extreme music/bleeding fingers is a production music company .

the production arm of sony/atv music publishing , the company creates and licenses music for use in television , film , advertising , and online media .

their library includes music from artists and composers such as quincy jones , hans zimmer , george martin , snoop dogg , xzibit , and junkie xl .

extreme music is headquartered in london , with its creative operations based in santa monica , california .

extreme music was founded in london in 1997 by russell emanuel and dolph taylor .

in 2013 extreme music partnered with composer hans zimmer and his business partner steve kofsky to found the joint-venture bleeding fingers custom music shop .

bleeding fingers focuses on creating show-specific libraries and scores for unscripted , reality , documentary and light drama television shows .

extreme music / bleeding fingers

a growing demand for custom music from extreme’s clients catalyzed the launch of bleeding fingers in august 2014 .
production companies extreme music / bleeding fingers and grooveaddicts for whom he has written music for media including news broadcast music , commercials and trailers across the usa and europe .
submission for hans zimmer / extreme music ' s bleeding fingers competition , incorporating zimmer ' s percussion stem and drawing from a modified version of his theme .
extreme music / bleeding fingers is a production music company . the production arm of sony / atv music publishing , the company creates and licenses music for use in television , film , advertising , and online media .
the technology allows customers to edit the music that they license from extreme music before the music airs in their production .
the grammy - and oscar - winning composer behind man of steel and dark knight is partnering with extreme music to launch the bleeding fingers custom music shop . at zimmer’s campus , the “stanford of score , ” they’ll craft tunes for duck dynasty , mountain men , and more .
representing one of the shop’s biggest coups , bleeding fingers beat out 13 bidding competitors , including three fellow music shops , to score the docu - series “planet earth ii . ” zimmer wrote the main theme and staff composers jacob shea and jasha klebe wrote the score proper , which was recorded by an 80 - piece orchestra — bleeding fingers’ biggest band to date — at london’s air studios .
you can read the full - report on sony / atv ' s extreme music and hans zimmer ' s joint venture the bleeding fingers custom music shop in tomorrow ' s billboard , which you can pick up at the billboard shop or subscribe now to billboard and read it online , in print and on your ipad .
extreme music , which is owned by sony / atv music publishing in new york , partnered with menlo park music technology company ujam to develop the software .
top producers timbaland and mike “daddy” evans have pacted with sony / atv music publishing’s extreme music to create 75 new urban pop tracks for the production music house .
“they’ve all been through the zimmer boot camp , ” says extreme music and bleeding fingers ceo russell emanuel ( kofsky will serve as the new company’s chairman ) . “these are seasoned tv and film composers . hans’s role is to bring in the talent . they’ll become bleeding fingers composers . our job is to bring in the business . ” bleeding fingers will compete with more democratic , digital , crowdsourced companies making music for reality tv . jingle punks , for example , a four - year - old music production company with offices in new york , l . a . , toronto , london , and sydney , has music on reality shows like pawn stars , american pickers , and the voice . the company is tech - driven and lets virtually anyone submit songs to be added to a catalog that’s polished and made available to music supervisors .
hans zimmer ( far left ) visits the studios of npr west with ( left to right ) contest winner daniel suett , bleeding fingers ceo russell emanuel and chairman steve kofsky . stephanie hall / courtesy of the artists hide caption
english / original title : the liberators – why we fought . writer : emanuel rotstein . camera : dirk heuer . sound : alexander towers , tino keck . editing : rodney sewell . music : bleeding fingers ( hans zimmer ) , extreme music . production : the history channel ( germany ) gmbh & co . kg . producer : emanuel rotstein . length : 60 min .
the custom - scoring business is long overdue for a major shake - up and we fully intend to bring it ,
said russell emanuel , the ceo of bleeding fingers and extreme music , in a prepared statement .
this is a natural evolution for us and represents major incremental growth and an exciting next chapter in our story .
very recently , imagem music group acquired 5 alarm music . in 2010 , warner chappell music , the global music - publishing arm of warner music group corp , acquired nashville’s 615 music , groove addicts production music library and london - based carlin recorded music library and in 2007 they acquired non - stop music . also in 2007 , universal music group , which already owned firstcom and mastersource , acquired killer tracks through its acquisition of bmg . in 2009 , sony atv music acquired extreme music .
emmanuel had launched extreme music just a year earlier in 1997 and was the talk of london after he mailed out condoms to a thousand music industry executives . the condom package read ,
extreme music : the only safe thing you ' ll get from us .
like extreme music , bleeding fingers ranks as the leading custom music scoring company in the industry . in addition to designing the soundtrack for hit shows like
$ 100 , 000 pyramid
, the duo notably won a highly competitive bid to orchestrate the original music for bbc america ' s standout series “planet earth ii” . in 2007 , planet earth reached an international audience of over 100 million people , going on to claim four emmy awards .
bleeding fingers custom music shop cut its ribbon three years ago , partnering with oscar winner hans zimmer to mass - produce scores for unscripted , reality , and documentary tv series that include “survivor” and “alaskan bush people . ” its latest and biggest catch is bbc’s upcoming “planet earth ii . ”
extreme music , which has a library of original music that it licenses for films , television shows , commercials and video games , announced wednesday the launch of its music editing tool , called customix .
extreme music ceo and bleeding fingers co - founder russell emmanuel ( photo courtesy of extreme music ) the market for production music has grown to an estimated valuation of $ 2 billion globally , ranging from television and film scoring , to electronic gaming and licensing for commercials . when this segment of the industry first emerged in the 1920′s and 30′s , very few companies existed in the space , and each followed a very basic business model . instead of utilizing talented musicians to create catalogs of original music , these niche production houses would simply replicate the top songs of th . . .
plans for the new venture include 18 new studios on zimmer’s sprawling santa monica , california , campus , a place they call the “stanford of score . ” clients of bleeding fingers won’t necessarily get hans zimmer himself in a room directing an orchestra . during his decades as a composer , he’s assembled a collective of understudies–musicians and composers to whom he’s delegated work . many have had direct hands in the work zimmer is most famous for . bleeding fingers offers these creators and other up - and - comers steady work .
“we set up extreme music to be the antithesis to what , at the time , was a production music industry that wasn’t very interesting , ” emanuel told forbes .
the winning composer , zimmer announced today on weekend edition sunday , is daniel suett , a 22 - year - old londoner fresh out of the leeds college of music . his reward — beyond enviable for a recent college graduate — is a job , working for bleeding fingers as a staff composer .
already , bleeding fingers ' client list includes it ' s always sunny in philadelphia , duck dynasty , boston ' s finest , the fox reboot of cosmos , judge judy , and more . the operation is run out of a new facility in santa monica .
according to emanuel , extreme music is the only production library that offers anything like customix , but that will not last long .
so nobody can accuse zimmer — an oscar - winner for disney ' s the lion king , and a three - time grammy - winner — of resting on his laurels . in fact , he ' s expanding the business in a joint venture launched earlier this year between extreme music and rci global , an investment company owned by zimmer and his business partner steve kofsky . the bleeding fingers custom music shop offers bespoke music libraries for television clients as well as custom scores for unscripted , reality , and
light drama
tv productions .
when zimmer ' s not supervising the bleeding fingers operation , he ' s continuing to write music for the big screen . you ' ll be able to hear his work soon in films including christopher nolan ' s interstellar , winter ' s tale , and the amazing spider - man 2 — among , we have no doubt , many others .
“there’s been a gap in the market for being able to do that , ” said russell emanuel , extreme music’s co - founder and chief executive .
extreme started as a small london - based music library . two decades later , the company maintains offices in three continents and 82 full - time employees . they quickly became the primary music source for power players like sony , paramount , disney , mtv , hbo , apple and american express . in 2012 , billboard named emanuel one of the 10 most powerful executives at sony / atv . moving extreme ' s headquarters to the states , the company is now anchored at a 7 , 500 square - foot production compound in santa monica , california . emanuel shares the world - class facility with oscar award - winning composer and longtime business partner hans zimmer , serving as the home to both extreme music and their joint venture bleeding fingers , which was founded in 2014 .
bleeding fingers custom music shop cut its ribbon three years ago , partnering with oscar winner hans zimmer to mass - produce scores for unscripted , reality , and documentary tv series that include “survivor” and “alaskan bush people . ” its latest and biggest catch is bbc’s upcoming “planet earth ii . ” the shop’s origins go back to 1982 , when russell emanuel [ … ]
extreme music has a catalog of just under 13 , 000 tracks that were created specifically for production soundtracks . that’s relatively small compared to the music libraries from giants such as universal music group , which has hundreds of thousands of songs available for license .
ryan demaree is a sundance award winning film & tv composer - as well as an established singer / songwriter . he has written for fox , warner bros , at & t , amazon , titmouse animation , big picture ranch , green planet , extreme music , bleeding fingers , and collaborated with several a list directors , composers , and artists in los angeles . he has performed and toured with national tours , choirs ( including the boston pops ) , country artists and rock bands .
the business that emmanuel built , however , is no laughing matter . while the company doesn ' t disclose its finances , emmanuel says extreme music is
very profitable .
viacom in august 2005 bought extreme for $ 45 . 1 million . three years later , sony / atv picked up extreme for an undisclosed sum . in both acquisitions , emmanuel remained in charge of the business .
