blood car is a 2007 black comedy film set in the not-too-distant future where gasoline prices have become exorbitant ( $ 30 + us/gallon ) .

things take a turn for the worse when a kindergarten teacher ( mike brune ) invents a car that runs on a different fuel source : blood .

blood car

at just 75 minutes , even a car on blood still runs out of gas .
a schoolteacher struggles to fuel his latest invention : a car that runs on blood .
in the future gas prices are $ 30 a gallon and one man invents a car that runs on human blood .
the aptly - named blood car is a near - future tale about peak oil and bloodthirsty vegans . gasoline is …
' blood car ' is essentially a one - joke scenario that never quite adds up to the sum of its mangled body parts .
we measured the number of car - bcma + cells in the blood of all patients with a qpcr assay that was able to specifically detect car - bcma + pbmcs ( figure 4a ) . although car - bcma + cells could be detected in the blood of all patients , the patients on the lower 2 dose levels had low levels of blood car - bcma + cells , and the patients with the most impressive antimyeloma responses , patients 8 , 10 , and 11 , had the highest peak car - bcma + cell levels . by 3 months after infusion , blood car - bcma + cell levels had decreased to 0 . 1 % of pbmcs or less in all patients .
blood car may have been collecting prizes and earning praise for its supposedly wickedly twisted satire but it still seems trashy , b - movie junk .
the award winning debut feature from director alex orr , the pitch - black comedy blood car mixes surrealist humour , sharp social commentary , kinky sex and buckets of blood . starring anna chlumsky ( best known for her charming starring role in my girl two decades ago ) , mike brune and katie rowlett , blood car is an independent horror - comedy gem that fully deserves to be rewarded with the cult status . blood car ( cert . 18 ) is released by left films and will open at selected cinemas around the uk from 24th february 2012 .
blood car director : alex orr genre : dark comedy dvd street date : march 3 , 2015 dvd srp : $ 19 . 95 dvd upc : 738329162429
autologous peripheral blood mononuclear cells ( pbmcs ) were cultured with an anti - cd3 monoclonal antibody to induce t - cell proliferation . the cells were transduced with the γ - retroviral vector that encoded that car , and 9 days after the initiation of cultures , car - bcma t cells were infused . details of the car t - cell production are in supplemental methods , available on the blood web site .
in the not so distant future , gas prices have skyrocketed to a crushing 30 bones a gallon . the prices forces one good - natured vegan to get creative and find alternate means of fuel but instead of building a car that runs on veggies , he accidentally invents a car that runs on blood . now that ' s the kind of gory thinking they should have used in the death race remake : more blood , less common sense . click through for the full blood car poster and trailer .
the effectiveness of anti - cd19 car t cells against b - cell malignancies encouraged us to develop a car t - cell therapy for multiple myeloma .
publisher ' s note : there is an inside blood commentary on this article in this issue .
message body ( your name ) thought you would be interested in this article in blood journal .
vegan schoolteacher archie is trying to invent an alternative engine that runs on wheatgrass , but when he accidentally cut himself he discovers that all his engine needs to work is blood… human blood . with his blood - fuelled car , archie soon draws the attention of sex - crazed hottie denise , who will do anything for a ride . but government agents are spying on archie , as he is forced into ever more shocking and extreme behaviour to keep his blood car on the road , in this award - winning critically - acclaimed black comedy .
we had a great turn out for our second to last set of feature films for the festival blood car and disarm . both jack hammond of disarm and alex orr of blood car where on hand for the screening and answered audience questions . both movies were very appreciated by the audience and we hope to see both directors again in future festivals .
horizon movies is pleased to announce the dvd release of the cult festival hit blood car , a black comedy — directed by alex orr and starring mike brune , katie rowlett and anna chlumsky — set in a not - too - distant future in which the exorbitant cost of fuel drives one enterprising man to create a car engine that can run on human blood . combining elements of social satire and horror , sight and sound called blood car “a mordant , raunchy and at times gory trip into the dark heart of the american dream” .
see more matte vinyl car wrap silk brown 50ft x 5ft com . . .
with the headline : film ; the brothers coen bow in with ' ' blood simple ' ' .
the vast majority of cases of kidney failure are caused by complications of diabetes or high blood pressure .
in the near future , gas prices are at an astronomical high . one man is determined to find an alternate fuel source . that alternate fuel source turns out to be blood . . . human blood .
matte vinyl car wrap silk brown 50ft x 5ft comes with . . .
veering between wicked social satire and outbursts of hardcore gore , blood car lives up to its reputation as an “audacious , utterly bonkers and downright sick claret - drenched black comedy” ( time out london ) .
26 . 2 marathon runner vinyl decal sticker car window wall bumper running man 13 . 1
in the very near future , no - one can afford to drive any more . fuel prices are at an astronomical high and car parks have become graveyards for abandoned cars . vegan school teacher archie is trying to invent an alternative engine that runs on wheatgrass , but when he accidentally cuts himself he discovers that all his engine needs to work is blood . . . human blood . with his blood - fuelled car , archie soon draws the attention of sex - crazed hottie denise , who will do anything for a ride . but the authorities are already following archie , as he is forced into ever more shocking and extreme behaviour to keep his blood car on the road , in this award - winning critically - acclaimed black comedy .
novartis : car - t results in one month , or no charge . why one month ?
car - bcma t cells became more differentiated after infusion . for a - l , cells from patient 10 are shown . all plots are gated on live lymphocytes , and the numbers on the plots are the percentages of cells in the indicated regions of the plots . staining for car - bcma was performed with pe - bcma - fc . all postinfusion samples were pbmcs that were collected 16 days after car - bcma t - cell infusion . ( a ) cells from the time of infusion ( infusion cells ) were stained for cd3 and car - bcma . ( b ) this plot is gated on the cd3 + car + infusion cells . ( c ) postinfusion cells were stained for cd3 and car - bcma . ( d ) this plot is gated on postinfusion cd3 + car + cells . car t cells after infusion were predominantly cd8 + . ( e ) ccr7 and cd45ra expression of cd3 + cd4 + car + infusion cells is shown . ( f ) ccr7 and cd45ra expression of cd3 + cd8 + car + infusion cells is shown . ( g ) ccr7 and cd45ra expression of postinfusion blood cd3 + cd4 + car + t cells . ( h ) ccr7 and cd45ra expression of postinfusion blood cd3 + cd8 + car + t cells . ( i ) cd3 + cd8 + car + infusion cell pd - 1 and cd28 expression are shown . ( j ) pd - 1 and cd28 expression is shown on postinfusion blood cd3 + cd8 + car + t cells . ( k ) cd57 and cd28 expression on cd3 + cd8 + car + infusion cells is shown . ( l ) cd57 and cd28 expression of postinfusion blood cd3 + cd8 + car + t cells is shown . for m - p , results are shown for all 4 patients with sufficient blood car - bcma + t cells from 7 to 16 days after infusion for analysis . gating and analysis were performed as described above in a - l . the results are all for live cd3 + car + cells . the symbols shown in m correspond to the same patients for m - p . ( m ) the cd8 + to cd4 + ratio of car - bcma t cells increased for all 4 assessable patients between infusion and the time the postinfusion samples were collected . the percentage of cd8 + car - bcma t cells with ( n ) em or emra phenotypes , ( o ) pd - 1 expression , and ( p ) cd57 expression increased in all 4 assessable patients between infusion and the time a postinfusion sample was collected .
car - bcma t cells can eliminate mm cells even when high concentrations of soluble bcma are present in the blood of patients ( figure 4d ) . in addition to being an important finding for car - bcma t - cell therapy , this finding is important because many other promising car target antigens are also present in soluble form in blood and at tumor sites . 45 , 46 serum bcma served as a tumor marker because substantial decreases in serum bcma occurred in the 3 patients with the most impressive antimyeloma responses ( figure 4d ) .
the city alleged contributory negligence based largely on the result on a standard test for blood alcohol . using a blood sample drawn from krall less than an hour after the collision , the test revealed a blood alcohol level of 0 . 159 . the illinois legal limit is . 10 , said defense counsel gregory e . rogus of chicago ' s segal mccambridge singer & mahoney .
when archie and denise are in the car in the beginning of the movie , the car runs out of gas , from a few seconds earlier until that moment you can clearly see outside there is woods , but in the next shot denise get out of the car right in front of a house .
efficacy and toxicity management of 19 - 28z car t cell therapy in b cell acute lymphoblastic leukemia .
the year is the future . you have a car and run people over but it ' s ok because they ' re like zombies or something . evil zombies . evil zombies created in a government - run conspiracy . and only one person can stop them . that person is you . . . and your car . in the end there ' s a plot twist like where you were the zombie all along and stuff but you don ' t know that yet . oh yeah your car is called the blood car ! 2000 !
these results demonstrate for the first time that car t - cells targeting an antigen other than cd19 can induce complete remissions of a hematologic malignancy . importantly , we have shown that car - bcma t cells have powerful activity against mm that was resistant to standard therapies . these results should encourage further efforts to enhance anti - bcma car t cell therapies . the striking activity of anti - bcma car t cells against mm indicates that car t cells targeting bcma have great potential to be an effective new treatment of mm . further development of anti - bcma car t - cell therapies is a very promising area of research .
blood car by alex orr could be termed the anti - grindhouse . it hit all its notes perfectly , nailing and sending up the exploitation genre , with a dose of environmental topicality . in the film ' s wildly inventive plot , an everyman who is tired of rising gas prices and the obscene profits of the oil conglomerates , decides to take matters into his own hands . . . . by building a blood car , a car that runs on blood ( clearly more available than oil ) . in this campy instant cult film , orr mixes buckets - of - blood horror with social commentary and even a little sex for good measure . when our hero falls for the girl of his dreams , he must make a critical decision about how much bloodletting he will do in order to keep his automobile in good running order .
