members a chance to ask questions , share concerns and make suggestions . top - performing employees are invited to ceo circle meetings two to three times a year with the owner and company leadership .
moneytree offers a suite of financial products and services designed to meet our customers’ short and longer - term money management needs . convenient , confidential , and cost - effective , our products and services provide real options to help solve life’s problems . from payday loans , to title loans and installment loans , we have a variety of consumer loans available ( depending on the market ) to meet our customers ' needs . we are a direct lender with branch locations in california , colorado , idaho , nevada and washington . select your state below to find out more about the consumer loans available near you .
convenient , confidential , and cost - effective , from payday loans , to cheque cashing and money orders , we have a variety of services available to meet your short and long term money management needs . cash your paycheque for just 2 . 49 % or take out a moneytree payday loan up to $ 1 , 500 . plus , money orders are free with any cheque cashing or loan transaction . whether you can ' t wait for a check to clear , need cash for an immediate expense , or are looking for fast service , we ' ve got you covered . find a branch in abbotsford , burnaby , surrey or vancouver today !
“i always carry gift cards on me , ” herrera says . “we randomly recognize someone for giving great service , or filling in a shift or doing more than we ask . we also give employees four - day weekends without having to use vacation time . lately , we’ve been giving little getaways . ”
the winner of one recent getaway – a young man in the colorado springs branch – told herrera that the hotel voucher made it possible for him to have a las vegas honeymoon he couldn’t otherwise have afforded .
ten team members who earn perfect scores on monthly customer service assessments performed by “mystery shoppers” are eligible for a $ 200 bonus ; five employees who receive perfect customer service assessment scores for five consecutive months are eligible for a $ 500 monthly bonus .
and a perfect score triggers a company contribution to the district’s community involvement fund , which means more chances to give back . employees decide where the money goes , and the colorado team has supported such charities as the make a wish foundation and food bank of the rockies .
great people make a great company , so when herrera goes shopping and gets terrific customer service , she gives that salesperson her business card and a pitch for her employer .
lisa ryckman is coloradobiz ' s managing editor . contact her at lryckman @ urltoken .
it isn’t a secret – colorado’s economy is vibrant and strong . new developments continue to spring up across the state , many entrepreneurs have started new businesses , and many more companies are growing and need resources to meet their increased demand . what’s the secret to ensure business owners . . .
has the word entrepreneur become too trendy as to have lost its meaning ? i’m hearing it and the word entrepreneurship being used in so many conversations incorrectly . i’m critical of the use of the word
entrepreneur
. . . are you ?
emerging companies comprise a significant portion of colorado businesses . venture capitalists , angel investors and founders make up the shareholders and the boards of directors of many of these companies . i spoke recently to fran wheeler , a partner in the business department of the colorado office . . .
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“it comes from the customer’s standpoint , what makes sense for the customer , ” says david bassford , the company’s executive vice president . “it sounds clichéd but it’s not . ”
such loyalty has been infectious . at a recent companywide branch managers’ meeting facilitated by president aggie clark , the manager with the shortest tenure had been with the company for four years . with such low turnover , the corporate buy - in just solidifies and then becomes self - perpetuating . “they understand the [ golden ] rule as an intuitive thing , ” clark says .
this tendency among employees to think of others has generated ideas such as providing interpreters for non - english - speaking customers and giving a bump in pay to bilingual employees . if a customer speaks swahili , for example , a branch manager can get on the inhouse hotline and locate an employee , regardless of department , who speaks the language and can help that customer .
and co - owner sara bassford , who also serves as the company’s design director , knows the importance of these perks .
“we make a lot of tough decisions , ” she says , “but we’ll get rid of nonessential elements like the plants in the lobby before we give up benefits . ”
columbia bank ceo melanie dressel once received a letter from an employee thanking her and the company itself for providing a work environment she felt good about .
in the letter , the employee explained how her husband had been laid off and that more than one co - worker had come up to her and expressed sympathy and told her to hang in there . that letter , that genuine concern for co - workers , dressel says , embodies what columbia bank is all about .