emmanuel and remote control co - owner steve kofsky , who will be bleeding fingers’ chairman , are beginning to staff the operation by hiring a creative manager and an assistant with an eye to add two more . jacob shea , who has been in the remote control camp for almost six years , has been hired as the lead composer . the bleeding fingers studio is under construction next door to the homes of remote control and extreme in santa monica and once it is up to speed , emmanuel and kofsky figure it will have 16 composers working there . that figure owes to the building’s configuration of 14 writing rooms and two recording studios . bleeding fingers was created after extreme kicked the tires on a few production houses that offered scoring services . the impetus was requests from television production companies requesting custom tones and cues . ultimately , russell and kofsky say in different ways , bleeding fingers brings a unique level of seasoned composers , studio production and infrastructure to a business that , when it comes to music , is short on time and money . kofsky says it is as close to hiring a composer as a reality show might do . “but it’s done in an affordable way , ” he says , “ and they’re going to get more for their money” than using library tracks or hiring a single composer . “we have brands we want to protect . we know how to ( provide music ) effectively and efficiently , but maintain the integrity of both our brands . ” adds emmanuel , “essentially , it’s a lane of business that has been booming because of reality companies and it splits nicely between our two companies . both companies are trusted , diligent about copyright , and there’s a quality level . ”
songs from extreme music ' s library grace the soundtracks of works such as lincoln , mad men and dexter . kevin edelman , of metalman music , is the music supervisor for several shows , including homeland and criminal minds . he recently demoed a beta version of customix .
crimson tide , the lion king , inception , gladiator — that ' s just a handful of the many movies that feature award - winning scores by hans zimmer . lately , zimmer has lent his ear to soundtracks written by a new generation of aspiring film composers . he ' s been judging a contest for the bleeding fingers custom music shop , a production house in santa monica that makes music for reality tv shows — everything from duck dynasty to survivor .
extreme music , which employs 60 people worldwide , is expanding its santa monica operation by constructing a building next to its existing office that also will allow for more studio space .
entering the music library world , then , “seemed like a good way to get off the tour bus , ” so emanuel formed extreme music with a partner in 1997 — catering mostly fresh edm music to such clients as the bbc and itv . “top gear” was an early adopter .
a santa monica music company is hoping that an expansion into music technology hits the right note with customers .
that’s where zimmer and his new partners come in . if he can use music to help you understand what’s happening in inception , surely he can make reality tv better . the academy award - and grammy - winning composer behind the aforementioned film about dreams within dreams , plus the dark knight trilogy , man of steel , and about 100 more ( plus game call of duty : modern warfare 2 ) , along with his business partner steve kofsky , are teaming up with extreme music , sony / atv music publishing’s production music division , to officially launch the bleeding fingers custom music shop . they’ll target clients interested in custom - crafted music for light television drama , documentaries , and reality tv . in what they call a “proof of concept” period , they’ve already scored duck dynasty , boston’s finest , and the history channel’s mountain men , which won ascap and bmi awards .
bleeding fingers’ founders are targeting showrunners and music supervisors who are under the gun , budget - wise and deadline - wise , and don’t want to sift through a million crowdsourced tracks by no - name musicians using garageband . “it’s a quality play , ” zimmer says . “i don’t think anybody wants to make something of poor quality . the whole point is to encourage excellence . you gotta start somewhere . i think it’s important to try set an example . ”
this guest article was written by bob mair , ceo , owner and founder of black toast music , an independent music publisher / production music library based in chatsworth , ca .
“prior to extreme , there were businessmen creating catalogs , rather than creatives creating catalogs – so we were crowned the ‘bad boys’ of production music in our first year , and we owned it . ”
if you begin to notice more of those befitting songs in the coming months and years , a new web app released wednesday could be the reason why . extreme music , a popular music production library , just introduced a new feature called customix to its website .
music libraries were once the very last resort for music by supervisors and producers looking for music placements in their film and television projects . libraries were quite simply thought of as the bastard children of the music industry . today however , music libraries are quickly becoming more and more relevant by asserting themselves as legitimate competition to the record labels and major music publishers . the growing force of music libraries is evident in several areas , but nothing demonstrates this more dramatically than the fact that major music publishers have been scrambling to acquire the most prominent music libraries .
one of the powers of this application is that it turns you into a music editor without needing the deep music knowledge that a skilled music supervisor would need ,
emanuel said .
estimates of the size of the market for production music are nearly impossible to come by , making it difficult to calculate extreme ' s rank in the business .
when it comes to production value , compromise is for pussies ,
emmanuel says .
i pity the fool that ' s in competition with extreme . we are the bar .
••••
uk media music library extreme music has formed a joint - venture with media ventures entertainment group , the company headed by composer hans zimmer and producer jay rifkin . the venture , hothouse , will provide music production for composers , producers and film companies in both london and los angeles . hothouse also plans to launch a film composer agency service .
extreme music comes to the table with a catalog of about 13 , 000 unique copyrights , a fraction of what competing production music companies offer . emanuel says showrunners and supervisors don’t want to go shopping in a costco - sized store to try and find the perfect score . that’s why , he says , extreme has the “highest grossing music catalog in the world . ” “i know it’s cheesy and everything , but it really is about quality not quantity , ” emanuel says . “if you dive into these freight trains worth of music , it’s a small amount that’s making money . ”
bob wrote a well constructed and informative article about music libraries . being in the music clearance and cue sheet business for over 30 years , i love going to music libraries and have always known that bob mair and black toast music were top notch . you rock bob…and amy !
top producers timbaland and mike “daddy” evans have pacted with sony / atv music publishing’s extreme music to create 75 new urban pop tracks for the production music house . timbaland and evans — noted for their work with chart - toppers like jay - z , missy elliott , britney spears , katy perry and miley cyrus — join quincy jones , snoop dogg , hans [ … ]
founded in 1997 , extreme music boasts the number one production music catalog in the world . emanuel ' s trained team of world - class producers and musicians develop the entire music library in - house , creating and curating a catalog of tracks for their international roster of clients to use for placement in television shows , films , commercials , and other contemporary forms of media .
being an independent music songwriter and singer , i would love to place some contemporary pieces for television and movie production . music libraries appear to be a wonderful way to categorize different types of music , but with the similar concerns as music publishers . the cost diffential appears to be a very positive result of the music libraries although , with the end result being how i can place my music out there to be heard . black toast appears to be a significant force in the contemproary music industry .
seeing a prime opportunity to leverage their collective expertise to produce original scores for television and film , emanuel teamed up with hans zimmer to launch bleeding fingers . arguably the greatest film composer of all - time , zimmer has scored over 150 movies , including
the lion king
,
pirates of the caribbean
,
gladiator
,
the dark knight trilogy
and
the last samurai
. beyond winning an academy award , zimmer has also won four grammys and two golden globes .
levinson and emmanuel scratched out a budget on the back of a cigarette box , itemizing the things they ' d need to start their own company . in april 1997 , levinson wrote a check for â£100 , 000 and extreme music was born .
three ways to become the best at what you do so that your clients feel reassured by the price they pay you . russell emanuel was 15 years old when he decided to leave high school . he knew from a very young age that he was a musician , through and through . in 1997 he co - founded extreme music , a library stock of production music . extreme music became famous , not only for the music it offered , but also for the notorious punk energy and marketing that russell channeled through the brand . most memorably , he sent condoms to numerous industry professionals , printed with the message :
the only safe t . . .
“we get the music right before we get anything else right , ” said emanuel , who got his start in the music industry as punk rock musician .
read next : tencent music $ 30 billion ipo heads to u . s .
along with being able to provide high quality music at affordable prices , a network of indie artists , and a need to stay as current as possible ( to compete with the larger music publishing companies ) , music libraries can quickly create music with the hottest “new sound” before production companies even know they are looking for it .
timbaland and evans — noted for their work with chart - toppers like jay - z , missy elliott , britney spears , katy perry and miley cyrus — join quincy jones , snoop dogg , hans zimmer , paul oakenfold and mark mothersbaugh on the extreme roster . extreme prexy - ceo russell emanuel said , “our urban music offering is already second to none with snoop , quincy and rodney jerkins – adding these guys means we now have all the bases loaded . ”
his formula for recruiting world - class musicians and making high - quality recordings has earned extreme many top - tier clients in hollywood , including paramount , lionsgate , walt disney and fox , as well as major tv networks and brands like mtv , nbc , hbo , showtime , the bbc , american express , ford motor and the national football league . movies and tv shows that have used extreme ' s music include
katy perry : part of me ,
brave ,
snow white and the huntsman ,
csi ,
30 rock
and
jersey shore .
artists who have contributed music to extreme ' s catalog of 12 , 000 titles include hans zimmer , snoop lion , paul oakenfold , timbaland , james s . levine and george martin .
zimmer began contributing to extreme’s library in the late ’90s , and when the company spread to the u . s . in 2001 , it set up shop at his remote control productions campus in santa monica .
with film music , you ' re writing something that only suits the film , whereas tv music tends to follow trends of whatever music is kind of riding at the time ,
suett explained .
