blood car is a 2007 black comedy film set in the not-too-distant future where gasoline prices have become exorbitant ( $ 30 + us/gallon ) .

things take a turn for the worse when a kindergarten teacher ( mike brune ) invents a car that runs on a different fuel source : blood .

blood car

at just 75 minutes , even a car on blood still runs out of gas .
a schoolteacher struggles to fuel his latest invention : a car that runs on blood .
in the future gas prices are $ 30 a gallon and one man invents a car that runs on human blood .
the aptly - named blood car is a near - future tale about peak oil and bloodthirsty vegans . gasoline is …
' blood car ' is essentially a one - joke scenario that never quite adds up to the sum of its mangled body parts .
we measured the number of car - bcma + cells in the blood of all patients with a qpcr assay that was able to specifically detect car - bcma + pbmcs ( figure 4a ) . although car - bcma + cells could be detected in the blood of all patients , the patients on the lower 2 dose levels had low levels of blood car - bcma + cells , and the patients with the most impressive antimyeloma responses , patients 8 , 10 , and 11 , had the highest peak car - bcma + cell levels . by 3 months after infusion , blood car - bcma + cell levels had decreased to 0 . 1 % of pbmcs or less in all patients .
blood car may have been collecting prizes and earning praise for its supposedly wickedly twisted satire but it still seems trashy , b - movie junk .
the award winning debut feature from director alex orr , the pitch - black comedy blood car mixes surrealist humour , sharp social commentary , kinky sex and buckets of blood . starring anna chlumsky ( best known for her charming starring role in my girl two decades ago ) , mike brune and katie rowlett , blood car is an independent horror - comedy gem that fully deserves to be rewarded with the cult status . blood car ( cert . 18 ) is released by left films and will open at selected cinemas around the uk from 24th february 2012 .
blood car director : alex orr genre : dark comedy dvd street date : march 3 , 2015 dvd srp : $ 19 . 95 dvd upc : 738329162429
autologous peripheral blood mononuclear cells ( pbmcs ) were cultured with an anti - cd3 monoclonal antibody to induce t - cell proliferation . the cells were transduced with the γ - retroviral vector that encoded that car , and 9 days after the initiation of cultures , car - bcma t cells were infused . details of the car t - cell production are in supplemental methods , available on the blood web site .
in the not so distant future , gas prices have skyrocketed to a crushing 30 bones a gallon . the prices forces one good - natured vegan to get creative and find alternate means of fuel but instead of building a car that runs on veggies , he accidentally invents a car that runs on blood . now that ' s the kind of gory thinking they should have used in the death race remake : more blood , less common sense . click through for the full blood car poster and trailer .
the effectiveness of anti - cd19 car t cells against b - cell malignancies encouraged us to develop a car t - cell therapy for multiple myeloma .
publisher ' s note : there is an inside blood commentary on this article in this issue .
message body ( your name ) thought you would be interested in this article in blood journal .
vegan schoolteacher archie is trying to invent an alternative engine that runs on wheatgrass , but when he accidentally cut himself he discovers that all his engine needs to work is blood… human blood . with his blood - fuelled car , archie soon draws the attention of sex - crazed hottie denise , who will do anything for a ride . but government agents are spying on archie , as he is forced into ever more shocking and extreme behaviour to keep his blood car on the road , in this award - winning critically - acclaimed black comedy .
we had a great turn out for our second to last set of feature films for the festival blood car and disarm . both jack hammond of disarm and alex orr of blood car where on hand for the screening and answered audience questions . both movies were very appreciated by the audience and we hope to see both directors again in future festivals .
horizon movies is pleased to announce the dvd release of the cult festival hit blood car , a black comedy — directed by alex orr and starring mike brune , katie rowlett and anna chlumsky — set in a not - too - distant future in which the exorbitant cost of fuel drives one enterprising man to create a car engine that can run on human blood . combining elements of social satire and horror , sight and sound called blood car “a mordant , raunchy and at times gory trip into the dark heart of the american dream” .
see more matte vinyl car wrap silk brown 50ft x 5ft com . . .
with the headline : film ; the brothers coen bow in with ' ' blood simple ' ' .
the vast majority of cases of kidney failure are caused by complications of diabetes or high blood pressure .
in the near future , gas prices are at an astronomical high . one man is determined to find an alternate fuel source . that alternate fuel source turns out to be blood . . . human blood .
matte vinyl car wrap silk brown 50ft x 5ft comes with . . .
veering between wicked social satire and outbursts of hardcore gore , blood car lives up to its reputation as an “audacious , utterly bonkers and downright sick claret - drenched black comedy” ( time out london ) .
26 . 2 marathon runner vinyl decal sticker car window wall bumper running man 13 . 1
in the very near future , no - one can afford to drive any more . fuel prices are at an astronomical high and car parks have become graveyards for abandoned cars . vegan school teacher archie is trying to invent an alternative engine that runs on wheatgrass , but when he accidentally cuts himself he discovers that all his engine needs to work is blood . . . human blood . with his blood - fuelled car , archie soon draws the attention of sex - crazed hottie denise , who will do anything for a ride . but the authorities are already following archie , as he is forced into ever more shocking and extreme behaviour to keep his blood car on the road , in this award - winning critically - acclaimed black comedy .
novartis : car - t results in one month , or no charge . why one month ?
car - bcma t cells became more differentiated after infusion . for a - l , cells from patient 10 are shown . all plots are gated on live lymphocytes , and the numbers on the plots are the percentages of cells in the indicated regions of the plots . staining for car - bcma was performed with pe - bcma - fc . all postinfusion samples were pbmcs that were collected 16 days after car - bcma t - cell infusion . ( a ) cells from the time of infusion ( infusion cells ) were stained for cd3 and car - bcma . ( b ) this plot is gated on the cd3 + car + infusion cells . ( c ) postinfusion cells were stained for cd3 and car - bcma . ( d ) this plot is gated on postinfusion cd3 + car + cells . car t cells after infusion were predominantly cd8 + . ( e ) ccr7 and cd45ra expression of cd3 + cd4 + car + infusion cells is shown . ( f ) ccr7 and cd45ra expression of cd3 + cd8 + car + infusion cells is shown . ( g ) ccr7 and cd45ra expression of postinfusion blood cd3 + cd4 + car + t cells . ( h ) ccr7 and cd45ra expression of postinfusion blood cd3 + cd8 + car + t cells . ( i ) cd3 + cd8 + car + infusion cell pd - 1 and cd28 expression are shown . ( j ) pd - 1 and cd28 expression is shown on postinfusion blood cd3 + cd8 + car + t cells . ( k ) cd57 and cd28 expression on cd3 + cd8 + car + infusion cells is shown . ( l ) cd57 and cd28 expression of postinfusion blood cd3 + cd8 + car + t cells is shown . for m - p , results are shown for all 4 patients with sufficient blood car - bcma + t cells from 7 to 16 days after infusion for analysis . gating and analysis were performed as described above in a - l . the results are all for live cd3 + car + cells . the symbols shown in m correspond to the same patients for m - p . ( m ) the cd8 + to cd4 + ratio of car - bcma t cells increased for all 4 assessable patients between infusion and the time the postinfusion samples were collected . the percentage of cd8 + car - bcma t cells with ( n ) em or emra phenotypes , ( o ) pd - 1 expression , and ( p ) cd57 expression increased in all 4 assessable patients between infusion and the time a postinfusion sample was collected .
car - bcma t cells can eliminate mm cells even when high concentrations of soluble bcma are present in the blood of patients ( figure 4d ) . in addition to being an important finding for car - bcma t - cell therapy , this finding is important because many other promising car target antigens are also present in soluble form in blood and at tumor sites . 45 , 46 serum bcma served as a tumor marker because substantial decreases in serum bcma occurred in the 3 patients with the most impressive antimyeloma responses ( figure 4d ) .
the city alleged contributory negligence based largely on the result on a standard test for blood alcohol . using a blood sample drawn from krall less than an hour after the collision , the test revealed a blood alcohol level of 0 . 159 . the illinois legal limit is . 10 , said defense counsel gregory e . rogus of chicago ' s segal mccambridge singer & mahoney .
when archie and denise are in the car in the beginning of the movie , the car runs out of gas , from a few seconds earlier until that moment you can clearly see outside there is woods , but in the next shot denise get out of the car right in front of a house .
efficacy and toxicity management of 19 - 28z car t cell therapy in b cell acute lymphoblastic leukemia .
the year is the future . you have a car and run people over but it ' s ok because they ' re like zombies or something . evil zombies . evil zombies created in a government - run conspiracy . and only one person can stop them . that person is you . . . and your car . in the end there ' s a plot twist like where you were the zombie all along and stuff but you don ' t know that yet . oh yeah your car is called the blood car ! 2000 !
these results demonstrate for the first time that car t - cells targeting an antigen other than cd19 can induce complete remissions of a hematologic malignancy . importantly , we have shown that car - bcma t cells have powerful activity against mm that was resistant to standard therapies . these results should encourage further efforts to enhance anti - bcma car t cell therapies . the striking activity of anti - bcma car t cells against mm indicates that car t cells targeting bcma have great potential to be an effective new treatment of mm . further development of anti - bcma car t - cell therapies is a very promising area of research .