patients with the most impressive antimyeloma responses had the highest levels of blood car - bcma + cells . ( a ) car - bcma + pbmcs were quantified in the blood of patients by qpcr . patients treated on the 2 lower dose levels had low levels of car - bcma + cells in their blood ( left ) . patients treated on the higher 2 dose levels had higher levels of car - bcma + cells in their blood ( right ) . patients 8 , 10 , and 11 had the best antimyeloma responses and the highest levels of blood car - bcma + cells . the results are presented as the absolute number of car + pbmc / μl of blood . pre stands for pretreatment . ( b ) il - 6 was measured in the serum of all patients . patients 10 and 11 ( right ) had the most severe cytokine - release syndrome , and these patients also had the highest serum il - 6 levels . serum il - 6 levels of the other patients are shown on the left . note the different y - axis scales on the left and right graphs . ( c ) five days after car - bcma t cell infusion , serum levels of 15 cytokines were measured in the blood of patient 10 and patient 11 . results are expressed as fold increase over pretreatment levels . ( d ) serum soluble bcma of all patients was measured by elisa pretreatment and posttreatment . the posttreatment serum samples were obtained 22 to 29 days after car t - cell infusion for all patients except patient 12 . the posttreatment sample of patient 12 was obtained 13 days after car t - cell infusion . all patients had detectable serum bcma . in the patients obtaining the most impressive antimyeloma responses , patients 8 , 10 , and 11 , serum bcma decreased posttreatment ( right ) ; in contrast , serum bcma did not decrease substantially posttreatment in the other patients ( left ) .
steven grillo and friends at the
harry potter and the half - blood prince
movie premiere on long island , new york .
and now we have conducted the first - in - humans clinical trial of anti–bcma - car t cells .
lineage switch as a relapse mechanism of pre - b acute lymphoblastic leukemia following cd19 car [ abstract ] .
krall v . city of des plaines - left - turning driver involved in crash with des plaines patrol car .
“it’s the future – like , two weeks from now , ” deadpans a suited government agent direct to camera in blood car ’s opening scene , eating crisps like a cinemagoer as he introduces “a story about a man… about his invention… about society… about you . ”
in a dystopian alternate 1999 , a former cop is forced to take part in a death race in which cars run on human blood as fuel .
paige mcatee at a grocery store at midnight to get
harry potter and the half - blood prince
book on long island , new york .
this rumor claims that a university student in india died from too much co2 in his blood after drinking eight bottles of coca - cola too quickly .
i could probably sum up my entire review of this game by simply referring to it as
like the classic kill car , but actually fun to play .
you basically drive around and run people down , but this game loses the crappy rpg elements of kill car in exchange for blood particle physics and blood decals on the car that make it look like you ' ve just strapped nails to your tires and driven through a playground full of ketchup - filled balloons . you would think that ' s all this game would need , but i wouldn ' t be wording it this way if the rest of the review was all sunshine and butt kissing .
car - expressing t cells targeting the b - cell antigen cd19 can induce lasting complete remissions of b - cell malignancies .
alex orr ' s dark comedy blood car stars mike brune as archie andrews , a mild - mannered elementary teacher attempting to beat the high cost of gasoline ( forty bucks a gallon ) by creating a car that runs on something other than traditional petrol . he makes large purchases of wheatgrass from a young store clerk ( anna chlumsky ) who has a crush on the teacher . however , when he discovers that his new invention runs best on human blood , archie suddenly becomes involved with a woman who does not share his or the store - clerks environmental beliefs . ~ perry seibert , rovi
you might think strange title ? put it in the dvd player , whowwww your in for a treat . very funny titles ie watch this - - - t more of this s - - t , so you know your in for a good time . we have watch it 3 times friends have done the same . the film is about petrol been about $ 15 a gallon , so if you got a car you are quids in with any hot chicks out there . nobody has cars due to this reason . so in comes along a teacher who by mistake invents a fuel to run on blood . so any thing with blood in goes in the boot gets liquidises up and runs the car for a short time . he has a fixation with a girl who loves his car but not him . great one liners , lots blood . serious cult flim . watch twin town aswell .
a naked , blood - soaked man throws a corpse into a dimly lit basement . the cadaver lands against another body . ( source : imdb ) read more »
seattle children’s is now aiming for car - t therapy not for the most desperate cases , but to treat , even cure , kids earlier in the course of the disease . the decision has also left novartis , which is charging $ 475 , 000 per treatment , with no competition for the time being . cripe , chief of the blood cancer and bone marrow transplant division of nationwide children’s hospital in columbus , oh , sees other programs eventually giving doctors more options , especially more cost - effective “off the shelf” car - t therapies that use donor blood cells instead of a patient’s own cells .
toxicities that are mainly caused by cytokines ( cytokine - release syndrome [ crs ] ) also occur after car t - cell infusions .
we chose to focus on improving anti - bcma car t - cell therapies by simultaneously pursuing several different projects . we believe that optimizing car design is currently the most important way to improve car t - cell therapies ; therefore , we are pursuing different projects aimed at finding the optimal design for anti - bcma cars . we are collaborating on a clinical trial of a 4 - 1bb–containing anti - bcma car . for the trial using the cd28 - containing car that is the subject of this report , we decided to administer different doses based on disease burden . because of the toxicities experienced by patients 10 and 11 , we will only administer 9 × 10 6 car - bcma t cells / kg to patients with < 50 % bone marrow plasma cells ; patients with > 50 % bone marrow plasma cells will receive 3 × 10 6 car - bcma t cell / kg . we are also undertaking a preclinical project that will examine the hinge and transmembrane regions of anti - bcma cars , and we are attempting to develop a fully human anti - bcma car .
although the response rates for anti - bcma car t cells against mm reported here are not as high as previous reports of anti - cd19 car t cells against b - cell malignancies , 16 , 17 , 19 , 25 the number of patients treated with anti - bcma cars is quite small . compared with the doses of anti - cd19 car t cells generally required for efficacy and toxicity in our experience ( 1 - 2 × 10 6 / kg ) , 19 higher doses of anti - bcma car t cells ( 3 - 9 × 10 6 car + t cells / kg ) were required to elicit substantial antimalignancy responses and toxicity . this difference could be due to many factors including weaker bcma expression on malignant cells in comparison with cd19 , differences in car design between anti - cd19 cars used previously and the anti - bcma car used in this work , and the presence of soluble bcma in serum and at tumor sites .
the anti - bcma car used in this work ( car - bcma ) incorporated the 11d - 5 - 3 anti - bcma single - chain variable fragment ( scfv ) , a cd28 costimulatory domain , and the cd3−ζ t - cell activation domain ( figure 1a ) . 12 the car sequence was expressed by a γ - retroviral vector backbone used in previous work . 11 , 14 car - bcma was consistently expressed on the surface of transduced cd4 and cd8 t cells , and the transduced t cells proliferated extensively in culture ( figure 1b - c ; supplemental tables 1 and 2 ) . a median of 67 . 0 % ( range , 45 . 3 - 90 . 8 % ) of infusion t cells expressed car - bcma . car - bcma t cells specifically recognized bcma in vitro ( figure 1d ) .
early - phase clinical trials have shown high rates of complete remission ( cr ) after cd19 car - t - cell therapy , even in patients who have failed multiple chemotherapy regimens and / or allogeneic hematopoietic stem cell transplantation ( hct ) . durable remissions can be achieved when functional car - t cells persist sufficiently long to eradicate all malignant cells in the recipient ; however , leukemic relapse may occur with premature loss of cd19 car - t cells or because of the emergence of leukemia that has lost cd19 expression despite persistence of functional cd19 car - t cells .
cd19 - targeted car - t - cell therapy of patients with mll - rearranged b - all effectively induced marrow remission of b - all .
upon its completion , blood car was given a quick and limited dvd release in the u . s . , even as it continued to win acclaim on the international festival circuit . largely overlooked in the states , it was embraced by uk critics as “a slacker take on roger corman movies like the little shop of horrors or death race 2000” ( empire ) . now , seven years later , horizon movies and kino lorber re - introduce blood car to the american viewer in a special new edition , so that this loony yet scathing satire of a gas - guzzling nation on the verge of social collapse can finally gain the domestic notoriety it deserves .
anyone who is interested in detailing a car , cares about their car . who in their right mind would ever think of installing any material that is not built for automotive application ! ? . there is a disconnect with info between what you can use and what you can ' t .
two teddy - bears go hunting unicorns , their favourite prey . unicorns have tender flesh and delicious blueberry - flavoured blood which the bears need to stay cute - looking . read more »
we ' ve shown you footage from blood car before and i ' ve gotta say this looks like a great c - film . especially since it brings my girl ' s anna chlumsky ' s into horror . the flick has been popping up in film festivals across the us , but no wide release date has been announced yet .
both chemotherapy agents were administered daily on days −5 , −4 , and −3 before car - bcma t - cell infusion on day 0 . a single dose of car - bcma t cells was administered to each patient . the dose escalation plan called for an initial dose of 0 . 3 × 10
a schoolteacher struggles to fuel his latest invention : a car that runs on blood . after exorbitant gas prices force average americans to seek alternative fuel sources , archie overlooks his vegan beliefs and starts taking desperate measures to help power his new ride . will either of the two women in his life - butcher stand owner denise or veggie stand owner lorraine ( anna chlumsky ) - end up quenching the blood car ' s thirst ? alex orr ' s clever horror comedy is part christine , part little shop of horrors . one thing ' s certain : you ' ll be glad you ' re safe at home . . . contains strong language , sexual scenes , violence and gore .