i was trying to see how many styles i could get out of one piece of music , and how different i could make each one .
from there , emmanuel moved on to bruton music , a library of production music now owned by universal publishing . at the time , production music had second - class status within the world of music publishing . the business was built around cheaply producing libraries of sound - alikes , songs that sound like famous tunes but without the large licensing fees of the originals .
i am the co - founder of a new music service called zamplify , that will be out this summer . our objective is to make it easier for the public and music industry leaders like you to find good music , by crowdsourcing the detection of the best new music and providing an effective way to assess the velocity of new artists ( by genre ) .
“when we went into this space , we totally underestimated the opportunity - - we certainly knew it was a big opportunity , but not as significant as big as what extreme ended up becoming , ” emanuel stated .
customix is only available to extreme music ' s subscribers , which means it ' s probably not for you unless you ' re an industry pro , or if you ' re independently producing high quality content for digital distribution . on the bright side , that means you can just kick back and relax , knowing that more felicitous music is on its way to the shows and movies you love to watch .
in other nat geo news today : the network announced that bill clinton will be the first guest on the new season of startalk , hosted by dr . neil degrasse tyson . season 2 premieres sunday , october 25 at 11 / 10 c . the two - hour special billy the kid : new evidence premieres sunday , october 18 , at 9 / 8c and globally on the national geographic channel . executive produced by kevin costner , the special traces the origins of a newly discovered tintype containing what appears to be a second image of the famed fugitive . nat geo wild has greenlighted big game of thrones ( wt ) , a wildlife miniseries that chronicles rival animal clans battling for supremacy in the wild . it premieres on nat geo wild globally in 2016 . and hans zimmer has signed on to score the main title theme music for national geographic channel’s upcoming movie event saints & strangers , shooting now in cape town , south africa . zimmer and extreme music’s bleeding fingers music will score the film . saints & strangers chronicles the trials and tribulations of the first settlers at plymouth . the four - hour film is slated to premiere on the network later this fall .
the online extension of billboard magazine , urltoken is the essential online destination for the music business .
the extreme music library limited was founded on 10 sep 1996 and has its registered office in london . the organisation ' s status is listed as
active
. it currently has 6 directors . the company ' s first directors were halliwells directors limited , hl secretaries limited . 20 - 49 people are employed at this company .
the park city film music festival is working to become a destination for film composers , aspiring artists and filmmakers . i am hoping that the music libraries will become sponsors and help us grow this industry .
customix works with many of the 13 , 000 songs in extreme music ' s library , which includes tracks from artists like hans zimmer , quincy jones , george martin and snoop lion . one doesn ' t need one of those producer ' s acumen to use customix , however — it was designed as an easy - to - use tool .
bob mair is the ceo , owner , and founder of black toast music , a leading , independent music publisher / production music library based in chatsworth , ca . since its launch in 1990 , the company has placed music in hundreds of television series , specials , promos , and tv movies , and dozens of high profile motion pictures , along with videogames , internet advertising campaigns , and numerous , multi - media presentations .
music libraries know that in order to compete , they must have music that will fit every possible use . libraries therefore create this music before it is even requested . when they do not have a certain type of music at hand , some libraries such as ours ( black toast music ) , will even create something specifically for the project . libraries know that their reputation for being able to deliver “anything and everything” that a project may need quickly and affordably is the only way to thrive in this competitive business . coupled with their strong attention to the needs of their clients , music libraries have continued to become even stronger and more of a force to be acknowledged .
indeed , in today’s economy , with budgets for placing music within entertainment properties more and more constrained , affordable high quality music is more important than ever before . this allows music supervisors , producers and creative directors seeking “cool” music to come to library companies and not have to spend an arm and a leg on a “famous” song . in such a scenario , everyone wins ; the indie artists get exposure and get paid , the library makes money , and the production company gets great music with less expense , and also acquires some “indie cred” in the process .
some great points here bob . i would add a fourth point to your list of why libraries add so much to a catalogue . certainly here at imagem production music , we create music that is built to work for synchronisation . so not only do we have a great existing range of music and a roster of brilliant composers , but we can guide them to writing music in a way that it works in exactly the way that our clients want . this is something that many commercial works lack – so in essence you’re getting cheaper music that works better to picture .
extreme currently adds just over 1 , 000 new tracks to its library each year , taking a very surgical approach to the music they produce . yet , despite a comparably low output , one key to extreme’s astonishing success has been continuously creating and diversifying their library . instead of adopting a limiting made - to - order business model , or mirroring popular trends , emanuel implements a perspective of entrusting great talent to freely create and collaborate .
what makes a production music library like ours so effective is that when a client selects a track , they know it ' s completely original and they can clear it ,
says emanuel .
one phone call , and it’s done - - often at a lower price point , because we offer a more efficient process .
extreme’s tracks have been used on network shows like “glee , ” “mad men , ” “30 rock , ” “entourage , ” “the office” and “gossip girl” ; and features and trailers including “the fighter , ” “avatar , ” “ twilight saga : eclipse ” and “inception . ”
fourteen years ago , emi production music chief peter cox summoned a punk rocker named russell emmanuel into his london office .
in the world of production music - with its dodgy history of sound - alike recordings - that was saying something .
extreme’s extensive catalog currently consists of over 15 , 000 original copyrights , covering the full spectrum of genres - - from classical and rage metal , to alternative rock and electronic dance music . the library even includes tracks from notable legends like quincy jones , snoop dogg and george martin . in 2008 , the company was sold to sony / atv for $ 110 million , with emanuel still remaining as the active ceo .
instead of scolding emmanuel , cox shook his hand and told him ,
you really are the bad boys of production music .
for zimmer , who previously partnered with extreme on customix , an online music library that edits music to video , this is a smart diversification in a rapidly changing time for major motion pictures in hollywood–the number of traditional big - budget projects are shrinking . “the world is shifting , ” zimmer says . “the way we tell stories is shifting . television writing has become so incredibly good , and at the same time you have reality shows , which have a completely different approach to telling stories . maybe not that different really from an robert altman movie if you think about it . ”
with the proliferation of affordable home recording equipment today , there are more and more unsigned bands than ever before . due to this rapid influx of unsigned artists , coupled with declining record sales , publishers and record companies are more overloaded than ever , and often do not have the time to sift through the mountains of music to find the gems nor do they have the resources to develop and market all of these talented new artists . there is therefore a plethora of extremely talented , yet unsigned and un - published , bands and music artists who are seeking to get their music “out there . ” these indie artists are now seeking out music libraries to help them market their music to film and television .
in 1996 , emmanuel decided to hang up his guitar and look for a
real job ,
as he calls it . he wound up at match music , a production music company in london that was sold a year later to bmg . once again unemployed , emmanuel talked to an acquaintance he ' d met while at match music , an angel investor named mark levinson . emmanuel pitched an idea for a production music company that would up the industry ante by using professional recording equipment and top - notch musicians that emmanuel had met in his decade of touring .
hugo has been commissioned by emi production music uk to compose and produce a film noir album to be recorded at abbey road studios in autumn 2018 .
mailing out condoms wasn ' t emmanuel ' s only hijinks in the early days . at an awards show put on by promax u . k . for tv marketing executives in 1999 , he bought a table front and center of the ballroom . he hired 10 people with dwarfism to attend , outfitting them in extreme music t - shirts emblazoned with the words
size isn ' t everything
on the back . emmanuel and his staff bought tickets for the back of the ballroom and watched the hilarity .
over time , as the media landscape began evolving , converging with the rapidly changing worlds of music and marketing , the need for disruption in the space arose . transitioning into the 1990 ' s , as paradigms started definitively shifting , two experienced musicians and industry veterans noticed the need for an easily licensable catalog of high quality original music . while sitting in a board room brainstorming ideas , russell emanuel birthed a concept that would eventually evolve to stand as the global leader in production music .
what i was really looking for ,
zimmer added ,
and what i didn ' t , of course , tell anybody , is : take that piece of music and ignore it as much as possible . fight with the music ; go and put your own stamp onto it . figure out how to be original .
the market for production music has grown to be worth an estimated $ 2 billion globally , ranging from television and film scoring , to electronic gaming and licensing for commercials .
just as artists are able to create high quality music due to affordable recording technology , so , too , can libraries . libraries which often have a vast network of songwriters , musicians and vocal artists at their disposal can quickly create high quality music at lower prices , thus allowing them to offer competitive licensing fees to diverse film and television projects .
a friend just sent me this article which i hadn’t previously seen . you pose the question and suggest answers to “what do these majors want and need from music libraries” . i think you’ve missed the main reason for the proliferation of production music library acquisitons by the “majors” in recent times . as i see it there are two main reasons . 1 ) it’s the 50 % retain on royalty splits ! also , the fact that more and more “performance” only deals are being offered to composers making this area of music publishing even more attractive to them . 2 ) by comparison to “core” catalog acquisition costs , generally production music libraries are cheap buys . bottom line – nothing more , nothing less !