blood car by alex orr could be termed the anti - grindhouse . it hit all its notes perfectly , nailing and sending up the exploitation genre , with a dose of environmental topicality . in the film ' s wildly inventive plot , an everyman who is tired of rising gas prices and the obscene profits of the oil conglomerates , decides to take matters into his own hands . . . . by building a blood car , a car that runs on blood ( clearly more available than oil ) . in this campy instant cult film , orr mixes buckets - of - blood horror with social commentary and even a little sex for good measure . when our hero falls for the girl of his dreams , he must make a critical decision about how much bloodletting he will do in order to keep his automobile in good running order .
patients with the most impressive antimyeloma responses had the highest levels of blood car - bcma + cells . ( a ) car - bcma + pbmcs were quantified in the blood of patients by qpcr . patients treated on the 2 lower dose levels had low levels of car - bcma + cells in their blood ( left ) . patients treated on the higher 2 dose levels had higher levels of car - bcma + cells in their blood ( right ) . patients 8 , 10 , and 11 had the best antimyeloma responses and the highest levels of blood car - bcma + cells . the results are presented as the absolute number of car + pbmc / μl of blood . pre stands for pretreatment . ( b ) il - 6 was measured in the serum of all patients . patients 10 and 11 ( right ) had the most severe cytokine - release syndrome , and these patients also had the highest serum il - 6 levels . serum il - 6 levels of the other patients are shown on the left . note the different y - axis scales on the left and right graphs . ( c ) five days after car - bcma t cell infusion , serum levels of 15 cytokines were measured in the blood of patient 10 and patient 11 . results are expressed as fold increase over pretreatment levels . ( d ) serum soluble bcma of all patients was measured by elisa pretreatment and posttreatment . the posttreatment serum samples were obtained 22 to 29 days after car t - cell infusion for all patients except patient 12 . the posttreatment sample of patient 12 was obtained 13 days after car t - cell infusion . all patients had detectable serum bcma . in the patients obtaining the most impressive antimyeloma responses , patients 8 , 10 , and 11 , serum bcma decreased posttreatment ( right ) ; in contrast , serum bcma did not decrease substantially posttreatment in the other patients ( left ) .
steven grillo and friends at the
harry potter and the half - blood prince
movie premiere on long island , new york .
and now we have conducted the first - in - humans clinical trial of anti–bcma - car t cells .
lineage switch as a relapse mechanism of pre - b acute lymphoblastic leukemia following cd19 car [ abstract ] .
krall v . city of des plaines - left - turning driver involved in crash with des plaines patrol car .
“it’s the future – like , two weeks from now , ” deadpans a suited government agent direct to camera in blood car ’s opening scene , eating crisps like a cinemagoer as he introduces “a story about a man… about his invention… about society… about you . ”
in a dystopian alternate 1999 , a former cop is forced to take part in a death race in which cars run on human blood as fuel .
paige mcatee at a grocery store at midnight to get
harry potter and the half - blood prince
book on long island , new york .
this rumor claims that a university student in india died from too much co2 in his blood after drinking eight bottles of coca - cola too quickly .
i could probably sum up my entire review of this game by simply referring to it as
like the classic kill car , but actually fun to play .
you basically drive around and run people down , but this game loses the crappy rpg elements of kill car in exchange for blood particle physics and blood decals on the car that make it look like you ' ve just strapped nails to your tires and driven through a playground full of ketchup - filled balloons . you would think that ' s all this game would need , but i wouldn ' t be wording it this way if the rest of the review was all sunshine and butt kissing .
car - expressing t cells targeting the b - cell antigen cd19 can induce lasting complete remissions of b - cell malignancies .
alex orr ' s dark comedy blood car stars mike brune as archie andrews , a mild - mannered elementary teacher attempting to beat the high cost of gasoline ( forty bucks a gallon ) by creating a car that runs on something other than traditional petrol . he makes large purchases of wheatgrass from a young store clerk ( anna chlumsky ) who has a crush on the teacher . however , when he discovers that his new invention runs best on human blood , archie suddenly becomes involved with a woman who does not share his or the store - clerks environmental beliefs . ~ perry seibert , rovi
you might think strange title ? put it in the dvd player , whowwww your in for a treat . very funny titles ie watch this - - - t more of this s - - t , so you know your in for a good time . we have watch it 3 times friends have done the same . the film is about petrol been about $ 15 a gallon , so if you got a car you are quids in with any hot chicks out there . nobody has cars due to this reason . so in comes along a teacher who by mistake invents a fuel to run on blood . so any thing with blood in goes in the boot gets liquidises up and runs the car for a short time . he has a fixation with a girl who loves his car but not him . great one liners , lots blood . serious cult flim . watch twin town aswell .
a naked , blood - soaked man throws a corpse into a dimly lit basement . the cadaver lands against another body . ( source : imdb ) read more »
seattle children’s is now aiming for car - t therapy not for the most desperate cases , but to treat , even cure , kids earlier in the course of the disease . the decision has also left novartis , which is charging $ 475 , 000 per treatment , with no competition for the time being . cripe , chief of the blood cancer and bone marrow transplant division of nationwide children’s hospital in columbus , oh , sees other programs eventually giving doctors more options , especially more cost - effective “off the shelf” car - t therapies that use donor blood cells instead of a patient’s own cells .
toxicities that are mainly caused by cytokines ( cytokine - release syndrome [ crs ] ) also occur after car t - cell infusions .
we chose to focus on improving anti - bcma car t - cell therapies by simultaneously pursuing several different projects . we believe that optimizing car design is currently the most important way to improve car t - cell therapies ; therefore , we are pursuing different projects aimed at finding the optimal design for anti - bcma cars . we are collaborating on a clinical trial of a 4 - 1bb–containing anti - bcma car . for the trial using the cd28 - containing car that is the subject of this report , we decided to administer different doses based on disease burden . because of the toxicities experienced by patients 10 and 11 , we will only administer 9 × 10 6 car - bcma t cells / kg to patients with < 50 % bone marrow plasma cells ; patients with > 50 % bone marrow plasma cells will receive 3 × 10 6 car - bcma t cell / kg . we are also undertaking a preclinical project that will examine the hinge and transmembrane regions of anti - bcma cars , and we are attempting to develop a fully human anti - bcma car .
although the response rates for anti - bcma car t cells against mm reported here are not as high as previous reports of anti - cd19 car t cells against b - cell malignancies , 16 , 17 , 19 , 25 the number of patients treated with anti - bcma cars is quite small . compared with the doses of anti - cd19 car t cells generally required for efficacy and toxicity in our experience ( 1 - 2 × 10 6 / kg ) , 19 higher doses of anti - bcma car t cells ( 3 - 9 × 10 6 car + t cells / kg ) were required to elicit substantial antimalignancy responses and toxicity . this difference could be due to many factors including weaker bcma expression on malignant cells in comparison with cd19 , differences in car design between anti - cd19 cars used previously and the anti - bcma car used in this work , and the presence of soluble bcma in serum and at tumor sites .
the anti - bcma car used in this work ( car - bcma ) incorporated the 11d - 5 - 3 anti - bcma single - chain variable fragment ( scfv ) , a cd28 costimulatory domain , and the cd3−ζ t - cell activation domain ( figure 1a ) . 12 the car sequence was expressed by a γ - retroviral vector backbone used in previous work . 11 , 14 car - bcma was consistently expressed on the surface of transduced cd4 and cd8 t cells , and the transduced t cells proliferated extensively in culture ( figure 1b - c ; supplemental tables 1 and 2 ) . a median of 67 . 0 % ( range , 45 . 3 - 90 . 8 % ) of infusion t cells expressed car - bcma . car - bcma t cells specifically recognized bcma in vitro ( figure 1d ) .
early - phase clinical trials have shown high rates of complete remission ( cr ) after cd19 car - t - cell therapy , even in patients who have failed multiple chemotherapy regimens and / or allogeneic hematopoietic stem cell transplantation ( hct ) . durable remissions can be achieved when functional car - t cells persist sufficiently long to eradicate all malignant cells in the recipient ; however , leukemic relapse may occur with premature loss of cd19 car - t cells or because of the emergence of leukemia that has lost cd19 expression despite persistence of functional cd19 car - t cells .
cd19 - targeted car - t - cell therapy of patients with mll - rearranged b - all effectively induced marrow remission of b - all .
upon its completion , blood car was given a quick and limited dvd release in the u . s . , even as it continued to win acclaim on the international festival circuit . largely overlooked in the states , it was embraced by uk critics as “a slacker take on roger corman movies like the little shop of horrors or death race 2000” ( empire ) . now , seven years later , horizon movies and kino lorber re - introduce blood car to the american viewer in a special new edition , so that this loony yet scathing satire of a gas - guzzling nation on the verge of social collapse can finally gain the domestic notoriety it deserves .
anyone who is interested in detailing a car , cares about their car . who in their right mind would ever think of installing any material that is not built for automotive application ! ? . there is a disconnect with info between what you can use and what you can ' t .