loss of normal plasma cells after car - bcma t - cell infusions is an expected toxicity because normal plasma cells express bcma . 12 the low polyclonal immunoglobulin levels of patient 11 show that , at least in some cases , immunoglobulin replacement will be indicated in patients receiving anti - bcma car t cells .
a mosquito falls madly in love with a vampire . together they go looking for fresh blood in a baroque , bizarre and dangerous world . . . ( source : lifff ) read more »
appropriate target antigens for car t - cell therapies should be uniformly expressed on the malignancy to be treated and should not be expressed on normal essential cells .
we demonstrated that car - bcma t cells can eliminate large burdens of treatment - resistant mm . the prior treatment histories of patients 10 and 11 demonstrated the chemotherapy resistance of their mm . prior to enrollment on the car - bcma protocol , patient 10 only obtained a pr after 6 cycles of cybord therapy , and he had 90 % bone marrow plasma cells 3 months after high - dose melphalan and asct . high - dose melphalan is a much more effective antimyeloma therapy than the low - dose cyclophosphamide administered immediately prior to car - bcma t - cell infusions . patient 11 had mm that was refractory to cybord therapy . fludarabine , which was administered prior to car - bcma t - cell infusions , has been shown to have essentially no activity against mm . 42 all in all , the antimyeloma responses after car - bcma infusion in patients 10 and 11 cannot be attributed to the chemotherapy administered prior to car - bcma t - cell infusions .
blood car is set to street on dvd march 3 , with a srp of $ 19 . 95 . the disc comes packed with bonus features including two shorts from the fake wood wallpaper film collective , “the adventure” ( 2008 , 21 min . ) and “the $ 100 short short” ( 2006 , 10 min . ) as well as the theatrical trailer .
patients with mll - rearranged b - all who attain cr after cd19 car - t - cell therapy may be at risk for relapse with clonally related aml .
a bodybuilder , extraterrestrials , kidnapping , 40 gallons of blood—this is a beautiful , sometimes silly trip shot in spain in stunning black & white . ( source : new orleans film society ) read more »
for all 12 patients , the median ratio of cd8 + to cd4 + car + t cells in the infusion cells was 1 . 1 ( range , 0 . 3 - 10 . 9 ; supplemental table 4 ) . sufficient car - bcma t cells were available for a phenotypic analysis of blood t cells from 4 patients after infusion ( figure 5 ) . among these 4 patients , the median ratio of cd8 + to cd4 + car + t cells in the infusion cells was 0 . 9 . in contrast , the persisting car + t cells in the blood of the same patients after infusion were mainly cd8 + t cells with a median cd8 + to cd4 + ratio of 28 . 8 ( range , 2 . 5 - 60 . 9 ; figure 5m ) . the expression of c - c chemokine receptor type 7 ( ccr7 ) and cd45ra is used to divide t cells into 4 categories : naïve , central memory ( cm ) , effector memory ( em ) , and effector memory ra ( emra ) . compared with naïve and cm t cells , em and emra t cells are more differentiated with less proliferative potential . 38 ccr7 and cd45ra expression data of the infusion car - bcma t cells of all patients are in supplemental tables 5 and 6 . programmed cell death protein - 1 ( pd - 1 ) is an inhibitory t - cell receptor important in t - cell exhaustion . 39 cd57 is a marker of highly differentiated t cells with reduced proliferative capacity . 40 , 41 in the 4 patients with sufficient car + t cells for phenotypic analysis of blood t cells after infusion , car t cells acquired a more differentiated phenotype with an increase in em and emra t cells after infusion ( figure 5n ) . increases in expression of pd - 1 and cd57 provided further evidence that car - bcma t cells acquired a highly differentiated phenotype after infusion ( figure 5o - p ) .
this is a decent comedy horror that has a unique premise , but could have been done better . the idea of the film is quite good , and the creative aspect is sure to delight horror fans looking for an amusing , mindless film to watch . however , i felt that blood car could have benefitted from a few rewrites as the concept is very good , but it does fall short of what the film could have been . the problem with the film is that it tries to rush things while trying to grab your attention . if this would have been a slightly longer feature , with a bit more depth to its sheer ridiculous plot , then blood car would really have been a great horror comedy . however it does fall short . i ' m not saying it ' s a bad film , but it ' s a film that needed some improvements . despite its imperfections , this is somewhat enjoyable for what it tries to accomplish , and viewers looking for a fun , entertaining low budget b movie , will most likely enjoy this low budget affair . blood car could have been better , but for what it is , it ' s a decent film worth seeing if you love ridiculous horror films . for the most part , blood car works , but there are better b movies out there . i really liked the concept ; i simply wished that the filmmakers would have made the film a bit longer , in order for the story to have a nice flow . as it is , it ' s a rushed film , one that doesn ' t reach its full potential and it ' s a shame because blood car could really have stood out . this is a decent film , but there is nothing remarkable about this b movie , but it ' s worth checking out if you have nothing else better to watch .
a young girl wakes up in the trunk of a car . this is not how she imagined her birthday . . . ( source : imdb ) read more »
within 1 month you will receive a free car . a draw has just been concluded in hong kong last weekend ( we contacted you via your email address ) .
during the first week after car - bcma infusion , we noted a striking decrease in patient 10’s serum iga level ( figure 2g ) . serum iga became undetectable and remained undetectable 14 weeks after car - bcma t - cell infusion . a dramatic eradication of mm from the bone marrow occurred . ihc for the plasma cell marker cd138 showed a complete absence of bone marrow plasma cells 4 and 8 weeks after car - bcma t - cell infusion ( figure 2e - f ) . four weeks after car t - cell infusion , a population of t cells was detected in the bone marrow ( figure 2h ) ; 31 % of bone marrow t cells expressed car - bcma by flow cytometry ( figure 2i ) . the serum and urine immunofixation electrophoresis tests for monoclonal iga - κ became negative after treatment and remained negative 14 weeks after car - bcma t cell infusion . fourteen weeks after car - bcma t - cell infusion , multicolor flow cytometry did not detect mm cells in the bone marrow , which confirmed a stringent complete remission ( cr ) . as expected , normal plasma cells were also absent from the bone marrow 14 weeks after car - bcma infusion . nineteen weeks after infusion , the serum immunofixation electrophoresis remained negative , but a monoclonal iga - κ protein was detected in the urine . this indicated a relapse of mm . subsequently , bcma + malignant plasma cells were detected in the bone marrow ; car - bcma t cells were not detected in the bone marrow at the time of relapse .
after receiving cd19 - targeted car - t cell therapy , all patients with mll - b - all achieved cr in the marrow by flow cytometry ; however , 2 of 7 patients relapsed , both with a myeloid phenotype leukemia approximately 1 month after car - t cell infusion . pathology findings are summarized in table 1 and figure 1 .
patient 10 experienced pancytopenia associated with a hypocellular bone marrow ( figure 2e ) . he had an absolute neutrophil count ( anc ) of 370 immediately before the car - bcma t - cell infusion . the anc remained < 500 for 40 days after car - bcma t - cell infusion , and the patient had an episode of bacteremia associated with transient hypotension during this neutropenic period . the patient also experienced transfusion - dependent thrombocytopenia for 9 weeks after car - bcma infusion . fourteen weeks after car t - cell infusion , patient 10 had a normal anc , and he had not required a platelet transfusion in > 6 weeks , although his platelet count remained decreased at 43 000 / μl .
it ' s inspiring to see films like this every once in a while - hyper low - budget triumphs of the indie spirit . occasionally hilarious and usually entertaining , except for a few kind of boring patches , blood car is an entertaining testament to the successes that independent film making can produce . it ' s one of those movies that makes you want to go out and film your own .
car - bcma t cells specifically recognized bcma in vitro and exhibited antimyeloma activity in humans . ( a ) diagram of the msgv - 11d5 - 3 - cd828z γ - retroviral vector encoding the anti - bcma car ( car - bcma ) is shown . car - bcma contained the 11d5 - 3 anti - bcma single chain variable fragment ( scfv ) , cd8α hinge and transmembrane regions , the cytoplasmic portion of the cd28 costimulatory moiety , and the cd3ζ t - cell activation domain . ( b ) car - bcma expression on the surface of the infusion t cells of patient 10 was detected by staining with a pe - bcma - fc protein reagent . the plot is gated on live cd3 + lymphocytes . ( c ) demonstrating specificity , the pe - bcma - fc reagent did not stain pbmcs that were not transduced with the car - bcma gene . ( d ) car - bcma t cells of patient 10 were cultured with target cells that either expressed bcma ( bcma - k562 and rpmi8226 ) or did not express bcma ( ngfr - k562 and ccrf - cem ) . the car - bcma t cells of patient 10 specifically released ifnγ in response to bcma - expressing target cells in vitro . ( e ) patient 8 who had mm that was progressing despite 8 prior lines of therapy obtained a very good partial remission ( vgpr ) after infusion of car - bcma t cells . positron emission tomography–computed tomography scans from before and after treatment show elimination of a large number of mm bone lesions . ( f ) patient 8’s free κ light chains level decreased after car t - cell infusion as the mm entered a vgpr and then increased with progression of the mm . the serum bcma protein level followed a pattern similar to that of the serum free κ light chains .
