Abstract: We found two randomised clinical trials including 154 adult participants, aged between 18 years and 65 years, diagnosed with hepatosplenic schistosomiasis. One of the trials randomised participants to proximal splenorenal shunt versus distal splenorenal shunt versus oesophagogastric devascularisation with splenectomy, and the other randomised participants to distal splenorenal shunt versus oesophagogastric devascularisation with splenectomy. In both trials the diagnosis of hepatosplenic schistosomiasis was made based on clinical and biochemical assessments. The trials were conducted in Brazil and Egypt. Both trials were at high risk of bias. We are uncertain as to whether surgical portosystemic shunts improved all-cause mortality compared with oesophagogastric devascularisation with splenectomy due to imprecision in the trials (risk ratio (RR) 2.35, 95% confidence interval (CI) 0.55 to 9.92; participants = 154; studies = 2). We are uncertain whether serious adverse events differed between surgical portosystemic shunts and oesophagogastric devascularisation with splenectomy (RR 2.26, 95% CI 0.44 to 11.70; participants = 154; studies = 2). None of the trials reported on health-related quality of life. We are uncertain whether variceal rebleeding differed between surgical portosystemic shunts and oesophagogastric devascularisation with splenectomy (RR 0.39, 95% CI 0.13 to 1.23; participants = 154; studies = 2). We found evidence suggesting an increase in encephalopathy in the shunts group versus the devascularisation with splenectomy group (RR 7.51, 95% CI 1.45 to 38.89; participants = 154; studies = 2). We are uncertain whether ascites and re-interventions differed between surgical portosystemic shunts and oesophagogastric devascularisation with splenectomy. We computed Trial Sequential Analysis for all outcomes, but the trial sequential monitoring boundaries could not be drawn because of insufficient sample size and events. We downgraded the overall certainty of the body of evidence for all outcomes to very low due to risk of bias and imprecision. Given the very low certainty of the available body of evidence and the low number of clinical trials, we could not determine an overall benefit or harm of surgical portosystemic shunts compared with oesophagogastric devascularisation with splenectomy. Future randomised clinical trials should be designed with sufficient statistical power to assess the benefits and harms of surgical portosystemic shunts versus oesophagogastric devascularisations with or without splenectomy and with or without oesophageal transection.

Plain-language summary: We found two randomised clinical trials (types of studies in which participants are assigned to treatment group using a random method) involving a total of 154 adult participants who received either a non-selective shunt surgery, a selective shunt surgery, or devascularisation surgery. However, the design of both trials was of insufficient quality, as the numbers of trial participants were small, and some participant information was lacking. One of the trials was funded by an institutional grant, and how funding was obtained for the other trial was not clear. We assessed both trials as at high risk of bias. There were no significant differences in the number of participants who had repeat bleeding, adverse effects of treatment, or deaths between the shunt surgery and the devascularisation group, but participants who had devascularisation were less likely to suffer encephalopathy (disease of the brain due to damage from toxins produced by the liver). Neither of the trials addressed quality of life after treatment. Given the very low certainty of the evidence due to the way the clinical trials were performed, limited trial data and trial participants, we were unable to determine whether one treatment is better than the other. We suggest that future trials include a sufficient number of randomised participants to be able to obtain meaningful results on patient-relevant outcomes and allow objective comparison of these two surgery types.