“there was a real weariness to the old - school way libraries had been turning out copycat music , ” emanuel says . “we were actually committed not to doing that . ”
what i’m really interested to see in the future is how these libraries start indexing , cataloguing and archiving the wealth of music ( good & less good ) that they have .
libraries have been working steadily in this business for many years , but because of their status , they have had to work harder and faster , and usually under the radar . however , clearly today , this hard work is paying off . the fact that the major music publishers have recently acquired so many of the top music libraries demonstrates that libraries have something that the publishers cannot duplicate and therefore must buy . this reinforces the premise that music libraries have not only “arrived” but have today become “power players” within the entertainment , advertising and broadcasting industries .
the shop’s origins go back to 1982 , when russell emanuel was working in the mailroom of london music library bruton music . he was invited to record an album of sound - alike songs , corresponding to such bands as duran duran , and while he spent the next 15 years in the rock world , steady royalty checks from that first album “kept rolling in . ”
register today for billboard ' s 2013 film & tv music conference in los angeles oct . 29 - 30 at the w hollywood use promo code ' biz13 ' to get a special discount .
music can make or break a tv show , movie or even an advertisement . in entertainment media , a perfectly selected song will complement the visuals and dialogue , and enhance the overall impact .
over the past 20 years , we at black toast music have been fortunate to have had a good deal of success placing our music within tv shows , films and ad campaigns . our placements have included songs in multiple episodes of hbo’s “the wire , ” “true blood” and “treme , ” as well as fx’s “the shield , ” showtime’s “dexter” and many more . we are also proud to have our music play a part in almost every episode of the new show “glory daze , ” and we are also excited about our most recent commercial placement in the new national ad campaign for domino’s pizza .
great analysis , bob . it raised a question in my mind . you wrote that “publishers and record companies are more overloaded than ever , and often do not have the time to sift through the mountains of music to find the gems nor do they have the resources to develop and market all of these talented new artists” and that “indie artists are now seeking out music libraries to help them market their music to film and television . ” my question : aren’t libraries in the same boat as publishers and record companies when it comes to finding the gems among unsigned artists ? do you go differently about sifting through all the requests ?
* * and third , and possibly most importantly , in order to provide excellent service to their clients , libraries have created catalogs that cover almost every possible genre a music supervisor might need , making them a one stop shop .
hugo is a graduate of music production from kingston university london ( 2001 ) . he studied piano and composition privately and worked as in - house composer for music production company wise buddah in london . in 2007 he trained with ®emmy - award winning film composer hummie mann in seattle ( pacific northwest film scoring program ) and went on to work for ®emmy - award nominated film composer joey newman in los angeles , which laid his ground for scoring to picture .
greg , i’d be more than happy to discuss and answer any questions you may have in regard to your business model and how it relates to the music library business . i’d be curious to hear how your business model compares or differs from a company like taxi .
all of these acquisitions seem to indicate that these renowned libraries have something that the major publishers want and need . but the question remains– what could a music library possibly have that a company with a catalog as large and prestigious as , say warner / chappell , need ?
this trend to feature unknown “indie” acts in television programming actually began in the mid 90’s , with hit tv shows like “dawson’s creek” and “party of five . ” as a result of the exposure in these shows , many of these bands quickly crossed over into the mainstream . because of this phenomenon in the mid nineties , along with the decline of physical cd sales , indie bands are today more eager than ever to have their music featured in film and television . music libraries have become one of the easiest and most successful ways to get that to happen .
for example , if a music supervisor likes a song but wants to speed up the tempo to match a fast - paced scene , he could do that using customix . previously , he would have had to select a song that already had a tempo to match the scene in his movie .
hans zimmer went looking for the next great screen composer . hear the winning entry the mind behind the music of inception , gladiator and more says he was looking for someone who would take his prompt and
ignore it as much as possible .
he and the winner joined npr ' s rachel martin .
it ' s always been our duty to shake shit up , rip the industry a new one and create music so sexy you ' re going to need a safe word ,
emmanuel says .
if it ' s in our catalog , then it ' s 200 % legit , high - caliber audio ammo .
customix lets music supervisors quickly edit songs they plan to license . the app allows users to adjust the volume to individual elements of a track ( vocals , drums , guitar , bass , etc . ) , change a song ' s tempo without changing its pitch and edit the length of a song without cutting it into pieces .
anyone who goes to the movies know hans zimmer ' s work , even if they don ' t recognize his name right away . zimmer is the composer of the music for man of steel , the lone ranger , 12 years a slave , rush , last love , and the hit tv miniseries the bible . a nd that ' s just in 2013 .
our model is different from taxi . we are a social discovery engine that helps surface the best new music and artists , not a fee - based placement agent ( nothing wrong with that , and maybe those four words don’t do justice to taxi , but the point i’m trying to make is just that : our models are different . ) i can explain further when we talk .
sound and music do the emotional heavy lifting in unscripted shows like a & e’s quacky beardfest . they tell you how to feel , even when acting is sparse , expressions are hidden under camo caps and facial hair , and very little in the way of drama is actually transpiring before your eyes . even at their best , the visual components in reality tv involve a lot of dirty looks and slack - jaw glares .
for me , it ' s always been interesting to find new voices and develop new talent ,
zimmer told npr ' s rachel martin .
what interests me is just people being given a chance to write music , because the only way you can get better at it is if you write all the time . i think it ' ll prove a very good sort of training ground for everybody , and it gives purpose behind actually wanting to be a composer .
®la independent film award , ®nyc independent film award and ®european film award winner hugo de chaire is a british composer working in film and television . he has worked on films with directors including gilles paquet - brenner , paul kowalski and andrew martin , ®oscar - winning writer and producer julian fellowes , and worked for ®emmy - nominated composer joey newman . his music is regularly played by radio stations and tv networks around the world , among others classic fm uk , klassik radio germany and univision across the usa .
proudly , an unorthodox music powerhouse that pound for pound packs a punch that leaves the competition on the ropes begging for mercy . our unrivaled roster includes quincy jones , hans zimmer , sir george martin , snoop dogg , labrinth , rodney jerkins , robbie nevil , ramin djawadi , vince clarke , paul oakenfold , mark mothersbaugh , boris blank , timbaland , brian tyler , michael giacchino , james s . levine , xzibit , blues saraceno , john powell , harry gregson - williams , steve jablonsky , klaus badelt and junkie xl .
given a demo version , i was able to customize a track in under five minutes . after logging in , i first selected a type of music —
celtic punk .
then i picked a song called
craic addict
( craic is an irish term for fun ) . i entered that i wanted the song to be one minute in length , at which point the app smartly adjusted . then i muted the vocals , drums , electric guitars and lowered the volume on the bass . lastly , i dropped the tempo to 120 beats per minute .
today , however , emmanuel finds himself in the unlikely position of being one of the 10 most powerful executives at sony / atv , the world ' s largest music publisher . following its $ 2 . 1 billion acquisition of emi ' s publishing business in june , sony issued a list of the organization ' s executive hierarchy that included the 50 - year - old emmanuel . it also named other sony / atv heavyweights like joe puzio , peter brodsky , john pires , jody gerson , danny strick , jimmy asci and others who directly report to sony / atv chief martin bandier .
when this segment of the industry first emerged in the 1920 ' s and 30 ' s , very few companies existed in the space , and each followed a very basic business model . instead of utilizing talented musicians to create catalogs of original music , these niche production houses would simply replicate the top songs of the time , altering just enough of the sound to avoid getting sued . more notably , these production houses were run by traditional businessmen , instead of experienced musicians or skilled creative minds . thus , the industry was deprived of innovation , and eventually earned the reputation of being a low quality marketplace that was undoubtedly necessary , yet lacked intrigue .
among the hit tv shows to which black toast has provided music are : “true blood” ( hbo ) , “dexter” ( showtime ) , “treme” ( hbo ) , “the shield” ( fx ) , “the wire” ( hbo ) , “the life and times of tim” ( hbo ) , “csi” ( cbs ) , “america’s next top model” ( cw ) “prison break” ( fox ) , “sons of anarchy” ( fx ) , “modern family” ( abc ) “burn notice” ( usa ) , ”cold case” ( cbs ) , “everybody hates chris” ( cbs ) , “my name is earl” ( nbc ) , “nip / tuck” ( fx ) , “dark blue” ( tnt ) , “the young and the restless” ( cbs ) , “general hospital” ( abc ) , and “access hollywood” ( nbc ) .
they grew from a two - man operation to a dominant player in the market , with offices around the world and a library containing tracks by such notables as quincy jones , george martin , and snoop dogg for 15 , 000 original copyrights . emanuel — who sold the company to sony / atv for $ 110 million in 2008 , but remains ceo — is proud of that number .
“we’re very surgical about what we put in the catalog , ” he says . “our biggest competition , who we outperform , have a million copyrights . ”
“i’d like to see us doing a scripted drama . …that’s what we’d really love to do . ”
“it was an organic , natural fit , ” emanuel says of the launch .
the shop occupies a 7 , 500 - sq . - ft . building on zimmer’s campus , with 11 full - time composers on staff , many of them former zimmer apprentices .
“you get more bandwidth , ” he says . “our composers all collaborate with each other , all of them have a different strong point , and it’s getting the score to [ clients ] much quicker . ”