administration of lymphodepletion chemotherapy followed by cd19 - specific chimeric antigen receptor ( car ) –modified t cells is a remarkably effective approach to treating patients with relapsed and refractory cd19 + b - cell malignancies . we treated 7 patients with b - cell acute lymphoblastic leukemia ( b - all ) harboring rearrangement of the mixed lineage leukemia ( mll ) gene with cd19 car - t cells . all patients achieved complete remission ( cr ) in the bone marrow by flow cytometry after cd19 car - t - cell therapy ; however , within 1 month of car - t - cell infusion , 2 of the patients developed acute myeloid leukemia ( aml ) that was clonally related to their b - all , a novel mechanism of cd19 - negative immune escape . these reports have implications for the management of patients with relapsed and refractory mll - b - all who receive cd19 car - t - cell therapy .
in a near future where gasoline costs more than $ 30 a gallon , schoolteacher archie andrews invents an engine that runs on human blood . needless to say , complications arise when his revolutionary creation requires fresh supplies of fuel .
patients received lymphodepletion chemotherapy , followed by infusion of autologous cd19 car - t cells , according to 2 clinical trial protocols ( nct01865617 , nct02028455 ) . t cells were modified using a car construct incorporating a truncated human epidermal growth factor receptor as a marker of transgene expression , which enabled enumeration of car - t cells . 8 evaluation of leukemic blasts by flow cytometry , fluorescence in situ hybridization ( fish ) , g - banded karyotyping , and chromosomal genomic array testing ( cgat ) was performed in clinical laboratory improvement amendments–certified laboratories , and deep sequencing of the igh gene was performed by adaptive biotechnologies ( seattle , wa ) . quantitative polymerase chain reaction for vector sequence was used to enumerate integrated car transgene in car - t cells and myeloblasts . these studies were conducted with approval of the institutional review boards of fred hutchinson cancer research center and seattle children’s hospital and in accordance with the declaration of helsinki .
he sandal was reportedly found in 2012 at the site where konstantinos
dino
barkas was - operating a digger , while the car was - discovered last year at another spot .
so , with this flagrant breach of both chronological logic and the fourth wall , blood car immediately establishes its absurdist tone . alex orr’s feature debut was in fact completed in 2007 , winning acclaim and awards at various festivals before going straight to dvd in the us – but in the half decade that it’s taken to get its theatrical release in the uk , the film has left its influence on quentin dupieux’s left - field ‘road movie’ rubber and dean francis’s more conventional highway horror road train ( both 2010 ) , the former similarly featuring a killer car part , the latter a carnivorous engine .
we detected soluble bcma in the serum of all 12 patients before treatment ( figure 4d ) . serum bcma decreased after car - bcma t - cell infusion in the patients with the most impressive antimyeloma responses , patients 8 , 10 , and 11 ; in contrast , serum bcma did not decrease substantially after car - bcma t - cell infusion in the other patients .
six civilian witnesses testified that the overhead lights on officer neubauer ' s car were not turned on , while three city police officers , including neubauer , testifies that the lights were operating .
all patients experienced cytopenias attributable to the conditioning chemotherapy that patients received on this protocol and the extensive prior therapy patients had received before protocol enrollment ; patients 10 and 11 had cytopenias clearly more prolonged than expected from the chemotherapy that they received . toxicities are listed in table 2 . toxicities attributable to car - bcma t cells were minimal in patients treated on the 0 . 3 × 10 6 car + t cells / kg dose level . on the 1 × 10 6 car + t cells / kg dose level , patients 4 and 5 had signs and symptoms of crs including mild fever and tachycardia . patient 8 had significant fever , tachycardia , and hypotension among other toxicities , but the 3 other patients receiving 3 × 10 6 car + t cells / kg had mild toxicity . on the 9 × 10 6 car + t cells / kg dose level , patients 9 and 10 both had a variety of grade 3 and 4 toxicities .
when the transplant failed about three months later , “we thought it was a death sentence , ” says andy . but greta qualified for experimental car - t therapy , available only to patients with no other recourse . in august 2014 she received a dose of her own t cells , extracted from her blood , modified and expanded outside her body , then infused back into her bloodstream to zero in on the life - threatening cancer .
greta and charlotte were chattering in the back seat of the family car when i spoke to her parents recently . they were driving from their home in portland to a weekend vacation in canada .
to receive your free car all you need to do is send us your 1 . full name 2 . address / contact number 3 . country of origin 4 . occupation 5 . email .
patient 11’s serum igg - λ m - protein started to decrease after car - bcma t - cell infusion and decreased to the point that it was not quantifiable at last follow - up 28 weeks after car t - cell infusion . the only evidence of mm at last follow - up was the serum igg - λ m - protein that was detectable only by immunofixation electrophoresis . the serum free λ light chains that were another marker of the patient’s mm became undetectable early after treatment ( figure 3g ) . patient 11’s most recent formal myeloma response was vgpr . a bone marrow biopsy 4 weeks after the car t - cell infusion revealed a hypocellular bone marrow and complete elimination of bone marrow plasma cells ( figure 3e ) . the patient was platelet transfusion dependent from day 2 until day 27 after car t - cell infusion . eight weeks after the car t - cell infusion , bone marrow cellularity was recovering , and plasma cells remained completely absent ( figure 3f ) . absence of mm cells and normal plasma cells from the bone marrow was confirmed by multicolor flow cytometry 4 , 8 , and 25 weeks after car t - cell infusion . four weeks after car t - cell infusion , a large population of t cells was detected in the bone marrow ( figure 3h ) ; 19 % of bone marrow t cells expressed car - bcma by flow cytometry ( figure 3i ) . less than 8 weeks after the car t - cell infusion , all of patient 11’s toxicities except decreased lymphocyte count had improved to grade 1 or resolved , and he had returned to full - time employment . in accordance with continued absence of plasma cells in patient 11’s bone marrow , the serum immunoglobulin levels steadily decreased after car - bcma infusion . twenty - eight weeks after car t - cell infusion , the serum igg was 388 mg / dl ( normal range , 700 - 1600 mg / dl ) , the serum iga was below detectable limits , and the serum igm was 15 mg / dl ( normal range , 40 - 230 mg / dl ) . because of the low immunoglobulin levels , we initiated immunoglobulin replacement with intravenous igg .
' ' blood simple ' ' contains much blood and gore , and the coens say they are surprised the critics haven ' t taken them to task for the violence . ' ' but the violence is bound up in the story , rather than gratuitous , ' ' joel said . ' ' it ' s very different from a horror movie where the characters are mechanically set up to be slaughtered . we have no slasher scenes . this is more of a story movie . ' '
making the most of his low budget and fully embracing a b - picture sensibility , orr loads his film with broad caricatures , low humour and hilariously surreal ( and politically incorrect ) digressions . but this is an exploitation movie about exploitation , and its disarming goofiness and transgressive vulgarity eventually give way to images of state execution and infanticide – all in the name of the american dream – that are shockingly serious , if still played for uncomfortable laughs . a speech of frankly insane justification delivered by another government agent ( matt hutchinson ) near the film’s end evokes dr . strangelove ( 1964 ) – and indeed blood car is similarly apocalyptic in its lampooning of post - millennial anxieties , with a gleefully cynical finale pointing to a dead - end future for all but a self - serving political elite . a couple more weeks down the road , blood car will be a cult classic .
this rumor has taken on many forms , claiming that coca - cola , due to its acidic nature , can be used to clean toilets and corrosion from car batteries , loosen a rusted bolt and remove rust spots from car bumpers , remove grease from clothing , clean road haze from windshields , clean highways after traffic accidents , cook a steak , dissolve teeth , and bake a moist ham .
but the novartis car - t wasn’t what cured greta . she was too young at the time to enter the experimental trial for that program . instead , her parents enrolled her in a study for a different car - t program , at seattle children’s hospital , which was accepting patients as young as a year old . greta ( pictured above , with her sister charlotte , 6 , behind her ) first had to put on weight—lots of french fries and milkshakes , says her mother , maggie—then go through another round of chemo , but she managed to hang on for her car - t treatment .
progression of bcma - negative mm is a potential problem after car - bcma t - cell therapies . we assessed bone marrow mm cells for bcma expression after car - bcma t - cell infusion by ihc ; the before and after treatment bcma expressions are summarized in supplemental table 4 . a partial loss of bcma expression by malignant plasma cells was detected only in patient 7 ( supplemental figure 1 ) .
the city of des plaines alleged that debra krall was under the influence when she made a left turn into the path of a police car driven by officer lori neubauer on sept . 23 , 1995 .
patient 11 received 5 prior lines of therapy before enrolling on the car - bcma protocol . his most recent therapy prior to enrollment was cybord ; during his only cycle of this treatment , patient 11’s mm progressed . before car - bcma infusion , 80 % of the cells in the patient’s hypercellular bone marrow were bcma + plasma cells ( figure 3a , b , d ) . four hours after infusion of 9 × 10 6 car - bcma t cells / kg , he developed a sustained fever that was associated with an elevated crp ( figure 3c ) . worsening tachycardia , hypoxemia , and dyspnea developed over the next day , so 25 hours after the car t - cell infusion , tocilizumab was administered . this patient also had grade 3 delirium without other neurologic toxicities . four hours after the tocilizumab was administered , the dyspnea improved , and the temperature and heart rate decreased temporarily . a second dose of tocilizumab was administered 5 days after the car t - cell infusion . patient 11 had adrenal insufficiency at the time of protocol enrollment , and he received stress - dose intravenous hydrocortisone at doses varying from 25 to 75 mg every 8 to 12 hours between day 0 and day 13 after car t - cell infusion .
car - bcma t cells were detected by flow cytometry after staining with a phycoerythrin - labeled bcma constant - fragment reagent ( pe - bcma - fc ) ( figure 1b - c ) . car - bcma t cells were also detected by performing quantitative pcr ( qpcr ) . enzyme - linked immunosorbent assays ( elisa ) for interferon γ ( ifnγ ) were performed on supernatants from cultures of car - bcma t - cell samples plus target cells . interleukin - 6 ( il - 6 ) elisas , soluble bcma elisas , and multicytokine assays were performed on patient serum . methods for all assays are in supplemental methods .