two teddy - bears go hunting unicorns , their favourite prey . unicorns have tender flesh and delicious blueberry - flavoured blood which the bears need to stay cute - looking . read more »
we ' ve shown you footage from blood car before and i ' ve gotta say this looks like a great c - film . especially since it brings my girl ' s anna chlumsky ' s into horror . the flick has been popping up in film festivals across the us , but no wide release date has been announced yet .
both chemotherapy agents were administered daily on days −5 , −4 , and −3 before car - bcma t - cell infusion on day 0 . a single dose of car - bcma t cells was administered to each patient . the dose escalation plan called for an initial dose of 0 . 3 × 10
a schoolteacher struggles to fuel his latest invention : a car that runs on blood . after exorbitant gas prices force average americans to seek alternative fuel sources , archie overlooks his vegan beliefs and starts taking desperate measures to help power his new ride . will either of the two women in his life - butcher stand owner denise or veggie stand owner lorraine ( anna chlumsky ) - end up quenching the blood car ' s thirst ? alex orr ' s clever horror comedy is part christine , part little shop of horrors . one thing ' s certain : you ' ll be glad you ' re safe at home . . . contains strong language , sexual scenes , violence and gore .
loss of normal plasma cells after car - bcma t - cell infusions is an expected toxicity because normal plasma cells express bcma . 12 the low polyclonal immunoglobulin levels of patient 11 show that , at least in some cases , immunoglobulin replacement will be indicated in patients receiving anti - bcma car t cells .
a mosquito falls madly in love with a vampire . together they go looking for fresh blood in a baroque , bizarre and dangerous world . . . ( source : lifff ) read more »
appropriate target antigens for car t - cell therapies should be uniformly expressed on the malignancy to be treated and should not be expressed on normal essential cells .
we demonstrated that car - bcma t cells can eliminate large burdens of treatment - resistant mm . the prior treatment histories of patients 10 and 11 demonstrated the chemotherapy resistance of their mm . prior to enrollment on the car - bcma protocol , patient 10 only obtained a pr after 6 cycles of cybord therapy , and he had 90 % bone marrow plasma cells 3 months after high - dose melphalan and asct . high - dose melphalan is a much more effective antimyeloma therapy than the low - dose cyclophosphamide administered immediately prior to car - bcma t - cell infusions . patient 11 had mm that was refractory to cybord therapy . fludarabine , which was administered prior to car - bcma t - cell infusions , has been shown to have essentially no activity against mm . 42 all in all , the antimyeloma responses after car - bcma infusion in patients 10 and 11 cannot be attributed to the chemotherapy administered prior to car - bcma t - cell infusions .
blood car is set to street on dvd march 3 , with a srp of $ 19 . 95 . the disc comes packed with bonus features including two shorts from the fake wood wallpaper film collective , “the adventure” ( 2008 , 21 min . ) and “the $ 100 short short” ( 2006 , 10 min . ) as well as the theatrical trailer .
patients with mll - rearranged b - all who attain cr after cd19 car - t - cell therapy may be at risk for relapse with clonally related aml .
a bodybuilder , extraterrestrials , kidnapping , 40 gallons of blood—this is a beautiful , sometimes silly trip shot in spain in stunning black & white . ( source : new orleans film society ) read more »
for all 12 patients , the median ratio of cd8 + to cd4 + car + t cells in the infusion cells was 1 . 1 ( range , 0 . 3 - 10 . 9 ; supplemental table 4 ) . sufficient car - bcma t cells were available for a phenotypic analysis of blood t cells from 4 patients after infusion ( figure 5 ) . among these 4 patients , the median ratio of cd8 + to cd4 + car + t cells in the infusion cells was 0 . 9 . in contrast , the persisting car + t cells in the blood of the same patients after infusion were mainly cd8 + t cells with a median cd8 + to cd4 + ratio of 28 . 8 ( range , 2 . 5 - 60 . 9 ; figure 5m ) . the expression of c - c chemokine receptor type 7 ( ccr7 ) and cd45ra is used to divide t cells into 4 categories : naïve , central memory ( cm ) , effector memory ( em ) , and effector memory ra ( emra ) . compared with naïve and cm t cells , em and emra t cells are more differentiated with less proliferative potential . 38 ccr7 and cd45ra expression data of the infusion car - bcma t cells of all patients are in supplemental tables 5 and 6 . programmed cell death protein - 1 ( pd - 1 ) is an inhibitory t - cell receptor important in t - cell exhaustion . 39 cd57 is a marker of highly differentiated t cells with reduced proliferative capacity . 40 , 41 in the 4 patients with sufficient car + t cells for phenotypic analysis of blood t cells after infusion , car t cells acquired a more differentiated phenotype with an increase in em and emra t cells after infusion ( figure 5n ) . increases in expression of pd - 1 and cd57 provided further evidence that car - bcma t cells acquired a highly differentiated phenotype after infusion ( figure 5o - p ) .
this is a decent comedy horror that has a unique premise , but could have been done better . the idea of the film is quite good , and the creative aspect is sure to delight horror fans looking for an amusing , mindless film to watch . however , i felt that blood car could have benefitted from a few rewrites as the concept is very good , but it does fall short of what the film could have been . the problem with the film is that it tries to rush things while trying to grab your attention . if this would have been a slightly longer feature , with a bit more depth to its sheer ridiculous plot , then blood car would really have been a great horror comedy . however it does fall short . i ' m not saying it ' s a bad film , but it ' s a film that needed some improvements . despite its imperfections , this is somewhat enjoyable for what it tries to accomplish , and viewers looking for a fun , entertaining low budget b movie , will most likely enjoy this low budget affair . blood car could have been better , but for what it is , it ' s a decent film worth seeing if you love ridiculous horror films . for the most part , blood car works , but there are better b movies out there . i really liked the concept ; i simply wished that the filmmakers would have made the film a bit longer , in order for the story to have a nice flow . as it is , it ' s a rushed film , one that doesn ' t reach its full potential and it ' s a shame because blood car could really have stood out . this is a decent film , but there is nothing remarkable about this b movie , but it ' s worth checking out if you have nothing else better to watch .
a young girl wakes up in the trunk of a car . this is not how she imagined her birthday . . . ( source : imdb ) read more »
within 1 month you will receive a free car . a draw has just been concluded in hong kong last weekend ( we contacted you via your email address ) .
during the first week after car - bcma infusion , we noted a striking decrease in patient 10’s serum iga level ( figure 2g ) . serum iga became undetectable and remained undetectable 14 weeks after car - bcma t - cell infusion . a dramatic eradication of mm from the bone marrow occurred . ihc for the plasma cell marker cd138 showed a complete absence of bone marrow plasma cells 4 and 8 weeks after car - bcma t - cell infusion ( figure 2e - f ) . four weeks after car t - cell infusion , a population of t cells was detected in the bone marrow ( figure 2h ) ; 31 % of bone marrow t cells expressed car - bcma by flow cytometry ( figure 2i ) . the serum and urine immunofixation electrophoresis tests for monoclonal iga - κ became negative after treatment and remained negative 14 weeks after car - bcma t cell infusion . fourteen weeks after car - bcma t - cell infusion , multicolor flow cytometry did not detect mm cells in the bone marrow , which confirmed a stringent complete remission ( cr ) . as expected , normal plasma cells were also absent from the bone marrow 14 weeks after car - bcma infusion . nineteen weeks after infusion , the serum immunofixation electrophoresis remained negative , but a monoclonal iga - κ protein was detected in the urine . this indicated a relapse of mm . subsequently , bcma + malignant plasma cells were detected in the bone marrow ; car - bcma t cells were not detected in the bone marrow at the time of relapse .
after receiving cd19 - targeted car - t cell therapy , all patients with mll - b - all achieved cr in the marrow by flow cytometry ; however , 2 of 7 patients relapsed , both with a myeloid phenotype leukemia approximately 1 month after car - t cell infusion . pathology findings are summarized in table 1 and figure 1 .
patient 10 experienced pancytopenia associated with a hypocellular bone marrow ( figure 2e ) . he had an absolute neutrophil count ( anc ) of 370 immediately before the car - bcma t - cell infusion . the anc remained < 500 for 40 days after car - bcma t - cell infusion , and the patient had an episode of bacteremia associated with transient hypotension during this neutropenic period . the patient also experienced transfusion - dependent thrombocytopenia for 9 weeks after car - bcma infusion . fourteen weeks after car t - cell infusion , patient 10 had a normal anc , and he had not required a platelet transfusion in > 6 weeks , although his platelet count remained decreased at 43 000 / μl .
it ' s inspiring to see films like this every once in a while - hyper low - budget triumphs of the indie spirit . occasionally hilarious and usually entertaining , except for a few kind of boring patches , blood car is an entertaining testament to the successes that independent film making can produce . it ' s one of those movies that makes you want to go out and film your own .