“we have a real low tolerance for people who are just not nice , ” says dressel . “we always try to hire people who really do care about each other . ” dressel and staff look for people who , during interviews , are very good at conveying what “type of person they are , ” she says . so , if the person is friendly , is someone whom others would like to have around , this candidate would more likely make the short list at columbia .
to further illustrate that ideal , dressel visits each department and branch at least once a year , and there are 50 branches . no computers answer the phone , just employees—sometimes even dressel . she also hosts an event called “breakfast with melanie , ” in which she invites a random group of employees to talk about the industry and what’s happening with the company . culture remains king at columbia .
“in life , ” she says , “you realize it’s really about the relationships that you form and how quality - of - life issues become more important to you . ”
there was a time when it looked as if pathology associates medical laboratories ( paml ) ceo thomas tiffany was taking care of everybody but himself . diagnosed with type 2 diabetes three years ago , he was severely overweight and lacked exercise . not the best role model at a full - service medical reference company that performs just about every kind of health test for physicians , hospitals and employers .
but he changed his ways , and his example has inspired the more than 1 , 000 employees in spokane and helped make paml one of the best places to work in washington .
perhaps the best set example was the “walking with the president” program . tiffany set aside his lunch hour on specific days and walked around the campus with a handful of employees . they had the opportunity to interact with the ceo , and he was able to show them his commitment to change . at first , about 35 people joined him , but soon , there were more than 100 . now the company is also a participant in the city’s popular bloomsday race .
the result ? tiffany has lost 60 pounds , while his employees are fitter and are taking fewer sick days .
the company takes other measures to encourage its employees to stay healthy . employees get a $ 25 gift certificate for taking a mammogram and a $ 50 certificate for completing an online health risk assessment form .
microsoft has a sketchy record when it comes to buying up companies . how will its acquisition of github pan out ?
nationally , the number of deals worth more than $ 1 billion were down 75 percent last year compared to 2016 .
employees at the bank ' s bellevue northup office are thrilled about the culture of their office .
the latest amazon hq2 odds : toronto rises , atlanta falls , d . c . area looks like the front - runner
change makers : gender equity in the workplace is possible . here ' s how .
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it’s our mission to exceed customers’ expectations . if you have questions about our consumer loan products we invite you to visit a branch near you or call our customer service team at 888 . 320 . tree ( 8733 ) . we look forward to exceeding your expectations ! customer notice : payday loans , high - interest loans and title loans should be used for short - term financial needs only and not as a long - term financial solution . customers with credit difficulties should seek credit counseling before entering into any loan transaction . licensed by the department of business oversight pursuant to the ca deferred deposit transaction law to make consumer loans . licensed by the department of business oversight pursuant to the ca finance lenders law to make business loans .
the term of a payday loan is determined by the frequency of your paydays . if your next payday is within 9 days from the date you take out the loan , you can choose to repay your loan on the subsequent payday . in all cases , the minimum loan term is 8 days . the maximum loan term per washington law is 45 days .
washington law also requires that you have not taken out more than eight ( 8 ) payday loans from a washington - licensed payday lender during the prior 12 - month period .
a payday loan costs $ 15 per $ 100 borrowed up to $ 500 , and $ 10 per $ 100 on the amount over $ 500 . for example , the total amount due on a $ 100 loan for 14 days would be $ 115 and has an apr ( annual percentage rate ) of 391 . 07 % . *
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once your application has been approved , you ' ll receive an email with your approved dollar amount . then just log into your account and select how much you ' d like to borrow . if you have any questions about payday loan applications or the approval process , please visit the faq page or call our customer service team at 877 . 613 . 6669 .
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a single payday advance is typically for two to four weeks . however , borrowers often use these loans over a period of months , which can be expensive . payday advances are not recommended as long - term financial solutions .
while funding to vc - backed companies in the united states increased 4 % , reaching $ 21 . 1b invested across 1 , 206 deals , deal activity declined 2 % . a high number of mega - rounds contributed to the funding growth this quarter , which was the second - consecutive quarter with over 30 rounds of $ 100m or more . q1’18 saw 34 mega - rounds to us vc - backed companies , which accounted for 34 % of total funding , but down from 42 % in q4’17 . this marks the first decline since q4’16 .
view current quarter investment data by sector , state , region or stage of development .
for company level information , please contact our provider , cb insights , at info @ urltoken .
view detailed results for the most recent quarter and aggregate trend data , beginning with 2002 .