garry shandling died from a blood clot , tmz reported on tuesday after it obtained a copy of the comedian’s autopsy report . the outlet said that shandling also had xanax , hydrocodone and oxycodone in his system at the time , attributed to a recent dental surgery .
when i say
two of three bonus levels i saw ,
that ' s because i couldn ' t get very far in the game . i couldn ' t find a certain npc on the second level which spans the entire city and i ultimately decided i wasn ' t willing to put up with the hide - and - seek games , indestructible obstacles , and crappy car physics to find how many more inventive parallels the developers decided to draw between blood and feces .
immunotherapy with t cells that are genetically modified to express a cd19 - specific chimeric antigen receptor ( car ) represents a promising approach for patients with refractory b - cell acute lymphoblastic leukemia ( b - all ) .
we have previously shown that anti - cd19 car t cells administered without chemotherapy can cause cytopenias in patients with high disease - burden all . 23 of the patients receiving car - bcma t cells , patient 10 experienced prolonged pancytopenia and patient 11 experienced prolonged thrombocytopenia . we hypothesize that the cytopenias experienced by these 2 patients were a cytokine - mediated phenomenon caused by high levels of cytokines produced when car - bcma t cells contacted high burdens of bone marrow mm ; however , bystander perforin / granzyme - mediated killing of hematopoietic cells could also be speculated . both of these patients were cytopenic prior to car - bcma t - cell infusion , which probably contributed to the severity of the cytopenias after car - bcma t - cell infusion ( supplemental table 7 ) . the chemotherapy that patients received as part of this protocol is expected to cause cytopenias , and the extensive therapy that the patients had received prior to protocol enrollment probably contributed to chronic bone marrow impairment in some patients . we never observed bcma expression on any bone marrow cells except plasma cells after performing ihc staining on bone marrows from 85 patients .


spike is a 2008 horror-romance directed by robert beaucage , produced by string and a can productions , and starring edward gusts , sarah livingston evans , anna-marie wayne , nancy p. corbo , and jared edwards .

the film has been described by robert hope as " angela carter rewriting la belle et la bête as an episode of buffy the vampire slayer . "

spike ( 2008 film )

- episode dated 8 january 2008 ( 2008 ) . . . himself - guest
- episode dated 10 may 2008 ( 2008 ) . . . himself - guest
thomson - jones , kathryn , 2008 . aesthetics and film , london : continuum .
- denzel washington / george clooney / clint eastwood ( 2008 ) . . . himself
––– , 2008 . the philosophy of motion pictures , malden , ma : blackwell .
was presented by spike jonze and david fincher , two friends of tarsem . ( spike jonze directed videos for the beastie boys ,
livingston , paisley , and carl plantinga , 2008 . the routledge companion to philosophy and film , abingdon : uk : routledge .
sugarland – all i wanna do music video ( mercury records ) apr 2008 on oahu .
- the lord of the rings and the two towers ( 2008 ) . . . gollum
- the dickensian aspect ( 2008 ) . . . det . james ' jimmy ' mcnulty
skate videos were spike jonze’s “gateway drug” to the world of movie - making . in this 2008 interview , the being john malkovich director and other skate - film legends discuss the enduring importance of the underground scene
the informant ( warner brothers ) feature film about a high - level agribusiness exec turned whistle blower . starring matt damon . june 2008 on oahu .
a documentary film about fifteen young sailors vying to win the famous trans - pacific sailing race , and the struggles they encounter . aug 2008 on oahu .
mariah carey – i’ll be loving u long time music video features rapper t . i . jun 2008 on oahu
germany’s answer to the popular series , america’s next top model . hosted by heidi klum . 2008 on oahu .
( 2008 ) . he has been married to catherine fitzgerald since june 26 , 2010 . they have four children .
among his many credits , vincent appeared in spike lee’s do the right thing and jungle fever and played a detective in the 2008 indie the tested . he had a cameo role in 2009’s stargate atlantis .
eisenstein , sergei , 1969 . film form : essays in film theory , new york : harcourt .
wedding day ( tnt ) reality series where a couple is given the wedding of their dreams . sep 2008 on maui .
copyright 2008 the associated press . all rights reserved . this material may not be published , broadcast , rewritten or redistributed .
director spike lee at the oscars in hollywood in february . photograph : lucas jackson / reuters
reality television series that reunites a group of high school classmates for the first time in 20 years . jul 2008 on maui .
hannity : i ' m asking you about spike lee , who made an accusation about clint eastwood , because he portrayed it accurately in the film .
' we ' re not on a plantation , clint . ' spike lee hits back in war of words over black soldiers | film | the guardian
i went to the spike tv scream 2008 awards and have plenty of things to report back from it . first off , here’s a story i wrote that was published on the front page of the los angeles times this morning .
vincent was among the sopranos cast when the show received the 2008 sag award for outstanding performance by an ensemble in a drama series .
hannity : spike lee — i ' m asking you if he — spike lee plays the race card continually . i ' m asking you , if you have the intellectual honesty to admit it .
tags anna - marie wayne edward gusts jared edwards nancy p . corbo robert beaucage sarah livingston evans spike
a documentary series following the life of actress denise richards . airs sunday at 10 : 30 / 9 : 30c . apr 2008 on oahu .
ledger , who began his screen career in aussie tv shows sweat and roar in the mid 1990s , died in new york in january 2008 .
hannity : and do you think when spike lee said he was overrated because of his race . . .
entourage ( hbo ) television series about a hollywood superstar and his group of friends . starring jeremy piven and kevin connolly . apr 2008 on oahu .
clint eastwood has advised rival film director spike lee to
shut his face
after the african - american complained about the racial make - up of eastwood ' s films .
knight rider ( nbc ) updated version of the hit 80’s television series about a man and his car . starring val kilmer . oct 2008 on oahu .
colmes : well , no , it is the issue . he was criticized by spike lee for that , saying a white guy shouldn ' t have made that film . spike lee could have made that film , as well , and he employed 90 percent african - american actors in that film . to suggest clint eastwood somehow does not care to employ african - american actors , which is the implication here , is wrong .
do yourself a favor , if you decide you want to know more about the film “spike : a gothic fairy tale” , do not go to youtube and look up the trailer .
in march 2008 , jonze turned in a revised script . he hadn’t made major changes — he’d removed one scene and added two — but warner brothers acquiesced , giving him the money he needed to finish the film . “we felt that the changes spike made in the movie really addressed the majority of the issues , ” robinov told me .
illinois film officials won’t say whether lee’s film tax credits included a location fee for st . sabina . lee didn’t respond to emails .
his most famous role is baltimore commissioner ervin h . burrell , which he played on the critically acclaimed hbo series
the wire
from 2002 - 2008 .
a born director . a fearless actor . an unforgettable artist . i am heath ledger premieres may 17th on spike .
this is a rush transcript from
hannity & colmes ,
june 9 , 2008 . this copy may not be in its final form and may be updated .
wheel of fortune ( sony pictures television ) the iconic game show filmed 20 episodes in hawaii . starring pat sajak and vanna white . sep 2008 on big island .
tan , ed s . , 1995 . emotion and the structure of narrative film : film as an emotion machine , london : routledge .
“why won’t they show you the numbers ? i think they would be embarrassed by the numbers , ” says former state sen . rickey “hollywood” hendon , d - chicago , who sponsored the illinois film production services tax credit act of 2008 .
' a guy like him should shut his face ' - clint eastwood on spike lee . photograph : nicolas guerin / corbis
' we ' re not on a plantation , clint . ' spike lee hits back in war of words over black soldiers
new york  spike lee will film passing strange , stew ' s rock musical journey of self - discovery , during performances next week at broadway ' s belasco theatre , it was announced wednesday .
into the blue 2 : the reef ( mgm home entertainment ) straight to video feature film about a pair of professional divers who are hired to find columbus’ hidden treasure . starring chris carmack and laura vandervoort . may – jun 2008 on oahu .
this entry is organized around a number of issues that are central to the philosophy of film . they explore different aspect of film as an artistic medium , illustrating the range of concerns addressed within the philosophy of film .
special delivery ( lifetime ) television movie about a bonded courier who transports a bratty teenager on an international flight . starring lisa edelstein and brenda song . feb 2008 on oahu .
australia’s biggest loser : season 3 ( fremantlemedia australia ) a reality television series profiling a group of people as they compete to lose the most weight . feb 2008 on oahu .
the amazing race ( cbs ) a reality television series following teams of 2 on an international race around the world for half a million dollars . nov 2008 on oahu & kauai .
an article on sept . 6 about the film director spike jonze omitted a credit for the illustrations . they were by geoff mcfetridge , who also did the illustrations for the type about jonze on the cover .
hannity : spike lee ,
he ' s overrated because of his race . you listen to the white media . . .
for spike lee and members of his cast , & apos ; chi - raq & apos ; was a big , honking curveball .
heath ledger was an academy award - winning , australian actor best known for his roles in brokeback mountain and the dark knight . he died of an accidental prescription drug overdose in 2008 .
her character never once leaves her apartment during the entire course of the film .
hannity : spike lee ,
trent lott is card - carrying member of the ku klux klan .
is that acceptable , leo ?
life and business coach kimyon zari joins us tonight . start your week with powerful motivation . spike spillberg live from the director ' s chair
honoka’a boy ( fuji tv ) based on a true story , this feature film is about a young japanese boy who comes to honoka’a on the big island and becomes the projectionist at the honoka’a people’s theater . starring masaki okada . oct – nov 2008 on big island .
flirting with forty ( lifetime ) television movie about a divorced mother who falls for a younger man while on vacation . starring heather locklear and robert buckley . apr – may 2008 on oahu .
spike jonze , the director with the childlike imagination , and the actor max records . ( jonze is the one without a wolf suit . )
spike lee , director of
chi - raq
during a media availability at the waldorf astoria in chicago on nov . 23 , 2015 .
in order to justify the claim that film deserves to be considered an independent art form , philosophers investigated the ontological structure of film . the hope was to develop a conception of film that made it clear that it differed in significant ways from the other fine arts . for this reason , the question of film ' s nature was a crucial one for theorists of film during what we might call the classic period .