car - bcma t cells specifically recognized bcma in vitro and exhibited antimyeloma activity in humans . ( a ) diagram of the msgv - 11d5 - 3 - cd828z γ - retroviral vector encoding the anti - bcma car ( car - bcma ) is shown . car - bcma contained the 11d5 - 3 anti - bcma single chain variable fragment ( scfv ) , cd8α hinge and transmembrane regions , the cytoplasmic portion of the cd28 costimulatory moiety , and the cd3ζ t - cell activation domain . ( b ) car - bcma expression on the surface of the infusion t cells of patient 10 was detected by staining with a pe - bcma - fc protein reagent . the plot is gated on live cd3 + lymphocytes . ( c ) demonstrating specificity , the pe - bcma - fc reagent did not stain pbmcs that were not transduced with the car - bcma gene . ( d ) car - bcma t cells of patient 10 were cultured with target cells that either expressed bcma ( bcma - k562 and rpmi8226 ) or did not express bcma ( ngfr - k562 and ccrf - cem ) . the car - bcma t cells of patient 10 specifically released ifnγ in response to bcma - expressing target cells in vitro . ( e ) patient 8 who had mm that was progressing despite 8 prior lines of therapy obtained a very good partial remission ( vgpr ) after infusion of car - bcma t cells . positron emission tomography–computed tomography scans from before and after treatment show elimination of a large number of mm bone lesions . ( f ) patient 8’s free κ light chains level decreased after car t - cell infusion as the mm entered a vgpr and then increased with progression of the mm . the serum bcma protein level followed a pattern similar to that of the serum free κ light chains .
administration of lymphodepletion chemotherapy followed by cd19 - specific chimeric antigen receptor ( car ) –modified t cells is a remarkably effective approach to treating patients with relapsed and refractory cd19 + b - cell malignancies . we treated 7 patients with b - cell acute lymphoblastic leukemia ( b - all ) harboring rearrangement of the mixed lineage leukemia ( mll ) gene with cd19 car - t cells . all patients achieved complete remission ( cr ) in the bone marrow by flow cytometry after cd19 car - t - cell therapy ; however , within 1 month of car - t - cell infusion , 2 of the patients developed acute myeloid leukemia ( aml ) that was clonally related to their b - all , a novel mechanism of cd19 - negative immune escape . these reports have implications for the management of patients with relapsed and refractory mll - b - all who receive cd19 car - t - cell therapy .
in a near future where gasoline costs more than $ 30 a gallon , schoolteacher archie andrews invents an engine that runs on human blood . needless to say , complications arise when his revolutionary creation requires fresh supplies of fuel .
patients received lymphodepletion chemotherapy , followed by infusion of autologous cd19 car - t cells , according to 2 clinical trial protocols ( nct01865617 , nct02028455 ) . t cells were modified using a car construct incorporating a truncated human epidermal growth factor receptor as a marker of transgene expression , which enabled enumeration of car - t cells . 8 evaluation of leukemic blasts by flow cytometry , fluorescence in situ hybridization ( fish ) , g - banded karyotyping , and chromosomal genomic array testing ( cgat ) was performed in clinical laboratory improvement amendments–certified laboratories , and deep sequencing of the igh gene was performed by adaptive biotechnologies ( seattle , wa ) . quantitative polymerase chain reaction for vector sequence was used to enumerate integrated car transgene in car - t cells and myeloblasts . these studies were conducted with approval of the institutional review boards of fred hutchinson cancer research center and seattle children’s hospital and in accordance with the declaration of helsinki .
he sandal was reportedly found in 2012 at the site where konstantinos
dino
barkas was - operating a digger , while the car was - discovered last year at another spot .
so , with this flagrant breach of both chronological logic and the fourth wall , blood car immediately establishes its absurdist tone . alex orr’s feature debut was in fact completed in 2007 , winning acclaim and awards at various festivals before going straight to dvd in the us – but in the half decade that it’s taken to get its theatrical release in the uk , the film has left its influence on quentin dupieux’s left - field ‘road movie’ rubber and dean francis’s more conventional highway horror road train ( both 2010 ) , the former similarly featuring a killer car part , the latter a carnivorous engine .
we detected soluble bcma in the serum of all 12 patients before treatment ( figure 4d ) . serum bcma decreased after car - bcma t - cell infusion in the patients with the most impressive antimyeloma responses , patients 8 , 10 , and 11 ; in contrast , serum bcma did not decrease substantially after car - bcma t - cell infusion in the other patients .
six civilian witnesses testified that the overhead lights on officer neubauer ' s car were not turned on , while three city police officers , including neubauer , testifies that the lights were operating .
all patients experienced cytopenias attributable to the conditioning chemotherapy that patients received on this protocol and the extensive prior therapy patients had received before protocol enrollment ; patients 10 and 11 had cytopenias clearly more prolonged than expected from the chemotherapy that they received . toxicities are listed in table 2 . toxicities attributable to car - bcma t cells were minimal in patients treated on the 0 . 3 × 10 6 car + t cells / kg dose level . on the 1 × 10 6 car + t cells / kg dose level , patients 4 and 5 had signs and symptoms of crs including mild fever and tachycardia . patient 8 had significant fever , tachycardia , and hypotension among other toxicities , but the 3 other patients receiving 3 × 10 6 car + t cells / kg had mild toxicity . on the 9 × 10 6 car + t cells / kg dose level , patients 9 and 10 both had a variety of grade 3 and 4 toxicities .
when the transplant failed about three months later , “we thought it was a death sentence , ” says andy . but greta qualified for experimental car - t therapy , available only to patients with no other recourse . in august 2014 she received a dose of her own t cells , extracted from her blood , modified and expanded outside her body , then infused back into her bloodstream to zero in on the life - threatening cancer .
greta and charlotte were chattering in the back seat of the family car when i spoke to her parents recently . they were driving from their home in portland to a weekend vacation in canada .
to receive your free car all you need to do is send us your 1 . full name 2 . address / contact number 3 . country of origin 4 . occupation 5 . email .
patient 11’s serum igg - λ m - protein started to decrease after car - bcma t - cell infusion and decreased to the point that it was not quantifiable at last follow - up 28 weeks after car t - cell infusion . the only evidence of mm at last follow - up was the serum igg - λ m - protein that was detectable only by immunofixation electrophoresis . the serum free λ light chains that were another marker of the patient’s mm became undetectable early after treatment ( figure 3g ) . patient 11’s most recent formal myeloma response was vgpr . a bone marrow biopsy 4 weeks after the car t - cell infusion revealed a hypocellular bone marrow and complete elimination of bone marrow plasma cells ( figure 3e ) . the patient was platelet transfusion dependent from day 2 until day 27 after car t - cell infusion . eight weeks after the car t - cell infusion , bone marrow cellularity was recovering , and plasma cells remained completely absent ( figure 3f ) . absence of mm cells and normal plasma cells from the bone marrow was confirmed by multicolor flow cytometry 4 , 8 , and 25 weeks after car t - cell infusion . four weeks after car t - cell infusion , a large population of t cells was detected in the bone marrow ( figure 3h ) ; 19 % of bone marrow t cells expressed car - bcma by flow cytometry ( figure 3i ) . less than 8 weeks after the car t - cell infusion , all of patient 11’s toxicities except decreased lymphocyte count had improved to grade 1 or resolved , and he had returned to full - time employment . in accordance with continued absence of plasma cells in patient 11’s bone marrow , the serum immunoglobulin levels steadily decreased after car - bcma infusion . twenty - eight weeks after car t - cell infusion , the serum igg was 388 mg / dl ( normal range , 700 - 1600 mg / dl ) , the serum iga was below detectable limits , and the serum igm was 15 mg / dl ( normal range , 40 - 230 mg / dl ) . because of the low immunoglobulin levels , we initiated immunoglobulin replacement with intravenous igg .
' ' blood simple ' ' contains much blood and gore , and the coens say they are surprised the critics haven ' t taken them to task for the violence . ' ' but the violence is bound up in the story , rather than gratuitous , ' ' joel said . ' ' it ' s very different from a horror movie where the characters are mechanically set up to be slaughtered . we have no slasher scenes . this is more of a story movie . ' '
making the most of his low budget and fully embracing a b - picture sensibility , orr loads his film with broad caricatures , low humour and hilariously surreal ( and politically incorrect ) digressions . but this is an exploitation movie about exploitation , and its disarming goofiness and transgressive vulgarity eventually give way to images of state execution and infanticide – all in the name of the american dream – that are shockingly serious , if still played for uncomfortable laughs . a speech of frankly insane justification delivered by another government agent ( matt hutchinson ) near the film’s end evokes dr . strangelove ( 1964 ) – and indeed blood car is similarly apocalyptic in its lampooning of post - millennial anxieties , with a gleefully cynical finale pointing to a dead - end future for all but a self - serving political elite . a couple more weeks down the road , blood car will be a cult classic .
this rumor has taken on many forms , claiming that coca - cola , due to its acidic nature , can be used to clean toilets and corrosion from car batteries , loosen a rusted bolt and remove rust spots from car bumpers , remove grease from clothing , clean road haze from windshields , clean highways after traffic accidents , cook a steak , dissolve teeth , and bake a moist ham .
but the novartis car - t wasn’t what cured greta . she was too young at the time to enter the experimental trial for that program . instead , her parents enrolled her in a study for a different car - t program , at seattle children’s hospital , which was accepting patients as young as a year old . greta ( pictured above , with her sister charlotte , 6 , behind her ) first had to put on weight—lots of french fries and milkshakes , says her mother , maggie—then go through another round of chemo , but she managed to hang on for her car - t treatment .