anacor pharmaceuticals is a biopharmaceutical company focused on discovering , developing and commercializing novel small-molecule therapeutics derived from its boron chemistry platform .

it is based in palo alto , california , united states .

anacor was founded in 2002 based on technology created by lucy shapiro at stanford university and stephen benkovic at pennsylvania state university .

cofounder david perry served as ceo and president from 2002 to 2014 , and took the company public in 2010 .

since then , the company has generated a pipeline of both topical and systemic boron-based compounds of which five are currently in clinical development .

in may 2016 , pfizer announced it would acquire anacor pharmaceuticals for $ 5.2 billion , expanding the company 's portfolio in both inflammation and immunology drugs areas .

anacor

anacor pharmaceuticals , inc . , palo alto , california , usa . lzane @ anacor . com .
r - release : anacor _ 1 . 1 - 3 . tgz , r - oldrel : anacor _ 1 . 1 - 3 . tgz
anacor pharmaceuticals , inc . ( nasdaq : anac ) - anacor pharmaceuticals to present phase 3 data of tavaborole for the topical treatment of toenail onychomycosis | benzinga
anacor is a biopharmaceutical company focused on discovering , developing and commercializing novel small - molecule therapeutics derived from its boron chemistry platform . anacor ' s first approved product , kerydin
pfizer to acquire anacor pharmaceuticals for $ 5 . 2 billion - the new york times
pfizer inc . is to pay $ 99 . 25 per anacor share . that ' s a 55 % premium over anacor ' s friday closing price of $ 64 . 03 .
sandoz launches kerdyn tm ( tavaborole ) topical solution , 5 % from anacor pharmaceuticals , inc .
a copy of the presentation will be available on anacor ' s website following the oral session .
score a big win for pfizer and its $ 4 . 5 billion buyout of anacor pharmaceuticals . the fda wednesday approved anacor ' s eczema treatment that is projected to be a $ 2 billion blockbuster .
the article anacor pharmaceuticals announces fda acceptance of tavaborole nda for filing originally appeared on fool . com .
the submission of the nda is a significant milestone for anacor ,
said david perry , anacor ' s chief executive officer .
anacor was founded eleven years ago based on the promise of boron chemistry . tavaborole is the first drug in our pipeline to reach this important milestone , and i ' d like to acknowledge and thank the entire anacor team for their hard work , dedication and persistence .
a big blow for anacor as its two patents got invalidated by ptab . anacor hold patent rights on its oxaborole antifungal drug tavaborole which got approved by fda in 2014 . ( kerydin solution 5 % ) .
sandoz launches kerdyn tm ( tavaborole ) topical solution , 5 % from anacor pharmaceuticals , inc . | sandoz
anacor have few or more patents claiming composition and approved indication . the snapshot of tavaborole ob has given below :
anacor pharmaceuticals , inc . clinical study of an2728 , a novel anti - inflammatory compound , shows efficacy in psoriasis
through a subsidiary , pfizer plans to launch a cash tender offer for all outstanding shares of anacor common stock for $ 99 . 25 per share in cash—55 % above anacor’s closing stock price of $ 64 . 03 on friday .
we appreciate david ' s commitment to anacor and the many contributions he has made over the past 12 years to help build anacor into the company it is today ,
board member paul klingenstein said in a press release .
anacor pharmaceuticals inc . president and ceo david perry has left the company as it awaits approval of its first drug .
pfizer ' s buyout of anacor pharmaceuticals for $ 5 . 2 billion is a bad move - - here ' s why
anacor ' s stock was up more than 55 % on monday morning , trading as high as $ 99 . 86 .
anacor pharmaceuticals , inc . clinical study of an2728 , a novel anti - inflammatory compound , shows efficacy in psoriasis | biospace
despite two solid successes together , today anacor is using naeja only for microbiology screening . anacor has expanded its internal chemistry group , and like many drug companies big and small these days , it has shifted most of its discovery chemistry outsourcing to asia .
perry had been in his roles with the anacor since 2002 , when he cofounded the company . he left the company tuesday .
anacor also expects to launch pivotal studies for another drug , an - 2728 , in patients with mild to moderate atopic dermatitis .
while complimentary to its product portfolio , pfizer ' s acquisition of anacor could take a long time to pay off for shareholders .
pfizer has completed its acquisition of silicon valley biotech group anacor securing access to its flagship non - steroidal topical pde4 inhibitor crisaborole .
pfizer is acquiring anacor pharmaceuticals . the deal is expected to close in the third quarter . ( mark lennihan / associated press )
in july 2014 , sandoz announced an agreement with anacor pharmaceuticals , inc . to obtain exclusive rights to commercialize kerydintm in the us .
contact : david perry , chief executive officer of anacor pharmaceuticals , + 1 - 650 - 739 - 0700 ; or brian reid of weisscomm partners , inc . , + 1 - 703 - 402 - 3626 , breid @ weisscommpartners . com , for anacor pharmaceuticalsinc .
“anacor was founded eleven years ago based on the promise of boron chemistry . tavaborole is the first drug in our pipeline to reach this important milestone , and i ' d like to acknowledge and thank the entire anacor team for their hard work , dedication and persistence . ”
the fda has approved eucrisa , an eczema treatment developed by anacor pharmaceuticals , which pfizer bought for $ 4 . 5 billion in june .
under the terms of the agreement , a subsidiary of pfizer will acquire anacor for $ 99 . 25 a share in cash . that represents a 55 percent premium over anacor’s closing stock price from friday . pfizer plans to finance the transaction through existing cash on its balance sheet .
the investments from gsk and schering corporation fulfill each company ' s investment obligations pursuant to their respective and ongoing collaborations with anacor . at the conclusion of the financing , the combined ownership of gsk and schering corporation will be less than 20 percent of anacor ' s outstanding shares .
anacor pharmaceuticals is a biopharmaceutical company developing novel small - molecule therapeutics derived from its boron chemistry platform to treat infectious and inflammatory diseases . anacor’s most advanced product candidate is an2690 , a novel topical antifungal for the treatment of toenail onychomycosis , a fungal infection of the nail and nail bed . anacor also has a portfolio of other topical product candidates in development for the treatment of psoriasis , atopic dermatitis and skin and nail fungal infections .
pfizer inc . ( nyse : pfe ) and anacor pharmaceuticals , inc . ( nasdaq : anac ) today announced that they have entered into a definitive merger agreement under which pfizer will acquire anacor for $ 99 . 25 per anacor share , in cash , for a total transaction value , net of cash , of approximately $ 5 . 2 billion , which assumes the conversion of anacor’s outstanding convertible notes . the boards of directors of both companies have unanimously approved the transaction . anacor’s flagship asset , crisaborole , a differentiated non - steroidal topical pde4 inhibitor with anti - inflammatory properties , is currently under review by the u . s . fda for the treatment of mild - to - moderate atopic dermatitis , commonly referred to as eczema .
pfizer ' s buyout of anacor pharmaceuticals for $ 5 . 2 billion is a bad move - - here ' s why - - the motley fool
anacor also holds the rights to kerydin , a topical treatment for onychomycosis ( toenail fungus ) that is distributed and commercialised by sandoz in the us .
anacor ' s topical treatment for eczema , called crisaborole , is under review by the food and drug administration . if approved , pfizer said it believes peak year sales could reach or exceed $ 2 billion . anacor , based in palo alto , also holds the rights to a topical treatment for toenail fungus called kerydin .
anacor’s drugs would fit with the innovative business , said albert bourla , group president of pfizer’s global innovative pharma and global vaccines , oncology and consumer health care businesses .
anacor pharmaceuticals today announced that it has raised $ 50 million through a preferred stock financing with participation from glaxosmithkline , schering corporation and existing investors including rho capital partners , venrock associates , care capital and aberdare ventures . proceeds from the financing will be used to further develop anacor ' s product pipeline based on its boron chemistry platform .
this press release contains forward - looking statements , including statements regarding the progress , timing and results of anacor ' s clinical trials , safety and efficacy of anacor ' s product candidates , timing and potential approval of anacor ' s product candidates and timing and potential commercial success of anacor ' s products . these statements constitute forward - looking statements within the meaning of section 27a of the securities act of 1933 and section 21e of the securities exchange act of 1934 . the words
may ,
might ,
will ,
should ,
estimate ,
project ,
plan ,
anticipate ,
expect ,
intend ,
outlook ,
believe
and other similar expressions are intended to identify forward looking statements . readers are cautioned not to place undue reliance on these forward - looking statements , which speak only as of the date of this release and anacor undertakes no obligation to update any forward - looking statement in this press release except as required by law . these forward - looking statements are based on estimates and assumptions by anacor ' s management that , although believed to be reasonable , are inherently uncertain and subject to a number of risks and uncertainties . the following represent some , but not necessarily all , of the factors that could cause actual results to differ from historical results or those anticipated or predicted by anacor ' s forward - looking statements : anacor ' s ability to timely and successfully launch , either alone or with a partner , kerydin ; any issues or delays arising during the course of anacor ' s phase 3 studies or other clinical trials relating to an2728 ; any delay or failure by the fda to approve an2728 ; anacor ' s ability to timely and successfully launch , either alone or with a partner , an2728 ; and the other risks identified in anacor ' s periodic filings , including anacor ' s quarterly report on form 10 - q for the quarter ended march 31 , 2014 .
hernandez has no complaints about his asian partners . still , he does look back fondly on anacor’s chemistry collaboration with naeja , recalling the quality of its scientists , their excellent communication skills , and the closeness of the interaction between the two firms . “we treated the chemists on the program like they were anacor chemists , ” he says .
anacor also holds the rights to kerydin , a topical treatment for onychomycosis ( toenail fungus ) that is distributed and commercialized by sandoz inc . in the u . s .
pfizer inc . is acquiring anacor pharmaceuticals inc . , a california company with a potentially lucrative eczema treatment , in a deal valued at about $ 5 . 2 billion .
anacor pharmaceuticals is out to change that . the palo alto , calif . - based biotechnology company is developing a family of boron - containing small - molecule drugs . and with the assistance of naeja pharmaceutical , a canadian contract research organization , anacor has licensed one of those molecules to glaxosmithkline and taken another one into phase iii clinical trials .
“today marks the beginning of an exciting new chapter for anacor , which we believe will deliver significant value to our shareholders , ” said paul l . berns , anacor’s chairman and chief executive officer . “we have a deep respect for pfizer , and it is clear that they share our commitment to addressing the significant unmet medical needs in inflammatory disease . we are proud of the innovative company that our team has built and are confident that pfizer will help accelerate anacor’s important mission given the strength of its global platform and resources . ”
pfizer will acquire anacor pharmaceuticals for $ 5 . 2 billion , the companies announced monday . anacor has developed a product , currently under review by the food and drug administration , known as crisaborole , to treat eczema . the company , based in palo alto , calif . , also makes a topical treatment called kerydin for a form of toenail fungus .
anacor could eventually be a decent buy . pfizer reckons annual sales of the target’s crisaborole eczema gel may hit $ 2 billion or more . that would put anacor’s value at $ 9 billion , using pfizer’s multiple of 4 . 5 times sales . pfizer is also expected to make a handsome profit from kerydin , which attacks fungus that can grow under toenails .