––– , 2007 . thinking on screen : film as philosophy , london : routledge .
the first trailer for the film about the late australian star was unveiled earlier this month along with news it would premiere at new york’s tribeca film festival this coming weekend .
before his unfortunate passing , heath ledger completed filming the dark knight , and the blockbuster that was rumored to have been heath ledger & apos ; s oscar winning performance opened in u . s . theaters on july 18 , 2008 . the film grossed more than $ 400 million in 18 days .
the problem is that the sub - field of film theory within film studies has been dominated by a range of theoretical commitments that many anglo - american philosophers do not share . many such philosophers have therefore felt a need not just to make minor revisions in the field and its understanding of film but rather to make a new beginning in the study of film that does not share the problematic assumptions of film theory itself . for this reason , as well as the earlier - cited view of film as a legitimate topic within aesthetics , they have felt it important to develop a philosophically informed mode of thinking about film .
hannity :
. . . and nobody ever played basketball before him .
that ' s your — that ' s your friend , spike lee .
hannity : let me raise it up a notch . your friend spike lee ,
shoot charlton heston .
you want to defend that , leo ?
arnheim , rudolf , 1957 . film as art , berkeley : university of california press .
( 2012 ) , the eponymous king kong in the 2005 film , caesar . . .
the best spike lee movie and the best 9 / 11 movie and the best new york movie of the last fifteen years . the competition on all three fronts is sadly weak but i’m not damning with faint praise ; this is a great film .
the debates about what the philosophy of film should look like are really just being joined . this is because it is only recently that a scientific conception of the philosophy of film has emerged as a competitor . but despite the increasing popularity of a cognitive approach to film , there are fundamental issues about the structure of the philosophy of film that remain to be settled .
jennifer hudson at the world premiere of spike lee ' s
chi - raq
at the chicago theatre on nov . 22 , 2015 , in chicago .
this spike lee film examines the life of an aspiring actress in new york . she is upset by the treatment of women in the movie industry during one of her screen tests with ' qt ' . out of work . . . see full summary »
still , there are some reasons why it might seem problematic for there to be a separate academic field of the philosophy of film . because the study of film is already institutionalized within academia in the discipline of film studies , and because that field includes a separate sub - field of film theory , it might seem that , unlike literature and music , say , film is already well - served by this institutional base . from this point of view , the philosophy of film is redundant , occupying a space that has already been carved out by an alternative discipline .
director spike lee ' s passionate adaptation of the thrilling broadway musical about a young bohemian who experiences sex , drugs and rock and roll on his journey to selfhood .
illustration from maurice sendak ' s children ' s book
where the wild things are .
photo of max records from the film version of
where the wild things are
from warner bros . photo of spike jonze by francois guillot / afp getty images
jon & kate plus 8 : season 4 ( tlc ) a documentary series following the lives of a couple as they struggle to raise a set of twins and sextuplets . airs mondays at 9 / 8c . 2008 on maui .
bryan appleyard has argued compellingly for man on wire ( 2008 ) as the “most important” 9 / 11 film . for appleyard , james marsh’s documentary account of philippe petit’s tightrope walk between the towers in 1974 – precisely by not mentioning the towers – affects an “anticipatory sadness and nostalgia for a pre - 9 / 11 world” .
ranciere , jacques , 2006 . film fables ( talking images ) , london : bloomsbury academic .
sinnerbrink , robert , 2011 . new philosophies of film : thinking images , london : continuum .
state officials won’t say whether they’ve ever rejected an application for film tax credits for any reason .
q : what ' s happening ? a lot of the film doesn ' t make sense .
i am heath ledger , a feature - length documentary celebrating his life using footage he had filmed himself , was released in theaters and aired on spike in may 2017 .
this idea of modeling the discipline of the philosophy of film on the natural sciences has been prominent among cognitive film theorists ( bordwell and carroll 1996 ; currie 1995 ) . this rapidly developing approach emphasizes viewers ' conscious processing of films , as opposed to the emphasis within traditional film theory on unconscious processes . in general , these theorists lean towards seeing the study of film as a scientific undertaking .
the oscars present hollywood as it wishes to be — refined , glamorous and high - minded — but on saturday night at the greek theatre , the spike tv scream 2008 awards showed the movie industry as it truly is in 2008 : obsessed with superheroes , overflowing with fake blood and relentless in its pursuit to sell popcorn to teenagers . and despite a name that sounds like a b - movie convention , the scream awards turned out to be so of - the - moment in their target audience that top studio executives , major stars and a - list directors not only attended , they talked backstage about the show as a sign of the times .
the philosophy of film has become a significant area for philosophical and aesthetic research . philosophers have concentrated both on aesthetic issues about film as an artistic medium — the philosophy of film — and questions about the philosophical content of films — films as philosophy . the sophistication and quantity of contributions in both of these areas continue to increase , as more philosophers have taken film seriously as a subject for philosophical investigation .
carroll , nöel , 1988 . philosophical problems of classical film theory , princeton : princeton university press .
jarvie , ian , 1987 . philosophy of the film , new york : routledge & kegan paul .
the acrimonious feud between two of hollywood ' s best - known film directors reached a new level of name - calling and accusation at the weekend as spike lee invoked america ' s bitter legacy of slavery in response to clint eastwood ' s comments to the guardian on friday .
hannity : i agree . and spike lee or clint , maybe one day , should do a movie on it . but that ' s not what this movie was about .
d . b . sweeney at the world premiere of spike lee ' s
chi - raq
at the chicago theatre on nov . 22 , 2015 , in chicago .
festive children ' s animation following the adventures of a young elf who graduates to santa ' s workshop . unfortunately , as hard as spike tries , he struggles to adapt to life in the workshop and cause no end of trouble . from the award winning producer of jungle bunch , spike is the amazing story of how a little elf save christmas .
© 2018 spike cable networks inc . all rights reserved . paramount network and all related titles and logos are trademarks of paramount pictures . viacom is a trademark of viacom international inc .
the topic of film narration thus continues to be a subject of intense philosophical discussion and investigation . various attempts to explain its nature remain hotly debated . as new and more complex styles of film narration become popular , it is likely that the subject of film narration will continue to receive attention from philosophers and aestheticians .
philosophers working in the continental tradition have advocated a more sweeping account of film ' s contribution to philosophy . indeed , the term
film - philosophy
has been introduced to refer to the allegedly new form of philosophizing that takes place on film . ( see sinnerbrink 2011 for a discussion of this idea . )
he acquired the rights to the film , and , he said , “i started to collect visuals . ”
is there any need for a separate philosophic discipline devoted to film in addition to more empirical studies of film undertaken under the aegis of film studies itself ? although this question has not always received the attention it deserves from philosophers , it is actually a pressing one , for it asks philosophers to justify their newly found interest in film as more than an opportunistic incorporation of a highly popular form of popular culture into their domain .
this stretching of the concept
film
to include both non - celluloid movies and television and other related mediums has led some philosophers of film to suggest replacing the term
film
with a broader category , such as moving picture or moving image . so far , such suggestions have not yet changed the way in which the field is designated , so i retain the term
philosophy of film
throughout this entry .
kupfer , joseph h . , 1999 . visions of virtue in popular film , boulder : westview press .
––– , 2011 . seeing fictions in film : the epistemology of movies , oxford : oxford university press .
geoffrey rush is an australian actor best known for his award - winning performance in the 1996 film shine .
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but moviegoers took little notice of those who attacked the film . they flocked to the cinemas , dirty harry ' s dialogue passed into common parlance , and it now occupies an important if uneasy place in film history .
the second peculiarity is that within film studies—itself an institutionalized area of academic study—there is a sub - field of film theory that has significant overlap with the philosophy of film even though the majority of its practitioners operate on significantly different philosophical assumptions than anglo - american philosophers of film . in the balance of this entry , i shall include both of these areas under the rubric of the philosophy of film , although my primary emphasis is on the contributions of anglo - american theorists and i will occasionally distinguish this field from film theory as practiced within the area of film studies . one of the characteristics of philosophy as a discipline is its questioning of its own nature and basis . the philosophy of film shares this characteristic with the field in general . indeed , a first issue that the philosophy of film must address is the grounds for its own existence . this involves not only the question of what the field should look like , but also that of whether it has any reason to exist at all .
singer , irving , 2010 . cinematic mythmaking : philosophy in film , cambridge , ma : the mit press .
in a meeting with mayor rahm emanuel , lee recalls ,
the mayor objected that the title was going to give chicago a bad image , that it would hurt tourism , that it would hurt economic development on the south side . but let ' s be clear : he never said to me , ' spike , don ' t make this film . ' what he said was : ' spike , i like your films . i just don ' t like the title of this one . '
was titled “do the race thing : spike lee’s afro - fascist chic , ” and accused lee of immaturity and propagandizing for black nationalism . in fact , lee is as hard on the film’s black characters for their political apathy as he is on the pizzeria owner , sal , who is scarcely a one - dimensional race baiter ; “do the right thing” is inarguably among the most thoughtful and unsentimental meditations on race relations committed to film . scorsese calls it “a wonderful film , a tough picture that puts it right out there . ” the
the discussion of the realist character of film continues to be a topic of heated debate among philosophers of film . most recently , the emergence of digital technologies for fashioning the image raise very basic questions about the plausibility of this view .