progression of bcma - negative mm is a potential problem after car - bcma t - cell therapies . we assessed bone marrow mm cells for bcma expression after car - bcma t - cell infusion by ihc ; the before and after treatment bcma expressions are summarized in supplemental table 4 . a partial loss of bcma expression by malignant plasma cells was detected only in patient 7 ( supplemental figure 1 ) .
the city of des plaines alleged that debra krall was under the influence when she made a left turn into the path of a police car driven by officer lori neubauer on sept . 23 , 1995 .
patient 11 received 5 prior lines of therapy before enrolling on the car - bcma protocol . his most recent therapy prior to enrollment was cybord ; during his only cycle of this treatment , patient 11’s mm progressed . before car - bcma infusion , 80 % of the cells in the patient’s hypercellular bone marrow were bcma + plasma cells ( figure 3a , b , d ) . four hours after infusion of 9 × 10 6 car - bcma t cells / kg , he developed a sustained fever that was associated with an elevated crp ( figure 3c ) . worsening tachycardia , hypoxemia , and dyspnea developed over the next day , so 25 hours after the car t - cell infusion , tocilizumab was administered . this patient also had grade 3 delirium without other neurologic toxicities . four hours after the tocilizumab was administered , the dyspnea improved , and the temperature and heart rate decreased temporarily . a second dose of tocilizumab was administered 5 days after the car t - cell infusion . patient 11 had adrenal insufficiency at the time of protocol enrollment , and he received stress - dose intravenous hydrocortisone at doses varying from 25 to 75 mg every 8 to 12 hours between day 0 and day 13 after car t - cell infusion .
car - bcma t cells were detected by flow cytometry after staining with a phycoerythrin - labeled bcma constant - fragment reagent ( pe - bcma - fc ) ( figure 1b - c ) . car - bcma t cells were also detected by performing quantitative pcr ( qpcr ) . enzyme - linked immunosorbent assays ( elisa ) for interferon γ ( ifnγ ) were performed on supernatants from cultures of car - bcma t - cell samples plus target cells . interleukin - 6 ( il - 6 ) elisas , soluble bcma elisas , and multicytokine assays were performed on patient serum . methods for all assays are in supplemental methods .
garry shandling died from a blood clot , tmz reported on tuesday after it obtained a copy of the comedian’s autopsy report . the outlet said that shandling also had xanax , hydrocodone and oxycodone in his system at the time , attributed to a recent dental surgery .
when i say
two of three bonus levels i saw ,
that ' s because i couldn ' t get very far in the game . i couldn ' t find a certain npc on the second level which spans the entire city and i ultimately decided i wasn ' t willing to put up with the hide - and - seek games , indestructible obstacles , and crappy car physics to find how many more inventive parallels the developers decided to draw between blood and feces .
immunotherapy with t cells that are genetically modified to express a cd19 - specific chimeric antigen receptor ( car ) represents a promising approach for patients with refractory b - cell acute lymphoblastic leukemia ( b - all ) .
we have previously shown that anti - cd19 car t cells administered without chemotherapy can cause cytopenias in patients with high disease - burden all . 23 of the patients receiving car - bcma t cells , patient 10 experienced prolonged pancytopenia and patient 11 experienced prolonged thrombocytopenia . we hypothesize that the cytopenias experienced by these 2 patients were a cytokine - mediated phenomenon caused by high levels of cytokines produced when car - bcma t cells contacted high burdens of bone marrow mm ; however , bystander perforin / granzyme - mediated killing of hematopoietic cells could also be speculated . both of these patients were cytopenic prior to car - bcma t - cell infusion , which probably contributed to the severity of the cytopenias after car - bcma t - cell infusion ( supplemental table 7 ) . the chemotherapy that patients received as part of this protocol is expected to cause cytopenias , and the extensive therapy that the patients had received prior to protocol enrollment probably contributed to chronic bone marrow impairment in some patients . we never observed bcma expression on any bone marrow cells except plasma cells after performing ihc staining on bone marrows from 85 patients .


nam naadu ( english : our country ) is a 2007 tamil film starring sarath kumar and karthika mathew in lead roles and is the remake of the malayalam film lion.dubbed in hindi as hukumat ki jung 2 .

the film received negative reviews and failed to replicate the success of the original .

nam naadu ( 2007 film )

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nam naadu is a 2007 tamil film starring sarath kumar and karthika mathew in . . .
nam naadu is a 2007 tamil film starring sarath kumar and karthika mathew in lead roles and is the remake of the malayalam film lion .
as a whole , taking the whole film into consideration , nam naadu is a film for a political cause and also a commercial film that can be watched to kill the time and not more than that . nam naadu fails to hit bull’s eyes .
if you want to answer the questions ,
who starred in the movie nam naadu ?
and
what is the full cast list of nam naadu ?
then this page has got you covered .
this cast list of who was in nam naadu includes both lead and minor roles . ( 11 items )
nam naadu cast list , listed alphabetically with photos when available . this list of nam naadu actors includes any nam naadu actresses and all other actors from the film . you can view additional information about each nam naadu actor on this list , such as when and where they were born . to find out more about a particular actor or actress , click on their name and you ' ll be taken to page with even more details about their acting career . the cast members of nam naadu have been in many other movies , so use this list as a starting point to find actors or actresses that you may not be familiar with .
song : kadhal ennum thotathil .
nam naadu
is a tamil film and is the remake of the malayalam film lion . music : srikanth deva . released : september 2… | pinteres…
high quality content by wikipedia articles nam naadu ( english : our country ) is a tamil movie released in 2007 , which stars sarath kumar and karthiga in lead roles and is the remake of the malayalam film lion .
post pacchaikili mutthucharam , more things were expected from sarath kumar but he is back again with the same story of being a politician . apprehensively with more and interesting star casts , much was expected from this film , but nam naadu has not made up to its expectations . remakes must always go with the policy with the saying ‘better than the best’ and nam naadu being the remake of malayalam flick , there’s nothing special here .
thaai naadu ( 1989 ) tamil movie cd - rip 320kbps mp3 songs music by manoj gyan - starmusiq . com
gorringe , hugo and irene rafanell . 2007 : “the embodiment of caste . ” sociology 41 ( 1 ) : 97–114 .
thottal poo malarum ( ) is a 2007 tamil romance film written and directed by p . vasu , starring his son sakthi vasu and gowri munjal , two newcomers , in lead roles , whilst rajkiran , sukanya , nassar , vadivelu and santhanam played supporting roles . music is composed by yuvan shankar raja . the film was released on 3 august 2007 and became an average grosser .
movie title - - - nam naadu unknown facts imdb rating and complete report imdb rating - - 4 . 1 cast - - pragathi riyaz khan sarath kumar as muthazhagu sriman below actors passed away - - manivannan died on 15 - jun - 2013 movie details - - music by - srikanth deva produced by - singanamala ramesh release date - 21 - sep - 07 story - - a man not only alienates himself from his family but also endangers his life when he decides to stand for elections . review - - kollywood today wrote as a whole taking the whole film into consideration nam naadu is a film for a political cause and also a commercial film that can be watched to kill the time and not more than that .
srikanth deva’s musical score is not a commendable job and none of the songs out of 5 have come out . it would have been nice if director had shown his involvement for musical part of this film . getting to other technical aspects of nam naadu , the works are not quite appreciable and as mentioned earlier , it reveals of director’s non - involvement in the post - production .
these films revealed the hidden caste biases of dravidian politics and film - making .
caste assertion , in other words , is both reflected and reinforced through film .
in 2007 , he returned in the lead role in
thottal poo malarum
again directed by his father p . vasu ; however , the film was unsuccessful at the box - office . since then he has featured in the romcom
mahesh saranya matrum palar
, another unsuccessful film . vasudevan appeared in a supporting role in
ninaithale inikkum
where his role was appreciated by critics , and the film managed to break even .
thaai naadu is a 1989 tamil comedy , drama film , directed by r . aravindraj and produced by chemba movies . this film stars sathyaraj , radhika , m . n . nambiar , jaishankar , captain raju , srividya , janagaraj , nassar in the lead role . the films soundtrack and background score were composed by manoj gyan with lyrics by aabavanan .
after the huge success of enga veetu pillai , when mgr was considering his entry into politics , he signed up with reddy to remake a telugu hit kathanayakudu , which was made as nam naadu in tamil . when nam naadu released , both reddy and mgr went to mekala theatre to watch the reaction of the viewers . there was a scene in which mgr was being welcomed after his victory in the elections . the audience was screaming , clapping and whistling and asked the theatre owner to repeat the mass scene . after witnessing the cheers ( that proliferated once scene was repeated ) , the superstar hugged the director and with tears of joy , he said , “thanks reddiar ! i have received the people’s acceptance . ”
the wayside seller of hooch ( the film ' s producer rochak pandit played that role ) .
today , this practice has been stopped as every film gets released across theatres as the distributor wants to make the maximum earnings from the first weekend . in 2007 , ajith’s superhit billa set the trend when it got screened at both abirami and sangam multiplexes - a first in this area .
it is important to note here that such films are not confined to the south . in the film
mard ( english translation : male or man or macho ) is a 1985 hindi action film , starring amitabh bachchan and amrita singh and directed by manmohan desai . it was the highest earning film of 1985 .
srivathsan , a . 2007 . “ethnography of violence . ”’ the hindu , april 29 . retrieved october 28 , 2015 ( urltoken sundaymagazine / ethnography - of - violence / article2275175 . ece ) .