the closing of the tender offer is subject to customary closing conditions , including u . s . antitrust clearance and the tender of a majority of outstanding anacor shares . under the merger agreement , pfizer will acquire any shares of anacor that are not tendered into the offer through a second - step merger to be completed promptly after the close of the tender offer .
anacor anticipates that it will complete its review of this phase 2a trial for an2728 and an2898 for the treatment of atopic dermatitis in early 2012 . following this review , anacor plans to communicate the next steps in the development plans for one or both of these drug candidates in atopic dermatitis . anacor does not anticipate that costs related to development in atopic dermatitis in 2012 will materially affect the company’s previously stated ability to complete its two phase 3 trials for tavaborole in onychomycosis and its first phase 3 trial for an2728 in psoriasis with its current financial resources .
christopher micetich , now president of naeja , recalls that his scientists tackled the anacor job with gusto . company chemists helped discover the benzoxaborole scaffold , which led to the discovery of an2690 , an antifungal now being developed to treat onychomycosis , an infection of the toenail . in 2005 , an2690 became the first of anacor’s five boron - containing compounds to enter clinical trials .
given the collaboration’s success with the first scaffold , it’s no surprise that anacor hired naeja again a few years later . by then hernandez was on board , and he and his colleagues were trying to figure out what made an2690 work . anacor’s discovery biology group , led by dickon alley , identified the compound’s target , an enzyme called leucyl - trna synthetase , or leurs . then , working with stephen cusack at the european molecular biology laboratory in grenoble , france , anacor scientists solved the cocrystal structure of an2690 bound to leurs from either bacteria or fungi .
pfizer has agreed to acquire anacor pharmaceuticals for approximately $ 5 . 2 billion , the companies said today , in a deal that would expand the buyer’s portfolio of inflammation and immunology drugs .
pfizer’s acquisition of anacor would include its flagship asset crisaborole , a differentiated nonsteroidal topical pde4 inhibitor whose nda is under review by the fda . crisaborole is indicated for mild - to - moderate exczema .
centerview partners and guggenheim securities provided financial advice to pfizer , while wachtell , lipton , rosen & katz provided legal advice . anacor was advised by citigroup and the law firm davis polk & wardwell .
given the safety profile exhibited by an2728 in 13 clinical studies , the positive outcome from the atopic dermatitis trial , and the large unmet medical need in atopic dermatitis relative to psoriasis , anacor intends to focus its an2728 development activities on atopic dermatitis in 2012 and will defer the start of the phase 3 trial in psoriasis . anacor will provide more specific information on these activities in a future communication .
pfizer’s $ 5 . 2 billion offer for anacor pharmaceuticals , announced on monday , dodges the drug giant’s bigger issue . the company may have made a good deal for anacor , the maker of eczema and toenail - fungus remedies , even though it’s paying a 55 percent premium . the more important question for shareholders , though , is whether pfizer’s chief executive , ian c . read , will break up pfizer .
tavaborole was patented as a product in us 5 , 880 , 188 a which had expired . the drug was later licensed to anacor , which initiated the trails and succeded to bring the drug into the market .
anacor is a biopharmaceutical company developing novel small molecule therapeutics derived from its boron chemistry platform . anacor has focused initially on developing topical applications of its compounds to treat fungal , bacterial and inflammatory diseases . in addition , the company is developing systemic antiviral and antibacterial therapeutics under a research and development agreement with glaxosmithkline . anacor ' s most advanced product candidate is an2690 , a novel topical antifungal in development for the treatment of toenail onychomycosis , which is a fungal infection of the nail and nail bed . an2690 is licensed to schering - plough corporation under a worldwide development and commercialization agreement for all indications including the treatment of onychomycosis . for more information visit
under the terms of the merger agreement , a subsidiary of pfizer will commence a cash tender offer to purchase all of the outstanding shares of anacor common stock for $ 99 . 25 per share in cash . the closing of the tender offer is subject to customary closing conditions , including u . s . antitrust clearance and the tender of a majority of the outstanding shares of anacor common stock . the merger agreement contemplates that pfizer will acquire any shares of anacor that are not tendered into the offer through a second - step merger , which will be completed promptly following the closing of the tender offer . pfizer expects to complete the acquisition in the third - quarter 2016 .
pfizer closed its buyout of anacor in june , a bite - sized deal it knocked off shortly after it halted its planned buyout of allergan . the company abandoned that plan after tax rule changes made them it less appealing .
the us drugs giant announced earlier this year that it would purchase all of the outstanding shares of anacor common stock for $ 99 . 25 per share , equating to a deal value of around $ 5 . 2 billion .
now that anacor is part of pfizer , we can accelerate our shared commitment to help patients with inflammatory disease , an area of high unmet medical need ,
said albert bourla , group president , pfizer innovative health .
kerydin was designed to be convenient for patients to use and has demonstrated efficacy in the treatment of the fungal infection , thus allowing growth of new uninfected nail ,
said vince ippolito , chief commercial officer of anacor pharmaceuticals .
in market research conducted by anacor , kerydin ' s product profile was received with great enthusiasm by the participating physicians and we believe this response demonstrates the need for a safe topical treatment for onychomycosis of the toenails .
pfizer ' s buyout of anacor pharmaceuticals for $ 5 . 2 billion is a bad move - - here ' s why @ themotleyfool # stocks $ pfe , $ anac . dl , $ sny , $ celg , $ regn
the information contained in this release is as of may 16 , 2016 . neither pfizer nor anacor assumes any obligation to update forward - looking statements contained in this release as the result of new information or future events or developments .
princeton , new jersey , september 22 , 2014 - sandoz , through its branded dermatology business , pharmaderm , today announced the us launch of kerydintm ( tavaborole ) topical solution , 5 % , developed by anacor pharmaceuticals , inc .
footnotes : 1 for full safety information , please see the kerydintm ( tavaborole ) topical solution , 5 % , prescribing information , available in the product catalog at urltoken . 2 kerydin is a trademark of anacor pharmaceuticals , inc .
pfizer said today it believes anacor’s crisaborole could rack up peak - year sales of $ 2 billion or more . the pharma giant cited positive results from two phase iii studies showing crisaborole achieving statistically significant results on all primary and secondary endpoints .
while i ' m all for having pfizer use its cash flow to boost the inorganic growth side of the equation , i ' d contend that it vastly overpaid for anacor when it offered $ 5 . 2 billion for the drug developer .
( tavaborole ) topical solution , 5 % , is an oxaborole antifungal approved by the u . s . food and drug administration in july 2014 for the topical treatment of onychomycosis of the toenails . in july 2014 , anacor entered into an exclusive agreement with sandoz inc . , a novartis company , pursuant to which pharmaderm , the branded dermatology division of sandoz , distributes and commercializes kerydin in the united states . in september 2014 , pharmaderm launched kerydin . anacor ' s lead product development candidate is crisaborole topical ointment , 2 % , a novel non - steroidal topical anti - inflammatory pde - 4 inhibitor in development for the potential treatment of mild - to - moderate atopic dermatitis and psoriasis . beyond kerydin and crisaborole , anacor has discovered three investigational compounds that it has out - licensed for further development . anacor also has a pipeline of other internally discovered topical and systemic boron - based compounds in early stages of research and development . for more information , visit
we are pleased to complete this financing , which will allow us to advance our five clinical programs and to identify and progress new compounds derived from our boron chemistry platform ,
said david perry , chief executive officer at anacor pharmaceuticals .
there are some major caveats , of course . anacor has not yet won approval for crisaborole from the food and drug administration . a decision is due by january . and pfizer’s estimates might not account for competing drugs and gels coming to market .
these trial results demonstrate that an2728 has the potential to make an important contribution to the treatment of psoriasis ,
said karl beutner , m . d . , ph . d . , and chair of anacor ' s clinical advisory board .
pfizer’s financial advisors for the transaction were centerview partners and guggenheim securities , and wachtell , lipton , rosen & katz acted as its legal advisor . citi served as anacor’s financial advisor , and davis polk & wardwell , llp served as its legal advisor .
anacor requested a special protocol assessment ( spa ) from the u . s . food and drug administration ( fda ) for the phase 3 trial design of an2728 in psoriasis and has reached concurrence on the major parameters of the phase 3 trial design .
we believe that pfizer is in a position to quickly capitalise on the benefits offered by the combination with anacor , including the potential for a near - term us product launch and subsequent commercialisation of crisaborole , a differentiated asset with compelling clinical data
.
anacor pharmaceuticals ( nasdaq : anac ) announced today that the first patient has been dosed in a phase 2 trial of an2728 and an2898 to determine safety , tolerability and efficacy of the two compounds for the topical treatment of mild - to - moderate atopic dermatitis .
this press release contains forward - looking statements with respect to the fda goal date for anacor ' s product candidate , tavaborole . these forward looking statements involve known and unknown risks , uncertainties and other factors that could cause actual levels of activity , performance or achievement to differ materially from those expressed or implied by these forward - looking statements , including risks related to the regulatory approval process of new drug candidates . reference should be made to anacor ' s annual report on form 10 - k for the year ended december 31 , 2012 , filed with the securities and exchange commission under the heading
risk factors
and anacor ' s subsequent quarterly reports on form 10 - q for a more detailed description of such factors . these statements reflect the views of anacor as of the date of this press release with respect to future events and , except as required by law , it undertakes no obligation to update or revise publicly any forward - looking statements , whether as a result of new information , future events or otherwise after the date of this press release .
anacor brought in naeja to optimize abx . once again , micetich says , naeja’s medicinal chemists did the job , helping discover a new molecule , an3365 , with the aid of x - ray crystallography and computer modeling . naeja also contributed to process chemistry . the chemists followed their original “medchem” synthesis , which used chiral high - performance liquid chromatography , with a gram - scale synthesis based on diastereomeric salt resolution . according to hernandez , anacor later transferred the naeja process to contract manufacturer regis technologies for phase i clinical trial production with only minor modifications .
since anacor pharmaceuticals was founded , they launched one dru g and are currently in the process of approval for another product . in july 2014 , the u . s . food and drug administration approved kerydin® ( tavaborole ) topical solution , an oxaborole antifungal , for the topical treatment of onychomycosis of the toenails . in a july 13 press release , anacor announced that crisaborole topical ointment , non - steroidal topical anti - inflammatory treatment , had positive top - line results from two phase 3 pivotal studies . in a recent press release , chairman and chief executive officer of anacor paul l . berns said , “we currently plan to file a new drug application for crisaborole in the first half of 2016 and , if approved , we believe crisaborole could offer an important treatment option for patients with mild - to - moderate atopic dermatitis . ”