2018 looks to continue the trend of larger deals as we’ve now seen two consecutive quarters with over 30 rounds of $ 100m or more – only the second time in recent history that this has happened . additionally , the $ 21b we saw invested this quarter is a record high , just the second time we’ve reached this funding level during the last 15 years , and artificial intelligence saw its biggest funding quarter ever ( over $ 1 . 8b ) .
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managing money is a much needed skill that is lacking and not taught in most schools . we teach kids the value of money and progress towards teaching them how to manage and grow the money they have
learning to have a long term perspective on money is important for one to build their financial security . we use activities to help kids understand and develop important money habits like saving , budgeting and investing .
judith rich harris , an american psychologist , said a child’s behaviour is more influenced by the company they keep than by their parents . our lessons focus on helping kids make better money decisions basing on set goals and how to avoid peer influence .
our program has been designed to make it easy to be taught and fun for students . schools can license and deploy our program for their students . schools will be given …
teaching kids about money does not come naturally to many . that’s why we are creating our online learning portal which helps parents coach their kids on money matters .
being protective about your children is natural . but are you protecting them too much ? do you judge parents who encourage their high school children to work ? even if you and …


computer modelling group ltd. , abbreviated as cmg , is a software company that produces reservoir simulation software for the oil and gas industry .

it is based in calgary , alberta , canada with branch offices in houston , dubai , bogota , rio de janeiro , london and kuala lumpur .

the company is traded on the toronto stock exchange under the symbol cmg .

the company offers three reservoir simulation applications .

imex , a conventional black oil simulator used for primary , secondary and enhanced or improved oil recovery processes ; gem , an advanced equation-of-state ( eos ) compositional and unconventional simulator ; and stars a k-value thermal and advanced processes simulator .

in addition , cmg offers cmost , a reservoir engineering tool that conducts automated history matching , sensitivity analysis and optimization of reservoir models .

computer modelling group

computer modelling group ltd . [ cmg ] | computer modelling group ltd . stock quotes | tmxmoney
is buying computer modelling group ltd ( tsx : cmg ) for its upcoming $ 0 . 1 dividend a good choice ?
computer modelling group ltd functions in the canadian software industry . it specializes in integrated analysis and optimization , black oil and unconventional simulation , reservoir and production system modelling .
all dividends paid by computer modelling group ltd . to holders of common shares in the capital of computer modelling group ltd . will be treated as eligible dividends within the meaning of such term in section 89 ( 1 ) of the income tax act ( canada ) , unless otherwise indicated .
computer modelling group ltd functions in the canadian software industry . it specializes in integrated analysis and optimization , black oil and unconv . . . more
computer modelling group ltd . : cmg - ca : dividend analysis : december 07th , 2017 ( record date ) : by the numbers : december 7 , 2017
computer modelling group ltd . (
cmg
or the
company
) is very pleased to report our financial results for the three and nine months ended december 31 , 2017 .
a sizeable part of portfolio returns can be produced by dividend stocks due to their contribution to compounding returns in the long run . computer modelling group ltd ( tsx : cmg ) has returnedread more . . .
increase in profitability and industry - beating performance can be essential considerations in a stock for some investors . in this article , i will take a look at computer modelling group ltd’s ( tsx : cmg ) read more . . .
computer modelling group ltd ( tsx : cmg ) outperformed the application software industry on the basis of its roe – producing a higher 34 . 78 % relative to the peer average of 16 . 50 % over theread more . . .
the direct benefit for computer modelling group ltd ( tsx : cmg ) , which sports a zero - debt capital structure , to include debt in its capital structure is the reduced cost of capital . however , theread more . . .
computer modelling group is looking for a full - time quality assurance specialist for the visualization group . the qa specialist will perform testing and provide usability feedback related to the hydraulic fracture related functionality in builder , verifying eor ( enhanced oil recovery ) process wizards , as well as provide testing support for the cmost team .
categories : yahoo financeget free summary analysis our analysis is based on comparing computer modelling group ltd . with the following peers – open text corporation , enghouse systems limited , espial group inc . , redknee solutions inc . , constellation software inc . , nexj systems inc . class a and counterpath corporation ( otex - ca , engh - ca , esp - ca , rkn - ca , csu - ca , nxj - ca and cpah - us ) . computer modelling group ltd . ’s dividend . . . read more ( read more . . . )
calgary , alberta , may 24 , 2018 - - computer modelling group ltd . is very pleased to report our financial results for the fiscal year ended march 31 , 2018 . . ebitda is defined as net income before adjusting . . .