( tamil film - stars are popular not only by virtue of their cinematic appeal but also because of the close links they maintain with political parties and the checkered political career of the tamil film industry itself ) .
1950s tamil film was largely used as a platform to articulate dravidian identity and tamil nationalism . the founding of the
after debuting in the tamil film ezhai padum padu in 1950 , he acted in more than 250 films . he predominantly was cast in supporting roles in films of m . g . ramachandran like nam naadu , en annan , thedi vandha mapillai and others . later starred in films including rajinikanth ' s thambikku entha ooru . the scenes in which he appeared as a mahout were popular in the 1980s . though he has made many films , he became famous for his dialogue in thottal poo malarum ( varum , aanaa varaadhu . . . ) with vadivelu .
the film is a family entertainer , and steers clear of sex and violence . but somehow , it also guarantees that many of the main characters in the film act incredibly stupid . or rather , there is an assumption on the part of the filmmaker that audiences are stupid and the film needs to be on their level to evoke a response .
remaining part of the film is about how he sets out to cleanse the society from all its corruptions and illegalities .
sivathamby , karthigesu . 1981 . tamil film as a medium of political communication . madras : new century book house .
ramesh babu under the banner of kanaka rathna movies after the successful venture with pokkiri has produced this movie . well , one thing that is clearly viewable in this film is that sarath kumar has well utilized this film to convey his political ideologies .
pandian , anand . 2008 . “cinema in the countryside : popular tamil film and the remaking of rural life . ” pp . 124–38 in tamil cinema : the cultural politics of india’s other film industry , edited by s . velayutham . abingdon : routledge .
for the music of the film , p . vasu teamed up with composer yuvan shankar raja for the first time . the soundtrack was released on 23 june 2007 by rajinikanth and kamal haasan . it features 6 tracks , whilst ' kavignar ' vaali had written the lyrics for all the songs , but for
kadatharen naan unnai
, which had lyrics written by snehan .
there are some neo - nativist films where the metaphor of traditional masculinity collapses to become an object of comic relief . in the film
( devendra film company ) . the first production they mooted was to depict one of their leaders , thekkampatti balasundarasu , to be titled
abirami , however , never released hindi films until the reopening of one of their screens , post renovation ( they renovated each of their screens one by one to make sure business does not stop ) . their first big hindi release was in diwali 2007 when they released shah rukh khan’s om shanti om in their refurbished swarna sakthi abirami . but abirami did not stop here , he even distributed the film in chennai . this move sent shock waves in the theatre business , with ega cinemas , which specialized in hindi films , taken by surprise . ega cinemas released only one film - saawariya - that diwali , missing out on the high profile srk film .
forrester , duncan . 1976 . “factions and film stars : tamil nadu politics since 1971 . ” asian survey 16 ( 3 ) : 283–96 .
( a large sickle ) and dead men lie all around . there is neither remorse nor fear in the eyes of the male protagonist . why should he ? after all , violence is natural to the caste he belongs to , so believes tamil cinema ( srivathsan 2007 ) .
the ways in which film plots feed into politics was graphically illustrated in 2013 , when dr . ramadoss , the founder - leader of the vanniyar centered
the filmography in 3m films reinforces this attempt through the juxtaposition of national heroes such as subhas chandra bose , thevar leaders such as muthuramalinga thevar and the film’s protagonist , or through scripts that assert the valor of the thevars . the culmination of 20 years of caste - based cinema may be seen in the film
hardgrave , robert . 1973 . “politics and film in tamil nadu : the stars and the dmk . ” asian survey 13 ( 3 ) : 288–305 .
one question that might arise at this juncture is how the film - makers communicate the caste of the characters to the audience . in some instances , as with
, the very name of the film or the character locates them within a particular community . in others , however , it is the use of attire , mannerisms and bearing that connote particular castes . one important caste marker in the context of dominant masculinity , of course , is the moustache ( gorringe and rafanell 2007 ) . in consideration of the physical performance of masculinity , one of the most visible and effective practices—the styling of facial hair—comes to the fore in these films . in
sarath kumar was once a big action star . his movies were known for their stunt sequences . but in this film , the stunt sequences by super supraiyan are very ordinary .
in the end a compromise was reached in which the title of the film was changed and the plot line subtly altered to avoid being seen as a direct follow - up .
on the downside the film is too long , the politicians and the baddies are stereotypes whom you have seen in earlier films , the heroine karthika known for her girl - next - door type roles in malayalam lacks glamour , is uncomfortable in hip clothes and singing dream songs ! technically the film is tacky with far too many goof - up ' s .
ramesh kanna , who acts as a comic side kick of the corrupt minister has also written the script of the film . he has laced the film with some recent political happenings and makes barbed references to ruling and opposition parties in the state . nassar playing the corrupt minister aalavanthan is very good , while sarath as his son muthu is dashing and looks great in designer khadi .
they argue that the hero’s courting of arrest at the end of the film “signifies a total submission of the authority of the village community to state power . ” in line with our analysis of
grasping the inter - relationship between filmic eulogies and caste violence , dalit movements have sought to contest dominant depictions of caste pride and valor . this is best illustrated in the controversy surrounding kamal hassan’s film
a semi - biographical account of yip man , the first martial arts master to teach the chinese martial art of wing chun . the film focuses on events surrounding ip that took place in the city of foshan between the 1930s to 1940s during the second sino - japanese war . directed by wilson yip , the film stars donnie yen in the lead role , and features fight choreography by sammo hung .
director ar . suresh main cast r . sarathkumar ; karthika ; nasser ; ponvannan ; charan raj genres action , drama description nam naadu is a action based movie . it starts with aalavandhar ( nasser ) a corrupt politician who holds the post as education minister and wants to become the chief minister . he is supported by his son - in - laws , sathya ( saranraj ) ips officer who runs a finance company and ilamaran ( ponvannan ) ias officer , the district collector . with the idea of his in - laws , aalavandhar tries to disturb peace in state and make situation against the cm . muthazhagu ( sarath kumar ) a honest youth wing leader of the same ruling party learns and opposes the move of his father and he stands by and for the . . .
in 2007 , when ‘abirami’ ramanathan distributed rajinikanth’s sivaji in chennai , he brought in a new revolution by releasing in the film in record number of screens . in all other areas of chennai , there was wide showcasing but in purasawalkam area , abirami simply monopolized the distribution . while they played the rajinikanth blockbuster in all four screens at abirami , they did not give a single show to sangam . sangam reciprocated when they started distributing movies like vijay sethupathy’s pizza . the cat and mouse game followed when superhits kalakalappu and kumki were not released at abirami , while sangam played it exclusively .
thus , when a film cast them in a less glorified and flattering light they were quick to respond . in madurai , theni and kovilpatti districts , for instance , cinema halls were damaged during the screening of
( we must learn to live as one , 1992 ) which openly discusses dalit questions . however , not only is it a comedy , it stands as an exception which “shatters the stability of the delicate logistical constructs around which are organized the discursive hegemonies of caste society” ( srinivas and kaali 1998 : 221–22 ) . srinivas and kaali are right to point to the utopian aspirations embodied in the film , but it is important to stress that for the most part dalits are not only portrayed in humiliating ways , their options in film making are limited . when the name of a . l . vijay’s film starring the actor vikram was announced as
nasser , one of the finest character actors in tamil cinema , plays the father with his usual flair . his performance rises above the level of the film but he seems to be bogged down by a pedestrian script .
the music was scored by yuvan shankar raja , teaming up with director v . priya again after
kanda naal mudhal
( 2005 ) . the soundtrack was released on 23 august 2007 by vivek oberoi . it features 5 tracks , including a retune of the yesteryear hit song
andru vandhadhum
from the m . g . r . - starrer
periya idathu penn
, being just the second song to be retuned after a . r . rahman ' s
thottal poo malarum
from the film
new
. noticeably , singer shankar mahadevan lent his voice for three songs . lyrics were provided by thamarai .
n am nadu , sarath kumar ' s first film after he launched his own political party in tamil nadu , is about the rise of a young politician whose ethics are sharply in contrast with his father ' s ambitions .