after all , as long ago as 2008 , her video for girlfriend became one of the first on youtube to bust through the 100m views mark . this traffic , though , was itself allegedly driven mainly from a dodgy source – one fansite that encouraged users to follow a link which would keep the video open in their browsers , then refresh it every 15 seconds to spike the view - counter . the malware motherlode normally comes through similar shady sub - scripts – the saga continues .
the trailer does nothing for this film . in fact , when i viewed it , i felt the movie looked cheap , silly , and somewhat amateurish . so when i sat down to watch “spike” , i was dreading it . i just plain did not want to watch the film . thankfully , i was wrong and the film is actually really good . that isn’t to say this is my type of film , which it isn’t , but this one could very well find an audience and become a cult classic . four friends are on a road trip in the middle of the night when their tire pops and the driver loses control , skidding to a stop in the woods .
it might therefore seem surprising that there is a significant tendency among film scholars to treat films as the product of a single individual , its auteur or author . on this line of interpretation , the director of the film is the creative intelligence who shapes the entire film in a manner parallel to how we think of , say , literary works being authored .
but once the philosophy of film is granted autonomy as a separate sub - field of aesthetics , the question arises as to its form . that is , philosophers are concerned with the issue of how the philosophy of film should be constituted as a field of study . what role is there for film interpretation in the field ? how do studies of particular films relate to more theoretical studies of the medium as such ? and what about philosophy in film , a popular mode of philosophic thinking about film ? is there a unified model that can be employed to characterize this newly vitalized domain of philosophic inquiry ?
but even though the film didn’t knock my proverbial socks off in a horror - related way , it’s actually not bad . . . as long as you’re not expecting to be scared . spike is a thoughtful , well - acted reprisal of the beauty and the beast legend , but with a modern and weird twist to it .
lee pace and catinca untaru in one of the swashbuckling scenes in the fall ,  a film with two parallel stories .
freeland , cynthia a . , and thomas e . wartenberg , 1995 . philosophy and film , new york : routledge .
krakauer , siegfried , 1960 . theory of film : the redemption of physical reality , new york : oxford university press .
litch , mary , and amy d . karofsky , philosophy through film , 3rd edition , abingdon , uk : routledge .
livingston , paisley , 2009 . cinema , philosophy , bergman : on film as philosophy , oxford : oxford university press .
ufc primetime : georges st . pierre vs bj penn ( spike ) television series that followed bj penn and georges st . pierre as they trained for their fight against each other . jan 2009 on big island .
mallett and henderson are represented by paul bresnick literary agency , llc , new york , and for film by united talent agency .
allen , richard , and murray smith ( eds . ) , 1997 . film theory and philosophy , oxford : clarendon press .
carel , havi , and greg tuck , 2011 . new takes in film - philosophy , basingstoke , uk : palgrave macmillan .
currie , gregory , 1995 . image and mind : film , philosophy , and cognitive science , cambridge : cambridge university press .
“we started implementing a corrective action plan in september that will ensure more accurate reporting of the growing and diverse film industry in our state , ” says illinois film office spokeswoman jacquelyn reineke . “the diversity standard we employ sets illinois’ film program apart from the rest of the country , and we continue to look for new ways to reach out and utilize the talents of minority vendors . ”
illinois has doled out more than $ 330 million in tax credits to 1 , 410 productions that spent more than $ 1 . 1 billion in the state since 2008 , state records show . the largest credit — $ 11 . 5 million — went to the company that produced the sci - fi film “divergent . ” the smallest — $ 4 , 817 — went to northfield’s towers productions for a tv pilot called “earth uncensored . ”
spike lee will co - write and direct
time traveler ,
a feature adaptation of a memoir by ronald mallett , one of the nation ' s first african - americans to earn a ph . d in theoretical physics .
you specifically wanted the film to hurt koch , right ? we have one scene where our man spray - painted dump koch . and also we had this plan because the film came out in august and that fall was the democratic primary . so throughout the film , you hear mister señor love daddy , played by samuel jackson , telling people to vote , vote , vote . and dinkins won .
just a small sampling of his other film and tv credits include copland , nypd blue , law & order , this thing of ours and spy . his imdb page lists an upcoming 2018 film , asbury park , which also includes his old pal and costar pesci .
bordwell , david , and nöell carroll . 1996 . post - theory : reconstructing film studies , madison : university of wisconsin press .
the film will screen in cinemas for one week only from thursday may 11 . the list of participating cinemas can be found at urltoken
i have one main gripe about this film . i hate to do it but i have to admit that the dialogue annoyed me , at times . that is a personal gripe though and there is a line in the film where the girl tells spike that what he said was the cheesiest line ever heard . this tells me that writer / director robert beaucage was well aware of the territory he was delving into and poked a little fun at it . and to the casts credit , really sell the story and the dialogue works . the story revolves around spike and the methods he chooses to try and win the love of the girl . edward and sarah have a chemistry that comes across on - screen and are gifted performers .
spike lee ' s take on the
son of sam
murders in new york city during the summer of 1977 centering on the residents of an italian - american northeast bronx neighborhood who live in fear and distrust of one another .
festive children ' s animation following the adventures of a young elf who graduates to santa ' s workshop . unfortunately , as hard as spike tries , he struggles to adapt to life in the workshop . . . see full summary »
- every conceivable method is used to minimize and postpone expenditures . digital makes both easier . it reduces the cost of production by eliminating the cost of film stock and processing , and camera rental . digital also postpones , and in some cases eliminates , the cost of making film prints if filmmakers use digital projection at festivals . they often decide not to make a film print if theatrical distribution isn’t an option .
“she’s gotta have it” premièred at the san francisco film festival and prompted a bidding war for the distribution rights . it opened in the summer of 1986 , with what lee calls a “marketing gimmick” : for nearly a month , the movie could be seen at only one theatre in america , cinema studio , at sixty - sixth and broadway . “every night it was sold out , ” lee recalled . “and i would get there and hand out buttons . me and my friends were selling ‘she’s gotta have it’ t - shirts . ” when the film opened in wide release , it made about seven million dollars . the credits announced the film as “a spike lee joint . ” lee told me , “from very early on—not that i was that sophisticated , but , coming from the independent world , i knew that millions and millions of dollars were not going to be spent on the promotion and marketing of my film . so in a lot of ways i had to market myself and market the brand of spike lee . ”
lee is still angry about the accusations . “they’re , like , ‘so , spike , are you saying that every single jewish person is a crook ? ’ ” he told me . “get the fuck out of here ! that’s crazy . ”
jodie foster and samuel l . jackson are honorary co - chairs . spike lee gives the keynote address . john turturro hosts the show . a new filmmaker grant for emerging producers is added with a cash prize of $ 20 , 000 .
everal people have surprised me by saying that one of the movie’s biggest legacies is the impact you had on diversifying new york film crews .
' favorite scene in the original book , is when max meets a sea monster . that scene is however not included in the film .
in opposition to such a negative view of film ' s relationship to society , philosophers of film have argued that popular films need not support social domination but can even give expression to socially critical attitudes . in making this argument , they have corrected film theory ' s tendency to make broad generalizations about the relationship between film and society that are not grounded in careful analysis of individual films . they have instead concentrated upon presenting detailed interpretations of films that show how their narratives present critical takes on various social practices and institutions . class , race , gender , and sexuality are among the different social arenas in which philosophers of film have seen films make socially conscious , critical interventions in public debates .
smith , murray , and thomas e . wartenberg , 2006 . thinking through cinema : film as philosophy , malden , ma : blackwell .
thomson - jones , kathryn ( ed . ) , 2016 , forthcoming . current controversies in philosophy of film , new york : routledge .
––– , 1997 . “ le grand imagier steps out : the primitive basis of film narration , ” philosophical topics , 25 : 295–318 .
philosophers of film have generally opposed this view , seeing film as a source of knowledge and , even , as potential contributor to philosophy itself . this view was forcefully articulated by stanley cavell , whose interest in the philosophy of film helped spark the field ' s development . for cavell , philosophy is inherently concerned with skepticism and the different ways that it can be overcome . in his many books and articles , cavell has argued that film shares this concern with philosophy and can even provide philosophic insights of its own ( cavell 1981 ; 1996 ; 2004 ) .
copy : content and programming copyright 2008 fox news network , llc . all rights reserved . transcription copyright 2008 voxant , inc . ( urltoken ) , which takes sole responsibility for the accuracy of the transcription . all rights reserved . no license is granted to the user of this material except for the user ' s personal or internal use and , in such case , only one copy may be printed , nor shall user use any material for commercial purposes or in any fashion that may infringe upon fox news network , llc ' s and voxant , inc . ' s copyrights or other proprietary rights or interests in the material . this is not a legal transcript for purposes of litigation .
carroll , nöel and jinhee choi , 2005 . the philosophy of film and motion pictures : an anthology , malden , ma : blackwell publishers .
chatman , seymour , 1990 . coming to terms : the rhetoric of narrative in fiction and film , ithaca , ny : cornell university press .
but the agency that runs the illinois film office routinely has violated that part of the law , a chicago sun - times investigation has found .
oh , padding . the scene takes place in the film’s first few minutes , so it actually does serve a purpose , as it helps prepare us for all of the similarly useless padding to follow . spike “tortures” the guy three times throughout the course of the film , and we also have scene after scene of spike telling the girl how much he has missed her and how much he wants to be with her . we got it , buddy - move on . there is also a subplot about the other two ( the lesbians ) arguing over whether or not to try to find the others or look for a call box . these scenes are so similar they might as well have just filmed one such version and re - used it whenever they felt the need to cut to this drivel .