on the 15 december 2017 , computer modelling group ltd ( tsx : cmg ) will be paying shareholders an upcoming dividend amount of ca $ 0 . 1 per share . however , investors must have bought the company’s stockread more . . .
calgary , alberta , may 23 , 2018 - - the board of directors of computer modelling group ltd . announces a dividend of $ 0 . 10 per common share on cmg’ s common shares . the dividend will be paid on june 15 , 2018 . . .
london , uk / accesswire / may 9 , 2018 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : kinaxis , computer modelling group , intrinsyc technologies , and absolute software . the tsx venture exchange shaved off 3 . 74 points , or 0 . 48 % , to finish at 770 . 82 . today ' s stocks of interest consist of kinaxis inc . ( tsx : kxs ) , computer modelling group ltd ( tsx : cmg ) , intrinsyc technologies corporation ( tsx : itc ) , and absolute software corporation ( tsx : abt ) .
london , uk / accesswire / june 12 , 2018 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : kinaxis , computer modelling group , intrinsyc technologies , and absolute software . the tsx venture exchange shaved off 6 . 20 points , or 0 . 80 % , to finish at 769 . 02 . today ' s stocks of interest consist of : kinaxis inc . ( tsx : kxs ) , computer modelling group ltd ( tsx : cmg ) , intrinsyc technologies corporation ( tsx : itc ) , and absolute software corporation ( tsx : abt ) .
london , uk / accesswire / march 29 , 2018 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : kinaxis , computer modelling . . .
world ' s leading reservoir simulation software for compositional and unconventional reservoir modelling . read more . . .
the board of directors of computer modelling group ltd . (
cmg
or the
company
) announces a dividend of $ 0 . 10 per common share on cmg ' s common shares . the dividend will be paid on june 15 , 2018 to shareholders of record at the close of business on june 7 , 2018 .
multi - fidelity , multi - disciplinary and collaborative modelling environment for making informed decisions on large integrated oil and gas projects . read more . . .
computer modelling group ltd . (
cmg
or the “company” ) ( cmg . to ) announces that mr . kenneth dedeluk will retire from his position of president and chief executive officer of cmg following the company’s annual general meeting ( “agm” ) on july 12 , 2018 . mr . ryan schneider , currently chief operating officer of cmg , has been appointed by cmg’s board of directors to succeed mr . dedeluk as president and chief executive officer as at the conclusion of the agm and has also been nominated by cmg’s board of directors for election as a director by shareholders at the agm .
london , uk / accesswire / february 28 , 2018 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : espial group , kinaxis , . . .
london , uk / accesswire / january 25 , 2018 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : espial group , kinaxis , . . .
london , uk / accesswire / december 21 , 2017 / active - investors free stock reports for this morning include these toronto exchanges ' equities from the application software industry : espial group , kinaxis , . . .
cmg is a canadian - based computer software technology and consulting company serving the oil and gas industry . we specialize in advanced recovery processes , helping our clients generate greater returns from their oil and gas assets . recognized worldwide as a leading developer of reservoir flow modeling software , cmg has seven sales and technical support offices worldwide to service our blue chip client base of more than 617 international oil companies and technology centers in more than 61 countries .
cmg began in 1978 as a small research company based in calgary , canada . quickly , cmg became known for its expertise in heavy oil , and has expanded this knowledge into all aspects of reservoir flow and advanced processes modelling . since inception , cmg has been providing the ultimate customer experience through our r & d investment , superior technology , and unparalleled user support . today , we are a world - class software technology company with more than 617 oil and gas clients and consulting firms , in 61 countries , using our reservoir simulation tools . our team is at the forefront simulating new recovery methods and developing innovative ways to help you overcome existing technological barriers and reach your strategic goals .
download to access more than 300 new features that deliver faster simulation runs using the industry’s most technically accurate simulation software .
cmg ' s focus on reservoir simulation means we ' re at the forefront in simulating new recovery methods and developing innovative ways to help you overcome existing technological barriers to reach your strategic goals .