( battle rooster , 2005 ) the hero makes no such claim , but the film illustrates both his thevar caste and his madurai location to explain his ability to take on and defeat the villains from elsewhere in the state .
kaali , sundar . 2000 . “narrating seduction : vicissitudes of the sexed subject in tamil nativity film . ” pp . 168–90 in making meaning in indian cinema , edited r . vasudevan . new delhi : oxford university press .
formal experiments in new cinema the film enters dream - space . balo presumably dreams of jinda at home , raped , and it is unclear as to whether the arrival of the husband is part of her dream or not .
in the dramatic finale to the film , kamal hassan vanquishes the villain in a gory beheading scene that was greeted with whoops and cheers in the theatres of madurai . one of the authors experienced the same film in the western city of coimbatore where the audience were muted in their response and there were murmurings about the excessive use of violence . whilst audience participation in the form of cheering , whistles and applause is widespread , it is the celebration of violence that stands out here . in pandian’s ( 2015 ) ethnography of film - making in tamil nadu he emphasizes the silence during harrowing scenes . it is our contention that the violence is celebrated here due to its association with caste dominance .
is a very different film to those described above , but it still re - asserts the hegemonic narrative or common - sense that equates thevars with honor . the thevar caste , in other words , in the words of a song from
even last week , he sprung a surprise on the entire industry by waiving off the most talked about online booking charges in his theatre , which many believe has come from the right person as he heads the tamil film chamber of commerce .
and , belying the actor’s claims of neutrality , debates about the film ended up with “puthiya tamilagam opposing it and splinter groups of the all - india forward bloc [ a thevar front ] and some mukkulathor outfits offering to provide protection . ”
krishnan , rajan . 2008 . “imaginary geographies : the makings of ‘south’ in contemporary tamil cinema . ” pp . 139–53 in tamil cinema : the cultural politics of india’s other film industry , edited by s . velayutham . abingdon : routledge .
for the last few years , abirami is often the first theatre to open advance bookings for a blockbuster film . they were also the first to stop advance bookings for films like vishal’s madha gaja raja and kamal haasan’s vishwaroopam , signalling postponement . while abirami is one of the pioneers in sound technology ( they installed dolby sound system even before the release of kamal haasan’s kurudhi punal - the first tamil film mixed with this sound ) , today they have the latest laser projection for their screens .
) of the hero or his family is questioned or challenged . crucially for our argument , the cinematic offerings most closely adhering to the 3m formula have not only provided a discourse through which to discuss caste , but also offered a template according to which dominant castes have sought to reimagine and reinforce their dominance . in metonymically linking film stars to political figures , such films suggest that thevars have a right and a duty to uphold their honor . for example , the title song in the film
regeneration is a 2010 american documentary film written and directed by phillip montgomery that looks at the issues facing today ' s youth and young adults , and the influences that contribute to america ' s current culture of apathy toward to political and social causes .
likewise , whilst volumes have been devoted to discussing the significance of caste in tamil politics , there has been less attention paid to the ways in which caste is played out in the cultural sphere of film ( but see srinivas and kaali 1998 ) .
interestingly , anna nagar despite being a big residential area , does not have a single movie hall . this is because the highly affluent residents never visited a cinema in the 1990s , preferring to watch films on their vcrs at home . and while there were no proper theatres in the ‘90s , from the early 2000s , it became impossible to invest in a plot and construct a theatre in anna nagar . the screens in aminjikarai served as a small alternate for the residents ! for example , vijay’s 2007 blockbuster pokkiri had a 100 - day re - run at aminjikarai lakshmi , where the film released post its 100 - day run in release centres . this was a new record that was previously owned by rajinikanth’s annamalai in 1992 !
( master , our thevar master ) excised from the film . more recently , followers of militant pallar founder - leader of federation for the progress of tamil people , john pandian , smashed glass cases in a cinema hall during a screening of c . sundar’s
move on is a road movie like no other , because it is inspired by film fans from all over europe ! this breath - taking movie directed by asger leth features mads mikkelsen on a secret mission in 8 episodes , each taking place in a different european country .
tsv hari of urltoken described the film as
very ordinary fare ,
adding that
sakthi certainly deserved better .
m bharat kumar of
news today
called it a
mediocre offering
with
predictable sequences ,
noting that
the son seems to have delivered the goods well , while the father has failed as a director .
however ,
indiaglitz
described it as a
feel - good youthful entertainer
with an
intelligent screenplay and pacy narration
that is
sure to appease film - buffs .
was deliberately used to mobilize thevars during the pallar - thevar riots that flared up repeatedly between 1995 and 1998 . thevars in riot torn villages screened the film ( rajangam 2008 : 60 ) , and its songs were used to instigate inter - caste violence ( ravindran 2008 ) .
to understand this genre , however , we need to start with the archetypal celebration of thevar dominance . according to krishnan ( 2008 ) , “it is a kamal hassan [ one of the two most famous tamil actors , and not himself a thevar ] film of high authenticity markers called
where signs , weapons and dialogue all speak to the caste’s dominance . the advertising for the film reinforced the association between caste and violence . in madurai , which has a stronger visual culture than other cities in tamil nadu , a 40 - foot cut - out was installed showing the
‘abirami’ ramanathan’s pet child - the four - screen multiplex abirami mega mall– has seen the industry evolve . the abirami complex entered business during the early 1970s , at a time when the multiplex boom started in chennai . starting 2007 , abirami took up each screen for renovation and brought up different theme - based theatres . they even introduced a new jargon in cinema trade - the ‘7 star theatre’ . there is a waiter on call to deliver you dinner and there are recliner seats , which can be turned into a bed while you watch your favourite flick .
( the hunter , babu sivan , 2009 ) , for instance , the fact that the hero is a college student is an irrelevance next to his ability to fight . “if i hit you” one of the film songs puts it , “you won’t be able to bear it”—thus asserting his superiority over the villains .
( god’s chosen son , 2011 ) , there was an outcry from thevar groups who have trademarked that phrase for pasumpon muthuramalinga thevar and were particularly infuriated by the fact that the main actor in question was a dalit who is celebrated by pallar youth as one of their own . eventually the film was released as
( son of thevar , bharathan 1992 ) —meaning ‘son of thevar’—that can be said to have inaugurated the era of the south being represented as primarily a sickle bearing space . ” stalin rajangam , a dalit cultural critic who has written extensively on the caste component and narrative structures of tamil film concurs ; he says that
was if anything the reverse . films , once they are released , have a life of their own that is beyond the intentions and direction of the film makers . in this sense , we find krishnan’s reading of the films somewhat limited . at several points , for instance , he makes arguments to the effect that :
dhoni’s ability to absorb pressure comes to the fore even as a captain and a keeper when his team defends scores . who can forget his gamble to give joginder sharma the last over in the 2007 t20 world cup final ? or his lightning wicket - keeping skills which made him find the split second when the batsman’s foot was off the ground to dismiss ian bell in the 2013 champions trophy final and sabbir rahman in the 2016 t20 world cup match ? or his street - smart thinking evident in removing his gloves and running to get mustafizur rahman run - out in the last ball of the same t20 match ?
well , director suresh seems to have good rapport with sarath kumar for he has successfully directed 3 films for him . going for the remake , the film remains drier at few points and that’s quite boring for the audience to sit and watch it with patience . the only convincing thing over here is the dialogues penned by ramesh khanna and he has carefully handled the lines pertaining to situations . but few dialogues in the film tend to reflect some of the real life incidents in present day politics of tamil nadu . also mentioning of names like ‘amma’ and pricking indirectly some of the political personalities is more punching and that’s reveals sarath’s notion of passing the ideologies .
pandian argues that film has “come to provide a language for the social life of kinship and attachment” ( 2008 : 131 ) . certainly , many of these films have been adopted by thevars in southern tamil nadu through posters , symbols , banners and the playing of film songs and dialogue at cultural events . as kaali ( 2000 : 186 ) argues , “identification with ego - ideals on the screen need not inevitably entail ‘misrecognitions of self , ’ but , in many cases , could involve elements of empowerment” and identity change . the portrayal of thevar violence and valor on screen and their positive reception , serve to embolden thevars and legitimize their use of violence .
indeed , film historian theodore baskaran ( 1996 : ii ) goes as far as to argue that : “tamil cinema has grown to become the most domineering influence in the cultural and political life in tamil nadu . ” film stars have a larger - than - life presence in the real world and female stars have been deified during their active period in the industry . the emergence of cinema in tamil nadu and its subsequent role in nurturing and promoting a dravidian identity and politics have been the focus of several monographs ( see forrester 1976 ; hardgrave 1973 ; pandian 1992 ) . that history , whilst relevant , is not our focus here and so we refer readers to the aforementioned texts .
purasawalkam is often considered as the signal provider for the entire cinema industry . if there is uncertainty over the release of a film , the opening of advance bookings at abirami mega mall is considered a green signal for the movie’s release . the highly reputed and influential veteran ‘abirami’ ramanathan is the trade’s powerhouse and all roads lead to him for crucial decisions .