1 . george lucas and friends at the spike tv scream 2008 awards . 2 . christopher nolan accepts one of the 12 trophies for “the dark knight . ” 3 . marilyn manson owns a lot of black clothes . 4 . tim burton makes his way to the stage beneath ballons . 5 . frank miller is flanked by two of the actresses from “the spirit , ” paz vega on the left and jaime king on the right . 6 . wes craven was given a career excellence award . 7 . kerli performed , as did the smashing pumpkins . 8 . anothony hopkins was honored with a legend award .
the n . y . u . film program is one of the best in the country . ( the director ang lee was in lee’s class , jim jarmusch was there at the same time , and joel coen had graduated from the undergraduate film program a year earlier . ) during his first year at n . y . u . , lee was shown a number of classic movies by his professors , including the 1915 film “the birth of a nation , ” by d . w . griffith , who pioneered many cinematic techniques still in use today . but the film was notorious , even at the time of its release , for its endorsement of white supremacy and its glorification of the ku klux klan . ( griffith adapted the film from a
a stand - up comic at the time , martin lawrence made his feature film debut in the supporting role of cee , a local neighborhood teen .
cavell , stanley . 1979 . the world viewed : reflections on the ontology of film , enlarged edition , cambridge , ma : harvard university press .
cox , damian , and michael levine , 2011 . thinking through film : doing philosophy , watching movies , chichester , uk : wiley - blackwell .
read , rupert , and jerry goodenough , 2005 . film as philosophy : essays on cinema after wittgenstein and cavell , london : palgrave - macmillan .
––– , 2001 . “film , ” the routledge companion to aesthetics , berys gaut and dominic mciver lopes ( eds . ) , london : routledge .
wartenberg , thomas e . and angela curran , 2005 . the philosphy of film : introductory text and readings , malden , ma : blackwell publishers .
21 . miracle at st . anna ( 2008 ) : turns out that lee’s feud with clint eastwood over flags of our fathers ’ lack of black characters was a lot more memorable than the movie he made as a response to hollywood’s history of minimizing african - americans’ battlefield contributions . this 2008 commercial bomb fascinates because it shows the veteran filmmaker still pushing himself as he attempts a grand - canvas world war ii epic with some grippingly tense battle scenes . but as with so many of his ambitious misfires , miracle at st . anna works mostly as an intriguing experiment , saddled with a dull , sentimental narrative that traffics in the kind of war - movie clichés you’d assume lee would be too smart to repeat .
a related issue concerning narrative that has been a focus of debate is whether all films have narrators , including those without explicit ones . initially , it was argued that the idea of a narratorless narrative did not make sense , that narration required an agent doing the narrating , who was the film ' s narrator . in cases where there were no explicit narrators , an implicit narrator needed to be posited to make sense of how viewers gained access to the fictional world of the film . opponents responded that the narrator in the sense of the agent who gave film audiences access to a film ' s fictional world could be the filmmaker ( s ) , so there was no need to posit such a dubious entity as an implicit narrator of a film .
“spike” may not be for everyone . there isn’t much for the gore fiends and it is a story about finding and holding on to the one you love , in a very different and bizarre way , but love none the less . it is an interesting take on the “beauty and the beast” formula with a darker twist and much more of a tragic story . and that is why it worked for me . i hate romance films but love tragic ones . maybe that makes me a bit twisted , but if i wasn’t i probably wouldn’t be writing these reviews . robert beaucage is gonna be a talent to watch and “spike” is definitely a film deserving of a cult following .
on january 22 , 2008 , ledger was found unconscious in his bed by his housekeeper , teresa solomon , and his masseuse , diana wolozin , at his apartment in the soho neighborhood of manhattan . according to police reports , wolozin used ledger & apos ; s cell phone to call ledger & apos ; s friend , mary - kate olsen , for help .
as part of their argument , these film theorists have gone beyond examining individual films themselves and have argued that the very structure of the narrative film functions to assist in the maintenance of social domination . from this point of view , an overcoming of narrativity itself is required for films to be genuinely progressive .
associate professor of cinema studies and africana studies at new york university , ed guerrero ' s popular books do the right thing ( british film institute , part of the bfi ' s modern classics series ) and framing blackness ( temple university press ) explore black cinema ' s cultural , political and aesthetic history , as well as its critical discourse . here he discusses the rich legacy of spike lee ' s work .
the idea that the philosophy of film should model itself upon a scientific model has been contested from a variety of points of view . some philosophers , relying on the writings of pragmatists like william james , have questioned the idea that natural science provides a useful way to think about what philosophers are doing in their reflections on film . here , there is an emphasis on the particularity of films as works of art in contrast the to the urge to move to a general theory of film . others , making use of later wittgenstein as well as the tradition of hermeneutics , also question such a natural scientific orientation for philosophic reflections on film . this camp sees the study of film as a humanistic discipline that is misunderstood when it is assimilated to a natural science .
by prolific filmmaking ; creating a celebrity / actor persona ; applying a new business model ; and perhaps most importantly , focusing on survivability and success as a
final cut
director in mainstream commercial cinema , spike lee made a huge contribution to jump starting a whole new outlook on black filmmaking . by persisting in his vision , as he says to
make one film after another
for the mainstream industry and theatres , lee is one of a handful of directors to survive the ' new black film wave ' on his own commercial and creative terms . by industry standards , lee has kept busy making at least one commercial feature film a year , and this interspaced with a steady flow of other media and commercial projects .
, because if you took out every line of dialogue in the film and replaced it with something that sounded human , it might be an ok movie .
the ballad of narayama
is a japanese film of great beauty and elegant artifice , telling a story of startling cruelty . what a space it opens…
faison reached new career heights after the film ' s release , with memorable turns in blockbusters like 1991 ' s
the silence of the lambs .
a film about a group of conquistadors who come across a group of aztec villagers that worship two tyrannosaurus rexes . starring ian ziering . 2007 on oahu .
family including ledger’s sister kate also speak in the film , but a press release today stated the family would not be conducting any interviews around its release .
ross douthat joined the new york times as an op - ed columnist in april 2009 . previously , he was a senior editor at the atlantic and a blogger for urltoken . he is the author of
privilege : harvard and the education of the ruling class
( hyperion , 2005 ) and the co - author , with reihan salam , of
grand new party : how republicans can win the working class and save the american dream
( doubleday , 2008 ) . he is the film critic for national review .
this list originally ran in august 2012 , tied to the release of spike lee ' s red hook summer . in the three years since , lee has released a 2013 remake of oldboy , last year ' s da sweet blood of jesus , and , as of this week , the powerful mess of a film chi - raq . we ' ve updated this list to include those recent offerings from this true hollywood original .
in his pathbreaking study of what he called “classical film theory , ” noël carroll ( 1988 ) argued that there were many illicit presuppositions at play in the classical theorists ' attempts to define film ' s nature . in particular , he accused them of confusing particular styles of filmmaking with more abstract claims about the nature of the medium itself . his accusations seemed to spell the end of such attempts to justify film styles by their grounding in the medium ' s nature .
lee has continued to explore racial themes in his works , as is the case with 1992 ' s
malcolm x
and 2000 ' s
bamboozled .
other credits include 1998 ' s
he got game ,
1999 ' s
summer of sam ,
2002 ' s
25th hour ,
2006 ' s
inside man
and 2008 ' s
miracle at st . anna .
lee ' s latest film ,
da sweet blood of jesus ,
was financed primarily through kickstarter donations .
9 . she ' s gotta have it ( 1986 ) : famously shot in two weeks on a nonexistent budget , lee’s first film is completely all over the place , part in - your - face polemic , part buppie–woody allen–esque social comedy . like its main character — spike’s mars blackmon , soon to be immortalized in michael jordan commercials — it’s obnoxious , loud , incorrigible , and completely ingratiating , in spite of its self .
in addition to acting in the film ( in which she had to perform topless in one of her scenes ) , perez also served as the official choreographer .
and then is television . although many film scholars and philosophers of film has a disparaging view of television , the emergence of such shows as the sopranos and the wire established television as a medium for making valuable works of art . as a result , it makes sense to include such shows under the rubric of films .
as film and its related digital media continue to expand in their influence upon the lives of human beings , the philosophy of film can be expected to become an even more vital area for philosophic investigation . in the coming years , we can look forward to new and innovative contributions to this exciting area of philosophical research .
hannity : next question about spike lee and his race obsession . he said about — after hurricane katrina and the catastrophe , he said ,
it ' s not too far - fetched , i don ' t think , to put past anything the united states government .
heath ledger was born on april 4 , 1979 , in perth , australia . his breakout role was in the film 10 things i hate about you with julia stiles . ledger received academy award and golden globe nominations for his role in brokeback mountain . in 2008 , after completing filming on christopher nolan & apos ; s the dark knight , ledger died as the result of an accidental prescription drug overdose . he received a posthumous best actor academy award for his performance as
the joker .
ledger had a daughter with actress michelle williams .
ledger had told the new york times in november of 2007 that he was taking ambien , a prescription medication used for the short - term treatment of insomnia . he discussed the difficulty that he was having with portraying the joker in batman sequel the dark knight ( 2008 ) , a character he described as a
psychopathic , mass - murdering , schizophrenic clown with zero empathy .