our entire organization is focused on reservoir simulation r & d ; , and the subsequent delivery of sound , physics based , technical solutions to the global market .
cmg is the largest ' pure play ' reservoir simulation company in the world . this allows us to
one of the things that sets cmg apart is our entire focus on reservoir simulation research and development , and the delivery of sound , physics based , technical solutions that enable our customers to build models that accurately and reliably represent the recovery process .
cmg reinvests 20 % of its annual revenue back into r & d , which drives advanced reservoir simulation technology forward . more than half of our employees work in r & d , with 50 % of our staff holding a master’s degree or higher qualification . with more than 400 years of combined industry experience , cmg team continuously exceeds our customers’ expectations .
cmg , the leader in enhanced oil recovery simulation , delivers software that is easier to use and provides the most accurate results for compositional , conventional , unconventional and advanced ior / eor processes . cmg software is the industry standard for usability , physics , robustness and performance .
our expert technical sales and support team helps clients 24 / 7 , no matter what time zone you are in . we have a reputation for one - day response rate for technical support questions . in addition , our customers participate in practice - based industry - leading software .
cmg develops market - leading reservoir simulation software , which is recognized worldwide as the industry standard for advanced recovery processes .
cmg ' s superior technology continues to break new ground for capabilities — simulating the simple to the most advanced recovery processes through a combination of easy - to - use model building workflows , state - of - the - art performance enhancement technology and cross - disciplinary multi - physics ( e . g . thermal effects , geochemistry , geomechanics , fluid and phase behavior , wellbore hydraulics and completions ) required to accurately model recovery processes .
a powerful sensitivity analysis , history matching , optimization and uncertainty tool to maximize recovery and npv from all types of reservoirs and recovery processes . read more . . .
model primary and secondary recovery techniques for conventional and unconventional oil / gas reservoirs ; use quick and easy workflows to confidently create forecasts . read more . . .
state - of - the - art visualization & analysis capabilities provides insight into reservoir characteristics , recovery processes and reservoir performance . read more . . .
accurately model the physics of all in - situ recovery processes - thermal , chemical or other advanced eor techniques - to maximize the value and production from an asset . read more . . .
interactive , intuitive and easy - to - use interface enables quick and efficient design and preparation of simulation models for all cmg simulators . read more . . .
create tuned fluid property descriptions for cmg simulators and black oil fluid property data for third - party reservoir simulation software . read more . . .
cmg is always looking for talented , business - minded professionals to join our expanding team . we offer competitive compensation and benefits with opportunities to develop your career . if you are interested in a challenging and rewarding career with us , please check out our current opportunities or forward your resume and cover letter ( ms word or adobe pdf format only ) to human resources . note : by providing your resume to cmg , you are accepting cmg ' s privacy policy . please review it prior to sending your resume . we hold applications / resumes on file for six months . we thank all applicants in advance for their interest . only those chosen for interviews will be contacted .
3710 33 street nw calgary , alberta , t2l 2m1 canada phone : + 1 . 403 . 531 . 1300
please visit our careers page for current job postings . you may submit your resume here . note : resumes will not be accepted by fax .
new delhi , india : + 91 11 4659 . 4019 or + 91 11 4659 . 4012
for inquiries regarding cmg investor relations , or for copies of annual or quarterly reports , please contact us by email or at + 1 . 403 . 531 . 1300
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for inquiries regarding cmg investor relations , dividends or for copies of our annual or quarterly reports and other supplemental information , please contact us by email or at + 1 . 403 . 531 . 1300 .
simulation enables companies to maximize production from their oil and / or gas reservoirs , thereby realizing a direct impact to revenue .
cmg delivers a paradox - fast answers from complex reservoirs with easy - to - use products and workflows . cmg continues to break new ground for simulator capabilities , model building and the refinement of advanced recovery processes . cmg exceeds customer’s expectations , every year .
by focusing on research & development ( r & d ; ) , cmg has created market - leading reservoir simulation software , which is recognized worldwide as the standard for advanced recovery processes .
by remaining focused on reservoir simulation , customers share strategic direction , leading to industry collaboration and the continuous improvement and adoption of cmg software .
by providing unparalleled customer service , cmg has an industry renowned global training and support network that advances knowledge transfer to our customers so they can derive maximum reservoir value and reduce risk through expert use of cmg technology .
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