anacor is a biopharmaceutical company focused on discovering , developing and commercializing novel small - molecule therapeutics derived from its boron chemistry platform . anacor has discovered six compounds that are currently in development including its lead compounds : tavaborole , a topical antifungal for the treatment of onychomycosis ; an2728 and an2898 , topical anti - inflammatory pde - 4 inhibitors for the treatment of psoriasis and atopic dermatitis ; gsk ‘052 ( formerly referred to as an3365 ) , a systemic antibiotic for the treatment of infections caused by gram - negative bacteria , which has been licensed to glaxosmithkline under the companies ' research and development agreement ; and an8194 which has been licensed to eli lilly and company for an undisclosed animal health application . anacor is also developing an2718 as a topical antifungal product candidate for the treatment of onychomycosis and skin fungal infections . for more information , visit urltoken .
“anacor is interested in keeping that boron in the final compound , ” says vincent hernandez , who joined anacor in 2005 as a bench scientist and is now the firm’s director of medicinal chemistry . boron generally forms three bonds to pair up the three electrons in its outer shell . but boron also has an empty p orbital that can form a fourth bond , known as a dative or coordinate covalent bond . when interacting with targets , such bonds offer greater stability than the noncovalent interactions of most pharmaceuticals . they are particularly useful in enzyme inhibition , hernandez says .
anacor was founded in 2002 to develop technology created by lucy shapiro , a stanford university bacterial geneticist , and stephen j . benkovic , a pennsylvania state university organic chemist . through a long - standing scientific collaboration , the two researchers had discovered boron - containing compounds that inhibited specific bacterial targets .
anacor released positive top - line phase iii data for the most advanced of its boron - based anti - infectives , the antifungal tavaborole , but the results weren’t good enough for some shareholders who were looking for the compound to best valeant’s antifungal , currently pending at fda with a may action date .
for the hefty sum of $ 99 . 25 in cash per share , or a 55 % premium to where anacor shares closed on friday . the crown jewel of the $ 5 . 2 billion acquisition is crisaborole , a non - steroidal topical anti - inflammatory pde - 4 inhibitor that ' s been submitted for regulatory review in the u . s . for mild - to - moderate atopic dermatitis ( a type of eczema ) . crisaborole is also being studied as a treatment for psoriasis . pfizer believes that anacor ' s lead compound could generate up to $ 2 billion in peak annual sales .
as for an2690 , anacor launched phase iii clinical trials in december 2010 . the company had licensed the compound to schering - plough in 2007 , in exchange for a $ 40 million payment , but merck & co . returned commercialization rights in early 2010 , some six months after acquiring schering - plough .
with this new treatment and others being explored , anacor researchers have the potential to make an impact in their core therapeutic areas of fungal , inflammatory , and bacterial diseases . their research could also potentially have applications in non - core areas , such as parasitic , cancer , and ophthalmic indications and animal health .
anacor is a biopharmaceutical company focused on discovering , developing and commercializing novel small - molecule therapeutics derived from its boron chemistry platform . anacor has discovered eight compounds that are currently in development . its two lead product candidates are topically administered dermatologic compounds — tavaborole , a topical antifungal for the treatment of onychomycosis , and an2728 , a topical anti - inflammatory pde - 4 inhibitor for the treatment of atopic dermatitis and psoriasis . in addition to its two lead programs , anacor has discovered three other wholly - owned clinical product candidates — an2718 and an2898 , which are backup compounds to tavaborole and an2728 , respectively , and an3365 an antibiotic for the treatment of infections caused by gram - negative bacteria . we have discovered three other compounds that we have out - licensed for further development — two compounds for the treatment of animal health indications that are licensed to eli lilly and company and an5568 , also referred to as scyx - 7158 , for human african trypanosomiasis ( hat , or sleeping sickness ) , which is licensed to drugs for neglected diseases initiative , or dndi . we also have a pipeline of other internally discovered topical and systemic boron - based compounds in development . for more information , visit http : / / www . anacor . com .
anacor is a biopharmaceutical company focused on discovering , developing and commercializing novel small - molecule therapeutics derived from its boron chemistry platform . anacor has discovered six compounds that are currently in development including its three lead programs : tavaborole , a topical antifungal for the treatment of onychomycosis ; an2728 , a topical anti - inflammatory pde - 4 inhibitor for the treatment of psoriasis and atopic dermatitis ; and gsk 2251052 , or gsk ‘052 ( formerly referred to as an3365 ) , a systemic antibiotic for the treatment of infections caused by gram - negative bacteria , which has been licensed to glaxosmithkline under the companies ' research and development agreement . anacor is also developing an2718 as a topical antifungal product candidate for the treatment of onychomycosis and skin fungal infections and an2898 as a topical anti - inflammatory product candidate for the treatment of psoriasis and atopic dermatitis . in addition , an8194 has been licensed by eli lilly and company and is in development for an animal health application . for more information , visit urltoken .
anacor’s flagship asset , crisaborole , has a new drug application under review by the u . s . food and drug administration ( fda ) , is a differentiated non - steroidal topical pde4 inhibitor with compelling clinical data , and if approved , has the potential to be an important first - line treatment option for patients with atopic dermatitis
kerydin is , to be blunt , an afterthought in this acquisition . anacor forged an agreement with sandoz to help market kerydin back in 2014 , and last year total distribution and commercialization segment revenue was $ 69 . 7 million . with peak sales estimates of $ 400 million , it ' s not going to move the needle much for pfizer .
anacor , meanwhile , already had an approved drug in kerydin , an anti - fungal drug that is marketed in the u . s . by novartis’ generics unit sandoz . the big draw for pfizer , however , was the non - steroidal topical gel crisaborole , which pfizer has said would be the first new eczema treatment approved in 15 years .
anacor’s work - around was a family of cyclic boronic esters known as benzoxaboroles . the firm discovered the esters about eight years ago under a $ 22 million department of defense contract to explore the use of boron chemistry against biowarfare agents such as anthrax . because of their cyclic element , benzoxaboroles have improved solubility and better metabolic stability , hernandez says .
it was hernandez himself who discovered the breakthrough an2690 derivative , known as abx . subsequent preclinical results formed the basis of the gsk collaboration . in october 2007 , the pair signed a boron - based anti - infective medicines deal worth $ 12 million up front to anacor and as much as $ 331 million in milestone payments for each product candidate .
“we believe the acquisition of anacor represents an attractive opportunity to address a significant unmet medical need for a large patient population with mild - to - moderate atopic dermatitis , which currently has few safe topical treatments available , ” albert bourla , group president of pfizer’s global innovative pharma and global vaccines , oncology and consumer healthcare businesses , said in a statement .
anacor announced earlier this year that tavaborole achieved statistically significant and clinically meaningful results on all primary and secondary endpoints in two phase 3 pivotal studies of tavaborole to treat onychomycosis topically without concomitant debridement . the only currently fda - approved topical treatment for onychomycosis is approved with concomitant nail debridement , and currently approved oral therapies have been associated with rare but serious safety issues .
if you follow the stock market , you’ve surely taken note of the continually climbing value of anac stock ( anacor pharmaceuticals , a biopharmaceutical company based in palo alto , california ) . the company , founded in 2002 , was created around boron chemistry technology developed by dr . stephen benkovic of penn state university and co - founder dr . lucy shapiro of stanford university .
this press release may contain forward - looking statements that relate to future events including the timing for filing of a new drug application , or nda , related to tavaborole and the potential fda approval of tavaborole . these forward looking statements involve known and unknown risks , uncertainties and other factors that could cause actual levels of activity , performance or achievement to differ materially from those expressed or implied by these forward - looking statements , including risks related to regulatory approval of new drug candidates . reference should be made to anacor ' s annual report on form 10 - k for the year ended december 31 , 2012 , filed with the securities and exchange commission under the heading
risk factors
and anacor ' s subsequent quarterly reports on form 10 - q for a more detailed description of such factors . these statements reflect the views of anacor as of the date of this press release with respect to future events and , except as required by law , it undertakes no obligation to update or revise publicly any forward - looking statements , whether as a result of new information , future events or otherwise after the date of this press release .
anacor pharmaceuticals ( nasdaq : anac ) announced today that on july 26 , 2013 it submitted its new drug application ( nda ) to the u . s . food and drug administration ( fda ) for tavaborole , its drug candidate for the topical treatment of onychomycosis . onychomycosis is a fungal infection of the nail and nail bed that affects approximately 35 million people in the united states .
“we are pleased to present these positive data at the apma ' s annual scientific meeting , the leading annual meeting of podiatrists . as we seek fda approval for tavaborole , we look forward to developing relationships with podiatrists to potentially offer them a new treatment option for the large number of patients who seek treatment for onychomycosis , ” said david perry , chief executive officer of anacor pharmaceuticals .
although velcade has nothing to do with anacor or gsk , perry interprets its approval and growing use as the final proof that boron itself poses no fundamental risk to humans ; safety will be determined by the design of individual drugs , just as has been the case with traditional carbon - based compounds . meanwhile , anacor hopes to make its commercial debut with a boron - based drug called an2690 ® , which they hope to use to treat onychomycosis , a fungal infection that affects fingers and toes , causing the nail to become brittle and discoloured with soreness of the surrounding skin . although rarely serious , onychomycosis can cause pain and accounts for half of all nail abnormalities , so any treatment has considerable market potential ; phase iii clinical trials are scheduled to begin early in 2009 .
the good news here is pfizer is generating more than enough cash flow to facilitate additional deals , and its oncology segment is on fire with an immuno - oncology offering ( avelumab ) waiting on the wings . the bad news is i don ' t believe its acquisition of anacor was a particularly good move , and i don ' t see any immediate benefits to this deal for shareholders .
an2690 is a potent antifungal that doesn’t inhibit bacteria , and the crystal structure showed that this was because the compound wasn’t reaching a key binding site on bacterial leurs . analogs of an2690 that bound there as well , the anacor team reasoned , would have the potential to inhibit bacteria instead of fungi . “that was the beginning of a structure - based drug design program , ” hernandez says .