( love , 2004 ) —a low budget film about a romance between a couple of unspecified castes who are , nevertheless identifiable as a thevar girl and a dalit boy . when the couple is discovered , the girls’ family beat the boy to a pulp . crucially , for our argument , the representations on screen are transposed into the caste politics of everyday tamil nadu :
while the modern state is compromised by electoral politics allowing such hooligans to exercise control over politicians or elected representatives , it is nevertheless capable of producing neutral individuals like saami [ an honest and heroic policeman from the 2003 film of the same name ] in its administration who can annihilate the anti - state bodies and their caste - criminal networks ( 2008 : 142 ) .
the power of this common - sense argument is such that it is not just thevar actors , producers and cinematographers who adopt this formula . the commercial success of such films has made them immensely popular , which has a ripple effect that influences the way other films focused on southern tamil nadu are shot . even non - thevar directors like gangai amaran are not immune . his film
thus , even in the overt condemnation of caste violence , dalits are stripped of their agency and rendered passive recipients . other popular film tropes similarly conspire to relegate dalits to the margins . the emphasis on bull - taming is a case in point , since dalits were historically barred from taking part in such contests and have only begun to enter them since the dalit struggles of the 1990s .
following caste - based challenges to dravidian politics from intermediate caste groups like the thevars and vanniyars—and their demands for a greater allocation of resources and increased political recognition—the 1990s saw the flourishing of nativist ( a form of social realism ) cinema that openly celebrated and portrayed caste identities and characters . it is only in the 2010s that we see the film industry starting to acknowledge and represent dalit struggles in films such as
that the close association between caste and valor is to the fore . when kamal hasan’s character , who has been in singapore for many years , returns to tame a bull as though he has never been away the film suggests that caste is an innate and immutable essence rather than a code of conduct . this maps onto changes in caste composition and practice in which an emphasis on conduct gave way in the early 20
kamal hassan’s character returns from london with hippie - style long hair but , after the death of his father , he gives up colored clothes , rids himself of his locks and sports a big moustache that marks him out as capable of filling his father’s shoes . critically , in the film , this responsibility should have gone to the elder brother , but his masculinity is at stake due to his alcoholism and lack of valor .
the soundtrack composed by a . r . rahman and all lyrics by vaali except
spiderman
song which was written by vairamuthu , was critically well received . in an interview in 2001 , surya earlier stated that deva had composed ten songs for the film , but he was later replaced by rahman . rahman remixed the 1964 hit tamil song
thottal poo malarum
from the movie
padagotti
with completely modified orchestration , tune and singers .
, spearheaded by periyar e . v . ramasami naicker and his “self - respect movement , ” in many ways had a direct influence in changing the structures of film making and inevitably led to the creation of a distinct tamil cinema that disrupted attempts to construct a sense of a nation through cinema ( leonard 2015 ) . these films departed from the earlier focus on religious and nationalist sentiments and articulated a rationalist critique of social ills . the founder of the
further undermining the anti - caste violence subtext of the film , the movie featured a provocative snippet in which the lead character virumandi is called “sandiyar” in one exchange and , when he corrects the character they reply : “you will always be sandiyar to us . ” there was also a song of the same name flying in the face of the compromise agreed to . the launch party was held in madurai as if to reinforce its 3m leanings , and prominently featured
6 sivappu malli ( red jasmine , rama narayanan , 1981 ) and kann sivanthaal mann sivakkum ( when eyes turn red , the soil too will , sreedhar rajan , 1983 ) are classics of this genre—dealing with labour unrest , feudal landlords and class disputes . the occasional film since that point has addressed similar themes , including aravindhan ( a name , t . nagarajan , 1997 ) and anbe sivam ( love is god , c . sundar , 2003 ) but these are few and far between .
( love , 2004 ) , for example , he sees a classic expression of the tamil psyche as constituted in tamil cinema ; one which is “torn between the threatening pre - modern assertion of caste and an allegedly ‘egalitarian , ’ free market space of modern individuals . ” in the film a dalit boy who “presumes” to court a thevar girl is grievously assaulted . taking our cue from krishnan’s work , it is possible to discern how such tropes are reproduced in a range of different films . thus , in
when the film begins , we see muthazhagu , an idealistic youth leader , who doesn ' t hesitate to take on aalavandan , a powerful minister in the state ( nasser ) . the father - son duo whose politics are at polar ends , however , live together . muthazhagu ' s mother and younger sister are his only solace . his older sisters are married to civil servants - - one is an ias officer and the other an ips officer . both civil servants are the real brain behind aalavandan ' s political designs .
sreenivasan’s “melodrama story period” was , of course , the period in which the dmk successfully mediated their socio - political message to the public through the medium of film . songs , story - lines , robin - hood style heroes and almost subliminal references to party symbols like the flag and the rising sun , were deployed to present the party as the champion of the downtrodden . some of the “excess dialogue” took the form of lengthy monologues in which the hero addressed the camera in lectures about socio - political values . as rajadurai and geetha ( 1996 : 572 ) note :
the moustache here becomes synonymous with tradition and social power and this knowledge is simultaneously deployed and reinforced in films . the close association between caste standing and facial hair is emphasized in one song where even background photographs of sivaji ganesan ( acclaimed tamil actor ) —who portrays the character of periya thevar—have been altered to sport an upturned moustache to be more in keeping with the thrust of the film . few men , as oldstone - moore ( 2011 ) argues , have groomed themselves in complete ignorance of the social implications and , we would add , still fewer directors shoot films in ignorance of the connotations that their character’s facial hair may have .
the film is all about a gripping relational emotions between a father and son who belong to same political party but with different ideas . alavandhar ( nasser ) is a double dealing education minister who wants to become chief minister and with the help of his son - in - laws sathya and ilamaran ( saran raj and ponvannan ) , he starts creating problems within the party to overthrow the rule of present chief minister ( vijay kumar ) . finally the government gets dissolved and alavandhan sets ready contesting for polls and it is at this point of time , his son mutthazhagan ( sarath kumar ) opposes his father and gets to become the home minister .
) , that archetypal symbol of traditional masculinity , caste pride , and feudalism which is most popular in madurai district . the backward and caste - bound nature of madurai in these films , is reinforced in accounts of the city’s frenetic fans who treat film stars as demigods ( dickey 1993 ) . it was in madurai that fans cut off fingers and limbs and offered them to god when mgr suffered a stroke , praying for his recovery . in his analysis of recent films , krishnan ( 2008 ) shows how madurai is now constructed in the narrative space of tamil cinema as the antithesis of the modern , and a place where people are still ruled by caste , clans , and kinship networks .
, however , the scene could be read as asserting that only a thevar can uphold the law . in any case , the symbolic submission to the state occurs at a time when thevars were being assiduously courted by both dravidian parties and gaining socio - political influence ( cf . human rights watch 1999 ) . we have dealt with this issue at some length because it has a critical bearing on the third facet of krishnan’s argument about self - fulfilling prophesies . here we would not just agree with his note of caution but argue that this has already happened to a great extent , as he himself notes by referencing the use of thevar film - songs at caste functions and events . the portrayal of a brigand - like , violent caste culture may well have been
what makes tamil cinema stand out , however , is its umbilical link to politics . cinema in the state grew hand in hand with the regional nationalist parties , helping to by - pass congress—who failed to realize the significance of the medium—in the process ( hardgrave 2008 : 61 ) . congressmen never realized the power of film , says kannadhasan , song - writer for the tamil screen and one of the founders of the dmk . “they decried the cinema . we used it . ” ( hardgrave 2008 : 61 ) . we would argue that tamil films since independence , may be divided into political as well as artistic genres . until the 1970s the dominant political message was dravidian . this overlapped somewhat with films showcasing a communist or socialist message between the late 1960s and mid - 1980s .
the script is a party manifesto for sarath . but it ' s a very peculiar one . this manifesto masquerading as a script is devoid of any political ideology . instead , it extols virtues like dignity , tolerance and generosity as is present in plenty in the hero muthazhagu ( played by sarath ) .
some of the sequences remind us of political events in the state . for example , the arrest of aalavandan reminds one of the arrest of chief minister m karunanidhi a few years ago .
sreekanth deva ' s music is ordinary . the background music is borrowed from a r rahman scores . the dialogue by ramesh kanna is condescending and overwritten . characters often talk more than they need to .
director suresh needs to realise that unless the scripts are original , it takes a miracle to save a movie . and even in a bankable star like sarath , he finds no miracle .
nothing to comment on the performance of sarath kumar for he seems to have done the same as he had done in his previous films . there is nothing special to comment on karthika’s performance for she has nothing to perform in the frame .
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has terrific title value , as it was mgr ' s launch pad when he formed his own political party after he fell out with the then chief minister and dmk supremeo m . karunanidhi , in the early 70 ' s . no wonder sarath kumar has kept the same title for his first release after the launch of his political party !
. the mallu original was a satirical look at a real life kerala minister who was corrupt and running politics and administration along with his i . a . s and i . p . s son ' s - in - law !
his son a ' mr . clean ' comes along exposes the corrupt family and later becomes a home minister who cleanses the system from within and becomes a mass hero . all this is told in light hearted manner with a dileep comic touch .
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a man not only alienates himself from his family but also endangers his life when he decides to stand for elections .
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aspiring to become the state ' s next chief minister , education minister aalavandhar conspires with his corrupt son - in - laws , ilamaran and sathya , to do away with the opposition and enable an uncontested election . he then decides to allocate land to a soft - drink company but faces opposition from his idealistic son , muthazhagu , who belongs to the youth wing of his own political party . the latter , with the help of the courts , is able to overturn the land allocation but ends up alienating his entire family against him . sathya and ilamaran then conspire against muthazhagu , and create challenges and obstacles for him in order to compel him to leave politics . when they find out that he is adamant and even willing to contest the elections against his father - they decide to do away with him - once and for all .
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deutschen herbst
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12 - year - old dre parker could have been the most popular kid in detroit , but his mother ' s latest career move has landed him in china . dre immediately falls for his classmate mei ying but the cultural differences make such a friendship impossible . even worse , dre ' s feelings make him an enemy of the class bully , cheng . with no friends in a strange land , dre has nowhere to turn but maintenance man mr . han , who is a kung fu master . as han teaches dre that kung fu is not about punches and parries , but maturity and calm , dre realizes that facing down the bullies will be the fight of his life .