palo alto , calif . , june 6 / prnewswire / - - anacor pharmaceuticals , a privately held pharmaceutical company , announced today the results from its placebo - controlled phase 1 trial of an2728 , a first - in - class topical therapy under investigation for the treatment of psoriasis . the trial showed an2728 to be well - tolerated , with activity comparable to existing topical treatments for psoriasis .
the timing of perry ' s departure is odd , considering that anacor is ramping up for potential food and drug administration approval by the end of july of the nail fungus treatment kerydin . the company earlier this month hired vince ippolito as executive vice president and chief commercial officer , noting his experience in launching new products , and perry last week led the company ' s quarterly call with analysts .
anacor is a biopharmaceutical company focused on discovering , developing and commercializing novel small - molecule therapeutics derived from its boron chemistry platform . anacor has discovered seven compounds that are currently in development . its two lead product candidates are topically administered dermatologic compounds — tavaborole , a topical antifungal for the treatment of onychomycosis , and an2728 , a topical anti - inflammatory pde - 4 inhibitor for the treatment of atopic dermatitis and psoriasis . in addition to its two lead programs , anacor has discovered three other wholly - owned clinical product candidates — an2718 and an2898 , which are backup compounds to tavaborole and an2728 , respectively , and an3365 an antibiotic for the treatment of infections caused by gram - negative bacteria . we have discovered two other compounds that we have out - licensed for further development — one compound for the treatment of an animal health indication that is licensed to eli lilly and company and an5568 , also referred to as scyx - 7158 , for human african trypanosomiasis ( hat , or sleeping sickness ) , which is licensed to drugs for neglected diseases initiative , or dndi . we also have a pipeline of other internally discovered topical and systemic boron - based compounds in development . for more information , visit urltoken .
both an2728 and an2898 have demonstrated efficacy in human clinical trials of psoriasis ,
said david perry , chief executive officer of anacor pharmaceuticals .
pre - clinical studies suggest that they may also be effective in treating atopic dermatitis . this trial is intended to understand the potential of each compound to treat the disease , and , if effective , determine which compound to progress further in development .
a further description of risks and uncertainties relating to pfizer and anacor can be found in their respective annual reports on form 10 - k for the fiscal year ended december 31 , 2015 and in their subsequent quarterly reports on form 10 - q and current reports on form 8 - k , all of which are filed with the u . s . securities and exchange commission ( the “sec” ) and available at urltoken .
we are pleased to announce the fda approval of kerydin , which provides an important new topical treatment option for the millions of people in the united states who are infected with onychomycosis of the toenails ,
said paul berns , chief executive officer of anacor pharmaceuticals .
we expect to launch kerydin in the u . s . , either alone or with a partner , as early as the end of this quarter .
taking this step by step , pfizer really is getting two assets : kerydin and cirsaborole . anacor does have other topical anti - inflammatory products in development , but they ' re all in the discovery or preclinical stages of development . aside from these two therapies , the only other drug in clinical studies is an3365 for infections caused by gram - negative bacteria , and it ' s far too early to tell if this clinical therapeutic is effective .
anacor pharmaceuticals ( nasdaq : anac ) announced today preliminary results from its phase 2b trial of an2728 for the treatment of mild - to - moderate plaque - type psoriasis . the trial enrolled 68 subjects randomized in a 2 : 1 ratio , an2728 to vehicle . subjects treated with an2728 showed improvement over vehicle at each of the recorded timepoints during the 12 - week study period with peak efficacy of 26 % occurring after six weeks of treatment with an2728 .
prior to anacor’s experimentation with boron , researchers had limited understanding of the physical properties of the chemical element , despite its occurrence in many natural substances , such as fruits , vegetables , milk , and coffee . in their early years , the company explored the potential uses of boron in drug development and found that their boron platform had potential applications in the treatment of multiple diseases including bacterial , fungal , viral , and parasitic infections as well as inflammatory diseases .
anacor conducted two separate phase 3 studies of tavaborole on patients with distal subungual onychomycosis affecting 20 to 60 percent of the target great toenail . approximately 600 patients aged 18 years and older with no upper age limit ( the oldest subject was 88 years old ) were enrolled in each study and randomized two - to - one to receive either tavaborole or the vehicle control . patients were instructed to apply tavaborole solution or the vehicle to the toenail once daily for 48 weeks .
as announced earlier this year , tavaborole achieved statistically significant and clinically meaningful results on all primary and secondary endpoints in two phase 3 pivotal studies without concomitant debridement . anacor is seeking approval for tavaborole from the food and drug administration ( fda ) and will file a new drug application imminently . currently , there is only one fda - approved topical treatment for onychomycosis , a fungal infection of the nail and nail bed , which affects approximately 35 million people in the united states .
it was while working under the defense contract that anacor hired naeja to assist the two chemists on its staff . at the time , naeja was a three - year - old contract research firm run by ronald micetich and his son christopher . based in edmonton , alberta , the firm is staffed by chemists and biologists from a variety of nations who have found canada welcoming to highly educated immigrants . about three - quarters of its staff are chemists , and almost all have ph . d . s .
we are pleased with the results of this study and we are on track with our plans to file an nda in the middle of this year ,
said david perry , chief executive officer of anacor .
in both phase 3 trials , tavaborole demonstrated better efficacy than ciclopirox lacquer , the only approved topical treatment for onychomycosis . importantly , ciclopirox lacquer requires concomitant nail debridement . if approved , tavaborole could offer patients and prescribers a safe , effective and convenient topical treatment option for onychomycosis .
“these data confirm the safety of an2728 and the potential for it to be used on areas of the body that are susceptible to side effects from steroids and tend to be sensitive to irritation from vitamin d analogs , ” said david perry , ceo of anacor pharmaceuticals . “all of the clinical studies we have done to date on an2728 in psoriasis and atopic dermatitis support that it could be a potentially safe and effective topical treatment for patients who suffer from mild - to - moderate psoriasis or atopic dermatitis . ”
the payoff for all of the work was a licensing deal with gsk . last july , the british firm paid anacor $ 15 million and exercised its option to take over development of an3365 . david j . payne , vice president of gsk’s antibacterial drug discovery unit , lauded the compound , now renamed gsk2251052 , as having “the potential to be the first new - class antibacterial to treat serious hospital gram - negative infections in 30 years . ” gsk chemists have since developed a stereospecific synthesis for commercial - scale production .
according to anacor’s researchers , boron has two unique qualities that give it advantages in the drug discovery process . “first , boron has a unique geometry that allows compounds made from it to have two distinct shapes , giving boron - based drugs the ability to interact with biological targets in novel ways and to address targets not amenable to intervention by traditional carbon - based compounds . and second , boron ' s enhanced reactivity as compared to carbon allows the molecules to hit targets that are difficult to destroy with carbon chemistry . ”
palo alto , calif . - - ( business wire ) - - anacor pharmaceuticals , inc . ( nasdaq : anac ) today announced that the u . s . food and drug administration ( fda ) has approved the new drug application for kerydin™ ( tavaborole ) topical solution , 5 % , the first oxaborole antifungal approved for the topical treatment of onychomycosis of the toenails . onychomycosis is a fungal infection of the nail and nail bed that affects approximately 35 million people in the united states , according to podiatry today .
anacor pharmaceuticals ( nasdaq : anac ) announced today that its abstract “pivotal phase 3 safety and efficacy results of tavaborole ( formerly an2690 ) , a novel boron - based molecule for the topical treatment of toenail onychomycosis” was accepted for oral presentation at the 2013 apma annual scientific meeting ( the national ) to be held in las vegas , nevada . max weisfeld , dpm , will present the data from tavaborole ' s phase 3 studies on monday , july 22 , 2013 during the evidence - based medicine and oral abstracts session .
“we believe the acquisition of anacor represents an attractive opportunity to address a significant unmet medical need for a large patient population with mild - to - moderate atopic dermatitis , which currently has few safe topical treatments available , ” said albert bourla , group president of pfizer’s global innovative pharma and global vaccines , oncology and consumer healthcare businesses . “crisaborole is a differentiated asset with compelling clinical data that , if approved , has the potential to be an important first - line treatment option for these patients and the physicians who treat them . ”
in both of its phase 3 pivotal studies , crisaborole achieved statistically significant results on all primary and secondary endpoints and in march 2016 , the fda accepted for review anacor’s new drug application seeking approval of crisaborole for the potential treatment of mild - to - moderate atopic dermatitis in children and adults . the prescription drug user fee act ( pdufa ) goal date for the completion of the fda’s review is january 7 , 2017 . if approved , pfizer believes peak year sales for crisaborole have the potential to reach or exceed $ 2 . 0 billion .
this early - stage trial demonstrated definitive anti - inflammatory activity in humans . we are encouraged that the compound decreases tnf - alpha , a cytokine known to be important in psoriasis , by the inhibition of pde4 , a well - validated anti - inflammatory target ,
said karl beutner , anacor ' s chief medical officer .
a topical compound that effectively targets tnf - alpha would have great promise , and we intend to initiate further clinical trials to characterize the clinical utility of this drug in psoriasis and other inflammatory skin diseases .
“we are encouraged by this preliminary data demonstrating the safety and efficacy of both an2728 and an2898 in atopic dermatitis and believe it supports further development of one or both of these compounds in this indication , ” said david perry , anacor’s chief executive officer . “due to the large number of children who suffer from atopic dermatitis , safety is a critical consideration in the treatment of this disease . given the promising profiles of an2728 and an2898 , we believe that both compounds have the potential to become safe and effective alternatives to existing treatments for atopic dermatitis . ”
anacor , a privately held , clinical - stage pharmaceutical company , is developing novel product candidates for inflammatory , fungal and bacterial diseases based on its proprietary , small - molecule , boron - based chemistry . the company ' s lead product is an2690 , which is in phase 2 trials for onychomycosis , a fungal infection of the nail and nailbed . ancor has entered into an exclusive , worldwide agreement with schering - plough corporation to develop and commercialize the drug . the company is also conducting clinical trials with two anti - inflammatory product candidates , an2728 and an0128
) - - anacor pharmaceuticals ( nasdaq : anac ) today announced positive preliminary results from the second of two phase 3 trials of tavaborole ( known as study 302 ) . tavaborole is a topical anti - fungal for the treatment of onychomycosis , a fungal infection of the nail and nail bed that affects approximately 35 million people in the united states . results from the first phase 3 trial ( known as study 301 ) were announced on january 29 , 2013 . in both studies , tavaborole achieved statistically significant and clinically meaningful results on all primary and secondary endpoints .